Search of human proteins with 39930571

Search of human proteins with 39930571

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39930571 leucine rich repeat containing 56 [Homo sapiens]
         (542 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39930571 leucine rich repeat containing 56 [Homo sapiens]         1114   0.0  
gi|218931217 leucine rich repeat containing 61 [Homo sapiens]          58   2e-08
gi|13027616 leucine rich repeat containing 61 [Homo sapiens]           58   2e-08
gi|117414162 sodium channel associated protein 2 isoform a [Homo...    52   1e-06
gi|4826651 hypothetical protein LOC755 [Homo sapiens]                  52   2e-06
gi|164607156 axonemal dynein light chain 1 [Homo sapiens]              51   2e-06
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s...    50   7e-06
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa...    50   7e-06
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    47   6e-05
gi|21389483 leucine-rich repeats and guanylate kinase domain con...    46   1e-04
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              46   1e-04
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                   45   1e-04
gi|190684671 mitogen-activated protein kinase binding protein 1 ...    45   1e-04
gi|190684677 mitogen-activated protein kinase binding protein 1 ...    45   1e-04
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap...    45   2e-04
gi|40556370 PHD finger protein 15 [Homo sapiens]                       44   3e-04
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo...    44   3e-04
gi|223718151 leucine rich transmembrane and 0-methyltransferase ...    44   4e-04
gi|21687175 leucine rich transmembrane and 0-methyltransferase d...    44   4e-04
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    44   4e-04
gi|24308207 leucine rich repeat containing 47 [Homo sapiens]           44   4e-04
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     44   4e-04
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    44   5e-04
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    44   5e-04
gi|238859651 pleckstrin homology domain containing family A memb...    43   8e-04
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo...    43   8e-04
gi|117414154 sodium channel associated protein 2 isoform b [Homo...    43   8e-04
gi|171543895 ataxin 2 [Homo sapiens]                                   42   0.001
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap...    42   0.001
gi|31324577 molecule interacting with Rab13 [Homo sapiens]             42   0.001

>gi|39930571 leucine rich repeat containing 56 [Homo sapiens]
          Length = 542

 Score = 1114 bits (2882), Expect = 0.0
 Identities = 542/542 (100%), Positives = 542/542 (100%)

Query: 1   MDLGWDRSRGPRRSTSSVRVRELSWQGLHNPCPQSKGPGSQRDRLGEQLVEEYLSPARLQ 60
           MDLGWDRSRGPRRSTSSVRVRELSWQGLHNPCPQSKGPGSQRDRLGEQLVEEYLSPARLQ
Sbjct: 1   MDLGWDRSRGPRRSTSSVRVRELSWQGLHNPCPQSKGPGSQRDRLGEQLVEEYLSPARLQ 60

Query: 61  ALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQLKLNGSHLGSLRDLGTSLGHLQV 120
           ALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQLKLNGSHLGSLRDLGTSLGHLQV
Sbjct: 61  ALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQLKLNGSHLGSLRDLGTSLGHLQV 120

Query: 121 LWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQVRY 180
           LWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQVRY
Sbjct: 121 LWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQVRY 180

Query: 181 LQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQLQVLDEVPAAHTGPP 240
           LQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQLQVLDEVPAAHTGPP
Sbjct: 181 LQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQLQVLDEVPAAHTGPP 240

Query: 241 APPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVR 300
           APPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVR
Sbjct: 241 APPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVR 300

Query: 301 GGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPEQLPQHRPG 360
           GGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPEQLPQHRPG
Sbjct: 301 GGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPEQLPQHRPG 360

Query: 361 DPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEE 420
           DPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEE
Sbjct: 361 DPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEE 420

Query: 421 QVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLR 480
           QVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLR
Sbjct: 421 QVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLR 480

Query: 481 VLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAARPPRAAELSHPSPV 540
           VLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAARPPRAAELSHPSPV
Sbjct: 481 VLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAARPPRAAELSHPSPV 540

Query: 541 PT 542
           PT
Sbjct: 541 PT 542


>gi|218931217 leucine rich repeat containing 61 [Homo sapiens]
          Length = 259

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 49/133 (36%), Positives = 66/133 (49%), Gaps = 7/133 (5%)

Query: 98  LKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLC 157
           LKL G  L  L  LG  LG L+ L L+   L  L  +ASL  L  L  S N ++ L PL 
Sbjct: 36  LKLRGLGLADLGCLGECLG-LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLA 94

Query: 158 LLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRA 217
             E L+ L+  GN +   GQ++ L   P L  L L   L  L      +N +    +Y A
Sbjct: 95  TCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARL------SNPLCANPSYWA 148

Query: 218 EVRKLIPQLQVLD 230
            VR+L+P L+V+D
Sbjct: 149 AVRELLPGLKVID 161


>gi|13027616 leucine rich repeat containing 61 [Homo sapiens]
          Length = 259

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 49/133 (36%), Positives = 66/133 (49%), Gaps = 7/133 (5%)

Query: 98  LKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLC 157
           LKL G  L  L  LG  LG L+ L L+   L  L  +ASL  L  L  S N ++ L PL 
Sbjct: 36  LKLRGLGLADLGCLGECLG-LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLA 94

Query: 158 LLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRA 217
             E L+ L+  GN +   GQ++ L   P L  L L   L  L      +N +    +Y A
Sbjct: 95  TCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARL------SNPLCANPSYWA 148

Query: 218 EVRKLIPQLQVLD 230
            VR+L+P L+V+D
Sbjct: 149 AVRELLPGLKVID 161


>gi|117414162 sodium channel associated protein 2 isoform a [Homo
           sapiens]
          Length = 1032

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 47/144 (32%), Positives = 71/144 (49%), Gaps = 12/144 (8%)

Query: 91  HLPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNI 150
           H+ NL  L L+ + +  +  L T L  L  L L+   +  ++G+  L  L  L  SYN+I
Sbjct: 63  HIWNLQHLDLSSNQISRIEGLNT-LTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNHI 121

Query: 151 SDLSPLCLLE----QLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPT 206
            DLS L  L     +L  +DL  N ++ +  +  LQ    L  LT   NL+  +   G  
Sbjct: 122 DDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHL--LQCMVGLHFLT---NLILEKD--GDD 174

Query: 207 NKVPRGYNYRAEVRKLIPQLQVLD 230
           N V R   YRA + + +PQL++LD
Sbjct: 175 NPVCRLPGYRAVILQTLPQLRILD 198


>gi|4826651 hypothetical protein LOC755 [Homo sapiens]
          Length = 256

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 40/140 (28%), Positives = 62/140 (44%), Gaps = 10/140 (7%)

Query: 128 LADLDGIASLPALKELYASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQVRYLQLCPRL 187
           L D+     +P+L+ +  S N+IS L P+   ++L  L L  N +  L ++ YL+  PRL
Sbjct: 30  LTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRL 89

Query: 188 AMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQLQVLDEVPAAHTGPPAPPRLSQ 247
            +L L  N  C   +P         + YR  V + +P+LQ LD                +
Sbjct: 90  RVLWLAEN-PCCGTSP---------HRYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGE 139

Query: 248 DWLAVKEAIKKGNGLPPLDC 267
           +  A  E    G+G P L C
Sbjct: 140 EITAAPEREGTGHGGPKLCC 159


>gi|164607156 axonemal dynein light chain 1 [Homo sapiens]
          Length = 190

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 40/143 (27%), Positives = 73/143 (51%), Gaps = 10/143 (6%)

Query: 92  LPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASL-PALKELYASYNNI 150
           L N ++L L+ + +  + +L   L +L++L L R  + +L+G+ ++   L+EL+ SYN I
Sbjct: 47  LANCEKLSLSTNCIEKIANLN-GLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFI 105

Query: 151 SDLSPLCLLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVP 210
             L  + ++++L++L +  N V+D  +   L   P L  L   GN +          K  
Sbjct: 106 EKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPL--------EEKHS 157

Query: 211 RGYNYRAEVRKLIPQLQVLDEVP 233
              N+  E  K +P+L+ LD  P
Sbjct: 158 AENNWIEEATKRVPKLKKLDGTP 180


>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
           sapiens]
          Length = 343

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 15/141 (10%)

Query: 92  LPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNIS 151
           L +L  ++L G+ L S   LG +L  L+ L+LA+  L  ++G+  L  L  L+   N I 
Sbjct: 178 LISLHTVELRGNQLEST--LGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQID 235

Query: 152 DLSPLCL-LEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVP 210
            LS     ++ L+ L+L GN V +LG++  L+  P+L  L L  N     P    T    
Sbjct: 236 TLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDN-----PCTDET---- 286

Query: 211 RGYNYRAEVRKLIPQLQVLDE 231
              +YR E    +P L+ LD+
Sbjct: 287 ---SYRQEALVQMPYLERLDK 304



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 18/111 (16%)

Query: 105 LGSLRDLGTSLGHLQV-LWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLE 163
           L  L   G  L H  V L +    L D+  + S   L+ +  S N+++DLSPL  L  L 
Sbjct: 57  LSLLCKTGNGLAHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLL 116

Query: 164 VLDLEGNSVE--DLGQVRYLQLC---------------PRLAMLTLEGNLV 197
            L  +GN +    + ++ YLQ+                PRL  L L+GN +
Sbjct: 117 WLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSI 167


>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
           sapiens]
          Length = 343

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 15/141 (10%)

Query: 92  LPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNIS 151
           L +L  ++L G+ L S   LG +L  L+ L+LA+  L  ++G+  L  L  L+   N I 
Sbjct: 178 LISLHTVELRGNQLEST--LGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQID 235

Query: 152 DLSPLCL-LEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVP 210
            LS     ++ L+ L+L GN V +LG++  L+  P+L  L L  N     P    T    
Sbjct: 236 TLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDN-----PCTDET---- 286

Query: 211 RGYNYRAEVRKLIPQLQVLDE 231
              +YR E    +P L+ LD+
Sbjct: 287 ---SYRQEALVQMPYLERLDK 304



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 33/111 (29%), Positives = 49/111 (44%), Gaps = 18/111 (16%)

Query: 105 LGSLRDLGTSLGHLQV-LWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLE 163
           L  L   G  L H  V L +    L D+  + S   L+ +  S N+++DLSPL  L  L 
Sbjct: 57  LSLLCKTGNGLAHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLL 116

Query: 164 VLDLEGNSVE--DLGQVRYLQLC---------------PRLAMLTLEGNLV 197
            L  +GN +    + ++ YLQ+                PRL  L L+GN +
Sbjct: 117 WLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSI 167


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 58/210 (27%), Positives = 77/210 (36%), Gaps = 22/210 (10%)

Query: 350 PPEQLPQHRPGDPAASTSTPEPDPADSSDFL-ALAGLRAWREHGVRPLPYRHPESQ--QE 406
           PPE+ P   P  P AS  +P P+   +S    AL   R   E  + P P   P S   + 
Sbjct: 452 PPEESPTSPP--PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPES 509

Query: 407 GAVAPW--GPRRVPEEQVHQAEPKTPSSPPSLAS--------EPSGTSSQHLVPSPPKH- 455
              +P    P   PEE       +TP SPP  AS         P     + L  SPP   
Sbjct: 510 SPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEA 569

Query: 456 ----PRPRDSGSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPR 511
               P P +S  S P   + +       R+   +             L     ASRLSP 
Sbjct: 570 SRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPP 629

Query: 512 AQGCPGPKPAPDAAARPPRAAELSHPSPVP 541
            +  P   P  ++   PP   E+S  SP+P
Sbjct: 630 PEDSPMSPPPEESPMSPP--PEVSRLSPLP 657



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 79/296 (26%), Positives = 99/296 (33%), Gaps = 67/296 (22%)

Query: 263 PPLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVRGGPLPEGL-----LSED-LAPE 316
           PP + P   P     PE S       ASR  P    +   PLPE L     L E  L+P 
Sbjct: 443 PPEESPLSPP-----PEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPP 497

Query: 317 DNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPEQLPQHRPGDPAASTSTPEPDPADS 376
              S L+         +P   L E         PPE+ P      P+ +  TP   P ++
Sbjct: 498 PEESPLSPPPES----SPFSPLEE-----SPLSPPEESP------PSPALETPLSPPPEA 542

Query: 377 SDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPK-TPSSPPS 435
           S          + E  + P P   P S    A     P   PEE      P+ +P SPP 
Sbjct: 543 SPLSP-----PFEESPLSPPPEELPTSPPPEASRLSPP---PEESPMSPPPEESPMSPPP 594

Query: 436 LASE--------PSGTSSQHLVPSPPKH-----PRPRDSGSSSPRWSTDLQSRGRRLRVL 482
            AS         P     +    SPP       P P DS  S P   + +       R  
Sbjct: 595 EASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSR-- 652

Query: 483 GSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCP-GPKPAPDAAARPPRAAELSHP 537
                           L  L V SRLSP  +  P  P P     + PP A+ LS P
Sbjct: 653 ----------------LSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPP 692



 Score = 37.0 bits (84), Expect = 0.046
 Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 14/201 (6%)

Query: 351  PEQLPQHRPGDPAASTS--TPEPDPADSSDFLALAGLRAWREHGVRPLPY-----RHPES 403
            PE+LP    G+P+ S     P+P P   S  +  A   A    G    P+       PES
Sbjct: 912  PEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPES 971

Query: 404  QQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGS 463
                 +        PE      EP  P   P     P G +S  L+   P    P    S
Sbjct: 972  PLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHS 1031

Query: 464  SSPRWSTDLQSR--GRRLRVLGSWGP-GLGDGVAAVPVLRALEVASRLSPRAQGCPGPKP 520
              P+ S   Q       L V     P G   GV+    L  +E      P    CP  +P
Sbjct: 1032 LVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPE---CPALEP 1088

Query: 521  APDAAARPPRAAELSHPSPVP 541
            +   +  P    +LS P+P P
Sbjct: 1089 SA-TSPLPSPMGDLSCPAPSP 1108



 Score = 33.1 bits (74), Expect = 0.66
 Identities = 69/254 (27%), Positives = 85/254 (33%), Gaps = 48/254 (18%)

Query: 236  HTGPPAPPRL--------------SQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELS 281
            HT PP  PR               S D LAV E+   G G          P       L 
Sbjct: 2227 HTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGESRKALE 2286

Query: 282  LPETQSRASRP--WPFSLLVRGGPLPEGLLS--EDLAPEDNTSSLTHGAGQVLCGNPTKG 337
            + + +  AS P   P +L     P     L   E   P+   + LT  A QV   +P  G
Sbjct: 2287 VKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLG 2346

Query: 338  LRERRH---QCQAREPPEQLPQHRPG---DPAASTS-TPEPDPADSSDFLALAGLRAWRE 390
            LR +     Q  A  PP      RPG   DP A    TP P P       AL        
Sbjct: 2347 LRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPP------ 2400

Query: 391  HGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVP 450
               R LP   P S+   +         P+ Q     P TP    + A  PS  + +   P
Sbjct: 2401 ---RSLP-SDPFSRVPAS---------PQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSP 2447

Query: 451  S----PPKHPRPRD 460
                 PP  P+ RD
Sbjct: 2448 DPYSRPPSRPQSRD 2461


>gi|21389483 leucine-rich repeats and guanylate kinase domain
           containing [Homo sapiens]
          Length = 825

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 31/102 (30%), Positives = 54/102 (52%), Gaps = 2/102 (1%)

Query: 94  NLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDL 153
           NL  L L  + + ++  L      +++L L+   +  + G+  L AL+ L  S+N IS L
Sbjct: 238 NLIHLSLANNKITTINGLNKL--PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSL 295

Query: 154 SPLCLLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGN 195
             L   + LEV++LE N + +L ++ Y++  P L +L L  N
Sbjct: 296 QGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLEN 337



 Score = 37.0 bits (84), Expect = 0.046
 Identities = 30/103 (29%), Positives = 45/103 (43%), Gaps = 25/103 (24%)

Query: 117 HLQVLWLARCGLADLDGIASLPALKELYASYNN----------------------ISDLS 154
           HLQ L L+   + DL  ++ +P L EL AS NN                      IS++ 
Sbjct: 150 HLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEIC 209

Query: 155 PLCLLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLV 197
            L     L  L L+GN +E++     L++C  L  L+L  N +
Sbjct: 210 DLSAYHALTKLILDGNEIEEISG---LEMCNNLIHLSLANNKI 249


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 58/204 (28%), Positives = 78/204 (38%), Gaps = 21/204 (10%)

Query: 350 PPEQLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAV 409
           PP   P + P  P     T +P+    +   +       ++    P P   PE +Q+ ++
Sbjct: 730 PPSPPPSYHPPPPP----TKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE-EQDLSM 784

Query: 410 APWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLV--------PSPPKHPRPRDS 461
           A + P       V   EP  PS  P L S P+ +SS            P PP  P     
Sbjct: 785 ADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAP 844

Query: 462 GSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPG--PK 519
            SS+P     L  +   +      GP   D V A  V  +L    RL  R+ G PG  P 
Sbjct: 845 ASSAPGHVAKLPQK-EPVGCSKGGGPPRED-VGAPLVTPSLLQMVRL--RSVGAPGGAPT 900

Query: 520 PA--PDAAARPPRAAELSHPSPVP 541
           PA  P A  +P R A     SPVP
Sbjct: 901 PALGPSAPQKPLRRALSGRASPVP 924



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 70/293 (23%), Positives = 105/293 (35%), Gaps = 65/293 (22%)

Query: 201  PAPGPTNKVPRGYNYRAEVRKLIPQLQVLDEVPAAHTGPPAPPRLSQDWLAVKEAIKKGN 260
            PAP P +  P        V KL PQ +     P   +    PPR       V  ++ +  
Sbjct: 840  PAPAPASSAP------GHVAKL-PQKE-----PVGCSKGGGPPREDVGAPLVTPSLLQMV 887

Query: 261  GLPPLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVRGGPLPEGLLSEDLAPEDNTS 320
             L  +  P GAP   L P        S   +P   +L  R  P+P               
Sbjct: 888  RLRSVGAPGGAPTPALGP--------SAPQKPLRRALSGRASPVPA-------------- 925

Query: 321  SLTHGAGQVLCGNPTKGLRER-RHQCQAREPPEQLPQHRPGDPAASTSTPEPDPADSSDF 379
                         P+ GL    R +  +    E L   +P  P  +   P   PA ++ F
Sbjct: 926  -------------PSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASF 972

Query: 380  LALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASE 439
            +   G R  +    RP+        Q   VA    R + E++  QA  K+P +PP +A +
Sbjct: 973  IFSKGSRKLQLE--RPVSPETQADLQRNLVAEL--RSISEQRPPQAPKKSPKAPPPVARK 1028

Query: 440  PS-GTSSQHLVPSPPKHPR------PRDSG--SSSPRWSTDLQSRGRRLRVLG 483
            PS G       P+ P +PR      P  +G   +  R   +L   G  L+++G
Sbjct: 1029 PSVGVPP----PASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVG 1077



 Score = 36.6 bits (83), Expect = 0.060
 Identities = 50/199 (25%), Positives = 72/199 (36%), Gaps = 57/199 (28%)

Query: 350 PPEQLPQHRPGDPAASTSTPEPDPADSSDFLAL--AGLRAWREHGVR------PLPYRHP 401
           PP Q    R      ST       A++SD L++  +G  + R   +R      P P R  
Sbjct: 453 PPPQGGSGRGSPSGGST-------AEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTH 505

Query: 402 ESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDS 461
              Q G   P GP  +P +   + +P+ P  P +  SE +G +     P PP        
Sbjct: 506 SLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAA-----PCPP-------- 552

Query: 462 GSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVL---RALEVASRLSPRA------ 512
                                 SW PGL  G +  P     R L  +S  S ++      
Sbjct: 553 ------------------NPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLP 594

Query: 513 -QGCPGPKPAPDAAARPPR 530
            +G  GP PA    A+PP+
Sbjct: 595 PKGLAGP-PASPGKAQPPK 612



 Score = 33.9 bits (76), Expect = 0.39
 Identities = 52/207 (25%), Positives = 70/207 (33%), Gaps = 37/207 (17%)

Query: 340 ERRHQCQAREPPEQLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYR 399
           ER+ Q Q   PP        G   A  +   P+PA+S           W   G+ P   R
Sbjct: 526 ERKQQPQLPRPPTT-----GGSEGAGAAPCPPNPANS-----------WVP-GLSPGGSR 568

Query: 400 HPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPR 459
            P    E  ++P           + ++  TP+ PP   + P  +  +   P P +    R
Sbjct: 569 RPPRSPERTLSP--------SSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLR 620

Query: 460 DSGSSSPRWSTDLQSRGRRLRVLGSWGP----GLGDGVAAVPVLRALEVASRLSPRAQGC 515
             G+S     T L S           GP     LGD     P     +V +  SP     
Sbjct: 621 SPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPP---HPKVPAPFSP----- 672

Query: 516 PGPKPAPDAAARPPRAAELSHPSPVPT 542
           P  KP     A P  AA    P PV T
Sbjct: 673 PPSKPRSPNPAAPALAAPAVVPGPVST 699


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 57/236 (24%), Positives = 79/236 (33%), Gaps = 36/236 (15%)

Query: 311  EDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREP-----PEQLPQHRPGDPAAS 365
            E+L P+    S + G G     +P     +     +   P     P + P   PG P+A 
Sbjct: 1023 EELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQ 1082

Query: 366  TSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQA 425
            +S  +  PA                    PLP + P    E    P  P R        A
Sbjct: 1083 SSPIDAQPAT-------------------PLPQKDPAQPLEPKRPP--PPRPVAPPTRPA 1121

Query: 426  EPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSW 485
             P+ P  PPS A  P+ T  +   P  P   R  + G S P     L   G         
Sbjct: 1122 PPQRPP-PPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARP 1180

Query: 486  GPGLGDGVAAVPVLRALEVASRLSPRAQGCPG---------PKPAPDAAARPPRAA 532
                  GV + P   A   A RL+P +Q             P+P    AA PP+++
Sbjct: 1181 TIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS 1236



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 60/264 (22%), Positives = 85/264 (32%), Gaps = 37/264 (14%)

Query: 214  NYRAEVRKLIPQLQVLDEVPAAHTGPPAPPRLSQDW-------------LAVKEAIKKGN 260
            +Y AEV +L+PQ           T P + PR S                +    A  +  
Sbjct: 1017 DYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTP 1076

Query: 261  GLP-----PLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVRGGPLPEGLLSEDLAP 315
            G P     P+D     P+ + DP  + P    R   P P +   R  P P+        P
Sbjct: 1077 GPPSAQSSPIDAQPATPLPQKDP--AQPLEPKRPPPPRPVAPPTRPAP-PQ-------RP 1126

Query: 316  EDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPEQLPQHRPGDPAASTSTPEPDPAD 375
               + + +    +   G P      R+      +P  Q     PG    ST+ P   P  
Sbjct: 1127 PPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPR- 1185

Query: 376  SSDFLALAG-LRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPP 434
                   AG + A + H         PESQ + +    G   +PE    QA     SS P
Sbjct: 1186 -------AGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLP 1238

Query: 435  SLASEPSGTSSQHLVPSPPKHPRP 458
              A            P P   P+P
Sbjct: 1239 PPAQRLQEPLVPVAAPMPQSGPQP 1262


>gi|190684671 mitogen-activated protein kinase binding protein 1
            isoform a [Homo sapiens]
          Length = 1508

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 92/393 (23%), Positives = 144/393 (36%), Gaps = 65/393 (16%)

Query: 166  DLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQ 225
            D EG   ED G    L   P LA  T +     L   P P   +PR  ++  E+ +    
Sbjct: 782  DKEG---EDEGTEEELPALPVLAKSTKKA----LASVPSPA--LPRSLSHW-EMSRAQES 831

Query: 226  LQVLDEVPAAHTGPPAPPRLSQDWLAVK----------EAIKKGNGLPPLDC-------P 268
            +  LD  PAA+ GP    R  Q  + +           E +      P  D        P
Sbjct: 832  VGFLDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGP 891

Query: 269  RGAPIRRLDPELSLPETQS---RASRPWPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHG 325
            R      L+  L+    +    +AS+P  +  ++R     EG+ ++DL P      + + 
Sbjct: 892  RKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYP 951

Query: 326  AGQVLCGNPTKGLRERRHQCQAR------EPPEQLPQHRPGDPAAST-------STPE-- 370
                   NPT    E + Q  AR       P  +  +    D A S        S+PE  
Sbjct: 952  EPS---DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHP 1008

Query: 371  PDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTP 430
             + ++S++ L++ G+ +  E    P      E ++EG + P+G        + +  P+TP
Sbjct: 1009 TEDSESTEPLSVDGISSDLE---EPAEGDEEEEEEEGGMGPYG--------LQEGSPQTP 1057

Query: 431  SSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSWGPGLG 490
                 L       +S     +P + P   +S S S R+   +Q+R  R     S    L 
Sbjct: 1058 DQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALM 1117

Query: 491  DGVAAVPVLRALEVASRLSPRAQGCPGPKPAPD 523
               A VP       AS   PR  G   P   P+
Sbjct: 1118 SRPAQVP------QASGEQPRGNGANPPGAPPE 1144


>gi|190684677 mitogen-activated protein kinase binding protein 1
            isoform b [Homo sapiens]
          Length = 1514

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 92/393 (23%), Positives = 144/393 (36%), Gaps = 65/393 (16%)

Query: 166  DLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQ 225
            D EG   ED G    L   P LA  T +     L   P P   +PR  ++  E+ +    
Sbjct: 788  DKEG---EDEGTEEELPALPVLAKSTKKA----LASVPSPA--LPRSLSHW-EMSRAQES 837

Query: 226  LQVLDEVPAAHTGPPAPPRLSQDWLAVK----------EAIKKGNGLPPLDC-------P 268
            +  LD  PAA+ GP    R  Q  + +           E +      P  D        P
Sbjct: 838  VGFLDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGP 897

Query: 269  RGAPIRRLDPELSLPETQS---RASRPWPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHG 325
            R      L+  L+    +    +AS+P  +  ++R     EG+ ++DL P      + + 
Sbjct: 898  RKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYP 957

Query: 326  AGQVLCGNPTKGLRERRHQCQAR------EPPEQLPQHRPGDPAAST-------STPE-- 370
                   NPT    E + Q  AR       P  +  +    D A S        S+PE  
Sbjct: 958  EPS---DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHP 1014

Query: 371  PDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTP 430
             + ++S++ L++ G+ +  E    P      E ++EG + P+G        + +  P+TP
Sbjct: 1015 TEDSESTEPLSVDGISSDLE---EPAEGDEEEEEEEGGMGPYG--------LQEGSPQTP 1063

Query: 431  SSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSWGPGLG 490
                 L       +S     +P + P   +S S S R+   +Q+R  R     S    L 
Sbjct: 1064 DQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALM 1123

Query: 491  DGVAAVPVLRALEVASRLSPRAQGCPGPKPAPD 523
               A VP       AS   PR  G   P   P+
Sbjct: 1124 SRPAQVP------QASGEQPRGNGANPPGAPPE 1150


>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
           sapiens]
          Length = 735

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 61/210 (29%), Positives = 77/210 (36%), Gaps = 18/210 (8%)

Query: 339 RERRHQCQAREP--PEQLPQHRPGDPAASTSTPEPD----PADSSDFLALA-GLRAWREH 391
           +ER H  Q  EP  PE  PQ   G  A +     P+    PA  +   +L    R W   
Sbjct: 27  KERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSSPEASRSPARGAYLQSLEPSSRRWVLG 86

Query: 392 GVRPLPYRHPESQQEGAVAPWGP---RRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHL 448
           G +P           G   P G      +PEE      P+ P   P  ++E  G + Q  
Sbjct: 87  GAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDPRPPAPEPPGPQPG-SAESEGLAPQGA 145

Query: 449 VP-SPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSWGPGLG-DGVAAVPVLRALEVAS 506
            P SPP       S   + R S  ++      R L   GP  G +   A P   A  V S
Sbjct: 146 APASPPTKASRTKSPGPARRLSIKMKKLPELRRRLSLRGPRAGRERERAAP---AGSVIS 202

Query: 507 RLS-PRAQGCPGPKPAPDAAARPPRAAELS 535
           R     + G PGP   P    R PRA  LS
Sbjct: 203 RYHLDSSVGGPGPAAGP-GGTRSPRAGYLS 231



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 38/139 (27%), Positives = 52/139 (37%), Gaps = 21/139 (15%)

Query: 419 EEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGS-------SSPRWSTD 471
           +E+ H A+   PS P      P G+ +    PS P+  R    G+       SS RW   
Sbjct: 27  KERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSSPEASRSPARGAYLQSLEPSSRRWVLG 86

Query: 472 LQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKP--------APD 523
             ++      LG   PG G+    +      E   R  P A   PGP+P        AP 
Sbjct: 87  -GAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDPR--PPAPEPPGPQPGSAESEGLAPQ 143

Query: 524 AAA---RPPRAAELSHPSP 539
            AA    P +A+    P P
Sbjct: 144 GAAPASPPTKASRTKSPGP 162


>gi|40556370 PHD finger protein 15 [Homo sapiens]
          Length = 790

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 46/173 (26%), Positives = 68/173 (39%), Gaps = 11/173 (6%)

Query: 286 QSRASRPWPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQC 345
           ++ A   WP +   R  P P GLLSE+L  ++ T         +  G+P +  R R    
Sbjct: 543 ENMAMSEWPLNNGHREDPAP-GLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLP 601

Query: 346 QAREPPEQLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQ 405
             ++PP   PQ  PG    S +TP+  P  +    A +G +  +    R  P R      
Sbjct: 602 AKKKPPPPPPQDGPG----SRTTPDKAPKKTWGQDAGSG-KGGQGPPTRKPPRRTSSHLP 656

Query: 406 EGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRP 458
               A   P     E      P+TP    S+A++     S   VP P   P+P
Sbjct: 657 SSPAAGDCPILATPESPPPLAPETPDEAASVAAD-----SDVQVPGPAASPKP 704



 Score = 29.3 bits (64), Expect = 9.6
 Identities = 34/149 (22%), Positives = 49/149 (32%), Gaps = 22/149 (14%)

Query: 405 QEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSS 464
           ++ ++ P  P R    +      K P  PP       G  S+      PK    +D+GS 
Sbjct: 581 RDPSLRPGDPARKARGRTRLPAKKKPPPPPP----QDGPGSRTTPDKAPKKTWGQDAGSG 636

Query: 465 SPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQG---------- 514
                   +   RR        P  GD     P+L   E    L+P              
Sbjct: 637 KGGQGPPTRKPPRRTSSHLPSSPAAGD----CPILATPESPPPLAPETPDEAASVAADSD 692

Query: 515 --CPGP--KPAPDAAARPPRAAELSHPSP 539
              PGP   P P    RPPR ++++   P
Sbjct: 693 VQVPGPAASPKPLGRLRPPRESKVTRRLP 721


>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
            sapiens]
          Length = 1866

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/169 (29%), Positives = 73/169 (43%), Gaps = 29/169 (17%)

Query: 94   NLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADL------DGIASLPALKELYASY 147
            +L  L LN S L  L    + +  LQ L L R  + D+      + + +  +L+EL  S+
Sbjct: 1556 DLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSH 1615

Query: 148  NNISDLSPLCL------LEQLEVLDLEGNSVEDLGQVRY---LQLCPRLAMLTLEGNLVC 198
            N I D     L      L +L  +DL GNS+   G V+    L LC RL  L L  N + 
Sbjct: 1616 NQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALG 1675

Query: 199  LQPAPGPTNKVPRGYNYRAEVRKLIPQLQVLDEVPAAHTGPPAPPRLSQ 247
               A G   ++P+              L+VL  +P +H GP     L+Q
Sbjct: 1676 DPTALGLAQELPQ-------------HLRVL-HLPFSHLGPGGALSLAQ 1710


>gi|223718151 leucine rich transmembrane and 0-methyltransferase
           domain containing isoform 2 [Homo sapiens]
          Length = 158

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 9/86 (10%)

Query: 119 QVLWLARCGLADLDGIASLPA--------LKELYASYNNISDLSP-LCLLEQLEVLDLEG 169
           Q LWL    L DL     + +        L  +  S+N+++ + P L     L VL L G
Sbjct: 52  QSLWLNNNVLNDLRDFNQVASQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHG 111

Query: 170 NSVEDLGQVRYLQLCPRLAMLTLEGN 195
           NS++ LG+V  L + PRL  LTL GN
Sbjct: 112 NSIQRLGEVNKLAVLPRLRSLTLHGN 137


>gi|21687175 leucine rich transmembrane and 0-methyltransferase
           domain containing isoform 1 [Homo sapiens]
          Length = 192

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 9/86 (10%)

Query: 119 QVLWLARCGLADLDGIASLPA--------LKELYASYNNISDLSP-LCLLEQLEVLDLEG 169
           Q LWL    L DL     + +        L  +  S+N+++ + P L     L VL L G
Sbjct: 52  QSLWLNNNVLNDLRDFNQVASQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHG 111

Query: 170 NSVEDLGQVRYLQLCPRLAMLTLEGN 195
           NS++ LG+V  L + PRL  LTL GN
Sbjct: 112 NSIQRLGEVNKLAVLPRLRSLTLHGN 137


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 43/138 (31%), Positives = 59/138 (42%), Gaps = 17/138 (12%)

Query: 95  LDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNI-SDL 153
           LD  K N    G +  L     +L+ L L   GL  +  +  LP LK+L  S N I   L
Sbjct: 24  LDNCKSND---GKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGL 80

Query: 154 SPLC-LLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRG 212
             L   L  L  L+L GN ++D+  +  L+             L CL+       +V   
Sbjct: 81  DMLAEKLPNLTHLNLSGNKLKDISTLEPLK------------KLECLKSLDLFNCEVTNL 128

Query: 213 YNYRAEVRKLIPQLQVLD 230
            +YR  V KL+PQL  LD
Sbjct: 129 NDYRESVFKLLPQLTYLD 146



 Score = 30.0 bits (66), Expect = 5.6
 Identities = 38/118 (32%), Positives = 54/118 (45%), Gaps = 8/118 (6%)

Query: 80  TREGSLGNFGVHLPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGL-ADLDGIAS-L 137
           + +G +        NL+ L L    L S+ +L   L  L+ L L+   +   LD +A  L
Sbjct: 29  SNDGKIEGLTAEFVNLEFLSLINVGLISVSNL-PKLPKLKKLELSENRIFGGLDMLAEKL 87

Query: 138 PALKELYASYNNISDLS---PLCLLEQLEVLDLEGNSVEDLGQVR--YLQLCPRLAML 190
           P L  L  S N + D+S   PL  LE L+ LDL    V +L   R    +L P+L  L
Sbjct: 88  PNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYL 145


>gi|24308207 leucine rich repeat containing 47 [Homo sapiens]
          Length = 583

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 39/110 (35%), Positives = 53/110 (48%), Gaps = 8/110 (7%)

Query: 92  LPNLDQLKLNGSHLGSL-RDLGTSLGHLQVLWLARCGL----ADLDGIASLPALKELYAS 146
           LP L  L L+G+ L  L  DL      LQ L L    L    A+L    +LP L EL A+
Sbjct: 128 LPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAA 187

Query: 147 YNNISDLSP-LCLLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGN 195
            N + +LSP +  L  L+ LDL  N + ++     L  CP+L  +   GN
Sbjct: 188 DNCLRELSPDIAHLASLKTLDLSNNQLSEI--PAELADCPKLKEINFRGN 235



 Score = 30.8 bits (68), Expect = 3.3
 Identities = 51/170 (30%), Positives = 65/170 (38%), Gaps = 49/170 (28%)

Query: 92  LPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNIS 151
           LP L  L+++G   GSLR  G  L                     LP L  L    N + 
Sbjct: 49  LPLLHYLEVSGC--GSLRAPGPGLAQ------------------GLPQLHSLVLRRNALG 88

Query: 152 D-LSP-LCLLEQLEVLDLEGNSVEDLGQVRYLQLC-----PRLAMLTLEGNLVCLQPAPG 204
             LSP L  L  L VLDL GN++E L   + L        P+L  L L GN +   P   
Sbjct: 89  PGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELP--- 145

Query: 205 PTNKVPRGYNYRAEVRKLIPQLQ-------VLDEVPAAHTGPPAPPRLSQ 247
                       A++ +  P+LQ        LD  PA    P A P LS+
Sbjct: 146 ------------ADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSE 183


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 58/182 (31%), Positives = 71/182 (39%), Gaps = 31/182 (17%)

Query: 363 AASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAP-WGPRRVPEEQ 421
           AA+T+ P P PA         G RA R     PL    P      AVAP  GPRR P   
Sbjct: 154 AAATAPPSPGPAQP-------GPRAQR---AAPLAAPPPAPAAPPAVAPPAGPRRAPPPA 203

Query: 422 VHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRV 481
           V   EP  P  PP   + P     Q   P PP+   P + G+     +    S    +R 
Sbjct: 204 VAAREPPLP-PPPQPPAPP-----QQQQPPPPQPQPPPEGGAVRAGGAARPVSLREVVRY 257

Query: 482 L-GSWGPG-----------LGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAARPP 529
           L GS G G           L +  AA   L    + +   PR    PG  P P A+ARP 
Sbjct: 258 LGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGDR-PGRAP-PAASARPS 315

Query: 530 RA 531
           R+
Sbjct: 316 RS 317



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 33/132 (25%), Positives = 44/132 (33%), Gaps = 11/132 (8%)

Query: 411 PWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWST 470
           P  PR  P      A P TP+ PP  A   +         +P + PR   + +++P    
Sbjct: 112 PRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAA--------APARAPRAAAAAATAPPSPG 163

Query: 471 DLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGC-PGPKPAPDAAARPP 529
             Q   R  R      P      AA P +       R  P A      P P P     PP
Sbjct: 164 PAQPGPRAQRAAPLAAP--PPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPP 221

Query: 530 RAAELSHPSPVP 541
           +  +   P P P
Sbjct: 222 QQQQPPPPQPQP 233



 Score = 30.4 bits (67), Expect = 4.3
 Identities = 29/118 (24%), Positives = 38/118 (32%), Gaps = 8/118 (6%)

Query: 427 PKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSWG 486
           P+  ++PP+    P G  +     +PP  P P    +     +     R           
Sbjct: 102 PRRGATPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPS 161

Query: 487 PGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAAR---PPRAAELSHPSPVP 541
           PG      A P  RA   A   +P       P  AP A  R   PP  A    P P P
Sbjct: 162 PG-----PAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPP 214


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 84/323 (26%), Positives = 108/323 (33%), Gaps = 63/323 (19%)

Query: 224 PQLQVLDEVPAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLP 283
           P LQ L   PA    PP+    S     + +A       PPL  P   P  +  P L+LP
Sbjct: 349 PSLQTLPSPPAT---PPSQATTSLGSPTL-QATHSFLPSPPLS-PLATPPPQAPPALALP 403

Query: 284 ETQSRASRPW--PFSLLVRGGPLPEGLLSEDL--APEDNTSSLTHGAGQVLCGNPTKGLR 339
             Q+  S P   P S L    P     L+  L  AP     S                  
Sbjct: 404 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS------------------ 445

Query: 340 ERRHQCQAREPPEQLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYR 399
                     PP Q P   P  P  S S   P  A  S  LA   L+      V P P  
Sbjct: 446 ----------PPVQAPFSPPASPPVSPSATPPSQAPPS--LAAPPLQ------VPPSPPA 487

Query: 400 HPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPR 459
            P         P  P  +    +  A+P  P +PP+LA+ P        +PSPP      
Sbjct: 488 SPPMSPSATPPPQAPPPLAAPPLQLAKP-PPQAPPALATPP-----LQALPSPP------ 535

Query: 460 DSGSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQG-CPGP 518
              +S P  +    S    +  L +  P     V A P+L+ +  +   SP  Q     P
Sbjct: 536 ---ASFPGQAPFSPSASLPMSPLAT-PPPQAPPVLAAPLLQ-VPPSPPASPTLQAPRRPP 590

Query: 519 KPAPDAAARPPRAAELSHPSPVP 541
            P PD +   PR      P P P
Sbjct: 591 TPGPDTSVSGPRLTLALAPGPPP 613



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 58/203 (28%), Positives = 76/203 (37%), Gaps = 40/203 (19%)

Query: 348 REPPEQLPQHRP-GDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQE 406
           R PP +     P   P  ++ T  P P      L   GLR   E  V     +  E+ + 
Sbjct: 102 RAPPAKNTSPGPVSSPGRASGTTRPGP------LGQKGLRISAEETVAR--GKATEAPKR 153

Query: 407 GAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPR-----PRDS 461
            A++  G RR          P TPS   +  S  +GT      P+P   PR     PR S
Sbjct: 154 SALSA-GARR----DTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS 208

Query: 462 GSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVA-------SRLSPRAQG 514
            SS+   ST   S   R R      P  G G+   P  R+L  +       +R  P A+G
Sbjct: 209 VSSASEHSTTEPSPAARRR------PSAGGGLQR-PASRSLSSSATPLSSPARSGPSARG 261

Query: 515 CP-------GPKPAPDAAARPPR 530
            P        PKP    A RPP+
Sbjct: 262 TPRAPAHPSQPKPKGLQALRPPQ 284



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 56/220 (25%), Positives = 74/220 (33%), Gaps = 50/220 (22%)

Query: 233 PAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRP 292
           P A   P APP L+   L V  +       P L  PR  P    D  +S P         
Sbjct: 554 PLATPPPQAPPVLAAPLLQVPPSPPAS---PTLQAPRRPPTPGPDTSVSGPR-------- 602

Query: 293 WPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPE 352
              +L +  GP P         P  + SS   G    L G          H   A   PE
Sbjct: 603 --LTLALAPGPPPP--------PSRSPSSTLSGPD--LAG----------HSSSATSTPE 640

Query: 353 QLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPW 412
           +L  +  G    + ++P PD       LA     AW      PL +R       GA  PW
Sbjct: 641 ELRGYDSGPEGGAAASPPPDAE-----LAACHPAAWSRGPAPPLAFR----GAPGAPLPW 691

Query: 413 GPRRVPEE-----QVHQAEPKTPSSPPSLASEPS---GTS 444
            P   P        +++ E    ++P   A +P    GTS
Sbjct: 692 PPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTS 731



 Score = 33.1 bits (74), Expect = 0.66
 Identities = 80/322 (24%), Positives = 102/322 (31%), Gaps = 56/322 (17%)

Query: 269 RGAPIRRLDP-ELSLPETQSRASRPWPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHGAG 327
           R  P +   P  +S P   S  +RP P           E +           S+L+ GA 
Sbjct: 102 RAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGAR 161

Query: 328 QVLCGNPTKGLRE----RRHQCQAREP--PEQLPQHRPGDP----------AASTSTPEP 371
           +   G PT G       RR +    E   P   P  RP  P          A+  ST EP
Sbjct: 162 RDTSG-PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP 220

Query: 372 DPADSSDFLALAGLR--AWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKT 429
            PA      A  GL+  A R       P   P      A      R  P    H ++PK 
Sbjct: 221 SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA------RGTPRAPAHPSQPKP 274

Query: 430 PS---------SPPS---------LASEPSGTSSQHLV---PSPPKHPRPRDSGSSSPRW 468
                      +PP          L+S P  T S        +PP  P    S S + + 
Sbjct: 275 KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQL 334

Query: 469 STDLQ------SRGRRLRVLGS---WGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPK 519
           +T L       S    L+ L S     P         P L+A        P +     P 
Sbjct: 335 ATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP 394

Query: 520 PAPDAAARPPRAAELSHPSPVP 541
            AP A A PP  A  S P+  P
Sbjct: 395 QAPPALALPPLQAPPSPPASPP 416



 Score = 30.0 bits (66), Expect = 5.6
 Identities = 62/263 (23%), Positives = 87/263 (33%), Gaps = 74/263 (28%)

Query: 280 LSLPETQSRASRPWPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLR 339
           L  P ++S +S   P S   R GP   G       P                    KGL 
Sbjct: 234 LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP---------------KGL- 277

Query: 340 ERRHQCQAREPPEQLPQHRPGDPAAS--TSTPEPDPADSSDFLALAGLRAWREHGVRPLP 397
                 QA  PP+  P  +   PA    +S+P   P+ S      A L++     +   P
Sbjct: 278 ------QALRPPQVTPPRKDAAPALGPLSSSPLATPSPS------AALQSQAPPTLPATP 325

Query: 398 YRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPR 457
           +    + Q     P  P              +PS+PPSL +          +PSPP  P 
Sbjct: 326 HSSSLTCQLATPLPLAP-------------PSPSAPPSLQT----------LPSPPATPP 362

Query: 458 PRDSGS-SSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCP 516
            + + S  SP            L+   S+ P         P L  L      +P A   P
Sbjct: 363 SQATTSLGSP-----------TLQATHSFLPS--------PPLSPLATPPPQAPPALALP 403

Query: 517 GPKPAPDAAARPPRAAELSHPSP 539
            P  AP +    P  + L+ PSP
Sbjct: 404 -PLQAPPSPPASPPLSPLATPSP 425



 Score = 29.3 bits (64), Expect = 9.6
 Identities = 35/117 (29%), Positives = 44/117 (37%), Gaps = 29/117 (24%)

Query: 437 ASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSWGP--------- 487
           A  P+  +   L P PP  PRP    + +             LRVLG+ G          
Sbjct: 14  ARTPAARAPGLLTPRPPGSPRPPPPVTPA------------ALRVLGAAGAVGRKPLAER 61

Query: 488 GLGDGVAAVPVLRALEVASRLSP-RAQGCPGPKPA--PDAAARPPRAAELSHPSPVP 541
             G G A +P     E A R  P R+ G     PA  P A+ R  RA    + SP P
Sbjct: 62  AGGIGGATIP-----ESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGP 113


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 84/323 (26%), Positives = 108/323 (33%), Gaps = 63/323 (19%)

Query: 224 PQLQVLDEVPAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLP 283
           P LQ L   PA    PP+    S     + +A       PPL  P   P  +  P L+LP
Sbjct: 310 PSLQTLPSPPAT---PPSQATTSLGSPTL-QATHSFLPSPPLS-PLATPPPQAPPALALP 364

Query: 284 ETQSRASRPW--PFSLLVRGGPLPEGLLSEDL--APEDNTSSLTHGAGQVLCGNPTKGLR 339
             Q+  S P   P S L    P     L+  L  AP     S                  
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS------------------ 406

Query: 340 ERRHQCQAREPPEQLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYR 399
                     PP Q P   P  P  S S   P  A  S  LA   L+      V P P  
Sbjct: 407 ----------PPVQAPFSPPASPPVSPSATPPSQAPPS--LAAPPLQ------VPPSPPA 448

Query: 400 HPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPR 459
            P         P  P  +    +  A+P  P +PP+LA+ P        +PSPP      
Sbjct: 449 SPPMSPSATPPPQAPPPLAAPPLQLAKP-PPQAPPALATPP-----LQALPSPP------ 496

Query: 460 DSGSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQG-CPGP 518
              +S P  +    S    +  L +  P     V A P+L+ +  +   SP  Q     P
Sbjct: 497 ---ASFPGQAPFSPSASLPMSPLAT-PPPQAPPVLAAPLLQ-VPPSPPASPTLQAPRRPP 551

Query: 519 KPAPDAAARPPRAAELSHPSPVP 541
            P PD +   PR      P P P
Sbjct: 552 TPGPDTSVSGPRLTLALAPGPPP 574



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 82/335 (24%), Positives = 104/335 (31%), Gaps = 56/335 (16%)

Query: 237 TGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRPWPFS 296
           T P + PR      +   A  +G   PP       P+       S P   S  +RP P  
Sbjct: 69  TIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPV-------SSPGRASGTTRPGPLG 121

Query: 297 LLVRGGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRE----RRHQCQAREP-- 350
                    E +           S+L+ GA +   G PT G       RR +    E   
Sbjct: 122 QKGLRISAEETVARGKATEAPKRSALSAGARRDTSG-PTPGTPSPAMARRSRAAGTEVGL 180

Query: 351 PEQLPQHRPGDP----------AASTSTPEPDPADSSDFLALAGLR--AWREHGVRPLPY 398
           P   P  RP  P          A+  ST EP PA      A  GL+  A R       P 
Sbjct: 181 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 240

Query: 399 RHPESQQEGAVAPWGPRRVPEEQVHQAEPKTPS---------SPPSLASEPSG---TSSQ 446
             P      A      R  P    H ++PK            +PP   + P+    +SS 
Sbjct: 241 SSPARSGPSA------RGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 294

Query: 447 HLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVAS 506
              PSP   P P    S     S       +    LGS            P L+A     
Sbjct: 295 LATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGS------------PTLQATHSFL 342

Query: 507 RLSPRAQGCPGPKPAPDAAARPPRAAELSHPSPVP 541
              P +     P  AP A A PP  A  S P+  P
Sbjct: 343 PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP 377



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 56/220 (25%), Positives = 74/220 (33%), Gaps = 50/220 (22%)

Query: 233 PAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRP 292
           P A   P APP L+   L V  +       P L  PR  P    D  +S P         
Sbjct: 515 PLATPPPQAPPVLAAPLLQVPPSPPAS---PTLQAPRRPPTPGPDTSVSGPR-------- 563

Query: 293 WPFSLLVRGGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPE 352
              +L +  GP P         P  + SS   G    L G          H   A   PE
Sbjct: 564 --LTLALAPGPPPP--------PSRSPSSTLSGPD--LAG----------HSSSATSTPE 601

Query: 353 QLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPW 412
           +L  +  G    + ++P PD       LA     AW      PL +R       GA  PW
Sbjct: 602 ELRGYDSGPEGGAAASPPPDAE-----LAACHPAAWSRGPAPPLAFR----GAPGAPLPW 652

Query: 413 GPRRVPEE-----QVHQAEPKTPSSPPSLASEPS---GTS 444
            P   P        +++ E    ++P   A +P    GTS
Sbjct: 653 PPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTS 692



 Score = 30.0 bits (66), Expect = 5.6
 Identities = 47/181 (25%), Positives = 63/181 (34%), Gaps = 47/181 (25%)

Query: 360 GDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPE 419
           G P A     +P P          GL+A R   V P     P      A+ P      P 
Sbjct: 252 GTPRAPAHPSQPKPK---------GLQALRPPQVTP-----PRKDAAPALGPLSSS--PL 295

Query: 420 EQVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGS-SSPRWSTDLQSRGRR 478
                + P +PS+PPSL +          +PSPP  P  + + S  SP            
Sbjct: 296 ATPSPSAPPSPSAPPSLQT----------LPSPPATPPSQATTSLGSP-----------T 334

Query: 479 LRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAARPPRAAELSHPS 538
           L+   S+ P         P L  L      +P A   P P  AP +    P  + L+ PS
Sbjct: 335 LQATHSFLPS--------PPLSPLATPPPQAPPALALP-PLQAPPSPPASPPLSPLATPS 385

Query: 539 P 539
           P
Sbjct: 386 P 386


>gi|238859651 pleckstrin homology domain containing family A member
           4 isoform 1 [Homo sapiens]
          Length = 779

 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 51/175 (29%), Positives = 66/175 (37%), Gaps = 36/175 (20%)

Query: 306 EGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRHQCQAREPPEQLPQHRPGDPAAS 365
           EG +SE  +PE    S   G  ++L  +PT  L       +AR P    P  RP  P   
Sbjct: 188 EGRISE--SPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPL-- 243

Query: 366 TSTPEP-------DPADSSDF---------LALAGLRAWREHGVR-------PLPYRHPE 402
            S P P        PA S D          L+   +R   + G +       P P R P 
Sbjct: 244 -SLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPP 302

Query: 403 SQQEGAVAPWGPR---RVPEEQVHQAEPKTPSSPPSLASEPSGT-SSQHLVPSPP 453
           S+  G   P  P+   + P  Q H   P     PP     P GT +S  L+P PP
Sbjct: 303 SEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPP----RPPGTRASMVLLPGPP 353


>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
           sapiens]
          Length = 757

 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 36/109 (33%), Positives = 55/109 (50%), Gaps = 6/109 (5%)

Query: 91  HLPNLDQLKLNGSHLGSLRDLG-TSLGHLQVLWLARCGLADL--DGIASLPALKELYASY 147
           H+P L  L L G+H+ +LR+L   S  +L VL + +  +  L  +  A L  L EL    
Sbjct: 245 HMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGS 304

Query: 148 NNISDLSPLCL--LEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEG 194
           N I +L PL    L++L  L+L  N ++ + Q        +L  L+LEG
Sbjct: 305 NKIENLPPLIFKDLKELSQLNLSYNPIQKI-QANQFDYLVKLKSLSLEG 352


>gi|117414154 sodium channel associated protein 2 isoform b [Homo
           sapiens]
          Length = 939

 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 11/102 (10%)

Query: 133 GIASLPALKELYASYNNISDLSPLCLLE----QLEVLDLEGNSVEDLGQVRYLQLCPRLA 188
           G+  L  L  L  SYN+I DLS L  L     +L  +DL  N ++ +  +  LQ    L 
Sbjct: 11  GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHL--LQCMVGLH 68

Query: 189 MLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQLQVLD 230
            LT   NL+  +   G  N V R   YRA + + +PQL++LD
Sbjct: 69  FLT---NLILEKD--GDDNPVCRLPGYRAVILQTLPQLRILD 105


>gi|171543895 ataxin 2 [Homo sapiens]
          Length = 1313

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 49/176 (27%), Positives = 64/176 (36%), Gaps = 13/176 (7%)

Query: 362 PAASTS-TPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPWGPRRVPEE 420
           P+ STS T + +P   SD   + G   W      P P   P S+ +      GP  +P  
Sbjct: 525 PSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPC--PSPSSRPPSRYQS-----GPNSLPPR 577

Query: 421 QVHQAEPKTPSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSGSSSPRWSTDLQSRGRRLR 480
                 P  PS PPS  S P    S H  P+P      R S    PR S   Q   R  R
Sbjct: 578 AATPTRP--PSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHR 635

Query: 481 VLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQGCPGPKPAPDAAARPPRAAELSH 536
           V    G  +  G+  V      E A+   P A+  P         +  PR +  +H
Sbjct: 636 VSAGRG-SISSGLEFVSHNPPSEAAT--PPVARTSPSGGTWSSVVSGVPRLSPKTH 688


>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
           sapiens]
          Length = 360

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/134 (25%), Positives = 70/134 (52%), Gaps = 3/134 (2%)

Query: 48  QLVEEYLSPARLQALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQLKLNGSHLGS 107
           +L + +L   ++  +  + +L  ++ LE+    R  ++ N    L NL+ L L  + +  
Sbjct: 165 RLKKLFLVNNKISKIENLSNLHQLQMLELG-SNRIRAIENIDT-LTNLESLFLGKNKITK 222

Query: 108 LRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLEVLDL 167
           L++L  +L +L VL +    L  ++G+ +L  L+ELY S+N I  +  L    +L +LD+
Sbjct: 223 LQNLD-ALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDI 281

Query: 168 EGNSVEDLGQVRYL 181
             N ++ +  + +L
Sbjct: 282 ASNRIKKIENISHL 295



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/119 (26%), Positives = 60/119 (50%), Gaps = 9/119 (7%)

Query: 60  QALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQLKLNGSHLGSLRDLGTSLGHLQ 119
           + L +V  L L + L  C++  E         L +L +L L  + +  + +L  +L  L+
Sbjct: 95  EVLKKVKTLCLRQNLIKCIENLE--------ELQSLRELDLYDNQIKKIENL-EALTELE 145

Query: 120 VLWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQV 178
           +L ++   L +++G+  L  LK+L+   N IS +  L  L QL++L+L  N +  +  +
Sbjct: 146 ILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENI 204


>gi|31324577 molecule interacting with Rab13 [Homo sapiens]
          Length = 863

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 91/389 (23%), Positives = 138/389 (35%), Gaps = 72/389 (18%)

Query: 201 PAPGPTNKVPRGYNYRA-----EVRKLIP-------QLQVLDEVPAAHTGP--------- 239
           P  GP++  P G          E R  IP       +LQ L   PA    P         
Sbjct: 253 PGGGPSSSAPAGAEADGPKASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKASEST 312

Query: 240 -PAPPR------LSQDWLAVKEAIKKG--NGLP---PLDCPRGAPIRRLDPELSLPETQS 287
            PAPP       L Q+ L V++A      NG     P+  PRG P     P    P    
Sbjct: 313 TPAPPTPRPRSSLQQENL-VEQAGSSSLVNGRLHELPVPKPRGTP----KPSEGTPAP-- 365

Query: 288 RASRPWPFSLLV----RGGPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGNPTKGLRERRH 343
           R   PW   +      +  PLP    S     +D+      G  +V   +PT  L  + +
Sbjct: 366 RKDPPWITLVQAEPKKKPAPLPPSS-SPGPPSQDSRQVENGGTEEVAQPSPTASLESKPY 424

Query: 344 QCQAREPPEQLPQHRPGDPAASTSTPEPDPADSSDFLALAGLRAWREHGVRPLPYRHPES 403
                E  E   +  P  P+ +TS     P  +        L  W  +G+ P      + 
Sbjct: 425 N-PFEEEEEDKEEEAPAAPSLATSPALGHPESTPK-----SLHPW--YGITPTSSPKTKK 476

Query: 404 QQEGAVAPWGPRRVPEEQVHQAEPKTPSSPP-----SLASEPSGTSSQHLVPSPPKHPR- 457
           +         P  +   ++  +EP + +  P     SL+SE +  ++   +  PP  P+ 
Sbjct: 477 RPAPRAPSASPLALHASRLSHSEPPSATPSPALSVESLSSESASQTAGAELLEPPAVPKS 536

Query: 458 ---PRDSGSSSPRWSTDLQSRGRRLRVLGSWGPGLGDGVAAVPVLRALEVASRLSPRAQG 514
              P      +P     L +       L S G  +   V  +P     + +  L+PR +G
Sbjct: 537 SSEPAVHAPGTPGNPVSLSTNSS----LASSGELVEPRVEQMP-----QASPGLAPRTRG 587

Query: 515 CPGPKPA-PDAAARPPRAAELSHPSPVPT 542
             GP+PA P + A P     +   SPVP+
Sbjct: 588 SSGPQPAKPCSGATPTPLLLVGDRSPVPS 616


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.135    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,030,307
Number of Sequences: 37866
Number of extensions: 1745223
Number of successful extensions: 10694
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 717
Number of HSP's that attempted gapping in prelim test: 8510
Number of HSP's gapped (non-prelim): 2451
length of query: 542
length of database: 18,247,518
effective HSP length: 107
effective length of query: 435
effective length of database: 14,195,856
effective search space: 6175197360
effective search space used: 6175197360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.