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Search of human proteins with 4506265
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506265 prostaglandin-endoperoxide synthase 2 precursor
[Homo sapiens]
(604 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506265 prostaglandin-endoperoxide synthase 2 precursor [Homo... 1251 0.0
gi|18104967 prostaglandin-endoperoxide synthase 1 isoform 1 prec... 787 0.0
gi|18104969 prostaglandin-endoperoxide synthase 1 isoform 2 prec... 727 0.0
gi|109150416 peroxidasin [Homo sapiens] 60 6e-09
gi|28558982 thyroid peroxidase isoform a [Homo sapiens] 57 6e-08
gi|28558984 thyroid peroxidase isoform b [Homo sapiens] 57 6e-08
gi|28558988 thyroid peroxidase isoform d [Homo sapiens] 57 6e-08
gi|126517478 peroxidasin homolog-like [Homo sapiens] 52 2e-06
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 51 3e-06
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 51 3e-06
gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens] 47 7e-05
gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens] 47 7e-05
gi|20149640 dual oxidase 1 precursor [Homo sapiens] 47 7e-05
gi|28872751 dual oxidase 1 precursor [Homo sapiens] 47 7e-05
gi|4759146 slit homolog 2 [Homo sapiens] 46 1e-04
gi|24041035 notch 2 preproprotein [Homo sapiens] 45 1e-04
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 45 1e-04
gi|4557759 myeloperoxidase [Homo sapiens] 45 2e-04
gi|132566532 dual oxidase 2 precursor [Homo sapiens] 44 6e-04
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 43 0.001
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 43 0.001
gi|134244285 Notch homolog 3 [Homo sapiens] 42 0.002
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 42 0.002
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 42 0.002
gi|74136023 delta-like 1 homolog [Homo sapiens] 41 0.003
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 40 0.005
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 40 0.005
gi|4557679 jagged 1 precursor [Homo sapiens] 40 0.008
gi|148833508 notch1 preproprotein [Homo sapiens] 40 0.008
gi|38348304 von Willebrand factor A domain containing 2 [Homo sa... 40 0.008
>gi|4506265 prostaglandin-endoperoxide synthase 2 precursor [Homo
sapiens]
Length = 604
Score = 1251 bits (3237), Expect = 0.0
Identities = 604/604 (100%), Positives = 604/604 (100%)
Query: 1 MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL 60
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
Sbjct: 1 MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL 60
Query: 61 TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY 120
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
Sbjct: 61 TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY 120
Query: 121 GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS 180
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
Sbjct: 121 GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS 180
Query: 181 NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY 240
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
Sbjct: 181 NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY 240
Query: 241 QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD 300
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
Sbjct: 241 QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD 300
Query: 301 VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ 360
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
Sbjct: 301 VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ 360
Query: 361 NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV 420
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
Sbjct: 361 NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV 420
Query: 421 AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL 480
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
Sbjct: 421 AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL 480
Query: 481 YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV 540
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
Sbjct: 481 YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV 540
Query: 541 GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER 600
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
Sbjct: 541 GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER 600
Query: 601 STEL 604
STEL
Sbjct: 601 STEL 604
>gi|18104967 prostaglandin-endoperoxide synthase 1 isoform 1
precursor [Homo sapiens]
Length = 599
Score = 787 bits (2033), Expect = 0.0
Identities = 357/552 (64%), Positives = 446/552 (80%), Gaps = 1/552 (0%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYIL 78
NPCC +PCQ++G+C+ G D+Y+CDCTRTG+ G NC+ P T ++ L+P+P+ H++L
Sbjct: 33 NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLL 92
Query: 79 THFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRAL 138
TH + FW VN F+R +M VLT RS+LI SPPTYN+ + Y SWE+FSN+SYYTR L
Sbjct: 93 THGRWFWEFVN-ATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRIL 151
Query: 139 PPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKT 198
P VP DCPTP+G KGKKQLPD+ + + LLRRKFIPDPQG+N+MFAFFAQHFTHQFFKT
Sbjct: 152 PSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKT 211
Query: 199 DHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAE 258
K GP FT LGHGVDL HIYG+ L RQ +LRLFKDGK+KYQ++DGEMYPP+V++
Sbjct: 212 SGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVL 271
Query: 259 MIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTS 318
M YP +P + AVGQEVFGL+PGLM+YAT+WLREHNRVCD+LK EHP WGDEQLFQT+
Sbjct: 272 MHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTT 331
Query: 319 RLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLP 378
RLILIGETIKIVIE+YVQ LSGY +LKFDPELLF QFQY+NRIA EFN LYHWHPL+P
Sbjct: 332 RLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMP 391
Query: 379 DTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASI 438
D+F++ Q+Y+Y+QF++N S+L+++G+ V++F+RQIAGR+ GGRN+ + V+ I
Sbjct: 392 DSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVI 451
Query: 439 DQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKP 498
+SR+M+ Q FNEYRKRF +KPY SF+EL GEKEM+AELE LYGDIDA+E YP LL+EK
Sbjct: 452 RESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKC 511
Query: 499 RPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNV 558
P++IFGE+M+E+GAPFSLKGL+GN ICSP YWKPSTFGGEVGF I+ TA+++ L+C N
Sbjct: 512 HPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNT 571
Query: 559 KGCPFTSFSVPD 570
K CP+ SF VPD
Sbjct: 572 KTCPYVSFRVPD 583
>gi|18104969 prostaglandin-endoperoxide synthase 1 isoform 2
precursor [Homo sapiens]
Length = 562
Score = 727 bits (1876), Expect = 0.0
Identities = 340/552 (61%), Positives = 415/552 (75%), Gaps = 38/552 (6%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYIL 78
NPCC +PCQ++G+C+ G D+Y+CDCTRTG+ G NC+ P T ++ L+P+P+ H++L
Sbjct: 33 NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLL 92
Query: 79 THFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRAL 138
TH + FW VN F+R +M VLT RS+LI SPPTYN+ + Y SWE+FSN+SYYTR L
Sbjct: 93 THGRWFWEFVN-ATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRIL 151
Query: 139 PPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKT 198
P VP DCPTP+G KGKKQLPD+ + + LLRRKFIPDPQG+N+MFAFFAQHFTHQFFKT
Sbjct: 152 PSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKT 211
Query: 199 DHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAE 258
K GP FT LGHGVDL HIYG+ L RQ +LRLFKDGK+KYQ++DGEMYPP+V++
Sbjct: 212 SGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVL 271
Query: 259 MIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTS 318
M YP +P + AVGQEVFGL+PGLM+YAT+WLREHNRVCD+LK EHP WGDEQLFQT+
Sbjct: 272 MHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTT 331
Query: 319 RLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLP 378
RLILIGETIKIVIE+YVQ LSGY +LKFDPELLF QFQY+NRIA EFN LYHWHPL+P
Sbjct: 332 RLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMP 391
Query: 379 DTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASI 438
D+F ++ GGRN+ + V+ I
Sbjct: 392 DSF-------------------------------------KIGGGRNMDHHILHVAVDVI 414
Query: 439 DQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKP 498
+SR+M+ Q FNEYRKRF +KPY SF+EL GEKEM+AELE LYGDIDA+E YP LL+EK
Sbjct: 415 RESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKC 474
Query: 499 RPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNV 558
P++IFGE+M+E+GAPFSLKGL+GN ICSP YWKPSTFGGEVGF I+ TA+++ L+C N
Sbjct: 475 HPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNT 534
Query: 559 KGCPFTSFSVPD 570
K CP+ SF VPD
Sbjct: 535 KTCPYVSFRVPD 546
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 60.1 bits (144), Expect = 6e-09
Identities = 79/346 (22%), Positives = 137/346 (39%), Gaps = 60/346 (17%)
Query: 208 NGLGHGVDLNHIYGETLARQRKLRLFKD--GKMKYQIID--GEMYPPTVKDTQAEMIYPP 263
N L +D +++YG T R +R G ++ I+ G+ P E +
Sbjct: 904 NQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDE 963
Query: 264 QVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILI 323
F G GL T+W REHNR+ L + +P W + ++ +R I+
Sbjct: 964 NESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVG 1023
Query: 324 GETIKIVIEDYVQHLSG---------YHFKLKFDPEL---LFNK----QFQYQNRIAAEF 367
E I + ++ + G YH +DP + +FN F++ + +
Sbjct: 1024 AEIQHITYQHWLPKILGEVGMRTLGEYH---GYDPGINAGIFNAFATAAFRFGHTLVNPL 1080
Query: 368 NTLY----HWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGG 423
LY ++ P+ D +H + F I+ E GI + R + G VAG
Sbjct: 1081 --LYRLDENFQPIAQDHLPLH------KAFFSPFRIVNEGGI----DPLLRGLFG-VAGK 1127
Query: 424 RNVPPAVQK-----------------VSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEE 466
VP + ++ +I + R +++YR L +FE+
Sbjct: 1128 MRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFED 1187
Query: 467 LTGE---KEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMV 509
L E E+ +L+ LYG ++L+PAL+VE P + G T++
Sbjct: 1188 LKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLM 1233
>gi|28558982 thyroid peroxidase isoform a [Homo sapiens]
Length = 933
Score = 56.6 bits (135), Expect = 6e-08
Identities = 40/142 (28%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 208 NGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQII-----DGEMYPPTVKDTQAEMIYP 262
NGL +D + +YG + A +R+LR + + ++ G Y P V P
Sbjct: 318 NGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAP 377
Query: 263 -PQVPEHLR---FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTS 318
P +P R F G VP L T+WLREHNR+ LK + W + ++Q +
Sbjct: 378 EPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEA 437
Query: 319 RLILIGETIKIVIEDYVQHLSG 340
R ++ I + DY+ + G
Sbjct: 438 RKVVGALHQIITLRDYIPRILG 459
>gi|28558984 thyroid peroxidase isoform b [Homo sapiens]
Length = 876
Score = 56.6 bits (135), Expect = 6e-08
Identities = 40/142 (28%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 208 NGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQII-----DGEMYPPTVKDTQAEMIYP 262
NGL +D + +YG + A +R+LR + + ++ G Y P V P
Sbjct: 318 NGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAP 377
Query: 263 -PQVPEHLR---FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTS 318
P +P R F G VP L T+WLREHNR+ LK + W + ++Q +
Sbjct: 378 EPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEA 437
Query: 319 RLILIGETIKIVIEDYVQHLSG 340
R ++ I + DY+ + G
Sbjct: 438 RKVVGALHQIITLRDYIPRILG 459
>gi|28558988 thyroid peroxidase isoform d [Homo sapiens]
Length = 889
Score = 56.6 bits (135), Expect = 6e-08
Identities = 40/142 (28%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 208 NGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQII-----DGEMYPPTVKDTQAEMIYP 262
NGL +D + +YG + A +R+LR + + ++ G Y P V P
Sbjct: 318 NGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAP 377
Query: 263 -PQVPEHLR---FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTS 318
P +P R F G VP L T+WLREHNR+ LK + W + ++Q +
Sbjct: 378 EPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEA 437
Query: 319 RLILIGETIKIVIEDYVQHLSG 340
R ++ I + DY+ + G
Sbjct: 438 RKVVGALHQIITLRDYIPRILG 459
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 52.0 bits (123), Expect = 2e-06
Identities = 76/341 (22%), Positives = 136/341 (39%), Gaps = 63/341 (18%)
Query: 214 VDLNHIYGETLARQRKLRLFKDGKMKYQIID-GEMYPPTVKDTQAEMIYPP-----QVPE 267
+D +++YG + +R+ + +D + ++ G +PP+ K PP Q E
Sbjct: 894 IDGSNVYGSS---ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQE 950
Query: 268 HLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETI 327
F G L T+W REHNRV L +P W ++Q +R I+ E
Sbjct: 951 SPCFLAGDHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAE-- 1008
Query: 328 KIVIEDYVQHLSGYHF--KLKFDPELLFNKQFQYQN-----RIAAEFNT----------- 369
+QH++ H+ K+ DP + ++ N I F T
Sbjct: 1009 -------LQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLIN 1061
Query: 370 --LYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRN-- 425
LY + L + + H + + +++ S +++ G ++ R + G A R
Sbjct: 1062 PILYRLNATLGEISEGH---LPFHKALFSPSRIIKEG---GIDPVLRGLFGVAAKWRAPS 1115
Query: 426 ---VPPAVQKVSQAS-----------IDQSRQMKYQSFNEYRKRFMLKPYESFEELTGE- 470
P Q++ A+ I + R + ++R L ++FE+L E
Sbjct: 1116 YLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEI 1175
Query: 471 --KEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMV 509
E+ +L LYG ++L+PAL+VE P G T++
Sbjct: 1176 KDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLM 1216
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 51.2 bits (121), Expect = 3e-06
Identities = 19/38 (50%), Positives = 28/38 (73%), Gaps = 1/38 (2%)
Query: 17 TANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
TA PC S+PC+N G+C G+++Y CDC+ TG+ G +C
Sbjct: 716 TAKPCLSNPCKNNGMCRD-GWNRYVCDCSGTGYLGRSC 752
Score = 40.4 bits (93), Expect = 0.005
Identities = 19/30 (63%), Positives = 22/30 (73%), Gaps = 1/30 (3%)
Query: 26 CQNRGVCMSVGFDQYKCDCTRTGFYGENCS 55
C N GVC SV DQ CDC+RTGF G++CS
Sbjct: 228 CLNGGVC-SVVDDQAVCDCSRTGFRGKDCS 256
Score = 37.7 bits (86), Expect = 0.031
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
C C N+GVC+ +D + CDC+ T F G C+ P
Sbjct: 1127 CQEDSCSNQGVCLQQ-WDGFSCDCSMTSFSGPLCNDP 1162
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 51.2 bits (121), Expect = 3e-06
Identities = 19/38 (50%), Positives = 28/38 (73%), Gaps = 1/38 (2%)
Query: 17 TANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
TA PC S+PC+N G+C G+++Y CDC+ TG+ G +C
Sbjct: 676 TAKPCLSNPCKNNGMCRD-GWNRYVCDCSGTGYLGRSC 712
Score = 40.4 bits (93), Expect = 0.005
Identities = 19/30 (63%), Positives = 22/30 (73%), Gaps = 1/30 (3%)
Query: 26 CQNRGVCMSVGFDQYKCDCTRTGFYGENCS 55
C N GVC SV DQ CDC+RTGF G++CS
Sbjct: 228 CLNGGVC-SVVDDQAVCDCSRTGFRGKDCS 256
Score = 37.7 bits (86), Expect = 0.031
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
C C N+GVC+ +D + CDC+ T F G C+ P
Sbjct: 1087 CQEDSCSNQGVCLQQ-WDGFSCDCSMTSFSGPLCNDP 1122
>gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]
Length = 629
Score = 46.6 bits (109), Expect = 7e-05
Identities = 24/61 (39%), Positives = 35/61 (57%)
Query: 289 TIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFD 348
T++LREHNR+ LK+ +P+W E+L+Q +R IL I DY+ L G H +
Sbjct: 301 TLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIP 360
Query: 349 P 349
P
Sbjct: 361 P 361
>gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]
Length = 712
Score = 46.6 bits (109), Expect = 7e-05
Identities = 24/61 (39%), Positives = 35/61 (57%)
Query: 289 TIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFD 348
T++LREHNR+ LK+ +P+W E+L+Q +R IL I DY+ L G H +
Sbjct: 384 TLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIP 443
Query: 349 P 349
P
Sbjct: 444 P 444
>gi|20149640 dual oxidase 1 precursor [Homo sapiens]
Length = 1551
Score = 46.6 bits (109), Expect = 7e-05
Identities = 66/278 (23%), Positives = 108/278 (38%), Gaps = 44/278 (15%)
Query: 271 FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIV 330
+A G E P L +W R HN L ++HP+W DE+LFQ +R +I I
Sbjct: 232 YAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIA 291
Query: 331 IEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEF--NTLYHWHPLLPDTFQIHDQKY 388
+ +++ F K PE + F I++EF + ++P + +
Sbjct: 292 VYEWLP-----SFLQKTLPEYTGYRPF-LDPSISSEFVAASEQFLSTMVPPGVYMRNASC 345
Query: 389 NYQQFIYNNSIL------------LEHGITQFVE-------SFTRQIAGR-----VAGGR 424
++Q I NS + EH Q E QIA R V R
Sbjct: 346 HFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVR 405
Query: 425 NVPPAVQKVSQ-----ASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAE--- 476
+ P K S+ + + + R + S+ + R L P ++++ S +
Sbjct: 406 DFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVL 465
Query: 477 --LEALYG-DIDAVELYPALLVEKPR-PDAIFGETMVE 510
ALY D+ +EL P L+E R P +F ++E
Sbjct: 466 EATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLE 503
>gi|28872751 dual oxidase 1 precursor [Homo sapiens]
Length = 1551
Score = 46.6 bits (109), Expect = 7e-05
Identities = 66/278 (23%), Positives = 108/278 (38%), Gaps = 44/278 (15%)
Query: 271 FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIV 330
+A G E P L +W R HN L ++HP+W DE+LFQ +R +I I
Sbjct: 232 YAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIA 291
Query: 331 IEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEF--NTLYHWHPLLPDTFQIHDQKY 388
+ +++ F K PE + F I++EF + ++P + +
Sbjct: 292 VYEWLP-----SFLQKTLPEYTGYRPF-LDPSISSEFVAASEQFLSTMVPPGVYMRNASC 345
Query: 389 NYQQFIYNNSIL------------LEHGITQFVE-------SFTRQIAGR-----VAGGR 424
++Q I NS + EH Q E QIA R V R
Sbjct: 346 HFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVR 405
Query: 425 NVPPAVQKVSQ-----ASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAE--- 476
+ P K S+ + + + R + S+ + R L P ++++ S +
Sbjct: 406 DFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVL 465
Query: 477 --LEALYG-DIDAVELYPALLVEKPR-PDAIFGETMVE 510
ALY D+ +EL P L+E R P +F ++E
Sbjct: 466 EATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLE 503
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 45.8 bits (107), Expect = 1e-04
Identities = 19/39 (48%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
NPC S+PC+N G C S D Y+C C GF G++C P
Sbjct: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCP-YGFKGQDCDVP 957
Score = 29.6 bits (65), Expect = 8.4
Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 3/36 (8%)
Query: 21 CCSHPCQNRGVC-MSVG-FDQYKCDCTRTGFYGENC 54
C S+PC++ G C + G D + C C GF GENC
Sbjct: 961 CISNPCKHGGTCHLKEGEEDGFWCICA-DGFEGENC 995
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 45.4 bits (106), Expect = 1e-04
Identities = 19/41 (46%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 16 HTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
H N C SHPC N G C+ G Y+C C G+ G+NC T
Sbjct: 1024 HEINECSSHPCLNEGTCVD-GLGTYRCSCP-LGYTGKNCQT 1062
Score = 39.3 bits (90), Expect = 0.011
Identities = 17/36 (47%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
C SHPC N C +V +Q+ C C TGF G+ C T
Sbjct: 148 CLSHPCANGSTCTTVA-NQFSCKCL-TGFTGQKCET 181
Score = 38.1 bits (87), Expect = 0.023
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Query: 17 TANPC-CSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
T++PC S PC N G C + D Y+C C + GF G+ C
Sbjct: 105 TSHPCFVSRPCLNGGTCHMLSRDTYECTC-QVGFTGKEC 142
Score = 38.1 bits (87), Expect = 0.023
Identities = 17/36 (47%), Positives = 23/36 (63%), Gaps = 2/36 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
N C S+PCQN G C ++ + Y+C C + GF G NC
Sbjct: 759 NECLSNPCQNGGTCDNL-VNGYRCTC-KKGFKGYNC 792
Score = 35.8 bits (81), Expect = 0.12
Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
C ++PCQN G CM G + + C C GF G+ C T
Sbjct: 915 CLANPCQNGGSCMD-GVNTFSCLCL-PGFTGDKCQT 948
Score = 35.0 bits (79), Expect = 0.20
Identities = 14/35 (40%), Positives = 17/35 (48%), Gaps = 1/35 (2%)
Query: 20 PCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
PC PC N G C G ++C+C GF G C
Sbjct: 224 PCAPSPCVNGGTCRQTGDFTFECNCL-PGFEGSTC 257
Score = 35.0 bits (79), Expect = 0.20
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 2/37 (5%)
Query: 20 PCCSHPCQNRGVCM-SVGFDQYKCDCTRTGFYGENCS 55
PC +PC+N VC S F+ Y C C G+ G+ C+
Sbjct: 836 PCSPNPCENAAVCKESPNFESYTCLCA-PGWQGQRCT 871
Score = 33.1 bits (74), Expect = 0.76
Identities = 16/36 (44%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
N C S PC+N G C S + Y C C + GF G +C
Sbjct: 951 NECLSEPCKNGGTC-SDYVNSYTCKC-QAGFDGVHC 984
Score = 32.0 bits (71), Expect = 1.7
Identities = 14/36 (38%), Positives = 18/36 (50%), Gaps = 2/36 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
C S+PC N+G C Y C C + G+NC T
Sbjct: 799 CASNPCLNQGTCFD-DISGYTCHCV-LPYTGKNCQT 832
Score = 31.2 bits (69), Expect = 2.9
Identities = 18/49 (36%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 19 NPCCSHPCQNRGVCMSVG-FDQYKCDCTRTGFYGENC----STPEFLTR 62
+PC + CQN G C++ + C C +GF GE+C S P F++R
Sbjct: 66 DPCEKNRCQNGGTCVAQAMLGKATCRCA-SGFTGEDCQYSTSHPCFVSR 113
Score = 31.2 bits (69), Expect = 2.9
Identities = 14/34 (41%), Positives = 18/34 (52%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S PC N G+C + Y C+C GF G +C
Sbjct: 877 CISKPCMNHGLCHNTQ-GSYMCECP-PGFSGMDC 908
Score = 31.2 bits (69), Expect = 2.9
Identities = 14/34 (41%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S+PCQ+ C S Y+C+C G+ G NC
Sbjct: 1153 CASNPCQHGATC-SDFIGGYRCECV-PGYQGVNC 1184
Score = 30.4 bits (67), Expect = 4.9
Identities = 12/24 (50%), Positives = 15/24 (62%), Gaps = 1/24 (4%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDC 44
C +H CQN GVC+ G + Y C C
Sbjct: 264 CPNHRCQNGGVCVD-GVNTYNCRC 286
Score = 29.6 bits (65), Expect = 8.4
Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 15 SHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
S + C S PC N G C+ + + Y+C+C + G G NC
Sbjct: 605 SDQIDECYSSPCLNDGRCIDL-VNGYQCNC-QPGTSGVNC 642
Score = 29.6 bits (65), Expect = 8.4
Identities = 16/40 (40%), Positives = 22/40 (55%), Gaps = 4/40 (10%)
Query: 19 NPCCSHPCQNRGV--CMSVGFDQYKCDCTRTGFYGENCST 56
N C S+PC + G C+ + D Y C C R+ F G +C T
Sbjct: 1266 NECLSNPCSSEGSLDCIQLTND-YLCVC-RSAFTGRHCET 1303
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/38 (44%), Positives = 26/38 (68%), Gaps = 1/38 (2%)
Query: 17 TANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
+A C S+PC+N VC G++++ CDCT TG++G C
Sbjct: 270 SAKQCDSYPCKNNAVCKD-GWNRFICDCTGTGYWGRTC 306
Score = 37.0 bits (84), Expect = 0.052
Identities = 14/37 (37%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
C C N+GVCM ++ + CDC+ T + G C+ P
Sbjct: 680 CQEDSCANQGVCMQQ-WEGFTCDCSMTSYSGNQCNDP 715
>gi|4557759 myeloperoxidase [Homo sapiens]
Length = 745
Score = 45.1 bits (105), Expect = 2e-04
Identities = 48/190 (25%), Positives = 82/190 (43%), Gaps = 27/190 (14%)
Query: 271 FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIV 330
F G +P L T+ LREHNR+ LK +P W E+L+Q +R I +G ++I+
Sbjct: 399 FLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKI-VGAMVQII 457
Query: 331 -IEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEF-NTLYHWHPLL-PDTFQIHDQK 387
DY+ + G K+ P + RIA F N + H L+ P F++ D +
Sbjct: 458 TYRDYLPLVLGPTAMRKYLPTYR-SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRL-DNR 515
Query: 388 YNYQQ----------FIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQAS 437
Y + F + ++LE GI + G P + + +Q +
Sbjct: 516 YQPMEPNPRVPLSRVFFASWRVVLEGGIDPILR-----------GLMATPAKLNRQNQIA 564
Query: 438 IDQSRQMKYQ 447
+D+ R+ ++
Sbjct: 565 VDEIRERLFE 574
>gi|132566532 dual oxidase 2 precursor [Homo sapiens]
Length = 1548
Score = 43.5 bits (101), Expect = 6e-04
Identities = 21/65 (32%), Positives = 33/65 (50%)
Query: 271 FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIV 330
+A G E P L +W R HN L ++HP+W DE+LFQ +R +I I
Sbjct: 238 YAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIA 297
Query: 331 IEDYV 335
+ +++
Sbjct: 298 VYEWL 302
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 42.7 bits (99), Expect = 0.001
Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 3/45 (6%)
Query: 17 TANPCCS---HPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPE 58
TA+P C+ +PC N G+C + + CDC+ TGF G+ CS E
Sbjct: 201 TADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEE 245
Score = 42.7 bits (99), Expect = 0.001
Identities = 18/38 (47%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Query: 17 TANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
T C S PC+N GVC G++++ CDC TGF G C
Sbjct: 690 TLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVC 726
Score = 38.1 bits (87), Expect = 0.023
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
C C N+GVC+ +D + CDCT T + G C+ P
Sbjct: 1100 CTEESCANQGVCLQQ-WDGFTCDCTMTSYGGPVCNDP 1135
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 42.7 bits (99), Expect = 0.001
Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 3/45 (6%)
Query: 17 TANPCCS---HPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPE 58
TA+P C+ +PC N G+C + + CDC+ TGF G+ CS E
Sbjct: 201 TADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEE 245
Score = 42.7 bits (99), Expect = 0.001
Identities = 18/38 (47%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Query: 17 TANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
T C S PC+N GVC G++++ CDC TGF G C
Sbjct: 659 TLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVC 695
Score = 38.1 bits (87), Expect = 0.023
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
C C N+GVC+ +D + CDCT T + G C+ P
Sbjct: 1060 CTEESCANQGVCLQQ-WDGFTCDCTMTSYGGPVCNDP 1095
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/43 (46%), Positives = 25/43 (58%), Gaps = 4/43 (9%)
Query: 19 NPCCSHPCQNRGVCMS---VGFDQYKCDCTRTGFYGENCSTPE 58
+PC S PC RGVC S G ++ C C R GF G +CS P+
Sbjct: 80 DPCHSGPCAGRGVCQSSVVAGTARFSCRCPR-GFRGPDCSLPD 121
Score = 38.1 bits (87), Expect = 0.023
Identities = 17/37 (45%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 18 ANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
A PC PC+N G C G Y C C GF G+NC
Sbjct: 198 AVPCAPSPCRNGGTCRQSGDLTYDCACL-PGFEGQNC 233
Score = 37.0 bits (84), Expect = 0.052
Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 2/41 (4%)
Query: 16 HTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
H A+PC S PC + GVC S ++C C + F G C T
Sbjct: 961 HEADPCLSRPCLHGGVC-SAAHPGFRCTCLES-FTGPQCQT 999
Score = 34.3 bits (77), Expect = 0.34
Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
+PC + PCQ+ G C Y C+C G+ G+NC
Sbjct: 1086 DPCLAQPCQHGGTCRGY-MGGYMCECL-PGYNGDNC 1119
Score = 30.0 bits (66), Expect = 6.4
Identities = 14/36 (38%), Positives = 18/36 (50%), Gaps = 2/36 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
N C S PC+N+ C+ Q+ C C GF G C
Sbjct: 433 NECLSGPCRNQATCLD-RIGQFTCIC-MAGFTGTYC 466
Score = 30.0 bits (66), Expect = 6.4
Identities = 14/34 (41%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S PC++ G C+ + D+Y C C +G G NC
Sbjct: 586 CRSQPCRHGGKCLDL-VDKYLCRCP-SGTTGVNC 617
Score = 30.0 bits (66), Expect = 6.4
Identities = 14/37 (37%), Positives = 17/37 (45%), Gaps = 2/37 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCS 55
N C +PC N G C G + C C GF G C+
Sbjct: 851 NDCDPNPCLNGGSCQD-GVGSFSCSCL-PGFAGPRCA 885
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 41.6 bits (96), Expect = 0.002
Identities = 17/36 (47%), Positives = 24/36 (66%), Gaps = 2/36 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
C S PC + GVC+ G + Y CDC ++GF+G +C T
Sbjct: 1008 CLSEPCLHDGVCID-GINHYTCDC-KSGFFGTHCET 1041
Score = 38.9 bits (89), Expect = 0.014
Identities = 15/38 (39%), Positives = 25/38 (65%), Gaps = 2/38 (5%)
Query: 18 ANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCS 55
+N C +PC+N C + + Y+C+CT +G+ G+NCS
Sbjct: 772 SNECKMNPCKNNSTCTDL-YKSYRCECT-SGWTGQNCS 807
Score = 32.3 bits (72), Expect = 1.3
Identities = 19/46 (41%), Positives = 21/46 (45%), Gaps = 7/46 (15%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTR--TGFYGE----NCSTPE 58
N C S PC N G C + C C R TG Y E NC+ PE
Sbjct: 1081 NDCTSIPCMNEGFCQKSAHG-FTCICPRGYTGAYCEKSIDNCAEPE 1125
Score = 32.3 bits (72), Expect = 1.3
Identities = 16/38 (42%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Query: 18 ANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCS 55
A+PC C N G C+ G Y C+CT TG+ G C+
Sbjct: 2611 ASPCSLMKCGNGGTCIESGTSVY-CNCT-TGWKGSFCT 2646
Score = 29.6 bits (65), Expect = 8.4
Identities = 12/36 (33%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
N C S PC+N G C+ + +++ C+C ++G C
Sbjct: 930 NECSSEPCKNNGTCVDL-TNRFFCNC-EPEYHGPFC 963
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 41.6 bits (96), Expect = 0.002
Identities = 16/36 (44%), Positives = 24/36 (66%), Gaps = 1/36 (2%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
C S PC + G+C+ G ++Y C+CT +GF G +C T
Sbjct: 266 CASQPCLHGGLCVD-GENRYSCNCTGSGFTGTHCET 300
Score = 35.8 bits (81), Expect = 0.12
Identities = 16/34 (47%), Positives = 18/34 (52%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S PCQN VC G D Y C C G+ G +C
Sbjct: 152 CASSPCQNGAVCQD-GIDGYSCFCV-PGYQGRHC 183
Score = 35.4 bits (80), Expect = 0.15
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S PCQ+RG C+++ Y+CDC R + G NC
Sbjct: 676 CESQPCQSRGRCINLWL-SYQCDCHRP-YEGPNC 707
Score = 34.7 bits (78), Expect = 0.26
Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 6/42 (14%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDC-----TRTGFYGENCS 55
N C S+PCQN G C ++ Y C C +RT + G +CS
Sbjct: 399 NECSSNPCQNGGTCENLP-GNYTCHCPFDNLSRTFYGGRDCS 439
Score = 32.0 bits (71), Expect = 1.7
Identities = 13/26 (50%), Positives = 16/26 (61%), Gaps = 1/26 (3%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDC 44
N C S+PC N GVC S +D + C C
Sbjct: 889 NSCKSNPCHNGGVCHS-RWDDFSCSC 913
Score = 30.4 bits (67), Expect = 4.9
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 2/39 (5%)
Query: 19 NPCCSHPCQNRGVCMSV-GFDQYKCDCTRTGFYGENCST 56
+PC S+PCQ C++ G + C C G+ G C T
Sbjct: 72 DPCFSNPCQGSATCVNTPGERSFLCKCP-PGYSGTICET 109
Score = 30.0 bits (66), Expect = 6.4
Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S PC N G+C + ++++C C F GE C
Sbjct: 1301 CASDPCVNGGLCQDL-LNKFQCLCD-VAFAGERC 1332
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 41.2 bits (95), Expect = 0.003
Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 2/40 (5%)
Query: 18 ANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
AN C +PC+N GVC +G D ++C C GF + CS P
Sbjct: 171 ANSCTPNPCENDGVCTDIGGD-FRCRCP-AGFIDKTCSRP 208
Score = 36.2 bits (82), Expect = 0.089
Identities = 14/34 (41%), Positives = 20/34 (58%), Gaps = 1/34 (2%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S PC N G C+S+ Y+C C G+ G++C
Sbjct: 92 CSSAPCANNGTCVSLDDGLYECSCA-PGYSGKDC 124
Score = 32.7 bits (73), Expect = 0.99
Identities = 20/65 (30%), Positives = 28/65 (43%), Gaps = 1/65 (1%)
Query: 15 SHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTV 74
S C S PCQN G C+ Y+C C + F G C L+ ++ P+ +
Sbjct: 206 SRPVTNCASSPCQNGGTCLQHTQVSYECLC-KPEFTGLTCVKKRALSPQQVTRLPSGYGL 264
Query: 75 HYILT 79
Y LT
Sbjct: 265 AYRLT 269
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 40.4 bits (93), Expect = 0.005
Identities = 19/41 (46%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 19 NPCCSH-PCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPE 58
N C SH PC N G C++ DQY+C C G+ G NC E
Sbjct: 309 NYCGSHHPCTNGGTCINAEPDQYRCTCP-DGYSGRNCEKAE 348
Score = 36.6 bits (83), Expect = 0.068
Identities = 15/40 (37%), Positives = 23/40 (57%), Gaps = 2/40 (5%)
Query: 15 SHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
+H N C PC N G+C+ G + ++C+C GF G +C
Sbjct: 749 THNTNDCNPLPCYNGGICVD-GVNWFRCECA-PGFAGPDC 786
Score = 31.6 bits (70), Expect = 2.2
Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
C PC+N G C+ D ++C C +G+ GE C T
Sbjct: 602 CLGQPCRNGGTCID-EVDAFRCFCP-SGWEGELCDT 635
Score = 31.2 bits (69), Expect = 2.9
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 2/41 (4%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEF 59
N C PC +RG C + D Y C C G+ G+ C + EF
Sbjct: 638 NDCLPDPCHSRGRCYDLVNDFY-CACD-DGWKGKTCHSREF 676
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 40.4 bits (93), Expect = 0.005
Identities = 19/41 (46%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 19 NPCCSH-PCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPE 58
N C SH PC N G C++ DQY+C C G+ G NC E
Sbjct: 309 NYCGSHHPCTNGGTCINAEPDQYRCTCP-DGYSGRNCEKAE 348
Score = 36.6 bits (83), Expect = 0.068
Identities = 15/40 (37%), Positives = 23/40 (57%), Gaps = 2/40 (5%)
Query: 15 SHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
+H N C PC N G+C+ G + ++C+C GF G +C
Sbjct: 787 THNTNDCNPLPCYNGGICVD-GVNWFRCECA-PGFAGPDC 824
Score = 31.6 bits (70), Expect = 2.2
Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
C PC+N G C+ D ++C C +G+ GE C T
Sbjct: 640 CLGQPCRNGGTCID-EVDAFRCFCP-SGWEGELCDT 673
Score = 31.2 bits (69), Expect = 2.9
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 2/41 (4%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEF 59
N C PC +RG C + D Y C C G+ G+ C + EF
Sbjct: 676 NDCLPDPCHSRGRCYDLVNDFY-CACD-DGWKGKTCHSREF 714
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 39.7 bits (91), Expect = 0.008
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 19 NPCCSH-PCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPE 58
N C +H PC N G C + G D+Y+C C G+ G NC E
Sbjct: 298 NYCGTHQPCLNGGTCSNTGPDKYQCSCPE-GYSGPNCEIAE 337
Score = 38.5 bits (88), Expect = 0.018
Identities = 16/40 (40%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 15 SHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
+ N C HPC N G C+ G + Y+C+C GF G +C
Sbjct: 780 AQNTNDCSPHPCYNSGTCVD-GDNWYRCECA-PGFAGPDC 817
Score = 37.4 bits (85), Expect = 0.040
Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 3/71 (4%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTH 80
C HPC G C S K CT +Y +NC+ F T K + P T H I +
Sbjct: 925 CFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITF-TFNKEMMSPGLTTEH-ICSE 982
Query: 81 FKGFWNVVNNI 91
+ N++ N+
Sbjct: 983 LRNL-NILKNV 992
Score = 36.6 bits (83), Expect = 0.068
Identities = 17/38 (44%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
N C S+PC+N G C+ G + YKC C+ G+ G C T
Sbjct: 631 NDCESNPCRNGGTCID-GVNSYKCICS-DGWEGAYCET 666
Score = 34.7 bits (78), Expect = 0.26
Identities = 18/38 (47%), Positives = 23/38 (60%), Gaps = 6/38 (15%)
Query: 21 CCSHPCQNRGVC--MSVGFDQYKCDCTRTGFYGENCST 56
C S PC NRG C S+GF+ C+C+ G+ G CST
Sbjct: 340 CLSDPCHNRGSCKETSLGFE---CECS-PGWTGPTCST 373
Score = 33.9 bits (76), Expect = 0.44
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
N C +PC N G C + D Y CDC + G+ G+ C
Sbjct: 669 NDCSQNPCHNGGTCRDLVNDFY-CDC-KNGWKGKTC 702
Score = 29.6 bits (65), Expect = 8.4
Identities = 14/34 (41%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S+PC N G C + ++++C C TGF G C
Sbjct: 491 CASNPCLNGGHCQN-EINRFQCLCP-TGFSGNLC 522
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 39.7 bits (91), Expect = 0.008
Identities = 20/42 (47%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 19 NPCCSHPCQNRGVCMSV---GFDQYKCDCTRTGFYGENCSTP 57
NPC S PC+N G C V G Y C C GF G C TP
Sbjct: 61 NPCLSTPCKNAGTCHVVDRRGVADYACSCA-LGFSGPLCLTP 101
Score = 39.3 bits (90), Expect = 0.011
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 2/40 (5%)
Query: 15 SHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
S + C SHPCQN G C+ + + YKC C R G G +C
Sbjct: 1181 SEEIDECLSHPCQNGGTCLDLP-NTYKCSCPR-GTQGVHC 1218
Score = 38.5 bits (88), Expect = 0.018
Identities = 16/35 (45%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 20 PCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
PC PCQN G C G ++C C GF G+NC
Sbjct: 221 PCSPSPCQNGGTCRPTGDVTHECACL-PGFTGQNC 254
Score = 38.1 bits (87), Expect = 0.023
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 5 ALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
AL L L+ N C ++PC+N G C + +YKC C G+ G++C
Sbjct: 90 ALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCP-PGWSGKSC 138
Score = 36.2 bits (82), Expect = 0.089
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 2/39 (5%)
Query: 16 HTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
H N C S PC + G C G Y+C C + G+ G NC
Sbjct: 1020 HDVNECDSQPCLHGGTCQD-GCGSYRCTCPQ-GYTGPNC 1056
Score = 35.8 bits (81), Expect = 0.12
Identities = 18/38 (47%), Positives = 20/38 (52%), Gaps = 2/38 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCST 56
N C S+PC N G C + Y C C R GF G NC T
Sbjct: 755 NECESNPCVNGGTCKDM-TSGYVCTC-REGFSGPNCQT 790
Score = 33.5 bits (75), Expect = 0.58
Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 20 PCCSHPCQNRGVC-MSVGFDQYKCDCTRTGFYGENC 54
PC PC+N G C S ++ + C C TG+ G+ C
Sbjct: 832 PCAPSPCRNGGECRQSEDYESFSCVCP-TGWQGQTC 866
Score = 32.3 bits (72), Expect = 1.3
Identities = 15/37 (40%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTP 57
C S PC+N G C QY+C+C +G+ G C P
Sbjct: 1063 CDSSPCKNGGKCWQT-HTQYRCECP-SGWTGLYCDVP 1097
Score = 32.0 bits (71), Expect = 1.7
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 2/37 (5%)
Query: 18 ANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
A+PC S+PC N G C+ Y C C F+G C
Sbjct: 141 ADPCASNPCANGGQCLPFE-ASYICHCP-PSFHGPTC 175
Score = 31.6 bits (70), Expect = 2.2
Identities = 17/42 (40%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC--STPE 58
N C S PC+N C D Y C C GF G +C +TP+
Sbjct: 947 NECASDPCRNGANCTDC-VDSYTCTCP-AGFSGIHCENNTPD 986
Score = 31.2 bits (69), Expect = 2.9
Identities = 12/26 (46%), Positives = 16/26 (61%), Gaps = 1/26 (3%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDC 44
N C S+PC N+G C+ YKC+C
Sbjct: 793 NECASNPCLNQGTCID-DVAGYKCNC 817
Score = 30.8 bits (68), Expect = 3.8
Identities = 13/34 (38%), Positives = 20/34 (58%), Gaps = 2/34 (5%)
Query: 21 CCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
C S PC + G C+ ++++C+C TGF G C
Sbjct: 494 CASSPCLHNGRCLD-KINEFQCECP-TGFTGHLC 525
Score = 30.8 bits (68), Expect = 3.8
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 2/39 (5%)
Query: 16 HTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
+ + C S PC+N C+ G + Y C CT G+ G +C
Sbjct: 527 YDVDECASTPCKNGAKCLD-GPNTYTCVCTE-GYTGTHC 563
Score = 30.4 bits (67), Expect = 4.9
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 19 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENC 54
N C S+PCQN C+ +++C C G+ G +C
Sbjct: 454 NECVSNPCQNDATCLD-QIGEFQCIC-MPGYEGVHC 487
>gi|38348304 von Willebrand factor A domain containing 2 [Homo
sapiens]
Length = 725
Score = 39.7 bits (91), Expect = 0.008
Identities = 19/37 (51%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 20 PCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGE-NCS 55
PC S PCQN G C+ G D Y+C C F GE NC+
Sbjct: 298 PCDSQPCQNGGTCVPEGLDGYQCLCP-LAFGGEANCA 333
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,418,573
Number of Sequences: 37866
Number of extensions: 1149478
Number of successful extensions: 2754
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 2474
Number of HSP's gapped (non-prelim): 328
length of query: 604
length of database: 18,247,518
effective HSP length: 108
effective length of query: 496
effective length of database: 14,157,990
effective search space: 7022363040
effective search space used: 7022363040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.