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Search of human proteins with 4503145
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
(396 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 806 0.0
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 532 e-151
gi|119372298 pepsinogen 3, group I [Homo sapiens] 406 e-113
gi|119372302 pepsinogen 4, group I [Homo sapiens] 406 e-113
gi|23943854 pepsinogen 5, group I [Homo sapiens] 406 e-113
gi|4503143 cathepsin D preproprotein [Homo sapiens] 363 e-100
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 353 2e-97
gi|4758754 napsin A preproprotein [Homo sapiens] 334 9e-92
gi|4506475 renin preproprotein [Homo sapiens] 287 1e-77
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 104 2e-22
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 100 2e-21
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 99 9e-21
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 96 6e-20
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 94 3e-19
gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo s... 87 3e-17
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 75 1e-13
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 67 3e-11
gi|138175817 zinc finger protein 236 [Homo sapiens] 33 0.45
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 30 3.8
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 30 5.0
gi|82775371 coiled-coil domain containing 93 [Homo sapiens] 30 5.0
gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens] 29 6.5
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 29 6.5
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 29 6.5
gi|26667219 eyes absent 1 isoform c [Homo sapiens] 29 8.5
gi|59710085 hypothetical protein LOC146562 [Homo sapiens] 29 8.5
>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
Length = 396
Score = 806 bits (2082), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC 60
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
Sbjct: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC 60
Query: 61 SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF 120
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
Sbjct: 61 SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF 120
Query: 121 QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE 180
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
Sbjct: 121 QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE 180
Query: 181 FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH 240
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
Sbjct: 181 FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH 240
Query: 241 FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA 300
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
Sbjct: 241 FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA 300
Query: 301 IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI 360
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
Sbjct: 301 IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI 360
Query: 361 HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP 396
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
Sbjct: 361 HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP 396
>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
Length = 363
Score = 532 bits (1371), Expect = e-151
Identities = 262/263 (99%), Positives = 263/263 (100%)
Query: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC 60
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
Sbjct: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC 60
Query: 61 SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF 120
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
Sbjct: 61 SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF 120
Query: 121 QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE 180
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
Sbjct: 121 QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE 180
Query: 181 FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH 240
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
Sbjct: 181 FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH 240
Query: 241 FSGSLNWVPVTKQAYWQIALDNI 263
FSGSLNWVPVTKQAYWQIALDN+
Sbjct: 241 FSGSLNWVPVTKQAYWQIALDNM 263
>gi|119372298 pepsinogen 3, group I [Homo sapiens]
Length = 388
Score = 406 bits (1044), Expect = e-113
Identities = 210/396 (53%), Positives = 276/396 (69%), Gaps = 13/396 (3%)
Query: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQ--FTE 58
MK LLLL LV L ++ +++VPL R SL++ L R L +F K HNL+ + F +
Sbjct: 1 MKWLLLLGLVAL----SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQ 56
Query: 59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118
+ ++PL NYLDMEYFGTI IG+P Q+FTV+FDTGSSNLWVPSVYC+S AC H+
Sbjct: 57 WKAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHN 116
Query: 119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVD 178
RF P SSTY ++ SI YGTGS++GI+G D V V G++ Q FG S TEPG
Sbjct: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
Query: 179 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDH 238
A FDGILGL YPS++ G TPVFDN+ Q LV +FSVY+S++ + +GS +IFGG D
Sbjct: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQ--SGSVVIFGGIDS 234
Query: 239 SHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQ 298
S+++GSLNWVPVT + YWQI +D+I + G + C+EGCQAIVDTGTSL+TGP+ I +Q
Sbjct: 235 SYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQ 294
Query: 299 NAIGAAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQG 357
+ IGA+ DG+ V C+ ++ +PD+ FTINGV Y + P+AY L C SGFQG
Sbjct: 295 SDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYIL----QSEGSCISGFQG 350
Query: 358 LDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAP 393
+++ +G LWILGDVFIRQ+++VFDR NN+VGLAP
Sbjct: 351 MNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAP 386
>gi|119372302 pepsinogen 4, group I [Homo sapiens]
Length = 388
Score = 406 bits (1043), Expect = e-113
Identities = 210/396 (53%), Positives = 276/396 (69%), Gaps = 13/396 (3%)
Query: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQ--FTE 58
MK LLLL LV L ++ +++VPL R SL++ L R L +F K HNL+ + F +
Sbjct: 1 MKWLLLLGLVAL----SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQ 56
Query: 59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118
+ ++PL NYLDMEYFGTI IG+P Q+FTV+FDTGSSNLWVPSVYC+S AC H+
Sbjct: 57 WEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHN 116
Query: 119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVD 178
RF P SSTY ++ SI YGTGS++GI+G D V V G++ Q FG S TEPG
Sbjct: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
Query: 179 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDH 238
A FDGILGL YPS++ G TPVFDN+ Q LV +FSVY+S++ + +GS +IFGG D
Sbjct: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQ--SGSVVIFGGIDS 234
Query: 239 SHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQ 298
S+++GSLNWVPVT + YWQI +D+I + G + C+EGCQAIVDTGTSL+TGP+ I +Q
Sbjct: 235 SYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQ 294
Query: 299 NAIGAAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQG 357
+ IGA+ DG+ V C+ ++ +PD+ FTINGV Y + P+AY L C SGFQG
Sbjct: 295 SDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYIL----QSEGSCISGFQG 350
Query: 358 LDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAP 393
+++ +G LWILGDVFIRQ+++VFDR NN+VGLAP
Sbjct: 351 MNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAP 386
>gi|23943854 pepsinogen 5, group I [Homo sapiens]
Length = 388
Score = 406 bits (1043), Expect = e-113
Identities = 210/396 (53%), Positives = 276/396 (69%), Gaps = 13/396 (3%)
Query: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQ--FTE 58
MK LLLL LV L ++ +++VPL R SL++ L R L +F K HNL+ + F +
Sbjct: 1 MKWLLLLGLVAL----SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQ 56
Query: 59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118
+ ++PL NYLDMEYFGTI IG+P Q+FTV+FDTGSSNLWVPSVYC+S AC H+
Sbjct: 57 WEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHN 116
Query: 119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVD 178
RF P SSTY ++ SI YGTGS++GI+G D V V G++ Q FG S TEPG
Sbjct: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
Query: 179 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDH 238
A FDGILGL YPS++ G TPVFDN+ Q LV +FSVY+S++ + +GS +IFGG D
Sbjct: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDK--SGSVVIFGGIDS 234
Query: 239 SHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQ 298
S+++GSLNWVPVT + YWQI +D+I + G + C+EGCQAIVDTGTSL+TGP+ I +Q
Sbjct: 235 SYYTGSLNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQ 294
Query: 299 NAIGAAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQG 357
+ IGA+ DG+ V C+ ++ +PD+ FTINGV Y + P+AY L C SGFQG
Sbjct: 295 SDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYIL----QSEGSCISGFQG 350
Query: 358 LDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAP 393
+++ +G LWILGDVFIRQ+++VFDR NN+VGLAP
Sbjct: 351 MNVPTESGELWILGDVFIRQYFTVFDRANNQVGLAP 386
>gi|4503143 cathepsin D preproprotein [Homo sapiens]
Length = 412
Score = 363 bits (932), Expect = e-100
Identities = 186/409 (45%), Positives = 254/409 (62%), Gaps = 15/409 (3%)
Query: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKL-RARSQLSEFWKSHNLDMIQFTES 59
M+ LL L L L +L R+PL + S+++ + + + +
Sbjct: 1 MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP 60
Query: 60 CSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCT--SPACKTH 117
+ E L NY+D +Y+G I IG+PPQ FTV+FDTGSSNLWVPS++C AC H
Sbjct: 61 AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120
Query: 118 SRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVE-----------GLTVVGQQFG 166
++ +SSTY + G SF I YG+GSLSG + D VSV G+ V Q FG
Sbjct: 121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG 180
Query: 167 ESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGG 226
E+ +PG TF+ A+FDGILG+ YP ++V V PVFDN+M Q LVD +FS Y+S +P+
Sbjct: 181 EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ 240
Query: 227 AGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSL 286
G EL+ GG D ++ GSL+++ VT++AYWQ+ LD ++V + C EGC+AIVDTGTSL
Sbjct: 241 PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL 300
Query: 287 ITGPSDKIKQLQNAIGAAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFV 345
+ GP D++++LQ AIGA P + GEY + C ++ +P +T + G Y LSP YTL
Sbjct: 301 MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ 360
Query: 346 DGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPA 394
G C SGF G+DI PP+GPLWILGDVFI ++Y+VFDR NNRVG A A
Sbjct: 361 AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEA 409
>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
Length = 388
Score = 353 bits (905), Expect = 2e-97
Identities = 183/393 (46%), Positives = 259/393 (65%), Gaps = 12/393 (3%)
Query: 5 LLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQ 64
++++LV L+L EA ++ +VPL++ S+++ ++ + L EF ++H D +
Sbjct: 4 MVVVLVCLQLLEA--AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSV 61
Query: 65 SAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQ 124
+ EP+ Y+D YFG ISIG+PPQNF V+FDTGSSNLWVPSVYC S AC +HSRF PS+
Sbjct: 62 TY-EPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSE 119
Query: 125 SSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGI 184
SSTYS GQ+FS+QYG+GSL+G G D ++V+ + V Q+FG S EPG FV A+FDGI
Sbjct: 120 SSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGI 179
Query: 185 LGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGS 244
+GL YP+L+V T M+ + + P+FSVY+ SN +G +G ++FGG D S ++G
Sbjct: 180 MGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYL-SNQQGSSGGAVVFGGVDSSLYTGQ 238
Query: 245 LNWVPVTKQAYWQIALDNIQVGGTVM-FCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGA 303
+ W PVT++ YWQI ++ +GG +CSEGCQAIVDTGTSL+T P + L A GA
Sbjct: 239 IYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGA 298
Query: 304 APVD-GEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHP 362
+ G++ V C ++ +P +TF INGV + L P++Y L +C+ G + +
Sbjct: 299 QEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYIL----SNNGYCTVGVEPTYLSS 354
Query: 363 PAG-PLWILGDVFIRQFYSVFDRGNNRVGLAPA 394
G PLWILGDVF+R +YSV+D GNNRVG A A
Sbjct: 355 QNGQPLWILGDVFLRSYYSVYDLGNNRVGFATA 387
>gi|4758754 napsin A preproprotein [Homo sapiens]
Length = 420
Score = 334 bits (856), Expect = 9e-92
Identities = 179/397 (45%), Positives = 249/397 (62%), Gaps = 12/397 (3%)
Query: 5 LLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQ 64
LLLLL LL + + +L R+PL R ++ L L W+ ++ + D+
Sbjct: 10 LLLLLPLLNVEPSGATLIRIPLHRVQPGRRILN----LLRGWREP-AELPKLGAPSPGDK 64
Query: 65 SAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCT--SPACKTHSRFQP 122
PL NY D++YFG I +G+PPQNFTV FDTGSSNLWVPS C S C H RF P
Sbjct: 65 PIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDP 124
Query: 123 SQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFD 182
SS++ G F+IQYGTG + GI+ D++++ G+ FGE++ EP F A FD
Sbjct: 125 KASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFD 184
Query: 183 GILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFS 242
GILGLG+P L+V GV P D ++ Q L+D P+FS Y++ +PE G EL+ GG D +H+
Sbjct: 185 GILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYI 244
Query: 243 GSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIG 302
L +VPVT AYWQI ++ ++VG + C++GC AI+DTGTSLITGP+++I+ L AIG
Sbjct: 245 PPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIG 304
Query: 303 AAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIH 361
P + GEY + C+ + +P V+F + GV + L+ Y + +G++ C SGFQ LD+
Sbjct: 305 GIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQALDVP 364
Query: 362 PPAGPLWILGDVFIRQFYSVFDRG----NNRVGLAPA 394
PPAGP WILGDVF+ + +VFDRG + RVGLA A
Sbjct: 365 PPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLARA 401
>gi|4506475 renin preproprotein [Homo sapiens]
Length = 406
Score = 287 bits (735), Expect = 1e-77
Identities = 143/377 (37%), Positives = 222/377 (58%), Gaps = 9/377 (2%)
Query: 23 RVPLRRHPSLKKKLRARS-QLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGT 81
R+ L+R PS+++ L+ R ++ + M + T + ++ L NY+D +Y+G
Sbjct: 33 RIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLG---NTTSSVILTNYMDTQYYGE 89
Query: 82 ISIGSPPQNFTVIFDTGSSNLWVPSVYCTS--PACKTHSRFQPSQSSTYSQPGQSFSIQY 139
I IG+PPQ F V+FDTGSSN+WVPS C+ AC H F S SS+Y G +++Y
Sbjct: 90 IGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY 149
Query: 140 GTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTP 199
TG++SG + D ++V G+TV Q FGE P F+ AEFDG++G+G+ A+G VTP
Sbjct: 150 STGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTP 208
Query: 200 VFDNMMAQNLVDLPMFSVYMSSNPEGGA--GSELIFGGYDHSHFSGSLNWVPVTKQAYWQ 257
+FDN+++Q ++ +FS Y + + E G +++ GG D H+ G+ +++ + K WQ
Sbjct: 209 IFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQ 268
Query: 258 IALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANL 317
I + + VG + + C +GC A+VDTG S I+G + I++L A+GA +Y V+C
Sbjct: 269 IQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEG 328
Query: 318 NVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQ 377
+PD++F + G YTL+ Y + + C+ +DI PP GP W LG FIR+
Sbjct: 329 PTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRK 388
Query: 378 FYSVFDRGNNRVGLAPA 394
FY+ FDR NNR+G A A
Sbjct: 389 FYTEFDRRNNRIGFALA 405
>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
[Homo sapiens]
Length = 501
Score = 104 bits (259), Expect = 2e-22
Identities = 95/351 (27%), Positives = 157/351 (44%), Gaps = 45/351 (12%)
Query: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Query: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVD-AEFDGILGLGYPSLAV- 194
Y G G +G D VS+ G V + ++TE + F++ + ++GILGL Y +A
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARP 190
Query: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPE---GGAGSELIFGGYDHSHFSGSLN 246
+ P FD+++ Q NL L + N G +I GG DHS ++GSL
Sbjct: 191 DDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLW 250
Query: 247 WVPVTKQAYWQIALDNIQVGG--TVMFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIG 302
+ P+ ++ Y+++ + +++ G M C E ++IVD+GT+ + P + +I
Sbjct: 251 YTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIK 310
Query: 303 AAP-----VDGEYAVE--------CANLNVMPDVTFTING------VPYTLSPTAY--TL 341
AA DG + E N+ P ++ + G T+ P Y +
Sbjct: 311 AASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPV 370
Query: 342 LDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
D C ++ G ++G V + FY VFDR R+G A
Sbjct: 371 EDVATSQDDC---YKFAISQSSTGT--VMGAVIMEGFYVVFDRARKRIGFA 416
>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
[Homo sapiens]
Length = 518
Score = 100 bits (250), Expect = 2e-21
Identities = 89/344 (25%), Positives = 155/344 (45%), Gaps = 35/344 (10%)
Query: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Y+ + IG+PPQ ++ DTGSSN V +P + F +SSTY G ++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG----TPHSYIDTYFDTERSSTYRSKGFDVTV 147
Query: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVDA-EFDGILGLGYPSLAV- 194
+Y GS +G +G D V++ +G ++ E F+ +++GILGL Y +LA
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKP 207
Query: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP 249
+ FD+++ Q N+ + M + G G L+ GG + S + G + + P
Sbjct: 208 SSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTP 267
Query: 250 VTKQAYWQIALDNIQVGGTV--MFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP 305
+ ++ Y+QI + +++GG + C E +AIVD+GT+L+ P + A+ A
Sbjct: 268 IKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS 327
Query: 306 VDGEYAVECANLNVMPDVTFTINGVPYTLSP-TAYTLLDFVDGMQFCSSGFQGLDIHP-- 362
+ E++ + + +T + P++ P + L D F + L I P
Sbjct: 328 LIPEFSDGFWTGSQL--ACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMM 385
Query: 363 --------------PAGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
P+ ++G + FY +FDR RVG A
Sbjct: 386 GAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 429
>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
[Homo sapiens]
Length = 468
Score = 98.6 bits (244), Expect = 9e-21
Identities = 85/329 (25%), Positives = 145/329 (44%), Gaps = 55/329 (16%)
Query: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Y+ + IG+PPQ ++ DTGSSN V +P + F +SSTY G ++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG----TPHSYIDTYFDTERSSTYRSKGFDVTV 147
Query: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVDA-EFDGILGLGYPSLAV- 194
+Y GS +G +G D V++ +G ++ E F+ +++GILGL Y +LA
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKP 207
Query: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP 249
+ FD+++ Q N+ + M + G G L+ GG + S + G + + P
Sbjct: 208 SSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTP 267
Query: 250 VTKQAYWQIALDNIQVGGTV--MFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP 305
+ ++ Y+QI + +++GG + C E +AIVD+GT+L+ P + A+ A
Sbjct: 268 IKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS 327
Query: 306 VDGEYAVECANLNVMPDVTFTINGVPYT--LSPTAYTLLDFVDGMQFCSSGFQGLDIHPP 363
+ L + P + +N Y +SP+ L
Sbjct: 328 L----------LYIQPMMGAGLNYECYRFGISPSTNAL---------------------- 355
Query: 364 AGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
++G + FY +FDR RVG A
Sbjct: 356 -----VIGATVMEGFYVIFDRAQKRVGFA 379
>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
[Homo sapiens]
Length = 396
Score = 95.9 bits (237), Expect = 6e-20
Identities = 69/246 (28%), Positives = 122/246 (49%), Gaps = 16/246 (6%)
Query: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Y+ + IG+PPQ ++ DTGSSN V +P + F +SSTY G ++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG----TPHSYIDTYFDTERSSTYRSKGFDVTV 147
Query: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVDA-EFDGILGLGYPSLAV- 194
+Y GS +G +G D V++ +G ++ E F+ +++GILGL Y +LA
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKP 207
Query: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP 249
+ FD+++ Q N+ + M + G G L+ GG + S + G + + P
Sbjct: 208 SSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTP 267
Query: 250 VTKQAYWQIALDNIQVGGTV--MFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP 305
+ ++ Y+QI + +++GG + C E +AIVD+GT+L+ P + A+ A
Sbjct: 268 IKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS 327
Query: 306 VDGEYA 311
+ E++
Sbjct: 328 LIPEFS 333
>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
[Homo sapiens]
Length = 476
Score = 93.6 bits (231), Expect = 3e-19
Identities = 89/344 (25%), Positives = 151/344 (43%), Gaps = 56/344 (16%)
Query: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Query: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVD-AEFDGILGLGYPSLA-- 193
Y G G +G D VS+ G V + ++TE + F++ + ++GILGL Y +A
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARL 190
Query: 194 VGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQ 253
G P+ + + ++ G +I GG DHS ++GSL + P+ ++
Sbjct: 191 CGAGFPLNQSEVLASV------------------GGSMIIGGIDHSLYTGSLWYTPIRRE 232
Query: 254 AYWQIALDNIQVGG--TVMFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP---- 305
Y+++ + +++ G M C E ++IVD+GT+ + P + +I AA
Sbjct: 233 WYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEK 292
Query: 306 -VDGEYAVE--------CANLNVMPDVTFTING------VPYTLSPTAY--TLLDFVDGM 348
DG + E N+ P ++ + G T+ P Y + D
Sbjct: 293 FPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQ 352
Query: 349 QFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
C ++ G ++G V + FY VFDR R+G A
Sbjct: 353 DDC---YKFAISQSSTGT--VMGAVIMEGFYVVFDRARKRIGFA 391
>gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo
sapiens]
Length = 87
Score = 86.7 bits (213), Expect = 3e-17
Identities = 40/78 (51%), Positives = 56/78 (71%), Gaps = 1/78 (1%)
Query: 265 VGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAP-VDGEYAVECANLNVMPDV 323
+ G + C+EGCQAIVDTGTSL+TGP+ I +Q+ IGA+ DG+ V C+ ++ +PD+
Sbjct: 1 MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI 60
Query: 324 TFTINGVPYTLSPTAYTL 341
FTINGV Y + P+AY L
Sbjct: 61 VFTINGVQYPVPPSAYIL 78
>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
[Homo sapiens]
Length = 457
Score = 74.7 bits (182), Expect = 1e-13
Identities = 82/347 (23%), Positives = 133/347 (38%), Gaps = 81/347 (23%)
Query: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Query: 138 QYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGV 197
Y G G +G D L +
Sbjct: 131 PYTQGKWEGELGTD----------------------------------------LPDDSL 150
Query: 198 TPVFDNMMAQ----NLVDLPMFSVYMSSNPE---GGAGSELIFGGYDHSHFSGSLNWVPV 250
P FD+++ Q NL L + N G +I GG DHS ++GSL + P+
Sbjct: 151 EPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPI 210
Query: 251 TKQAYWQIALDNIQVGG--TVMFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP- 305
++ Y+++ + +++ G M C E ++IVD+GT+ + P + +I AA
Sbjct: 211 RREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASS 270
Query: 306 ----VDGEYAVE--------CANLNVMPDVTFTING------VPYTLSPTAY--TLLDFV 345
DG + E N+ P ++ + G T+ P Y + D
Sbjct: 271 TEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVA 330
Query: 346 DGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
C ++ G ++G V + FY VFDR R+G A
Sbjct: 331 TSQDDC---YKFAISQSSTGT--VMGAVIMEGFYVVFDRARKRIGFA 372
>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
[Homo sapiens]
Length = 432
Score = 67.0 bits (162), Expect = 3e-11
Identities = 77/340 (22%), Positives = 125/340 (36%), Gaps = 92/340 (27%)
Query: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Query: 138 QYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGV 197
Y G G +G D + G G+P
Sbjct: 131 PYTQGKWEGELGTDL-------------------------------LCGAGFP------- 152
Query: 198 TPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQ 257
S G +I GG DHS ++GSL + P+ ++ Y++
Sbjct: 153 --------------------LNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYE 192
Query: 258 IALDNIQVGG--TVMFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP-----VDG 308
+ + +++ G M C E ++IVD+GT+ + P + +I AA DG
Sbjct: 193 VIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDG 252
Query: 309 EYAVE--------CANLNVMPDVTFTING------VPYTLSPTAY--TLLDFVDGMQFCS 352
+ E N+ P ++ + G T+ P Y + D C
Sbjct: 253 FWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDC- 311
Query: 353 SGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
++ G ++G V + FY VFDR R+G A
Sbjct: 312 --YKFAISQSSTGT--VMGAVIMEGFYVVFDRARKRIGFA 347
>gi|138175817 zinc finger protein 236 [Homo sapiens]
Length = 1845
Score = 33.1 bits (74), Expect = 0.45
Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 10/119 (8%)
Query: 81 TISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYG 140
T S GSP + I + +++ +PS SP+ + S S + ++
Sbjct: 1515 TSSSGSPQEITLTISELNTTSGSLPSTTPMSPSAISTQNLVMSSSGVGGDASVTLTLADT 1574
Query: 141 TGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTP 199
G LSG G D V++ +T GQQF +T+P G G G P + + TP
Sbjct: 1575 QGMLSG--GLDTVTL-NITSQGQQFPALLTDP-------SLSGQGGAGSPQVILVSHTP 1623
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 30.0 bits (66), Expect = 3.8
Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 2/46 (4%)
Query: 273 SEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLN 318
+ GC+ I D G + K+K L IG P+ + +EC LN
Sbjct: 383 ARGCEGITDHGVEYLAKNCTKLKSLD--IGKCPLVSDTGLECLALN 426
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 29.6 bits (65), Expect = 5.0
Identities = 16/55 (29%), Positives = 28/55 (50%)
Query: 76 MEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQ 130
++ F +I+ G P FT+ F+TG N+ P + PA K R S + +++
Sbjct: 2212 LKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAE 2266
>gi|82775371 coiled-coil domain containing 93 [Homo sapiens]
Length = 631
Score = 29.6 bits (65), Expect = 5.0
Identities = 26/96 (27%), Positives = 41/96 (42%), Gaps = 8/96 (8%)
Query: 2 KTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCS 61
KTL L +L + Q +L ++ + PS+ + LRA ++E KS +F C
Sbjct: 352 KTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQ---EFKAHCR 408
Query: 62 MDQSAKEPLINYLDMEYF-----GTISIGSPPQNFT 92
+ + + I L E T+S G PP T
Sbjct: 409 EEMTRLQQEIENLKAERAPRGDEKTLSSGEPPGTLT 444
>gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens]
Length = 832
Score = 29.3 bits (64), Expect = 6.5
Identities = 14/35 (40%), Positives = 21/35 (60%)
Query: 84 IGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118
I PP T+ +++ SS+L P+ +SPACK S
Sbjct: 385 INPPPVAGTISYNSTSSSLEQPNAGSSSPACKASS 419
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 29.3 bits (64), Expect = 6.5
Identities = 32/146 (21%), Positives = 55/146 (37%), Gaps = 15/146 (10%)
Query: 27 RRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEP--LINYLDMEYFGTISI 84
RR KK +RA + + WK +++ C + ++P L+ Y D I
Sbjct: 1299 RRVHDGKKSIRATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYR-----DI 1353
Query: 85 GSPPQNFTVIFDT-GSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGS 143
P +F + +T + N P +C R S + Y+ P + I T
Sbjct: 1354 IDTPMDFGTVRETLDAGNYDSPLEFCKD------IRLIFSNAKAYT-PNKRSKIYSMTLR 1406
Query: 144 LSGIIGADQVSVEGLTVVGQQFGESV 169
LS + + +GQ+F E +
Sbjct: 1407 LSALFEEKMKKISSDFKIGQKFNEKL 1432
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 29.3 bits (64), Expect = 6.5
Identities = 32/146 (21%), Positives = 55/146 (37%), Gaps = 15/146 (10%)
Query: 27 RRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEP--LINYLDMEYFGTISI 84
RR KK +RA + + WK +++ C + ++P L+ Y D I
Sbjct: 1299 RRVHDGKKSIRATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYR-----DI 1353
Query: 85 GSPPQNFTVIFDT-GSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGS 143
P +F + +T + N P +C R S + Y+ P + I T
Sbjct: 1354 IDTPMDFGTVRETLDAGNYDSPLEFCKD------IRLIFSNAKAYT-PNKRSKIYSMTLR 1406
Query: 144 LSGIIGADQVSVEGLTVVGQQFGESV 169
LS + + +GQ+F E +
Sbjct: 1407 LSALFEEKMKKISSDFKIGQKFNEKL 1432
>gi|26667219 eyes absent 1 isoform c [Homo sapiens]
Length = 557
Score = 28.9 bits (63), Expect = 8.5
Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 3/64 (4%)
Query: 121 QPSQSSTYSQPGQSFSI-QYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDA 179
Q + +TY QPGQ + I YG + G+ + G G F S +PGQ
Sbjct: 120 QATAYATYPQPGQPYGISSYGIKTEGGLSQSQSPGQTGFLSYGTSF--STPQPGQAPYSY 177
Query: 180 EFDG 183
+ G
Sbjct: 178 QMQG 181
>gi|59710085 hypothetical protein LOC146562 [Homo sapiens]
Length = 520
Score = 28.9 bits (63), Expect = 8.5
Identities = 13/46 (28%), Positives = 24/46 (52%), Gaps = 3/46 (6%)
Query: 104 VPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIG 149
VP+ T P C+ ++R + + S PG+ F +G +S ++G
Sbjct: 96 VPAELATEPGCRQNTRTKDASSQEGRDPGRPFE---SSGEVSALLG 138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,907,480
Number of Sequences: 37866
Number of extensions: 729494
Number of successful extensions: 1585
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1501
Number of HSP's gapped (non-prelim): 39
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.