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Search of human proteins with 4506295
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506295 protein tyrosine phosphatase, non-receptor type 4
[Homo sapiens]
(926 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 1904 0.0
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 940 0.0
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 907 0.0
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 783 0.0
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 749 0.0
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i... 622 e-178
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i... 589 e-168
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 322 1e-87
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 322 1e-87
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 310 3e-84
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 310 3e-84
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 310 3e-84
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 308 1e-83
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 299 7e-81
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 299 7e-81
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 283 5e-76
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 277 4e-74
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 269 1e-71
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 262 1e-69
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 261 3e-69
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 261 3e-69
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 257 3e-68
gi|34916000 FERM domain containing 7 [Homo sapiens] 236 7e-62
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 223 6e-58
gi|117500790 FERM domain containing 3 [Homo sapiens] 221 3e-57
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 203 7e-52
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 186 7e-47
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 186 7e-47
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 186 7e-47
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 186 7e-47
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 1904 bits (4931), Expect = 0.0
Identities = 926/926 (100%), Positives = 926/926 (100%)
Query: 1 MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK 60
MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK
Sbjct: 1 MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK 60
Query: 61 HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE 120
HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE
Sbjct: 61 HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE 120
Query: 121 YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ 180
YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ
Sbjct: 121 YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ 180
Query: 181 PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG 240
PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG
Sbjct: 181 PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG 240
Query: 241 ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA 300
ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA
Sbjct: 241 ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA 300
Query: 301 CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPS 360
CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPS
Sbjct: 301 CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPS 360
Query: 361 KPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV 420
KPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV
Sbjct: 361 KPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV 420
Query: 421 DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHY 480
DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHY
Sbjct: 421 DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHY 480
Query: 481 SHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKM 540
SHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKM
Sbjct: 481 SHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKM 540
Query: 541 PVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLL 600
PVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLL
Sbjct: 541 PVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLL 600
Query: 601 VRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFD 660
VRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFD
Sbjct: 601 VRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFD 660
Query: 661 QLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSII 720
QLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSII
Sbjct: 661 QLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSII 720
Query: 721 NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQ 780
NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQ
Sbjct: 721 NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQ 780
Query: 781 VTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK 840
VTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK
Sbjct: 781 VTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK 840
Query: 841 RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQ 900
RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQ
Sbjct: 841 RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQ 900
Query: 901 YRFVCEAILKVYEEGFVKPLTTSTNK 926
YRFVCEAILKVYEEGFVKPLTTSTNK
Sbjct: 901 YRFVCEAILKVYEEGFVKPLTTSTNK 926
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 940 bits (2430), Expect = 0.0
Identities = 489/951 (51%), Positives = 638/951 (67%), Gaps = 66/951 (6%)
Query: 1 MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK 60
MTSR R GR N+R SEL +++ +EV+C+I LD VQ FKV K D GQVLLD+V
Sbjct: 1 MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN 60
Query: 61 HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE 120
HL +TE++YFGLQ DDS D+PRWL+ +K IRKQLK G P +L+FRV+FF+ DPN LQ+E
Sbjct: 61 HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE 120
Query: 121 YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ 180
TR+ YFLQ+K DI GRL CP N+A +LAS+AVQS GDY+ S + GYLSD FIP+Q
Sbjct: 121 QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ 180
Query: 181 PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG 240
+DF ++ LH+QH GL +EAE Y+N ARTL+ YGVE H RD N ++MIG+ S G
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240
Query: 241 ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA 300
+ +Y+ + + +PW+ I+KISFK K+FFI R++ ESRE ++ FNM+NYR+CKNLWK+
Sbjct: 241 VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 300
Query: 301 CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSV--QYGKEKANKDRVFARS 358
CVEHHTFF+ + LP +KN + Y+T+GS R +SV QY K+
Sbjct: 301 CVEHHTFFQAKKLLPQEKNVLSQYWTMGS------RNTKKSVNNQYCKKVIGG------- 347
Query: 359 PSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGH 418
M W R S+S + LET+SLPSRSPP TPN R+ E + R SS +
Sbjct: 348 ---------MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADN 398
Query: 419 LVDHMVH-TSPSEVFV----------------NQRSP------SSTQANSIVLESSPSQE 455
L + M + T +VF RSP + A S + + S S
Sbjct: 399 LANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSV 458
Query: 456 TPGDGKPPALPP---KQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPH 512
+P P + P Q + ++++ S +D + + D NG
Sbjct: 459 SPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKND----------NG---D 505
Query: 513 DNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGR 572
LVLIR+ PDE+G+FGFN+KGG DQKMP++VSR+ P +PAD C+P+LNEGDQ+VLINGR
Sbjct: 506 SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGR 565
Query: 573 DIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSV 632
DI+EHTHDQVV+FIKAS E HS EL L++R AV + K E+E + Q PE A
Sbjct: 566 DISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELN-QLFPE-AIFPMC 623
Query: 633 HQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYD 692
+ +L SM QL +GL +GTVL QF+QLYRKKPG+ ++ AKLPQN+ KNRY+D+ PYD
Sbjct: 624 PEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYD 683
Query: 693 ATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVML 752
TRV+L+GNEDYINA+Y+NMEIP+++++N+YIA QGPLPHTC FWQ+ W+Q S++VML
Sbjct: 684 TTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML 743
Query: 753 TTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQ 812
TT ERGR KCHQYWP+P ++G + + C SE+ AY+ R+M + N + E +T
Sbjct: 744 TTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTH 803
Query: 813 IQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLI 872
+QY+AWPDHGVPDDSSDFL+FV +VR+ R EPV+VHCSAGIGRTGVL+TMETAMCL
Sbjct: 804 LQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVHCSAGIGRTGVLVTMETAMCLT 862
Query: 873 ECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTS 923
E N P+YPLDIVR MRDQRAMM+QT SQY+FVCEAIL+VYEEG V+ L S
Sbjct: 863 ERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 913
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 907 bits (2343), Expect = 0.0
Identities = 464/923 (50%), Positives = 621/923 (67%), Gaps = 55/923 (5%)
Query: 1 MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK 60
MTSR R GR N+R SEL +++ +EV+C+I LD VQ FKV K D GQVLLD+V
Sbjct: 1 MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN 60
Query: 61 HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE 120
HL +TE++YFGLQ DDS D+PRWL+ +K IRKQLK G P +L+FRV+FF+ DPN LQ+E
Sbjct: 61 HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQE 120
Query: 121 YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ 180
TR+ YFLQ+K DI GRL CP N+A +LAS+AVQS GDY+ S + GYLSD FIP+Q
Sbjct: 121 QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ 180
Query: 181 PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG 240
+DF ++ LH+QH GL +EAE Y+N ARTL+ YGVE H RD N ++MIG+ S G
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240
Query: 241 ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA 300
+ +Y+ + + +PW+ I+KISFK K+FFI R++ ESRE ++ FNM+NYR+CKNLWK+
Sbjct: 241 VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 300
Query: 301 CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPS 360
CVEHHTFF+ + LP +KN + Y+T+GS+ K+++ + R R P
Sbjct: 301 CVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNT-------------KKRSPRLRHEIRKP- 346
Query: 361 KPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV 420
R+S +D+ + + + ++ S Q+ +
Sbjct: 347 --------------RHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQ 392
Query: 421 DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHY 480
+ + +P++ ++ Q+S SS SPS PG P + Q + ++++
Sbjct: 393 ESLSENNPAQSYLTQKSSSSV---------SPSSNAPGSCSPDGVD--QQLLDDFHRVTK 441
Query: 481 SHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKM 540
S +D + + D NG LVLIR+ PDE+G+FGFN+KGG DQKM
Sbjct: 442 GGSTEDASQYYCDKND----------NGD---SYLVLIRITPDEDGKFGFNLKGGVDQKM 488
Query: 541 PVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLL 600
P++VSR+ P +PAD C+P+LNEGDQ+VLINGRDI+EHTHDQVV+FIKAS E HS EL L+
Sbjct: 489 PLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALV 548
Query: 601 VRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFD 660
+R AV + K E+E + Q PE A + +L SM QL +GL +GTVL QF+
Sbjct: 549 IRRRAVRSFADFKSEDELN-QLFPE-AIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFE 606
Query: 661 QLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSII 720
QLYRKKPG+ ++ AKLPQN+ KNRY+D+ PYD TRV+L+GNEDYINA+Y+NMEIP+++++
Sbjct: 607 QLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLV 666
Query: 721 NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQ 780
N+YIA QGPLPHTC FWQ+ W+Q S++VMLTT ERGR KCHQYWP+P ++G +
Sbjct: 667 NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFH 726
Query: 781 VTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK 840
+ C SE+ AY+ R+M + N + E +T +QY+AWPDHGVPDDSSDFL+FV +VR+
Sbjct: 727 IQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSL 786
Query: 841 RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQ 900
R EPV+VHCSAGIGRTGVL+TMETAMCL E N P+YPLDIVR MRDQRAMM+QT SQ
Sbjct: 787 RV-DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQ 845
Query: 901 YRFVCEAILKVYEEGFVKPLTTS 923
Y+FVCEAIL+VYEEG V+ L S
Sbjct: 846 YKFVCEAILRVYEEGLVQMLDPS 868
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 783 bits (2022), Expect = 0.0
Identities = 414/820 (50%), Positives = 541/820 (65%), Gaps = 68/820 (8%)
Query: 133 DILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLH 192
DI GRL CP N+A +LAS+AVQS GDY+ S + GYLSD FIP+Q +DF ++ LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 193 QQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT 252
+QH GL +EAE Y+N ARTL+ YGVE H RD N ++MIG+ S G+ +Y+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 253 FPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDR 312
+PW+ I+KISFK K+FFI R++ ESRE ++ FNM+NYR+CKNLWK+CVEHHTFF+ +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 313 PLPPQKNFFAHYFTLGSKFRYCGRTEVQSV--QYGKEKANKDRVFARSPSKPLARKLMDW 370
LP +KN + Y+T+GS R +SV QY K+ M W
Sbjct: 182 LLPQEKNVLSQYWTMGS------RNTKKSVNNQYCKKVIGG----------------MVW 219
Query: 371 EVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHT---- 426
R S+S + LET+SLPSRSPP TPN R+ E + R SS +L + M +
Sbjct: 220 NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETE 279
Query: 427 --------------SPSEVFVNQRSP------SSTQANSIVLESSPSQETPGDGKPPALP 466
S SEV N RSP + A S + + S S +P P +
Sbjct: 280 DVFYTYKGSLAPQDSDSEVSQN-RSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCS 338
Query: 467 PK---QSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPD 523
P Q + ++++ S +D + + D NG LVLIR+ PD
Sbjct: 339 PDGVDQQLLDDFHRVTKGGSTEDASQYYCDKND----------NGD---SYLVLIRITPD 385
Query: 524 ENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVV 583
E+G+FGFN+KGG DQKMP++VSR+ P +PAD C+P+LNEGDQ+VLINGRDI+EHTHDQVV
Sbjct: 386 EDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVV 445
Query: 584 LFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESM 643
+FIKAS E HS EL L++R AV + K E+E + Q PE A + +L SM
Sbjct: 446 MFIKASRESHSRELALVIRRRAVRSFADFKSEDELN-QLFPE-AIFPMCPEGGDTLEGSM 503
Query: 644 IQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNED 703
QL +GL +GTVL QF+QLYRKKPG+ ++ AKLPQN+ KNRY+D+ PYD TRV+L+GNED
Sbjct: 504 AQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNED 563
Query: 704 YINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKC 763
YINA+Y+NMEIP+++++N+YIA QGPLPHTC FWQ+ W+Q S++VMLTT ERGR KC
Sbjct: 564 YINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKC 623
Query: 764 HQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGV 823
HQYWP+P ++G + + C SE+ AY+ R+M + N + E +T +QY+AWPDHGV
Sbjct: 624 HQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGV 683
Query: 824 PDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDI 883
PDDSSDFL+FV +VR+ R EPV+VHCSAGIGRTGVL+TMETAMCL E N P+YPLDI
Sbjct: 684 PDDSSDFLEFVNYVRSLRV-DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDI 742
Query: 884 VRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTS 923
VR MRDQRAMM+QT SQY+FVCEAIL+VYEEG V+ L S
Sbjct: 743 VRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 782
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 749 bits (1935), Expect = 0.0
Identities = 387/791 (48%), Positives = 523/791 (66%), Gaps = 55/791 (6%)
Query: 133 DILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLH 192
DI GRL CP N+A +LAS+AVQS GDY+ S + GYLSD FIP+Q +DF ++ LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 193 QQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT 252
+QH GL +EAE Y+N ARTL+ YGVE H RD N ++MIG+ S G+ +Y+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 253 FPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDR 312
+PW+ I+KISFK K+FFI R++ ESRE ++ FNM+NYR+CKNLWK+CVEHHTFF+ +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 313 PLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEV 372
LP +KN + Y+T+GS+ K+++ + R R P
Sbjct: 182 LLPQEKNVLSQYWTMGSRNT-------------KKRSPRLRHEIRKP------------- 215
Query: 373 VSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVF 432
R+S +D+ + + + ++ S Q+ + + + +P++ +
Sbjct: 216 --RHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSY 273
Query: 433 VNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHIN 492
+ Q+S SS SPS PG P + Q + ++++ S +D +
Sbjct: 274 LTQKSSSSV---------SPSSNAPGSCSPDGVD--QQLLDDFHRVTKGGSTEDASQYYC 322
Query: 493 ETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTP 552
+ D NG LVLIR+ PDE+G+FGFN+KGG DQKMP++VSR+ P +P
Sbjct: 323 DKND----------NGD---SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESP 369
Query: 553 ADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEE 612
AD C+P+LNEGDQ+VLINGRDI+EHTHDQVV+FIKAS E HS EL L++R AV +
Sbjct: 370 ADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADF 429
Query: 613 KLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMS 672
K E+E + Q PE A + +L SM QL +GL +GTVL QF+QLYRKKPG+ ++
Sbjct: 430 KSEDELN-QLFPE-AIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAIT 487
Query: 673 CAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPH 732
AKLPQN+ KNRY+D+ PYD TRV+L+GNEDYINA+Y+NMEIP+++++N+YIA QGPLPH
Sbjct: 488 FAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPH 547
Query: 733 TCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAY 792
TC FWQ+ W+Q S++VMLTT ERGR KCHQYWP+P ++G + + C SE+ AY
Sbjct: 548 TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAY 607
Query: 793 IFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHC 852
+ R+M + N + E +T +QY+AWPDHGVPDDSSDFL+FV +VR+ R EPV+VHC
Sbjct: 608 VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVHC 666
Query: 853 SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY 912
SAGIGRTGVL+TMETAMCL E N P+YPLDIVR MRDQRAMM+QT SQY+FVCEAIL+VY
Sbjct: 667 SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY 726
Query: 913 EEGFVKPLTTS 923
EEG V+ L S
Sbjct: 727 EEGLVQMLDPS 737
>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
isoform 5 [Homo sapiens]
Length = 626
Score = 622 bits (1605), Expect = e-178
Identities = 335/665 (50%), Positives = 433/665 (65%), Gaps = 68/665 (10%)
Query: 288 MVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSV--QYG 345
M+NYR+CKNLWK+CVEHHTFF+ + LP +KN + Y+T+GS R +SV QY
Sbjct: 1 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGS------RNTKKSVNNQYC 54
Query: 346 KEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFT 405
K+ M W R S+S + LET+SLPSRSPP TPN R+
Sbjct: 55 KKVIGG----------------MVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLR 98
Query: 406 QEGTRLRPSSVGHLVDHMVHT------------------SPSEVFVNQRSP------SST 441
E + R SS +L + M + S SEV N RSP +
Sbjct: 99 HEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQN-RSPHQESLSENN 157
Query: 442 QANSIVLESSPSQETPGDGKPPALPPK---QSKKNSWNQIHYSHSQQDLESHINETFDIP 498
A S + + S S +P P + P Q + ++++ S +D + + D
Sbjct: 158 PAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKND-- 215
Query: 499 SSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVP 558
NG LVLIR+ PDE+G+FGFN+KGG DQKMP++VSR+ P +PAD C+P
Sbjct: 216 --------NGD---SYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIP 264
Query: 559 RLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEP 618
+LNEGDQ+VLINGRDI+EHTHDQVV+FIKAS E HS EL L++R AV + K E+E
Sbjct: 265 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDEL 324
Query: 619 DFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQ 678
+ Q PE A + +L SM QL +GL +GTVL QF+QLYRKKPG+ ++ AKLPQ
Sbjct: 325 N-QLFPE-AIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQ 382
Query: 679 NISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFW 738
N+ KNRY+D+ PYD TRV+L+GNEDYINA+Y+NMEIP+++++N+YIA QGPLPHTC FW
Sbjct: 383 NLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFW 442
Query: 739 QMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMT 798
Q+ W+Q S++VMLTT ERGR KCHQYWP+P ++G + + C SE+ AY+ R+M
Sbjct: 443 QVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREML 502
Query: 799 LFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGR 858
+ N + E +T +QY+AWPDHGVPDDSSDFL+FV +VR+ R EPV+VHCSAGIGR
Sbjct: 503 VTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVHCSAGIGR 561
Query: 859 TGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVK 918
TGVL+TMETAMCL E N P+YPLDIVR MRDQRAMM+QT SQY+FVCEAIL+VYEEG V+
Sbjct: 562 TGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQ 621
Query: 919 PLTTS 923
L S
Sbjct: 622 MLDPS 626
>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
isoform 6 [Homo sapiens]
Length = 581
Score = 589 bits (1518), Expect = e-168
Identities = 308/636 (48%), Positives = 415/636 (65%), Gaps = 55/636 (8%)
Query: 288 MVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKE 347
M+NYR+CKNLWK+CVEHHTFF+ + LP +KN + Y+T+GS+ K+
Sbjct: 1 MLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNT-------------KK 47
Query: 348 KANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQE 407
++ + R R P R+S +D+ + + + ++ S Q+
Sbjct: 48 RSPRLRHEIRKP---------------RHSSADNLANEMTYITETEDVFYTYKGSLAPQD 92
Query: 408 GTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPP 467
+ + + +P++ ++ Q+S SS SPS PG P +
Sbjct: 93 SDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSV---------SPSSNAPGSCSPDGVD- 142
Query: 468 KQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGR 527
Q + ++++ S +D + + D NG LVLIR+ PDE+G+
Sbjct: 143 -QQLLDDFHRVTKGGSTEDASQYYCDKND----------NGD---SYLVLIRITPDEDGK 188
Query: 528 FGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIK 587
FGFN+KGG DQKMP++VSR+ P +PAD C+P+LNEGDQ+VLINGRDI+EHTHDQVV+FIK
Sbjct: 189 FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 248
Query: 588 ASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLA 647
AS E HS EL L++R AV + K E+E + Q PE A + +L SM QL
Sbjct: 249 ASRESHSRELALVIRRRAVRSFADFKSEDELN-QLFPE-AIFPMCPEGGDTLEGSMAQLK 306
Query: 648 EGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINA 707
+GL +GTVL QF+QLYRKKPG+ ++ AKLPQN+ KNRY+D+ PYD TRV+L+GNEDYINA
Sbjct: 307 KGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINA 366
Query: 708 NYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYW 767
+Y+NMEIP+++++N+YIA QGPLPHTC FWQ+ W+Q S++VMLTT ERGR KCHQYW
Sbjct: 367 SYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW 426
Query: 768 PEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDS 827
P+P ++G + + C SE+ AY+ R+M + N + E +T +QY+AWPDHGVPDDS
Sbjct: 427 PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDS 486
Query: 828 SDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTM 887
SDFL+FV +VR+ R EPV+VHCSAGIGRTGVL+TMETAMCL E N P+YPLDIVR M
Sbjct: 487 SDFLEFVNYVRSLRV-DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKM 545
Query: 888 RDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTS 923
RDQRAMM+QT SQY+FVCEAIL+VYEEG V+ L S
Sbjct: 546 RDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS 581
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 322 bits (824), Expect = 1e-87
Identities = 171/399 (42%), Positives = 247/399 (61%), Gaps = 11/399 (2%)
Query: 24 RQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLAD-DSTDNP 82
+++ +C + LLD + +V KH +GQVL D+V +HL+L E+DYFGL D DS N
Sbjct: 30 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN- 88
Query: 83 RWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCP 142
WLDP+K I+KQ+ R SP++ F VKF+ DP +L E+ TRY LQ++ DI+TGRLPC
Sbjct: 89 -WLDPSKEIKKQI-RSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 146
Query: 143 SNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAE 202
T ALL S+AVQ+ELGDYD E++ Y+S+ F PNQ ++ E+ I +LH+ + G++P E
Sbjct: 147 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 206
Query: 203 AEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKIS 262
AE ++L A+ L +YGV+ H+A+D +IM+GV + G+LIY++R+R+N F W KI+KIS
Sbjct: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 266
Query: 263 FKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFA 322
+K F+I++R +E E+ +GF + N+R+ K LWK C+EHHTFFRL P PP K F
Sbjct: 267 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGF-- 324
Query: 323 HYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK--PLARKLMDWEVVSRNSISD 380
+GSKFRY GRT+ Q+ Q F RS SK ++R L E S+S+
Sbjct: 325 --LVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSE 382
Query: 381 DRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHL 419
+ R G + S +EG P+ + L
Sbjct: 383 NHDAGPDGDKRDEDGESGGQRSE-AEEGEVRTPTKIKEL 420
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 322 bits (824), Expect = 1e-87
Identities = 171/399 (42%), Positives = 247/399 (61%), Gaps = 11/399 (2%)
Query: 24 RQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLAD-DSTDNP 82
+++ +C + LLD + +V KH +GQVL D+V +HL+L E+DYFGL D DS N
Sbjct: 92 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN- 150
Query: 83 RWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCP 142
WLDP+K I+KQ+ R SP++ F VKF+ DP +L E+ TRY LQ++ DI+TGRLPC
Sbjct: 151 -WLDPSKEIKKQI-RSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 208
Query: 143 SNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAE 202
T ALL S+AVQ+ELGDYD E++ Y+S+ F PNQ ++ E+ I +LH+ + G++P E
Sbjct: 209 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 268
Query: 203 AEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKIS 262
AE ++L A+ L +YGV+ H+A+D +IM+GV + G+LIY++R+R+N F W KI+KIS
Sbjct: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 328
Query: 263 FKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFA 322
+K F+I++R +E E+ +GF + N+R+ K LWK C+EHHTFFRL P PP K F
Sbjct: 329 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGF-- 386
Query: 323 HYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK--PLARKLMDWEVVSRNSISD 380
+GSKFRY GRT+ Q+ Q F RS SK ++R L E S+S+
Sbjct: 387 --LVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSE 444
Query: 381 DRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHL 419
+ R G + S +EG P+ + L
Sbjct: 445 NHDAGPDGDKRDEDGESGGQRSE-AEEGEVRTPTKIKEL 482
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 310 bits (795), Expect = 3e-84
Identities = 164/363 (45%), Positives = 232/363 (63%), Gaps = 12/363 (3%)
Query: 12 TYNVRASELARDRQHTEVV-------CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDL 64
T V+ +EL ++ +V C + LLD T + + KH +GQVL D V +HL+L
Sbjct: 194 TKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNL 253
Query: 65 TEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRY 124
E+DYFGL L +S + WLDP K I++QL R P+ F VKF+ DP++L E+ TRY
Sbjct: 254 LEKDYFGL-LFQESPEQKNWLDPAKEIKRQL-RNLPWLFTFNVKFYPPDPSQLTEDITRY 311
Query: 125 QYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDF 184
LQ++QDI +GRLPC T ALL S+ +Q+ELGDYD E+ S LS++ F P Q ++
Sbjct: 312 FLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL 371
Query: 185 EKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIY 244
E+++A+LH+ H GLSPA+A+ +L A+ L +YGV+ H+A+D +I +GV + G+LIY
Sbjct: 372 EEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY 431
Query: 245 KNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEH 304
K+R+R+N F W KI+KIS+K F+I++R E E+ +GF + N+RA K LWK CVEH
Sbjct: 432 KDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEH 491
Query: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA 364
HTF+RL P P K A + TLGSKFRY GRT+ Q+ Q F R+ SK ++
Sbjct: 492 HTFYRLVSPEQPPK---AKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS 548
Query: 365 RKL 367
R L
Sbjct: 549 RSL 551
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 310 bits (795), Expect = 3e-84
Identities = 164/363 (45%), Positives = 232/363 (63%), Gaps = 12/363 (3%)
Query: 12 TYNVRASELARDRQHTEVV-------CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDL 64
T V+ +EL ++ +V C + LLD T + + KH +GQVL D V +HL+L
Sbjct: 194 TKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNL 253
Query: 65 TEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRY 124
E+DYFGL L +S + WLDP K I++QL R P+ F VKF+ DP++L E+ TRY
Sbjct: 254 LEKDYFGL-LFQESPEQKNWLDPAKEIKRQL-RNLPWLFTFNVKFYPPDPSQLTEDITRY 311
Query: 125 QYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDF 184
LQ++QDI +GRLPC T ALL S+ +Q+ELGDYD E+ S LS++ F P Q ++
Sbjct: 312 FLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL 371
Query: 185 EKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIY 244
E+++A+LH+ H GLSPA+A+ +L A+ L +YGV+ H+A+D +I +GV + G+LIY
Sbjct: 372 EEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY 431
Query: 245 KNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEH 304
K+R+R+N F W KI+KIS+K F+I++R E E+ +GF + N+RA K LWK CVEH
Sbjct: 432 KDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEH 491
Query: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA 364
HTF+RL P P K A + TLGSKFRY GRT+ Q+ Q F R+ SK ++
Sbjct: 492 HTFYRLVSPEQPPK---AKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS 548
Query: 365 RKL 367
R L
Sbjct: 549 RSL 551
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 310 bits (795), Expect = 3e-84
Identities = 164/363 (45%), Positives = 232/363 (63%), Gaps = 12/363 (3%)
Query: 12 TYNVRASELARDRQHTEVV-------CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDL 64
T V+ +EL ++ +V C + LLD T + + KH +GQVL D V +HL+L
Sbjct: 194 TKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNL 253
Query: 65 TEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRY 124
E+DYFGL L +S + WLDP K I++QL R P+ F VKF+ DP++L E+ TRY
Sbjct: 254 LEKDYFGL-LFQESPEQKNWLDPAKEIKRQL-RNLPWLFTFNVKFYPPDPSQLTEDITRY 311
Query: 125 QYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDF 184
LQ++QDI +GRLPC T ALL S+ +Q+ELGDYD E+ S LS++ F P Q ++
Sbjct: 312 FLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL 371
Query: 185 EKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIY 244
E+++A+LH+ H GLSPA+A+ +L A+ L +YGV+ H+A+D +I +GV + G+LIY
Sbjct: 372 EEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY 431
Query: 245 KNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEH 304
K+R+R+N F W KI+KIS+K F+I++R E E+ +GF + N+RA K LWK CVEH
Sbjct: 432 KDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEH 491
Query: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA 364
HTF+RL P P K A + TLGSKFRY GRT+ Q+ Q F R+ SK ++
Sbjct: 492 HTFYRLVSPEQPPK---AKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS 548
Query: 365 RKL 367
R L
Sbjct: 549 RSL 551
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 308 bits (790), Expect = 1e-83
Identities = 163/367 (44%), Positives = 228/367 (62%), Gaps = 12/367 (3%)
Query: 31 CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKP 90
C ++LLD + V K +GQVL D V +HL+L E+DYFGL D + + WLDP K
Sbjct: 112 CKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRD-AENQKNWLDPAKE 170
Query: 91 IRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLA 150
I+KQ++ G+ + +F VKF+ DP +L E+ TRY LQ++ DI++GRLPC T ALL
Sbjct: 171 IKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLG 229
Query: 151 SFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNT 210
S+ VQSELGDYD E S Y+S++ F PN ++ E ++ +LH+ H G++PAEAE ++L
Sbjct: 230 SYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLEN 289
Query: 211 ARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFI 270
A+ L +YGV+ H+A+D EIM+GV + G+LIY++R+R+N F W K++KIS+K F+I
Sbjct: 290 AKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYI 349
Query: 271 QLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSK 330
++R E E+ +GF + N+RA K LWK CVEHHTFFRL P P K F TLGSK
Sbjct: 350 KIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKF----LTLGSK 405
Query: 331 FRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA-RKLMDWEV-----VSRNSISDDRLE 384
FRY GRT+ Q+ + F RS SK + +D EV + IS L
Sbjct: 406 FRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLI 465
Query: 385 TQSLPSR 391
T P +
Sbjct: 466 TTVTPEK 472
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 299 bits (766), Expect = 7e-81
Identities = 154/338 (45%), Positives = 218/338 (64%), Gaps = 7/338 (2%)
Query: 31 CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKP 90
C + LLD+TV V KH +GQ LL V +HL+L E+DYFGL + D++T WLD K
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKT-WLDSAKE 61
Query: 91 IRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLA 150
I+KQ+ RG P++ F VKF+ DP +L E+ TRY LQ++QDI+ GRLPC T ALL
Sbjct: 62 IKKQV-RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 151 SFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNT 210
S+ +QSELGDYD + Y+SD+ PNQ ++ E+++ +LH+ + ++PA+A+ +L
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 211 ARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFI 270
A+ L +YGV+ H A+D +I++GV S G+L+YK+++R+N FPW K++KIS+K FFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 271 QLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGS 329
++R E E+ +GF + +YRA K LWK CVEHHTFFRL P+ F A LGS
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLA----LGS 296
Query: 330 KFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKL 367
KFRY GRT+ Q+ Q F R+ SK +R L
Sbjct: 297 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSL 334
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 299 bits (766), Expect = 7e-81
Identities = 154/338 (45%), Positives = 218/338 (64%), Gaps = 7/338 (2%)
Query: 31 CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKP 90
C + LLD+TV V KH +GQ LL V +HL+L E+DYFGL + D++T WLD K
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKT-WLDSAKE 61
Query: 91 IRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLA 150
I+KQ+ RG P++ F VKF+ DP +L E+ TRY LQ++QDI+ GRLPC T ALL
Sbjct: 62 IKKQV-RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 151 SFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNT 210
S+ +QSELGDYD + Y+SD+ PNQ ++ E+++ +LH+ + ++PA+A+ +L
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 211 ARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFI 270
A+ L +YGV+ H A+D +I++GV S G+L+YK+++R+N FPW K++KIS+K FFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 271 QLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGS 329
++R E E+ +GF + +YRA K LWK CVEHHTFFRL P+ F A LGS
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLA----LGS 296
Query: 330 KFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKL 367
KFRY GRT+ Q+ Q F R+ SK +R L
Sbjct: 297 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSL 334
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 283 bits (724), Expect = 5e-76
Identities = 180/489 (36%), Positives = 262/489 (53%), Gaps = 40/489 (8%)
Query: 25 QHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRW 84
Q + + LLDNT++ F + GQVLL V+K L+L E DYFG++ ++ W
Sbjct: 40 QEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEF-QNTQSYWIW 98
Query: 85 LDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSN 144
L+P KPI +Q++R L VKFF DP +LQEEYTRY + LQ+K+D+L RL C
Sbjct: 99 LEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADT 158
Query: 145 TAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAE 204
TAALL S +QSE+GDYD++ + +L ++P Q EK I + HQ+H+G +PAE++
Sbjct: 159 TAALLTSHLLQSEIGDYDETLDRE-HLKVNEYLPGQQHCLEK-ILEFHQKHVGQTPAESD 216
Query: 205 FNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFK 264
F L AR LE+YG+ FH A D+ +I + V G+L+++ ++NTF W K+ K+SFK
Sbjct: 217 FQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK 276
Query: 265 CKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFR-LDRPLPPQKNFFAH 323
K+F I+L E+H + L F + + CKN WK CVE+HTFFR LD+P P K A
Sbjct: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAK---AV 333
Query: 324 YFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRL 383
+F+ GS FRY GRT+ Q V Y K+ K + R SK + S+ R
Sbjct: 334 FFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSK------------THTSV---RA 378
Query: 384 ETQSLPSRS--------PPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVH-TSPSEVFVN 434
T LP +S P +P+ N+ ++ + L PS + D T P +V
Sbjct: 379 LTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYV- 437
Query: 435 QRSPSSTQANSIVL--ESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHIN 492
+SP++ + + V +PS + G PPAL P Q S + L ++
Sbjct: 438 -KSPAAERRSGAVAGGPDTPSAQPLG---PPALQPGPGLSTKSPQPSPSSRKSPLS--LS 491
Query: 493 ETFDIPSSP 501
F +P P
Sbjct: 492 PAFQVPLGP 500
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 277 bits (708), Expect = 4e-74
Identities = 149/362 (41%), Positives = 220/362 (60%), Gaps = 13/362 (3%)
Query: 28 EVVCNILLLDN-----TVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNP 82
E C +LLLD T Q + K +G V+LD VF H++L E DYFGL+ D S
Sbjct: 10 EFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQT- 68
Query: 83 RWLDPNKPI---RKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRL 139
WLDP K + ++ + G PY+L F +KF+ DP KL+EE TRYQ+FLQ+KQD+L GRL
Sbjct: 69 YWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRL 128
Query: 140 PCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLS 199
PCP NTAA L ++A+QSELGDYD ++ +GY+S+Y F+P+Q ++ E+ I ++H+ +G
Sbjct: 129 PCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQI 188
Query: 200 PAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIV 259
P+EAE NYL TA++LE+YGV+ H ++ +E +G+ G+++YKN+ ++ + W +I
Sbjct: 189 PSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRIT 248
Query: 260 KISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQK 318
K+ FK QF +LR + ET F + ACK+LWK VEHHTFFR+ +
Sbjct: 249 KVHFKETQF--ELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLS 306
Query: 319 NFFAHYFTLGSKFRYCGRTEVQ-SVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNS 377
+ + ++ K RY GRT +Q S + D+ RS SK +++ + NS
Sbjct: 307 RKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAESNS 366
Query: 378 IS 379
IS
Sbjct: 367 IS 368
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 269 bits (687), Expect = 1e-71
Identities = 138/342 (40%), Positives = 214/342 (62%), Gaps = 6/342 (1%)
Query: 29 VVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPN 88
+ C + LLD T + + K +GQ L D + HLDL E DYFGL+ D S WLD
Sbjct: 43 ITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMD-SAQVAHWLDGT 101
Query: 89 KPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAAL 148
K I+KQ+K GSPY L+ RVKF+ S+PN L+EE TRY + LQ+KQDIL+G+L CP +TA
Sbjct: 102 KSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQ 161
Query: 149 LASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYL 208
LA++ +Q+ELGDYD +E+ +S++ F+P Q ++ E I + +++ G +PA+AE NYL
Sbjct: 162 LAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYL 221
Query: 209 NTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQF 268
N A+ LE+YGV+ H + + N+ +G+ G+L+++ ++ F W KI ++ FK +
Sbjct: 222 NKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKL 281
Query: 269 FIQLRKELHESRET--LLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFT 326
+ + ++ + +E F + + +ACK+LWK VEHH FFRL P+ + + + +
Sbjct: 282 TLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPV-QKSSHRSGFIR 340
Query: 327 LGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLM 368
LGS+FRY G+TE Q+ + KA + F R PSK +R+ +
Sbjct: 341 LGSRFRYSGKTEYQTTK--TNKARRSTSFERRPSKRYSRRTL 380
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 262 bits (669), Expect = 1e-69
Identities = 145/334 (43%), Positives = 202/334 (60%), Gaps = 7/334 (2%)
Query: 29 VVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPN 88
V I +LD+T +AF+V + G+VLLD V HL+L E DYFGL+ D WLD
Sbjct: 40 VSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITV-WLDLL 98
Query: 89 KPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAAL 148
KPI KQ++R + F VKFF D +LQEE TRY + LQ+KQD+ GRL C +AAL
Sbjct: 99 KPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAAL 158
Query: 149 LASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYL 208
L S VQSE+GD+D++ + +L+ +IP Q E +I + H HIG +PAE++F L
Sbjct: 159 LISHIVQSEIGDFDEALDRE-HLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQLL 216
Query: 209 NTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQF 268
AR LE+YG+ H A+D+ +I + V + GIL+++ ++N F W K+ K+SFK K+F
Sbjct: 217 EIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF 276
Query: 269 FIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTL 327
I+LR + + + + L F M + CK+ WK CVEHH FFRL + P P K F+
Sbjct: 277 LIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVL---FSR 333
Query: 328 GSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK 361
GS FR+ GRT+ Q + Y KE +K F R SK
Sbjct: 334 GSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSK 367
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 261 bits (666), Expect = 3e-69
Identities = 143/357 (40%), Positives = 211/357 (59%), Gaps = 10/357 (2%)
Query: 7 LPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTE 66
L G ++ A+ A+ + C + LLD T + + KH +GQ L D + HLDL E
Sbjct: 67 LTGGAAVHISAAGAAK----ATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVE 122
Query: 67 QDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQY 126
DYFGLQ D S WLD KPI+KQ+K G Y+L+FRVK++ S+PN L+EE+TRY +
Sbjct: 123 TDYFGLQFLD-SAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLF 181
Query: 127 FLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEK 186
LQ++ DIL+G+L CP TA LA+ +Q+ELG+ + E+ +S++ FIPNQ + E
Sbjct: 182 VLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEF 241
Query: 187 EIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKN 246
+I + ++ G SPA+AE +YLN A+ LE+YGV+ H R + E +G+ GILI++
Sbjct: 242 DIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEG 301
Query: 247 RVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRET--LLGFNMVNYRACKNLWKACVEH 304
++ F W KI K+ FK + + + ++ + RE F + + R CK+LWK VEH
Sbjct: 302 ANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEH 361
Query: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK 361
H FFRL P + N + + LGS+FR+ GRTE Q+ + + F R PSK
Sbjct: 362 HAFFRLRTPGNSKSN-RSDFIRLGSRFRFSGRTEYQATH--GSRLRRTSTFERKPSK 415
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 261 bits (666), Expect = 3e-69
Identities = 143/357 (40%), Positives = 211/357 (59%), Gaps = 10/357 (2%)
Query: 7 LPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTE 66
L G ++ A+ A+ + C + LLD T + + KH +GQ L D + HLDL E
Sbjct: 67 LTGGAAVHISAAGAAK----ATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVE 122
Query: 67 QDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQY 126
DYFGLQ D S WLD KPI+KQ+K G Y+L+FRVK++ S+PN L+EE+TRY +
Sbjct: 123 TDYFGLQFLD-SAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLF 181
Query: 127 FLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEK 186
LQ++ DIL+G+L CP TA LA+ +Q+ELG+ + E+ +S++ FIPNQ + E
Sbjct: 182 VLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEF 241
Query: 187 EIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKN 246
+I + ++ G SPA+AE +YLN A+ LE+YGV+ H R + E +G+ GILI++
Sbjct: 242 DIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEG 301
Query: 247 RVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRET--LLGFNMVNYRACKNLWKACVEH 304
++ F W KI K+ FK + + + ++ + RE F + + R CK+LWK VEH
Sbjct: 302 ANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEH 361
Query: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK 361
H FFRL P + N + + LGS+FR+ GRTE Q+ + + F R PSK
Sbjct: 362 HAFFRLRTPGNSKSN-RSDFIRLGSRFRFSGRTEYQATH--GSRLRRTSTFERKPSK 415
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 257 bits (657), Expect = 3e-68
Identities = 129/285 (45%), Positives = 184/285 (64%), Gaps = 6/285 (2%)
Query: 84 WLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPS 143
WLD K I+KQ+ RG P++ F VKF+ DP +L E+ TRY LQ++QDI+ GRLPC
Sbjct: 229 WLDSAKEIKKQV-RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSF 287
Query: 144 NTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEA 203
T ALL S+ +QSELGDYD + Y+SD+ PNQ ++ E+++ +LH+ + ++PA+A
Sbjct: 288 ATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQA 347
Query: 204 EFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISF 263
+ +L A+ L +YGV+ H A+D +I++GV S G+L+YK+++R+N FPW K++KIS+
Sbjct: 348 DLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISY 407
Query: 264 KCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFA 322
K FFI++R E E+ +GF + +YRA K LWK CVEHHTFFRL P+ F A
Sbjct: 408 KRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLA 467
Query: 323 HYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKL 367
LGSKFRY GRT+ Q+ Q F R+ SK +R L
Sbjct: 468 ----LGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSL 508
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 236 bits (602), Expect = 7e-62
Identities = 131/326 (40%), Positives = 188/326 (57%), Gaps = 7/326 (2%)
Query: 33 ILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIR 92
+ LD++ + F V++ G+ L ++ HL+L E++YFGL+ S +N WL+ KPI
Sbjct: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64
Query: 93 KQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASF 152
KQ+K F VKFF DP L+EE TRY + LQIK+D+ GRLPC N AL+ S
Sbjct: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
Query: 153 AVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTAR 212
+QSELGD+ + + +L+ ++PNQ E +I HQ+HIG SPAE++ L+ AR
Sbjct: 125 ILQSELGDFHEETDRK-HLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLDIAR 182
Query: 213 TLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQL 272
L++YG+ H A D +I + V G+L+ + ++NTF W KI K+SFK K F I+L
Sbjct: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
Query: 273 RKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGSKF 331
+ + L F M + ACK WK CVE+H FFRL + P K + GS F
Sbjct: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLC---SKGSSF 299
Query: 332 RYCGRTEVQSVQYGKEKANKDRVFAR 357
RY GRT+ Q ++YG++ K F R
Sbjct: 300 RYSGRTQRQLLEYGRKGRLKSLPFER 325
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 223 bits (568), Expect = 6e-58
Identities = 111/310 (35%), Positives = 187/310 (60%), Gaps = 4/310 (1%)
Query: 28 EVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDP 87
E C + LLD++ + + +GQ L D++ HL+L E+DYFG++ D WL+
Sbjct: 16 EYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQR-HWLEF 74
Query: 88 NKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAA 147
K + KQL+ P+++ FRVKF+ +DP L+EE TRY FLQIK+D+ GRL C ++ AA
Sbjct: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
Query: 148 LLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHI-GLSPAEAEFN 206
LLA++ +Q+E+GDYD ++ GY S + F P + E++IA++H+ + G +PA +E N
Sbjct: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
Query: 207 YLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCK 266
+L A+TLE YGV+ H +D S N + G ++ + R++ W ++ K+ F+ K
Sbjct: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
Query: 267 QFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFT 326
F++ + ++ E ++ +L + ACK+LWK +E+ F++L++ + ++ F
Sbjct: 255 TFYLYVSQK--EEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFF 312
Query: 327 LGSKFRYCGR 336
GS+FRY GR
Sbjct: 313 KGSRFRYSGR 322
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 221 bits (562), Expect = 3e-57
Identities = 117/318 (36%), Positives = 184/318 (57%), Gaps = 7/318 (2%)
Query: 28 EVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDP 87
E+ C I LLD++ + + + +GQ L+D + + L E+DYFG++ D WL+P
Sbjct: 31 EMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQR-HWLEP 89
Query: 88 NKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAA 147
NK I KQ+K PY++ FRVKF+ +P K++EE TRY +LQIK+DI GRL C + AA
Sbjct: 90 NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149
Query: 148 LLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHI-GLSPAEAEFN 206
L + VQ+ELGDYD E+ Y+S++ P Q Q E++I ++H+ + G SP AEFN
Sbjct: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209
Query: 207 YLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCK 266
L A TLE YGV+ H +D + +G + G ++++ R++ W + K+ F+ K
Sbjct: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269
Query: 267 QFF-IQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYF 325
F+ I +KE ++ +L F+ ACK+LWK VE+ F++ + + + F
Sbjct: 270 TFYVIGTQKE----KKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIF 325
Query: 326 TLGSKFRYCGRTEVQSVQ 343
GS+FRY G+ + V+
Sbjct: 326 FKGSRFRYSGKVAKEVVE 343
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [Homo
sapiens]
Length = 1187
Score = 203 bits (516), Expect = 7e-52
Identities = 106/282 (37%), Positives = 164/282 (58%), Gaps = 19/282 (6%)
Query: 646 LAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVIL----KGN 701
L + L G V T+++Q+ +KK S A LP+N ++R R++ PY+ RV L + N
Sbjct: 900 LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN 959
Query: 702 EDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRV 761
YINA++I + + + YIA QGPLPHTC DFWQM WEQG +++ M+T + E GR
Sbjct: 960 TGYINASHIKVVVGGAEW--HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT 1017
Query: 762 KCHQYWPE---PTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAW 818
K H+YWP+ S++YG ++VT + Y + + + + R + +QY W
Sbjct: 1018 KSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDW 1077
Query: 819 PDHGVPDDSSDFLDFVCHVRNKR----------AGKEEPVVVHCSAGIGRTGVLITMETA 868
PDHG P+D FL ++ +++ R + P+VVHCSAG+GRTGVLI E
Sbjct: 1078 PDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELM 1137
Query: 869 MCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK 910
+ +E N+ V ++R +R+QR MIQT +QY+FV + +++
Sbjct: 1138 IYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179
Score = 136 bits (343), Expect = 8e-32
Identities = 93/300 (31%), Positives = 150/300 (50%), Gaps = 18/300 (6%)
Query: 30 VCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNK 89
V I LLD+ V ++ GQ L+ V + L+L E YFGL S RW++ K
Sbjct: 22 VTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKS-QQARWVELEK 80
Query: 90 PIRKQL-KRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAAL 148
P++K L K + L F V F+V + + LQ+E TRYQY+LQ+K+D+L GRL C +
Sbjct: 81 PLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIR 140
Query: 149 LASFAVQSELGDYDQSENLSGYLSDYSFIPNQ-------PQDFEKEIAKLHQQHIGLSPA 201
LA AVQ++ GDY+Q ++ +L +Y P ++ +++A+ H+ H G+ PA
Sbjct: 141 LAGLAVQADFGDYNQFDS-QDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199
Query: 202 EAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT--FPWLKIV 259
EAE Y+N L+ +G E +D N + +G+ GI + +NR+ + W +
Sbjct: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV-RNRIGRQAVIYRWNDMG 258
Query: 260 KISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKN 319
I+ + EL ET L F+ + K + + H F++ ++ Q N
Sbjct: 259 NITHNKSTILV----ELINKEETAL-FHTDDIENAKYISRLFATRHKFYKQNKICTEQSN 313
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 186 bits (473), Expect = 7e-47
Identities = 104/275 (37%), Positives = 156/275 (56%), Gaps = 9/275 (3%)
Query: 641 ESMIQLAEGLIT-GTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK 699
+S+I++ GL+ G + + L KP + +N KNRY++I PYDATRV L
Sbjct: 2203 KSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG 2262
Query: 700 GNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG 759
YINA++I + + + YIACQGPLP T DFWQM WEQ S+++ M+T +VE
Sbjct: 2263 DEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGE 2320
Query: 760 RVKCHQYWPEPTGSSSY--GCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIA 817
++KC +YWP G ++ ++ + ++ R MTL + + E R ++ + + A
Sbjct: 2321 KIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2380
Query: 818 WPDHGVPDDSSDFLDFVCHVRN-KRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQ 876
WPDH P D L F+ ++R+ R+G P++ HCSAGIGR+G LI ++ + LI +
Sbjct: 2381 WPDHDTPSQPDDLLTFISYMRHIHRSG---PIITHCSAGIGRSGTLICIDVVLGLISQDL 2437
Query: 877 PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV 911
D+VR MR QR M+QT QY F + IL V
Sbjct: 2438 DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2472
Score = 145 bits (365), Expect = 2e-34
Identities = 172/683 (25%), Positives = 285/683 (41%), Gaps = 93/683 (13%)
Query: 32 NILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPI 91
NI+LL+ + + + D+V H+ L E F L D+ ++DP+ +
Sbjct: 575 NIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDN--EYFFVDPDLKL 632
Query: 92 ------------RKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRL 139
+K+ K ++L FR+KFF+ D + +Q T +QY+LQ+++DIL R+
Sbjct: 633 TKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 140 PCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQD------FEKEIAKLHQ 193
C T+ LLAS A+Q+E GDY + Y ++P + + ++E+ KLH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHN 752
Query: 194 QHIGLSPAEAEFNYLNTARTLELYGVEFH--YARDQSNNEIMIGVMSGGILIYK--NRVR 249
++G S E E +L + L YGV FH + +S I++GV S G+L+++ N VR
Sbjct: 753 TYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVR 812
Query: 250 --MNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTF 307
+ FPW + KISF K+ +Q + S GF N + C+ L C H F
Sbjct: 813 TLVLRFPWRETKKISFSKKKITLQ-----NTSDGIKHGFQTDNSKICQYLLHLCSYQHKF 867
Query: 308 FRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQ-YGKEKANKDRVFARSPSKPLARK 366
R Q N A S FR + +SV+ + +A A S LA +
Sbjct: 868 QLQMR--ARQSNQDAQDIERAS-FRSL-NLQAESVRGFNMGRAISTGSLASSTLNKLAVR 923
Query: 367 --LMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMV 424
+ E++ R S S+ L P ++ N + S +E R S L +
Sbjct: 924 PLSVQAEILKRLSCSELSLYQ---PLQNSSKEKNDKAS--WEEKPREMSKSYHDLSQASL 978
Query: 425 HTSPSEVFVNQRSPSSTQANSIVLESSPS-QETPGDGKPPALPPKQSKKNSWNQIHYSHS 483
+ V VN P T A L PS Q + D + A K + S ++ S
Sbjct: 979 YPHRKNVIVNMEPPPQTVAE---LVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPE 1035
Query: 484 QQDLESHINETFDI--------------PSSPEKPTPNGGI----------PHDNLVLIR 519
++ ES + D SS + P + P + L+
Sbjct: 1036 RRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVN 1095
Query: 520 MKPDENGRFGFNVKGGYDQ---KMPVIVSRVAPGTPADL--CVPRLNEGDQVVLINGRDI 574
+K D GF + GG + + +S VAPG PADL C L GD+++ +N +
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSL 1152
Query: 575 AEHTHDQVVLFIKASCERHSGELMLLVR---------PNAVYDVVEEKLENEPDFQYIPE 625
+H + ++ + E ++ L++ P+ + E Y+ +
Sbjct: 1153 EGVSHHAAIEILQNAPE----DVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQD 1208
Query: 626 KAPLDSVHQDDHSLRESMIQLAE 648
A +DS +D H R ++ ++E
Sbjct: 1209 SA-IDSSSKDHHWSRGTLRHISE 1230
Score = 39.7 bits (91), Expect = 0.013
Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 11/146 (7%)
Query: 452 PSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIP 511
P++ D P LPP + S+ S S ++ + P+ E TP
Sbjct: 1720 PNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDL 1779
Query: 512 HDNL--------VLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEG 563
++L +LI + E G GF V G + + + +D RL G
Sbjct: 1780 ENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSD---GRLKPG 1836
Query: 564 DQVVLINGRDIAEHTHDQVVLFIKAS 589
D+++ +N D+ TH V ++A+
Sbjct: 1837 DRLIKVNDTDVTNMTHTDAVNLLRAA 1862
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 186 bits (473), Expect = 7e-47
Identities = 104/275 (37%), Positives = 156/275 (56%), Gaps = 9/275 (3%)
Query: 641 ESMIQLAEGLIT-GTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK 699
+S+I++ GL+ G + + L KP + +N KNRY++I PYDATRV L
Sbjct: 2007 KSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG 2066
Query: 700 GNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG 759
YINA++I + + + YIACQGPLP T DFWQM WEQ S+++ M+T +VE
Sbjct: 2067 DEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGE 2124
Query: 760 RVKCHQYWPEPTGSSSY--GCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIA 817
++KC +YWP G ++ ++ + ++ R MTL + + E R ++ + + A
Sbjct: 2125 KIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2184
Query: 818 WPDHGVPDDSSDFLDFVCHVRN-KRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQ 876
WPDH P D L F+ ++R+ R+G P++ HCSAGIGR+G LI ++ + LI +
Sbjct: 2185 WPDHDTPSQPDDLLTFISYMRHIHRSG---PIITHCSAGIGRSGTLICIDVVLGLISQDL 2241
Query: 877 PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV 911
D+VR MR QR M+QT QY F + IL V
Sbjct: 2242 DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
Score = 129 bits (323), Expect = 2e-29
Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 31/300 (10%)
Query: 32 NILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPI 91
NI+LL+ + + + D+V H+ L E F L D+ ++DP+ +
Sbjct: 575 NIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDN--EYFFVDPDLKL 632
Query: 92 ------------RKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRL 139
+K+ K ++L FR+KFF+ D + +Q T +QY+LQ+++DIL R+
Sbjct: 633 TKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 140 PCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQD------FEKEIAKLHQ 193
C T+ LLAS A+Q+E GDY + Y ++P + + ++E+ KLH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHN 752
Query: 194 QHIGLSPAEAEFNYLNTARTLELYGVEFH--YARDQSNNEIMIGVMSGGILIYK--NRVR 249
++G S E E +L + L YGV FH + +S I++GV S G+L+++ N VR
Sbjct: 753 TYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVR 812
Query: 250 --MNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTF 307
+ FPW + KISF K+ +Q + S GF N + C+ L C H F
Sbjct: 813 TLVLRFPWRETKKISFSKKKITLQ-----NTSDGIKHGFQTDNSKICQYLLHLCSYQHKF 867
Score = 41.6 bits (96), Expect = 0.003
Identities = 43/188 (22%), Positives = 81/188 (43%), Gaps = 34/188 (18%)
Query: 477 QIHYSHSQQDLESH--INETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKG 534
Q+ S QD + +++ + I SSPE+ + L+ +K D GF + G
Sbjct: 870 QMRARQSNQDAQDIDVLHKRWSIVSSPER----------EITLVNLKKDAKYGLGFQIIG 919
Query: 535 GYDQ---KMPVIVSRVAPGTPADL--CVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKAS 589
G + + +S VAPG PADL C L GD+++ +N + +H + ++ +
Sbjct: 920 GEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSHHAAIEILQNA 976
Query: 590 CERHSGELMLLVR---------PNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLR 640
E ++ L++ P+ + E Y+ + A +DS +D H R
Sbjct: 977 PE----DVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSA-IDSSSKDHHWSR 1031
Query: 641 ESMIQLAE 648
++ ++E
Sbjct: 1032 GTLRHISE 1039
Score = 39.7 bits (91), Expect = 0.013
Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 11/146 (7%)
Query: 452 PSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIP 511
P++ D P LPP + S+ S S ++ + P+ E TP
Sbjct: 1524 PNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDL 1583
Query: 512 HDNL--------VLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEG 563
++L +LI + E G GF V G + + + +D RL G
Sbjct: 1584 ENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSD---GRLKPG 1640
Query: 564 DQVVLINGRDIAEHTHDQVVLFIKAS 589
D+++ +N D+ TH V ++A+
Sbjct: 1641 DRLIKVNDTDVTNMTHTDAVNLLRAA 1666
Score = 31.2 bits (69), Expect = 4.7
Identities = 41/175 (23%), Positives = 70/175 (40%), Gaps = 34/175 (19%)
Query: 425 HTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQ 484
H SPS +++ + T S +T G + ++ YS SQ
Sbjct: 1088 HGSPSPSVISKATEKET------FTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQ 1141
Query: 485 ------QDLESHIN-------ETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFN 531
Q+ S +N +TF SSP KP ++ + + ++N G +
Sbjct: 1142 DHQTPKQESSSSVNTSNKMNFKTFS--SSPPKP--------GDIFEVELAKNDNS-LGIS 1190
Query: 532 VKGGYDQKMP---VIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVV 583
V GG + + + V V P A+ R+++GD+V+ +NG + TH Q V
Sbjct: 1191 VTGGVNTSVRHGGIYVKAVIPQGAAE-SDGRIHKGDRVLAVNGVSLEGATHKQAV 1244
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 186 bits (473), Expect = 7e-47
Identities = 104/275 (37%), Positives = 156/275 (56%), Gaps = 9/275 (3%)
Query: 641 ESMIQLAEGLIT-GTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK 699
+S+I++ GL+ G + + L KP + +N KNRY++I PYDATRV L
Sbjct: 2198 KSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG 2257
Query: 700 GNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG 759
YINA++I + + + YIACQGPLP T DFWQM WEQ S+++ M+T +VE
Sbjct: 2258 DEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGE 2315
Query: 760 RVKCHQYWPEPTGSSSY--GCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIA 817
++KC +YWP G ++ ++ + ++ R MTL + + E R ++ + + A
Sbjct: 2316 KIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2375
Query: 818 WPDHGVPDDSSDFLDFVCHVRN-KRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQ 876
WPDH P D L F+ ++R+ R+G P++ HCSAGIGR+G LI ++ + LI +
Sbjct: 2376 WPDHDTPSQPDDLLTFISYMRHIHRSG---PIITHCSAGIGRSGTLICIDVVLGLISQDL 2432
Query: 877 PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV 911
D+VR MR QR M+QT QY F + IL V
Sbjct: 2433 DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2467
Score = 145 bits (365), Expect = 2e-34
Identities = 172/683 (25%), Positives = 285/683 (41%), Gaps = 93/683 (13%)
Query: 32 NILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPI 91
NI+LL+ + + + D+V H+ L E F L D+ ++DP+ +
Sbjct: 575 NIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDN--EYFFVDPDLKL 632
Query: 92 ------------RKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRL 139
+K+ K ++L FR+KFF+ D + +Q T +QY+LQ+++DIL R+
Sbjct: 633 TKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 140 PCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQD------FEKEIAKLHQ 193
C T+ LLAS A+Q+E GDY + Y ++P + + ++E+ KLH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHN 752
Query: 194 QHIGLSPAEAEFNYLNTARTLELYGVEFH--YARDQSNNEIMIGVMSGGILIYK--NRVR 249
++G S E E +L + L YGV FH + +S I++GV S G+L+++ N VR
Sbjct: 753 TYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVR 812
Query: 250 --MNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTF 307
+ FPW + KISF K+ +Q + S GF N + C+ L C H F
Sbjct: 813 TLVLRFPWRETKKISFSKKKITLQ-----NTSDGIKHGFQTDNSKICQYLLHLCSYQHKF 867
Query: 308 FRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQ-YGKEKANKDRVFARSPSKPLARK 366
R Q N A S FR + +SV+ + +A A S LA +
Sbjct: 868 QLQMR--ARQSNQDAQDIERAS-FRSL-NLQAESVRGFNMGRAISTGSLASSTLNKLAVR 923
Query: 367 --LMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMV 424
+ E++ R S S+ L P ++ N + S +E R S L +
Sbjct: 924 PLSVQAEILKRLSCSELSLYQ---PLQNSSKEKNDKAS--WEEKPREMSKSYHDLSQASL 978
Query: 425 HTSPSEVFVNQRSPSSTQANSIVLESSPS-QETPGDGKPPALPPKQSKKNSWNQIHYSHS 483
+ V VN P T A L PS Q + D + A K + S ++ S
Sbjct: 979 YPHRKNVIVNMEPPPQTVAE---LVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPE 1035
Query: 484 QQDLESHINETFDI--------------PSSPEKPTPNGGI----------PHDNLVLIR 519
++ ES + D SS + P + P + L+
Sbjct: 1036 RRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVN 1095
Query: 520 MKPDENGRFGFNVKGGYDQ---KMPVIVSRVAPGTPADL--CVPRLNEGDQVVLINGRDI 574
+K D GF + GG + + +S VAPG PADL C L GD+++ +N +
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSL 1152
Query: 575 AEHTHDQVVLFIKASCERHSGELMLLVR---------PNAVYDVVEEKLENEPDFQYIPE 625
+H + ++ + E ++ L++ P+ + E Y+ +
Sbjct: 1153 EGVSHHAAIEILQNAPE----DVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQD 1208
Query: 626 KAPLDSVHQDDHSLRESMIQLAE 648
A +DS +D H R ++ ++E
Sbjct: 1209 SA-IDSSSKDHHWSRGTLRHISE 1230
Score = 39.7 bits (91), Expect = 0.013
Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 11/146 (7%)
Query: 452 PSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIP 511
P++ D P LPP + S+ S S ++ + P+ E TP
Sbjct: 1715 PNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDL 1774
Query: 512 HDNL--------VLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEG 563
++L +LI + E G GF V G + + + +D RL G
Sbjct: 1775 ENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSD---GRLKPG 1831
Query: 564 DQVVLINGRDIAEHTHDQVVLFIKAS 589
D+++ +N D+ TH V ++A+
Sbjct: 1832 DRLIKVNDTDVTNMTHTDAVNLLRAA 1857
Score = 31.2 bits (69), Expect = 4.7
Identities = 41/175 (23%), Positives = 70/175 (40%), Gaps = 34/175 (19%)
Query: 425 HTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQ 484
H SPS +++ + T S +T G + ++ YS SQ
Sbjct: 1279 HGSPSPSVISKATEKET------FTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQ 1332
Query: 485 ------QDLESHIN-------ETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFN 531
Q+ S +N +TF SSP KP ++ + + ++N G +
Sbjct: 1333 DHQTPKQESSSSVNTSNKMNFKTFS--SSPPKP--------GDIFEVELAKNDNS-LGIS 1381
Query: 532 VKGGYDQKMP---VIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVV 583
V GG + + + V V P A+ R+++GD+V+ +NG + TH Q V
Sbjct: 1382 VTGGVNTSVRHGGIYVKAVIPQGAAE-SDGRIHKGDRVLAVNGVSLEGATHKQAV 1435
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 186 bits (473), Expect = 7e-47
Identities = 104/275 (37%), Positives = 156/275 (56%), Gaps = 9/275 (3%)
Query: 641 ESMIQLAEGLIT-GTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK 699
+S+I++ GL+ G + + L KP + +N KNRY++I PYDATRV L
Sbjct: 2179 KSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG 2238
Query: 700 GNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG 759
YINA++I + + + YIACQGPLP T DFWQM WEQ S+++ M+T +VE
Sbjct: 2239 DEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGE 2296
Query: 760 RVKCHQYWPEPTGSSSY--GCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIA 817
++KC +YWP G ++ ++ + ++ R MTL + + E R ++ + + A
Sbjct: 2297 KIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2356
Query: 818 WPDHGVPDDSSDFLDFVCHVRN-KRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQ 876
WPDH P D L F+ ++R+ R+G P++ HCSAGIGR+G LI ++ + LI +
Sbjct: 2357 WPDHDTPSQPDDLLTFISYMRHIHRSG---PIITHCSAGIGRSGTLICIDVVLGLISQDL 2413
Query: 877 PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV 911
D+VR MR QR M+QT QY F + IL V
Sbjct: 2414 DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2448
Score = 149 bits (377), Expect = 9e-36
Identities = 172/674 (25%), Positives = 287/674 (42%), Gaps = 94/674 (13%)
Query: 32 NILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPI 91
NI+LL+ + + + D+V H+ L E F L D+ ++DP+ +
Sbjct: 575 NIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDN--EYFFVDPDLKL 632
Query: 92 ------------RKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRL 139
+K+ K ++L FR+KFF+ D + +Q T +QY+LQ+++DIL R+
Sbjct: 633 TKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
Query: 140 PCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQD------FEKEIAKLHQ 193
C T+ LLAS A+Q+E GDY + Y ++P + + ++E+ KLH
Sbjct: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHN 752
Query: 194 QHIGLSPAEAEFNYLNTARTLELYGVEFH--YARDQSNNEIMIGVMSGGILIYK--NRVR 249
++G S E E +L + L YGV FH + +S I++GV S G+L+++ N VR
Sbjct: 753 TYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVR 812
Query: 250 --MNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTF 307
+ FPW + KISF K+ +Q + S GF N + C+ L C H F
Sbjct: 813 TLVLRFPWRETKKISFSKKKITLQ-----NTSDGIKHGFQTDNSKICQYLLHLCSYQHKF 867
Query: 308 FRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQ-YGKEKANKDRVFARSPSKPLARK 366
R Q N A S FR + +SV+ + +A A S LA +
Sbjct: 868 QLQMR--ARQSNQDAQDIERAS-FRSL-NLQAESVRGFNMGRAISTGSLASSTLNKLAVR 923
Query: 367 --LMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMV 424
+ E++ R S S+ L P ++ N + S +E R S L +
Sbjct: 924 PLSVQAEILKRLSCSELSLYQ---PLQNSSKEKNDKAS--WEEKPREMSKSYHDLSQASL 978
Query: 425 HTSPSEVFVNQRSPSSTQANSIVLESSPS-QETPGDGKPPALPPKQSKKNSWNQIHYSHS 483
+ V VN P T A L PS Q + D + A K + S ++ S
Sbjct: 979 YPHRKNVIVNMEPPPQTVAE---LVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPE 1035
Query: 484 QQDLESH---------------INETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRF 528
++ ES +++ + I SSPE+ + L+ +K D
Sbjct: 1036 RRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPER----------EITLVNLKKDAKYGL 1085
Query: 529 GFNVKGGYDQ---KMPVIVSRVAPGTPADL--CVPRLNEGDQVVLINGRDIAEHTHDQVV 583
GF + GG + + +S VAPG PADL C L GD+++ +N + +H +
Sbjct: 1086 GFQIIGGEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSHHAAI 1142
Query: 584 LFIKASCERHSGELMLLVR---------PNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQ 634
++ + E ++ L++ P+ + E Y+ + A +DS +
Sbjct: 1143 EILQNAPE----DVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSA-IDSSSK 1197
Query: 635 DDHSLRESMIQLAE 648
D H R ++ ++E
Sbjct: 1198 DHHWSRGTLRHISE 1211
Score = 39.7 bits (91), Expect = 0.013
Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 11/146 (7%)
Query: 452 PSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIP 511
P++ D P LPP + S+ S S ++ + P+ E TP
Sbjct: 1696 PNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDL 1755
Query: 512 HDNL--------VLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEG 563
++L +LI + E G GF V G + + + +D RL G
Sbjct: 1756 ENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSD---GRLKPG 1812
Query: 564 DQVVLINGRDIAEHTHDQVVLFIKAS 589
D+++ +N D+ TH V ++A+
Sbjct: 1813 DRLIKVNDTDVTNMTHTDAVNLLRAA 1838
Score = 31.2 bits (69), Expect = 4.7
Identities = 41/175 (23%), Positives = 70/175 (40%), Gaps = 34/175 (19%)
Query: 425 HTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQ 484
H SPS +++ + T S +T G + ++ YS SQ
Sbjct: 1260 HGSPSPSVISKATEKET------FTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQ 1313
Query: 485 ------QDLESHIN-------ETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFN 531
Q+ S +N +TF SSP KP ++ + + ++N G +
Sbjct: 1314 DHQTPKQESSSSVNTSNKMNFKTFS--SSPPKP--------GDIFEVELAKNDNS-LGIS 1362
Query: 532 VKGGYDQKMP---VIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVV 583
V GG + + + V V P A+ R+++GD+V+ +NG + TH Q V
Sbjct: 1363 VTGGVNTSVRHGGIYVKAVIPQGAAE-SDGRIHKGDRVLAVNGVSLEGATHKQAV 1416
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,068,265
Number of Sequences: 37866
Number of extensions: 1856728
Number of successful extensions: 6534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 151
Number of HSP's that attempted gapping in prelim test: 5519
Number of HSP's gapped (non-prelim): 638
length of query: 926
length of database: 18,247,518
effective HSP length: 112
effective length of query: 814
effective length of database: 14,006,526
effective search space: 11401312164
effective search space used: 11401312164
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.