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Search of human proteins with 4505573
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
(646 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 1300 0.0
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 1300 0.0
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 1125 0.0
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 1125 0.0
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 1125 0.0
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 804 0.0
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 132 8e-31
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 132 1e-30
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 122 8e-28
gi|71274148 pleckstrin homology domain containing, family G (wit... 117 4e-26
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 109 7e-24
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 106 8e-23
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 106 8e-23
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 103 6e-22
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 99 2e-20
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 96 1e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 96 1e-19
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 87 6e-17
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 86 1e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 79 1e-14
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 79 1e-14
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 79 2e-14
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 78 2e-14
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 78 2e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 78 2e-14
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 78 2e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 78 2e-14
gi|39930351 dynamin binding protein [Homo sapiens] 74 3e-13
gi|55749621 pleckstrin homology domain containing, family G, mem... 73 7e-13
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 72 2e-12
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1300 bits (3365), Expect = 0.0
Identities = 646/646 (100%), Positives = 646/646 (100%)
Query: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600
AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE
Sbjct: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600
Query: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646
VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
Sbjct: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 1300 bits (3365), Expect = 0.0
Identities = 646/646 (100%), Positives = 646/646 (100%)
Query: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
Query: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
Query: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600
AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE
Sbjct: 541 AYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDE 600
Query: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646
VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
Sbjct: 601 VQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL 646
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 129 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 188
Query: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 189 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 248
Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 249 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 308
Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 309 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 368
Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 369 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 428
Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 429 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 488
Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 489 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 548
Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 549 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 608
Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 609 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 668
Query: 541 AYCTSAKTRQTLNSS 555
AYCTSAKTRQTLNS+
Sbjct: 669 AYCTSAKTRQTLNST 683
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 179 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 238
Query: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 239 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 298
Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 299 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 358
Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 359 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 418
Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 419 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 478
Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 479 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 538
Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 539 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 598
Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 599 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 658
Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 659 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 718
Query: 541 AYCTSAKTRQTLNSS 555
AYCTSAKTRQTLNS+
Sbjct: 719 AYCTSAKTRQTLNST 733
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 1125 bits (2911), Expect = 0.0
Identities = 554/555 (99%), Positives = 555/555 (100%)
Query: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 158 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 217
Query: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL
Sbjct: 218 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 277
Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK
Sbjct: 278 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 337
Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK
Sbjct: 338 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 397
Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG
Sbjct: 398 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 457
Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED
Sbjct: 458 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 517
Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP
Sbjct: 518 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 577
Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA
Sbjct: 578 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 637
Query: 481 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 540
PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE
Sbjct: 638 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIE 697
Query: 541 AYCTSAKTRQTLNSS 555
AYCTSAKTRQTLNS+
Sbjct: 698 AYCTSAKTRQTLNST 712
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 804 bits (2077), Expect = 0.0
Identities = 405/645 (62%), Positives = 503/645 (77%), Gaps = 44/645 (6%)
Query: 1 MTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
MT+N ++QL+V+A+FNF+QTNEDELS KGD+I+VTRVEEGGWWEGTLNGRTGWFPSNYV
Sbjct: 155 MTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYV 214
Query: 61 REVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYL 120
RE+K+SE+P+SPK+ KGF+T + K+YY VVLQNIL+TE EY+KELQ++L TYL
Sbjct: 215 REIKSSERPLSPKA------VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYL 268
Query: 121 RPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMK 180
RPLQ++ LS+ ++ L+GN EE+C+FQQ L Q+LEEC+K PE Q +VGGC L+LMP K
Sbjct: 269 RPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFK 328
Query: 181 TLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLK 240
++YL YCANHPSAVNVLT+HS+EL +FME +GASSPGIL+LTT LSKPFMRL+KY TLL+
Sbjct: 329 SMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQ 388
Query: 241 ELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLG 300
ELERHMED H D QDI K++ AFK L QCQ++RKRK+LELQIL+E I+ WEG+DIK LG
Sbjct: 389 ELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLG 448
Query: 301 NVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLED 360
NV +MSQV++Q EEK ERYL+LF NVL+MLSASPRMSGFIYQGK+P G +T+L++
Sbjct: 449 NVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDE 508
Query: 361 SENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLP 420
E + FEI+G+ +ERI+V CNN QD QEW+E L + +
Sbjct: 509 IEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIR-------------------- 548
Query: 421 SHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPA 480
P+S + SK + + + H+ S G P GPLEPP+ KPWSLSCLRPA
Sbjct: 549 ----GPASCSSLSKTSSSSCSAHS--SFSSTGQPR-----GPLEPPQIIKPWSLSCLRPA 597
Query: 481 PPLRPSAALCYKE-------DLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDA 533
PPLRPSAAL YKE + SKSPKTMKK L KRK ERKPS+EE+ RKSTAALEEDA
Sbjct: 598 PPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDA 657
Query: 534 QILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDT 593
QILKVIEAYCTSA +Q SS+RK+S PQVLLPEEEK+I+EET+SNGQT++EEKSLVDT
Sbjct: 658 QILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDT 717
Query: 594 VYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMND 638
VYALKDEV+EL+Q+NK+MK+ LEEE ++R+DLEKLVR++LK ++
Sbjct: 718 VYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDE 762
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 132 bits (333), Expect = 8e-31
Identities = 118/484 (24%), Positives = 208/484 (42%), Gaps = 28/484 (5%)
Query: 21 NEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTL 77
++ EL F GDVI V WW G + GWFP+++VR ++P +P +G
Sbjct: 209 DDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNS 268
Query: 78 KSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISY 136
+ G + + V+ IL TE +Y K L+ + Y+R + ++ S +
Sbjct: 269 GAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRT 328
Query: 137 LMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA-- 193
+ GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A
Sbjct: 329 IFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACV 387
Query: 194 -VNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD 252
++ LT+ S+ + F + + L L P ++ KYP L EL ++ H D
Sbjct: 388 ELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
Query: 253 RQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLI 310
+D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L
Sbjct: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT 507
Query: 311 QCAGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH---- 364
+ + K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 508 RVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHV 567
Query: 365 --RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPS 421
+NAF + G+ + L+ + Q W++ ++ + + T S+
Sbjct: 568 SIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET--GFSITELQRKQ 625
Query: 422 HPVTPSSKHADSKPAPL-TPAYHTLPHPSHHGTPHTTINWGPL---EPPKTPKPWSLSCL 477
+ S + KP + P Y L H P L EP + P + S
Sbjct: 626 AMLNASKQQVTGKPKAVGRPCY--LTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSIS 683
Query: 478 RPAP 481
R AP
Sbjct: 684 RLAP 687
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 132 bits (332), Expect = 1e-30
Identities = 101/407 (24%), Positives = 185/407 (45%), Gaps = 20/407 (4%)
Query: 21 NEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV---SPKSGTL 77
++ EL F GDVI V WW G + GWFP+++VR ++P +P +G
Sbjct: 209 DDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNS 268
Query: 78 KSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSSANISY 136
+ G + + V+ IL TE +Y K L+ + Y+R + ++ S +
Sbjct: 269 GAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRT 328
Query: 137 LMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANHPSA-- 193
+ GN+E+I Q+ V++LE+ +G CFL + +Y YC NHP+A
Sbjct: 329 IFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNACV 387
Query: 194 -VNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTD 252
++ LT+ S+ + F + + L L P ++ KYP L EL ++ H D
Sbjct: 388 ELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
Query: 253 RQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLI 310
+D++ ++ A KN++ E ++R E ++ +I +WEG+D+ + S L
Sbjct: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELT 507
Query: 311 QCAGSEEKN-ERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENH---- 364
+ + K+ +R LF + L+ R Y+G+L G+ + LED ++
Sbjct: 508 RVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHV 567
Query: 365 --RNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPT 408
+NAF + G+ + L+ + Q W++ ++ + + T
Sbjct: 568 SIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 122 bits (307), Expect = 8e-28
Identities = 103/413 (24%), Positives = 178/413 (43%), Gaps = 26/413 (6%)
Query: 4 NSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63
+ N + A ++ ++ EL F GDVI V WW G + WFP+++VR +
Sbjct: 145 SDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR-L 203
Query: 64 KASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETENEYSKELQTVL 116
+ +++ +S S + S + + + NK V++ I++TE Y K L+ +
Sbjct: 204 RVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDIC 263
Query: 117 STYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLN 174
Y+R + + + A ++ + GN+E+I FQ+ ++ LE+ E +G CFL
Sbjct: 264 EGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQ 323
Query: 175 LMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLTTG-LSKPFMR 231
+Y YC NHP A L ++ F E I + G L P +
Sbjct: 324 NQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQK 382
Query: 232 LDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTE---AI 288
+ KYP L EL ++ H D +I+ + A KN++ E RKRK + + +I
Sbjct: 383 ICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESIDKIARWQVSI 441
Query: 289 RNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGK 347
WEG DI + S L + + +R LF + L+ R Y+G+
Sbjct: 442 VGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGR 501
Query: 348 LPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQEWVE 393
L M + L D + +NAF++ + + + C Q+D W++
Sbjct: 502 LDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 554
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 117 bits (292), Expect = 4e-26
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 93 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 150
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Query: 151 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 208
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
Query: 209 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 268
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
Query: 269 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 326
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
Query: 327 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 385
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
Query: 386 QDLQEWVEHLQK 397
QD + WV HL++
Sbjct: 402 QDKRLWVLHLKR 413
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 109 bits (273), Expect = 7e-24
Identities = 96/405 (23%), Positives = 170/405 (41%), Gaps = 31/405 (7%)
Query: 24 ELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR-----EVKASEKPVSPKSGTLK 78
EL+F GDVI V WW G ++ GWFP+++VR E + E P ++G L
Sbjct: 26 ELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHL- 84
Query: 79 SPPKGFDTTAINKSYYN------VVLQNILETENEYSKELQTVLSTYLRPL-QTSEKLSS 131
D + + N V+ I+ TE Y K L+ + YL+ + + S
Sbjct: 85 --DPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSD 142
Query: 132 ANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLNLMPQMKTLYLTYCANH 190
+ + GN+E+I FQ V+ LE+ + +G CFL +Y YC NH
Sbjct: 143 EQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNH 201
Query: 191 PSAVNVLTE--HSEELGEFMETKGASSPGILVLTTG-LSKPFMRLDKYPTLLKELERHME 247
A L++ F E I + G L P ++ KYP L EL ++
Sbjct: 202 LDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTA 261
Query: 248 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDI-KTLGNVTY 304
H+D + + ++A +N++ Q E ++R E ++ ++ +WEG+DI + Y
Sbjct: 262 QDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
Query: 305 MSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSEN 363
++ +R LF + +++ R Y+G++ + +ED +
Sbjct: 322 TGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRD 381
Query: 364 H------RNAFEISGSMIERI-LVSCNNQQDLQEWVEHLQKQTKV 401
+NAF++ E I L ++ W+ +++ K+
Sbjct: 382 DDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKM 426
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 106 bits (264), Expect = 8e-23
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
Query: 71 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
Query: 131 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
Query: 188 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
Query: 244 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 12 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 68 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101
K VSPK L S P + A Y NV N+
Sbjct: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
Query: 73 KSGTLKSPPK 82
KSG P+
Sbjct: 1020 KSGASNKKPE 1029
Score = 47.4 bits (111), Expect = 4e-05
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 9 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 106 bits (264), Expect = 8e-23
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
Query: 71 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
Query: 131 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
Query: 188 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
Query: 244 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
+ + H D ++ ++ + L +Q E + KE
Sbjct: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
Score = 64.7 bits (156), Expect = 3e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 12 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 68 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101
K VSPK L S P + A Y NV N+
Sbjct: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
Score = 48.1 bits (113), Expect = 2e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
Query: 73 KSGTLKSPPK 82
KSG P+
Sbjct: 1047 KSGASNKKPE 1056
Score = 47.4 bits (111), Expect = 4e-05
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 9 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 103 bits (256), Expect = 6e-22
Identities = 66/271 (24%), Positives = 131/271 (48%), Gaps = 13/271 (4%)
Query: 15 FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKS 74
+++ N+DEL+F+KG +I+V E+ WW+G +NG+ G FPSNYV+ + P
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK-LTTDMDPSQQWC 1222
Query: 75 GTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI 134
L T + Y + ++ TE Y +LQ V + +PL SE L+ +
Sbjct: 1223 SDLHLLDMLTPTERKRQGY----IHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEV 1278
Query: 135 SYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYCANHP 191
+ + N +E+ L+++L K+ + + +G +P M+ Y+ +C+
Sbjct: 1279 AMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQP-YIRFCSRQL 1337
Query: 192 SAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELERHME 247
+ ++ + ++E +F E + A P + L++ + KP R+ +YP ++K + +
Sbjct: 1338 NGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTP 1397
Query: 248 DYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
+ H D ++ ++ + L +Q E + KE
Sbjct: 1398 ENHPDHSHLKHALEKAEELCSQVNEGVREKE 1428
Score = 58.2 bits (139), Expect = 2e-08
Identities = 26/70 (37%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
A + ++ + + +L+F +GDVI VT+ ++G WW GT+ + G FPSNYVR + +
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 73 KSGTLKSPPK 82
K+G+L P+
Sbjct: 1068 KTGSLGKKPE 1077
Score = 55.1 bits (131), Expect = 2e-07
Identities = 26/78 (33%), Positives = 43/78 (55%), Gaps = 9/78 (11%)
Query: 12 RAKFNFQQTNEDELSFSKGDVIHV-------TRVEEGGWWEGTLNGRTGWFPSNYVREVK 64
RA + F+ + DE++ GD++ V ++ E GW G L G+TGWFP+NY ++
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 65 ASE--KPVSPKSGTLKSP 80
+E PV P + + +P
Sbjct: 806 ENEVPAPVKPVTDSTSAP 823
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 12/92 (13%)
Query: 16 NFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGR-----TGWFPSNYVREVKASEKPV 70
++ T ++L+ + G +I + + GGWWEG L R GWFP+NYV+ + +
Sbjct: 1084 SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKI 1143
Query: 71 SPKSGTLKSPPKGFDTTAINK--SYYNVVLQN 100
+P PPK A+ + Y+ QN
Sbjct: 1144 TP-----TEPPKSTALAAVCQVIGMYDYTAQN 1170
Score = 49.7 bits (117), Expect = 8e-06
Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 2/73 (2%)
Query: 9 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKAS-E 67
L +A + ++ ++ L+F+K DVI V ++ WW G + G+ GWFP +YV+ +
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLE-QQDMWWFGEVQGQKGWFPKSYVKLISGPIR 974
Query: 68 KPVSPKSGTLKSP 80
K S SG+ +SP
Sbjct: 975 KSTSMDSGSSESP 987
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 98.6 bits (244), Expect = 2e-20
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 33/306 (10%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTS------EKLSSANISYLMGNLEEICSFQQM 150
VL IL TE +Y L+ + S +L ++ + + L+ N+ L N+E+I +
Sbjct: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
Query: 151 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 207
+ +LE C P++Q +G FL + +Y YC+NH A+ +L E ++ + F
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVELNKIPTVRAF 171
Query: 208 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
+ + G + L L P R+ KYP LLKEL + H D +Q ++ A K
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
Query: 265 NLSAQCQEVRKRKE-LE-LQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERY 322
+ + E +++ E LE L+ L I WEG ++ + + L++ + + ER
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ-ERA 290
Query: 323 LLLFPNVLLMLSASPRMSG---------------FIYQGKLPTTGMTITKLED--SENHR 365
LF N+L+ R++G +I++G++ T M + +ED ++ H
Sbjct: 291 FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHS 350
Query: 366 NAFEIS 371
N + ++
Sbjct: 351 NGYTVT 356
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 95.5 bits (236), Expect = 1e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 150
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 151 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 207
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 208 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 265 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 321
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 322 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 364
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 365 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 398
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 95.5 bits (236), Expect = 1e-19
Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 150
VL + +TE +Y L+ ++S +L + + + ++ + L N+E+I + +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 151 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 207
++ +EEC P AQQ VG CFL+ + + +Y YC+NH A +L E ++ + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 208 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
+ G + L L P R+ KYP +LKEL + H+D + +++ A K
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 265 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 321
+ + E +++ E +L++L E I WEG +I M VL++ + S ER
Sbjct: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
Query: 322 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 364
LF N+L+ AS ++++G++ T M + ++D S H
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
Query: 365 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 398
N ++I + + V ++ EW E + K+
Sbjct: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 86.7 bits (213), Expect = 6e-17
Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 20/373 (5%)
Query: 90 NKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQ 149
+K+Y+ + + + TE Y K+L+ + S + + + + A S + N E + F
Sbjct: 539 DKAYF--IAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHT 596
Query: 150 MLVQSLEECTKLPEAQ--------QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---T 198
++ +E+ L E + QR+G L + MK L + H A+ L
Sbjct: 597 NFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHL-AAHLWKHSEALEALENGI 655
Query: 199 EHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQK 258
+ S L F L L T L +P RL Y +L+ L +H H D +D +
Sbjct: 656 KSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRA 715
Query: 259 SMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEK 318
++A + AQ + E Q L E ++ G D + ++ + +
Sbjct: 716 ALAEITEMVAQLHGTMIKME-NFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGL 774
Query: 319 NERYLLLFPNVLLMLSASPRMSG-FIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIER 377
+R LF +VLL S S F G+LP GMTI + ED + + G +
Sbjct: 775 QQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQR-QS 833
Query: 378 ILVSCNNQQDLQEWVEHLQKQ---TKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 434
I+V+ +++ ++++WVE +Q + +S P S P + P + D
Sbjct: 834 IIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDL 893
Query: 435 PAPLTPAYHTLPH 447
A T PH
Sbjct: 894 SASRTSLERQAPH 906
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 85.5 bits (210), Expect = 1e-16
Identities = 76/313 (24%), Positives = 145/313 (46%), Gaps = 22/313 (7%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTSEKL--SSANISYLMGNLEEICSFQQMLVQS 154
V + I+ETE Y ++L++++ YL PL L S + L N+E+I F L++
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165
Query: 155 LEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFMETKG 212
LE + + + CF+ +Y YC N+PS++ +L E S +++ +
Sbjct: 166 LENSS----SAGGIAECFVQRSEDFD-IYTLYCMNYPSSLALLRELSLSPPAALWLQERQ 220
Query: 213 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMED--YHTDRQDIQKSMAAFKNLSAQC 270
A L L + L KP R+ KY LL+EL +H + R+ +++++ + ++
Sbjct: 221 AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYI 280
Query: 271 QEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSE--EKNERYLLLF 326
++++++E LQ + + W G ++ G + G ER L LF
Sbjct: 281 NDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLF 340
Query: 327 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMI--ERILVSCNN 384
+LL+ A R + Y+G + ++++ +S F++S I R L+ N
Sbjct: 341 SRMLLV--AKRRGLEYTYKGHIFCCNLSVS---ESPRDPLGFKVSDLTIPKHRHLLQAKN 395
Query: 385 QQDLQEWVEHLQK 397
Q++ + W+ LQ+
Sbjct: 396 QEEKRLWIHCLQR 408
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 79.3 bits (194), Expect = 1e-14
Identities = 80/348 (22%), Positives = 152/348 (43%), Gaps = 16/348 (4%)
Query: 62 EVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLST-YL 120
E K E+ L+ + + N+ + + +L TE Y L + Y
Sbjct: 175 ETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYC 234
Query: 121 RPLQTSEKLS--SANISYLMGNLEEICSFQ-QMLVQSLEECTKLPEAQQRVGGCFLNLMP 177
+ L+ + + S + ++ + N+ I +F + L+ LE+ + E R+G L P
Sbjct: 235 KLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAP 294
Query: 178 QMKTLYLTYCANHPSAVNVLTEHSEELGEFM----ETKGASSPGILVLTTGLSKPFMRLD 233
+K +Y Y +A+ ++ +E + +F E + G L L + +P R+
Sbjct: 295 FLK-MYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIP 353
Query: 234 KYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE-VRKRKELELQILTEAIRNWE 292
+Y LLK+ R + D D +KS+ ++ +RK + L+ + + E
Sbjct: 354 RYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEE 413
Query: 293 GDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSG--FIYQGKLPT 350
D + + Q+L A + ERYL LF N+LL + G F + ++
Sbjct: 414 EDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGI 473
Query: 351 TGMTITKLEDSENHRNAFEISGSMIERIL-VSCNNQQDLQEWVEHLQK 397
GM I + + +E + + F++SG ER L + ++ QD +EW++ LQ+
Sbjct: 474 DGMKIVETQ-NEEYPHTFQVSGK--ERTLELQASSAQDKEEWIKALQE 518
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 79.0 bits (193), Expect = 1e-14
Identities = 77/340 (22%), Positives = 145/340 (42%), Gaps = 18/340 (5%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 156
+++ IL TE Y K+L+ + + + + + + ++ L N++ I F + ++ +E
Sbjct: 539 IVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVE 598
Query: 157 ECTKLPE---------AQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL---TEHSEEL 204
+ L E + QR+G L M Q+K + +Y H + L T+ ++L
Sbjct: 599 QRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKE-FTSYFQRHDEVLTELEKATKRCKKL 657
Query: 205 GEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264
+ L L T L KP RL Y LL+ L H H D D ++ A
Sbjct: 658 EAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAIT 717
Query: 265 NLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLL 324
++ Q + R E LQ LTE R+ G + ++ + + + +R
Sbjct: 718 EVTTTLQHILIRLE-NLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFF 776
Query: 325 LFPNVLLMLSAS-PRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCN 383
LF ++LL S S F +G LP GM + + ++ + + F I + + I+V+ +
Sbjct: 777 LFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQ-KTIVVAAS 835
Query: 384 NQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP 423
+ + ++W+ L + G T ++P T+ + P
Sbjct: 836 TRLEKEKWMLDLNSAIQAAKSGGDTAP--ALPGRTVCTRP 873
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 78.6 bits (192), Expect = 2e-14
Identities = 75/322 (23%), Positives = 154/322 (47%), Gaps = 50/322 (15%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTS-EKLSSANIS---YLMGNLEEICSFQQ-ML 151
++ +++TE Y ++L+ + TYL + + E++ ++ + GN++EI F +
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIF 1355
Query: 152 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS-EELGEFMET 210
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1356 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSTQLILEHAGSYFDEIQQR 1411
Query: 211 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAA-------- 262
G ++ +++ L KP R+ KY LLKEL E+ + +D + M +
Sbjct: 1412 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDA 1467
Query: 263 --FKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNE 320
L + + + EL IL E+ + W D KTL + E
Sbjct: 1468 MHLSMLEGFDENIESQGEL---ILQESFQVW---DPKTL---------------IRKGRE 1506
Query: 321 RYLLLFPNVLLM---LSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEI--SGSMI 375
R+L LF L+ + S S ++Y+ KL T+ + +T+ + + + A + + +
Sbjct: 1507 RHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSD 1566
Query: 376 ERILVSCNNQQDLQEWVEHLQK 397
+I++ ++ ++ Q+W++H+++
Sbjct: 1567 NKIVLKASSIENKQDWIKHIRE 1588
Score = 70.9 bits (172), Expect = 4e-12
Identities = 75/361 (20%), Positives = 161/361 (44%), Gaps = 38/361 (10%)
Query: 56 PSNYVREVKASEKP-VSPKSGTLKSPPKGFD------TTAINKSYYNVVLQNILETENEY 108
PS+ + + S P +P +L S D ++++ + +Y VLQ ++ETE +Y
Sbjct: 1927 PSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHY--VLQELVETERDY 1984
Query: 109 SKELQTVLSTYLRPLQTSEKLSS--ANISYLMGNLEEICSFQQ-MLVQSLEECTKLPEAQ 165
++L V+ Y+ ++ + GN+ +I + + + LE+C + PE
Sbjct: 1985 VRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE-- 2042
Query: 166 QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGL 225
++G F+ ++ +Y+ YC N P + ++++E+ + E ++ + L LT L
Sbjct: 2043 -KLGSLFVKHERRLH-MYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHR---LQLTDLL 2097
Query: 226 SKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILT 285
KP R+ KY LLK+ ++ + D ++++++ + +C ++ L+
Sbjct: 2098 IKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQ----- 2152
Query: 286 EAIRNWEGDDIKTLGNVTYMSQVLI--QCAGSEEK-NERYLLLFPNVLLMLSASPRMSGF 342
++G I G + L+ Q AG + ER + LF +++ + GF
Sbjct: 2153 ----GFDG-KIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGF 2207
Query: 343 IYQGKLPTTGMTITKL---EDSENHRNAFEI---SGSMIERILVSCNNQQDLQEWVEHLQ 396
G L + ++ L E+ EN F + +G ++E ++ ++ Q W+ +
Sbjct: 2208 SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEIN 2267
Query: 397 K 397
+
Sbjct: 2268 Q 2268
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 78.2 bits (191), Expect = 2e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 151
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 152 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 210
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 211 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 270
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 271 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 323
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 324 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 378
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 379 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 434
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
Score = 64.7 bits (156), Expect = 3e-10
Identities = 86/403 (21%), Positives = 171/403 (42%), Gaps = 52/403 (12%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTS---EKLSSANISYLMGNLEEICSFQQ-MLV 152
VL +++TE +Y K+L V+ +++ ++ E + + + GN+ +I + + +
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKD-KIVFGNIHQIYDWHKDFFL 1991
Query: 153 QSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKG 212
LE+C + Q R+ F+ ++ +Y+ YC N P + ++ E+ E +
Sbjct: 1992 AELEKCI---QEQDRLAQLFIKHERKLH-IYVWYCQNKPRSEYIVAEYDAYFEEVKQEIN 2047
Query: 213 ASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE 272
L L+ L KP R+ KY LLK+ R+ E + DI+K++ + +C +
Sbjct: 2048 QR----LTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCND 2103
Query: 273 VRKRKELELQILTEAIRNWEGD---DIKTLGNVTYMSQVLIQCAGSEEK-NERYLLLFPN 328
+ L+ +EG K L T+ V+ AG + + ER + LF
Sbjct: 2104 MMNLGRLQ---------GFEGTLTAQGKLLQQDTF--YVIELDAGMQSRTKERRVFLFEQ 2152
Query: 329 VLL---MLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQ 385
+++ +L G++++ + + + + D++ + A ++ ER+++ N
Sbjct: 2153 IVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL-MNRETSERVVLQAANA 2211
Query: 386 QDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTL 445
Q WV+ + N ++ + L S P+ K + PA L
Sbjct: 2212 DIQQAWVQDI----------NQVLETQRDFLNALQS-PIEYQRKERSTAVMRSQPA--RL 2258
Query: 446 PHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAA 488
P S P++++ G +PPK S P PPL+ S +
Sbjct: 2259 PQASPR--PYSSVPAGSEKPPK-----GSSYNPPLPPLKISTS 2294
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 78.2 bits (191), Expect = 2e-14
Identities = 82/358 (22%), Positives = 160/358 (44%), Gaps = 54/358 (15%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI----SYLMGNLEEICSFQQ-ML 151
++ +L+TE Y ++L L TYL + + + I + GN++EI F +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 152 VQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE-LGEFMET 210
++ LE+ +LPE VG CF+ + + +Y+TYC N P + ++ EH+ E +
Sbjct: 1345 LKELEKYEQLPED---VGHCFVTWADKFQ-MYVTYCKNKPDSNQLILEHAGTFFDEIQQR 1400
Query: 211 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQC 270
G ++ +++ L KP R+ KY LLKEL E+ + +D + M + +
Sbjct: 1401 HGLANS----ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA 1456
Query: 271 QEVRK----RKELELQ---ILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYL 323
V + L++Q IL +A + W+ + G ER+L
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------------RERHL 1498
Query: 324 LLFPNVLLMLSASPRMSG---FIYQGKLPTTGMTITKLEDSENHRNAF--EISGSMIERI 378
LF L+ SG ++Y+ KL T+ + +T+ + + + A + S +
Sbjct: 1499 FLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKT 1558
Query: 379 LVSCNNQQDLQEWVEHLQK--QTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK 434
++ +N + QEW++++++ Q ++ + +P +P TP+ + +SK
Sbjct: 1559 VLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPK--------TPAKQRNNSK 1608
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 78.2 bits (191), Expect = 2e-14
Identities = 60/213 (28%), Positives = 95/213 (44%), Gaps = 23/213 (10%)
Query: 60 VREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTY 119
+ E+ S++ SP+ T P + V+ +LETE Y K+L ++ Y
Sbjct: 1009 LHEMNPSDQSPSPQDST--GPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERY 1066
Query: 120 LRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKL-PEAQQ------------ 166
L+PLQ L+ + L GNL E+ FQ +++LE+ +L P+ ++
Sbjct: 1067 LKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLF 1126
Query: 167 RVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELG--EFMETKGASSPGILVLTTG 224
+GG FL + K LY +CA+H VL + + F++ + L +
Sbjct: 1127 SLGGSFLYYADRFK-LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESY 1185
Query: 225 LSKPFMRLDKYPTLLKEL-----ERHMEDYHTD 252
L KP R+ KYP LL+EL E YH D
Sbjct: 1186 LIKPIQRILKYPLLLRELFALTDAESEEHYHLD 1218
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 80 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 139
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 11 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 70
Query: 140 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 186
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 71 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 129
Query: 187 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 244
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 130 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 189
Query: 245 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 275
+ + + +++ A + +++ E++K
Sbjct: 190 LTDQESEEHYHLTEALKAMEKVASHINEMQK 220
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 16/211 (7%)
Query: 80 PPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMG 139
PP+ + V+Q +++TE Y K+L + YL PLQ L+ + L G
Sbjct: 1086 PPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFG 1145
Query: 140 NLEEICSFQQMLVQSLEE---------CTKLPEAQQR----VGGCFLNLMPQMKTLYLTY 186
+L E+ FQ++ +++LE+ + P ++ +GG FL K LY +
Sbjct: 1146 SLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGF 1204
Query: 187 CANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELER 244
CANH VL + + F++ + + L + L KP R+ KYP LLKEL
Sbjct: 1205 CANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVS 1264
Query: 245 HMEDYHTDRQDIQKSMAAFKNLSAQCQEVRK 275
+ + + +++ A + +++ E++K
Sbjct: 1265 LTDQESEEHYHLTEALKAMEKVASHINEMQK 1295
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 74.3 bits (181), Expect = 3e-13
Identities = 48/197 (24%), Positives = 96/197 (48%), Gaps = 19/197 (9%)
Query: 97 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 156
V++ +L+TE +Y ++L+ + + P+Q ++ + + + L GN++ + + L+ +LE
Sbjct: 788 VIEELLQTERDYIRDLEMCIERIMVPMQQAQ-VPNIDFEGLFGNMQMVIKVSKQLLAALE 846
Query: 157 ECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFMETKGAS 214
VG FL +++ Y YC NH A+ +L E E++ + ++ A
Sbjct: 847 -------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLAD 899
Query: 215 SPGI---------LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKN 265
+ + L + L KP R+ +YP LL EL + H D+ + ++ A K
Sbjct: 900 LKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKE 959
Query: 266 LSAQCQEVRKRKELELQ 282
++ E ++RK+L L+
Sbjct: 960 INVNINEYKRRKDLVLK 976
Score = 52.8 bits (125), Expect = 1e-06
Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR---EVKASEKP 69
A + FQ +EL F GD I + E GW EG+L GRTG FP +V+ + + E
Sbjct: 250 ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETM 309
Query: 70 VSPKSGTLKSPPK 82
P+ G+L P+
Sbjct: 310 ALPQEGSLARIPE 322
Score = 47.0 bits (110), Expect = 5e-05
Identities = 22/49 (44%), Positives = 28/49 (57%)
Query: 12 RAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYV 60
RA ++EL F +GDVI + V E GW+EG L GR G FP +V
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFV 199
Score = 38.5 bits (88), Expect = 0.019
Identities = 17/56 (30%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEE----GGWWEGTLNGRTGWFPSNYVREVK 64
A + F+ N +ELS S + + ++ WW +NG+ G+ PSNY+R+ +
Sbjct: 1520 AVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRKTE 1575
Score = 38.1 bits (87), Expect = 0.025
Identities = 22/54 (40%), Positives = 29/54 (53%)
Query: 10 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63
VVRA F+F + +EL GD+I V V + W G TG FPS++V V
Sbjct: 6 VVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIV 59
Score = 32.7 bits (73), Expect = 1.1
Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 17 FQQTNEDELSFSKGDVIHVTRVEEGGWWEG-TLNGRTGWFPSNYVREVKASEK 68
F D L +GD++ + + GW +G + G G+FPS+ VRE+ S +
Sbjct: 77 FTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 73.2 bits (178), Expect = 7e-13
Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 31/270 (11%)
Query: 134 ISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSA 193
+SYL + EI ++M VQ L + E +Y YC N+P++
Sbjct: 91 LSYLGRVVREIVETERMYVQDLRSIVESQEFD----------------IYTQYCNNYPNS 134
Query: 194 VNVLTE--HSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHT 251
V LTE ++ +F + L L + L KP R+ KY LL+E+ +H ++
Sbjct: 135 VAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEED 194
Query: 252 DRQDIQKSMAAFKNLSAQCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVL 309
+ ++ ++ ++ ++++R E + LQ + + NW+G D+ T G +
Sbjct: 195 GFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFR 254
Query: 310 IQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFE 369
+ +NER LF LL+ R F+Y+G +P + + L +S F
Sbjct: 255 VH----RVRNERTFFLFDKTLLI--TKKRGDHFVYKGNIPCSSL---MLIESTRDSLCFT 305
Query: 370 IS--GSMIERILVSCNNQQDLQEWVEHLQK 397
++ ++ + ++ + W H+++
Sbjct: 306 VTHYKHSKQQYSIQAKTVEEKRNWTHHIKR 335
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 71.6 bits (174), Expect = 2e-12
Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 7/132 (5%)
Query: 14 KFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPK 73
+F++Q ++DEL+ S G++I R E+GGWWEG +NGR G FP N+VRE+K K +
Sbjct: 7 EFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIK---KEMKKD 63
Query: 74 SGTLKSPPKGFDTTAINKSYYNVVLQNILET--ENEYSKELQTVLSTYLRPLQTSEKLSS 131
T K+P K S + + IL T E + V +YL +L
Sbjct: 64 PLTNKAPEKPLHEVPSGNSLLS--SETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121
Query: 132 ANISYLMGNLEE 143
+I ++G +EE
Sbjct: 122 GDIIEVVGEVEE 133
Score = 62.8 bits (151), Expect = 1e-09
Identities = 25/49 (51%), Positives = 34/49 (69%)
Query: 15 FNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63
F++ N+DEL GD+I V E GWWEG LNG+TG FPSN+++E+
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 155
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/94 (31%), Positives = 48/94 (51%), Gaps = 18/94 (19%)
Query: 3 DNSNNQLVVRAK--------FNFQQTNEDELSFSKGDVIHVTRVE--EGGWWEGTLNGRT 52
D+S ++ R K F ++ N+DEL+ +GD++ + + + GWWEG LNGR
Sbjct: 256 DSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR 315
Query: 53 GWFPSNYV--------REVKASEKPVSPKSGTLK 78
G FP N+V +E +KP P + +K
Sbjct: 316 GVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIK 349
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,190,585
Number of Sequences: 37866
Number of extensions: 1378056
Number of successful extensions: 9163
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 619
Number of HSP's that attempted gapping in prelim test: 6930
Number of HSP's gapped (non-prelim): 2571
length of query: 646
length of database: 18,247,518
effective HSP length: 109
effective length of query: 537
effective length of database: 14,120,124
effective search space: 7582506588
effective search space used: 7582506588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.