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Search of human proteins with 4506063
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506063 cAMP-dependent protein kinase, regulatory subunit
alpha 1 [Homo sapiens]
(381 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47132583 cAMP-dependent protein kinase, regulatory subunit al... 750 0.0
gi|47132581 cAMP-dependent protein kinase, regulatory subunit al... 750 0.0
gi|4506063 cAMP-dependent protein kinase, regulatory subunit alp... 750 0.0
gi|38257139 protein kinase, cAMP-dependent, regulatory, type I, ... 630 0.0
gi|4758958 cAMP-dependent protein kinase, regulatory subunit alp... 237 1e-62
gi|47132585 cAMP-dependent protein kinase, regulatory subunit be... 234 1e-61
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 167 1e-41
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 163 3e-40
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 147 2e-35
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 54 2e-07
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 54 2e-07
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 54 2e-07
gi|148727335 patatin-like phospholipase domain containing 7 isof... 54 2e-07
gi|148727290 patatin-like phospholipase domain containing 7 isof... 54 2e-07
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 54 3e-07
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 54 3e-07
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 52 7e-07
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 49 6e-06
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 49 6e-06
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 49 1e-05
gi|116256487 patatin-like phospholipase domain containing 6 [Hom... 48 1e-05
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 42 0.001
gi|18201890 hypothetical protein LOC140894 [Homo sapiens] 40 0.005
gi|123173766 tubulin polyglutamylase complex subunit 1 [Homo sap... 39 0.008
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 39 0.010
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 38 0.013
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 38 0.013
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 36 0.050
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 36 0.066
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 36 0.066
>gi|47132583 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 750 bits (1936), Expect = 0.0
Identities = 381/381 (100%), Positives = 381/381 (100%)
Query: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
Query: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSDILKRNIQQYNSFVSLSV 381
PCSDILKRNIQQYNSFVSLSV
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381
>gi|47132581 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 750 bits (1936), Expect = 0.0
Identities = 381/381 (100%), Positives = 381/381 (100%)
Query: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
Query: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSDILKRNIQQYNSFVSLSV 381
PCSDILKRNIQQYNSFVSLSV
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381
>gi|4506063 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 750 bits (1936), Expect = 0.0
Identities = 381/381 (100%), Positives = 381/381 (100%)
Query: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
Query: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSDILKRNIQQYNSFVSLSV 381
PCSDILKRNIQQYNSFVSLSV
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381
>gi|38257139 protein kinase, cAMP-dependent, regulatory, type I,
beta [Homo sapiens]
Length = 381
Score = 630 bits (1625), Expect = 0.0
Identities = 310/381 (81%), Positives = 345/381 (90%)
Query: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
M S SEE SL+ CELYVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKE
Sbjct: 1 MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE 60
Query: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
E +QI QK+ +++DS ++E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPK
Sbjct: 61 ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK 120
Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
DYKTM ALAKAI KNVLF+HLDDNERSDIFDAMF V+ IAGETVIQQG+EGDNFYV+DQG
Sbjct: 121 DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180
Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
E DVYVN EW T++ EGGSFGELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTL
Sbjct: 181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
RKRKMYEEFLSKVSILESL+KWERLTVADALEPVQFEDG+KIVVQGEPGD+F+II EG+A
Sbjct: 241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300
Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
+VLQRRS NEE+VEVGRLGPSDYFGEIALL+NRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSDILKRNIQQYNSFVSLSV 381
PCS+ILKRNIQ+YNSF+SL+V
Sbjct: 361 PCSEILKRNIQRYNSFISLTV 381
>gi|4758958 cAMP-dependent protein kinase, regulatory subunit alpha
2 [Homo sapiens]
Length = 404
Score = 237 bits (604), Expect = 1e-62
Identities = 144/375 (38%), Positives = 209/375 (55%), Gaps = 33/375 (8%)
Query: 30 LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPN- 88
LL+ V++ +P + F EYF RL EA+ ++ A T S P P+
Sbjct: 13 LLQGYTVEVLRQQPPDLVEFAVEYFTRLR--EARAPASVLPAATPRQSLGHPPPEPGPDR 70
Query: 89 ------------------PVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAAL 128
PV RR ++ AE Y EE+ + R + PK + L
Sbjct: 71 VADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRL 130
Query: 129 AKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNN 188
+A + +LF +LD + S + DAMF A E VI QGD+GDNFYVI++G D+ V
Sbjct: 131 QEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTK 190
Query: 189 EWAT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 244
+ T SVG+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KRK
Sbjct: 191 DNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK 250
Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
M+E F+ V +L+SL+ ER+ + D + ++DG++I+ QGE D F+II G ++L
Sbjct: 251 MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILI 310
Query: 305 R------RSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
R + + VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 311 RSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERL 370
Query: 359 LGPCSDILKRNIQQY 373
LGPC DI+KRNI Y
Sbjct: 371 LGPCMDIMKRNISHY 385
>gi|47132585 cAMP-dependent protein kinase, regulatory subunit beta
2 [Homo sapiens]
Length = 418
Score = 234 bits (596), Expect = 1e-61
Identities = 134/315 (42%), Positives = 185/315 (58%), Gaps = 19/315 (6%)
Query: 76 DSREDEISPPPPN----PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAA 127
D E+E +P PV+ RR ++ AE Y E+DA S R + PK
Sbjct: 87 DGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNR 144
Query: 128 LAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVN 187
L +A + +LF +LD + S + DAMF GE VI QGD+GDNFYVID+G D+YV
Sbjct: 145 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVK 204
Query: 188 ----NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
+ GSFGELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KR
Sbjct: 205 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKR 264
Query: 244 KMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVL 303
KMYE F+ + L+SL+ ERL V D + + DG++I+ QG+ D FFI+ G +
Sbjct: 265 KMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKIT 324
Query: 304 QRR---SENEE--FVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
+R SE EE VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+
Sbjct: 325 MKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 384
Query: 359 LGPCSDILKRNIQQY 373
LGPC +I+KRNI Y
Sbjct: 385 LGPCMEIMKRNIATY 399
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 167 bits (424), Expect = 1e-41
Identities = 107/361 (29%), Positives = 178/361 (49%), Gaps = 26/361 (7%)
Query: 7 AASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQ 66
A E+ LR+ + + + ++ KD ++Q ++ + +R ++ +K+ A +Q
Sbjct: 10 ALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQ 69
Query: 67 NLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAE--VYTEEDAASYVRKVIPKDYKT 124
+ R +R AISAE + +D + PK ++
Sbjct: 70 G------------------------EPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQS 105
Query: 125 MAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDV 184
+ +AI N +L+ ++ +I D M+ V + +I++GD G YV++ G+ +V
Sbjct: 106 KDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEV 165
Query: 185 YVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 244
++G G FGELA++Y R ATVK NVKLW IDR ++ I+M + L K
Sbjct: 166 TKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHT 225
Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
Y EFL V +SL + +AD LE +E+G+ I+ QG GD FFII +G+ V +
Sbjct: 226 EYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTR 285
Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSD 364
S +E+ V + LG D+FGE AL R A V+A + C+ +DR F+ ++G D
Sbjct: 286 EDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDD 345
Query: 365 I 365
+
Sbjct: 346 V 346
Score = 54.3 bits (129), Expect = 2e-07
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 138 FSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE------WA 191
F L + S + D + + GE +I+QG GD F++I +G +V + +
Sbjct: 237 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFL 296
Query: 192 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
++G+G FGE AL R A V A V IDRDS++ ++ G K YE+ +
Sbjct: 297 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 356
Query: 252 K 252
K
Sbjct: 357 K 357
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 163 bits (412), Expect = 3e-40
Identities = 109/338 (32%), Positives = 174/338 (51%), Gaps = 13/338 (3%)
Query: 31 LKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV 90
L++ ++ + ER ++E +RL ++E ++IQ L++ + S + P P +
Sbjct: 4 LEEDFAKILMLKEER----IKELEKRLSEKE-EEIQELKRKLHKCQS----VLPVPSTHI 54
Query: 91 VKGRRRRGAISAEVYTEE---DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERS 147
R ISAE T D RK K ++ + +AI N +L+ ++
Sbjct: 55 GPRTTRAQGISAEPQTYRSFHDLRQAFRK-FTKSERSKDLIKEAILDNDFMKNLELSQIQ 113
Query: 148 DIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIY 207
+I D M+ V + +I++GD G YV++ G+ +V ++G G FGELA++Y
Sbjct: 114 EIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILY 173
Query: 208 GTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTV 267
R ATVK NVKLW IDR ++ I+M + L K Y EFL V +SL + +
Sbjct: 174 NCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKL 233
Query: 268 ADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEI 327
AD LE +E+G+ I+ QG GD FFII +G+ V + S +E+ V + LG D+FGE
Sbjct: 234 ADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEK 293
Query: 328 ALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDI 365
AL R A V+A + C+ +DR F+ ++G D+
Sbjct: 294 ALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDV 331
Score = 54.3 bits (129), Expect = 2e-07
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 138 FSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE------WA 191
F L + S + D + + GE +I+QG GD F++I +G +V + +
Sbjct: 222 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFL 281
Query: 192 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
++G+G FGE AL R A V A V IDRDS++ ++ G K YE+ +
Sbjct: 282 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 341
Query: 252 K 252
K
Sbjct: 342 K 342
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 147 bits (370), Expect = 2e-35
Identities = 83/282 (29%), Positives = 150/282 (53%), Gaps = 10/282 (3%)
Query: 96 RRGA---ISAEVYT------EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNER 146
RRGA +SAE T + S+ + + KD + A+ KN LD +
Sbjct: 118 RRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQI 177
Query: 147 SDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALI 206
D+ + M+ ++ G +I+QG+ G++ +V+ +G +V+ + +S+ +FGELA++
Sbjct: 178 KDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAIL 237
Query: 207 YGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLT 266
Y R A+VKA TNVK W +DR+ ++ I+ + + + Y FL VS+L++L + +
Sbjct: 238 YNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTK 297
Query: 267 VADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGE 326
+ D LE ++ G I+ +GE G FFI+ +G V Q +++ + L +YFGE
Sbjct: 298 IIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGE 357
Query: 327 IALLMNRPRAATVVA-RGPLKCVKLDRPRFERVLGPCSDILK 367
AL+ + R+A ++A + C+ +DR F + +G ++ K
Sbjct: 358 KALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQK 399
Score = 54.7 bits (130), Expect = 1e-07
Identities = 41/168 (24%), Positives = 82/168 (48%), Gaps = 12/168 (7%)
Query: 213 ATVKAKTNVKLWGIDRD---SYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVAD 269
A V A+ + + +++ S+ + + ++K+ + L+K L+ LD + + +
Sbjct: 123 AGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVE 182
Query: 270 ALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIAL 329
+ ++ G I+ QGEPG+ F++ EG V Q E+ + + + FGE+A+
Sbjct: 183 CMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQ----GEKLLSSIPMWTT--FGELAI 236
Query: 330 LMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFV 377
L N R A+V A +K LDR F+ ++ + + +QY +F+
Sbjct: 237 LYNCTRTASVKAITNVKTWALDREVFQNIMRRTA---QARDEQYRNFL 281
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 4/122 (3%)
Query: 139 SHLDDNERSDIFDAM-FSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEW-ATSVGE 196
+HL ++ + ++ + F AG + QGD+G ++Y+I +G +V + + T++ E
Sbjct: 205 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 264
Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
G FG+LAL+ PRAAT + + N +D+ + RI+ + ++ EE V +
Sbjct: 265 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 323
Query: 256 LE 257
LE
Sbjct: 324 LE 325
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
++EE L ++ + +R A L + G + QG+ G ++II +GS V+
Sbjct: 194 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 253
Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAAT++ R +++D+ F R++
Sbjct: 254 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 304
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 4/122 (3%)
Query: 139 SHLDDNERSDIFDAM-FSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEW-ATSVGE 196
+HL ++ + ++ + F AG + QGD+G ++Y+I +G +V + + T++ E
Sbjct: 205 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 264
Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
G FG+LAL+ PRAAT + + N +D+ + RI+ + ++ EE V +
Sbjct: 265 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 323
Query: 256 LE 257
LE
Sbjct: 324 LE 325
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
++EE L ++ + +R A L + G + QG+ G ++II +GS V+
Sbjct: 194 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 253
Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAAT++ R +++D+ F R++
Sbjct: 254 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 304
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 4/122 (3%)
Query: 139 SHLDDNERSDIFDAM-FSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEW-ATSVGE 196
+HL ++ + ++ + F AG + QGD+G ++Y+I +G +V + + T++ E
Sbjct: 247 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 306
Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
G FG+LAL+ PRAAT + + N +D+ + RI+ + ++ EE V +
Sbjct: 307 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 365
Query: 256 LE 257
LE
Sbjct: 366 LE 367
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
++EE L ++ + +R A L + G + QG+ G ++II +GS V+
Sbjct: 236 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 295
Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAAT++ R +++D+ F R++
Sbjct: 296 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 346
>gi|148727335 patatin-like phospholipase domain containing 7 isoform
a [Homo sapiens]
Length = 1342
Score = 53.9 bits (128), Expect = 2e-07
Identities = 66/274 (24%), Positives = 123/274 (44%), Gaps = 23/274 (8%)
Query: 87 PNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAIEKNVL-FSHLDD 143
P V + R+ + AE+ + + + S+ + + + A+ +A +K++L L+D
Sbjct: 435 PGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLAS--RKSDAIFRAAKKDLLTLMKLED 492
Query: 144 NERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVY---VNNEWATSV---GEG 197
+ D A+ V AG V +QGD+ + + G VY + ++ T + G
Sbjct: 493 SSLLDGRVALLHVP--AGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPG 550
Query: 198 GSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV-SIL 256
G+LA++ G P TVKA + I + + I+ RK L +++
Sbjct: 551 EMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIM-------RKQPTVVLGVAHTVV 603
Query: 257 ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVG 316
+ + + R + AL+ V+ E G+ I QG+ D +I+L G + R+ + ++ + G
Sbjct: 604 KRMSSFVR-QIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRL-AG 661
Query: 317 RLGPSDYFGEIALLMNRPRAATVVARGPLKCVKL 350
G D G + L ++ RA TV A + KL
Sbjct: 662 EYGRGDLVGVVETLTHQARATTVHAVRDSELAKL 695
Score = 31.6 bits (70), Expect = 1.2
Identities = 27/122 (22%), Positives = 50/122 (40%), Gaps = 1/122 (0%)
Query: 239 TLRKRKMYEEFLSKVSILESLDKWERLTVADA-LEPVQFEDGQKIVVQGEPGDEFFIILE 297
TL RK F + L +L K E ++ D + + G + QG+ ++
Sbjct: 467 TLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVS 526
Query: 298 GSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFER 357
G V QR+ ++E + P + G++A+L P TV A + + + F
Sbjct: 527 GLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYE 586
Query: 358 VL 359
++
Sbjct: 587 IM 588
>gi|148727290 patatin-like phospholipase domain containing 7 isoform
b [Homo sapiens]
Length = 1317
Score = 53.9 bits (128), Expect = 2e-07
Identities = 66/274 (24%), Positives = 123/274 (44%), Gaps = 23/274 (8%)
Query: 87 PNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAIEKNVL-FSHLDD 143
P V + R+ + AE+ + + + S+ + + + A+ +A +K++L L+D
Sbjct: 410 PGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLAS--RKSDAIFRAAKKDLLTLMKLED 467
Query: 144 NERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVY---VNNEWATSV---GEG 197
+ D A+ V AG V +QGD+ + + G VY + ++ T + G
Sbjct: 468 SSLLDGRVALLHVP--AGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPG 525
Query: 198 GSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV-SIL 256
G+LA++ G P TVKA + I + + I+ RK L +++
Sbjct: 526 EMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIM-------RKQPTVVLGVAHTVV 578
Query: 257 ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVG 316
+ + + R + AL+ V+ E G+ I QG+ D +I+L G + R+ + ++ + G
Sbjct: 579 KRMSSFVR-QIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRL-AG 636
Query: 317 RLGPSDYFGEIALLMNRPRAATVVARGPLKCVKL 350
G D G + L ++ RA TV A + KL
Sbjct: 637 EYGRGDLVGVVETLTHQARATTVHAVRDSELAKL 670
Score = 31.6 bits (70), Expect = 1.2
Identities = 27/122 (22%), Positives = 50/122 (40%), Gaps = 1/122 (0%)
Query: 239 TLRKRKMYEEFLSKVSILESLDKWERLTVADA-LEPVQFEDGQKIVVQGEPGDEFFIILE 297
TL RK F + L +L K E ++ D + + G + QG+ ++
Sbjct: 442 TLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVS 501
Query: 298 GSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFER 357
G V QR+ ++E + P + G++A+L P TV A + + + F
Sbjct: 502 GLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYE 561
Query: 358 VL 359
++
Sbjct: 562 IM 563
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/143 (27%), Positives = 73/143 (51%), Gaps = 10/143 (6%)
Query: 139 SHLDDNERSDIFDAMFSVSFIAGETVI-QQGDEGDNFYVIDQGETDVYVNNEWAT-SVGE 196
SHL + ++ + S G TV+ QG+EG ++Y+I +G +V + + ++ E
Sbjct: 214 SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE 273
Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILM---GSTLRKRKMYEEFLSK 252
G FG+LAL+ PRAA+ V + N +D++ + RIL +T+R ++ ++ L
Sbjct: 274 GDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL-- 331
Query: 253 VSILESLDKWERLTVADALEPVQ 275
+LE + R + +P Q
Sbjct: 332 --VLEKVPAGNRASNQGNSQPQQ 352
Score = 39.7 bits (91), Expect = 0.005
Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVV-QGEPGDEFFIILEGSAAVL 303
+YEE L + L L + +A L G ++ QGE G ++IIL+GS V+
Sbjct: 203 IYEELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 261
Query: 304 QRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAA++V R +++D+ F R+L
Sbjct: 262 IYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 313
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/143 (27%), Positives = 73/143 (51%), Gaps = 10/143 (6%)
Query: 139 SHLDDNERSDIFDAMFSVSFIAGETVI-QQGDEGDNFYVIDQGETDVYVNNEWAT-SVGE 196
SHL + ++ + S G TV+ QG+EG ++Y+I +G +V + + ++ E
Sbjct: 358 SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE 417
Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILM---GSTLRKRKMYEEFLSK 252
G FG+LAL+ PRAA+ V + N +D++ + RIL +T+R ++ ++ L
Sbjct: 418 GDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL-- 475
Query: 253 VSILESLDKWERLTVADALEPVQ 275
+LE + R + +P Q
Sbjct: 476 --VLEKVPAGNRASNQGNSQPQQ 496
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/81 (30%), Positives = 45/81 (55%), Gaps = 2/81 (2%)
Query: 277 EDGQKIVVQGEPGDEFFIILEGSAAV-LQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
E G + QG+ G ++ +L GS V + S +++ V + LG FGE ++L N PR
Sbjct: 65 EKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPR 123
Query: 336 AATVVARGPLKCVKLDRPRFE 356
AT+V R + +++++ F+
Sbjct: 124 HATIVTRESSELLRIEQKDFK 144
Score = 40.0 bits (92), Expect = 0.003
Identities = 24/81 (29%), Positives = 45/81 (55%), Gaps = 8/81 (9%)
Query: 161 GETVIQQGDEGDNFYVIDQGETDVYVNNEWA-------TSVGEGGSFGELALIYGTPRAA 213
G T+ +QGD G N+Y + G DV V+ + ++G G +FGE +++ TPR A
Sbjct: 67 GITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHA 125
Query: 214 TVKAKTNVKLWGIDRDSYRRI 234
T+ + + +L I++ ++ +
Sbjct: 126 TIVTRESSELLRIEQKDFKAL 146
Score = 39.7 bits (91), Expect = 0.005
Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVV-QGEPGDEFFIILEGSAAVL 303
+YEE L + L L + +A L G ++ QGE G ++IIL+GS V+
Sbjct: 347 IYEELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 405
Query: 304 QRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAA++V R +++D+ F R+L
Sbjct: 406 IYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 52.4 bits (124), Expect = 7e-07
Identities = 29/114 (25%), Positives = 53/114 (46%)
Query: 130 KAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE 189
K + LF++ D N + + + F G+ +I++G G Y I G V
Sbjct: 588 KLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGN 647
Query: 190 WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
T + +G FGE+ L+ R A+V+A T +L+ + D++ +L + +R
Sbjct: 648 KETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 701
Score = 36.6 bits (83), Expect = 0.039
Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 6/84 (7%)
Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
F+ G I+ +G G + + I G +VL + ++ +L YFGEI LL R
Sbjct: 616 FQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKET------KLADGSYFGEICLLTRGRR 669
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 670 TASVRADTYCRLYSLSVDNFNEVL 693
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 49.3 bits (116), Expect = 6e-06
Identities = 28/114 (24%), Positives = 52/114 (45%)
Query: 130 KAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE 189
K + LF++ D N + + + F G+ +I++G G Y I G V
Sbjct: 537 KLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGN 596
Query: 190 WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
+ +G FGE+ L+ R A+V+A T +L+ + D++ +L + +R
Sbjct: 597 KEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 650
Score = 36.6 bits (83), Expect = 0.039
Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 6/84 (7%)
Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
F+ G I+ +G G + + I G +VL + N+E +L YFGEI LL R
Sbjct: 565 FQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEM----KLSDGSYFGEICLLTRGRR 618
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 619 TASVRADTYCRLYSLSVDNFNEVL 642
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 49.3 bits (116), Expect = 6e-06
Identities = 28/107 (26%), Positives = 50/107 (46%)
Query: 137 LFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGE 196
LF+H D + + + + F G+ V+++G G Y I G V T + +
Sbjct: 428 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTD 487
Query: 197 GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
G FGE+ L+ R A+V+A T +L+ + D + +L + +R
Sbjct: 488 GSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRR 534
Score = 37.7 bits (86), Expect = 0.017
Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 6/84 (7%)
Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
F+ G +V +G G + + I G +VL R + + RL YFGEI LL R
Sbjct: 449 FQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDT------RLTDGSYFGEICLLTRGRR 502
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 503 TASVRADTYCRLYSLSVDHFNAVL 526
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 48.5 bits (114), Expect = 1e-05
Identities = 28/114 (24%), Positives = 53/114 (46%)
Query: 130 KAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE 189
K + LF++ D N + + + F G+ +I++G G Y I G V +
Sbjct: 468 KLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSS 527
Query: 190 WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
+ +G FGE+ L+ R A+V+A T +L+ + D++ +L + +R
Sbjct: 528 KEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 581
Score = 37.7 bits (86), Expect = 0.017
Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 6/84 (7%)
Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
F+ G I+ +G G + + I G A V+ + S+ + + YFGEI LL R
Sbjct: 496 FQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTD------GSYFGEICLLTKGRR 549
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 550 TASVRADTYCRLYSLSVDNFNEVL 573
>gi|116256487 patatin-like phospholipase domain containing 6 [Homo
sapiens]
Length = 1327
Score = 48.1 bits (113), Expect = 1e-05
Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 18/199 (9%)
Query: 160 AGETVIQQGDEGDNFYVIDQGETDVYVN-----NEWATSVGEGGSF-GELALIYGTPRAA 213
AG + +QGD+ + + + G VY + V + G G+LA++ G P
Sbjct: 487 AGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIF 546
Query: 214 TVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVS-ILESLDKWERLTVADALE 272
T++A+ + I + + I+ +++S + +D A++
Sbjct: 547 TLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMD--------FAID 598
Query: 273 PVQFEDGQKIVVQGEPGDEFFIILEGS-AAVLQRRSENEEFVEVGRLGPSDYFGEIALLM 331
E G+ + QG+ D +I+L G +V+QR S +E VG G D G + L
Sbjct: 599 WTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL--VGEYGRGDLIGVVEALT 656
Query: 332 NRPRAATVVARGPLKCVKL 350
+PRA TV A + KL
Sbjct: 657 RQPRATTVHAVRDTELAKL 675
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 41.6 bits (96), Expect = 0.001
Identities = 36/130 (27%), Positives = 57/130 (43%), Gaps = 13/130 (10%)
Query: 120 KDYKTMAALAKAIEKNV-------LFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGD 172
K T LA AI+ N LF D D+ + SV ++ G+ V ++G+ G
Sbjct: 500 KTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGK 559
Query: 173 NFYVIDQGETDVYVNNEWA---TSVGEGGSFGELALIY---GTPRAATVKAKTNVKLWGI 226
Y+I GE V + ++ G FGE++L+ G R A V A L +
Sbjct: 560 EMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTL 619
Query: 227 DRDSYRRILM 236
D+ + + IL+
Sbjct: 620 DKKTLQEILV 629
Score = 39.3 bits (90), Expect = 0.006
Identities = 33/113 (29%), Positives = 48/113 (42%), Gaps = 6/113 (5%)
Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
+SKV + + D + L+ V + G + +GE G E +II G VL
Sbjct: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578
Query: 310 EEFVEVGRLGPSDYFGEIALLM---NRPRAATVVARGPLKCVKLDRPRFERVL 359
+ V L FGEI+LL R A VVA G + LD+ + +L
Sbjct: 579 KVLV---TLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628
>gi|18201890 hypothetical protein LOC140894 [Homo sapiens]
Length = 572
Score = 39.7 bits (91), Expect = 0.005
Identities = 33/151 (21%), Positives = 69/151 (45%), Gaps = 11/151 (7%)
Query: 164 VIQQGDEGDNFYVIDQGETDVYVNNEWATS--------VGEGGSFGELALIYGTPRAATV 215
+I++G +G++FY I G + + + +++ + +G FGE+ +++ + R +T+
Sbjct: 143 IIKKGQKGNSFYFIYLGTVAITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTI 202
Query: 216 KAKTNVKLWGIDRDSYRRILMGSTLRKRKMYE-EFLSKVSILESLDKWERLTVADALEPV 274
+ +DR+ + + ++K Y EF K+ + S E+L A+ +
Sbjct: 203 VCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMELFASWSD-EKLWQLVAMAKI 261
Query: 275 Q-FEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
+ F GQ I I +GS VL+
Sbjct: 262 ERFSYGQLISKDFGESPFIMFISKGSCEVLR 292
>gi|123173766 tubulin polyglutamylase complex subunit 1 [Homo
sapiens]
Length = 290
Score = 38.9 bits (89), Expect = 0.008
Identities = 17/56 (30%), Positives = 34/56 (60%)
Query: 2 ESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERL 57
+SG + S A + E ++++ + +L+ +++++ ARPE P+AFL YFE +
Sbjct: 19 DSGRQSVSRAAGAAESEEDFLRQVGVTEMLRAALLKVLEARPEEPIAFLAHYFENM 74
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 38.5 bits (88), Expect = 0.010
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
LS+V I ++ + + L+P + G+ + +G+ G E +II EG AV+ +
Sbjct: 343 LSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVV----AD 398
Query: 310 EEFVEVGRLGPSDYFGEIALL 330
+ + LG YFGEI+++
Sbjct: 399 DGITQYAVLGAGLYFGEISII 419
Score = 36.2 bits (82), Expect = 0.050
Identities = 32/129 (24%), Positives = 63/129 (48%), Gaps = 15/129 (11%)
Query: 157 SFIAGETVIQQGDEGDNFYVIDQGETDVYVNN---EWATSVGEGGSFGELALI------Y 207
++ GE V ++GD G Y+I +G+ V ++ ++A +G G FGE+++I
Sbjct: 368 TYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAV-LGAGLYFGEISIINIKGNMS 426
Query: 208 GTPRAATVKAKTNVKLWGIDRDSYRRIL----MGSTLRKRKMYEEFLSKVSILESLDKWE 263
G R A +K+ L+ + ++ R +L T+ + K E L K++ L+ +
Sbjct: 427 GNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEK-GREILLKMNKLDVNAEAA 485
Query: 264 RLTVADALE 272
+ + +A E
Sbjct: 486 EIALQEATE 494
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 38.1 bits (87), Expect = 0.013
Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
L KV I + + + + L P F G I +G+ G E +II EG AV+
Sbjct: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
Query: 310 EEFVEVGRLGPSDYFGEIALL 330
+ V L YFGEI++L
Sbjct: 519 QFVV----LSDGSYFGEISIL 535
Score = 32.0 bits (71), Expect = 0.95
Identities = 22/99 (22%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 158 FIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGT 209
F G+ + ++GD G Y+I++G+ V ++ V +G FGE++++ G
Sbjct: 485 FSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGN 544
Query: 210 PRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEE 248
R A +++ L+ + +D L K+ + E+
Sbjct: 545 RRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEK 583
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 38.1 bits (87), Expect = 0.013
Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
L KV I + + + + L P F G I +G+ G E +II EG AV+
Sbjct: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536
Query: 310 EEFVEVGRLGPSDYFGEIALL 330
+ V L YFGEI++L
Sbjct: 537 QFVV----LSDGSYFGEISIL 553
Score = 32.0 bits (71), Expect = 0.95
Identities = 22/99 (22%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 158 FIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGT 209
F G+ + ++GD G Y+I++G+ V ++ V +G FGE++++ G
Sbjct: 503 FSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGN 562
Query: 210 PRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEE 248
R A +++ L+ + +D L K+ + E+
Sbjct: 563 RRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEK 601
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 36.2 bits (82), Expect = 0.050
Identities = 32/113 (28%), Positives = 45/113 (39%), Gaps = 6/113 (5%)
Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
+SKV++ + D+ + L V + + +GE G E +II G VL
Sbjct: 957 VSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGK 1016
Query: 310 EEFVEVGRLGPSDYFGEIALLM---NRPRAATVVARGPLKCVKLDRPRFERVL 359
V L FGEI+LL R A VVA G LD+ +L
Sbjct: 1017 SVLV---TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEIL 1066
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 35.8 bits (81), Expect = 0.066
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
L KV I + + + L+P + G I +G+ G E +II EG AV+
Sbjct: 543 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 602
Query: 310 EEFVEVGRLGPSDYFGEIALL 330
+ V L YFGEI++L
Sbjct: 603 QFVV----LSDGSYFGEISIL 619
Score = 30.0 bits (66), Expect = 3.6
Identities = 20/83 (24%), Positives = 39/83 (46%), Gaps = 8/83 (9%)
Query: 161 GETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGTPRA 212
G+ + ++GD G Y+I +G+ V ++ V +G FGE++++ G R
Sbjct: 572 GDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRT 631
Query: 213 ATVKAKTNVKLWGIDRDSYRRIL 235
A +K+ L+ + +D L
Sbjct: 632 ANIKSIGYSDLFCLSKDDLMEAL 654
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 35.8 bits (81), Expect = 0.066
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
L KV I + + + L+P + G I +G+ G E +II EG AV+
Sbjct: 474 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 533
Query: 310 EEFVEVGRLGPSDYFGEIALL 330
+ V L YFGEI++L
Sbjct: 534 QFVV----LSDGSYFGEISIL 550
Score = 30.0 bits (66), Expect = 3.6
Identities = 20/83 (24%), Positives = 39/83 (46%), Gaps = 8/83 (9%)
Query: 161 GETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGTPRA 212
G+ + ++GD G Y+I +G+ V ++ V +G FGE++++ G R
Sbjct: 503 GDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRT 562
Query: 213 ATVKAKTNVKLWGIDRDSYRRIL 235
A +K+ L+ + +D L
Sbjct: 563 ANIKSIGYSDLFCLSKDDLMEAL 585
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,121,945
Number of Sequences: 37866
Number of extensions: 621265
Number of successful extensions: 2295
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2186
Number of HSP's gapped (non-prelim): 84
length of query: 381
length of database: 18,247,518
effective HSP length: 104
effective length of query: 277
effective length of database: 14,309,454
effective search space: 3963718758
effective search space used: 3963718758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.