BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|124107616 claudin 23 [Homo sapiens] (292 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|124107616 claudin 23 [Homo sapiens] 610 e-175 gi|11141861 claudin 9 [Homo sapiens] 86 3e-17 gi|4502877 claudin 4 [Homo sapiens] 76 3e-14 gi|153792768 claudin 6 [Homo sapiens] 73 3e-13 gi|153792186 claudin 7 [Homo sapiens] 68 8e-12 gi|225703142 claudin 14 [Homo sapiens] 67 1e-11 gi|21536294 claudin 14 [Homo sapiens] 67 1e-11 gi|225703138 claudin 14 [Homo sapiens] 67 1e-11 gi|6912314 claudin 14 [Homo sapiens] 67 1e-11 gi|225703140 claudin 14 [Homo sapiens] 67 1e-11 gi|10863887 claudin 1 [Homo sapiens] 67 2e-11 gi|4502875 claudin 3 [Homo sapiens] 66 3e-11 gi|6912316 claudin 17 [Homo sapiens] 66 3e-11 gi|7656981 claudin 15 [Homo sapiens] 66 3e-11 gi|9966781 claudin 2 [Homo sapiens] 64 1e-10 gi|183979973 claudin 19 isoform a [Homo sapiens] 61 1e-09 gi|183979975 claudin 19 isoform b [Homo sapiens] 60 2e-09 gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] 59 4e-09 gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] 59 5e-09 gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] 59 5e-09 gi|40788011 claudin 8 [Homo sapiens] 57 2e-08 gi|50345279 claudin 18 isoform 2 [Homo sapiens] 56 4e-08 gi|157820127 claudin-like [Homo sapiens] 54 1e-07 gi|162417973 claudin 22 [Homo sapiens] 54 2e-07 gi|195947374 claudin 5 [Homo sapiens] 52 5e-07 gi|195947372 claudin 5 [Homo sapiens] 52 5e-07 gi|7705961 claudin 18 isoform 1 [Homo sapiens] 52 5e-07 gi|47716519 claudin 20 [Homo sapiens] 49 4e-06 gi|33598916 claudin 10 isoform a [Homo sapiens] 44 2e-04 gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] 43 4e-04 >gi|124107616 claudin 23 [Homo sapiens] Length = 292 Score = 610 bits (1574), Expect = e-175 Identities = 292/292 (100%), Positives = 292/292 (100%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRE 60 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRE Sbjct: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRE 60 Query: 61 RECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVV 120 RECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVV Sbjct: 61 RECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVV 120 Query: 121 LFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALS 180 LFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALS Sbjct: 121 LFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALS 180 Query: 181 FAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLAPAIKYYSDGQHRPPPAQHRKPK 240 FAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLAPAIKYYSDGQHRPPPAQHRKPK Sbjct: 181 FAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLAPAIKYYSDGQHRPPPAQHRKPK 240 Query: 241 PKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPSCSTHPCDSSLPCDSDL 292 PKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPSCSTHPCDSSLPCDSDL Sbjct: 241 PKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPSCSTHPCDSSLPCDSDL 292 >gi|11141861 claudin 9 [Homo sapiens] Length = 217 Score = 86.3 bits (212), Expect = 3e-17 Identities = 74/206 (35%), Positives = 101/206 (49%), Gaps = 13/206 (6%) Query: 9 LGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE--LYQGLWDMCREQSSRERECGQT 66 LGM LA G L L P W+ V F+ + V +++GLW C QS+ + +C Sbjct: 9 LGMTLAVLGWLGTLVSCALPLWK-VTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVY 67 Query: 67 DQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW---QDE---PNFVLAGLSGVV 120 D Q + ARAL V +L +LGLL+A G +C +DE VL +GV+ Sbjct: 68 DSLLALP-QDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLT--AGVI 124 Query: 121 LFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALS 180 L +AG+L LIPV W H + P A + ++ SL LG+ + LL+LGG L + Sbjct: 125 LLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCT 184 Query: 181 FAPWCDERCRRRRKGPSAGPRRSSVS 206 P ER R R G S P RS S Sbjct: 185 CPPPQVERPRGPRLGYSI-PSRSGAS 209 >gi|4502877 claudin 4 [Homo sapiens] Length = 209 Score = 76.3 bits (186), Expect = 3e-14 Identities = 59/188 (31%), Positives = 92/188 (48%), Gaps = 8/188 (4%) Query: 6 VMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE--LYQGLWDMCREQSSREREC 63 + +G+ LA G L + P WR V F+ + +++GLW C QS+ + +C Sbjct: 6 LQVMGIALAVLGWLAVMLCCALPMWR-VTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQC 64 Query: 64 GQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLG---VRCWQDEPNFVLAGL-SGV 119 D Q + ARAL++ S+ LG+LL+ +G C +DE + +GV Sbjct: 65 KVYDSLLALP-QDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGV 123 Query: 120 VLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLAL 179 V +AGL+ ++PVSW H + P AS ++ SL +G+ S LLLLGG L Sbjct: 124 VFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCC 183 Query: 180 SFAPWCDE 187 + P D+ Sbjct: 184 NCPPRTDK 191 >gi|153792768 claudin 6 [Homo sapiens] Length = 220 Score = 73.2 bits (178), Expect = 3e-13 Identities = 57/180 (31%), Positives = 85/180 (47%), Gaps = 8/180 (4%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE--LYQGLWDMCREQSS 58 M + + LG+VL G + L P W+ V F+ + V +++GLW C QS+ Sbjct: 1 MASAGMQILGVVLTLLGWVNGLVSCALPMWK-VTAFIGNSIVVAQVVWEGLWMSCVVQST 59 Query: 59 RERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW----QDEPNFVLA 114 + +C D Q + ARAL V +L + GLL+ G +C + + L Sbjct: 60 GQMQCKVYDSLLALP-QDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLV 118 Query: 115 GLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 SG+V ++G+L LIPV W H + P A ++ SL LG+ S LLLLGG Sbjct: 119 LTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGG 178 >gi|153792186 claudin 7 [Homo sapiens] Length = 211 Score = 68.2 bits (165), Expect = 8e-12 Identities = 49/180 (27%), Positives = 84/180 (46%), Gaps = 11/180 (6%) Query: 9 LGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE-LYQGLWDMCREQSSRERECGQTD 67 LG +A G + + T P W++ + + + +Y+GLW C QS+ C D Sbjct: 9 LGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYD 68 Query: 68 QWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ-------DEPNFVLAGLSGVV 120 A + RALMV SL L + +A++G++C + + + G G++ Sbjct: 69 SVLALSAA-LQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGG--GII 125 Query: 121 LFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALS 180 VAGL L+ SWY H + P + + + ++ +G+ GS L++LGG L+ S Sbjct: 126 FIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGALLSCS 185 >gi|225703142 claudin 14 [Homo sapiens] Length = 239 Score = 67.4 bits (163), Expect = 1e-11 Identities = 60/212 (28%), Positives = 94/212 (44%), Gaps = 13/212 (6%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGF-LNQPVDVELYQGLWDMCREQSSR 59 M + V LG +L+ G++ L T+ P WR N V +GLW C S+ Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60 Query: 60 ERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ----DEPNFVLAG 115 +C Q + Q + ARALMV S + + A +G++C + A Sbjct: 61 IYQC-QIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAI 119 Query: 116 LSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGF 175 L G + +AGLL ++ VSW + + P S + ++ +L LG++ S L L+GG Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179 Query: 176 SLALSFAPWCDERCRRRRKGPSAGPRRSSVST 207 L LS C + R P P R++ +T Sbjct: 180 LLCLS----CQDEAPYR---PYQAPPRATTTT 204 >gi|21536294 claudin 14 [Homo sapiens] Length = 239 Score = 67.4 bits (163), Expect = 1e-11 Identities = 60/212 (28%), Positives = 94/212 (44%), Gaps = 13/212 (6%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGF-LNQPVDVELYQGLWDMCREQSSR 59 M + V LG +L+ G++ L T+ P WR N V +GLW C S+ Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60 Query: 60 ERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ----DEPNFVLAG 115 +C Q + Q + ARALMV S + + A +G++C + A Sbjct: 61 IYQC-QIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAI 119 Query: 116 LSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGF 175 L G + +AGLL ++ VSW + + P S + ++ +L LG++ S L L+GG Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179 Query: 176 SLALSFAPWCDERCRRRRKGPSAGPRRSSVST 207 L LS C + R P P R++ +T Sbjct: 180 LLCLS----CQDEAPYR---PYQAPPRATTTT 204 >gi|225703138 claudin 14 [Homo sapiens] Length = 239 Score = 67.4 bits (163), Expect = 1e-11 Identities = 60/212 (28%), Positives = 94/212 (44%), Gaps = 13/212 (6%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGF-LNQPVDVELYQGLWDMCREQSSR 59 M + V LG +L+ G++ L T+ P WR N V +GLW C S+ Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60 Query: 60 ERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ----DEPNFVLAG 115 +C Q + Q + ARALMV S + + A +G++C + A Sbjct: 61 IYQC-QIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAI 119 Query: 116 LSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGF 175 L G + +AGLL ++ VSW + + P S + ++ +L LG++ S L L+GG Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179 Query: 176 SLALSFAPWCDERCRRRRKGPSAGPRRSSVST 207 L LS C + R P P R++ +T Sbjct: 180 LLCLS----CQDEAPYR---PYQAPPRATTTT 204 >gi|6912314 claudin 14 [Homo sapiens] Length = 239 Score = 67.4 bits (163), Expect = 1e-11 Identities = 60/212 (28%), Positives = 94/212 (44%), Gaps = 13/212 (6%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGF-LNQPVDVELYQGLWDMCREQSSR 59 M + V LG +L+ G++ L T+ P WR N V +GLW C S+ Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60 Query: 60 ERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ----DEPNFVLAG 115 +C Q + Q + ARALMV S + + A +G++C + A Sbjct: 61 IYQC-QIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAI 119 Query: 116 LSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGF 175 L G + +AGLL ++ VSW + + P S + ++ +L LG++ S L L+GG Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179 Query: 176 SLALSFAPWCDERCRRRRKGPSAGPRRSSVST 207 L LS C + R P P R++ +T Sbjct: 180 LLCLS----CQDEAPYR---PYQAPPRATTTT 204 >gi|225703140 claudin 14 [Homo sapiens] Length = 239 Score = 67.4 bits (163), Expect = 1e-11 Identities = 60/212 (28%), Positives = 94/212 (44%), Gaps = 13/212 (6%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGF-LNQPVDVELYQGLWDMCREQSSR 59 M + V LG +L+ G++ L T+ P WR N V +GLW C S+ Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60 Query: 60 ERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ----DEPNFVLAG 115 +C Q + Q + ARALMV S + + A +G++C + A Sbjct: 61 IYQC-QIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAI 119 Query: 116 LSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGF 175 L G + +AGLL ++ VSW + + P S + ++ +L LG++ S L L+GG Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGT 179 Query: 176 SLALSFAPWCDERCRRRRKGPSAGPRRSSVST 207 L LS C + R P P R++ +T Sbjct: 180 LLCLS----CQDEAPYR---PYQAPPRATTTT 204 >gi|10863887 claudin 1 [Homo sapiens] Length = 211 Score = 67.0 bits (162), Expect = 2e-11 Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 15/182 (8%) Query: 9 LGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE-LYQGLWDMCREQSSRERECGQTD 67 LG +LA G + + T P WR+ + V + +Y+GLW C QS+ + +C D Sbjct: 9 LGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFD 68 Query: 68 QWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ-----DEPNFVLAGLSGVVLF 122 + + RALMV + V+ + +A++G++C + + +A + G + Sbjct: 69 SLLNLSST-LQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFL 127 Query: 123 VAGLLGLIPVSWYNHFLGDRDV--LPAPASPVTVQVSY--SLVLGYLGSCLLLLGGFSLA 178 +AGL L+ +WY G+R V P +PV + + +L G+ + L LLGG L Sbjct: 128 LAGLAILVATAWY----GNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLC 183 Query: 179 LS 180 S Sbjct: 184 CS 185 >gi|4502875 claudin 3 [Homo sapiens] Length = 220 Score = 66.2 bits (160), Expect = 3e-11 Identities = 52/180 (28%), Positives = 81/180 (45%), Gaps = 8/180 (4%) Query: 10 GMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPV--DVELYQGLWDMCREQSSRERECGQTD 67 G LA G L + P WR V F+ + +++GLW C QS+ + +C D Sbjct: 9 GTALAVLGWLGTIVCCALPMWR-VSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYD 67 Query: 68 QWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRC----WQDEPNFVLAGLSGVVLFV 123 Q + ARAL+V ++ GLL+A +G +C D + ++GV+ + Sbjct: 68 SLLALP-QDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLL 126 Query: 124 AGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSFAP 183 A LL L+PVSW + + P ++ L +G+ + L LLGG L S P Sbjct: 127 AALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPP 186 >gi|6912316 claudin 17 [Homo sapiens] Length = 224 Score = 66.2 bits (160), Expect = 3e-11 Identities = 58/194 (29%), Positives = 91/194 (46%), Gaps = 17/194 (8%) Query: 10 GMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDV--ELYQGLWDMCREQSSRERECGQTD 67 G+VL G++ L TL P WR V F+ + V L++GLW C Q+ +C Sbjct: 10 GLVLGFLGMVGTLATTLLPQWR-VSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYS 68 Query: 68 QWGYFEAQPVL-VARALMVTSLAATVLGLLLASLGVRCWQ-----DEPNFVLAGLSGVVL 121 P L ARALM ++A +++ LL+ G++ Q + L G SGV+ Sbjct: 69 S--LLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLF 126 Query: 122 FVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSF 181 + G+ LIPVSW + + PA ++ +L LG+ + +L +GG L F Sbjct: 127 ILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGG-GLLCGF 185 Query: 182 APWCDERCRRRRKG 195 C C R+++G Sbjct: 186 C--C---CNRKKQG 194 >gi|7656981 claudin 15 [Homo sapiens] Length = 228 Score = 66.2 bits (160), Expect = 3e-11 Identities = 60/216 (27%), Positives = 90/216 (41%), Gaps = 26/216 (12%) Query: 6 VMTLGMVLAPCGLLLNLTGTLAPG--WRLVKGFLNQPVDVELYQGLWDMCREQSSREREC 63 V T G +A GLL+ G P WR+ N +++ LW C S C Sbjct: 5 VETFGFFMATVGLLM--LGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNC 62 Query: 64 GQTDQW----GYFEAQPVLVARALMVTSLAATVLGLLLASLGVRC-----WQDEPNFVLA 114 + GY +A RALM+T++ LGLLL G+RC + LA Sbjct: 63 WEFPSMLALSGYIQA-----CRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLA 117 Query: 115 GLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 +G + +AG+ G++ +SWY F RD ++ +L LG+ S + +LGG Sbjct: 118 ATAGALHILAGICGMVAISWY-AFNITRDFFDPLYPGTKYELGPALYLGWSASLISILGG 176 Query: 175 FSLALSFAPWCDERCRRRRKGPSAGPRRSSVSTIQV 210 L C C + P+A RR + + V Sbjct: 177 LCL-------CSACCCGSDEDPAASARRPYQAPVSV 205 >gi|9966781 claudin 2 [Homo sapiens] Length = 230 Score = 64.3 bits (155), Expect = 1e-10 Identities = 50/180 (27%), Positives = 80/180 (44%), Gaps = 12/180 (6%) Query: 9 LGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPV--DVELYQGLWDMCREQSSRERECGQT 66 +G +L GLL L L P W+ ++ + V +GLW C S+ +C Sbjct: 9 VGYILGLLGLLGTLVAMLLPSWK-TSSYVGASIVTAVGFSKGLWMECATHSTGITQC--- 64 Query: 67 DQWGYFEAQP--VLVARALMVTSLAATVLGLLLASLGVRCW----QDEPNFVLAGLSGVV 120 D + P + A+A+MVTS A + L +++ +G+RC + +A GV Sbjct: 65 DIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVF 124 Query: 121 LFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALS 180 + GLLG IPV+W H + P + ++ +L LG + S L+ G L S Sbjct: 125 FILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFS 184 >gi|183979973 claudin 19 isoform a [Homo sapiens] Length = 224 Score = 60.8 bits (146), Expect = 1e-09 Identities = 59/210 (28%), Positives = 94/210 (44%), Gaps = 19/210 (9%) Query: 9 LGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPV--DVELYQGLWDMCREQSSRERECGQT 66 LG LA G + + T P W+ + + V LY+GLW C QS+ + +C Sbjct: 9 LGYFLALGGWVGIIASTALPQWKQ-SSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLY 67 Query: 67 DQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ-DEPNFVLAG---LSGVVLF 122 D + + ARALMV ++ + ++L+ +G++C + + N + G ++G LF Sbjct: 68 DSLLALDGH-IQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALF 126 Query: 123 V-AGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSF 181 + AGL L VSWY + P+ + +L +G+ + L +LGG L + Sbjct: 127 ILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLCCT- 185 Query: 182 APWCDERCRRR------RKGPSAGPRRSSV 205 C E R R GPSA R V Sbjct: 186 ---CPEPERPNSSPQPYRPGPSAAAREPVV 212 >gi|183979975 claudin 19 isoform b [Homo sapiens] Length = 211 Score = 60.5 bits (145), Expect = 2e-09 Identities = 58/206 (28%), Positives = 93/206 (45%), Gaps = 19/206 (9%) Query: 9 LGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPV--DVELYQGLWDMCREQSSRERECGQT 66 LG LA G + + T P W+ + + V LY+GLW C QS+ + +C Sbjct: 9 LGYFLALGGWVGIIASTALPQWKQ-SSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLY 67 Query: 67 DQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ-DEPNFVLAG---LSGVVLF 122 D + + ARALMV ++ + ++L+ +G++C + + N + G ++G LF Sbjct: 68 DSLLALDGH-IQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALF 126 Query: 123 V-AGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSF 181 + AGL L VSWY + P+ + +L +G+ + L +LGG L + Sbjct: 127 ILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLCCT- 185 Query: 182 APWCDERCRRR------RKGPSAGPR 201 C E R R GPSA R Sbjct: 186 ---CPEPERPNSSPQPYRPGPSAAAR 208 >gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 59.3 bits (142), Expect = 4e-09 Identities = 50/178 (28%), Positives = 83/178 (46%), Gaps = 15/178 (8%) Query: 6 VMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQ 65 + ++G++L+ G +L++ T P W+ + LN+ + + GLW C Q +C Sbjct: 9 MQSVGLLLSLLGWILSIITTYLPHWKNLNLDLNEMENWTM--GLWQTCVIQEEVGMQCKD 66 Query: 66 TDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW-----QDEPNFVLAGLSGVV 120 D + A+ + V+R LM S LGLL++ G+ C Q + L L G++ Sbjct: 67 FDSFLALPAE-LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGIL 125 Query: 121 LFVAGLLGLIPVSWYNH----FLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 + +G+ L+PVSW H D +V P + +L LG+ LLLGG Sbjct: 126 SWASGITALVPVSWVAHKTVQEFWDENV---PDFVPRWEFGEALFLGWFAGLSLLLGG 180 >gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 58.9 bits (141), Expect = 5e-09 Identities = 50/178 (28%), Positives = 83/178 (46%), Gaps = 15/178 (8%) Query: 6 VMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQ 65 + ++G++L+ G +L++ T P W+ + LN+ + + GLW C Q +C Sbjct: 9 MQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWTM--GLWQTCVIQEEVGMQCKD 66 Query: 66 TDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW-----QDEPNFVLAGLSGVV 120 D + A+ + V+R LM S LGLL++ G+ C Q + L L G++ Sbjct: 67 FDSFLALPAE-LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGIL 125 Query: 121 LFVAGLLGLIPVSWYNH----FLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 + +G+ L+PVSW H D +V P + +L LG+ LLLGG Sbjct: 126 SWASGITALVPVSWVAHKTVQEFWDENV---PDFVPRWEFGEALFLGWFAGLSLLLGG 180 >gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 58.9 bits (141), Expect = 5e-09 Identities = 50/178 (28%), Positives = 83/178 (46%), Gaps = 15/178 (8%) Query: 6 VMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQ 65 + ++G++L+ G +L++ T P W+ + LN+ + + GLW C Q +C Sbjct: 9 MQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWTM--GLWQTCVIQEEVGMQCKD 66 Query: 66 TDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW-----QDEPNFVLAGLSGVV 120 D + A+ + V+R LM S LGLL++ G+ C Q + L L G++ Sbjct: 67 FDSFLALPAE-LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGIL 125 Query: 121 LFVAGLLGLIPVSWYNH----FLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 + +G+ L+PVSW H D +V P + +L LG+ LLLGG Sbjct: 126 SWASGITALVPVSWVAHKTVQEFWDENV---PDFVPRWEFGEALFLGWFAGLSLLLGG 180 >gi|40788011 claudin 8 [Homo sapiens] Length = 225 Score = 57.0 bits (136), Expect = 2e-08 Identities = 49/197 (24%), Positives = 92/197 (46%), Gaps = 15/197 (7%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDV--ELYQGLWDMCREQSS 58 M T + G+ L G++ + T+ P WR V F+ + V ++GLW C Q++ Sbjct: 1 MATHALEIAGLFLGGVGMVGTVAVTVMPQWR-VSAFIENNIVVFENFWEGLWMNCVRQAN 59 Query: 59 RERECGQTDQWGYFEAQPVL-VARALMVTSLAATVLGLLLASLGVRCWQ-----DEPNFV 112 +C D P L AR LM + + L ++A LG++C + ++ Sbjct: 60 IRMQCKIYDS--LLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAH 117 Query: 113 LAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTV-QVSYSLVLGYLGSCLLL 171 + +G++ + G++ LIPVSW + + RD + + ++ +L LG+ + +L+ Sbjct: 118 ILLTAGIIFIITGMVVLIPVSWVANAI-IRDFYNSIVNVAQKRELGEALYLGWTTALVLI 176 Query: 172 LGGFSLALSFAPWCDER 188 +GG F C+E+ Sbjct: 177 VGGALFCCVFC--CNEK 191 >gi|50345279 claudin 18 isoform 2 [Homo sapiens] Length = 261 Score = 55.8 bits (133), Expect = 4e-08 Identities = 50/192 (26%), Positives = 84/192 (43%), Gaps = 25/192 (13%) Query: 9 LGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQTDQ 68 LG V++ G+ + T W + N V YQGLW C +SS EC Sbjct: 9 LGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECR---- 64 Query: 69 WGYFE--AQPVLV--ARALMVTSLAATVLGLLLASLGVRC-----WQDEPNFVLAGLSGV 119 GYF P ++ RALM+ + +GLL++ ++C +D + SG+ Sbjct: 65 -GYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGI 123 Query: 120 VLFVAGLLGLIPVSWY------NHFLGDRDVLPAPASPV-TVQVSY----SLVLGYLGSC 168 + V+GL + VS + N ++ ++ V TVQ Y +L +G++ Sbjct: 124 MFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGG 183 Query: 169 LLLLGGFSLALS 180 L L+GG + ++ Sbjct: 184 LTLIGGVMMCIA 195 >gi|157820127 claudin-like [Homo sapiens] Length = 229 Score = 54.3 bits (129), Expect = 1e-07 Identities = 55/184 (29%), Positives = 83/184 (45%), Gaps = 23/184 (12%) Query: 10 GMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELY-QGLWDMCREQSSRERECGQTDQ 68 G++L+ G + + T+ P W+ + LN+ +E + G+W++C ++ C + Sbjct: 13 GLLLSLLGWVCSCVTTILPQWKTLNLELNE---METWIMGIWEVCVDREEVATVCKAFES 69 Query: 69 WGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ-DEPNFVL---AGLSGVVLFV- 123 + Q + VAR LMV S +LGLLL S G C+Q +V GL G L Sbjct: 70 FLSLP-QELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGLLGRTLEAS 128 Query: 124 AGLLGLIPVSWYNH-----FLGDR--DVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFS 176 A L+PVSW H F D D++P + +L LG+ L LGG Sbjct: 129 ASATTLLPVSWVAHATIQDFWDDSIPDIIP------RWEFGGALYLGWAAGIFLALGGLL 182 Query: 177 LALS 180 L S Sbjct: 183 LIFS 186 >gi|162417973 claudin 22 [Homo sapiens] Length = 220 Score = 53.5 bits (127), Expect = 2e-07 Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 15/179 (8%) Query: 5 VVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECG 64 V G+ L+ G +L+ P W+ + LN+ + + GLW C Q +C Sbjct: 8 VAQLAGVSLSLLGWVLSCLTNYLPHWKNLNLDLNEMENWTM--GLWQTCVIQEEVGMQCK 65 Query: 65 QTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW-----QDEPNFVLAGLSGV 119 D + A+ + V+R LM S LGLL++ G+ C Q + L L G+ Sbjct: 66 DFDSFLALPAE-LRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGI 124 Query: 120 VLFVAGLLGLIPVSWYNH----FLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 + + +G+ L+PVSW H D +V P + +L LG+ LLLGG Sbjct: 125 LSWASGVTALVPVSWVAHKTVQEFWDENV---PDFVPRWEFGEALFLGWFAGLSLLLGG 180 >gi|195947374 claudin 5 [Homo sapiens] Length = 303 Score = 52.4 bits (124), Expect = 5e-07 Identities = 46/171 (26%), Positives = 79/171 (46%), Gaps = 18/171 (10%) Query: 10 GMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE--LYQGLWDMCREQSSRERECGQTD 67 G++LA CGL P W+ V FL+ + ++GLW C QS+ +C D Sbjct: 105 GLILA-CGL---------PMWQ-VTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYD 153 Query: 68 QWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ---DEPNFVLAGLSGVVLFV- 123 + V ARAL V+++ + L + G +C P L+G VL++ Sbjct: 154 SVLALSTE-VQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYLF 212 Query: 124 AGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 GLL L+P+ W+ + + P+ ++ +L +G+ + LL++GG Sbjct: 213 CGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGG 263 >gi|195947372 claudin 5 [Homo sapiens] Length = 303 Score = 52.4 bits (124), Expect = 5e-07 Identities = 46/171 (26%), Positives = 79/171 (46%), Gaps = 18/171 (10%) Query: 10 GMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE--LYQGLWDMCREQSSRERECGQTD 67 G++LA CGL P W+ V FL+ + ++GLW C QS+ +C D Sbjct: 105 GLILA-CGL---------PMWQ-VTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYD 153 Query: 68 QWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQ---DEPNFVLAGLSGVVLFV- 123 + V ARAL V+++ + L + G +C P L+G VL++ Sbjct: 154 SVLALSTE-VQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYLF 212 Query: 124 AGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGG 174 GLL L+P+ W+ + + P+ ++ +L +G+ + LL++GG Sbjct: 213 CGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGG 263 >gi|7705961 claudin 18 isoform 1 [Homo sapiens] Length = 261 Score = 52.4 bits (124), Expect = 5e-07 Identities = 50/200 (25%), Positives = 84/200 (42%), Gaps = 25/200 (12%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRE 60 M T + +L+ GL + T W + N V Y+GLW C QSS Sbjct: 1 MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGF 60 Query: 61 RECGQTDQWGYFE--AQPVLV--ARALMVTSLAATVLGLLLASLGVRC-----WQDEPNF 111 EC YF P ++ RALM+ + +GLL++ ++C +D Sbjct: 61 TECRP-----YFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKA 115 Query: 112 VLAGLSGVVLFVAGLLGLIPVSWY------NHFLGDRDVLPAPASPV-TVQVSY----SL 160 + SG++ V+GL + VS + N ++ ++ V TVQ Y +L Sbjct: 116 NMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAAL 175 Query: 161 VLGYLGSCLLLLGGFSLALS 180 +G++ L L+GG + ++ Sbjct: 176 FVGWVAGGLTLIGGVMMCIA 195 >gi|47716519 claudin 20 [Homo sapiens] Length = 219 Score = 49.3 bits (116), Expect = 4e-06 Identities = 58/224 (25%), Positives = 95/224 (42%), Gaps = 29/224 (12%) Query: 1 MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELY------QGLWDMCR 54 M + + L +LA G+ LT TL P W++ N VD + GLW C Sbjct: 1 MASAGLQLLAFILALSGVSGVLTATLLPNWKV-----NVDVDSNIITAIVQLHGLWMDCT 55 Query: 55 EQSSRERECGQTDQWGYFEAQPVLV--ARALMVTSLAATVLGLLLASLGVRCWQ---DEP 109 S+ C + P+ V ARA MV + + LG+ +++G++C + D Sbjct: 56 WYSTGMFSCALKHS---ILSLPIHVQAARATMVLACVLSALGICTSTVGMKCTRLGGDRE 112 Query: 110 NFVLAGLSGVVLFV-AGLLGLIPVSWY-NHFLGDRDVLPAPASPVTVQVSYSLVLGYLGS 167 A +G V F+ AG+ LI WY + + L P S + ++ +G++ + Sbjct: 113 TKSHASFAGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPESN-KHEPGGAIYIGFISA 171 Query: 168 CLLLLGGFSLALSFAPWCDERCRRRRKGPSAGPRRSSVSTIQVE 211 LL + G + F C +R R P P + +S Q+E Sbjct: 172 MLLFISG----MIFCTSCIKRNPEARLDP---PTQQPISNTQLE 208 >gi|33598916 claudin 10 isoform a [Homo sapiens] Length = 226 Score = 43.5 bits (101), Expect = 2e-04 Identities = 35/147 (23%), Positives = 66/147 (44%), Gaps = 16/147 (10%) Query: 45 LYQGLWDMCREQSSRERECGQTDQWGYFEAQPVLVA-RALMVTSLAATVLGLLLASLGVR 103 +YQGLW C + C + F+ + A R LM+ +++ G + A G++ Sbjct: 43 VYQGLWMNCAGNALGSFHC--RPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMK 100 Query: 104 CWQ----DEPNFVLAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSY- 158 C + D+ +A L+G+V ++GL + S Y + + P+ V+ Y Sbjct: 101 CTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYAN-----KITTEFFDPLFVEQKYE 155 Query: 159 ---SLVLGYLGSCLLLLGGFSLALSFA 182 +L +G+ G+ L ++GG S + Sbjct: 156 LGAALFIGWAGASLCIIGGVIFCFSIS 182 >gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] Length = 207 Score = 42.7 bits (99), Expect = 4e-04 Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 33/146 (22%) Query: 45 LYQGLWDMCREQSSRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRC 104 +YQGLW C GY +A R LM+ +++ G + A G++C Sbjct: 43 VYQGLWMNCA---------------GYIQA-----CRGLMIAAVSLGFFGSIFALFGMKC 82 Query: 105 WQ----DEPNFVLAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSY-- 158 + D+ +A L+G+V ++GL + S Y + + P+ V+ Y Sbjct: 83 TKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYAN-----KITTEFFDPLFVEQKYEL 137 Query: 159 --SLVLGYLGSCLLLLGGFSLALSFA 182 +L +G+ G+ L ++GG S + Sbjct: 138 GAALFIGWAGASLCIIGGVIFCFSIS 163 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.139 0.452 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,573,834 Number of Sequences: 37866 Number of extensions: 777179 Number of successful extensions: 3513 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 43 Number of HSP's successfully gapped in prelim test: 93 Number of HSP's that attempted gapping in prelim test: 3309 Number of HSP's gapped (non-prelim): 233 length of query: 292 length of database: 18,247,518 effective HSP length: 101 effective length of query: 191 effective length of database: 14,423,052 effective search space: 2754802932 effective search space used: 2754802932 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.