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Search of human proteins with 38045942
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo
sapiens]
(463 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] 942 0.0
gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] 907 0.0
gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] 160 2e-39
gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] 117 2e-26
gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] 117 2e-26
gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] 117 2e-26
gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sa... 106 4e-23
gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] 57 4e-08
gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo s... 56 8e-08
gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo s... 56 8e-08
gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 56 8e-08
gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 56 8e-08
gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo... 49 7e-06
gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo ... 49 7e-06
gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] 48 2e-05
gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] 47 5e-05
gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] 45 2e-04
gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] 45 2e-04
gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] 45 2e-04
gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Hom... 32 1.2
gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Hom... 32 1.2
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 32 1.6
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 32 1.6
gi|70887790 DNA-directed DNA polymerase gamma 2 [Homo sapiens] 31 2.1
gi|158508542 kelch-like 33 [Homo sapiens] 31 2.7
gi|153792780 additional sex combs like 2 [Homo sapiens] 30 3.5
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 30 4.6
gi|5454132 tumor necrosis factor, alpha-induced protein 3 [Homo ... 30 6.0
gi|11225260 DNA topoisomerase I [Homo sapiens] 29 7.9
gi|197927446 sarcosine dehydrogenase precursor [Homo sapiens] 29 7.9
>gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens]
Length = 463
Score = 942 bits (2435), Expect = 0.0
Identities = 463/463 (100%), Positives = 463/463 (100%)
Query: 1 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 60
MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST
Sbjct: 1 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 60
Query: 61 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 120
ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI
Sbjct: 61 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 120
Query: 121 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 180
GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI
Sbjct: 121 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 180
Query: 181 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 240
SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA
Sbjct: 181 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 240
Query: 241 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 300
SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR
Sbjct: 241 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 300
Query: 301 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 360
LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER
Sbjct: 301 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 360
Query: 361 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 420
KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS
Sbjct: 361 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 420
Query: 421 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 463
IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS
Sbjct: 421 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 463
>gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens]
Length = 449
Score = 907 bits (2344), Expect = 0.0
Identities = 449/463 (96%), Positives = 449/463 (96%), Gaps = 14/463 (3%)
Query: 1 MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 60
MADGEEP MAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST
Sbjct: 1 MADGEEP--------------MAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST 46
Query: 61 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 120
ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI
Sbjct: 47 ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI 106
Query: 121 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 180
GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI
Sbjct: 107 GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI 166
Query: 181 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 240
SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA
Sbjct: 167 SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA 226
Query: 241 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 300
SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR
Sbjct: 227 SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR 286
Query: 301 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 360
LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER
Sbjct: 287 LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 346
Query: 361 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 420
KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS
Sbjct: 347 KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS 406
Query: 421 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 463
IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS
Sbjct: 407 IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS 449
>gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens]
Length = 640
Score = 160 bits (406), Expect = 2e-39
Identities = 99/236 (41%), Positives = 135/236 (57%), Gaps = 19/236 (8%)
Query: 71 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAE 130
+VLV+GAGG+GCELLKNL L+GF I +ID+DTIDVSNLNRQFLF+ K +GR KA+VA E
Sbjct: 19 RVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKE 78
Query: 131 FLNDRVPNCNVVPHFNKIQ--DFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDG 188
+ P N+V + + I D+N F+RQF +++ LD+ AR +N M +
Sbjct: 79 SVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCL-------- 130
Query: 189 VLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEH 248
++ VPLI+ GT G+ G I G+T C EC + P Q FP CTI + P P H
Sbjct: 131 ----AADVPLIESGTAGYLGQVTTIKKGVTECYECHPK--PTQRTFPGCTIRNTPSEPIH 184
Query: 249 CIEYVRML--QWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLT 302
CI + + L Q E+ + V D DPE W ++ RA N G R++
Sbjct: 185 CIVWAKYLFNQLFGEEDADQEVSPDRADPE-AAWEPTEAEARARASNEDGDIKRIS 239
Score = 41.2 bits (95), Expect = 0.002
Identities = 54/227 (23%), Positives = 87/227 (38%), Gaps = 15/227 (6%)
Query: 239 IASMPRLPEHCIEYVRMLQWPKEQPFGEGVPL--DGDDPEHIQWIFQKSLERASQYNIRG 296
+ S RL IE +R+ K G+G L D DDP + ++ + R +++
Sbjct: 315 VKSYARLFSKSIETLRVHLAEK----GDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM 370
Query: 297 VTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVF---NDVDGLYT 353
+ + + IIPA+A+TNAVIA + E KI + + N L
Sbjct: 371 KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLV 430
Query: 354 YTFEAERKENCPACSQLPQ-NIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRT 412
NC C+ P+ ++ + L M +P + +GK
Sbjct: 431 PCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIE-DGKGTI 489
Query: 413 LYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKL 459
L ++S E T N K L E G+ +G L D T+L +
Sbjct: 490 L----ISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINI 532
>gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 117 bits (293), Expect = 2e-26
Identities = 68/202 (33%), Positives = 110/202 (54%), Gaps = 24/202 (11%)
Query: 63 LQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-----QIHVIDMDTIDVSNLNRQFLFRP 117
LQ L K ++GAG +GCELLKN A+ G +I V DMDTI+ SNLNRQFLFRP
Sbjct: 462 LQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRP 521
Query: 118 KDIGRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIAR 172
D+ + K++ AA + P+ V H N++ + ++D F++ + LD++ AR
Sbjct: 522 WDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDAR 581
Query: 173 RWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 232
+++ + PL++ GT G KGN +V++P +T + + PP+
Sbjct: 582 MYMDRRCVYYRK------------PLLESGTLGTKGNVQVVIPFLTESYSSSQD--PPEK 627
Query: 233 NFPMCTIASMPRLPEHCIEYVR 254
+ P+CT+ + P EH +++ R
Sbjct: 628 SIPICTLKNFPNAIEHTLQWAR 649
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 5/75 (6%)
Query: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126
L T VLV G GLG E+ KN+ L G + + + D T ++L+ QF R +DIG+ +AE
Sbjct: 70 LQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAE 129
Query: 127 VA----AEFLNDRVP 137
V+ AE LN VP
Sbjct: 130 VSQPRLAE-LNSYVP 143
Score = 37.4 bits (85), Expect = 0.029
Identities = 18/61 (29%), Positives = 32/61 (52%)
Query: 271 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 330
D D H+ +I S RA Y+I ++ + +IIPA+A+T A + + E++K
Sbjct: 852 DDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYK 911
Query: 331 I 331
+
Sbjct: 912 V 912
>gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 117 bits (293), Expect = 2e-26
Identities = 68/202 (33%), Positives = 110/202 (54%), Gaps = 24/202 (11%)
Query: 63 LQFLLDTCKVLVIGAGGLGCELLKNLALSGFR-----QIHVIDMDTIDVSNLNRQFLFRP 117
LQ L K ++GAG +GCELLKN A+ G +I V DMDTI+ SNLNRQFLFRP
Sbjct: 462 LQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRP 521
Query: 118 KDIGRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIAR 172
D+ + K++ AA + P+ V H N++ + ++D F++ + LD++ AR
Sbjct: 522 WDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDAR 581
Query: 173 RWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 232
+++ + PL++ GT G KGN +V++P +T + + PP+
Sbjct: 582 MYMDRRCVYYRK------------PLLESGTLGTKGNVQVVIPFLTESYSSSQD--PPEK 627
Query: 233 NFPMCTIASMPRLPEHCIEYVR 254
+ P+CT+ + P EH +++ R
Sbjct: 628 SIPICTLKNFPNAIEHTLQWAR 649
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/75 (42%), Positives = 44/75 (58%), Gaps = 5/75 (6%)
Query: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126
L T VLV G GLG E+ KN+ L G + + + D T ++L+ QF R +DIG+ +AE
Sbjct: 70 LQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAE 129
Query: 127 VA----AEFLNDRVP 137
V+ AE LN VP
Sbjct: 130 VSQPRLAE-LNSYVP 143
Score = 37.4 bits (85), Expect = 0.029
Identities = 18/61 (29%), Positives = 32/61 (52%)
Query: 271 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 330
D D H+ +I S RA Y+I ++ + +IIPA+A+T A + + E++K
Sbjct: 852 DDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYK 911
Query: 331 I 331
+
Sbjct: 912 V 912
>gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens]
Length = 1052
Score = 117 bits (293), Expect = 2e-26
Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 25/199 (12%)
Query: 67 LDTCKVLVIGAGGLGCELLKNLALSGFR------QIHVIDMDTIDVSNLNRQFLFRPKDI 120
L + ++G G +GCE+LKN AL G I V D D I+ SNLNRQFLFRP I
Sbjct: 458 LQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHI 517
Query: 121 GRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIARRWI 175
+PK+ AA+ + H NK+ +ND FY + +I+ LD++ ARR++
Sbjct: 518 QKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYV 577
Query: 176 NGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFP 235
+ ++ L PL+D GT G KG+ VI+P +T + PP+ P
Sbjct: 578 DSRCLANLR------------PLLDSGTMGTKGHTEVIVPHLTESYNSHRD--PPEEEIP 623
Query: 236 MCTIASMPRLPEHCIEYVR 254
CT+ S P EH I++ R
Sbjct: 624 FCTLKSFPAAIEHTIQWAR 642
Score = 40.0 bits (92), Expect = 0.004
Identities = 21/61 (34%), Positives = 33/61 (54%)
Query: 271 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 330
D D HI +I S RA Y+I T+ + +IIPA+A+T A ++ + A E+ K
Sbjct: 852 DDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIK 911
Query: 331 I 331
+
Sbjct: 912 V 912
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 72 VLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI--GRPKAEVAA 129
V + G GGLG E+ KNL L+G + + + D + +L F D+ R +AE
Sbjct: 64 VFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVL 123
Query: 130 EFLNDRVPNCNV----VPHFNKIQDFN 152
+ + + P +V VP FN+ D +
Sbjct: 124 KHIAELNPYVHVTSSSVP-FNETTDLS 149
>gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo
sapiens]
Length = 1012
Score = 106 bits (265), Expect = 4e-23
Identities = 66/193 (34%), Positives = 96/193 (49%), Gaps = 23/193 (11%)
Query: 73 LVIGAGGLGCELLKNLALSGFRQ-----IHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEV 127
L++GAG +GCELLK AL G + V+DMD I+ SNL+RQFLFR +D+GRPKAEV
Sbjct: 436 LLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEV 495
Query: 128 AAEFLNDRVPNCNVVPHFNKIQD-----FNDTFYRQFHIIVCGLDSIIARRWINGMLISL 182
AA P+ V+P + + D F+ + + LDS ARR++
Sbjct: 496 AAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQARRYVAARCTHY 555
Query: 183 LNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQ-VNFPMCTIAS 241
L PL++ GT G G+A V +P +T + +P+CT+
Sbjct: 556 LK------------PLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRY 603
Query: 242 MPRLPEHCIEYVR 254
P EH +++ R
Sbjct: 604 FPSTAEHTLQWAR 616
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 3/93 (3%)
Query: 71 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAE 130
+VLV G GLG E+ KNL L G + + D S+L QFL +D+ R +AE + E
Sbjct: 34 RVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAAQFLLSEQDLERSRAEASQE 93
Query: 131 FLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIV 163
L VV H D + F ++V
Sbjct: 94 LLAQLNRAVQVVVHTG---DITEDLLLDFQVVV 123
Score = 39.7 bits (91), Expect = 0.006
Identities = 18/63 (28%), Positives = 34/63 (53%)
Query: 271 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 330
D D H+ ++ + R Y I V ++ +V +IIPA+A+T A +A + E++K
Sbjct: 811 DDDSNFHVDFVVAAASLRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYK 870
Query: 331 IAT 333
+ +
Sbjct: 871 VVS 873
>gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens]
Length = 460
Score = 57.0 bits (136), Expect = 4e-08
Identities = 45/175 (25%), Positives = 69/175 (39%), Gaps = 13/175 (7%)
Query: 64 QFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRP 123
Q L T VL++G GGLGC L + LA +G ++ ++D D +++SNL RQ L G+
Sbjct: 77 QLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQA 136
Query: 124 KAEVAAEFLNDRVPNCNVVPHFNKIQDFND-TFYRQFHIIVCGLDSIIARRWINGMLISL 182
KA AA L VP+ + R++ ++ D++ R +N +
Sbjct: 137 KAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLA 196
Query: 183 LNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMC 237
PL+ F+G V C C PP C
Sbjct: 197 GR------------PLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNC 239
>gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo
sapiens]
Length = 266
Score = 55.8 bits (133), Expect = 8e-08
Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126
L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE
Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93
Query: 127 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 170
+ E + P +V I+ ++F+ QF + C D I+
Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140
>gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo
sapiens]
Length = 299
Score = 55.8 bits (133), Expect = 8e-08
Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126
L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE
Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93
Query: 127 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 170
+ E + P +V I+ ++F+ QF + C D I+
Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140
>gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 55.8 bits (133), Expect = 8e-08
Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126
L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE
Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93
Query: 127 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 170
+ E + P +V I+ ++F+ QF + C D I+
Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140
>gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 55.8 bits (133), Expect = 8e-08
Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126
L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE
Sbjct: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93
Query: 127 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 170
+ E + P +V I+ ++F+ QF + C D I+
Sbjct: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140
>gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo
sapiens]
Length = 528
Score = 49.3 bits (116), Expect = 7e-06
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 64 QFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRP 123
Q L++ V +I A G E+LKNL L G +ID + + + F + IG+
Sbjct: 19 QEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKN 78
Query: 124 KAEVAAEF---LNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIV 163
+AE A EF LN V V + D + +F+ +F ++V
Sbjct: 79 RAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVV 121
>gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo
sapiens]
Length = 534
Score = 49.3 bits (116), Expect = 7e-06
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 64 QFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRP 123
Q L++ V +I A G E+LKNL L G +ID + + + F + IG+
Sbjct: 25 QEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKN 84
Query: 124 KAEVAAEF---LNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIV 163
+AE A EF LN V V + D + +F+ +F ++V
Sbjct: 85 RAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVV 127
>gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens]
Length = 404
Score = 47.8 bits (112), Expect = 2e-05
Identities = 61/258 (23%), Positives = 104/258 (40%), Gaps = 56/258 (21%)
Query: 5 EEPEKKRRRIEEL---LAEKMAVD-GGCGDTGDWEGRWNHVKKFLERSGPFTH------- 53
E E+ ++R++EL LA++ ++ GD G R + + S P++
Sbjct: 3 ESVERLQQRVQELERELAQERSLQVPRSGDGGGGRVRIEKMSSEVVDSNPYSRLMALKRM 62
Query: 54 ---PDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLN 110
D+E + T V ++G GG+G + L G ++ + D D ++++N+N
Sbjct: 63 GIVSDYEK--------IRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMN 114
Query: 111 RQFLFRPKDIGRPKAEVAAEFLND-------RVPNCNVVPHFNKIQDFNDTFY------- 156
R F F+P G K + A L + V N N+ N Q F D
Sbjct: 115 RLF-FQPHQAGLSKVQAAEHTLRNINPDVLFEVHNYNITTVEN-FQHFMDRISNGGLEEG 172
Query: 157 RQFHIIVCGLDSIIARRWINGMLISLLN--YEDGVLDPSSIVPLIDGGTEGFKGNARVIL 214
+ +++ +D+ AR IN L E GV + G+ ++I+
Sbjct: 173 KPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSE------------NAVSGHIQLII 220
Query: 215 PGMTACIECTLELYPPQV 232
PG +AC C PP V
Sbjct: 221 PGESACFACA----PPLV 234
>gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens]
Length = 348
Score = 46.6 bits (109), Expect = 5e-05
Identities = 46/180 (25%), Positives = 74/180 (41%), Gaps = 34/180 (18%)
Query: 69 TCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVA 128
T V ++G GG+G + L G ++ + D D ++++N+NR F F+P G K + A
Sbjct: 17 TFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAA 75
Query: 129 AEFLND-------RVPNCNVVPHFNKIQDFNDTFY-------RQFHIIVCGLDSIIARRW 174
L + V N N+ N Q F D + +++ +D+ AR
Sbjct: 76 EHTLRNINPDVLFEVHNYNITTVEN-FQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMT 134
Query: 175 INGMLISLLN--YEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQV 232
IN L E GV + G+ ++I+PG +AC C PP V
Sbjct: 135 INTACNELGQTWMESGVSE------------NAVSGHIQLIIPGESACFACA----PPLV 178
>gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens]
Length = 623
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 71 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI---GRPKAEV 127
K L++GAG LGC + + L G R I +D I SN RQ L+ +D G+PKA
Sbjct: 318 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 377
Query: 128 AAEFLNDRVPNCN 140
AA+ L P N
Sbjct: 378 AADRLQKIFPGVN 390
>gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens]
Length = 676
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 71 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI---GRPKAEV 127
K L++GAG LGC + + L G R I +D I SN RQ L+ +D G+PKA
Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416
Query: 128 AAEFLNDRVPNCN 140
AA+ L P N
Sbjct: 417 AADRLQKIFPGVN 429
>gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens]
Length = 703
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 71 KVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI---GRPKAEV 127
K L++GAG LGC + + L G R I +D I SN RQ L+ +D G+PKA
Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416
Query: 128 AAEFLNDRVPNCN 140
AA+ L P N
Sbjct: 417 AADRLQKIFPGVN 429
>gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Homo
sapiens]
Length = 1250
Score = 32.0 bits (71), Expect = 1.2
Identities = 26/122 (21%), Positives = 52/122 (42%), Gaps = 18/122 (14%)
Query: 342 YLVFNDVDGLYTYTFEAERKEN---------CPACSQLPQNIQFSPSA-----KLQEVLD 387
+ +FN + GL+ + F KEN C +L N +S +A K + L
Sbjct: 1099 FSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLG 1158
Query: 388 YLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVA 447
+S+S+ S +T+ + + T + ++ ++ K+L +L DG + ++
Sbjct: 1159 KSLSSSSIGSNSTYLTSKSKSSSTTYFKRN----SHTDSASMDKSLSKLAHADGDQTSII 1214
Query: 448 DV 449
V
Sbjct: 1215 PV 1216
>gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Homo
sapiens]
Length = 1222
Score = 32.0 bits (71), Expect = 1.2
Identities = 26/122 (21%), Positives = 52/122 (42%), Gaps = 18/122 (14%)
Query: 342 YLVFNDVDGLYTYTFEAERKEN---------CPACSQLPQNIQFSPSA-----KLQEVLD 387
+ +FN + GL+ + F KEN C +L N +S +A K + L
Sbjct: 1071 FSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLG 1130
Query: 388 YLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVA 447
+S+S+ S +T+ + + T + ++ ++ K+L +L DG + ++
Sbjct: 1131 KSLSSSSIGSNSTYLTSKSKSSSTTYFKRN----SHTDSASMDKSLSKLAHADGDQTSII 1186
Query: 448 DV 449
V
Sbjct: 1187 PV 1188
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 31.6 bits (70), Expect = 1.6
Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 367 CSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPA--ITATLEGKNRTLYLQSVTSIEER 424
C +Q+ S +L +V+DY+ AS+ PA +E +N+ L +S E
Sbjct: 116 CYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQERE 175
Query: 425 TRPNLSK 431
+ N++K
Sbjct: 176 KKENMAK 182
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 31.6 bits (70), Expect = 1.6
Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 367 CSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPA--ITATLEGKNRTLYLQSVTSIEER 424
C +Q+ S +L +V+DY+ AS+ PA +E +N+ L +S E
Sbjct: 116 CYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQERE 175
Query: 425 TRPNLSK 431
+ N++K
Sbjct: 176 KKENMAK 182
>gi|70887790 DNA-directed DNA polymerase gamma 2 [Homo sapiens]
Length = 485
Score = 31.2 bits (69), Expect = 2.1
Identities = 31/116 (26%), Positives = 41/116 (35%), Gaps = 31/116 (26%)
Query: 16 ELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVI 75
ELL E+ + GG HVK E G HP+ S E + LL+ C+
Sbjct: 31 ELLTERSSPKGG------------HVKSHAELEGNGEHPEAPGSGEGSEALLEICQRRHF 78
Query: 76 -------------------GAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQ 112
G G LG EL KNLA + + V V L+ +
Sbjct: 79 LSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHK 134
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 30.8 bits (68), Expect = 2.7
Identities = 21/65 (32%), Positives = 28/65 (43%), Gaps = 3/65 (4%)
Query: 17 LLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIG 76
+L ++ V GGCG TG + H LE+ G F P P + L +
Sbjct: 286 ILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGG---RLYV 342
Query: 77 AGGLG 81
AGGLG
Sbjct: 343 AGGLG 347
>gi|153792780 additional sex combs like 2 [Homo sapiens]
Length = 1435
Score = 30.4 bits (67), Expect = 3.5
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 7/95 (7%)
Query: 360 RKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVT 419
RKE C + ++ N S L L+ S+ L +K P LE K VT
Sbjct: 443 RKEECESQGEVQPNFSTSSEPLLSSALNTHELSSILPIKCPKDEDLLEQK-------PVT 495
Query: 420 SIEERTRPNLSKTLKELGLVDGQELAVADVTTPQT 454
S E+ + N T + QE V + P++
Sbjct: 496 SAEQESEKNHLTTASNYNKSESQESLVTSPSKPKS 530
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 30.0 bits (66), Expect = 4.6
Identities = 17/66 (25%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 367 CSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSP-AITATLEGKNRTLYLQSVTSIEERT 425
C +Q+ S +L +V+DY+ AS+ P +E +N+ L +S E
Sbjct: 116 CYVCDNEVQYCSSNQLGQVVDYVRKQASITTPKPEKDNGNIELENKKLEKESKNEQEREK 175
Query: 426 RPNLSK 431
+ N++K
Sbjct: 176 KENMAK 181
>gi|5454132 tumor necrosis factor, alpha-induced protein 3 [Homo
sapiens]
Length = 790
Score = 29.6 bits (65), Expect = 6.0
Identities = 14/65 (21%), Positives = 28/65 (43%)
Query: 9 KKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLD 68
K R ++E L +++ G C DT +W W+++ K P + ++ +
Sbjct: 139 KFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTPMARSGLQYNSLEEIHIFV 198
Query: 69 TCKVL 73
C +L
Sbjct: 199 LCNIL 203
>gi|11225260 DNA topoisomerase I [Homo sapiens]
Length = 765
Score = 29.3 bits (64), Expect = 7.9
Identities = 12/26 (46%), Positives = 16/26 (61%)
Query: 43 KFLERSGPFTHPDFEPSTESLQFLLD 68
KFLE GP P +EP E+++F D
Sbjct: 218 KFLEHKGPVFAPPYEPLPENVKFYYD 243
>gi|197927446 sarcosine dehydrogenase precursor [Homo sapiens]
Length = 918
Score = 29.3 bits (64), Expect = 7.9
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 66 LLDTCKVLVIGAGGLGCELLKNLALSG 92
L T V+VIG G LGC+ L +LA G
Sbjct: 63 LPSTANVVVIGGGSLGCQTLYHLAKLG 89
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,177,414
Number of Sequences: 37866
Number of extensions: 829306
Number of successful extensions: 2009
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1953
Number of HSP's gapped (non-prelim): 45
length of query: 463
length of database: 18,247,518
effective HSP length: 106
effective length of query: 357
effective length of database: 14,233,722
effective search space: 5081438754
effective search space used: 5081438754
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.