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Search of human proteins with 4502617
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502617 cyclin D2 [Homo sapiens]
(289 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502617 cyclin D2 [Homo sapiens] 582 e-166
gi|16950655 cyclin D1 [Homo sapiens] 358 2e-99
gi|4502619 cyclin D3 isoform 2 [Homo sapiens] 351 4e-97
gi|209862835 cyclin D3 isoform 1 [Homo sapiens] 248 4e-66
gi|209915553 cyclin D3 isoform 3 [Homo sapiens] 166 2e-41
gi|4502613 cyclin A [Homo sapiens] 93 2e-19
gi|209915556 cyclin D3 isoform 4 [Homo sapiens] 89 4e-18
gi|17318565 cyclin E2 [Homo sapiens] 89 6e-18
gi|161377472 cyclin A1 isoform c [Homo sapiens] 88 8e-18
gi|161377470 cyclin A1 isoform c [Homo sapiens] 88 8e-18
gi|161377468 cyclin A1 isoform b [Homo sapiens] 88 8e-18
gi|4502611 cyclin A1 isoform a [Homo sapiens] 88 8e-18
gi|17318559 cyclin E1 isoform 1 [Homo sapiens] 80 2e-15
gi|17318561 cyclin E1 isoform 2 [Homo sapiens] 80 2e-15
gi|14327896 cyclin B1 [Homo sapiens] 70 2e-12
gi|4757930 cyclin B2 [Homo sapiens] 68 1e-11
gi|153791755 cyclin domain containing [Homo sapiens] 62 8e-10
gi|118572588 cyclin F [Homo sapiens] 62 8e-10
gi|5802992 cyclin I [Homo sapiens] 60 3e-09
gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Ho... 56 3e-08
gi|40805832 cyclin G1 [Homo sapiens] 54 1e-07
gi|4757934 cyclin G1 [Homo sapiens] 54 1e-07
gi|90669307 cyclin B3 isoform 3 [Homo sapiens] 54 2e-07
gi|197276674 cyclin J isoform 1 [Homo sapiens] 54 2e-07
gi|89886237 cyclin I family, member 2 [Homo sapiens] 50 2e-06
gi|4757936 cyclin G2 [Homo sapiens] 47 2e-05
gi|4502623 cyclin H [Homo sapiens] 44 2e-04
gi|94680985 cyclin J-like [Homo sapiens] 44 2e-04
gi|16306525 cyclin B3 isoform 1 [Homo sapiens] 44 2e-04
gi|197276676 cyclin J isoform 3 [Homo sapiens] 41 0.001
>gi|4502617 cyclin D2 [Homo sapiens]
Length = 289
Score = 582 bits (1501), Expect = e-166
Identities = 289/289 (100%), Positives = 289/289 (100%)
Query: 1 MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVA 60
MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVA
Sbjct: 1 MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVA 60
Query: 61 TWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTA 120
TWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTA
Sbjct: 61 TWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTA 120
Query: 121 EKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKH 180
EKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKH
Sbjct: 121 EKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKH 180
Query: 181 AQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDV 240
AQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDV
Sbjct: 181 AQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDV 240
Query: 241 DCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL 289
DCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
Sbjct: 241 DCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL 289
>gi|16950655 cyclin D1 [Homo sapiens]
Length = 295
Score = 358 bits (920), Expect = 2e-99
Identities = 181/293 (61%), Positives = 224/293 (76%), Gaps = 6/293 (2%)
Query: 2 ELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVAT 61
+LLC EV+ +RRA D NLL +DRVL+ +L EE P SYFKCVQK++ P MR++VAT
Sbjct: 4 QLLCCEVETIRRAYPDANLL-NDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVAT 62
Query: 62 WMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAE 121
WMLEVCEEQKCEEEVFPLAMNYLDRFL+ P KS LQLLGA CMF+ASK+KET PLTAE
Sbjct: 63 WMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAE 122
Query: 122 KLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHA 181
KLCIYTDNSI+P+ELL+ EL+++ KLKWNLAA+TPHDFIEH L K+P+ E +IRKHA
Sbjct: 123 KLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHA 182
Query: 182 QTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVD 241
QTF+ALCATD KF PPSM+A GSV AA+ GL + L+ LT L+++ D D
Sbjct: 183 QTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPD 242
Query: 242 CLKACQEQIEAVLLNSLQQYRQDQ-----RDGSKSEDELDQASTPTDVRDIDL 289
CL+ACQEQIEA+L +SL+Q +Q+ + + E+E+D A TPTDVRD+D+
Sbjct: 243 CLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI 295
>gi|4502619 cyclin D3 isoform 2 [Homo sapiens]
Length = 292
Score = 351 bits (901), Expect = 4e-97
Identities = 183/297 (61%), Positives = 227/297 (76%), Gaps = 13/297 (4%)
Query: 1 MELLCHE-VDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMV 59
MELLC E RA D LL D RVLQ+LL +EERY+P+ SYF+CVQ++I+P+MR+M+
Sbjct: 1 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML 60
Query: 60 ATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLT 119
A WMLEVCEEQ+CEEEVFPLAMNYLDR+L+ VPT K+ LQLLGAVCM LASKL+ET+PLT
Sbjct: 61 AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT 120
Query: 120 AEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRK 179
EKLCIYTD+++ P++L +WE++VLGKLKW+LAAV HDF+ IL +L R++ +L++K
Sbjct: 121 IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK 180
Query: 180 HAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTD 239
HAQTF+ALCATD+ FAMYPPSMIATGS+GAA+ GL S++ D LTELLA IT T+
Sbjct: 181 HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGL----GACSMSGDELTELLAGITGTE 236
Query: 240 VDCLKACQEQIEAVLLNSLQQYRQDQRD-------GSKSEDELDQASTPTDVRDIDL 289
VDCL+ACQEQIEA L SL++ Q GS S+ Q STPTDV I L
Sbjct: 237 VDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGP-SQTSTPTDVTAIHL 292
>gi|209862835 cyclin D3 isoform 1 [Homo sapiens]
Length = 211
Score = 248 bits (633), Expect = 4e-66
Identities = 130/216 (60%), Positives = 162/216 (75%), Gaps = 12/216 (5%)
Query: 81 MNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWE 140
MNYLDR+L+ VPT K+ LQLLGAVCM LASKL+ET+PLT EKLCIYTD+++ P++L +WE
Sbjct: 1 MNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWE 60
Query: 141 LVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPS 200
++VLGKLKW+LAAV HDF+ IL +L R++ +L++KHAQTF+ALCATD+ FAMYPPS
Sbjct: 61 VLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPS 120
Query: 201 MIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQQ 260
MIATGS+GAA+ GL S++ D LTELLA IT T+VDCL+ACQEQIEA L SL++
Sbjct: 121 MIATGSIGAAVQGL----GACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLRE 176
Query: 261 YRQDQRD-------GSKSEDELDQASTPTDVRDIDL 289
Q GS S+ Q STPTDV I L
Sbjct: 177 ASQTSSSPAPKAPRGSSSQGP-SQTSTPTDVTAIHL 211
>gi|209915553 cyclin D3 isoform 3 [Homo sapiens]
Length = 220
Score = 166 bits (420), Expect = 2e-41
Identities = 91/161 (56%), Positives = 113/161 (70%), Gaps = 12/161 (7%)
Query: 136 LLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFA 195
L +WE++VLGKLKW+LAAV HDF+ IL +L R++ +L++KHAQTF+ALCATD+ FA
Sbjct: 65 LEDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFA 124
Query: 196 MYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLL 255
MYPPSMIATGS+GAA+ GL S++ D LTELLA IT T+VDCL+ACQEQIEA L
Sbjct: 125 MYPPSMIATGSIGAAVQGL----GACSMSGDELTELLAGITGTEVDCLRACQEQIEAALR 180
Query: 256 NSLQQYRQDQRD-------GSKSEDELDQASTPTDVRDIDL 289
SL++ Q GS S+ Q STPTDV I L
Sbjct: 181 ESLREASQTSSSPAPKAPRGSSSQGP-SQTSTPTDVTAIHL 220
Score = 77.4 bits (189), Expect = 1e-14
Identities = 39/66 (59%), Positives = 50/66 (75%), Gaps = 1/66 (1%)
Query: 1 MELLCHE-VDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMV 59
MELLC E RA D LL D RVLQ+LL +EERY+P+ SYF+CVQ++I+P+MR+M+
Sbjct: 1 MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML 60
Query: 60 ATWMLE 65
A WMLE
Sbjct: 61 AYWMLE 66
>gi|4502613 cyclin A [Homo sapiens]
Length = 432
Score = 93.2 bits (230), Expect = 2e-19
Identities = 72/243 (29%), Positives = 120/243 (49%), Gaps = 14/243 (5%)
Query: 30 LLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLA 89
L +E + P+ Y K Q DI MR ++ W++EV EE K + E LA+NY+DRFL+
Sbjct: 186 LREMEVKCKPKVGYMK-KQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLS 244
Query: 90 GVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
+ + LQL+G M LASK +E P + TD++ +++L E +VL L +
Sbjct: 245 SMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 304
Query: 150 NLAAVTPHDFI-EHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVG 208
+LAA T + F+ ++ L + P + SL + ++L D + Y PS+IA +
Sbjct: 305 DLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGE--LSLIDAD-PYLKYLPSVIAGAAFH 361
Query: 209 AAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQQYRQDQRDG 268
A+ ++T + E L + T ++ LK C + L + Q +Q R+
Sbjct: 362 LAL---------YTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREK 412
Query: 269 SKS 271
K+
Sbjct: 413 YKN 415
>gi|209915556 cyclin D3 isoform 4 [Homo sapiens]
Length = 96
Score = 89.0 bits (219), Expect = 4e-18
Identities = 55/101 (54%), Positives = 64/101 (63%), Gaps = 12/101 (11%)
Query: 196 MYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLL 255
MYPPSMIATGS+GAA+ GL S++ D LTELLA IT T+VDCL+ACQEQIEA L
Sbjct: 1 MYPPSMIATGSIGAAVQGLG----ACSMSGDELTELLAGITGTEVDCLRACQEQIEAALR 56
Query: 256 NSLQQYRQDQRD-------GSKSEDELDQASTPTDVRDIDL 289
SL++ Q GS S+ Q STPTDV I L
Sbjct: 57 ESLREASQTSSSPAPKAPRGSSSQGP-SQTSTPTDVTAIHL 96
>gi|17318565 cyclin E2 [Homo sapiens]
Length = 404
Score = 88.6 bits (218), Expect = 6e-18
Identities = 53/161 (32%), Positives = 86/161 (53%), Gaps = 3/161 (1%)
Query: 29 NLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRF- 87
N+L E RY+ +F+ + D++P MR ++ W+LEVCE E F LA ++ DRF
Sbjct: 116 NMLKKESRYVHD-KHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFM 174
Query: 88 LAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKL 147
L K+ LQL+G +F+ASKL+E ++ TD + +++L EL++L L
Sbjct: 175 LTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKAL 234
Query: 148 KWNLAAVTPHDFIEHILR-KLPQQREKLSLIRKHAQTFIAL 187
KW L VT ++ L+ + K+ L + +TFI +
Sbjct: 235 KWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQI 275
>gi|161377472 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 88.2 bits (217), Expect = 8e-18
Identities = 63/189 (33%), Positives = 98/189 (51%), Gaps = 8/189 (4%)
Query: 24 DRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNY 83
+ + Q L E R+ P+ Y K Q DI MR ++ W++EV EE K E LA+N+
Sbjct: 169 EEIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 227
Query: 84 LDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVV 143
LDRFL+ + + LQL+G M LASK +E P ++ TD++ ++LL+ E ++
Sbjct: 228 LDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 287
Query: 144 LGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIA 203
L L ++L T + F+ LR+ +L + A+ ++L D F Y PS+IA
Sbjct: 288 LKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAE--LSLLEAD-PFLKYLPSLIA 344
Query: 204 TGSVGAAIC 212
AA C
Sbjct: 345 ----AAAFC 349
>gi|161377470 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 88.2 bits (217), Expect = 8e-18
Identities = 63/189 (33%), Positives = 98/189 (51%), Gaps = 8/189 (4%)
Query: 24 DRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNY 83
+ + Q L E R+ P+ Y K Q DI MR ++ W++EV EE K E LA+N+
Sbjct: 169 EEIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 227
Query: 84 LDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVV 143
LDRFL+ + + LQL+G M LASK +E P ++ TD++ ++LL+ E ++
Sbjct: 228 LDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 287
Query: 144 LGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIA 203
L L ++L T + F+ LR+ +L + A+ ++L D F Y PS+IA
Sbjct: 288 LKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAE--LSLLEAD-PFLKYLPSLIA 344
Query: 204 TGSVGAAIC 212
AA C
Sbjct: 345 ----AAAFC 349
>gi|161377468 cyclin A1 isoform b [Homo sapiens]
Length = 464
Score = 88.2 bits (217), Expect = 8e-18
Identities = 63/189 (33%), Positives = 98/189 (51%), Gaps = 8/189 (4%)
Query: 24 DRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNY 83
+ + Q L E R+ P+ Y K Q DI MR ++ W++EV EE K E LA+N+
Sbjct: 212 EEIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 270
Query: 84 LDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVV 143
LDRFL+ + + LQL+G M LASK +E P ++ TD++ ++LL+ E ++
Sbjct: 271 LDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 330
Query: 144 LGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIA 203
L L ++L T + F+ LR+ +L + A+ ++L D F Y PS+IA
Sbjct: 331 LKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAE--LSLLEAD-PFLKYLPSLIA 387
Query: 204 TGSVGAAIC 212
AA C
Sbjct: 388 ----AAAFC 392
>gi|4502611 cyclin A1 isoform a [Homo sapiens]
Length = 465
Score = 88.2 bits (217), Expect = 8e-18
Identities = 63/189 (33%), Positives = 98/189 (51%), Gaps = 8/189 (4%)
Query: 24 DRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNY 83
+ + Q L E R+ P+ Y K Q DI MR ++ W++EV EE K E LA+N+
Sbjct: 213 EEIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNF 271
Query: 84 LDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVV 143
LDRFL+ + + LQL+G M LASK +E P ++ TD++ ++LL+ E ++
Sbjct: 272 LDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 331
Query: 144 LGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIA 203
L L ++L T + F+ LR+ +L + A+ ++L D F Y PS+IA
Sbjct: 332 LKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAE--LSLLEAD-PFLKYLPSLIA 388
Query: 204 TGSVGAAIC 212
AA C
Sbjct: 389 ----AAAFC 393
>gi|17318559 cyclin E1 isoform 1 [Homo sapiens]
Length = 410
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/198 (28%), Positives = 94/198 (47%), Gaps = 21/198 (10%)
Query: 24 DRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNY 83
+ V + +L E+ YL +F +QP MR ++ W++EVCE K E F LA ++
Sbjct: 114 EEVWKIMLNKEKTYLRD-QHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDF 172
Query: 84 LDRFLAGVPTP-KSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELV 142
DR++A K+ LQL+G +F+A+KL+E P + TD + E+L EL+
Sbjct: 173 FDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELM 232
Query: 143 VLGKLKWNLAAVT-------------PHDFIEHILRKLPQQREKLSLIRKHAQTFIALCA 189
++ LKW L+ +T +D E +L + PQQ I + LC
Sbjct: 233 IMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQ------IFIQIAELLDLCV 286
Query: 190 TDFKFAMYPPSMIATGSV 207
D +P ++A ++
Sbjct: 287 LDVDCLEFPYGILAASAL 304
>gi|17318561 cyclin E1 isoform 2 [Homo sapiens]
Length = 395
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/198 (28%), Positives = 94/198 (47%), Gaps = 21/198 (10%)
Query: 24 DRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNY 83
+ V + +L E+ YL +F +QP MR ++ W++EVCE K E F LA ++
Sbjct: 99 EEVWKIMLNKEKTYLRD-QHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDF 157
Query: 84 LDRFLAGVPTP-KSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELV 142
DR++A K+ LQL+G +F+A+KL+E P + TD + E+L EL+
Sbjct: 158 FDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELM 217
Query: 143 VLGKLKWNLAAVT-------------PHDFIEHILRKLPQQREKLSLIRKHAQTFIALCA 189
++ LKW L+ +T +D E +L + PQQ I + LC
Sbjct: 218 IMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQ------IFIQIAELLDLCV 271
Query: 190 TDFKFAMYPPSMIATGSV 207
D +P ++A ++
Sbjct: 272 LDVDCLEFPYGILAASAL 289
>gi|14327896 cyclin B1 [Homo sapiens]
Length = 433
Score = 70.1 bits (170), Expect = 2e-12
Identities = 45/175 (25%), Positives = 82/175 (46%), Gaps = 4/175 (2%)
Query: 49 KDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFL 108
+++ MR ++ W+++V + + +E + ++ +DRF+ PK LQL+G MF+
Sbjct: 195 REVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFI 254
Query: 109 ASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLP 168
ASK +E P TDN+ ++ + E+ +L L + L P F+ +
Sbjct: 255 ASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGE 314
Query: 169 QQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSL 223
E+ +L A+ + L D+ +PPS IA G+ A+ L E +L
Sbjct: 315 VDVEQHTL----AKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTL 365
>gi|4757930 cyclin B2 [Homo sapiens]
Length = 398
Score = 67.8 bits (164), Expect = 1e-11
Identities = 42/158 (26%), Positives = 74/158 (46%), Gaps = 4/158 (2%)
Query: 49 KDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFL 108
+DI MR ++ W+++V + + +E + + +DRFL P + LQL+G + L
Sbjct: 159 RDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLL 218
Query: 109 ASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLP 168
ASK +E E TDN+ ++ E E ++L +LK+ L P F+ +
Sbjct: 219 ASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGE 278
Query: 169 QQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGS 206
E+ +L A+ + L D+ Y PS +A +
Sbjct: 279 VDVEQHTL----AKYLMELTLIDYDMVHYHPSKVAAAA 312
>gi|153791755 cyclin domain containing [Homo sapiens]
Length = 350
Score = 61.6 bits (148), Expect = 8e-10
Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 4/160 (2%)
Query: 48 QKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMF 107
Q + R + +W++ V + E L +N LDRFL P QLLG +
Sbjct: 125 QPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRFLTTTPVAADCFQLLGVTSLL 184
Query: 108 LASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHI--LR 165
+A K E P ++L + Q+L E +VL KL + L A T F+EH R
Sbjct: 185 IACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKLHFTLGAPTISFFLEHFTHAR 244
Query: 166 KLPQQREKLSLIRKH--AQTFIALCATDFKFAMYPPSMIA 203
Q E + A+ L D+ F Y PS++A
Sbjct: 245 VEAGQAEASEALEAQALARGVAELSLADYAFTSYSPSLLA 284
>gi|118572588 cyclin F [Homo sapiens]
Length = 786
Score = 61.6 bits (148), Expect = 8e-10
Identities = 54/235 (22%), Positives = 105/235 (44%), Gaps = 11/235 (4%)
Query: 47 VQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCM 106
VQK + MR ++ W++EV + L + +DR+L P+ LQLLG CM
Sbjct: 301 VQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACM 360
Query: 107 FLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRK 166
+ ++ LT + TDN+ K ++L+ ++ L+ + T D+ E +L
Sbjct: 361 VICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTL 420
Query: 167 LPQQREKLSLIRKHAQTFIA-LCATDFKFAMYPPSMIATGSVGAAICGLQQDE----EVS 221
+P + L +H +F+ L + Y P+ +A ++ A Q + ++
Sbjct: 421 VP-----VELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLW 475
Query: 222 SLTCDALTELLAKITNTDVDCL-KACQEQIEAVLLNSLQQYRQDQRDGSKSEDEL 275
LT + +L+ + + C + V L +++Q +D+R G S++E+
Sbjct: 476 DLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEV 530
>gi|5802992 cyclin I [Homo sapiens]
Length = 377
Score = 59.7 bits (143), Expect = 3e-09
Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 3/121 (2%)
Query: 49 KDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFL 108
+++ P R V W+ ++ + E F LA + LDRFLA V +L + C FL
Sbjct: 38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFL 97
Query: 109 ASKLKETSPLTAEKLCIYTDN--SIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRK 166
A+K E + D+ E+L E ++L KL W+L TP DF+ HI
Sbjct: 98 AAKTVEEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFL-HIFHA 156
Query: 167 L 167
+
Sbjct: 157 I 157
>gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Homo
sapiens]
Length = 307
Score = 56.2 bits (134), Expect = 3e-08
Identities = 32/107 (29%), Positives = 55/107 (51%)
Query: 45 KCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAV 104
+ + + + P MR +V W+++V E + LA++ LD +L+ LQLLG
Sbjct: 97 RALPRAVTPEMRALVVDWLVQVHEYLGLAGDTLYLAVHLLDSYLSAGRVRLHRLQLLGVA 156
Query: 105 CMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNL 151
C+F+A K++E LC+ + +S ELL E +L +L + L
Sbjct: 157 CLFVACKMEECVLPEPAFLCLLSADSFSRAELLRAERRILSRLDFRL 203
>gi|40805832 cyclin G1 [Homo sapiens]
Length = 295
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 11/161 (6%)
Query: 73 EEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETS---PLTAEKLCIYTDN 129
+ E F LA+N LDRFL+ + HL +G C +LA K E PL + + I +
Sbjct: 69 DTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRI-SQY 127
Query: 130 SIKPQELLEWELVVLGKLKWNLAAVTPHDFIE----HILRKLP-QQREKLSLIRKHAQTF 184
+L+ E +VL K+ W + A T F++ + LP ++R ++ R AQ
Sbjct: 128 RFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQ-- 185
Query: 185 IALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTC 225
+ C F+ PS++A + I + E + C
Sbjct: 186 LKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIEC 226
>gi|4757934 cyclin G1 [Homo sapiens]
Length = 295
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 11/161 (6%)
Query: 73 EEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETS---PLTAEKLCIYTDN 129
+ E F LA+N LDRFL+ + HL +G C +LA K E PL + + I +
Sbjct: 69 DTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRI-SQY 127
Query: 130 SIKPQELLEWELVVLGKLKWNLAAVTPHDFIE----HILRKLP-QQREKLSLIRKHAQTF 184
+L+ E +VL K+ W + A T F++ + LP ++R ++ R AQ
Sbjct: 128 RFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQ-- 185
Query: 185 IALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTC 225
+ C F+ PS++A + I + E + C
Sbjct: 186 LKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIEC 226
>gi|90669307 cyclin B3 isoform 3 [Homo sapiens]
Length = 1395
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/131 (25%), Positives = 61/131 (46%)
Query: 48 QKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMF 107
Q +I MR ++ W++EV + E LA+ +D +L K LQLLGA
Sbjct: 1153 QIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFM 1212
Query: 108 LASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKL 167
+A+K +E + + D++ + E+L E+ +L LK ++ + F+ R +
Sbjct: 1213 IAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCI 1272
Query: 168 PQQREKLSLIR 178
+ L+L R
Sbjct: 1273 HTNMKTLTLSR 1283
>gi|197276674 cyclin J isoform 1 [Homo sapiens]
Length = 383
Score = 53.9 bits (128), Expect = 2e-07
Identities = 46/151 (30%), Positives = 68/151 (45%), Gaps = 19/151 (12%)
Query: 79 LAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKL--KETSPLTAEKL----CIYTDNSI- 131
LA+ LD F+ L L+ C+ LASK KE S E+L C+ N +
Sbjct: 63 LAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNLVL 122
Query: 132 KPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQR-----------EKLSL-IRK 179
Q LL EL++L +WNL T FIE+ L + + EK L + K
Sbjct: 123 TKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHETDLHDGWPMICLEKTKLYMAK 182
Query: 180 HAQTFIALCATDFKFAMYPPSMIATGSVGAA 210
+A F+ + D+ F Y PS++A V ++
Sbjct: 183 YADYFLEVSLQDYAFLNYAPSLVAAACVASS 213
>gi|89886237 cyclin I family, member 2 [Homo sapiens]
Length = 369
Score = 50.4 bits (119), Expect = 2e-06
Identities = 50/214 (23%), Positives = 83/214 (38%), Gaps = 23/214 (10%)
Query: 59 VATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPL 118
V W+L + + F LA+ R L V + +L + LA+K+ E
Sbjct: 153 VVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEF 212
Query: 119 TAE--KLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFI-----------EHILR 165
+ + + P ELL EL +L +L W+L TP DF+ H+L
Sbjct: 213 IPQVKDFTKHYGSDYSPNELLRMELAILDRLHWDLYIGTPLDFLTIFHALVVLSWPHVLE 272
Query: 166 KLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTC 225
LPQ+ L + Q + C + + GS A + + E + C
Sbjct: 273 LLPQRNPSLHVASLTRQ--LQHCMAGHQLLQF------KGSTLALVIITLELERLMPGWC 324
Query: 226 DALTELLAKITNTDVDCLKACQEQIEAVLLNSLQ 259
+++LL K D+ +C +++ L SLQ
Sbjct: 325 APISDLLKKAQVGDMQ--YSCCKELVMQQLRSLQ 356
>gi|4757936 cyclin G2 [Homo sapiens]
Length = 344
Score = 47.0 bits (110), Expect = 2e-05
Identities = 51/178 (28%), Positives = 82/178 (46%), Gaps = 25/178 (14%)
Query: 75 EVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETS---PLTAEKLCIYTDNSI 131
E F LA+N LDRFLA + HL +G LA+++ E P T + + I +
Sbjct: 75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRI-SQCKC 133
Query: 132 KPQELLEWELVVLGKLKWNLAAVTPHDFIE----HILRKLPQQREKLSLIRKHAQTFIAL 187
++ E ++ KL + L A T +F+ IL +++E LSL + AQ +
Sbjct: 134 TASDIKRMEKIISEKLHYELEATTALNFLHLYHTIILCHTSERKEILSLDKLEAQ--LKA 191
Query: 188 CATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELL------AKITNTD 239
C F+ PS++ A+C L + EV +L L E+L +KI +T+
Sbjct: 192 CNCRLIFSKAKPSVL-------ALCLL--NLEVETLKSVELLEILLLVKKHSKINDTE 240
>gi|4502623 cyclin H [Homo sapiens]
Length = 323
Score = 43.9 bits (102), Expect = 2e-04
Identities = 45/179 (25%), Positives = 74/179 (41%), Gaps = 29/179 (16%)
Query: 63 MLEVCEEQK--CEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKE------ 114
+LE C K V A Y RF + H +++ C FLA K+ E
Sbjct: 64 LLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSP 123
Query: 115 -------TSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKL 167
SPL EK +++LE+EL+++ +L ++L P+ E L L
Sbjct: 124 QFVGNLRESPLGQEKAL---------EQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDL 174
Query: 168 PQQR---EKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSV--GAAICGLQQDEEVS 221
+ E ++RK A F+ A + +Y PS IA ++ A+ G+ + +S
Sbjct: 175 KTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLS 233
>gi|94680985 cyclin J-like [Homo sapiens]
Length = 435
Score = 43.9 bits (102), Expect = 2e-04
Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 21/143 (14%)
Query: 130 SIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQ-------------REKLSL 176
++ +ELL EL++L WNL TP F+++ L Q R+
Sbjct: 169 TLTKKELLSTELLLLEAFSWNLCLPTPAHFLDYYLLASVSQKDHHCHTWPTTCPRKTKEC 228
Query: 177 IRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKIT 236
++++A F+ + D F + PS++A VGA+ LQ T L +I+
Sbjct: 229 LKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQ--------LSPYWTRDLQRIS 280
Query: 237 NTDVDCLKACQEQIEAVLLNSLQ 259
+ ++ L C E + V N L+
Sbjct: 281 SYSLEHLSTCIEILLVVYDNVLK 303
>gi|16306525 cyclin B3 isoform 1 [Homo sapiens]
Length = 291
Score = 43.5 bits (101), Expect = 2e-04
Identities = 27/104 (25%), Positives = 48/104 (46%)
Query: 75 EVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQ 134
E LA+ +D +L K LQLLGA +A+K +E + + D++ +
Sbjct: 76 ETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRS 135
Query: 135 ELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIR 178
E+L E+ +L LK ++ + F+ R + + L+L R
Sbjct: 136 EVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSR 179
>gi|197276676 cyclin J isoform 3 [Homo sapiens]
Length = 371
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/93 (35%), Positives = 44/93 (47%), Gaps = 7/93 (7%)
Query: 79 LAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKL--KETSPLTAEKL----CIYTDNSI- 131
LA+ LD F+ L L+ C+ LASK KE S E+L C+ N +
Sbjct: 63 LAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTNMNLVL 122
Query: 132 KPQELLEWELVVLGKLKWNLAAVTPHDFIEHIL 164
Q LL EL++L +WNL T FIE+ L
Sbjct: 123 TKQNLLHMELLLLETFQWNLCLPTAAHFIEYYL 155
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,143,764
Number of Sequences: 37866
Number of extensions: 473495
Number of successful extensions: 1137
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1086
Number of HSP's gapped (non-prelim): 42
length of query: 289
length of database: 18,247,518
effective HSP length: 101
effective length of query: 188
effective length of database: 14,423,052
effective search space: 2711533776
effective search space used: 2711533776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.