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Search of human proteins with 42516561
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo
sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 1706 0.0
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 1695 0.0
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 1634 0.0
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 949 0.0
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 949 0.0
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 949 0.0
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 141 3e-33
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 138 2e-32
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 138 2e-32
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 138 2e-32
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 136 7e-32
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 136 7e-32
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 134 3e-31
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 134 3e-31
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 134 3e-31
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens] 134 3e-31
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 124 3e-28
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 122 1e-27
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 118 3e-26
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 118 3e-26
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 118 3e-26
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 118 3e-26
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 118 3e-26
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 112 2e-24
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 111 3e-24
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 110 5e-24
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 107 6e-23
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens] 102 1e-21
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] 98 3e-20
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 95 3e-19
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 1706 bits (4419), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MTGSNSHITILTLKVLPHFESLGKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGT 60
MTGSNSHITILTLKVLPHFESLGKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGT
Sbjct: 1 MTGSNSHITILTLKVLPHFESLGKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGT 60
Query: 61 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE 120
CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE
Sbjct: 61 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE 120
Query: 121 VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR 180
VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR
Sbjct: 121 VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR 180
Query: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELW 240
ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELW
Sbjct: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELW 240
Query: 241 HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQT 300
HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQT
Sbjct: 241 HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQT 300
Query: 301 ITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMS 360
ITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMS
Sbjct: 301 ITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMS 360
Query: 361 KDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDL 420
KDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDL
Sbjct: 361 KDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDL 420
Query: 421 STPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFD 480
STPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFD
Sbjct: 421 STPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFD 480
Query: 481 GTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQ 540
GTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQ
Sbjct: 481 GTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQ 540
Query: 541 GWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNF 600
GWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNF
Sbjct: 541 GWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNF 600
Query: 601 PEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGT 660
PEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGT
Sbjct: 601 PEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGT 660
Query: 661 ASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISN 720
ASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISN
Sbjct: 661 ASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISN 720
Query: 721 LLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQ 780
LLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQ
Sbjct: 721 LLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQ 780
Query: 781 NIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK 828
NIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK
Sbjct: 781 NIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK 828
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 1695 bits (4389), Expect = 0.0
Identities = 825/836 (98%), Positives = 827/836 (98%), Gaps = 8/836 (0%)
Query: 1 MTGSNSHITILTLKVLPHFESLGKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGT 60
MTGSNSHITILTLKVLPHFESLGKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGT
Sbjct: 1 MTGSNSHITILTLKVLPHFESLGKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGT 60
Query: 61 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE 120
CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE
Sbjct: 61 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE 120
Query: 121 VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR 180
VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR
Sbjct: 121 VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR 180
Query: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELW 240
ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELW
Sbjct: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELW 240
Query: 241 HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQT 300
HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQT
Sbjct: 241 HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQT 300
Query: 301 ITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMS 360
ITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMS
Sbjct: 301 ITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMS 360
Query: 361 KDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDL 420
KDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDL
Sbjct: 361 KDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDL 420
Query: 421 STPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFD 480
STPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFD
Sbjct: 421 STPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFD 480
Query: 481 GTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQ 540
GTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQ
Sbjct: 481 GTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQ 540
Query: 541 GWIAFFMEYVK--------SWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGV 592
GWIAFFMEYVK SWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGV
Sbjct: 541 GWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGV 600
Query: 593 KFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLL 652
KFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLL
Sbjct: 601 KFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLL 660
Query: 653 SVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQ 712
SVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQ
Sbjct: 661 SVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQ 720
Query: 713 KERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIE 772
KERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIE
Sbjct: 721 KERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIE 780
Query: 773 DLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK 828
DLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIR+ +
Sbjct: 781 DLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNR 836
Score = 35.0 bits (79), Expect = 0.29
Identities = 31/103 (30%), Positives = 42/103 (40%), Gaps = 19/103 (18%)
Query: 710 EAQKERRRISNLLNIM---------EPSLLQFY-ISRQWLNKFKTFAE------PGPISN 753
EA+K +R L I E S FY IS QW ++++F + PGPI N
Sbjct: 816 EAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDN 875
Query: 754 NDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV 796
G + G + + W+ L S YGGGP V
Sbjct: 876 TKIAVTKCGNVMLRQGADSG---QISEETWNFLQSIYGGGPEV 915
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 1634 bits (4230), Expect = 0.0
Identities = 794/805 (98%), Positives = 796/805 (98%), Gaps = 8/805 (0%)
Query: 32 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91
MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH
Sbjct: 1 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 60
Query: 92 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151
STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK
Sbjct: 61 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 120
Query: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211
IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ
Sbjct: 121 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 180
Query: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD
Sbjct: 181 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 240
Query: 272 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 331
AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE
Sbjct: 241 AQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAE 300
Query: 332 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 391
NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET
Sbjct: 301 NENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISET 360
Query: 392 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 451
VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA
Sbjct: 361 VDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLA 420
Query: 452 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 511
PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG
Sbjct: 421 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPG 480
Query: 512 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK--------SWFWGPVVTLQD 563
KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK SWFWGPVVTLQD
Sbjct: 481 KEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQD 540
Query: 564 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 623
CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST
Sbjct: 541 CLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKIST 600
Query: 624 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 683
HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD
Sbjct: 601 HVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDD 660
Query: 684 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 743
QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK
Sbjct: 661 QSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFK 720
Query: 744 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 803
TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH
Sbjct: 721 TFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICH 780
Query: 804 TCQIEAEKIEKRRKTELEIFIRVKK 828
TCQIEAEKIEKRRKTELEIFIR+ +
Sbjct: 781 TCQIEAEKIEKRRKTELEIFIRLNR 805
Score = 35.0 bits (79), Expect = 0.29
Identities = 31/103 (30%), Positives = 42/103 (40%), Gaps = 19/103 (18%)
Query: 710 EAQKERRRISNLLNIM---------EPSLLQFY-ISRQWLNKFKTFAE------PGPISN 753
EA+K +R L I E S FY IS QW ++++F + PGPI N
Sbjct: 785 EAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDN 844
Query: 754 NDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV 796
G + G + + W+ L S YGGGP V
Sbjct: 845 TKIAVTKCGNVMLRQGADSG---QISEETWNFLQSIYGGGPEV 884
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 949 bits (2454), Expect = 0.0
Identities = 477/819 (58%), Positives = 597/819 (72%), Gaps = 35/819 (4%)
Query: 32 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91
M R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+ C YVGCGES DH
Sbjct: 1 MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
Query: 92 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151
STIH+Q KH LTVNLTT R+WCYAC KEVFL+++L P + + E QD
Sbjct: 61 STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
Query: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211
PS+ LK +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP VVPT+L GIK VNP FRGY+QQD
Sbjct: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
Query: 272 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 326
QEFLRCLMD LHEELKE V+ D + T+E E D+S S+ +F SC+S +
Sbjct: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
Query: 327 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 386
SDR E + R ET +LI D+ + K+ K++ + + + + D+D D
Sbjct: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
Query: 387 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 440
+ L++Q R+S E D H S P + + +LS+SP
Sbjct: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
Query: 441 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 497
P++ + +AP + KKAQ S R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS
Sbjct: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
Query: 498 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK------ 551
T+ETFQDLSLPIPGKEDLAKLHS+ + K G+CG++YA QGW+AF +EY++
Sbjct: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
Query: 552 --SWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 609
SWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV PEILCIHLK
Sbjct: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
Query: 610 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 669
RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+ +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
Query: 670 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 729
C+N +N WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L + EPSL
Sbjct: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
Query: 730 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 789
L+FY+SR+WLNKF TFAEPGPI+N FLC HGG+PP K YI+DLV++LPQN+W++LY+R
Sbjct: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
Query: 790 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK 828
+GGGPAVNHLY+C CQ+E E + KRR+ E++ FI++ K
Sbjct: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNK 806
Score = 32.7 bits (73), Expect = 1.4
Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 18/102 (17%)
Query: 710 EAQKERRRI--------SNLLNIMEPSLLQFYISRQWLNKFKTFAE------PGPISNND 755
EA +RRRI + E + + IS QW +++ F + PGPI N+
Sbjct: 788 EALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPPGPIDNSR 847
Query: 756 FLCIHG-GVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV 796
+ G G K G + + W L S YGGGP +
Sbjct: 848 IAQVKGSGHVQLKQGADYG---QISEETWTYLNSLYGGGPEI 886
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 949 bits (2454), Expect = 0.0
Identities = 477/819 (58%), Positives = 597/819 (72%), Gaps = 35/819 (4%)
Query: 32 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91
M R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+ C YVGCGES DH
Sbjct: 1 MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
Query: 92 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151
STIH+Q KH LTVNLTT R+WCYAC KEVFL+++L P + + E QD
Sbjct: 61 STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
Query: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211
PS+ LK +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP VVPT+L GIK VNP FRGY+QQD
Sbjct: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
Query: 272 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 326
QEFLRCLMD LHEELKE V+ D + T+E E D+S S+ +F SC+S +
Sbjct: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
Query: 327 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 386
SDR E + R ET +LI D+ + K+ K++ + + + + D+D D
Sbjct: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
Query: 387 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 440
+ L++Q R+S E D H S P + + +LS+SP
Sbjct: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
Query: 441 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 497
P++ + +AP + KKAQ S R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS
Sbjct: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
Query: 498 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK------ 551
T+ETFQDLSLPIPGKEDLAKLHS+ + K G+CG++YA QGW+AF +EY++
Sbjct: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
Query: 552 --SWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 609
SWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV PEILCIHLK
Sbjct: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
Query: 610 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 669
RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+ +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
Query: 670 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 729
C+N +N WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L + EPSL
Sbjct: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
Query: 730 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 789
L+FY+SR+WLNKF TFAEPGPI+N FLC HGG+PP K YI+DLV++LPQN+W++LY+R
Sbjct: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
Query: 790 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK 828
+GGGPAVNHLY+C CQ+E E + KRR+ E++ FI++ K
Sbjct: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNK 806
Score = 32.7 bits (73), Expect = 1.4
Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 18/102 (17%)
Query: 710 EAQKERRRI--------SNLLNIMEPSLLQFYISRQWLNKFKTFAE------PGPISNND 755
EA +RRRI + E + + IS QW +++ F + PGPI N+
Sbjct: 788 EALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPPGPIDNSR 847
Query: 756 FLCIHG-GVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV 796
+ G G K G + + W L S YGGGP +
Sbjct: 848 IAQVKGSGHVQLKQGADYG---QISEETWTYLNSLYGGGPEI 886
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 949 bits (2454), Expect = 0.0
Identities = 477/819 (58%), Positives = 597/819 (72%), Gaps = 35/819 (4%)
Query: 32 MSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDH 91
M R+ CPHLDS+GE+TKEDL+ KS GTCQ C V GPNLWACL+ C YVGCGES DH
Sbjct: 1 MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADH 60
Query: 92 STIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFK 151
STIH+Q KH LTVNLTT R+WCYAC KEVFL+++L P + + E QD
Sbjct: 61 STIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQRLAA----PLLGSSSKFSE---QDSP 113
Query: 152 IPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQ 211
PS+ LK +AV D+ + E+ E+D+L+ RGLTG+KN+GN+CYMNAALQALSNCPPLTQ
Sbjct: 114 PPSHP-LKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQ 171
Query: 212 FFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
FFL+CGGL RTDKKPA+CKSY KL++E+WHK RP VVPT+L GIK VNP FRGY+QQD
Sbjct: 172 FFLECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
Query: 272 AQEFLRCLMDLLHEELKEQVMEV-----EEDPQTITTEETMEEDKSQSDVDFQSCESCSN 326
QEFLRCLMD LHEELKE V+ D + T+E E D+S S+ +F SC+S +
Sbjct: 232 TQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEKREGDRSPSEDEFLSCDS--S 289
Query: 327 SDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRD 386
SDR E + R ET +LI D+ + K+ K++ + + + + D+D D
Sbjct: 290 SDRGEGDGQGRGGGSSQAETELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDAD 349
Query: 387 SISETVDLNNQETVKVQIHSRAS------EYITDVHSNDLSTPQILPSNEGVNPRLSASP 440
+ L++Q R+S E D H S P + + +LS+SP
Sbjct: 350 VDTAMAALDDQPAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSP 409
Query: 441 PKSGNLWPGLAPPH--KKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSV 497
P++ + +AP + KKAQ S R+++ ++YRSVISDIFDG+I+S VQCLTCDRVS
Sbjct: 410 PRASPV--RMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVST 467
Query: 498 TLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVK------ 551
T+ETFQDLSLPIPGKEDLAKLHS+ + K G+CG++YA QGW+AF +EY++
Sbjct: 468 TVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSC 527
Query: 552 --SWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 609
SWFWGPVVTL+DCLAAFFA DELKGDNMYSCE+CKKLRNGVK+CKV PEILCIHLK
Sbjct: 528 TPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
Query: 610 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAY 669
RFRHE+M+S KI++HVSFPLEGLDL+PFLAK+ +QI TYDLLSVICHHGTA SGHYIAY
Sbjct: 588 RFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAY 647
Query: 670 CRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSL 729
C+N +N WYEFDDQ VTEV E+ VQNAE YVLFYRKSSEEA +ER+++ +L + EPSL
Sbjct: 648 CQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMREPSL 707
Query: 730 LQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 789
L+FY+SR+WLNKF TFAEPGPI+N FLC HGG+PP K YI+DLV++LPQN+W++LY+R
Sbjct: 708 LRFYVSREWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNR 767
Query: 790 YGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRVKK 828
+GGGPAVNHLY+C CQ+E E + KRR+ E++ FI++ K
Sbjct: 768 FGGGPAVNHLYVCSICQVEIEALAKRRRIEIDTFIKLNK 806
Score = 32.7 bits (73), Expect = 1.4
Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 18/102 (17%)
Query: 710 EAQKERRRI--------SNLLNIMEPSLLQFYISRQWLNKFKTFAE------PGPISNND 755
EA +RRRI + E + + IS QW +++ F + PGPI N+
Sbjct: 788 EALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKGKDNEPPGPIDNSR 847
Query: 756 FLCIHG-GVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV 796
+ G G K G + + W L S YGGGP +
Sbjct: 848 IAQVKGSGHVQLKQGADYG---QISEETWTYLNSLYGGGPEI 886
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 141 bits (355), Expect = 3e-33
Identities = 83/246 (33%), Positives = 123/246 (50%), Gaps = 37/246 (15%)
Query: 473 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGS 532
+V++ IF G + + V CL C S + F DLSL IP +
Sbjct: 308 TVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQ-------------------- 347
Query: 533 CGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGV 592
F + K+ GPV +L+DCL +F +EL +Y C KCKK +
Sbjct: 348 ------------FRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKST 395
Query: 593 KFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFL--AKDSPAQIVTYD 650
K +Q P++LC+HLKRF K+ T+V FPL GLD++ +L ++S + YD
Sbjct: 396 KKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYD 455
Query: 651 LLSVICHHGT-ASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSE 709
L +V+ HHG+ SGHY AY + W+ F+D +VT E TV A+AY+LFY +
Sbjct: 456 LAAVVVHHGSGVGSGHYTAYATH--EGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQA 513
Query: 710 EAQKER 715
+A ++
Sbjct: 514 KAGSDK 519
Score = 101 bits (251), Expect = 3e-21
Identities = 84/292 (28%), Positives = 126/292 (43%), Gaps = 59/292 (20%)
Query: 39 CPHLDSVGEITKEDLI----QKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTI 94
CPHL S I + S C C+ + W CL CS V CG H+
Sbjct: 3 CPHLSSSVCIAPDSAKFPNGSPSSWCCSVCR-SNKSPWVCLT--CSSVHCGRYVNGHAKK 59
Query: 95 HSQETK----------------HYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQ 138
H ++ + H + ++ ++ +CY C V D KLG + VR+
Sbjct: 60 HYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGL---VQKVRE 116
Query: 139 PHQIQENSV------QDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGN 192
Q ENS + K+ N+TL + L+ V A TGL+N+GN
Sbjct: 117 HLQNLENSAFTADRHKKRKLLENSTLNSKLLKV----------NGSTTAICATGLRNLGN 166
Query: 193 TCYMNAALQALSNCPPLTQFFLDCGGL----------------ARTDKKPAICKSYLKLM 236
TC+MNA LQ+LSN +F + + ++ D ++ + + K +
Sbjct: 167 TCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTL 226
Query: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 288
LW S+ + P +LF + + P FRGY QQDA EF+R L+D LH EL+
Sbjct: 227 CALWQGSQT-AFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQ 277
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 138 bits (347), Expect = 2e-32
Identities = 81/250 (32%), Positives = 121/250 (48%), Gaps = 48/250 (19%)
Query: 455 KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
K A+ A K K+ ++ S+I +F G S+VQCLTC + S T E F LSLP+
Sbjct: 905 KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL----- 956
Query: 515 LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDEL 574
C TLQDCL F ++L
Sbjct: 957 -------------ASTSKC--------------------------TLQDCLRLFSKEEKL 977
Query: 575 KGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDL 634
+N + C C+ R+ +K ++ P +L +HLKRF ++ + K+ T V FPLE LDL
Sbjct: 978 TDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDL 1037
Query: 635 QPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTV 694
++ + Y+L SV H+G GHY AYC+N W++FDD V+++S S+V
Sbjct: 1038 SQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSV 1096
Query: 695 QNAEAYVLFY 704
+++ AY+LFY
Sbjct: 1097 KSSAAYILFY 1106
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)
Query: 184 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 237
LTGL+N+GNTCYMN+ LQ L N P L +F D K + + + +M
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 238 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289
LW + + P I +N F GYSQQD+QE L LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 138 bits (347), Expect = 2e-32
Identities = 81/250 (32%), Positives = 121/250 (48%), Gaps = 48/250 (19%)
Query: 455 KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
K A+ A K K+ ++ S+I +F G S+VQCLTC + S T E F LSLP+
Sbjct: 905 KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL----- 956
Query: 515 LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDEL 574
C TLQDCL F ++L
Sbjct: 957 -------------ASTSKC--------------------------TLQDCLRLFSKEEKL 977
Query: 575 KGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDL 634
+N + C C+ R+ +K ++ P +L +HLKRF ++ + K+ T V FPLE LDL
Sbjct: 978 TDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDL 1037
Query: 635 QPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTV 694
++ + Y+L SV H+G GHY AYC+N W++FDD V+++S S+V
Sbjct: 1038 SQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSV 1096
Query: 695 QNAEAYVLFY 704
+++ AY+LFY
Sbjct: 1097 KSSAAYILFY 1106
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)
Query: 184 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 237
LTGL+N+GNTCYMN+ LQ L N P L +F D K + + + +M
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 238 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289
LW + + P I +N F GYSQQD+QE L LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 138 bits (347), Expect = 2e-32
Identities = 81/250 (32%), Positives = 121/250 (48%), Gaps = 48/250 (19%)
Query: 455 KKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
K A+ A K K+ ++ S+I +F G S+VQCLTC + S T E F LSLP+
Sbjct: 905 KAAEHAWQKHKQLNE---SIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL----- 956
Query: 515 LAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDEL 574
C TLQDCL F ++L
Sbjct: 957 -------------ASTSKC--------------------------TLQDCLRLFSKEEKL 977
Query: 575 KGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDL 634
+N + C C+ R+ +K ++ P +L +HLKRF ++ + K+ T V FPLE LDL
Sbjct: 978 TDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDL 1037
Query: 635 QPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTV 694
++ + Y+L SV H+G GHY AYC+N W++FDD V+++S S+V
Sbjct: 1038 SQYVI-GPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSV 1096
Query: 695 QNAEAYVLFY 704
+++ AY+LFY
Sbjct: 1097 KSSAAYILFY 1106
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 7/112 (6%)
Query: 184 LTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSYLKLMT 237
LTGL+N+GNTCYMN+ LQ L N P L +F D K + + + +M
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 238 ELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289
LW + + P I +N F GYSQQD+QE L LMD LHE+L +
Sbjct: 836 ALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNK 886
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 136 bits (343), Expect = 7e-32
Identities = 82/244 (33%), Positives = 123/244 (50%), Gaps = 44/244 (18%)
Query: 465 KKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHP 524
+K ++ S I D+F G + SS+ C C S + F DLSLPI
Sbjct: 192 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 236
Query: 525 TSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEK 584
A +G+ P VTL DC+ F D L GD +C +
Sbjct: 237 -------------AKRGY--------------PEVTLMDCMRLFTKEDVLDGDEKPTCCR 269
Query: 585 CKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA 644
C+ + +K +Q FP+IL +HLKRF + ++K++T V+FPL LDL+ F ++++
Sbjct: 270 CRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNH 329
Query: 645 QIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFY 704
+ Y+L +V H GT GHY AYCR+ W+ F+D SVT +S S V+ ++AY+LFY
Sbjct: 330 AV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFY 387
Query: 705 RKSS 708
+S
Sbjct: 388 ELAS 391
Score = 84.7 bits (208), Expect = 3e-16
Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%)
Query: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC--------GGLARTDKKPAICKSY 232
A+GL GL+N+GNTC+MN+ LQ LSN L + L G A T A+ + +
Sbjct: 54 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT----ALVEEF 109
Query: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVM 292
KL+ +W S V P+ I+ P F GY+QQDAQEFLR L+D LH E+ +
Sbjct: 110 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 169
Query: 293 EVEEDPQTI 301
+ +P+ +
Sbjct: 170 RPKSNPENL 178
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 136 bits (343), Expect = 7e-32
Identities = 82/244 (33%), Positives = 123/244 (50%), Gaps = 44/244 (18%)
Query: 465 KKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHP 524
+K ++ S I D+F G + SS+ C C S + F DLSLPI
Sbjct: 401 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 445
Query: 525 TSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEK 584
A +G+ P VTL DC+ F D L GD +C +
Sbjct: 446 -------------AKRGY--------------PEVTLMDCMRLFTKEDVLDGDEKPTCCR 478
Query: 585 CKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA 644
C+ + +K +Q FP+IL +HLKRF + ++K++T V+FPL LDL+ F ++++
Sbjct: 479 CRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNH 538
Query: 645 QIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFY 704
+ Y+L +V H GT GHY AYCR+ W+ F+D SVT +S S V+ ++AY+LFY
Sbjct: 539 AV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFY 596
Query: 705 RKSS 708
+S
Sbjct: 597 ELAS 600
Score = 84.7 bits (208), Expect = 3e-16
Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%)
Query: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC--------GGLARTDKKPAICKSY 232
A+GL GL+N+GNTC+MN+ LQ LSN L + L G A T A+ + +
Sbjct: 263 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT----ALVEEF 318
Query: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVM 292
KL+ +W S V P+ I+ P F GY+QQDAQEFLR L+D LH E+ +
Sbjct: 319 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 378
Query: 293 EVEEDPQTI 301
+ +P+ +
Sbjct: 379 RPKSNPENL 387
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 134 bits (337), Expect = 3e-31
Identities = 178/829 (21%), Positives = 313/829 (37%), Gaps = 161/829 (19%)
Query: 23 GKQEKIPNKMSAFRNHCPHLDSVGEI--TKEDLIQKSLGTCQDCKVQG------------ 68
GK I + C H+ E K+ L+ CQDCK
Sbjct: 8 GKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEE 67
Query: 69 -PNLWACLENRCSYVGCGE-SQVDHSTIH---SQETKHYLTVNLTTLRVWCYACSKEVFL 123
P++W CL +C + GCG SQ H+ H + H L ++L VWCY C EV
Sbjct: 68 KPSVWLCL--KCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQY 125
Query: 124 DRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARG 183
+ +VR+ I + K N L+ + + E ++++ +
Sbjct: 126 CSSNQLGQVVDYVRKQASITTPKPE--KDNGNIELENKKLEKESKNEQEREKKENMAKEN 183
Query: 184 ----------LTGLKNIGNTCYMNAALQALSNCPPLTQFF-----------LDCGGLART 222
+ GL N+GNTC+ NA +Q LS P L + ++ LA T
Sbjct: 184 PPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALT 243
Query: 223 D------KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFL 276
+ + P + +++ G V P LF + F+GY QQD+QE L
Sbjct: 244 EPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELL 303
Query: 277 RCLMD-----------------------LLHEELKEQVMEVEEDPQTITTEETMEEDKSQ 313
R L+D L EELK +V + E+ + + + +
Sbjct: 304 RYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELT 363
Query: 314 SDVDFQSCESCSNSDRA---------ENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQ 364
S + C + S + ++++G + ++ N + T+ +D ++ E D
Sbjct: 364 SMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSY 423
Query: 365 KEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQI----------HSRASEYITD 414
++ + + + + + + + + Q+ ++ ++ H SEY +
Sbjct: 424 IKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSEYEAE 483
Query: 415 VH-SNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRS 473
+ +++ S EGV + K N G A K +S + +K +
Sbjct: 484 MSLQGEVNIKSNHISQEGVMHKEYCVNQKDLN---GQA---KMIESVTDNQKSTEEVDMK 537
Query: 474 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533
I+ D +++S + +T + ++ + K L+++ HP I
Sbjct: 538 NINMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKN--LNLNAALHPDEI-NIEIL 594
Query: 534 GEAYAPQGWI----------AFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCE 583
+++ P + AF + F ++Q CL F ++L+ N CE
Sbjct: 595 NDSHTPGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCE 654
Query: 584 KCKKLR-----------------NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 626
C + + N K + P +L +HLKRF+ K++ H+
Sbjct: 655 VCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIK 714
Query: 627 FPLEGLDLQPF-------LAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR-----NNL 674
FP E LDL PF +A+++ V Y L V+ H GT SGHY AY + ++L
Sbjct: 715 FP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVVEHSGTMRSGHYTAYAKARTANSHL 771
Query: 675 NNL-----------------WYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
+NL W+ D V V + V N++AY+LFY +
Sbjct: 772 SNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 820
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 134 bits (337), Expect = 3e-31
Identities = 178/829 (21%), Positives = 313/829 (37%), Gaps = 160/829 (19%)
Query: 23 GKQEKIPNKMSAFRNHCPHLDSVGEI--TKEDLIQKSLGTCQDCKVQG------------ 68
GK I + C H+ E K+ L+ CQDCK
Sbjct: 8 GKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEE 67
Query: 69 -PNLWACLENRCSYVGCGE-SQVDHSTIH---SQETKHYLTVNLTTLRVWCYACSKEVFL 123
P++W CL +C + GCG SQ H+ H + H L ++L VWCY C EV
Sbjct: 68 KPSVWLCL--KCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQY 125
Query: 124 DRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARG 183
+ +VR+ I + K N L+ + + E ++++ +
Sbjct: 126 CSSNQLGQVVDYVRKQASITTPKPAE-KDNGNIELENKKLEKESKNEQEREKKENMAKEN 184
Query: 184 ----------LTGLKNIGNTCYMNAALQALSNCPPLTQFF-----------LDCGGLART 222
+ GL N+GNTC+ NA +Q LS P L + ++ LA T
Sbjct: 185 PPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALT 244
Query: 223 D------KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFL 276
+ + P + +++ G V P LF + F+GY QQD+QE L
Sbjct: 245 EPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELL 304
Query: 277 RCLMD-----------------------LLHEELKEQVMEVEEDPQTITTEETMEEDKSQ 313
R L+D L EELK +V + E+ + + + +
Sbjct: 305 RYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELT 364
Query: 314 SDVDFQSCESCSNSDRA---------ENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQ 364
S + C + S + ++++G + ++ N + T+ +D ++ E D
Sbjct: 365 SMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSY 424
Query: 365 KEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQI----------HSRASEYITD 414
++ + + + + + + + + Q+ ++ ++ H SEY +
Sbjct: 425 IKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSEYEAE 484
Query: 415 VH-SNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRS 473
+ +++ S EGV + K N G A K +S + +K +
Sbjct: 485 MSLQGEVNIKSNHISQEGVMHKEYCVNQKDLN---GQA---KMIESVTDNQKSTEEVDMK 538
Query: 474 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533
I+ D +++S + +T + ++ + K L+++ HP I
Sbjct: 539 NINMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKN--LNLNAALHPDEI-NIEIL 595
Query: 534 GEAYAPQGWI----------AFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCE 583
+++ P + AF + F ++Q CL F ++L+ N CE
Sbjct: 596 NDSHTPGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCE 655
Query: 584 KCKKLR-----------------NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 626
C + + N K + P +L +HLKRF+ K++ H+
Sbjct: 656 VCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIK 715
Query: 627 FPLEGLDLQPF-------LAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR-----NNL 674
FP E LDL PF +A+++ V Y L V+ H GT SGHY AY + ++L
Sbjct: 716 FP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVVEHSGTMRSGHYTAYAKARTANSHL 772
Query: 675 NNL-----------------WYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
+NL W+ D V V + V N++AY+LFY +
Sbjct: 773 SNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 134 bits (337), Expect = 3e-31
Identities = 178/829 (21%), Positives = 313/829 (37%), Gaps = 160/829 (19%)
Query: 23 GKQEKIPNKMSAFRNHCPHLDSVGEI--TKEDLIQKSLGTCQDCKVQG------------ 68
GK I + C H+ E K+ L+ CQDCK
Sbjct: 8 GKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEE 67
Query: 69 -PNLWACLENRCSYVGCGE-SQVDHSTIH---SQETKHYLTVNLTTLRVWCYACSKEVFL 123
P++W CL +C + GCG SQ H+ H + H L ++L VWCY C EV
Sbjct: 68 KPSVWLCL--KCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQY 125
Query: 124 DRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARG 183
+ +VR+ I + K N L+ + + E ++++ +
Sbjct: 126 CSSNQLGQVVDYVRKQASITTPKPAE-KDNGNIELENKKLEKESKNEQEREKKENMAKEN 184
Query: 184 ----------LTGLKNIGNTCYMNAALQALSNCPPLTQFF-----------LDCGGLART 222
+ GL N+GNTC+ NA +Q LS P L + ++ LA T
Sbjct: 185 PPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALT 244
Query: 223 D------KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFL 276
+ + P + +++ G V P LF + F+GY QQD+QE L
Sbjct: 245 EPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELL 304
Query: 277 RCLMD-----------------------LLHEELKEQVMEVEEDPQTITTEETMEEDKSQ 313
R L+D L EELK +V + E+ + + + +
Sbjct: 305 RYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELT 364
Query: 314 SDVDFQSCESCSNSDRA---------ENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQ 364
S + C + S + ++++G + ++ N + T+ +D ++ E D
Sbjct: 365 SMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSY 424
Query: 365 KEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQI----------HSRASEYITD 414
++ + + + + + + + + Q+ ++ ++ H SEY +
Sbjct: 425 IKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSEYEAE 484
Query: 415 VH-SNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRS 473
+ +++ S EGV + K N G A K +S + +K +
Sbjct: 485 MSLQGEVNIKSNHISQEGVMHKEYCVNQKDLN---GQA---KMIESVTDNQKSTEEVDMK 538
Query: 474 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533
I+ D +++S + +T + ++ + K L+++ HP I
Sbjct: 539 NINMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKN--LNLNAALHPDEI-NIEIL 595
Query: 534 GEAYAPQGWI----------AFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCE 583
+++ P + AF + F ++Q CL F ++L+ N CE
Sbjct: 596 NDSHTPGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCE 655
Query: 584 KCKKLR-----------------NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVS 626
C + + N K + P +L +HLKRF+ K++ H+
Sbjct: 656 VCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIK 715
Query: 627 FPLEGLDLQPF-------LAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR-----NNL 674
FP E LDL PF +A+++ V Y L V+ H GT SGHY AY + ++L
Sbjct: 716 FP-EILDLAPFCTLKCKNVAEENTR--VLYSLYGVVEHSGTMRSGHYTAYAKARTANSHL 772
Query: 675 NNL-----------------WYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
+NL W+ D V V + V N++AY+LFY +
Sbjct: 773 SNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
Length = 814
Score = 134 bits (337), Expect = 3e-31
Identities = 181/830 (21%), Positives = 303/830 (36%), Gaps = 162/830 (19%)
Query: 14 KVLPHFESLGKQEKIPNKMSAFRN--------HCPHLDSVGEITKEDLIQKSLGTCQDCK 65
K LP K+ +P+ + + H H SV + K + + C +C
Sbjct: 8 KALPEKAKRSKRPTVPHDEDSSDDIAVGLTCQHVSHAISVNHV-KRAIAENLWSVCSECL 66
Query: 66 ----------VQGPNLWACLENRCSYVGCGE-SQVDHSTIHSQETK---HYLTVNLTTLR 111
V ++W CL +C + GCG+ S+ HS H + ++ H + +NL+T
Sbjct: 67 KERRFYDGQLVLTSDIWLCL--KCGFQGCGKNSESQHSLKHFKSSRTEPHCIIINLSTWI 124
Query: 112 VWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDI 171
+WCY C D KL T + + Q + DF + +T + L
Sbjct: 125 IWCYEC------DEKLSTHCNKKVLAQ--------IVDFLQKHASKTQTSAFSRIMKLCE 170
Query: 172 EADEEDELRARG------LTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK- 224
E E DE++ G + G+ N+GNTC+ NA +Q L+ LT + + K
Sbjct: 171 EKCETDEIQKGGKCRNLSVRGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKI 230
Query: 225 ----------------KPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYS 268
+P S L L ++ G + P LF + P F+ +
Sbjct: 231 FPSSDSQLDPLVVELSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQ 290
Query: 269 QQDAQEFLRCLMDLLHEE----LKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESC 324
QQD+QE L L+D + E ++ +++ +P T T ++ + +
Sbjct: 291 QQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFI 350
Query: 325 SNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKD 384
E + C N T D + + + K + ++NK S E D D
Sbjct: 351 DRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSKPLLWGRMNKYRSLRETDHD 410
Query: 385 RDSISETVDLNNQETVKVQIHSRASEYITDVHS----NDLSTPQILPSNEGVN------- 433
R S + T++ N + + HS + + +H LS+ + + + N
Sbjct: 411 RYSGNVTIE-NIHQPRAAKKHSSSKDKSQLIHDRKCIRKLSSGETVTYQKNENLEMNGDS 469
Query: 434 ----------PRLSASPPKSGNLWPGLAPPHKKAQ---SASPKRKKQHKKYRS------- 473
RL+ SP + + A S S KQ +RS
Sbjct: 470 LMFASLMNSESRLNESPTDDSEKEASHSESNVDADSEPSESESASKQTGLFRSSSGSGVQ 529
Query: 474 ---VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVK- 529
+ + G ++ + + + D+ + LS + G +D + + P +I
Sbjct: 530 PDGPLYPLSAGKLLYTKETDSGDKEMAEAISELRLSSTVTGDQDFDR---ENQPLNISNN 586
Query: 530 ----AGSCGEAYAPQ-GWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEK 584
G +Y+PQ + Y+ + ++Q CL F + + L G+N CE
Sbjct: 587 LCFLEGKHLRSYSPQNAFQTLSQSYITT---SKECSIQSCLYQFTSMELLMGNNKLLCEN 643
Query: 585 CKKLR-------------------NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHV 625
C K + N K + P +L +HLKRF + K++ HV
Sbjct: 644 CTKNKQKYQEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHV 703
Query: 626 SFPLEGLDLQPFLA----KDSPAQIVTYDLLSVICHHGTASSGHYIAYCR---------- 671
FPL LDL PF + S V Y L ++ H G+ GHY AY +
Sbjct: 704 DFPLM-LDLAPFCSATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKLSE 762
Query: 672 ---------------NNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
N W D + V ES +A+AY+LFY +
Sbjct: 763 HNTKKKNVPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYER 812
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 124 bits (312), Expect = 3e-28
Identities = 80/247 (32%), Positives = 112/247 (45%), Gaps = 37/247 (14%)
Query: 474 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533
+I IF G + S V C C VS T++ F D+SL +PG SS P + GS
Sbjct: 296 IIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPG---------SSTPFWPLSPGSE 346
Query: 534 GEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVK 593
G + ++ TL DCL F + L C C + K
Sbjct: 347 GNVVNGESHVS------------GTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTK 394
Query: 594 FCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAK------------- 640
++ P + C HLKRF H KI+T+VSFPLE LD+ PF+A
Sbjct: 395 QLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLE-LDMTPFMASSKESRMNGQYQQP 453
Query: 641 -DSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEA 699
DS Y L +V+ H GT SGHY ++ R + + W++ DD +T+ S V ++E
Sbjct: 454 TDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQH-KDQWFKCDDAIITKASIKDVLDSEG 512
Query: 700 YVLFYRK 706
Y+LFY K
Sbjct: 513 YLLFYHK 519
Score = 69.7 bits (169), Expect = 1e-11
Identities = 57/235 (24%), Positives = 96/235 (40%), Gaps = 25/235 (10%)
Query: 61 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKE 120
C C V L +CL C + GC + H H++ +H L ++L ++C+ C
Sbjct: 63 CHVCGVHLNRLHSCLY--CVFFGCFTKKHIHE--HAKAKRHNLAIDLMYGGIYCFLCQDY 118
Query: 121 VFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELR 180
++ + + + Q + +Q +T T ++E + + R
Sbjct: 119 IY-------DKDMEIIAKEEQRKAWKMQGVGEKFSTWEPTKR-------ELELLKHNPKR 164
Query: 181 AR-------GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYL 233
+ GL GL N+GNTC+MN +QAL++ P L FFL + +
Sbjct: 165 RKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEM 224
Query: 234 KLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 288
+ + ++ +P L + T GY QQDA EFL +D+LH K
Sbjct: 225 SSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCK 279
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 122 bits (307), Expect = 1e-27
Identities = 81/262 (30%), Positives = 121/262 (46%), Gaps = 40/262 (15%)
Query: 474 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533
+I IF G + S V C C VS T++ D+SL +PG +S P S + S
Sbjct: 198 IIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS------CTSFWPMSPGRESSV 251
Query: 534 -GEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGV 592
GE++ P + TL DCL F + L C C+ +
Sbjct: 252 NGESHIPG-----------------ITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQEST 294
Query: 593 KFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA------QI 646
K + P + C H KRF H KI+T++SFPLE LD+ PF+A + Q+
Sbjct: 295 KQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLE-LDMTPFMASSKESRMNGQLQL 353
Query: 647 VT--------YDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAE 698
T Y L +V+ H GT SGHY ++ R++ + W++ DD +T+ S V ++E
Sbjct: 354 PTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHH-KDQWFKCDDAVITKASIKDVLDSE 412
Query: 699 AYVLFYRKSSEEAQKERRRISN 720
Y+LFY K E + E+ + N
Sbjct: 413 GYLLFYHKQVLEHESEKVKEMN 434
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/149 (33%), Positives = 67/149 (44%), Gaps = 6/149 (4%)
Query: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICK--SYLKLMTELW 240
GL GL N+GNTC+MN +QAL++ P L FFL P +C L EL
Sbjct: 76 GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEM-PSPELCLVCEMSSLFREL- 133
Query: 241 HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK-EQVMEVEEDPQ 299
+ P VP L + GY QQDA EFL +D+LH K + V + +P
Sbjct: 134 YSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPN 193
Query: 300 TIT-TEETMEEDKSQSDVDFQSCESCSNS 327
+ + QSDV Q+C S +
Sbjct: 194 HCNCIIDQIFTGGLQSDVTCQACHGVSTT 222
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 118 bits (295), Expect = 3e-26
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)
Query: 559 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 618
V L+DC+ F + L + + C CKK + K + + P+IL +HLKRF + +
Sbjct: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
Query: 619 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 678
K+ T V FP+ GL++ F+ S A+ YDL++V H+G GHY AY +N LN W
Sbjct: 836 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 894
Query: 679 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 713
Y FDD +V+ SE + AYVLFY++ +E K
Sbjct: 895 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 929
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)
Query: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236
GL GL N+GNTC+MN+ALQ LSN PLT +FL A ++ K I ++Y +L+
Sbjct: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
Query: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 292
++W R V P + P F GY QQD+QE L L+D LHE+L K+ +
Sbjct: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
Query: 293 EVEE---DPQTITTEETMEEDKSQSD 315
E+++ P + +E E + ++D
Sbjct: 419 ELKDANGRPDAVVAKEAWENHRLRND 444
Score = 39.7 bits (91), Expect = 0.012
Identities = 20/42 (47%), Positives = 27/42 (64%)
Query: 473 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
SVI D F G S++ C C +VSVT + F L+LP+P K+D
Sbjct: 445 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 486
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 118 bits (295), Expect = 3e-26
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 1/155 (0%)
Query: 559 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 618
V L+DC+ F + L + + C CKK + K + + P+IL +HLKRF + +
Sbjct: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
Query: 619 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 678
K+ T V FP+ GL++ F+ S A+ YDL++V H+G GHY AY +N LN W
Sbjct: 789 DKLDTVVEFPIRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW 847
Query: 679 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQK 713
Y FDD +V+ SE + AYVLFY++ +E K
Sbjct: 848 YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYK 882
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/146 (36%), Positives = 79/146 (54%), Gaps = 14/146 (9%)
Query: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK------KPAICKSYLKLM 236
GL GL N+GNTC+MN+ALQ LSN PLT +FL A ++ K I ++Y +L+
Sbjct: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
Query: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQVM 292
++W R V P + P F GY QQD+QE L L+D LHE+L K+ +
Sbjct: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
Query: 293 EVEE---DPQTITTEETMEEDKSQSD 315
E+++ P + +E E + ++D
Sbjct: 372 ELKDANGRPDAVVAKEAWENHRLRND 397
Score = 39.7 bits (91), Expect = 0.012
Identities = 20/42 (47%), Positives = 27/42 (64%)
Query: 473 SVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
SVI D F G S++ C C +VSVT + F L+LP+P K+D
Sbjct: 398 SVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKD 439
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 118 bits (295), Expect = 3e-26
Identities = 67/198 (33%), Positives = 97/198 (48%), Gaps = 23/198 (11%)
Query: 560 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 619
TL C + + L D+ + C CK+L+ G + P++L IHLKRFR E
Sbjct: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRM 656
Query: 620 KISTHVSFPLEGLDLQPFLAKDSPA---------------------QIVTYDLLSVICHH 658
K+ V FPL GLD+ P + K S + + YDL +V HH
Sbjct: 657 KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHH 716
Query: 659 GTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRI 718
GT GHY AYC+N+++ LWY FDD V ++SE V AY+LFY++ + A
Sbjct: 717 GTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRT--AIPSWSAN 774
Query: 719 SNLLNIMEPSLLQFYISR 736
S++ SL + ++SR
Sbjct: 775 SSVAGSTSSSLCEHWVSR 792
Score = 56.6 bits (135), Expect = 9e-08
Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 30/147 (20%)
Query: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LDCGGLARTDKKP--------------A 227
G+ GL+N GNTC+MNA LQ LSN ++ L R + P
Sbjct: 126 GVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGE 185
Query: 228 ICKSYLKLMTELW-------HKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 280
+ + L+ LW H ++V Q +RG SQ DAQEFL L+
Sbjct: 186 VTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQ--------YRGNSQHDAQEFLLWLL 237
Query: 281 DLLHEELKEQVMEVEEDPQTITTEETM 307
D +HE+L V + + P +E M
Sbjct: 238 DRVHEDLNHSVKQSGQPPLKPPSETDM 264
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 118 bits (295), Expect = 3e-26
Identities = 96/341 (28%), Positives = 140/341 (41%), Gaps = 55/341 (16%)
Query: 369 CNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPS 428
C +N F K S S + QE +K+ + E ++ P IL +
Sbjct: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLE----INRRGRRAPPILAN 330
Query: 429 NEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQ 488
+P P + G L P A+ K+ ++ S I D+F G + S ++
Sbjct: 331 GPVPSP-----PRRGGALLE--EPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLK 383
Query: 489 CLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFME 548
C C S T E F DLSLPIP
Sbjct: 384 CQACGYRSTTFEVFCDLSLPIP-------------------------------------- 405
Query: 549 YVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHL 608
K F G V+L+DC F +EL+ +N C++C++ K VQ FP IL +HL
Sbjct: 406 --KKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHL 463
Query: 609 KRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIA 668
RF K S V FPL+ L L F + + + + Y L ++ H G+ GHY A
Sbjct: 464 NRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV--YQLYALCNHSGSVHYGHYTA 521
Query: 669 YCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSE 709
CR W+ ++D V+ VSE+ V ++E YVLFY+ E
Sbjct: 522 LCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQLMQE 560
Score = 78.6 bits (192), Expect = 2e-14
Identities = 45/118 (38%), Positives = 65/118 (55%), Gaps = 9/118 (7%)
Query: 179 LRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSY 232
L G GL+N+GNTC++NA LQ LS+ PL F L + G R + + +++
Sbjct: 206 LLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAF 262
Query: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQ 290
++ LWH +V PT + P+F GYSQQDAQEFL+ LM+ LH E+ +
Sbjct: 263 ADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR 320
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 118 bits (295), Expect = 3e-26
Identities = 96/341 (28%), Positives = 140/341 (41%), Gaps = 55/341 (16%)
Query: 369 CNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPS 428
C +N F K S S + QE +K+ + E ++ P IL +
Sbjct: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLE----INRRGRRAPPILAN 330
Query: 429 NEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQ 488
+P P + G L P A+ K+ ++ S I D+F G + S ++
Sbjct: 331 GPVPSP-----PRRGGALLE--EPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLK 383
Query: 489 CLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFME 548
C C S T E F DLSLPIP
Sbjct: 384 CQACGYRSTTFEVFCDLSLPIP-------------------------------------- 405
Query: 549 YVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHL 608
K F G V+L+DC F +EL+ +N C++C++ K VQ FP IL +HL
Sbjct: 406 --KKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHL 463
Query: 609 KRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIA 668
RF K S V FPL+ L L F + + + + Y L ++ H G+ GHY A
Sbjct: 464 NRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV--YQLYALCNHSGSVHYGHYTA 521
Query: 669 YCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSE 709
CR W+ ++D V+ VSE+ V ++E YVLFY+ E
Sbjct: 522 LCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQLMQE 560
Score = 78.6 bits (192), Expect = 2e-14
Identities = 45/118 (38%), Positives = 65/118 (55%), Gaps = 9/118 (7%)
Query: 179 LRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSY 232
L G GL+N+GNTC++NA LQ LS+ PL F L + G R + + +++
Sbjct: 206 LLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAF 262
Query: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQ 290
++ LWH +V PT + P+F GYSQQDAQEFL+ LM+ LH E+ +
Sbjct: 263 ADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR 320
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 112 bits (279), Expect = 2e-24
Identities = 74/250 (29%), Positives = 108/250 (43%), Gaps = 36/250 (14%)
Query: 474 VISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533
+I IF G + S V C C VS T++ D+SL +PG + S V
Sbjct: 483 IIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSR--- 539
Query: 534 GEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVK 593
+ + P + +L DCL F + L C C+ + K
Sbjct: 540 -DDHIPG-----------------IPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTK 581
Query: 594 FCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIV------ 647
++ P + C HLKRF H KI+T +SFPLE LD+ PFLA +++
Sbjct: 582 QLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE-LDMTPFLASTKESRMKEGQPPT 640
Query: 648 -------TYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAY 700
Y L +VI HHGT SGHY ++ R + W+ DD +T+ + + +E Y
Sbjct: 641 DCVPNENKYSLFAVINHHGTLESGHYTSFIRQQ-KDQWFSCDDAIITKATIEDLLYSEGY 699
Query: 701 VLFYRKSSEE 710
+LFY K E
Sbjct: 700 LLFYHKQGLE 709
Score = 79.7 bits (195), Expect = 1e-14
Identities = 78/293 (26%), Positives = 119/293 (40%), Gaps = 47/293 (16%)
Query: 61 CQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYAC--- 117
C C L +CL C + GC + H H++ +H+L V+L ++C+ C
Sbjct: 236 CHVCSTHMNRLHSCLS--CVFFGCFTEKHIHK--HAETKQHHLAVDLYHGVIYCFMCKDY 291
Query: 118 ------------SKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAV 165
+KE L T + H Q + +D + T + P +
Sbjct: 292 VYDKDIEQIAKETKEKILRLLTSTSTDVSH----QQFMTSGFEDKQSTCETKEQEPKLVK 347
Query: 166 FDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDK- 224
+ + + GL GL N+GNTC+MN +QAL++ P L FFL +DK
Sbjct: 348 ----PKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFL-------SDKH 396
Query: 225 -----KPAICKSYLKLMTELWHKSRPGS---VVPTTLFQGIKTVNPTFRGYSQQDAQEFL 276
P++C + M+ L+H GS +P L I GY QQDA EFL
Sbjct: 397 KCIMTSPSLC--LVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFL 454
Query: 277 RCLMDLLHEELKEQV--MEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNS 327
++D+LH K+ E + + QSDV Q+C S S +
Sbjct: 455 IAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTT 507
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 111 bits (277), Expect = 3e-24
Identities = 61/169 (36%), Positives = 86/169 (50%), Gaps = 22/169 (13%)
Query: 560 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 619
TL +C + ++L D+ + C C+ L+ G+ + P+IL IHLKRF
Sbjct: 541 TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRN 600
Query: 620 KISTHVSFPLEGLDLQPFLAKDS---------------PAQIVT-------YDLLSVICH 657
K+ST V FPL GL++ P +A+ S P + T YDL +V H
Sbjct: 601 KLSTLVKFPLSGLNMAPHVAQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNH 660
Query: 658 HGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
HG GHY AYCRN+L+ WY +DD +V + E V AY+LFY+K
Sbjct: 661 HGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/112 (34%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 177 DELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLM 236
D R G GLKN GNTC+MNA +Q LSN L + FL G + + + L+
Sbjct: 93 DGARPPGAQGLKNHGNTCFMNAVVQCLSNTDLLAE-FLALGRYRAAPGRAEVTEQLAALV 151
Query: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 288
LW + + + F+G SQ DA EFL L+D +HE+L+
Sbjct: 152 RALWTREYTPQ-LSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 110 bits (275), Expect = 5e-24
Identities = 53/150 (35%), Positives = 84/150 (56%), Gaps = 1/150 (0%)
Query: 557 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 616
P V L+DC+ F +++L ++ + C CK+ + K + + P +L +HLKRF +
Sbjct: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
Query: 617 FSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNN 676
K+ T V FP+ LD+ FL + A Y+L++V H+G GHY A+ +N +
Sbjct: 815 MRDKLDTLVDFPINDLDMSEFLINPN-AGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDG 873
Query: 677 LWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
WY FDD SV+ SE + + AYVLFY++
Sbjct: 874 KWYYFDDSSVSTASEDQIVSKAAYVLFYQR 903
Score = 90.1 bits (222), Expect = 7e-18
Identities = 52/146 (35%), Positives = 75/146 (51%), Gaps = 14/146 (9%)
Query: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------KKPAICKSYLKLM 236
GL GL N+GNTC+MN+A+Q LSN PPLT++FL+ + + I KSY +L+
Sbjct: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELI 317
Query: 237 TELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE------- 289
++W + V P + P F GY QQD QE L L+D LHE+L
Sbjct: 318 KQMW-SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYI 376
Query: 290 QVMEVEEDPQTITTEETMEEDKSQSD 315
Q+ + + P + EE E ++D
Sbjct: 377 QLKDADGRPDKVVAEEAWENHLKRND 402
Score = 40.8 bits (94), Expect = 0.005
Identities = 19/46 (41%), Positives = 30/46 (65%)
Query: 469 KKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKED 514
K+ S+I DIF G S++ C C ++SVT + F L+LP+P K++
Sbjct: 399 KRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKE 444
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 107 bits (266), Expect = 6e-23
Identities = 54/151 (35%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Query: 559 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS 618
V LQ+C+ F + L+ +N + C CK+ + K + PEIL IHLKRF +
Sbjct: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
Query: 619 TKISTHVSFPLEGLDLQPFLAK---DSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLN 675
K+ T V FP+ LD F+ + +S ++ YDL++V H+G GHY + N +
Sbjct: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
Query: 676 NLWYEFDDQSVTEVSESTVQNAEAYVLFYRK 706
W+ FDD SV+ V+E+ +++ AYVLFY++
Sbjct: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 929
Score = 80.1 bits (196), Expect = 8e-15
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 14/159 (8%)
Query: 170 DIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTD------ 223
++ ++ED G+ GL N+GNTC+MN+ALQ LSN P LT++FL+ L +
Sbjct: 294 NMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLG 353
Query: 224 KKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLL 283
K I ++Y L+ + W S+VP + F GY Q D+QE L L+D L
Sbjct: 354 MKGEIAEAYADLVKQAW-SGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGL 412
Query: 284 HEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 315
HE+L ++ + P +E + K ++D
Sbjct: 413 HEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRND 451
Score = 39.3 bits (90), Expect = 0.015
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 452 PPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIP 510
P + AQ A K+++ SVI D F G S++ C C VSVT + F LS+P+P
Sbjct: 434 PDQEVAQEAWQNHKRRND---SVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLP 489
>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
Length = 712
Score = 102 bits (255), Expect = 1e-21
Identities = 74/264 (28%), Positives = 118/264 (44%), Gaps = 53/264 (20%)
Query: 464 RKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSH 523
++K K+ +V+++IF G ++S V CL CD S T+E F DLSL P + + +S
Sbjct: 454 QRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKDIASQ 513
Query: 524 PTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCE 583
P + + LA F + L+G +Y C+
Sbjct: 514 PCLVT----------------------------------EMLAKFTETEALEG-KIYVCD 538
Query: 584 KCKKLRN-----------GVKFCKVQNFPEILCIHLKRFRHELMFST-KISTHVSFPLEG 631
+C R K + + P++L +HLKRFR + KI HV F E
Sbjct: 539 QCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFRWSGRNNREKIGVHVGFE-EI 597
Query: 632 LDLQPFLAKDSPAQI----VTYDLLSVICHHGTA-SSGHYIAYCRNNLNNLWYEFDDQSV 686
L+++P+ +++ + YDL +V+ HHG SGHY AYC N+ W +D +
Sbjct: 598 LNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGFGSGHYTAYCYNSEGGFWVHCNDSKL 657
Query: 687 TEVSESTVQNAEAYVLFYRKSSEE 710
+ + V A+AY+LFY + E
Sbjct: 658 SMCTMDEVCKAQAYILFYTQRVTE 681
Score = 53.1 bits (126), Expect = 1e-06
Identities = 51/170 (30%), Positives = 67/170 (39%), Gaps = 64/170 (37%)
Query: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFL----------DCGGLARTDKKPAICKSY 232
G+TGL+N+GNTCYMN+ LQ LS+ Q FL R+ K P + +
Sbjct: 271 GVTGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTV 330
Query: 233 LKLMTELWHK------SRPGSV--------------------VPT-----------TLFQ 255
+ M E K SR S+ PT TLFQ
Sbjct: 331 VYQMNECQEKDTGFVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQ 390
Query: 256 -----------------GIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 288
+ + P FRGY+QQDAQEFL L+D + EL+
Sbjct: 391 VMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRELE 440
Score = 52.0 bits (123), Expect = 2e-06
Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 39 CPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQE 98
C H+ + + C DC ++WACL CS+V CG +H+ H QE
Sbjct: 7 CKHVGQLQLAQDHSSLNPQKWHCVDCNTT-ESIWACLS--CSHVACGRYIEEHALKHFQE 63
Query: 99 TKHYLTVNLTTLRVWCYACSKEVFLDRKLG 128
+ H + + + + V+CY C V D G
Sbjct: 64 SSHPVALEVNEMYVFCYLCDDYVLNDNTTG 93
>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
Length = 1035
Score = 98.2 bits (243), Expect = 3e-20
Identities = 76/323 (23%), Positives = 139/323 (43%), Gaps = 78/323 (24%)
Query: 561 LQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKR--FRHELMFS 618
L DC++ F ++L+GDN Y CE C+ +N + ++ + P L + L R F +
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHK 308
Query: 619 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHG-TASSGHYIAYCRNNLNNL 677
K++T++ F E LD++P++ + + Y+L +V+ H G +A SGHYIA+ ++ +
Sbjct: 309 KKLNTYIGFS-EILDMEPYVEHKGGSYV--YELSAVLIHRGVSAYSGHYIAHVKDPQSGE 365
Query: 678 WYEFDDQSVTEVSESTVQ--------------------------NAEAYVLFYRKSSEEA 711
WY+F+D+ + ++ +Q + AY+L YR ++E
Sbjct: 366 WYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRKPKCGKGTHCSRNAYMLVYRLQTQEK 425
Query: 712 QKERRRISNLL-NIMEPSLLQF-------------------------------------- 732
++ L +++ +F
Sbjct: 426 PNTTVQVPAFLQELVDRDNSKFEEWCIEMAEMRKQSVDKGKAKHEEVKELYQRLPAGAEP 485
Query: 733 --YISRQWLNKFKTFAEP-GPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSR 789
++S +WL K+ + P PI N+ LC H + P K ++ + + D YSR
Sbjct: 486 YEFVSLEWLQKWLDESTPTKPIDNHACLCSHDKLHPDKI----SIMKRISEYAADIFYSR 541
Query: 790 YGGGPAVNHLYICHTCQIEAEKI 812
YGGGP + +C C +E +I
Sbjct: 542 YGGGPRLTVKALCKECVVERCRI 564
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/122 (27%), Positives = 50/122 (40%), Gaps = 16/122 (13%)
Query: 180 RARGLTGLKNIGNTCYMNAALQ----------ALSNCPPL-TQFFLDCGGLARTDKKPAI 228
+ GL N+G TCY+N LQ AL CP + + L G D +P
Sbjct: 84 KKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEKDYEPQT 143
Query: 229 CKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELK 288
+L+ + L S + P+ + + QQDAQEF + M LL + L
Sbjct: 144 ICEHLQYLFALLQNSNRRYIDPSGFVKALGLDTG-----QQQDAQEFSKLFMSLLEDTLS 198
Query: 289 EQ 290
+Q
Sbjct: 199 KQ 200
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/165 (35%), Positives = 82/165 (49%), Gaps = 8/165 (4%)
Query: 560 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFR-HELMFS 618
TL CL F + L + + C +CK+ R K + P +L + LKRF ++
Sbjct: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
Query: 619 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR--NNLNN 676
KI+ V FP+ LDL F Q+ +YDL +VI H+G GHY A R N+ ++
Sbjct: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
Query: 677 L-----WYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERR 716
W FDD +VT V ES V AYVLFYR+ + ++ R
Sbjct: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 167 DDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKK- 225
D ++ E +EE ++ G TGL N+GNTC+MN+ +Q+LSN L FF D A +
Sbjct: 479 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 538
Query: 226 -----PAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 280
+ + L+ LW K + P+ L + + F GY+Q DAQEF+ L+
Sbjct: 539 PLGTGGRLAIGFAVLLRALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLL 597
Query: 281 DLLHEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 315
D LHE+L + ++ + P + EE + K ++D
Sbjct: 598 DGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRND 639
Score = 36.2 bits (82), Expect = 0.13
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 466 KQHK-KYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKE 513
++HK + S I D+F G S + C C +VS+T + F L +P+P K+
Sbjct: 632 QRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,869,114
Number of Sequences: 37866
Number of extensions: 1602715
Number of successful extensions: 7295
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 6383
Number of HSP's gapped (non-prelim): 744
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.