Guide to the Human Genome
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Search of human proteins with 4502477

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
         (569 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502477 beta-transducin repeat containing protein isoform 2 [...  1173   0.0  
gi|16117783 beta-transducin repeat containing protein isoform 1 ...  1155   0.0  
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...   919   0.0  
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...   915   0.0  
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...   912   0.0  
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   237   2e-62
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   237   2e-62
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   237   2e-62
gi|32189425 WD repeat domain 69 [Homo sapiens]                        144   2e-34
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   129   7e-30
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]           126   6e-29
gi|157266266 WD repeat domain 86 [Homo sapiens]                       122   7e-28
gi|16554629 WD repeat domain 5 [Homo sapiens]                         122   9e-28
gi|16554627 WD repeat domain 5 [Homo sapiens]                         122   9e-28
gi|23199987 WD repeat domain 5B [Homo sapiens]                        121   2e-27
gi|19913369 transducin beta-like 3 [Homo sapiens]                     111   2e-24
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           110   3e-24
gi|113865883 WD repeat domain 38 [Homo sapiens]                       109   8e-24
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    106   7e-23
gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens]   103   4e-22
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    102   7e-22
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...   101   2e-21
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     99   8e-21
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     99   8e-21
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     99   8e-21
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    99   1e-20
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]               96   9e-20
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)...    96   1e-19
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          96   1e-19
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          96   1e-19

>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score = 1173 bits (3034), Expect = 0.0
 Identities = 569/569 (100%), Positives = 569/569 (100%)

Query: 1   MDPAEAVLQEKALKFMNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLA 60
           MDPAEAVLQEKALKFMNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLA
Sbjct: 1   MDPAEAVLQEKALKFMNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLA 60

Query: 61  STAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHL 120
           STAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHL
Sbjct: 61  STAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHL 120

Query: 121 ISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWY 180
           ISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWY
Sbjct: 121 ISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWY 180

Query: 181 RVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKII 240
           RVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKII
Sbjct: 181 RVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKII 240

Query: 241 QDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECK 300
           QDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECK
Sbjct: 241 QDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECK 300

Query: 301 RILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMM 360
           RILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMM
Sbjct: 301 RILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMM 360

Query: 361 VTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTC 420
           VTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTC
Sbjct: 361 VTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTC 420

Query: 421 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 480
           EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN
Sbjct: 421 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 480

Query: 481 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDT 540
           KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDT
Sbjct: 481 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDT 540

Query: 541 ILIWDFLNDPAAQAEPPRSPSRTYTYISR 569
           ILIWDFLNDPAAQAEPPRSPSRTYTYISR
Sbjct: 541 ILIWDFLNDPAAQAEPPRSPSRTYTYISR 569


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score = 1155 bits (2987), Expect = 0.0
 Identities = 569/605 (94%), Positives = 569/605 (94%), Gaps = 36/605 (5%)

Query: 1   MDPAEAVLQEKALKFM------------------------------------NSSEREDC 24
           MDPAEAVLQEKALKFM                                    NSSEREDC
Sbjct: 1   MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDC 60

Query: 25  NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV 84
           NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV
Sbjct: 61  NNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIV 120

Query: 85  PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF 144
           PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF
Sbjct: 121 PKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDF 180

Query: 145 ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR 204
           ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR
Sbjct: 181 ITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWR 240

Query: 205 GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS 264
           GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS
Sbjct: 241 GLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRS 300

Query: 265 ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS 324
           ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS
Sbjct: 301 ETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGS 360

Query: 325 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 384
           SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR
Sbjct: 361 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 420

Query: 385 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV 444
           VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV
Sbjct: 421 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVV 480

Query: 445 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR 504
           SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR
Sbjct: 481 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPR 540

Query: 505 APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY 564
           APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY
Sbjct: 541 APAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTY 600

Query: 565 TYISR 569
           TYISR
Sbjct: 601 TYISR 605


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score =  919 bits (2376), Expect = 0.0
 Identities = 451/569 (79%), Positives = 494/569 (86%), Gaps = 40/569 (7%)

Query: 1   MDPAEAVLQEKALKFMNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLA 60
           M+P ++V+++K ++ MN+S  ED N  E P+K     N+L Q                  
Sbjct: 1   MEP-DSVIEDKTIELMNTSVMEDQNEDESPKK-----NTLWQ------------------ 36

Query: 61  STAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHL 120
                         ++NGTSS+IV ++R    +Y+KEK+LC+KYF+QWSESDQVEFVEHL
Sbjct: 37  --------------ISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHL 82

Query: 121 ISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWY 180
           IS+MCHYQHGHINSYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW 
Sbjct: 83  ISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQ 142

Query: 181 RVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKII 240
           RV S+GMLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+P DG  PPNSFYR+LYPKII
Sbjct: 143 RVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKII 200

Query: 241 QDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECK 300
           QDIETIESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC 
Sbjct: 201 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 260

Query: 301 RILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMM 360
           ++LTGHTGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+M
Sbjct: 261 KVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLM 320

Query: 361 VTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTC 420
           VTCSKDRSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTC
Sbjct: 321 VTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTC 380

Query: 421 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 480
           EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN
Sbjct: 381 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 440

Query: 481 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDT 540
           KRIVSGAYDGKIKVWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDT
Sbjct: 441 KRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDT 500

Query: 541 ILIWDFLNDPAAQAEPPRSPSRTYTYISR 569
           ILIWDFLN P +     RSPSRTYTYISR
Sbjct: 501 ILIWDFLNVPPSAQNETRSPSRTYTYISR 529


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score =  915 bits (2366), Expect = 0.0
 Identities = 443/529 (83%), Positives = 483/529 (91%), Gaps = 6/529 (1%)

Query: 41  RQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKEL 100
           R  +  CA L    E++C A + +++   V   +++NGTSS+IV ++R    +Y+KEK+L
Sbjct: 20  RSLWLGCANLV---ESMC-ALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDL 75

Query: 101 CVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENI 160
           C+KYF+QWSESDQVEFVEHLIS+MCHYQHGHINSYLKPMLQRDFITALP +GLDHIAENI
Sbjct: 76  CIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENI 135

Query: 161 LSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNK 220
           LSYLDA+SLCAAELVCKEW RV S+GMLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+
Sbjct: 136 LSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNR 195

Query: 221 PPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKI 280
           P DG  PPNSFYR+LYPKIIQDIETIESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI
Sbjct: 196 PTDG--PPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 253

Query: 281 VSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEML 340
           +SGLRDN+IKIWDK +LEC ++LTGHTGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+L
Sbjct: 254 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 313

Query: 341 NTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD 400
           NTLIHH EAVLHLRF+NG+MVTCSKDRSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDD
Sbjct: 314 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 373

Query: 401 KYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 460
           KYIVSASGDRTIKVW+TSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG
Sbjct: 374 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 433

Query: 461 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 520
           ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL AALDPRAPA TLCLRTLVEHSG
Sbjct: 434 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 493

Query: 521 RVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR 569
           RVFRLQFDEFQI+SSSHDDTILIWDFLN P +     RSPSRTYTYISR
Sbjct: 494 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 542


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score =  912 bits (2356), Expect = 0.0
 Identities = 436/503 (86%), Positives = 470/503 (93%), Gaps = 2/503 (0%)

Query: 67  ENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCH 126
           E+   +  ++NGTSS+IV ++R    +Y+KEK+LC+KYF+QWSESDQVEFVEHLIS+MCH
Sbjct: 8   EDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCH 67

Query: 127 YQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDG 186
           YQHGHINSYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW RV S+G
Sbjct: 68  YQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEG 127

Query: 187 MLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETI 246
           MLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+P DG  PPNSFYR+LYPKIIQDIETI
Sbjct: 128 MLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKIIQDIETI 185

Query: 247 ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGH 306
           ESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC ++LTGH
Sbjct: 186 ESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH 245

Query: 307 TGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKD 366
           TGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+MVTCSKD
Sbjct: 246 TGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKD 305

Query: 367 RSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTL 426
           RSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTCEFVRTL
Sbjct: 306 RSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTL 365

Query: 427 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 486
           NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG
Sbjct: 366 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 425

Query: 487 AYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF 546
           AYDGKIKVWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDTILIWDF
Sbjct: 426 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDF 485

Query: 547 LNDPAAQAEPPRSPSRTYTYISR 569
           LN P +     RSPSRTYTYISR
Sbjct: 486 LNVPPSAQNETRSPSRTYTYISR 508


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  237 bits (604), Expect = 2e-62
 Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)

Query: 102 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 161
           +K F+ WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP      +A  +L
Sbjct: 120 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 175

Query: 162 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 221
           S+L+ K L  A   C+ W  +  D +LW++  +     + L     +RR         KP
Sbjct: 176 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 226

Query: 222 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 281
              ++P  S Y   +         I++NWR G     ++  +      + CLQ+   +IV
Sbjct: 227 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 277

Query: 282 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 341
           SG  DNT+K+W   T +C R L GHTG V   Q  + +II+GS+D T++VW+  TGE ++
Sbjct: 278 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 337

Query: 342 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 401
           TL  H   V  +  +   +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D +
Sbjct: 338 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 394

Query: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 461
            +VS + D  +KVW+  T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G 
Sbjct: 395 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 454

Query: 462 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 518
           C+  L GH+ L   +   +  +VSG  D  +K+WD+             CL+TL    +H
Sbjct: 455 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 505

Query: 519 SGRVFRLQFDEFQIVSSSHDDTILIWD 545
              V  LQF++  +++SS D T+ +WD
Sbjct: 506 QSAVTCLQFNKNFVITSSDDGTVKLWD 532



 Score =  152 bits (385), Expect = 6e-37
 Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)

Query: 260 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 319
           IH     +  V C+   ++++VSG RD T+++WD  T +C  +L GH  +V C+QYD R 
Sbjct: 336 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 395

Query: 320 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 379
           +++G+ D  V+VWD  T   L+TL  H   V  L+F+   +V+ S D SI VWD+ +   
Sbjct: 396 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 455

Query: 380 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 436
           I     L GH++  + ++  D  +VS + D T+K+W+  T + ++TL G   H+  + CL
Sbjct: 456 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 512

Query: 437 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 485
           Q+    V++ S D T++LWD++ G  +R L      G   +V  IR  N ++V      +
Sbjct: 513 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 572

Query: 486 GAYDGKIKVWD 496
           G  + K+ V D
Sbjct: 573 GTEETKLLVLD 583



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)

Query: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 311
           LQ +   ++    V CLQ++   +++   D T+K+WD  T E  R L    +G +G V+
Sbjct: 496 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 554


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  237 bits (604), Expect = 2e-62
 Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)

Query: 102 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 161
           +K F+ WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP      +A  +L
Sbjct: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293

Query: 162 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 221
           S+L+ K L  A   C+ W  +  D +LW++  +     + L     +RR         KP
Sbjct: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 344

Query: 222 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 281
              ++P  S Y   +         I++NWR G     ++  +      + CLQ+   +IV
Sbjct: 345 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 395

Query: 282 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 341
           SG  DNT+K+W   T +C R L GHTG V   Q  + +II+GS+D T++VW+  TGE ++
Sbjct: 396 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 455

Query: 342 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 401
           TL  H   V  +  +   +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D +
Sbjct: 456 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 512

Query: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 461
            +VS + D  +KVW+  T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G 
Sbjct: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 572

Query: 462 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 518
           C+  L GH+ L   +   +  +VSG  D  +K+WD+             CL+TL    +H
Sbjct: 573 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 623

Query: 519 SGRVFRLQFDEFQIVSSSHDDTILIWD 545
              V  LQF++  +++SS D T+ +WD
Sbjct: 624 QSAVTCLQFNKNFVITSSDDGTVKLWD 650



 Score =  152 bits (385), Expect = 6e-37
 Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)

Query: 260 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 319
           IH     +  V C+   ++++VSG RD T+++WD  T +C  +L GH  +V C+QYD R 
Sbjct: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 513

Query: 320 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 379
           +++G+ D  V+VWD  T   L+TL  H   V  L+F+   +V+ S D SI VWD+ +   
Sbjct: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 573

Query: 380 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 436
           I     L GH++  + ++  D  +VS + D T+K+W+  T + ++TL G   H+  + CL
Sbjct: 574 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630

Query: 437 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 485
           Q+    V++ S D T++LWD++ G  +R L      G   +V  IR  N ++V      +
Sbjct: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690

Query: 486 GAYDGKIKVWD 496
           G  + K+ V D
Sbjct: 691 GTEETKLLVLD 701



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)

Query: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 311
           LQ +   ++    V CLQ++   +++   D T+K+WD  T E  R L    +G +G V+
Sbjct: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  237 bits (604), Expect = 2e-62
 Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)

Query: 102 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 161
           +K F+ WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP      +A  +L
Sbjct: 158 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 213

Query: 162 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 221
           S+L+ K L  A   C+ W  +  D +LW++  +     + L     +RR         KP
Sbjct: 214 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 264

Query: 222 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 281
              ++P  S Y   +         I++NWR G     ++  +      + CLQ+   +IV
Sbjct: 265 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 315

Query: 282 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 341
           SG  DNT+K+W   T +C R L GHTG V   Q  + +II+GS+D T++VW+  TGE ++
Sbjct: 316 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 375

Query: 342 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 401
           TL  H   V  +  +   +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D +
Sbjct: 376 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 432

Query: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 461
            +VS + D  +KVW+  T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G 
Sbjct: 433 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 492

Query: 462 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 518
           C+  L GH+ L   +   +  +VSG  D  +K+WD+             CL+TL    +H
Sbjct: 493 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 543

Query: 519 SGRVFRLQFDEFQIVSSSHDDTILIWD 545
              V  LQF++  +++SS D T+ +WD
Sbjct: 544 QSAVTCLQFNKNFVITSSDDGTVKLWD 570



 Score =  152 bits (385), Expect = 6e-37
 Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)

Query: 260 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 319
           IH     +  V C+   ++++VSG RD T+++WD  T +C  +L GH  +V C+QYD R 
Sbjct: 374 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 433

Query: 320 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 379
           +++G+ D  V+VWD  T   L+TL  H   V  L+F+   +V+ S D SI VWD+ +   
Sbjct: 434 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 493

Query: 380 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 436
           I     L GH++  + ++  D  +VS + D T+K+W+  T + ++TL G   H+  + CL
Sbjct: 494 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 550

Query: 437 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 485
           Q+    V++ S D T++LWD++ G  +R L      G   +V  IR  N ++V      +
Sbjct: 551 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 610

Query: 486 GAYDGKIKVWD 496
           G  + K+ V D
Sbjct: 611 GTEETKLLVLD 621



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)

Query: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 311
           LQ +   ++    V CLQ++   +++   D T+K+WD  T E  R L    +G +G V+
Sbjct: 534 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 592


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  144 bits (364), Expect = 2e-34
 Identities = 87/290 (30%), Positives = 149/290 (51%), Gaps = 27/290 (9%)

Query: 270 VYCLQYDD---QKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGS 324
           VY + +++    KI +G  D T K+W   T +C     GHT  ++CL ++ +  ++ TGS
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196

Query: 325 SDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITL 382
            D+T ++WD+  GE + TL  H   ++ L FN     ++T S D ++ VWD  +   +  
Sbjct: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254

Query: 383 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQY 438
             +L+GH A ++   F  D   I++ S D+T K+W+ +  + V TL GH   I  +C  Y
Sbjct: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313

Query: 439 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 496
             +L+ + S+D T R++      C+  LEGHE  +  I F+     +++G+ D   ++WD
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373

Query: 497 LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIW 544
                   A  G  CL+ L  H+  +F   F+     +++ S D+T  IW
Sbjct: 374 --------AQTGQ-CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 64/205 (31%), Positives = 98/205 (47%), Gaps = 21/205 (10%)

Query: 353 LRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY---IVSASGD 409
           L  +    +T S DR+  +WD AS  ++     L GHR  V  + F++ Y   I + S D
Sbjct: 100 LNKSGSCFITGSYDRTCKLWDTASGEEL---NTLEGHRNVVYAIAFNNPYGDKIATGSFD 156

Query: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLE 467
           +T K+W+  T +   T  GH   I CL +  +  LV +GS D T +LWDI+ G  +  L 
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216

Query: 468 GHEELVRCIRFDNK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 525
           GH   +  + F+    RI++G++D  + VWD        A  G   +  L+ H   +   
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWD--------ADTGRK-VNILIGHCAEISSA 267

Query: 526 QF--DEFQIVSSSHDDTILIWDFLN 548
            F  D   I++ S D T  +WD  N
Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATN 292



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 73/236 (30%), Positives = 111/236 (47%), Gaps = 25/236 (10%)

Query: 321 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN---GMMVTCSKDRSIAVWDMASP 377
           ITGS D T ++WD  +GE LNTL  H   V  + FNN     + T S D++  +W + + 
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167

Query: 378 TDITLRRVLVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIAC 435
                 R   GH A +  + F+ +  + A+G  D T K+W+    E V TL GH   I  
Sbjct: 168 KCYHTFR---GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIIS 224

Query: 436 LQYR---DRLVVSGSSDNTIRLWDIECGACLRVLEGH--EELVRCIRFDNKRIVSGAYDG 490
           L +    DR +++GS D+T+ +WD + G  + +L GH  E       +D   I++G+ D 
Sbjct: 225 LSFNTSGDR-IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283

Query: 491 KIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIW 544
             K+WD              C+ TL  H   +    FD     I ++S D T  I+
Sbjct: 284 TCKLWD---------ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF 330


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  129 bits (324), Expect = 7e-30
 Identities = 87/298 (29%), Positives = 144/298 (48%), Gaps = 44/298 (14%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTG 337
           +VS   D TIK+WD  T + +R L GHT SV  + +D   +++ + S+D T+++WD    
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182

Query: 338 EMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
           E + T+  H   V  +    N   +V+ S+D++I +W++ +   +   +   GHR  V +
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239

Query: 396 V--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR------------ 441
           V  + D   I S S D+T++VW  +T E    L  H+  + C+ +               
Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299

Query: 442 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 489
                      ++SGS D TI++WD+  G CL  L GH+  VR + F +  K I+S A D
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359

Query: 490 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWD 545
             ++VWD              C++TL  H   V  L F +    +V+ S D T+ +W+
Sbjct: 360 KTLRVWDY---------KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408



 Score =  115 bits (288), Expect = 1e-25
 Identities = 83/281 (29%), Positives = 135/281 (48%), Gaps = 44/281 (15%)

Query: 300 KRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN 357
           K  L+GH   V  + +     V+++ S D+T++VWD  TG+   TL  H ++V  + F++
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160

Query: 358 G--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 413
              ++ +CS D +I +WD      I   R + GH   V+ V    +  +IVSAS D+TIK
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217

Query: 414 VWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEE 471
           +W   T   V+T  GH+  +  ++      L+ S S+D T+R+W +    C   L  HE 
Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277

Query: 472 LVRCIRF---------------DNKR-------IVSGAYDGKIKVWDLVAALDPRAPAGT 509
           +V CI +               + K+       ++SG+ D  IK+WD+            
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG--------- 328

Query: 510 LCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWDFLN 548
           +CL TLV H   V  + F      I+S + D T+ +WD+ N
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 29/166 (17%)

Query: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER----------------- 318
           D   I S   D T+++W   T ECK  L  H   V C+ +                    
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304

Query: 319 -----VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAV 371
                 +++GS D T+++WDV+TG  L TL+ H   V  + F++G   +++C+ D+++ V
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364

Query: 372 WDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 415
           WD  +       + L  H   V  +DF     Y+V+ S D+T+KVW
Sbjct: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407


>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
          Length = 670

 Score =  126 bits (316), Expect = 6e-29
 Identities = 79/278 (28%), Positives = 135/278 (48%), Gaps = 17/278 (6%)

Query: 272 CLQYDDQKIVSGLRDNTIKIWDK-NTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVR 330
           C+      + SG  D TIK+WD   T +C++ L GH G VL L      + +GS+D T+ 
Sbjct: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462

Query: 331 VWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 390
           VWD+   + +NT+  H   V  L  ++ ++ + S  ++I VWD+   T++ L++ L G  
Sbjct: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVG-TELKLKKELTGLN 520

Query: 391 AAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 450
             V  +     Y+ S S  +TIK+W+  T + +  L      +  +   +  +V G+ +N
Sbjct: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579

Query: 451 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAP 506
            I +WDIE    +R L GH   V  +      D  ++ S +YD  ++VW +         
Sbjct: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM--------- 630

Query: 507 AGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 544
              +C +TL+ H G V  L     ++ S + D T+ +W
Sbjct: 631 DNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 4/121 (3%)

Query: 256 SLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY 315
           +L  IH    +   VY +   +  IV G  +N I +WD  + E  R LTGH G+V  L  
Sbjct: 548 TLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAV 607

Query: 316 ----DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAV 371
               D+  + + S D ++RVW ++      TL+ H  +V  L  + G + + + D ++ V
Sbjct: 608 ISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKV 667

Query: 372 W 372
           W
Sbjct: 668 W 668



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 10/89 (11%)

Query: 462 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHS 519
           C     GH+  V   C+      + SG+ D  IKVWD              C +TL  H 
Sbjct: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439

Query: 520 GRVFRLQFDEFQIVSSSHDDTILIWDFLN 548
           G V  L     ++ S S D TI++WD  N
Sbjct: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQN 468


>gi|157266266 WD repeat domain 86 [Homo sapiens]
          Length = 376

 Score =  122 bits (307), Expect = 7e-28
 Identities = 98/344 (28%), Positives = 143/344 (41%), Gaps = 54/344 (15%)

Query: 273 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVW 332
           L  D Q++++G  D T ++W     +C  +L GH   V   Q ++    T S+D T+R W
Sbjct: 23  LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82

Query: 333 DVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 392
           DV TG+ L     H   V  +   N  + + S DR+  VW +       + R   GHR  
Sbjct: 83  DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139

Query: 393 VNVVDFDDKY----------------IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC- 435
           V  + +   +                +V+ S D T KVW  ++    +TL GH   + C 
Sbjct: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199

Query: 436 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 494
            L        +GS+D TIR WDI  G  LRV   H   V C+   N+ + SG+ D  +K 
Sbjct: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259

Query: 495 W---------------DLVAALDPRA-----PAGTLCLRTLVEHSG---RVFR------- 524
           W                 V+AL   A      +G  C R     SG   RVFR       
Sbjct: 260 WLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIIN 319

Query: 525 -LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPP--RSPSRTYT 565
            +Q     + ++SHD  + +WD      A   PP  RS SR ++
Sbjct: 320 CIQVHGQVLYTASHDGALRLWDVRGLRGAPRPPPPMRSLSRLFS 363



 Score =  108 bits (271), Expect = 1e-23
 Identities = 73/264 (27%), Positives = 114/264 (43%), Gaps = 32/264 (12%)

Query: 301 RILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG 358
           R+   H G +  L L  D + ++TGS D T R+W    G+    L  H   V   +  + 
Sbjct: 9   RVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE 68

Query: 359 MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTS 418
              TCS D +I  WD+ +   + + R   GH + VN +   +  + S+S DRT +VW+  
Sbjct: 69  AAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSVD 125

Query: 419 TCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGAC 462
             +  R   GH+  +  L Y                   L+V+GS+D T ++W +  G C
Sbjct: 126 KGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCC 185

Query: 463 LRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSG 520
            + L GH   V C+  D       +G+ D  I+ WD+++            LR   EH G
Sbjct: 186 HQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHRG 236

Query: 521 RVFRLQFDEFQIVSSSHDDTILIW 544
            V  L+     + S S D T+  W
Sbjct: 237 SVICLELVNRLVYSGSADRTVKCW 260



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 32/105 (30%), Positives = 55/105 (52%)

Query: 270 VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTV 329
           V CL+  ++ + SG  D T+K W  +T EC R  T H  +V  L+Y    + TGS D+  
Sbjct: 238 VICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACA 297

Query: 330 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDM 374
           R +D  +GE+      H   +  ++ +  ++ T S D ++ +WD+
Sbjct: 298 RAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/67 (31%), Positives = 36/67 (53%)

Query: 268 KGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDS 327
           + V  L+Y    + +G  D   + +D  + E +R+  GHT  + C+Q   +V+ T S D 
Sbjct: 276 RNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDG 335

Query: 328 TVRVWDV 334
            +R+WDV
Sbjct: 336 ALRLWDV 342


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  122 bits (306), Expect = 9e-28
 Identities = 77/237 (32%), Positives = 130/237 (54%), Gaps = 21/237 (8%)

Query: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWD 333
           D   +VS   D T+KIWD ++ +C + L GH+  V C  ++ +  +I++GS D +VR+WD
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157

Query: 334 VNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 391
           V TG+ L TL  H + V  + FN    ++V+ S D    +WD AS     L+ ++     
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215

Query: 392 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 444
            V+ V F  + KYI++A+ D T+K+W+ S  + ++T  GHK    C+         + +V
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275

Query: 445 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 495
           SGS DN + +W+++    ++ L+GH ++V    C   +N  I++ A    D  IK+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330



 Score =  111 bits (278), Expect = 2e-24
 Identities = 63/172 (36%), Positives = 97/172 (56%), Gaps = 17/172 (9%)

Query: 382 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 439
           L+  L GH  AV+ V F  + +++ S+S D+ IK+W     +F +T++GHK GI+ + + 
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 440 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 495
               L+VS S D T+++WD+  G CL+ L+GH   V C  F+  +  IVSG++D  +++W
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 496 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
           D+             CL+TL  HS  V  + F  D   IVSSS+D    IWD
Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score =  106 bits (264), Expect = 7e-23
 Identities = 67/233 (28%), Positives = 125/233 (53%), Gaps = 19/233 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 337
           + S   D  IKIW     + ++ ++GH   +  + +  D  ++++ S D T+++WDV++G
Sbjct: 60  LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119

Query: 338 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
           + L TL  H   V    FN  + ++V+ S D S+ +WD+ +   +   + L  H   V+ 
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPVSA 176

Query: 396 VDF--DDKYIVSASGDRTIKVWNTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSSDN 450
           V F  D   IVS+S D   ++W+T++ + ++TL +     ++ +++    + +++ + DN
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236

Query: 451 TIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDL 497
           T++LWD   G CL+   GH+    CI F N      K IVSG+ D  + +W+L
Sbjct: 237 TLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNL 288



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 39/151 (25%), Positives = 71/151 (47%), Gaps = 15/151 (9%)

Query: 425 TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 480
           TL GH + ++ +++      + S S+D  I++W    G   + + GH+  +  + +  D+
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 481 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHD 538
             +VS + D  +K+WD+ +           CL+TL  HS  VF   F+     IVS S D
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK---------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150

Query: 539 DTILIWDFLNDPAAQAEPPRSPSRTYTYISR 569
           +++ IWD       +  P  S   +  + +R
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  122 bits (306), Expect = 9e-28
 Identities = 77/237 (32%), Positives = 130/237 (54%), Gaps = 21/237 (8%)

Query: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWD 333
           D   +VS   D T+KIWD ++ +C + L GH+  V C  ++ +  +I++GS D +VR+WD
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157

Query: 334 VNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 391
           V TG+ L TL  H + V  + FN    ++V+ S D    +WD AS     L+ ++     
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215

Query: 392 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 444
            V+ V F  + KYI++A+ D T+K+W+ S  + ++T  GHK    C+         + +V
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275

Query: 445 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 495
           SGS DN + +W+++    ++ L+GH ++V    C   +N  I++ A    D  IK+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330



 Score =  111 bits (278), Expect = 2e-24
 Identities = 63/172 (36%), Positives = 97/172 (56%), Gaps = 17/172 (9%)

Query: 382 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 439
           L+  L GH  AV+ V F  + +++ S+S D+ IK+W     +F +T++GHK GI+ + + 
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 440 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 495
               L+VS S D T+++WD+  G CL+ L+GH   V C  F+  +  IVSG++D  +++W
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 496 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
           D+             CL+TL  HS  V  + F  D   IVSSS+D    IWD
Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199



 Score =  106 bits (264), Expect = 7e-23
 Identities = 67/233 (28%), Positives = 125/233 (53%), Gaps = 19/233 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 337
           + S   D  IKIW     + ++ ++GH   +  + +  D  ++++ S D T+++WDV++G
Sbjct: 60  LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119

Query: 338 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
           + L TL  H   V    FN  + ++V+ S D S+ +WD+ +   +   + L  H   V+ 
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPVSA 176

Query: 396 VDF--DDKYIVSASGDRTIKVWNTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSSDN 450
           V F  D   IVS+S D   ++W+T++ + ++TL +     ++ +++    + +++ + DN
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236

Query: 451 TIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDL 497
           T++LWD   G CL+   GH+    CI F N      K IVSG+ D  + +W+L
Sbjct: 237 TLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNL 288



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 39/151 (25%), Positives = 71/151 (47%), Gaps = 15/151 (9%)

Query: 425 TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 480
           TL GH + ++ +++      + S S+D  I++W    G   + + GH+  +  + +  D+
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 481 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHD 538
             +VS + D  +K+WD+ +           CL+TL  HS  VF   F+     IVS S D
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK---------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150

Query: 539 DTILIWDFLNDPAAQAEPPRSPSRTYTYISR 569
           +++ IWD       +  P  S   +  + +R
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  121 bits (303), Expect = 2e-27
 Identities = 77/236 (32%), Positives = 127/236 (53%), Gaps = 19/236 (8%)

Query: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWD 333
           D  ++VS   D T+K+WD  + +C + L GH+  V C  ++    +II+GS D TV++W+
Sbjct: 94  DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153

Query: 334 VNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 391
           V TG+ L TL  H + V  + FN    ++V+ S D    +WD AS     L+ ++     
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211

Query: 392 AVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 444
            V+ V F  + KYI++A+ D T+K+W+ S    ++T  GHK    C+         + +V
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271

Query: 445 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 495
           SGS DN + +W+++    ++ L+GH ++V    C   +N  I S A   D  IK+W
Sbjct: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 59/172 (34%), Positives = 92/172 (53%), Gaps = 17/172 (9%)

Query: 382 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 439
           L+  LVGH  AV+ V F  + +++ S+S DR I +W     ++ +TL GH   I+ + + 
Sbjct: 33  LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92

Query: 440 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 495
                +VS S D T++LWD+  G CL+ L+GH   V C  F+  +  I+SG++D  +K+W
Sbjct: 93  SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152

Query: 496 DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD--EFQIVSSSHDDTILIWD 545
           ++             CL+TL  HS  V  + F+     IVS S+D    IWD
Sbjct: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 62/233 (26%), Positives = 119/233 (51%), Gaps = 19/233 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 337
           + S   D  I IW     + ++ L GH   +  + +  D   +++ S D T+++WDV +G
Sbjct: 56  LASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115

Query: 338 EMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
           + L TL  H   V    FN  + ++++ S D ++ +W++ +   +   + L  H   V+ 
Sbjct: 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL---KTLSAHSDPVSA 172

Query: 396 VDFD--DKYIVSASGDRTIKVWNTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSSDN 450
           V F+     IVS S D   ++W+ ++ + ++TL +     ++ +++    + +++ + DN
Sbjct: 173 VHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDN 232

Query: 451 TIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDL 497
           T++LWD   G CL+   GH+    CI F N      K IVSG+ D  + +W+L
Sbjct: 233 TLKLWDYSRGRCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNL 284


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score =  111 bits (278), Expect = 2e-24
 Identities = 83/321 (25%), Positives = 151/321 (47%), Gaps = 41/321 (12%)

Query: 264 SETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VII 321
           SE    V  L  +D  +V       +K+++  T  C+ IL GHT  VL L    +  +  
Sbjct: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGWLFA 392

Query: 322 TGSSDSTVRVWDVNTGEMLNTLI------HHCEAVLHLRFNNGMMVTCSKDRSIAVWDMA 375
           + + D +VR+W +N    +  +       H    V   R     +VT S+D ++ +W + 
Sbjct: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452

Query: 376 S------------PTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCE 421
                        P  +  +     H   +N V    +DK + + S DRT K+W    C+
Sbjct: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512

Query: 422 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 479
            +   +GH+RG+ C+Q+   D+++ + S+D TI+LW ++  +CL+  EGH+  V  + F 
Sbjct: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572

Query: 480 NK--RIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL---QFDEFQIVS 534
           ++  +++S   DG +K+W +             C+RTL  H  +V+ L   + D+  +  
Sbjct: 573 SRGTQLLSSGSDGLVKLWTI---------KNNECVRTLDAHEDKVWGLHCSRLDDHALTG 623

Query: 535 SSHDDTILIWDFLNDPAAQAE 555
           +S D  +++W  + + A QAE
Sbjct: 624 AS-DSRVILWKDVTE-AEQAE 642



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 49/241 (20%), Positives = 100/241 (41%), Gaps = 23/241 (9%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYD----ERVIITGSSDSTVRVWDVN 335
           + +G  D  +++WD           G  G V  + +       ++ + ++D+ +RVW + 
Sbjct: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183

Query: 336 TGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAV 393
               L  L  H  AV  L F  +   M++  +D+   +WD+ S        V     AAV
Sbjct: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243

Query: 394 NV---------VDFDDKYIVSASGDRTIKVWNTSTCEFVRTL-----NGHKRGIACLQYR 439
            +         V     Y ++A    T++VW  ++ + V T       G +     L + 
Sbjct: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303

Query: 440 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 496
             +V++ ++D+ + L++       +   G+ E V  +RF   ++  +V  +    +KV++
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363

Query: 497 L 497
           L
Sbjct: 364 L 364



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 13/180 (7%)

Query: 329 VRVWDVNTGEMLNTLIHHCE---AVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRV 385
           V + +V +G +L +L    +       L  +N ++VT S+   +A W     +   L + 
Sbjct: 47  VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106

Query: 386 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-- 441
           +  H A V  + FD    + A+G  D  ++VW+           G    +  + +     
Sbjct: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164

Query: 442 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 497
             L+ S ++D  IR+W ++  +CL VL  H   V  + F  D   ++S   D    +WDL
Sbjct: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 49/216 (22%), Positives = 91/216 (42%), Gaps = 32/216 (14%)

Query: 273 LQYDDQKIVSGLRDNTIKIWDKNTLECKRILTG-HTGSVLCLQYD--ERVIITGSSDSTV 329
           L  D++ +V+  R   +  W        R+    HT  V  + +D    ++ TG  D  V
Sbjct: 74  LSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAV 133

Query: 330 RVWDVNTGEMLNTLIHH---CEAVLHL-RFNNG----MMVTCSKDRSIAVWDMASPTDIT 381
           RVWD+    + +   HH      V+HL  F+      ++ + + D +I VW +    D +
Sbjct: 134 RVWDI----VRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL---QDRS 186

Query: 382 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR 439
              VL  H +AV  + F  D   ++S+  D+   +W+  +C+  RT+   +   A +   
Sbjct: 187 CLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLP 246

Query: 440 DRLV------------VSGSSDNTIRLWDIECGACL 463
           +  V            ++     T+R+W+   G C+
Sbjct: 247 EEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCV 282


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  110 bits (276), Expect = 3e-24
 Identities = 74/267 (27%), Positives = 129/267 (48%), Gaps = 53/267 (19%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY-DERVIITGSSDSTVRVWDVNTGE 338
           + S  +D +++IWD     C+RILTGHT SV CL++  + ++ + S D T++VW  + G 
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278

Query: 339 MLNTLIHH----------------------CEAVLHLRFNNG------------------ 358
           +  TL  H                       EA ++ +   G                  
Sbjct: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338

Query: 359 ----MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 412
                +V+ S D ++ +W  A       R  + GH+A +N V F  D + + SAS D++I
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396

Query: 413 KVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 470
           K+W+  T +++ +L GH   +  + +    RL+VSGSSD+T+++WD++       L GH 
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456

Query: 471 ELVRCIRF--DNKRIVSGAYDGKIKVW 495
           + V  + +  D +R+ SG  D  +++W
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 89/329 (27%), Positives = 143/329 (43%), Gaps = 72/329 (21%)

Query: 276 DDQKIVSGLRDNTIKIWDKNT-LECKRILTGHTGSVLCLQYDE-------RVIITGSSDS 327
           D +K+ SG ++  I +WD +T  +  R L GH+  +  L ++        R + + S D 
Sbjct: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226

Query: 328 TVRVWDVNTGEMLNTLIHHCEAVLHLRF-NNGMMVTCSKDRSIAVW-------------- 372
           +VR+WD   G     L  H ++V  LR+  +G++ + S+DR+I VW              
Sbjct: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGH 286

Query: 373 -----DMASPTDITLRR-VLVGHRAAVNVVDFD---------------------DKYIVS 405
                 MA  TD  LR        A+VN  D                        + +VS
Sbjct: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS 346

Query: 406 ASGDRTIKVWNTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGAC 462
            S D T+ +W+ +  +   T + GH+  I  + +    R+V S S D +I+LWD   G  
Sbjct: 347 GSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 406

Query: 463 LRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA---ALDPRAPAGTLCLRTLVE 517
           L  L GH   V  I +  D++ +VSG+ D  +KVWD+ A   A+D            L  
Sbjct: 407 LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------LPG 454

Query: 518 HSGRVFRLQF--DEFQIVSSSHDDTILIW 544
           H+  V+ + +  D  ++ S   D  + IW
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 86/326 (26%), Positives = 136/326 (41%), Gaps = 72/326 (22%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 337
           + SG  D T++ WD +T        GH   VL + +  D R + +G  +  + +WD +TG
Sbjct: 129 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTG 188

Query: 338 EML-NTLIHHCEAV-------LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 389
           + +  TL  H + +       LH       + + SKD S+ +WD    T     R+L GH
Sbjct: 189 KQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD---TTAGRCERILTGH 245

Query: 390 RAAVNVVDF-DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACL------------ 436
             +V  + +  D  + SAS DRTIKVW        RTL GH   +  +            
Sbjct: 246 TQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGA 305

Query: 437 ------------------QYRDRL--------------VVSGSSDNTIRLWD-IECGACL 463
                             + ++R               +VSGS D T+ LW   E    L
Sbjct: 306 FEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPL 365

Query: 464 RVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGR 521
             + GH+ L+  + F  D++ + S ++D  IK+WD           G   L +L  H   
Sbjct: 366 TRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--------GRTGKY-LASLRGHVAA 416

Query: 522 VFRLQF--DEFQIVSSSHDDTILIWD 545
           V+++ +  D   +VS S D T+ +WD
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWD 442



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 72/272 (26%), Positives = 131/272 (48%), Gaps = 27/272 (9%)

Query: 299 CKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF- 355
           C   L GH+ +V+ + +    + + +GS D+TVR WD++T     T   H   VL + + 
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165

Query: 356 -NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 407
            +   + +  K+  I +WD +  T   + R L GH   +  + ++        +Y+ S+S
Sbjct: 166 PDGRKLASGCKNGQILLWDPS--TGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSS 223

Query: 408 GDRTIKVWNTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 466
            D ++++W+T+     R L GH + + CL++  D L+ S S D TI++W    G   R L
Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283

Query: 467 EGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLC-LRTLVEHSGRVFR 524
           +GH   V  +    +  + +GA++         A+++P+   G+L  L+        + R
Sbjct: 284 QGHGHWVNTMALSTDYALRTGAFE------PAEASVNPQDLQGSLQELKERALSRYNLVR 337

Query: 525 LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEP 556
            Q  E ++VS S D T+ +W     PA   +P
Sbjct: 338 GQGPE-RLVSGSDDFTLFLW----SPAEDKKP 364


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  109 bits (272), Expect = 8e-24
 Identities = 71/249 (28%), Positives = 115/249 (46%), Gaps = 18/249 (7%)

Query: 250 WRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGS 309
           WR G H+     CR            D     S   D T+++WD    +C R+L GH  S
Sbjct: 57  WRLGGHTGPVKFCRFSP---------DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS 107

Query: 310 VLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN--GMMVTCSK 365
           V  + +  D R + +G  D  V +WDV +G+ML  L+ H +++    F+     + T S 
Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167

Query: 366 DRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFD-DKYIVSASGDRTIKVWNTSTCEFVR 424
           D ++ +WD+   T     + L GH A ++ + +     + S S D+TI +W  +T   + 
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLI 227

Query: 425 TLNGHKRGIACLQYR-DRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 480
            L GH   +  + +  D L + S      +++WD   G CL  L+G  ++     F  D 
Sbjct: 228 QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDG 287

Query: 481 KRIVSGAYD 489
           K +VSGA D
Sbjct: 288 KILVSGAAD 296



 Score =  100 bits (250), Expect = 3e-21
 Identities = 70/233 (30%), Positives = 112/233 (48%), Gaps = 15/233 (6%)

Query: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 333
           D Q +++G  D  +  W+  + +    L GHTG V   ++  D  +  + S D TVR+WD
Sbjct: 32  DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91

Query: 334 VNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRA 391
           V   + L  L  H  +V  + F  ++  + +   D+ + +WD+ S     + R+LVGHR 
Sbjct: 92  VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG---QMLRLLVGHRD 148

Query: 392 AVNVVDFDD--KYIVSASGDRTIKVWN---TSTCEFVRTLNGHKRGIACLQY-RDRLVVS 445
           ++   DF      + + S D T+ +W+    +     + L GH   I+CL Y    L+ S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208

Query: 446 GSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
           GS D TI +W     + L  L+GH   V+ I F  D   + S  Y   +KVWD
Sbjct: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 63/242 (26%), Positives = 115/242 (47%), Gaps = 24/242 (9%)

Query: 316 DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWD 373
           D ++++TGS D  V  W+  +G++L  L  H   V   RF  +  +  + S D ++ +WD
Sbjct: 32  DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91

Query: 374 MASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKR 431
           +A    +   RVL GH+ +V  V F  D + + S   D+ + +W+  + + +R L GH+ 
Sbjct: 92  VARAKCL---RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD 148

Query: 432 GIACLQYRDRL--VVSGSSDNTIRLWDIEC---GACLRVLEGHEELVRCIRFD-NKRIVS 485
            I    +   +  + +GS D+T+ +WD+         + LEGH   + C+ +  +  + S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208

Query: 486 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILI 543
           G++D  I +W          P  +  L  L  H   V  + F  DE  + S+ +   + +
Sbjct: 209 GSWDKTIHIW---------KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259

Query: 544 WD 545
           WD
Sbjct: 260 WD 261



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 52/179 (29%), Positives = 84/179 (46%), Gaps = 19/179 (10%)

Query: 377 PTDITLRRVLV--GHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRG 432
           P  + +RRV     H   VN   F  D + +++ S D  +  W T + + +  L GH   
Sbjct: 6   PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGP 65

Query: 433 IACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAY 488
           +   ++     L  S S D T+RLWD+    CLRVL+GH+  V  + F  D++++ SG +
Sbjct: 66  VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125

Query: 489 DGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWD 545
           D ++ +WD+ +            LR LV H   +    F      + + S D T+ IWD
Sbjct: 126 DKRVMLWDVQSG---------QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  106 bits (264), Expect = 7e-23
 Identities = 72/251 (28%), Positives = 122/251 (48%), Gaps = 14/251 (5%)

Query: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQ 314
           LQ I   +     +   +   + + +G  D  + +W  N   C   LTGHT  V  + L 
Sbjct: 13  LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72

Query: 315 YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVW 372
             E +I+ GS   ++RVWD+   ++L TL+ H   +  L F+     + + S+D +I +W
Sbjct: 73  TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132

Query: 373 DMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 430
           D+     +   R   GH  AV  + F  D K++ SA+ D T+K+W+ +  + +    GH 
Sbjct: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189

Query: 431 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 486
             +  +++   + L+ SGSSD TIR WD+E    +  +EG    VR + F  D   + SG
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249

Query: 487 AYDG-KIKVWD 496
             D  ++  W+
Sbjct: 250 CQDSLRVYGWE 260



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 69/221 (31%), Positives = 103/221 (46%), Gaps = 23/221 (10%)

Query: 336 TGEMLNTLIHHCEAVLHL---RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 392
           T   L  ++ H   V  L   + +  ++ T   D  + +W +  P  I     L GH + 
Sbjct: 9   TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSP 65

Query: 393 VNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSS 448
           V  V  +  ++ IV+ S   +I+VW+    + +RTL GHK  I  L +      V SGS 
Sbjct: 66  VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125

Query: 449 DNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAP 506
           D  I+LWDI    C+    GH + VRC+RF  D K + S A D  +K+WDL A       
Sbjct: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG------ 179

Query: 507 AGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
                +     H+G V  ++F  +E+ + S S D TI  WD
Sbjct: 180 ---KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217


>gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens]
          Length = 454

 Score =  103 bits (257), Expect = 4e-22
 Identities = 114/463 (24%), Positives = 184/463 (39%), Gaps = 120/463 (25%)

Query: 103 KYFEQWSESDQVEFV-----------EHLISQMCHYQHGHINSYLKPMLQRDFITALPAR 151
           K FE W ++  V F+           +HLIS     Q  H+++ L+ +L+RDF+  LP  
Sbjct: 4   KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63

Query: 152 GLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRG 211
               ++  +L +LD ++L    LV K+W +V S                 +W+   +  G
Sbjct: 64  ----LSFYLLKWLDPQTLLTCCLVSKQWNKVIS-------------ACTEVWQTACKNLG 106

Query: 212 WGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVY 271
           W          D +      ++ +Y K I  ++ +E             H   ETS    
Sbjct: 107 W--------QIDDSVQDALHWKKVYLKAILRMKQLED------------HEAFETSS--- 143

Query: 272 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRV 331
                                          L GH+  V  L Y + ++ TGS D + ++
Sbjct: 144 -------------------------------LIGHSARVYALYYKDGLLCTGSDDLSAKL 172

Query: 332 WDVNTGEMLNTL-IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 390
           WDV+TG+ +  +  H C AV   +F+   +VT S D ++A W+ +S       R   GH 
Sbjct: 173 WDVSTGQCVYGIQTHTCAAV---KFDEQKLVTGSFDNTVACWEWSSGARTQHFR---GHT 226

Query: 391 AAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI-----------ACLQ 437
            AV  VD++D+   +VS S D T+KVW  S    + TL GH   +           + L 
Sbjct: 227 GAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLH 286

Query: 438 YRDRLVVSGSSDNTIRLW----DIECGACLRVLEGHEELVRCIR----FDNKRIVS---- 485
                ++  +    I++W    +I C  CL+ L   E+   C++    FD K IV     
Sbjct: 287 SPGDYILLSADKYEIKIWPIGREINC-KCLKTLSVSEDRSICLQPRLHFDGKYIVCSSAL 345

Query: 486 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD 528
           G Y      +D++  +     A    L       G +F L FD
Sbjct: 346 GLYQWDFASYDILRVIKTPEIANLALL-----GFGDIFALLFD 383



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 36/122 (29%), Positives = 64/122 (52%), Gaps = 13/122 (10%)

Query: 425 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 484
           +L GH   +  L Y+D L+ +GS D + +LWD+  G C+  ++ H      ++FD +++V
Sbjct: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200

Query: 485 SGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF-DEFQI-VSSSHDDTIL 542
           +G++D  +  W+  +    +   G         H+G VF + + DE  I VS S D T+ 
Sbjct: 201 TGSFDNTVACWEWSSGARTQHFRG---------HTGAVFSVDYNDELDILVSGSADFTVK 251

Query: 543 IW 544
           +W
Sbjct: 252 VW 253



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 11/88 (12%)

Query: 466 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRL 525
           L GH   V  + + +  + +G+ D   K+WD+             C+  +  H+     +
Sbjct: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192

Query: 526 QFDEFQIVSSSHDDTILIWDFLNDPAAQ 553
           +FDE ++V+ S D+T+  W++ +    Q
Sbjct: 193 KFDEQKLVTGSFDNTVACWEWSSGARTQ 220


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  102 bits (255), Expect = 7e-22
 Identities = 71/242 (29%), Positives = 115/242 (47%), Gaps = 18/242 (7%)

Query: 274 QYDDQKIVSGLRDNTI-KIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVR 330
           Q  D  ++    D+ + +I D+ T    +IL GH+G V    +  D   +++ S D TVR
Sbjct: 509 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVR 568

Query: 331 VWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVW--DMASPTDITLRRVL 386
           +W + T   L     H   V   +F+      V+   DR   +W  D   P      R+ 
Sbjct: 569 LWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPL-----RIF 623

Query: 387 VGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQY--RDRL 442
            GH A VN   F  +  Y+ + S DRT+++W+      VR   GHK  I  L +    R 
Sbjct: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683

Query: 443 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAA 500
           + +G++D  + LWDI  G  +  L+GH + V  +RF  D + + SG+ D  +++WD + A
Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA 743

Query: 501 LD 502
            +
Sbjct: 744 FE 745



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 86/350 (24%), Positives = 149/350 (42%), Gaps = 45/350 (12%)

Query: 218 KNKPPDGNAPPNSFYRALYPKI--------IQDIETIESNWRCGRHSLQRI--HCRSETS 267
           K+K  D NAPP +  R   P++        I +++      R G   L  I  +      
Sbjct: 413 KSKKQDPNAPPQN--RIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAY 470

Query: 268 KGVYCLQYDDQK--IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSS 325
           +G+  +   D    I  G  D+T+++W     + + +             D  +I   S 
Sbjct: 471 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQAS---------DLSLIDKESD 521

Query: 326 DSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLR 383
           D   R+ D  T   L  L  H   V    F+     +++ S+D ++ +W + + T +   
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581

Query: 384 RVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR-- 439
           +   GH   V    F     Y VS   DR  ++W T   + +R   GH   + C ++   
Sbjct: 582 K---GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638

Query: 440 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 497
              V +GS+D T+RLWD+  G C+R+  GH+  +  + F  + + + +GA DG++ +WD+
Sbjct: 639 SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698

Query: 498 VAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
                       L +  L  H+  V  L+F  D   + S S D+T+ +WD
Sbjct: 699 ---------GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score =  101 bits (251), Expect = 2e-21
 Identities = 79/279 (28%), Positives = 134/279 (48%), Gaps = 16/279 (5%)

Query: 277 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDV 334
           +Q  V+G  D TIKIWD  + + K  LTGH  +V  +    R   + +   D  V+ WD+
Sbjct: 216 NQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275

Query: 335 NTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 392
              +++     H  AV  L L     ++VTCS+D +  +WD+ +   +     L GH  A
Sbjct: 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNA 332

Query: 393 VNVV--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSS 448
           V  V     +  I++ S D TI++W+    +   TL  HK+ +    L  R     SGS 
Sbjct: 333 VATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSP 392

Query: 449 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLVAALDPRAPA 507
           DN I+ W    G+ ++ L GH  ++  +  ++  + VSGA +G + +WD     + +   
Sbjct: 393 DN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVH 451

Query: 508 GTLCLRTLVEHSGRVFRLQFD--EFQIVSSSHDDTILIW 544
             +   +L   SG +F   FD  E +++++  D TI ++
Sbjct: 452 AAVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489



 Score =  100 bits (248), Expect = 5e-21
 Identities = 71/257 (27%), Positives = 130/257 (50%), Gaps = 24/257 (9%)

Query: 301 RILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFN 356
           R+++GH G V C+  +   +  +TGS+D T+++WD+ +G++  +L  H   V  + +   
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257

Query: 357 NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 414
           +  + +C +D+ +  WD+     I   R   GH +AV  +D       +V+ S D T ++
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314

Query: 415 WNTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 472
           W+  T   V TL+GH   +A +  Q  +  +++GS D TIRLWD+  G     L  H++ 
Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374

Query: 473 VRCIRFDNKR--IVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD-E 529
           VR +    +     SG+ D  IK W        + P G+  ++ L  H+  +  L  + +
Sbjct: 375 VRAVVLHPRHYTFASGSPD-NIKQW--------KFPDGSF-IQNLSGHNAIINTLTVNSD 424

Query: 530 FQIVSSSHDDTILIWDF 546
             +VS + + T+ +WD+
Sbjct: 425 GVLVSGADNGTMHLWDW 441



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 19/175 (10%)

Query: 382 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGH---KRGIACL 436
           L RV+ GH   V  +  +  +++ V+ S DRTIK+W+ ++ +   +L GH    RG+  +
Sbjct: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254

Query: 437 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 494
             R   + S   D  ++ WD+E    +R   GH   V  +        +V+ + D   ++
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314

Query: 495 WDLVAALDPRAPAGTLCLRTLVEHSGRV--FRLQFDEFQIVSSSHDDTILIWDFL 547
           WD+      R  A    + TL  H+  V   R Q  E QI++ SHD TI +WD +
Sbjct: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 26/194 (13%)

Query: 245 TIESNWRCGRHSLQRI---------HCRSETSKGVYCL--QYDDQKIVSGLRDNTIKIWD 293
           TI+    C R S  RI         H  S  +  V  +  Q  + +I++G  D TI++WD
Sbjct: 299 TIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358

Query: 294 KNTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVL 351
               + +  LT H  SV  +    R     +GS D+ ++ W    G  +  L  H   + 
Sbjct: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIIN 417

Query: 352 HLRFN-NGMMVTCSKDRSIAVWDMASPTDITLRRV-------LVGHRAAVNVVDFD--DK 401
            L  N +G++V+ + + ++ +WD    T    +RV        +   + +    FD  + 
Sbjct: 418 TLTVNSDGVLVSGADNGTMHLWDWR--TGYNFQRVHAAVQPGSLDSESGIFACAFDQSES 475

Query: 402 YIVSASGDRTIKVW 415
            +++A  D+TIKV+
Sbjct: 476 RLLTAEADKTIKVY 489


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 73/280 (26%), Positives = 120/280 (42%), Gaps = 30/280 (10%)

Query: 243 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQY--DDQKIVSGLRDNTIKIWDK 294
           I  +  N   G   L   HC  E      ++K V  L +  D   +  G  D   +IW +
Sbjct: 205 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE 264

Query: 295 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
           N       L  H G +  L+++++   +++   D T  +WD +TGE       H    L 
Sbjct: 265 NG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323

Query: 353 LRFNNGM-MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 409
           + + N M   +CS D  I V  +     +   +   GH   VN + +D     + S S D
Sbjct: 324 VDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 380

Query: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 458
            T+K+W+      V  L  H + I  +++              ++ S S D+T+RLWD+E
Sbjct: 381 MTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE 440

Query: 459 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
            G C   L  H+E V  + F  D K + SG++D  + +W+
Sbjct: 441 QGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 47/278 (16%)

Query: 302 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 347
           +L GH   V    ++    ++ +GS DST R+W++N    G     ++ HC         
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 348 --EAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 401
             + V  L +N+   ++   S D    +W      +  L   L  H+  +  + ++ K  
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289

Query: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 460
           Y++SA  D+T  +W+  T E  +    H      + +++ +   S S+D  I +  + C 
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349

Query: 461 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 518
             ++  +GH   V  I++D     + S + D  +K+W +             C+  L  H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM---------KQDACVHDLQAH 400

Query: 519 SGRVFRLQF-----------DEFQIVSSSHDDTILIWD 545
           S  ++ +++               + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 49/235 (20%), Positives = 99/235 (42%), Gaps = 20/235 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 338
           ++S   D T  IWD +T E K+    H+   L + +   +     S+D  + V  +    
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDH 350

Query: 339 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
            + T   H   V  ++++ +GM++ +CS D ++ +W M     +     L  H   +  +
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV---HDLQAHSKEIYTI 407

Query: 397 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 443
            +               + SAS D T+++W+        TL  H+  +  + +    + +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467

Query: 444 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 497
            SGS D  + +W+ + G+ +   +G   +   C      ++ + A DG + V DL
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 73/280 (26%), Positives = 120/280 (42%), Gaps = 30/280 (10%)

Query: 243 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQY--DDQKIVSGLRDNTIKIWDK 294
           I  +  N   G   L   HC  E      ++K V  L +  D   +  G  D   +IW +
Sbjct: 205 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE 264

Query: 295 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
           N       L  H G +  L+++++   +++   D T  +WD +TGE       H    L 
Sbjct: 265 NG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323

Query: 353 LRFNNGM-MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 409
           + + N M   +CS D  I V  +     +   +   GH   VN + +D     + S S D
Sbjct: 324 VDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 380

Query: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 458
            T+K+W+      V  L  H + I  +++              ++ S S D+T+RLWD+E
Sbjct: 381 MTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE 440

Query: 459 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
            G C   L  H+E V  + F  D K + SG++D  + +W+
Sbjct: 441 QGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 47/278 (16%)

Query: 302 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 347
           +L GH   V    ++    ++ +GS DST R+W++N    G     ++ HC         
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 348 --EAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 401
             + V  L +N+   ++   S D    +W      +  L   L  H+  +  + ++ K  
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289

Query: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 460
           Y++SA  D+T  +W+  T E  +    H      + +++ +   S S+D  I +  + C 
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349

Query: 461 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 518
             ++  +GH   V  I++D     + S + D  +K+W +             C+  L  H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM---------KQDACVHDLQAH 400

Query: 519 SGRVFRLQF-----------DEFQIVSSSHDDTILIWD 545
           S  ++ +++               + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 49/235 (20%), Positives = 99/235 (42%), Gaps = 20/235 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 338
           ++S   D T  IWD +T E K+    H+   L + +   +     S+D  + V  +    
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDH 350

Query: 339 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
            + T   H   V  ++++ +GM++ +CS D ++ +W M     +     L  H   +  +
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV---HDLQAHSKEIYTI 407

Query: 397 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 443
            +               + SAS D T+++W+        TL  H+  +  + +    + +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467

Query: 444 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 497
            SGS D  + +W+ + G+ +   +G   +   C      ++ + A DG + V DL
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 73/280 (26%), Positives = 120/280 (42%), Gaps = 30/280 (10%)

Query: 243 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQY--DDQKIVSGLRDNTIKIWDK 294
           I  +  N   G   L   HC  E      ++K V  L +  D   +  G  D   +IW +
Sbjct: 205 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTE 264

Query: 295 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
           N       L  H G +  L+++++   +++   D T  +WD +TGE       H    L 
Sbjct: 265 NG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323

Query: 353 LRFNNGM-MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 409
           + + N M   +CS D  I V  +     +   +   GH   VN + +D     + S S D
Sbjct: 324 VDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 380

Query: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 458
            T+K+W+      V  L  H + I  +++              ++ S S D+T+RLWD+E
Sbjct: 381 MTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE 440

Query: 459 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
            G C   L  H+E V  + F  D K + SG++D  + +W+
Sbjct: 441 QGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN 480



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 58/278 (20%), Positives = 115/278 (41%), Gaps = 47/278 (16%)

Query: 302 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 347
           +L GH   V    ++    ++ +GS DST R+W++N    G     ++ HC         
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233

Query: 348 --EAVLHLRFNNG--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 401
             + V  L +N+   ++   S D    +W      +  L   L  H+  +  + ++ K  
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289

Query: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 460
           Y++SA  D+T  +W+  T E  +    H      + +++ +   S S+D  I +  + C 
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349

Query: 461 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 518
             ++  +GH   V  I++D     + S + D  +K+W +             C+  L  H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM---------KQDACVHDLQAH 400

Query: 519 SGRVFRLQF-----------DEFQIVSSSHDDTILIWD 545
           S  ++ +++               + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 49/235 (20%), Positives = 99/235 (42%), Gaps = 20/235 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 338
           ++S   D T  IWD +T E K+    H+   L + +   +     S+D  + V  +    
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDH 350

Query: 339 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
            + T   H   V  ++++ +GM++ +CS D ++ +W M     +     L  H   +  +
Sbjct: 351 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACV---HDLQAHSKEIYTI 407

Query: 397 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 443
            +               + SAS D T+++W+        TL  H+  +  + +    + +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467

Query: 444 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 497
            SGS D  + +W+ + G+ +   +G   +   C      ++ + A DG + V DL
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 71/280 (25%), Positives = 124/280 (44%), Gaps = 30/280 (10%)

Query: 243 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQYDDQK--IVSGLRDNTIKIWDK 294
           I  +  N   G   L   HC  E      ++K V  L ++ +   + +G  D   +IW K
Sbjct: 195 IWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTK 254

Query: 295 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
           +       L  H G +  L+++++   I++   D T  +WD +TGE       H    L 
Sbjct: 255 DG-NLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 313

Query: 353 LRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGD 409
           + + +N    +CS D  I V  +     I   +   GH   VN + +D     + S S D
Sbjct: 314 VDWQSNNTFASCSTDMCIHVCKLGQDRPI---KTFQGHTNEVNAIKWDPTGNLLASCSDD 370

Query: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYR-----------DRLVVSGSSDNTIRLWDIE 458
            T+K+W+      V  L  H + I  +++            + ++ S S D+T+RLWD++
Sbjct: 371 MTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD 430

Query: 459 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
            G C+  L  H+E V  + F  D + + SG++D  + +W+
Sbjct: 431 RGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 64/320 (20%), Positives = 125/320 (39%), Gaps = 89/320 (27%)

Query: 302 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDV---NTGEMLNTLIHHC--------- 347
           +L GH   V    ++    ++ +GS DST R+W++   +T      ++ HC         
Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223

Query: 348 --EAVLHLRFNN--GMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 401
             + V  L +N+   ++ T S D    +W      D  L   L  H+  +  + ++ K  
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIW----TKDGNLASTLGQHKGPIFALKWNKKGN 279

Query: 402 YIVSASGDRTIKVWNTSTCEF--------------------------------------- 422
           +I+SA  D+T  +W+  T E                                        
Sbjct: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQD 339

Query: 423 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 478
             ++T  GH   +  +++     L+ S S D T+++W ++   C+  L+ H + +  I++
Sbjct: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399

Query: 479 D-----------NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 527
                       N  + S ++D  +++WD+            +C+ TL +H   V+ + F
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRG---------ICIHTLTKHQEPVYSVAF 450

Query: 528 --DEFQIVSSSHDDTILIWD 545
             D   + S S D  + IW+
Sbjct: 451 SPDGRYLASGSFDKCVHIWN 470



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 50/235 (21%), Positives = 97/235 (41%), Gaps = 20/235 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER-VIITGSSDSTVRVWDVNTGE 338
           I+S   D T  IWD +T E K+    H+   L + +       + S+D  + V  +    
Sbjct: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340

Query: 339 MLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
            + T   H   V  ++++    ++ +CS D ++ +W M     +     L  H   +  +
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCV---HDLQAHNKEIYTI 397

Query: 397 DFD-----------DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 443
            +            +  + SAS D T+++W+      + TL  H+  +  + +    R +
Sbjct: 398 KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYL 457

Query: 444 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 497
            SGS D  + +W+ + GA +    G   +   C      ++ + A DG + V DL
Sbjct: 458 ASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 38/155 (24%)

Query: 426 LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRF--- 478
           L GH+  +    +     L+ SGS D+T R+W++   +      G  +LV   CIR    
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENS----TSGSTQLVLRHCIREGGQ 220

Query: 479 ---DNKRIVS------------GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVF 523
               NK + S            G+YDG  ++W            G L   TL +H G +F
Sbjct: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIW---------TKDGNLA-STLGQHKGPIF 270

Query: 524 RLQFDEFQ--IVSSSHDDTILIWDFLNDPAAQAEP 556
            L++++    I+S+  D T +IWD     A Q  P
Sbjct: 271 ALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFP 305


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 70/293 (23%), Positives = 138/293 (47%), Gaps = 28/293 (9%)

Query: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 335
           D+  ++S   D+ IKIW+++TL+C R +T            +R ++ G+    ++++D+ 
Sbjct: 426 DNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484

Query: 336 TGEMLNTLIHHCEAVLHLRFNNGM--MVTCSKDRSIAVWD--MASPTDITLRRVLVGHRA 391
           +G +L T+  H  A+  +  +      VT   D+S+  WD  +    + T +R+ V    
Sbjct: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544

Query: 392 AVNVVDF--------DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDR 441
            + + +         + K +  +  D T+K++   T +F  +L GHK  + C+   +   
Sbjct: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604

Query: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLVA 499
           L+ +GS+D  +++W ++ G C + L  H++ V  ++F  K     +   D KIK WD   
Sbjct: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664

Query: 500 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWDFLNDP 550
                       ++TL  H   ++ L        +VSSSHD ++ +W+   +P
Sbjct: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREP 708



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 48/159 (30%), Positives = 86/159 (54%), Gaps = 11/159 (6%)

Query: 265 ETSKGVYCLQYD-DQKIVS-GLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ--YDERVI 320
           +  + V C+ Y  +QK+++  L D T+KI+  +TL+    L GH   V+C+   +D  +I
Sbjct: 547 QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI 606

Query: 321 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPT 378
            TGS+D  V++W ++ G+   +L  H ++V++L+F   + +  T  KD  I  WD     
Sbjct: 607 ATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE 666

Query: 379 DITLRRVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 415
            I   + L GH   +    V     Y+VS+S D+++++W
Sbjct: 667 HI---QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 16/190 (8%)

Query: 291 IWDKNTLECKRILTGHTGSVLCL--QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCE 348
           IWD    E   IL G    V CL    D   +  G  D ++R++ + +GE   T   H  
Sbjct: 49  IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108

Query: 349 AVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIV 404
           A+  L+++   G + + SKD  I VWD+ + + +     L GH+ A+    F  +   +V
Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165

Query: 405 SASGDRTIKVWNTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 461
           ++  D  +K W+  T    +T+ GH+    G+  L    RL ++G+SD+ +R+WDI   A
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221

Query: 462 CLRVLEGHEE 471
            L+ +E  EE
Sbjct: 222 YLQEIEDPEE 231



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 55/204 (26%), Positives = 96/204 (47%), Gaps = 24/204 (11%)

Query: 273 LQYDDQKIVSGLRDNTIKIW------DKNTLECKRILTGHTGS------VLCLQY--DER 318
           L  D +  V+G  D ++K W      D+N+ + KR+    T +      VLC+ Y  +++
Sbjct: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQ-KRLSVKQTRTLQLDEDVLCVSYSPNQK 562

Query: 319 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMAS 376
           ++     D TV+++ V+T +   +L  H   V  + +  +  ++ T S DR++ +W +  
Sbjct: 563 LLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDF 622

Query: 377 PTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 434
                  + L  H  +V  + F  K     +A  D  IK W+    E ++TL GH + I 
Sbjct: 623 G---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIW 679

Query: 435 CLQYRDR--LVVSGSSDNTIRLWD 456
           CL        VVS S D ++RLW+
Sbjct: 680 CLAVSPSGDYVVSSSHDKSLRLWE 703



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 49/178 (27%), Positives = 89/178 (50%), Gaps = 13/178 (7%)

Query: 329 VRVWDVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTCS-KDRSIAVWDMASPT-DITLRRV 385
           V +WD+  GE +  L    + V  L  + +G+ +    +D SI ++ + S   ++T    
Sbjct: 47  VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104

Query: 386 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA-CLQYRDR- 441
             GH+AA+  + +D     + S S D  I VW+      +  L GHK  I   L  R++ 
Sbjct: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162

Query: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDL 497
           L+V+   D  ++ WD++   C + + GH   V    +  + KR+++GA D +++VWD+
Sbjct: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 40/151 (26%), Positives = 72/151 (47%), Gaps = 9/151 (5%)

Query: 272 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTV 329
           C   D   +  G  D +I+I+   + E      GH  ++  L+YD+    + +GS D+ +
Sbjct: 72  CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131

Query: 330 RVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLV 387
            VWDV     L  L  H +A+    F     ++VT  KD  +  WD+ +       + +V
Sbjct: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188

Query: 388 GHRAAV--NVVDFDDKYIVSASGDRTIKVWN 416
           GHR  V   V+  ++K +++ + D  ++VW+
Sbjct: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVWD 219



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 23/57 (40%), Positives = 36/57 (63%), Gaps = 2/57 (3%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDV 334
           +V+  +D  +K WD +T  C + + GH   V  L L  +E+ +ITG+SDS +RVWD+
Sbjct: 164 LVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 4/89 (4%)

Query: 414 VWNTSTCEFVRTLNGHKRGIACL-QYRDRLVVS-GSSDNTIRLWDIECGACLRVLEGHEE 471
           +W+    E +  L G K+ + CL    D L ++ G  D +IR++ +  G       GH+ 
Sbjct: 49  IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108

Query: 472 LVRCIRFDNK--RIVSGAYDGKIKVWDLV 498
            +  +++D    R+ SG+ D  I VWD++
Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVI 137


>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
           [Homo sapiens]
          Length = 906

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 65/251 (25%), Positives = 122/251 (48%), Gaps = 16/251 (6%)

Query: 258 QRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE 317
           +++  RS+  K V  L   +  +++ L + ++ +W+  T    +        V   ++  
Sbjct: 9   RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67

Query: 318 RV--IITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWD 373
           R   ++TG+ D  +RV++ NT E ++    H + +  + +      ++T S D  I +WD
Sbjct: 68  RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127

Query: 374 MASPTDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 430
                  +  +V  GH   V  +     D+    SAS DRTIKVW   +     TL GH+
Sbjct: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185

Query: 431 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 484
           +G+ C+ Y        ++SG+ D  +++WD +   C++ LEGH + V C  F  +   I+
Sbjct: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245

Query: 485 SGAYDGKIKVW 495
           +G+ DG +++W
Sbjct: 246 TGSEDGTVRIW 256



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 48/194 (24%), Positives = 91/194 (46%), Gaps = 15/194 (7%)

Query: 255 HSLQRIHCRSETSKGVYCLQYDDQK--IVSGLRDNTIKIWD-KNTLECKRILTGHTGSVL 311
           ++L+R+H     S  + C+     +  I++   D  IK+WD      C ++  GHT  V+
Sbjct: 87  NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146

Query: 312 CLQY---DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG----MMVTCS 364
            +     D     + S D T++VW + +     TL  H + V  + + +G     +++ +
Sbjct: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206

Query: 365 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEF 422
            DR + +WD  + T +   + L GH   V+   F  +   I++ S D T+++W++ST   
Sbjct: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263

Query: 423 VRTLNGHKRGIACL 436
             TLN     + C+
Sbjct: 264 ESTLNYGMERVWCV 277



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 69/268 (25%), Positives = 113/268 (42%), Gaps = 36/268 (13%)

Query: 297 LECKRILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLR 354
           L+ KR LT  +  V  + L   E  ++    + +V VW+  T  ++ T       V   +
Sbjct: 5   LDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAK 64

Query: 355 F--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLV--GHRAAVNVVDFD--DKYIVSASG 408
           F      +VT + D  I V++       TL RV +   H   +  +       +I+++S 
Sbjct: 65  FVARKNWVVTGADDMQIRVFNYN-----TLERVHMFEAHSDYIRCIAVHPTQPFILTSSD 119

Query: 409 DRTIKVWNTS---TCEFVRTLNGHKRGIACLQYRDR---LVVSGSSDNTIRLWDIECGAC 462
           D  IK+W+     +C  V    GH   +  +    +      S S D TI++W +   + 
Sbjct: 120 DMLIKLWDWDKKWSCSQV--FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177

Query: 463 LRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEH 518
              LEGHE+ V CI +    D   ++SGA D  +K+WD              C++TL  H
Sbjct: 178 NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY---------QNKTCVQTLEGH 228

Query: 519 SGRVFRLQFDEFQ--IVSSSHDDTILIW 544
           +  V    F      I++ S D T+ IW
Sbjct: 229 AQNVSCASFHPELPIIITGSEDGTVRIW 256


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 72/280 (25%), Positives = 120/280 (42%), Gaps = 30/280 (10%)

Query: 243 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQYDDQK--IVSGLRDNTIKIWDK 294
           I  +  N   G   L   HC  E      ++K V  L ++     + +G  D   +IW +
Sbjct: 207 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE 266

Query: 295 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
           +       L  H G +  L+++ +   I++   D T  +WD +TGE       H    L 
Sbjct: 267 DG-NLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325

Query: 353 LRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 409
           + + NN    +CS D  I V  +     +   +   GH   VN + +D     + S S D
Sbjct: 326 VDWQNNTTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 382

Query: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 458
            T+K+W+      +  L  H + I  +++              ++ S S D+T+RLWDIE
Sbjct: 383 MTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442

Query: 459 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
            G C   L  H+E V  + F  D K + SG++D  + +W+
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 69/320 (21%), Positives = 125/320 (39%), Gaps = 89/320 (27%)

Query: 302 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 347
           +L GH   V    ++    ++ +GS DST R+W++N    G     ++ HC         
Sbjct: 176 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235

Query: 348 --EAVLHLRFN-NG-MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 401
             + V  L +N NG ++ T S D    +W      D  L   L  H+  +  + ++ K  
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW----TEDGNLASTLGQHKGPIFALKWNRKGN 291

Query: 402 YIVSASGDRTIKVWNTSTCEF--------------------------------------- 422
           YI+SA  D+T  +W+  T E                                        
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351

Query: 423 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 478
             V+T  GH   +  +++     L+ S S D T+++W ++   C+  L+ H + +  I++
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411

Query: 479 -----------DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 527
                       N  + S ++D  +++WD+            +C  TL +H   V+ + F
Sbjct: 412 SPTGPATSNPNSNIMLASASFDSTVRLWDIERG---------VCTHTLTKHQEPVYSVAF 462

Query: 528 --DEFQIVSSSHDDTILIWD 545
             D   + S S D  + IW+
Sbjct: 463 SPDGKYLASGSFDKCVHIWN 482



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 51/235 (21%), Positives = 96/235 (40%), Gaps = 20/235 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 338
           I+S   D T  IWD +T E K+    H+   L + +         S+D  + V  +    
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352

Query: 339 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
            + T   H   V  ++++ +GM++ +CS D ++ +W M     I     L  H   +  +
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTI 409

Query: 397 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 443
            +               + SAS D T+++W+        TL  H+  +  + +    + +
Sbjct: 410 KWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYL 469

Query: 444 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 497
            SGS D  + +W+ + G  +    G   +   C      ++ + A DG + V DL
Sbjct: 470 ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 524


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 72/280 (25%), Positives = 120/280 (42%), Gaps = 30/280 (10%)

Query: 243 IETIESNWRCGRHSLQRIHCRSE------TSKGVYCLQYDDQK--IVSGLRDNTIKIWDK 294
           I  +  N   G   L   HC  E      ++K V  L ++     + +G  D   +IW +
Sbjct: 207 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE 266

Query: 295 NTLECKRILTGHTGSVLCLQYDER--VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
           +       L  H G +  L+++ +   I++   D T  +WD +TGE       H    L 
Sbjct: 267 DG-NLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 325

Query: 353 LRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGD 409
           + + NN    +CS D  I V  +     +   +   GH   VN + +D     + S S D
Sbjct: 326 VDWQNNTTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDD 382

Query: 410 RTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR-----------LVVSGSSDNTIRLWDIE 458
            T+K+W+      +  L  H + I  +++              ++ S S D+T+RLWDIE
Sbjct: 383 MTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 442

Query: 459 CGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 496
            G C   L  H+E V  + F  D K + SG++D  + +W+
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 69/320 (21%), Positives = 125/320 (39%), Gaps = 89/320 (27%)

Query: 302 ILTGHTGSVLCLQYD--ERVIITGSSDSTVRVWDVN---TGEMLNTLIHHC--------- 347
           +L GH   V    ++    ++ +GS DST R+W++N    G     ++ HC         
Sbjct: 176 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235

Query: 348 --EAVLHLRFN-NG-MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 401
             + V  L +N NG ++ T S D    +W      D  L   L  H+  +  + ++ K  
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW----TEDGNLASTLGQHKGPIFALKWNRKGN 291

Query: 402 YIVSASGDRTIKVWNTSTCEF--------------------------------------- 422
           YI+SA  D+T  +W+  T E                                        
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 351

Query: 423 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 478
             V+T  GH   +  +++     L+ S S D T+++W ++   C+  L+ H + +  I++
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411

Query: 479 -----------DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 527
                       N  + S ++D  +++WD+            +C  TL +H   V+ + F
Sbjct: 412 SPTGPATSNPNSNIMLASASFDSTVRLWDIERG---------VCTHTLTKHQEPVYSVAF 462

Query: 528 --DEFQIVSSSHDDTILIWD 545
             D   + S S D  + IW+
Sbjct: 463 SPDGKYLASGSFDKCVHIWN 482



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 51/235 (21%), Positives = 96/235 (40%), Gaps = 20/235 (8%)

Query: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITG-SSDSTVRVWDVNTGE 338
           I+S   D T  IWD +T E K+    H+   L + +         S+D  + V  +    
Sbjct: 293 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 352

Query: 339 MLNTLIHHCEAVLHLRFN-NGMMV-TCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
            + T   H   V  ++++ +GM++ +CS D ++ +W M     I     L  H   +  +
Sbjct: 353 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTI 409

Query: 397 DFDDK-----------YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLV 443
            +               + SAS D T+++W+        TL  H+  +  + +    + +
Sbjct: 410 KWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYL 469

Query: 444 VSGSSDNTIRLWDIECGACLRVLEGHEELVR-CIRFDNKRIVSGAYDGKIKVWDL 497
            SGS D  + +W+ + G  +    G   +   C      ++ + A DG + V DL
Sbjct: 470 ASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 524


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.134    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,933,244
Number of Sequences: 37866
Number of extensions: 985945
Number of successful extensions: 6096
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 2490
Number of HSP's gapped (non-prelim): 1490
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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