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Search of human proteins with 126362969
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126362969 Nck-associated protein 5 isoform 2 [Homo sapiens]
(590 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126362969 Nck-associated protein 5 isoform 2 [Homo sapiens] 1155 0.0
gi|126362967 Nck-associated protein 5 isoform 1 [Homo sapiens] 707 0.0
gi|208022661 hypothetical protein LOC57701 [Homo sapiens] 122 1e-27
gi|31982906 cingulin-like 1 [Homo sapiens] 67 4e-11
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 63 9e-10
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 61 3e-09
gi|21735548 centrosomal protein 2 [Homo sapiens] 59 2e-08
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 59 2e-08
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 59 2e-08
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 58 2e-08
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 58 2e-08
gi|109255236 centrosomal protein 63 isoform d [Homo sapiens] 58 3e-08
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 58 3e-08
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 57 4e-08
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 57 4e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 57 4e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 57 4e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 57 4e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 57 4e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 57 4e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 57 4e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 57 4e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 57 4e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 57 4e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 57 4e-08
gi|55770834 centromere protein F [Homo sapiens] 57 6e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 57 6e-08
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 56 8e-08
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 56 8e-08
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 56 1e-07
>gi|126362969 Nck-associated protein 5 isoform 2 [Homo sapiens]
Length = 590
Score = 1155 bits (2989), Expect = 0.0
Identities = 590/590 (100%), Positives = 590/590 (100%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV
Sbjct: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR
Sbjct: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Query: 121 NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE 180
NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE
Sbjct: 121 NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE 180
Query: 181 KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT 240
KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT
Sbjct: 181 KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT 240
Query: 241 RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA 300
RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA
Sbjct: 241 RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA 300
Query: 301 EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN 360
EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN
Sbjct: 301 EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN 360
Query: 361 LRKRVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYL 420
LRKRVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYL
Sbjct: 361 LRKRVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYL 420
Query: 421 CQPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTAR 480
CQPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTAR
Sbjct: 421 CQPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTAR 480
Query: 481 GMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGT 540
GMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGT
Sbjct: 481 GMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGT 540
Query: 541 QDKAPRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT 590
QDKAPRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT
Sbjct: 541 QDKAPRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT 590
>gi|126362967 Nck-associated protein 5 isoform 1 [Homo sapiens]
Length = 1909
Score = 707 bits (1825), Expect = 0.0
Identities = 365/369 (98%), Positives = 365/369 (98%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV
Sbjct: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR
Sbjct: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Query: 121 NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE 180
NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE
Sbjct: 121 NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE 180
Query: 181 KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT 240
KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT
Sbjct: 181 KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT 240
Query: 241 RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA 300
RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA
Sbjct: 241 RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA 300
Query: 301 EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN 360
EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN
Sbjct: 301 EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN 360
Query: 361 LRKRVKEAN 369
LRKR N
Sbjct: 361 LRKRQSSQN 369
Score = 454 bits (1167), Expect = e-127
Identities = 226/226 (100%), Positives = 226/226 (100%)
Query: 365 VKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPD 424
VKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPD
Sbjct: 1684 VKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPD 1743
Query: 425 SPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARGMRP 484
SPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARGMRP
Sbjct: 1744 SPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARGMRP 1803
Query: 485 LQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQDKA 544
LQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQDKA
Sbjct: 1804 LQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQDKA 1863
Query: 545 PRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT 590
PRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT
Sbjct: 1864 PRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT 1909
>gi|208022661 hypothetical protein LOC57701 [Homo sapiens]
Length = 1334
Score = 122 bits (305), Expect = 1e-27
Identities = 63/85 (74%), Positives = 71/85 (83%)
Query: 185 LLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFD 244
LL RL+ LEAENSALA NENQRE YERCLDEVAN VVQALL QKDLREEC+KLK RVFD
Sbjct: 33 LLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFD 92
Query: 245 LEQQNRTLSILFQQRVRPTSDLLLQ 269
LE+QN+ LS LFQQ+++ T+ L Q
Sbjct: 93 LERQNQMLSALFQQKLQLTTGSLPQ 117
Score = 52.4 bits (124), Expect = 1e-06
Identities = 36/101 (35%), Positives = 45/101 (44%), Gaps = 3/101 (2%)
Query: 358 GKNLRKRVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTG 417
GK K E + +D++A+ V SH RTLDSGIGTFP PD G+ T
Sbjct: 1081 GKPPGKPSSEPGRREEMPSEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTP 1140
Query: 418 RYLCQPDSPEDAEP---LLPLQSALSAVSSMRAQTLEREVP 455
P +P + P + RA TLEREVP
Sbjct: 1141 SKNLPKTKPPRLDPPPGVPPARPPPLTKVPRRAHTLEREVP 1181
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 67.4 bits (163), Expect = 4e-11
Identities = 71/301 (23%), Positives = 141/301 (46%), Gaps = 47/301 (15%)
Query: 18 LDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-----RTSEGAMHEK 72
L L E + + + L ++E + W + +LQ+E+A RTS + +
Sbjct: 918 LSEKLKEESEQKEQLRRLKNEMENER---WHLGKTIEKLQKEMADIVEASRTSTLELQNQ 974
Query: 73 LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK 132
L E+ R + +++L+E TLE+E++R+ +Q + MEE +R+ ++Q K
Sbjct: 975 LDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTK 1034
Query: 133 K---EETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERL 189
+ E+T+ + Y+ + + + L + + D+ S+ E +E + + LL ER+
Sbjct: 1035 RQLLEQTLKDLEYELEAKSHLKDDRSRL--VKQMEDKVSQLE-MELEEERNNSDLLSERI 1091
Query: 190 KALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQN 249
REQ ++++ N+++Q ++DL EC K+ LE+QN
Sbjct: 1092 --------------SRSREQ----MEQLRNELLQERAARQDL--ECDKI-----SLERQN 1126
Query: 250 RTLS---ILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRS---LTQSRTDAEVH 303
+ L I + R + + L+ ++ +R+ +L D L ER+R+ L+ R + +V
Sbjct: 1127 KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE--DRLESEERDRANLQLSNRRLERKVK 1184
Query: 304 E 304
E
Sbjct: 1185 E 1185
Score = 43.9 bits (102), Expect = 4e-04
Identities = 66/320 (20%), Positives = 133/320 (41%), Gaps = 30/320 (9%)
Query: 74 IHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQ----SQGSP 129
+ EL+ + L +++++ ++E E ER R + L+ Q + E L Q S+G
Sbjct: 623 VAELQRQLQLEVKNQQNIKE---ERERMRANLEELRSQHNEKVEENSTLQQRLEESEGEL 679
Query: 130 EQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERL 189
+ EE + + +E+ E R ++ L ++H +D RSE +EK L+ E L
Sbjct: 680 RKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED------REKGALIEELL 733
Query: 190 KALEAENSALALENENQ-----REQYERCLDEVANQVVQALLTQKD-LREEC-VKLKTRV 242
+A + L + E + RE+ L + V + + D L+E+ +L+
Sbjct: 734 QAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALR 793
Query: 243 FDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDL---LSEVERNRSLTQSRTD 299
+E+ + + +L + D ++ +LL + L E+ER + Q + +
Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE 853
Query: 300 AEVHEHQLNTKSALK-----CPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYT 354
++ + K LK L + H + S+ +L + S T
Sbjct: 854 -DLKGDEAKAKETLKKYEGEIRQLEEALV-HARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 355 WHDGKNLRKRVKEANENLQE 374
+ K L +++KE +E ++
Sbjct: 912 TQEQKQLSEKLKEESEQKEQ 931
Score = 33.5 bits (75), Expect = 0.56
Identities = 38/168 (22%), Positives = 78/168 (46%), Gaps = 25/168 (14%)
Query: 134 EETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALE 193
+ T +++ Q++L+++ + + A + L+ + E S +T K K L+ E+++ L+
Sbjct: 534 QATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDAT---KRKVNLVFEKIQTLK 589
Query: 194 AENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLS 253
+ + A N NQ + KDL E+ KL V +L++Q + L
Sbjct: 590 SRAAGSAQGN---------------NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQ-LE 633
Query: 254 ILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAE 301
+ QQ ++ +++ + L +L S +VE N +L Q ++E
Sbjct: 634 VKNQQNIKEER----ERMRANLEELRS-QHNEKVEENSTLQQRLEESE 676
Score = 30.4 bits (67), Expect = 4.8
Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 10/119 (8%)
Query: 13 GKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEK 72
G S LV M++ I L +LE + R +L+ RL+R+V + +
Sbjct: 1138 GSYRSSKEGLVVQMEAR--IAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
Query: 73 LIHELEEERHLRLQSEKRLQEVT------LESERNRIQMRSLQQQFSRMEETVRNLLQS 125
+ + +++ LRL++ KR E LES + ++Q R L++Q M E ++ L S
Sbjct: 1196 SLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQ-RELEEQMD-MNEHLQGQLNS 1252
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 62.8 bits (151), Expect = 9e-10
Identities = 90/401 (22%), Positives = 159/401 (39%), Gaps = 41/401 (10%)
Query: 4 KRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV--- 60
K + ++ D+ + L S +E + L + E R L A LQ E
Sbjct: 1132 KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA 1191
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
A R +L +++ + ++ + EK E LE + M S+ + + +E+ R
Sbjct: 1192 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251
Query: 121 NL----LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
L +++G E+ + + + +L E + LE+ +V + SRS+ + T
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ 1311
Query: 177 EGKEKTKLLLERLKALEAENSALALENEN---QREQYE----------RCLDEVANQVVQ 223
+ +E + L E KA A AL + REQYE R L + ++V Q
Sbjct: 1312 QTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1371
Query: 224 --------ALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRL 275
A+ ++L E KL R+ D E+Q ++ L+K RL
Sbjct: 1372 WRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVN---------AKCASLEKTKQRL 1422
Query: 276 LDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSS 335
DL+ +VER SL + + + ++ + KC A + L + S S S
Sbjct: 1423 QG-EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL--KESRSLS 1479
Query: 336 SEL-SLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQED 375
+EL L + E + KNL + + + E + E+
Sbjct: 1480 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAEN 1520
Score = 48.1 bits (113), Expect = 2e-05
Identities = 76/380 (20%), Positives = 152/380 (40%), Gaps = 34/380 (8%)
Query: 18 LDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHEL 77
L++SL E + + L EE L K L++E+A T + A + K IHEL
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Query: 78 EEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEE-T 136
E+ R +E E+ IQ+ +L++ + +E +L+ Q Q K E
Sbjct: 1528 EKSRK------------QIELEKADIQL-ALEEAEAALEHEEAKILRIQLELTQVKSEID 1574
Query: 137 VNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAEN 196
I E++ + +R ++ +E + +D + RS + + K+K + L ++ +
Sbjct: 1575 RKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI-RLKKKMEGDLNEIEIQLSHA 1633
Query: 197 SALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV----FDLEQQNRTL 252
+ A E + L + + AL Q+DL+E+ ++ R ++E+ TL
Sbjct: 1634 NRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATL 1693
Query: 253 SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSA 312
+ R +LL +LL + L+ ++ + +EV + + ++A
Sbjct: 1694 EQTERARKLAEQELLDSNERVQLLHTQNTSLI-HTKKKLETDLMQLQSEVEDASRDARNA 1752
Query: 313 LKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENL 372
+ + + + ++ + S++ KNL + VK+ L
Sbjct: 1753 EE--------------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1798
Query: 373 QEDEDDAVADSVFQSHIIES 392
E E A+ Q +E+
Sbjct: 1799 DEAEQLALKGGKKQIQKLET 1818
Score = 40.4 bits (93), Expect = 0.005
Identities = 43/199 (21%), Positives = 87/199 (43%), Gaps = 28/199 (14%)
Query: 24 EYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV--AQRTSEGA------------- 68
E +DSN+ ++ L TQ + + + + +LQ EV A R + A
Sbjct: 1706 ELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAM 1765
Query: 69 MHEKLIHELEEERHLRLQSEKRLQEVTLE-----SERNRIQMRSLQQQFSRMEETVRNL- 122
M E+L E + HL + +K L++ + E ++ ++ ++Q ++E +R L
Sbjct: 1766 MAEELKKEQDTSAHLE-RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELE 1824
Query: 123 LQSQGSPEQKKEETVNIMVYQEKL------SEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+ +G ++ E + Y+ ++ SEE+RK+ L+DL + +S +
Sbjct: 1825 FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAE 1884
Query: 177 EGKEKTKLLLERLKALEAE 195
E E+ L + + + E
Sbjct: 1885 EADEQANAHLTKFRKAQHE 1903
Score = 39.7 bits (91), Expect = 0.008
Identities = 55/249 (22%), Positives = 112/249 (44%), Gaps = 46/249 (18%)
Query: 15 RLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWRE-----------KLAVARLQRE---- 59
+ L++ + E + + E + +L + R L E +L +A++++E
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 60 ---VAQRTSE-GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRM 115
V T E + E + E++ L+ ++ L ++ E ++ + SL + S++
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK----VNSLNKTKSKL 1028
Query: 116 EETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLH---MVVDEDSRS-- 170
E+ V +L + S EQ+K+ V++ + KL + + +E++ DL +DE +
Sbjct: 1029 EQQVEDL---ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 1085
Query: 171 ------ESSSTDEG------KEKTKLLLERLKALEAE---NSALALENENQREQYERCLD 215
+S DE ++K K L R++ LE E A + E QR Y R L+
Sbjct: 1086 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 1145
Query: 216 EVANQVVQA 224
E++ ++ +A
Sbjct: 1146 ELSERLEEA 1154
Score = 37.4 bits (85), Expect = 0.039
Identities = 34/144 (23%), Positives = 69/144 (47%), Gaps = 16/144 (11%)
Query: 22 LVEYMDSNKYIEHLLTQLEE-----QHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHE 76
L + D++ ++E + LE+ QHR E+LA+ ++++ + + +L E
Sbjct: 1770 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETR---IRELEFE 1826
Query: 77 LEEERHLRLQS-------EKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNL-LQSQGS 128
LE E+ +S E+R++E+T +SE +R + LQ +++ V++ Q++ +
Sbjct: 1827 LEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEA 1886
Query: 129 PEQKKEETVNIMVYQEKLSEEERK 152
EQ Q +L E E +
Sbjct: 1887 DEQANAHLTKFRKAQHELEEAEER 1910
Score = 35.0 bits (79), Expect = 0.19
Identities = 50/238 (21%), Positives = 101/238 (42%), Gaps = 45/238 (18%)
Query: 71 EKLIHELEEERHLRLQSEKRLQEVTLESER-------------NRIQM------------ 105
E+L E+E ER R ++EK+ + E E +I++
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 106 RSLQQQFSRMEETVRNLLQSQG-SPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVV 164
R L++ + E V L + S + E+ N+ ++KL +E+ + K ++DL +
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 165 DEDSRSESS----------STDEGKEKTKLLLERLKALEAENSALALENENQREQYERCL 214
+ S+S+++ E + K + + L L + S L + + + R L
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRL----QTEAGELSRQL 1292
Query: 215 DEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQ--QRVRPTSDLLLQK 270
+E + V Q +++ ++ +LK + LE++N+ + L Q R DLL ++
Sbjct: 1293 EEKESIVSQLSRSKQAFTQQTEELKRQ---LEEENKAKNALAHALQSSRHDCDLLREQ 1347
Score = 30.4 bits (67), Expect = 4.8
Identities = 46/265 (17%), Positives = 106/265 (40%), Gaps = 54/265 (20%)
Query: 86 QSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGS----------------- 128
++EK + + E ++ + ++ + + +EE + L+Q +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 129 ----------------------PEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDE 166
E ++E + + KL +E + K+ ++DL + + +
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 167 DSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALL 226
+ + ++ + K K L E L L+ + L E + +E +++ LD++ + +
Sbjct: 965 VEKEKHAT----ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV-- 1018
Query: 227 TQKDLREECVKLKTRVFDLE---QQNRTLSILFQQRVRP-TSDLLLQKLHSRLLDLSSG- 281
L + KL+ +V DLE +Q + L + ++ R DL L + +LDL +
Sbjct: 1019 --NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ--ESILDLENDK 1074
Query: 282 DLLSEVERNRSLTQSRTDAEVHEHQ 306
L E + + + ++V + Q
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQ 1099
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 60.8 bits (146), Expect = 3e-09
Identities = 70/310 (22%), Positives = 138/310 (44%), Gaps = 40/310 (12%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
+ L Q EE L REK A+ + +RE A++ + + ++ ++ + L + + +
Sbjct: 743 QRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE 802
Query: 93 EVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQ---GSPEQKKEETVNIMVYQEKLSEE 149
+ ++ R R ++ L+QQ + L+++ G EQ++ + + +++L E
Sbjct: 803 RLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQL-EL 861
Query: 150 ERKHKEA----LEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLK---ALEAENSALALE 202
ER+ EA E+ ++ E E KE +L++ RL+ AL E S A E
Sbjct: 862 ERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKE-IELVIHRLEADMALAKEESEKAAE 920
Query: 203 N--ENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRV 260
+ + R++YE L E+ +++ L+E C +LK ++ + E +N L L +Q+
Sbjct: 921 SRIKRLRDKYEAELSELEQ-------SERKLQERCSELKGQLGEAEGENLRLQGLVRQKE 973
Query: 261 RPTSD-----------------LLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVH 303
R D ++ Q+ RL +S + + + + Q+R E+
Sbjct: 974 RALEDAQAVNEQLSSERSNLAQVIRQEFEDRL--AASEEETRQAKAELATLQARQQLELE 1031
Query: 304 EHQLNTKSAL 313
E K+AL
Sbjct: 1032 EVHRRVKTAL 1041
Score = 35.0 bits (79), Expect = 0.19
Identities = 58/279 (20%), Positives = 118/279 (42%), Gaps = 48/279 (17%)
Query: 49 EKLAVARLQREVAQRTSEGAMHEKLIHELEEER------------HLRLQSEKRLQEVTL 96
EK +LQR+ + H I +L E++ L+ + ++ + V
Sbjct: 606 EKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQ 665
Query: 97 ESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEA 156
++ ++++ L++ S E+ R S+ + + K+ + +KL ++
Sbjct: 666 AQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRR 725
Query: 157 LEDLH--MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALA-LENENQREQYERC 213
L+ LH ++ D R+ + +E + LE E AL E E R+++++
Sbjct: 726 LKSLHEAELLQSDERASQRCLRQAEELR-------EQLEREKEALGQQERERARQRFQQH 778
Query: 214 LDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHS 273
L++ Q L+++ +L + V E++ R L QQ R ++ L++L
Sbjct: 779 LEQ----------EQWALQQQRQRLYSEV--AEERER----LGQQAARQRAE--LEELRQ 820
Query: 274 RLLDLSSG---DLLSEVERNRSLTQSRTDAEVHEHQLNT 309
+L + SS L +E E+ R + R H+ +LNT
Sbjct: 821 QLEESSSALTRALRAEFEKGREEQERR-----HQMELNT 854
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 58.5 bits (140), Expect = 2e-08
Identities = 68/285 (23%), Positives = 132/285 (46%), Gaps = 37/285 (12%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEER----HLRLQS 87
+E L Q++E + +K A+ L ++ +R E + ++ I ELE+ R HL +
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
Query: 88 EKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLS 147
++R Q++T++ E Q+R L++ ET RN+L+ Q +KK++ + Q
Sbjct: 1497 QEREQKLTVQRE----QIRELEKD----RETQRNVLEHQLLELEKKDQMIE---SQRGQV 1545
Query: 148 EEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSA---LALENE 204
++ +K LE L + ++E+ + KL+ E E + A L L+ E
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMEC-------QQKLIKELEGQRETQRVALTHLTLDLE 1598
Query: 205 NQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTS 264
+ ++ + ++ + + + ++L+E ++K++ +E+ R L Q R
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
Query: 265 DLLLQKLHSRLLD--------LSSGDL----LSEVERNRSLTQSR 297
+L+LQK ++L+ + DL LS ER R LT R
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR 1703
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/364 (23%), Positives = 147/364 (40%), Gaps = 72/364 (19%)
Query: 6 QLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREK-------------LA 52
QL+ K L L+SSL E N IE QLE Q +++ + K L
Sbjct: 758 QLQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELD 816
Query: 53 VARLQ---------REVAQRTSEG--------AMHEKLIHEL----EEERHLRLQSEKRL 91
R Q R++AQ EG A HEK +++L E+ER Q +
Sbjct: 817 TERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA 876
Query: 92 QEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEER 151
E +LE E+ ++MR +QQ T +Q+Q E+ + E+ + Q +L E
Sbjct: 877 LE-SLEREKMELEMRLKEQQ------TEMEAIQAQREEERTQAESA---LCQMQLETE-- 924
Query: 152 KHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQRE--- 208
KE + L ++ +S + + + +++LK E E QRE
Sbjct: 925 --KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982
Query: 209 ---QYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSD 265
Q+ L + + L + DL+++ LK+++ + R + Q+++R T +
Sbjct: 983 AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
Query: 266 ----------------LLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNT 309
L L + RLL L D + + E + +L Q +A+ + +L+
Sbjct: 1043 YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS-ALRQDMQEAQGEQKELSA 1101
Query: 310 KSAL 313
+ L
Sbjct: 1102 QMEL 1105
Score = 44.7 bits (104), Expect = 2e-04
Identities = 70/299 (23%), Positives = 120/299 (40%), Gaps = 54/299 (18%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L QLE+Q + L R+ V ++QR E + ++ + E E+ L+ QS
Sbjct: 1748 LQELKDQLEQQLQGLHRK---VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS---- 1800
Query: 92 QEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEER 151
L+S+ + Q R+L Q+ +E + Q+QG E+ KE+ +
Sbjct: 1801 ----LQSQLDEAQ-RALAQRDQELEALQQEQQQAQGQEERVKEKADAL------------ 1843
Query: 152 KHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLE-------RLKALEAENSALALENE 204
+ ALE HM + E + KE+ + L E R++ALE L E+
Sbjct: 1844 --QGALEQAHMTLKE----RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
Query: 205 NQREQ----YERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLE------QQNRTLSI 254
Q + ++C ++ V+ Q + LK R +LE Q +R
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957
Query: 255 LFQQRVRPTSDLLLQKLHSRLLD-----LSSGDLLSEVERNRSLTQSRTDA-EVHEHQL 307
+ R + L K H+ L L +L +E + + Q+ DA + H QL
Sbjct: 1958 AARARAEALQE-ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQL 2015
Score = 44.3 bits (103), Expect = 3e-04
Identities = 53/251 (21%), Positives = 100/251 (39%), Gaps = 36/251 (14%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L QLE + WR + LQ + + A +K E +EE HL ++ +RLQ
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQ-----GDSAQGQK--EEQQEELHLAVRERERLQ 525
Query: 93 EVT-------------------------LESERNRIQMRSLQQQFSRMEETVRNLLQSQG 127
E+ LE E R + + +R E+++ L S+
Sbjct: 526 EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 128 SPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLE 187
+ + + + V L+E K L + ++E+++S S + ++ L
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
Query: 188 RLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQ 247
L E AL +N + Q ++ E A +QA L +D++EE +++ ++ +
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKA--EEAGAELQADL--RDIQEEKEEIQKKLSESRH 701
Query: 248 QNRTLSILFQQ 258
Q + +Q
Sbjct: 702 QQEAATTQLEQ 712
Score = 43.1 bits (100), Expect = 7e-04
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 46/244 (18%)
Query: 86 QSEKRLQEVTLESERNRIQM----RSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMV 141
Q+ LQ E+E+ R + L+ Q + EE L +++KEE
Sbjct: 638 QARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----- 692
Query: 142 YQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALAL 201
Q+KLSE + + A L + E R E +EK L+ E+ ALE A+
Sbjct: 693 -QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK-AALEVRLQAVER 750
Query: 202 ENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSI------L 255
+ ++ EQ +Q L + K+L L++ +F+ +QQN + + +
Sbjct: 751 DRQDLAEQ------------LQGLSSAKEL------LESSLFEAQQQNSVIEVTKGQLEV 792
Query: 256 FQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERN---RSLTQSRTDAE--------VHE 304
Q V +++ ++ L+L + +E ER+ R L Q+ + + HE
Sbjct: 793 QIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHE 852
Query: 305 HQLN 308
++N
Sbjct: 853 KEVN 856
Score = 38.9 bits (89), Expect = 0.013
Identities = 51/210 (24%), Positives = 88/210 (41%), Gaps = 27/210 (12%)
Query: 34 HLLTQLEEQHRSLWREKLAVARLQR--EVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
H Q +EQH L A L R E + T + ++ H + E LR+Q E +
Sbjct: 1974 HAALQGKEQHL------LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQ-EGEI 2026
Query: 92 QEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEER 151
Q+ L + + ++ LQQ ++ +E +R+ + + E+ + V + QEK + +
Sbjct: 2027 QDQDLRYQED---VQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQE 2083
Query: 152 KHKEALEDLHMVVDE------DSRSESSSTDEGKEKTKL--LLERLKALEAENSALALEN 203
+ +E + LH V E E E +++ L L K E +L L++
Sbjct: 2084 REEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143
Query: 204 ENQREQYERCLDEVANQVVQALLTQKDLRE 233
R Q E + +QA L Q + RE
Sbjct: 2144 LEPRLQREL-------ERLQAALRQTEARE 2166
Score = 36.2 bits (82), Expect = 0.087
Identities = 71/317 (22%), Positives = 129/317 (40%), Gaps = 65/317 (20%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEK---RLQEVTLESER 100
RSL++ + L E A ++ +H+ L + LR Q +K RL + E +
Sbjct: 1224 RSLFKRGPLLTALSAE-AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282
Query: 101 NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDL 160
+++ LQ+Q S+ +E +S+ +Q E+ + +++ S + R + L+ +
Sbjct: 1283 VHTELQDLQRQLSQNQEE-----KSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 161 HMVVDEDSRSESSSTDEGKEKTKLLLERLKA------------------LEAENSALALE 202
+++ E KE +E L+A L SAL L+
Sbjct: 1338 ------EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLK 1391
Query: 203 N---ENQREQYERCLDEVANQVVQ--------ALLTQ--KDLREECVKLKTRVFDLEQQN 249
N E++RE+ + ++ +V Q ALLTQ + EE L+ ++ +LE+Q
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451
Query: 250 R----TLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDL----LSEVERNRSLTQSR---- 297
L +L + ++ LQ+ + L+ L ++ ER + LT R
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511
Query: 298 -------TDAEVHEHQL 307
T V EHQL
Sbjct: 1512 ELEKDRETQRNVLEHQL 1528
Score = 30.4 bits (67), Expect = 4.8
Identities = 57/290 (19%), Positives = 118/290 (40%), Gaps = 38/290 (13%)
Query: 6 QLEKRDFGKRLSLDSSLV----EYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVA 61
Q++ +R+SL +L+ E D+++ +E L ++ Q + +E + + Q + A
Sbjct: 918 QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ-KLKEQETTGILQTQLQEA 976
Query: 62 QRTSEGA--MHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETV 119
QR + A H + L+EE LQ + LQ+ Q+ L+ Q ++
Sbjct: 977 QRELKEAARQHRDDLAALQEESSSLLQDKMDLQK----------QVEDLKSQLVAQDD-- 1024
Query: 120 RNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGK 179
SQ EQ+ +E + ++ +E + K +L M ++ + +
Sbjct: 1025 -----SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079
Query: 180 EKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQAL-------LTQKDLR 232
++ L + ++ + E L+ + E R++ + + Q Q L +T++ LR
Sbjct: 1080 QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
Query: 233 -------EECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRL 275
+ +L+ R+ E Q L+ Q + + L L+S L
Sbjct: 1140 ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/216 (24%), Positives = 100/216 (46%), Gaps = 35/216 (16%)
Query: 38 QLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRL-QSEKRLQEVTL 96
++ EQ +WR++ + ++ ++ E E+ I E EE+R ++ + EK+++E
Sbjct: 361 KIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMRE--- 417
Query: 97 ESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEA 156
+ E+ R Q +++ R EE +R L + E+K E +EK+ EEE K +E
Sbjct: 418 QDEKIREQ----EEEMWRQEEKIRELEEMMQDQEEKLREV------EEKMQEEEEKMQEQ 467
Query: 157 LEDLHMVVDEDSRSESSSTDEGKEKT----KLLLERLKALEAENSALALEN--------- 203
+E + + E +EKT KLL + K E E E
Sbjct: 468 --------EEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKM 519
Query: 204 ENQREQYERCLDEVANQVVQALLTQKDLREECVKLK 239
+ Q E+ +R +++ Q V+ ++ ++E+ V+L+
Sbjct: 520 QEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ 555
Score = 48.5 bits (114), Expect = 2e-05
Identities = 41/179 (22%), Positives = 83/179 (46%), Gaps = 11/179 (6%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E + Q E++ +WR++ + ++ ++ E E+ I ELEE + E++L+
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE---MMQDQEEKLR 451
Query: 93 EVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQ--KKEETV-----NIMVYQEK 145
EV + + +M+ +++ R EE ++ + E+ K+EE + + +EK
Sbjct: 452 EVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511
Query: 146 LSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENE 204
+ E+E K +E E + +E R + + +EK + RL+ LE L + E
Sbjct: 512 MWEQEEKMQEQEEKMQR-QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/232 (21%), Positives = 97/232 (41%), Gaps = 41/232 (17%)
Query: 38 QLEEQHRSLWREKLAVARLQ----------REVAQRTSEGAMHEKLIHELEE-----ERH 82
++ EQ +WR++ + L+ REV ++ E E+ + E EE E
Sbjct: 421 KIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE---EEEKMQEQEEKIQRQEEK 477
Query: 83 LRLQSEKRLQEVTLESERNRI---------QMRSLQQQFSRMEETVRNLLQSQGSPEQKK 133
++ Q EK ++ L + +I Q + +Q +M+E + Q E+ +
Sbjct: 478 IQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKM---QRQEEKMR 534
Query: 134 EETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEK----TKLLLERL 189
E+ V + +EK+ E+E + +E E L + + + + G ++ T +L L
Sbjct: 535 EQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVEL 594
Query: 190 KALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTR 241
K+ EA++ + Q++ Y L + Q L + K+ C K R
Sbjct: 595 KSQEAQSL------QQQQDHYRGHLQQYV-AAYQQLASGKEALPSCSSRKLR 639
Score = 43.1 bits (100), Expect = 7e-04
Identities = 41/220 (18%), Positives = 101/220 (45%), Gaps = 5/220 (2%)
Query: 38 QLEEQHRSLWREKLAV-ARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTL 96
QL+ + L +E +V A+LQ +V + ++++ ++ + + E+++ E L
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 97 ESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK-KEETVNIMVYQEKLSEEERKHKE 155
+ +M +++ EE +R E+K +E+ I +EK+ +E K +E
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 156 ALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYE--RC 213
E + +E R E ++ +++ + + + K + ++ + + E Q E R
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 214 LDEVANQVVQALL-TQKDLREECVKLKTRVFDLEQQNRTL 252
L+E+ + L ++ ++EE K++ + +++Q +
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKI 478
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 42/264 (15%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
ME + KR KR D L E DS + E L E V+ +++
Sbjct: 69 MEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNS 128
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEK---RLQEVTLESERNRIQMRSLQQQFSRMEE 117
+ S ++ ++E R+ +K RL EVT + + + S +EE
Sbjct: 129 DEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQK----------RPENSLLEE 178
Query: 118 TVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDE 177
T+ + V + Y EKL++E + +LE + ++ E
Sbjct: 179 TLHF------------DHAVRMGTYIEKLTKE--RDAPSLELYRNTITDE---------E 215
Query: 178 GKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQ--KDLREEC 235
KEK L E+L+ +E+E S + L ++ + + ER + Q +Q + K+L+
Sbjct: 216 LKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVS 275
Query: 236 VKLKTRVFDLEQQNRTLSILFQQR 259
KL+ +V ++N ++L QQ+
Sbjct: 276 AKLQAQV----EENELWNLLNQQQ 295
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/216 (24%), Positives = 100/216 (46%), Gaps = 35/216 (16%)
Query: 38 QLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRL-QSEKRLQEVTL 96
++ EQ +WR++ + ++ ++ E E+ I E EE+R ++ + EK+++E
Sbjct: 361 KIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMRE--- 417
Query: 97 ESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEA 156
+ E+ R Q +++ R EE +R L + E+K E +EK+ EEE K +E
Sbjct: 418 QDEKIREQ----EEEMWRQEEKIRELEEMMQDQEEKLREV------EEKMQEEEEKMQEQ 467
Query: 157 LEDLHMVVDEDSRSESSSTDEGKEKT----KLLLERLKALEAENSALALEN--------- 203
+E + + E +EKT KLL + K E E E
Sbjct: 468 --------EEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKM 519
Query: 204 ENQREQYERCLDEVANQVVQALLTQKDLREECVKLK 239
+ Q E+ +R +++ Q V+ ++ ++E+ V+L+
Sbjct: 520 QEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ 555
Score = 48.5 bits (114), Expect = 2e-05
Identities = 41/179 (22%), Positives = 83/179 (46%), Gaps = 11/179 (6%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E + Q E++ +WR++ + ++ ++ E E+ I ELEE + E++L+
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE---MMQDQEEKLR 451
Query: 93 EVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQ--KKEETV-----NIMVYQEK 145
EV + + +M+ +++ R EE ++ + E+ K+EE + + +EK
Sbjct: 452 EVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511
Query: 146 LSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENE 204
+ E+E K +E E + +E R + + +EK + RL+ LE L + E
Sbjct: 512 MWEQEEKMQEQEEKMQR-QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/232 (21%), Positives = 97/232 (41%), Gaps = 41/232 (17%)
Query: 38 QLEEQHRSLWREKLAVARLQ----------REVAQRTSEGAMHEKLIHELEE-----ERH 82
++ EQ +WR++ + L+ REV ++ E E+ + E EE E
Sbjct: 421 KIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE---EEEKMQEQEEKIQRQEEK 477
Query: 83 LRLQSEKRLQEVTLESERNRI---------QMRSLQQQFSRMEETVRNLLQSQGSPEQKK 133
++ Q EK ++ L + +I Q + +Q +M+E + Q E+ +
Sbjct: 478 IQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKM---QRQEEKMR 534
Query: 134 EETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEK----TKLLLERL 189
E+ V + +EK+ E+E + +E E L + + + + G ++ T +L L
Sbjct: 535 EQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVEL 594
Query: 190 KALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTR 241
K+ EA++ + Q++ Y L + Q L + K+ C K R
Sbjct: 595 KSQEAQSL------QQQQDHYRGHLQQYV-AAYQQLASGKEALPSCSSRKLR 639
Score = 43.1 bits (100), Expect = 7e-04
Identities = 41/220 (18%), Positives = 101/220 (45%), Gaps = 5/220 (2%)
Query: 38 QLEEQHRSLWREKLAV-ARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTL 96
QL+ + L +E +V A+LQ +V + ++++ ++ + + E+++ E L
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 97 ESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK-KEETVNIMVYQEKLSEEERKHKE 155
+ +M +++ EE +R E+K +E+ I +EK+ +E K +E
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 156 ALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYE--RC 213
E + +E R E ++ +++ + + + K + ++ + + E Q E R
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 214 LDEVANQVVQALL-TQKDLREECVKLKTRVFDLEQQNRTL 252
L+E+ + L ++ ++EE K++ + +++Q +
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKI 478
Score = 33.1 bits (74), Expect = 0.73
Identities = 60/264 (22%), Positives = 109/264 (41%), Gaps = 42/264 (15%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
ME + KR KR D L E DS + E L E V+ +++
Sbjct: 69 MEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNS 128
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEK---RLQEVTLESERNRIQMRSLQQQFSRMEE 117
+ S ++ ++E R+ +K RL EVT + + + S +EE
Sbjct: 129 DEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQK----------RPENSLLEE 178
Query: 118 TVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDE 177
T+ + V + Y EKL++E ++AL + + + +E
Sbjct: 179 TLHF------------DHAVRMGTYIEKLTKE----RDALS-------LELYRNTITDEE 215
Query: 178 GKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQ--KDLREEC 235
KEK L E+L+ +E+E S + L ++ + + ER + Q +Q + K+L+
Sbjct: 216 LKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVS 275
Query: 236 VKLKTRVFDLEQQNRTLSILFQQR 259
KL+ +V ++N ++L QQ+
Sbjct: 276 AKLQAQV----EENELWNLLNQQQ 295
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 58.2 bits (139), Expect = 2e-08
Identities = 74/321 (23%), Positives = 138/321 (42%), Gaps = 41/321 (12%)
Query: 15 RLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEG-AMHEKL 73
RL+L++ E S E L+ ++EE R + ++ +++++ +EG ++ KL
Sbjct: 473 RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
Query: 74 IHELEEERHLRLQSEKRLQEVTLESE-------RNRIQMRSLQQQFSRMEETVRNLLQSQ 126
+L +E+ Q E ++T E + ++ + + L ++E+ V NL+
Sbjct: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
Query: 127 GSPEQKKEETVNIMVYQEKLSEEERKHKEALE----DLHMVVDEDSRSESSST--DEGKE 180
+ +E V+I +L E R+++E L +L +++DS S T E +
Sbjct: 593 N---KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649
Query: 181 KTKLLLERLKALEA--------------ENSALALENENQREQYERC------LDEVANQ 220
+ + L + L LE EN L L E+ R Q E C L N
Sbjct: 650 EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNT 709
Query: 221 VVQALLTQK-DLREECVKLKTRVF-DLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDL 278
+V+ L +K ++ E K R+ + + +T+ L R TS L L+ H L+ L
Sbjct: 710 IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLE--HEHLIKL 767
Query: 279 SSGDLLSEVERNRSLTQSRTD 299
+ + E +++ Q TD
Sbjct: 768 NQKKDMEIAELKKNIEQMDTD 788
Score = 43.9 bits (102), Expect = 4e-04
Identities = 62/294 (21%), Positives = 125/294 (42%), Gaps = 27/294 (9%)
Query: 16 LSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREK----LAVARLQREVAQRTSEGAMHE 71
L+ D+SL E N ++ + LE++ L +EK +++ +L E S
Sbjct: 407 LNQDNSLAE---DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDI 463
Query: 72 KLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQ 131
L EL + LRL E + QE+ + +++ + +E ++++ + +
Sbjct: 464 SLDSELHD---LRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSK 520
Query: 132 KKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED--------SRSESSSTDEGKEKTK 183
++ E +I+ ++ +E+K LED M + ++ +SE + D K K
Sbjct: 521 QQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQK 580
Query: 184 L------LLERLKALEAENSALALENENQRE---QYERCLDEVANQVVQALLTQKDLREE 234
L L+++L + N ++ EN +E Q E L + N+++Q+L + +
Sbjct: 581 LEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFK 640
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVE 288
LK R ++ + LS L Q K+ + L L+ D+ ++E
Sbjct: 641 DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLE 694
Score = 41.2 bits (95), Expect = 0.003
Identities = 64/276 (23%), Positives = 122/276 (44%), Gaps = 37/276 (13%)
Query: 18 LDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHEL 77
L L +Y + + E L +EE+ RSL K LQ E+ +R E
Sbjct: 827 LQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEEL-ERLRE----------- 874
Query: 78 EEERHLRLQSEKRLQEVT-LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEET 136
E+ R + K L VT L SE + Q+ ++++ +EE +++ + Q K +
Sbjct: 875 EQSRTAPVADPKTLDSVTELASEVS--QLNTIKE---HLEEEIKHHQKIIEDQNQSKMQL 929
Query: 137 VNIMVYQEKLSEEERKHKEALEDLH--MVVDEDSRSESSSTDEGKEKTKLLLERLKALEA 194
+ + Q+K +E R E + H + +++D +S + KT+L ER + ++
Sbjct: 930 LQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEER-QDIQT 988
Query: 195 ENS---------ALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKTRVFD 244
+NS +L +EN +++ + + + + + L K L E+ + L ++
Sbjct: 989 DNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQ 1048
Query: 245 LEQQN-RTLSILFQQRVRPTSDLLLQKLHSRLLDLS 279
L + L+ + QQ+ DL +Q LH+R+ S
Sbjct: 1049 LSKDEVGKLTQIIQQK-----DLEIQALHARISSTS 1079
Score = 39.7 bits (91), Expect = 0.008
Identities = 68/316 (21%), Positives = 134/316 (42%), Gaps = 30/316 (9%)
Query: 84 RLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQ--SQGSPEQKKEETVNIMV 141
RL+SE ++ + + S Q + +++ ++ L Q SQ + + E +V
Sbjct: 183 RLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNA 242
Query: 142 YQEKLSEEERKHKEALEDLHMVVDE------DSRSESSSTDEGK----EKTKLLLERLKA 191
+Q+KL+E R+H+E L D ++E S TD K +KT +L+ ++
Sbjct: 243 HQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ-IEK 301
Query: 192 LEAENSALALENE-----NQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLE 246
+E+ LE++ + E D + + Q + ++ + EEC LK L+
Sbjct: 302 VESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQ 361
Query: 247 ----QQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDL-LSEVERNRSLTQSRTDAE 301
+Q+ T++ + + S + +L L D + + LS + ++ SL + +
Sbjct: 362 PSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLK 421
Query: 302 VHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGK-N 360
+ L + +L + L N Y E+ S+ + S S HD + N
Sbjct: 422 MRIEVLEKEKSLLSQEKEELQMSLLKLNNEY----EVIKSTATRDISLDSEL--HDLRLN 475
Query: 361 LRKRVKEANENLQEDE 376
L + +E N+++ E E
Sbjct: 476 LEAKEQELNQSISEKE 491
Score = 34.7 bits (78), Expect = 0.25
Identities = 43/207 (20%), Positives = 93/207 (44%), Gaps = 29/207 (14%)
Query: 27 DSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-RTSE--------GAMHEK-LIHE 76
++N +L + E + S+ + LA +L +E Q +T E +M EK ++ +
Sbjct: 1484 ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQ 1543
Query: 77 LEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEET 136
E ++ + +K+++ L++E R++ + + +E +LL+S+ S
Sbjct: 1544 QERDQVMLALKQKQMENTALQNEVQRLRDKEFRSN-QELERLRNHLLESEDS-------- 1594
Query: 137 VNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKL----LLERLKAL 192
+E L+ E+R+ K L V++E S S++ + + + L E+L +
Sbjct: 1595 ----YTREALAAEDREAK--LRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
Query: 193 EAENSALALENENQREQYERCLDEVAN 219
+ AL+ +EQ ++ +AN
Sbjct: 1649 SKQRDETALQLSVSQEQVKQYALSLAN 1675
Score = 33.1 bits (74), Expect = 0.73
Identities = 32/170 (18%), Positives = 74/170 (43%), Gaps = 13/170 (7%)
Query: 88 EKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLS 147
++ L+E+ + +R+LQ+ R+ +++ + + ++ + + + ++ +
Sbjct: 1346 QQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL 1405
Query: 148 EEERKHKEAL----EDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALEN 203
++ K K+ L D + +E+ ++ + + ++ L ER+ LE + L EN
Sbjct: 1406 QKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGEN 1465
Query: 204 ENQREQYE------RCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQ 247
E E Y + L E N +L +K+ EC +K + EQ
Sbjct: 1466 EKIVETYRGKETEYQALQE-TNMKFSMMLREKEF--ECHSMKEKALAFEQ 1512
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/266 (26%), Positives = 122/266 (45%), Gaps = 23/266 (8%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQ-RTSEGAMHEKLIHELEEERHLRLQSEKRL 91
E L +LE Q R L + ARL +E+AQ R +E H + + E+ LR E
Sbjct: 742 EALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAG 801
Query: 92 QEVTLESERNRIQMRSLQQ--QFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQE-KLSE 148
QE+ S+ + +L + R E + L++Q +++ + + Q + +E
Sbjct: 802 QELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAE 861
Query: 149 EERKHKEALE-DLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQR 207
ER+ KEAL+ +L V + +E + LER + L E E+Q
Sbjct: 862 RERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLR--------EKESQH 913
Query: 208 EQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLL 267
++Y+ L++ +QA T K+ E ++LKTR LE++ LFQ R P
Sbjct: 914 QRYQG-LEQRLEAELQAAATSKE--EALMELKTRALQLEEE------LFQLRQGPAGLGP 964
Query: 268 LQKLHSRLLDLSSGDLLSEVERNRSL 293
++ +L++ + L+ EVER+ ++
Sbjct: 965 KKRAEPQLVETQNVRLI-EVERSNAM 989
Score = 45.4 bits (106), Expect = 1e-04
Identities = 75/291 (25%), Positives = 130/291 (44%), Gaps = 44/291 (15%)
Query: 36 LTQLEEQHRSLWREKLAV-ARLQREVAQRTS-EGAMHEKLIHELEEERHL-RLQSEKRLQ 92
L ++E + L EK A+ +LQ Q S +G E L+ + H RLQ+EK +
Sbjct: 980 LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVL 1039
Query: 93 EVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERK 152
E IQ + L ++ +EE VR QSQ E+ + + ++ + L++ +R+
Sbjct: 1040 E---------IQGQELHRKLEVLEEEVRAARQSQ---EETRGQQQALLRDHKALAQLQRR 1087
Query: 153 HKEALEDL---HMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENEN--QR 207
+ LE L H + + R+ + E + + + L + ++EA+ AL E E Q
Sbjct: 1088 QEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQD 1147
Query: 208 EQYERCLDEVANQV------VQALLTQ-----KDLREECVKLKTRVFDLEQQNRTLSILF 256
+R L+E ++ Q LL + +L+ E +L+ R+ LE + L +
Sbjct: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS 1207
Query: 257 QQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQL 307
QQ + ++ LDLS+ L ++ E LTQ R+ E QL
Sbjct: 1208 QQ----------LRESNQQLDLSACRLTTQCE---LLTQLRSAQEEENRQL 1245
Score = 32.0 bits (71), Expect = 1.6
Identities = 25/97 (25%), Positives = 49/97 (50%), Gaps = 16/97 (16%)
Query: 14 KRLSLDSSLVEYMDSNKYIE----------HLLTQL----EEQHRSLWREKLAVARLQRE 59
+R L+ + +SN+ ++ LLTQL EE++R L E A++R RE
Sbjct: 1199 ERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRE 1258
Query: 60 VAQRTSEGA--MHEKLIHELEEERHLRLQSEKRLQEV 94
+ +R+ E +H + L++ LR + +K ++++
Sbjct: 1259 LLERSLESRDHLHREQREYLDQLNALRREKQKLVEKI 1295
Score = 31.2 bits (69), Expect = 2.8
Identities = 48/250 (19%), Positives = 94/250 (37%), Gaps = 33/250 (13%)
Query: 62 QRTSEGAMH----------EKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQ 111
Q+ SEGA+ E L + E+ LR + + ++ + Q R L+ Q
Sbjct: 699 QQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQ 758
Query: 112 FSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSE----------EERKHKEALEDLH 161
+ + L Q++ + + E Q +L E + +EAL +
Sbjct: 759 NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEAL 818
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQV 221
+ R + +++ ER++ LE+E E E +R + E E+ V
Sbjct: 819 AAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAV 878
Query: 222 VQAL-------LTQKDLREECVKLKTRVFDLEQQNRTLSILFQ------QRVRPTSDLLL 268
V+ Q++L + ++ + + + E Q++ L Q Q + + L
Sbjct: 879 VRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEAL 938
Query: 269 QKLHSRLLDL 278
+L +R L L
Sbjct: 939 MELKTRALQL 948
>gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
Length = 475
Score = 57.8 bits (138), Expect = 3e-08
Identities = 70/333 (21%), Positives = 145/333 (43%), Gaps = 41/333 (12%)
Query: 4 KRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEE---------QHRSLWREKLAVA 54
KR EK + + + + IE L ++EE + R +++++++
Sbjct: 111 KRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL 170
Query: 55 RLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESER-------NRIQMRS 107
QR+ SE + +L++ ++ + L S+ +Q ++ + ER N +++
Sbjct: 171 EAQRKALAEQSE-IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIER 229
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
L + + + T +LQ Q E+K E+ ++ E L EE+R+ K AL+
Sbjct: 230 LTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL---EALQEEKRELKAALQ--------- 277
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQR---EQYERCLDEVANQVVQA 224
S+ + E + + + L E++KA +++ A+ E+ +Q + L E ++ +
Sbjct: 278 --SQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRM 335
Query: 225 LLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSS--GD 282
+ + E KLK ++ EQ + + ++ L Q+LH R + ++S G
Sbjct: 336 EAHNNEYKAEIKKLKEQILQGEQSYSSA----LEGMKMEISHLTQELHQRDITIASTKGS 391
Query: 283 LLSEVERNRSLTQSRTDAEV-HEHQLNTKSALK 314
+R R+ Q D V H+ L+ +LK
Sbjct: 392 SSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 57.8 bits (138), Expect = 3e-08
Identities = 70/333 (21%), Positives = 145/333 (43%), Gaps = 41/333 (12%)
Query: 4 KRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEE---------QHRSLWREKLAVA 54
KR EK + + + + IE L ++EE + R +++++++
Sbjct: 111 KRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSL 170
Query: 55 RLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESER-------NRIQMRS 107
QR+ SE + +L++ ++ + L S+ +Q ++ + ER N +++
Sbjct: 171 EAQRKALAEQSE-IIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIER 229
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
L + + + T +LQ Q E+K E+ ++ E L EE+R+ K AL+
Sbjct: 230 LTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL---EALQEEKRELKAALQ--------- 277
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQR---EQYERCLDEVANQVVQA 224
S+ + E + + + L E++KA +++ A+ E+ +Q + L E ++ +
Sbjct: 278 --SQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKRM 335
Query: 225 LLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSS--GD 282
+ + E KLK ++ EQ + + ++ L Q+LH R + ++S G
Sbjct: 336 EAHNNEYKAEIKKLKEQILQGEQSYSSA----LEGMKMEISHLTQELHQRDITIASTKGS 391
Query: 283 LLSEVERNRSLTQSRTDAEV-HEHQLNTKSALK 314
+R R+ Q D V H+ L+ +LK
Sbjct: 392 SSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 424
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/310 (26%), Positives = 136/310 (43%), Gaps = 51/310 (16%)
Query: 20 SSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEE 79
S ++E ++ T+L+EQ S EK+ VA L+ E+AQ +LE
Sbjct: 3131 SQMLEMQVELSSMKDRATELQEQLSS---EKMVVAELKSELAQT------------KLEL 3175
Query: 80 ERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNI 139
E L+ Q K L+E+ E R++++ + + +T+ + EQKK +
Sbjct: 3176 ETTLKAQ-HKHLKEL----EAFRLEVKDKTDEVHLLNDTLAS--------EQKKSRELQW 3222
Query: 140 MVYQEK--LSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENS 197
+ +EK L E + KE LEDL ++ S + + LLLE+ K L E+
Sbjct: 3223 ALEKEKAKLGRSEERDKEELEDLKFSLE--------SQKQRNLQLNLLLEQQKQLLNESQ 3274
Query: 198 ALALENENQREQYERCLDEVA--NQVVQALLTQKDLR-EECVKLKTRVFDLEQQNRTLSI 254
+ E+QR Y+ L E N +Q LL + +R E R +L Q ++
Sbjct: 3275 Q---KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331
Query: 255 LFQQRVR-PTSDLL------LQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQL 307
Q R P+ DLL L++ HSR+++L + +++ ++ Q D +VH L
Sbjct: 3332 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3391
Query: 308 NTKSALKCPG 317
T+ G
Sbjct: 3392 QTEQEANTEG 3401
Score = 53.1 bits (126), Expect = 7e-07
Identities = 67/307 (21%), Positives = 141/307 (45%), Gaps = 36/307 (11%)
Query: 28 SNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQS 87
++K + L Q+ ++++ + KL + +++ Q + E + EL++ H Q
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 88 EKRL-QEVTLESERNRIQMRSL------QQQFSRMEETVR-NLLQSQGSPEQKKEETVNI 139
E + Q + E++R Q+R+ QQ +E +R ++ Q + + K E N
Sbjct: 415 ETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENA 474
Query: 140 MVYQEKLSEEERKHK---EALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAEN 196
+ ++ E + K A+ +L++ + + + S ++ KE+ L+LE AL+ +
Sbjct: 475 LRSYSNITVNEDQIKLMNVAINELNIKLQDTN----SQKEKLKEELGLILEEKCALQRQL 530
Query: 197 SALALENENQREQYERCLDEVA------NQVVQALLTQKDLREECVKLKTRVFDLEQQNR 250
L E REQ +R +A N+ ++L T +DL+ E V +LE ++
Sbjct: 531 EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHE 590
Query: 251 TLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRS---------LTQSRTDAE 301
++ ++ +L+K + +LD + +E+ER R+ L++ + D E
Sbjct: 591 AEVTNYKIKLE-----MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE 645
Query: 302 VHEHQLN 308
+ EH++N
Sbjct: 646 I-EHRIN 651
Score = 49.7 bits (117), Expect = 8e-06
Identities = 70/304 (23%), Positives = 134/304 (44%), Gaps = 46/304 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKL-IHELEEERHLRLQSEKR 90
+E L TQL H E+L+ + E+ R + + + L IH ++ L+ + ++
Sbjct: 622 LERLRTQLLFSHE----EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQK 677
Query: 91 LQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLS--E 148
++ + E + + L + S++++ ++L+ S+ +E T+ I Q+++
Sbjct: 678 IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS-----EEMTLQINELQKEIEILR 732
Query: 149 EERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQRE 208
+E K K LE V E + KEK L E+ LEAENS L E + +
Sbjct: 733 QEEKEKGTLEQ---EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
Query: 209 ---------QYERCL----------DEVANQVVQALLTQ-KDLREECVKLKTRVFDLEQQ 248
Q ER + D V + ++ L+ + +DL+++C++L ++E+Q
Sbjct: 790 MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNE---EIEKQ 846
Query: 249 NRTLSILFQQRVRPTSDLLLQKLHSRLL----DLSSGDLLSEVERNRSLTQSRTDAEVHE 304
T S F ++ + LQ+ ++ LL DL E+E L + E+H
Sbjct: 847 RNTFS--FAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL--KALNEELHL 902
Query: 305 HQLN 308
++N
Sbjct: 903 QRIN 906
Score = 48.1 bits (113), Expect = 2e-05
Identities = 58/260 (22%), Positives = 115/260 (44%), Gaps = 41/260 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
+E L L+E+ L+ +LQR++ +R E E + ELE+ + + +++
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170
Query: 92 Q----------------EVTLESERNRI-----QMRSLQQQFSRMEETVRNLLQSQGSPE 130
+ EV L++ER+ I ++ +L++Q + E + N +
Sbjct: 2171 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2230
Query: 131 -----QKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLL 185
QKKE T + ++L +E + K+ +E L + + E S++ ST +
Sbjct: 2231 MQLEIQKKESTTRL----QELEQENKLFKDDMEKLGLAIKE---SDAMSTQDQHVLFGKF 2283
Query: 186 LERLKALEAENSALALENENQREQYERCLD----EVANQVVQALLTQKDL---REECVKL 238
+ ++ E E L + ++Q + D E N++++ L TQ + +ECVK
Sbjct: 2284 AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK- 2342
Query: 239 KTRVFDLEQQNRTLSILFQQ 258
+ R ++EQ N + L Q+
Sbjct: 2343 RNREEEIEQLNEVIEKLQQE 2362
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/241 (22%), Positives = 106/241 (43%), Gaps = 21/241 (8%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHEL----EEERHLRLQS 87
+E L LE Q + + L + + Q+++ + + ++++++ E+ R+L LQ
Sbjct: 3242 LEDLKFSLESQKQRNLQLNLLLEQ-QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQ- 3299
Query: 88 EKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLS 147
V LESE+ RI R + R E + LQS Q + + + +E
Sbjct: 3300 ------VLLESEKVRI--REMSSTLDR-ERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3350
Query: 148 EEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLL----LERLKALEAENSALALEN 203
+ E KH +E L+ E + +S T + EK + + L+ + E E
Sbjct: 3351 QLEEKHSRIVELLNET--EKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHEL 3408
Query: 204 ENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPT 263
+++ E +R L+E QV + L + L+ + + + + E++ + IL+Q PT
Sbjct: 3409 QSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPT 3468
Query: 264 S 264
+
Sbjct: 3469 T 3469
Score = 35.8 bits (81), Expect = 0.11
Identities = 40/201 (19%), Positives = 91/201 (45%), Gaps = 22/201 (10%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSL--WREKLAVARLQREVAQ 62
+QL+ + + + S+ + + + + I QLEEQ L +++K +Q Q
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 63 RTSEGAMHEKL-IHELEEERHLRLQSEKRLQEVT----------LESERNRIQMRS-LQQ 110
EK+ ++E+E+++ + +++ +QE +E E+ ++++ L
Sbjct: 303 --------EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTT 354
Query: 111 QFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRS 170
+ E ++Q + K E N + + SEE ++ +E+L +DS+
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 171 ESSSTDEGKEKTKLLLERLKA 191
E+ +++T+ LE+L+A
Sbjct: 415 ETDIVQRMEQETQRKLEQLRA 435
Score = 33.1 bits (74), Expect = 0.73
Identities = 72/351 (20%), Positives = 141/351 (40%), Gaps = 65/351 (18%)
Query: 1 MEGKRQL---EKRDFGKRLSLDSSLVEYMDSNKYIEHL-LTQLEEQHRSLWREKLAVARL 56
M+ RQL E++ R L E+ + + + + Q+E Q + + + RL
Sbjct: 1574 MDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL 1633
Query: 57 QREVAQRTS---EGAMHEK---LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQ 110
R++AQR+S E + E+ L+ ELE + L L ++L E + Q ++ +
Sbjct: 1634 NRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKL---CCELRNSSTQTQNGNE 1690
Query: 111 QFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ--------EKLSEEERKHKEALEDL-- 160
+EE + PE E ++ Y K+ E K A+E+
Sbjct: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
Query: 161 -HM--VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEV 217
H+ ++D S+S+SS++ L+ R +A + S + E++ R DE
Sbjct: 1751 RHVLGILDRSSKSQSSAS---------LIWRSEAEASVKSCV-------HEEHTRVTDES 1794
Query: 218 ANQVVQALLTQKDLR------EECVKLKTRVF-------DLEQQNRTLSILFQQRVRPTS 264
+ + + D+ EE +L R+ +++ +N L + R++
Sbjct: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854
Query: 265 DLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKC 315
+ LL+ + + S++E + +TQ+ E + +LKC
Sbjct: 1855 EKLLEAI---------SETSSQLE-HAKVTQTELMRESFRQKQEATESLKC 1895
Score = 32.0 bits (71), Expect = 1.6
Identities = 56/243 (23%), Positives = 107/243 (44%), Gaps = 30/243 (12%)
Query: 66 EGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQS 125
+G ++ + L++ L SE +Q + + +I ++ Q+ +E + +Q
Sbjct: 3071 QGVEYQAAMECLQKADRRSLLSE--IQALHAQMNGRKITLKREQESEKPSQELLEYNIQ- 3127
Query: 126 QGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKT-KL 184
QK+ + + + V + + + +E L MVV E +SE + T E T K
Sbjct: 3128 -----QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE-LKSELAQTKLELETTLKA 3181
Query: 185 LLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKL------ 238
+ LK LE A LE +++ ++ D +A++ ++ Q L +E KL
Sbjct: 3182 QHKHLKELE----AFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER 3237
Query: 239 -KTRVFDL-------EQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERN 290
K + DL +Q+N L++L +Q+ + ++ QK+ S+ + L L E RN
Sbjct: 3238 DKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE-SQQKIESQRM-LYDAQLSEEQGRN 3295
Query: 291 RSL 293
L
Sbjct: 3296 LEL 3298
Score = 30.8 bits (68), Expect = 3.6
Identities = 76/338 (22%), Positives = 131/338 (38%), Gaps = 44/338 (13%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
I L +Q+ E H SL EK V ++ V ++ + +KL+ E E++ + ++
Sbjct: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSP 2666
Query: 92 QEV-TLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEE 150
Q+V L++ F+ +E + ++ KE+ + QE+L +E
Sbjct: 2667 QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL---QEELLVKE 2723
Query: 151 RKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQY 210
+DL V D + ++ + KE + E KA E + L +
Sbjct: 2724 TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTD 2783
Query: 211 ERCLDEVANQVVQALL----TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDL 266
+NQ Q L+ Q +L+ EC E+ +S F +++
Sbjct: 2784 GTLKISSSNQTPQILVKNAGIQINLQSEC--------SSEEVTEIIS-QFTEKIEK---- 2830
Query: 267 LLQKLH-SRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSAL-KCPGLGAVIPG 324
+Q+LH + +LD+ S + S T+ EH + + +C L AVI
Sbjct: 2831 -MQELHAAEILDMESRHI------------SETETLKREHYVAVQLLKEECGTLKAVIQ- 2876
Query: 325 HLCPRNSYSSS-SELSLS---STCSEYSSGSSYTWHDG 358
C R+ SS EL+ S T SS S W G
Sbjct: 2877 --CLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2912
Score = 30.0 bits (66), Expect = 6.2
Identities = 46/243 (18%), Positives = 99/243 (40%), Gaps = 24/243 (9%)
Query: 24 EYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHL 83
+ M+ ++ + Q E++ + ++K+ + + E QR E + +LE +R
Sbjct: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3437
Query: 84 RLQSEKRLQEVTLESER--NRIQMRSLQQ--QFSRMEETVRNLLQSQGSPEQKKEETVNI 139
+ E + QE+ E +R RI ++L + +S + RN + Q + KE
Sbjct: 3438 GIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAK 3497
Query: 140 MVYQ-----------EKLSEEERKHKEALEDLHMVVDEDSRSESSSTD------EGKEKT 182
++ E + ++ + L+ L E + E++ + E ++
Sbjct: 3498 LIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEI 3557
Query: 183 KLLLERLKALEAENSALALENENQREQYERCL---DEVANQVVQALLTQKDLREECVKLK 239
L L++L + E +L + + ER L E+ + Q + DLR +KL+
Sbjct: 3558 ILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLE 3617
Query: 240 TRV 242
++
Sbjct: 3618 EQI 3620
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/310 (26%), Positives = 136/310 (43%), Gaps = 51/310 (16%)
Query: 20 SSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEE 79
S ++E ++ T+L+EQ S EK+ VA L+ E+AQ +LE
Sbjct: 3123 SQMLEMQVELSSMKDRATELQEQLSS---EKMVVAELKSELAQT------------KLEL 3167
Query: 80 ERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNI 139
E L+ Q K L+E+ E R++++ + + +T+ + EQKK +
Sbjct: 3168 ETTLKAQ-HKHLKEL----EAFRLEVKDKTDEVHLLNDTLAS--------EQKKSRELQW 3214
Query: 140 MVYQEK--LSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENS 197
+ +EK L E + KE LEDL ++ S + + LLLE+ K L E+
Sbjct: 3215 ALEKEKAKLGRSEERDKEELEDLKFSLE--------SQKQRNLQLNLLLEQQKQLLNESQ 3266
Query: 198 ALALENENQREQYERCLDEVA--NQVVQALLTQKDLR-EECVKLKTRVFDLEQQNRTLSI 254
+ E+QR Y+ L E N +Q LL + +R E R +L Q ++
Sbjct: 3267 Q---KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323
Query: 255 LFQQRVR-PTSDLL------LQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQL 307
Q R P+ DLL L++ HSR+++L + +++ ++ Q D +VH L
Sbjct: 3324 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3383
Query: 308 NTKSALKCPG 317
T+ G
Sbjct: 3384 QTEQEANTEG 3393
Score = 53.1 bits (126), Expect = 7e-07
Identities = 67/307 (21%), Positives = 141/307 (45%), Gaps = 36/307 (11%)
Query: 28 SNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQS 87
++K + L Q+ ++++ + KL + +++ Q + E + EL++ H Q
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 88 EKRL-QEVTLESERNRIQMRSL------QQQFSRMEETVR-NLLQSQGSPEQKKEETVNI 139
E + Q + E++R Q+R+ QQ +E +R ++ Q + + K E N
Sbjct: 415 ETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENA 474
Query: 140 MVYQEKLSEEERKHK---EALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAEN 196
+ ++ E + K A+ +L++ + + + S ++ KE+ L+LE AL+ +
Sbjct: 475 LRSYSNITVNEDQIKLMNVAINELNIKLQDTN----SQKEKLKEELGLILEEKCALQRQL 530
Query: 197 SALALENENQREQYERCLDEVA------NQVVQALLTQKDLREECVKLKTRVFDLEQQNR 250
L E REQ +R +A N+ ++L T +DL+ E V +LE ++
Sbjct: 531 EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHE 590
Query: 251 TLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRS---------LTQSRTDAE 301
++ ++ +L+K + +LD + +E+ER R+ L++ + D E
Sbjct: 591 AEVTNYKIKLE-----MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE 645
Query: 302 VHEHQLN 308
+ EH++N
Sbjct: 646 I-EHRIN 651
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/252 (23%), Positives = 116/252 (46%), Gaps = 33/252 (13%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHEL------EEERHL-R 84
+E L L+E+ L+ +LQR++ +R E E + EL E+ +H
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGA 2170
Query: 85 LQSEKRLQ-EVTLESERNRI-----QMRSLQQQFSRMEETVRNLLQSQGSPE-----QKK 133
++++ L EV L++ER+ I ++ +L++Q + E + N + QKK
Sbjct: 2171 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2230
Query: 134 EETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALE 193
E T + ++L +E + K+ +E L + + E S++ ST + + ++ E
Sbjct: 2231 ESTTRL----QELEQENKLFKDDMEKLGLAIKE---SDAMSTQDQHVLFGKFAQIIQEKE 2283
Query: 194 AENSALALENENQREQYERCLD----EVANQVVQALLTQKDL---REECVKLKTRVFDLE 246
E L + ++Q + D E N++++ L TQ + +ECVK + R ++E
Sbjct: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK-RNREEEIE 2342
Query: 247 QQNRTLSILFQQ 258
Q N + L Q+
Sbjct: 2343 QLNEVIEKLQQE 2354
Score = 49.7 bits (117), Expect = 8e-06
Identities = 70/304 (23%), Positives = 134/304 (44%), Gaps = 46/304 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKL-IHELEEERHLRLQSEKR 90
+E L TQL H E+L+ + E+ R + + + L IH ++ L+ + ++
Sbjct: 622 LERLRTQLLFSHE----EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQK 677
Query: 91 LQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLS--E 148
++ + E + + L + S++++ ++L+ S+ +E T+ I Q+++
Sbjct: 678 IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS-----EEMTLQINELQKEIEILR 732
Query: 149 EERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQRE 208
+E K K LE V E + KEK L E+ LEAENS L E + +
Sbjct: 733 QEEKEKGTLEQ---EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
Query: 209 ---------QYERCL----------DEVANQVVQALLTQ-KDLREECVKLKTRVFDLEQQ 248
Q ER + D V + ++ L+ + +DL+++C++L ++E+Q
Sbjct: 790 MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNE---EIEKQ 846
Query: 249 NRTLSILFQQRVRPTSDLLLQKLHSRLL----DLSSGDLLSEVERNRSLTQSRTDAEVHE 304
T S F ++ + LQ+ ++ LL DL E+E L + E+H
Sbjct: 847 RNTFS--FAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL--KALNEELHL 902
Query: 305 HQLN 308
++N
Sbjct: 903 QRIN 906
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/241 (22%), Positives = 106/241 (43%), Gaps = 21/241 (8%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHEL----EEERHLRLQS 87
+E L LE Q + + L + + Q+++ + + ++++++ E+ R+L LQ
Sbjct: 3234 LEDLKFSLESQKQRNLQLNLLLEQ-QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQ- 3291
Query: 88 EKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLS 147
V LESE+ RI R + R E + LQS Q + + + +E
Sbjct: 3292 ------VLLESEKVRI--REMSSTLDR-ERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3342
Query: 148 EEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLL----LERLKALEAENSALALEN 203
+ E KH +E L+ E + +S T + EK + + L+ + E E
Sbjct: 3343 QLEEKHSRIVELLNET--EKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHEL 3400
Query: 204 ENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPT 263
+++ E +R L+E QV + L + L+ + + + + E++ + IL+Q PT
Sbjct: 3401 QSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPT 3460
Query: 264 S 264
+
Sbjct: 3461 T 3461
Score = 35.8 bits (81), Expect = 0.11
Identities = 40/201 (19%), Positives = 91/201 (45%), Gaps = 22/201 (10%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSL--WREKLAVARLQREVAQ 62
+QL+ + + + S+ + + + + I QLEEQ L +++K +Q Q
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 63 RTSEGAMHEKL-IHELEEERHLRLQSEKRLQEVT----------LESERNRIQMRS-LQQ 110
EK+ ++E+E+++ + +++ +QE +E E+ ++++ L
Sbjct: 303 --------EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTT 354
Query: 111 QFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRS 170
+ E ++Q + K E N + + SEE ++ +E+L +DS+
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 171 ESSSTDEGKEKTKLLLERLKA 191
E+ +++T+ LE+L+A
Sbjct: 415 ETDIVQRMEQETQRKLEQLRA 435
Score = 33.1 bits (74), Expect = 0.73
Identities = 72/351 (20%), Positives = 141/351 (40%), Gaps = 65/351 (18%)
Query: 1 MEGKRQL---EKRDFGKRLSLDSSLVEYMDSNKYIEHL-LTQLEEQHRSLWREKLAVARL 56
M+ RQL E++ R L E+ + + + + Q+E Q + + + RL
Sbjct: 1574 MDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL 1633
Query: 57 QREVAQRTS---EGAMHEK---LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQ 110
R++AQR+S E + E+ L+ ELE + L L ++L E + Q ++ +
Sbjct: 1634 NRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKL---CCELRNSSTQTQNGNE 1690
Query: 111 QFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ--------EKLSEEERKHKEALEDL-- 160
+EE + PE E ++ Y K+ E K A+E+
Sbjct: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
Query: 161 -HM--VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEV 217
H+ ++D S+S+SS++ L+ R +A + S + E++ R DE
Sbjct: 1751 RHVLGILDRSSKSQSSAS---------LIWRSEAEASVKSCV-------HEEHTRVTDES 1794
Query: 218 ANQVVQALLTQKDLR------EECVKLKTRVF-------DLEQQNRTLSILFQQRVRPTS 264
+ + + D+ EE +L R+ +++ +N L + R++
Sbjct: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854
Query: 265 DLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKC 315
+ LL+ + + S++E + +TQ+ E + +LKC
Sbjct: 1855 EKLLEAI---------SETSSQLE-HAKVTQTELMRESFRQKQEATESLKC 1895
Score = 32.0 bits (71), Expect = 1.6
Identities = 56/243 (23%), Positives = 107/243 (44%), Gaps = 30/243 (12%)
Query: 66 EGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQS 125
+G ++ + L++ L SE +Q + + +I ++ Q+ +E + +Q
Sbjct: 3063 QGVEYQAAMECLQKADRRSLLSE--IQALHAQMNGRKITLKREQESEKPSQELLEYNIQ- 3119
Query: 126 QGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKT-KL 184
QK+ + + + V + + + +E L MVV E +SE + T E T K
Sbjct: 3120 -----QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE-LKSELAQTKLELETTLKA 3173
Query: 185 LLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKL------ 238
+ LK LE A LE +++ ++ D +A++ ++ Q L +E KL
Sbjct: 3174 QHKHLKELE----AFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER 3229
Query: 239 -KTRVFDL-------EQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERN 290
K + DL +Q+N L++L +Q+ + ++ QK+ S+ + L L E RN
Sbjct: 3230 DKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE-SQQKIESQRM-LYDAQLSEEQGRN 3287
Query: 291 RSL 293
L
Sbjct: 3288 LEL 3290
Score = 30.8 bits (68), Expect = 3.6
Identities = 76/338 (22%), Positives = 131/338 (38%), Gaps = 44/338 (13%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
I L +Q+ E H SL EK V ++ V ++ + +KL+ E E++ + ++
Sbjct: 2600 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSP 2658
Query: 92 QEV-TLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEE 150
Q+V L++ F+ +E + ++ KE+ + QE+L +E
Sbjct: 2659 QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL---QEELLVKE 2715
Query: 151 RKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQY 210
+DL V D + ++ + KE + E KA E + L +
Sbjct: 2716 TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTD 2775
Query: 211 ERCLDEVANQVVQALL----TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDL 266
+NQ Q L+ Q +L+ EC E+ +S F +++
Sbjct: 2776 GTLKISSSNQTPQILVKNAGIQINLQSEC--------SSEEVTEIIS-QFTEKIEK---- 2822
Query: 267 LLQKLH-SRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSAL-KCPGLGAVIPG 324
+Q+LH + +LD+ S + S T+ EH + + +C L AVI
Sbjct: 2823 -MQELHAAEILDMESRHI------------SETETLKREHYVAVQLLKEECGTLKAVIQ- 2868
Query: 325 HLCPRNSYSSS-SELSLS---STCSEYSSGSSYTWHDG 358
C R+ SS EL+ S T SS S W G
Sbjct: 2869 --CLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2904
Score = 30.0 bits (66), Expect = 6.2
Identities = 46/243 (18%), Positives = 99/243 (40%), Gaps = 24/243 (9%)
Query: 24 EYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHL 83
+ M+ ++ + Q E++ + ++K+ + + E QR E + +LE +R
Sbjct: 3370 QQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3429
Query: 84 RLQSEKRLQEVTLESER--NRIQMRSLQQ--QFSRMEETVRNLLQSQGSPEQKKEETVNI 139
+ E + QE+ E +R RI ++L + +S + RN + Q + KE
Sbjct: 3430 GIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAK 3489
Query: 140 MVYQ-----------EKLSEEERKHKEALEDLHMVVDEDSRSESSSTD------EGKEKT 182
++ E + ++ + L+ L E + E++ + E ++
Sbjct: 3490 LIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEI 3549
Query: 183 KLLLERLKALEAENSALALENENQREQYERCL---DEVANQVVQALLTQKDLREECVKLK 239
L L++L + E +L + + ER L E+ + Q + DLR +KL+
Sbjct: 3550 ILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLE 3609
Query: 240 TRV 242
++
Sbjct: 3610 EQI 3612
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2315 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2364
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2365 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1652
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1764
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1765 EVLLASKARAEE 1776
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2529
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2588
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2589 EENQRLREQLQLLEEQHR 2606
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1377
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1432
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1433 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1545
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1546 EEAERRLRQAEVE 1558
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 1872 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 1927 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALE 2009
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2488
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2186
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2187 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2246 RI---EAENRAL 2254
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1497 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1614 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1667 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1781 TSEKSKQRLEAEA 1793
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2510 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2557
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2613
Query: 177 E 177
E
Sbjct: 2614 E 2614
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1416
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1417 SIQEELQQ-LRQSSEAEIQ 1434
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2319 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2368
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2369 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2425
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1656
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1713
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1768
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1769 EVLLASKARAEE 1780
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2479 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2533
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2592
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2593 EENQRLREQLQLLEEQHR 2610
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1323 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1381
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1382 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1436
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1437 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1549
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1550 EEAERRLRQAEVE 1562
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1817
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1818 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1875
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 1876 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 1931 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALE 2013
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2492
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2493 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2552
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2190
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2191 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2250 RI---EAENRAL 2258
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1501 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1557
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1618 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1671 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1724
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1785 TSEKSKQRLEAEA 1797
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2458 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2513
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2514 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2561
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2617
Query: 177 E 177
E
Sbjct: 2618 E 2618
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1241 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1300
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1360
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1420
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1421 SIQEELQQ-LRQSSEAEIQ 1438
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2315 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2364
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2365 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1652
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1764
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1765 EVLLASKARAEE 1776
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2529
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2588
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2589 EENQRLREQLQLLEEQHR 2606
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1377
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1432
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1433 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1545
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1546 EEAERRLRQAEVE 1558
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 1872 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 1927 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALE 2009
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2488
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2186
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2187 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2246 RI---EAENRAL 2254
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1497 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1614 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1667 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1781 TSEKSKQRLEAEA 1793
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2510 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2557
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2613
Query: 177 E 177
E
Sbjct: 2614 E 2614
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1416
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1417 SIQEELQQ-LRQSSEAEIQ 1434
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2283 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2332
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2333 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2389
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1620
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1677
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1732
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1733 EVLLASKARAEE 1744
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2443 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2497
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2556
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2557 EENQRLREQLQLLEEQHR 2574
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1287 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1345
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1346 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1400
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1401 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1513
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1514 EEAERRLRQAEVE 1526
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1781
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1782 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1839
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 1840 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 1895 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALE 1977
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2456
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2457 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2516
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2154
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2155 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2214 RI---EAENRAL 2222
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1465 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1521
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1582 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1635 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1688
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1749 TSEKSKQRLEAEA 1761
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2422 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2477
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2478 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2525
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2581
Query: 177 E 177
E
Sbjct: 2582 E 2582
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1205 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1264
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1324
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1384
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1385 SIQEELQQ-LRQSSEAEIQ 1402
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2452 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2501
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2502 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2558
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1789
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1846
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1901
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1902 EVLLASKARAEE 1913
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2612 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2666
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2725
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2726 EENQRLREQLQLLEEQHR 2743
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1456 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1514
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1515 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1569
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1570 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1682
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1683 EEAERRLRQAEVE 1695
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1950
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1951 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 2008
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 2009 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 2064 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALE 2146
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2625
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2323
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2324 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2383 RI---EAENRAL 2391
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1634 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1690
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1751 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1804 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1857
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1918 TSEKSKQRLEAEA 1930
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2591 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2646
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2647 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2694
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2750
Query: 177 E 177
E
Sbjct: 2751 E 2751
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1374 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1433
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1553
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1554 SIQEELQQ-LRQSSEAEIQ 1571
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2293 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2342
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2343 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2399
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1630
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1631 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1687
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1742
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1743 EVLLASKARAEE 1754
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2452
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2453 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2507
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2508 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2566
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2567 EENQRLREQLQLLEEQHR 2584
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1297 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1355
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1356 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1410
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1411 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1523
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1524 EEAERRLRQAEVE 1536
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1791
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1792 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1849
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 1850 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 1905 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALE 1987
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2466
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2164
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2165 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2224 RI---EAENRAL 2232
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1475 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1531
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1592 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1645 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1698
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1759 TSEKSKQRLEAEA 1771
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2432 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2487
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2488 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2535
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2591
Query: 177 E 177
E
Sbjct: 2592 E 2592
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1394
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1395 SIQEELQQ-LRQSSEAEIQ 1412
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2301 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2350
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2351 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2407
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1638
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1639 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1695
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1750
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1751 EVLLASKARAEE 1762
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2460
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2461 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2515
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2574
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2575 EENQRLREQLQLLEEQHR 2592
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1305 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1363
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1364 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1418
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1419 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1531
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1532 EEAERRLRQAEVE 1544
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1799
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1800 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1857
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 1858 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 1913 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALE 1995
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2474
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2475 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2534
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2535 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2056
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2172
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2173 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2232 RI---EAENRAL 2240
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1483 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1539
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1599
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1600 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1653 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1706
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1767 TSEKSKQRLEAEA 1779
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2440 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2495
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2496 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2543
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2599
Query: 177 E 177
E
Sbjct: 2600 E 2600
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1223 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1282
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1402
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1403 SIQEELQQ-LRQSSEAEIQ 1420
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/358 (20%), Positives = 145/358 (40%), Gaps = 25/358 (6%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
++ L + E R+ + A + +RE AQ + E+L EE+ R Q++
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162
Query: 92 QEVTLESER--------NRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQ 143
+++ E+E+ + +R Q + ME+ + Q+ Q ++E + +
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
Query: 144 EKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL----EAENSAL 199
E+ ++ E L+ L E +R + S +E ++ +E L L EAEN AL
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 200 ALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRV-FDLEQQNRTLSILFQQ 258
L +++ +++ + E QV + +E +L+ DL QQ + ++
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
Query: 259 RVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGL 318
+++ + K + LL + ++ + Q+R E E Q+ + A + G
Sbjct: 2342 KMQAVQEATRLKAEAELL---------QQQKELAQEQARRLQEDKE-QMAQQLAEETQGF 2391
Query: 319 GAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKEANENLQEDE 376
+ + S+ +E L +E S + D + RK+ +E E L E
Sbjct: 2392 QRTLEAERQRQLEMSAEAE-RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2448
Score = 51.6 bits (122), Expect = 2e-06
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 44 RSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNR 102
RSL E +AVA+L+ E +R + A E+ E E E +L++ + L+ + L++E
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVA 1679
Query: 103 IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHM 162
Q Q + + +E + +G E E+ V E+ E++R+ E +
Sbjct: 1680 QQKSLAQAEAEKQKEEAEREARRRGKAE---EQAVRQRELAEQELEKQRQLAEGTAQQRL 1736
Query: 163 VVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVV 222
+++ + T++G+++ +LL E L L+ E +A +R++ E L +V + +
Sbjct: 1737 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----QKRQELEAELAKVRAE-M 1791
Query: 223 QALLTQKDLREE 234
+ LL K EE
Sbjct: 1792 EVLLASKARAEE 1803
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/258 (22%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 5 RQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQ-- 62
+QL + G + +L++ ++ + E L ++ E R+ R + R +++ +
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441
Query: 63 ---RTSEGAMHEK--LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRS---LQQQFSR 114
+E A EK L+ LE +R +RL+E E ER + +++ L Q S
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2501
Query: 115 MEETVRN--LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSES 172
+TV+ LLQ + +Q + ++ +E+ E+E K LE L DE ++++
Sbjct: 2502 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE---KAKLEQLFQ--DEVAKAQQ 2556
Query: 173 SSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR 232
++ +++ ++ ER + + + A ++E + E R +E+ Q ++ L
Sbjct: 2557 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQRRQQEELLA 2615
Query: 233 EECVKLKTRVFDLEQQNR 250
EE +L+ ++ LE+Q+R
Sbjct: 2616 EENQRLREQLQLLEEQHR 2633
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 56 LQREVAQRTSEGAMHEKLIHE----LEEERHL----RLQSEKRLQEVTLESERNRIQMRS 107
L+ ++ T+ + + K I E +EEE L R + +RL EV E+ R Q+
Sbjct: 1346 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAE 1404
Query: 108 LQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDED 167
Q E LQ + E + E + Q+K R +E L+ L + +
Sbjct: 1405 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-----RSIQEELQQLRQSSEAE 1459
Query: 168 SRSESSSTDEGKEKTKLLLERLKALEAENSALALE-NENQREQYERCLDEVANQVVQALL 226
++++ E E+++L +E E L LE E QR E L + + +A
Sbjct: 1460 IQAKARQA-EAAERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSE 286
++ +EE +L+ +V D Q+ R + RV+ ++ +K R L L
Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1572
Query: 287 VERNRSLTQSRTD 299
E R L Q+ +
Sbjct: 1573 EEAERRLRQAEVE 1585
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/324 (23%), Positives = 127/324 (39%), Gaps = 18/324 (5%)
Query: 1 MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
+E +RQL + +RL+ + L+ + E LEE+ L RE A + ++E+
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 61 AQRTSE--GAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
++ M L + E R SEK Q + E+ R R + + EE
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1840
Query: 119 VRNLLQSQGSPEQKKEETVNIMVYQEKLS---EEERKHKEALEDLHMVVDEDSRSESSST 175
R ++ +++ E ++ EKL+ E R EA L E+ R +
Sbjct: 1841 KRQRQLAEEDAARQRAEAERVLA--EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1898
Query: 176 DEGKEKTKLLLERLKALEAENSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREE 234
DE ++ RL+ A++ A E Q R+ + L+ V L ++ + EE
Sbjct: 1899 DEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTS-DLLLQKLHSRLLDLSSGDLLSEVERNRSL 293
+ LK F+ + L R+R + D L K + L L +E ER R
Sbjct: 1954 ILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012
Query: 294 TQSRTD---AEVHEHQLNTKSALK 314
+ R A E K+AL+
Sbjct: 2013 AEERVQKSLAAEEEAARQRKAALE 2036
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 23/231 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSN--KYIEHLLTQLEEQHRSLWREKLA------- 52
E +RQLE +RL L + + + + + Q EE L R +LA
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 53 VARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQF 112
V L+ + Q + + I ELE E+ +LQ E +L ++ E E +Q L Q+
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSE-EMQTVQQEQLLQET 2515
Query: 113 SRMEETVRN----LLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLH--- 161
++++ + LLQ + EQ+K + + + ++L EE+++ ++ +E
Sbjct: 2516 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575
Query: 162 MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL-ALENENQREQYE 211
+ E++R +EG + + L++L+ + L A EN+ REQ +
Sbjct: 2576 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/252 (22%), Positives = 106/252 (42%), Gaps = 39/252 (15%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVAR---LQREVAQRT--SEGAMHEKLIHELEEERHLRLQ 86
+E L ++EE R R + AR L +E AQ+ +E H + + E+E LQ
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097
Query: 87 SEKRL------------------QEVTLESERNRIQMRSLQQQFSRM----EETVRNLLQ 124
E+ + +E +++ER Q R ++ R+ EE + Q
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157
Query: 125 SQGSPEQKKEETVNIMVYQEKLSEEERKHKEALE---DLHMVVDEDSRSESSSTDEGKEK 181
+Q + E+ ++E + + + + K+A + + H E + + + ++
Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---- 2213
Query: 182 TKLLLERLKALEAENSALALENENQREQYERC-LDEVANQVVQALLTQKDLREECVKLKT 240
+L RL+ E ++ L+ E QR + E +QV + L + + EE KLK
Sbjct: 2214 -ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 241 RVFDLEQQNRTL 252
R+ E +NR L
Sbjct: 2273 RI---EAENRAL 2281
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/313 (20%), Positives = 129/313 (41%), Gaps = 50/313 (15%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
E L Q++++ + R++ A L V ++ + LEE R ++E+RL+
Sbjct: 1524 ERLRRQVQDESQ---RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1580
Query: 93 EVTLE---------------------------SERNRIQMRSLQQQ---FSRMEETVRNL 122
+ +E +E+ RSLQ++ +++ E
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
Query: 123 LQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEG-KEK 181
Q Q E+ +EE + +L + K EAL L + +E ++ +S + E K+K
Sbjct: 1641 AQQQAEAERAREEA------ERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 182 TKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQK-DLREECVKLKT 240
+ E + +AE A+ QRE E+ L E Q+ + Q+ +E ++L+
Sbjct: 1694 EEAEREARRRGKAEEQAV-----RQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRA 1747
Query: 241 RVFDLEQQNRTL--SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRT 298
EQQ + L + QR + Q+L + L + + + + R+ +SR+
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 299 DAEVHEHQLNTKS 311
+E + +L ++
Sbjct: 1808 TSEKSKQRLEAEA 1820
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 25/181 (13%)
Query: 2 EGKRQLEK-RDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV 60
E +R+ EK + K L L S ++ + E LL + + +S EK ++ + +R +
Sbjct: 2481 ELEREKEKLQQEAKLLQLKSEEMQTVQQ----EQLLQETQALQQSFLSEKDSLLQRERFI 2536
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
Q E A E+L + E + +L+ E++ Q+ +E ER R+ + MEE R
Sbjct: 2537 EQ---EKAKLEQLFQD-EVAKAQQLREEQQRQQQQMEQERQRL--------VASMEEARR 2584
Query: 121 NLLQSQGSPEQKKEETVNI----MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTD 176
+++ +K+EE + +E L+EE ++ +E L+ +++E R+ + ++
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ----LLEEQHRAALAHSE 2640
Query: 177 E 177
E
Sbjct: 2641 E 2641
Score = 33.5 bits (75), Expect = 0.56
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 37/259 (14%)
Query: 47 WREKLA--VARLQREVAQRTSEGAMHEKLIHELEEERHLR------LQSEKRLQEVT--- 95
WRE++A + R Q +AQ E+L +L R LQ +R QE
Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263
Query: 96 --LESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK----KEETVNIMVYQEKLSE- 148
+S+ R Q+R Q +E + + Q +Q K+ + ++ Y+ +L
Sbjct: 1264 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1323
Query: 149 -EERKHKEALEDLHMVVDE--DSRSESSS-TDEGKEKTKLLLERLKALEAENSALALENE 204
K + V+ E D R+ S T + K + E L+ +E E +
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
Query: 205 NQREQY---------ERCLDEVANQVV-----QALLTQKDLREECVKLKTRVFDLEQQNR 250
+RE+ +R L E Q +A Q+ ++EE V+ + D +QQ R
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1443
Query: 251 TLSILFQQRVRPTSDLLLQ 269
++ QQ +R +S+ +Q
Sbjct: 1444 SIQEELQQ-LRQSSEAEIQ 1461
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/208 (24%), Positives = 93/208 (44%), Gaps = 26/208 (12%)
Query: 27 DSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQ 86
+ K IE Q++E+ E+LA + +++ A + E E R + +
Sbjct: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV----------EARRKQEE 643
Query: 87 SEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKL 146
+RL+ + E E R Q LQ++ +E +R +++ EQ+++E +++
Sbjct: 644 EARRLRWLQQEEEERRHQ-ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
Query: 147 SEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQ 206
E+ER+ +E E + +++ R E +E L ER KAL Q
Sbjct: 703 REQERREQERREQERQLAEQERRREQERLQAERE----LQEREKALRL-----------Q 747
Query: 207 REQYERCLDEVANQVVQALLTQKDLREE 234
+EQ +R L+E + Q L ++ L+EE
Sbjct: 748 KEQLQRELEEKKKKEEQQRLAERQLQEE 775
Score = 43.1 bits (100), Expect = 7e-04
Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 4/139 (2%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
+ LL + +E+ + R+ RL + Q E E+ E E R + E++L
Sbjct: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
Query: 93 EVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERK 152
E E+ R+Q Q+ + + LQ + ++KKEE + Q + E+E+K
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ-EEQEKK 779
Query: 153 HKEAL---EDLHMVVDEDS 168
KEA + L++ VD S
Sbjct: 780 AKEAAGASKALNVTVDVQS 798
Score = 34.7 bits (78), Expect = 0.25
Identities = 57/276 (20%), Positives = 100/276 (36%), Gaps = 37/276 (13%)
Query: 58 REVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLES------------------E 99
RE Q +++ + EL+EE+HL + + + T S +
Sbjct: 441 REPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQ 500
Query: 100 RNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALED 159
RN++ M S M+ ++ + P+ V +E+ E + KE E
Sbjct: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCS-------FVEKERQRLENLRRKEEAEQ 553
Query: 160 L-HMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVA 218
L V+ED R +E K K + L ++ + E + Q EQ +DE
Sbjct: 554 LRRQKVEEDKRRR---LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
Query: 219 NQVVQALLTQKDLREECVKLKTRVFDL----EQQNRTLSILFQQRVRPTSDLLLQKL--- 271
+ + L ++ +++ K + E++ R L L Q+ LLQK
Sbjct: 611 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE 670
Query: 272 -HSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQ 306
RL + L+E Q R + E E +
Sbjct: 671 EQERLRKAAEAKRLAEQREQERREQERREQERREQE 706
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/208 (24%), Positives = 93/208 (44%), Gaps = 26/208 (12%)
Query: 27 DSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQ 86
+ K IE Q++E+ E+LA + +++ A + E E R + +
Sbjct: 590 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV----------EARRKQEE 639
Query: 87 SEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKL 146
+RL+ + E E R Q LQ++ +E +R +++ EQ+++E +++
Sbjct: 640 EARRLRWLQQEEEERRHQ-ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 698
Query: 147 SEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQ 206
E+ER+ +E E + +++ R E +E L ER KAL Q
Sbjct: 699 REQERREQERREQERQLAEQERRREQERLQAERE----LQEREKALRL-----------Q 743
Query: 207 REQYERCLDEVANQVVQALLTQKDLREE 234
+EQ +R L+E + Q L ++ L+EE
Sbjct: 744 KEQLQRELEEKKKKEEQQRLAERQLQEE 771
Score = 43.1 bits (100), Expect = 7e-04
Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 4/139 (2%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ 92
+ LL + +E+ + R+ RL + Q E E+ E E R + E++L
Sbjct: 657 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716
Query: 93 EVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERK 152
E E+ R+Q Q+ + + LQ + ++KKEE + Q + E+E+K
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ-EEQEKK 775
Query: 153 HKEAL---EDLHMVVDEDS 168
KEA + L++ VD S
Sbjct: 776 AKEAAGASKALNVTVDVQS 794
Score = 37.4 bits (85), Expect = 0.039
Identities = 55/275 (20%), Positives = 102/275 (37%), Gaps = 39/275 (14%)
Query: 58 REVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLES------------------E 99
RE Q +++ + EL+EE+HL + + + T S +
Sbjct: 441 REPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQ 500
Query: 100 RNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALED 159
RN++ M S M+ ++ + P++K+ + + E R+ +EA +
Sbjct: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL----------ENLRRKEEAEQL 550
Query: 160 LHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVAN 219
V+ED R +E K K + L ++ + E + Q EQ +DE
Sbjct: 551 RRQKVEEDKRRR---LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 607
Query: 220 QVVQALLTQKDLREECVKLKTRVFDL----EQQNRTLSILFQQRVRPTSDLLLQKL---- 271
+ + L ++ +++ K + E++ R L L Q+ LLQK
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 667
Query: 272 HSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQ 306
RL + L+E Q R + E E +
Sbjct: 668 QERLRKAAEAKRLAEQREQERREQERREQERREQE 702
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 56.6 bits (135), Expect = 6e-08
Identities = 65/289 (22%), Positives = 140/289 (48%), Gaps = 30/289 (10%)
Query: 18 LDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHEL 77
LD + Y+ + L+ ++E+ + L ++ ++RL+ ++ + E+L+ +L
Sbjct: 2489 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ-------EQLVSKL 2541
Query: 78 ---EEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKE 134
E E L + L+ +T+E E+ +++ LQ + + +++T+ L S + E + E
Sbjct: 2542 SQVEGEHQLWKEQNLELRNLTVELEQ---KIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Query: 135 ET-VNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE---KTKLLLERLK 190
T ++ M + EK+++ K E ++H + + + + + E + +LLLE +K
Sbjct: 2599 LTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIK 2658
Query: 191 ALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNR 250
+ + + L LEN + ++ LD + V+ + +REE + + R+ + E++++
Sbjct: 2659 SSKDQLKELTLEN----SELKKSLDCMHKDQVE---KEGKVREEIAEYQLRLHEAEKKHQ 2711
Query: 251 TLSILFQQRVRPTSDLLLQKLHSRLLDLSSG----DLL--SEVERNRSL 293
L + ++ +KL S+ LSS DLL S+ E N SL
Sbjct: 2712 ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSL 2760
Score = 54.3 bits (129), Expect = 3e-07
Identities = 69/306 (22%), Positives = 136/306 (44%), Gaps = 29/306 (9%)
Query: 15 RLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLI 74
R + + + +E +S +E L ++E +SL +L V ++ E T+E ++ I
Sbjct: 2349 RTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERI 2408
Query: 75 HELE--EERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK 132
ELE + EK ++V ++ E++ M LQ Q + E V L Q + + K
Sbjct: 2409 SELEIINSSFENILQEKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467
Query: 133 KEETVNIMVYQEKLSEEERKHKEALEDL---HMVVDEDSRSESSSTDEGKEKTKLLLERL 189
++ N+ E L E+ + + L++ ++V+ ++GK+K L
Sbjct: 2468 EQ---NLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQK-------L 2517
Query: 190 KALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQN 249
+ + E S L + ++Q EQ L +V + +LR V+L+ ++ L+ +N
Sbjct: 2518 EKKDEEISRLKNQIQDQ-EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKN 2576
Query: 250 RTLSILFQQRVRPTSDLLLQKLHSRL---LDLSSGDLLSEVERNRSLTQSRTDAEVHEHQ 306
+L + +LQ + L L+L+ D +S VE+ +T T+ + H+
Sbjct: 2577 ASLQDTLE---------VLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHE 2627
Query: 307 LNTKSA 312
+ K+A
Sbjct: 2628 MAQKTA 2633
Score = 48.9 bits (115), Expect = 1e-05
Identities = 61/279 (21%), Positives = 114/279 (40%), Gaps = 22/279 (7%)
Query: 22 LVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEE-- 79
+++ +S +E L TQ+EE RSL +L + L+ E T + + + EL++
Sbjct: 2174 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLL 2233
Query: 80 ERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQG---SPEQKKEET 136
L EK E+ ++ E ++ + LQ Q + E V L Q + EQ +
Sbjct: 2234 SSFKSLLEEKEQAEIQIKEE-SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPP 2292
Query: 137 VNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAEN 196
+ E+ R EA E + V + + D K + + L L+
Sbjct: 2293 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352
Query: 197 SALALENENQREQYE----------RCLDEVANQVVQALLTQKDLREECVKLKTRVFDLE 246
ALE EN + + E + L + VV +++L E K + R+ +LE
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412
Query: 247 QQNRTLSILFQQR------VRPTSDLLLQKLHSRLLDLS 279
N + + Q++ ++ S ++ L ++L +L+
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/295 (20%), Positives = 117/295 (39%), Gaps = 51/295 (17%)
Query: 17 SLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAM----HEK 72
+L S + E + +++ L LE+ ++L L L+ ++AQ E + E
Sbjct: 2018 TLSSDVSELLKDKTHLQEKLQSLEKDSQAL---SLTKCELENQIAQLNKEKELLVKESES 2074
Query: 73 LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK 132
L L E + +L K L+ +E +++ S Q++ ++ + L + E+K
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134
Query: 133 KEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKAL 192
+ + EKL E ER++ D K+K + L L+
Sbjct: 2135 Q------LHIAEKLKEREREN----------------------DSLKDKVENLERELQMS 2166
Query: 193 EAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTL 252
E + L+ EN + + E + Q+ + + K + V L++ E++N T
Sbjct: 2167 EENQELVILDAENSKAEVE----TLKTQIEEMARSLKVFELDLVTLRS-----EKENLTK 2217
Query: 253 SILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQL 307
I +Q D LL S L + ++ + E S+T E+ ++QL
Sbjct: 2218 QIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE-------SKTAVEMLQNQL 2265
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/243 (19%), Positives = 115/243 (47%), Gaps = 15/243 (6%)
Query: 29 NKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMH--EKLIHELEEERHLRLQ 86
N HLL QL+ Q++ L R K+ L+ + ++ +G ++ ++L +LE+ + ++
Sbjct: 273 NSSSPHLLDQLKAQNQEL-RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIE 331
Query: 87 SEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKL 146
EK L + E R Q +++ +E+ ++ L + Q E + ++K+
Sbjct: 332 KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSL--EQKI 389
Query: 147 SEEERKHKEAL---EDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALEN 203
E+E++ +E L + +D++ + + ++ K + L+A + +++ +
Sbjct: 390 KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 204 ENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPT 263
EN E++++ L A Q QA +++ +L+ + +++++N L +Q+ R
Sbjct: 450 ENNLEEFKQKLCR-AEQAFQASQIKEN------ELRRSMEEMKKENNLLKSHSEQKAREV 502
Query: 264 SDL 266
L
Sbjct: 503 CHL 505
Score = 42.0 bits (97), Expect = 0.002
Identities = 73/337 (21%), Positives = 140/337 (41%), Gaps = 73/337 (21%)
Query: 36 LTQLEEQ---HRSLWREKL-AVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
+++L+E H+++ E L A+ ++E+ + + I EL++ HL E L
Sbjct: 885 ISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLL---EDSL 941
Query: 92 QEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEER 151
+E+ L SE ++ + + S + + L Q G+ ++ +N + QEK++ ++
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKE-----INASLNQEKMNLIQK 996
Query: 152 KHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLER--------------LKALEAENS 197
E +DE +S S +D+ K++ +LL+R KA + +NS
Sbjct: 997 S-----ESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNS 1051
Query: 198 AL-ALEN------ENQREQYERCLDEVA------------------NQVVQALLTQKDLR 232
L L N EN++ + E+ + A N +++ Q+ LR
Sbjct: 1052 KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR 1111
Query: 233 EECV----KLKTRVFDLEQQNRTLSILFQQRVRPTSDLL--------LQKLHSRLLDLSS 280
E K+ L+Q+ TL + + +DLL + K +L S
Sbjct: 1112 SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES 1171
Query: 281 GDLLSEV-----ERNRSLTQSRTDAEVHEHQLNTKSA 312
+ + V ERN+ + + D EV E L++ +A
Sbjct: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNA 1208
Score = 38.9 bits (89), Expect = 0.013
Identities = 44/170 (25%), Positives = 85/170 (50%), Gaps = 10/170 (5%)
Query: 26 MDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMH--EKLIHELEEERHL 83
+D+NK E + E+ S E L+ +L+ ++ + + E + + LEE +
Sbjct: 2715 LDTNKQYEVEIQTYREKLTSK-EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKT 2773
Query: 84 RLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQ---SQGSPEQKKEETVNIM 140
++ + K + ++ E+ER + +M+ L + ++EE + +LQ SQ Q+K++T +M
Sbjct: 2774 KMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEE-KEILQKELSQLQAAQEKQKTGTVM 2832
Query: 141 -VYQEKLSEEERKHKEALEDLHMVVDE--DSRSESSSTDEGKEKTKLLLE 187
++L+ E ++ KE LE+ DE D + E EK K +LE
Sbjct: 2833 DTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882
Score = 35.4 bits (80), Expect = 0.15
Identities = 35/184 (19%), Positives = 84/184 (45%), Gaps = 17/184 (9%)
Query: 76 ELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEE--TVRNLLQSQGSPEQKK 133
EL+ + QS+ +E+ ++ +R LQ++ ++ E T+ L + E+++
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 134 EETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLER---LK 190
+ + L ++ H E L D +++S++ S+ + K++ + L E
Sbjct: 568 D-------CSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFS 620
Query: 191 ALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNR 250
++EN L + E+++E L N + L TQ+ ++ + R +++++N
Sbjct: 621 CWKSENEKLLTQMESEKEN----LQSKINHLETCLKTQQ-IKSHEYNERVRTLEMDRENL 675
Query: 251 TLSI 254
++ I
Sbjct: 676 SVEI 679
Score = 31.6 bits (70), Expect = 2.1
Identities = 48/193 (24%), Positives = 78/193 (40%), Gaps = 38/193 (19%)
Query: 47 WREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQS-EKRLQEVTLESERNRIQM 105
W+E L LQ+ + EG + +KL E +++R +L S E LQ+ + E + +
Sbjct: 8 WKEGLPTRALQKI---QELEGQL-DKLKKE-KQQRQFQLDSLEAALQKQKQKVENEKTEG 62
Query: 106 RSLQQQFSRMEETVRNLLQSQGSPE---QKKEETVNIMVYQ--------EKLSEEERKHK 154
+L+++ R+ E +L +++ Q KE VN Q EKL +E ++ K
Sbjct: 63 TNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 155 EALEDLHMVVDEDSRS---------------------ESSSTDEGKEKTKLLLERLKALE 193
LE S S ++ KEK +E K LE
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Query: 194 AENSALALENENQ 206
AE AL + +Q
Sbjct: 183 AEVKALQAKKASQ 195
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 56.6 bits (135), Expect = 6e-08
Identities = 93/396 (23%), Positives = 172/396 (43%), Gaps = 73/396 (18%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVA 61
+ + QL K D SS E M+ K I+H L + EE ++ LQ ++
Sbjct: 127 QSEEQLSKHD-------KSSTEEEMEIEK-IKHKLQEKEE----------LISTLQAQLT 168
Query: 62 QRTSEGAMHEKLIHELEEERHLRLQSEKRLQEV-TLESERNRIQMRSLQQQF-----SRM 115
Q +E E+EE ++ Q +++ + + TL+++ ++ Q QQ +R
Sbjct: 169 QAQAEQPAQSST--EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226
Query: 116 EETVR----NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSE 171
E VR LLQ + + E + V Q KL E H+E+L VVD +
Sbjct: 227 ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEE----HEESLVGRAQVVDLLQQEL 282
Query: 172 SSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDL 231
+++ +++ ++L ++L+ +EAE++ L E +RE+ + L+++ +V + L+ +L
Sbjct: 283 TAA----EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338
Query: 232 REEC--------------VKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLD 277
+EE +L++R LEQ+++ + + + L LQK L
Sbjct: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA-----EMEEKTSHILSLQKTGQEL-- 391
Query: 278 LSSGDLLSE------VERNRSLTQSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNS 331
S+ D L + ++N QS + E QL KS L + P
Sbjct: 392 QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL------PLQQ 445
Query: 332 YSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVKE 367
+ ++S+ S +E + T + +L+KRV E
Sbjct: 446 HETASQTSFPDVYNE--GTQAVTEENIASLQKRVVE 479
Score = 54.3 bits (129), Expect = 3e-07
Identities = 65/281 (23%), Positives = 123/281 (43%), Gaps = 20/281 (7%)
Query: 41 EQHRSLWREKLAV-ARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESE 99
E + +W K +LQ++V T +G +++L+ +LEE RHL S+ L ++ E +
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKVCD-TLQGE-NKELLSQLEETRHLYHSSQNELAKLESELK 2315
Query: 100 RNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALED 159
+ Q+ L + +E NL +G Q++ + N E+L + + +E
Sbjct: 2316 SLKDQLTDLSNSLEKCKEQKGNL---EGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372
Query: 160 LHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVAN 219
LH ++ + S +E ++ + L+ + + LEN +E+ E + E N
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQ-QHDKEIKELENLLSQEEEENIVLEEEN 2431
Query: 220 QVV-----QALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSR 274
+ Q + T K +++E ++ K + L+ +++S L R R D Q+L R
Sbjct: 2432 KKAVDKTNQLMETLKTIKKENIQQKAQ---LDSFVKSMSSLQNDRDRIVGD--YQQLEER 2486
Query: 275 LLD--LSSGDLLSE-VERNRSLTQSRTDAEVHEHQLNTKSA 312
L L L+ E N L + H LN+++A
Sbjct: 2487 HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENA 2527
Score = 51.2 bits (121), Expect = 3e-06
Identities = 75/379 (19%), Positives = 145/379 (38%), Gaps = 42/379 (11%)
Query: 24 EYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHL 83
+ + ++ + HL +QLE+ + + A+A LQ E +E EK E ++
Sbjct: 2809 QLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE---LEKFRKSEEGKQRS 2865
Query: 84 RLQSEKRLQEV--------TLESERNRI--QMRSLQQQFSRMEETVRNLLQSQGSPEQKK 133
Q EV +L+++R+R+ ++++LQQQ+ ++ + + L + ++ +
Sbjct: 2866 AAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQ 2925
Query: 134 EETVNIMVYQEKLSEEERKHKEALEDLHMV----------VDEDSRSESSSTDEGKEKTK 183
++T + QE+L +E + L L M + E S D+ +
Sbjct: 2926 DKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQ 2985
Query: 184 LLLERLKALEAENSALALENENQRE-QYERCLDEVANQVVQALLTQKDLREECVKLKTRV 242
L+ L++ ++ L ++ + Q + D N V + L + L + ++ +
Sbjct: 2986 NLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKE 3045
Query: 243 FDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEV 302
++Q N S L +++ + L R GDLL N + E+
Sbjct: 3046 LRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLL-----NHCAVLEKQVQEL 3100
Query: 303 HEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLR 362
LN V PG +N S+ E S N R
Sbjct: 3101 QAGPLNID----------VAPGAPQEKNGVHRKSD---PEELREPQQSFSEAQQQLCNTR 3147
Query: 363 KRVKEANENLQEDEDDAVA 381
+ V E + L+E+ D VA
Sbjct: 3148 QEVNELRKLLEEERDQRVA 3166
Score = 48.9 bits (115), Expect = 1e-05
Identities = 97/457 (21%), Positives = 175/457 (38%), Gaps = 72/457 (15%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDS--------------NKYIEHLLTQLEEQHRSLW 47
E K LE+R + L+ S+ Y K ++ +++LEE+ + L
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV 1976
Query: 48 REKLAV-ARLQREV------AQRTSEGAMHEKLIHELEEERH----------LRLQSE-- 88
+EK V + +++E AQ+ H K + EL +E+ +R Q +
Sbjct: 1977 KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKIS 2036
Query: 89 ------KRLQEVTLESERN-RIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMV 141
K L+ V ES+++ I +L Q ++ L + + + E ++
Sbjct: 2037 ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA 2096
Query: 142 YQEKLSEEERKHKEALEDLHMVVDED--SRSESSSTDEGKEKTKLLLERLKALEAENSAL 199
KL +E + +KE+++ DED R E + KEK K + E+L AL E L
Sbjct: 2097 DNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK-KNMQEKLDALRREKVHL 2155
Query: 200 ----------ALENENQREQYERCLDEVANQVVQALLTQKDLR-------EECVKLKTRV 242
+ + + +Q + LD Q+ + L+ +E K + +
Sbjct: 2156 EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKF 2215
Query: 243 FDLEQQNRTLSILFQQRVRPTSDLLLQ-KLHSRLLDLSSGDLLSEVERNRSLTQSRTDAE 301
D Q L + D L Q +H L ++ +S +E ++ + +S+ E
Sbjct: 2216 SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKIN----ISRLEHDKQIWESKAQTE 2271
Query: 302 VHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNL 361
V QL K G + L SS+ L+ SE S D N
Sbjct: 2272 V---QLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL-TDLSNS 2327
Query: 362 RKRVKEANENLQ---EDEDDAVADSVFQSHIIESNCQ 395
++ KE NL+ ++ + +S F +E++ Q
Sbjct: 2328 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364
Score = 48.5 bits (114), Expect = 2e-05
Identities = 68/293 (23%), Positives = 130/293 (44%), Gaps = 41/293 (13%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQR-TSEGAMHEKLIHELEEERHLR--LQSEK 89
EH +LEE+ +L +EK +LQ+++ + TS A+ +K E+ERHLR L+ +K
Sbjct: 1156 EHWKPELEEKILALEKEK---EQLQKKLQEALTSRKAILKKA---QEKERHLREELKQQK 1209
Query: 90 ----RLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEK 145
RLQE E + ++ Q +++ VR + + ++E + +E
Sbjct: 1210 DDYNRLQEQFDEQSKEN---ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
Query: 146 LSEE-ERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENE 204
L + E+ H + + + ++ D S SE +S +G + +LK +EAE L L+
Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326
Query: 205 NQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTS 264
+ + + +EV +Q + ++ L E +K + ++ ++
Sbjct: 1327 STTSELTKKSEEVFQ--LQEQINKQGLEIESLKTVSHEAEVHAES--------------- 1369
Query: 265 DLLLQKLHSRLLDLSSGDLLSEV-----ERNRSLTQSRTDAEVHEHQLNTKSA 312
L QKL S L ++ + L E+ E + +++ D QL+ K A
Sbjct: 1370 --LQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEA 1420
Score = 45.8 bits (107), Expect = 1e-04
Identities = 54/318 (16%), Positives = 136/318 (42%), Gaps = 44/318 (13%)
Query: 24 EYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-RH 82
E ++ + + H+ +++EE ++L +++L + ++ + + ++ + ++ I E +++
Sbjct: 846 EVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTE 905
Query: 83 LRLQSEKRLQEVTLESERNRIQMRSLQQQF---SRMEETVRNLLQSQGSPEQKKEETVNI 139
+ +++ ++ E +++++L++Q SR EE + ++ ++ +
Sbjct: 906 ISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE 965
Query: 140 MVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSAL 199
M ++S+EE +H+ L + +++ K LL+R+ LE E + L
Sbjct: 966 MSPAGQISKEELQHEFDL------LKKENEQRKRKLQAALINRKELLQRVSRLEEELANL 1019
Query: 200 ALENENQ-----------------REQYERCLDEVANQV------------VQALLTQKD 230
E++ + +E E+C+ ++ V+ +KD
Sbjct: 1020 KDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079
Query: 231 LREECVKLKTRVFDLEQQNRTLS-----ILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLS 285
L E+ + ++Q N+TL I Q + ++QKL + D S GD ++
Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVA 1139
Query: 286 EVERNRSLTQSRTDAEVH 303
V+ ++ T + H
Sbjct: 1140 LVKETVVISPPCTGSSEH 1157
Score = 44.7 bits (104), Expect = 2e-04
Identities = 67/307 (21%), Positives = 130/307 (42%), Gaps = 37/307 (12%)
Query: 14 KRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKL 73
K +L E ++ I+ L TQLE Q + + +LQ E+ + +
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKE---HDERIKQLQVELCEMKQKP------ 1468
Query: 74 IHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNL------LQSQG 127
E+ EE + Q +++LQ + + + +SLQ++ S T+ L ++SQ
Sbjct: 1469 -EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV 1527
Query: 128 SPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSS-------TDEGKE 180
S + K+++TV + + L +EER D ++ ++ S S E KE
Sbjct: 1528 SAQNKEKDTV---LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
Query: 181 KTKLLLERLKALE-AENSALALENENQREQYERCL---DEVANQVVQALLTQKDLREECV 236
K +E LK+ + AE++ +++ +++YE L + V+N+ + + +R+E
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQ 1644
Query: 237 KLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQS 296
+L ++ E + Q+ + ++ K R S + E+E
Sbjct: 1645 ELYGKLRSTEANKKETEKQLQEAEQEMEEM---KEKMRKFAKSKQQKILELEEE----ND 1697
Query: 297 RTDAEVH 303
R AEVH
Sbjct: 1698 RLRAEVH 1704
Score = 43.1 bits (100), Expect = 7e-04
Identities = 88/395 (22%), Positives = 164/395 (41%), Gaps = 77/395 (19%)
Query: 18 LDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHEL 77
+D SL+E + E L LE +EKL V ++ + + +E ++ EL
Sbjct: 1555 MDRSLLENQSLSSSCESLKLALEGLTED--KEKL-VKEIESLKSSKIAESTEWQEKHKEL 1611
Query: 78 EEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETV 137
++E + LQS + V+ E+ER + + +++Q+ + +R S E K+ET
Sbjct: 1612 QKEYEILLQS---YENVSNEAERIQHVVEAVRQEKQELYGKLR-------STEANKKET- 1660
Query: 138 NIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENS 197
+++L E E++ +E E + K K + +LE LE EN
Sbjct: 1661 -----EKQLQEAEQEMEEMKEKMRKFA--------------KSKQQKILE----LEEEND 1697
Query: 198 ALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQ 257
L E + + C++ + L + ++EE ++K + TLS FQ
Sbjct: 1698 RLRAEVHPAGDTAKECMETL-------LSSNASMKEELERVK-------MEYETLSKKFQ 1743
Query: 258 QRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLN-TKSALKCP 316
+ D L +++ DL ++E N S + E H++Q N T+ +
Sbjct: 1744 S-LMSEKDSLSEEVQ---------DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS- 1792
Query: 317 GLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGS-----SYTWHDG-KNLRKRVKEANE 370
IPG ++S S S+ + S + S + ++ HD N +++ + E
Sbjct: 1793 -----IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKE 1847
Query: 371 NLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGT 405
+ E++ + F S +E+ + TL S I T
Sbjct: 1848 RIAGLEEEKQKNKEF-SQTLEN--EKNTLLSQIST 1879
Score = 41.2 bits (95), Expect = 0.003
Identities = 52/253 (20%), Positives = 112/253 (44%), Gaps = 20/253 (7%)
Query: 70 HEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSP 129
H+K I ELE L S++ + + LE E + ++ Q + ET++ + +
Sbjct: 2406 HDKEIKELEN-----LLSQEEEENIVLEEENKKAVDKTNQ-----LMETLKTIKKENIQQ 2455
Query: 130 EQKKEETVNIMVYQEKLSEEERKHKEALEDLHM--VVDEDSRSESSSTDEGKEKTKL--L 185
+ + + V M + + + LE+ H+ ++++D + ++ + K K ++ L
Sbjct: 2456 KAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGL 2515
Query: 186 LERLKALEAENSALALENENQREQYERCL---DEVANQVVQALLTQ-KDLREECVKLKTR 241
+ L +EN+ L E RE + + D Q+++ L Q K+L + KL+ +
Sbjct: 2516 RSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK 2575
Query: 242 VFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSS-GDLLSEVERNRSLTQSRTDA 300
+ + E+ N L F D L +++ S + +S ++ ++ +L
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQD-LSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQL 2634
Query: 301 EVHEHQLNTKSAL 313
+V E +++ SAL
Sbjct: 2635 KVKEEEVHRLSAL 2647
Score = 36.6 bits (83), Expect = 0.066
Identities = 81/407 (19%), Positives = 154/407 (37%), Gaps = 76/407 (18%)
Query: 26 MDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTS------EG---------AMH 70
+ S + I+ L QL+++ + + + + Q E A +TS EG A
Sbjct: 414 VQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASL 473
Query: 71 EKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPE 130
+K + ELE E+ L S L+E+ E+E+ Q+ L+ Q G +
Sbjct: 474 QKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ------------NRTGEAD 521
Query: 131 QKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLK 190
++ E + + ++ S E ++ L E++ + + KE + LLLE +K
Sbjct: 522 REVSEISIVDIANKRSSSAEESGQDVL-------------ENTFSQKHKELSVLLLE-MK 567
Query: 191 ALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLR----EECVKLKTRVFDLE 246
+ E + L L+ + +R A + +L QK+++ E +K +VF LE
Sbjct: 568 EAQEEIAFLKLQLQGKR----------AEEADHEVLDQKEMKQMEGEGIAPIKMKVF-LE 616
Query: 247 QQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQ 306
+ ++ P + L + + +S + S SL + + + Q
Sbjct: 617 DTGQDFPLM------PNEESSLPAVEK---EQASTEHQSRTSEEISLNDAGVELK-STKQ 666
Query: 307 LNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKNLRKRVK 366
KS P +G L S EL+ Y + NL + ++
Sbjct: 667 DGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIE 726
Query: 367 EANEN----------LQEDEDDAVADSVFQSHIIESNCQMRTLDSGI 403
E +N L E+ D ++ S + E Q++ L+ +
Sbjct: 727 EFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNL 773
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 56.2 bits (134), Expect = 8e-08
Identities = 72/333 (21%), Positives = 138/333 (41%), Gaps = 32/333 (9%)
Query: 4 KRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQR 63
KRQL++R + ++ K I+ L Q E +H++ ++ + +
Sbjct: 669 KRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEA 728
Query: 64 TSEGA--MHEKLIHEL---EEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEET 118
SE M +KL+ E ++ +L L++EKR + + ++++ ++ L +Q + E
Sbjct: 729 KSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNED 788
Query: 119 VRNLLQSQGSPEQKK----------EETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDS 168
VRNL QK+ + VN + EK ++E H L ++ M +++ +
Sbjct: 789 VRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNH---LMEMKMNLEKQN 845
Query: 169 RSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERC-----LDEVANQVVQ 223
+ + K L ++ LEAE L RE E C L + Q Q
Sbjct: 846 AELRKERQDADGQMKELQDQ---LEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQ 902
Query: 224 ALLTQKDLREECVKLKTRVFDLEQQNRTL-----SILFQQRVRPTSDLL-LQKLHSRLLD 277
L ++D +++ D EQ R++ S L ++++ ++ + H + L
Sbjct: 903 ELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELT 962
Query: 278 LSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTK 310
+ S E NR+LT + + +LN K
Sbjct: 963 EKDATIASLEETNRTLTSDVANLANEKEELNNK 995
Score = 55.8 bits (133), Expect = 1e-07
Identities = 91/390 (23%), Positives = 155/390 (39%), Gaps = 65/390 (16%)
Query: 28 SNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELE------EER 81
S + + L QL+E + L E ARL++ A+ + + E +L+ E
Sbjct: 553 STEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETA 612
Query: 82 HLRLQSEKRLQEVTLESERNRIQ-----MRSLQQQFSRMEETVRN-------------LL 123
L+L+ E + LESER + LQ + +EE ++N L
Sbjct: 613 KLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQL 672
Query: 124 QSQGSPEQKKEE------TVNIMVYQEKLSEEERKHKEA---LEDLHMVVDEDSRSESSS 174
Q + + +K++ T + V Q+ L +EE +HK L D + + + ++S +
Sbjct: 673 QERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEA 732
Query: 175 TDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREE 234
E ++ KLL ER + EN L LE E + + C + + Q + LL QKD+ E
Sbjct: 733 MKEMEK--KLLEERTLKQKVEN--LLLEAEKRCSLLD-CDLKQSQQKINELLKQKDVLNE 787
Query: 235 CVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLT 294
V+ T + E Q R L+ +DL +Q L +S L E N L
Sbjct: 788 DVRNLTLKIEQETQKRCLT---------QNDLKMQTQQVNTLKMSEKQLKQE---NNHLM 835
Query: 295 QSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSS---SSELSLSSTCSEYSSGS 351
+ + + E +L K G + L +S+ + L C E +
Sbjct: 836 EMKMNLEKQNAELR-KERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKT--- 891
Query: 352 SYTWHDGKNLRKRVKEANENLQEDEDDAVA 381
L K +++ + LQ++ D A
Sbjct: 892 --------KLGKELQQKKQELQDERDSLAA 913
Score = 45.8 bits (107), Expect = 1e-04
Identities = 58/261 (22%), Positives = 108/261 (41%), Gaps = 36/261 (13%)
Query: 61 AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQ----------EVTLESERNRIQMRSLQQ 110
+++ E +K ++ LEE +Q+++ L+ E T + I +R +
Sbjct: 436 SRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVE 495
Query: 111 QFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVD--EDS 168
R E + LLQ + + YQ K E K + D++ + D ED
Sbjct: 496 SALRQLEREKALLQHKNAE------------YQRKADHEADKKRNLENDVNSLKDQLEDL 543
Query: 169 RSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQ 228
+ + ++ EK L +L E +AL + + + E + Q+ Q
Sbjct: 544 KKRNQNSQISTEKVNQLQRQLD----ETNALLRTESDTAARLRKTQAESSKQIQQLESNN 599
Query: 229 KDLREECVKLKTRVFDLEQQ--NRTLSILFQQRVRPTSDLLLQKLHSRLL----DLSSGD 282
+DL+++ L+T LE++ N ++ ++R R ++ L R+ DL +G
Sbjct: 600 RDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGK 659
Query: 283 -LLSEVE-RNRSLTQSRTDAE 301
LL++VE R L + TD E
Sbjct: 660 ILLAKVELEKRQLQERFTDLE 680
Score = 34.7 bits (78), Expect = 0.25
Identities = 43/194 (22%), Positives = 91/194 (46%), Gaps = 14/194 (7%)
Query: 7 LEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSE 66
LEK K L + + + + + LEE +R+L + +A + E+ + +
Sbjct: 939 LEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKD 998
Query: 67 GAMHEKLIHELEEE---RHLRLQSEKR-LQEVTLESERNRIQMRSLQQQFSRMEETVR-N 121
+ E+L +EE ++ Q EK+ L E TL+++ + L + +R E R N
Sbjct: 999 --VQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQ----AVNKLAEIMNRKEPVKRGN 1052
Query: 122 LLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDS--RSESSSTDEGK 179
+ ++ ++ + + +EKL+++ K+++ L ++ + E+S R E T + K
Sbjct: 1053 DTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSK 1112
Query: 180 EK-TKLLLERLKAL 192
+ + L +L+AL
Sbjct: 1113 DSDIEQLRSQLQAL 1126
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 56.2 bits (134), Expect = 8e-08
Identities = 72/303 (23%), Positives = 133/303 (43%), Gaps = 62/303 (20%)
Query: 33 EHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEE-----RHLRLQS 87
+ L Q EE L REK A+ + +RE A R + A E+L +LEE R LR +
Sbjct: 743 QRCLRQAEELREQLEREKEALGQQERERA-RQRQRAELEELRQQLEESSSALTRALRAEF 801
Query: 88 EKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLS 147
EK +E + R+++++ +L+QQ L + + ++E ++ +++L
Sbjct: 802 EKGREE---QERRHQMELNTLKQQL--------ELERQAWEAGRTRKEEAWLLNREQELR 850
Query: 148 EEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQR 207
EE RK ++ +++ +V+ R E+ +E K R+K L R
Sbjct: 851 EEIRKGRD--KEIELVI---HRLEADMALAKEESEKAAESRIKRL--------------R 891
Query: 208 EQYERCLDEVANQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSD-- 265
++YE L E+ +++ L+E C +LK ++ + E +N L L +Q+ R D
Sbjct: 892 DKYEAELSELEQ-------SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 944
Query: 266 ---------------LLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTK 310
++ Q+ RL +S + + + + Q+R E+ E K
Sbjct: 945 AVNEQLSSERSNLAQVIRQEFEDRL--AASEEETRQAKAELATLQARQQLELEEVHRRVK 1002
Query: 311 SAL 313
+AL
Sbjct: 1003 TAL 1005
Score = 31.2 bits (69), Expect = 2.8
Identities = 34/192 (17%), Positives = 81/192 (42%), Gaps = 15/192 (7%)
Query: 49 EKLAVARLQREVAQRTSEGAMHEKLIHELEEER------------HLRLQSEKRLQEVTL 96
EK +LQR+ + H I +L E++ L+ + ++ + V
Sbjct: 606 EKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQ 665
Query: 97 ESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEA 156
++ ++++ L++ S E+ R S+ + + K+ + +KL ++
Sbjct: 666 AQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRR 725
Query: 157 LEDLH--MVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENEN-QREQYERC 213
L+ LH ++ D R+ + +E + L +AL + A + + + E+ +
Sbjct: 726 LKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQ 785
Query: 214 LDEVANQVVQAL 225
L+E ++ + +AL
Sbjct: 786 LEESSSALTRAL 797
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 55.8 bits (133), Expect = 1e-07
Identities = 67/293 (22%), Positives = 125/293 (42%), Gaps = 33/293 (11%)
Query: 32 IEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRL 91
+E L QL+ + + + +V + QRE A+ + + + + +E+H E +
Sbjct: 617 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH-----EAQA 671
Query: 92 QEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEER 151
Q LE +Q+RS QQ+ + E + Q Q + KE ++ V + L EE+R
Sbjct: 672 QVAELE-----LQLRSEQQKATEKERVAQEKDQLQEQLQALKE---SLKVTKGSLEEEKR 723
Query: 152 KHKEALEDLHMVVDEDSRSESSSTDEGKEKTKLLLER---LKALEAENSALALENENQRE 208
+ +ALE+ + E S ++ K + K L E K LEA L ++ + E
Sbjct: 724 RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
Query: 209 QYERCLDEVANQVVQALLTQKDLREECVKL-------KTRVFDLEQQNRTLSILFQQRVR 261
R ++ +A+ Q EC +L + R D +Q+ +FQ+++
Sbjct: 784 VLRR-------ELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLM 836
Query: 262 PTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALK 314
+ +K L + + + ++ +E + L SR E+ E N AL+
Sbjct: 837 TLKE-ECEKARQELQE--AKEKVAGIESHSELQISRQQNELAELHANLARALQ 886
Score = 47.4 bits (111), Expect = 4e-05
Identities = 82/332 (24%), Positives = 142/332 (42%), Gaps = 40/332 (12%)
Query: 1 MEGKRQLEKRDFGKRLS--LDSSLVEYMD---SNKYIEHLLTQLEEQHRSL---WREKLA 52
+E K E RD + L+ L +L + D ++ + QL E++ L RE +
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332
Query: 53 -VARLQREVAQRTSEGAMHEKLIHE-LEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQ 110
+ +LQ + + T E H K E LE++ L + LQ+ E+N I LQ
Sbjct: 333 HLQQLQDALNELTEE---HSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEI----LQG 385
Query: 111 QFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRS 170
+ S++EE +L Q Q +P Q+K E + ++ E L +E L +R
Sbjct: 386 KLSQLEE---HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQL------QARV 436
Query: 171 ESSSTDEGKEKTKLLLER--LKALEAENSALALENENQREQYERCLDEV--ANQVVQALL 226
E T+ G+++ KLL ER + + + S+L + ++ + +E+ A+Q A L
Sbjct: 437 EMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARL 496
Query: 227 TQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDL---------LLQKLHSRLLD 277
T + + +L T ++QQ++ L+ L QQ + L Q L ++
Sbjct: 497 TAQ-VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ 555
Query: 278 LSSGDLLSEVERNRSLTQSRTDAEVHEHQLNT 309
LSS E + + + H QL T
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLAT 587
Score = 47.0 bits (110), Expect = 5e-05
Identities = 70/308 (22%), Positives = 132/308 (42%), Gaps = 64/308 (20%)
Query: 4 KRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQR 63
++Q E+ D +R SL++ + + +E L QLEE+ + L + A+A QRE+A
Sbjct: 1137 QKQQEQADSLER-SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195
Query: 64 TSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLL 123
++ H K E+E ++ ++ E+ER + SL+++ S + R +L
Sbjct: 1196 RTKVQDHSKA----EDEWKAQVARGRQ------EAERKNSLISSLEEEVSILN---RQVL 1242
Query: 124 QSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKEKTK 183
+ +G ++ K +V+ E EK++
Sbjct: 1243 EKEGESKELKR---------------------------LVMAES------------EKSQ 1263
Query: 184 LLLERLKALEAE---NSALALENENQ-REQYERCLDEVANQVVQALLTQKDLREECVKLK 239
L ERL+ L+AE NSA A E + RE+ + +E Q V ++LR+E
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRV----ASENLRQELTSQA 1319
Query: 240 TRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLD---LSSGDLLSEVERNRSLTQS 296
R +L Q+ + F Q+ + S L L+ ++ L L + L +++ ++ +
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 297 RTDAEVHE 304
R E+ +
Sbjct: 1380 RHREELEQ 1387
Score = 45.1 bits (105), Expect = 2e-04
Identities = 74/325 (22%), Positives = 140/325 (43%), Gaps = 32/325 (9%)
Query: 2 EGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVA 61
E K E+ F + SSL+ + S+ I +L EE ++ + ARL +VA
Sbjct: 447 EAKLLAERGHFEEEKQQLSSLITDLQSS--ISNLSQAKEELEQA---SQAHGARLTAQVA 501
Query: 62 QRTSEGAMHEKLIHELEEE-RHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR 120
TSE I + ++E L+ Q++++ ++ ++ + L+ Q ++ +++
Sbjct: 502 SLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK 561
Query: 121 NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE 180
Q +K+E T Q + EER+ D + E E ++
Sbjct: 562 QKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA------ 615
Query: 181 KTKLLLERLK-ALEAENSALALENENQREQYE--RCLDEVANQVVQALLTQKDLREECVK 237
K ++L ++L+ A EA +SA + QRE+ E R ++E+ V A Q + + + +
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675
Query: 238 LKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLS------------SGDLLS 285
L+ ++ EQQ T ++RV D L ++L + L + D L
Sbjct: 676 LELQLRS-EQQKAT----EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730
Query: 286 EVERNRSLTQSRTDAEVHEHQLNTK 310
E +R S ++ T + V +H+ K
Sbjct: 731 EQQRCISELKAETRSLVEQHKRERK 755
Score = 44.3 bits (103), Expect = 3e-04
Identities = 76/356 (21%), Positives = 145/356 (40%), Gaps = 33/356 (9%)
Query: 22 LVEYMDSNKYIEHLLTQLEEQHRS---LWREKLAVARLQREVAQRTSE------GAMHEK 72
L E K +E L QL E H++ + R +LA A + A+ E A E+
Sbjct: 757 LEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816
Query: 73 LIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNLLQSQGSPEQK 132
+EE +++L + E E+ R +++ +++ + +E + LQ +
Sbjct: 817 YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIES--HSELQISRQQNEL 874
Query: 133 KEETVNIMVYQEKLSEEERKHKEALEDLHMVVD-------EDSRSESSSTDEGKEKTKLL 185
E N+ +++ E+E + ++ +DL + + E +R E+ G+++
Sbjct: 875 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
Query: 186 LERLK--ALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKTRVF 243
E +K A + LE E Q Q+ C + A Q ++ Q + E +L+ +
Sbjct: 935 RELVKEPARAGDRQPEWLE-EQQGRQF--CSTQAALQAMEREAEQ--MGNELERLRAALM 989
Query: 244 DLE--------QQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQ 295
+ + QQ R ++ L Q+R R +DL L+K L++ + L+E + Q
Sbjct: 990 ESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQ 1049
Query: 296 SRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGS 351
+ E + + K GL A L + L+ E++SGS
Sbjct: 1050 EALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105
Score = 31.2 bits (69), Expect = 2.8
Identities = 50/273 (18%), Positives = 106/273 (38%), Gaps = 26/273 (9%)
Query: 27 DSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQ 86
+S + + L QL E L +++ A + ++ + + ++ EL+E+ Q
Sbjct: 1581 ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
Query: 87 SEKRLQEVTLESERNRIQMRSLQQQFSRMEETVRNL------LQSQ-GSPEQKKEETVNI 139
+K +E+ E+ER +++ + E+T R+L L++Q +Q+ +
Sbjct: 1641 LQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKF 1700
Query: 140 MVYQEKLSEEERKHKE----ALEDLHMVVDEDS---------RSESSSTDEGKEKTKLLL 186
V + L E + K +++ L + +E + R++ T E +
Sbjct: 1701 QVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPIS 1760
Query: 187 ERLKALEAENSALALENENQREQ--YERCLDEVANQVVQALLTQKDLREECVKL----KT 240
+RL +L R Q E LD + + + + + R ++ T
Sbjct: 1761 QRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMT 1820
Query: 241 RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHS 273
+ D+E+ + S + R P S L+ S
Sbjct: 1821 KKLDVEEPDSANSSFYSTRSAPASQASLRATSS 1853
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,074,682
Number of Sequences: 37866
Number of extensions: 1061146
Number of successful extensions: 9546
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 145
Number of HSP's successfully gapped in prelim test: 988
Number of HSP's that attempted gapping in prelim test: 5860
Number of HSP's gapped (non-prelim): 3034
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.