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Search of human proteins with 42516565
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo
sapiens]
(911 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 1882 0.0
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 1882 0.0
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 1634 0.0
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 1115 0.0
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 1115 0.0
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 1115 0.0
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 137 6e-32
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 135 2e-31
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 135 2e-31
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 135 2e-31
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 133 7e-31
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 133 7e-31
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens] 132 2e-30
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 121 3e-27
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 119 1e-26
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 118 3e-26
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 118 3e-26
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 118 3e-26
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 114 4e-25
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 114 4e-25
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 111 3e-24
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 110 6e-24
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 109 1e-23
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 107 7e-23
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] 102 1e-21
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens] 100 1e-20
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 95 3e-19
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 90 8e-18
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 90 8e-18
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 90 8e-18
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 1882 bits (4874), Expect = 0.0
Identities = 911/911 (100%), Positives = 911/911 (100%)
Query: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH
Sbjct: 32 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91
Query: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK
Sbjct: 92 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151
Query: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ
Sbjct: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211
Query: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD
Sbjct: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
Query: 241 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 300
AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE
Sbjct: 272 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 331
Query: 301 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 360
NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET
Sbjct: 332 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 391
Query: 361 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 420
VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA
Sbjct: 392 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 451
Query: 421 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 480
PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG
Sbjct: 452 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 511
Query: 481 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD 540
KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD
Sbjct: 512 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD 571
Query: 541 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 600
CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST
Sbjct: 572 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 631
Query: 601 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 660
HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD
Sbjct: 632 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 691
Query: 661 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 720
QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK
Sbjct: 692 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 751
Query: 721 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 780
TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH
Sbjct: 752 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 811
Query: 781 TCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPG 840
TCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPG
Sbjct: 812 TCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPG 871
Query: 841 PIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQA 900
PIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQA
Sbjct: 872 PIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQA 931
Query: 901 EEKIEVETRSL 911
EEKIEVETRSL
Sbjct: 932 EEKIEVETRSL 942
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 1882 bits (4874), Expect = 0.0
Identities = 911/911 (100%), Positives = 911/911 (100%)
Query: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH
Sbjct: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
Query: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK
Sbjct: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
Query: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ
Sbjct: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
Query: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD
Sbjct: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
Query: 241 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 300
AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE
Sbjct: 241 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 300
Query: 301 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 360
NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET
Sbjct: 301 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 360
Query: 361 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 420
VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA
Sbjct: 361 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 420
Query: 421 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 480
PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG
Sbjct: 421 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 480
Query: 481 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD 540
KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD
Sbjct: 481 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD 540
Query: 541 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 600
CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST
Sbjct: 541 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 600
Query: 601 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 660
HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD
Sbjct: 601 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 660
Query: 661 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 720
QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK
Sbjct: 661 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 720
Query: 721 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 780
TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH
Sbjct: 721 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 780
Query: 781 TCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPG 840
TCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPG
Sbjct: 781 TCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPG 840
Query: 841 PIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQA 900
PIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQA
Sbjct: 841 PIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQA 900
Query: 901 EEKIEVETRSL 911
EEKIEVETRSL
Sbjct: 901 EEKIEVETRSL 911
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 1634 bits (4230), Expect = 0.0
Identities = 794/805 (98%), Positives = 796/805 (98%), Gaps = 8/805 (0%)
Query: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH
Sbjct: 32 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91
Query: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK
Sbjct: 92 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151
Query: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ
Sbjct: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211
Query: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD
Sbjct: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
Query: 241 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 300
AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE
Sbjct: 272 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 331
Query: 301 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 360
NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET
Sbjct: 332 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 391
Query: 361 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 420
VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA
Sbjct: 392 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 451
Query: 421 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 480
PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG
Sbjct: 452 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 511
Query: 481 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD 540
KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK SWFWGPVVTLQD
Sbjct: 512 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK--------SWFWGPVVTLQD 563
Query: 541 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 600
CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST
Sbjct: 564 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 623
Query: 601 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 660
HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD
Sbjct: 624 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 683
Query: 661 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 720
QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK
Sbjct: 684 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 743
Query: 721 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 780
TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH
Sbjct: 744 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 803
Query: 781 TCQIEAEKIEKRRKTELEIFIRLNR 805
TCQIEAEKIEKRRKTELEIFIR+ +
Sbjct: 804 TCQIEAEKIEKRRKTELEIFIRVKK 828
Score = 35.0 bits (79), Expect = 0.32
Identities = 31/103 (30%), Positives = 42/103 (40%), Gaps = 19/103 (18%)
Query: 785 EAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDN 844
EA+K +R L I E S FY IS QW ++++F + PGPI N
Sbjct: 710 EAQKERRRISNLLNIM---------EPSLLQFY-ISRQWLNKFKTFAE------PGPISN 753
Query: 845 TKIAVTKCGNVMLRQGADSG---QISEETWNFLQSIYGGGPEV 884
G + G + + W+ L S YGGGP V
Sbjct: 754 NDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV 796
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 1115 bits (2884), Expect = 0.0
Identities = 553/927 (59%), Positives = 689/927 (74%), Gaps = 29/927 (3%)
Query: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
M R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+ C YVGCGES DH
Sbjct: 1 MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
Query: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
STIH+Q KH LTVNLTT R+WCYAC KEVFL+++L P + + E QD
Sbjct: 61 STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
Query: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
PS+ LK +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP VVPT+L GIK VNP FRGY+QQD
Sbjct: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
Query: 241 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 295
QEFLRCLMD LHEELKE V+ D + T+E E D+S S+ +F SC+S +
Sbjct: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
Query: 296 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 355
SDR E + R ET +LI D+ + K+ K++ + + + + D+D D
Sbjct: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
Query: 356 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 409
+ L++Q R+S E D H S P + + +LS+SP
Sbjct: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
Query: 410 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 466
P++ + +AP + KKAQ S R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS
Sbjct: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
Query: 467 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSC 526
T+ETFQDLSLPIPGKEDLAKLHS+ + K G+CG++YA QGW+AF +EY++RFVVSC
Sbjct: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
Query: 527 VPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 586
PSWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV PEILCIHLK
Sbjct: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
Query: 587 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 646
RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+ +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
Query: 647 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 706
C+N +N WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L + EPSL
Sbjct: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
Query: 707 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 766
L+FY+SR+WLNKF TFAEPGPI+N FLC HGG+PP K YI+DLV++LPQN+W++LY+R
Sbjct: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
Query: 767 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFRE 826
+GGGPAVNHLY+C CQ+E E + KRR+ E++ FI+LN+AFQ E+SP YCISMQWFRE
Sbjct: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFRE 827
Query: 827 WESFVKGKDGDPPGPIDNTKIAVTK-CGNVMLRQGADSGQISEETWNFLQSIYGGGPEVI 885
WE+FVKGKD +PPGPIDN++IA K G+V L+QGAD GQISEETW +L S+YGGGPE+
Sbjct: 828 WEAFVKGKDNEPPGPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIA 887
Query: 886 LRPPVVH-VDPDILQAEEKIEVETRSL 911
+R V + P+ L E+KIE ETR++
Sbjct: 888 IRQSVAQPLGPENLHGEQKIEAETRAV 914
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 1115 bits (2884), Expect = 0.0
Identities = 553/927 (59%), Positives = 689/927 (74%), Gaps = 29/927 (3%)
Query: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
M R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+ C YVGCGES DH
Sbjct: 1 MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
Query: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
STIH+Q KH LTVNLTT R+WCYAC KEVFL+++L P + + E QD
Sbjct: 61 STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
Query: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
PS+ LK +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP VVPT+L GIK VNP FRGY+QQD
Sbjct: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
Query: 241 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 295
QEFLRCLMD LHEELKE V+ D + T+E E D+S S+ +F SC+S +
Sbjct: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
Query: 296 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 355
SDR E + R ET +LI D+ + K+ K++ + + + + D+D D
Sbjct: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
Query: 356 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 409
+ L++Q R+S E D H S P + + +LS+SP
Sbjct: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
Query: 410 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 466
P++ + +AP + KKAQ S R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS
Sbjct: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
Query: 467 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSC 526
T+ETFQDLSLPIPGKEDLAKLHS+ + K G+CG++YA QGW+AF +EY++RFVVSC
Sbjct: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
Query: 527 VPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 586
PSWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV PEILCIHLK
Sbjct: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
Query: 587 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 646
RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+ +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
Query: 647 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 706
C+N +N WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L + EPSL
Sbjct: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
Query: 707 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 766
L+FY+SR+WLNKF TFAEPGPI+N FLC HGG+PP K YI+DLV++LPQN+W++LY+R
Sbjct: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
Query: 767 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFRE 826
+GGGPAVNHLY+C CQ+E E + KRR+ E++ FI+LN+AFQ E+SP YCISMQWFRE
Sbjct: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFRE 827
Query: 827 WESFVKGKDGDPPGPIDNTKIAVTK-CGNVMLRQGADSGQISEETWNFLQSIYGGGPEVI 885
WE+FVKGKD +PPGPIDN++IA K G+V L+QGAD GQISEETW +L S+YGGGPE+
Sbjct: 828 WEAFVKGKDNEPPGPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIA 887
Query: 886 LRPPVVH-VDPDILQAEEKIEVETRSL 911
+R V + P+ L E+KIE ETR++
Sbjct: 888 IRQSVAQPLGPENLHGEQKIEAETRAV 914
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 1115 bits (2884), Expect = 0.0
Identities = 553/927 (59%), Positives = 689/927 (74%), Gaps = 29/927 (3%)
Query: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
M R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+ C YVGCGES DH
Sbjct: 1 MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
Query: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
STIH+Q KH LTVNLTT R+WCYAC KEVFL+++L P + + E QD
Sbjct: 61 STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
Query: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
PS+ LK +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP VVPT+L GIK VNP FRGY+QQD
Sbjct: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
Query: 241 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 295
QEFLRCLMD LHEELKE V+ D + T+E E D+S S+ +F SC+S +
Sbjct: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
Query: 296 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 355
SDR E + R ET +LI D+ + K+ K++ + + + + D+D D
Sbjct: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
Query: 356 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 409
+ L++Q R+S E D H S P + + +LS+SP
Sbjct: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
Query: 410 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 466
P++ + +AP + KKAQ S R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS
Sbjct: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
Query: 467 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSC 526
T+ETFQDLSLPIPGKEDLAKLHS+ + K G+CG++YA QGW+AF +EY++RFVVSC
Sbjct: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
Query: 527 VPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 586
PSWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV PEILCIHLK
Sbjct: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
Query: 587 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 646
RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+ +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
Query: 647 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 706
C+N +N WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L + EPSL
Sbjct: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
Query: 707 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 766
L+FY+SR+WLNKF TFAEPGPI+N FLC HGG+PP K YI+DLV++LPQN+W++LY+R
Sbjct: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
Query: 767 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFRE 826
+GGGPAVNHLY+C CQ+E E + KRR+ E++ FI+LN+AFQ E+SP YCISMQWFRE
Sbjct: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFRE 827
Query: 827 WESFVKGKDGDPPGPIDNTKIAVTK-CGNVMLRQGADSGQISEETWNFLQSIYGGGPEVI 885
WE+FVKGKD +PPGPIDN++IA K G+V L+QGAD GQISEETW +L S+YGGGPE+
Sbjct: 828 WEAFVKGKDNEPPGPIDNSRIAQVKGSGHVQLKQGADYGQISEETWTYLNSLYGGGPEIA 887
Query: 886 LRPPVVH-VDPDILQAEEKIEVETRSL 911
+R V + P+ L E+KIE ETR++
Sbjct: 888 IRQSVAQPLGPENLHGEQKIEAETRAV 914
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 137 bits (344), Expect = 6e-32
Identities = 81/254 (31%), Positives = 122/254 (48%), Gaps = 45/254 (17%)
Query: 442 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGS 501
+V++ IF G + + V CL C S + F DLSL IP + + + +
Sbjct: 308 TVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQEN--------- 358
Query: 502 CGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEK 561
GPV +L+DCL +F +EL +Y C K
Sbjct: 359 -------------------------------GPVCSLRDCLRSFTDLEELDETELYMCHK 387
Query: 562 CKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFL--AKDS 619
CKK + K +Q P++LC+HLKRF K+ T+V FPL GLD++ +L ++S
Sbjct: 388 CKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENS 447
Query: 620 PAQIVTYDLLSVICHHGT-ASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYV 678
+ YDL +V+ HHG+ SGHY AY + W+ F+D +VT E TV A+AY+
Sbjct: 448 GPESCLYDLAAVVVHHGSGVGSGHYTAYATH--EGRWFHFNDSTVTLTDEETVVKAKAYI 505
Query: 679 LFYRKSSEEAQKER 692
LFY + +A ++
Sbjct: 506 LFYVEHQAKAGSDK 519
Score = 101 bits (251), Expect = 4e-21
Identities = 84/292 (28%), Positives = 126/292 (43%), Gaps = 59/292 (20%)
Query: 8 CPHLDSVGEITKEDLI----QKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTI 63
CPHL S I + S C C+ + W CL CS V CG H+
Sbjct: 3 CPHLSSSVCIAPDSAKFPNGSPSSWCCSVCR-SNKSPWVCLT--CSSVHCGRYVNGHAKK 59
Query: 64 HSQETK----------------HYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQ 107
H ++ + H + ++ ++ +CY C V D KLG + VR+
Sbjct: 60 HYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGL---VQKVRE 116
Query: 108 PHQIQENSV------QDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGN 161
Q ENS + K+ N+TL + L+ V A TGL+N+GN
Sbjct: 117 HLQNLENSAFTADRHKKRKLLENSTLNSKLLKV----------NGSTTAICATGLRNLGN 166
Query: 162 TCYMNAALQALSNCPPLTQFFLDCGGL----------------ARTDKKPAICKSYLKLM 205
TC+MNA LQ+LSN +F + + ++ D ++ + + K +
Sbjct: 167 TCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTL 226
Query: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 257
LW S+ + P +LF + + P FRGY QQDA EF+R L+D LH EL+
Sbjct: 227 CALWQGSQT-AFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQ 277
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 135 bits (339), Expect = 2e-31
Identities = 81/258 (31%), Positives = 121/258 (46%), Gaps = 56/258 (21%)
Query: 424 KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483
K A+ A K K+ ++ S+I +F G S+VQCLTC + S T E F LSLP
Sbjct: 905 KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP------ 955
Query: 484 LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLA 543
+ C TLQDCL
Sbjct: 956 ------------LASTSKC----------------------------------TLQDCLR 969
Query: 544 AFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 603
F ++L +N + C C+ R+ +K ++ P +L +HLKRF ++ + K+ T V
Sbjct: 970 LFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVD 1029
Query: 604 FPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSV 663
FPLE LDL ++ + Y+L SV H+G GHY AYC+N W++FDD V
Sbjct: 1030 FPLENLDLSQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEV 1088
Query: 664 TEVSESTVQNAEAYVLFY 681
+++S S+V+++ AY+LFY
Sbjct: 1089 SDISVSSVKSSAAYILFY 1106
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)
Query: 153 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 206
LTGL+N+GNTCYMN+ LQ L N P L +F D K + + + +M
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 207 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 258
LW + + P I +N F GYSQQD+QE L LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 135 bits (339), Expect = 2e-31
Identities = 81/258 (31%), Positives = 121/258 (46%), Gaps = 56/258 (21%)
Query: 424 KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483
K A+ A K K+ ++ S+I +F G S+VQCLTC + S T E F LSLP
Sbjct: 905 KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP------ 955
Query: 484 LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLA 543
+ C TLQDCL
Sbjct: 956 ------------LASTSKC----------------------------------TLQDCLR 969
Query: 544 AFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 603
F ++L +N + C C+ R+ +K ++ P +L +HLKRF ++ + K+ T V
Sbjct: 970 LFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVD 1029
Query: 604 FPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSV 663
FPLE LDL ++ + Y+L SV H+G GHY AYC+N W++FDD V
Sbjct: 1030 FPLENLDLSQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEV 1088
Query: 664 TEVSESTVQNAEAYVLFY 681
+++S S+V+++ AY+LFY
Sbjct: 1089 SDISVSSVKSSAAYILFY 1106
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)
Query: 153 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 206
LTGL+N+GNTCYMN+ LQ L N P L +F D K + + + +M
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 207 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 258
LW + + P I +N F GYSQQD+QE L LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 135 bits (339), Expect = 2e-31
Identities = 81/258 (31%), Positives = 121/258 (46%), Gaps = 56/258 (21%)
Query: 424 KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483
K A+ A K K+ ++ S+I +F G S+VQCLTC + S T E F LSLP
Sbjct: 905 KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP------ 955
Query: 484 LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLA 543
+ C TLQDCL
Sbjct: 956 ------------LASTSKC----------------------------------TLQDCLR 969
Query: 544 AFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 603
F ++L +N + C C+ R+ +K ++ P +L +HLKRF ++ + K+ T V
Sbjct: 970 LFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVD 1029
Query: 604 FPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSV 663
FPLE LDL ++ + Y+L SV H+G GHY AYC+N W++FDD V
Sbjct: 1030 FPLENLDLSQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEV 1088
Query: 664 TEVSESTVQNAEAYVLFY 681
+++S S+V+++ AY+LFY
Sbjct: 1089 SDISVSSVKSSAAYILFY 1106
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)
Query: 153 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 206
LTGL+N+GNTCYMN+ LQ L N P L +F D K + + + +M
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 207 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 258
LW + + P I +N F GYSQQD+QE L LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 133 bits (335), Expect = 7e-31
Identities = 82/252 (32%), Positives = 123/252 (48%), Gaps = 52/252 (20%)
Query: 434 KKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHP 493
+K ++ S I D+F G + SS+ C C S + F DLSLPI
Sbjct: 192 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 236
Query: 494 TSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKG 553
A +G+ P VTL DC+ F D L G
Sbjct: 237 -------------AKRGY----------------------PEVTLMDCMRLFTKEDVLDG 261
Query: 554 DNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQP 613
D +C +C+ + +K +Q FP+IL +HLKRF + ++K++T V+FPL LDL+
Sbjct: 262 DEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLRE 321
Query: 614 FLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQN 673
F ++++ + Y+L +V H GT GHY AYCR+ W+ F+D SVT +S S V+
Sbjct: 322 FASENTNHAV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRT 379
Query: 674 AEAYVLFYRKSS 685
++AY+LFY +S
Sbjct: 380 SDAYLLFYELAS 391
Score = 84.7 bits (208), Expect = 4e-16
Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%)
Query: 150 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC--------GGLARTDKKPAICKSY 201
A+GL GL+N+GNTC+MN+ LQ LSN L + L G A T A+ + +
Sbjct: 54 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT----ALVEEF 109
Query: 202 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVM 261
KL+ +W S V P+ I+ P F GY+QQDAQEFLR L+D LH E+ +
Sbjct: 110 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 169
Query: 262 EVEEDPQTI 270
+ +P+ +
Sbjct: 170 RPKSNPENL 178
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 133 bits (335), Expect = 7e-31
Identities = 82/252 (32%), Positives = 123/252 (48%), Gaps = 52/252 (20%)
Query: 434 KKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHP 493
+K ++ S I D+F G + SS+ C C S + F DLSLPI
Sbjct: 401 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 445
Query: 494 TSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKG 553
A +G+ P VTL DC+ F D L G
Sbjct: 446 -------------AKRGY----------------------PEVTLMDCMRLFTKEDVLDG 470
Query: 554 DNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQP 613
D +C +C+ + +K +Q FP+IL +HLKRF + ++K++T V+FPL LDL+
Sbjct: 471 DEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLRE 530
Query: 614 FLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQN 673
F ++++ + Y+L +V H GT GHY AYCR+ W+ F+D SVT +S S V+
Sbjct: 531 FASENTNHAV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRT 588
Query: 674 AEAYVLFYRKSS 685
++AY+LFY +S
Sbjct: 589 SDAYLLFYELAS 600
Score = 84.7 bits (208), Expect = 4e-16
Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%)
Query: 150 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC--------GGLARTDKKPAICKSY 201
A+GL GL+N+GNTC+MN+ LQ LSN L + L G A T A+ + +
Sbjct: 263 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT----ALVEEF 318
Query: 202 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVM 261
KL+ +W S V P+ I+ P F GY+QQDAQEFLR L+D LH E+ +
Sbjct: 319 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 378
Query: 262 EVEEDPQTI 270
+ +P+ +
Sbjct: 379 RPKSNPENL 387
>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
Length = 814
Score = 132 bits (331), Expect = 2e-30
Identities = 176/805 (21%), Positives = 294/805 (36%), Gaps = 160/805 (19%)
Query: 7 HCPHLDSVGEITKEDLIQKSLGTCQDCK----------VQGPNLWACLENRCSYVGCGE- 55
H H SV + K + + C +C V ++W CL +C + GCG+
Sbjct: 40 HVSHAISVNHV-KRAIAENLWSVCSECLKERRFYDGQLVLTSDIWLCL--KCGFQGCGKN 96
Query: 56 SQVDHSTIHSQETK---HYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQ 112
S+ HS H + ++ H + +NL+T +WCY C D KL T + + Q
Sbjct: 97 SESQHSLKHFKSSRTEPHCIIINLSTWIIWCYEC------DEKLSTHCNKKVLAQ----- 145
Query: 113 ENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARG------LTGLKNIGNTCYMN 166
+ DF + +T + L E E DE++ G + G+ N+GNTC+ N
Sbjct: 146 ---IVDFLQKHASKTQTSAFSRIMKLCEEKCETDEIQKGGKCRNLSVRGITNLGNTCFFN 202
Query: 167 AALQALSNCPPLTQFFLDCGGLARTDK-----------------KPAICKSYLKLMTELW 209
A +Q L+ LT + + K +P S L L
Sbjct: 203 AVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDPLVVELSRPGPLTSALFLFLHSM 262
Query: 210 HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEE----LKEQVMEVEE 265
++ G + P LF + P F+ + QQD+QE L L+D + E ++ +++
Sbjct: 263 KETEKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFN 322
Query: 266 DPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENN 325
+P T T ++ + + E + C N T D +
Sbjct: 323 NPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEECANISTVKDPFIDISL 382
Query: 326 SEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVH 385
+ + K + ++NK S E D DR S + T++ N + + HS + + +H
Sbjct: 383 PIIEERVSKPLLWGRMNKYRSLRETDHDRYSGNVTIE-NIHQPRAAKKHSSSKDKSQLIH 441
Query: 386 S----NDLSTPQILPSNEGVN-----------------PRLSASPPKSGNLWPGLAPPHK 424
LS+ + + + N RL+ SP + +
Sbjct: 442 DRKCIRKLSSGETVTYQKNENLEMNGDSLMFASLMNSESRLNESPTDDSEKEASHSESNV 501
Query: 425 KAQ---SASPKRKKQHKKYRS----------VISDIFDGTIISSVQCLTCDRVSVTLETF 471
A S S KQ +RS + + G ++ + + + D+ +
Sbjct: 502 DADSEPSESESASKQTGLFRSSSGSGVQPDGPLYPLSAGKLLYTKETDSGDKEMAEAISE 561
Query: 472 QDLSLPIPGKEDLAKLHSSSHPTSIVK-----AGSCGEAYAPQGWIAFFMEYVKRFVVSC 526
LS + G +D + + P +I G +Y+PQ F + ++ +
Sbjct: 562 LRLSSTVTGDQDFDR---ENQPLNISNNLCFLEGKHLRSYSPQN---AFQTLSQSYITT- 614
Query: 527 VPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLR-------------------N 567
++Q CL F + + L G+N CE C K + N
Sbjct: 615 ------SKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKYQEETSFAEKKVEGVYTN 668
Query: 568 GVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLA----KDSPAQI 623
K + P +L +HLKRF + K++ HV FPL LDL PF + S
Sbjct: 669 ARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLM-LDLAPFCSATCKNASVGDK 727
Query: 624 VTYDLLSVICHHGTASSGHYIAYCR-------------------------NNLNNLWYEF 658
V Y L ++ H G+ GHY AY + N W
Sbjct: 728 VLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKLSEHNTKKKNVPGLKAADNESAGQWVHV 787
Query: 659 DDQSVTEVSESTVQNAEAYVLFYRK 683
D + V ES +A+AY+LFY +
Sbjct: 788 SDTYLQVVPESRALSAQAYLLFYER 812
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 121 bits (304), Expect = 3e-27
Identities = 80/255 (31%), Positives = 112/255 (43%), Gaps = 45/255 (17%)
Query: 443 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 502
+I IF G + S V C C VS T++ F D+SL +PG SS P + GS
Sbjct: 296 IIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPG---------SSTPFWPLSPGSE 346
Query: 503 GEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKC 562
G + ++ TL DCL F + L C C
Sbjct: 347 GNVVNGESHVS--------------------GTTTLTDCLRRFTRPEHLGSSAKIKCSGC 386
Query: 563 KKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAK----- 617
+ K ++ P + C HLKRF H KI+T+VSFPLE LD+ PF+A
Sbjct: 387 HSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLE-LDMTPFMASSKESR 445
Query: 618 ---------DSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSE 668
DS Y L +V+ H GT SGHY ++ R + + W++ DD +T+ S
Sbjct: 446 MNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQH-KDQWFKCDDAIITKASI 504
Query: 669 STVQNAEAYVLFYRK 683
V ++E Y+LFY K
Sbjct: 505 KDVLDSEGYLLFYHK 519
Score = 69.7 bits (169), Expect = 1e-11
Identities = 57/235 (24%), Positives = 96/235 (40%), Gaps = 25/235 (10%)
Query: 30 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE 89
C C V L +CL C + GC + H H++ +H L ++L ++C+ C
Sbjct: 63 CHVCGVHLNRLHSCLY--CVFFGCFTKKHIHE--HAKAKRHNLAIDLMYGGIYCFLCQDY 118
Query: 90 VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR 149
++ + + + Q + +Q +T T ++E + + R
Sbjct: 119 IY-------DKDMEIIAKEEQRKAWKMQGVGEKFSTWEPTKR-------ELELLKHNPKR 164
Query: 150 AR-------GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYL 202
+ GL GL N+GNTC+MN +QAL++ P L FFL + +
Sbjct: 165 RKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEM 224
Query: 203 KLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 257
+ + ++ +P L + T GY QQDA EFL +D+LH K
Sbjct: 225 SSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCK 279
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 119 bits (299), Expect = 1e-26
Identities = 81/270 (30%), Positives = 121/270 (44%), Gaps = 48/270 (17%)
Query: 443 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 502
+I IF G + S V C C VS T++ D+SL +PG +S P S + S
Sbjct: 198 IIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS------CTSFWPMSPGRESSV 251
Query: 503 -GEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEK 561
GE++ P + TL DCL F + L C
Sbjct: 252 NGESHIPG-------------------------ITTLTDCLRRFTRPEHLGSSAKIKCGS 286
Query: 562 CKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA 621
C+ + K + P + C H KRF H KI+T++SFPLE LD+ PF+A +
Sbjct: 287 CQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLE-LDMTPFMASSKES 345
Query: 622 ------QIVT--------YDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVS 667
Q+ T Y L +V+ H GT SGHY ++ R++ + W++ DD +T+ S
Sbjct: 346 RMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHH-KDQWFKCDDAVITKAS 404
Query: 668 ESTVQNAEAYVLFYRKSSEEAQKERRRISN 697
V ++E Y+LFY K E + E+ + N
Sbjct: 405 IKDVLDSEGYLLFYHKQVLEHESEKVKEMN 434
Score = 64.3 bits (155), Expect = 5e-10
Identities = 50/149 (33%), Positives = 67/149 (44%), Gaps = 6/149 (4%)
Query: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICK--SYLKLMTELW 209
GL GL N+GNTC+MN +QAL++ P L FFL P +C L EL
Sbjct: 76 GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEM-PSPELCLVCEMSSLFREL- 133
Query: 210 HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK-EQVMEVEEDPQ 268
+ P VP L + GY QQDA EFL +D+LH K + V + +P
Sbjct: 134 YSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPN 193
Query: 269 TIT-TEETMEEDKSQSDVDFQSCESCSNS 296
+ + QSDV Q+C S +
Sbjct: 194 HCNCIIDQIFTGGLQSDVTCQACHGVSTT 222
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 118 bits (295), Expect = 3e-26
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)
Query: 536 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 595
V L+DC+ F + L + + C CKK + K + + P+IL +HLKRF + +
Sbjct: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
Query: 596 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 655
K+ T V FP+ GL++ F+ S A+ YDL++V H+G GHY AY +N LN W
Sbjct: 836 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
Query: 656 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 690
Y FDD +V+ SE + AYVLFY++ +E K
Sbjct: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 929
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)
Query: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 205
GL GL N+GNTC+MN+ALQ LSN PLT +FL A ++ K I ++Y +L+
Sbjct: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
Query: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 261
++W R V P + P F GY QQD+QE L L+D LHE+L K+ +
Sbjct: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
Query: 262 EVEE---DPQTITTEETMEEDKSQSD 284
E+++ P + +E E + ++D
Sbjct: 419 ELKDANGRPDAVVAKEAWENHRLRND 444
Score = 39.7 bits (91), Expect = 0.013
Identities = 20/42 (47%), Positives = 27/42 (64%)
Query: 442 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483
SVI D F G S++ C C +VSVT + F L+LP+P K+D
Sbjct: 445 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
Score = 36.2 bits (82), Expect = 0.14
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 14/93 (15%)
Query: 814 ATFYCISMQWFREWESFV---------KGKDGDPPGPIDNTKIAVTKCGNVM---LRQGA 861
A +Y I +WF++W+ +V G+ PGPIDN+ + + L
Sbjct: 32 AQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDEL 91
Query: 862 DSGQISEETWNFLQSIYG--GGPEVILRPPVVH 892
D + E WN L + YG G + I+R V H
Sbjct: 92 DYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEH 124
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 118 bits (295), Expect = 3e-26
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)
Query: 536 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 595
V L+DC+ F + L + + C CKK + K + + P+IL +HLKRF + +
Sbjct: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
Query: 596 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 655
K+ T V FP+ GL++ F+ S A+ YDL++V H+G GHY AY +N LN W
Sbjct: 789 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
Query: 656 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 690
Y FDD +V+ SE + AYVLFY++ +E K
Sbjct: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 882
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)
Query: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 205
GL GL N+GNTC+MN+ALQ LSN PLT +FL A ++ K I ++Y +L+
Sbjct: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
Query: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 261
++W R V P + P F GY QQD+QE L L+D LHE+L K+ +
Sbjct: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
Query: 262 EVEE---DPQTITTEETMEEDKSQSD 284
E+++ P + +E E + ++D
Sbjct: 372 ELKDANGRPDAVVAKEAWENHRLRND 397
Score = 39.7 bits (91), Expect = 0.013
Identities = 20/42 (47%), Positives = 27/42 (64%)
Query: 442 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483
SVI D F G S++ C C +VSVT + F L+LP+P K+D
Sbjct: 398 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
Score = 36.2 bits (82), Expect = 0.14
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 14/93 (15%)
Query: 814 ATFYCISMQWFREWESFV---------KGKDGDPPGPIDNTKIAVTKCGNVM---LRQGA 861
A +Y I +WF++W+ +V G+ PGPIDN+ + + L
Sbjct: 32 AQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDEL 91
Query: 862 DSGQISEETWNFLQSIYG--GGPEVILRPPVVH 892
D + E WN L + YG G + I+R V H
Sbjct: 92 DYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEH 124
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 118 bits (295), Expect = 3e-26
Identities = 67/198 (33%), Positives = 97/198 (48%), Gaps = 23/198 (11%)
Query: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 596
TL C + + L D+ + C CK+L+ G + P++L IHLKRFR E
Sbjct: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
Query: 597 KISTHVSFPLEGLDLQPFLAKDSPA---------------------QIVTYDLLSVICHH 635
K+ V FPL GLD+ P + K S + + YDL +V HH
Sbjct: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
Query: 636 GTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRI 695
GT GHY AYC+N+++ LWY FDD V ++SE V AY+LFY++ + A
Sbjct: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
Query: 696 SNLLNIMEPSLLQFYISR 713
S++ SL + ++SR
Sbjct: 775 SSVAGSTSSSLCEHWVSR 792
Score = 56.6 bits (135), Expect = 1e-07
Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 30/147 (20%)
Query: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LDCGGLARTDKKP--------------A 196
G+ GL+N GNTC+MNA LQ LSN ++ L R + P
Sbjct: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
Query: 197 ICKSYLKLMTELW-------HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 249
+ + L+ LW H ++V Q +RG SQ DAQEFL L+
Sbjct: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQ--------YRGNSQHDAQEFLLWLL 237
Query: 250 DLLHEELKEQVMEVEEDPQTITTEETM 276
D +HE+L V + + P +E M
Sbjct: 238 DRVHEDLNHSVKQSGQPPLKPPSETDM 264
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 114 bits (285), Expect = 4e-25
Identities = 96/349 (27%), Positives = 140/349 (40%), Gaps = 63/349 (18%)
Query: 338 CNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPS 397
C +N F K S S + QE +K+ + E ++ P IL +
Sbjct: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLE----INRRGRRAPPILAN 330
Query: 398 NEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQ 457
+P P + G L P A+ K+ ++ S I D+F G + S ++
Sbjct: 331 GPVPSP-----PRRGGALLE--EPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLK 383
Query: 458 CLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFME 517
C C S T E F DLSLPIP K
Sbjct: 384 CQACGYRSTTFEVFCDLSLPIPKKG----------------------------------- 408
Query: 518 YVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNF 577
F G V+L+DC F +EL+ +N C++C++ K VQ F
Sbjct: 409 -------------FAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRF 455
Query: 578 PEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGT 637
P IL +HL RF K S V FPL+ L L F + + + + Y L ++ H G+
Sbjct: 456 PRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV--YQLYALCNHSGS 513
Query: 638 ASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSE 686
GHY A CR W+ ++D V+ VSE+ V ++E YVLFY+ E
Sbjct: 514 VHYGHYTALCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQLMQE 560
Score = 78.6 bits (192), Expect = 3e-14
Identities = 45/118 (38%), Positives = 65/118 (55%), Gaps = 9/118 (7%)
Query: 148 LRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSY 201
L G GL+N+GNTC++NA LQ LS+ PL F L + G R + + +++
Sbjct: 206 LLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAF 262
Query: 202 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQ 259
++ LWH +V PT + P+F GYSQQDAQEFL+ LM+ LH E+ +
Sbjct: 263 ADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR 320
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 114 bits (285), Expect = 4e-25
Identities = 96/349 (27%), Positives = 140/349 (40%), Gaps = 63/349 (18%)
Query: 338 CNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPS 397
C +N F K S S + QE +K+ + E ++ P IL +
Sbjct: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLE----INRRGRRAPPILAN 330
Query: 398 NEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQ 457
+P P + G L P A+ K+ ++ S I D+F G + S ++
Sbjct: 331 GPVPSP-----PRRGGALLE--EPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLK 383
Query: 458 CLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFME 517
C C S T E F DLSLPIP K
Sbjct: 384 CQACGYRSTTFEVFCDLSLPIPKKG----------------------------------- 408
Query: 518 YVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNF 577
F G V+L+DC F +EL+ +N C++C++ K VQ F
Sbjct: 409 -------------FAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRF 455
Query: 578 PEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGT 637
P IL +HL RF K S V FPL+ L L F + + + + Y L ++ H G+
Sbjct: 456 PRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV--YQLYALCNHSGS 513
Query: 638 ASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSE 686
GHY A CR W+ ++D V+ VSE+ V ++E YVLFY+ E
Sbjct: 514 VHYGHYTALCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQLMQE 560
Score = 78.6 bits (192), Expect = 3e-14
Identities = 45/118 (38%), Positives = 65/118 (55%), Gaps = 9/118 (7%)
Query: 148 LRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSY 201
L G GL+N+GNTC++NA LQ LS+ PL F L + G R + + +++
Sbjct: 206 LLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAF 262
Query: 202 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQ 259
++ LWH +V PT + P+F GYSQQDAQEFL+ LM+ LH E+ +
Sbjct: 263 ADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR 320
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 111 bits (277), Expect = 3e-24
Identities = 61/169 (36%), Positives = 86/169 (50%), Gaps = 22/169 (13%)
Query: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 596
TL +C + ++L D+ + C C+ L+ G+ + P+IL IHLKRF
Sbjct: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
Query: 597 KISTHVSFPLEGLDLQPFLAKDS---------------PAQIVT-------YDLLSVICH 634
K+ST V FPL GL++ P +A+ S P + T YDL +V H
Sbjct: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
Query: 635 HGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 683
HG GHY AYCRN+L+ WY +DD +V + E V AY+LFY+K
Sbjct: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/112 (34%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 146 DELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLM 205
D R G GLKN GNTC+MNA +Q LSN L + FL G + + + L+
Sbjct: 93 DGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAALV 151
Query: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 257
LW + + + F+G SQ DA EFL L+D +HE+L+
Sbjct: 152 RALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 110 bits (275), Expect = 6e-24
Identities = 53/150 (35%), Positives = 84/150 (56%), Gaps = 1/150 (0%)
Query: 534 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 593
P V L+DC+ F +++L ++ + C CK+ + K + + P +L +HLKRF +
Sbjct: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
Query: 594 FSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNN 653
K+ T V FP+ LD+ FL + A Y+L++V H+G GHY A+ +N +
Sbjct: 815 MRDKLDTLVDFPINDLDMSEFLINPN-AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
Query: 654 LWYEFDDQSVTEVSESTVQNAEAYVLFYRK 683
WY FDD SV+ SE + + AYVLFY++
Sbjct: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
Score = 90.1 bits (222), Expect = 8e-18
Identities = 52/146 (35%), Positives = 75/146 (51%), Gaps = 14/146 (9%)
Query: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------KKPAICKSYLKLM 205
GL GL N+GNTC+MN+A+Q LSN PPLT++FL+ + + I KSY +L+
Sbjct: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
Query: 206 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE------- 258
++W + V P + P F GY QQD QE L L+D LHE+L
Sbjct: 318 KQMW-SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYI 376
Query: 259 QVMEVEEDPQTITTEETMEEDKSQSD 284
Q+ + + P + EE E ++D
Sbjct: 377 QLKDADGRPDKVVAEEAWENHLKRND 402
Score = 40.8 bits (94), Expect = 0.006
Identities = 19/46 (41%), Positives = 30/46 (65%)
Query: 438 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 483
K+ S+I DIF G S++ C C ++SVT + F L+LP+P K++
Sbjct: 399 KRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKE 444
Score = 33.9 bits (76), Expect = 0.71
Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 19/95 (20%)
Query: 798 EIFIRLNRAFQKEDSPATFYCISMQWFREWESFV------KGKDGDP---PGPIDNTKIA 848
+I L + +K D T+Y + +WF++W+ +V K + GD PGPIDN+
Sbjct: 15 DIATLLKTSLRKGD---TWYLVDSRWFKQWKKYVGFDSWDKYQMGDQNVYPGPIDNS--G 69
Query: 849 VTKCGNVM-----LRQGADSGQISEETWNFLQSIY 878
+ K G+ L D + E WN L S Y
Sbjct: 70 LLKDGDAQSLKEHLIDELDYILLPTEGWNKLVSWY 104
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 109 bits (273), Expect = 1e-23
Identities = 76/258 (29%), Positives = 109/258 (42%), Gaps = 44/258 (17%)
Query: 443 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 502
+I IF G + S V C C VS T++ D+SL +PG S +P S
Sbjct: 483 IIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS---CATFDSQNPERADSTVSR 539
Query: 503 GEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKC 562
+ + +PS L DCL F + L C C
Sbjct: 540 DDH------------------IPGIPS--------LTDCLQWFTRPEHLGSSAKIKCNSC 573
Query: 563 KKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQ 622
+ + K ++ P + C HLKRF H KI+T +SFPLE LD+ PFLA ++
Sbjct: 574 QSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE-LDMTPFLASTKESR 632
Query: 623 IV-------------TYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES 669
+ Y L +VI HHGT SGHY ++ R + W+ DD +T+ +
Sbjct: 633 MKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQ-KDQWFSCDDAIITKATIE 691
Query: 670 TVQNAEAYVLFYRKSSEE 687
+ +E Y+LFY K E
Sbjct: 692 DLLYSEGYLLFYHKQGLE 709
Score = 79.7 bits (195), Expect = 1e-14
Identities = 78/293 (26%), Positives = 119/293 (40%), Gaps = 47/293 (16%)
Query: 30 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYAC--- 86
C C L +CL C + GC + H H++ +H+L V+L ++C+ C
Sbjct: 236 CHVCSTHMNRLHSCLS--CVFFGCFTEKHIHK--HAETKQHHLAVDLYHGVIYCFMCKDY 291
Query: 87 ------------SKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAV 134
+KE L T + H Q + +D + T + P +
Sbjct: 292 VYDKDIEQIAKETKEKILRLLTSTSTDVSH----QQFMTSGFEDKQSTCETKEQEPKLVK 347
Query: 135 FDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK- 193
+ + + GL GL N+GNTC+MN +QAL++ P L FFL +DK
Sbjct: 348 ----PKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFL-------SDKH 396
Query: 194 -----KPAICKSYLKLMTELWHKSRPGS---VVPTTLFQGIKTVNPTFRGYSQQDAQEFL 245
P++C + M+ L+H GS +P L I GY QQDA EFL
Sbjct: 397 KCIMTSPSLC--LVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFL 454
Query: 246 RCLMDLLHEELKEQV--MEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNS 296
++D+LH K+ E + + QSDV Q+C S S +
Sbjct: 455 IAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTT 507
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 107 bits (266), Expect = 7e-23
Identities = 54/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 536 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 595
V LQ+C+ F + L+ +N + C CK+ + K + PEIL IHLKRF +
Sbjct: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
Query: 596 TKISTHVSFPLEGLDLQPFLAK---DSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLN 652
K+ T V FP+ LD F+ + +S ++ YDL++V H+G GHY + N +
Sbjct: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
Query: 653 NLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 683
W+ FDD SV+ V+E+ +++ AYVLFY++
Sbjct: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
Score = 80.1 bits (196), Expect = 9e-15
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 14/159 (8%)
Query: 139 DIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------ 192
++ ++ED G+ GL N+GNTC+MN+ALQ LSN P LT++FL+ L +
Sbjct: 294 NMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLG 353
Query: 193 KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLL 252
K I ++Y L+ + W S+VP + F GY Q D+QE L L+D L
Sbjct: 354 MKGEIAEAYADLVKQAW-SGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGL 412
Query: 253 HEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 284
HE+L ++ + P +E + K ++D
Sbjct: 413 HEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRND 451
Score = 39.3 bits (90), Expect = 0.017
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 421 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 479
P + AQ A K+++ SVI D F G S++ C C VSVT + F LS+P+P
Sbjct: 434 PDQEVAQEAWQNHKRRND---SVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
Score = 38.5 bits (88), Expect = 0.029
Identities = 20/72 (27%), Positives = 39/72 (54%), Gaps = 8/72 (11%)
Query: 815 TFYCISMQWFREWESFVKGKDGDP---PGPIDNTKIAVTKCGNVMLRQGADSGQ----IS 867
+++ + W+++WE++V+G D D PG I+N + + N L++G G+ +
Sbjct: 101 SWFLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEI-NWRLKEGLVEGEDYVLLP 159
Query: 868 EETWNFLQSIYG 879
W++L S YG
Sbjct: 160 AAAWHYLVSWYG 171
>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
Length = 1035
Score = 102 bits (255), Expect = 1e-21
Identities = 87/411 (21%), Positives = 169/411 (41%), Gaps = 80/411 (19%)
Query: 538 LQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKR--FRHELMFS 595
L DC++ F ++L+GDN Y CE C+ +N + ++ + P L + L R F +
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHK 308
Query: 596 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHG-TASSGHYIAYCRNNLNNL 654
K++T++ F E LD++P++ + + Y+L +V+ H G +A SGHYIA+ ++ +
Sbjct: 309 KKLNTYIGFS-EILDMEPYVEHKGGSYV--YELSAVLIHRGVSAYSGHYIAHVKDPQSGE 365
Query: 655 WYEFDDQSVTEVSESTVQ--------------------------NAEAYVLFYRKSSEEA 688
WY+F+D+ + ++ +Q + AY+L YR ++E
Sbjct: 366 WYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRKPKCGKGTHCSRNAYMLVYRLQTQEK 425
Query: 689 QKERRRISNLL-NIMEPSLLQF-------------------------------------- 709
++ L +++ +F
Sbjct: 426 PNTTVQVPAFLQELVDRDNSKFEEWCIEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEP 485
Query: 710 --YISRQWLNKFKTFAEP-GPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 766
++S +WL K+ + P PI N+ LC H + P K ++ + + D YSR
Sbjct: 486 YEFVSLEWLQKWLDESTPTKPIDNHACLCSHDKLHPDKI----SIMKRISEYAADIFYSR 541
Query: 767 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFRE 826
YGGGP + +C C +E +I + + E + +N + + + + R
Sbjct: 542 YGGGPRLTVKALCKECVVERCRILRLKNQLNEDYKTVNNLLKAAVKGSDGFWVGKSSLRS 601
Query: 827 WESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSI 877
W + + G + + + G+ + + + + EE NF + I
Sbjct: 602 WRQLALEQLDEQDGDAEQSNGKMN--GSTLNKDESKEERKEEEELNFNEDI 650
Score = 42.0 bits (97), Expect = 0.003
Identities = 34/122 (27%), Positives = 50/122 (40%), Gaps = 16/122 (13%)
Query: 149 RARGLTGLKNIGNTCYMNAALQ----------ALSNCPPL-TQFFLDCGGLARTDKKPAI 197
+ GL N+G TCY+N LQ AL CP + + L G D +P
Sbjct: 84 KKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEKDYEPQT 143
Query: 198 CKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 257
+L+ + L S + P+ + + QQDAQEF + M LL + L
Sbjct: 144 ICEHLQYLFALLQNSNRRYIDPSGFVKALGLDTG-----QQQDAQEFSKLFMSLLEDTLS 198
Query: 258 EQ 259
+Q
Sbjct: 199 KQ 200
>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 99.8 bits (247), Expect = 1e-20
Identities = 74/272 (27%), Positives = 118/272 (43%), Gaps = 61/272 (22%)
Query: 433 RKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSH 492
++K K+ +V+++IF G ++S V CL CD S T+E F DLSL P + + +S
Sbjct: 454 QRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKDIASQ 513
Query: 493 PTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELK 552
P + + LA F + L+
Sbjct: 514 PCLVT------------------------------------------EMLAKFTETEALE 531
Query: 553 GDNMYSCEKCKKLRN-----------GVKFCKVQNFPEILCIHLKRFRHELMFST-KIST 600
G +Y C++C R K + + P++L +HLKRFR + KI
Sbjct: 532 G-KIYVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGV 590
Query: 601 HVSFPLEGLDLQPFLAKDSPAQI----VTYDLLSVICHHGTA-SSGHYIAYCRNNLNNLW 655
HV F E L+++P+ +++ + YDL +V+ HHG SGHY AYC N+ W
Sbjct: 591 HVGFE-EILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFW 649
Query: 656 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEE 687
+D ++ + V A+AY+LFY + E
Sbjct: 650 VHCNDSKLSMCTMDEVCKAQAYILFYTQRVTE 681
Score = 53.1 bits (126), Expect = 1e-06
Identities = 51/170 (30%), Positives = 67/170 (39%), Gaps = 64/170 (37%)
Query: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFL----------DCGGLARTDKKPAICKSY 201
G+TGL+N+GNTCYMN+ LQ LS+ Q FL R+ K P + +
Sbjct: 271 GVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTV 330
Query: 202 LKLMTELWHK------SRPGSV--------------------VPT-----------TLFQ 224
+ M E K SR S+ PT TLFQ
Sbjct: 331 VYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQ 390
Query: 225 -----------------GIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 257
+ + P FRGY+QQDAQEFL L+D + EL+
Sbjct: 391 VMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRELE 440
Score = 52.0 bits (123), Expect = 3e-06
Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 8 CPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQE 67
C H+ + + C DC ++WACL CS+V CG +H+ H QE
Sbjct: 7 CKHVGQLQLAQDHSSLNPQKWHCVDCNTT-ESIWACLS--CSHVACGRYIEEHALKHFQE 63
Query: 68 TKHYLTVNLTTLRVWCYACSKEVFLDRKLG 97
+ H + + + + V+CY C V D G
Sbjct: 64 SSHPVALEVNEMYVFCYLCDDYVLNDNTTG 93
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/165 (35%), Positives = 82/165 (49%), Gaps = 8/165 (4%)
Query: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFR-HELMFS 595
TL CL F + L + + C +CK+ R K + P +L + LKRF ++
Sbjct: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
Query: 596 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR--NNLNN 653
KI+ V FP+ LDL F Q+ +YDL +VI H+G GHY A R N+ ++
Sbjct: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
Query: 654 L-----WYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERR 693
W FDD +VT V ES V AYVLFYR+ + ++ R
Sbjct: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
Score = 78.6 bits (192), Expect = 3e-14
Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 136 DDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKK- 194
D ++ E +EE ++ G TGL N+GNTC+MN+ +Q+LSN L FF D A +
Sbjct: 479 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 538
Query: 195 -----PAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 249
+ + L+ LW K + P+ L + + F GY+Q DAQEF+ L+
Sbjct: 539 PLGTGGRLAIGFAVLLRALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLL 597
Query: 250 DLLHEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 284
D LHE+L + ++ + P + EE + K ++D
Sbjct: 598 DGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRND 639
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 435 KQHK-KYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKE 482
++HK + S I D+F G S + C C +VS+T + F L +P+P K+
Sbjct: 632 QRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 90.1 bits (222), Expect = 8e-18
Identities = 98/402 (24%), Positives = 159/402 (39%), Gaps = 65/402 (16%)
Query: 19 KEDLIQKSLGTCQDCKVQG-------------PNLWACLENRCSYVGCGE-SQVDHSTIH 64
K+ L+ CQDCK P++W CL +C + GCG SQ H+ H
Sbjct: 37 KKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCL--KCGHQGCGRNSQEQHALKH 94
Query: 65 ---SQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI 121
+ H L ++L VWCY C EV + +VR+ I + K
Sbjct: 95 YLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPE--KD 152
Query: 122 PSNTTLKTPLVAVFDDLDIEADEEDELRARG----------LTGLKNIGNTCYMNAALQA 171
N L+ + + E ++++ + + GL N+GNTC+ NA +Q
Sbjct: 153 NGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQN 212
Query: 172 LSNCPPLTQFF-----------LDCGGLARTD------KKPAICKSYLKLMTELWHKSRP 214
LS P L + ++ LA T+ + P + +++
Sbjct: 213 LSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKK 272
Query: 215 GSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEE 274
G V P LF + F+GY QQD+QE LR L+D + E ++V + +TE+
Sbjct: 273 GVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEK 332
Query: 275 TMEEDKSQSDVDFQSCESC-SNSDRAENENGSRCFSEDNNETTMLIQ-----------DD 322
EE K++ D++ +S S DR + D T L+ DD
Sbjct: 333 LDEELKNKVK-DYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDD 391
Query: 323 ENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDS-ISETVDL 363
++ + D +K + + + E +KD DS I E D+
Sbjct: 392 QSGKKSVNDKNLKK---TVEDEDQDSEEEKDNDSYIKERSDI 430
Score = 75.1 bits (183), Expect = 3e-13
Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 49/193 (25%)
Query: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLR-----------------NGVKFCKVQNFPE 579
++Q CL F ++L+ N CE C + + N K + P
Sbjct: 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 690
Query: 580 ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPF-------LAKDSPAQIVTYDLLSVI 632
+L +HLKRF+ K++ H+ FP E LDL PF +A+++ V Y L V+
Sbjct: 691 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVV 747
Query: 633 CHHGTASSGHYIAYCR-----NNLNNL-----------------WYEFDDQSVTEVSEST 670
H GT SGHY AY + ++L+NL W+ D V V +
Sbjct: 748 EHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTK 807
Query: 671 VQNAEAYVLFYRK 683
V N++AY+LFY +
Sbjct: 808 VLNSQAYLLFYER 820
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 432 KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPI 478
K ++ K S + IF G + S + C C VS+ E+F DLSLP+
Sbjct: 342 KDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 388
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 90.1 bits (222), Expect = 8e-18
Identities = 98/402 (24%), Positives = 159/402 (39%), Gaps = 64/402 (15%)
Query: 19 KEDLIQKSLGTCQDCKVQG-------------PNLWACLENRCSYVGCGE-SQVDHSTIH 64
K+ L+ CQDCK P++W CL +C + GCG SQ H+ H
Sbjct: 37 KKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCL--KCGHQGCGRNSQEQHALKH 94
Query: 65 ---SQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI 121
+ H L ++L VWCY C EV + +VR+ I + K
Sbjct: 95 YLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAE-KD 153
Query: 122 PSNTTLKTPLVAVFDDLDIEADEEDELRARG----------LTGLKNIGNTCYMNAALQA 171
N L+ + + E ++++ + + GL N+GNTC+ NA +Q
Sbjct: 154 NGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQN 213
Query: 172 LSNCPPLTQFF-----------LDCGGLARTD------KKPAICKSYLKLMTELWHKSRP 214
LS P L + ++ LA T+ + P + +++
Sbjct: 214 LSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKK 273
Query: 215 GSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEE 274
G V P LF + F+GY QQD+QE LR L+D + E ++V + +TE+
Sbjct: 274 GVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEK 333
Query: 275 TMEEDKSQSDVDFQSCESC-SNSDRAENENGSRCFSEDNNETTMLIQ-----------DD 322
EE K++ D++ +S S DR + D T L+ DD
Sbjct: 334 LDEELKNKVK-DYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDD 392
Query: 323 ENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDS-ISETVDL 363
++ + D +K + + + E +KD DS I E D+
Sbjct: 393 QSGKKSVNDKNLKK---TVEDEDQDSEEEKDNDSYIKERSDI 431
Score = 75.1 bits (183), Expect = 3e-13
Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 49/193 (25%)
Query: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLR-----------------NGVKFCKVQNFPE 579
++Q CL F ++L+ N CE C + + N K + P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
Query: 580 ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPF-------LAKDSPAQIVTYDLLSVI 632
+L +HLKRF+ K++ H+ FP E LDL PF +A+++ V Y L V+
Sbjct: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVV 748
Query: 633 CHHGTASSGHYIAYCR-----NNLNNL-----------------WYEFDDQSVTEVSEST 670
H GT SGHY AY + ++L+NL W+ D V V +
Sbjct: 749 EHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTK 808
Query: 671 VQNAEAYVLFYRK 683
V N++AY+LFY +
Sbjct: 809 VLNSQAYLLFYER 821
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 432 KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPI 478
K ++ K S + IF G + S + C C VS+ E+F DLSLP+
Sbjct: 343 KDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 90.1 bits (222), Expect = 8e-18
Identities = 98/402 (24%), Positives = 159/402 (39%), Gaps = 64/402 (15%)
Query: 19 KEDLIQKSLGTCQDCKVQG-------------PNLWACLENRCSYVGCGE-SQVDHSTIH 64
K+ L+ CQDCK P++W CL +C + GCG SQ H+ H
Sbjct: 37 KKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCL--KCGHQGCGRNSQEQHALKH 94
Query: 65 ---SQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI 121
+ H L ++L VWCY C EV + +VR+ I + K
Sbjct: 95 YLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAE-KD 153
Query: 122 PSNTTLKTPLVAVFDDLDIEADEEDELRARG----------LTGLKNIGNTCYMNAALQA 171
N L+ + + E ++++ + + GL N+GNTC+ NA +Q
Sbjct: 154 NGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQN 213
Query: 172 LSNCPPLTQFF-----------LDCGGLARTD------KKPAICKSYLKLMTELWHKSRP 214
LS P L + ++ LA T+ + P + +++
Sbjct: 214 LSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKK 273
Query: 215 GSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEE 274
G V P LF + F+GY QQD+QE LR L+D + E ++V + +TE+
Sbjct: 274 GVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEK 333
Query: 275 TMEEDKSQSDVDFQSCESC-SNSDRAENENGSRCFSEDNNETTMLIQ-----------DD 322
EE K++ D++ +S S DR + D T L+ DD
Sbjct: 334 LDEELKNKVK-DYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDD 392
Query: 323 ENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDS-ISETVDL 363
++ + D +K + + + E +KD DS I E D+
Sbjct: 393 QSGKKSVNDKNLKK---TVEDEDQDSEEEKDNDSYIKERSDI 431
Score = 75.1 bits (183), Expect = 3e-13
Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 49/193 (25%)
Query: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLR-----------------NGVKFCKVQNFPE 579
++Q CL F ++L+ N CE C + + N K + P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
Query: 580 ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPF-------LAKDSPAQIVTYDLLSVI 632
+L +HLKRF+ K++ H+ FP E LDL PF +A+++ V Y L V+
Sbjct: 692 VLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVV 748
Query: 633 CHHGTASSGHYIAYCR-----NNLNNL-----------------WYEFDDQSVTEVSEST 670
H GT SGHY AY + ++L+NL W+ D V V +
Sbjct: 749 EHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTK 808
Query: 671 VQNAEAYVLFYRK 683
V N++AY+LFY +
Sbjct: 809 VLNSQAYLLFYER 821
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 432 KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPI 478
K ++ K S + IF G + S + C C VS+ E+F DLSLP+
Sbjct: 343 KDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPV 389
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,266,190
Number of Sequences: 37866
Number of extensions: 1819274
Number of successful extensions: 7728
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 6812
Number of HSP's gapped (non-prelim): 715
length of query: 911
length of database: 18,247,518
effective HSP length: 111
effective length of query: 800
effective length of database: 14,044,392
effective search space: 11235513600
effective search space used: 11235513600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.