Search of human proteins with 38492356

Search of human proteins with 38492356

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38492356 DNA-directed DNA polymerase delta 3 [Homo sapiens]
         (466 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38492356 DNA-directed DNA polymerase delta 3 [Homo sapiens]        921   0.0  
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    56   6e-08
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora...    54   4e-07
gi|148613878 acrosin precursor [Homo sapiens]                          53   5e-07
gi|169163027 PREDICTED: similar to Putative acrosin-like proteas...    52   9e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     51   3e-06
gi|31543452 PX domain containing serine/threonine kinase [Homo s...    48   2e-05
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    47   4e-05
gi|210032580 SET domain containing 1B [Homo sapiens]                   47   4e-05
gi|125656165 THO complex 2 [Homo sapiens]                              46   8e-05
gi|104526627 triadin [Homo sapiens]                                    45   1e-04
gi|148806928 hypothetical protein LOC57482 [Homo sapiens]              44   3e-04
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    44   4e-04
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    44   4e-04
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    44   4e-04
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [...    43   5e-04
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    43   5e-04
gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s...    43   7e-04
gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s...    43   7e-04
gi|4557719 DNA ligase I [Homo sapiens]                                 42   0.001
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    42   0.001
gi|158534059 formin binding protein 4 [Homo sapiens]                   42   0.001
gi|58761544 amine oxidase (flavin containing) domain 2 isoform a...    42   0.001
gi|58761546 amine oxidase (flavin containing) domain 2 isoform b...    42   0.001
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...    42   0.002
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    42   0.002
gi|38788260 bromodomain PHD finger transcription factor isoform ...    42   0.002
gi|38788274 bromodomain PHD finger transcription factor isoform ...    42   0.002
gi|158420731 chromodomain helicase DNA binding protein 3 isoform...    42   0.002
gi|110349719 titin isoform N2-A [Homo sapiens]                         41   0.002

>gi|38492356 DNA-directed DNA polymerase delta 3 [Homo sapiens]
          Length = 466

 Score =  921 bits (2381), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVT 60
           MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVT
Sbjct: 1   MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVT 60

Query: 61  YLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYD 120
           YLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYD
Sbjct: 61  YLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYD 120

Query: 121 ILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP 180
           ILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP
Sbjct: 121 ILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP 180

Query: 181 ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFG 240
           ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFG
Sbjct: 181 ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFG 240

Query: 241 KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR 300
           KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR
Sbjct: 241 KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR 300

Query: 301 GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE 360
           GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE
Sbjct: 301 GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE 360

Query: 361 PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMK 420
           PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMK
Sbjct: 361 PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMK 420

Query: 421 TSSVHRPPAMTVKKEPREERKGPKKGTAALGKANRQVSITGFFQRK 466
           TSSVHRPPAMTVKKEPREERKGPKKGTAALGKANRQVSITGFFQRK
Sbjct: 421 TSSVHRPPAMTVKKEPREERKGPKKGTAALGKANRQVSITGFFQRK 466


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 77/363 (21%), Positives = 130/363 (35%), Gaps = 51/363 (14%)

Query: 138 AAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFA 197
           AA  P   A+SS S            ++      +T         K     PK   G   
Sbjct: 156 AAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANG--- 212

Query: 198 SKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAV 257
            KAA+ +  ++  + ++  E   A+A   K   K  +++    KAA    + +  SE + 
Sbjct: 213 -KAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS 271

Query: 258 KEEKIVEQ--------PTVSVTEPKLATPAGL------KKSSKKAEPVKVLQ-------- 295
            +E+  ++        P  SV  P    P         KK+ +K +PV+  +        
Sbjct: 272 SDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDS 331

Query: 296 ---KEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPP 352
              +EKK   +  +S   TK     +         +SDSSED+  P  P      S + P
Sbjct: 332 SSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKP 391

Query: 353 ---------PPPSPPLEPV--------PKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDG 395
                     P + P +PV         K +      +SSS E ++ +K V  +K     
Sbjct: 392 AVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATA 451

Query: 396 EGCIVTEKVYESESCTDSEEELNMKTS--SVHRPPAMTVKKEPREERKG---PKKGTAAL 450
           +  +        +   DS  + +  +S     +     VKK+P++   G    K  +A  
Sbjct: 452 KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKK 511

Query: 451 GKA 453
           GKA
Sbjct: 512 GKA 514



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 45/212 (21%), Positives = 83/212 (39%), Gaps = 25/212 (11%)

Query: 139 AAVPRAP-----------AESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQ 187
           AA P+ P           A+SSSS ++   S    + +  A  +          S    Q
Sbjct: 403 AAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAA-LSLPAKQ 461

Query: 188 QPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKF 247
            P+G     +   ++ ++E  ++T   A +      AG  AP K        GKA  +  
Sbjct: 462 APQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKK--GKAESSNS 519

Query: 248 KVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALS 307
             + DS +  +EEK+  + +     PK    + L   + KA      ++E+K+   V +S
Sbjct: 520 SSSDDSSEE-EEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVS 578

Query: 308 ----------DDETKETENMRKKRRRIKLPES 329
                     ++  KE E  + K+ +++ P +
Sbjct: 579 KSGSLKKRKQNEAAKEAETPQAKKIKLQTPNT 610



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 38/181 (20%), Positives = 70/181 (38%), Gaps = 6/181 (3%)

Query: 144 APAESSSSSK-KFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFASKAAA 202
           AP++ +S+ K K E S+   S ++    E    G G P  +         +     KAA 
Sbjct: 502 APSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAK 561

Query: 203 KTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDS--EQAVKEE 260
            ++E  +E K  A  V   S +G+    K N  +         K K+   +   +  K E
Sbjct: 562 NSEEEEEEKKKAAVVV---SKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGE 618

Query: 261 KIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKK 320
           K    P   V E ++   + +  +S  A+        ++  + +  +  ++   E  +KK
Sbjct: 619 KRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKK 678

Query: 321 R 321
           R
Sbjct: 679 R 679


>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 1 [Homo sapiens]
          Length = 559

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 271 TEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRR---IKLP 327
           T+P   +    K+SSK ++P KV ++ ++R ++ + S   +KE E  + K  +    KL 
Sbjct: 175 TKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLG 234

Query: 328 ESDSSEDEVFPDSPGAY------------EAESPSPPPPPSPPLEPVPKTEPEPPSVKSS 375
           E    ++E  P    A+            E+ SP   PPP PP  P P+   + P+   S
Sbjct: 235 EGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPP--PPPRASSKRPATADS 292

Query: 376 SGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKE 435
              + +K+K+   SK      G   + +   S S +D +     K  S  R   +  + E
Sbjct: 293 PKPSAKKQKK-SSSKGSRSAPG--TSPRTSSSSSFSDKKP---AKDKSSTRGEKVKAESE 346

Query: 436 PREERK 441
           PRE +K
Sbjct: 347 PREAKK 352



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 72/293 (24%), Positives = 112/293 (38%), Gaps = 48/293 (16%)

Query: 142 PRAPAESSSSSKKFEQSHLHMSSETQ---ANNELTTNGHGPP-------------ASKQV 185
           PR  +ES SSSK+ E+     S +T        L      PP              +K  
Sbjct: 205 PRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLE 264

Query: 186 SQQPKG---IMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNK-APGKG--NMMSNFF 239
           S  PKG          +A++K   T    K  AK+   +S+ G++ APG       S+ F
Sbjct: 265 STSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSF 324

Query: 240 GKAAMNKFKVNLDSEQAVKEEKIVE-QPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEK 298
                 K K +   E+   E +  E +  + V E      A  K  S ++ P        
Sbjct: 325 SDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSP------SN 378

Query: 299 KRGKRVALSDDETKETEN-----MRKKRRRIKLPESD-----SSEDEVFPDSPGA----- 343
                 + SD + + ++N     +R     ++  ESD     S E+     +PG      
Sbjct: 379 SSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLS 438

Query: 344 -YEAESPSPPPPPSPPLEPVPKTEPEPPSVKSS---SGENKRKRKRVLKSKTY 392
             ++ES +      P  EP P  +P PP+ K S   S E+  K +++LK  TY
Sbjct: 439 FSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTY 491


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 30/68 (44%), Positives = 35/68 (51%), Gaps = 9/68 (13%)

Query: 338 PDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSS-----GENKRKRKR----VLK 388
           P  P A     PSPPPPP PP  P+P   P PP   SS+     G +  KR +    VLK
Sbjct: 337 PRPPAAQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLK 396

Query: 389 SKTYLDGE 396
            KTY DG+
Sbjct: 397 GKTYSDGK 404


>gi|169163027 PREDICTED: similar to Putative acrosin-like protease
           [Homo sapiens]
          Length = 355

 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 30/68 (44%), Positives = 35/68 (51%), Gaps = 9/68 (13%)

Query: 338 PDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSS-----GENKRKRKR----VLK 388
           P  P A     PSPPPPP PP  P+P   P PP   SS+     G +  KR +    VLK
Sbjct: 271 PRPPAAQPRPPPSPPPPPPPPPSPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLK 330

Query: 389 SKTYLDGE 396
            KTY DG+
Sbjct: 331 GKTYSDGK 338


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 75/313 (23%), Positives = 120/313 (38%), Gaps = 37/313 (11%)

Query: 143 RAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFASKAAA 202
           ++PAE+ S  K+  +S   + S  +A +        PP +K   ++         +K+ A
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE--------EAKSPA 576

Query: 203 KTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEE-- 260
           + +   K  K+ AKE    S A  K+P K              + K   +++  VKEE  
Sbjct: 577 EVKSPEK-AKSPAKEEAK-SPAEAKSPEKAK-------SPVKEEAKSPAEAKSPVKEEAK 627

Query: 261 --KIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKE-TENM 317
               V+ P  + +  K    +  K  S + E  K  +K K   K  A S ++ K   +  
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687

Query: 318 RKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSG 377
            K   + K P  + ++      SP   EA+SP     P       P+    P   ++ S 
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP 747

Query: 378 ENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPR 437
           E   K K   K+KT LD         V   E+ T ++EE               VK+E +
Sbjct: 748 E---KAKSPEKAKT-LD---------VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794

Query: 438 --EERKGPKKGTA 448
             E+ K P K  A
Sbjct: 795 SPEKAKSPLKEDA 807



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 74/326 (22%), Positives = 124/326 (38%), Gaps = 30/326 (9%)

Query: 143 RAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFAS--KA 200
           ++PAE+ S  K+  +S   + S  +A +        P  +K   ++         S  KA
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672

Query: 201 AAKTQETNKE-TKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNK-FKVNLDSEQAVK 258
            AK+ E  K   K EAK    A     K+P K    S    K+ + +  K    ++  VK
Sbjct: 673 EAKSPEKAKSPVKAEAKSPEKA-----KSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK 727

Query: 259 EEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMR 318
           EE    +   S  + +  +P   K S +KA+ + V   E K   +        K  E  +
Sbjct: 728 EEAKTPEKAKSPVKEEAKSPEKAK-SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAK 786

Query: 319 KK-RRRIKLPESDSS---EDEVFPD----------SPGAYEAESPSPPPPPSPPLEPVPK 364
              +  +K PE   S   ED   P+          SP   E E P       PP +   +
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP-VKEEEKPQEVKVKEPPKKAEEE 845

Query: 365 TEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESE---SCTDSEEELNMKT 421
             P  P  +      K +  +    K  ++ +     EK  ES+      ++E++  + T
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905

Query: 422 SSVHRPPAMTVKKE--PREERKGPKK 445
                P  + VK++  P+E+ +  KK
Sbjct: 906 PEKEAPAKVEVKEDAKPKEKTEVAKK 931



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 58/262 (22%), Positives = 93/262 (35%), Gaps = 27/262 (10%)

Query: 204 TQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIV 263
           T+E  +E + EAKE       G +               A        +++  VKEE   
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS 526

Query: 264 EQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKE----KKRGKRVALSDDETKETENMR- 318
                S  + +  +PA +K   K   P K   K     K   K  A S  E K  E  + 
Sbjct: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS 586

Query: 319 ------------KKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTE 366
                       K   + K P  + ++      SP   EA+SP+    P     P   T+
Sbjct: 587 PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP---TK 643

Query: 367 PEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHR 426
            E  S + +    K + K   K+K+ +  E     +   +++S   +E +   K  S  +
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAE----AKSPEKAKSPVKAEAKSPEKAKSPVK 699

Query: 427 PPAMT---VKKEPREERKGPKK 445
             A +    K   +EE K P+K
Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEK 721



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 40/168 (23%), Positives = 65/168 (38%), Gaps = 11/168 (6%)

Query: 286 KKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYE 345
           K  E +KV++K +K    V    +ET+ TE + ++  +    E    E+    +     E
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498

Query: 346 AESPSPP-----PPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVL---KSKTYLDGEG 397
            E+ SPP      P      PV +    P   KS   E  +    V    K+K+    E 
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558

Query: 398 CIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPREERKGPKK 445
               E   +S    +++    +K+    + PA    K P  E K P+K
Sbjct: 559 KSPPEA--KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP-AEAKSPEK 603



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 52/207 (25%), Positives = 72/207 (34%), Gaps = 34/207 (16%)

Query: 198  SKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAV 257
            +KA  K     +E K+  KE         K P K         KA   K      +E+  
Sbjct: 807  AKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK---------KAEEEKAPATPKTEEK- 856

Query: 258  KEEKIVEQPTVSVTEPKL---ATPAGLKKSSKKAEPVKVLQKEKKR---------GKRVA 305
            K+ K  E P     +PK+     PA  K    K E  K   ++KK+          K   
Sbjct: 857  KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV 916

Query: 306  LSDDETKETENMRKKR---RRIKLPESDSSEDEVFPDSPGAYE--AESPSPPPPPSPPLE 360
              D + KE   + KK     + K P   + + E  P+     E  A+ P   P      +
Sbjct: 917  KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976

Query: 361  PVPKT---EPEPPSV----KSSSGENK 380
               KT   EP  P      KSSS + K
Sbjct: 977  EDDKTLSKEPSKPKAEKAEKSSSTDQK 1003



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 35/141 (24%), Positives = 55/141 (39%), Gaps = 13/141 (9%)

Query: 200  AAAKTQETNKETKTE-AKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVK 258
            A  K +E+  E K E A++         +AP K  +  +   K      K   D  +A +
Sbjct: 881  AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940

Query: 259  EEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMR 318
              K  E+        K A P   KK +K+ +  K  +K K   K  A  DD+T   E  +
Sbjct: 941  PSKPAEK--------KEAAPE--KKDTKEEKAKKPEEKPKTEAK--AKEDDKTLSKEPSK 988

Query: 319  KKRRRIKLPESDSSEDEVFPD 339
             K  + +   S   +D   P+
Sbjct: 989  PKAEKAEKSSSTDQKDSKPPE 1009


>gi|31543452 PX domain containing serine/threonine kinase [Homo
           sapiens]
          Length = 578

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 40/154 (25%), Positives = 64/154 (41%), Gaps = 16/154 (10%)

Query: 246 KFKVNLDSEQAVK------EEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKK 299
           +FK+    ++A++      E++++E+        +L        S ++ +  K+L +  K
Sbjct: 408 QFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILAR--K 465

Query: 300 RGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAES----PSPPPPP 355
           + KR AL + E    E+  K         S +S     P SP           P PPPPP
Sbjct: 466 KSKRSALENSE----EHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTSGISALPPPPPPP 521

Query: 356 SPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKS 389
            PP  P+P    E P+  SS   N   R  +L S
Sbjct: 522 PPPAAPLPPASTEAPAQLSSQAVNGMSRGALLSS 555


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
           sapiens]
          Length = 2462

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 79/359 (22%), Positives = 137/359 (38%), Gaps = 60/359 (16%)

Query: 116 NTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTN 175
           N   D+LK    + S     +  A   +    ++S  ++  +    M++E  +   +T  
Sbjct: 540 NDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQ 599

Query: 176 GHGPPASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASA--AGNKAPGKGN 233
                AS ++++         +S+   +  ET K+   E     +A A   G+K   +  
Sbjct: 600 QSAELASMELNE---------SSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQ-- 648

Query: 234 MMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKV 293
              NF+      K + NLD  + +++ K+  +   +    K   PA    +S++A    V
Sbjct: 649 -CKNFYFNY---KKRQNLD--EILQQHKLKMEKERNARRKKKKAPAA---ASEEAAFPPV 699

Query: 294 LQKEKKRGKRVALSDDETKE----TENMRKKRRRIKLPESDSSED--EVFPDSPGAYEAE 347
           ++ E+     V+ +++E  E    T N       I  P +++++D  +  P  P    A+
Sbjct: 700 VEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGAD 759

Query: 348 SPSPPPPPSP------PLEPVPKTE----PEPPSVKSSSG------ENKRKRKRVLKSKT 391
            P P PP  P      P EP P +E    P PP    S          + K +    +  
Sbjct: 760 GPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPP 819

Query: 392 YLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPREE-RKGPKKGTAA 449
             +GE           E    + EEL + T     P    VK E  EE  +GP KG  A
Sbjct: 820 VEEGE-----------EQKPPAAEELAVDTGKAEEP----VKSECTEEAEEGPAKGKDA 863



 Score = 29.3 bits (64), Expect = 8.0
 Identities = 26/95 (27%), Positives = 36/95 (37%), Gaps = 4/95 (4%)

Query: 347 ESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYE 406
           E  + PP P  P+ P P        V+    EN   RK+   +   L+G G  V   +Y 
Sbjct: 202 EEAAKPPEPEKPVSPPPIESKHRSLVQIIYDEN---RKKAEAAHRILEGLGPQVELPLYN 258

Query: 407 SESCTDSEEELNMKTSSVHRPPAMTVKKEPREERK 441
             S T    E N+K +   R   +   K     RK
Sbjct: 259 QPSDTRQYHE-NIKINQAMRKKLILYFKRRNHARK 292


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 57/233 (24%), Positives = 96/233 (41%), Gaps = 39/233 (16%)

Query: 140  AVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFASK 199
            ++  + AE++SSS+  E S    SSE+             P+S +  ++           
Sbjct: 1101 SIVTSKAEATSSSESSESSEFESSSESS------------PSSSEDEEE----------- 1137

Query: 200  AAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKF----KVNLDSEQ 255
              A+ +E  +E +    E + ASA        G   +   G  A++      +V++++E 
Sbjct: 1138 VVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEA 1197

Query: 256  AVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETE 315
               EE+    P++ + EP L  P G+++ +   EP +     ++ G  +   +   KE E
Sbjct: 1198 VAPEER----PSM-LDEPPL--PVGVEEPADSREPPEEPGLSQE-GAMLLSPEPPAKEVE 1249

Query: 316  NMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPE 368
              R      + PE D    EV P+ P         P PPP PP  P P  EPE
Sbjct: 1250 -ARPPLSPERAPEHDL---EVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPE 1298



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 14/33 (42%), Positives = 14/33 (42%)

Query: 338 PDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPP 370
           P  PG      P PPPPP P     P   P PP
Sbjct: 682 PPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPP 714



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 23/85 (27%), Positives = 33/85 (38%), Gaps = 16/85 (18%)

Query: 292 KVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAES--- 348
           K+ + ++  G+ + +SDDE               +  +D  +  V      A  A S   
Sbjct: 627 KMDEGQQSSGEDMEISDDEMPSAP----------ITSADCPKPMVVTPGAAAVAAPSVLA 676

Query: 349 ---PSPPPPPSPPLEPVPKTEPEPP 370
              P PPPP  PPL P P   P  P
Sbjct: 677 PTLPLPPPPGFPPLPPPPPPPPPQP 701



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 15/33 (45%), Positives = 16/33 (48%), Gaps = 1/33 (3%)

Query: 338 PDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPP 370
           P  PG +    P PPPPP PP      T P PP
Sbjct: 698 PPQPG-FPMPPPLPPPPPPPPPAHPAVTVPPPP 729



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 4/33 (12%)

Query: 350 SPPPPPSPPLEPV----PKTEPEPPSVKSSSGE 378
           +P PPP PP EP+    P T P PP   ++S E
Sbjct: 431 APAPPPLPPAEPLAKEKPGTPPGPPPPDTNSME 463



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%)

Query: 338 PDSPGAYEAESPSPPPPPSPP-LEPVPKTEPEPP 370
           P  P A+ A +  PPP P+PP + P P   P PP
Sbjct: 714 PPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPP 747


>gi|125656165 THO complex 2 [Homo sapiens]
          Length = 1593

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/290 (23%), Positives = 118/290 (40%), Gaps = 50/290 (17%)

Query: 179  PPASKQVSQQ--PKGIMGMFASKAAAKTQETNKETKTEAKEVTNASA-AGNKAPG---KG 232
            PP +   S Q  P G     +  +A+K+ E++ E   +++E +     A NKA     KG
Sbjct: 1192 PPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKG 1251

Query: 233  NMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVT------------EPKLATPAG 280
            N  +   G  +    K N D E+  ++EK  ++ T + T            +PK   P  
Sbjct: 1252 NSSNGNSGSNSNKAVKEN-DKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNK 1310

Query: 281  LKKSSKKAEPVKVLQKEKKRGKRVALSDDETKET--ENMRKKRRRIKLPESDSSEDEVFP 338
             +K+ +  E      KEK++ K+   + DE  +T   N   K  + +  E + S +    
Sbjct: 1311 DEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIA 1370

Query: 339  DSPGAYEAESPSPPPPPSPPLE-PVPKTE-PEPPSVKSSSGENKRKRKRVLKSKTYLDGE 396
                + E        P S  L+ PVP+++ PEP        E ++KR+++    +     
Sbjct: 1371 KEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEP--------EREQKRRKIDTHPS----- 1417

Query: 397  GCIVTEKVYESESCTDSEEELNMKTSSV-----HRPPAMTVKKEPREERK 441
                      S S T  +  + +K SS      H PP ++  KE   ++K
Sbjct: 1418 ---------PSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKK 1458


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/202 (23%), Positives = 76/202 (37%), Gaps = 42/202 (20%)

Query: 282 KKSSKKAEP-VKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDS 340
           +K  KK +P  K L KE+K+ K    S+++TK+ E    K+ ++K   +   E +  P  
Sbjct: 188 EKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKK-EVKGGKQEKVKQTAAKVKEVQKTPSK 246

Query: 341 PGAYEAESP-------------------------------SPPPPPSPPLEPVPKTEPEP 369
           P   E +                                 SP  PP  P E   +  P  
Sbjct: 247 PKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS 306

Query: 370 PSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHR--- 426
           P+++   GE K+  K+V       + E     +K  E E+  D E++   K S   +   
Sbjct: 307 PALEEKEGEKKKAEKKVTSETKKKEKED---IKKKSEKETAIDVEKKEPGKASETKQGTV 363

Query: 427 ---PPAMTVKKEPREERKGPKK 445
                A   K E +E+ K  KK
Sbjct: 364 KIAAQAAAKKDEKKEDSKKTKK 385



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 79/342 (23%), Positives = 127/342 (37%), Gaps = 67/342 (19%)

Query: 143 RAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGIMGMFASKAAA 202
           +A  + +S +KK E+  +   SE +   ++     G     + S+  +G + + A++AAA
Sbjct: 318 KAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPG-----KASETKQGTVKI-AAQAAA 371

Query: 203 KTQETNKETKTEAKEVTNASAAGNKA--------PGKGNMMSNFFGKAAMNKFKVNLDSE 254
           K  E  +++K   K        G K         P K     +        K K     E
Sbjct: 372 KKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKE 431

Query: 255 Q--AVKEEKIV----EQPTVSVTEPKLATPAGLKKSS--KKAEPVKVLQKEKKRGKRVAL 306
           +  AV  +K V    E+ T    E ++      K SS  K  EP+K   KE+K    +  
Sbjct: 432 EIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIK--GKEEKVPASLKE 489

Query: 307 SDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTE 366
            + ETK+ E M K  + +K                            P  P L+   + +
Sbjct: 490 KEPETKKDEKMSKAGKEVK----------------------------PKPPQLQGKKEEK 521

Query: 367 PEPPSVKS-----SSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKT 421
           PEP   K      S      K+  V   KT   G+     EKV +       E+    K 
Sbjct: 522 PEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGK---PEEKVLKQVKAVTIEKTAKPKP 578

Query: 422 S--SVHR---PPAMTVKKEPREERKGPKKGTAALGKANRQVS 458
           +  + HR   PP++   K P+   KG  + T + GK   ++S
Sbjct: 579 TKKAEHREREPPSIKTDK-PKPTPKGTSEVTES-GKKKTEIS 618



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 71/323 (21%), Positives = 121/323 (37%), Gaps = 56/323 (17%)

Query: 180 PASKQVSQQPKGIMGMFASKAAAKTQE-TNKETKTEAKEVTNASAAG----NKAPGKGNM 234
           P +K ++++ K       +K A K++E T KE K   +E    +AA      K P K   
Sbjct: 196 PETKTLAKEQK------KAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKE 249

Query: 235 MSNFFGKAAMNKFK---------------VNLDSEQAVKEEKIVEQPTVSVTEPKLATPA 279
             +   KAA++K +               V+ D +           PT   + P  A+PA
Sbjct: 250 KEDK-EKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPA 308

Query: 280 GLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPES---------- 329
             +K  +K +  K +  E K+ ++  +     KET    +K+   K  E+          
Sbjct: 309 LEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQ 368

Query: 330 ------DSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPV--PKTEPEPPSVKSSSGENKR 381
                 +  ED      P   E             +EP   PK E   PS K    + +R
Sbjct: 369 AAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTER 428

Query: 382 KRKRV--LKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPR-- 437
            ++ +  +  K  + G+    T K  E E      +E + KTSS+ +       KE +  
Sbjct: 429 AKEEIGAVSIKKAVPGKKEEKTTKTVEQE----IRKEKSGKTSSILKDKEPIKGKEEKVP 484

Query: 438 ---EERKGPKKGTAALGKANRQV 457
              +E++   K    + KA ++V
Sbjct: 485 ASLKEKEPETKKDEKMSKAGKEV 507


>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
          Length = 1233

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 65/284 (22%), Positives = 109/284 (38%), Gaps = 43/284 (15%)

Query: 205  QETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVE 264
            Q+  ++ K       +++ AG  A G         G A  +   +  + +QA    +   
Sbjct: 862  QQAEQKKKKRHSSTGDSADAGPPAAGSARGEKEMEGVALKHGPSLPQERKQAPSTRRDSA 921

Query: 265  QPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR-GKRVALSDDETKETE-----NMR 318
            +P+ S + P +A P     SS+   P       K    ++ AL+   T +T      +  
Sbjct: 922  EPSSSRSVP-VAHPGPPPASSQTPAPEHDKAANKMPLAQKPALAPKPTSQTPPASPLSKL 980

Query: 319  KKRRRIKLPESDSSEDEVFPDSPGAYEAES-----PSPPPPPS----------------P 357
             +   ++L    +   +  P  P   + ES     PSPP P                  P
Sbjct: 981  SRPYLVELLSRRAGRPDPEPSEPSKEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKP 1040

Query: 358  PLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEEL 417
               P+P T+ E PS    +G   RK K +L+S+  LDG    +TEKV  ++         
Sbjct: 1041 ASPPLPATQQEKPSQTPEAG---RKEKPMLQSRHSLDGSK--LTEKVETAQPL------- 1088

Query: 418  NMKTSSVHRPPAMTVKKEPREERKGPKKGTAA--LGKANRQVSI 459
               T ++ +      ++  REERK  ++   A  L K N  VS+
Sbjct: 1089 -WITLALQKQKGFREQQATREERKQAREAKQAEKLSKENVSVSV 1131


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 66/286 (23%), Positives = 107/286 (37%), Gaps = 25/286 (8%)

Query: 203 KTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAV--KEE 260
           K +E  +E + E  E   +  A      K        G+    + +   + E+A   +E+
Sbjct: 527 KEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK 586

Query: 261 KIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRK- 319
           K+ E+     T+ +L   A ++K  K   PV     E+K    V  S  E K    + K 
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646

Query: 320 ---KRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKT--------EPE 368
              ++ +  +P+S   E    P S    E ++ S P P SP  E   K         E E
Sbjct: 647 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS-PVPKSPVEEAKSKAEVGKGEQKEEE 705

Query: 369 PPSVKSSSGENK--RKRKRVLKSKTYLDGEGCIVTEKVYESESCTDS-EEELNMKTSSVH 425
              VK +  E K  +K ++          E  +  E V E  + T S +  L  +T    
Sbjct: 706 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 765

Query: 426 RPPAMTVKKEPR-----EERKGPKKGTAALGKANRQVSITGFFQRK 466
           +P     +KE        E +G  KG  A G     +++ G  + K
Sbjct: 766 KPLQQEKEKEKAGGEGGSEEEGSDKG--AKGSRKEDIAVNGEVEGK 809



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 46/204 (22%), Positives = 72/204 (35%), Gaps = 22/204 (10%)

Query: 241 KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR 300
           K    K KV     + + EE  VE     + E   A            E + V  KE+K+
Sbjct: 440 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAI----------TEELAVSMKEEKK 489

Query: 301 GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE 360
                  ++   E E +  K+  +K    +  E+E   +     E E        S   E
Sbjct: 490 EAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE 549

Query: 361 PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTE--KVYESESCTDSEEELN 418
                  E  S K  S E +   +   +++   +GE     E  KV E      ++EEL 
Sbjct: 550 -------EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL- 601

Query: 419 MKTSSVHRP--PAMTVKKEPREER 440
           +  + V +P      V K P EE+
Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEK 625


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 66/286 (23%), Positives = 107/286 (37%), Gaps = 25/286 (8%)

Query: 203 KTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNKFKVNLDSEQAV--KEE 260
           K +E  +E + E  E   +  A      K        G+    + +   + E+A   +E+
Sbjct: 151 KEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK 210

Query: 261 KIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRK- 319
           K+ E+     T+ +L   A ++K  K   PV     E+K    V  S  E K    + K 
Sbjct: 211 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270

Query: 320 ---KRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKT--------EPE 368
              ++ +  +P+S   E    P S    E ++ S P P SP  E   K         E E
Sbjct: 271 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS-PVPKSPVEEAKSKAEVGKGEQKEEE 329

Query: 369 PPSVKSSSGENK--RKRKRVLKSKTYLDGEGCIVTEKVYESESCTDS-EEELNMKTSSVH 425
              VK +  E K  +K ++          E  +  E V E  + T S +  L  +T    
Sbjct: 330 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 389

Query: 426 RPPAMTVKKEPR-----EERKGPKKGTAALGKANRQVSITGFFQRK 466
           +P     +KE        E +G  KG  A G     +++ G  + K
Sbjct: 390 KPLQQEKEKEKAGGEGGSEEEGSDKG--AKGSRKEDIAVNGEVEGK 433



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 46/204 (22%), Positives = 72/204 (35%), Gaps = 22/204 (10%)

Query: 241 KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR 300
           K    K KV     + + EE  VE     + E   A            E + V  KE+K+
Sbjct: 64  KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAI----------TEELAVSMKEEKK 113

Query: 301 GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE 360
                  ++   E E +  K+  +K    +  E+E   +     E E        S   E
Sbjct: 114 EAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE 173

Query: 361 PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTE--KVYESESCTDSEEELN 418
                  E  S K  S E +   +   +++   +GE     E  KV E      ++EEL 
Sbjct: 174 -------EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL- 225

Query: 419 MKTSSVHRP--PAMTVKKEPREER 440
           +  + V +P      V K P EE+
Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEK 249


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 36/154 (23%), Positives = 60/154 (38%), Gaps = 25/154 (16%)

Query: 241 KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR 300
           K  M +  + L+S Q   +    E+    V + ++ +  G     KK E     ++E+K+
Sbjct: 313 KVKMGQLSLGLESGQGQGQH---EESWQDVPQRRVGSGQGGSPCWKKQEQKLDDEEEEKK 369

Query: 301 GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPP------- 353
                  ++E K+ E   K+ R +      ++E E     P      +PSPPP       
Sbjct: 370 -------EEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPST 422

Query: 354 --------PPSPPLEPVPKTEPEPPSVKSSSGEN 379
                   PP PP+ P P   P PP  +    E+
Sbjct: 423 SPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEES 456



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 18/57 (31%), Positives = 27/57 (47%), Gaps = 11/57 (19%)

Query: 351 PPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYES 407
           PPPPP+PP  P P   P P +          +R  +L++  +   E  +   K+YES
Sbjct: 619 PPPPPAPPPPPAPSPPPAPAT--------SSRRPLLLRAPQFTPSEAHL---KIYES 664



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 25/78 (32%), Positives = 31/78 (39%), Gaps = 7/78 (8%)

Query: 319 KKRRRIKLPESDSSEDEVFPD----SPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKS 374
           +  R IK P     ED   P     SP      + SPP P  P   P P   P PPS   
Sbjct: 535 RSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPV 594

Query: 375 SSGENKRKRKRVLKSKTY 392
              E   KR+ +L+  T+
Sbjct: 595 PLPE---KRRSILREPTF 609



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 14/32 (43%), Positives = 16/32 (50%)

Query: 333 EDEVFPDSPGAYEAESPSPPPPPSPPLEPVPK 364
           E  + P   GA EA  P PPP    P EP P+
Sbjct: 663 ESVLTPPPLGAPEAPEPEPPPADDSPAEPEPR 694



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 11/22 (50%), Positives = 13/22 (59%)

Query: 349 PSPPPPPSPPLEPVPKTEPEPP 370
           P+PPPPP+P   P P T    P
Sbjct: 623 PAPPPPPAPSPPPAPATSSRRP 644


>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
            sapiens]
          Length = 3969

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 41/155 (26%), Positives = 63/155 (40%), Gaps = 27/155 (17%)

Query: 241  KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTE---PKLATPAGLKKSSKKAEPVKVLQKE 297
            KA   K K +  SE+   +E  V +  V  ++   P        KKSS +  P K ++++
Sbjct: 1211 KAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPPPRKPVEEK 1270

Query: 298  KKRGKRVALSDDETKE--TENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPP 355
             + G  V+    E+K+  T   RK  +++  P                     P  PP  
Sbjct: 1271 SEEGN-VSAPGPESKQATTPASRKSSKQVSQPA-----------------LVIPPQPPTT 1312

Query: 356  SPPLEPVPKTEPEPPSVKS----SSGENKRKRKRV 386
             PP + VPKT P  P  K      SG  + K+K+V
Sbjct: 1313 GPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKV 1347



 Score = 36.6 bits (83), Expect = 0.050
 Identities = 31/128 (24%), Positives = 55/128 (42%), Gaps = 20/128 (15%)

Query: 285 SKKAEPVKVLQKEKKRGKRV----ALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDS 340
           S+ +E ++VL +E+     V     +S     E+ + R +R  +      S   +     
Sbjct: 490 SQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTL 549

Query: 341 PGAYEAESPSPPPP----PSPPLEP-----------VPKTEP-EPPSVKSSSGENKRKRK 384
             A + ++ S PPP    P PPL+P           +P T P   P + +S+   + KRK
Sbjct: 550 QSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRK 609

Query: 385 RVLKSKTY 392
            +L+  T+
Sbjct: 610 SILREPTF 617



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 54/256 (21%), Positives = 92/256 (35%), Gaps = 50/256 (19%)

Query: 148  SSSSSKKFEQSHLHMSSETQANNELTTNGHGPPASKQVSQQPKGI--------------- 192
            S SS +     HLH+  +    ++ T +     +S     + K +               
Sbjct: 2358 SFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEH 2417

Query: 193  MGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGK-GNMMSNFFGKAAMNKFKVNL 251
            MG  +     K +++ KET  E     +    G    G+ GN+   F             
Sbjct: 2418 MGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFM------------ 2465

Query: 252  DSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKV------LQKEKKRGKRVA 305
              ++ +  E + ++P  +V+  K+           KA P++V      LQ  +KR  +V 
Sbjct: 2466 --DEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVT 2523

Query: 306  LSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPS--PPLEPVP 363
            L+     + EN  + +  +K         E  P SP   E+ SP+ P   S  P   PV 
Sbjct: 2524 LTP---LKMENESQSKNALK---------ESSPASPLQIESTSPTEPISASENPGDGPVA 2571

Query: 364  KTEPEPPSVKSSSGEN 379
            +  P   S + S   N
Sbjct: 2572 QPSPNNTSCQDSQSNN 2587



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 9/84 (10%)

Query: 49   RKENSGAQLHVTYLVSGSL----IQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQ 104
            R E++G + HVT    G      + N HS  +V    +D LEA  S L  +  +H  +  
Sbjct: 2757 RPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPS 2816

Query: 105  KAMLKDSGPLFNTDYDILKSNLQN 128
               L D+   +NT  ++LKS+  N
Sbjct: 2817 DKNLLDT---YNT--ELLKSDSDN 2835



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 18/69 (26%), Positives = 30/69 (43%), Gaps = 11/69 (15%)

Query: 309  DETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPE 368
            +E   TE     ++ I  P+         P  PG  E +SP+P  PP+PP+    ++  +
Sbjct: 1809 EENSHTEQPPLMKKIIPAPK---------PKGPG--EPDSPTPLHPPTPPILSTDRSRED 1857

Query: 369  PPSVKSSSG 377
             P +    G
Sbjct: 1858 SPELNPPPG 1866


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 13/122 (10%)

Query: 252  DSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVL-----QKEKKRGKRVAL 306
            DSE    EE + E P+  V  P  A    L+ SS  A+   +L     Q  K +    +L
Sbjct: 1169 DSETMAPEESLKEAPSAPVILPS-AEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSL 1227

Query: 307  SDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTE 366
             ++ + +    +  RR   +P+ +++E    P+ PG      P PPPPP P +E    + 
Sbjct: 1228 EENNSDKNSGPQGPRRTPTMPQEEAAEKRP-PEPPG------PPPPPPPPPLVEGDLSSA 1280

Query: 367  PE 368
            P+
Sbjct: 1281 PQ 1282



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 38/136 (27%), Positives = 56/136 (41%), Gaps = 23/136 (16%)

Query: 258 KEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKV--LQKEKKRGK---RVALSDDE-- 310
           KE   VE     +   KL     L+KS+   E V V  L  E K      +V L ++   
Sbjct: 430 KENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEK 489

Query: 311 ----------TKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESP----SPPP--P 354
                     T++++ +  K   +   E+++SE E  P  P       P    +PPP  P
Sbjct: 490 HLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTP 549

Query: 355 PSPPLEPVPKTEPEPP 370
           P PPL P+P    +PP
Sbjct: 550 PLPPLPPIPALPQQPP 565


>gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo
           sapiens]
          Length = 634

 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 52/259 (20%), Positives = 94/259 (36%), Gaps = 23/259 (8%)

Query: 221 ASAAGNKAPGKGNMMSNFFGKAAMNKF-KVNLDSEQAVKEEKIVEQPTVSVTEPKLATPA 279
           AS A +  P  G+    F  K  ++   K+    +   K+     + T +V E K++T  
Sbjct: 11  ASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQ 70

Query: 280 --------GLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDS 331
                   G+ K     +    +  E   G  + + ++ T+E   ++ +     + E   
Sbjct: 71  SREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP 130

Query: 332 SEDEVFPDSPGAYEAESPSP-----PP--PPSPPLEPVPKTEPEPPSVKSSSGENKRKRK 384
             +E   D     E  S +P     PP  PP P  +P PK  P PP   ++   +K    
Sbjct: 131 PLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGASHKGDEV 190

Query: 385 RVLKSKTYLDGEGCIV-------TEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPR 437
             +K  T   G+   V            E+   + S++    K S+     + + + +  
Sbjct: 191 PPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSSTSSRPKAS 250

Query: 438 EERKGPKKGTAALGKANRQ 456
           +E    K GT    K  R+
Sbjct: 251 KETVSSKAGTVGTTKGKRK 269


>gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo
           sapiens]
          Length = 645

 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 52/259 (20%), Positives = 94/259 (36%), Gaps = 23/259 (8%)

Query: 221 ASAAGNKAPGKGNMMSNFFGKAAMNKF-KVNLDSEQAVKEEKIVEQPTVSVTEPKLATPA 279
           AS A +  P  G+    F  K  ++   K+    +   K+     + T +V E K++T  
Sbjct: 22  ASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQ 81

Query: 280 --------GLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDS 331
                   G+ K     +    +  E   G  + + ++ T+E   ++ +     + E   
Sbjct: 82  SREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP 141

Query: 332 SEDEVFPDSPGAYEAESPSP-----PP--PPSPPLEPVPKTEPEPPSVKSSSGENKRKRK 384
             +E   D     E  S +P     PP  PP P  +P PK  P PP   ++   +K    
Sbjct: 142 PLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGASHKGDEV 201

Query: 385 RVLKSKTYLDGEGCIV-------TEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPR 437
             +K  T   G+   V            E+   + S++    K S+     + + + +  
Sbjct: 202 PPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSSTSSRPKAS 261

Query: 438 EERKGPKKGTAALGKANRQ 456
           +E    K GT    K  R+
Sbjct: 262 KETVSSKAGTVGTTKGKRK 280


>gi|4557719 DNA ligase I [Homo sapiens]
          Length = 919

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 46/188 (24%), Positives = 80/188 (42%), Gaps = 35/188 (18%)

Query: 267 TVSVTEPKLATPAGLKK--SSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRI 324
           ++S T P  ++P+G+ K  +++K  P + +Q+  +       S+DE +E +  +K+    
Sbjct: 104 SLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQ-----SEDEDREAKR-KKEEEEE 157

Query: 325 KLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRK 384
           + P+   +E EV  +  G  + + P+ PP      +P+  ++ E P+   S  E   K  
Sbjct: 158 ETPKESLTEAEVATEKEGE-DGDQPTTPP------KPLKTSKAETPTESVSEPEVATK-- 208

Query: 385 RVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPREERKG-P 443
                            +++ E E  T          SS   P    VKKE +EE  G P
Sbjct: 209 -----------------QELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAP 251

Query: 444 KKGTAALG 451
            K  AA G
Sbjct: 252 GKEGAAEG 259



 Score = 32.7 bits (73), Expect = 0.72
 Identities = 25/109 (22%), Positives = 45/109 (41%), Gaps = 13/109 (11%)

Query: 258 KEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENM 317
           KEE+  E P  S+TE ++AT    +   +   P K L+  K      ++S+ E    + +
Sbjct: 152 KEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQEL 211

Query: 318 RKKRRRIK-------------LPESDSSEDEVFPDSPGAYEAESPSPPP 353
           +++  + K              P   + + EV  + PGA   E  +  P
Sbjct: 212 QEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGP 260


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
           [Homo sapiens]
          Length = 1490

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 38/136 (27%), Positives = 56/136 (41%), Gaps = 23/136 (16%)

Query: 258 KEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKV--LQKEKKRGK---RVALSDDE-- 310
           KE   VE     +   KL     L+KS+   E V V  L  E K      +V L ++   
Sbjct: 430 KENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEK 489

Query: 311 ----------TKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESP----SPPP--P 354
                     T++++ +  K   +   E+++SE E  P  P       P    +PPP  P
Sbjct: 490 HLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTP 549

Query: 355 PSPPLEPVPKTEPEPP 370
           P PPL P+P    +PP
Sbjct: 550 PLPPLPPIPALPQQPP 565



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 31/112 (27%), Positives = 48/112 (42%), Gaps = 6/112 (5%)

Query: 252  DSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVL-----QKEKKRGKRVAL 306
            DSE    EE + E P+  V  P  A    L+ SS  A+   +L     Q  K +    +L
Sbjct: 1169 DSETMAPEESLKEAPSAPVILPS-AEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSL 1227

Query: 307  SDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPP 358
             ++ + +    +  RR   +P+ +++        P     E P PPPPP PP
Sbjct: 1228 EENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPP 1279


>gi|158534059 formin binding protein 4 [Homo sapiens]
          Length = 1017

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 4/76 (5%)

Query: 341 PGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIV 400
           P A   E P PPPPP PP  P PK    PP  K+  G   + +K   K  + +     I 
Sbjct: 898 PTATIIEPPPPPPPPPPPPPPAPKM---PPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQ 954

Query: 401 TEKVYESESCTDSEEE 416
            E + E ++ + SEE+
Sbjct: 955 RE-LDEEDNSSSSEED 969



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 12/21 (57%), Positives = 13/21 (61%)

Query: 351 PPPPPSPPLEPVPKTEPEPPS 371
           PPPPP PP  P P   P PP+
Sbjct: 712 PPPPPPPPESPPPPPPPPPPA 732



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 27/98 (27%), Positives = 33/98 (33%), Gaps = 35/98 (35%)

Query: 347 ESPSPPPPPSPPLE-----------------PVPKTEPEPP------------------S 371
           ESP PPPPP PP E                 P P TE + P                  +
Sbjct: 720 ESPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDST 779

Query: 372 VKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESES 409
           + SSS     KRK    S   +     I +  V  S+S
Sbjct: 780 ISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQS 817



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 14/40 (35%), Positives = 18/40 (45%)

Query: 341 PGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENK 380
           P   E   P PPPP SPP  P P    E   ++    E++
Sbjct: 706 PLPLEMPPPPPPPPESPPPPPPPPPPAEDGEIQEVEMEDE 745


>gi|58761544 amine oxidase (flavin containing) domain 2 isoform a
           [Homo sapiens]
          Length = 876

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/160 (27%), Positives = 61/160 (38%), Gaps = 12/160 (7%)

Query: 221 ASAAGNKA-PGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPA 279
           A+A G +A PG      N    AA       L     V    + E+       P+ + P 
Sbjct: 16  AAATGTEAGPGTAGGSENGSEVAAQ---PAGLSGPAEVGPGAVGERTPRKKEPPRASPPG 72

Query: 280 GLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKE-TENMRKKRRRIKLPESDSS-----E 333
           GL +    A P             +     ET E     R+KR +++  E D S     E
Sbjct: 73  GLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSE 132

Query: 334 DEVFPDSPGAYEAESPS--PPPPPSPPLEPVPKTEPEPPS 371
           DE + +     +AE     PPPPP  P E   ++EPE PS
Sbjct: 133 DEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPS 172


>gi|58761546 amine oxidase (flavin containing) domain 2 isoform b
           [Homo sapiens]
          Length = 852

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/160 (27%), Positives = 61/160 (38%), Gaps = 12/160 (7%)

Query: 221 ASAAGNKA-PGKGNMMSNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPA 279
           A+A G +A PG      N    AA       L     V    + E+       P+ + P 
Sbjct: 16  AAATGTEAGPGTAGGSENGSEVAAQ---PAGLSGPAEVGPGAVGERTPRKKEPPRASPPG 72

Query: 280 GLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKE-TENMRKKRRRIKLPESDSS-----E 333
           GL +    A P             +     ET E     R+KR +++  E D S     E
Sbjct: 73  GLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSE 132

Query: 334 DEVFPDSPGAYEAESPS--PPPPPSPPLEPVPKTEPEPPS 371
           DE + +     +AE     PPPPP  P E   ++EPE PS
Sbjct: 133 DEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPS 172


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 18/33 (54%), Positives = 21/33 (63%), Gaps = 1/33 (3%)

Query: 339 DSPGAYEAESPSPPPPPSPP-LEPVPKTEPEPP 370
           +SPGA  A  P PPPPP+PP  +P P   P PP
Sbjct: 12  ESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPP 44



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 20/55 (36%), Positives = 23/55 (41%), Gaps = 7/55 (12%)

Query: 338 PDSPGAYEAESPSPPPPPSPPLEP-------VPKTEPEPPSVKSSSGENKRKRKR 385
           P  P A   + P PPPPP+PP  P        P+ E  PP      G   R R R
Sbjct: 24  PPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGGPRGRLRSR 78



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 14/30 (46%), Positives = 18/30 (60%), Gaps = 1/30 (3%)

Query: 341 PGAYEAESPSPPPPPSPPLEPVPKTEPEPP 370
           PG     +P+P PPP PP  P P+ +P PP
Sbjct: 10  PGESPGATPAPGPPPPPPPAP-PQQQPPPP 38



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 17/32 (53%), Positives = 18/32 (56%), Gaps = 5/32 (15%)

Query: 341 PG-AYEAESPSPPPPPSPPLEP----VPKTEP 367
           PG A  A SP PPPP SPP  P     P+T P
Sbjct: 763 PGPAPAAASPGPPPPASPPGAPASPRAPRTSP 794


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
           sapiens]
          Length = 2524

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/367 (20%), Positives = 133/367 (36%), Gaps = 59/367 (16%)

Query: 116 NTDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTN 175
           N   D+LK    + S     +  A   +    ++S  ++  +    M++E  +   +T  
Sbjct: 540 NDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQ 599

Query: 176 GHGPPASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASA--AGNKAPGK-G 232
                AS ++++         +S+   +  ET K+   E     +A A   G+K   +  
Sbjct: 600 QSAELASMELNE---------SSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCK 650

Query: 233 NMMSNFFGKAAMNKF----KVNLDSEQAVKEEKIVEQPTVS-------VTEPKLATPAGL 281
           N   N+  +  +++     K+ ++ E+  + +K       S       V E +    +G+
Sbjct: 651 NFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGV 710

Query: 282 KKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSED--EVFPD 339
             S  + E V+  +     G  V   +     T N       I  P +++++D  +  P 
Sbjct: 711 --SGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPK 768

Query: 340 SPGAYEAESPSPPPPPSP------PLEPVPKTE----PEPPSVKSSSG------ENKRKR 383
            P    A+ P P PP  P      P EP P +E    P PP    S          + K 
Sbjct: 769 PPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKE 828

Query: 384 KRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKEPREE-RKG 442
           +    +    +GE           E    + EEL + T     P    VK E  EE  +G
Sbjct: 829 EETAAAPPVEEGE-----------EQKPPAAEELAVDTGKAEEP----VKSECTEEAEEG 873

Query: 443 PKKGTAA 449
           P KG  A
Sbjct: 874 PAKGKDA 880



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 45/207 (21%), Positives = 74/207 (35%), Gaps = 31/207 (14%)

Query: 179  PPASKQVSQQPKGIMGMFASKAAAKTQETNKETK-TEAKEVTNASA--AGNKAPGKGNMM 235
            PPA+++++           S+   + +E   + K  EA E T   A  A  K  G G   
Sbjct: 845  PPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRAT 904

Query: 236  SNFFGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQ 295
            +     A  +       S   V E +  ++  +    P L TP G  +++  A P K L 
Sbjct: 905  TAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRAN--ASPQKPLD 962

Query: 296  KEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPP 355
             ++ + +  A+    TK  E  R                          E  +P+ P PP
Sbjct: 963  LKQLKQRAAAIPPIVTKVHEPPR--------------------------EDAAPTKPAPP 996

Query: 356  SPPLEPVPKTEPEPPSVKSSSGENKRK 382
            +PP     + E + P    SS   K +
Sbjct: 997  APPPPQNLQPESDAPQQPGSSPRGKSR 1023



 Score = 29.3 bits (64), Expect = 8.0
 Identities = 26/95 (27%), Positives = 36/95 (37%), Gaps = 4/95 (4%)

Query: 347 ESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYE 406
           E  + PP P  P+ P P        V+    EN   RK+   +   L+G G  V   +Y 
Sbjct: 202 EEAAKPPEPEKPVSPPPIESKHRSLVQIIYDEN---RKKAEAAHRILEGLGPQVELPLYN 258

Query: 407 SESCTDSEEELNMKTSSVHRPPAMTVKKEPREERK 441
             S T    E N+K +   R   +   K     RK
Sbjct: 259 QPSDTRQYHE-NIKINQAMRKKLILYFKRRNHARK 292


>gi|38788260 bromodomain PHD finger transcription factor isoform 2
            [Homo sapiens]
          Length = 2903

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/157 (26%), Positives = 70/157 (44%), Gaps = 17/157 (10%)

Query: 248  KVNLDSEQAVKE---EKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRV 304
            K++ + +QA K+   E+ VEQ        KL+      K   +AE   +L+K     K +
Sbjct: 2564 KIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAE---ILKKRALLDKDL 2620

Query: 305  ALS-DDETKETENMRKKRRRIKLPESDSSEDEVFPDSPG--AYEAESPSPPPPP------ 355
             +   +E K    ++K++  ++L ++ +      P +P   A  A  PSPPPPP      
Sbjct: 2621 QIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTG 2680

Query: 356  --SPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSK 390
              S P  P    + +    K SS ++K+K+     SK
Sbjct: 2681 LLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSK 2717



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 13/23 (56%), Positives = 15/23 (65%), Gaps = 2/23 (8%)

Query: 338 PDSPGAYEAE--SPSPPPPPSPP 358
           P  P A  AE  +P+PPPPP PP
Sbjct: 9   PKQPAAPAAERCAPAPPPPPPPP 31



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 13/53 (24%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query: 320  KRRRIKL-PESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPS 371
            ++R+ KL P+    +D+  P +  +    + + P    P  +P P+T+P+ P+
Sbjct: 2363 EQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPA 2415


>gi|38788274 bromodomain PHD finger transcription factor isoform 1
            [Homo sapiens]
          Length = 2920

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/157 (26%), Positives = 70/157 (44%), Gaps = 17/157 (10%)

Query: 248  KVNLDSEQAVKE---EKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRV 304
            K++ + +QA K+   E+ VEQ        KL+      K   +AE   +L+K     K +
Sbjct: 2581 KIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAE---ILKKRALLDKDL 2637

Query: 305  ALS-DDETKETENMRKKRRRIKLPESDSSEDEVFPDSPG--AYEAESPSPPPPP------ 355
             +   +E K    ++K++  ++L ++ +      P +P   A  A  PSPPPPP      
Sbjct: 2638 QIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTG 2697

Query: 356  --SPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSK 390
              S P  P    + +    K SS ++K+K+     SK
Sbjct: 2698 LLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSK 2734



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 13/23 (56%), Positives = 15/23 (65%), Gaps = 2/23 (8%)

Query: 338 PDSPGAYEAE--SPSPPPPPSPP 358
           P  P A  AE  +P+PPPPP PP
Sbjct: 9   PKQPAAPAAERCAPAPPPPPPPP 31



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 13/53 (24%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query: 320  KRRRIKL-PESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPS 371
            ++R+ KL P+    +D+  P +  +    + + P    P  +P P+T+P+ P+
Sbjct: 2237 EQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPA 2289


>gi|158420731 chromodomain helicase DNA binding protein 3 isoform 3
           [Homo sapiens]
          Length = 2059

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 29/114 (25%), Positives = 49/114 (42%), Gaps = 22/114 (19%)

Query: 288 AEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFP--------- 338
           A P++   +E++  + V   ++E +E E   ++   ++  + D  ED+            
Sbjct: 2   ASPLR--DEEEEEEEMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHD 59

Query: 339 ------DSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVK---SSSGENKRKR 383
                   PG +    P PPPPP PP  P P   P+   ++   S+ G  KRKR
Sbjct: 60  RGRDRHSPPGCHLFPPPPPPPPPLPP--PPPPPPPDKDDIRLLPSALGVKKRKR 111



 Score = 32.3 bits (72), Expect = 0.94
 Identities = 33/135 (24%), Positives = 55/135 (40%), Gaps = 27/135 (20%)

Query: 331 SSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSK 390
           SS   + P  P       P+ PPPP+  ++P P    +    K    + + K  RV   +
Sbjct: 288 SSATPIAPSGP-------PALPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKSPRVPDGR 340

Query: 391 TYLDGE---------GCIVTEK------VYESESCTDSE-EELNMKTSSVH----RPPAM 430
             L G+         G +  ++      V++S+   + E EE ++ + SVH    RP   
Sbjct: 341 KKLRGKKMAPLKIKLGLLGGKRKKGGSYVFQSDEGPEPEAEESDLDSGSVHSASGRPDGP 400

Query: 431 TVKKEPREERKGPKK 445
              K+ +  R G KK
Sbjct: 401 VRTKKLKRGRPGRKK 415



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 35/107 (32%), Positives = 44/107 (41%), Gaps = 18/107 (16%)

Query: 269  SVTEPKLATP-AGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLP 327
            S T+    TP A    S   ++P      EK  G R  L   E +E EN  +K      P
Sbjct: 1592 SPTKTSPTTPEASATNSPCTSKPATPAPSEKGEGIRTPL---EKEEAENQEEK------P 1642

Query: 328  ESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEP--VPKTEPEPPSV 372
            E +S   E         EA++PSP P     LEP  +P  E E P V
Sbjct: 1643 EKNSRIGEKMET-----EADAPSPAPSLGERLEPRKIP-LEDEVPGV 1683


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 48/208 (23%), Positives = 84/208 (40%), Gaps = 29/208 (13%)

Query: 246  KFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVA 305
            K  V +  ++     K+ E P   V E K+  P   KK +  A+ V  +QK     +++ 
Sbjct: 9328 KKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAK-VPEVQKGVVTEEKIT 9386

Query: 306  LSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKT 365
            +     +       +  + K+PE    E +  P      E E P PP  P+ P +PVP+ 
Sbjct: 9387 IVTQREESPPPAVPEIPKKKVPE----ERKPVPRK----EEEVPPPPKVPALPKKPVPEE 9438

Query: 366  E---PEPPSVKSSSGENKRKRKRVLKSKTYLDGEGC---------IVTEKVYESESCTDS 413
            +   P P + K+     +  +K V++ K ++  E           +   +V   E  + S
Sbjct: 9439 KVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYS 9498

Query: 414  EEELNMKTSSVHRPPAMTVKKEPREERK 441
            EEE  +  S          ++E REE +
Sbjct: 9499 EEEEGVSIS--------VYREEEREEEE 9518



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 60/245 (24%), Positives = 95/245 (38%), Gaps = 33/245 (13%)

Query: 179   PPASKQVSQQPKGIMG-----MFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGN 233
             PPA   V ++PK I+      +     A   +E   E   E  ++         AP K +
Sbjct: 10836 PPA---VPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKED 10892

Query: 234   MMSNFFGKAAMNKFKVNLDSEQAVK-----------EEKIVEQPTVSVTEPK--LATPAG 280
             +    F   A+ K KV    +   K           E+K+ +       EPK  +   + 
Sbjct: 10893 VKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSV 10952

Query: 281   LKKSSKKAEPVKVLQKEKKRGKRVALSDD------ETKETENMRKKRRRI----KLPESD 330
             L+K  ++ EP KV  K+ ++ K+ A+ +       E  E   + K+ R+I    K+PE  
Sbjct: 10953 LRKRPEEEEP-KVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIK 11011

Query: 331   SSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSSGENKRKRKRVLKSK 390
              +     P+     EAE  +  PPP  P EP P   P    V     E K  ++   K K
Sbjct: 11012 PAIPLPAPEPKPKPEAEVKTIKPPPVEP-EPTPIAAPVTVPVVGKKAEAKAPKEEAAKPK 11070

Query: 391   TYLDG 395
               + G
Sbjct: 11071 GPIKG 11075



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 32/129 (24%), Positives = 54/129 (41%), Gaps = 25/129 (19%)

Query: 258   KEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENM 317
             +EE + E+  +   +PK+  PA + +  KK    KV+  +K+      + +   K  E  
Sbjct: 10164 EEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEE-- 10221

Query: 318   RKKRRRIKLPESDS---------------SEDEVFPDSPGAYEAESPSPPPPPSPPLEPV 362
                 +RI LP+ +                SE+E+  + P   E E  +PP  P    E +
Sbjct: 10222 ----KRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVP----EVI 10273

Query: 363   PKTEPEPPS 371
              K  PE P+
Sbjct: 10274 KKAVPEAPT 10282



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 47/192 (24%), Positives = 75/192 (39%), Gaps = 22/192 (11%)

Query: 257   VKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETEN 316
             +K +++V +  V V   ++A P  + +  K+ EP           + VA  ++     E 
Sbjct: 9872  MKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEP-----------EEVAFEEEVVTHVEE 9920

Query: 317   --MRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKS 374
               + ++   I   E   +E+EV P  P     E P  P P      PVPK +  PP+   
Sbjct: 9921  YLVEEEEEYIHEEEEFITEEEVVPVIP-VKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVP 9979

Query: 375   SSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKT-SSVHRPPAMT-- 431
                +   ++  VL  K            KV E       EE++ +     V  PPA    
Sbjct: 9980  EVPKKPEEKVPVLIPKKEKPPPA-----KVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPE 10034

Query: 432   VKKEPREERKGP 443
             V K+P  E+K P
Sbjct: 10035 VPKKPVPEKKVP 10046



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 63/315 (20%), Positives = 109/315 (34%), Gaps = 56/315 (17%)

Query: 179   PPASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNF 238
             PP      ++   ++         K  E  KE   E K            P K   +   
Sbjct: 10696 PPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVP-- 10753

Query: 239   FGKAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEK 298
               K  + + KV +  +  V   K+ E P   V E K A P   +  S    P +V ++ +
Sbjct: 10754 --KEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESP---PPEVYEEPE 10808

Query: 299   KRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDS--PGAYEAESPSP----- 351
             +      ++ +E K      ++   +  P       ++ P+   P   + E+P P     
Sbjct: 10809 EIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEP 10868

Query: 352   --------------PPPPSPP----------LEPVPKTE-PEPPSVKSS--------SGE 378
                           PPPP+PP          L+ +PK + PE P V            G 
Sbjct: 10869 EKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGG 10928

Query: 379   NKRKRKRVLKSKTYLDGE---GCIVTEKVYESESCTDSEEELNMKTSSVHRPP------A 429
              K+ RK + + K     E     ++ ++  E E   + ++   +K  +V  PP       
Sbjct: 10929 EKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEE 10988

Query: 430   MTVKKEPREERKGPK 444
             + V    + ERK P+
Sbjct: 10989 VEVPTVTKRERKIPE 11003



 Score = 36.2 bits (82), Expect = 0.065
 Identities = 41/189 (21%), Positives = 73/189 (38%), Gaps = 39/189 (20%)

Query: 252  DSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDET 311
            + E  V E +++E+P   V E KL     +     +AEP +V ++++K+   + L     
Sbjct: 9517 EEEAEVTEYEVMEEPEEYVVEEKLH----IISKRVEAEPAEVTERQEKK---IVLKPKIP 9569

Query: 312  KETENMRKKRRRIKLPESDSSEDEVFPDS--PGAYEAESPSPPPP-PSPPLEPVPKTEPE 368
             + E         K+PE+     ++ P+   P     +   PPP  P  P +PVP+ +  
Sbjct: 9570 AKIEEPPPA----KVPEAPK---KIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVP 9622

Query: 369  PPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPP 428
            P  +K                          +  KV E       EE++ +  +    PP
Sbjct: 9623 PKVIKMEEP----------------------LPAKVTERHMQITQEEKVLVAVTKKEAPP 9660

Query: 429  AMTVKKEPR 437
               V +EP+
Sbjct: 9661 KARVPEEPK 9669



 Score = 35.8 bits (81), Expect = 0.085
 Identities = 36/127 (28%), Positives = 47/127 (37%), Gaps = 28/127 (22%)

Query: 261   KIVEQPTVSVTEPKLATPAGLKKS---SKKAEPVKVLQKEKKRGKRVALSDDETKETENM 317
             K+ E P   V E K+  P   K     +K  E  KV   EKK  + +    +        
Sbjct: 10608 KVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPP----- 10662

Query: 318   RKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPS---PPLEPVPK--------TE 366
                      PE     +EV  + P A   E P P  PP    PP +PVP+         +
Sbjct: 10663 ---------PEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKK 10713

Query: 367   PEPPSVK 373
             PE P VK
Sbjct: 10714 PELPPVK 10720



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 37/135 (27%), Positives = 52/135 (38%), Gaps = 21/135 (15%)

Query: 325  KLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE------PVPKTEP-EPPSVKSSSG 377
            +LPE  + E+      P   E  +P  P  P  P+       PVPK EP  PP V     
Sbjct: 9290 ELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPK 9349

Query: 378  ENKRKRK---RVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRP----PAM 430
            +   + K    V K K            KV E +    +EE++ + T     P    P +
Sbjct: 9350 KPVPEEKIPVPVAKKKE-------APPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEI 9402

Query: 431  TVKKEPREERKGPKK 445
              KK P E +  P+K
Sbjct: 9403 PKKKVPEERKPVPRK 9417



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 45/198 (22%), Positives = 76/198 (38%), Gaps = 16/198 (8%)

Query: 264   EQPTVSVTEPKLATPAGLKKSSKKAE---PVKVLQKEKKRGKRVA------LSDDETKET 314
             E+  V V + K A PA + +  KK E   PV + +KEK    +V       + +++    
Sbjct: 9961  EKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVP 10020

Query: 315   ENMRKKRRRIKLPESDSS---EDEVFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPPS 371
                + +    K+PE       E +V   +P   EA     P  P   +    K  P P  
Sbjct: 10021 VPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKK 10080

Query: 372   VKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMT 431
             V++   +  +KR+ V         E  +  E++   E     EEE+  +   V       
Sbjct: 10081 VEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEV 10140

Query: 432   VKKE----PREERKGPKK 445
             + +E    P EE   P++
Sbjct: 10141 LPEEEEIPPEEEEVPPEE 10158



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 55/248 (22%), Positives = 98/248 (39%), Gaps = 55/248 (22%)

Query: 241  KAAMNKFKVNLDSEQAVKEEKIV-------EQPTVSVTEPKLAT----PAGLKKSSKKAE 289
            K A  K +V  + ++AV EEK++       E+P   VTE +          ++   ++ +
Sbjct: 9656 KEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQ 9715

Query: 290  PVK--VLQKEKKRG-----KRVALSDDET---------KETENMRKKRRRIKLPESDSSE 333
            P+K   + +EK+R      + V++  +E          KE E         +  E +  E
Sbjct: 9716 PIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEERE 9775

Query: 334  DEVF---------PDSPGAYEA--ESPSPPPPPSPPLEPVPKTEPE-------PPSVKSS 375
             E +         P+ P   +   E P P  P +PP + + K  PE       P  +K  
Sbjct: 9776 YERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPP 9835

Query: 376  SGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSSVHRPPAMTVKKE 435
              +   + K+V + K  +      +T++  E E  T+   ++ MK   V     + V   
Sbjct: 9836 PPKVPEEPKKVFEEKIRIS-----ITKR--EKEQVTEPAAKVPMKPKRVVAEEKVPV--- 9885

Query: 436  PREERKGP 443
            PR+E   P
Sbjct: 9886 PRKEVAPP 9893



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 36/134 (26%), Positives = 53/134 (39%), Gaps = 13/134 (9%)

Query: 261  KIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKK 320
            K+ E P   V E K+  P   K+   K  P KV ++ KK      +     K  E +  K
Sbjct: 9579 KVPEAPKKIVPEKKVPAPVPKKE---KVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAK 9635

Query: 321  --RRRIKLPESDSSEDEVFPDS--PGAYEAESPSPPPPPSPPLEPVPKTEPEPPSVKSSS 376
               R +++ + +     V      P A   E P    P    L+  PK E EPP+  +  
Sbjct: 9636 VTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEF 9695

Query: 377  GENKRKRKRVLKSK 390
                  RKRV+K +
Sbjct: 9696 ------RKRVVKEE 9703



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 32/127 (25%), Positives = 55/127 (43%), Gaps = 16/127 (12%)

Query: 261   KIVEQPTVSVTEPKLATPAGLKKSSK----KAEPVKVLQKEKKRGK-----RVALSDDET 311
             ++ E   V V E   A P G + S K    K  P KV+ +++   K     +  + +++ 
Sbjct: 10423 EVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKV 10482

Query: 312   KETENMRKKRRRIK--LPESDSSEDEVFPDSPGAYEAESPSPPPPPSP----PLEPVPKT 365
             +  E  R    ++   LP  +   ++  P  P A + E+P P  P +P    P + VP  
Sbjct: 10483 RVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPP-AKKPEAPPPKVPEAPKEVVPEKKVPVP 10541

Query: 366   EPEPPSV 372
              P+ P V
Sbjct: 10542 PPKKPEV 10548



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 36/145 (24%), Positives = 58/145 (40%), Gaps = 12/145 (8%)

Query: 304   VALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLEPVP 363
             + L     +E   + K  R I++ E++  E    P +P      S    PP  PP + VP
Sbjct: 10402 IKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVP 10461

Query: 364   KTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMKTSS 423
             + EP P  V       +  +K V++ K  +  E  +   KV E     +   E  +    
Sbjct: 10462 RKEP-PAKVP------EVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPP 10514

Query: 424   VHRP--PAMTVKKEPRE---ERKGP 443
               +P  P   V + P+E   E+K P
Sbjct: 10515 AKKPEAPPPKVPEAPKEVVPEKKVP 10539



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 48/192 (25%), Positives = 68/192 (35%), Gaps = 24/192 (12%)

Query: 187   QQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFGKAAMNK 246
             Q PK   G        + Q+T K+T       + +S    K P         F   A NK
Sbjct: 17626 QPPKDDGGSPVINYIVEKQDTRKDTWGVVS--SGSSKTKLKIPHLQKGCEYVFRVRAENK 17683

Query: 247   FKVN--LDSEQAVKEEKIVE-----QPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKK 299
               V   LDS   V + K        +P V+      AT +     S    P+     E++
Sbjct: 17684 IGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERR 17743

Query: 300   R--GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPP---- 353
                GK V ++     +T     K R   L E ++ E  VF ++       SPS  P    
Sbjct: 17744 EVTGKWVRVN-----KTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKAC 17798

Query: 354   ----PPSPPLEP 361
                 PP PP+ P
Sbjct: 17799 RPIKPPGPPINP 17810



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 52/272 (19%), Positives = 110/272 (40%), Gaps = 31/272 (11%)

Query: 117   TDYDILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNG 176
             +DY  L     + + +++ +    VPR+     + ++ +  S    +SE +A++ +    
Sbjct: 32456 SDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVRE-- 32513

Query: 177   HGPPASKQVSQQPKGIMGMFASKAA----AKTQETNKETKTEAKEVTNASAAGNKAPGKG 232
                    Q+++  + +     S +A    A  +E + E K+  +++    AA  +   K 
Sbjct: 32514 ----VKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAA--RILTKP 32567

Query: 233   NMMSNFFGKAAMNKFKVNLDSEQAV------KEEKIVEQPTVSVTEPKLATP---AGLKK 283
               M+ + G++A  +F  + D E         K + +       VT  K  +    + ++ 
Sbjct: 32568 RSMTVYEGESA--RFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQA 32625

Query: 284   SSKKAEPVKVLQKEKKRGKRVALSDDETKETEN-------MRKKRRRIKLPESDSSEDEV 336
             S +    V V   E K+     L+  + + TE        ++    R+K PE+  S   V
Sbjct: 32626 SDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRV 32685

Query: 337   FPDSPGAYEAESPS-PPPPPSPPLEPVPKTEP 367
                 P   +A SP+   P P+  ++ +P + P
Sbjct: 32686 KSPEPSHPKAVSPTETKPTPTEKVQHLPVSAP 32717


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.123    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,407,981
Number of Sequences: 37866
Number of extensions: 1023677
Number of successful extensions: 22477
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 442
Number of HSP's successfully gapped in prelim test: 759
Number of HSP's that attempted gapping in prelim test: 12821
Number of HSP's gapped (non-prelim): 6824
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.