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Search of human proteins with 4504465
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504465 homeobox B2 [Homo sapiens]
(356 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504465 homeobox B2 [Homo sapiens] 735 0.0
gi|10140847 homeobox A2 [Homo sapiens] 304 9e-83
gi|24497513 homeobox A3 isoform a [Homo sapiens] 136 3e-32
gi|13562112 homeobox A3 isoform a [Homo sapiens] 136 3e-32
gi|84570137 homeobox B3 [Homo sapiens] 127 2e-29
gi|19923391 homeobox D3 [Homo sapiens] 126 3e-29
gi|4557673 pancreatic and duodenal homeobox 1 [Homo sapiens] 114 2e-25
gi|24497515 homeobox A3 isoform b [Homo sapiens] 112 4e-25
gi|23397672 homeobox D4 [Homo sapiens] 111 9e-25
gi|13273315 homeobox B4 [Homo sapiens] 111 1e-24
gi|24497538 homeobox C4 [Homo sapiens] 109 4e-24
gi|24497540 homeobox C4 [Homo sapiens] 109 4e-24
gi|24497526 homeobox B1 [Homo sapiens] 107 1e-23
gi|148613882 homeobox A4 [Homo sapiens] 102 4e-22
gi|5031761 homeobox A1 isoform a [Homo sapiens] 99 4e-21
gi|121114296 caudal type homeobox 1 [Homo sapiens] 99 8e-21
gi|23510368 homeobox D11 [Homo sapiens] 94 2e-19
gi|24497517 homeobox A5 [Homo sapiens] 94 2e-19
gi|13375632 homeobox D1 [Homo sapiens] 93 4e-19
gi|4504469 homeobox B5 [Homo sapiens] 92 7e-19
gi|15029506 homeobox D8 [Homo sapiens] 89 5e-18
gi|18959212 GS homeobox 2 [Homo sapiens] 89 5e-18
gi|33457326 GS homeobox 1 [Homo sapiens] 89 8e-18
gi|24497533 homeobox C10 [Homo sapiens] 89 8e-18
gi|11321638 homeobox C5 [Homo sapiens] 88 1e-17
gi|13489077 homeobox A6 [Homo sapiens] 87 2e-17
gi|149588930 gastrulation brain homeo box 1 [Homo sapiens] 87 2e-17
gi|194363768 homeobox D9 [Homo sapiens] 86 4e-17
gi|24497556 homeobox A7 [Homo sapiens] 86 5e-17
gi|23503237 homeobox B6 [Homo sapiens] 86 7e-17
>gi|4504465 homeobox B2 [Homo sapiens]
Length = 356
Score = 735 bits (1897), Expect = 0.0
Identities = 356/356 (100%), Positives = 356/356 (100%)
Query: 1 MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGA 60
MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGA
Sbjct: 1 MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGA 60
Query: 61 STLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASA 120
STLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASA
Sbjct: 61 STLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASA 120
Query: 121 VPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALL 180
VPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALL
Sbjct: 121 VPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALL 180
Query: 181 DLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRA 240
DLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRA
Sbjct: 181 DLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRA 240
Query: 241 AWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQD 300
AWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQD
Sbjct: 241 AWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQD 300
Query: 301 SPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP 356
SPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP
Sbjct: 301 SPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP 356
>gi|10140847 homeobox A2 [Homo sapiens]
Length = 376
Score = 304 bits (778), Expect = 9e-83
Identities = 191/383 (49%), Positives = 222/383 (57%), Gaps = 40/383 (10%)
Query: 1 MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPP---PPPFEQTFPSLQ 57
MN+EFEREIGFINSQPSLAECLTSFP V +TFQ+SSIK STL PPPFEQT PSL
Sbjct: 1 MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLN 60
Query: 58 PGASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPA 117
PG+ R + R + PA P P A P PE+PWMKEKK+AKK + + + A
Sbjct: 61 PGSHP--RHGAGGRPKPSPAGSRGSPVPAGALQP-PEYPWMKEKKAAKKTALLPAAAAAA 117
Query: 118 ASAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIA 177
+A S + L + + GGG+RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIA
Sbjct: 118 TAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIA 177
Query: 178 ALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAE--------EPA 229
ALLDLTERQVKVWFQNRRMKHKRQTQ +E + E C +LED E E A
Sbjct: 178 ALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCK-SLEDSEKVEEDEEEKTLFEQA 236
Query: 230 ASPGGPSASRAAW--EACCHPPEVVPGALSADPRPLAV-----------RLEGAGASSPG 276
S G R + + + P + D + V + + P
Sbjct: 237 LSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPN 296
Query: 277 CALR-----GAGGLEPGPLPEDVFSGRQDSPFLPDLNFFAADSCLQLSGGLSPSLQGSLD 331
C GAG P +V P L D + F+ DSCLQLS +SPSL GSLD
Sbjct: 297 CLSTMGQNCGAGLNNDSPEALEV-------PSLQDFSVFSTDSCLQLSDAVSPSLPGSLD 349
Query: 332 SPVPFSEEELDFFTSTLCAIDLQ 354
SPV S + LDFFT TL IDLQ
Sbjct: 350 SPVDISADSLDFFTDTLTTIDLQ 372
>gi|24497513 homeobox A3 isoform a [Homo sapiens]
Length = 443
Score = 136 bits (342), Expect = 3e-32
Identities = 102/281 (36%), Positives = 130/281 (46%), Gaps = 60/281 (21%)
Query: 33 QTSSIKESTLIPPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGPALPPPP----PPPLPA 88
Q S+ E L PPPP + P+ QP Q P PA PPPP PP +
Sbjct: 81 QPPSLGEPPLHPPPP--QAAPPAPQPPQPAPQPPAPT------PAAPPPPSSASPPQNAS 132
Query: 89 APPAPE-----------------FPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPAD 131
P P FPWMKE + K S++S S +G SP
Sbjct: 133 NNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSS-----SGESCAGDKSPP- 186
Query: 132 GLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWF 191
G ++R RTAYT+ QL+ELEKEFHFN+YLCRPRRVE+A LL+LTERQ+K+WF
Sbjct: 187 -------GQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWF 239
Query: 192 QNRRMKHKRQTQHR--------EPPDGEPACPGA------LEDICDPAEEPAASPGGPSA 237
QNRRMK+K+ + + + P P PGA + + + SP P
Sbjct: 240 QNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSP--PPF 297
Query: 238 SRAAWEACCHPPEVVPGAL--SADPRPLAVRLEGAGASSPG 276
S+ PP P +L A P P R AGA + G
Sbjct: 298 SKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGG 338
>gi|13562112 homeobox A3 isoform a [Homo sapiens]
Length = 443
Score = 136 bits (342), Expect = 3e-32
Identities = 102/281 (36%), Positives = 130/281 (46%), Gaps = 60/281 (21%)
Query: 33 QTSSIKESTLIPPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGPALPPPP----PPPLPA 88
Q S+ E L PPPP + P+ QP Q P PA PPPP PP +
Sbjct: 81 QPPSLGEPPLHPPPP--QAAPPAPQPPQPAPQPPAPT------PAAPPPPSSASPPQNAS 132
Query: 89 APPAPE-----------------FPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPAD 131
P P FPWMKE + K S++S S +G SP
Sbjct: 133 NNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSS-----SGESCAGDKSPP- 186
Query: 132 GLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWF 191
G ++R RTAYT+ QL+ELEKEFHFN+YLCRPRRVE+A LL+LTERQ+K+WF
Sbjct: 187 -------GQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWF 239
Query: 192 QNRRMKHKRQTQHR--------EPPDGEPACPGA------LEDICDPAEEPAASPGGPSA 237
QNRRMK+K+ + + + P P PGA + + + SP P
Sbjct: 240 QNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSP--PPF 297
Query: 238 SRAAWEACCHPPEVVPGAL--SADPRPLAVRLEGAGASSPG 276
S+ PP P +L A P P R AGA + G
Sbjct: 298 SKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGG 338
>gi|84570137 homeobox B3 [Homo sapiens]
Length = 431
Score = 127 bits (319), Expect = 2e-29
Identities = 92/264 (34%), Positives = 123/264 (46%), Gaps = 37/264 (14%)
Query: 44 PPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKS 103
P PP PS P ++T ++ GP P P + FPWMKE +
Sbjct: 87 PGSPP-----PSAAPTSATSNSSNGGGPSKSGP---PKCGPGTNSTLTKQIFPWMKESRQ 138
Query: 104 AKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGGG----------ARRLRTAYTNT 153
K ++ + G G + G G GGGG ++R RTAYT+
Sbjct: 139 TSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSA 198
Query: 154 QLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPA 213
QL+ELEKEFHFN+YLCRPRRVE+A LL+L+ERQ+K+WFQNRRMK+K+ + + G +
Sbjct: 199 QLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAK----GLAS 254
Query: 214 CPGALEDICDPAEEPAASPGGPSASRAAWEACCHPPEVVPGALSADPRPLAVRLEGAGA- 272
G PA SP P S A + H + P S P + A A
Sbjct: 255 SSG--------GPSPAGSPPQPMQSTAGFMNALH--SMTPSYESPSPPAFGKAHQNAYAL 304
Query: 273 -SSPGCALRGAGGLE---PGPLPE 292
S+ L+G G + P P PE
Sbjct: 305 PSNYQPPLKGCGAPQKYPPTPAPE 328
>gi|19923391 homeobox D3 [Homo sapiens]
Length = 432
Score = 126 bits (317), Expect = 3e-29
Identities = 85/235 (36%), Positives = 115/235 (48%), Gaps = 48/235 (20%)
Query: 72 AEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVP--------- 122
+E P PPPPPP LP + P + KK P+ S++S + + P
Sbjct: 112 SEQQPPQPPPPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNS 171
Query: 123 -----ASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIA 177
+ G + P G ++R+RTAYT+ QL+ELEKEFHFN+YLCRPRRVE+A
Sbjct: 172 KQKNSCATAGESCEDKSPP---GPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMA 228
Query: 178 ALLDLTERQVKVWFQNRRMKHKR-------------QTQHREPPDGE-----------PA 213
LL+LTERQ+K+WFQNRRMK+K+ Q+ R PP G P
Sbjct: 229 NLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPP 288
Query: 214 CPGALEDICDPAEEPAASPGGPS----ASRAAWEACCHPPEVVPGALSADPRPLA 264
PG D P PA + P+ A+ A + C P + A +P P+A
Sbjct: 289 VPGLAYDAPSP---PAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMA 340
>gi|4557673 pancreatic and duodenal homeobox 1 [Homo sapiens]
Length = 283
Score = 114 bits (284), Expect = 2e-25
Identities = 96/282 (34%), Positives = 117/282 (41%), Gaps = 67/282 (23%)
Query: 44 PPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGPA-------------LPPPPPPPLP--A 88
PPP PF +L+ G+ P D PA LP PP P P A
Sbjct: 45 PPPHPFPGALGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGA 104
Query: 89 APPAPE--------FPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGG 140
P E FPWMK K+ Q A A +A P
Sbjct: 105 EPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGG---AYAAEPEEN--------------- 146
Query: 141 GGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKR 200
+R RTAYT QLLELEKEF FNKY+ RPRRVE+A +L+LTER +K+WFQNRRMK K+
Sbjct: 147 ---KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKK 203
Query: 201 QTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRAAWEACCHPPEVVPGALSADP 260
+ + G A G + +P ++ A + G E PP PG
Sbjct: 204 EEDKKR--GGGTAVGGG--GVAEPEQDCAVTSGE--------ELLALPPPPPPGGAVPPA 251
Query: 261 RPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQDSP 302
P+A R EG R GL P P V R P
Sbjct: 252 APVAAR-EG----------RLPPGLSASPQPSSVAPRRPQEP 282
>gi|24497515 homeobox A3 isoform b [Homo sapiens]
Length = 285
Score = 112 bits (281), Expect = 4e-25
Identities = 76/195 (38%), Positives = 100/195 (51%), Gaps = 31/195 (15%)
Query: 98 MKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLE 157
MKE + K S++S S +G SP G ++R RTAYT+ QL+E
Sbjct: 1 MKESRQNTKQKTSSSS-----SGESCAGDKSPP--------GQASSKRARTAYTSAQLVE 47
Query: 158 LEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHR--------EPPD 209
LEKEFHFN+YLCRPRRVE+A LL+LTERQ+K+WFQNRRMK+K+ + + + P
Sbjct: 48 LEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPS 107
Query: 210 GEPACPGA------LEDICDPAEEPAASPGGPSASRAAWEACCHPPEVVPGAL--SADPR 261
P PGA + + + SP P S+ PP P +L A P
Sbjct: 108 RSPVPPGAGGYLNSMHSLVNSVPYEPQSP--PPFSKPPQGTYGLPPASYPASLPSCAPPP 165
Query: 262 PLAVRLEGAGASSPG 276
P R AGA + G
Sbjct: 166 PPQKRYTAAGAGAGG 180
>gi|23397672 homeobox D4 [Homo sapiens]
Length = 255
Score = 111 bits (278), Expect = 9e-25
Identities = 77/207 (37%), Positives = 100/207 (48%), Gaps = 20/207 (9%)
Query: 33 QTSSIKESTLIPPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGP----ALPPPPPPPLPA 88
Q + + L P P EQ F PG + R + GP A P P P PA
Sbjct: 42 QGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPA 101
Query: 89 APPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSP------ADGLGLPEAGGGG 142
PPAP A+ SQS P+ +A+ V P + + P GG
Sbjct: 102 PPPAP-------LPGARAYSQSDPKQPPSGTALKQPAVVYPWMKKVHVNSVN-PNYTGGE 153
Query: 143 ARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQT 202
+R RTAYT Q+LELEKEFHFN+YL R RR+EIA L L+ERQ+K+WFQNRRMK K+
Sbjct: 154 PKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKK-- 211
Query: 203 QHREPPDGEPACPGALEDICDPAEEPA 229
H+ P + + C + P+
Sbjct: 212 DHKLPNTKGRSSSSSSSSSCSSSVAPS 238
>gi|13273315 homeobox B4 [Homo sapiens]
Length = 251
Score = 111 bits (277), Expect = 1e-24
Identities = 81/198 (40%), Positives = 101/198 (51%), Gaps = 26/198 (13%)
Query: 60 ASTLQRPRSQKRAEDGPALPPPPPPP--------LPAAPPA----PEFPWMKEKKSAKKP 107
A T+QR + + P PPPPPPP PA PPA PE E S+ P
Sbjct: 59 ACTVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPP 118
Query: 108 ----SQSATSPSPAASAVPASGVGSPADGLGL----PEAGGGGARRLRTAYTNTQLLELE 159
+Q+ PSP+ SA V + + P GG +R RTAYT Q+LELE
Sbjct: 119 PPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELE 178
Query: 160 KEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALE 219
KEFH+N+YL R RRVEIA L L+ERQ+K+WFQNRRMK K+ + P+ + GA
Sbjct: 179 KEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKD---HKLPNTKIRSGGAAG 235
Query: 220 DICDPAEEPAASPGGPSA 237
P P GGP A
Sbjct: 236 SAGGP---PGRPNGGPRA 250
>gi|24497538 homeobox C4 [Homo sapiens]
Length = 264
Score = 109 bits (272), Expect = 4e-24
Identities = 80/212 (37%), Positives = 103/212 (48%), Gaps = 42/212 (19%)
Query: 42 LIPPPPPFEQTFPSLQPGASTLQRP-----------------RSQKRAEDGP---ALPPP 81
L PPPPP ++P Q ++LQ P +SQ E P A P
Sbjct: 52 LYPPPPP-RPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASP 110
Query: 82 PPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGG 141
P P + PAP+ P ++K+P P + S V P GG
Sbjct: 111 SPAPPACSQPAPDHP---SSAASKQPIVY-----PWMKKIHVSTVN--------PNYNGG 154
Query: 142 GARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQ 201
+R RTAYT Q+LELEKEFH+N+YL R RR+EIA L L+ERQ+K+WFQNRRMK K+
Sbjct: 155 EPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKK- 213
Query: 202 TQHREPPDGEPACPGALEDICDPAEEPAASPG 233
HR P + P A P+ AA+PG
Sbjct: 214 -DHRLPNTKVRSAPPA---GAAPSTLSAATPG 241
>gi|24497540 homeobox C4 [Homo sapiens]
Length = 264
Score = 109 bits (272), Expect = 4e-24
Identities = 80/212 (37%), Positives = 103/212 (48%), Gaps = 42/212 (19%)
Query: 42 LIPPPPPFEQTFPSLQPGASTLQRP-----------------RSQKRAEDGP---ALPPP 81
L PPPPP ++P Q ++LQ P +SQ E P A P
Sbjct: 52 LYPPPPP-RPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASP 110
Query: 82 PPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGG 141
P P + PAP+ P ++K+P P + S V P GG
Sbjct: 111 SPAPPACSQPAPDHP---SSAASKQPIVY-----PWMKKIHVSTVN--------PNYNGG 154
Query: 142 GARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQ 201
+R RTAYT Q+LELEKEFH+N+YL R RR+EIA L L+ERQ+K+WFQNRRMK K+
Sbjct: 155 EPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKK- 213
Query: 202 TQHREPPDGEPACPGALEDICDPAEEPAASPG 233
HR P + P A P+ AA+PG
Sbjct: 214 -DHRLPNTKVRSAPPA---GAAPSTLSAATPG 241
>gi|24497526 homeobox B1 [Homo sapiens]
Length = 301
Score = 107 bits (268), Expect = 1e-23
Identities = 69/155 (44%), Positives = 80/155 (51%), Gaps = 29/155 (18%)
Query: 82 PPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGG 141
P P P P A F WMK K++ P + V G+GSP+
Sbjct: 167 PCPSEPNTPTARTFDWMKVKRNP-----------PKTAKVSEPGLGSPSG---------- 205
Query: 142 GARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKH-KR 200
LRT +T QL ELEKEFHFNKYL R RRVEIAA L+L E QVK+WFQNRRMK KR
Sbjct: 206 ----LRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNETQVKIWFQNRRMKQKKR 261
Query: 201 QTQHREPPDGEPACP-GALEDICDPA--EEPAASP 232
+ + P P CP A D D + P ASP
Sbjct: 262 EREEGRVPPAPPGCPKEAAGDASDQSTCTSPEASP 296
>gi|148613882 homeobox A4 [Homo sapiens]
Length = 320
Score = 102 bits (255), Expect = 4e-22
Identities = 71/179 (39%), Positives = 86/179 (48%), Gaps = 18/179 (10%)
Query: 54 PSLQPGASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATS 113
P LQP A P + +R E PA P +PA AP P + KS
Sbjct: 142 PPLQPRAVP---PAAPRRCEAAPATPG-----VPAGGSAPACPLLLADKSPLGLKGKEPV 193
Query: 114 PSPAASAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRR 173
P + S V P GG +R RTAYT Q+LELEKEFHFN+YL R RR
Sbjct: 194 VYPWMKKIHVSAVN--------PSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRR 245
Query: 174 VEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASP 232
+EIA L L+ERQVK+WFQNRRMK K+ H+ P + A P + SP
Sbjct: 246 IEIAHTLCLSERQVKIWFQNRRMKWKK--DHKLPNTKMRSSNSASASAGPPGKAQTQSP 302
>gi|5031761 homeobox A1 isoform a [Homo sapiens]
Length = 335
Score = 99.4 bits (246), Expect = 4e-21
Identities = 63/153 (41%), Positives = 78/153 (50%), Gaps = 24/153 (15%)
Query: 84 PPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGGGA 143
P + PA F WMK K++ P +G LG P A
Sbjct: 194 PASETSSPAQTFDWMKVKRNP-----------------PKTGKVGEYGYLGQPNA----- 231
Query: 144 RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQ 203
+RT +T QL ELEKEFHFNKYL R RRVEIAA L L E QVK+WFQNRRMK K++ +
Sbjct: 232 --VRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREK 289
Query: 204 HREPPDGEPACPGALEDICDPAEEPAASPGGPS 236
P PG E + +E+ ++SP PS
Sbjct: 290 EGLLPISPATPPGNDEKAEESSEKSSSSPCVPS 322
>gi|121114296 caudal type homeobox 1 [Homo sapiens]
Length = 265
Score = 98.6 bits (244), Expect = 8e-21
Identities = 77/221 (34%), Positives = 97/221 (43%), Gaps = 71/221 (32%)
Query: 75 GPALPPPPPP------------PLPAAP-------PAPEFPWMKE-----KKSAKKPSQS 110
GP PPP PP P PA P PAP+ W A P+
Sbjct: 31 GPPAPPPAPPQYPDFSSYSHVEPAPAPPTAWGAPFPAPKDDWAAAYGPGPAAPAASPASL 90
Query: 111 ATSPSPAASAVPASG------VGSPADGLGLPEA-------------------GGGGARR 145
A P P S VPA + P G G P + GGGG+ +
Sbjct: 91 AFGPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGK 150
Query: 146 LRT------AYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMK-- 197
RT YT+ Q LELEKEFH+++Y+ R+ E+AA L LTERQVK+WFQNRR K
Sbjct: 151 TRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKER 210
Query: 198 --HKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPS 236
+K++ Q ++PP P DI A+P GPS
Sbjct: 211 KVNKKKQQQQQPPQ-----PPMAHDI-------TATPAGPS 239
>gi|23510368 homeobox D11 [Homo sapiens]
Length = 338
Score = 94.0 bits (232), Expect = 2e-19
Identities = 56/149 (37%), Positives = 74/149 (49%), Gaps = 19/149 (12%)
Query: 72 AEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPAS-----GV 126
A GP P PPP PPAP P K + SP A P S
Sbjct: 184 AAPGPPFAGPQPPP----PPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAE 239
Query: 127 GSPADGLGLPEAGGGG----------ARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEI 176
GS DG G P G +R+ R YT Q+ ELE+EF FN Y+ + +R+++
Sbjct: 240 GSGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQL 299
Query: 177 AALLDLTERQVKVWFQNRRMKHKRQTQHR 205
+ +L+LT+RQVK+WFQNRRMK K+ + R
Sbjct: 300 SRMLNLTDRQVKIWFQNRRMKEKKLNRDR 328
>gi|24497517 homeobox A5 [Homo sapiens]
Length = 270
Score = 93.6 bits (231), Expect = 2e-19
Identities = 48/105 (45%), Positives = 65/105 (61%)
Query: 99 KEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLEL 158
++ ++ + + + + PSPA A P + GG +R RTAYT Q LEL
Sbjct: 151 EDAPASSEQASAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLEL 210
Query: 159 EKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQ 203
EKEFHFN+YL R RR+EIA L L+ERQ+K+WFQNRRMK K+ +
Sbjct: 211 EKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNK 255
>gi|13375632 homeobox D1 [Homo sapiens]
Length = 328
Score = 92.8 bits (229), Expect = 4e-19
Identities = 64/181 (35%), Positives = 82/181 (45%), Gaps = 25/181 (13%)
Query: 60 ASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPA-PEFPWMKEKKSAKKPSQSATSPSPAA 118
AS P + + A P P P P A F WMK K++A K + A
Sbjct: 169 ASADGHPGAFQTASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEY----- 223
Query: 119 SAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAA 178
G SP+ + RT ++ QL ELEKEFHFNKYL R RR+EIA
Sbjct: 224 ------GAASPSSAI-------------RTNFSTKQLTELEKEFHFNKYLTRARRIEIAN 264
Query: 179 LLDLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSAS 238
L L + QVK+WFQNRRMK K++ + P P L + +PG PS S
Sbjct: 265 CLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVAPLQLPLSGTTPTKFIKNPGSPSQS 324
Query: 239 R 239
+
Sbjct: 325 Q 325
>gi|4504469 homeobox B5 [Homo sapiens]
Length = 269
Score = 92.0 bits (227), Expect = 7e-19
Identities = 59/150 (39%), Positives = 72/150 (48%), Gaps = 37/150 (24%)
Query: 60 ASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPE------FPWMKEKKSAKKPSQSATS 113
AS P P+L P P+ + APE FPWM++ S T
Sbjct: 136 ASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWMRKLHI----SHDMTG 191
Query: 114 PSPAASAVPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRR 173
P DG +R RTAYT Q LELEKEFHFN+YL R RR
Sbjct: 192 P----------------DG-----------KRARTAYTRYQTLELEKEFHFNRYLTRRRR 224
Query: 174 VEIAALLDLTERQVKVWFQNRRMKHKRQTQ 203
+EIA L L+ERQ+K+WFQNRRMK K+ +
Sbjct: 225 IEIAHALCLSERQIKIWFQNRRMKWKKDNK 254
>gi|15029506 homeobox D8 [Homo sapiens]
Length = 290
Score = 89.4 bits (220), Expect = 5e-18
Identities = 67/200 (33%), Positives = 85/200 (42%), Gaps = 33/200 (16%)
Query: 44 PPPPPFEQTFPSLQPGASTLQRPRSQKRAEDGPALPPPPPPPLPAAPPAP---------- 93
P PPP + P A A PPPPP P P PP P
Sbjct: 74 PSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPPPPCGGIACHGEP 133
Query: 94 -------------EFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGL--PEA 138
F +E + + P ++S + + SP+ P+A
Sbjct: 134 AKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQA 193
Query: 139 GGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKH 198
G RR R Y+ Q LELEKEF FN YL R RR+E++ L LTERQVK+WFQNRRMK
Sbjct: 194 APG-RRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKW 252
Query: 199 KRQ-------TQHREPPDGE 211
K++ +E DGE
Sbjct: 253 KKENNKDKFPVSRQEVKDGE 272
>gi|18959212 GS homeobox 2 [Homo sapiens]
Length = 304
Score = 89.4 bits (220), Expect = 5e-18
Identities = 50/119 (42%), Positives = 72/119 (60%), Gaps = 22/119 (18%)
Query: 105 KKPSQSATSPSPAASAVPASGVGSPADGLGLPEA----------------GGGGA----- 143
++P +A + + AA+A A+ +G P + A GG A
Sbjct: 142 QQPGSAAAAAAAAAAAAAAAALGHPQHHAPVCTATTYNVADPRRFHCLTMGGSDASQVPN 201
Query: 144 -RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQ 201
+R+RTA+T+TQLLELE+EF N YL R RR+EIA L+L+E+QVK+WFQNRR+KHK++
Sbjct: 202 GKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKE 260
>gi|33457326 GS homeobox 1 [Homo sapiens]
Length = 264
Score = 88.6 bits (218), Expect = 8e-18
Identities = 64/186 (34%), Positives = 91/186 (48%), Gaps = 29/186 (15%)
Query: 80 PPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPA---DGLGLP 136
PP PP LP + FP + + ++ SP + PA+ + A LP
Sbjct: 70 PPGPPALPLLKAS--FPPFGSQYCHAPLGRQHSAVSPGVAHGPAAAAAAAALYQTSYPLP 127
Query: 137 EAGG-------------GGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLT 183
+ ++R+RTA+T+TQLLELE+EF N YL R RR+EIA L+L+
Sbjct: 128 DPRQFHCISVDSSSNQLPSSKRMRTAFTSTQLLELEREFASNMYLSRLRRIEIATYLNLS 187
Query: 184 ERQVKVWFQNRRMKHKRQ---TQHREPPDGEPACPGALEDICDPA--------EEPAASP 232
E+QVK+WFQNRR+KHK++ + HR G G+ C A E+ P
Sbjct: 188 EKQVKIWFQNRRVKHKKEGKGSNHRGGGGGGAGGGGSAPQGCKCASLSSAKCSEDDDELP 247
Query: 233 GGPSAS 238
PS+S
Sbjct: 248 MSPSSS 253
>gi|24497533 homeobox C10 [Homo sapiens]
Length = 342
Score = 88.6 bits (218), Expect = 8e-18
Identities = 67/206 (32%), Positives = 94/206 (45%), Gaps = 23/206 (11%)
Query: 14 SQPSLAECLTSFPAVLETFQTSSIKESTLIPPP---------PPFEQTFPSLQPGASTLQ 64
S P CL + ++ +S S L P PFEQ SL P A L+
Sbjct: 130 SHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQR-ASLNPRAEHLE 188
Query: 65 RPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKK--PSQSATSPSPAASAVP 122
P+ G + P P + P+P ++ + K PS+S + AA + P
Sbjct: 189 SPQL------GGKVSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEKERAKAADSSP 242
Query: 123 ASGVGSPADGLGLPEAGGG-----GARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIA 177
+ + + G R+ R YT Q LELEKEF FN YL R RR+EI+
Sbjct: 243 DTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEIS 302
Query: 178 ALLDLTERQVKVWFQNRRMKHKRQTQ 203
++LT+RQVK+WFQNRRMK K+ +
Sbjct: 303 KTINLTDRQVKIWFQNRRMKLKKMNR 328
>gi|11321638 homeobox C5 [Homo sapiens]
Length = 222
Score = 87.8 bits (216), Expect = 1e-17
Identities = 67/179 (37%), Positives = 83/179 (46%), Gaps = 24/179 (13%)
Query: 40 STLIPPPPPFEQTFPSLQPGASTLQRPRSQK-RAEDGPALPPPPPPPLPAAPPAPEFPWM 98
S PPP P G PR+ R A P P A AP P M
Sbjct: 46 SITFPPPAPSNSLH-----GVDMAANPRAHPDRPACSAAAAPGHAPGRDEA--APLNPGM 98
Query: 99 KEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGG--------------GAR 144
+K+A+ P+ + S + G PA GL P A +
Sbjct: 99 YSQKAAR-PALEERAKSSGEIKEEQAQTGQPA-GLSQPPAPPQIYPWMTKLHMSHETDGK 156
Query: 145 RLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQ 203
R RT+YT Q LELEKEFHFN+YL R RR+EIA L L ERQ+K+WFQNRRMK K+ ++
Sbjct: 157 RSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSK 215
>gi|13489077 homeobox A6 [Homo sapiens]
Length = 233
Score = 87.4 bits (215), Expect = 2e-17
Identities = 44/74 (59%), Positives = 52/74 (70%), Gaps = 2/74 (2%)
Query: 140 GGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHK 199
G RR R YT Q LELEKEFHFN+YL R RR+EIA L LTERQ+K+WFQNRRMK K
Sbjct: 152 GSHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWK 211
Query: 200 RQTQ--HREPPDGE 211
++ + + P GE
Sbjct: 212 KENKLINSTQPSGE 225
>gi|149588930 gastrulation brain homeo box 1 [Homo sapiens]
Length = 363
Score = 87.4 bits (215), Expect = 2e-17
Identities = 65/175 (37%), Positives = 79/175 (45%), Gaps = 7/175 (4%)
Query: 29 LETFQTSSIKESTLIPPPPP---FEQTFPSLQPGASTLQRPRSQKRAEDGPALPPPPPPP 85
LE + +E PPPPP F +TFPSL + A G P
Sbjct: 148 LEADELLPAREKVAEPPPPPPPHFSETFPSLPAEGKVYSSDEEKLEASAGD--PAGSEQE 205
Query: 86 LPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGSPADGLGLPEAGGGGARR 145
+ E + SA P + P P +G A A GG +RR
Sbjct: 206 EEGSGGDSEDDGFLD-SSAGGPG-ALLGPKPKLKGSLGTGAEEGAPVTAGVTAPGGKSRR 263
Query: 146 LRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKR 200
RTA+T+ QLLELEKEFH KYL R +IA L L+E QVK+WFQNRR K KR
Sbjct: 264 RRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKR 318
>gi|194363768 homeobox D9 [Homo sapiens]
Length = 352
Score = 86.3 bits (212), Expect = 4e-17
Identities = 50/118 (42%), Positives = 65/118 (55%), Gaps = 18/118 (15%)
Query: 91 PAPEFPWMKEKKSAKKPSQSATSPS-PAASAVPASGVGSPADGLGLPEAGGGGARRLRTA 149
P P +E+K +P Q P+ PAA+ + A R+ R
Sbjct: 249 PIPGCSLKEEEKQHSQPQQQQLDPNNPAANWIHARST-----------------RKKRCP 291
Query: 150 YTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREP 207
YT Q LELEKEF FN YL R RR E+A +L+LTERQVK+WFQNRRMK K+ ++ + P
Sbjct: 292 YTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRRMKMKKMSKEKCP 349
>gi|24497556 homeobox A7 [Homo sapiens]
Length = 230
Score = 85.9 bits (211), Expect = 5e-17
Identities = 45/81 (55%), Positives = 55/81 (67%), Gaps = 1/81 (1%)
Query: 138 AGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMK 197
+ G +R R YT Q LELEKEFHFN+YL R RR+EIA L LTERQ+K+WFQNRRMK
Sbjct: 125 SSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMK 184
Query: 198 HKRQTQHREPPDGEPACPGAL 218
K++ + E P A GA+
Sbjct: 185 WKKEHKD-EGPTAAAAPEGAV 204
>gi|23503237 homeobox B6 [Homo sapiens]
Length = 224
Score = 85.5 bits (210), Expect = 7e-17
Identities = 40/64 (62%), Positives = 49/64 (76%)
Query: 140 GGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHK 199
G RR R YT Q LELEKEFH+N+YL R RR+EIA L LTERQ+K+WFQNRRMK K
Sbjct: 143 GPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWK 202
Query: 200 RQTQ 203
++++
Sbjct: 203 KESK 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.134 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,663,919
Number of Sequences: 37866
Number of extensions: 1489290
Number of successful extensions: 28873
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 987
Number of HSP's successfully gapped in prelim test: 1290
Number of HSP's that attempted gapping in prelim test: 10959
Number of HSP's gapped (non-prelim): 10422
length of query: 356
length of database: 18,247,518
effective HSP length: 103
effective length of query: 253
effective length of database: 14,347,320
effective search space: 3629871960
effective search space used: 3629871960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.