Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4506755
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506755 retinoid X receptor, alpha [Homo sapiens]
(462 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 940 0.0
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 639 0.0
gi|11415052 retinoid X receptor, beta [Homo sapiens] 627 e-180
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 283 2e-76
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 278 6e-75
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 274 1e-73
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 268 6e-72
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 268 6e-72
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 267 2e-71
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 265 9e-71
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 265 9e-71
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 264 1e-70
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 263 2e-70
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 219 3e-57
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 219 3e-57
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 219 3e-57
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 219 3e-57
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 219 3e-57
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 215 8e-56
gi|238550159 estrogen-related receptor beta [Homo sapiens] 214 1e-55
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 214 1e-55
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 208 7e-54
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 205 8e-53
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 204 1e-52
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 204 1e-52
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 201 1e-51
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 197 1e-50
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 188 1e-47
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 187 1e-47
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 187 1e-47
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 940 bits (2429), Expect = 0.0
Identities = 462/462 (100%), Positives = 462/462 (100%)
Query: 1 MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING 60
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
Sbjct: 1 MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING 60
Query: 61 MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP 120
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
Sbjct: 61 MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP 120
Query: 121 AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID 180
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
Sbjct: 121 AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID 180
Query: 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL 240
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
Sbjct: 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL 240
Query: 241 AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
Sbjct: 241 AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
Query: 301 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 360
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
Sbjct: 301 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 360
Query: 361 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL 420
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
Sbjct: 361 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL 420
Query: 421 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT 462
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
Sbjct: 421 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT 462
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 639 bits (1648), Expect = 0.0
Identities = 327/448 (72%), Positives = 367/448 (81%), Gaps = 15/448 (3%)
Query: 26 GSMAAPSLHPSLGPGIGSPGQLH-----SPIS---TLSS---PINGMGPPFSVISSPMGP 74
G + S+ PS G P H +P+S TLS+ P+N +G P+ VI+S MGP
Sbjct: 20 GHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGP 79
Query: 75 HSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHI 134
S ++ P + + +N VSSSEDIKP GL G+ + +PS + S KHI
Sbjct: 80 PSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMN-YPSTSPGSLVKHI 138
Query: 135 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQK 194
CAICGDRSSGKHYGVYSCEGCKGFFKRT+RKDL YTCRDNKDCLIDKRQRNRCQYCRYQK
Sbjct: 139 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQK 198
Query: 195 CLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANM 254
CL MGMKREAVQEERQR ++R E+E E +S +EDMPVERILEAELAVEPKTE+Y + NM
Sbjct: 199 CLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNM 258
Query: 255 GLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFS 314
+S NDPVTNIC AADKQLFTLVEWAKRIPHFS+L L+DQVILLRAGWNELLIASFS
Sbjct: 259 ---ENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFS 315
Query: 315 HRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIV 374
HRS++V+DGILLATGLHVHR+SAHSAGVG+IFDRVLTELVSKM+DMQMDK+ELGCLRAIV
Sbjct: 316 HRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIV 375
Query: 375 LFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLE 434
LFNPD+KGLSNP+EVE LREKVYA+LEAY K KYPEQPGRFAKLLLRLPALRSIGLKCLE
Sbjct: 376 LFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLE 435
Query: 435 HLFFFKLIGDTPIDTFLMEMLEAPHQMT 462
HLFFFKLIGDTPIDTFLMEMLE P Q+T
Sbjct: 436 HLFFFKLIGDTPIDTFLMEMLETPLQIT 463
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 627 bits (1616), Expect = e-180
Identities = 332/461 (72%), Positives = 362/461 (78%), Gaps = 19/461 (4%)
Query: 12 STQVNSSLTSPTGRG----SMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSV 67
S +SS +P +G S P L PS P +G G P P +G PF V
Sbjct: 80 SRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPP----PMPPPPLGSPFPV 135
Query: 68 ISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMN-PVSSS---EDIKPP-LGLNGVLKVPAH 122
ISS MG + P P SPQ++S ++ P S ED+KPP LG+ G L P
Sbjct: 136 ISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRG-LHCPPP 194
Query: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
P G A K +CAICGDRSSGKHYGVYSCEGCKGFFKRT+RKDLTY+CRDNKDC +DKR
Sbjct: 195 PGGPGAG--KRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKR 252
Query: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAV 242
QRNRCQYCRYQKCLA GMKREAVQEERQRGKD+ + + E A E+MPV+RILEAELAV
Sbjct: 253 QRNRCQYCRYQKCLATGMKREAVQEERQRGKDK-DGDGEGAGGAPEEMPVDRILEAELAV 311
Query: 243 EPKTETYVEA--NMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
E K++ VE G + SSPNDPVTNICQAADKQLFTLVEWAKRIPHFS LPLDDQVIL
Sbjct: 312 EQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVIL 371
Query: 301 LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 360
LRAGWNELLIASFSHRSI V+DGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
Sbjct: 372 LRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 431
Query: 361 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL 420
+MDKTELGCLRAI+LFNPD+KGLSNP+EVE LREKVYASLE YCK KYPEQ GRFAKLLL
Sbjct: 432 RMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLL 491
Query: 421 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQM 461
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQ+
Sbjct: 492 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQL 532
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 283 bits (725), Expect = 2e-76
Identities = 155/396 (39%), Positives = 222/396 (56%), Gaps = 10/396 (2%)
Query: 64 PFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHP 123
P + G + P P G G+P +P P P G P P
Sbjct: 11 PQDEVPGSQGSQASQAPPVP--GPPPGAPH--TPQTPGQGGPASTPAQTAAGGQGGPGGP 66
Query: 124 SGNMASFTKHI-CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
+ +HI C +CGD+SSGKHYG ++CEGCK FFKR+VR++L+YTCR N++C ID+
Sbjct: 67 GSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQH 126
Query: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAV 242
RN+CQYCR +KCL +GM+REAVQ R + T+ + + L +++
Sbjct: 127 HRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTN--GDPLNCHSYLSGYISL 184
Query: 243 EPKTETYVEANMGLNPSSPND--PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
+ E Y + G PN+ + NIC+ A + LF+ VEWA+ IP F +L + DQV L
Sbjct: 185 LLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVAL 244
Query: 301 LRAGWNELLIASFSHRSIAVKDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRD 359
LR W+EL + + + S+ + +L A GLH SA R+ E V K++
Sbjct: 245 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 304
Query: 360 MQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLL 419
+ +D E CL+AIVLF D+ GLS+ A VE+L+EK +LE Y + +YP QP RF KLL
Sbjct: 305 LHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLL 364
Query: 420 LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455
LRLP+LR++ +E LFF +L+G TPI+T + +ML
Sbjct: 365 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 400
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 278 bits (712), Expect = 6e-75
Identities = 144/336 (42%), Positives = 206/336 (61%), Gaps = 5/336 (1%)
Query: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
P G+ S C +CGD+SSGKHYG ++CEGCK FFKR+VR++LTYTCR N++C ID+
Sbjct: 74 PPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQH 133
Query: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAV 242
RN+CQYCR +KCL +GM+REAVQ R N + T+ + + L +++
Sbjct: 134 HRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTN--GDPLNGHCYLSGYISL 191
Query: 243 EPKTETYVEANMGLNPSSPND--PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
+ E Y + G PN+ + NIC+ A + LF+ VEWA+ IP F +L + DQV L
Sbjct: 192 LLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSL 251
Query: 301 LRAGWNELLIASFSHRSIAVKDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRD 359
LR W+EL + + + S+ + +L A GLH SA R+ E V K++
Sbjct: 252 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 311
Query: 360 MQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLL 419
+ +D E CL+AIVLF D+ GLS+ A +E+L+EK +LE Y + +YP QP RF KLL
Sbjct: 312 LHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLL 371
Query: 420 LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455
LRLP+LR++ +E LFF +L+G TPI+T + +ML
Sbjct: 372 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 274 bits (700), Expect = 1e-73
Identities = 141/335 (42%), Positives = 196/335 (58%), Gaps = 14/335 (4%)
Query: 135 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQK 194
C +CGD+SSGKHYGV++CEGCK FFKR++R++L+YTCR N+DC ID+ RN+CQYCR +K
Sbjct: 56 CVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKK 115
Query: 195 CLAMGMKREAVQEER-----------QRGKDRNE--NEVESTSSANEDMPVERILEAELA 241
C +GM++EAVQ R G V S PV ++ L
Sbjct: 116 CFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLR 175
Query: 242 VEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILL 301
EP G + + N+C+ A + LF+ VEWA+ P F ELP+ DQV LL
Sbjct: 176 AEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALL 235
Query: 302 RAGWNELLIASFSHRSIAVKDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM 360
R W+EL + + + ++ + +L A GLH +A A R E V K+ +
Sbjct: 236 RLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRL 295
Query: 361 QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL 420
Q+D E GCL+AI LF PD+ GLS+PA VE+L+EK +L Y + +YP QP RF +LLL
Sbjct: 296 QVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLL 355
Query: 421 RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455
RLPALR++ + LFF +L+G TPI+T + +ML
Sbjct: 356 RLPALRAVPASLISQLFFMRLVGKTPIETLIRDML 390
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 268 bits (686), Expect = 6e-72
Identities = 153/366 (41%), Positives = 215/366 (58%), Gaps = 20/366 (5%)
Query: 100 PVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFF 159
PV SS D P G N L P + G A +CAICGDR++GKHYG SC+GCKGFF
Sbjct: 11 PVESSYDTSPSEGTN--LNAP-NSLGVSA-----LCAICGDRATGKHYGASSCDGCKGFF 62
Query: 160 KRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENE 219
+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +KC GMK+EAVQ ER R R +
Sbjct: 63 RRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSY 122
Query: 220 VESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTL 279
+S+ + + +L+AE+ T N + + ++C++ +QL L
Sbjct: 123 EDSSLPS-----INALLQAEVLSRQITSPVSGINGDIRAKKIAS-IADVCESMKEQLLVL 176
Query: 280 VEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHS 339
VEWAK IP F ELPLDDQV LLRA E L+ + RS+ KD +LL V R+
Sbjct: 177 VEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPEL 236
Query: 340 AGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYAS 399
A + + R+L ELV +++Q+D E L+AI+ F+PD+KGLS+P +++ LR +V S
Sbjct: 237 AEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVS 296
Query: 400 LEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML---- 455
LE Y + + GRF +LLL LP L+SI + +E + F KL G ID L EML
Sbjct: 297 LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGS 356
Query: 456 --EAPH 459
+APH
Sbjct: 357 PSDAPH 362
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 268 bits (686), Expect = 6e-72
Identities = 153/366 (41%), Positives = 215/366 (58%), Gaps = 20/366 (5%)
Query: 100 PVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFF 159
PV SS D P G N L P + G A +CAICGDR++GKHYG SC+GCKGFF
Sbjct: 11 PVESSYDTSPSEGTN--LNAP-NSLGVSA-----LCAICGDRATGKHYGASSCDGCKGFF 62
Query: 160 KRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENE 219
+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +KC GMK+EAVQ ER R R +
Sbjct: 63 RRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSY 122
Query: 220 VESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTL 279
+S+ + + +L+AE+ T N + + ++C++ +QL L
Sbjct: 123 EDSSLPS-----INALLQAEVLSRQITSPVSGINGDIRAKKIAS-IADVCESMKEQLLVL 176
Query: 280 VEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHS 339
VEWAK IP F ELPLDDQV LLRA E L+ + RS+ KD +LL V R+
Sbjct: 177 VEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPEL 236
Query: 340 AGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYAS 399
A + + R+L ELV +++Q+D E L+AI+ F+PD+KGLS+P +++ LR +V S
Sbjct: 237 AEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVS 296
Query: 400 LEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML---- 455
LE Y + + GRF +LLL LP L+SI + +E + F KL G ID L EML
Sbjct: 297 LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGS 356
Query: 456 --EAPH 459
+APH
Sbjct: 357 PSDAPH 362
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 267 bits (682), Expect = 2e-71
Identities = 150/356 (42%), Positives = 211/356 (59%), Gaps = 14/356 (3%)
Query: 100 PVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFF 159
PV SS D P G N L P + G A +CAICGDR++GKHYG SC+GCKGFF
Sbjct: 11 PVESSYDTSPSEGTN--LNAP-NSLGVSA-----LCAICGDRATGKHYGASSCDGCKGFF 62
Query: 160 KRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENE 219
+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +KC GMK+EAVQ ER R R +
Sbjct: 63 RRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSY 122
Query: 220 VESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTL 279
+S+ + + +L+AE+ T N + + ++C++ +QL L
Sbjct: 123 EDSSLPS-----INALLQAEVLSRQITSPVSGINGDIRAKKIAS-IADVCESMKEQLLVL 176
Query: 280 VEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHS 339
VEWAK IP F ELPLDDQV LLRA E L+ + RS+ KD +LL V R+
Sbjct: 177 VEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPEL 236
Query: 340 AGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYAS 399
A + + R+L ELV +++Q+D E L+AI+ F+PD+KGLS+P +++ LR +V S
Sbjct: 237 AEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVS 296
Query: 400 LEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455
LE Y + + GRF +LLL LP L+SI + +E + F KL G ID L EML
Sbjct: 297 LEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEML 352
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 265 bits (676), Expect = 9e-71
Identities = 141/332 (42%), Positives = 202/332 (60%), Gaps = 12/332 (3%)
Query: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193
+CAICGDR++GKHYG SC+GCKGFF+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEAN 253
KC GMK+EAVQ ER R R + +S+ + + +L+AE+ T N
Sbjct: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPS-----INALLQAEVLSRQITSPVSGIN 173
Query: 254 MGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASF 313
+ + ++C++ +QL LVEWAK IP F ELPLDDQV LLRA E L+
Sbjct: 174 GDIRAKKIAS-IADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGA 232
Query: 314 SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAI 373
+ RS+ KD +LL V R+ A + + R+L ELV +++Q+D E L+AI
Sbjct: 233 TKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAI 292
Query: 374 VLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCL 433
+ F+PD+KGLS+P +++ LR +V SLE Y + + GRF +LLL LP L+SI + +
Sbjct: 293 IFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMI 352
Query: 434 EHLFFFKLIGDTPIDTFLMEML------EAPH 459
E + F KL G ID L EML +APH
Sbjct: 353 EQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 265 bits (676), Expect = 9e-71
Identities = 141/332 (42%), Positives = 202/332 (60%), Gaps = 12/332 (3%)
Query: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193
+CAICGDR++GKHYG SC+GCKGFF+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEAN 253
KC GMK+EAVQ ER R R + +S+ + + +L+AE+ T N
Sbjct: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPS-----INALLQAEVLSRQITSPVSGIN 173
Query: 254 MGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASF 313
+ + ++C++ +QL LVEWAK IP F ELPLDDQV LLRA E L+
Sbjct: 174 GDIRAKKIAS-IADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGA 232
Query: 314 SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAI 373
+ RS+ KD +LL V R+ A + + R+L ELV +++Q+D E L+AI
Sbjct: 233 TKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAI 292
Query: 374 VLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCL 433
+ F+PD+KGLS+P +++ LR +V SLE Y + + GRF +LLL LP L+SI + +
Sbjct: 293 IFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMI 352
Query: 434 EHLFFFKLIGDTPIDTFLMEML------EAPH 459
E + F KL G ID L EML +APH
Sbjct: 353 EQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 264 bits (675), Expect = 1e-70
Identities = 138/322 (42%), Positives = 199/322 (61%), Gaps = 7/322 (2%)
Query: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193
+CAICGDR++GKHYG SC+GCKGFF+R++RK Y+CR ++ C++DK +RN+C+YCR +
Sbjct: 48 LCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLR 107
Query: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEAN 253
KC GMK+EAVQ ER R R ST + + + +AE+ + + ++
Sbjct: 108 KCFRAGMKKEAVQNERDRISTR-----RSTFDGSNIPSINTLAQAEVRSRQISVSSPGSS 162
Query: 254 MGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASF 313
+N + ++C++ +QL LVEWAK IP F ELPLDDQV LLRA E L+
Sbjct: 163 TDINVKKIAS-IGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGA 221
Query: 314 SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAI 373
+ RS+ KD +LL +HRNS + + +RVL ELV +++Q+D E CL+AI
Sbjct: 222 TKRSMMYKDILLLGNNYVIHRNSC-EVEISRVANRVLDELVRPFQEIQIDDNEYACLKAI 280
Query: 374 VLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCL 433
V F+PD+KGLS+P +++ +R +V LE Y + + GRF +LLL LP L+SI + +
Sbjct: 281 VFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMI 340
Query: 434 EHLFFFKLIGDTPIDTFLMEML 455
E + F KL G ID L EML
Sbjct: 341 EQIQFVKLFGMVKIDNLLQEML 362
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 263 bits (672), Expect = 2e-70
Identities = 138/322 (42%), Positives = 198/322 (61%), Gaps = 6/322 (1%)
Query: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193
+CAICGDR++GKHYG SC+GCKGFF+R+VRK+ Y+CR ++ C++DK +RN+C+YCR +
Sbjct: 59 LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLK 118
Query: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEAN 253
KC GMK+EAVQ ER R R + +S+ + + +L+AE+ T N
Sbjct: 119 KCFRAGMKKEAVQNERDRISTRRSSYEDSSLPS-----INALLQAEVLSRQITSPVSGIN 173
Query: 254 MGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASF 313
+ + ++C++ +QL LVEWAK IP F ELPLDDQV LLRA E L+
Sbjct: 174 GDIRAKKIAS-IADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGA 232
Query: 314 SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAI 373
+ RS+ KD +LL V R+ A + + R+L ELV +++Q+D E L+AI
Sbjct: 233 TKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAI 292
Query: 374 VLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCL 433
+ F+PD+KGLS+P +++ LR +V SLE Y + + GRF +LLL LP L+SI + +
Sbjct: 293 IFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMI 352
Query: 434 EHLFFFKLIGDTPIDTFLMEML 455
E + F KL G ID L EML
Sbjct: 353 EQIQFIKLFGMAKIDNLLQEML 374
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 219 bits (559), Expect = 3e-57
Identities = 132/364 (36%), Positives = 190/364 (52%), Gaps = 43/364 (11%)
Query: 135 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD-CLIDKRQRNRCQYCRYQ 193
C +CGD SSGKHYG+Y+C GC GFFKR+VR+ L Y C+ C +DK RN+CQ CR +
Sbjct: 47 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLK 106
Query: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILE-AELAVEPKTETYVEA 252
KCL GM ++AVQ ERQ + + ++S S E P + A P+ T + A
Sbjct: 107 KCLQAGMNQDAVQNERQP-RSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSA 165
Query: 253 NMGL-------------------------------NPSSPNDPVTN--------ICQAAD 273
L +P P+ P ++ I + +
Sbjct: 166 ARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSA 225
Query: 274 KQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVH 333
+ LF V+WAK +P FS LP DQVILL W+EL + S+ + LLA
Sbjct: 226 RLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASA 285
Query: 334 RNSAHSA-GVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEAL 392
A + ++ RVL E +S+ R + +D TE C++A+VLF P+++GL +P VEAL
Sbjct: 286 AGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEAL 345
Query: 393 REKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLM 452
+++ L + K +P QP RF KLLL LP+LR I + +E LFF K IG+TP++ L
Sbjct: 346 QDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLC 405
Query: 453 EMLE 456
+M +
Sbjct: 406 DMFK 409
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 219 bits (559), Expect = 3e-57
Identities = 145/447 (32%), Positives = 229/447 (51%), Gaps = 40/447 (8%)
Query: 20 TSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSV 79
T P+ S+ H S G GS S ST++ NG+ P P+
Sbjct: 18 TEPSSPASLTDSVNHHSPG---GSSDASGSYSSTMNGHQNGLDSP------PL------Y 62
Query: 80 PTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICG 139
P+ P LG GS + + SS+ P +L S K +C +CG
Sbjct: 63 PSAPILG---GSGPVRKLYDDCSSTIVEDPQTKCEYMLN----------SMPKRLCLVCG 109
Query: 140 DRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMG 199
D +SG HYGV SCE CK FFKRT++ ++ Y+C +C I KR+R CQ CR+ KCL +G
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 200 MKREAVQEERQRG---KDRNENEVESTSSANEDM------PVERILEAELAVEPKTETYV 250
M +E V+ +R RG K + + E++ N + P +I+ L EP+ + Y
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE-KIYA 228
Query: 251 EANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLI 310
+ + P S +T +C AD++L ++ WAK IP FS L L DQ+ LL++ W E+LI
Sbjct: 229 MPDPTV-PDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILI 287
Query: 311 ASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCL 370
+RS++ +D ++ A + + + AG+ + + +L +LV K + M+++K E L
Sbjct: 288 LGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEEFVTL 346
Query: 371 RAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGL 430
+AI L N DS + + V+ L++ ++ +L+ Y ++ E P R K+L+ LP LR
Sbjct: 347 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 406
Query: 431 KCLEHLFFFKLIGDTPIDTFLMEMLEA 457
K ++H + KL G P+ +EMLEA
Sbjct: 407 KAVQHFYNIKLEGKVPMHKLFLEMLEA 433
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 219 bits (559), Expect = 3e-57
Identities = 145/447 (32%), Positives = 229/447 (51%), Gaps = 40/447 (8%)
Query: 20 TSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSV 79
T P+ S+ H S G GS S ST++ NG+ P P+
Sbjct: 18 TEPSSPASLTDSVNHHSPG---GSSDASGSYSSTMNGHQNGLDSP------PL------Y 62
Query: 80 PTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICG 139
P+ P LG GS + + SS+ P +L S K +C +CG
Sbjct: 63 PSAPILG---GSGPVRKLYDDCSSTIVEDPQTKCEYMLN----------SMPKRLCLVCG 109
Query: 140 DRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMG 199
D +SG HYGV SCE CK FFKRT++ ++ Y+C +C I KR+R CQ CR+ KCL +G
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 200 MKREAVQEERQRG---KDRNENEVESTSSANEDM------PVERILEAELAVEPKTETYV 250
M +E V+ +R RG K + + E++ N + P +I+ L EP+ + Y
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE-KIYA 228
Query: 251 EANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLI 310
+ + P S +T +C AD++L ++ WAK IP FS L L DQ+ LL++ W E+LI
Sbjct: 229 MPDPTV-PDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILI 287
Query: 311 ASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCL 370
+RS++ +D ++ A + + + AG+ + + +L +LV K + M+++K E L
Sbjct: 288 LGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEEFVTL 346
Query: 371 RAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGL 430
+AI L N DS + + V+ L++ ++ +L+ Y ++ E P R K+L+ LP LR
Sbjct: 347 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 406
Query: 431 KCLEHLFFFKLIGDTPIDTFLMEMLEA 457
K ++H + KL G P+ +EMLEA
Sbjct: 407 KAVQHFYNIKLEGKVPMHKLFLEMLEA 433
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 219 bits (559), Expect = 3e-57
Identities = 145/447 (32%), Positives = 229/447 (51%), Gaps = 40/447 (8%)
Query: 20 TSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSV 79
T P+ S+ H S G GS S ST++ NG+ P P+
Sbjct: 41 TEPSSPASLTDSVNHHSPG---GSSDASGSYSSTMNGHQNGLDSP------PL------Y 85
Query: 80 PTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICG 139
P+ P LG GS + + SS+ P +L S K +C +CG
Sbjct: 86 PSAPILG---GSGPVRKLYDDCSSTIVEDPQTKCEYMLN----------SMPKRLCLVCG 132
Query: 140 DRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMG 199
D +SG HYGV SCE CK FFKRT++ ++ Y+C +C I KR+R CQ CR+ KCL +G
Sbjct: 133 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 192
Query: 200 MKREAVQEERQRG---KDRNENEVESTSSANEDM------PVERILEAELAVEPKTETYV 250
M +E V+ +R RG K + + E++ N + P +I+ L EP+ + Y
Sbjct: 193 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE-KIYA 251
Query: 251 EANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLI 310
+ + P S +T +C AD++L ++ WAK IP FS L L DQ+ LL++ W E+LI
Sbjct: 252 MPDPTV-PDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILI 310
Query: 311 ASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCL 370
+RS++ +D ++ A + + + AG+ + + +L +LV K + M+++K E L
Sbjct: 311 LGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEEFVTL 369
Query: 371 RAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGL 430
+AI L N DS + + V+ L++ ++ +L+ Y ++ E P R K+L+ LP LR
Sbjct: 370 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 429
Query: 431 KCLEHLFFFKLIGDTPIDTFLMEMLEA 457
K ++H + KL G P+ +EMLEA
Sbjct: 430 KAVQHFYNIKLEGKVPMHKLFLEMLEA 456
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 219 bits (559), Expect = 3e-57
Identities = 145/447 (32%), Positives = 229/447 (51%), Gaps = 40/447 (8%)
Query: 20 TSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSV 79
T P+ S+ H S G GS S ST++ NG+ P P+
Sbjct: 18 TEPSSPASLTDSVNHHSPG---GSSDASGSYSSTMNGHQNGLDSP------PL------Y 62
Query: 80 PTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICG 139
P+ P LG GS + + SS+ P +L S K +C +CG
Sbjct: 63 PSAPILG---GSGPVRKLYDDCSSTIVEDPQTKCEYMLN----------SMPKRLCLVCG 109
Query: 140 DRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMG 199
D +SG HYGV SCE CK FFKRT++ ++ Y+C +C I KR+R CQ CR+ KCL +G
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 200 MKREAVQEERQRG---KDRNENEVESTSSANEDM------PVERILEAELAVEPKTETYV 250
M +E V+ +R RG K + + E++ N + P +I+ L EP+ + Y
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE-KIYA 228
Query: 251 EANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLI 310
+ + P S +T +C AD++L ++ WAK IP FS L L DQ+ LL++ W E+LI
Sbjct: 229 MPDPTV-PDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILI 287
Query: 311 ASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCL 370
+RS++ +D ++ A + + + AG+ + + +L +LV K + M+++K E L
Sbjct: 288 LGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAIL-QLVKKYKSMKLEKEEFVTL 346
Query: 371 RAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGL 430
+AI L N DS + + V+ L++ ++ +L+ Y ++ E P R K+L+ LP LR
Sbjct: 347 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 406
Query: 431 KCLEHLFFFKLIGDTPIDTFLMEMLEA 457
K ++H + KL G P+ +EMLEA
Sbjct: 407 KAVQHFYNIKLEGKVPMHKLFLEMLEA 433
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 215 bits (547), Expect = 8e-56
Identities = 130/383 (33%), Positives = 196/383 (51%), Gaps = 52/383 (13%)
Query: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD--CLID 180
P+G+ + C +CGDRSSGKHYGVY+C+GC GFFKR++R++ TY C+ C +D
Sbjct: 4 PAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVD 63
Query: 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQ--------------RG-KDRNENEVESTSS 225
K RN+C+ CR +KCL + M ++AVQ ER RG K+ N S+
Sbjct: 64 KTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSA 123
Query: 226 ANEDMPVERILEAELAVEP--------KTETYVEANMGLNPSSPNDP------------- 264
A +P A +EP T + + L +P P
Sbjct: 124 A---LPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV 180
Query: 265 -VTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDG 323
++C++A + LF ++WAK +P FS L L DQ++LL W EL + + +I V
Sbjct: 181 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 240
Query: 324 ILLATGLHVHRNSAHSAGVGAIFDRV--LTELVSKMRDMQMDKTELGCLRAIVLFNP--- 378
LLA ++ ++ S + I + L E+V++ R +++D TE CL+ IV F
Sbjct: 241 TLLAVS-GMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPT 299
Query: 379 ----DSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLE 434
+ + N A + AL+++ +L +Y +YP QP RF KLLL LPALRSI +E
Sbjct: 300 HSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIE 359
Query: 435 HLFFFKLIGDTPIDTFLMEMLEA 457
+FF K IG+ PI L +M ++
Sbjct: 360 EVFFKKTIGNVPITRLLSDMYKS 382
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 214 bits (546), Expect = 1e-55
Identities = 118/335 (35%), Positives = 189/335 (56%), Gaps = 12/335 (3%)
Query: 132 KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCR 191
K +C +CGD +SG HYGV SCE CK FFKRT++ ++ Y+C +C I KR+R CQ CR
Sbjct: 100 KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACR 159
Query: 192 YQKCLAMGMKREAVQEERQR-GKDRNENEVESTSSANEDM--------PVERILEAELAV 242
+ KCL +GM +E V+ +R R G+ + + ++S SS + P+ +I+ L
Sbjct: 160 FMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVA 219
Query: 243 EPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLR 302
EP + Y G+ P +T +C AD++L ++ WAK IP FS L L DQ+ LL+
Sbjct: 220 EP-DKLYAMPPPGM-PEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQ 277
Query: 303 AGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQM 362
+ W E+LI +RS+ D ++ A + + AG+ ++ R + +LV + + +++
Sbjct: 278 SAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELY-RAILQLVRRYKKLKV 336
Query: 363 DKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRL 422
+K E L+A+ L N DS + + V+ L++ ++ +L+ Y + E+P R KLLL L
Sbjct: 337 EKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTL 396
Query: 423 PALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 457
P LR K ++H + KL G P+ +EMLEA
Sbjct: 397 PLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEA 431
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 214 bits (546), Expect = 1e-55
Identities = 141/442 (31%), Positives = 210/442 (47%), Gaps = 43/442 (9%)
Query: 26 GSMAAPSLHPSLGPGIGSPGQLHS--PISTLSSPINGMGPPFSVISSPMGPHSMSVPTTP 83
G++ S +P G PG L P LS G+G P P S+SV T
Sbjct: 12 GALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQP----DLPKEMASLSVETQS 67
Query: 84 TLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSS 143
T SSE++ VP+ PS C +C D+SS
Sbjct: 68 T------------------SSEEM-----------VPSSPSPPPPPRVYKPCFVCNDKSS 98
Query: 144 GKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKRE 203
G HYGV SCEGCKGFF+R+++K++ YTC +K+C+I+K RNRCQYCR QKC +GM +E
Sbjct: 99 GYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE 158
Query: 204 AVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPND 263
AV+ +R + K + E S E I + A + + + SS +
Sbjct: 159 AVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADH 218
Query: 264 PV-------TNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHR 316
V + A K + +VE+AKR+P F+ L + DQ+ LL+A ++L+ R
Sbjct: 219 RVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTR 278
Query: 317 SIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLF 376
+D + + GL ++R H+AG G + D V ++ ++MD TE G L AI L
Sbjct: 279 YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-FAGQLLPLEMDDTETGLLSAICLI 337
Query: 377 NPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHL 436
D L P +V+ L+E + +L Y + + P QP F ++L+++ LR I K E
Sbjct: 338 CGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERA 397
Query: 437 FFFKLIGDTPIDTFLMEMLEAP 458
K+ P+ + EMLE P
Sbjct: 398 ITLKMEIPGPMPPLIREMLENP 419
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 208 bits (530), Expect = 7e-54
Identities = 119/347 (34%), Positives = 181/347 (52%), Gaps = 8/347 (2%)
Query: 119 VPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCL 178
VP+ PS C +C D+SSG HYGV SCEGCKGFF+R+++K++ YTC +K+C+
Sbjct: 63 VPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCI 122
Query: 179 IDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEA 238
I+K RNRCQYCR QKC +GM +EAV+ +R + K + E S E I +
Sbjct: 123 INKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKV 182
Query: 239 ELAVEPKTETYVEANMGLNPSSPNDPV-------TNICQAADKQLFTLVEWAKRIPHFSE 291
A + + + SS + V + A K + +VE+AKR+P F+
Sbjct: 183 SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTG 242
Query: 292 LPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLT 351
L + DQ+ LL+A ++L+ R +D + + GL ++R H+AG G + D V
Sbjct: 243 LSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA 302
Query: 352 ELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQ 411
++ ++MD TE G L AI L D L P +V+ L+E + +L Y + + P Q
Sbjct: 303 -FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQ 361
Query: 412 PGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 458
P F ++L+++ LR I K E K+ P+ + EMLE P
Sbjct: 362 PYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENP 408
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 205 bits (521), Expect = 8e-53
Identities = 122/349 (34%), Positives = 191/349 (54%), Gaps = 16/349 (4%)
Query: 119 VPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCL 178
VP+ PS C +C D+SSG HYGV +CEGCKGFF+R+++K++ YTC +K+C+
Sbjct: 65 VPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCV 124
Query: 179 IDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSS----ANEDMPVER 234
I+K RNRCQYCR QKC +GM +E+V+ +R + K + ++ E T S A D E+
Sbjct: 125 INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK-KKKETSKQECTESYEMTAELDDLTEK 183
Query: 235 ILEAELAVEPKTETYVEANMGLNPSSPNDPV-------TNICQAADKQLFTLVEWAKRIP 287
I +A P + + SS + V + A K + +VE+AKR+P
Sbjct: 184 IRKAHQETFP---SLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP 240
Query: 288 HFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD 347
F+ L + DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D
Sbjct: 241 GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 300
Query: 348 RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHK 407
V T +++ ++MD TE G L AI L D + L P +V+ L+E + +L+ Y + +
Sbjct: 301 LVFT-FANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKR 359
Query: 408 YPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
P +P F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 360 RPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 408
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 204 bits (520), Expect = 1e-52
Identities = 131/401 (32%), Positives = 204/401 (50%), Gaps = 21/401 (5%)
Query: 63 PPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAH 122
PP SP G + P G+ST SP + SSSE+I VP+
Sbjct: 29 PPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQS--SSSEEI-----------VPSP 75
Query: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
PS C +C D+SSG HYGV +CEGCKGFF+R+++K++ YTC +K+C+I+K
Sbjct: 76 PSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKV 135
Query: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGK---DRNENEVESTSSANEDMPVERILEAE 239
RNRCQYCR QKC +GM +E+V+ +R + K + E T + +E++ +A
Sbjct: 136 TRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAH 195
Query: 240 LAVEP---KTETYVEANMGLNPSSPN-DPVTNICQAADKQLFTLVEWAKRIPHFSELPLD 295
P + Y N S + D + + K + VE+AK++P F+ L +
Sbjct: 196 QETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIA 255
Query: 296 DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS 355
DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D V +
Sbjct: 256 DQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-FAN 314
Query: 356 KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF 415
++ ++MD E G L AI L D + L P V+ L+E + +L+ Y + + P +P F
Sbjct: 315 QLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMF 374
Query: 416 AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 375 PKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 204 bits (520), Expect = 1e-52
Identities = 131/401 (32%), Positives = 204/401 (50%), Gaps = 21/401 (5%)
Query: 63 PPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAH 122
PP SP G + P G+ST SP + SSSE+I VP+
Sbjct: 29 PPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQS--SSSEEI-----------VPSP 75
Query: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
PS C +C D+SSG HYGV +CEGCKGFF+R+++K++ YTC +K+C+I+K
Sbjct: 76 PSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKV 135
Query: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGK---DRNENEVESTSSANEDMPVERILEAE 239
RNRCQYCR QKC +GM +E+V+ +R + K + E T + +E++ +A
Sbjct: 136 TRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAH 195
Query: 240 LAVEP---KTETYVEANMGLNPSSPN-DPVTNICQAADKQLFTLVEWAKRIPHFSELPLD 295
P + Y N S + D + + K + VE+AK++P F+ L +
Sbjct: 196 QETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIA 255
Query: 296 DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS 355
DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D V +
Sbjct: 256 DQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-FAN 314
Query: 356 KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF 415
++ ++MD E G L AI L D + L P V+ L+E + +L+ Y + + P +P F
Sbjct: 315 QLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMF 374
Query: 416 AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 375 PKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 201 bits (511), Expect = 1e-51
Identities = 131/406 (32%), Positives = 202/406 (49%), Gaps = 46/406 (11%)
Query: 95 SSPMNPVSSSE-DIKPPLGL-----------------NGVLKVPAHPSGN---MASFTKH 133
+SP +P SSE + +PP+ L +G P G ++S K
Sbjct: 18 ASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKR 77
Query: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQ 193
+C +CGD +SG HYGV SCE CK FFKRT++ + Y+C + +C I KR+R CQ CR+
Sbjct: 78 LCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFT 137
Query: 194 KCLAMGMKREAVQEERQRG---KDRNENEVE---------------STSSANEDMPVERI 235
KCL +GM +E V+ +R RG K + EV+ + PV +
Sbjct: 138 KCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNAL 197
Query: 236 LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD 295
+ L VEP+ + G P V +C D+++ + WAK IP FS L L
Sbjct: 198 VSHLLVVEPEKLYAMPDPAG--PDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLS 255
Query: 296 DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS 355
DQ+ +L++ W E+L+ + RS+ ++D + A L + A +AG+G + L +LV
Sbjct: 256 DQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGEL-GAALLQLVR 314
Query: 356 KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPG-- 413
+++ +++++ E L+A+ L N DS + + VE LRE ++ +L Y + G
Sbjct: 315 RLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAE 374
Query: 414 --RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEA 457
R +LLL LP LR K L H + KL G P+ +EMLEA
Sbjct: 375 RRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA 420
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 197 bits (502), Expect = 1e-50
Identities = 128/391 (32%), Positives = 201/391 (51%), Gaps = 25/391 (6%)
Query: 73 GPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTK 132
GP+S + TP S S + S SSSE+I VP+ PS
Sbjct: 38 GPYSTPL-RTPLWNGSNHSIETQS-----SSSEEI-----------VPSPPSPPPLPRIY 80
Query: 133 HICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRY 192
C +C D+SSG HYGV +CEGCKGFF+R+++K++ YTC +K+C+I+K RNRCQYCR
Sbjct: 81 KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRL 140
Query: 193 QKCLAMGMKREAVQEERQRGK---DRNENEVESTSSANEDMPVERILEAELAVEP---KT 246
QKC +GM +E+V+ +R + K + E T + +E++ +A P +
Sbjct: 141 QKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQL 200
Query: 247 ETYVEANMGLNPSSPN-DPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGW 305
Y N S + D + + K + VE+AK++P F+ L + DQ+ LL+A
Sbjct: 201 GKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAAC 260
Query: 306 NELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKT 365
++LI R +D + + GL ++R H+AG G + D V +++ ++MD
Sbjct: 261 LDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-FANQLLPLEMDDA 319
Query: 366 ELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPAL 425
E G L AI L D + L P V+ L+E + +L+ Y + + P +P F K+L+++ L
Sbjct: 320 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 379
Query: 426 RSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
RSI K E + K+ + + EMLE
Sbjct: 380 RSISAKGAERVITLKMEIPGSMPPLIQEMLE 410
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 188 bits (477), Expect = 1e-47
Identities = 129/418 (30%), Positives = 212/418 (50%), Gaps = 26/418 (6%)
Query: 46 QLHSPISTLSSPINGMGPPFSVISSPM----GPHSMSVPTTPTLGFSTGSPQLSSPMNPV 101
Q +P+S LS PP + +SS GP + + P Q + NP+
Sbjct: 165 QRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPI 224
Query: 102 SSSEDIKPP---LGLNGVL---KVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGC 155
+ P +G L +VP+ PS S + +CA+CGD ++ +HYGV +CEGC
Sbjct: 225 RKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPS-NEGLCAVCGDNAACQHYGVRTCEGC 283
Query: 156 KGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRG-KD 214
KGFFKRTV+K+ Y C NK+C +DKR+RNRCQYCR+QKCLA+GM +E V+ + +G +
Sbjct: 284 KGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRG 343
Query: 215 RNENEVESTSSANEDMP----VERILEAELAVEPKTETYVEANMGLNP--SSPNDPVTNI 268
R ++ +S + P + ++ A + P + + NP D +I
Sbjct: 344 RLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHI 403
Query: 269 CQAAD---KQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGIL 325
Q D + + WA++IP F++LP DQ +L + + EL + ++RS V+ ++
Sbjct: 404 QQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLI 463
Query: 326 LATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSN 385
G+ +HR G G D ++ E S +++M +D + C+ A+ + + GL
Sbjct: 464 FCNGVVLHRLQC-VRGFGEWIDSIV-EFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKE 520
Query: 386 PAEVEALREKVYASLEAYCKHKYP--EQPGRFAKLLLRLPALRSIGLKCLEHLFFFKL 441
P VE L+ K+ L+ + +P +KLL +LP LR++ + L+ +F+ KL
Sbjct: 521 PKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKL 578
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 187 bits (476), Expect = 1e-47
Identities = 145/467 (31%), Positives = 225/467 (48%), Gaps = 36/467 (7%)
Query: 21 SPTGRGSMAAPSLHP-SLGPGIGS-----PGQLHSPISTLSSPI-NGMGPP----FSVIS 69
SP S + PS P L P GS P Q + + + + GPP F S
Sbjct: 134 SPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFS 193
Query: 70 SPMGPHSMSVPTTPTLGFST------GSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHP 123
P GP S S+ +P F + G + S P L +G+L P
Sbjct: 194 PPTGP-SPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTS 252
Query: 124 S---GNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID 180
+ ++ CA+CGD +S +HYGV +CEGCKGFFKRTV+K+ Y C NKDC +D
Sbjct: 253 TKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVD 312
Query: 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRG-KDRNENEVESTSSANEDMPVERILEAE 239
KR+RNRCQ+CR+QKCLA+GM +E V+ + +G + R ++ + A+ + ++ A
Sbjct: 313 KRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAH 372
Query: 240 LAVEPKTE--TYVEANMGLNPSSPNDPVTNICQAAD---KQLFTLVEWAKRIPHFSELPL 294
L P T Y + + P + ++ Q D L + +WA++IP F+EL
Sbjct: 373 LDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSP 432
Query: 295 DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELV 354
DQ +LL + + EL I ++RS + ++ +GL +HR + G G D +L
Sbjct: 433 ADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILA-FS 490
Query: 355 SKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAY--CKHKYPEQP 412
+ + +D CL A+VL D GL P VE L+ ++ + L+ + P+
Sbjct: 491 RSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPA 549
Query: 413 GRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP----IDTFLMEML 455
++LL +LP LR++ + L+ +F+ KL P ID M+ L
Sbjct: 550 SCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 187 bits (476), Expect = 1e-47
Identities = 145/467 (31%), Positives = 225/467 (48%), Gaps = 36/467 (7%)
Query: 21 SPTGRGSMAAPSLHP-SLGPGIGS-----PGQLHSPISTLSSPI-NGMGPP----FSVIS 69
SP S + PS P L P GS P Q + + + + GPP F S
Sbjct: 134 SPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFS 193
Query: 70 SPMGPHSMSVPTTPTLGFST------GSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHP 123
P GP S S+ +P F + G + S P L +G+L P
Sbjct: 194 PPTGP-SPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTS 252
Query: 124 S---GNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID 180
+ ++ CA+CGD +S +HYGV +CEGCKGFFKRTV+K+ Y C NKDC +D
Sbjct: 253 TKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVD 312
Query: 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRG-KDRNENEVESTSSANEDMPVERILEAE 239
KR+RNRCQ+CR+QKCLA+GM +E V+ + +G + R ++ + A+ + ++ A
Sbjct: 313 KRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAH 372
Query: 240 LAVEPKTE--TYVEANMGLNPSSPNDPVTNICQAAD---KQLFTLVEWAKRIPHFSELPL 294
L P T Y + + P + ++ Q D L + +WA++IP F+EL
Sbjct: 373 LDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSP 432
Query: 295 DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELV 354
DQ +LL + + EL I ++RS + ++ +GL +HR + G G D +L
Sbjct: 433 ADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILA-FS 490
Query: 355 SKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAY--CKHKYPEQP 412
+ + +D CL A+VL D GL P VE L+ ++ + L+ + P+
Sbjct: 491 RSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPA 549
Query: 413 GRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP----IDTFLMEML 455
++LL +LP LR++ + L+ +F+ KL P ID M+ L
Sbjct: 550 SCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,564,047
Number of Sequences: 37866
Number of extensions: 1024635
Number of successful extensions: 5207
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 210
Number of HSP's that attempted gapping in prelim test: 4424
Number of HSP's gapped (non-prelim): 813
length of query: 462
length of database: 18,247,518
effective HSP length: 106
effective length of query: 356
effective length of database: 14,233,722
effective search space: 5067205032
effective search space used: 5067205032
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.