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Search of human proteins with 42476028
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42476028 ATPase family, AAA domain containing 3A [Homo
sapiens]
(634 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42476028 ATPase family, AAA domain containing 3A [Homo sapiens] 1251 0.0
gi|75677353 AAA-ATPase TOB3 [Homo sapiens] 1046 0.0
gi|194018490 ATPase family, AAA domain containing 3C [Homo sapiens] 634 0.0
gi|169218287 PREDICTED: similar to belphegor [Homo sapiens] 302 5e-82
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens] 67 4e-11
gi|40806170 spastin isoform 2 [Homo sapiens] 67 5e-11
gi|11875211 spastin isoform 1 [Homo sapiens] 67 5e-11
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 65 2e-10
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens] 64 6e-10
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 63 7e-10
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens] 63 9e-10
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens] 62 1e-09
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 62 1e-09
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 62 1e-09
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 62 1e-09
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 62 1e-09
gi|31742536 fidgetin-like 1 [Homo sapiens] 62 2e-09
gi|112789543 fidgetin-like 1 [Homo sapiens] 62 2e-09
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens] 62 2e-09
gi|148746195 trichohyalin [Homo sapiens] 61 4e-09
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens] 61 4e-09
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens] 61 4e-09
gi|6005942 valosin-containing protein [Homo sapiens] 60 5e-09
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens] 59 1e-08
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens] 59 1e-08
gi|5901990 katanin p60 subunit A 1 [Homo sapiens] 59 1e-08
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens] 58 2e-08
gi|157671927 spermatogenesis associated 5 [Homo sapiens] 58 3e-08
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens] 57 7e-08
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens] 56 9e-08
>gi|42476028 ATPase family, AAA domain containing 3A [Homo sapiens]
Length = 634
Score = 1251 bits (3237), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 1 MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK
Sbjct: 1 MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
Query: 61 AARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQT 120
AARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQT
Sbjct: 61 AARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQT 120
Query: 121 QERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY 180
QERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY
Sbjct: 121 QERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY 180
Query: 181 QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAE 240
QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAE
Sbjct: 181 QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAE 240
Query: 241 ARARAKAERENADITREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVA 300
ARARAKAERENADITREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVA
Sbjct: 241 ARARAKAERENADITREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVA 300
Query: 301 GLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ 360
GLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ
Sbjct: 301 GLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ 360
Query: 361 DALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMD 420
DALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMD
Sbjct: 361 DALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMD 420
Query: 421 YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRAT 480
YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRAT
Sbjct: 421 YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRAT 480
Query: 481 LNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKY 540
LNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKY
Sbjct: 481 LNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKY 540
Query: 541 VLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEA 600
VLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEA
Sbjct: 541 VLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEA 600
Query: 601 MMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS 634
MMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS
Sbjct: 601 MMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS 634
>gi|75677353 AAA-ATPase TOB3 [Homo sapiens]
Length = 648
Score = 1046 bits (2706), Expect = 0.0
Identities = 547/630 (86%), Positives = 562/630 (89%), Gaps = 48/630 (7%)
Query: 1 MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
MSWLFG+NKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK
Sbjct: 1 MSWLFGVNKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
Query: 61 AARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQT 120
AARELEHSRYAK+ALNLAQMQEQTLQLEQQSKLK
Sbjct: 61 AARELEHSRYAKEALNLAQMQEQTLQLEQQSKLK-------------------------- 94
Query: 121 QERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY 180
EYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY
Sbjct: 95 ----------------------EYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY 132
Query: 181 QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAE 240
QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVE E
Sbjct: 133 QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETE 192
Query: 241 ARARAKAERENADITREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVA 300
ARARAKAERENADI REQIRLKA+EHRQTVLESIRTAGTLFGEGFRAFVTD DKVTATVA
Sbjct: 193 ARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVA 252
Query: 301 GLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ 360
GLTLLAVGVYSAKNAT V GRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ
Sbjct: 253 GLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ 312
Query: 361 DALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMD 420
D LEGVVLSPSLEARVRDIAIATRNTKKNR LYR+IL+YGPPGTGKTLFAKKLALHSGMD
Sbjct: 313 DVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMD 372
Query: 421 YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRAT 480
YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLF+DEADAFLRKRATE+IS+DLRAT
Sbjct: 373 YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRAT 432
Query: 481 LNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKY 540
LNAFLY GQHSNKFMLVLASN PEQFD AIN RI+ MVHFDLP QEERERLVR++FD
Sbjct: 433 LNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNC 492
Query: 541 VLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEA 600
VLKPATEGK+RLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYAS+DGVLTEA
Sbjct: 493 VLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEA 552
Query: 601 MMDTRVQDAVQQHQQKMCWLKAEGPGRGDE 630
MMD VQDAVQQ++QKM WLKAEGPGRG E
Sbjct: 553 MMDACVQDAVQQYRQKMRWLKAEGPGRGVE 582
>gi|194018490 ATPase family, AAA domain containing 3C [Homo sapiens]
Length = 411
Score = 634 bits (1635), Expect = 0.0
Identities = 347/458 (75%), Positives = 364/458 (79%), Gaps = 56/458 (12%)
Query: 178 AQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRV 237
AQ Q++ + E Q K +QL+NE+ LRKQEESVQK
Sbjct: 9 AQMQEQTLQ--LEQQSKLKQLVNED-LRKQEESVQK------------------------ 41
Query: 238 EAEARARAKAERENADITREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTA 297
H QT LESIR AGTLFGEGFRAFVTD DKVTA
Sbjct: 42 ----------------------------HHQTFLESIRAAGTLFGEGFRAFVTDRDKVTA 73
Query: 298 TVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPI-QVSRRLL 356
TVAGLTLLAVGVYSAKNAT V GR+IEARLGKPSLVRETSRITVLEALRHPI QVSRRLL
Sbjct: 74 TVAGLTLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEALRHPIQQVSRRLL 133
Query: 357 SRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALH 416
SRPQD LEGVVLSPSLEARVRDIAI TRN KKNR LYR+IL+YGPPGTGKTLFAKKLALH
Sbjct: 134 SRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPGTGKTLFAKKLALH 193
Query: 417 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED 476
SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED
Sbjct: 194 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED 253
Query: 477 LRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMY 536
LRATLNAFLYRTGQHSNKFML+LAS PEQFDWAIN I+ MVHFDLPGQEER RLVRMY
Sbjct: 254 LRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINACIDVMVHFDLPGQEERARLVRMY 313
Query: 537 FDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGV 596
++YVLKPATEGK+RLKLAQFDYGRKC E+ARLTEGMS R+IAQLAVSWQATAYAS+DGV
Sbjct: 314 LNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLAVSWQATAYASKDGV 373
Query: 597 LTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS 634
LTEAMMD VQD VQQHQQ M WLK E PG DE S
Sbjct: 374 LTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPSS 411
Score = 47.0 bits (110), Expect = 5e-05
Identities = 23/24 (95%), Positives = 24/24 (100%)
Query: 71 AKDALNLAQMQEQTLQLEQQSKLK 94
+KDALNLAQMQEQTLQLEQQSKLK
Sbjct: 2 SKDALNLAQMQEQTLQLEQQSKLK 25
>gi|169218287 PREDICTED: similar to belphegor [Homo sapiens]
Length = 284
Score = 302 bits (774), Expect = 5e-82
Identities = 154/177 (87%), Positives = 164/177 (92%)
Query: 454 LLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAIND 513
LLLF+DEADAFLRKRATE+IS+DLRATLNAFLY GQHSNKFMLVLASN PEQFD AIN
Sbjct: 42 LLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINS 101
Query: 514 RINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGM 573
RI+ MVHFDLP QEERERLVR++FD VLKPATEGK+RLKLAQFDYGRKCSEVARLTEGM
Sbjct: 102 RIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGM 161
Query: 574 SGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDE 630
SGREIAQLAVSWQATAYAS+DGVLTEAMMD VQDAVQQ++QKM WLKAEGPGRG E
Sbjct: 162 SGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVE 218
>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
Length = 795
Score = 67.4 bits (163), Expect = 4e-11
Identities = 63/212 (29%), Positives = 102/212 (48%), Gaps = 28/212 (13%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 452
+ L+ GPPG GKTL AK +A + + + M G + V +G G + LF A +R
Sbjct: 343 KGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEAR-ARA 401
Query: 453 GLLLFVDEADAFLRKRATEK---ISEDLRATLNAFLYR-TGQHSNKFMLVLAS-NQPEQF 507
++++DE DA +KR+T + + TLN L G + ++VLAS N+ +
Sbjct: 402 PCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADIL 461
Query: 508 DWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFD--YGRKC 563
D A+ R++ V DLP +ER + + + LKL Q Y ++
Sbjct: 462 DGALMRPGRLDRHVFIDLPTLQERREIFEQHL------------KSLKLTQSSTFYSQR- 508
Query: 564 SEVARLTEGMSGREIAQLAVSWQATAYASEDG 595
+A LT G SG +IA + +A +A+ +G
Sbjct: 509 --LAELTPGFSGADIANICN--EAALHAAREG 536
>gi|40806170 spastin isoform 2 [Homo sapiens]
Length = 584
Score = 67.0 bits (162), Expect = 5e-11
Identities = 57/227 (25%), Positives = 107/227 (47%), Gaps = 28/227 (12%)
Query: 360 QDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGM 419
+ AL+ +V+ PSL + R+ R +L++GPPG GKT+ AK +A S
Sbjct: 319 KQALQEIVILPSLRPEL---------FTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNA 369
Query: 420 DYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLR 478
+ ++ + + EG + LF A + ++F+DE D+ L +R + R
Sbjct: 370 TFFNISAASLTSKYVGEGEKLVRALFAVARELQPS-IIFIDEVDSLLCERREGEHDASRR 428
Query: 479 ATLNAFLYRTGQHS---NKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRM 535
+ G S ++ +++ A+N+P++ D A+ R + V+ LP +E R L++
Sbjct: 429 LKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKN 488
Query: 536 YFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLA 582
K P T+ ++ +++AR+T+G SG ++ LA
Sbjct: 489 LLCKQG-SPLTQ-------------KELAQLARMTDGYSGSDLTALA 521
>gi|11875211 spastin isoform 1 [Homo sapiens]
Length = 616
Score = 67.0 bits (162), Expect = 5e-11
Identities = 57/227 (25%), Positives = 107/227 (47%), Gaps = 28/227 (12%)
Query: 360 QDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGM 419
+ AL+ +V+ PSL + R+ R +L++GPPG GKT+ AK +A S
Sbjct: 351 KQALQEIVILPSLRPEL---------FTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNA 401
Query: 420 DYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLR 478
+ ++ + + EG + LF A + ++F+DE D+ L +R + R
Sbjct: 402 TFFNISAASLTSKYVGEGEKLVRALFAVARELQPS-IIFIDEVDSLLCERREGEHDASRR 460
Query: 479 ATLNAFLYRTGQHS---NKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRM 535
+ G S ++ +++ A+N+P++ D A+ R + V+ LP +E R L++
Sbjct: 461 LKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKN 520
Query: 536 YFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLA 582
K P T+ ++ +++AR+T+G SG ++ LA
Sbjct: 521 LLCKQG-SPLTQ-------------KELAQLARMTDGYSGSDLTALA 553
>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
Length = 403
Score = 65.1 bits (157), Expect = 2e-10
Identities = 81/368 (22%), Positives = 161/368 (43%), Gaps = 50/368 (13%)
Query: 256 REQIR--LKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAK 313
REQ++ K E + L+++++ G + GE + + V AT +
Sbjct: 44 REQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKAT------------NGP 91
Query: 314 NATLVAGRFIEARLGKPSLVRETSRITVLEALRH-PIQVSRRLLSRPQDALEGVVLSP-- 370
+ R ++ KP R +T L +R+ P +V + + + V S
Sbjct: 92 RYVVGCRRQLDKSKLKPG-TRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIG 150
Query: 371 SLEARVRDIAIATRNTKKNRSLYRNI--------LMYGPPGTGKTLFAKKLALHSGMDY- 421
L ++R++ N L++ + L+YGPPGTGKTL A+ +A ++
Sbjct: 151 GLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFL 210
Query: 422 AIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED--LRA 479
+++ V E + ++F++A + ++F+DE DA +R +E S D ++
Sbjct: 211 KVVSSSIVDKYIGESARLIREMFNYAR-DHQPCIIFMDEIDAIGGRRFSEGTSADREIQR 269
Query: 480 TLNAFLYRTGQHS--NKFMLVLASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRM 535
TL L + ++ +++A+N+P+ D A+ R++ +H DLP ++ R ++++
Sbjct: 270 TLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKI 329
Query: 536 YFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY-ASED 594
+ P T K + DY + +L++G +G ++ + A A D
Sbjct: 330 H-----AGPIT------KHGEIDY----EAIVKLSDGFNGADLRNVCTEAGMFAIRADHD 374
Query: 595 GVLTEAMM 602
V+ E M
Sbjct: 375 FVVQEDFM 382
>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
Length = 444
Score = 63.5 bits (153), Expect = 6e-10
Identities = 61/245 (24%), Positives = 108/245 (44%), Gaps = 41/245 (16%)
Query: 390 RSLYRNILMYGPPGTGKTLFAKKLALHSGMD--YAIMTGGDVAPMGREGVTAMHKLFDWA 447
R+ +R IL++GPPGTGK+ AK +A + ++I + V+ E + LF A
Sbjct: 164 RTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLA 223
Query: 448 NTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---TGQHSNKFMLVLASNQP 504
++ ++F+DE D+ R +E SE R FL + G ++ +++ A+N P
Sbjct: 224 RENKPS-IIFIDEIDSLCGSR-SENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIP 281
Query: 505 EQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCS 564
D AI R + ++ LP R + +++ G + L + D+
Sbjct: 282 WVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHL----------GTTQNSLTEADF----R 327
Query: 565 EVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEG 624
E+ R T+G SG +I+ ++ +A+M V++ Q + K G
Sbjct: 328 ELGRKTDGYSGADISI---------------IVRDALM-----QPVRKVQSATHFKKVRG 367
Query: 625 PGRGD 629
P R D
Sbjct: 368 PSRAD 372
>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
Length = 439
Score = 63.2 bits (152), Expect = 7e-10
Identities = 51/214 (23%), Positives = 103/214 (48%), Gaps = 17/214 (7%)
Query: 360 QDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGM 419
Q+ +E +VL + + + ++ I + +LMYGPPGTGKTL A+ A +
Sbjct: 196 QELVEAIVLPMNHKEKFENLGIQPP---------KGVLMYGPPGTGKTLLARACAAQTKA 246
Query: 420 DYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKR-ATEKISE-D 476
+ + G + M +G + F A + ++F+DE DA KR +EK + +
Sbjct: 247 TFLKLAGPQLVQMFIGDGAKLVRDAFALAK-EKAPSIIFIDELDAIGTKRFDSEKAGDRE 305
Query: 477 LRATLNAFLYRTG--QHSNKFMLVLASNQPEQFDWAI--NDRINEMVHFDLPGQEERERL 532
++ T+ L + Q + + ++ A+N+ + D A+ + R++ + F +P +E R R+
Sbjct: 306 VQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARI 365
Query: 533 VRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEV 566
++++ K + P ++ + G +C V
Sbjct: 366 MQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAV 399
>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
Length = 437
Score = 62.8 bits (151), Expect = 9e-10
Identities = 52/195 (26%), Positives = 91/195 (46%), Gaps = 21/195 (10%)
Query: 390 RSLYRNILMYGPPGTGKTLFAKKLALHSGMD--YAIMTGGDVAPMGREGVTAMHKLFDWA 447
R+ +R IL++GPPGTGK+ AK +A + +++ + ++ E + LF+ A
Sbjct: 157 RTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELA 216
Query: 448 NTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---TGQHSNKFMLVLASNQP 504
+ ++F+DE D+ R E SE R FL + G +++ +++ A+N P
Sbjct: 217 R-QHKPSIIFIDEVDSLCGSR-NENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIP 274
Query: 505 EQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCS 564
D AI R + ++ LP + R ++ R++ G L
Sbjct: 275 WVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHL----------GSTPHNLTD----ANIH 320
Query: 565 EVARLTEGMSGREIA 579
E+AR TEG SG +I+
Sbjct: 321 ELARKTEGYSGADIS 335
>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
Length = 466
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/194 (27%), Positives = 92/194 (47%), Gaps = 16/194 (8%)
Query: 391 SLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANT 449
S ++ +L+YGPPGTGKTL AK +A + ++ + R + + LF+ A
Sbjct: 213 SPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARY 272
Query: 450 SRRGLLLFVDEADAFLRKRATEKISE---DLRATLNAFLYRTG-QHSNKFMLVL-ASNQP 504
+F+DE ++ + +R T E LR + G S + VL ASN P
Sbjct: 273 HAPS-TIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLP 331
Query: 505 EQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCS 564
+ D A+ R+ + + DLP +E R+ ++ + L P ++ + + +Y S
Sbjct: 332 WELDCAMLRRLEKRILVDLPSREARQAMIYHW-----LPPVSKSRALELHTELEY----S 382
Query: 565 EVARLTEGMSGREI 578
+++ TEG SG +I
Sbjct: 383 VLSQETEGYSGSDI 396
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 62.4 bits (150), Expect = 1e-09
Identities = 69/282 (24%), Positives = 119/282 (42%), Gaps = 64/282 (22%)
Query: 41 PAPKDKWSNFDPTGLERAAK--AARELEHSRYA----------------KDALNLAQMQE 82
PAP D L R + A +++H +Y K AL+ Q Q+
Sbjct: 590 PAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQ 649
Query: 83 QTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAV------------------------ 118
L L+Q LKMR+ +++ ++ + S+ G++
Sbjct: 650 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLD 709
Query: 119 -----------QTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTL 167
Q E+ + ++ E A +E E E+ + E++R Q EE +
Sbjct: 710 TTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEE---ERKRQEELRRQQEEILRRQ 766
Query: 168 SEETRQHQARAQYQDKLARQRYEDQLKQQ--QLLNEENLRKQEESVQKQEAMRRATVER- 224
EE R+ + +++LAR++ E+ L++Q Q + R++EE Q++EA+RR R
Sbjct: 767 QEEERKRRE----EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 822
Query: 225 -EMELRHKNEMLRVEAEARARAKAERENADITREQIRLKAAE 265
E E R + E+LR + E A+ E E A E+ RL+ E
Sbjct: 823 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 864
Score = 39.3 bits (90), Expect = 0.011
Identities = 51/231 (22%), Positives = 94/231 (40%), Gaps = 22/231 (9%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLL 103
K K + + E +A RE E + ++ L + QE+ L+ +Q+ + K R E
Sbjct: 725 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 781
Query: 104 HTLVWAWSLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEER 163
A R + + + +Q A + E + + E +R Q EE
Sbjct: 782 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEA 841
Query: 164 RKTLSEET----RQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 219
K EE R + R + +++ AR R+E+ EE RK+ E VQ+Q+ + R
Sbjct: 842 AKWAREEEEAQRRLEENRLRMEEEAARLRHEE---------EERKRKELE-VQRQKELMR 891
Query: 220 ATVEREMELRHKNEMLRVEAEARARAKA-----ERENADITREQIRLKAAE 265
+++ LR + + + A+ + + ++ N + Q L AE
Sbjct: 892 QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE 942
Score = 31.2 bits (69), Expect = 3.0
Identities = 24/116 (20%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 141 LQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN 200
L+E +E+ + + E +RK L + ++ R + Q + A +R + Q +QQQL
Sbjct: 855 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL-- 912
Query: 201 EENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITR 256
++ S Q++ A + + + L E E + R + R+ ++ +
Sbjct: 913 -AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 967
Score = 30.0 bits (66), Expect = 6.8
Identities = 35/159 (22%), Positives = 64/159 (40%), Gaps = 19/159 (11%)
Query: 56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRA 115
E AAK ARE E ++ + N +M+E+ +L + + + R E
Sbjct: 839 EEAAKWAREEEEAQRRLEE-NRLRMEEEAARLRHEEEERKRKEL---------------- 881
Query: 116 GAVQTQERLSGSASPEQVPAGECCALQEYEAAVE-QLKSEQIRAQAEERRKTLSEETRQH 174
VQ Q+ L +Q Q+ + + +L S Q S+ T
Sbjct: 882 -EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL 940
Query: 175 QARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 213
+ +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 941 AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 979
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 62.4 bits (150), Expect = 1e-09
Identities = 69/282 (24%), Positives = 119/282 (42%), Gaps = 64/282 (22%)
Query: 41 PAPKDKWSNFDPTGLERAAK--AARELEHSRYA----------------KDALNLAQMQE 82
PAP D L R + A +++H +Y K AL+ Q Q+
Sbjct: 617 PAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQ 676
Query: 83 QTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAV------------------------ 118
L L+Q LKMR+ +++ ++ + S+ G++
Sbjct: 677 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLD 736
Query: 119 -----------QTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTL 167
Q E+ + ++ E A +E E E+ + E++R Q EE +
Sbjct: 737 TTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEE---ERKRQEELRRQQEEILRRQ 793
Query: 168 SEETRQHQARAQYQDKLARQRYEDQLKQQ--QLLNEENLRKQEESVQKQEAMRRATVER- 224
EE R+ + +++LAR++ E+ L++Q Q + R++EE Q++EA+RR R
Sbjct: 794 QEEERKRRE----EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 849
Query: 225 -EMELRHKNEMLRVEAEARARAKAERENADITREQIRLKAAE 265
E E R + E+LR + E A+ E E A E+ RL+ E
Sbjct: 850 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 891
Score = 39.3 bits (90), Expect = 0.011
Identities = 51/231 (22%), Positives = 94/231 (40%), Gaps = 22/231 (9%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLL 103
K K + + E +A RE E + ++ L + QE+ L+ +Q+ + K R E
Sbjct: 752 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 808
Query: 104 HTLVWAWSLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEER 163
A R + + + +Q A + E + + E +R Q EE
Sbjct: 809 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEA 868
Query: 164 RKTLSEET----RQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 219
K EE R + R + +++ AR R+E+ EE RK+ E VQ+Q+ + R
Sbjct: 869 AKWAREEEEAQRRLEENRLRMEEEAARLRHEE---------EERKRKELE-VQRQKELMR 918
Query: 220 ATVEREMELRHKNEMLRVEAEARARAKA-----ERENADITREQIRLKAAE 265
+++ LR + + + A+ + + ++ N + Q L AE
Sbjct: 919 QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE 969
Score = 31.2 bits (69), Expect = 3.0
Identities = 24/116 (20%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 141 LQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN 200
L+E +E+ + + E +RK L + ++ R + Q + A +R + Q +QQQL
Sbjct: 882 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL-- 939
Query: 201 EENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITR 256
++ S Q++ A + + + L E E + R + R+ ++ +
Sbjct: 940 -AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 994
Score = 30.0 bits (66), Expect = 6.8
Identities = 35/159 (22%), Positives = 64/159 (40%), Gaps = 19/159 (11%)
Query: 56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRA 115
E AAK ARE E ++ + N +M+E+ +L + + + R E
Sbjct: 866 EEAAKWAREEEEAQRRLEE-NRLRMEEEAARLRHEEEERKRKEL---------------- 908
Query: 116 GAVQTQERLSGSASPEQVPAGECCALQEYEAAVE-QLKSEQIRAQAEERRKTLSEETRQH 174
VQ Q+ L +Q Q+ + + +L S Q S+ T
Sbjct: 909 -EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL 967
Query: 175 QARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 213
+ +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 968 AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 1006
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 62.4 bits (150), Expect = 1e-09
Identities = 69/282 (24%), Positives = 119/282 (42%), Gaps = 64/282 (22%)
Query: 41 PAPKDKWSNFDPTGLERAAK--AARELEHSRYA----------------KDALNLAQMQE 82
PAP D L R + A +++H +Y K AL+ Q Q+
Sbjct: 596 PAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQ 655
Query: 83 QTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAV------------------------ 118
L L+Q LKMR+ +++ ++ + S+ G++
Sbjct: 656 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLD 715
Query: 119 -----------QTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTL 167
Q E+ + ++ E A +E E E+ + E++R Q EE +
Sbjct: 716 TTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEE---ERKRQEELRRQQEEILRRQ 772
Query: 168 SEETRQHQARAQYQDKLARQRYEDQLKQQ--QLLNEENLRKQEESVQKQEAMRRATVER- 224
EE R+ + +++LAR++ E+ L++Q Q + R++EE Q++EA+RR R
Sbjct: 773 QEEERKRRE----EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 828
Query: 225 -EMELRHKNEMLRVEAEARARAKAERENADITREQIRLKAAE 265
E E R + E+LR + E A+ E E A E+ RL+ E
Sbjct: 829 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 870
Score = 39.3 bits (90), Expect = 0.011
Identities = 51/231 (22%), Positives = 94/231 (40%), Gaps = 22/231 (9%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLL 103
K K + + E +A RE E + ++ L + QE+ L+ +Q+ + K R E
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 787
Query: 104 HTLVWAWSLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEER 163
A R + + + +Q A + E + + E +R Q EE
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEA 847
Query: 164 RKTLSEET----RQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 219
K EE R + R + +++ AR R+E+ EE RK+ E VQ+Q+ + R
Sbjct: 848 AKWAREEEEAQRRLEENRLRMEEEAARLRHEE---------EERKRKELE-VQRQKELMR 897
Query: 220 ATVEREMELRHKNEMLRVEAEARARAKA-----ERENADITREQIRLKAAE 265
+++ LR + + + A+ + + ++ N + Q L AE
Sbjct: 898 QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE 948
Score = 31.2 bits (69), Expect = 3.0
Identities = 24/116 (20%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 141 LQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN 200
L+E +E+ + + E +RK L + ++ R + Q + A +R + Q +QQQL
Sbjct: 861 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL-- 918
Query: 201 EENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITR 256
++ S Q++ A + + + L E E + R + R+ ++ +
Sbjct: 919 -AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 973
Score = 30.0 bits (66), Expect = 6.8
Identities = 35/159 (22%), Positives = 64/159 (40%), Gaps = 19/159 (11%)
Query: 56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRA 115
E AAK ARE E ++ + N +M+E+ +L + + + R E
Sbjct: 845 EEAAKWAREEEEAQRRLEE-NRLRMEEEAARLRHEEEERKRKEL---------------- 887
Query: 116 GAVQTQERLSGSASPEQVPAGECCALQEYEAAVE-QLKSEQIRAQAEERRKTLSEETRQH 174
VQ Q+ L +Q Q+ + + +L S Q S+ T
Sbjct: 888 -EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL 946
Query: 175 QARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 213
+ +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 947 AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 985
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 62.4 bits (150), Expect = 1e-09
Identities = 69/282 (24%), Positives = 119/282 (42%), Gaps = 64/282 (22%)
Query: 41 PAPKDKWSNFDPTGLERAAK--AARELEHSRYA----------------KDALNLAQMQE 82
PAP D L R + A +++H +Y K AL+ Q Q+
Sbjct: 596 PAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQ 655
Query: 83 QTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAV------------------------ 118
L L+Q LKMR+ +++ ++ + S+ G++
Sbjct: 656 LALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLD 715
Query: 119 -----------QTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTL 167
Q E+ + ++ E A +E E E+ + E++R Q EE +
Sbjct: 716 TTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEE---ERKRQEELRRQQEEILRRQ 772
Query: 168 SEETRQHQARAQYQDKLARQRYEDQLKQQ--QLLNEENLRKQEESVQKQEAMRRATVER- 224
EE R+ + +++LAR++ E+ L++Q Q + R++EE Q++EA+RR R
Sbjct: 773 QEEERKRRE----EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 828
Query: 225 -EMELRHKNEMLRVEAEARARAKAERENADITREQIRLKAAE 265
E E R + E+LR + E A+ E E A E+ RL+ E
Sbjct: 829 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 870
Score = 39.3 bits (90), Expect = 0.011
Identities = 51/231 (22%), Positives = 94/231 (40%), Gaps = 22/231 (9%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLL 103
K K + + E +A RE E + ++ L + QE+ L+ +Q+ + K R E
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 787
Query: 104 HTLVWAWSLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEER 163
A R + + + +Q A + E + + E +R Q EE
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEA 847
Query: 164 RKTLSEET----RQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 219
K EE R + R + +++ AR R+E+ EE RK+ E VQ+Q+ + R
Sbjct: 848 AKWAREEEEAQRRLEENRLRMEEEAARLRHEE---------EERKRKELE-VQRQKELMR 897
Query: 220 ATVEREMELRHKNEMLRVEAEARARAKA-----ERENADITREQIRLKAAE 265
+++ LR + + + A+ + + ++ N + Q L AE
Sbjct: 898 QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE 948
Score = 31.2 bits (69), Expect = 3.0
Identities = 24/116 (20%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 141 LQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN 200
L+E +E+ + + E +RK L + ++ R + Q + A +R + Q +QQQL
Sbjct: 861 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL-- 918
Query: 201 EENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITR 256
++ S Q++ A + + + L E E + R + R+ ++ +
Sbjct: 919 -AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 973
Score = 30.0 bits (66), Expect = 6.8
Identities = 35/159 (22%), Positives = 64/159 (40%), Gaps = 19/159 (11%)
Query: 56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRA 115
E AAK ARE E ++ + N +M+E+ +L + + + R E
Sbjct: 845 EEAAKWAREEEEAQRRLEE-NRLRMEEEAARLRHEEEERKRKEL---------------- 887
Query: 116 GAVQTQERLSGSASPEQVPAGECCALQEYEAAVE-QLKSEQIRAQAEERRKTLSEETRQH 174
VQ Q+ L +Q Q+ + + +L S Q S+ T
Sbjct: 888 -EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL 946
Query: 175 QARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 213
+ +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 947 AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 985
>gi|31742536 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 62.0 bits (149), Expect = 2e-09
Identities = 43/145 (29%), Positives = 75/145 (51%), Gaps = 7/145 (4%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWANTSRR 452
+ IL++GPPGTGKTL K +A SG ++I + EG + LF A ++
Sbjct: 435 KGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVAR-CQQ 493
Query: 453 GLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR----TGQHSNKFMLVLASNQPEQFD 508
++F+DE D+ L +R + E R FL + T ++ ++V A+N+P++ D
Sbjct: 494 PAVIFIDEIDSLLSQRGDGE-HESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEID 552
Query: 509 WAINDRINEMVHFDLPGQEERERLV 533
A R+ + ++ LP R+++V
Sbjct: 553 EAARRRLVKRLYIPLPEASARKQIV 577
>gi|112789543 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 62.0 bits (149), Expect = 2e-09
Identities = 43/145 (29%), Positives = 75/145 (51%), Gaps = 7/145 (4%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWANTSRR 452
+ IL++GPPGTGKTL K +A SG ++I + EG + LF A ++
Sbjct: 435 KGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVAR-CQQ 493
Query: 453 GLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR----TGQHSNKFMLVLASNQPEQFD 508
++F+DE D+ L +R + E R FL + T ++ ++V A+N+P++ D
Sbjct: 494 PAVIFIDEIDSLLSQRGDGE-HESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEID 552
Query: 509 WAINDRINEMVHFDLPGQEERERLV 533
A R+ + ++ LP R+++V
Sbjct: 553 EAARRRLVKRLYIPLPEASARKQIV 577
>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
Length = 361
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 28/196 (14%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRR 452
+ +L+YGPPG GKTL AK A +G + + + E +F A +
Sbjct: 127 KGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA-IKLQ 185
Query: 453 GLLLFVDEADAFLRKRATEKISEDLRAT-------LNAFLYRTGQHSNKFMLVLASNQPE 505
++F+DE D+FLR R+ S D AT ++ + HS + +++ A+N+P+
Sbjct: 186 PSIIFIDEIDSFLRNRS----SSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQ 241
Query: 506 QFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSE 565
D AI R+ H + P ++RE ++++ LK D E
Sbjct: 242 DLDSAIMRRMPTRFHINQPALKQREAILKLI---------------LKNENVDRHVDLLE 286
Query: 566 VARLTEGMSGREIAQL 581
VA+ T+G SG ++ ++
Sbjct: 287 VAQETDGFSGSDLKEM 302
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 60.8 bits (146), Expect = 4e-09
Identities = 41/130 (31%), Positives = 69/130 (53%), Gaps = 3/130 (2%)
Query: 142 QEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNE 201
+E+ L+ E+ + Q EE ++ + + Q R + +L R+R E++ +QQ+L E
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 202 ENLR-KQEESVQKQEAMRRATVE-REMELRHKNEMLRVEAEARARAKAERENADITRE-Q 258
+ LR KQEE ++Q+ RR E RE + + + LR E E R + RE + RE Q
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363
Query: 259 IRLKAAEHRQ 268
+R + E R+
Sbjct: 364 LRREQEEERR 373
Score = 60.5 bits (145), Expect = 5e-09
Identities = 55/203 (27%), Positives = 95/203 (46%), Gaps = 21/203 (10%)
Query: 77 LAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQTQERLSGSASPEQVPAG 136
L + +EQ +LE+Q + R E L L R + +E+ EQ
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR--EQQERR 328
Query: 137 ECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQL--- 193
E Q+ E +QL+ EQ + ++ R+ EE R+ Q R + ++ +R E QL
Sbjct: 329 E----QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE----ERREQQLRRE 380
Query: 194 ----KQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAER 249
++QQL E+ LR++++ ++Q+ R + RE +LR + ++ R + E R K E+
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 250 ENADITREQIRLKAAEHRQTVLE 272
E REQ + E R+ L+
Sbjct: 441 ER----REQRLKREQEERRDWLK 459
Score = 57.4 bits (137), Expect = 4e-08
Identities = 56/213 (26%), Positives = 98/213 (46%), Gaps = 29/213 (13%)
Query: 79 QMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQTQERLSGSASPEQVPAGEC 138
+ +EQ L+ EQ+ + + RL+ L Q + R EQ E
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERL------------QQRLRSEQQLRREQEERREQ 548
Query: 139 CALQEYEAAVEQLKSEQ-IRAQAEERRKTL---SEETRQHQARAQYQDKLAR-------Q 187
+E E +EQ + EQ ++ + EERR L EE RQ + + + +++L + +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 188 RYEDQLKQQQLLN----EENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARA 243
R E + +++Q L EE R+Q ++QE R+ + RE + R + + R E E R
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 244 RAKAERENADITREQIRLKAAEHRQTVLESIRT 276
+ +RE+ + REQ A E ++ E I++
Sbjct: 669 EQRLKREHEEERREQ--ELAEEEQEQARERIKS 699
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/215 (23%), Positives = 97/215 (45%), Gaps = 22/215 (10%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLL 103
KD+ + L + R E R ++ L Q +EQ L E++++ + LE
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER---- 1078
Query: 104 HTLVWAWSLCRAGAVQTQERLSGSASPE----QVPAGECCALQEYEAAVEQLKSEQIRAQ 159
+ +Q +E PE Q +C +E + EQL E+ +
Sbjct: 1079 -------QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE---R 1128
Query: 160 AEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQ---QLLNEENLRKQEESVQKQEA 216
+ RR+ L + R+ + Q +++L R+ E + +Q+ Q EE L+++EE + ++E
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 217 MRRATVEREMELRHKNEMLRVEAEARARAKAEREN 251
+R ERE + R + E+ R + + R R + +R +
Sbjct: 1189 EKRRQ-ERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Score = 53.9 bits (128), Expect = 4e-07
Identities = 40/132 (30%), Positives = 69/132 (52%), Gaps = 9/132 (6%)
Query: 150 QLKSEQIRAQAEERRKTL---SEETRQHQARAQYQDKLARQRY--EDQLKQQQLLNEENL 204
+L+ E+ R Q E R + L EE R+ + + Q +++ +QR E QL+++Q E L
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 205 RKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERE---NADITREQI-R 260
K+EE + ++ R ++RE E R + R E + R K E+E + RE++ R
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609
Query: 261 LKAAEHRQTVLE 272
L+ E R+ L+
Sbjct: 610 LEQEERREQRLK 621
Score = 53.1 bits (126), Expect = 7e-07
Identities = 39/135 (28%), Positives = 70/135 (51%), Gaps = 13/135 (9%)
Query: 141 LQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN 200
LQ+ E + + + E+ R Q ER+ EE +Q + + +++ R+R E ++Q
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE---LERQYRK 1082
Query: 201 EENLRKQEESVQKQEAMRRATVEREMELRHKNE-------MLRVEAEARARAKAE---RE 250
EE L+++EE + ++E +R ERE + R + E +LR E E R R + E RE
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 251 NADITREQIRLKAAE 265
++ +E+ +L E
Sbjct: 1143 EEEVQQEEEQLLREE 1157
Score = 52.8 bits (125), Expect = 1e-06
Identities = 52/219 (23%), Positives = 99/219 (45%), Gaps = 19/219 (8%)
Query: 64 ELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQTQER 123
E E ++ Q +E LQ +Q+ R + W W L +
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQE-----RRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 124 LSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDK 183
+ A EQ+ E LQE E +++ + E+ R Q +ER+ E+ +Q + + +++
Sbjct: 890 YAKPALQEQLRK-EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 184 LARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNE-------MLR 236
R+R E +++Q ++ L+++EE + +E +R ERE + R + E +LR
Sbjct: 949 EKRRRQE---RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005
Query: 237 VEAEARARAKAERE---NADITREQIRLKAAEHRQTVLE 272
E E R R + ER+ ++ +E+ +L E + L+
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Score = 52.4 bits (124), Expect = 1e-06
Identities = 59/225 (26%), Positives = 96/225 (42%), Gaps = 29/225 (12%)
Query: 55 LERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCR 114
L R + RE + R + +EQ L+ EQQ + + E H
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE--------- 439
Query: 115 AGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQI--RAQAEERR----KTLS 168
QER EQ + +E EQ + +Q R Q EERR K
Sbjct: 440 ------QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 169 EETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMEL 228
EE R+ Q R + Q +R +++ ++Q+L +E + ++ ++ ++ +RR ER +L
Sbjct: 494 EERREQQERREQQ----LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 229 RHKNEMLRVEAEAR-ARAKAERENADITREQIRLKAAEHRQTVLE 272
+ E R+E E R R K E+E R+Q+ + E RQ L+
Sbjct: 550 LKREEEKRLEQERREQRLKREQEE---RRDQLLKREEERRQQRLK 591
Score = 49.7 bits (117), Expect = 8e-06
Identities = 48/179 (26%), Positives = 83/179 (46%), Gaps = 7/179 (3%)
Query: 79 QMQEQTLQLEQQSKLKMRL--EALSLLHTLVWAWSLCRAGAVQTQERLSGSASPEQVPAG 136
+ ++Q L+ EQ+ +L+ RL E + L + + + R S EQ
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 137 ECCALQEYEAAVEQ-LKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLK- 194
+ +E + EQ LK E+ + E+R K EE R+ Q A+ + + AR+R + ++
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 195 -QQQLLNEENLRKQE--ESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERE 250
Q QL +E + R+ + +KQE RR + E R ++E+ E E R + E E
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Score = 48.9 bits (115), Expect = 1e-05
Identities = 37/134 (27%), Positives = 69/134 (51%), Gaps = 10/134 (7%)
Query: 142 QEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQ-RYEDQLK-QQQLL 199
QE E +QL+ EQ + E++ + + R+ Q R + Q + +Q R E QL+ +QQL
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 200 NEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEAR-----ARAKAERENADI 254
E+ LR++++ ++QE R E++ E + + L+ E E R + ER +
Sbjct: 415 REQQLRREQQLRREQEEERH---EQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 255 TREQIRLKAAEHRQ 268
++Q++ E R+
Sbjct: 472 RKQQLKRDQEEERR 485
Score = 47.8 bits (112), Expect = 3e-05
Identities = 54/230 (23%), Positives = 93/230 (40%), Gaps = 55/230 (23%)
Query: 55 LERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCR 114
LE K R H+ YAK AL +EQ L E++ +L
Sbjct: 878 LEEERKRRR---HTLYAKPALQEQLRKEQQLLQEEEEEL--------------------- 913
Query: 115 AGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERR----KTLSEE 170
Q +ER ++ E LQ+ E + + + E+ R Q ER+ K L ++
Sbjct: 914 ----QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 171 TRQ------HQARAQYQDKLARQRYEDQLKQQQLLNEEN-----------------LRKQ 207
Q + R Q ++K R+ E Q +++QLL EE L+++
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 208 EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITRE 257
EE + ++E +R ERE + R + E+ + E + + R ++ R+
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079
Score = 47.4 bits (111), Expect = 4e-05
Identities = 51/231 (22%), Positives = 100/231 (43%), Gaps = 16/231 (6%)
Query: 57 RAAKAARELEHSR---YAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLC 113
R + ++L H R + ++ L + +EQ L+ +++ + K R E L L
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-KFREEEQQLRRQERERKFLQ 1711
Query: 114 RAGAVQTQERLSGSASPEQV-PAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETR 172
++ QE EQ+ E L+ E + L+ EQ+R + EE++ E R
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771
Query: 173 QHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATV---EREMELR 229
+ + Q + + Q+ Q ++ EE LR++ E Q + R E +++L
Sbjct: 1772 KFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE 1831
Query: 230 HKNEMLRVEAEARARA--------KAERENADITREQIRLKAAEHRQTVLE 272
+ + LR E + + RA K+ RE ++ +E+ + + E + + E
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/254 (23%), Positives = 99/254 (38%), Gaps = 41/254 (16%)
Query: 55 LERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQS------------------KLKMR 96
L + R E R ++ L Q +EQ L+ EQ+ K K R
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 97 LEALSLLHTLVWAWSLCRAGAVQTQERLSGSASPEQVPAGECCALQEYEAA--VEQLKSE 154
L W W + AV+ + EQ E L++ ++ ++ L E
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273
Query: 155 QIRAQAEERRKTLSEETRQHQARAQYQ---DKLARQRYEDQLKQQQLLNEEN-------- 203
Q E+ R+ + R Q + K A++R +++QLL EE
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 204 ----LRKQEESVQKQEA--MRRATVER---EMELRHKNEMLRVEAEARARAKAERENADI 254
R++E+ +Q++E +RR +R E ELRH+ + + E + + ERE +
Sbjct: 1334 TDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFL 1393
Query: 255 TREQIRLKAAEHRQ 268
EQ +L+ E Q
Sbjct: 1394 KEEQ-QLRCQEREQ 1406
Score = 46.2 bits (108), Expect = 9e-05
Identities = 39/140 (27%), Positives = 70/140 (50%), Gaps = 16/140 (11%)
Query: 149 EQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQ-----LLNEEN 203
+QL+ ++ R EE + L +E + Q R Q +D+ R+ E QL++Q+ L E+
Sbjct: 1659 QQLRHDRDRKFREEEQ--LLQEGEEQQLRRQERDRKFREE-EQQLRRQERERKFLQEEQQ 1715
Query: 204 LRKQE--ESVQKQEAMRRATVEREMELRHK------NEMLRVEAEARARAKAERENADIT 255
LR+QE +++E +R+ T + ++ + + E LR E E + + ER+
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 256 REQIRLKAAEHRQTVLESIR 275
EQ+R + E + ES R
Sbjct: 1776 EEQLRQEREEQQLRSQESDR 1795
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/226 (25%), Positives = 97/226 (42%), Gaps = 11/226 (4%)
Query: 55 LERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCR 114
LE + R+ ++ K+ L + QE+ QL Q K R E L
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQL-RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE 1435
Query: 115 AGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEET--- 171
V+ QER EQ E E + Q + EQ + E RK L EE
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 172 RQHQARAQYQDKLARQRYEDQL--KQQQLLNEENLRK---QEESVQKQEAMRRATVEREM 226
RQ + R + +L Q E + ++QQL ++ RK +E+ +++QE ++ +R+
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 227 ELRHKNEMLRVEAEARARAKAERENADITREQIRLKAAEHRQTVLE 272
+ R + E LR E E + ++ ER+ EQ +++ E + +E
Sbjct: 1556 KFR-EEEQLRQEREEQQLSRQERDRKFRLEEQ-KVRRQEQERKFME 1599
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/236 (23%), Positives = 103/236 (43%), Gaps = 44/236 (18%)
Query: 56 ERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRA 115
E K R+ +Y ++ L Q +EQ L+ E++ + + W +
Sbjct: 976 EEPEKRRRQEREKKYREEE-ELQQEEEQLLREEREKRRRQE-----------WERQYRKK 1023
Query: 116 GAVQTQERLSGSASPEQVPAGECCALQEYEAAV---EQLKSEQIRAQAEER----RKTLS 168
+Q +E E+ LQE E E+L+ E+ + EER R+ L
Sbjct: 1024 DELQQEEEQLLREEREKR------RLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077
Query: 169 EETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVER---- 224
+ R+ + Q +++L R+ E + +Q++ E R++EE Q++E + R E+
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQER---ERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 225 EMELRHKNE---------MLRVEAEARARAKAE---RENADITREQIRLKAAEHRQ 268
E+E +++ E +LR E E R R + E RE ++ +E+ +L E +
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Score = 44.3 bits (103), Expect = 3e-04
Identities = 36/133 (27%), Positives = 66/133 (49%), Gaps = 11/133 (8%)
Query: 145 EAAVEQLKSEQIRA-QAEERRKTLSEET--RQHQARAQYQDKLARQRYEDQLKQQQLLNE 201
E +Q + Q R Q EE ++ ET R+ + + Q ++ ++ +++ +Q + L
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 202 ENLRKQ-EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITR--EQ 258
+ LR++ +E Q+Q+ +R RE +LR K E R E + R + ER R +Q
Sbjct: 284 QELRRERQEEEQQQQRLR-----REQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338
Query: 259 IRLKAAEHRQTVL 271
+R + E R+ L
Sbjct: 339 LRREQEERREQQL 351
Score = 43.5 bits (101), Expect = 6e-04
Identities = 46/215 (21%), Positives = 94/215 (43%), Gaps = 30/215 (13%)
Query: 63 RELEHSRYAKDALNLAQMQEQTLQ--------LEQQSKLKMRLEALSLLHTLVWAWSLCR 114
R+ ++ +D L + +EQ L LE++ +L+ + L H R
Sbjct: 1614 RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD--------R 1665
Query: 115 AGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQH 174
+ +E+L +Q+ QE + + + +Q+R Q ER+ E+ +
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRR------QERDRKFRE-EEQQLRRQERERKFLQEEQQLRR 1718
Query: 175 QA---RAQYQDKLARQRYEDQLKQQQ----LLNEENLRKQEESVQKQEAMRRATVEREME 227
Q + + +++L ++ ++QL++Q+ +L EE LR + E Q + R E +
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 228 LRHKNEMLRVEAEARARAKAERENADITREQIRLK 262
LR + E ++ ++ R E E RE+ +L+
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR 1813
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/154 (26%), Positives = 75/154 (48%), Gaps = 28/154 (18%)
Query: 141 LQEYEAAVEQLKSEQIRAQAEERRKTLSEET---RQHQARAQYQDKLARQRYEDQLKQ-- 195
L+ E + L+ EQ + + +RK L EE RQ + + + QD+ + R E+QL+Q
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 196 --QQL----------LNEENLRKQEES---------VQKQEAMRRATVEREMELRHKNEM 234
QQL L E+ +R+QE+ +++QE ++ ER+ + R ++
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 235 LRVEAEARARAKAERENADITRE-QIRLKAAEHR 267
L+ E E + + ER+ + E Q+R + E +
Sbjct: 1628 LQ-EREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 142 QEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNE 201
+E E +++ + + +R Q +R+ E Q Q R +++ QR Q ++++ L E
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE---QRLRRQERERKFLKE 1395
Query: 202 EN-LRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITREQIR 260
E LR QE Q ++ R E E +L + + E + + ERE + EQ +
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ-Q 1454
Query: 261 LKAAEHRQ 268
L+ HR+
Sbjct: 1455 LRQERHRK 1462
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/130 (29%), Positives = 63/130 (48%), Gaps = 16/130 (12%)
Query: 141 LQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLK--QQQL 198
L+ E + L+ EQ + E RK L EE Q R Q +++ RQ + + + +QQL
Sbjct: 1367 LRHQEQGRKFLEEEQRLRRQERERKFLKEE---QQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 199 LNEE---NLRKQEESVQKQEAMRRATVEREMELR-------HKNEMLRVEAEARARAKAE 248
+E R++E+ V++QE R+ +E E +LR + E L E E + + E
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERK-FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 249 RENADITREQ 258
R+ + EQ
Sbjct: 1483 RDRKFLEEEQ 1492
Score = 41.6 bits (96), Expect = 0.002
Identities = 47/216 (21%), Positives = 89/216 (41%), Gaps = 26/216 (12%)
Query: 55 LERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCR 114
L + R E R ++ L Q +EQ L+ E++ + + LE
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER-----------QYRE 1142
Query: 115 AGAVQTQERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQH 174
VQ +E PE+ E L+ E+L+ E+ + EE+ K E RQ+
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQE---LERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 175 QARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEM 234
+ + Q + +QRY D+ ++ L K + +K+ A+R V + +NE
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDL-------KWQWEPEKENAVRDNKVYCK---GRENEQ 1249
Query: 235 LRVEAEARARAKAERENAD--ITREQIRLKAAEHRQ 268
R +++ R + +++ + +Q R + E R+
Sbjct: 1250 FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/141 (29%), Positives = 65/141 (46%), Gaps = 25/141 (17%)
Query: 152 KSEQIRAQAEER--------RKTLSEE---TRQHQARAQYQDKLARQRYEDQL----KQQ 196
+ EQ+ + EE+ RK L EE RQ + + D+ + R E+QL ++Q
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 197 QLLNEE---NLRKQEESVQKQEAMRRATVE----REMELRHK---NEMLRVEAEARARAK 246
QL +E R++E+ +++QE R+ E R EL K E LR E E +
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Query: 247 AERENADITREQIRLKAAEHR 267
ER + EQ+R + E +
Sbjct: 1743 QERYRKILEEEQLRPEREEQQ 1763
Score = 40.4 bits (93), Expect = 0.005
Identities = 47/213 (22%), Positives = 88/213 (41%), Gaps = 21/213 (9%)
Query: 79 QMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQTQERLSGSASPEQ------ 132
+ ++Q L+ EQQ + + RL+ L L R + +E+ EQ
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERL--EQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 133 --VPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQ--DKLARQR 188
+P + E +A ++ S + + + RR+ E+ R+ ++ Q+Q ++ RQ+
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 189 YEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLR--------VEAE 240
E++ ++ + K E Q+ A +RE +LR + R E E
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 241 ARARAKAERE-NADITREQIRLKAAEHRQTVLE 272
R R + ERE E+ +L+ E Q + E
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/121 (25%), Positives = 59/121 (48%), Gaps = 6/121 (4%)
Query: 150 QLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEEN--LRKQ 207
+ + E++R Q E+ RK L EE R + + + Q+ Q ++QQL + + R++
Sbjct: 1361 KFREEELRHQ-EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE 1419
Query: 208 EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADITREQIRLKAAEHR 267
E+ + +QE R+ E + R + E +E E + R + R+ E+ L+ E +
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK---FREEEQLLQEREEQ 1476
Query: 268 Q 268
Q
Sbjct: 1477 Q 1477
Score = 40.4 bits (93), Expect = 0.005
Identities = 43/149 (28%), Positives = 69/149 (46%), Gaps = 29/149 (19%)
Query: 150 QLKSEQIRAQAEERRKTLSEE-------------------TRQHQARAQYQDKLARQRYE 190
+ + +++R+Q E RK L EE RQ + + + QD+ + R E
Sbjct: 1502 KFREQELRSQ-EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560
Query: 191 DQLKQ----QQLLNEENLRK---QEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARA 243
+QL+Q QQL +E RK +E+ V++QE R +E E +LR + ++ E R
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQE-QERKFMEDEQQLRRQEGQQQLRQE-RD 1618
Query: 244 RAKAERENADITREQIRLKAAEHRQTVLE 272
R E E RE+ +L E + LE
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLE 1647
Score = 39.3 bits (90), Expect = 0.011
Identities = 25/101 (24%), Positives = 52/101 (51%), Gaps = 2/101 (1%)
Query: 149 EQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLK-QQQLLNEENLRKQ 207
EQL+ E+ Q +++ + Q + + Q++ RQ + Q + ++Q +E R++
Sbjct: 1801 EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE 1860
Query: 208 EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAE 248
E+ + ++E +R ERE +LR ++ + + E R R E
Sbjct: 1861 EQELWQEEEQKRRQ-ERERKLREEHIRRQQKEEQRHRQVGE 1900
Score = 37.7 bits (86), Expect = 0.033
Identities = 46/214 (21%), Positives = 87/214 (40%), Gaps = 31/214 (14%)
Query: 63 RELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQTQE 122
R + R ++ L Q +E+ Q+ K RLE + ++ ++
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ------ERKFMEDEQ 1602
Query: 123 RLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQD 182
+L +Q+ +E E +++ + +Q+ Q E RK L EE +
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ-ERDRKFLEEEPQ---------- 1651
Query: 183 KLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEAR 242
L RQ E QL+ + + R++E+ +Q+ E + ER+ + R + + LR
Sbjct: 1652 -LRRQEREQQLRHDR---DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR------ 1701
Query: 243 ARAKAERENADITRE-QIRLKAAEHRQTVLESIR 275
+ ERE + E Q+R + E + E +R
Sbjct: 1702 ---RQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Score = 37.0 bits (84), Expect = 0.056
Identities = 46/227 (20%), Positives = 90/227 (39%), Gaps = 30/227 (13%)
Query: 63 RELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQTQE 122
R+ E R ++ + +E LQ +++ + + + W W + + ++
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ-AEEKSERGRQ 782
Query: 123 RLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTL-----------SEET 171
RLS + + A + + L E+ + E+RR+ EE
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEE---EKEQRRRQRREREKELQFLEEEEQ 839
Query: 172 RQHQARAQ--------YQDKLARQRYEDQLKQQQ---LLNEENLRKQEESVQKQEAMRRA 220
Q + RAQ Q+ R+R ++Q + Q+ L EE R++ K +
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 221 TVEREMELRHKNEMLRVEAEARARAKAERENADITREQIRLKAAEHR 267
E+++ + E+ R E E R R + ER+ RE+ +L+ E +
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQ----YREEEQLQQEEEQ 942
Score = 30.0 bits (66), Expect = 6.8
Identities = 25/117 (21%), Positives = 52/117 (44%), Gaps = 13/117 (11%)
Query: 145 EAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENL 204
E+ ++ + E+ + + E R + L EE Q R+R + Q ++++L E
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQ------------RRRQKRQEQERELAEGEEQ 154
Query: 205 RKQEESVQKQEAMRR-ATVEREMELRHKNEMLRVEAEARARAKAERENADITREQIR 260
+++E +++++ RR + R+ + + E R E E K EQ+R
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211
>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 60.8 bits (146), Expect = 4e-09
Identities = 49/202 (24%), Positives = 85/202 (42%), Gaps = 26/202 (12%)
Query: 390 RSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWAN 448
R ++ +LM GPPGTGKT+ AK +A G + ++ + R E + LF+ A
Sbjct: 238 RRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR 297
Query: 449 TSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---------TGQHSNKFMLVL 499
+F+DE D+ +R T E R + L + S M++
Sbjct: 298 -FYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLA 356
Query: 500 ASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDY 559
A+N P D A+ R+ + ++ LP + R L+++ L+ + D
Sbjct: 357 ATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKI---------------NLREVELDP 401
Query: 560 GRKCSEVARLTEGMSGREIAQL 581
+ ++A EG SG +I +
Sbjct: 402 DIQLEDIAEKIEGYSGADITNV 423
>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 60.8 bits (146), Expect = 4e-09
Identities = 49/202 (24%), Positives = 85/202 (42%), Gaps = 26/202 (12%)
Query: 390 RSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWAN 448
R ++ +LM GPPGTGKT+ AK +A G + ++ + R E + LF+ A
Sbjct: 238 RRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR 297
Query: 449 TSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---------TGQHSNKFMLVL 499
+F+DE D+ +R T E R + L + S M++
Sbjct: 298 -FYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLA 356
Query: 500 ASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDY 559
A+N P D A+ R+ + ++ LP + R L+++ L+ + D
Sbjct: 357 ATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKI---------------NLREVELDP 401
Query: 560 GRKCSEVARLTEGMSGREIAQL 581
+ ++A EG SG +I +
Sbjct: 402 DIQLEDIAEKIEGYSGADITNV 423
>gi|6005942 valosin-containing protein [Homo sapiens]
Length = 806
Score = 60.5 bits (145), Expect = 5e-09
Identities = 50/192 (26%), Positives = 87/192 (45%), Gaps = 20/192 (10%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRR 452
R IL+YGPPGTGKTL A+ +A +G + ++ G ++ + + E + + K F+ A +
Sbjct: 239 RGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAP 298
Query: 453 GLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVL-ASNQPEQFDWAI 511
++F+DE DA KR + R G ++V+ A+N+P D A+
Sbjct: 299 A-IIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPAL 357
Query: 512 N--DRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARL 569
R + V +P R +++++ + +KLA +VA
Sbjct: 358 RRFGRFDREVDIGIPDATGRLEILQIH------------TKNMKLAD---DVDLEQVANE 402
Query: 570 TEGMSGREIAQL 581
T G G ++A L
Sbjct: 403 THGHVGADLAAL 414
Score = 52.4 bits (124), Expect = 1e-06
Identities = 45/201 (22%), Positives = 92/201 (45%), Gaps = 35/201 (17%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRR 452
+ +L YGPPG GKTL AK +A ++ + G ++ M E + ++FD A +
Sbjct: 512 KGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQA-A 570
Query: 453 GLLLFVDEADAFLRKR---------ATEKISEDLRATLNAFLYRTGQHSNKFMLVL-ASN 502
+LF DE D+ + R A +++ + ++ G + K + ++ A+N
Sbjct: 571 PCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMD------GMSTKKNVFIIGATN 624
Query: 503 QPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYG 560
+P+ D AI R++++++ LP ++ R ++ K L+ +
Sbjct: 625 RPDIIDPAILRPGRLDQLIYIPLPDEKSRVAIL---------------KANLRKSPVAKD 669
Query: 561 RKCSEVARLTEGMSGREIAQL 581
+A++T G SG ++ ++
Sbjct: 670 VDLEFLAKMTNGFSGADLTEI 690
>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
Length = 773
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/209 (28%), Positives = 94/209 (44%), Gaps = 23/209 (11%)
Query: 392 LYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTS 450
L + IL+ GPPGTGKTL A+ +A + + + +G + M G + + LF A +
Sbjct: 371 LPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAK-A 429
Query: 451 RRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR-TGQHSNKFMLVL-ASNQPEQFD 508
++F+DE D+ KR + R T+N L G N+ ++++ A+N PE D
Sbjct: 430 NAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALD 489
Query: 509 WAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEV 566
A+ R + V P + R +++ Y +K +FD +
Sbjct: 490 NALIRPGRFDMQVTVPRPDVKGRTEILKWYLNK---------------IKFDQSVDPEII 534
Query: 567 ARLTEGMSGREIAQLAVSWQATAYASEDG 595
AR T G SG E+ L QA A+ DG
Sbjct: 535 ARGTVGFSGAELENLVN--QAALKAAVDG 561
>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
Length = 716
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/209 (28%), Positives = 94/209 (44%), Gaps = 23/209 (11%)
Query: 392 LYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTS 450
L + IL+ GPPGTGKTL A+ +A + + + +G + M G + + LF A +
Sbjct: 314 LPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAK-A 372
Query: 451 RRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR-TGQHSNKFMLVL-ASNQPEQFD 508
++F+DE D+ KR + R T+N L G N+ ++++ A+N PE D
Sbjct: 373 NAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALD 432
Query: 509 WAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEV 566
A+ R + V P + R +++ Y +K +FD +
Sbjct: 433 NALIRPGRFDMQVTVPRPDVKGRTEILKWYLNK---------------IKFDQSVDPEII 477
Query: 567 ARLTEGMSGREIAQLAVSWQATAYASEDG 595
AR T G SG E+ L QA A+ DG
Sbjct: 478 ARGTVGFSGAELENLVN--QAALKAAVDG 504
>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
Length = 491
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/156 (27%), Positives = 70/156 (44%), Gaps = 11/156 (7%)
Query: 390 RSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWAN 448
R ++ +LM GPPGTGKTL AK +A + ++ + R E + LF+ A
Sbjct: 239 RRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR 298
Query: 449 TSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---------TGQHSNKFMLVL 499
+F+DE D+ +R T + E R L + S M++
Sbjct: 299 FYSPA-TIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLA 357
Query: 500 ASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRM 535
A+N P D A+ R+ + ++ LP + RE L+R+
Sbjct: 358 ATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRI 393
>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
Length = 406
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/180 (28%), Positives = 87/180 (48%), Gaps = 11/180 (6%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 452
+ +L+YGPPGTGKTL A+ +A H+ + ++G + V EG + +LF A
Sbjct: 184 KGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAR-EHA 242
Query: 453 GLLLFVDEADAFLRKR---ATEKISEDLRATLNAFLYRTGQHSNK-FMLVLASNQPEQFD 508
++F+DE D+ R + SE R L G + K +++A+N+ + D
Sbjct: 243 PSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILD 302
Query: 509 WAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEV 566
A+ RI+ + F P +E R +++++ K L T G K+A+ G +EV
Sbjct: 303 SALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNL---TRGINLRKIAELMPGASGAEV 359
>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
Length = 893
Score = 57.8 bits (138), Expect = 3e-08
Identities = 43/143 (30%), Positives = 76/143 (53%), Gaps = 8/143 (5%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 452
R +L+YGPPGTGKT+ A+ +A G +++ G + ++ E + ++F A T R
Sbjct: 388 RGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA-TLRH 446
Query: 453 GLLLFVDEADAFLRKR--ATEKISEDLRATLNAFLYRTGQH-SNKFMLVL-ASNQPEQFD 508
++F+DE DA KR A ++ + + A+L + G S +LVL A+N+P D
Sbjct: 447 PSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALD 506
Query: 509 WAIN--DRINEMVHFDLPGQEER 529
A+ R ++ + +P ++R
Sbjct: 507 AALRRPGRFDKEIEIGVPNAQDR 529
Score = 54.3 bits (129), Expect = 3e-07
Identities = 53/223 (23%), Positives = 96/223 (43%), Gaps = 24/223 (10%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVA-PMGREGVTAMHKLFDWANTSRR 452
+ +L+YGPPG KT+ AK LA SG+++ + G ++ E A+ + F A
Sbjct: 662 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAP 721
Query: 453 GLLLFVDEADAFLRKRATEKISEDL--RATLNAFLYRTGQHSNKFMLVL-ASNQPEQFDW 509
++ F DE DA +R + + ++ R G K + +L A+N+P++ D
Sbjct: 722 SIIFF-DELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
Query: 510 AI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVA 567
A+ RI+ +++ LP R + ++ F + + E+
Sbjct: 781 ALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVD---------------LDELI 825
Query: 568 RLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAV 610
T+ SG EI +AV +A A E+ + +M A+
Sbjct: 826 LQTDAYSGAEI--VAVCREAALLALEEDIQANLIMKRHFTQAL 866
>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
Length = 433
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/150 (28%), Positives = 73/150 (48%), Gaps = 8/150 (5%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 452
+ +L++GPPGTGKTL A+ +A + + + G + V EG + +LF+ A T ++
Sbjct: 210 KGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMART-KK 268
Query: 453 GLLLFVDEADAFLRKRATEKISED---LRATLNAFLYRTG-QHSNKFMLVLASNQPEQFD 508
L+F DE DA R + D R L G +++A+N+P+ D
Sbjct: 269 ACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLD 328
Query: 509 WAI--NDRINEMVHFDLPGQEERERLVRMY 536
A+ R++ + F LP E R + +++
Sbjct: 329 PALMRPGRLDRKIEFSLPDLEGRTHIFKIH 358
>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
Length = 750
Score = 56.2 bits (134), Expect = 9e-08
Identities = 52/197 (26%), Positives = 89/197 (45%), Gaps = 27/197 (13%)
Query: 394 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 452
R +L++GPPG GKTL A +A + + + V+ + E + +LF+ A S
Sbjct: 193 RGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQA-VSNA 251
Query: 453 GLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSN------KFMLVLASNQPEQ 506
++F+DE DA KR E S+D+ + A L N + +++ A+N+P+
Sbjct: 252 PCIIFIDEIDAITPKR--EVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDS 309
Query: 507 FDWAIN--DRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCS 564
D A+ R + + +P + RER+++ K L A FD+
Sbjct: 310 LDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQA-----------FDF----C 354
Query: 565 EVARLTEGMSGREIAQL 581
+A LT G G ++ L
Sbjct: 355 HLAHLTPGFVGADLMAL 371
Score = 56.2 bits (134), Expect = 9e-08
Identities = 52/206 (25%), Positives = 91/206 (44%), Gaps = 6/206 (2%)
Query: 396 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTSRRGL 454
+L+ GPPG GKTL AK +A SG+++ + G ++ M E A+ ++F A S
Sbjct: 512 VLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNS-APC 570
Query: 455 LLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVL-ASNQPEQFDWAI-- 511
++F DE DA +R+ + +R G + + + ++ A+N+P+ D AI
Sbjct: 571 VIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILR 630
Query: 512 NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTE 571
R+++ + LP +R +++ K KP + L+ D C A L+
Sbjct: 631 PGRLDKTLFVGLPPPADRLAILKT-ITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSA 689
Query: 572 GMSGREIAQLAVSWQATAYASEDGVL 597
+ I L +E G L
Sbjct: 690 LVREASICALRQEMARQKSGNEKGEL 715
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,792,220
Number of Sequences: 37866
Number of extensions: 1120489
Number of successful extensions: 17050
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 320
Number of HSP's successfully gapped in prelim test: 713
Number of HSP's that attempted gapping in prelim test: 10818
Number of HSP's gapped (non-prelim): 4718
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.