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Search of human proteins with 40217825
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40217825 slit and trk like 6 [Homo sapiens]
(841 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40217825 slit and trk like 6 [Homo sapiens] 1701 0.0
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens] 625 e-179
gi|27436867 slit and trk like 4 protein [Homo sapiens] 619 e-177
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens] 587 e-167
gi|40217820 slit and trk like 3 protein [Homo sapiens] 530 e-150
gi|40217817 slit and trk like 1 protein [Homo sapiens] 501 e-141
gi|11321571 slit homolog 3 [Homo sapiens] 154 3e-37
gi|188528675 slit homolog 1 [Homo sapiens] 150 6e-36
gi|4759146 slit homolog 2 [Homo sapiens] 132 1e-30
gi|194440719 chondroadherin-like [Homo sapiens] 127 4e-29
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 103 9e-22
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 102 1e-21
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 102 2e-21
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 102 2e-21
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 100 7e-21
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 100 7e-21
gi|198041768 synleurin [Homo sapiens] 100 1e-20
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 100 1e-20
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 99 2e-20
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 98 3e-20
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 97 6e-20
gi|31542244 leucine rich repeat and fibronectin type III domain ... 95 3e-19
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 1701 bits (4404), Expect = 0.0
Identities = 841/841 (100%), Positives = 841/841 (100%)
Query: 1 MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS 60
MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS
Sbjct: 1 MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS 60
Query: 61 VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN 120
VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN
Sbjct: 61 VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN 120
Query: 121 HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF 180
HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF
Sbjct: 121 HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF 180
Query: 181 RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS 240
RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS
Sbjct: 181 RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS 240
Query: 241 IIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKT 300
IIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKT
Sbjct: 241 IIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKT 300
Query: 301 TSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP 360
TSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP
Sbjct: 301 TSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP 360
Query: 361 PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNG 420
PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNG
Sbjct: 361 PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNG 420
Query: 421 NHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFS 480
NHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFS
Sbjct: 421 NHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFS 480
Query: 481 GVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTV 540
GVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTV
Sbjct: 481 GVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTV 540
Query: 541 TDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS 600
TDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS
Sbjct: 541 TDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS 600
Query: 601 LTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSM 660
LTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSM
Sbjct: 601 LTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSM 660
Query: 661 YGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRS 720
YGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRS
Sbjct: 661 YGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRS 720
Query: 721 LLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIA 780
LLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIA
Sbjct: 721 LLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIA 780
Query: 781 QLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQ 840
QLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQ
Sbjct: 781 QLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQ 840
Query: 841 T 841
T
Sbjct: 841 T 841
>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
Length = 958
Score = 625 bits (1611), Expect = e-179
Identities = 357/915 (39%), Positives = 534/915 (58%), Gaps = 113/915 (12%)
Query: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNA 90
CD+ C CEEKDG + ++CE +GI +SEIS P + L L N L L+ N+F T A
Sbjct: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107
Query: 91 ISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITV 150
+HLG N I DIE GAF+GL L++LH+N+N LE+L++DTF GLENLE+LQ D N+I+V
Sbjct: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167
Query: 151 IEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRI 210
IEP+AF KL+ L+VLILNDN + SLP N+FRFVPLTHLDLRGN+L+ LPYVG L+H+ ++
Sbjct: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKV 227
Query: 211 LDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTP 270
++LQLE+N W C+C+L+ LK WL+++ +++GDVVC +P G L + K+ +CP
Sbjct: 228 VELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRR 287
Query: 271 PVYEEHEDP------SGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP---- 320
+ + P +G LH T+ + + ++T ++++ K P K P KP
Sbjct: 288 LISDYEMRPQTPLSTTGYLH---TTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRP 344
Query: 321 --------------------STQLPGPY-CPIPCNCKV-LSPSGLLIHCQERNIESLSDL 358
T+ P P CP C+C + +S GL ++CQER IES+++L
Sbjct: 345 TSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
Query: 359 RPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYL 418
+P P NP+K+ L N I + ++D +E L++LHLGNNRI ++++ +F +LT L++LYL
Sbjct: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
Query: 419 NGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHI 478
NGN + +LS +F GL +L+YL+L+YN I+EI GTF+P+P L++L+LNNNLLQ +P +
Sbjct: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
Query: 479 FSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKN 538
FSG+ L ++NL++N FT LPVS +LD L L QIDL DNPWDC+CD+VG++ W+++L
Sbjct: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
Query: 539 TVTDDILCTSPGHLDKKELKALNSEILCPG----LVNNPS-----MPTQTSYLMVTTPAT 589
+ D+++C +P + +++++ SE+LCP +V+ P+ +P +TS TPA
Sbjct: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTS---AVTPAV 641
Query: 590 TTNT----ADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVD 645
N+ A +VPLSVLIL LL++FI VF AAG+ VLV+ RR++ +
Sbjct: 642 RLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTS 701
Query: 646 EQMRDNSPVHLQYSMYG---------HKTTHHT------TERPSASLYEQHMVSPMVHVY 690
D S ++QYS+YG H HH + P+ +YE ++ P+ H+
Sbjct: 702 TNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYE-YIPHPLGHMC 760
Query: 691 RSPSFGPK----------------------HLEEEEE------RNEKEGSDAKHLQRSLL 722
++P + + HL+++++ + +++ LQ
Sbjct: 761 KNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEE 820
Query: 723 EQENHSPLTGSNMKYKTTNQSTEFLS-FQDASSLYRNILEKERELQQL----GITEYLR- 776
E+ L T + LS QDA YR ILE ++ + EY +
Sbjct: 821 ERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKF 880
Query: 777 ----------KNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKAN 826
N +P H PGA + +L E ++YS P V VE +NEY ELKA
Sbjct: 881 PCSPAAYTFSPNYDLRRPHQYLH-PGAGDS-RLREPVLYSPPSAVFVEPNRNEYLELKAK 938
Query: 827 LHAEPDYLEVLEQQT 841
L+ EPDYLEVLE+QT
Sbjct: 939 LNVEPDYLEVLEKQT 953
>gi|27436867 slit and trk like 4 protein [Homo sapiens]
Length = 837
Score = 619 bits (1596), Expect = e-177
Identities = 352/864 (40%), Positives = 501/864 (57%), Gaps = 55/864 (6%)
Query: 1 MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS 60
M LW+ L S+L++ + S V ++C+C + + +NCE + +++
Sbjct: 1 MFLWLFLILSALISSTNADSDISV-----EICNVCSCVSVENVLYVNCEKVSVYRPNQLK 55
Query: 61 VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN 120
P S + L+ NN L +L+ N F ++A+S+HLG N + +IE GAF GL LKQLH+N
Sbjct: 56 PPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLN 115
Query: 121 HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF 180
+N L+IL+ DTF G+ENLE+LQAD N I IE AF+KL++LKVLILNDN I LP NIF
Sbjct: 116 NNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIF 175
Query: 181 RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS 240
RF LTHLD+RGN++Q LPY+G LEHIGR+++LQLEDN W C+CDLL LK WLENMP
Sbjct: 176 RFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNI 235
Query: 241 IIGDVVCNSPPFFKGSILSRLKKESICPT-----------PPVYEEHEDPSGSLHLAATS 289
IG+ +C +P G +L K+ +CP PP E+ + + H TS
Sbjct: 236 YIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTS 295
Query: 290 SINDSRMSTKTTSILKLPTKAPG----------LIPYITKPSTQLPGPYCPIPCNCKVL- 338
KTT+ K+ G ++ Y T+ P CP PC CK
Sbjct: 296 LHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTP---CPAPCFCKTHP 352
Query: 339 SPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNR 398
S GL ++CQE+NI+S+S+L P P N +KL + GN I + SD ++ L++LHLG+N+
Sbjct: 353 SDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQ 412
Query: 399 IEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPM 458
I V++ F NLT L++LYLNGN + +L +F GLHNL+YLYLEYN IKEI GTF+ M
Sbjct: 413 ITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSM 472
Query: 459 PKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNP 518
P L++LYLNNNLL+ LP +IFSG PL ++NL+ N+F +LPVS +LD L LTQIDLE NP
Sbjct: 473 PNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNP 532
Query: 519 WDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQ 578
WDC+CDLV L+ W++KLS V ++ C +P ELK+L +EILCP L+N PS P
Sbjct: 533 WDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFT 592
Query: 579 TSYLMVTTPATTTNTADTILRSLTDA-VPLSVLILGLLIMFITIVFCAAGIVVLVLHRRR 637
+ PA T T +RS VPLS+LIL +L++ I VF A ++V VL R +
Sbjct: 593 S-----PAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNK 647
Query: 638 RYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGP 697
+ K D + LQ + HK T + E + + + +S + G
Sbjct: 648 KPTVKHEGLGNPDCGSMQLQLRKHDHK-----TNKKDGLSTEAFIPQTIEQMSKSHTCGL 702
Query: 698 KHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYR 757
K E ++ G K + R++ ++E + + T ++ E +D++ +
Sbjct: 703 KESETGFMFSDPPGQ--KVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
Query: 758 NILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTK 817
N LE ++E +G++ + E YP + K ++L+ K++VEQ K
Sbjct: 761 NFLESKKEYNSIGVSGF------------EIRYPEKQPDKKSKKSLIGGNHSKIVVEQRK 808
Query: 818 NEYFELKANLHAEPDYLEVLEQQT 841
+EYFELKA L + PDYL+VLE+QT
Sbjct: 809 SEYFELKAKLQSSPDYLQVLEEQT 832
>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 587 bits (1514), Expect = e-167
Identities = 346/860 (40%), Positives = 505/860 (58%), Gaps = 49/860 (5%)
Query: 7 LFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRP 66
+++ S+L + +++ C C CEEK+ + INCE KG VS + P R
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI 126
+QL L N LT L+ N+F +NA+++HLG N + +I GAF+GL LK+LH+N+N LEI
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 127 LKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLT 186
L+EDTF GLE+LE+LQAD N+I+ IE AFSKLN+LKVLILNDN + SLP N+FRFV LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
HLDLRGN+L+ +P+ G LEHIG I+++QLE+N W C CDLL LK WL+ + +G++V
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITV--FVGEIV 242
Query: 247 CNSPPFFKGSILSRLKKESICPTPPVYEEHEDPS-GSLHLAATS-SINDSRMSTKTTSIL 304
C +P G +++L ++ +CP + + S H+ S ++N + T+
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKAS 302
Query: 305 KLPTKAPGLIPYITKPS------------TQLPGPY-CPIPCNC-KVLSPSGLLIHCQER 350
+ P P +T T+ P P CP C C S +GL ++CQER
Sbjct: 303 RPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQER 362
Query: 351 NIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL 410
++SDL+P P +P+KL L GN + ++ K+DL+EY +L++LHLGNNRI V++EG+F NL
Sbjct: 363 KFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNL 422
Query: 411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNL 470
T L++LYLNGN+L L MF GL +L+YLYLEYN IKEI P TF+ + L++L+LNNNL
Sbjct: 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNL 482
Query: 471 LQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQ 530
L+ LP +IF G LT++NL+ N F+HLPV +LD L QIDL++NPWDC+CD++GL+
Sbjct: 483 LRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKD 542
Query: 531 WIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM--VTTPA 588
W + + + +++ C SP + LK L E +CP ++P++ T M T
Sbjct: 543 WTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP---DSPNLSDGTVLSMNHNTDTP 599
Query: 589 TTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQM 648
+ + + + L VPLSVLILGLL++FI V AG+ V VL RR+ +
Sbjct: 600 RSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNN 659
Query: 649 RDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEE-EEERN 707
D S LQY Y + TH T+ +Y ++ P+ + ++P + K + RN
Sbjct: 660 LDVSSFQLQYGSY-NTETHDKTD---GHVY-NYIPPPVGQMCQNPIYMQKEGDPVAYYRN 714
Query: 708 EKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQ----DASSLYRNILEKE 763
+E S S LE++ P T + T +TE L Q + LY+NI E+
Sbjct: 715 LQEFS------YSNLEEKKEEPATPA-----YTISATELLEKQATPREPELLYQNIAERV 763
Query: 764 RELQQLGITEYLRKNI--AQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYF 821
+EL G+ Y + Q P E+ + ++ +T++Y PRK V Q+K +
Sbjct: 764 KELPSAGLVHYNFCTLPKRQFAPSYESR---RQNQDRINKTVLYGTPRKCFVGQSKPNHP 820
Query: 822 ELKANLHAEPDYLEVLEQQT 841
L+A +EPDYLEVLE+QT
Sbjct: 821 LLQAKPQSEPDYLEVLEKQT 840
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 530 bits (1366), Expect = e-150
Identities = 306/831 (36%), Positives = 465/831 (55%), Gaps = 96/831 (11%)
Query: 3 LWIHLFYSSLLACISLHSQTPVLSSRGS------CDSLCNCEEKDGTMLINCEAKGIKMV 56
LWI LL+ I+L TP+ S C C CE K+ I+C++KG +
Sbjct: 15 LWI-----ILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNI 69
Query: 57 SEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQ 116
S+I+ SRPF+L L N + L+TN F L NA+SI+LG N + DI+ GAFNGL +LK+
Sbjct: 70 SQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKR 129
Query: 117 LHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLP 176
L+++ N L++ + DTF GLE+LE+LQAD N I IE AF L++L+VLILNDN I LP
Sbjct: 130 LYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLP 189
Query: 177 PNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGR-ILDLQLEDNKWACNCDLLQLKTWLEN 235
N+F+ V LTHLDLRGN+L+ L Y G L+HIGR +++LQLE+N W C C+++QLK+WLE
Sbjct: 190 TNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLER 249
Query: 236 MPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSR 295
+P +++GD+ C +P F G L ++K +CP + SL + +SS ++
Sbjct: 250 IPYTALVGDITCETPFHFHGKDLREIRKTELCPLL----SDSEVEASLGIPHSSSSKENA 305
Query: 296 MSTKTTSILKL------------------PTKAPG-------------------LIPYIT 318
TK +S+L PTK P + PY T
Sbjct: 306 WPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQT 365
Query: 319 KPSTQLPGPYCPIPCNCKV-LSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHS 377
+P + CP C C + ++ GL ++C+ER ++S+L P P N +KL L+ N+I
Sbjct: 366 RPPIPI---ICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQK 422
Query: 378 LMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNL 437
+ +SD + +L++LHLGNNRI +++G+F+NL L+ L+LNGN + KL+ GMF GL +L
Sbjct: 423 IYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSL 482
Query: 438 EYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHL 497
YLY E+N I+EI P F+ MP LK+L+LNNNLL+ LP F+G L ++NL+ N F +L
Sbjct: 483 HYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYL 542
Query: 498 PVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKEL 557
PV+ +L+ L+ + QIDL +NPWDC+CDLV +QWI+ +S +V D+LC SP +L +++
Sbjct: 543 PVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDV 602
Query: 558 KALNSEILCPGLVN------NPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLI 611
+ + E+LCP +++ +P+ P + + T A+ + VPLSVLI
Sbjct: 603 RTIELEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPP-----GGPVPLSVLI 657
Query: 612 LGLLIMFITIVFCAAGIVVLVLHRRRR---YKKKQVDEQMRDNSPVHLQYSMY------- 661
L LL++F + VF AAG+ VL RRR+ ++ K+ ++ D + + +Q
Sbjct: 658 LSLLVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKR--QEGVDLTGIQMQCHRLFEDGGGG 715
Query: 662 -------GHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDA 714
G T + P +++ P+ + +P + P+ EE + +E A
Sbjct: 716 GGGSGGGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAVSSAQEAGSA 775
Query: 715 KHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERE 765
+ L GS +T ++ S YR +LEKE+E
Sbjct: 776 ERGGPGTQPPGMGEALLGSEQFAETPKEN---------HSNYRTLLEKEKE 817
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/53 (45%), Positives = 35/53 (66%), Gaps = 1/53 (1%)
Query: 790 YPGAHEELKLMETLMYSRPRKVLVEQT-KNEYFELKANLHAEPDYLEVLEQQT 841
YP ++ +L ETL++S + QT K++Y EL+A L +PDYLEVLE+ T
Sbjct: 922 YPDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKLQTKPDYLEVLEKTT 974
>gi|40217817 slit and trk like 1 protein [Homo sapiens]
Length = 696
Score = 501 bits (1290), Expect = e-141
Identities = 282/686 (41%), Positives = 402/686 (58%), Gaps = 35/686 (5%)
Query: 1 MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS 60
M LWI L +SL C + + T + + +C+C E +G + ++CE KG + +
Sbjct: 1 MLLWILLLETSL--CFAAGNVTGDVCK----EKICSCNEIEGDLHVDCEKKGFTSLQRFT 54
Query: 61 VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN 120
P S+ + L L N LT L N+F+ NA+S+H+ N + +I GAF GL L+K+LHIN
Sbjct: 55 APTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHIN 114
Query: 121 HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF 180
+N ++ ++ TF GL++LE+LQAD N + I+P AF LN+L+VLILNDN I +LP N+F
Sbjct: 115 NNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVF 174
Query: 181 RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS 240
++VP+THLDLRGN+L+TLPY LE I I ++ LEDN W C CDLL LK WLEN+P +
Sbjct: 175 QYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNA 234
Query: 241 IIGDVVCNSPPFFKGSILSRLKKESIC----------PTPPVYEEHEDPSGSL------- 283
+IG VVC +P +G L+ ++ +C P PP EE P G L
Sbjct: 235 LIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAP-GPLPTPFKTN 293
Query: 284 ----HLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP-STQLPGPYCPIPCNCKVL 338
H S+ N I PT A KP + LP CP C+C +
Sbjct: 294 GQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLP---CPGGCSCDHI 350
Query: 339 SPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNR 398
SGL ++C RN+ SL+DL+P N ++L L N IHS+ KS V+Y L +L LGNN
Sbjct: 351 PGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNN 410
Query: 399 IEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPM 458
I +E +F NL L+ LY++ N+L LS+ F GL NLEYL +EYNAI+ ILPGTFN M
Sbjct: 411 IATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAM 470
Query: 459 PKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNP 518
PKL++L LNNNLL+ LP +F+GV L+K++L N F +LPV+ +LD L + QIDL NP
Sbjct: 471 PKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNP 530
Query: 519 WDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQ 578
W+CSC +V +QW ++L + D+ C +P + +K+ L+++ +CP L S PT
Sbjct: 531 WECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARIS-PTL 589
Query: 579 TSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRR 638
TS+ +T T T T V +SVL+ GLL++F+T F G++V +L R+R
Sbjct: 590 TSHSKNSTGLAETGTHSNSYLD-TSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKR 648
Query: 639 YKKKQVDEQMRD-NSPVHLQYSMYGH 663
K++ + + NS + S Y H
Sbjct: 649 SKRRDANSSASEINSLQTVCDSSYWH 674
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 154 bits (390), Expect = 3e-37
Identities = 139/553 (25%), Positives = 222/553 (40%), Gaps = 93/553 (16%)
Query: 13 LACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLL 72
LA S+ S P ++ C + C C ++C G++ V P +L L
Sbjct: 20 LALASVLSGPPAVA----CPTKCTCSAAS----VDCHGLGLRAVPRGI--PRNAERLDLD 69
Query: 73 NNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTF 132
N +T + DF+GL N +HL N ++ IE GAF L L++L +N N L++L E F
Sbjct: 70 RNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLF 129
Query: 133 HGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLR 191
L L N I I AF + +K L L++N I + FR + L L L
Sbjct: 130 QSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLN 189
Query: 192 GNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPP 251
N + + F H+ +I L+L N C+C L L WL +++ +C +P
Sbjct: 190 NNNISRILVTSF-NHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVGQFTLCMAPV 246
Query: 252 FFKG-SILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKA 310
+G ++ KKE +CP P H +P
Sbjct: 247 HLRGFNVADVQKKEYVCPAP-----HSEP------------------------------- 270
Query: 311 PGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLIL 370
PS CP PC C S ++ C+ + + + P+ ++ L
Sbjct: 271 ---------PSCNANSISCPSPCTC-----SNNIVDCRGKGLMEIP--ANLPEGIVEIRL 314
Query: 371 AGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM 430
N I ++ +Y L+ + + N+I + +F L L L L GN +T+++KG+
Sbjct: 315 EQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374
Query: 431 FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK 490
F GL +L+ L L N I + TF + L +L L +N LQ + +F+
Sbjct: 375 FDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFA---------- 424
Query: 491 TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG 550
L + + L NP+ C C L L ++Q T C+SP
Sbjct: 425 --------------PLQSIQTLHLAQNPFVCDCHLKWLADYLQ--DNPIETSGARCSSPR 468
Query: 551 HLDKKELKALNSE 563
L K + + S+
Sbjct: 469 RLANKRISQIKSK 481
Score = 129 bits (325), Expect = 9e-30
Identities = 143/604 (23%), Positives = 238/604 (39%), Gaps = 111/604 (18%)
Query: 15 CISLHSQTPVLSSRG-SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLN 73
C + HS+ P ++ SC S C C +++C KG+ + +P + P
Sbjct: 263 CPAPHSEPPSCNANSISCPSPCTCSNN----IVDCRGKGL-----MEIPANLP------- 306
Query: 74 NGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFH 133
+ I L N+I I GAF LK++ I+ N + + D F
Sbjct: 307 --------------EGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQ 352
Query: 134 GLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRG 192
GL++L L N IT I F L L++L+LN N I L N F+ + L L L
Sbjct: 353 GLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYD 412
Query: 193 NQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPF 252
N+LQT+ G + I L L N + C+C L L +L++ P ++ C+SP
Sbjct: 413 NKLQTISK-GLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET--SGARCSSPRR 469
Query: 253 FKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPG 312
+S++K + S D R + + L
Sbjct: 470 LANKRISQIKSKKF--------------------RCSGSEDYRSRFSSECFMDL------ 503
Query: 313 LIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAG 372
CP C C+ G ++ C + + + P + L L
Sbjct: 504 ---------------VCPEKCRCE-----GTIVDCSNQKLVRIPSHLP--EYVTDLRLND 541
Query: 373 NIIHSLMKSDLVEYF-TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMF 431
N + L + + + L ++L NN+I+ + EG+F +Q+L L GN L + +F
Sbjct: 542 NEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVF 601
Query: 432 LGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKT 491
GL L+ L L N I + TF + +++L L +N + + P F+ T V+L T
Sbjct: 602 RGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFT----TLVSLST 657
Query: 492 NQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGH 551
I+L NP++C+C L L +W++K + V+ + C P
Sbjct: 658 --------------------INLLSNPFNCNCHLAWLGKWLRK--RRIVSGNPRCQKPFF 695
Query: 552 LDKKELKALN-SEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVL 610
L + ++ + + C G + + T T ++ LR+L +P V
Sbjct: 696 LKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVT 755
Query: 611 ILGL 614
L L
Sbjct: 756 ELYL 759
Score = 99.0 bits (245), Expect = 2e-20
Identities = 108/442 (24%), Positives = 172/442 (38%), Gaps = 88/442 (19%)
Query: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH-TNDFSGLTN 89
C C CE GT++ K +++ S + P L L +N +++L T F L N
Sbjct: 505 CPEKCRCE---GTIVDCSNQKLVRIPSHL---PEYVTDLRLNDNEVSVLEATGIFKKLPN 558
Query: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
I+L N I ++ GAF+G +++L + N LE + F GL L+ L +N I
Sbjct: 559 LRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIG 618
Query: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGR 209
+ F+ L+ +++L L DN I ++ P F L +L + L
Sbjct: 619 CVSNDTFAGLSSVRLLSLYDNRITTITPGAF------------TTLVSLSTINLL----- 661
Query: 210 ILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPT 269
N + CNC L L WL + + G+ C P F K
Sbjct: 662 -------SNPFNCNCHLAWLGKWLRKR--RIVSGNPRCQKPFFLK--------------- 697
Query: 270 PPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYC 329
E P + +I D S +L + P
Sbjct: 698 -------EIPIQDV------AIQDFTCDGNEESSCQLSPRCPE----------------- 727
Query: 330 PIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTL 389
C C ++ C + + +L R P++ +L L GN + ++ + +L L
Sbjct: 728 --QCTC-----METVVRCSNKGLRALP--RGMPKDVTELYLEGNHLTAVPR-ELSALRHL 777
Query: 390 EMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKE 449
++ L NN I +L +F N++ L L L+ N L + F GL +L L L N I
Sbjct: 778 TLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISS 837
Query: 450 ILPGTFNPMPKLKVLYLNNNLL 471
+ G+FN + L L L N L
Sbjct: 838 VPEGSFNDLTSLSHLALGTNPL 859
Score = 91.7 bits (226), Expect = 3e-18
Identities = 73/270 (27%), Positives = 120/270 (44%), Gaps = 13/270 (4%)
Query: 325 PGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLV 384
P CP C C S + C + ++ R P+N +L L N I + K D
Sbjct: 30 PAVACPTKCTCSAAS-----VDCHGLGLRAVP--RGIPRNAERLDLDRNNITRITKMDFA 82
Query: 385 EYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEY 444
L +LHL +N++ V+E G+F +L +L++L LN N L L + +F L L L
Sbjct: 83 GLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSE 142
Query: 445 NAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNIL 503
N I+ I F + +K L L+NN + + F + L + L N + + V++
Sbjct: 143 NQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTS-F 201
Query: 504 DDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKAL-NS 562
+ + + + L N C C L L W+++ + TV LC +P HL + +
Sbjct: 202 NHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQ--RRTVGQFTLCMAPVHLRGFNVADVQKK 259
Query: 563 EILCPGLVNNPSMPTQTSYLMVTTPATTTN 592
E +CP + P S + +P T +N
Sbjct: 260 EYVCPAPHSEPPSCNANS-ISCPSPCTCSN 288
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 3/120 (2%)
Query: 116 QLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESL 175
+L++ N L + + L +L + NN I+++ FS ++ L LIL+ N + +
Sbjct: 756 ELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCI 814
Query: 176 PPNIFRFV-PLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLE 234
P + F + L L L GN + ++P G + + L L N C+C L L W++
Sbjct: 815 PVHAFNGLRSLRVLTLHGNDISSVPE-GSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK 873
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 150 bits (378), Expect = 6e-36
Identities = 138/535 (25%), Positives = 214/535 (40%), Gaps = 85/535 (15%)
Query: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTN 89
+C +LC C GT ++C G++ + + P +L L N +T +H NDF+GL
Sbjct: 33 ACPALCTCT---GTT-VDCHGTGLQAIPKNI--PRNTERLELNGNNITRIHKNDFAGLKQ 86
Query: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
+ L N I +E GAF+ + L++L +N N L +L E F + L L N I
Sbjct: 87 LRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQ 146
Query: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQTLPYVGFLEHIG 208
I AF LK L L+ N I + FR + L L L N + T+P F H+
Sbjct: 147 AIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF-NHMP 205
Query: 209 RILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICP 268
++ +L N C+C L L WL P + C+ P +G ++ ++K
Sbjct: 206 KLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLNVAEVQKSEF-- 261
Query: 269 TPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPY 328
+ S ++ G +P T L
Sbjct: 262 ------------------SCSGQGEA-----------------GRVPTCT-----LSSGS 281
Query: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
CP C C S ++ C+ + + ++ P +L L G I S+ Y
Sbjct: 282 CPAMCTC-----SNGIVDCRGKGLTAIPANLPETMTEIRLELNG--IKSIPPGAFSPYRK 334
Query: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
L + L NN+I + +F L L L L GN +T L +G+F GL+ L+ L L N I
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDL 508
I P F + L +L L +N +Q L F+ +L+ Q H
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFT-------SLRAIQTLH------------ 435
Query: 509 LTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSE 563
L NP+ C C+L L +++ + T C SP L K + + S+
Sbjct: 436 -----LAQNPFICDCNLKWLADFLR--TNPIETSGARCASPRRLANKRIGQIKSK 483
Score = 132 bits (333), Expect = 1e-30
Identities = 142/596 (23%), Positives = 227/596 (38%), Gaps = 113/596 (18%)
Query: 27 SRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSG 86
S GSC ++C C +++C KG+ + + P ++ L NG+ + FS
Sbjct: 278 SSGSCPAMCTCSNG----IVDCRGKGLTAIP--ANLPETMTEIRLELNGIKSIPPGAFSP 331
Query: 87 LTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
I L N IA+I AF GL L L + N + L F GL L+ L + N
Sbjct: 332 YRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNAN 391
Query: 147 FITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEH 206
I I P AF L L +L L DN I+SL F
Sbjct: 392 KINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTF------------------------TS 427
Query: 207 IGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESI 266
+ I L L N + C+C+L L +L P ++ C SP + ++K +
Sbjct: 428 LRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET--SGARCASPRRLANKRIGQIKSKKF 485
Query: 267 CPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPG 326
R S K + PG Y
Sbjct: 486 ----------------------------RCSAKEQYFI------PGTEDYQLNSECN-SD 510
Query: 327 PYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEY 386
CP C C+ ++ C + + + PQ+ +L L N I L + + +
Sbjct: 511 VVCPHKCRCE-----ANVVECSSLKLTKIPE--RIPQSTAELRLNNNEISILEATGMFKK 563
Query: 387 FT-LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYN 445
T L+ ++L NN++ +E+G+F + +L+L N L + GMF GL L L L N
Sbjct: 564 LTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623
Query: 446 AIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDD 505
I I +F + +++L L +N + + P F D
Sbjct: 624 RISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAF------------------------DT 659
Query: 506 LDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALN-SEI 564
L L+ ++L NP++C+C L L W++K + VT + C +P L + L+ + +
Sbjct: 660 LQSLSTLNLLANPFNCNCQLAWLGGWLRK--RKIVTGNPRCQNPDFLRQIPLQDVAFPDF 717
Query: 565 LCP------GLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGL 614
C G + P P + + L T ++ LR+L +P +V L L
Sbjct: 718 RCEEGQEEGGCLPRPQCPQECACL-----DTVVRCSNKHLRALPKGIPKNVTELYL 768
Score = 122 bits (307), Expect = 1e-27
Identities = 115/442 (26%), Positives = 182/442 (41%), Gaps = 87/442 (19%)
Query: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH-TNDFSGLTN 89
C C CE ++ C + + + E +P S +L L NN +++L T F LT+
Sbjct: 513 CPHKCRCEAN----VVECSSLKLTKIPE-RIPQSTA-ELRLNNNEISILEATGMFKKLTH 566
Query: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
I+L N +++IE GAF G + +LH+ N LE ++ F GL+ L L NN I+
Sbjct: 567 LKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRIS 626
Query: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGR 209
I +F+ L +++L L DN I ++ P F + LQ+L
Sbjct: 627 CIHNDSFTGLRNVRLLSLYDNQITTVSPGAF------------DTLQSLS---------- 664
Query: 210 ILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPT 269
L L N + CNC L L WL + + G+ C +P F L ++ + +
Sbjct: 665 --TLNLLANPFNCNCQLAWLGGWLRKR--KIVTGNPRCQNPDF-----LRQIPLQDVAFP 715
Query: 270 PPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYC 329
EE ++ G LP P C
Sbjct: 716 DFRCEEGQEEGGC-----------------------------------------LPRPQC 734
Query: 330 PIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTL 389
P C C ++ C +++ +L + P+N +L L GN +L+ L + L
Sbjct: 735 PQECAC-----LDTVVRCSNKHLRALP--KGIPKNVTELYLDGNQF-TLVPGQLSTFKYL 786
Query: 390 EMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKE 449
+++ L NN+I L SF N+++L L L+ N L + F GL +L L L N I
Sbjct: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST 846
Query: 450 ILPGTFNPMPKLKVLYLNNNLL 471
+ G F + L L + N L
Sbjct: 847 LQEGIFADVTSLSHLAIGANPL 868
Score = 87.4 bits (215), Expect = 5e-17
Identities = 72/253 (28%), Positives = 112/253 (44%), Gaps = 12/253 (4%)
Query: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
CP C C +G + C ++++ + P+N +L L GN I + K+D
Sbjct: 34 CPALCTC-----TGTTVDCHGTGLQAIP--KNIPRNTERLELNGNNITRIHKNDFAGLKQ 86
Query: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
L +L L N+I +E G+F ++ L++L LN N L L + +F L L L NAI+
Sbjct: 87 LRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQ 146
Query: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNILDDLD 507
I F LK L L+ N + + F + L + L N T +PVS+ + +
Sbjct: 147 AIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS-FNHMP 205
Query: 508 LLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKEL-KALNSEILC 566
L L N C C L L QW+++ + T+ C+ P L + + SE C
Sbjct: 206 KLRTFRLHSNHLFCDCHLAWLSQWLRQ--RPTIGLFTQCSGPASLRGLNVAEVQKSEFSC 263
Query: 567 PGLVNNPSMPTQT 579
G +PT T
Sbjct: 264 SGQGEAGRVPTCT 276
Score = 54.7 bits (130), Expect = 4e-07
Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 5/136 (3%)
Query: 138 LEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQ 196
L+ + NN I+ + S+F+ +++L LIL+ NA++ +PP F+ + L L L GN +
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 197 TLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGS 256
TL G + + L + N C+C L L +W++ + G C P +G
Sbjct: 846 TL-QEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEP--GIARCAGPQDMEGK 902
Query: 257 -ILSRLKKESICPTPP 271
+L+ K+ C PP
Sbjct: 903 LLLTTPAKKFECQGPP 918
Score = 39.7 bits (91), Expect = 0.012
Identities = 31/145 (21%), Positives = 60/145 (41%), Gaps = 7/145 (4%)
Query: 28 RGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGL 87
R C C C + ++ C K ++ + + P +L L N T++ S
Sbjct: 731 RPQCPQECACLDT----VVRCSNKHLRALPKGI--PKNVTELYLDGNQFTLV-PGQLSTF 783
Query: 88 TNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNF 147
+ L N I+ + +F + L L +++N+L+ + F GL +L L N
Sbjct: 784 KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGND 843
Query: 148 ITVIEPSAFSKLNRLKVLILNDNAI 172
I+ ++ F+ + L L + N +
Sbjct: 844 ISTLQEGIFADVTSLSHLAIGANPL 868
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 132 bits (333), Expect = 1e-30
Identities = 135/539 (25%), Positives = 205/539 (38%), Gaps = 96/539 (17%)
Query: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVP---PSRPFQLSLLNNGLTMLHTNDFSG 86
+C + C+C ++C ++ SVP P +L L N +T + DF+G
Sbjct: 27 ACPAQCSCSGST----VDCHGLALR-----SVPRNIPRNTERLDLNGNNITRITKTDFAG 77
Query: 87 LTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
L + + L N I+ IE GAF L L++L +N N L++ E F G L L N
Sbjct: 78 LRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSEN 137
Query: 147 FITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQTLPYVGFLE 205
I I AF +K L L+ N I + FR + L L L N + L F
Sbjct: 138 QIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF-N 196
Query: 206 HIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRL-KKE 264
H+ ++ +L N C+C L L WL P + C P +G ++ + K+E
Sbjct: 197 HMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQ--CMGPSHLRGHNVAEVQKRE 254
Query: 265 SICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQL 324
+C SG A S S+L
Sbjct: 255 FVC------------SGHQSFMAPSC-----------SVL-------------------- 271
Query: 325 PGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLV 384
+CP C C S ++ C+ + + + P + ++ L N I +
Sbjct: 272 ---HCPAACTC-----SNNIVDCRGKGLTEIPTNLP--ETITEIRLEQNTIKVIPPGAFS 321
Query: 385 EYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEY 444
Y L + L NN+I L +F L L L L GN +T+L K +F GL +L+ L L
Sbjct: 322 PYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNA 381
Query: 445 NAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILD 504
N I + F + L +L L +N LQ + FS
Sbjct: 382 NKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFS------------------------ 417
Query: 505 DLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSE 563
L + + L NP+ C C L L ++ + T CTSP L K + + S+
Sbjct: 418 PLRAIQTMHLAQNPFICDCHLKWLADYLH--TNPIETSGARCTSPRRLANKRIGQIKSK 474
Score = 117 bits (292), Expect = 6e-26
Identities = 134/545 (24%), Positives = 217/545 (39%), Gaps = 78/545 (14%)
Query: 75 GLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHG 134
GLT + TN +T I L N I I GAF+ L+++ +++N + L D F G
Sbjct: 290 GLTEIPTNLPETITE---IRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQG 346
Query: 135 LENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGN 193
L +L L N IT + S F L L++L+LN N I L + F+ + L L L N
Sbjct: 347 LRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDN 406
Query: 194 QLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFF 253
+LQT+ G + I + L N + C+C L L +L P ++ C SP
Sbjct: 407 KLQTIAK-GTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET--SGARCTSPRRL 463
Query: 254 KGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGL 313
+ ++K + R S K + PG
Sbjct: 464 ANKRIGQIKSKKF----------------------------RCSAKEQYFI------PGT 489
Query: 314 IPYITKPSTQLPGPY-CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAG 372
Y +K S CP C C+ G + C + + + + PQ +L L
Sbjct: 490 EDYRSKLSGDCFADLACPEKCRCE-----GTTVDCSNQKLNKIPE--HIPQYTAELRLNN 542
Query: 373 NIIHSLMKSDLVEYFT-LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMF 431
N L + + + L ++ NN+I +EEG+F + + ++ L N L + MF
Sbjct: 543 NEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMF 602
Query: 432 LGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKT 491
GL +L+ L L N I + +F + +++L L +N + + P F
Sbjct: 603 KGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAF------------ 650
Query: 492 NQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGH 551
D L L+ ++L NP++C+C L L +W++K K VT + C P
Sbjct: 651 ------------DTLHSLSTLNLLANPFNCNCYLAWLGEWLRK--KRIVTGNPRCQKPYF 696
Query: 552 LDKKELK--ALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSV 609
L + ++ A+ G +N P T T ++ L+ L +P V
Sbjct: 697 LKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDV 756
Query: 610 LILGL 614
L L
Sbjct: 757 TELYL 761
Score = 111 bits (278), Expect = 2e-24
Identities = 127/544 (23%), Positives = 207/544 (38%), Gaps = 138/544 (25%)
Query: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH-TNDFSGLT 88
+C C CE GT ++C + + + E P +L L NN T+L T F L
Sbjct: 505 ACPEKCRCE---GTT-VDCSNQKLNKIPEHI--PQYTAELRLNNNEFTVLEATGIFKKLP 558
Query: 89 NAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFI 148
I+ N I DIE GAF G + ++ + N LE ++ F GLE+L+ L +N I
Sbjct: 559 QLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRI 618
Query: 149 TVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIG 208
T + +F L+ +++L L DN I ++ P F + +
Sbjct: 619 TCVGNDSFIGLSSVRLLSLYDNQITTVAPGAF------------------------DTLH 654
Query: 209 RILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICP 268
+ L L N + CNC L L WL + + G+ C P F K + + +
Sbjct: 655 SLSTLNLLANPFNCNCYLAWLGEWLRK--KRIVTGNPRCQKPYFLKEIPIQDVAIQDF-- 710
Query: 269 TPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPY 328
+ +D + + + PT+
Sbjct: 711 ---------------------TCDDGNDDNSCSPLSRCPTE------------------- 730
Query: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
C C ++ C + ++ L + P++ +L L GN +L+ +L Y
Sbjct: 731 ----CTC-----LDTVVRCSNKGLKVLP--KGIPRDVTELYLDGNQF-TLVPKELSNYKH 778
Query: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
L ++ L NNRI L SF N+T+L LT L L YN ++
Sbjct: 779 LTLIDLSNNRISTLSNQSFSNMTQL---------LT---------------LILSYNRLR 814
Query: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDL 508
I P TF+ + L++L L+ N + V+P F +DL
Sbjct: 815 CIPPRTFDGLKSLRLLSLHGNDISVVPEGAF------------------------NDLSA 850
Query: 509 LTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHL-DKKELKALNSEILCP 567
L+ + + NP C C++ L W++ S+ C PG + DK L + + C
Sbjct: 851 LSHLAIGANPLYCDCNMQWLSDWVK--SEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ 908
Query: 568 GLVN 571
G V+
Sbjct: 909 GPVD 912
Score = 90.1 bits (222), Expect = 8e-18
Identities = 70/242 (28%), Positives = 106/242 (43%), Gaps = 12/242 (4%)
Query: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
CP C+C SG + C + S+ R P+N +L L GN I + K+D
Sbjct: 28 CPAQCSC-----SGSTVDCHGLALRSVP--RNIPRNTERLDLNGNNITRITKTDFAGLRH 80
Query: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
L +L L N+I +E G+F +L L++L LN NHL + +FLG L L L N I+
Sbjct: 81 LRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQ 140
Query: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNILDDLD 507
I F +K L L+ N + + F + L + L N T L V++ + +
Sbjct: 141 AIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVAS-FNHMP 199
Query: 508 LLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNS-EILC 566
L L N C C L L W+++ + + C P HL + + E +C
Sbjct: 200 KLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQ--CMGPSHLRGHNVAEVQKREFVC 257
Query: 567 PG 568
G
Sbjct: 258 SG 259
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 127 bits (319), Expect = 4e-29
Identities = 141/531 (26%), Positives = 211/531 (39%), Gaps = 74/531 (13%)
Query: 69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILK 128
L+L +N L L F GL + L N ++ + A GL L++L ++HN L+ L
Sbjct: 163 LNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALP 222
Query: 129 EDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTH- 187
L L+ +N +T L L+ L+L+ A+++L P F P H
Sbjct: 223 GPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHT 282
Query: 188 LDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC 247
LDLRGNQL TLP L+ G++ L+L+ N C C L WL +S D C
Sbjct: 283 LDLRGNQLDTLPP---LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRS---DGAC 336
Query: 248 NSPPFFKGSILSRLKKESI-CPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKL 306
P +G L L+ + CP EE E + + + +
Sbjct: 337 QGPRRLRGEALDALRPWDLRCPGDAAQEEEE------------------LEERAVAGPRA 378
Query: 307 PTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPR 366
P + P P + CP C C P C+ ++++ R P + +
Sbjct: 379 PPRGPP-----RGPGEERAVAPCPRACVCV---PESRHSSCEGCGLQAVP--RGFPSDTQ 428
Query: 367 KLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKL 426
L L N S+ ++ L LHL + I LE G+ L RL LYL+ N L L
Sbjct: 429 LLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGL 488
Query: 427 SKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPH--------- 477
S G L YLYLE N ++ +P L L+L +N + L P
Sbjct: 489 SAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALR 548
Query: 478 --IFSGVPLT--------------KVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDC 521
SG +T K++L NQ +P + L+ L L ++ L NP
Sbjct: 549 WVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP-TGALEGLPALLELQLSGNPLRA 607
Query: 522 SCD--LVGLQQWIQKLSKNTVTDDILC------TSPG----HLDKKELKAL 560
D + + +Q L N+ + +C PG HL K +L+AL
Sbjct: 608 LRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRAL 658
Score = 85.9 bits (211), Expect = 1e-16
Identities = 66/217 (30%), Positives = 103/217 (47%), Gaps = 10/217 (4%)
Query: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
L L N + L DL L ++L NRI + G+ L+KL+L+ N L ++
Sbjct: 526 LHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585
Query: 428 KGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPK-LKVLYLNNNLLQVLPPHIFSGVP--L 484
G GL L L L N ++ + G F P+ + L+ L+LN++ L+ + P FSG+ L
Sbjct: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGL 645
Query: 485 TKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDI 544
++L+ NQ LP L L+L IDL NP+ C C L+ L +W+ L+
Sbjct: 646 QSLHLQKNQLRALPALPSLSQLEL---IDLSSNPFHCDCQLLPLHRWLTGLNLRV---GA 699
Query: 545 LCTSPGHLDKKELKALNSEIL-CPGLVNNPSMPTQTS 580
C +P + + +KA + CPG + T S
Sbjct: 700 TCATPPNARGQRVKAAAAVFEDCPGWAARKAKRTPAS 736
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/177 (31%), Positives = 86/177 (48%), Gaps = 5/177 (2%)
Query: 306 LPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNP 365
+P P L+ + P+ Q CP C C S + C+ +N+ + D P +
Sbjct: 10 VPLVLPLLVLLLLAPARQAAAQRCPQACIC---DNSRRHVACRYQNLTEVPDAIP--ELT 64
Query: 366 RKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTK 425
++L L GN++ + + L L L + +E++ EG+F L RL L L NHL +
Sbjct: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124
Query: 426 LSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV 482
L + GL +L L LE NA++E+ PGTF + L L L +N L LP F G+
Sbjct: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGL 181
Score = 75.1 bits (183), Expect = 3e-13
Identities = 58/193 (30%), Positives = 90/193 (46%), Gaps = 11/193 (5%)
Query: 67 FQLSLLNNGLTMLHTNDFSGLTNAIS-IHLGFNNIADIEIGAFNGLGLLKQLHINHNSLE 125
F L L +N + L D G T A+ ++L N I ++ +GA L++LH++ N L
Sbjct: 524 FSLHLQDNAVDRLAPGDL-GRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLR 582
Query: 126 ILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNR-LKVLILNDNAIESLPPNIFRFV- 183
+ GL L LQ N + + AF + R L+ L LN + +E + P F +
Sbjct: 583 EVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLG 642
Query: 184 -PLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSII 242
L L L+ NQL+ LP + L + I L N + C+C LL L WL + ++
Sbjct: 643 PGLQSLHLQKNQLRALPALPSLSQLELI---DLSSNPFHCDCQLLPLHRWLTGL---NLR 696
Query: 243 GDVVCNSPPFFKG 255
C +PP +G
Sbjct: 697 VGATCATPPNARG 709
Score = 67.8 bits (164), Expect = 4e-11
Identities = 67/230 (29%), Positives = 97/230 (42%), Gaps = 34/230 (14%)
Query: 366 RKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTK 425
R+L L GN + L L L+L +N + L +F L R++ L L+ N L+
Sbjct: 137 RRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSV 196
Query: 426 LSKGMFLGLHNLEYLYLEYNAIKEILPGT--------------FNP-----------MPK 460
L+ GL L L L +N + + LPG NP +P
Sbjct: 197 LAPEALAGLPALRRLSLHHNEL-QALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPG 255
Query: 461 LKVLYLNNNLLQVLPPHIFSGVP-LTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPW 519
L+ L L+ LQ L P F+ P L ++L+ NQ LP L L ++ L+ NP
Sbjct: 256 LRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP---LQGPGQLRRLRLQGNPL 312
Query: 520 DCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNS-EILCPG 568
C C L +W L++ V D C P L + L AL ++ CPG
Sbjct: 313 WCGCQARPLLEW---LARARVRSDGACQGPRRLRGEALDALRPWDLRCPG 359
Score = 63.9 bits (154), Expect = 6e-10
Identities = 62/213 (29%), Positives = 87/213 (40%), Gaps = 30/213 (14%)
Query: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNA 90
C C C + +CE G++ V PS L L N + F GL +
Sbjct: 396 CPRACVCVPESRHS--SCEGCGLQAVPRGF--PSDTQLLDLRRNHFPSVPRAAFPGLGHL 451
Query: 91 ISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITV 150
+S+HL IA++E GA GLG L L+++ N L L G L +L + N
Sbjct: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQ 511
Query: 151 IEPSAFSKLNRLKVLILNDNAIESLPP------NIFRFV-------------------PL 185
+ +A L L L L DNA++ L P R+V L
Sbjct: 512 VPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAREL 571
Query: 186 THLDLRGNQLQTLPYVGFLEHIGRILDLQLEDN 218
L L NQL+ +P G LE + +L+LQL N
Sbjct: 572 EKLHLDRNQLREVP-TGALEGLPALLELQLSGN 603
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 103 bits (256), Expect = 9e-22
Identities = 92/326 (28%), Positives = 138/326 (42%), Gaps = 66/326 (20%)
Query: 303 ILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPP 362
+L+ P A L+ + P L P CP+ C C P+ + CQ N S+ PP
Sbjct: 8 LLQAPASACLLLMLLALP---LAAPSCPMLCTCYSSPPT---VSCQANNFSSVPLSLPP- 60
Query: 363 QNPRKLILAGNIIHSLMK----SDLVEYF------------------TLEMLHLGNNR-I 399
+ ++L L N+I +L S+L+ + LE L LG+NR +
Sbjct: 61 -STQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHL 119
Query: 400 EVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMP 459
LE +F L RLQ L+L L+ L +F GL +L+YLYL+ N++ + F +
Sbjct: 120 RSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLA 179
Query: 460 KLKVLYLNNNLLQVLPPHIFSGV-------------------------PLTKVNLKTNQF 494
L L+L+ N L++L H+F G+ LT + L N
Sbjct: 180 NLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSL 239
Query: 495 THLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDK 554
LP L DL L + L NPW C C L W Q+ + D+ C +P
Sbjct: 240 ASLP-GEALADLPSLEFLRLNANPWACDCRARPLWAWFQR--ARVSSSDVTCATPPERQG 296
Query: 555 KELKALNSEIL--CPGLVNNPSMPTQ 578
++L+AL CP P+ PT+
Sbjct: 297 RDLRALREADFQACP-----PAAPTR 317
Score = 84.0 bits (206), Expect = 5e-16
Identities = 79/291 (27%), Positives = 119/291 (40%), Gaps = 57/291 (19%)
Query: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTN 89
SC LC C T ++C+A V +S+PPS +L L NN + L F +N
Sbjct: 30 SCPMLCTCYSSPPT--VSCQANNFSSVP-LSLPPSTQ-RLFLQNNLIRTLRPGTFG--SN 83
Query: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNS-LEILKEDTFHGLE------------ 136
+++ L NN++ I G F L L++L + N L L+ DTF GLE
Sbjct: 84 LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQL 143
Query: 137 ------------NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV- 183
+L++L N + ++ F+ L L L L+ N + L ++FR +
Sbjct: 144 SSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLG 203
Query: 184 PLTHLDLRGNQLQTLPYVGF-----------------------LEHIGRILDLQLEDNKW 220
L L L GN+LQ + F L + + L+L N W
Sbjct: 204 SLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPW 263
Query: 221 ACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPP 271
AC+C L W + S DV C +PP +G L L++ PP
Sbjct: 264 ACDCRARPLWAWFQRARVSS--SDVTCATPPERQGRDLRALREADFQACPP 312
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 102 bits (255), Expect = 1e-21
Identities = 81/262 (30%), Positives = 120/262 (45%), Gaps = 37/262 (14%)
Query: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTN 89
SC C C+ T ++C +G+ + P +R
Sbjct: 20 SCPDKCYCQSS--TNFVDCSQQGLAEIPSHLPPQTR------------------------ 53
Query: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
++HL N I + AF + L L++++NSL L FHGL++L+ L N +
Sbjct: 54 --TLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLL 111
Query: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIFR-FVPLTHLDLRGNQLQTLPYVGFLEHIG 208
+E F L +L+ L L+ N I LP ++ + LT L ++ NQLQ L LE +
Sbjct: 112 SLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDR-ALLESMP 170
Query: 209 RILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGD-VVCNSPPFFKGSILSRLKKE--S 265
+ L L+DN W CNC LL LK WLE + + D ++C SP +KG L R+ E
Sbjct: 171 SVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQ 230
Query: 266 ICPTP---PVYEEHEDPSGSLH 284
CP P PV + + P GS H
Sbjct: 231 PCPLPAPDPVSSQAQWP-GSAH 251
Score = 89.0 bits (219), Expect = 2e-17
Identities = 57/178 (32%), Positives = 100/178 (56%), Gaps = 3/178 (1%)
Query: 392 LHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEIL 451
LHL +N+I L +F ++ L L L+ N L+ L+ G F GL +L+ L L N++ +
Sbjct: 55 LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
Query: 452 PGTFNPMPKLKVLYLNNNLLQVLPPHI-FSGVPLTKVNLKTNQFTHLPVSNILDDLDLLT 510
F+ +P+L+ L L++N + LP + + LT + ++ NQ L + +L+ + +
Sbjct: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA-LLESMPSVR 173
Query: 511 QIDLEDNPWDCSCDLVGLQQWIQK-LSKNTVTDDILCTSPGHLDKKELKALNSEILCP 567
+ L+DN W C+C L+GL+ W++K + K +TD I+C SP K+L + E+ P
Sbjct: 174 LLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 102 bits (253), Expect = 2e-21
Identities = 80/280 (28%), Positives = 125/280 (44%), Gaps = 36/280 (12%)
Query: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423
N ++L L+ N I L S ++ L L L N ++ L G F + L++L+L NH+
Sbjct: 252 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHI 311
Query: 424 TKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLN---------------- 467
+ L +F L L+ L L N I I PG FN + +L+ L L+
Sbjct: 312 SSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLA 371
Query: 468 --------NNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNP 518
NN L+ LP +IF+ V L + L+ NQ +LP+ I D L L ++ L DNP
Sbjct: 372 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL-GIFDHLGKLCELRLYDNP 430
Query: 519 WDCSCDLVGLQQWIQKLSKNTVTDDI-LCTSPGHLDKKELKALNSEILCPGL-------- 569
W C D++ L+ W+ TD + +C SP ++ + L +N + P +
Sbjct: 431 WRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSY 490
Query: 570 VNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSV 609
P P SY T+ ++TT + TD + V
Sbjct: 491 PETPWYPDTPSYPDTTSVSSTTELTSPV-EDYTDLTTIQV 529
Score = 99.4 bits (246), Expect = 1e-20
Identities = 73/262 (27%), Positives = 119/262 (45%), Gaps = 28/262 (10%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEIL 127
+L L NN ++ L + F L + L N++ ++ +G F + L++L + N + L
Sbjct: 255 RLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 314
Query: 128 KEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP--- 184
++ F L L+ L N I+ I P AF+ L L+ L L+ NA++ L N+FR +
Sbjct: 315 PDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 374
Query: 185 ----------------------LTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWAC 222
L + L+ NQL+ LP +G +H+G++ +L+L DN W C
Sbjct: 375 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP-LGIFDHLGKLCELRLYDNPWRC 433
Query: 223 NCDLLQLKTW-LENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSG 281
+ D+L L+ W L N P VC SP +G L + P+ V E P
Sbjct: 434 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPET 493
Query: 282 SLHLAATSSINDSRMSTKTTSI 303
+ T S D+ + TT +
Sbjct: 494 PWY-PDTPSYPDTTSVSSTTEL 514
Score = 89.0 bits (219), Expect = 2e-17
Identities = 60/191 (31%), Positives = 99/191 (51%), Gaps = 9/191 (4%)
Query: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNA 90
C S C C E G ++V+ + P L +LN +T L+ + F ++
Sbjct: 31 CPSECTCSRAS-----QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 85
Query: 91 ISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITV 150
I++ + N ++ I GAF LG L+ L + +N L++L F GL++LE L +N +
Sbjct: 86 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 145
Query: 151 IEPSAFSKLNRLKVLILNDNAIESLPPNIF-RFVPLTHLDLRGNQLQTL-PYVGFLEHIG 208
I+P+ FS+ + LK L L+ N +E +P F V LT L+L N L + P V +H+G
Sbjct: 146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV--FQHLG 203
Query: 209 RILDLQLEDNK 219
+ L+L +N+
Sbjct: 204 NLQVLRLYENR 214
Score = 80.5 bits (197), Expect = 6e-15
Identities = 74/249 (29%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
CP C C S + C I ++ P P N L + I L +S +
Sbjct: 31 CPSECTCSRASQ----VECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNISA 84
Query: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
L L + N + + G+F NL L+ L L N L L G+F GL +LE L L N +
Sbjct: 85 LIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 144
Query: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSG-VPLTKVNLKTNQFTHLP--VSNILDD 505
+I P F+ LK L L+ N L+ +P F V LTK+NL N TH+ V L +
Sbjct: 145 QIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN 204
Query: 506 LDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEI- 564
L +L +L +N +TD + T G ++ +EL ++I
Sbjct: 205 LQVL------------------------RLYENRLTDIPMGTFDGLVNLQELALQQNQIG 240
Query: 565 -LCPGLVNN 572
L PGL +N
Sbjct: 241 LLSPGLFHN 249
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/152 (33%), Positives = 74/152 (48%), Gaps = 2/152 (1%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEIL 127
+L L N L + F L ++LG N++ I F LG L+ L + N L +
Sbjct: 159 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218
Query: 128 KEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LT 186
TF GL NL+ L N I ++ P F + L+ L L++N I LPP+IF +P L
Sbjct: 219 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 278
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDN 218
L L GN L+ L +G + + +L L DN
Sbjct: 279 RLTLFGNSLKELS-LGIFGPMPNLRELWLYDN 309
Score = 70.9 bits (172), Expect = 5e-12
Identities = 53/155 (34%), Positives = 76/155 (49%), Gaps = 2/155 (1%)
Query: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423
N ++L L GN + + L L+LG N + + F +L LQ L L N L
Sbjct: 156 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215
Query: 424 TKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVP 483
T + G F GL NL+ L L+ N I + PG F+ L+ LYL+NN + LPP IF +P
Sbjct: 216 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 275
Query: 484 -LTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDN 517
L ++ L N L + I + L ++ L DN
Sbjct: 276 QLNRLTLFGNSLKELSL-GIFGPMPNLRELWLYDN 309
Score = 70.5 bits (171), Expect = 6e-12
Identities = 46/133 (34%), Positives = 69/133 (51%), Gaps = 1/133 (0%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEIL 127
+L+L N LT + F L N + L N + DI +G F+GL L++L + N + +L
Sbjct: 183 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 242
Query: 128 KEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LT 186
FH NL+ L NN I+ + PS F +L +L L L N+++ L IF +P L
Sbjct: 243 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 302
Query: 187 HLDLRGNQLQTLP 199
L L N + +LP
Sbjct: 303 ELWLYDNHISSLP 315
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/151 (31%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
L+L+ N + + + + L+ L L N +E + +G+F +L L KL L N LT +S
Sbjct: 136 LLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS 195
Query: 428 KGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIF-SGVPLTK 486
+F L NL+ L L N + +I GTF+ + L+ L L N + +L P +F + L +
Sbjct: 196 PRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQR 255
Query: 487 VNLKTNQFTHLPVSNILDDLDLLTQIDLEDN 517
+ L N + LP S I L L ++ L N
Sbjct: 256 LYLSNNHISQLPPS-IFMQLPQLNRLTLFGN 285
Score = 65.9 bits (159), Expect = 2e-10
Identities = 96/388 (24%), Positives = 144/388 (37%), Gaps = 64/388 (16%)
Query: 69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILK 128
LSL NN L +L F GL + S+ L N + I+ F+ LK+L ++ N LE +
Sbjct: 112 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171
Query: 129 EDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF-RFVPLTH 187
+ F L L L N +T I P F L L+VL L +N + +P F V L
Sbjct: 172 DGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQE 231
Query: 188 LDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC 247
L L+ NQ+ L G + + L L +N + +PP +
Sbjct: 232 LALQQNQIGLLS-PGLFHNNHNLQRLYLSNNH-------------ISQLPPSIFMQLPQL 277
Query: 248 NSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLP 307
N F G+ L L P P + E + D+ +S+ ++
Sbjct: 278 NRLTLF-GNSLKELSLGIFGPMPNLRE--------------LWLYDNHISSLPDNVFSNL 322
Query: 308 TKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRK 367
+ LI + S PG + L++LR +
Sbjct: 323 RQLQVLILSRNQISFISPGAF------------------------NGLTELR-------E 351
Query: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
L L N + L + L+ + L NNR+ L F N+ L + L N L L
Sbjct: 352 LSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 411
Query: 428 KGMFLGLHNLEYLYLEYNAIK---EILP 452
G+F L L L L N + +ILP
Sbjct: 412 LGIFDHLGKLCELRLYDNPWRCDSDILP 439
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 102 bits (253), Expect = 2e-21
Identities = 80/280 (28%), Positives = 125/280 (44%), Gaps = 36/280 (12%)
Query: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423
N ++L L+ N I L S ++ L L L N ++ L G F + L++L+L NH+
Sbjct: 246 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHI 305
Query: 424 TKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLN---------------- 467
+ L +F L L+ L L N I I PG FN + +L+ L L+
Sbjct: 306 SSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLA 365
Query: 468 --------NNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNP 518
NN L+ LP +IF+ V L + L+ NQ +LP+ I D L L ++ L DNP
Sbjct: 366 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL-GIFDHLGKLCELRLYDNP 424
Query: 519 WDCSCDLVGLQQWIQKLSKNTVTDDI-LCTSPGHLDKKELKALNSEILCPGL-------- 569
W C D++ L+ W+ TD + +C SP ++ + L +N + P +
Sbjct: 425 WRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSY 484
Query: 570 VNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSV 609
P P SY T+ ++TT + TD + V
Sbjct: 485 PETPWYPDTPSYPDTTSVSSTTELTSPV-EDYTDLTTIQV 523
Score = 99.4 bits (246), Expect = 1e-20
Identities = 73/262 (27%), Positives = 119/262 (45%), Gaps = 28/262 (10%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEIL 127
+L L NN ++ L + F L + L N++ ++ +G F + L++L + N + L
Sbjct: 249 RLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 308
Query: 128 KEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP--- 184
++ F L L+ L N I+ I P AF+ L L+ L L+ NA++ L N+FR +
Sbjct: 309 PDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 368
Query: 185 ----------------------LTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWAC 222
L + L+ NQL+ LP +G +H+G++ +L+L DN W C
Sbjct: 369 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP-LGIFDHLGKLCELRLYDNPWRC 427
Query: 223 NCDLLQLKTW-LENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSG 281
+ D+L L+ W L N P VC SP +G L + P+ V E P
Sbjct: 428 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPET 487
Query: 282 SLHLAATSSINDSRMSTKTTSI 303
+ T S D+ + TT +
Sbjct: 488 PWY-PDTPSYPDTTSVSSTTEL 508
Score = 89.0 bits (219), Expect = 2e-17
Identities = 60/191 (31%), Positives = 99/191 (51%), Gaps = 9/191 (4%)
Query: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNA 90
C S C C E G ++V+ + P L +LN +T L+ + F ++
Sbjct: 25 CPSECTCSRAS-----QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
Query: 91 ISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITV 150
I++ + N ++ I GAF LG L+ L + +N L++L F GL++LE L +N +
Sbjct: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
Query: 151 IEPSAFSKLNRLKVLILNDNAIESLPPNIF-RFVPLTHLDLRGNQLQTL-PYVGFLEHIG 208
I+P+ FS+ + LK L L+ N +E +P F V LT L+L N L + P V +H+G
Sbjct: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV--FQHLG 197
Query: 209 RILDLQLEDNK 219
+ L+L +N+
Sbjct: 198 NLQVLRLYENR 208
Score = 80.5 bits (197), Expect = 6e-15
Identities = 74/249 (29%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFT 388
CP C C S + C I ++ P P N L + I L +S +
Sbjct: 25 CPSECTCSRASQ----VECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNISA 78
Query: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448
L L + N + + G+F NL L+ L L N L L G+F GL +LE L L N +
Sbjct: 79 LIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 138
Query: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSG-VPLTKVNLKTNQFTHLP--VSNILDD 505
+I P F+ LK L L+ N L+ +P F V LTK+NL N TH+ V L +
Sbjct: 139 QIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN 198
Query: 506 LDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEI- 564
L +L +L +N +TD + T G ++ +EL ++I
Sbjct: 199 LQVL------------------------RLYENRLTDIPMGTFDGLVNLQELALQQNQIG 234
Query: 565 -LCPGLVNN 572
L PGL +N
Sbjct: 235 LLSPGLFHN 243
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/152 (33%), Positives = 74/152 (48%), Gaps = 2/152 (1%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEIL 127
+L L N L + F L ++LG N++ I F LG L+ L + N L +
Sbjct: 153 ELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212
Query: 128 KEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LT 186
TF GL NL+ L N I ++ P F + L+ L L++N I LPP+IF +P L
Sbjct: 213 PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLN 272
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDN 218
L L GN L+ L +G + + +L L DN
Sbjct: 273 RLTLFGNSLKELS-LGIFGPMPNLRELWLYDN 303
Score = 70.9 bits (172), Expect = 5e-12
Identities = 53/155 (34%), Positives = 76/155 (49%), Gaps = 2/155 (1%)
Query: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423
N ++L L GN + + L L+LG N + + F +L LQ L L N L
Sbjct: 150 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209
Query: 424 TKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVP 483
T + G F GL NL+ L L+ N I + PG F+ L+ LYL+NN + LPP IF +P
Sbjct: 210 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 269
Query: 484 -LTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDN 517
L ++ L N L + I + L ++ L DN
Sbjct: 270 QLNRLTLFGNSLKELSL-GIFGPMPNLRELWLYDN 303
Score = 70.5 bits (171), Expect = 6e-12
Identities = 46/133 (34%), Positives = 69/133 (51%), Gaps = 1/133 (0%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEIL 127
+L+L N LT + F L N + L N + DI +G F+GL L++L + N + +L
Sbjct: 177 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 236
Query: 128 KEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LT 186
FH NL+ L NN I+ + PS F +L +L L L N+++ L IF +P L
Sbjct: 237 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLR 296
Query: 187 HLDLRGNQLQTLP 199
L L N + +LP
Sbjct: 297 ELWLYDNHISSLP 309
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/151 (31%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
L+L+ N + + + + L+ L L N +E + +G+F +L L KL L N LT +S
Sbjct: 130 LLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS 189
Query: 428 KGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIF-SGVPLTK 486
+F L NL+ L L N + +I GTF+ + L+ L L N + +L P +F + L +
Sbjct: 190 PRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQR 249
Query: 487 VNLKTNQFTHLPVSNILDDLDLLTQIDLEDN 517
+ L N + LP S I L L ++ L N
Sbjct: 250 LYLSNNHISQLPPS-IFMQLPQLNRLTLFGN 279
Score = 65.9 bits (159), Expect = 2e-10
Identities = 96/388 (24%), Positives = 144/388 (37%), Gaps = 64/388 (16%)
Query: 69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILK 128
LSL NN L +L F GL + S+ L N + I+ F+ LK+L ++ N LE +
Sbjct: 106 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 165
Query: 129 EDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF-RFVPLTH 187
+ F L L L N +T I P F L L+VL L +N + +P F V L
Sbjct: 166 DGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQE 225
Query: 188 LDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC 247
L L+ NQ+ L G + + L L +N + +PP +
Sbjct: 226 LALQQNQIGLLS-PGLFHNNHNLQRLYLSNNH-------------ISQLPPSIFMQLPQL 271
Query: 248 NSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLP 307
N F G+ L L P P + E + D+ +S+ ++
Sbjct: 272 NRLTLF-GNSLKELSLGIFGPMPNLRE--------------LWLYDNHISSLPDNVFSNL 316
Query: 308 TKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRK 367
+ LI + S PG + L++LR +
Sbjct: 317 RQLQVLILSRNQISFISPGAF------------------------NGLTELR-------E 345
Query: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
L L N + L + L+ + L NNR+ L F N+ L + L N L L
Sbjct: 346 LSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405
Query: 428 KGMFLGLHNLEYLYLEYNAIK---EILP 452
G+F L L L L N + +ILP
Sbjct: 406 LGIFDHLGKLCELRLYDNPWRCDSDILP 433
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 100 bits (248), Expect = 7e-21
Identities = 63/183 (34%), Positives = 98/183 (53%), Gaps = 12/183 (6%)
Query: 388 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKG--MFLGLHNLEYLYLEYN 445
T+E L L +NRI + S LT L++L L+GN L G +F L NL L L N
Sbjct: 176 TIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRN 235
Query: 446 AIKEI---LPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSN 501
++ LPGT L+ LYL +N + +PP+ FS + L ++++ N ++LP
Sbjct: 236 SLTAAPVNLPGT-----NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLP-QG 289
Query: 502 ILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALN 561
I DDLD +TQ+ L +NPW C C + ++ W+Q L ++C +P + +K LN
Sbjct: 290 IFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLN 349
Query: 562 SEI 564
+E+
Sbjct: 350 AEL 352
Score = 77.4 bits (189), Expect = 5e-14
Identities = 57/183 (31%), Positives = 86/183 (46%), Gaps = 7/183 (3%)
Query: 86 GLTNAIS-IHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI--LKEDTFHGLENLEFLQ 142
GL I + L N I+ I + GL LK+L ++ N L L + F L NL L
Sbjct: 172 GLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELS 231
Query: 143 ADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQTLPYV 201
N +T P N L+ L L DN I +PPN F ++ L LD+ N L LP
Sbjct: 232 LVRNSLTAA-PVNLPGTN-LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ- 288
Query: 202 GFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRL 261
G + + I L L +N W C C + ++ WL+++P + + ++C +P +G + L
Sbjct: 289 GIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDL 348
Query: 262 KKE 264
E
Sbjct: 349 NAE 351
Score = 47.0 bits (110), Expect = 7e-05
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 20/175 (11%)
Query: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVP---PSRPFQLSLLNNGLTMLHT-NDFS 85
SC S+C C+ I C + + S+P P L L NN + +D
Sbjct: 30 SCPSVCRCDAG----FIYCNDRFLT-----SIPTGIPEDATTLYLQNNQINNAGIPSDLK 80
Query: 86 GLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADN 145
L I+L N++ + N +K+LH+ N++ + D+ + LE L D+
Sbjct: 81 NLLKVERIYLYHNSLDEFPT---NLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDD 137
Query: 146 NFITV--IEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTL 198
N ++ IE AF N L++L L+ N + ++P + R + LD N++ T+
Sbjct: 138 NSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLD--DNRISTI 190
Score = 33.1 bits (74), Expect = 1.1
Identities = 60/280 (21%), Positives = 105/280 (37%), Gaps = 61/280 (21%)
Query: 153 PSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILD 212
PS L +++ + L N+++ P N+ ++V HL + N ++T+ Y L I + +
Sbjct: 76 PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHL--QENNIRTITYDS-LSKIPYLEE 132
Query: 213 LQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPV 272
L L+DN + I + + + LSR +I
Sbjct: 133 LHLDDNSVSAVS-----------------IEEGAFRDSNYLRLLFLSRNHLSTI------ 169
Query: 273 YEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIP 332
P G ++D+R+ST I+ PS Q +
Sbjct: 170 ------PWGLPRTIEELRLDDNRIST------------------ISSPSLQGLTSLKRLV 205
Query: 333 CNCKVLSPSGL-------LIHCQE----RNIESLSDLRPPPQNPRKLILAGNIIHSLMKS 381
+ +L+ GL L++ E RN + + + P N RKL L N I+ + +
Sbjct: 206 LDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPN 265
Query: 382 DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGN 421
L L + NN + L +G F +L + +L L N
Sbjct: 266 AFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Score = 30.0 bits (66), Expect = 9.3
Identities = 16/64 (25%), Positives = 34/64 (53%)
Query: 59 ISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLH 118
+++P + +L L +N + + N FS L + + NN++++ G F+ L + QL
Sbjct: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLI 301
Query: 119 INHN 122
+ +N
Sbjct: 302 LRNN 305
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 100 bits (248), Expect = 7e-21
Identities = 63/183 (34%), Positives = 98/183 (53%), Gaps = 12/183 (6%)
Query: 388 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKG--MFLGLHNLEYLYLEYN 445
T+E L L +NRI + S LT L++L L+GN L G +F L NL L L N
Sbjct: 176 TIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRN 235
Query: 446 AIKEI---LPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSN 501
++ LPGT L+ LYL +N + +PP+ FS + L ++++ N ++LP
Sbjct: 236 SLTAAPVNLPGT-----NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLP-QG 289
Query: 502 ILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALN 561
I DDLD +TQ+ L +NPW C C + ++ W+Q L ++C +P + +K LN
Sbjct: 290 IFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLN 349
Query: 562 SEI 564
+E+
Sbjct: 350 AEL 352
Score = 77.4 bits (189), Expect = 5e-14
Identities = 57/183 (31%), Positives = 86/183 (46%), Gaps = 7/183 (3%)
Query: 86 GLTNAIS-IHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEI--LKEDTFHGLENLEFLQ 142
GL I + L N I+ I + GL LK+L ++ N L L + F L NL L
Sbjct: 172 GLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELS 231
Query: 143 ADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTHLDLRGNQLQTLPYV 201
N +T P N L+ L L DN I +PPN F ++ L LD+ N L LP
Sbjct: 232 LVRNSLTAA-PVNLPGTN-LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ- 288
Query: 202 GFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRL 261
G + + I L L +N W C C + ++ WL+++P + + ++C +P +G + L
Sbjct: 289 GIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDL 348
Query: 262 KKE 264
E
Sbjct: 349 NAE 351
Score = 47.0 bits (110), Expect = 7e-05
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 20/175 (11%)
Query: 30 SCDSLCNCEEKDGTMLINCEAKGIKMVSEISVP---PSRPFQLSLLNNGLTMLHT-NDFS 85
SC S+C C+ I C + + S+P P L L NN + +D
Sbjct: 30 SCPSVCRCDAG----FIYCNDRFLT-----SIPTGIPEDATTLYLQNNQINNAGIPSDLK 80
Query: 86 GLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADN 145
L I+L N++ + N +K+LH+ N++ + D+ + LE L D+
Sbjct: 81 NLLKVERIYLYHNSLDEFPT---NLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDD 137
Query: 146 NFITV--IEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTL 198
N ++ IE AF N L++L L+ N + ++P + R + LD N++ T+
Sbjct: 138 NSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLD--DNRISTI 190
Score = 33.1 bits (74), Expect = 1.1
Identities = 60/280 (21%), Positives = 105/280 (37%), Gaps = 61/280 (21%)
Query: 153 PSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILD 212
PS L +++ + L N+++ P N+ ++V HL + N ++T+ Y L I + +
Sbjct: 76 PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHL--QENNIRTITYDS-LSKIPYLEE 132
Query: 213 LQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPV 272
L L+DN + I + + + LSR +I
Sbjct: 133 LHLDDNSVSAVS-----------------IEEGAFRDSNYLRLLFLSRNHLSTI------ 169
Query: 273 YEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIP 332
P G ++D+R+ST I+ PS Q +
Sbjct: 170 ------PWGLPRTIEELRLDDNRIST------------------ISSPSLQGLTSLKRLV 205
Query: 333 CNCKVLSPSGL-------LIHCQE----RNIESLSDLRPPPQNPRKLILAGNIIHSLMKS 381
+ +L+ GL L++ E RN + + + P N RKL L N I+ + +
Sbjct: 206 LDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPN 265
Query: 382 DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGN 421
L L + NN + L +G F +L + +L L N
Sbjct: 266 AFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Score = 30.0 bits (66), Expect = 9.3
Identities = 16/64 (25%), Positives = 34/64 (53%)
Query: 59 ISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLH 118
+++P + +L L +N + + N FS L + + NN++++ G F+ L + QL
Sbjct: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLI 301
Query: 119 INHN 122
+ +N
Sbjct: 302 LRNN 305
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 99.8 bits (247), Expect = 1e-20
Identities = 64/215 (29%), Positives = 103/215 (47%), Gaps = 28/215 (13%)
Query: 69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILK 128
L L NN + + + F L N ++LG NN+ + AF L L++L ++HN +E ++
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 129 EDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTH 187
F GL NLE+L N+ I + FS +N LK LIL+ N +E+L + F + L +
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 188 LDLRGNQLQTLPYVGF------------------------LEHIGRILDLQLEDNKWACN 223
L L N++ ++ F L+ + ++ LQ N W CN
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECN 364
Query: 224 CDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSIL 258
C LL L+ WL + +I ++ C +PP +G L
Sbjct: 365 CKLLGLRDWLAS---SAITLNIYCQNPPSMRGRAL 396
Score = 90.1 bits (222), Expect = 8e-18
Identities = 63/241 (26%), Positives = 113/241 (46%), Gaps = 15/241 (6%)
Query: 363 QNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNH 422
+N L L N + + + +L L L +N IE ++ +F L L+ L L +
Sbjct: 204 ENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSR 263
Query: 423 LTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFS-- 480
+ +++ F G++NL++L L +N ++ + TF+ + L L L+ N + + F
Sbjct: 264 IRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENM 323
Query: 481 GVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTV 540
G L +NL N T L +L L L + NPW+C+C L+GL+ W L+ + +
Sbjct: 324 GASLKILNLSFNNLTALH-PRVLKPLSSLIHLQANSNPWECNCKLLGLRDW---LASSAI 379
Query: 541 TDDILCTSPGHLDKKELKALNSEILCPGLVN---------NPSMPTQTSYLMVTTPATTT 591
T +I C +P + + L+ +N +N +P + +T+ LM+ TT
Sbjct: 380 TLNIYCQNPPSMRGRALRYINITNCVTSSINVSRAWAVVKSPHIHHKTTALMMAWHKVTT 439
Query: 592 N 592
N
Sbjct: 440 N 440
Score = 76.6 bits (187), Expect = 9e-14
Identities = 52/161 (32%), Positives = 82/161 (50%), Gaps = 3/161 (1%)
Query: 341 SGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIE 400
+G I+C+ + S+ + P++ L L GN I + +S+L +L L+L N+ I
Sbjct: 40 TGRQINCRNLGLSSIP--KNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNIL 97
Query: 401 VLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPK 460
+ +F+ L L L+LN N + +L G+F GL NL LYL+YN + + G FN +
Sbjct: 98 YVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVS 157
Query: 461 LKVLYLNNNLLQVLPPHIFSG-VPLTKVNLKTNQFTHLPVS 500
++ L L N L VL F G V L ++L N + S
Sbjct: 158 VQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISES 198
Score = 67.4 bits (163), Expect = 5e-11
Identities = 43/136 (31%), Positives = 63/136 (46%), Gaps = 1/136 (0%)
Query: 69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILK 128
L L NN + L F GL N +++L +N ++ + G FN L ++ L++ N L +L
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172
Query: 129 EDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFV-PLTH 187
TF G+ L L NN I I S F L L L L N + +P N F + L
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRR 232
Query: 188 LDLRGNQLQTLPYVGF 203
L L N ++ + F
Sbjct: 233 LSLSHNPIEAIQPFAF 248
Score = 60.5 bits (145), Expect = 6e-09
Identities = 34/119 (28%), Positives = 64/119 (53%)
Query: 364 NPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 423
N R L L N + + + + +++ L+L NR+ VL G+F+ + L+ L L+ N++
Sbjct: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
Query: 424 TKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV 482
++S+ F L NL LYL N + ++ F + L+ L L++N ++ + P F G+
Sbjct: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGL 251
Score = 59.7 bits (143), Expect = 1e-08
Identities = 53/190 (27%), Positives = 89/190 (46%), Gaps = 9/190 (4%)
Query: 31 CDSLCN-CEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTN 89
C S+C C + INC G+ + + + P S F L L N ++ ++ ++ +GL +
Sbjct: 32 CSSVCQLCTGRQ----INCRNLGLSSIPK-NFPESTVF-LYLTGNNISYINESELTGLHS 85
Query: 90 AISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFIT 149
++++L +NI + AF L L L +N+N ++ L F GL NL L N ++
Sbjct: 86 LVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVS 145
Query: 150 VIEPSAFSKLNRLKVLILNDNAIESLPPNIF-RFVPLTHLDLRGNQLQTLPYVGFLEHIG 208
+ F+ L ++ L L N + L F V L LDL N + + GF +H+
Sbjct: 146 FVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGF-QHLE 204
Query: 209 RILDLQLEDN 218
+ L L N
Sbjct: 205 NLACLYLGSN 214
Score = 54.3 bits (129), Expect = 5e-07
Identities = 41/135 (30%), Positives = 58/135 (42%), Gaps = 4/135 (2%)
Query: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
L L N I L L L+L N++ + G F +L +Q L L N LT L
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172
Query: 428 KGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKV 487
G F+G+ L L L N I I F + L LYL +N L +P + F +
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLK---- 228
Query: 488 NLKTNQFTHLPVSNI 502
+L+ +H P+ I
Sbjct: 229 SLRRLSLSHNPIEAI 243
Score = 53.5 bits (127), Expect = 8e-07
Identities = 80/331 (24%), Positives = 134/331 (40%), Gaps = 38/331 (11%)
Query: 117 LHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLP 176
L++ N++ + E GL +L L DN+ I + P AF +L L L LN+N I+ L
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 177 PNIFR-FVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLEN 235
P IF+ + L +L L+ NQ+ +P G + + L L+ N+ L
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPR-GVFNDLVSVQYLNLQRNR-------------LTV 170
Query: 236 MPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSR 295
+ + +G V +IL R+ + SG HL N +
Sbjct: 171 LGSGTFVGMVALRILDLSNNNIL-RISE----------------SGFQHLE-----NLAC 208
Query: 296 MSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESL 355
+ + ++ K+P+ A ++ + + S P K L+ L+ R
Sbjct: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268
Query: 356 SDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNL-TRLQ 414
D N + LIL+ N + +L L L L NRI ++ +F N+ L+
Sbjct: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328
Query: 415 KLYLNGNHLTKLSKGMFLGLHNLEYLYLEYN 445
L L+ N+LT L + L +L +L N
Sbjct: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 99.8 bits (247), Expect = 1e-20
Identities = 77/234 (32%), Positives = 105/234 (44%), Gaps = 9/234 (3%)
Query: 342 GLLIHCQERNIESLSDLRPPPQNPRKLI------LAGNIIHSLMKSDLVEYFTLEMLHLG 395
G L QE ++S + PPQ +L L N I L S L L L
Sbjct: 214 GKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQ 273
Query: 396 NNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTF 455
N + VL G F + L L L N L +++G F L NL L L YNAI + G F
Sbjct: 274 WNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIF 333
Query: 456 NPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKVNLKTNQFTHLPVSNILDDLDLLTQIDL 514
+ +L LYL +N L L P +F + L ++L NQ T LP I D L + L
Sbjct: 334 RDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP-EGIFDTNYNLFNLAL 392
Query: 515 EDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALN-SEILCP 567
NPW C C L L W+Q+ + + C P +L + + ALN +++CP
Sbjct: 393 HGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCP 446
Score = 95.1 bits (235), Expect = 2e-19
Identities = 65/203 (32%), Positives = 93/203 (45%), Gaps = 3/203 (1%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEIL 127
+L L N +T L + F+ L N + L +N + + G F L L + HN LE +
Sbjct: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
Query: 128 KEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFR-FVPLT 186
E TF L NL L N IT + F L L L L N + +L P +F+ L
Sbjct: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLE 364
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVV 246
L L NQL TLP G + + +L L N W C+C L L WL+ + +
Sbjct: 365 LLSLSKNQLTTLP-EGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTY 423
Query: 247 CNSPPFFKGSILSRL-KKESICP 268
C P + KG ++ L +K+ +CP
Sbjct: 424 CAGPAYLKGQVVPALNEKQLVCP 446
Score = 77.4 bits (189), Expect = 5e-14
Identities = 98/378 (25%), Positives = 144/378 (38%), Gaps = 67/378 (17%)
Query: 72 LNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDT 131
LN L + F GL + + ++ ++ F+ L L +L +N N LE L E
Sbjct: 81 LNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGL 140
Query: 132 FHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLD-- 189
F L LE L N + + F L LK L L N + LP +F PLT L
Sbjct: 141 FQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFH--PLTSLQTL 198
Query: 190 -LRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCN 248
L N L LP G +G + +L L+ N + +PPQ + + C
Sbjct: 199 KLSNNALSGLPQ-GVFGKLGSLQELFLDSNN-------------ISELPPQ-VFSQLFC- 242
Query: 249 SPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSI-NDSRMSTKTTSILKLP 307
L RL + T L L+ +S+ N + +S + + LP
Sbjct: 243 ---------LERLWLQRNAIT------------HLPLSIFASLGNLTFLSLQWNMLRVLP 281
Query: 308 TKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRK 367
G + PC + L E LS+L R
Sbjct: 282 A-----------------GLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNL-------RS 317
Query: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427
L+L+ N I L + L L+LG+N + L F NL++L+ L L+ N LT L
Sbjct: 318 LMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Query: 428 KGMFLGLHNLEYLYLEYN 445
+G+F +NL L L N
Sbjct: 378 EGIFDTNYNLFNLALHGN 395
Score = 76.3 bits (186), Expect = 1e-13
Identities = 69/225 (30%), Positives = 108/225 (48%), Gaps = 16/225 (7%)
Query: 301 TSILKLPTKAPGLIPYITKP---STQL----PGPYCPIPCNCKVLSPSGLLIHCQERNIE 353
TS L T+A G P +TK +TQL P + +P + ++
Sbjct: 59 TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
Query: 354 SLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRL 413
+L+ L KL L N++ +L + LE LHL N+++ L F LT L
Sbjct: 119 NLTSLG-------KLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171
Query: 414 QKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQV 473
+ L L N L +L + +F L +L+ L L NA+ + G F + L+ L+L++N +
Sbjct: 172 KTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISE 231
Query: 474 LPPHIFSGV-PLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDN 517
LPP +FS + L ++ L+ N THLP+S I L LT + L+ N
Sbjct: 232 LPPQVFSQLFCLERLWLQRNAITHLPLS-IFASLGNLTFLSLQWN 275
Score = 65.9 bits (159), Expect = 2e-10
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 26/175 (14%)
Query: 69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILK 128
L + + L TN FS LT+ + L FN + + G F L L+ LH+ N L+ L
Sbjct: 102 LEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALP 161
Query: 129 ------------------------EDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKV 164
E+ FH L +L+ L+ NN ++ + F KL L+
Sbjct: 162 RRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQE 221
Query: 165 LILNDNAIESLPPNIF-RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDN 218
L L+ N I LPP +F + L L L+ N + LP + +G + L L+ N
Sbjct: 222 LFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP-LSIFASLGNLTFLSLQWN 275
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 99.0 bits (245), Expect = 2e-20
Identities = 87/288 (30%), Positives = 133/288 (46%), Gaps = 36/288 (12%)
Query: 326 GPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVE 385
G CP C C + + +HC R + S+ D PP N ++ L N + LM++D
Sbjct: 26 GKACPRRCACYMPTE----VHCTFRYLTSIPDSIPP--NVERINLGYNSLVRLMETDFSG 79
Query: 386 YFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYN 445
LE+L L +N I + + +F +L LQ L ++ N + KL K F GL +L L++++N
Sbjct: 80 LTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHN 139
Query: 446 AIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIF---SGVPLTKVN------LKTNQFTH 496
I+ I P F + L++++L N L L P F S + + K++ L N T
Sbjct: 140 NIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTS 199
Query: 497 LP--VSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDK 554
LP + + + DLD L L NPW C C L L WIQ+ P +
Sbjct: 200 LPQEMVSYMPDLDSLY---LHGNPWTCDCHLKWLSDWIQE-------------KPDVIKC 243
Query: 555 KELKALNSEILCPGLVNNPSMPTQTSYLMVTTPA--TTTNTADTILRS 600
K+ ++ +S CP L NP MV+ A T D+ L+S
Sbjct: 244 KKDRSPSSAQQCP-LCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKS 290
Score = 91.3 bits (225), Expect = 3e-18
Identities = 71/236 (30%), Positives = 107/236 (45%), Gaps = 24/236 (10%)
Query: 60 SVPPSRPFQLSLLN---NGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQ 116
S+P S P + +N N L L DFSGLT + L N I I F+ L L+
Sbjct: 50 SIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQV 109
Query: 117 LHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLP 176
L +++N + L++DTF+GL +L L D+N I I P F LN L+++ L N + L
Sbjct: 110 LKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLH 169
Query: 177 PN---------IFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLL 227
P+ IF+ + L L N L +LP + ++ + L L N W C+C L
Sbjct: 170 PDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQ-EMVSYMPDLDSLYLHGNPWTCDCHLK 228
Query: 228 QLKTWLENMP----------PQSIIGDVVCNSPPFFKGSILSRLKKESI-CPTPPV 272
L W++ P P S +C +P KG L+ + + C P +
Sbjct: 229 WLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTI 284
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 98.2 bits (243), Expect = 3e-20
Identities = 78/263 (29%), Positives = 116/263 (44%), Gaps = 14/263 (5%)
Query: 309 KAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKL 368
+AP L+P + L CP C C + + C + + PP + L
Sbjct: 4 RAPALLPLLLL-LLPLRAAGCPAACRCYSAT-----VECGALRLRVVPLGIPP--GTQTL 55
Query: 369 ILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSK 428
L N I L L L L+L NN + LE G+F RL +L L N L L
Sbjct: 56 FLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRS 115
Query: 429 GMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGV-PLTKV 487
G F+GL L LYL N + +L TF +P+L+ L+L N +++L +G+ L +
Sbjct: 116 GAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALL 175
Query: 488 NLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTD---DI 544
+L NQ + L L L + L +NPW C C L L WI++ + +T I
Sbjct: 176 DLSRNQLGTIS-REALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKI 234
Query: 545 LCTSPGHLDKKE-LKALNSEILC 566
+C P L + L +S ++C
Sbjct: 235 MCAEPPRLALQSLLDVSHSSLIC 257
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/208 (26%), Positives = 87/208 (41%), Gaps = 29/208 (13%)
Query: 92 SIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVI 151
++ L NNIA +E GA L L++L++++NSL L+ F L L +N + +
Sbjct: 54 TLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGL 113
Query: 152 EPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-------------------------LT 186
AF L +L+VL L N + L F +P L
Sbjct: 114 RSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLA 173
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIG--- 243
LDL NQL T+ L+ + + L+L +N W C+C L L W++ + +
Sbjct: 174 LLDLSRNQLGTISREA-LQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDR 232
Query: 244 DVVCNSPPFFKGSILSRLKKESICPTPP 271
++C PP L + S+ PP
Sbjct: 233 KIMCAEPPRLALQSLLDVSHSSLICIPP 260
Score = 54.7 bits (130), Expect = 4e-07
Identities = 34/106 (32%), Positives = 53/106 (50%)
Query: 65 RPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSL 124
R +L+L +N L L + F GL ++L N +A + F L L++LH+ NS+
Sbjct: 99 RLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSI 158
Query: 125 EILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDN 170
E+L++ GL +L L N + I A L L+VL L +N
Sbjct: 159 ELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTEN 204
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 97.1 bits (240), Expect = 6e-20
Identities = 75/283 (26%), Positives = 124/283 (43%), Gaps = 57/283 (20%)
Query: 362 PQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVL--EEGSFMNLTRLQKLYLN 419
P+N R L L N I ++ ++ L + LE LHL +N I + E+G+F L+ L+L+
Sbjct: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLS 167
Query: 420 GNHLTKLSKGM---------------------FLGLHNLEYLYLEYNAI--KEILPGTFN 456
NHL+ + G+ F L +LE L ++ N + K I GTF+
Sbjct: 168 KNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFS 227
Query: 457 PMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVS---------------- 500
+ KLK + N L PP + G L ++ L+ NQ H+P++
Sbjct: 228 HLTKLKEFSIVRNSLSHPPPDL-PGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNN 286
Query: 501 -------NILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLD 553
+ D+L L Q+ +NPW C C + + +W++ + + +C P +
Sbjct: 287 QLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVR 346
Query: 554 KKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADT 596
++ LN +L S PT T L + TPA +T + T
Sbjct: 347 GMAVRELNMNLL--------SCPTTTPGLPLFTPAPSTASPTT 381
Score = 73.6 bits (179), Expect = 7e-13
Identities = 69/276 (25%), Positives = 118/276 (42%), Gaps = 40/276 (14%)
Query: 68 QLSLLNNGLTMLHTNDFSGLTNAISIHLGF---NNIADIEIGAFNGLGLLKQLHINHNSL 124
+L L +N ++ + D AIS+ L F N+++ + +G L ++L ++ N +
Sbjct: 137 ELHLDDNSISTVGVED-GAFREAISLKLLFLSKNHLSSVPVGLPVDL---QELRVDENRI 192
Query: 125 EILKEDTFHGLENLEFLQADNNFITV--IEPSAFSKLNRLKVLILNDNAIESLPPNI--- 179
++ + F L +LE L D N +T I FS L +LK + N++ PP++
Sbjct: 193 AVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGT 252
Query: 180 -----------FRFVPLT---------HLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNK 219
+PLT LD+ NQL+ L G +++ + L +N
Sbjct: 253 HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQ-GVFDNLSNLKQLTARNNP 311
Query: 220 WACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESI-CPTP----PVYE 274
W C+C + + WL+ +P + +C P +G + L + CPT P++
Sbjct: 312 WFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFT 371
Query: 275 EHEDPSGSLHLAATSSI-NDSRMST-KTTSILKLPT 308
+ T SI N SR T T + KLPT
Sbjct: 372 PAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPT 407
Score = 42.4 bits (98), Expect = 0.002
Identities = 36/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)
Query: 41 DGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNI 100
DG +L N KGI + + + F S++ N L+ D G T+ I ++L N I
Sbjct: 212 DGNLLTN---KGIAEGTFSHLTKLKEF--SIVRNSLSH-PPPDLPG-THLIRLYLQDNQI 264
Query: 101 ADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
I + AF+ L L++L I++N L +L + F L NL+ L A NN
Sbjct: 265 NHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNN 310
Score = 34.3 bits (77), Expect = 0.50
Identities = 56/234 (23%), Positives = 99/234 (42%), Gaps = 49/234 (20%)
Query: 10 SSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQL 69
S L+ + L+SQ L + C S+C C+ + C + + SVP P +
Sbjct: 18 SWLIISLGLYSQVSKLLA---CPSVCRCDRN----FVYCNERSLT-----SVPLGIPEGV 65
Query: 70 SLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKE 129
++L LH N + +H N+ + +++ N L+ E
Sbjct: 66 TVL-----YLHNNQINNAGFPAELH----NVQSVHT-----------VYLYGNQLD---E 102
Query: 130 DTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIES--LPPNIFR-FVPLT 186
+ +N+ L N I I +A ++L +L+ L L+DN+I + + FR + L
Sbjct: 103 FPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLK 162
Query: 187 HLDLRGNQLQTLPYVGFLEHIGRILDLQ---LEDNKWACNCDL-LQLKTWLENM 236
L L N L ++P +G +DLQ +++N+ A D+ Q T LE +
Sbjct: 163 LLFLSKNHLSSVP-------VGLPVDLQELRVDENRIAVISDMAFQNLTSLERL 209
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 94.7 bits (234), Expect = 3e-19
Identities = 77/284 (27%), Positives = 117/284 (41%), Gaps = 49/284 (17%)
Query: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPS---RPFQLSLLNNGLTMLHTNDFSGL 87
C C C+ + C KG+ + VPP+ R +L L +N +T + DF+ +
Sbjct: 20 CPKRCVCQILSPNLATLCAKKGL-----LFVPPNIDRRTVELRLADNFVTNIKRKDFANM 74
Query: 88 TNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNF 147
T+ + + L N I+ I AF L L+ LH+N N L + D F GL NL L +NN
Sbjct: 75 TSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQ 134
Query: 148 ITVIEPSAF------------------------SKLNRLKVLILNDNAIESLPPNIFRFV 183
+T+I +AF K+ L L L+ N I+++P F +
Sbjct: 135 LTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHL 194
Query: 184 -PLTHLDLRGNQLQTLPYVGFLEHIGRI----------LDLQLEDNKWACNCDLLQLKTW 232
+T LD+ N+LQ LP + + L N CNC+LL W
Sbjct: 195 HKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELL----W 250
Query: 233 LENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEH 276
L + + + C SPP G + +E PP+ H
Sbjct: 251 LRRLSREDDL--ETCASPPLLTGRYFWSIPEEEFLCEPPLITRH 292
Score = 85.9 bits (211), Expect = 1e-16
Identities = 73/278 (26%), Positives = 123/278 (44%), Gaps = 53/278 (19%)
Query: 329 CPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLI---LAGNIIHSLMKSDLVE 385
CP C C++LSP+ L C ++ + L PP R+ + LA N + ++ + D
Sbjct: 20 CPKRCVCQILSPN-LATLCAKKGL-----LFVPPNIDRRTVELRLADNFVTNIKRKDFAN 73
Query: 386 YFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLY---- 441
+L L L N I + +F +L L+ L+LN N LTK++ MF GL NL +L
Sbjct: 74 MTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNN 133
Query: 442 --------------------LEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSG 481
L YN ++ I M L L L++N++ +P FS
Sbjct: 134 QLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSH 193
Query: 482 V-PLTKVNLKTNQFTHLPVSNILDDLDLLT----------QIDLEDNPWDCSCDLVGLQQ 530
+ +T++++ +N+ LP + +L + NP C+C+L+
Sbjct: 194 LHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELL---- 249
Query: 531 WIQKLSKNTVTDDI-LCTSPGHLDKKELKAL-NSEILC 566
W+++LS+ DD+ C SP L + ++ E LC
Sbjct: 250 WLRRLSRE---DDLETCASPPLLTGRYFWSIPEEEFLC 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,554,247
Number of Sequences: 37866
Number of extensions: 1682507
Number of successful extensions: 9258
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 245
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 5590
Number of HSP's gapped (non-prelim): 1734
length of query: 841
length of database: 18,247,518
effective HSP length: 111
effective length of query: 730
effective length of database: 14,044,392
effective search space: 10252406160
effective search space used: 10252406160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.