Search of human proteins with 4505861

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505861 plasminogen activator, tissue isoform 1
preproprotein [Homo sapiens]
         (562 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505861 plasminogen activator, tissue isoform 1 preproprotein...  1212   0.0  
gi|14702169 plasminogen activator, tissue isoform 3 preproprotei...  1088   0.0  
gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sa...   300   2e-81
gi|4505863 plasminogen activator, urokinase isoform 1 preproprot...   300   2e-81
gi|4504383 HGF activator preproprotein [Homo sapiens]                 293   2e-79
gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapi...   278   1e-74
gi|145275213 coagulation factor XII precursor [Homo sapiens]          274   2e-73
gi|4505881 plasminogen [Homo sapiens]                                 248   1e-65
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]               236   4e-62
gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo s...   180   4e-45
gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Ho...   180   4e-45
gi|205277383 macrophage stimulating 1 (hepatocyte growth factor-...   174   2e-43
gi|4506143 neurotrypsin precursor [Homo sapiens]                      172   6e-43
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           164   2e-40
gi|11415040 matriptase [Homo sapiens]                                 160   2e-39
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         154   3e-37
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          152   8e-37
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          151   1e-36
gi|110815798 ovochymase 1 [Homo sapiens]                              148   1e-35
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   147   2e-35
gi|4503627 coagulation factor XI precursor [Homo sapiens]             147   3e-35
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           147   3e-35
gi|148806900 epidermis-specific serine protease-like protein [Ho...   144   2e-34
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   144   3e-34
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   144   3e-34
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        142   6e-34
gi|11496281 kallikrein 13 precursor [Homo sapiens]                    141   2e-33
gi|117956391 protease, serine, 33 [Homo sapiens]                      141   2e-33
gi|110578663 hypothetical protein LOC203074 [Homo sapiens]            141   2e-33
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   139   5e-33

>gi|4505861 plasminogen activator, tissue isoform 1 preproprotein
           [Homo sapiens]
          Length = 562

 Score = 1212 bits (3137), Expect = 0.0
 Identities = 562/562 (100%), Positives = 562/562 (100%)

Query: 1   MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV 60
           MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
Sbjct: 1   MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV 60

Query: 61  LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 120
           LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
Sbjct: 61  LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 120

Query: 121 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR 180
           IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
Sbjct: 121 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR 180

Query: 181 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN 240
           NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
Sbjct: 181 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN 240

Query: 241 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG 300
           SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
Sbjct: 241 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG 300

Query: 301 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ 360
           LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
Sbjct: 301 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ 360

Query: 361 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA 420
           ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
Sbjct: 361 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA 420

Query: 421 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH 480
           QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
Sbjct: 421 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH 480

Query: 481 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK 540
           LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
Sbjct: 481 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK 540

Query: 541 DVPGVYTKVTNYLDWIRDNMRP 562
           DVPGVYTKVTNYLDWIRDNMRP
Sbjct: 541 DVPGVYTKVTNYLDWIRDNMRP 562


>gi|14702169 plasminogen activator, tissue isoform 3 preproprotein
           [Homo sapiens]
          Length = 516

 Score = 1088 bits (2814), Expect = 0.0
 Identities = 515/562 (91%), Positives = 515/562 (91%), Gaps = 46/562 (8%)

Query: 1   MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV 60
           MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQ                      
Sbjct: 1   MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQ---------------------- 38

Query: 61  LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 120
                                    CSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
Sbjct: 39  ------------------------GCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 74

Query: 121 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR 180
           IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
Sbjct: 75  IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR 134

Query: 181 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN 240
           NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
Sbjct: 135 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN 194

Query: 241 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG 300
           SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
Sbjct: 195 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG 254

Query: 301 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ 360
           LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
Sbjct: 255 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ 314

Query: 361 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA 420
           ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
Sbjct: 315 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA 374

Query: 421 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH 480
           QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
Sbjct: 375 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH 434

Query: 481 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK 540
           LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
Sbjct: 435 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK 494

Query: 541 DVPGVYTKVTNYLDWIRDNMRP 562
           DVPGVYTKVTNYLDWIRDNMRP
Sbjct: 495 DVPGVYTKVTNYLDWIRDNMRP 516


>gi|222537759 plasminogen activator, urokinase isoform 2 [Homo
           sapiens]
          Length = 414

 Score =  300 bits (769), Expect = 2e-81
 Identities = 163/389 (41%), Positives = 214/389 (55%), Gaps = 30/389 (7%)

Query: 189 WCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKV 248
           WC   K  K+  + C      + +  CY GNG  YRG  S    G  CLPWNS  ++ + 
Sbjct: 33  WCNCPK--KFGGQHCEI----DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQT 86

Query: 249 YTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCS----------- 297
           Y A    A  LGLGKHNYCRNPD   +PWC+V    +   + C V  C+           
Sbjct: 87  YHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEE 146

Query: 298 ---TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILS 354
               CG ++  +P+F+I GG F  I + PW AAI+ +H R     ++CGG LIS CW++S
Sbjct: 147 LKFQCG-QKTLRPRFKIIGGEFTTIENQPWFAAIYRRH-RGGSVTYVCGGSLISPCWVIS 204

Query: 355 AAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDT--YDNDIALLQL 412
           A HCF +        V LGR+      + E KFEVE  I+HK++  DT  + NDIALL++
Sbjct: 205 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 264

Query: 413 KSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYP 472
           +S   RCAQ S  ++T+CLP         T CE++G+GK  +    Y E+LK   V+L  
Sbjct: 265 RSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLIS 324

Query: 473 SSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIIS 532
              C   H     VT  MLCA D     PQ    D+CQGDSGGPLVC   GRMTL GI+S
Sbjct: 325 HRECQQPHYYGSEVTTKMLCAAD-----PQWKT-DSCQGDSGGPLVCSLQGRMTLTGIVS 378

Query: 533 WGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
           WG GC  KD PGVYT+V+++L WIR + +
Sbjct: 379 WGRGCALKDKPGVYTRVSHFLPWIRSHTK 407



 Score =  127 bits (319), Expect = 3e-29
 Identities = 59/122 (48%), Positives = 71/122 (58%), Gaps = 1/122 (0%)

Query: 91  CFNGGTCQQALYFSDFV-CQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECT 149
           C NGGTC    YFS+   C CP+ F G+ CEID   TCYE  G  YRG  ST   G  C 
Sbjct: 16  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCL 75

Query: 150 NWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACS 209
            WNS+ + Q+ Y   R DA++LGLG HNYCRNPD   +PWCYV    K   + C    C+
Sbjct: 76  PWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCA 135

Query: 210 EG 211
           +G
Sbjct: 136 DG 137


>gi|4505863 plasminogen activator, urokinase isoform 1 preproprotein
           [Homo sapiens]
          Length = 431

 Score =  300 bits (769), Expect = 2e-81
 Identities = 163/389 (41%), Positives = 214/389 (55%), Gaps = 30/389 (7%)

Query: 189 WCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKV 248
           WC   K  K+  + C      + +  CY GNG  YRG  S    G  CLPWNS  ++ + 
Sbjct: 50  WCNCPK--KFGGQHCEI----DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQT 103

Query: 249 YTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCS----------- 297
           Y A    A  LGLGKHNYCRNPD   +PWC+V    +   + C V  C+           
Sbjct: 104 YHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEE 163

Query: 298 ---TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILS 354
               CG ++  +P+F+I GG F  I + PW AAI+ +H R     ++CGG LIS CW++S
Sbjct: 164 LKFQCG-QKTLRPRFKIIGGEFTTIENQPWFAAIYRRH-RGGSVTYVCGGSLISPCWVIS 221

Query: 355 AAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDT--YDNDIALLQL 412
           A HCF +        V LGR+      + E KFEVE  I+HK++  DT  + NDIALL++
Sbjct: 222 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 281

Query: 413 KSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYP 472
           +S   RCAQ S  ++T+CLP         T CE++G+GK  +    Y E+LK   V+L  
Sbjct: 282 RSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLIS 341

Query: 473 SSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIIS 532
              C   H     VT  MLCA D     PQ    D+CQGDSGGPLVC   GRMTL GI+S
Sbjct: 342 HRECQQPHYYGSEVTTKMLCAAD-----PQWKT-DSCQGDSGGPLVCSLQGRMTLTGIVS 395

Query: 533 WGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
           WG GC  KD PGVYT+V+++L WIR + +
Sbjct: 396 WGRGCALKDKPGVYTRVSHFLPWIRSHTK 424



 Score =  130 bits (327), Expect = 3e-30
 Identities = 64/141 (45%), Positives = 78/141 (55%), Gaps = 5/141 (3%)

Query: 72  NSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFV-CQCPEGFAGKCCEIDTRATCYED 130
           + G  + H VP    S   C NGGTC    YFS+   C CP+ F G+ CEID   TCYE 
Sbjct: 18  SKGSNELHQVP----SNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEG 73

Query: 131 QGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWC 190
            G  YRG  ST   G  C  WNS+ + Q+ Y   R DA++LGLG HNYCRNPD   +PWC
Sbjct: 74  NGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWC 133

Query: 191 YVFKAGKYSSEFCSTPACSEG 211
           YV    K   + C    C++G
Sbjct: 134 YVQVGLKPLVQECMVHDCADG 154


>gi|4504383 HGF activator preproprotein [Homo sapiens]
          Length = 655

 Score =  293 bits (751), Expect = 2e-79
 Identities = 178/519 (34%), Positives = 257/519 (49%), Gaps = 77/519 (14%)

Query: 86  CSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYR---GTWSTA 142
           C+   C NGG+C        + C CP  F GK C  +    C+++    Y      W+  
Sbjct: 164 CASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEK---CFDETRYEYLEGGDRWARV 220

Query: 143 ESG--AECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSS 200
             G   +C  +      +    G R          H  C +    +   C++  A    +
Sbjct: 221 RQGHVEQCECFGGRTWCE----GTR----------HTACLSSPCLNGGTCHLIVAT--GT 264

Query: 201 EFCSTPA------CS-EGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQN 253
             C+ P       C+ E +  C+ GNG+ YRG  S + SG SCL WNS +L  +++    
Sbjct: 265 TVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSV 324

Query: 254 PSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCST--------------- 298
            +A  LGLG H YCRNPD D +PWC+V+K+  L+WEYC + +C +               
Sbjct: 325 GAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRVQLSPDLLATLP 384

Query: 299 ---------CGLRQYSQPQF---RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGIL 346
                    CG R++ +  F   RI GG  +   SHPW AAI+       G+ F C G L
Sbjct: 385 EPASPGRQACG-RRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYI------GDSF-CAGSL 436

Query: 347 ISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFD-DDTYDN 405
           + +CW++SAAHCF    P   ++V+LG+ +     +  Q F +EKYI +  +   +  D+
Sbjct: 437 VHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDH 496

Query: 406 DIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKE 465
           D+ L++LK    RCA  S  V+ +CLP      P   +C+++G+G  +     YS  L+E
Sbjct: 497 DLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLRE 556

Query: 466 AHVRLYPSSRCTSQHLLNRTVTDNMLCAG--DTRSGGPQANLHDACQGDSGGPLVCLNDG 523
           A V L    +C+S  +    ++ NMLCAG  D +S        DACQGDSGGPL C  +G
Sbjct: 557 ALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKS--------DACQGDSGGPLACEKNG 608

Query: 524 RMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP 562
              L GIISWG GCG+   PGVYT+V NY+DWI D +RP
Sbjct: 609 VAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRP 647



 Score =  139 bits (351), Expect = 5e-33
 Identities = 69/168 (41%), Positives = 81/168 (48%), Gaps = 2/168 (1%)

Query: 41  CRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQA 100
           C DE      +    W R  +R   VE C C  GR  C      +C    C NGGTC   
Sbjct: 202 CFDETRYEYLEGGDRWAR--VRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLI 259

Query: 101 LYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKP 160
           +     VC CP GFAG+ C I+    C+   G  YRG  ST+ SG  C  WNS  L Q+ 
Sbjct: 260 VATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQEL 319

Query: 161 YSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPAC 208
           +      A  LGLG H YCRNPD D +PWCYV K    S E+C   AC
Sbjct: 320 HVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEAC 367


>gi|4758502 hyaluronan binding protein 2 preproprotein [Homo
           sapiens]
          Length = 560

 Score =  278 bits (710), Expect = 1e-74
 Identities = 178/513 (34%), Positives = 257/513 (50%), Gaps = 71/513 (13%)

Query: 86  CSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESG 145
           C    C +GG C   ++ S F C C   F+G  C+   + TC ++     RG     +S 
Sbjct: 77  CQPNPCEHGGDC--LVHGSTFTCSCLAPFSGNKCQ-KVQNTCKDNP--CGRGQCLITQSP 131

Query: 146 AECTNWNSSALAQKPYSGR---------RPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAG 196
                     + + PY+G          RP+  + G      C    R SK  C      
Sbjct: 132 PYYR-----CVCKHPYTGPSCSQVVPVCRPNPCQNGAT----CSRHKRRSKFTCAC--PD 180

Query: 197 KYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSA 256
           ++  +FC       G+ DCY G+G +YRG  + T +  +CL WNS +L+ + Y      A
Sbjct: 181 QFKGKFCEI-----GSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDA 235

Query: 257 QALGLGKHNYCRNPDGDAKPWCHV-LKNRRLTWEYCDVPSCS------------------ 297
           +  G+G+HN+CRNPD D KPWC + + N ++ WEYCDV +CS                  
Sbjct: 236 ETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKL 295

Query: 298 ----TCGLRQYSQPQF-RIKGGLFADIASHPWQAAIFAK--HRRSPGERFLCGGILISSC 350
               +CG  + ++ +  RI GG  +    HPWQA++ +      S  +   CGG LI  C
Sbjct: 296 PGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPC 355

Query: 351 WILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFD--DDTYDNDIA 408
           W+L+AAHC        HL V+LG          EQ F VEK   +  ++  D+   NDIA
Sbjct: 356 WVLTAAHCTD--IKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIA 413

Query: 409 LLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHV 468
           LL+LK     CA ES  V+TVCLP  D   P  +EC +SG+G  E      S +L +A V
Sbjct: 414 LLKLKPVDGHCALESKYVKTVCLP--DGSFPSGSECHISGWGVTETGKG--SRQLLDAKV 469

Query: 469 RLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLV 528
           +L  ++ C S+ L +  + D+M+CAG+ +  G      D CQGDSGGPL C  DG   + 
Sbjct: 470 KLIANTLCNSRQLYDHMIDDSMICAGNLQKPG-----QDTCQGDSGGPLTCEKDGTYYVY 524

Query: 529 GIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
           GI+SWGL CG++  PGVYT+VT +L+WI+  ++
Sbjct: 525 GIVSWGLECGKR--PGVYTQVTKFLNWIKATIK 555



 Score =  108 bits (271), Expect = 1e-23
 Identities = 59/145 (40%), Positives = 73/145 (50%), Gaps = 7/145 (4%)

Query: 69  CWCN---SGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRA 125
           C C    +G +    VPV  C    C NG TC +    S F C CP+ F GK CEI +  
Sbjct: 136 CVCKHPYTGPSCSQVVPV--CRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGS-D 192

Query: 126 TCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRD 185
            CY   G SYRG  +   +   C  WNS  L Q+ Y+    DA   G+G HN+CRNPD D
Sbjct: 193 DCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDAD 252

Query: 186 SKPWCYV-FKAGKYSSEFCSTPACS 209
            KPWC++     K   E+C   ACS
Sbjct: 253 EKPWCFIKVTNDKVKWEYCDVSACS 277


>gi|145275213 coagulation factor XII precursor [Homo sapiens]
          Length = 615

 Score =  274 bits (700), Expect = 2e-73
 Identities = 171/523 (32%), Positives = 245/523 (46%), Gaps = 49/523 (9%)

Query: 41  CRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQA 100
           C + +    + +++ W R       V  C C    A C  +  ++C    C +GG C + 
Sbjct: 135 CFEPQLLRFFHKNEIWYRT--EQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEV 192

Query: 101 LYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKP 160
                 +C CP G+ G  C++DT+A+CY+ +G+SYRG   T  SGA C  W S A  +  
Sbjct: 193 --EGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNV 250

Query: 161 YSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNG 220
            +     A   GLG H +CRNPD D +PWC+V    + S E+C    C            
Sbjct: 251 TA---EQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQ----------- 296

Query: 221 SAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHV 280
                T +         P   + L+        P             R P     P    
Sbjct: 297 -----TPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTT---------RTPPQSQTPGALP 342

Query: 281 LKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERF 340
            K  +      + P      LR+      R+ GGL A   +HP+ AA++  H        
Sbjct: 343 AKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS------- 395

Query: 341 LCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDD 400
            C G LI+ CW+L+AAHC Q+R  P  LTV+LG+  R    E  Q   V  Y +H+ F  
Sbjct: 396 FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSP 455

Query: 401 DTYDNDIALLQLKSDS-SRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFY 459
            +Y +D+ALL+L+ D+   CA  S  V+ VCLP    +  + T C+++G+G     +  Y
Sbjct: 456 VSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEY 515

Query: 460 SERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVC 519
           +  L+EA V      RC++  +   ++   MLCAG    G       DACQGDSGGPLVC
Sbjct: 516 ASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGG------TDACQGDSGGPLVC 569

Query: 520 LN---DGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDN 559
            +   + R+TL GIISWG GCG ++ PGVYT V  YL WIR++
Sbjct: 570 EDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREH 612



 Score =  100 bits (250), Expect = 3e-21
 Identities = 72/224 (32%), Positives = 89/224 (39%), Gaps = 46/224 (20%)

Query: 91  CFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISY---RGTWSTAESGA- 146
           C  GGTC      S   C CP+   G  C+   +  C+E Q + +      W   E  A 
Sbjct: 104 CQKGGTCVNMP--SGPHCLCPQHLTGNHCQ---KEKCFEPQLLRFFHKNEIWYRTEQAAV 158

Query: 147 ----------ECTNWNSSALAQKP--YSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFK 194
                      C    S A    P  + GR      L +  H  C  P            
Sbjct: 159 ARCQCKGPDAHCQRLASQACRTNPCLHGGRC-----LEVEGHRLCHCPVG---------- 203

Query: 195 AGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNP 254
              Y+  FC      +  + CY G G +YRG    T SGA C PW S      V   Q  
Sbjct: 204 ---YTGAFCDV----DTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQ-- 254

Query: 255 SAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCST 298
            A+  GLG H +CRNPD D +PWC VL   RL+WEYCD+  C T
Sbjct: 255 -ARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQT 297


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  248 bits (632), Expect = 1e-65
 Identities = 168/465 (36%), Positives = 221/465 (47%), Gaps = 63/465 (13%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLG-NHNYCRNPDRD 185
           CY   G SYRGT ST  +G +C +W+S      P+  ++        G   NYCRNPD D
Sbjct: 377 CYHGDGQSYRGTSSTTTTGKKCQSWSSMT----PHRHQKTPENYPNAGLTMNYCRNPDAD 432

Query: 186 SKPWCYVFKAGKYSSEFCSTPACS--------------------EGNSDCYFGNGSAYRG 225
             PWC+         E+C+   CS                        DC FGNG  YRG
Sbjct: 433 KGPWCFTTDPS-VRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRG 491

Query: 226 THSLTESGASCLPWNSMILIG-KVYTAQ-NPSAQALGLGKHNYCRNPDGDAK-PWCHVLK 282
             + T +G  C  W +       ++T + NP A   GL K NYCRNPDGD   PWC+   
Sbjct: 492 KRATTVTGTPCQDWAAQEPHRHSIFTPETNPRA---GLEK-NYCRNPDGDVGGPWCYTTN 547

Query: 283 NRRLTWEYCDVPSCST----CGLRQYSQPQF--RIKGGLFADIASHPWQAAIFAKHRRSP 336
            R+L ++YCDVP C+     CG  Q    +   R+ GG  A   S PWQ ++    R   
Sbjct: 548 PRKL-YDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSL----RTRF 602

Query: 337 GERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHK 396
           G  F CGG LIS  W+L+AAHC ++   P    VILG    V      Q+ EV +  +  
Sbjct: 603 GMHF-CGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFL-- 659

Query: 397 EFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALS 456
               +    DIALL+L S     A  +  V   CLP  +  + D TEC ++G+G  E   
Sbjct: 660 ----EPTRKDIALLKLSSP----AVITDKVIPACLPSPNYVVADRTECFITGWG--ETQG 709

Query: 457 PFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGP 516
            F +  LKEA + +  +  C     LN  V    LCAG    G       D+CQGDSGGP
Sbjct: 710 TFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGT------DSCQGDSGGP 763

Query: 517 LVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
           LVC    +  L G+ SWGLGC + + PGVY +V+ ++ WI   MR
Sbjct: 764 LVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMR 808



 Score =  116 bits (290), Expect = 6e-26
 Identities = 69/195 (35%), Positives = 89/195 (45%), Gaps = 16/195 (8%)

Query: 111 PEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYS-GRRPDAI 169
           PE     C  ++    C    G +Y G  S   SG EC  W+S    Q P++ G  P   
Sbjct: 169 PEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDS----QSPHAHGYIPSKF 224

Query: 170 RLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPAC------SEGNSDCYFGNGSAY 223
                  NYCRNPDR+ +PWC+     K   E C  P C      S     C  G G  Y
Sbjct: 225 PNKNLKKNYCRNPDRELRPWCFTTDPNK-RWELCDIPRCTTPPPSSGPTYQCLKGTGENY 283

Query: 224 RGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKN 283
           RG  ++T SG +C  W++        T +N   + L     NYCRNPDG   PWCH   N
Sbjct: 284 RGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNL---DENYCRNPDGKRAPWCHT-TN 339

Query: 284 RRLTWEYCDVPSCST 298
            ++ WEYC +PSC +
Sbjct: 340 SQVRWEYCKIPSCDS 354



 Score =  113 bits (283), Expect = 4e-25
 Identities = 64/190 (33%), Positives = 88/190 (46%), Gaps = 28/190 (14%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYS-GRRPDAIRLGLGNHNYCRNPDRD 185
           C +  G +YRG  +   SG  C +W+    AQ P++  R P+       + NYCRNPD  
Sbjct: 275 CLKGTGENYRGNVAVTVSGHTCQHWS----AQTPHTHNRTPENFPCKNLDENYCRNPDGK 330

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSEGN------------------SDCYFGNGSAYRGTH 227
             PWC+   + +   E+C  P+C                       DCY G+G +YRGT 
Sbjct: 331 RAPWCHTTNS-QVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTS 389

Query: 228 SLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLT 287
           S T +G  C  W+SM       T +N     L +   NYCRNPD D  PWC    +  + 
Sbjct: 390 STTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTM---NYCRNPDADKGPWCFT-TDPSVR 445

Query: 288 WEYCDVPSCS 297
           WEYC++  CS
Sbjct: 446 WEYCNLKKCS 455



 Score =  107 bits (268), Expect = 2e-23
 Identities = 77/238 (32%), Positives = 105/238 (44%), Gaps = 30/238 (12%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLG-NHNYCRNPDRD 185
           C    G +YRGT S  ++G  C  W+S++    P+  R   A     G   NYCRNPD D
Sbjct: 103 CKTGNGKNYRGTMSKTKNGITCQKWSSTS----PHRPRFSPATHPSEGLEENYCRNPDND 158

Query: 186 SK-PWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMIL 244
            + PWCY     K   ++C    C E   +C   +G  Y G  S T SG  C  W+S   
Sbjct: 159 PQGPWCYTTDPEK-RYDYCDILECEE---ECMHCSGENYDGKISKTMSGLECQAWDSQSP 214

Query: 245 IGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVL-KNRRLTWEYCDVPSCSTCGLRQ 303
               Y       + L   K NYCRNPD + +PWC     N+R  WE CD+P C+T     
Sbjct: 215 HAHGYIPSKFPNKNL---KKNYCRNPDRELRPWCFTTDPNKR--WELCDIPRCTT--PPP 267

Query: 304 YSQPQFR--------IKGGLFADIASHP---WQAAIFAKHRRSPGERFLCGGILISSC 350
            S P ++         +G +   ++ H    W A     H R+P E F C  +  + C
Sbjct: 268 SSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTP-ENFPCKNLDENYC 324



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 31/85 (36%), Positives = 47/85 (55%), Gaps = 5/85 (5%)

Query: 213 SDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDG 272
           S+C  GNG  YRGT S T++G +C  W+S       ++     ++ L   + NYCRNPD 
Sbjct: 101 SECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGL---EENYCRNPDN 157

Query: 273 DAK-PWCHVLKNRRLTWEYCDVPSC 296
           D + PWC+     +  ++YCD+  C
Sbjct: 158 DPQGPWCYTTDPEK-RYDYCDILEC 181



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 36/100 (36%), Positives = 47/100 (47%), Gaps = 10/100 (10%)

Query: 120 EIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKP--YSGRRPDA-IRLGLGNH 176
           E  +   C    G  YRG  +T  +G  C +W     AQ+P  +S   P+   R GL   
Sbjct: 474 ETPSEEDCMFGNGKGYRGKRATTVTGTPCQDW----AAQEPHRHSIFTPETNPRAGL-EK 528

Query: 177 NYCRNPDRD-SKPWCYVFKAGKYSSEFCSTPACSEGNSDC 215
           NYCRNPD D   PWCY     K   ++C  P C+  + DC
Sbjct: 529 NYCRNPDGDVGGPWCYTTNPRKL-YDYCDVPQCAAPSFDC 567


>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
          Length = 2040

 Score =  236 bits (602), Expect = 4e-62
 Identities = 163/475 (34%), Positives = 217/475 (45%), Gaps = 92/475 (19%)

Query: 127  CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRR-PDAIRLGLGNHNYCRNPDRD 185
            CY   G SYRGT+ST  +G  C +W+S      P+  +R P+         NYCRNPD D
Sbjct: 1616 CYHGNGQSYRGTFSTTVTGRTCQSWSSMT----PHRHQRTPENYPNDGLTMNYCRNPDAD 1671

Query: 186  SKPWCYVFKAGKYSSEFCSTPACSE--------------------GNSDCYFGNGSAYRG 225
            + PWC+         E+C+   CS+                       DC FGNG  YRG
Sbjct: 1672 TGPWCFTMDPS-IRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRG 1730

Query: 226  THSLTESGASCLPWNSMILIGKVYTAQNPSAQAL---------GLGKHNYCRNPDGDAK- 275
              + T +G  C  W           AQ P   +          GL K NYCRNPDGD   
Sbjct: 1731 KKATTVTGTPCQEW----------AAQEPHRHSTFIPGTNKWAGLEK-NYCRNPDGDING 1779

Query: 276  PWCHVLKNRRLTWEYCDVPSCST----CGLRQYSQPQF--RIKGGLFADIASHPWQAAI- 328
            PWC+ +  R+L ++YCD+P C++    CG  Q    +    I GG  A   S PWQ ++ 
Sbjct: 1780 PWCYTMNPRKL-FDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLR 1838

Query: 329  --FAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQK 386
              F KH         CGG LIS  W+L+AAHC ++   P    VILG    V      Q+
Sbjct: 1839 TRFGKH--------FCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLESHVQE 1890

Query: 387  FEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECEL 446
             EV +  +      +    DIALL+L    SR A  +  V   CLP  D  +   TEC +
Sbjct: 1891 IEVSRLFL------EPTQADIALLKL----SRPAVITDKVMPACLPSPDYMVTARTECYI 1940

Query: 447  SGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLH 506
            +G+G  E    F +  LKEA + +  +  C              +CA     G       
Sbjct: 1941 TGWG--ETQGTFGTGLLKEAQLLVIENEVCNHY---------KYICAEHLARGT------ 1983

Query: 507  DACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
            D+CQGDSGGPLVC    +  L G+ SWGLGC + + PGVY +V+ ++ WI   MR
Sbjct: 1984 DSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMR 2038



 Score =  113 bits (282), Expect = 5e-25
 Identities = 65/200 (32%), Positives = 87/200 (43%), Gaps = 38/200 (19%)

Query: 127  CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDS 186
            CY   G SYRGT+ST  +G  C  W+S    Q     R P+         NYCRNPD + 
Sbjct: 1054 CYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQH---SRTPENYPNAGLTRNYCRNPDAEI 1110

Query: 187  KPWCYVFKAGKYSSEFCSTPAC------------------------------SEGNSDCY 216
            +PWCY         E+C+   C                              S G  DCY
Sbjct: 1111 RPWCYTMDPS-VRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCY 1169

Query: 217  FGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKP 276
             G+G +YRG+ S T +G +C  W+SM       T +      L     NYCRNPD +  P
Sbjct: 1170 HGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGL---TRNYCRNPDAEISP 1226

Query: 277  WCHVLKNRRLTWEYCDVPSC 296
            WC+ + +  + WEYC++  C
Sbjct: 1227 WCYTM-DPNVRWEYCNLTQC 1245



 Score =  113 bits (282), Expect = 5e-25
 Identities = 71/203 (34%), Positives = 92/203 (45%), Gaps = 42/203 (20%)

Query: 127  CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLG-NHNYCRNPDRD 185
            CY   G SYRGT ST  +G  C +W+S      P+  RR        G   NYCRNPD +
Sbjct: 1388 CYRGDGQSYRGTLSTTITGRTCQSWSSMT----PHWHRRIPLYYPNAGLTRNYCRNPDAE 1443

Query: 186  SKPWCYVFKAGKYSSEFCSTPACSEGNS------------------------------DC 215
             +PWCY         E+C+   C    S                              DC
Sbjct: 1444 IRPWCYTMDPS-VRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDC 1502

Query: 216  YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQN-PSAQALGLGKHNYCRNPDGDA 274
            Y G+G +YRG  S T +G +C  W+SMI      T +N P+A   GL   NYCRNPD   
Sbjct: 1503 YHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNA---GL-TENYCRNPDSGK 1558

Query: 275  KPWCHVLKNRRLTWEYCDVPSCS 297
            +PWC+   +  + WEYC++  CS
Sbjct: 1559 QPWCYT-TDPCVRWEYCNLTQCS 1580



 Score =  111 bits (278), Expect = 2e-24
 Identities = 68/202 (33%), Positives = 94/202 (46%), Gaps = 42/202 (20%)

Query: 127  CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
            CY   G SY+GT+    +G  C  W+S      P+S  R  A     G   NYCRNPD  
Sbjct: 940  CYHGNGQSYQGTYFITVTGRTCQAWSSMT----PHSHSRTPAYYPNAGLIKNYCRNPDPV 995

Query: 186  SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
            + PWCY         E+C+   CS+                              G  DC
Sbjct: 996  AAPWCYTTDPS-VRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETPGVQDC 1054

Query: 216  YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQN-PSAQALGLGKHNYCRNPDGDA 274
            Y+  G +YRGT+S T +G +C  W+SM       T +N P+A   GL + NYCRNPD + 
Sbjct: 1055 YYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNA---GLTR-NYCRNPDAEI 1110

Query: 275  KPWCHVLKNRRLTWEYCDVPSC 296
            +PWC+ + +  + WEYC++  C
Sbjct: 1111 RPWCYTM-DPSVRWEYCNLTQC 1131



 Score =  111 bits (278), Expect = 2e-24
 Identities = 62/192 (32%), Positives = 87/192 (45%), Gaps = 30/192 (15%)

Query: 127  CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDS 186
            CY   G SYRG++ST  +G  C +W+S       +  R  +    G    NYCRNPD + 
Sbjct: 1168 CYHGDGQSYRGSFSTTVTGRTCQSWSSMT---PHWHQRTTEYYPNGGLTRNYCRNPDAEI 1224

Query: 187  KPWCYVFKAGKYSSEFCSTPACSEGNS----------------------DCYFGNGSAYR 224
             PWCY         E+C+   C    S                      DCY G+G +YR
Sbjct: 1225 SPWCYTMDPN-VRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYR 1283

Query: 225  GTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNR 284
            G+ S T +G +C  W+SM       T +      L     NYCRNPD + +PWC+ + + 
Sbjct: 1284 GSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGL---TRNYCRNPDAEIRPWCYTM-DP 1339

Query: 285  RLTWEYCDVPSC 296
             + WEYC++  C
Sbjct: 1340 SVRWEYCNLTQC 1351



 Score =  110 bits (276), Expect = 3e-24
 Identities = 69/203 (33%), Positives = 94/203 (46%), Gaps = 42/203 (20%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
           CY   G SYRGT+ST  +G  C  W+S      P+S  R        G   NYCRNPD  
Sbjct: 142 CYHGNGQSYRGTYSTTVTGRTCQAWSSMT----PHSHSRTPEYYPNAGLIMNYCRNPDAV 197

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
           + P+CY    G    E+C+   CS+                              G  +C
Sbjct: 198 AAPYCYTRDPG-VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC 256

Query: 216 YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQ-NPSAQALGLGKHNYCRNPDGDA 274
           Y GNG +YRGT+S T +G +C  W+SM       T +  P+A  +     NYCRNPD  A
Sbjct: 257 YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLI----MNYCRNPDAVA 312

Query: 275 KPWCHVLKNRRLTWEYCDVPSCS 297
            P+C+  ++  + WEYC++  CS
Sbjct: 313 APYCYT-RDPGVRWEYCNLTQCS 334



 Score =  110 bits (276), Expect = 3e-24
 Identities = 69/203 (33%), Positives = 94/203 (46%), Gaps = 42/203 (20%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
           CY   G SYRGT+ST  +G  C  W+S      P+S  R        G   NYCRNPD  
Sbjct: 256 CYHGNGQSYRGTYSTTVTGRTCQAWSSMT----PHSHSRTPEYYPNAGLIMNYCRNPDAV 311

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
           + P+CY    G    E+C+   CS+                              G  +C
Sbjct: 312 AAPYCYTRDPG-VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC 370

Query: 216 YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQ-NPSAQALGLGKHNYCRNPDGDA 274
           Y GNG +YRGT+S T +G +C  W+SM       T +  P+A  +     NYCRNPD  A
Sbjct: 371 YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLI----MNYCRNPDAVA 426

Query: 275 KPWCHVLKNRRLTWEYCDVPSCS 297
            P+C+  ++  + WEYC++  CS
Sbjct: 427 APYCYT-RDPGVRWEYCNLTQCS 448



 Score =  110 bits (276), Expect = 3e-24
 Identities = 69/203 (33%), Positives = 94/203 (46%), Gaps = 42/203 (20%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
           CY   G SYRGT+ST  +G  C  W+S      P+S  R        G   NYCRNPD  
Sbjct: 370 CYHGNGQSYRGTYSTTVTGRTCQAWSSMT----PHSHSRTPEYYPNAGLIMNYCRNPDAV 425

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
           + P+CY    G    E+C+   CS+                              G  +C
Sbjct: 426 AAPYCYTRDPG-VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC 484

Query: 216 YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQ-NPSAQALGLGKHNYCRNPDGDA 274
           Y GNG +YRGT+S T +G +C  W+SM       T +  P+A  +     NYCRNPD  A
Sbjct: 485 YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLI----MNYCRNPDAVA 540

Query: 275 KPWCHVLKNRRLTWEYCDVPSCS 297
            P+C+  ++  + WEYC++  CS
Sbjct: 541 APYCYT-RDPGVRWEYCNLTQCS 562



 Score =  110 bits (276), Expect = 3e-24
 Identities = 69/203 (33%), Positives = 94/203 (46%), Gaps = 42/203 (20%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
           CY   G SYRGT+ST  +G  C  W+S      P+S  R        G   NYCRNPD  
Sbjct: 484 CYHGNGQSYRGTYSTTVTGRTCQAWSSMT----PHSHSRTPEYYPNAGLIMNYCRNPDAV 539

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
           + P+CY    G    E+C+   CS+                              G  +C
Sbjct: 540 AAPYCYTRDPG-VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC 598

Query: 216 YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQ-NPSAQALGLGKHNYCRNPDGDA 274
           Y GNG +YRGT+S T +G +C  W+SM       T +  P+A  +     NYCRNPD  A
Sbjct: 599 YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLI----MNYCRNPDAVA 654

Query: 275 KPWCHVLKNRRLTWEYCDVPSCS 297
            P+C+  ++  + WEYC++  CS
Sbjct: 655 APYCYT-RDPGVRWEYCNLTQCS 676



 Score =  110 bits (276), Expect = 3e-24
 Identities = 69/203 (33%), Positives = 94/203 (46%), Gaps = 42/203 (20%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
           CY   G SYRGT+ST  +G  C  W+S      P+S  R        G   NYCRNPD  
Sbjct: 598 CYHGNGQSYRGTYSTTVTGRTCQAWSSMT----PHSHSRTPEYYPNAGLIMNYCRNPDAV 653

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
           + P+CY    G    E+C+   CS+                              G  +C
Sbjct: 654 AAPYCYTRDPG-VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC 712

Query: 216 YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQ-NPSAQALGLGKHNYCRNPDGDA 274
           Y GNG +YRGT+S T +G +C  W+SM       T +  P+A  +     NYCRNPD  A
Sbjct: 713 YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLI----MNYCRNPDAVA 768

Query: 275 KPWCHVLKNRRLTWEYCDVPSCS 297
            P+C+  ++  + WEYC++  CS
Sbjct: 769 APYCYT-RDPGVRWEYCNLTQCS 790



 Score =  110 bits (275), Expect = 3e-24
 Identities = 69/203 (33%), Positives = 94/203 (46%), Gaps = 42/203 (20%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
           CY   G SYRGT+ST  +G  C  W+S      P+S  R        G   NYCRNPD  
Sbjct: 712 CYHGNGQSYRGTYSTTVTGRTCQAWSSMT----PHSHSRTPEYYPNAGLIMNYCRNPDAV 767

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
           + P+CY    G    E+C+   CS+                              G  +C
Sbjct: 768 AAPYCYTRDPG-VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC 826

Query: 216 YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQ-NPSAQALGLGKHNYCRNPDGDA 274
           Y GNG +YRGT+S T +G +C  W+SM       T +  P+A  +     NYCRNPD  A
Sbjct: 827 YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLI----MNYCRNPDPVA 882

Query: 275 KPWCHVLKNRRLTWEYCDVPSCS 297
            P+C+  ++  + WEYC++  CS
Sbjct: 883 APYCYT-RDPSVRWEYCNLTQCS 904



 Score =  110 bits (274), Expect = 4e-24
 Identities = 71/203 (34%), Positives = 95/203 (46%), Gaps = 42/203 (20%)

Query: 127  CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
            CY   G SYRGT+ST  +G  C  W+S      P+S  R        G   NYCRNPD  
Sbjct: 826  CYHGNGQSYRGTYSTTVTGRTCQAWSSMT----PHSHSRTPEYYPNAGLIMNYCRNPDPV 881

Query: 186  SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
            + P+CY  +      E+C+   CS+                              G  +C
Sbjct: 882  AAPYCYT-RDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQEC 940

Query: 216  YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYT-AQNPSAQALGLGKHNYCRNPDGDA 274
            Y GNG +Y+GT+ +T +G +C  W+SM       T A  P+A   GL K NYCRNPD  A
Sbjct: 941  YHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNA---GLIK-NYCRNPDPVA 996

Query: 275  KPWCHVLKNRRLTWEYCDVPSCS 297
             PWC+   +  + WEYC++  CS
Sbjct: 997  APWCYT-TDPSVRWEYCNLTRCS 1018



 Score =  109 bits (273), Expect = 6e-24
 Identities = 66/201 (32%), Positives = 93/201 (46%), Gaps = 40/201 (19%)

Query: 127  CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDS 186
            CY   G SYRG++ST  +G  C +W+S       +  R  +    G    NYCRNPD + 
Sbjct: 1274 CYHGDGQSYRGSFSTTVTGRTCQSWSSMT---PHWHQRTTEYYPNGGLTRNYCRNPDAEI 1330

Query: 187  KPWCYVFKAGKYSSEFCSTPAC------------------------------SEGNSDCY 216
            +PWCY         E+C+   C                              S G  DCY
Sbjct: 1331 RPWCYTMDPS-VRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCY 1389

Query: 217  FGNGSAYRGTHSLTESGASCLPWNSMI-LIGKVYTAQNPSAQALGLGKHNYCRNPDGDAK 275
             G+G +YRGT S T +G +C  W+SM     +      P+A   GL + NYCRNPD + +
Sbjct: 1390 RGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNA---GLTR-NYCRNPDAEIR 1445

Query: 276  PWCHVLKNRRLTWEYCDVPSC 296
            PWC+ + +  + WEYC++  C
Sbjct: 1446 PWCYTM-DPSVRWEYCNLTRC 1465



 Score =  108 bits (271), Expect = 1e-23
 Identities = 68/203 (33%), Positives = 93/203 (45%), Gaps = 42/203 (20%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGN-HNYCRNPDRD 185
           CY   G SYRGT+ST  +G  C  W+S      P+   R        G   NYCRNPD  
Sbjct: 28  CYHGDGQSYRGTYSTTVTGRTCQAWSSMT----PHQHNRTTENYPNAGLIMNYCRNPDAV 83

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSE------------------------------GNSDC 215
           + P+CY    G    E+C+   CS+                              G  +C
Sbjct: 84  AAPYCYTRDPG-VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQEC 142

Query: 216 YFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQ-NPSAQALGLGKHNYCRNPDGDA 274
           Y GNG +YRGT+S T +G +C  W+SM       T +  P+A  +     NYCRNPD  A
Sbjct: 143 YHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLI----MNYCRNPDAVA 198

Query: 275 KPWCHVLKNRRLTWEYCDVPSCS 297
            P+C+  ++  + WEYC++  CS
Sbjct: 199 APYCYT-RDPGVRWEYCNLTQCS 220



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 38/95 (40%), Positives = 55/95 (57%), Gaps = 6/95 (6%)

Query: 204 STPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQN-PSAQALGLG 262
           + P  S    DCY G+G +YRGT+S T +G +C  W+SM       T +N P+A  +   
Sbjct: 17  AAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLI--- 73

Query: 263 KHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCS 297
             NYCRNPD  A P+C+  ++  + WEYC++  CS
Sbjct: 74  -MNYCRNPDAVAAPYCYT-RDPGVRWEYCNLTQCS 106


>gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo
           sapiens]
          Length = 723

 Score =  180 bits (456), Expect = 4e-45
 Identities = 132/447 (29%), Positives = 198/447 (44%), Gaps = 52/447 (11%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYS-GRRPDAIRLGLGNHNYCRNPDRD 185
           C + QG  YRGT +T  +G  C  W+S    Q P+     P+  +      NYCRNPD  
Sbjct: 300 CIQGQGEGYRGTVNTIWNGIPCQRWDS----QYPHEHDMTPENFKCKDLRENYCRNPDGS 355

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSEGNS-DCYFGNGSAYRGTHSLTESGASCLPWNSMIL 244
             PWC+              P C   +  DCY GNG  Y G  S T SG +C  W+  + 
Sbjct: 356 ESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNME 415

Query: 245 IGKVYTAQNPSAQALGLGKHNYCRNPDGDAK-PWCHVLKNRRLTWEYCDVPSC---STCG 300
               +    P A  L     NYCRNPD DA  PWC+   N  + W+YC +  C   +T  
Sbjct: 416 DLHRHIFWEPDASKLN---ENYCRNPDDDAHGPWCYT-GNPLIPWDYCPISRCEGDTTPT 471

Query: 301 LRQYSQP--------QFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWI 352
           +     P        Q R+  G+     +  W  ++  +++       +CGG LI   W+
Sbjct: 472 IVNLDHPVISCAKTKQLRVVNGI-PTRTNIGWMVSLRYRNKH------ICGGSLIKESWV 524

Query: 353 LSAAHCFQERFPPHHLTVILGRTYRVVPGEEE--QKFEVEKYIVHKEFDDDTYDNDIALL 410
           L+A  CF  R    +    LG       G+E+  Q   V + +   E       +D+ L+
Sbjct: 525 LTARQCFPSRDLKDY-EAWLGIHDVHGRGDEKCKQVLNVSQLVYGPE------GSDLVLM 577

Query: 411 QLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRL 470
           +L    +R A     V T+ LP     +P+ T C + G+G    ++  Y   L+ AH+ +
Sbjct: 578 KL----ARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLIN--YDGLLRVAHLYI 631

Query: 471 YPSSRCTSQHLLNRTVTDNMLCAGDTRSG-GPQANLHDACQGDSGGPLVCLNDGRMTLVG 529
             + +C+  H    T+ ++ +CAG  + G GP       C+GD GGPLVC       ++G
Sbjct: 632 MGNEKCSQHHRGKVTLNESEICAGAEKIGSGP-------CEGDYGGPLVCEQHKMRMVLG 684

Query: 530 IISWGLGCGQKDVPGVYTKVTNYLDWI 556
           +I  G GC   + PG++ +V  Y  WI
Sbjct: 685 VIVPGRGCAIPNRPGIFVRVAYYAKWI 711



 Score =  102 bits (255), Expect = 7e-22
 Identities = 58/172 (33%), Positives = 80/172 (46%), Gaps = 16/172 (9%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNP-DRD 185
           C   +G SY+GT S  +SG +C  W+S    +  Y G+            NYCRNP   +
Sbjct: 128 CIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSYRGKDLQ--------ENYCRNPRGEE 179

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILI 245
             PWC+     +   E C  P CSE   +C   NG +YRG    TESG  C  W+     
Sbjct: 180 GGPWCFTSNP-EVRYEVCDIPQCSE--VECMTCNGESYRGLMDHTESGKICQRWDHQTPH 236

Query: 246 GKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCS 297
              +  +    +       NYCRNPDG  +PWC+ L +    WEYC + +C+
Sbjct: 237 RHKFLPERYPDKGFD---DNYCRNPDGQPRPWCYTL-DPHTRWEYCAIKTCA 284



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 69/227 (30%), Positives = 95/227 (41%), Gaps = 36/227 (15%)

Query: 86  CSEPRCFNGG----TCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWST 141
           C  PR   GG    T    + +   VC  P+     C E++    C    G SYRG    
Sbjct: 172 CRNPRGEEGGPWCFTSNPEVRYE--VCDIPQ-----CSEVE----CMTCNGESYRGLMDH 220

Query: 142 AESGAECTNWNSSALAQKPYSGRR-PDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSS 200
            ESG  C  W+     +  +   R PD    G  + NYCRNPD   +PWCY         
Sbjct: 221 TESGKICQRWDHQTPHRHKFLPERYPDK---GFDD-NYCRNPDGQPRPWCYTLDPHT-RW 275

Query: 201 EFCSTPACSEGN----------SDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYT 250
           E+C+   C++            ++C  G G  YRGT +   +G  C  W+S        T
Sbjct: 276 EYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMT 335

Query: 251 AQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYC-DVPSC 296
            +N   + L   + NYCRNPDG   PWC    +  +   YC  +P+C
Sbjct: 336 PENFKCKDL---RENYCRNPDGSESPWCFT-TDPNIRVGYCSQIPNC 378



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 37/97 (38%), Positives = 50/97 (51%), Gaps = 15/97 (15%)

Query: 214 DCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDG- 272
           +C  G G +Y+GT S+T+SG  C PW+SMI     Y  ++         + NYCRNP G 
Sbjct: 127 NCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSYRGKDL--------QENYCRNPRGE 178

Query: 273 DAKPWCHVLKNRRLTWEYCDVPSCS-----TCGLRQY 304
           +  PWC    N  + +E CD+P CS     TC    Y
Sbjct: 179 EGGPWCFT-SNPEVRYEVCDIPQCSEVECMTCNGESY 214



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 28/74 (37%), Positives = 37/74 (50%), Gaps = 4/74 (5%)

Query: 119 CEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNY 178
           C++     CY   G +Y G  S   SG  C+ W+ +      +    PDA +L   N NY
Sbjct: 378 CDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKL---NENY 434

Query: 179 CRNPDRDSK-PWCY 191
           CRNPD D+  PWCY
Sbjct: 435 CRNPDDDAHGPWCY 448


>gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Homo
           sapiens]
          Length = 728

 Score =  180 bits (456), Expect = 4e-45
 Identities = 132/447 (29%), Positives = 198/447 (44%), Gaps = 52/447 (11%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYS-GRRPDAIRLGLGNHNYCRNPDRD 185
           C + QG  YRGT +T  +G  C  W+S    Q P+     P+  +      NYCRNPD  
Sbjct: 305 CIQGQGEGYRGTVNTIWNGIPCQRWDS----QYPHEHDMTPENFKCKDLRENYCRNPDGS 360

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSEGNS-DCYFGNGSAYRGTHSLTESGASCLPWNSMIL 244
             PWC+              P C   +  DCY GNG  Y G  S T SG +C  W+  + 
Sbjct: 361 ESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNME 420

Query: 245 IGKVYTAQNPSAQALGLGKHNYCRNPDGDAK-PWCHVLKNRRLTWEYCDVPSC---STCG 300
               +    P A  L     NYCRNPD DA  PWC+   N  + W+YC +  C   +T  
Sbjct: 421 DLHRHIFWEPDASKLN---ENYCRNPDDDAHGPWCYT-GNPLIPWDYCPISRCEGDTTPT 476

Query: 301 LRQYSQP--------QFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWI 352
           +     P        Q R+  G+     +  W  ++  +++       +CGG LI   W+
Sbjct: 477 IVNLDHPVISCAKTKQLRVVNGI-PTRTNIGWMVSLRYRNKH------ICGGSLIKESWV 529

Query: 353 LSAAHCFQERFPPHHLTVILGRTYRVVPGEEE--QKFEVEKYIVHKEFDDDTYDNDIALL 410
           L+A  CF  R    +    LG       G+E+  Q   V + +   E       +D+ L+
Sbjct: 530 LTARQCFPSRDLKDY-EAWLGIHDVHGRGDEKCKQVLNVSQLVYGPE------GSDLVLM 582

Query: 411 QLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRL 470
           +L    +R A     V T+ LP     +P+ T C + G+G    ++  Y   L+ AH+ +
Sbjct: 583 KL----ARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLIN--YDGLLRVAHLYI 636

Query: 471 YPSSRCTSQHLLNRTVTDNMLCAGDTRSG-GPQANLHDACQGDSGGPLVCLNDGRMTLVG 529
             + +C+  H    T+ ++ +CAG  + G GP       C+GD GGPLVC       ++G
Sbjct: 637 MGNEKCSQHHRGKVTLNESEICAGAEKIGSGP-------CEGDYGGPLVCEQHKMRMVLG 689

Query: 530 IISWGLGCGQKDVPGVYTKVTNYLDWI 556
           +I  G GC   + PG++ +V  Y  WI
Sbjct: 690 VIVPGRGCAIPNRPGIFVRVAYYAKWI 716



 Score =  100 bits (250), Expect = 3e-21
 Identities = 58/172 (33%), Positives = 81/172 (47%), Gaps = 11/172 (6%)

Query: 127 CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNP-DRD 185
           C   +G SY+GT S  +SG +C  W+S    +  +    P + R      NYCRNP   +
Sbjct: 128 CIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFL---PSSYRGKDLQENYCRNPRGEE 184

Query: 186 SKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILI 245
             PWC+     +   E C  P CSE   +C   NG +YRG    TESG  C  W+     
Sbjct: 185 GGPWCFTSNP-EVRYEVCDIPQCSE--VECMTCNGESYRGLMDHTESGKICQRWDHQTPH 241

Query: 246 GKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCS 297
              +  +    +       NYCRNPDG  +PWC+ L +    WEYC + +C+
Sbjct: 242 RHKFLPERYPDKGFD---DNYCRNPDGQPRPWCYTL-DPHTRWEYCAIKTCA 289



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 69/227 (30%), Positives = 95/227 (41%), Gaps = 36/227 (15%)

Query: 86  CSEPRCFNGG----TCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWST 141
           C  PR   GG    T    + +   VC  P+     C E++    C    G SYRG    
Sbjct: 177 CRNPRGEEGGPWCFTSNPEVRYE--VCDIPQ-----CSEVE----CMTCNGESYRGLMDH 225

Query: 142 AESGAECTNWNSSALAQKPYSGRR-PDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSS 200
            ESG  C  W+     +  +   R PD    G  + NYCRNPD   +PWCY         
Sbjct: 226 TESGKICQRWDHQTPHRHKFLPERYPDK---GFDD-NYCRNPDGQPRPWCYTLDPHT-RW 280

Query: 201 EFCSTPACSEGN----------SDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYT 250
           E+C+   C++            ++C  G G  YRGT +   +G  C  W+S        T
Sbjct: 281 EYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMT 340

Query: 251 AQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYC-DVPSC 296
            +N   + L   + NYCRNPDG   PWC    +  +   YC  +P+C
Sbjct: 341 PENFKCKDL---RENYCRNPDGSESPWCFT-TDPNIRVGYCSQIPNC 383



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 37/97 (38%), Positives = 51/97 (52%), Gaps = 10/97 (10%)

Query: 214 DCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDG- 272
           +C  G G +Y+GT S+T+SG  C PW+SMI     +   +   + L   + NYCRNP G 
Sbjct: 127 NCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDL---QENYCRNPRGE 183

Query: 273 DAKPWCHVLKNRRLTWEYCDVPSCS-----TCGLRQY 304
           +  PWC    N  + +E CD+P CS     TC    Y
Sbjct: 184 EGGPWCFT-SNPEVRYEVCDIPQCSEVECMTCNGESY 219



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 28/74 (37%), Positives = 37/74 (50%), Gaps = 4/74 (5%)

Query: 119 CEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNY 178
           C++     CY   G +Y G  S   SG  C+ W+ +      +    PDA +L   N NY
Sbjct: 383 CDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKL---NENY 439

Query: 179 CRNPDRDSK-PWCY 191
           CRNPD D+  PWCY
Sbjct: 440 CRNPDDDAHGPWCY 453


>gi|205277383 macrophage stimulating 1 (hepatocyte growth
           factor-like) [Homo sapiens]
          Length = 725

 Score =  174 bits (441), Expect = 2e-43
 Identities = 135/464 (29%), Positives = 196/464 (42%), Gaps = 58/464 (12%)

Query: 123 TRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGR-RPDAIRLGLGNHNYCRN 181
           T  +C+  +G  YRGT +T  +G  C  W+    AQ P+  R  P+         N+CRN
Sbjct: 293 TTVSCFRGKGEGYRGTANTTTAGVPCQRWD----AQIPHQHRFTPEKYACKDLRENFCRN 348

Query: 182 PDRDSKPWCYVFKAGKYSSEFCSTPACSEG--NSDCYFGNGSAYRGTHSLTESGASCLPW 239
           PD    PWC+  + G  ++       C++     DCY G G  YRGT S T  G  C  W
Sbjct: 349 PDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRW 408

Query: 240 NSMILIGKVYT-AQNPSAQALGLGKHNYCRNPDGDAK-PWCHVLKNRRLTWEYCDVPSCS 297
           ++       +T    P AQ     + N+CRNPDGD+  PWC+ + + R  ++YC +  C+
Sbjct: 409 SAETPHKPQFTFTSEPHAQL----EENFCRNPDGDSHGPWCYTM-DPRTPFDYCALRRCA 463

Query: 298 T-----------------CGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERF 340
                             CG R     Q R K      +  HP  +      R   G+ F
Sbjct: 464 DDQPPSILDPPDQVQFEKCGKRVDRLDQRRSK---LRVVGGHPGNSPWTVSLRNRQGQHF 520

Query: 341 LCGGILISSCWILSAAHCFQE-RFPPHHLTVILGRTYRVVPGEEE--QKFEVEKYIVHKE 397
            CGG L+   WIL+A  CF     P     V LG  ++     E   Q+  V K +    
Sbjct: 521 -CGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPS 579

Query: 398 FDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSP 457
                  + + LL+L+    R    +  V  +CLPP    +P  T+CE++G+G+ +    
Sbjct: 580 ------GSQLVLLKLE----RSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGN 629

Query: 458 FYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPL 517
                L  A + +  +  C  +H   R     M   G     G       AC+GD GGPL
Sbjct: 630 --DTVLNVALLNVISNQECNIKHR-GRVRESEMCTEGLLAPVG-------ACEGDYGGPL 679

Query: 518 VCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
            C       L GII     C +   P V+T+V+ ++DWI   MR
Sbjct: 680 ACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMR 723



 Score =  108 bits (271), Expect = 1e-23
 Identities = 79/250 (31%), Positives = 111/250 (44%), Gaps = 51/250 (20%)

Query: 126 TCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRD 185
           TC  + G+ YRGT +T   G  C  W+       P   +    +R GL   N+CRNPD D
Sbjct: 123 TCIMNNGVGYRGTMATTVGGLPCQAWSHKF----PNDHKYTPTLRNGL-EENFCRNPDGD 177

Query: 186 -SKPWCYVFK-AGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMI 243
              PWCY    A ++ S  C   +C E  + C + NG  YRG    TESG  C  W+   
Sbjct: 178 PGGPWCYTTDPAVRFQS--CGIKSCRE--AACVWCNGEEYRGAVDRTESGRECQRWD--- 230

Query: 244 LIGKVYTAQNPSAQALGLGKH-------NYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSC 296
                   Q+P       GK        NYCRNPDG  +PWC+   + ++  E+CD+P C
Sbjct: 231 -------LQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYT-TDPQIEREFCDLPRC 282

Query: 297 STCGLRQYSQPQ--------FRIKGGLF--------ADIASHPWQAAIFAKHRRSPGERF 340
            +      +QP+        FR KG  +        A +    W A I  +HR +P E++
Sbjct: 283 GS-----EAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTP-EKY 336

Query: 341 LCGGILISSC 350
            C  +  + C
Sbjct: 337 ACKDLRENFC 346



 Score =  104 bits (259), Expect = 2e-22
 Identities = 59/166 (35%), Positives = 78/166 (46%), Gaps = 15/166 (9%)

Query: 125 ATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDR 184
           A C    G  YRG     ESG EC  W+     Q P+   +   +  GL + NYCRNPD 
Sbjct: 203 AACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGK--FLDQGL-DDNYCRNPDG 259

Query: 185 DSKPWCYVFKAGKYSSEFCSTPAC-SEGNS-------DCYFGNGSAYRGTHSLTESGASC 236
             +PWCY     +   EFC  P C SE           C+ G G  YRGT + T +G  C
Sbjct: 260 SERPWCYTTDP-QIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPC 318

Query: 237 LPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLK 282
             W++ I     +T +  + + L   + N+CRNPDG   PWC  L+
Sbjct: 319 QRWDAQIPHQHRFTPEKYACKDL---RENFCRNPDGSEAPWCFTLR 361



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 6/94 (6%)

Query: 119 CEIDTRAT-CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHN 177
           C  D R   CY   G  YRGT S    G +C  W++    +  ++       +L     N
Sbjct: 375 CTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQL---EEN 431

Query: 178 YCRNPDRDSK-PWCYVFKAGKYSSEFCSTPACSE 210
           +CRNPD DS  PWCY     +   ++C+   C++
Sbjct: 432 FCRNPDGDSHGPWCYTMDP-RTPFDYCALRRCAD 464


>gi|4506143 neurotrypsin precursor [Homo sapiens]
          Length = 875

 Score =  172 bits (437), Expect = 6e-43
 Identities = 112/305 (36%), Positives = 161/305 (52%), Gaps = 26/305 (8%)

Query: 261 LGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIA 320
           +G+HN CR+ + DA   C     ++ +         S CGLR   + Q RI GG  +   
Sbjct: 584 IGRHN-CRHSE-DAGVICDYF-GKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRG 640

Query: 321 SHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERF-PPHHLTVILGRTYRVV 379
             PWQ ++  K     G R LCG  L+SSCW+L+AAHCF+          V +G  + +V
Sbjct: 641 GWPWQVSLRLKSSHGDG-RLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLV 699

Query: 380 PGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPP-ADLQL 438
           P E E++  V++ ++H+E+  D  D DIAL++L+    +CA+ SS V   CLP   +   
Sbjct: 700 PEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQ 759

Query: 439 PDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRS 498
              + C ++G+G        YS  L++A + L P   C  ++      T  MLCAG    
Sbjct: 760 KTASNCYITGWGD---TGRAYSRTLQQAAIPLLPKRFCEERY--KGRFTGRMLCAG---- 810

Query: 499 GGPQANLH-----DACQGDSGGPLVCLNDGRMTLV-GIISWGLGCGQKDVPGVYTKVTNY 552
                NLH     D+CQGDSGGPL+C   G   +V G+ SWG GCG KD PGVYTKV+ +
Sbjct: 811 -----NLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAF 865

Query: 553 LDWIR 557
           + WI+
Sbjct: 866 VPWIK 870



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 7/68 (10%)

Query: 228 SLTESGASCLPWNSMILIGKVYTAQNPSAQALGLG--KHNYCRNPDGDAKPWCHVLKNR- 284
           S+T+ GA CL W  +      +  ++P A    L   +HN+CR+PDG  +PWC     R 
Sbjct: 101 SVTDFGAPCLRWAEV----PPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARG 156

Query: 285 RLTWEYCD 292
           ++ W YCD
Sbjct: 157 KVDWGYCD 164



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/97 (31%), Positives = 42/97 (43%), Gaps = 11/97 (11%)

Query: 140 STAESGAECTNWNSSALAQKPYSGRRPDA--IRLGLGNHNYCRNPDRDSKPWCYVFKA-G 196
           S  + GA C  W        P+  R P A   +L    HN+CR+PD   +PWC+   A G
Sbjct: 101 SVTDFGAPCLRWAEVP----PFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARG 156

Query: 197 KYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESG 233
           K    +C    C  G S    G  + + GT  +  SG
Sbjct: 157 KVDWGYCD---CRHG-SVRLRGGKNEFEGTVEVYASG 189


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  164 bits (415), Expect = 2e-40
 Identities = 106/292 (36%), Positives = 150/292 (51%), Gaps = 35/292 (11%)

Query: 269 NPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAI 328
           NP  D +P C    +     E+CD      CGL+    P  RI GG  +     PWQA++
Sbjct: 548 NPQCDGRPDCRDGSDE----EHCD------CGLQG---PSSRIVGGAVSSEGEWPWQASL 594

Query: 329 FAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHL--TVILGRTYRVVPGEEEQK 386
             + R       +CGG LI+  W+++AAHCFQE      +  TV LG+ ++      E  
Sbjct: 595 QVRGRH------ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVS 648

Query: 387 FEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECEL 446
           F+V + ++H   ++D++D D+ALLQL     R    S+ VR VCLP           C +
Sbjct: 649 FKVSRLLLHPYHEEDSHDYDVALLQLDHPVVR----SAAVRPVCLPARSHFFEPGLHCWI 704

Query: 447 SGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLH 506
           +G+G      P  S  L++  V+L P   C+  +     VT  MLCAG  +         
Sbjct: 705 TGWGALREGGPI-SNALQKVDVQLIPQDLCSEVYRYQ--VTPRMLCAGYRKGK------K 755

Query: 507 DACQGDSGGPLVCLN-DGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIR 557
           DACQGDSGGPLVC    GR  L G++SWGLGCG+ +  GVYT++T  + WI+
Sbjct: 756 DACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQ 807


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  160 bits (406), Expect = 2e-39
 Identities = 123/366 (33%), Positives = 182/366 (49%), Gaps = 54/366 (14%)

Query: 203 CSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLG 262
           CS   C   +  C   NG    G  S     ASC   N +      Y   N    + G  
Sbjct: 532 CSNGKCLSKSQQC---NGKDDCGDGS---DEASCPKVNVVTCTKHTYRCLNGLCLSKG-- 583

Query: 263 KHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASH 322
                 NP+ D K  C          +  D   C  CGLR +++ Q R+ GG  AD    
Sbjct: 584 ------NPECDGKEDCS---------DGSDEKDCD-CGLRSFTR-QARVVGGTDADEGEW 626

Query: 323 PWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQE----RFP-PHHLTVILG---R 374
           PWQ ++ A      G+  +CG  LIS  W++SAAHC+ +    R+  P   T  LG   +
Sbjct: 627 PWQVSLHAL-----GQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQ 681

Query: 375 TYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPA 434
           + R  PG +E++  +++ I H  F+D T+D DIALL+L+      A+ SS+VR +CLP A
Sbjct: 682 SQRSAPGVQERR--LKRIISHPFFNDFTFDYDIALLELEKP----AEYSSMVRPICLPDA 735

Query: 435 DLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAG 494
               P      ++G+G H       +  L++  +R+   + C  ++LL + +T  M+C G
Sbjct: 736 SHVFPAGKAIWVTGWG-HTQYGGTGALILQKGEIRVINQTTC--ENLLPQQITPRMMCVG 792

Query: 495 DTRSGGPQANLHDACQGDSGGPLVCLN-DGRMTLVGIISWGLGCGQKDVPGVYTKVTNYL 553
              SGG      D+CQGDSGGPL  +  DGR+   G++SWG GC Q++ PGVYT++  + 
Sbjct: 793 FL-SGGV-----DSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFR 846

Query: 554 DWIRDN 559
           DWI++N
Sbjct: 847 DWIKEN 852


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  154 bits (388), Expect = 3e-37
 Identities = 94/267 (35%), Positives = 131/267 (49%), Gaps = 24/267 (8%)

Query: 296 CSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSA 355
           CS CGLR  +    RI GG  A  +  PWQ ++        G   +CGG LI + W+L+A
Sbjct: 314 CSHCGLRAMTG---RIVGGALASDSKWPWQVSLHF------GTTHICGGTLIDAQWVLTA 364

Query: 356 AHCFQERFPPHHLTVILGRTYRVVPGEEE--QKFEVEKYIVHKEFDDDTYDNDIALLQLK 413
           AHCF   F      +   + Y       +  +   + + I++  + D+  D DIAL++L 
Sbjct: 365 AHCF---FVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL- 420

Query: 414 SDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPS 473
              S+    S+ +   CLP           C ++G+GK        S  L+E  V L   
Sbjct: 421 ---SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDF 477

Query: 474 SRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISW 533
            +C    + +  +T  M+CAGD R G       D+CQGDSGGPLVC  + R  L G+ SW
Sbjct: 478 KKCNDYLVYDSYLTPRMMCAGDLRGG------RDSCQGDSGGPLVCEQNNRWYLAGVTSW 531

Query: 534 GLGCGQKDVPGVYTKVTNYLDWIRDNM 560
           G GCGQ++ PGVYTKVT  L WI   M
Sbjct: 532 GTGCGQRNKPGVYTKVTEVLPWIYSKM 558


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  152 bits (384), Expect = 8e-37
 Identities = 95/272 (34%), Positives = 135/272 (49%), Gaps = 36/272 (13%)

Query: 296 CSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSA 355
           CS CG R  +    RI GG        PWQA++      + G R  CGG +++  W+++A
Sbjct: 206 CSECGARPLAS---RIVGGQSVAPGRWPWQASV------ALGFRHTCGGSVLAPRWVVTA 256

Query: 356 AHCFQERFPPHHLTVILGRTYRVVPG-------EEEQKFEVEKYIVHKEFDDDTYDNDIA 408
           AHC       H   +    ++RV  G          Q   VE+ I H  +    +D D+A
Sbjct: 257 AHCM------HSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVA 310

Query: 409 LLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHV 468
           LL+L++        S  V  VCLP  +   P  + C +SG+G       + S+ L++  V
Sbjct: 311 LLRLQT----ALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVV 366

Query: 469 RLYPSSRCTSQHLLNRTVTDNMLCAG--DTRSGGPQANLHDACQGDSGGPLVCLNDGRMT 526
            L+ +  C S  + +  +T  MLCAG  D R+        DACQGDSGGPLVC +     
Sbjct: 367 PLFSTQLCNSSCVYSGALTPRMLCAGYLDGRA--------DACQGDSGGPLVCPDGDTWR 418

Query: 527 LVGIISWGLGCGQKDVPGVYTKVTNYLDWIRD 558
           LVG++SWG GC + + PGVY KV  +LDWI D
Sbjct: 419 LVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHD 450


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  151 bits (382), Expect = 1e-36
 Identities = 90/249 (36%), Positives = 130/249 (52%), Gaps = 22/249 (8%)

Query: 310 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLT 369
           RI GG  A+  S PWQ ++   +         CGG LI++ WIL+AAHCF+    P    
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHH------CGGSLINNMWILTAAHCFRSNSNPRDWI 239

Query: 370 VILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTV 429
              G    +     + +  V   ++H  +   T++NDIAL++L++  +        + +V
Sbjct: 240 ATSG----ISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKD----IHSV 291

Query: 430 CLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDN 489
           CLP A   +P  +   ++G+G  E       E L++  VR+  +  C + H  N  +   
Sbjct: 292 CLPAATQNIPPGSTAYVTGWGAQEYAGHTVPE-LRQGQVRIISNDVCNAPHSYNGAILSG 350

Query: 490 MLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMT-LVGIISWGLGCGQKDVPGVYTK 548
           MLCAG  + G       DACQGDSGGPLV  +  R+  +VGI+SWG  CG  D PGVYT+
Sbjct: 351 MLCAGVPQGGV------DACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTR 404

Query: 549 VTNYLDWIR 557
           VT YLDWIR
Sbjct: 405 VTAYLDWIR 413


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  148 bits (374), Expect = 1e-35
 Identities = 102/268 (38%), Positives = 142/268 (52%), Gaps = 23/268 (8%)

Query: 299 CGLRQYSQPQF---RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSA 355
           CG+  +S PQ+   RI GG  A     PWQ  +     R  G+ + CGG +I+  WIL+A
Sbjct: 561 CGIPPFS-PQWLSRRIAGGEEACPHCWPWQVGL-----RFLGD-YQCGGAIINPVWILTA 613

Query: 356 AHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSD 415
           AHC Q +  P   T+I G   R +    EQ    +  IVH++F+  +YD+DIAL+QL S 
Sbjct: 614 AHCVQLKNNPLSWTIIAGDHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSP 673

Query: 416 SSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSR 475
                + +SVVR VCLP +   L     C ++G+G   A     S RL++  V +     
Sbjct: 674 ----LEYNSVVRPVCLPHSAEPLFSSEICAVTGWGSISADGGLAS-RLQQIQVHVLEREV 728

Query: 476 CTSQHLLNRT--VTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLND-GRMTLVGIIS 532
           C   +       +T+ M+CAG   SG       D CQGDSGGPLVC ++ G   L GI+S
Sbjct: 729 CEHTYYSAHPGGITEKMICAGFAASGE-----KDFCQGDSGGPLVCRHENGPFVLYGIVS 783

Query: 533 WGLGCGQKDVPGVYTKVTNYLDWIRDNM 560
           WG GC Q   PGV+ +V  +LDWI+  +
Sbjct: 784 WGAGCVQPWKPGVFARVMIFLDWIQSKI 811



 Score =  112 bits (279), Expect = 1e-24
 Identities = 90/271 (33%), Positives = 124/271 (45%), Gaps = 41/271 (15%)

Query: 310 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPH--H 367
           RI     + +  HPWQ ++         E   CGG LI    +++AAHC          +
Sbjct: 46  RISSWRNSTVTGHPWQVSL------KSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKN 99

Query: 368 LTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDN-DIALLQLKSDSSRCAQESSVV 426
           +TV  G        ++EQ   V K I H E++   Y + DIALL LK       +  + V
Sbjct: 100 ITVTSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHK----VKFGNAV 155

Query: 427 RTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCT----SQHL- 481
           + +CLP +D ++     C  SG+GK    S  YS  L+E  + +     C     S +L 
Sbjct: 156 QPICLPDSDDKVEPGILCLSSGWGKISKTSE-YSNVLQEMELPIMDDRACNTVLKSMNLP 214

Query: 482 -LNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRM-TLVGIISWGLGCGQ 539
            L RT    MLCAG    G       DACQGDSGGPLVC   G +  L GI SW  GC  
Sbjct: 215 PLGRT----MLCAGFPDWG------MDACQGDSGGPLVCRRGGGIWILAGITSWVAGCAG 264

Query: 540 KDVP----------GVYTKVTNYLDWIRDNM 560
             VP          G+++KV+  +D+I  N+
Sbjct: 265 GSVPVRNNHVKASLGIFSKVSELMDFITQNL 295


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  147 bits (372), Expect = 2e-35
 Identities = 92/266 (34%), Positives = 138/266 (51%), Gaps = 22/266 (8%)

Query: 296 CSTCGLRQ-YSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILS 354
           C+ CG R+ YS    RI GG  + ++  PWQA++  +         LCGG +I+  WI++
Sbjct: 204 CTACGHRRGYSS---RIVGGNMSLLSQWPWQASLQFQGYH------LCGGSVITPLWIIT 254

Query: 355 AAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKS 414
           AAHC  + + P   T+ +G    +          VEK + H ++      NDIAL++L  
Sbjct: 255 AAHCVYDLYLPKSWTIQVGLVSLL--DNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAG 312

Query: 415 DSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSS 474
             +     + +++ VCLP ++   PD   C  SG+G  E  +   S  L  A V L  + 
Sbjct: 313 PLTF----NEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNK 368

Query: 475 RCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWG 534
            C  + +    ++ +MLCAG    G       D+CQGDSGGPLVC       LVG  S+G
Sbjct: 369 ICNHRDVYGGIISPSMLCAGYLTGGV------DSCQGDSGGPLVCQERRLWKLVGATSFG 422

Query: 535 LGCGQKDVPGVYTKVTNYLDWIRDNM 560
           +GC + + PGVYT+VT++LDWI + M
Sbjct: 423 IGCAEVNKPGVYTRVTSFLDWIHEQM 448


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  147 bits (371), Expect = 3e-35
 Identities = 91/247 (36%), Positives = 133/247 (53%), Gaps = 15/247 (6%)

Query: 310 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLT 369
           RI GG  +     PWQ  +   H  SP +R LCGG +I + WIL+AAHCF     P  L 
Sbjct: 387 RIVGGTASVRGEWPWQVTL---HTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILR 443

Query: 370 VILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTV 429
           V  G   +    E+   F V++ I+H ++       DIALL+L++  +    +    R +
Sbjct: 444 VYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQ----RPI 499

Query: 430 CLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDN 489
           CLP    +   +T+C ++G+G +  L       L++A + L  +  C  ++  ++ +T  
Sbjct: 500 CLPSKGDRNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHK-ITHK 557

Query: 490 MLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKV 549
           M+CAG  R GG      DAC+GDSGGPL C ++    LVGI SWG GC Q++ PGVYT V
Sbjct: 558 MICAG-YREGGK-----DACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNV 611

Query: 550 TNYLDWI 556
             Y+DWI
Sbjct: 612 VEYVDWI 618


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  147 bits (370), Expect = 3e-35
 Identities = 95/259 (36%), Positives = 132/259 (50%), Gaps = 19/259 (7%)

Query: 299 CGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHC 358
           CGL+   +   RI GG+ A     PWQA++     R   E F CG  +I++ W++SAAHC
Sbjct: 191 CGLQPAWRMAGRIVGGMEASPGEFPWQASL-----RENKEHF-CGAAIINARWLVSAAHC 244

Query: 359 FQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSR 418
           F E   P      +G TY         + +V + + H  ++ DT D D+A+L+L S    
Sbjct: 245 FNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSP--- 301

Query: 419 CAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTS 478
                  ++ VCLP A    P   +C +SG+G  +       E L++A V L   + C S
Sbjct: 302 -LPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS 360

Query: 479 QHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN-DGRMTLVGIISWGLGC 537
             L   ++TD M+CAG            D+CQGDSGGPLVC    GR  L GI+SWG+GC
Sbjct: 361 --LYGHSLTDRMVCAGYL------DGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGC 412

Query: 538 GQKDVPGVYTKVTNYLDWI 556
            +   PGVY +VT   DWI
Sbjct: 413 AEARRPGVYARVTRLRDWI 431



 Score =  141 bits (356), Expect = 1e-33
 Identities = 88/273 (32%), Positives = 131/273 (47%), Gaps = 20/273 (7%)

Query: 289 EYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILIS 348
           ++  VP    CG R   +   R+ GG  A     PWQ ++        G R  CG  ++ 
Sbjct: 482 DWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSL------KEGSRHFCGATVVG 535

Query: 349 SCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIA 408
             W+LSAAHCF        +   LG    +  G    K  + + ++H  ++    D D+A
Sbjct: 536 DRWLLSAAHCFNHT-KVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLA 594

Query: 409 LLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHV 468
           +L+L S  +     +  ++ VCLP A  + P   +C +SG+G  +  +    E L++A V
Sbjct: 595 VLELASPLAF----NKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASV 650

Query: 469 RLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN-DGRMTL 527
            +     C+   L N ++TD M+CAG            D+CQGDSGGPL C    G   L
Sbjct: 651 GIIDQKTCSV--LYNFSLTDRMICAGFLEGKV------DSCQGDSGGPLACEEAPGVFYL 702

Query: 528 VGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNM 560
            GI+SWG+GC Q   PGVYT++T    WI + M
Sbjct: 703 AGIVSWGIGCAQVKKPGVYTRITRLKGWILEIM 735



 Score =  140 bits (352), Expect = 4e-33
 Identities = 93/277 (33%), Positives = 133/277 (48%), Gaps = 29/277 (10%)

Query: 292  DVPSCST------CGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGI 345
            D P  +T      CGL   +    RI GG  A     PWQ +++ + R        CG +
Sbjct: 804  DAPEATTHTQLPDCGLAPAALT--RIVGGSAAGRGEWPWQVSLWLRRREHR-----CGAV 856

Query: 346  LISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDN 405
            L++  W+LSAAHCF     P      LG  +  + G E Q   V +   H  ++  T D 
Sbjct: 857  LVAERWLLSAAHCFDVYGDPKQWAAFLGTPF--LSGAEGQLERVARIYKHPFYNLYTLDY 914

Query: 406  DIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKE 465
            D+ALL+L     R    S +VR +CLP    + PD T C ++G+G         + +L++
Sbjct: 915  DVALLELAGPVRR----SRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSM-ARQLQK 969

Query: 466  AHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN-DGR 524
            A VRL     C   + +   ++  MLCAG  + G       D+C GD+GGPL C    GR
Sbjct: 970  AAVRLLSEQTCRRFYPVQ--ISSRMLCAGFPQGGV------DSCSGDAGGPLACREPSGR 1021

Query: 525  MTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
              L G+ SWG GCG+   PGVYT+V     WI  +++
Sbjct: 1022 WVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQ 1058


>gi|148806900 epidermis-specific serine protease-like protein [Homo
           sapiens]
          Length = 328

 Score =  144 bits (364), Expect = 2e-34
 Identities = 96/269 (35%), Positives = 134/269 (49%), Gaps = 32/269 (11%)

Query: 297 STCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAA 356
           S CG   YS    R+ GG  A     PWQ ++   H       F+CGG L+S   IL+AA
Sbjct: 17  SVCGQPVYSS---RVVGGQDAAAGRWPWQVSLHFDHN------FICGGSLVSERLILTAA 67

Query: 357 HCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDS 416
           HC Q  +     TV LG +  V    +  K+ V K ++H ++ D T D  +ALL+L S  
Sbjct: 68  HCIQPTWTTFSYTVWLG-SITVGDSRKRVKYYVSKIVIHPKYQDTTAD--VALLKLSSQV 124

Query: 417 SRCAQESSVVRTVCLPPADLQLPDWTECELSGYGK-HEALSPFYSERLKEAHVRLYPSSR 475
           +     +S +  +CLP    QL     C ++G+GK  E+    Y   L+EA V +     
Sbjct: 125 TF----TSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQA 180

Query: 476 CTSQH--------LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTL 527
           C   +         L   + ++ +CAGDT+      N+ D+C+GDSGGPL C  DG    
Sbjct: 181 CEQLYNPIGIFLPALEPVIKEDKICAGDTQ------NMKDSCKGDSGGPLSCHIDGVWIQ 234

Query: 528 VGIISWGLGCGQKDVPGVYTKVTNYLDWI 556
            G++SWGL CG K +PGVYT V  Y  WI
Sbjct: 235 TGVVSWGLECG-KSLPGVYTNVIYYQKWI 262


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  144 bits (362), Expect = 3e-34
 Identities = 97/269 (36%), Positives = 138/269 (51%), Gaps = 23/269 (8%)

Query: 296 CSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSA 355
           C  CG+   S  Q RI GG  A   + PWQ ++  ++        +CGG +I+  WI++A
Sbjct: 278 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVH------VCGGSIITPEWIVTA 331

Query: 356 AHCFQERFP-PHHLTVILG--RTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQL 412
           AHC ++    P H T   G  R   +  G     ++VEK I H  +D  T +NDIAL++L
Sbjct: 332 AHCVEKPLNNPWHWTAFAGILRQSFMFYGAG---YQVEKVISHPNYDSKTKNNDIALMKL 388

Query: 413 KSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYP 472
           +   +     + +V+ VCLP   + L     C +SG+G  E      SE L  A V L  
Sbjct: 389 QKPLTF----NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKT-SEVLNAAKVLLIE 443

Query: 473 SSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIIS 532
           + RC S+++ +  +T  M+CAG       Q N+ D+CQGDSGGPLV   +    L+G  S
Sbjct: 444 TQRCNSRYVYDNLITPAMICAGFL-----QGNV-DSCQGDSGGPLVTSKNNIWWLIGDTS 497

Query: 533 WGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
           WG GC +   PGVY  V  + DWI   MR
Sbjct: 498 WGSGCAKAYRPGVYGNVMVFTDWIYRQMR 526


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  144 bits (362), Expect = 3e-34
 Identities = 97/269 (36%), Positives = 138/269 (51%), Gaps = 23/269 (8%)

Query: 296 CSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSA 355
           C  CG+   S  Q RI GG  A   + PWQ ++  ++        +CGG +I+  WI++A
Sbjct: 241 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVH------VCGGSIITPEWIVTA 294

Query: 356 AHCFQERFP-PHHLTVILG--RTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQL 412
           AHC ++    P H T   G  R   +  G     ++VEK I H  +D  T +NDIAL++L
Sbjct: 295 AHCVEKPLNNPWHWTAFAGILRQSFMFYGAG---YQVEKVISHPNYDSKTKNNDIALMKL 351

Query: 413 KSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYP 472
           +   +     + +V+ VCLP   + L     C +SG+G  E      SE L  A V L  
Sbjct: 352 QKPLTF----NDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKT-SEVLNAAKVLLIE 406

Query: 473 SSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIIS 532
           + RC S+++ +  +T  M+CAG       Q N+ D+CQGDSGGPLV   +    L+G  S
Sbjct: 407 TQRCNSRYVYDNLITPAMICAGFL-----QGNV-DSCQGDSGGPLVTSKNNIWWLIGDTS 460

Query: 533 WGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
           WG GC +   PGVY  V  + DWI   MR
Sbjct: 461 WGSGCAKAYRPGVYGNVMVFTDWIYRQMR 489


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  142 bits (359), Expect = 6e-34
 Identities = 94/269 (34%), Positives = 134/269 (49%), Gaps = 29/269 (10%)

Query: 297 STCGLRQYSQ---------PQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILI 347
           S CG+R  S           Q  ++G   A     PWQA++     +  G    CG  LI
Sbjct: 184 SRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASL-----QLIGSGHQCGASLI 238

Query: 348 SSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDI 407
           S+ W+L+AAHCF +   P       G T  + P     K  V K I+H+ +  +T +NDI
Sbjct: 239 SNTWLLTAAHCFWKNKDPTQWIATFGAT--ITP--PAVKRNVRKIILHENYHRETNENDI 294

Query: 408 ALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAH 467
           AL+QL +      + S++V+ VCLP + ++LP  T   ++G+G      P  +  L++A 
Sbjct: 295 ALVQLSTG----VEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNT-LRQAR 349

Query: 468 VRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTL 527
           V    +  C  + + +  +T  MLCAG            DAC+GDSGGPLV  N     +
Sbjct: 350 VETISTDVCNRKDVYDGLITPGMLCAGFMEGK------IDACKGDSGGPLVYDNHDIWYI 403

Query: 528 VGIISWGLGCGQKDVPGVYTKVTNYLDWI 556
           VGI+SWG  C     PGVYT+VT Y DWI
Sbjct: 404 VGIVSWGQSCALPKKPGVYTRVTKYRDWI 432


>gi|11496281 kallikrein 13 precursor [Homo sapiens]
          Length = 277

 Score =  141 bits (355), Expect = 2e-33
 Identities = 99/258 (38%), Positives = 140/258 (54%), Gaps = 37/258 (14%)

Query: 311 IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTV 370
           + GG      S PWQAA+  + R       LCGG+L+   W+L+AAHC +E      L V
Sbjct: 36  LPGGYTCFPHSQPWQAALLVQGR------LLCGGVLVHPKWVLTAAHCLKEG-----LKV 84

Query: 371 ILGRTY--RVVPGEEEQKFEVEKYIVHKEFDDD----TYDNDIALLQLKSDSSRCAQESS 424
            LG+    RV  GE+ +  EV   I H E+        +D+DI LL+L+S      Q + 
Sbjct: 85  YLGKHALGRVEAGEQVR--EVVHSIPHPEYRRSPTHLNHDHDIMLLELQSP----VQLTG 138

Query: 425 VVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNR 484
            ++T+ L   +   P  T C +SG+G   +    Y + L+ A+++L     C  + +   
Sbjct: 139 YIQTLPLSHNNRLTPG-TTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEEC--RQVYPG 195

Query: 485 TVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWG-LGCGQKDVP 543
            +TDNMLCAG T+ GG      D+C+GDSGGPLVC      TL GI+SWG   CGQ D P
Sbjct: 196 KITDNMLCAG-TKEGGK-----DSCEGDSGGPLVC----NRTLYGIVSWGDFPCGQPDRP 245

Query: 544 GVYTKVTNYLDWIRDNMR 561
           GVYT+V+ Y+ WIR+ +R
Sbjct: 246 GVYTRVSRYVLWIRETIR 263


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  141 bits (355), Expect = 2e-33
 Identities = 94/264 (35%), Positives = 129/264 (48%), Gaps = 17/264 (6%)

Query: 297 STCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAA 356
           + CG  + S    RI GG        PWQA+I  +HR +     +CGG LI+  W+L+AA
Sbjct: 26  AACGQPRMSS---RIVGGRDGRDGEWPWQASI--QHRGA----HVCGGSLIAPQWVLTAA 76

Query: 357 HCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDS 416
           HCF  R  P    V LG               V + ++  ++ +D    D+ALLQL+   
Sbjct: 77  HCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLR--- 133

Query: 417 SRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSER-LKEAHVRLYPSSR 475
            R    S+ V+ VCLP    + P  T C ++G+G      P    R L+   V L  S  
Sbjct: 134 -RPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRT 192

Query: 476 CTSQHLLNRTV--TDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISW 533
           C   + +   V   + ++  G   +G PQ +  DACQGDSGGPL CL  G   LVG++SW
Sbjct: 193 CDGLYHVGADVPQAERIVLPGSLCAGYPQGH-KDACQGDSGGPLTCLQSGSWVLVGVVSW 251

Query: 534 GLGCGQKDVPGVYTKVTNYLDWIR 557
           G GC   + PGVYT V  Y  WI+
Sbjct: 252 GKGCALPNRPGVYTSVATYSPWIQ 275


>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
          Length = 352

 Score =  141 bits (355), Expect = 2e-33
 Identities = 100/271 (36%), Positives = 137/271 (50%), Gaps = 37/271 (13%)

Query: 297 STCGLRQYSQPQFR---IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWIL 353
           S CG R   + + R   I GG+ A++   PWQ +I A+      E F CGG +++  WIL
Sbjct: 51  SECGDRSIFEGRTRYSRITGGMEAEVGEFPWQVSIQAR-----SEPF-CGGSILNKWWIL 104

Query: 354 SAAHC-FQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQL 412
           +AAHC + E   P  L+V+LG      P  E +  EV   I+HK+F     DNDIALL L
Sbjct: 105 TAAHCLYSEELFPEELSVVLGTNDLTSPSMEIK--EVASIILHKDFKRANMDNDIALLLL 162

Query: 413 KSDSSRCAQESSVVRTVCLP----PADLQLPDWTECELSGYGKHEALSP-FYSERLKEAH 467
            S      +   +   +CLP    PA      W EC ++G+G+  A         L +A 
Sbjct: 163 ASP----IKLDDLKVPICLPTQPGPAT-----WRECWVAGWGQTNAADKNSVKTDLMKAP 213

Query: 468 VRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDG--RM 525
           + +     C+        +T NMLCAG           +DAC+GDSGGPLVC  +   + 
Sbjct: 214 MVIMDWEECSKMF---PKLTKNMLCAGYKNES------YDACKGDSGGPLVCTPEPGEKW 264

Query: 526 TLVGIISWGLGCGQKDVPGVYTKVTNYLDWI 556
             VGIISWG  CG+K+ PG+YT + NY  WI
Sbjct: 265 YQVGIISWGKSCGEKNTPGIYTSLVNYNLWI 295


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  139 bits (351), Expect = 5e-33
 Identities = 88/261 (33%), Positives = 133/261 (50%), Gaps = 22/261 (8%)

Query: 297 STCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAA 356
           ++CG R       RI  G+ A  A+ PWQA++   +         CG  LIS+ W+++AA
Sbjct: 173 ASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQ------CGATLISNTWLVTAA 226

Query: 357 HCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDS 416
           HCFQ+   PH  TV  G   ++ P     K  V ++I+H+++     + DIA++Q+ S  
Sbjct: 227 HCFQKYKNPHQWTVSFGT--KINP--PLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRV 282

Query: 417 SRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRC 476
           +     S  +R +CLP A           ++G+G         ++ L+EA V++     C
Sbjct: 283 TF----SDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQND-LREARVKIISDDVC 337

Query: 477 TSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN-DGRMTLVGIISWGL 535
               +    +   M CAG          ++DAC+GDSGGPLV  +      L+GI+SWG 
Sbjct: 338 KQPQVYGNDIKPGMFCAGYMEG------IYDACRGDSGGPLVTRDLKDTWYLIGIVSWGD 391

Query: 536 GCGQKDVPGVYTKVTNYLDWI 556
            CGQKD PGVYT+VT Y +WI
Sbjct: 392 NCGQKDKPGVYTQVTYYRNWI 412


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.457 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,358,333
Number of Sequences: 37866
Number of extensions: 1250503
Number of successful extensions: 4260
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 200
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 2577
Number of HSP's gapped (non-prelim): 909
length of query: 562
length of database: 18,247,518
effective HSP length: 107
effective length of query: 455
effective length of database: 14,195,856
effective search space: 6459114480
effective search space used: 6459114480
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.