Search of human proteins with 4507043

Search of human proteins with 4507043

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
         (630 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507043 solute carrier family 6 member 4 [Homo sapiens]           1300   0.0  
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            622   e-178
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   612   e-175
gi|171184408 solute carrier family 6 (neurotransmitter transport...   513   e-145
gi|171184406 solute carrier family 6 (neurotransmitter transport...   513   e-145
gi|171184404 solute carrier family 6 (neurotransmitter transport...   513   e-145
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   509   e-144
gi|188528618 solute carrier family 6 (neurotransmitter transport...   509   e-144
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   503   e-142
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   501   e-142
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   500   e-141
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         493   e-139
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   488   e-138
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   488   e-138
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   487   e-137
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   483   e-136
gi|197276623 solute carrier family 6 (neurotransmitter transport...   482   e-136
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   482   e-136
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   454   e-127
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   395   e-110
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         366   e-101
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        358   8e-99
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   358   1e-98
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   338   9e-93
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   308   1e-83
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         303   3e-82
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   272   6e-73
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         226   5e-59
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   180   3e-45
gi|197276625 solute carrier family 6 (neurotransmitter transport...   179   5e-45

>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score = 1300 bits (3363), Expect = 0.0
 Identities = 630/630 (100%), Positives = 630/630 (100%)

Query: 1   METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR 60
           METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
Sbjct: 1   METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR 60

Query: 61  HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP 120
           HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
Sbjct: 61  HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP 120

Query: 121 YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM 180
           YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
Sbjct: 121 YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM 180

Query: 181 AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH 240
           AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
Sbjct: 181 AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH 240

Query: 241 RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA 300
           RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
Sbjct: 241 RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA 300

Query: 301 TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD 360
           TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
Sbjct: 301 TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD 360

Query: 361 ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS 420
           ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
Sbjct: 361 ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS 420

Query: 421 TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT 480
           TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
Sbjct: 421 TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT 480

Query: 481 LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC 540
           LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
Sbjct: 481 LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC 540

Query: 541 WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT 600
           WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
Sbjct: 541 WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT 600

Query: 601 PGTFKERIIKSITPETPTEIPCGDIRLNAV 630
           PGTFKERIIKSITPETPTEIPCGDIRLNAV
Sbjct: 601 PGTFKERIIKSITPETPTEIPCGDIRLNAV 630


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  622 bits (1604), Expect = e-178
 Identities = 289/543 (53%), Positives = 391/543 (72%), Gaps = 9/543 (1%)

Query: 79  RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138
           RETWGKK+DFLLSV+G+AVDL NVWRFPY+CY+NGGGAFL+PYT+  I  G+PLFYMELA
Sbjct: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115

Query: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198
           LGQY+R G  ++W KICP FKG+GYA+ +IA Y+  YYN I+AW+LYYL SSFT  LPWT
Sbjct: 116 LGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174

Query: 199 SCKNSWNTGNCTN------YFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS 252
            C ++WN+ NCT+          ++  ++ +  +PA EFY R VL +H S G+ D+G   
Sbjct: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQ 234

Query: 253 WQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFY 312
           WQL LC+M++  V+YFS+WKGVKTSGKVVW+TAT PY +L VLLV G TLPGA  G+  Y
Sbjct: 235 WQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAY 294

Query: 313 LKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTS 372
           L  ++ +L E  VWIDAA QIFFSLG GFGVL+AFASYNKF+NNCY+DAL+TS +NC+TS
Sbjct: 295 LHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITS 354

Query: 373 FVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLI 432
           FVSGF IF++LGYMA     ++ +VA + G  L+FI Y EAI+ +  STF+A++FF+ML+
Sbjct: 355 FVSGFAIFSILGYMAHEHKVNIEDVATE-GAGLVFILYPEAISTLSGSTFWAVVFFVMLL 413

Query: 433 TLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492
            LGLDS+  G+E VIT + D+F  V  + R+ F   V  + F  +L  +T GG YV+ LL
Sbjct: 414 ALGLDSSMGGMEAVITGLADDF-QVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLL 472

Query: 493 EEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFI 552
           + +A G ++L   L+EA+ VSWFYG+ +F  D+++M+GF PG +WR+CW  +SP FLLF+
Sbjct: 473 DTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFV 532

Query: 553 ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSI 612
           +   +++   L    Y +P W+  +G+ I  SS + +P Y+ Y+ + T G+  ER+   I
Sbjct: 533 VVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGI 592

Query: 613 TPE 615
           TPE
Sbjct: 593 TPE 595


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  612 bits (1577), Expect = e-175
 Identities = 287/577 (49%), Positives = 404/577 (70%), Gaps = 13/577 (2%)

Query: 60  RHSIPATTTTLV----AELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGG 115
           ++ +  T++TL     + +   +RETWGKK+DFLLSVIG+AVDL NVWRFPY+CY+NGGG
Sbjct: 37  QNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGG 96

Query: 116 AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASY 175
           AFL+PY +  +  G+PLFYMELALGQ++R G   +W KICPI KG+G+ + +I+ Y+  +
Sbjct: 97  AFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPILKGVGFTVILISLYVGFF 155

Query: 176 YNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWT-----LHSTSPAEE 230
           YN I+AWAL+YL SSFT +LPW  C NSWN+ NC++    D+   +        T+PA E
Sbjct: 156 YNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAE 215

Query: 231 FYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYI 290
           ++ R VL +H+S G+ DLG   WQL  C++L+  ++YFS+WKGVKTSGKVVW+TAT PY+
Sbjct: 216 YFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYV 275

Query: 291 ILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASY 350
           +L+ LL+RG TLPGA  G+  YL  ++ +L E  VWIDAA Q+ FSLG GFGVL+AF+SY
Sbjct: 276 VLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSY 335

Query: 351 NKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITY 410
           NKF NNCY+DA+VT+ +N +TSF SGFV+F+ LGYMA+  +  + +VAKD GP L+FI Y
Sbjct: 336 NKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKD-GPGLIFIIY 394

Query: 411 AEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVV 470
            EAIA +P S+ +A++FF+ML+TLG+DS   G+E VIT ++DEF  +  + RE F L +V
Sbjct: 395 PEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF-QLLHRHRELFTLFIV 453

Query: 471 ITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLG 530
           +  F  SL  +T GG YV  LL+ +A G ++L   LIEA+ V+WFYG+ QF  D+++M G
Sbjct: 454 LATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTG 513

Query: 531 FSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIP 590
             P  +WR+CW  +SP FLLF++   +++        Y +P W+  LG+ I TSS   +P
Sbjct: 514 QRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVP 573

Query: 591 TYIAYRLIITPGTFKERIIKSITPETPTE-IPCGDIR 626
            Y AY+    PG+F+E++  +I PE   E +  G++R
Sbjct: 574 IYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVR 610


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  513 bits (1321), Expect = e-145
 Identities = 249/561 (44%), Positives = 371/561 (66%), Gaps = 20/561 (3%)

Query: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
           +R  W  K++F+LSV G  + LGNVWRFPY+CY+NGGGAF +PY I     GIP+F++E+
Sbjct: 35  DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEV 94

Query: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197
           ALGQY   G ++ WRKICP+F+GIG A  +I  Y+  YY  I+AWAL+YL SSFT +LPW
Sbjct: 95  ALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPW 154

Query: 198 TSCKNSWNTGNCTNYFSEDN---ITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQ 254
           T+C N WNT +CT++ +      +T   + TSP  EF+ R VL I  + G+ DLG + W+
Sbjct: 155 TTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGI--TSGIHDLGSLRWE 212

Query: 255 LALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLK 314
           LALC++L + + YF IWKGVK++GKVV+ TATFPY++L +LL+RG TLPGA++G+++YLK
Sbjct: 213 LALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLK 272

Query: 315 PNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFV 374
           P+  +L +  VW+DA  QIFFS     G L A  SYNK++NNCY+D +    +N  TSFV
Sbjct: 273 PDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFV 332

Query: 375 SGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITL 434
           +GFV+F++LG+M++ +   +SEVA ++GP L FI + +A+  MP S  ++ +FF+MLI L
Sbjct: 333 AGFVVFSILGFMSQEQGVPISEVA-ESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFL 391

Query: 435 GLDSTFAGLEGVITAVLDEFPHVWAK--RRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492
           GLDS F  +E ++TA +D FP    K  RRE  +L + + C+   L  +T GG Y+ +L 
Sbjct: 392 GLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLF 451

Query: 493 EEYA-TGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLF 551
           + YA +G  +L ++L E V +SW YG  +F  ++++M+G+ P    +I W+ ++P   L 
Sbjct: 452 DYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCL- 510

Query: 552 IICSFLMSPPQLRLFQYN----YPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607
              +FL S  +    +YN    YP W   +G+ +  SS +C+P ++   L+ T G F++R
Sbjct: 511 --ATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKR 568

Query: 608 IIKSITPET----PTEIPCGD 624
           + + ITP++    P + PC D
Sbjct: 569 LRQLITPDSSLPQPKQHPCLD 589


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  513 bits (1321), Expect = e-145
 Identities = 249/561 (44%), Positives = 371/561 (66%), Gaps = 20/561 (3%)

Query: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
           +R  W  K++F+LSV G  + LGNVWRFPY+CY+NGGGAF +PY I     GIP+F++E+
Sbjct: 35  DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEV 94

Query: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197
           ALGQY   G ++ WRKICP+F+GIG A  +I  Y+  YY  I+AWAL+YL SSFT +LPW
Sbjct: 95  ALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPW 154

Query: 198 TSCKNSWNTGNCTNYFSEDN---ITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQ 254
           T+C N WNT +CT++ +      +T   + TSP  EF+ R VL I  + G+ DLG + W+
Sbjct: 155 TTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGI--TSGIHDLGSLRWE 212

Query: 255 LALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLK 314
           LALC++L + + YF IWKGVK++GKVV+ TATFPY++L +LL+RG TLPGA++G+++YLK
Sbjct: 213 LALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLK 272

Query: 315 PNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFV 374
           P+  +L +  VW+DA  QIFFS     G L A  SYNK++NNCY+D +    +N  TSFV
Sbjct: 273 PDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFV 332

Query: 375 SGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITL 434
           +GFV+F++LG+M++ +   +SEVA ++GP L FI + +A+  MP S  ++ +FF+MLI L
Sbjct: 333 AGFVVFSILGFMSQEQGVPISEVA-ESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFL 391

Query: 435 GLDSTFAGLEGVITAVLDEFPHVWAK--RRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492
           GLDS F  +E ++TA +D FP    K  RRE  +L + + C+   L  +T GG Y+ +L 
Sbjct: 392 GLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLF 451

Query: 493 EEYA-TGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLF 551
           + YA +G  +L ++L E V +SW YG  +F  ++++M+G+ P    +I W+ ++P   L 
Sbjct: 452 DYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCL- 510

Query: 552 IICSFLMSPPQLRLFQYN----YPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607
              +FL S  +    +YN    YP W   +G+ +  SS +C+P ++   L+ T G F++R
Sbjct: 511 --ATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKR 568

Query: 608 IIKSITPET----PTEIPCGD 624
           + + ITP++    P + PC D
Sbjct: 569 LRQLITPDSSLPQPKQHPCLD 589


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  513 bits (1321), Expect = e-145
 Identities = 249/561 (44%), Positives = 371/561 (66%), Gaps = 20/561 (3%)

Query: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
           +R  W  K++F+LSV G  + LGNVWRFPY+CY+NGGGAF +PY I     GIP+F++E+
Sbjct: 35  DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEV 94

Query: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197
           ALGQY   G ++ WRKICP+F+GIG A  +I  Y+  YY  I+AWAL+YL SSFT +LPW
Sbjct: 95  ALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPW 154

Query: 198 TSCKNSWNTGNCTNYFSEDN---ITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQ 254
           T+C N WNT +CT++ +      +T   + TSP  EF+ R VL I  + G+ DLG + W+
Sbjct: 155 TTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGI--TSGIHDLGSLRWE 212

Query: 255 LALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLK 314
           LALC++L + + YF IWKGVK++GKVV+ TATFPY++L +LL+RG TLPGA++G+++YLK
Sbjct: 213 LALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLK 272

Query: 315 PNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFV 374
           P+  +L +  VW+DA  QIFFS     G L A  SYNK++NNCY+D +    +N  TSFV
Sbjct: 273 PDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFV 332

Query: 375 SGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITL 434
           +GFV+F++LG+M++ +   +SEVA ++GP L FI + +A+  MP S  ++ +FF+MLI L
Sbjct: 333 AGFVVFSILGFMSQEQGVPISEVA-ESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFL 391

Query: 435 GLDSTFAGLEGVITAVLDEFPHVWAK--RRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492
           GLDS F  +E ++TA +D FP    K  RRE  +L + + C+   L  +T GG Y+ +L 
Sbjct: 392 GLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLF 451

Query: 493 EEYA-TGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLF 551
           + YA +G  +L ++L E V +SW YG  +F  ++++M+G+ P    +I W+ ++P   L 
Sbjct: 452 DYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCL- 510

Query: 552 IICSFLMSPPQLRLFQYN----YPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607
              +FL S  +    +YN    YP W   +G+ +  SS +C+P ++   L+ T G F++R
Sbjct: 511 --ATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKR 568

Query: 608 IIKSITPET----PTEIPCGD 624
           + + ITP++    P + PC D
Sbjct: 569 LRQLITPDSSLPQPKQHPCLD 589


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  509 bits (1310), Expect = e-144
 Identities = 254/574 (44%), Positives = 367/574 (63%), Gaps = 13/574 (2%)

Query: 52  SPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQ 111
           +PG G  +  + PA    +  +    ER  W  KV+F+LSV G  + LGNVWRFPY+CY+
Sbjct: 23  APGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYK 82

Query: 112 NGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFY 171
           NGGGAFL+PY +  I  GIP+F++E ALGQ+   G I+ WRK+CP+F+GIGYA  +I  +
Sbjct: 83  NGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAH 142

Query: 172 IASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLH-----STS 226
           +  YY  I+AWA++YL + FT +LPW +C + WNT NC   F + N++   H     +TS
Sbjct: 143 LNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVE-FQKLNVSNYSHVSLQNATS 201

Query: 227 PAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTAT 286
           P  EF+   VL I  S G++ +G + W+LALC++  +T+ YF IWKG K++GKVV+VTAT
Sbjct: 202 PVMEFWEHRVLAI--SDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTAT 259

Query: 287 FPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLA 346
           FPYI+L +LL+RG TLPGA  G+ FYL P+  +L +  VW+DA  QIFFS     G L A
Sbjct: 260 FPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTA 319

Query: 347 FASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLL 406
             SYN +NNNCY+D ++   +N  TSFV+GF IF+VLG+MA  +   ++EVA ++GP L 
Sbjct: 320 LGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVA-ESGPGLA 378

Query: 407 FITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAK--RRER 464
           FI Y +A+  MP S  +A +FF+MLI LGLDS F  +E ++TAV+D +P V+ +  RRE 
Sbjct: 379 FIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRREL 438

Query: 465 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEY-ATGPAVLTVALIEAVAVSWFYGITQFCR 523
            +LA+ +  +F  LV LT GG Y+ +L + Y A+G  +L VA+ E + + W YG  +F  
Sbjct: 439 LILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYD 498

Query: 524 DVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQ-YNYPYWSIILGYCIG 582
           ++++M+G+ P    + CW+ ++P     I   FL+    L+    Y YP W   +G+ + 
Sbjct: 499 NIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMA 558

Query: 583 TSSFICIPTYIAYRLIITPGTFKERIIKSITPET 616
            SS +CIP +I   +  T GT  E++ K  TP T
Sbjct: 559 LSSMLCIPLWICITVWKTEGTLPEKLQKLTTPST 592


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  509 bits (1310), Expect = e-144
 Identities = 252/585 (43%), Positives = 375/585 (64%), Gaps = 17/585 (2%)

Query: 33  TPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSV 92
           T G KV  GQIS   S  P     +D   ++        A+L   +R+TW  + DFL+S 
Sbjct: 3   TNGSKVADGQISTEVSEAP---VANDKPKTLVVKVQKKAADLP--DRDTWKGRFDFLMSC 57

Query: 93  IGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWR 152
           +GYA+ LGNVWRFPY+C +NGGGAFL+PY +  IF G+PLF +E +LGQY   G + +W 
Sbjct: 58  VGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVW- 116

Query: 153 KICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNY 212
           K+ P+FKG+G A  +++F++  YY  I++WA+YYL +SFT  LPW  C N WNT  C + 
Sbjct: 117 KLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSN 176

Query: 213 FSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWK 272
           +S  N T   + TS   EF+ R++ Q+  + GL   G I W LA+ + + + ++YF IWK
Sbjct: 177 YSMVNTT---NMTSAVVEFWERNMHQM--TDGLDKPGQIRWPLAITLAIAWILVYFCIWK 231

Query: 273 GVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQ 332
           GV  +GKVV+ +AT+PYI+L +L  RG TLPGA  G+LFY+ PN++KL ++ VW+DAA Q
Sbjct: 232 GVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQ 291

Query: 333 IFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNE 392
           IFFS G G G L+A  SYN F+NN Y+D+++   +N  TS  +GFVIF+++G+MA +   
Sbjct: 292 IFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKR 351

Query: 393 DVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLD 452
            +++VA  +GP L F+ Y EA+  +P S  +AI+FF ML+ LG+DS F  +EG ITA++D
Sbjct: 352 SIADVAA-SGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVD 410

Query: 453 EFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEY-ATGPAVLTVALIEAVA 511
           E+P +   RRE F+ AV I  +   L  +T GG YV KL + Y A+G ++L +   E V+
Sbjct: 411 EYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVS 470

Query: 512 VSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFL--LFIICSFLMSPPQLRLFQYN 569
           +SWFYG+ +F  +++EM+G  P  +W++CW   +P+ +  +FI  +  M+P  L +  Y 
Sbjct: 471 ISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTP--LTMGNYV 528

Query: 570 YPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITP 614
           +P W   +G+ +  SS + IP Y+AY  +   G+ K+RI   + P
Sbjct: 529 FPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQP 573


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  503 bits (1296), Expect = e-142
 Identities = 250/554 (45%), Positives = 357/554 (64%), Gaps = 11/554 (1%)

Query: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
           ER  W  K++F+LSV G  + LGNVWRFPY+CY+NGGGAF +PY +     GIP+F +E 
Sbjct: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90

Query: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197
           ALGQY   G ++ WRKICPIF+GIGYA  +I   +  YY  ++AWAL+YL SSFT  LPW
Sbjct: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150

Query: 198 TSCKNSWNTGNCTNYFSEDNIT--WTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255
             C + WNT +C  +   +      + ++TSP  EF+ R VL+I  S G+Q LG + W+L
Sbjct: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKI--SDGIQHLGALRWEL 208

Query: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKP 315
           ALC++L + + YF IWKGVK++GKVV+ TATFPY++L VLL+RG TLPGA +G+ FYL P
Sbjct: 209 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYP 268

Query: 316 NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVS 375
           N  +L +  VW+DA  QIFFS     G L A  SYNK++NNCY+D +    +N  TSFV+
Sbjct: 269 NLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVA 328

Query: 376 GFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLG 435
           GF IF++LG+M++ +   +SEVA ++GP L FI Y  A+  +P S  +A  FF M++ LG
Sbjct: 329 GFAIFSILGFMSQEQGVPISEVA-ESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLG 387

Query: 436 LDSTFAGLEGVITAVLDEFPHVWAK--RRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE 493
           LDS F  +E ++TA++D +PHV+ K  RRE  +L V +  F   L+ LT GG YV +L +
Sbjct: 388 LDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFD 447

Query: 494 EY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISP-LFLLF 551
            Y A+G  +L VA+ E++ V+W YG  +F  ++++M+G+ P    + CW+ ++P +    
Sbjct: 448 YYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTAT 507

Query: 552 IICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKS 611
            + S +   P     +Y YP+W   LG+ +  SS +CIP +  YRL    G F+ERI + 
Sbjct: 508 FLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQL 567

Query: 612 ITP--ETPTEIPCG 623
           + P  + P   P G
Sbjct: 568 MCPAEDLPQRNPAG 581


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  501 bits (1291), Expect = e-142
 Identities = 249/602 (41%), Positives = 362/602 (60%), Gaps = 49/602 (8%)

Query: 55  AGDDTRHSIPATTTTLVA-ELHQGE----RETWGKKVDFLLSVIGYAVDLGNVWRFPYIC 109
           A D     +P +  T+   E  QG+    R  W  K+DF+LS++GYAV LGNVWRFPY+ 
Sbjct: 162 ATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLA 221

Query: 110 YQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIA 169
           +QNGGGAFL+PY +M    G+P+F++E++LGQ+   G +S+W+ I P  +G G A+ II+
Sbjct: 222 FQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIIS 280

Query: 170 FYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNC-------------------- 209
             IA YYN I+ + L+YL +SF   LPW SC N WNT  C                    
Sbjct: 281 VLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQ 340

Query: 210 ----------------TNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISW 253
                            N+ S+ N T+     S +EE++   VL+I  S G++  G I W
Sbjct: 341 IKNSTFCMTAYPNVTMVNFTSQANKTFV----SGSEEYFKYFVLKI--SAGIEYPGEIRW 394

Query: 254 QLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYL 313
            LALC+ L + ++Y S+ KG+KTSGKVV+ TATFPY++L +LL+RG TLPGA  G+ +++
Sbjct: 395 PLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFI 454

Query: 314 KPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSF 373
            P W+KL +  VW DAA QIFFSL   +G L+  +SYNKF+NNCY+D L+ +  N  TS 
Sbjct: 455 TPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSI 514

Query: 374 VSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLIT 433
            +GFVIF+V+G+MA  R  ++  VA D GP + F+ Y EA+  +P S F+AIIFFLML+T
Sbjct: 515 FAGFVIFSVIGFMANERKVNIENVA-DQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLT 573

Query: 434 LGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE 493
           LGLD+ FA +E ++T++ DEFP      +  F L   I  F      +T GG Y+ +L++
Sbjct: 574 LGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVD 633

Query: 494 EYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFII 553
            YA   A++ +A+ E V +S+ YG+ +FC D++ M+GF P  FW++CW  ++P  L FI+
Sbjct: 634 TYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFIL 693

Query: 554 CSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSIT 613
           C        +    Y YP WS++LG+ +   S I IP     ++ + PG F ER+    +
Sbjct: 694 CFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCS 753

Query: 614 PE 615
           P+
Sbjct: 754 PQ 755


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  500 bits (1288), Expect = e-141
 Identities = 253/599 (42%), Positives = 369/599 (61%), Gaps = 29/599 (4%)

Query: 23  ENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETW 82
           ENG+        GD+ +   I+ G    P+ G G       P    T    L    RETW
Sbjct: 7   ENGIYS----VSGDEKKGPLIAPGPDGAPAKGDG-------PVGLGTPGGRLAVPPRETW 55

Query: 83  GKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142
            +++DF++S +G+AV LGNVWRFPY+CY+NGGG FL+PY ++A+ GGIP+F++E++LGQ+
Sbjct: 56  TRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQF 115

Query: 143 HRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKN 202
            + G I++W  ICP+FKG+GYA  +I FY  +YY  ++AW  YYL+ SFT  LPW +C +
Sbjct: 116 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 174

Query: 203 SWNTGNCTNYFSED--------NITWT--LHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS 252
           +WNT +C   F  +        N+T        SP  EF+   VL++  S GL+  G ++
Sbjct: 175 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALN 232

Query: 253 WQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFY 312
           W++ LC++  + ++YF +WKGVK++GK+V+ TATFPY++L VLLVRG  LPGA  G+++Y
Sbjct: 233 WEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYY 292

Query: 313 LKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTS 372
           LKP+W KL    VWIDA  QIFFS   G G L A  SYN+FNNNCY+DA++ +++N  TS
Sbjct: 293 LKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTS 352

Query: 373 FVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLI 432
           F +GFV+F++LG+MA  +   +S+VA ++GP L FI Y  A+  MP +  +A +FF ML+
Sbjct: 353 FFAGFVVFSILGFMAAEQGVHISKVA-ESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 411

Query: 433 TLGLDSTFAGLEGVITAVLDEFP--HVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVK 490
            LGLDS F G+EG IT +LD  P  + +  +RE  V      CF   L  +T GG YV +
Sbjct: 412 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 471

Query: 491 LLEEY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFL 549
           L + Y A+G  +L  A  E V V+W YG  +F  D+  M+G+ P  + + CW   +PL  
Sbjct: 472 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 531

Query: 550 LFI-ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607
           + I I + +   P +    Y YP+W   +G+    SS +C+P ++   L+   GT  ER
Sbjct: 532 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 590


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  493 bits (1269), Expect = e-139
 Identities = 253/569 (44%), Positives = 360/569 (63%), Gaps = 23/569 (4%)

Query: 64  PATTTTLVAELHQGE----------RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNG 113
           P T   L+    QG+          R  W  K+DFLLS IGY V LGNVWRFPY  Y NG
Sbjct: 12  PVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNG 71

Query: 114 GGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIA 173
           GGAFL+PY +M    GIPLF++EL+LGQ+   G +++W KI P+FKG G A+ +I   +A
Sbjct: 72  GGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVA 130

Query: 174 SYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNY-FSED-------NITWTLHST 225
            YYN I+A+ L+YL +S T  LPW  C N WNT  C  +  S+D       N+T T+   
Sbjct: 131 IYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTV--- 187

Query: 226 SPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTA 285
           SP+EE+++R+VL I  S+G+   G I W L LC++L + +++  I KGVK+SGKVV+ TA
Sbjct: 188 SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTA 247

Query: 286 TFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLL 345
           TFPY+IL +LLVRG TLPGAW+G+ FYL P +  LL + VWI+AA QIF+SLG GFG LL
Sbjct: 248 TFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLL 307

Query: 346 AFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSL 405
            FASYN F+ N Y+D  + ++ N +TS ++GF IF+VLGYM++     V +VAK AGP L
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAK-AGPGL 366

Query: 406 LFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERF 465
            F+ Y +A+  +P S F++ +FF ML+TLGLDS FA LE ++TAV DEFP+    ++  F
Sbjct: 367 AFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVF 426

Query: 466 VLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDV 525
              + +  +   L+  T GG Y + LL++Y+    ++ V +   +AV+  YGI +FCRD+
Sbjct: 427 SGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDI 486

Query: 526 KEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSS 585
             MLGF PG ++R CW+ +SP  LL ++   ++         Y +P W+ +LG  +G  S
Sbjct: 487 HMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLS 546

Query: 586 FICIPTYIAYRLIITPGTFKERIIKSITP 614
            + IP  +   ++   G+  ER+ ++  P
Sbjct: 547 CLMIPAGMLVAVLREEGSLWERLQQASRP 575


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  488 bits (1255), Expect = e-138
 Identities = 239/580 (41%), Positives = 361/580 (62%), Gaps = 26/580 (4%)

Query: 54  GAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNG 113
           GA      ++P+  T     L +G    WG +++F+L+ +GYAV LGNVWRFPY+CY+NG
Sbjct: 5   GAKGMLNGAVPSEATKRDQNLKRGN---WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNG 61

Query: 114 GGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIA 173
           GGAF+ PY IM IF GIPLF+MEL+ GQ+   GC+ +WR I P+FKG+GY + +++ YI 
Sbjct: 62  GGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIG 120

Query: 174 SYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNIT-------------- 219
            YYN ++  A YY  SS T  LPW  C N WNT +C       N+T              
Sbjct: 121 IYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH 180

Query: 220 ---WTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKT 276
               +L  TSP+EE++  +VL++  S  + + G +   L  C+ + + V++  + +GVK+
Sbjct: 181 LLNHSLQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKS 238

Query: 277 SGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFS 336
           SGKVV+ TATFPY++L++L VRG TL GA+ G+++YL P W K+LE  VW DAA+QIF+S
Sbjct: 239 SGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYS 298

Query: 337 LGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSE 396
           LG  +G L+  ASYNKF+NNCY+D+++ S+ NC TS  +GFVIF++LG+MA     DVS 
Sbjct: 299 LGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSR 358

Query: 397 VAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPH 456
           VA D GP L F+ Y EA+  +P S  ++++FF MLI LGL + F  LE ++TA++DE  +
Sbjct: 359 VA-DHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGN 417

Query: 457 VWAKRRERFV-LAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWF 515
            W  +++ +V L V +  F   +   +  G Y + L++ YA   +++ ++ I  VA+ + 
Sbjct: 418 EWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYI 477

Query: 516 YGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSI 575
           YG   + +D++ MLGF P  F++ICW  +SP  + FI+   ++    +    Y YP W++
Sbjct: 478 YGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAV 537

Query: 576 ILGYCIGTSSFICIPTYIAYRLIITPG-TFKERIIKSITP 614
            +G+ +  SS +CIP Y  +RL  T G T  +R+  +  P
Sbjct: 538 AIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 577


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  488 bits (1255), Expect = e-138
 Identities = 238/583 (40%), Positives = 362/583 (62%), Gaps = 26/583 (4%)

Query: 51  PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICY 110
           P   +  +   ++P+  T     L +G    WG +++F+L+ +GYAV LGNVWRFPY+CY
Sbjct: 21  PVAPSSPEQNGAVPSEATKRDQNLKRGN---WGNQIEFVLTSVGYAVGLGNVWRFPYLCY 77

Query: 111 QNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAF 170
           +NGGGAF+ PY IM IF GIPLF+MEL+ GQ+   GC+ +WR I P+FKG+GY + +++ 
Sbjct: 78  RNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVST 136

Query: 171 YIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNIT----------- 219
           YI  YYN ++  A YY  SS T  LPW  C N WNT +C       N+T           
Sbjct: 137 YIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSN 196

Query: 220 ------WTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKG 273
                  +L  TSP+EE++  +VL++  S  + + G +   L  C+ + + V++  + +G
Sbjct: 197 LSHLLNHSLQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRG 254

Query: 274 VKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQI 333
           VK+SGKVV+ TATFPY++L++L VRG TL GA+ G+++YL P W K+LE  VW DAA+QI
Sbjct: 255 VKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQI 314

Query: 334 FFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNED 393
           F+SLG  +G L+  ASYNKF+NNCY+D+++ S+ NC TS  +GFVIF++LG+MA     D
Sbjct: 315 FYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVD 374

Query: 394 VSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDE 453
           VS VA D GP L F+ Y EA+  +P S  ++++FF MLI LGL + F  LE ++TA++DE
Sbjct: 375 VSRVA-DHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDE 433

Query: 454 FPHVWAKRRERFV-LAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAV 512
             + W  +++ +V L V +  F   +   +  G Y + L++ YA   +++ ++ I  VA+
Sbjct: 434 VGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAI 493

Query: 513 SWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPY 572
            + YG   + +D++ MLGF P  F++ICW  +SP  + FI+   ++    +    Y YP 
Sbjct: 494 MYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPG 553

Query: 573 WSIILGYCIGTSSFICIPTYIAYRLIITPG-TFKERIIKSITP 614
           W++ +G+ +  SS +CIP Y  +RL  T G T  +R+  +  P
Sbjct: 554 WAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 596


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  487 bits (1254), Expect = e-137
 Identities = 237/572 (41%), Positives = 359/572 (62%), Gaps = 26/572 (4%)

Query: 62  SIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPY 121
           ++P+  T     L +G    WG +++F+L+ +GYAV LGNVWRFPY+CY+NGGGAF+ PY
Sbjct: 86  AVPSEATKRDQNLKRGN---WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPY 142

Query: 122 TIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMA 181
            IM IF GIPLF+MEL+ GQ+   GC+ +WR I P+FKG+GY + +++ YI  YYN ++ 
Sbjct: 143 FIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVIC 201

Query: 182 WALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNIT-----------------WTLHS 224
            A YY  SS T  LPW  C N WNT +C       N+T                  +L  
Sbjct: 202 IAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQR 261

Query: 225 TSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVT 284
           TSP+EE++  +VL++  S  + + G +   L  C+ + + V++  + +GVK+SGKVV+ T
Sbjct: 262 TSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFT 319

Query: 285 ATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVL 344
           ATFPY++L++L VRG TL GA+ G+++YL P W K+LE  VW DAA+QIF+SLG  +G L
Sbjct: 320 ATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGL 379

Query: 345 LAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPS 404
           +  ASYNKF+NNCY+D+++ S+ NC TS  +GFVIF++LG+MA     DVS VA D GP 
Sbjct: 380 ITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVA-DHGPG 438

Query: 405 LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRER 464
           L F+ Y EA+  +P S  ++++FF MLI LGL + F  LE ++TA++DE  + W  +++ 
Sbjct: 439 LAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKT 498

Query: 465 FV-LAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCR 523
           +V L V +  F   +   +  G Y + L++ YA   +++ ++ I  VA+ + YG   + +
Sbjct: 499 YVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQ 558

Query: 524 DVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGT 583
           D++ MLGF P  F++ICW  +SP  + FI+   ++    +    Y YP W++ +G+ +  
Sbjct: 559 DIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMAL 618

Query: 584 SSFICIPTYIAYRLIITPG-TFKERIIKSITP 614
           SS +CIP Y  +RL  T G T  +R+  +  P
Sbjct: 619 SSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 650


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  483 bits (1244), Expect = e-136
 Identities = 250/599 (41%), Positives = 360/599 (60%), Gaps = 39/599 (6%)

Query: 23  ENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETW 82
           ENG+        GD+ +   I+ G    P+ G G       P    T    L    RETW
Sbjct: 7   ENGIYS----VSGDEKKGPLIAPGPDGAPAKGDG-------PVGLGTPGGRLAVPPRETW 55

Query: 83  GKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142
            +++DF++S +G+AV LGNVWRFPY+CY+NGGG FL+PY ++A+ GGIP+F++E++LGQ+
Sbjct: 56  TRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQF 115

Query: 143 HRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKN 202
            + G I++W  ICP+FKG+GYA  +I FY  +YY  ++AW  YYL+ SFT  LPW +C +
Sbjct: 116 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 174

Query: 203 SWNTGNCTNYFSED--------NITWT--LHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS 252
           +WNT +C   F  +        N+T        SP  EF+   VL++  S GL+  G ++
Sbjct: 175 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALN 232

Query: 253 WQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFY 312
           W++ LC++  + ++YF +WKGVK++GK+V+ TATFPY++L VLLVRG  LPGA  G+++Y
Sbjct: 233 WEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYY 292

Query: 313 LKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTS 372
           LKP+W KL    VWIDA  QIFFS   G G L A  SYN+FNNNCY            TS
Sbjct: 293 LKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG----------TS 342

Query: 373 FVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLI 432
           F +GFV+F++LG+MA  +   +S+VA ++GP L FI Y  A+  MP +  +A +FF ML+
Sbjct: 343 FFAGFVVFSILGFMAAEQGVHISKVA-ESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 401

Query: 433 TLGLDSTFAGLEGVITAVLDEFP--HVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVK 490
            LGLDS F G+EG IT +LD  P  + +  +RE  V      CF   L  +T GG YV +
Sbjct: 402 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 461

Query: 491 LLEEY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFL 549
           L + Y A+G  +L  A  E V V+W YG  +F  D+  M+G+ P  + + CW   +PL  
Sbjct: 462 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 521

Query: 550 LFI-ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607
           + I I + +   P +    Y YP+W   +G+    SS +C+P ++   L+   GT  ER
Sbjct: 522 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 580


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  482 bits (1240), Expect = e-136
 Identities = 250/576 (43%), Positives = 351/576 (60%), Gaps = 19/576 (3%)

Query: 51  PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICY 110
           PSPG         P T     AE    +RE W  K+DF+LSV G  V LGNVWRFPY+CY
Sbjct: 20  PSPGKS-------PGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCY 72

Query: 111 QNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAF 170
           +NGGGAFL+PY I     G+P+F++E+ +GQY   G I+ W KICP+F GIGYA  +I  
Sbjct: 73  KNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVS 132

Query: 171 YIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNC-TNYFSEDNITW----TLHST 225
            +  YY  I+AWA YYL  SF  +LPW  C +SWNT +C  +   ++   W    + + T
Sbjct: 133 LLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFT 192

Query: 226 SPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTA 285
           SP  EF+ R+VL +  S G+   G + W LALC++L++ V +F IWKGV+++GKVV+ TA
Sbjct: 193 SPVIEFWERNVLSL--SPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTA 250

Query: 286 TFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLL 345
           TFP+ +L VLLVRG TLPGA  G+ FYL P+  +L +  VWIDA  QIFFS     G + 
Sbjct: 251 TFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMT 310

Query: 346 AFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSL 405
           +  SYNK+  N Y+D ++   +N  TSFVSGF IF++LG+MA+ +  D+++VA ++GP L
Sbjct: 311 SLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVA-ESGPGL 369

Query: 406 LFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAK--RRE 463
            FI Y +A+  MP  TF++I+FF+ML+ LGLDS F  +EG IT+++D +P    K  RRE
Sbjct: 370 AFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRRE 429

Query: 464 RFVLAVVITCFFGSLVTLTFGGAYVVKLLEEY-ATGPAVLTVALIEAVAVSWFYGITQFC 522
            F+  V    +   L  +T GG YV +L + Y A+G  +L VA  E   ++W YG     
Sbjct: 430 IFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLY 489

Query: 523 RDVKEMLGFSPGWFWRICWVAISPLFLL-FIICSFLMSPPQLRLFQYNYPYWSIILGYCI 581
             +++M+G+ PG + +  W  I+P+  +   I S +   P      Y YP W+I LG+ +
Sbjct: 490 DGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSL 549

Query: 582 GTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 617
             SS +C+P  I  RL  T G F  R+   +TP  P
Sbjct: 550 ALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREP 585


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  482 bits (1240), Expect = e-136
 Identities = 250/576 (43%), Positives = 351/576 (60%), Gaps = 19/576 (3%)

Query: 51  PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICY 110
           PSPG         P T     AE    +RE W  K+DF+LSV G  V LGNVWRFPY+CY
Sbjct: 20  PSPGKS-------PGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCY 72

Query: 111 QNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAF 170
           +NGGGAFL+PY I     G+P+F++E+ +GQY   G I+ W KICP+F GIGYA  +I  
Sbjct: 73  KNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVS 132

Query: 171 YIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNC-TNYFSEDNITW----TLHST 225
            +  YY  I+AWA YYL  SF  +LPW  C +SWNT +C  +   ++   W    + + T
Sbjct: 133 LLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFT 192

Query: 226 SPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTA 285
           SP  EF+ R+VL +  S G+   G + W LALC++L++ V +F IWKGV+++GKVV+ TA
Sbjct: 193 SPVIEFWERNVLSL--SPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTA 250

Query: 286 TFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLL 345
           TFP+ +L VLLVRG TLPGA  G+ FYL P+  +L +  VWIDA  QIFFS     G + 
Sbjct: 251 TFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMT 310

Query: 346 AFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSL 405
           +  SYNK+  N Y+D ++   +N  TSFVSGF IF++LG+MA+ +  D+++VA ++GP L
Sbjct: 311 SLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVA-ESGPGL 369

Query: 406 LFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAK--RRE 463
            FI Y +A+  MP  TF++I+FF+ML+ LGLDS F  +EG IT+++D +P    K  RRE
Sbjct: 370 AFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRRE 429

Query: 464 RFVLAVVITCFFGSLVTLTFGGAYVVKLLEEY-ATGPAVLTVALIEAVAVSWFYGITQFC 522
            F+  V    +   L  +T GG YV +L + Y A+G  +L VA  E   ++W YG     
Sbjct: 430 IFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLY 489

Query: 523 RDVKEMLGFSPGWFWRICWVAISPLFLL-FIICSFLMSPPQLRLFQYNYPYWSIILGYCI 581
             +++M+G+ PG + +  W  I+P+  +   I S +   P      Y YP W+I LG+ +
Sbjct: 490 DGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSL 549

Query: 582 GTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP 617
             SS +C+P  I  RL  T G F  R+   +TP  P
Sbjct: 550 ALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREP 585


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  454 bits (1167), Expect = e-127
 Identities = 237/577 (41%), Positives = 348/577 (60%), Gaps = 49/577 (8%)

Query: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
           +R  W KK D+LLS+IGYAV LGNVWRFPY+ Y NGGGAFL+PY IM    G+PLF++E 
Sbjct: 35  DRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLEC 94

Query: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197
           +LGQ+   G +S+WR I P+F+G+G  + +I+ ++  YYN I+A++LYY+ +SF  +LPW
Sbjct: 95  SLGQFASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPW 153

Query: 198 TSCKNSWNTGNCT-------------------------NYFSEDNITWTLHSTS------ 226
            +C +SW+  NC+                         ++   +N T    S        
Sbjct: 154 KNC-SSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQL 212

Query: 227 PAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTAT 286
           P+E+++ +  LQ  RS G+ + G I W LALC++L + ++  +++KG+K+SGKVV+ TA 
Sbjct: 213 PSEQYWNKVALQ--RSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTAL 270

Query: 287 FPYIILSVLLVRGATLPGAWRGVLFYL--KPNWQKLLETGVWIDAAAQIFFSLGPGFGVL 344
           FPY++L +LLVRGATL GA +G+ +Y+  + N+ KL E  VW DAA QIF+SL   +G L
Sbjct: 271 FPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGL 330

Query: 345 LAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPS 404
           +A +SYNKF NNC+ DA+V  + NC+TS  +GF IF++LG+MA +  ++VS+V K +G  
Sbjct: 331 VALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVK-SGFD 389

Query: 405 LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRER 464
           L FI Y EA+A +P   F++I+FF ML+TLGLDS FA +E + T + D FP V  K R  
Sbjct: 390 LAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVP 449

Query: 465 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRD 524
             L   +  F   LV +T  G Y V L++ +  G  +L  A++E V + W YG  +F  D
Sbjct: 450 ITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIED 509

Query: 525 VKEMLGFSPGW----FWRICWVAISPLFLLFIICSFLMSPPQLRLFQYN---YPYWSIIL 577
            + M+G +  W    +WR CW  I+P+ L+ I   F+ S  Q     Y    YP W + L
Sbjct: 510 TEMMIG-AKRWIFWLWWRACWFVITPILLIAI---FIWSLVQFHRPNYGAIPYPDWGVAL 565

Query: 578 GYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITP 614
           G+C+     I IP     ++I   G   +R+I    P
Sbjct: 566 GWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRP 602


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  395 bits (1015), Expect = e-110
 Identities = 201/476 (42%), Positives = 292/476 (61%), Gaps = 18/476 (3%)

Query: 146 GCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWN 205
           G I++W  ICP+FKG+GYA  +I FY  +YY  ++AW  YYL+ SFT  LPW +C ++WN
Sbjct: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62

Query: 206 TGNCTNYFSED--------NITWT--LHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255
           T +C   F  +        N+T        SP  EF+   VL++  S GL+  G ++W++
Sbjct: 63  TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWEV 120

Query: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKP 315
            LC++  + ++YF +WKGVK++GK+V+ TATFPY++L VLLVRG  LPGA  G+++YLKP
Sbjct: 121 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 180

Query: 316 NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVS 375
           +W KL    VWIDA  QIFFS   G G L A  SYN+FNNNCY+DA++ +++N  TSF +
Sbjct: 181 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 240

Query: 376 GFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLG 435
           GFV+F++LG+MA  +   +S+VA ++GP L FI Y  A+  MP +  +A +FF ML+ LG
Sbjct: 241 GFVVFSILGFMAAEQGVHISKVA-ESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299

Query: 436 LDSTFAGLEGVITAVLDEFP--HVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE 493
           LDS F G+EG IT +LD  P  + +  +RE  V      CF   L  +T GG YV +L +
Sbjct: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359

Query: 494 EY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFI 552
            Y A+G  +L  A  E V V+W YG  +F  D+  M+G+ P  + + CW   +PL  + I
Sbjct: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419

Query: 553 -ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKER 607
            I + +   P +    Y YP+W   +G+    SS +C+P ++   L+   GT  ER
Sbjct: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 475


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  366 bits (939), Expect = e-101
 Identities = 204/619 (32%), Positives = 313/619 (50%), Gaps = 92/619 (14%)

Query: 53  PGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQN 112
           P  G D R    A   T+  E     R  W  K  ++L+ +G+ V LGNVWRFPY+C  +
Sbjct: 7   PNPGLDARIPSLAELETIEQE-EASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSH 65

Query: 113 GGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYI 172
           GGGAF++P+ I+ +  GIPL Y+E A+GQ  R G + +W  I P  KG+G A  + +F +
Sbjct: 66  GGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMV 125

Query: 173 ASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFY 232
             YYNTI++W ++YL +SF + LPW+ C  + N    T Y  E         +SP + F+
Sbjct: 126 GLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQ---TGYVDE------CARSSPVDYFW 176

Query: 233 TRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIIL 292
            R  L I  S  + D G I W + LC+   ++V+Y    +G++T+GK V++T+T PY++L
Sbjct: 177 YRETLNI--STSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVL 234

Query: 293 SVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNK 352
           ++ L+RG TL GA  G++F   PN  +L +   W+DA AQ+FFS    FG L++F+SYN 
Sbjct: 235 TIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNS 294

Query: 353 FNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNED------------------- 393
            +NNC +D+++ S++N  TS     V+++V+G+ A  R +D                   
Sbjct: 295 VHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGN 354

Query: 394 ----------------------------------VSEVAKDAGPSLLFITYAEAIANMPA 419
                                             +SE  +  G  L FI + EAI  MP 
Sbjct: 355 VTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTG--LAFIVFTEAITKMPL 412

Query: 420 STFFAIIFFLMLITLGLDSTFAGLEGVITAVLD--EFPHVWAKRRERFVLAVVI---TCF 474
           S  ++++FF+ML  LGL S F  +EGV+  + D    P  W K     VL  +I   T  
Sbjct: 413 SPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKE----VLTGLICLGTFL 468

Query: 475 FGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPG 534
            G + TL   G Y + LL+ YA    +L +A  E  +V + YG+ +F +D++ M+G  P 
Sbjct: 469 IGFIFTLN-SGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPN 527

Query: 535 WFWRICWVAISPLFLLFIICSFLMSPPQLRLF---------------QYNYPYWSIILGY 579
            FW++ W  +SPL +L I   F +      L                + +YP W  ++  
Sbjct: 528 IFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVV 587

Query: 580 CIGTSSFICIPTYIAYRLI 598
            +     + IP Y  Y+LI
Sbjct: 588 IVAGVPSLTIPGYAIYKLI 606


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  358 bits (919), Expect = 8e-99
 Identities = 195/547 (35%), Positives = 289/547 (52%), Gaps = 63/547 (11%)

Query: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
           ER  W  K  +LLS  G+AV LGN+WRFPY+C   GGGAFL+PY I  +F GIP+F++EL
Sbjct: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76

Query: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197
           A+GQ  R G + +W  I P   G+G     ++F I+ YYNTI+AW L+YL++SF   LPW
Sbjct: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136

Query: 198 TSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLAL 257
           +SC    N    T +  E         +S    F+ R  L I  +  + D G I W L +
Sbjct: 137 SSCPPDLNR---TGFVEE------CQGSSAVSYFWYRQTLNI--TADINDSGSIQWWLLI 185

Query: 258 CIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNW 317
           C+   + V+Y  + +G++T+GKV++ TA FPY++L++ L+RG TLPGA +G+++   PN 
Sbjct: 186 CLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNM 245

Query: 318 QKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGF 377
             L    VW+DAA QIFFSL   FG  +AFASYN   N+C +DA+V ++VN MTS  +  
Sbjct: 246 HILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASI 305

Query: 378 VIFTVLGYMAEMRNEDV----------------SEVAKDAGPSLL--------------- 406
            +F+VLG+ A    E                    +++D  P++L               
Sbjct: 306 AVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLP 365

Query: 407 --------------------FITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGV 446
                               F+ + E   +MP +  +A++FF ML TLGL + F  +E V
Sbjct: 366 LKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAV 425

Query: 447 ITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVAL 506
           IT +LD         +E     V + CF  +       G Y +++ + +A  P +L +A 
Sbjct: 426 ITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAF 485

Query: 507 IEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFL-LFIICSFLMSPPQLRL 565
           +E V V + YG+ +FC D+  M G  P  +WR+ W  +SPL L +F+    L+    LR 
Sbjct: 486 LEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRY 545

Query: 566 FQYNYPY 572
             +N  Y
Sbjct: 546 KAWNPKY 552


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  358 bits (918), Expect = 1e-98
 Identities = 203/599 (33%), Positives = 306/599 (51%), Gaps = 86/599 (14%)

Query: 79  RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138
           R  W   + F+ + I YAV LGNVWRFPY+C   GGG+FL+PY IM I  G+PL Y+ELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198
           +GQ  R G I  WR I P   G+G A  +++F+++ YYN I AWA +YL  SF D LPW+
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 199 SCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALC 258
            C  +   GN T Y  E          S  + F+ R  L I  S  LQ+ GG+ W+ ALC
Sbjct: 125 VCPLN---GNHTGYDEE------CEKASSTQYFWYRKTLNI--SPSLQENGGVQWEPALC 173

Query: 259 IMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQ 318
           ++L + V+Y  I +G +++GKVV+ TA+ PY +L + L+RG TL GA  G+++   P  +
Sbjct: 174 LLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIE 233

Query: 319 KLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV 378
           +L     WI+AA QIFFSLG GFG L+AFASYN+ +NNC + A++ S++N  TS  +  V
Sbjct: 234 QLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIV 293

Query: 379 IFTVLGYMAEMRNED---------------------------VSEVAKDAGPS------- 404
            F++ G+ A    E+                           V      A PS       
Sbjct: 294 TFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFP 353

Query: 405 -------------------LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEG 445
                              L FI Y EAI NM  S  +++++F ML+ LG+ S       
Sbjct: 354 QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAA 413

Query: 446 VITAVLD-EFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTV 504
           ++T + D +       +     L  ++ C  G + T+   G Y   +  +YA   ++L +
Sbjct: 414 ILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTME-AGNYWFDIFNDYAATLSLLLI 472

Query: 505 ALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFL------- 557
            L+E +AV + YG+ +F  D+K M G +  W+W++ W  +SPL ++ +   +L       
Sbjct: 473 VLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTG 532

Query: 558 ------MSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIK 610
                     Q +L   +YP +++ +   +  SS +CIP       +   GTF +R +K
Sbjct: 533 TLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP-------LAALGTFVQRRLK 584


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  338 bits (867), Expect = 9e-93
 Identities = 187/595 (31%), Positives = 313/595 (52%), Gaps = 90/595 (15%)

Query: 76  QGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYM 135
           + ER  W  K+ ++L+ +G++V LGNVWRFPY+C +NGGGA+LLPY I+ +  GIPLF++
Sbjct: 58  EDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFL 117

Query: 136 ELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQL 195
           EL++GQ  R G I +W  I P   GIG+A C++ +++A YYN I+ W+L+Y   SF   L
Sbjct: 118 ELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPL 177

Query: 196 PWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255
           PW  C       N ++ F E         +S    ++ R  L I  S  + + GG++W++
Sbjct: 178 PWDQCPL---VKNASHTFVEPEC----EQSSATTYYWYREALNI--SSSISESGGLNWKM 228

Query: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKP 315
            +C++  + ++  ++ KG+++SGK+++ ++ FPY++L   L+R   L G+  G+     P
Sbjct: 229 TICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTP 288

Query: 316 NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNC------------YQDALV 363
             + +LE  VW +AA Q+FF+LG GFG ++AF+SYNK +NNC            +   L 
Sbjct: 289 KLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLA 348

Query: 364 TSVV-------------NCMTSFVSGFVIFTVLGYMAE---------------------- 388
           T VV              C+T      + F  +G +++                      
Sbjct: 349 TLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYD 408

Query: 389 ----MRNED----------VSEVAKDA--GPSLLFITYAEAIANMPASTFFAIIFFLMLI 432
               ++ E+          + E    A  G  L FI + EA+ + PAS F++++FFLML+
Sbjct: 409 IIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLV 468

Query: 433 TLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492
            LGL S F  +EG++T ++D F      R+E   +   +  F   L+ +   G Y V + 
Sbjct: 469 NLGLGSMFGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMF 524

Query: 493 EEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFI 552
           ++Y+    +L V ++E +AV + YGI +F  D+K+MLGF+P  ++   W  ISPL LL +
Sbjct: 525 DDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSL 584

Query: 553 ICSFL----MSPPQLRLF--------QYNYPYWSIILGYCIGTSSFICIPTYIAY 595
           + + +    +SPP    +          +YP W +++  C+    F  +P  + +
Sbjct: 585 LIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVV--CVSLVVFAILPVPVVF 637


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  308 bits (788), Expect = 1e-83
 Identities = 187/599 (31%), Positives = 283/599 (47%), Gaps = 123/599 (20%)

Query: 79  RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138
           R  W   + F+ + I YAV LGNVWRFPY+C   GGG+FL+PY IM I  G+PL Y+ELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198
           +GQ  R G I  WR I P   G+G A  +++F+++ YYN I AWA +YL  SF D LPW+
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 199 SCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALC 258
            C  +   GN T Y  E          S  + F+ R  L I  S  LQ+ GG+ W+ ALC
Sbjct: 125 VCPLN---GNHTGYDEE------CEKASSTQYFWYRKTLNI--SPSLQENGGVQWEPALC 173

Query: 259 IMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQ 318
           ++L + V+Y  I +G +++GK+                                     +
Sbjct: 174 LLLAWLVVYLCILRGTESTGKI-------------------------------------E 196

Query: 319 KLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV 378
           +L     WI+AA QIFFSLG GFG L+AFASYN+ +NNC + A++ S++N  TS  +  V
Sbjct: 197 QLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIV 256

Query: 379 IFTVLGYMAEMRNED---------------------------VSEVAKDAGPS------- 404
            F++ G+ A    E+                           V      A PS       
Sbjct: 257 TFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFP 316

Query: 405 -------------------LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEG 445
                              L FI Y EAI NM  S  +++++F ML+ LG+ S       
Sbjct: 317 QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAA 376

Query: 446 VITAVLD-EFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTV 504
           ++T + D +       +     L  ++ C  G + T+   G Y   +  +YA   ++L +
Sbjct: 377 ILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTME-AGNYWFDIFNDYAATLSLLLI 435

Query: 505 ALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFL------- 557
            L+E +AV + YG+ +F  D+K M G +  W+W++ W  +SPL ++ +   +L       
Sbjct: 436 VLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTG 495

Query: 558 ------MSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIK 610
                     Q +L   +YP +++ +   +  SS +CIP       +   GTF +R +K
Sbjct: 496 TLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP-------LAALGTFVQRRLK 547


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  303 bits (776), Expect = 3e-82
 Identities = 174/560 (31%), Positives = 291/560 (51%), Gaps = 71/560 (12%)

Query: 73  ELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPL 132
           EL   +R  W  K+ ++L+ IG++V LGN+WRFPY+C +NGGGA+L+PY ++ I  GIPL
Sbjct: 54  ELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPL 113

Query: 133 FYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFT 192
           F++ELA+GQ  R G I +W  ICP   GIG++ CI+  ++  YYN I+ W+++Y   SF 
Sbjct: 114 FFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQ 173

Query: 193 DQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS 252
             LPW+ C    N G+     +E         +S    F+ R  L I  S  + + GG++
Sbjct: 174 YPLPWSECPVVRN-GSVAVVEAE------CEKSSATTYFWYREALDI--SDSISESGGLN 224

Query: 253 WQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFY 312
           W++ LC+++ ++++  ++ KG+++SGKV++ ++ FPY++L+  LVRG  L GA  G+L  
Sbjct: 225 WKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHM 284

Query: 313 LKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTS 372
             P   K+L+  VW +AA Q+FF+LG GFG ++AF+SYNK +NNC+ DA + S +N  TS
Sbjct: 285 FTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTS 344

Query: 373 FVSGFVIFTVLGYMAEMRNE--------------DVSEVAKDAGPSLL---------FIT 409
            ++  V+F VLG+ A + NE              + + +++D  P  +         ++ 
Sbjct: 345 VLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYME 404

Query: 410 YAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPH-----VWAKRRER 464
               I  +    F A+     L+   LD +  G      A  +   H      W+     
Sbjct: 405 MYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFL 464

Query: 465 FVLAVVITCFFGSLVTLTFG------------------GAYVVKLLEEYATGPAVLTV-- 504
            ++ + +    G++  +T                     A++V LL    +G   +T+  
Sbjct: 465 MLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFD 524

Query: 505 -----------ALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFII 553
                       ++E +AV+W YG  +F +++ EMLGF P  F+   W  +SPL +  + 
Sbjct: 525 DYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLT 584

Query: 554 CSFLMSPPQLRLFQYNYPYW 573
            + ++   QL +    Y  W
Sbjct: 585 TASII---QLGVTPPGYSAW 601


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  272 bits (696), Expect = 6e-73
 Identities = 160/542 (29%), Positives = 273/542 (50%), Gaps = 90/542 (16%)

Query: 129 GIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLI 188
           GIPLF++EL++GQ  R G I +W  I P   GIG+A C++ +++A YYN I+ W+L+Y  
Sbjct: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63

Query: 189 SSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDL 248
            SF   LPW  C       N ++ F E         +S    ++ R  L I  S  + + 
Sbjct: 64  QSFQQPLPWDQCPL---VKNASHTFVEPEC----EQSSATTYYWYREALNI--SSSISES 114

Query: 249 GGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRG 308
           GG++W++ +C++  + ++  ++ KG+++SGK+++ ++ FPY++L   L+R   L G+  G
Sbjct: 115 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 174

Query: 309 VLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNC----------- 357
           +     P  + +LE  VW +AA Q+FF+LG GFG ++AF+SYNK +NNC           
Sbjct: 175 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 234

Query: 358 -YQDALVTSVV-------------NCMTSFVSGFVIFTVLGYMAE--------------- 388
            +   L T VV              C+T      + F  +G +++               
Sbjct: 235 FFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAE 294

Query: 389 -----------MRNED----------VSEVAKDA--GPSLLFITYAEAIANMPASTFFAI 425
                      ++ E+          + E    A  G  L FI + EA+ + PAS F+++
Sbjct: 295 DYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSV 354

Query: 426 IFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGG 485
           +FFLML+ LGL S F  +EG++T ++D F      R+E   +   +  F   L+ +   G
Sbjct: 355 MFFLMLVNLGLGSMFGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSG 410

Query: 486 AYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAIS 545
            Y V + ++Y+    +L V ++E +AV + YGI +F  D+K+MLGF+P  ++   W  IS
Sbjct: 411 NYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYIS 470

Query: 546 PLFLLFIICSFL----MSPPQLRLF--------QYNYPYWSIILGYCIGTSSFICIPTYI 593
           PL LL ++ + +    +SPP    +          +YP W +++  C+    F  +P  +
Sbjct: 471 PLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVV--CVSLVVFAILPVPV 528

Query: 594 AY 595
            +
Sbjct: 529 VF 530


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  226 bits (576), Expect = 5e-59
 Identities = 154/591 (26%), Positives = 269/591 (45%), Gaps = 87/591 (14%)

Query: 79  RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138
           R  W  K +++L+ +G+++    +WRF Y+   +GG +F   Y  M    G+PL ++E+A
Sbjct: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162

Query: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198
            GQ  R G + +W+ I P   G+GY+  ++ F +  Y+N + +W ++Y+  SF   +PW 
Sbjct: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222

Query: 199 SCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALC 258
            C  + N+      F  +        T+P+  F+ +  L+   S  ++D G   + L L 
Sbjct: 223 KCPLTMNSSG----FDPE-----CERTTPSIYFWYQQALK--ASDRIEDGGSPVYSLVLP 271

Query: 259 IMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQ 318
             L + ++   +  G+K++GKV++V    P  I+    +R   L GA  G+   +     
Sbjct: 272 FFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKIS 331

Query: 319 KLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV 378
            +    VW  A  Q+  + G G G + + ASY   +NNC  DA + SV+N +T  V    
Sbjct: 332 DVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSF 391

Query: 379 IFTVLGYMAEM-------RNEDV-------SEVAKDAGP--SLLF--------------- 407
            F VLG+ A +       RN ++        ++  DA P  +LL+               
Sbjct: 392 NFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQ 451

Query: 408 ------------------------------ITYAEAIANMPASTFFAIIFFLMLITLGLD 437
                                         +++ EA++ +P S F++ IFFLML+ +GL 
Sbjct: 452 HIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLS 511

Query: 438 STFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYAT 497
           S    ++G+IT + D F   + K  +  ++ V +  F   L      G+Y ++LL +Y  
Sbjct: 512 SAIGIMQGIITPLQDTF-SFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWI 570

Query: 498 GPAVLTVALIEAVAVSWFYGITQFCRDVKEMLG--FSP--GWFW-RICWVAISPLFLLFI 552
              ++ V + E +AVSW YG  +F  D+  +LG   SP  GW W  +C V +  +F+  +
Sbjct: 571 VFPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMM 630

Query: 553 ICSFLMSPPQLRLFQYN--------YPYWSIILGYCIGTSSFICIPTYIAY 595
           +    M P     +  +        YP W+++L   +     + IP Y  Y
Sbjct: 631 V-HLCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVY 680


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  180 bits (457), Expect = 3e-45
 Identities = 82/221 (37%), Positives = 136/221 (61%), Gaps = 12/221 (5%)

Query: 76  QGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYM 135
           + ER  W  K+ ++L+ +G++V LGNVWRFPY+C +NGGGA+LLPY I+ +  GIPLF++
Sbjct: 58  EDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFL 117

Query: 136 ELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQL 195
           EL++GQ  R G I +W  I P   GIG+A C++ +++A YYN I+ W+L+Y   SF   L
Sbjct: 118 ELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPL 177

Query: 196 PWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255
           PW  C       N ++ F E         +S    ++ R  L I  S  + + GG++W++
Sbjct: 178 PWDQCP---LVKNASHTFVEPE----CEQSSATTYYWYREALNI--SSSISESGGLNWKM 228

Query: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLL 296
            +C++  + ++  ++ KG+++SGKV  +    P++IL + +
Sbjct: 229 TICLLAAWVMVCLAMIKGIQSSGKVSMLE---PFLILLITI 266


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  179 bits (455), Expect = 5e-45
 Identities = 87/187 (46%), Positives = 113/187 (60%), Gaps = 12/187 (6%)

Query: 51  PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICY 110
           PSPG         P T     AE    +RE W  K+DF+LSV G  V LGNVWRFPY+CY
Sbjct: 20  PSPGKS-------PGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCY 72

Query: 111 QNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAF 170
           +NGGGAFL+PY I     G+P+F++E+ +GQY   G I+ W KICP+F GIGYA  +I  
Sbjct: 73  KNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVS 132

Query: 171 YIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNC-TNYFSEDNITW----TLHST 225
            +  YY  I+AWA YYL  SF  +LPW  C +SWNT +C  +   ++   W    + + T
Sbjct: 133 LLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFT 192

Query: 226 SPAEEFY 232
           SP  EF+
Sbjct: 193 SPVIEFW 199


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.141    0.458 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,154,933
Number of Sequences: 37866
Number of extensions: 1120403
Number of successful extensions: 3243
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 3054
Number of HSP's gapped (non-prelim): 74
length of query: 630
length of database: 18,247,518
effective HSP length: 108
effective length of query: 522
effective length of database: 14,157,990
effective search space: 7390470780
effective search space used: 7390470780
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.