Search of human proteins with 37622907

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37622907 voltage-gated sodium channel type V alpha isoform a
[Homo sapiens]
         (2016 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  4048   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  4041   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  4034   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  3986   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  3947   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  3883   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  2429   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  2418   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  2418   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  2416   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  2390   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  2382   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  2379   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  2375   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  2353   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2335   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1731   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1375   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1323   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1121   0.0  
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   455   e-127
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...   455   e-127
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...   454   e-127
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   450   e-126
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i...   449   e-125
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i...   449   e-125
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i...   449   e-125
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   449   e-125
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   449   e-125
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   449   e-125

>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 4048 bits (10497), Expect = 0.0
 Identities = 2016/2016 (100%), Positives = 2016/2016 (100%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080

Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
            PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140

Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200

Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260

Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320

Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380

Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440

Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500

Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560

Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620

Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680

Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740

Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800

Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860

Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920

Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980

Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 4041 bits (10480), Expect = 0.0
 Identities = 2015/2016 (99%), Positives = 2015/2016 (99%), Gaps = 1/2016 (0%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK QESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK-QESQ 1079

Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
            PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1080 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1139

Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1140 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1199

Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1200 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1259

Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1260 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1319

Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1320 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1379

Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1380 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1439

Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1440 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1499

Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1500 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1559

Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1560 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1619

Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1620 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679

Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1680 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1739

Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1740 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1799

Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1800 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1859

Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1860 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1919

Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1920 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1979

Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1980 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2015


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 4034 bits (10463), Expect = 0.0
 Identities = 2009/2016 (99%), Positives = 2012/2016 (99%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080

Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
            PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140

Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200

Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260

Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320

Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380

Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440

Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500

Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560

Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620

Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680

Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740

Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800

Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860

Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920

Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980

Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 3986 bits (10337), Expect = 0.0
 Identities = 1991/2016 (98%), Positives = 1994/2016 (98%), Gaps = 18/2016 (0%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080

Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
            PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140

Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200

Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260

Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320

Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380

Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV                  YEEQPQW
Sbjct: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV------------------YEEQPQW 1422

Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1423 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1482

Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1483 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1542

Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1543 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1602

Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1603 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1662

Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1663 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1722

Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1723 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1782

Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1783 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1842

Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1843 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1902

Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1903 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1962

Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1963 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1998


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 3947 bits (10235), Expect = 0.0
 Identities = 1976/2016 (98%), Positives = 1979/2016 (98%), Gaps = 33/2016 (1%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK QESQ
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK-QESQ 1079

Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
            PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
Sbjct: 1080 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1139

Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1140 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1199

Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1200 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1259

Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1260 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1319

Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1320 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1379

Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1380 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1439

Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1440 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1499

Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1500 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1559

Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
            AKINLLFVAIFT                                GTVLSDIIQKYFFSPT
Sbjct: 1560 AKINLLFVAIFT--------------------------------GTVLSDIIQKYFFSPT 1587

Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1588 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1647

Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1648 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1707

Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1708 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1767

Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1768 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1827

Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1828 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1887

Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1888 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1947

Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1948 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1983


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 3883 bits (10071), Expect = 0.0
 Identities = 1952/2016 (96%), Positives = 1955/2016 (96%), Gaps = 54/2016 (2%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ 660

Query: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720
            RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
Sbjct: 661  RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD 720

Query: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780
            LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
Sbjct: 721  LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG 780

Query: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
Sbjct: 781  WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900
            NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
Sbjct: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI 900

Query: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960
            ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
Sbjct: 901  ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ 960

Query: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020
            LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
Sbjct: 961  LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP 1020

Query: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ 1080
            PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ    
Sbjct: 1021 PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQ---- 1076

Query: 1081 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS 1140
                    P DS                                   C E        GS
Sbjct: 1077 -------TPEDS-----------------------------------CSE--------GS 1086

Query: 1141 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1200
            TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
Sbjct: 1087 TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH 1146

Query: 1201 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1260
            IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
Sbjct: 1147 IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 1206

Query: 1261 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1320
            YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1207 YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 1266

Query: 1321 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1380
            RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
Sbjct: 1267 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 1326

Query: 1381 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1440
            KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
Sbjct: 1327 KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1386

Query: 1441 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
            EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
Sbjct: 1387 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1446

Query: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
            LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
Sbjct: 1447 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1506

Query: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
            AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
Sbjct: 1507 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1566

Query: 1621 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
            LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
Sbjct: 1567 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626

Query: 1681 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1740
            YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
Sbjct: 1627 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1686

Query: 1741 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1800
            DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
Sbjct: 1687 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK 1746

Query: 1801 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1860
            FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
Sbjct: 1747 FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR 1806

Query: 1861 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1920
            VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
Sbjct: 1807 VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS 1866

Query: 1921 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1980
            LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
Sbjct: 1867 LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV 1926

Query: 1981 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 2016
            TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Sbjct: 1927 TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV 1962


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 2429 bits (6296), Expect = 0.0
 Identities = 1294/2065 (62%), Positives = 1524/2065 (73%), Gaps = 168/2065 (8%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549  STAGESESHHTSLLVPWPL--RRTSAQGQPSPGTS-APGHALHGKKNSTVDCNGVVSLLG 605
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658

Query: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665
             G    TSP   L        PP+ TT   E    + L+S    ++  E+   RQRA+S 
Sbjct: 659  -GPSALTSPTGQL--------PPEGTTTETEVR-KRRLSSYQISMEMLEDSSGRQRAVSI 708

Query: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768

Query: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828

Query: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888

Query: 846  LAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948

Query: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008

Query: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKEL 1061

Query: 1024 KETRFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEEN 1065
               R   G   G GT    E                   V VPIAV ESD ++   +E +
Sbjct: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1121

Query: 1066 SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQA 1125
            S    EES ++                     ++AT+SSE                    
Sbjct: 1122 SESELEESKEK---------------------LNATSSSE-------------------- 1140

Query: 1126 PGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQ 1185
                         GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +
Sbjct: 1141 -------------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEE 1186

Query: 1186 APGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKM 1245
              GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+
Sbjct: 1187 GKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKV 1246

Query: 1246 FTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTL 1305
            FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTL
Sbjct: 1247 FTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTL 1306

Query: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
            RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N
Sbjct: 1307 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN 1366

Query: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
             T G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIM
Sbjct: 1367 MTTGNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIM 1423

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            YAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDI
Sbjct: 1424 YAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDI 1483

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545
            FMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTM
Sbjct: 1484 FMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1543

Query: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605
            MVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG
Sbjct: 1544 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVG 1603

Query: 1606 TVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLF 1665
              L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLF
Sbjct: 1604 MFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF 1663

Query: 1666 LVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGP 1725
            LVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ P
Sbjct: 1664 LVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723

Query: 1726 PYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1784
            P CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES E
Sbjct: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAE 1783

Query: 1785 PLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVS 1844
            PLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVS
Sbjct: 1784 PLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVS 1843

Query: 1845 GDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1904
            GDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVS
Sbjct: 1844 GDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVS 1903

Query: 1905 AMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPS 1964
            A +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  
Sbjct: 1904 AAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEK 1957

Query: 1965 SSSISSTSFPPSYDSVTRATSDNLQ 1989
            +   SST+ PPSYDSVT+   +  +
Sbjct: 1958 TDGSSSTTSPPSYDSVTKPDKEKFE 1982


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 2418 bits (6267), Expect = 0.0
 Identities = 1294/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708

Query: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828

Query: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888

Query: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948

Query: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008

Query: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059

Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119

Query: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
            +E +S    EES ++                     ++AT+SSE                
Sbjct: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146

Query: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
            +  AP  GE PE    E                        +PE CFTE CVR+  CC +
Sbjct: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184

Query: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
               +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244

Query: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
            ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304

Query: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364

Query: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
             CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423

Query: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
            WMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483

Query: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543

Query: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
            NMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVI
Sbjct: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603

Query: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663

Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723

Query: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
            LN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783

Query: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
            EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MD
Sbjct: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843

Query: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903

Query: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
             EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +  
Sbjct: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959

Query: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
              P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 2418 bits (6267), Expect = 0.0
 Identities = 1294/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708

Query: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828

Query: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888

Query: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948

Query: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008

Query: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059

Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119

Query: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
            +E +S    EES ++                     ++AT+SSE                
Sbjct: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146

Query: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
            +  AP  GE PE    E                        +PE CFTE CVR+  CC +
Sbjct: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184

Query: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
               +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244

Query: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
            ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304

Query: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364

Query: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
             CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423

Query: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
            WMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483

Query: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543

Query: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
            NMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVI
Sbjct: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603

Query: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663

Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723

Query: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
            LN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783

Query: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
            EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MD
Sbjct: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843

Query: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903

Query: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
             EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +  
Sbjct: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959

Query: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
              P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 2416 bits (6262), Expect = 0.0
 Identities = 1293/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 183  DFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708

Query: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828

Query: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888

Query: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948

Query: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008

Query: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059

Query: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119

Query: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121
            +E +S    EES ++                     ++AT+SSE                
Sbjct: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146

Query: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181
            +  AP  GE PE    E                        +PE CFTE CVR+  CC +
Sbjct: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184

Query: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241
               +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244

Query: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301
            ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304

Query: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364

Query: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420
             CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423

Query: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480
            WMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483

Query: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543

Query: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600
            NMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVI
Sbjct: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603

Query: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663

Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723

Query: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
            LN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783

Query: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839
            EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MD
Sbjct: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843

Query: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903

Query: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959
             EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +  
Sbjct: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959

Query: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000
              P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 2390 bits (6195), Expect = 0.0
 Identities = 1280/2068 (61%), Positives = 1507/2068 (72%), Gaps = 159/2068 (7%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 6    LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301

Query: 289  GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
            GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 302  GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358

Query: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418

Query: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478

Query: 459  ---SSLEMSPLAPVNSHERRSKRRKRMS---SGTEECGEDRLPKSDSEDGPRAMN----- 507
               SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 479  LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538

Query: 508  --------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENSTA 551
                          H SL           R+SR S+F+FR R  D+GSE DFADDE+ST 
Sbjct: 539  EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598

Query: 552  GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608
             ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 599  EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
               TSP   LL       P  TTT +E     +  +S    +D  E+P  RQRA+S  S+
Sbjct: 658  SVPTSPVGQLL-------PEGTTTETEMR--KRRSSSFHVSMDFLEDPSQRQRAMSIASI 708

Query: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
            LT+ +EELEESR KCPPCW + +  +LIW+C P W+ +K  V LVVMDPF DL IT+CIV
Sbjct: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768

Query: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
            LNTLFMA+EHY MT  F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD  I
Sbjct: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828

Query: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
            V LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888

Query: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
            IVFIFAVVGMQLFGK+Y +   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948

Query: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
            MEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+
Sbjct: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008

Query: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
             +G+ +VKR  ++F   + +   +K   L     L        S     T ++       
Sbjct: 1009 HKGVAYVKRKIYEF---IQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYL 1065

Query: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068
            +   G   G GT    E                   V VPIAV ESD ++        L 
Sbjct: 1066 KDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFEN--------LN 1117

Query: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128
            TE+ SS+                            S+ E S  + +              
Sbjct: 1118 TEDFSSE----------------------------SDLEESKEKLN-------------- 1135

Query: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188
                  S SEGST D+    E  EQ     ++  +PE CFTEGCV+R  CC ++  +  G
Sbjct: 1136 ---ESSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRG 1190

Query: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248
            K WW LR+TC+ IVEH+WFETFI+FMILLSSGALAFEDIY+++RKTIK +LEYADK+FTY
Sbjct: 1191 KQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTY 1250

Query: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308
            +F+LEMLLKWVAYG++ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRAL
Sbjct: 1251 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1310

Query: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368
            RPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T 
Sbjct: 1311 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTT 1370

Query: 1369 GDLPLNYTIVNNKSQCESLNLTGE-LYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427
            GD   +   VNN + C  L    E   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYA
Sbjct: 1371 GD-RFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA 1429

Query: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1487
            AVDSR  E QP++E +LYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFM
Sbjct: 1430 AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1489

Query: 1488 TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMV 1547
            TEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMV
Sbjct: 1490 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV 1549

Query: 1548 ETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTV 1607
            ETDDQS     IL++INL+F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVILSIVG  
Sbjct: 1550 ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMF 1609

Query: 1608 LSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLV 1667
            L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLV
Sbjct: 1610 LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1669

Query: 1668 MFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPY 1727
            MFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP 
Sbjct: 1670 MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPD 1729

Query: 1728 CDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPL 1786
            CDP   N   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPL
Sbjct: 1730 CDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPL 1789

Query: 1787 SEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGD 1846
            SEDDF+MFYE+WEKFDP+ATQF+E+  LS FA AL  PL + +PN++ LI MDLPMVSGD
Sbjct: 1790 SEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGD 1849

Query: 1847 RIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAM 1906
            RIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SY+PITTTL+RK EEVSA+
Sbjct: 1850 RIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV 1909

Query: 1907 VIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSS 1966
            +IQRA+RRHLL+R++K ASF + +    G    +   +E +I   ++EN    +   +  
Sbjct: 1910 IIQRAYRRHLLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRINEN---SITEKTDL 1964

Query: 1967 SISSTSFPPSYDSVTRATSDNLQVRGSD 1994
            ++S+ + PPSYD VT+   +  +  G D
Sbjct: 1965 TMSTAACPPSYDRVTKPIVEKHEQEGKD 1992


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 2382 bits (6172), Expect = 0.0
 Identities = 1271/2062 (61%), Positives = 1501/2062 (72%), Gaps = 211/2062 (10%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662

Query: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722

Query: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782

Query: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842

Query: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902

Query: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962

Query: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015

Query: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075

Query: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128
              EES ++                     ++AT+SSE                       
Sbjct: 1076 ELEESKEK---------------------LNATSSSE----------------------- 1091

Query: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188
                      GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +  G
Sbjct: 1092 ----------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKG 1140

Query: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248
            K+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY
Sbjct: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200

Query: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308
            +F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRAL
Sbjct: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260

Query: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368
            RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T 
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320

Query: 1369 GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1428
            G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAA
Sbjct: 1321 GNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1377

Query: 1429 VDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1488
            VDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMT
Sbjct: 1378 VDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMT 1437

Query: 1489 EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
            EEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVE
Sbjct: 1438 EEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVE 1497

Query: 1549 TDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVL 1608
            TDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L
Sbjct: 1498 TDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFL 1557

Query: 1609 SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
            +++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVM
Sbjct: 1558 AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1617

Query: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
            FIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP C
Sbjct: 1618 FIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1677

Query: 1729 DP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
            DP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLS
Sbjct: 1678 DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1737

Query: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
            EDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDR
Sbjct: 1738 EDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDR 1797

Query: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
            IHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +
Sbjct: 1798 IHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAI 1857

Query: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
            IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +  
Sbjct: 1858 IQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDG 1911

Query: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
             SST+ PPSYDSVT+   +  +
Sbjct: 1912 SSSTTSPPSYDSVTKPDKEKFE 1933


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 2379 bits (6166), Expect = 0.0
 Identities = 1270/2062 (61%), Positives = 1500/2062 (72%), Gaps = 211/2062 (10%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDFSVI+MAY TEFV LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662

Query: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722

Query: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782

Query: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842

Query: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902

Query: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962

Query: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015

Query: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075

Query: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128
              EES ++                     ++AT+SSE                       
Sbjct: 1076 ELEESKEK---------------------LNATSSSE----------------------- 1091

Query: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188
                      GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +  G
Sbjct: 1092 ----------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKG 1140

Query: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248
            K+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY
Sbjct: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200

Query: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308
            +F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRAL
Sbjct: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260

Query: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368
            RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T 
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320

Query: 1369 GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1428
            G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAA
Sbjct: 1321 GNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1377

Query: 1429 VDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1488
            VDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMT
Sbjct: 1378 VDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMT 1437

Query: 1489 EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
            EEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVE
Sbjct: 1438 EEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVE 1497

Query: 1549 TDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVL 1608
            TDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L
Sbjct: 1498 TDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFL 1557

Query: 1609 SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
            +++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVM
Sbjct: 1558 AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1617

Query: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
            FIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP C
Sbjct: 1618 FIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1677

Query: 1729 DP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
            DP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLS
Sbjct: 1678 DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1737

Query: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
            EDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDR
Sbjct: 1738 EDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDR 1797

Query: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
            IHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +
Sbjct: 1798 IHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAI 1857

Query: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
            IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +  
Sbjct: 1858 IQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDG 1911

Query: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
             SST+ PPSYDSVT+   +  +
Sbjct: 1912 SSSTTSPPSYDSVTKPDKEKFE 1933


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 2375 bits (6156), Expect = 0.0
 Identities = 1260/2021 (62%), Positives = 1485/2021 (73%), Gaps = 112/2021 (5%)

Query: 10   TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69
            T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10   TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68

Query: 70   NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129
              P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 69   ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128

Query: 130  HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189
            HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 129  HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185

Query: 190  RDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKK 249
            RDPWNWLDFSVI +AY    +DL  +S LRTFRVLRALKT+SVI GLK IVGALI SVKK
Sbjct: 186  RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245

Query: 250  LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309
            LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 246  LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291

Query: 310  D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367
               P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 292  HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351

Query: 368  LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427
            LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 352  LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411

Query: 428  EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487
            E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 412  EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471

Query: 488  ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545
            E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+       D
Sbjct: 472  E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDISLPEGVTD 522

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLG 605
            D     G+ ESH  SLL+          GQ  P   +P                   L  
Sbjct: 523  D-GVFPGDHESHRGSLLLG------GGAGQQGPLPRSP-------------------LPQ 556

Query: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665
              +P++         P   E  P     S    G +     A  +D   EP   QRA+S 
Sbjct: 557  PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSV 613

Query: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725
            VS++TS LEELEES  KCPPC   L+Q+YLIW+CCP+W+ +K  +  +V DPF +LTIT+
Sbjct: 614  VSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITL 673

Query: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785
            CIV+NT+FMA+EH+ M+  FE MLQ+GN+VFT  FTAEM FKIIA DPYYYFQ+ WNIFD
Sbjct: 674  CIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFD 733

Query: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
             IIV +SL+ELG+++  +LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLT++
Sbjct: 734  CIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTII 793

Query: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDSGL---LPRWHMMDFFHAFLIIFRILCGEWIET 902
            LAIIVF+FA+VG QL G+NY   R + S      PRWHM DFFH+FLI+FRILCGEWIE 
Sbjct: 794  LAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIEN 853

Query: 903  MWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLA 962
            MW CMEV  +S+CL++FL VMV+GNLVVLNLF+ALLL+SFSADNLTAP++D E+NNLQ+A
Sbjct: 854  MWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVA 913

Query: 963  LARIQRGLRFVKRTTWDFCCGLLRQRP-QKPAALAAQGQLPSCIATPYSPPPPETEKVPP 1021
            LARIQ    F  RT    C    R  P  +P A     +    +  P S    E      
Sbjct: 914  LARIQV---FGHRTKQALCSFFSRSCPFPQPKA-----EPELVVKLPLSSSKAENHIAAN 965

Query: 1022 TRKETRFEEGEQPGQGTPGDPEP------------VCVPIAVAESDTDDQEEDEENSLGT 1069
            T +      G   G   P  P              V VPIA  ESD DD E+D     G 
Sbjct: 966  TAR------GSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDD-----GG 1014

Query: 1070 EEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQA-DWRQQWKAE--PQAP 1126
            E+  S QQE  P     +     R    ++  +     +S   A    + WK E  PQ P
Sbjct: 1015 EDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVP 1074

Query: 1127 GCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1186
              G   + S SEGST D  +  E+L +IP+L  D+++P+DCFTEGC+R CPCC +DTT++
Sbjct: 1075 AEG-VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKS 1133

Query: 1187 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1246
            P  V W++RKTCY IVEHSWFE+FIIFMILLSSG+LAFED YL+++ T+K LLEY D++F
Sbjct: 1134 PWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVF 1193

Query: 1247 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1306
            T++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++SL+SL A  L ++E+ PIK+LRTLR
Sbjct: 1194 TFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLR 1253

Query: 1307 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1366
            ALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF RCIN 
Sbjct: 1254 ALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINY 1313

Query: 1367 TEGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            T+G+  L   +IVNNKS C+  N TG  +W  VKVNFDNV  GYLALLQVATFKGWMDIM
Sbjct: 1314 TDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIM 1373

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            YAAVDSR    QP+WE N+YMY+YFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGGQDI
Sbjct: 1374 YAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDI 1433

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545
            FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+FDIVT+QAFD+TIM LICLNM+TM
Sbjct: 1434 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITM 1493

Query: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605
            MVETDDQS EK  IL KIN  FVA+FTGEC++K+ ALR YYFTN WN+FDF+VV+LSI  
Sbjct: 1494 MVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIAS 1553

Query: 1606 TVLSDIIQKY--FFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1663
             + S I++    +FSPTLFRVIRLARIGRILRLIR AKGIRTLLFALMMSLPALFNIGLL
Sbjct: 1554 LIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLL 1613

Query: 1664 LFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1723
            LFLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT
Sbjct: 1614 LFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1673

Query: 1724 GPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST 1783
            GPPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIISFLI+VNMYIA+ILENF+VATEEST
Sbjct: 1674 GPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEEST 1733

Query: 1784 EPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMV 1843
            EPLSEDDFDMFYE WEKFDPEATQFI +S LSDFAD LS PLRI KPN+  LI MDLP+V
Sbjct: 1734 EPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLV 1793

Query: 1844 SGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEV 1903
             GD+IHC+DILFAFTK VLGESGE+D+LK  MEEKFMA N SK SYEPI TTLR K E++
Sbjct: 1794 PGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDI 1853

Query: 1904 SAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPE--REGLIAYVMSENFSRPLG 1961
            SA VIQ+A+R ++L RS+  ++     +A     EE+A     EG +A+  +EN    + 
Sbjct: 1854 SATVIQKAYRSYVLHRSMALSNTPCVPRA-----EEEAASLPDEGFVAFTANENC---VL 1905

Query: 1962 PPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLA 2002
            P  S + S+TSFPPSY+SVTR  SD + +R S    +ED A
Sbjct: 1906 PDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEA 1946


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 2353 bits (6097), Expect = 0.0
 Identities = 1249/2052 (60%), Positives = 1514/2052 (73%), Gaps = 144/2052 (7%)

Query: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
            L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 4    LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59

Query: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
            P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 60   PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119

Query: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
            +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 120  IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179

Query: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
             FTFLRDPWNWLDF VI+ AY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 180  EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239

Query: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S+        +L
Sbjct: 240  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI------MNTL 293

Query: 305  DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364
            +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 294  ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353

Query: 365  LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424
            LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 354  LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413

Query: 425  AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471
             E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 414  EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473

Query: 472  HERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPRAMN-HLSLT-------RGLSRTS 519
             ERR++R+K+    +SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 474  KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533

Query: 520  MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566
              P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 534  QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593

Query: 567  LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEH 626
             +   +        S P   ++GK +S VDCNGVVSL+  G      P   LL       
Sbjct: 594  PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD-GRSALMLPNGQLL------- 645

Query: 627  PPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPC 686
            P  TT    +    +  +S     D   +P  RQRA+S  S+LT+ +EELEESR KCPP 
Sbjct: 646  PEGTTNQIHKK---RRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPW 702

Query: 687  WNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFE 746
            W R A ++LIW C P W+  K+ +  +VMDPF DL IT+CIVLNTLFMA+EH+ MT EF+
Sbjct: 703  WYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFK 762

Query: 747  EMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSV 806
             +L +GNLVFTGIF AEM  K+IA+DPY YFQ GWNIFDS+IV LSL+EL L+ +  LSV
Sbjct: 763  NVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSV 822

Query: 807  LRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866
            LRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y 
Sbjct: 823  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 882

Query: 867  EL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMV 924
            E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDCMEV+GQ++CL+V+++VMV
Sbjct: 883  ECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMV 942

Query: 925  IGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL 984
            IGNLVVLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F    
Sbjct: 943  IGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKA 1002

Query: 985  LRQRPQKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------E 1032
              ++P+    +     L +      S     E  K     KE     G           +
Sbjct: 1003 FSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMED 1062

Query: 1033 QPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPD 1091
              GQ    +P   V VPIA  ESD ++   +E +S    E                    
Sbjct: 1063 SDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSE-------------------- 1102

Query: 1092 SRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELL 1151
               +S+V    SS +E S            +   PG GE  E        A+  N+ E  
Sbjct: 1103 ---YSKVRLNRSSSSECST----------VDNPLPGEGEEAE--------AEPMNSDE-- 1139

Query: 1152 EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFI 1211
                        PE CFT+GCVRR  CC V+     GK+WW +RKTCY IVEHSWFE+FI
Sbjct: 1140 ------------PEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFI 1187

Query: 1212 IFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAW 1271
            + MILLSSGALAFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K YFTNAW
Sbjct: 1188 VLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAW 1247

Query: 1272 CWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1331
            CWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAI
Sbjct: 1248 CWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAI 1307

Query: 1332 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCESL-NL 1389
            PSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C +L N+
Sbjct: 1308 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECFALMNV 1365

Query: 1390 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1449
            +  + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++EY+LYMYIY
Sbjct: 1366 SQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIY 1425

Query: 1450 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1509
            FV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP
Sbjct: 1426 FVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1485

Query: 1510 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVA 1569
            IPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN++F+ 
Sbjct: 1486 IPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFII 1545

Query: 1570 IFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLAR 1629
            +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTLFRVIRLAR
Sbjct: 1546 LFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLAR 1605

Query: 1630 IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGID 1689
            IGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E GI+
Sbjct: 1606 IGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGIN 1665

Query: 1690 DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVG 1748
            DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG+P+VG
Sbjct: 1666 DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVG 1725

Query: 1749 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1808
            I +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP+ATQF
Sbjct: 1726 IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQF 1785

Query: 1809 IEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEM 1868
            IE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEM
Sbjct: 1786 IEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEM 1845

Query: 1869 DALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLF 1928
            D+L+ QMEE+FM+ANPSK+SYEPITTTL+RK E+VSA VIQRA+RR+ L++++K+ S ++
Sbjct: 1846 DSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY 1905

Query: 1929 RQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNL 1988
             +    G  ++D   ++ +    ++EN S    P  + + SST+ PPSYDSVT+   +  
Sbjct: 1906 IK---DGDRDDDLLNKKDMAFDNVNENSS----PEKTDATSSTTSPPSYDSVTKPDKEKY 1958

Query: 1989 QVRGSDYSHSED 2000
            +    D +  ED
Sbjct: 1959 E---QDRTEKED 1967


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2335 bits (6051), Expect = 0.0
 Identities = 1277/2062 (61%), Positives = 1498/2062 (72%), Gaps = 179/2062 (8%)

Query: 2    ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
            A  L P G  SF+ FT ESLA IE+R+AE + +       S     E+  P+P  DL+A 
Sbjct: 3    ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62

Query: 62   KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
            K LP +YG+ PQ L+  PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 63   KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122

Query: 122  RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
            R A+KIL+HS+F+M+IMCTILTNCVFM   +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 123  RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182

Query: 182  CLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVG 241
            C+  FTFLRDPWNWLDFSVI+MAY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVG
Sbjct: 183  CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242

Query: 242  ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
            ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV    NF      NG+    G
Sbjct: 243  ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299

Query: 299  LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
              WE    Y+++  N+    G  + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 300  FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356

Query: 359  AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
            +WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 357  SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416

Query: 419  QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
            QNQAT+ E E+KE  F+  +E LKK+ E    A       TVS               RS
Sbjct: 417  QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476

Query: 460  SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
            S E+S L+  ++ ERR++R+KR    +S G E+   +++ KS+SEDG R           
Sbjct: 477  SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536

Query: 505  ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
                ++ + SL        +   +S+ SIF+FR     RD GSE +FADDE+ST  ESE 
Sbjct: 537  GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596

Query: 557  HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
               SL +P   R  R+S  G    S G+ +    P      K+NSTVDCNGVVSL+G   
Sbjct: 597  RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654

Query: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
                 PGSH+   ++ E   +     + PG   +L S    +D     G + R  S +SV
Sbjct: 655  -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703

Query: 669  LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
            +T+ L EELEES+ KCPPCW + A  +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 704  VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763

Query: 728  VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
            VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM  K+IA+DPYYYFQ+GWNIFD  
Sbjct: 764  VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823

Query: 788  IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            IV LSLMEL L+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 824  IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883

Query: 848  IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
            IIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 884  IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943

Query: 906  CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
            CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 944  CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003

Query: 966  IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
            I++G+ + K     F     +QR     KP     + +  +CIA                
Sbjct: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062

Query: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
               T    G        ++       +P   V VPIAV ESD ++        L TE+ S
Sbjct: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFEN--------LNTEDVS 1114

Query: 1074 SKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPE 1133
            S+                            S+ E S  + D                  +
Sbjct: 1115 SE----------------------------SDPEGSKDKLD------------------D 1128

Query: 1134 DSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW 1192
             S SEGST D+      +E++P +  ++  DP+ CFTEGCV+R  CC V+  +  GK WW
Sbjct: 1129 TSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWW 1185

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
             LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+FTY+F+L
Sbjct: 1186 ILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFIL 1245

Query: 1253 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLR 1312
            EMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLR
Sbjct: 1246 EMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLR 1305

Query: 1313 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLP 1372
            ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+  C N+T  ++ 
Sbjct: 1306 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS-EIR 1364

Query: 1373 LNYTIVNNKSQCESL---NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1429
                 VNNK++CE L   N T E+ W  VK+NFDNVGAGYLALLQVATFKGWMDIMYAAV
Sbjct: 1365 FEIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAV 1423

Query: 1430 DSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489
            DSR  +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTE
Sbjct: 1424 DSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1483

Query: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET 1549
            EQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVET
Sbjct: 1484 EQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVET 1543

Query: 1550 DDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLS 1609
            D QS +  NIL  INL+FV  FT EC++K+ ALRHYYFT  WNIFDFVVVILSIVG  L+
Sbjct: 1544 DTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLA 1603

Query: 1610 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1669
            DII+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1604 DIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1663

Query: 1670 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC- 1728
            I+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN  PP C 
Sbjct: 1664 IFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCS 1722

Query: 1729 -DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
             D   P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEES +PLS
Sbjct: 1723 LDKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS 1781

Query: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
            EDDF+ FYEIWEKFDP+ATQFIEY  L+DFADAL  PLR+ KPN I LI MDLPMVSGDR
Sbjct: 1782 EDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDR 1841

Query: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
            IHC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK EEVSA+V
Sbjct: 1842 IHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVV 1901

Query: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
            +QRA+R HL +R      F+ ++   + L E     RE                     S
Sbjct: 1902 LQRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE------------------KKES 1937

Query: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
              ST+  PSYDSVT+   +  Q
Sbjct: 1938 TPSTASLPSYDSVTKPEKEKQQ 1959


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1731 bits (4484), Expect = 0.0
 Identities = 894/1335 (66%), Positives = 1036/1335 (77%), Gaps = 81/1335 (6%)

Query: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575

Query: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635

Query: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695

Query: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755

Query: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815

Query: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871

Query: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931

Query: 1055 DTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQAD 1114
            D +   E+E ++    E+S K    QP+  G             +++  S A+    + D
Sbjct: 932  DLEMPTEEETDTFSEPEDSKKPP--QPLYDG-------------NSSVCSTADYKPPEED 976

Query: 1115 WRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVR 1174
              +Q +  P+                                     + PE+CFTE CV+
Sbjct: 977  PEEQAEENPEG------------------------------------EQPEECFTEACVQ 1000

Query: 1175 RCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1234
            R PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAFEDIY+E+R+ 
Sbjct: 1001 RWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRV 1060

Query: 1235 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1294
            I+ +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++SLVAN LG++
Sbjct: 1061 IRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYS 1120

Query: 1295 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1354
            E+GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVN
Sbjct: 1121 ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1180

Query: 1355 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1414
            LFAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DNVG GYL+LLQ
Sbjct: 1181 LFAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239

Query: 1415 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1474
            VATFKGWMDIMYAAVDSR  EEQPQ+E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1299

Query: 1475 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1534
            QQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+VTKQAFD+TI
Sbjct: 1300 QQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITI 1359

Query: 1535 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1594
            M LICLNMVTMMVETD+QS  K++IL  IN++F+ IFTGEC++K+ ALR YYFT  WNIF
Sbjct: 1360 MILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIF 1419

Query: 1595 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654
            DFVVVILSIVG  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSL
Sbjct: 1420 DFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479

Query: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1714
            PALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CLF+ITTSAGWD
Sbjct: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539

Query: 1715 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1773
            GLL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIVVNMYIAIILE
Sbjct: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599

Query: 1774 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1833
            NF+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L EPLRIAKPN+I
Sbjct: 1600 NFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKI 1659

Query: 1834 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1893
             LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAANPSK+SYEPIT
Sbjct: 1660 KLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPIT 1719

Query: 1894 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAPEREGLIAYVM 1952
            TTL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAPE+EGL+A  M
Sbjct: 1720 TTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAPEKEGLLANTM 1776

Query: 1953 SENFSRPLGPPSSSS 1967
            S+ +    G  SS S
Sbjct: 1777 SKMYGHENGNSSSPS 1791



 Score =  602 bits (1551), Expect = e-171
 Identities = 306/478 (64%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFVDLGN+SALRTFRVLRALKTI+VI GLKTIVGALI
Sbjct: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304

Query: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364

Query: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424

Query: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF ++ FT   + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194

Query: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227

Query: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282

Query: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171

Query: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225

Query: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1358
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173

Query: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232

Query: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 46/167 (27%), Positives = 84/167 (50%), Gaps = 22/167 (13%)

Query: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631

Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-----NVSALRTFRVLRALKTISVIS 234
              +  + + +  WN  D S+I+   T   V+LG      +S LR+FR+LR  K      
Sbjct: 632 ---MDPYEYFQQGWNIFD-SIIV---TLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWP 684

Query: 235 GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
            L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 685 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 1401 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1460
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437

Query: 1461 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477



 Score = 38.9 bits (89), Expect = 0.051
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451

Query: 944 ADNLTAPDEDRE 955
             N     ED+E
Sbjct: 452 EQNEATLAEDKE 463


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1375 bits (3559), Expect = 0.0
 Identities = 739/1330 (55%), Positives = 927/1330 (69%), Gaps = 74/1330 (5%)

Query: 616  SHLLRPVMLEHPPDTTTPSEEPGGPQMLT-----SQAPCVDGFEEPG---ARQRALSAVS 667
            S  LR    + PP + +  +    PQ+L      SQ   +D F+E G    RQRALSAVS
Sbjct: 468  SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVS 527

Query: 668  VLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
            +LT  ++E E+S+  C PC   LA +YL+W CCP W+ +K+ ++ V+ DPFT+L IT+CI
Sbjct: 528  ILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICI 587

Query: 728  VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
            ++NT+F+A+EH+ M + FE+ML +GNLVFT IF AEM  KIIALDPY+YF++GWNIFDSI
Sbjct: 588  IINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSI 647

Query: 788  IVILSLMELGLSRMSNLS--VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845
            + +LS  ++    +   S   LRSFR+LRVFKLAKSWPTLNTLIKIIGNSVGALG+LT+V
Sbjct: 648  VALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVV 707

Query: 846  LAIIVFIFAVVGMQLFGKNYSELRDSDS--------GLLPRWHMMDFFHAFLIIFRILCG 897
            L I++FIF+VVGMQLFG++++  +              L  WHM DF+H+FL++FRILCG
Sbjct: 708  LVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCG 767

Query: 898  EWIETMWDCMEVSG--QSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE-DR 954
            EWIE MW+CM+ +    SLC++VF+L+ VIG LVVLNLF+ALLL+SFS +      E + 
Sbjct: 768  EWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEA 827

Query: 955  EMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR---PQKPAALAAQGQLPSCIATPYSP 1011
                +QLAL R +R   FV+ T   FC    R++    QK  A     Q    I     P
Sbjct: 828  RKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDII-----P 882

Query: 1012 PPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
               E ++   T++E           G   D   +  P+A  E D +   ED    +   E
Sbjct: 883  LVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA-PLAEEEDDVEFSGEDNAQRITQPE 941

Query: 1072 ESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGET 1131
               +  E    +      P S+    V     SE E   +  D R++             
Sbjct: 942  PEQQAYELHQEN----KKPTSQRVQSVEIDMFSEDEPHLTIQDPRKK-----------SD 986

Query: 1132 PEDSCSEGSTADMTNTAELL-EQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKV 1190
                 SE ST D+ +    L E +P      K PE C  +G     PCC+VD  + P  +
Sbjct: 987  VTSILSECSTIDLQDGFGWLPEMVPK-----KQPERCLPKGFGCCFPCCSVDKRKPPWVI 1041

Query: 1191 WWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVF 1250
            WW LRKTCY IV+HSWFE+FIIF+ILLSSGAL FED++LE +  I+ LL   D +FT++F
Sbjct: 1042 WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIF 1101

Query: 1251 VLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRP 1310
            +LEM+LKWVA+GF KYFT+AWC LDF+IV VS+ +L+        +  +KS RTLRALRP
Sbjct: 1102 ILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRP 1154

Query: 1311 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD 1370
            LRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV  F+GKFG+CIN T  D
Sbjct: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT--D 1212

Query: 1371 LPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1430
              +NYTI+ NKSQCES    G   W   KVNFDNVG  YLALLQVATFKGWMDI+YAAVD
Sbjct: 1213 SVINYTIITNKSQCES----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVD 1268

Query: 1431 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE 1490
            S   E+QP++E N   YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KKLGGQDIFMTEE
Sbjct: 1269 STEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEE 1328

Query: 1491 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD 1550
            QKKYYNAMKKLGSKKPQKPIPRPLNK QG +FDIVT Q FD+ I+ LI LNM++MM E+ 
Sbjct: 1329 QKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESY 1388

Query: 1551 DQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD 1610
            +Q     +IL  +N +FV IFT EC++K+ ALR YYFTN WN+FD VVV+LSIV T++S 
Sbjct: 1389 NQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMIST 1448

Query: 1611 IIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668
            +  +    F PTLFR++RLARIGRILRL+R A+GIRTLLFALMMSLP+LFNIGLLLFL+M
Sbjct: 1449 LENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIM 1508

Query: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728
            FIY+I GM  F+ V  E+GIDD+FNF+TFA+SMLCLFQI+TSAGWD LLSP+L       
Sbjct: 1509 FIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLR------ 1562

Query: 1729 DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1788
              +  + N S  +C  P +   +F +YIIISFLIVVNMYIA+ILENF+ ATEES +PL E
Sbjct: 1563 --SKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE 1620

Query: 1789 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1848
            DDFD+FYE+WEKFDPEATQFI+YS LSDFADAL EPLR+AKPN+   + MDLPMVS DR+
Sbjct: 1621 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL 1680

Query: 1849 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1908
            HCMDILFAFT RVLG S  +D++K  MEEKFM ANP K  YEPI TT +RK EE  A +I
Sbjct: 1681 HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII 1740

Query: 1909 QRAFRRHLLQ 1918
            Q+AFR+++++
Sbjct: 1741 QKAFRKYMMK 1750



 Score =  453 bits (1165), Expect = e-127
 Identities = 256/516 (49%), Positives = 334/516 (64%), Gaps = 37/516 (7%)

Query: 12  SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
           +FR FT +SLAAIEKR+A ++ +     ++S++   E   PRPQLDL+AS+KLP LYG+ 
Sbjct: 15  NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69

Query: 72  PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
           P+ELIG+PLEDLDPFY   KTF+VLN+ +TI+RFSA +AL++  PF+ IR  A+++ VHS
Sbjct: 70  PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129

Query: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
           LF+M I+ T++ NCVFMA    ++     T   E  FT IY FE+L+KILARGF L  F+
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189

Query: 188 FLRDPWNWLDFSVIIMAYTTEFVDLG-NVSALRTFRVLRALKTISVISGLKTIVGALIQS 246
           FLRDPWNWLD  VI +A  +    +   +  LRTFRV RALK ISV+S LK IVGAL++S
Sbjct: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249

Query: 247 VKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDL 306
           VKKL +V++LT FCLS+FAL+G QLFMG+L  KC+                         
Sbjct: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-------------------- 289

Query: 307 YLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAF 362
            +S+PE Y      K  + +  +CG       C   Y C     NPD+ YT+FD+F W+F
Sbjct: 290 NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSF 349

Query: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQA 422
           LA+FRLMTQD WE+LYQQTLR+ G   + FF++VIFLGSFYL+NL LAVV MAYEEQN+ 
Sbjct: 350 LAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKN 409

Query: 423 TIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRM 482
             AE E KEK FQEA ++LK+E EAL   G+D  S +SLE S   P     +    +KR 
Sbjct: 410 VAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKRK 467

Query: 483 SSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
           S    E G+D+ P SDS ED  +    L  T+ LS+
Sbjct: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/337 (23%), Positives = 153/337 (45%), Gaps = 47/337 (13%)

Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
            +R     +  HS F  FII  ++++   +A             +    A+ +FT +++ E
Sbjct: 118  IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDI----AECVFTGIYIFE 173

Query: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
             L+K +A GF      +  + W WLD +++ +++VS +           +  LRT R  R
Sbjct: 174  ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228

Query: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RCINQTE 1368
             L+A+S    ++V+V AL+ ++  ++NV+++      IF+++G  LF G    +CI++  
Sbjct: 229  ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288

Query: 1369 GDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK-----VNFDNVGAG 1408
             ++  P  Y     K +       C       + ++  E   TK+       NFDN G  
Sbjct: 289  KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348

Query: 1409 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1468
            +LA+ ++ T   W  +    + + G          LY   +F++ I  GSF+ +NL + V
Sbjct: 349  FLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVIFLGSFYLINLTLAV 398

Query: 1469 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1505
            +   + +Q K +  +   +  ++K +  A + L  +K
Sbjct: 399  VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 81/343 (23%), Positives = 150/343 (43%), Gaps = 69/343 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
            +R+   +I+ HS F   I+  IL +    +F   H  + P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTIS 231
             ++K +A GF      +    W  LDF ++I++ TT  ++L  + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVSVTT-LINLMELKSFRTLRALRPLRALS 1159

Query: 232  VISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G    KC+      NGT+
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212

Query: 292  GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
              +                  NY +    S                  +C     +  + 
Sbjct: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236

Query: 352  YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
              +FD+   A+LAL ++ T   W  +           QQ    +  +  I+F++ I  GS
Sbjct: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296

Query: 402  FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
            F+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 155/803 (19%), Positives = 286/803 (35%), Gaps = 173/803 (21%)

Query: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA----LDPYYYFQQGWN 782
            +++N +FMA      ++       +   VFTGI+  E   KI+A    LD + + +  WN
Sbjct: 139  VIINCVFMATGPAKNSNS--NNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196

Query: 783  IFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 842
              DSI++ ++++         L  LR+FR+ R  K       L  ++  +  SV  L N+
Sbjct: 197  WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256

Query: 843  TLVLAIIVFIFAVVGMQLF------------GKNYSELRDSD------------------ 872
             ++    + IFA+VG QLF             KN S     D                  
Sbjct: 257  IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316

Query: 873  --------------SGLLPRWHMMDFFH---AFLIIFRILCGEWIETMWDCMEVSGQSLC 915
                          + + P ++  +F +   +FL +FR++  +  E ++     +     
Sbjct: 317  MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376

Query: 916  LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
            +  F++V+ +G+  ++NL LA++  ++   N     E                     K 
Sbjct: 377  VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIE------------------AKE 418

Query: 976  TTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG 1035
              +     LL++  +   A+       + + T Y    P+  K+   +K   F   E   
Sbjct: 419  KMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYF--TPKKRKLFGNKKRKSFFLRESGK 476

Query: 1036 QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTW 1095
               PG             SD+D+  + +   L   +  S+           +     R  
Sbjct: 477  DQPPG-------------SDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRAL 523

Query: 1096 SQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIP 1155
            S VS    +  E   SQ         EP  P CGE         +        + +    
Sbjct: 524  SAVSILTITMKEQEKSQ---------EPCLP-CGENLASKYLVWNCCPQWLCVKKV---- 569

Query: 1156 DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMI 1215
             L   + DP   FTE  +  C                 +  T +  +EH   E    F  
Sbjct: 570  -LRTVMTDP---FTELAITIC----------------IIINTVFLAMEHHKMEA--SFEK 607

Query: 1216 LLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLD 1275
            +L+ G L F  I++ E                      M LK +A     YF   W   D
Sbjct: 608  MLNIGNLVFTSIFIAE----------------------MCLKIIALDPYHYFRRGWNIFD 645

Query: 1276 FLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 1335
             ++  +S   ++   L       ++S R LR  +  ++      +  ++   VGA+ S +
Sbjct: 646  SIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-L 704

Query: 1336 NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1395
             V+LV +IF  IFS++G+ LF   F                  N++   +  N TG    
Sbjct: 705  TVVLVIVIF--IFSVVGMQLFGRSF------------------NSQKSPKLCNPTGPTVS 744

Query: 1396 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1455
                 +  +    +L + ++   + W++ M+  +                  I F++  +
Sbjct: 745  CLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS-------LCVIVFILITV 796

Query: 1456 FGSFFTLNLFIGVIIDNFNQQKK 1478
             G    LNLFI +++++F+ +++
Sbjct: 797  IGKLVVLNLFIALLLNSFSNEER 819



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 66/339 (19%), Positives = 133/339 (39%), Gaps = 78/339 (23%)

Query: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +++    ++      + I   I+ N VF+A         + +        FT+I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSA-------LRTFRVLRA 226
           +KI+A    L  + + R  WN  D  V +++    F D+ N          LR+FRVLR 
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677

Query: 227 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTA 286
            K       L T++  +  SV  L  + V+ V  + +F+++G+QLF         R+F  
Sbjct: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF-- 727

Query: 287 LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGE 346
                                          N      LC  +    +C   +       
Sbjct: 728 -------------------------------NSQKSPKLCNPTGPTVSCLRHWH------ 750

Query: 347 NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYL 404
                      F  +FL +FR++  +  E +++  Q   ++  + +I F+L+  +G   +
Sbjct: 751 --------MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVV 802

Query: 405 VNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
           +NL +A++  ++  + +    E E ++ + Q A++  ++
Sbjct: 803 LNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/174 (22%), Positives = 83/174 (47%), Gaps = 22/174 (12%)

Query: 116  PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
            P +  +     I+   +F+++I+  I+ N + M    ++ P   K    ++ + F  I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410

Query: 170  FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGN----------VSAL 218
             E L+KI    F L  + F  + WN  D  V++++  +  +  L N             +
Sbjct: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465

Query: 219  RTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    + ++A++G+  F
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)

Query: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1572
            P N  +     +     F + I+  + +N V M       S      +A+   +F  I+ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171

Query: 1573 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
             E ++K+ A         +  + WN  D +V+ ++IV  +    I+        FRV R 
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229

Query: 1628 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1664
             +           +G +LR ++    +  L F   +S+ AL    L +            
Sbjct: 230  LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288

Query: 1665 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1700
                                 F +  I+      +  Y      I+  +N+  F N   S
Sbjct: 289  KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348

Query: 1701 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1760
             L +F++ T   W+ L    L T   Y                     + FF   I +  
Sbjct: 349  FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388

Query: 1761 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1810
              ++N+ +A++    ++A EE  + ++ +      E  EK   EA Q ++
Sbjct: 389  FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429



 Score = 31.6 bits (70), Expect = 8.2
 Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)

Query: 347  NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
            NP+ G     +F +FA + L LF++ T   W+ L    LRS               I   
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
            +F+  I +    +VN+ +AV+    E  N AT
Sbjct: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1323 bits (3424), Expect = 0.0
 Identities = 701/883 (79%), Positives = 721/883 (81%), Gaps = 92/883 (10%)

Query: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049
            QKPAALAAQGQLPSCIATPYSP        PP                    PE   VP 
Sbjct: 691  QKPAALAAQGQLPSCIATPYSP--------PP--------------------PETEKVPP 722

Query: 1050 AVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEAS 1109
               E+  ++ E+  + + G  E              P   P +   S        E  + 
Sbjct: 723  TRKETRFEEGEQPGQGTPGDPE--------------PVCVPIAVAESDTDDQEEDEENSL 768

Query: 1110 ASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFT 1169
             ++ +  +Q +++P + G    P+       +A  ++ AE      D  Q  K       
Sbjct: 769  GTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEP---- 824

Query: 1170 EGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYL 1229
                           QAPG         C                        AFEDIYL
Sbjct: 825  ---------------QAPG---------CGE----------------------AFEDIYL 838

Query: 1230 EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 1289
            EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN
Sbjct: 839  EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 898

Query: 1290 TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1349
            TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS
Sbjct: 899  TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 958

Query: 1350 IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1409
            IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY
Sbjct: 959  IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1018

Query: 1410 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469
            LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI
Sbjct: 1019 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1078

Query: 1470 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
            IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA
Sbjct: 1079 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1138

Query: 1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1589
            FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN
Sbjct: 1139 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1198

Query: 1590 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1649
            SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA
Sbjct: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258

Query: 1650 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1709
            LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT
Sbjct: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1318

Query: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769
            SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA
Sbjct: 1319 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1378

Query: 1770 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1812
            IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1379 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421



 Score = 1263 bits (3267), Expect = 0.0
 Identities = 630/630 (100%), Positives = 630/630 (100%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)

Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1364
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1365 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1399
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1400 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1452
             N       FD+    +LAL ++ T   W  +    + S G          +YM I+F++
Sbjct: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395

Query: 1453 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1501
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 77/303 (25%), Positives = 141/303 (46%), Gaps = 60/303 (19%)

Query: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVD 211
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++      ++A T  F +
Sbjct: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904

Query: 212  LGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964

Query: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998

Query: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047

Query: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107

Query: 439  EML 441
            + L
Sbjct: 1108 KKL 1110



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198

Query: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258

Query: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313

Query: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373

Query: 932  NLFLALLLSSFS 943
            N+++A++L +FS
Sbjct: 1374 NMYIAIILENFS 1385



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173

Query: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232

Query: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292

Query: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882
                                                SD+G  P             H  
Sbjct: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352

Query: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412

Query: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975
             ++   N     E  E         R Q  +  +K+
Sbjct: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906

Query: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966

Query: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026

Query: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086

Query: 947  LTAPDEDREMNNLQ 960
                 +D  M   Q
Sbjct: 1087 KKLGGQDIFMTEEQ 1100


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1121 bits (2900), Expect = 0.0
 Identities = 605/1259 (48%), Positives = 825/1259 (65%), Gaps = 78/1259 (6%)

Query: 674  EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
            EELE+S+  CP  W + A+ +LIW C P W+ +K+ V  ++M PFTDL + +CI+LN  F
Sbjct: 462  EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521

Query: 734  MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
            + LEHY M+ +   +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV   L
Sbjct: 522  LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581

Query: 794  MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
            +EL L+ ++ +++LR FR+LR+FKL K WPT   L+  + NS  AL +L L+L   +F  
Sbjct: 582  IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641

Query: 854  AVVGMQLFGKNYSEL---RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
            A  GM+LFGKNY E     D D   LPRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 642  AAFGMKLFGKNYEEFVCHIDKDC-QLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700

Query: 911  GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
            GQS C+  +L+V++IGNL+VL LFLAL+ S  S  ++TA +E+ E  NLQLA+ARI++G+
Sbjct: 701  GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759

Query: 971  RFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEE 1030
             +V        C                                +T+ VP   K+T    
Sbjct: 760  NYV---LLKILC--------------------------------KTQNVP---KDTMDHV 781

Query: 1031 GEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP---E 1087
             E   +    D       ++   +  D  ++ E++S GTE+ ++ + ESQ +   P   E
Sbjct: 782  NEVYVKEDISDH-----TLSELSNTQDFLKDKEKSS-GTEKNAT-ENESQSLIPSPSVSE 834

Query: 1088 APPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNT 1147
              P +   S +    + E ++ +     +++ K            + S SE ST D+  +
Sbjct: 835  TVPIASGESDIENLDNKEIQSKSGDGGSKEKIK------------QSSSSECSTVDIAIS 882

Query: 1148 AELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1207
             E  E++   G+  K        GC R      +      GK+W  +RKTC  IVE++WF
Sbjct: 883  EE--EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWF 936

Query: 1208 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYF 1267
            + FI  + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF
Sbjct: 937  KCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYF 996

Query: 1268 TNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1327
            +N W  LDF++V V  +SL+  T        +K L +++ LRPLR LS+FE M+VVV AL
Sbjct: 997  SNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRAL 1051

Query: 1328 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL 1387
            +      +NV LVCL+ WLIFSIMGV+LFAG+F  CI+ T G+     + V NKS+CESL
Sbjct: 1052 IKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE-RFPSSEVMNKSRCESL 1110

Query: 1388 NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMY 1447
                 + W   K+NFDNVG G+L+LLQVATF GW+ IM +A+DS     QP +E N+YMY
Sbjct: 1111 LFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMY 1170

Query: 1448 IYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ 1507
             YF+ FIIFG F  L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y  +KKL  +  Q
Sbjct: 1171 CYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230

Query: 1508 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLF 1567
            +P+PRPLNK QGFIFD+VT QAF+V +M LIC   + MM++TD QS +    L  IN +F
Sbjct: 1231 RPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIF 1290

Query: 1568 VAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
            V ++T ECI+KL A R +YFT +WNIFDF+VVI SI G  L   +  Y   P+L ++I L
Sbjct: 1291 VMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350

Query: 1628 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAG 1687
            +RI  +LRL +G K    L+  LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAG
Sbjct: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAG 1410

Query: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPA 1746
            I+D+ NF+TF NSMLCLFQ+   AGWDG+L  I N+    CDP   N     RGDCG+P+
Sbjct: 1411 INDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPS 1470

Query: 1747 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEAT 1806
            VGI +F +YI+IS+LI+VNMYI +++E  ++A+++  + LSEDDF  F+++W++FDP+ T
Sbjct: 1471 VGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRT 1530

Query: 1807 QFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESG 1866
            Q+I+ S LSDFA AL  PL +AKPN+  LI +DLPM  GDRIHC+DIL AFTKRV+G+  
Sbjct: 1531 QYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDV 1590

Query: 1867 EMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1925
             M+ +  ++E  F+ ANP KI+ EPITTTL+RK E VSA +IQRA++ + L+R+ K+ S
Sbjct: 1591 RMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649



 Score =  383 bits (983), Expect = e-105
 Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)

Query: 16  FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
           FT+ES   I++ +A+       T  E  E    EE  +P  DL+  KKLP +YGN  Q +
Sbjct: 13  FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61

Query: 76  IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
           + EPLED+DP+Y  +K TFIVLNK +TIFRF+A + L  LSPF+ IRR  +K+LVH  F 
Sbjct: 62  VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121

Query: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
           + I+ ++L +CVFM+  + P W   +E T   IYTFE LVK+ ARG    +F+FL DPWN
Sbjct: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181

Query: 195 WLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVM 254
           WLDFSV +      +  L  +  L+T R LR LK I +  GLK++VG LI  +K+L  V+
Sbjct: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241

Query: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
           +LT+F LS+F+LIG+ LFMGNL+HKC R      N T  N T                Y+
Sbjct: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289

Query: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
            + EN+    G    LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA  ALFRL
Sbjct: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349

Query: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
           M QD  E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q     ++
Sbjct: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409

Query: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
           + E +FQ+  + L++ +E       D      +EM   +P+++
Sbjct: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446



 Score =  132 bits (332), Expect = 3e-30
 Identities = 154/689 (22%), Positives = 291/689 (42%), Gaps = 149/689 (21%)

Query: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
            +R+T   ++ H +F+ FI+  +L+    ++  ++     K   VL      ++T+  +++
Sbjct: 107  IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162

Query: 1254 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1313
            +  + V  G   +  + W WLDF +    ++      + ++ +  I +L+T R LR L+ 
Sbjct: 163  LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216

Query: 1314 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1372
            +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G    +C    +    
Sbjct: 217  IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272

Query: 1373 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1429
                    +++ E+L N TG  Y+ +   NF  + G  Y  L    T  G     Y  V 
Sbjct: 273  --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324

Query: 1430 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1460
                        DS G+          ++ P+  Y+  +Y       I+FV+     SF+
Sbjct: 325  AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384

Query: 1461 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1503
              +LF+G++   + ++K+++G                 Q+   T+E K     MKK    
Sbjct: 385  MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444

Query: 1504 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1527
                                +K +K  P    K+                + F+  I+  
Sbjct: 445  STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504

Query: 1528 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-Y 1586
               D+ ++  I LN+  + +E    S +   +L   NL+F+ IFT E I K+ A+  Y Y
Sbjct: 505  PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564

Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTL 1646
            F   WNIFD ++V   ++   L+++            ++RL R+ RI +L +     + L
Sbjct: 565  FQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQIL 616

Query: 1647 LFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFAN 1699
            +++L  S  AL ++ LLLF  +F  + FGM  F   Y ++   ID       ++   F +
Sbjct: 617  MWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676

Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
            S L +F+I      + L   +   G  +C P                    F+   I+I 
Sbjct: 677  SFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIG 716

Query: 1760 FLIVVNMYIAIILENFS----VATEESTE 1784
             L+V+ +++A++  +FS    V  EE+ E
Sbjct: 717  NLLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)

Query: 646  QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
            Q+   DG  +   +Q + S  S +  A+ E EE       S+H    C   + L Q    
Sbjct: 854  QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913

Query: 697  WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
             +   +W +I++    +V + +    I +  +L+T  +A E   M      + +L+  ++
Sbjct: 914  SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973

Query: 755  VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
            +FT IF  EM  K +A     YF  GW   D ++VI+  + L       L  L S + LR
Sbjct: 974  IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033

Query: 815  VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
              ++   +  +  +++ +  +     N+ LV  +I  IF+++G+ LF   + E  D  SG
Sbjct: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 69/351 (19%), Positives = 146/351 (41%), Gaps = 67/351 (19%)

Query: 120  IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
            IR+   KI+ ++ F   I + T+L+        ++M Q        +Y +  FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN--VSALRTFRVLRALKT 229
             L+K +A GF      +  + W  LDF V+++ +    +      +  L + + LR L+ 
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
            +S    +K +V ALI++     +V ++ +    +F+++G+ LF G       R +  ++ 
Sbjct: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDP 1090

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
            T+G                  P + ++     + LL   S                EN  
Sbjct: 1091 TSGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN-- 1120

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFL 399
                +FD+    FL+L ++ T + W  +    + S            IYM  +F+  I  
Sbjct: 1121 -AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIF 1179

Query: 400  GSFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
            G F  +++++ V+   + +       + I  T ++ K+++   +++ ++ +
Sbjct: 1180 GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 54/235 (22%), Positives = 93/235 (39%), Gaps = 43/235 (18%)

Query: 48  EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
           E+   R + +L+ SKK+  LY                 +Y   KTF++ N      +   
Sbjct: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496

Query: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
                +++PF  +               LI+C IL  C    +H P              
Sbjct: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542

Query: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTE--FVDLGNVSALRT 220
            F  I+T E + KI+A    +H + + +  WN  D S+I+     E    ++  ++ LR 
Sbjct: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFD-SMIVFHGLIELCLANVAGMALLRL 597

Query: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
           FR+LR  K        + ++ +L  S   L D+++L    +   A  G++LF  N
Sbjct: 598 FRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)

Query: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
           V++ PF  L I + ++++ +FM+L      +   +   V      GI+T E+  K+ A  
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167

Query: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
                + +    WN  D  + +  ++ +  S +  +  L++ R LR+ K+      L +L
Sbjct: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226

Query: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
           + ++ + +  L  + ++    + IF+++GM LF  N
Sbjct: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262



 Score = 34.7 bits (78), Expect = 0.97
 Identities = 33/172 (19%), Positives = 70/172 (40%), Gaps = 20/172 (11%)

Query: 116  PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK------YVEYTFTAIYT 169
            P + ++     ++    FN+++M  I    + M         +      ++   F  +YT
Sbjct: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYT 1295

Query: 170  FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYT---------TEFVDLGNVSALRT 220
             E ++K++A  F    FT     WN  DF V+I + T         +  V    V  +  
Sbjct: 1296 MECILKLIA--FRCFYFTIA---WNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350

Query: 221  FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
             R++  L+          ++  L+ S+  L ++++L    + ++A+ G+  F
Sbjct: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  455 bits (1170), Expect = e-127
 Identities = 334/1155 (28%), Positives = 569/1155 (49%), Gaps = 104/1155 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025

Query: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085

Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143

Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203

Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
            EM +K VA    +G + Y  ++W  LD L+V +S    LVS+V+++ G   +G ++ LR 
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382

Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
            LR LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441

Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
               +G+   N T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491

Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
            MY  +D+ G ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551

Query: 1485 IFMTEEQKKYYNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLI 1538
                 E+K+     KK  SK+ Q      KP     ++++  +  + T    D+ I  +I
Sbjct: 1552 A-RRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1610

Query: 1539 CLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596
             LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D 
Sbjct: 1611 GLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669

Query: 1597 VVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654
             +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +L
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729

Query: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709
            P + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789

Query: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769
               W+G++   L      CD            C +  +  ++F ++++ +  ++VN+ IA
Sbjct: 1790 GDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1837

Query: 1770 IILENFSVATEESTE 1784
            +++++   + +E+ E
Sbjct: 1838 VLMKHLEESNKEAKE 1852



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  125 bits (314), Expect = 4e-28
 Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028

Query: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087

Query: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200

Query: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277

Query: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337

Query: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397

Query: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+  +        
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457

Query: 878  ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
               RW  H  +F +   A + +F +   + W++ M+D ++  G             LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517

Query: 920  LLVMVIGNLVVLNLFLALLLSSF 942
            +  ++I    VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 4e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  EHEA 447
            +  +
Sbjct: 1566 KRRS 1569



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1706 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1750

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1751 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1770

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1771 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1875



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score =  455 bits (1170), Expect = e-127
 Identities = 334/1155 (28%), Positives = 569/1155 (49%), Gaps = 104/1155 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025

Query: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085

Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143

Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203

Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
            EM +K VA    +G + Y  ++W  LD L+V +S    LVS+V+++ G   +G ++ LR 
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382

Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
            LR LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441

Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
               +G+   N T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491

Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
            MY  +D+ G ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551

Query: 1485 IFMTEEQKKYYNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLI 1538
                 E+K+     KK  SK+ Q      KP     ++++  +  + T    D+ I  +I
Sbjct: 1552 A-RRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1610

Query: 1539 CLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596
             LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D 
Sbjct: 1611 GLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDL 1669

Query: 1597 VVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654
             +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +L
Sbjct: 1670 AIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQAL 1729

Query: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709
            P + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T
Sbjct: 1730 PQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVST 1789

Query: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769
               W+G++   L      CD            C +  +  ++F ++++ +  ++VN+ IA
Sbjct: 1790 GDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1837

Query: 1770 IILENFSVATEESTE 1784
            +++++   + +E+ E
Sbjct: 1838 VLMKHLEESNKEAKE 1852



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  125 bits (314), Expect = 4e-28
 Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028

Query: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087

Query: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200

Query: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277

Query: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337

Query: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397

Query: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+  +        
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457

Query: 878  ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
               RW  H  +F +   A + +F +   + W++ M+D ++  G             LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517

Query: 920  LLVMVIGNLVVLNLFLALLLSSF 942
            +  ++I    VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 4e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  EHEA 447
            +  +
Sbjct: 1566 KRRS 1569



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1706 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1750

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1751 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1770

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1771 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1875



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score =  454 bits (1169), Expect = e-127
 Identities = 332/1149 (28%), Positives = 566/1149 (49%), Gaps = 99/1149 (8%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025

Query: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085

Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143

Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203

Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
            EM +K VA    +G + Y  ++W  LD L+V +S    LVS+V+++ G   +G ++ LR 
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382

Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
            LR LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441

Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
               +G+   N T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491

Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
            MY  +D+ G ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551

Query: 1485 IFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVT 1544
                EE  K    ++K   K   KP     ++++  +  + T    D+ I  +I LN+VT
Sbjct: 1552 ARRREE--KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1609

Query: 1545 MMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILS 1602
            M +E   Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LS
Sbjct: 1610 MAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLS 1668

Query: 1603 IVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660
            I+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+
Sbjct: 1669 IMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNL 1728

Query: 1661 GLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDG 1715
            GLL  L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G
Sbjct: 1729 GLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNG 1788

Query: 1716 LLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1775
            ++   L      CD            C +  +  ++F ++++ +  ++VN+ IA+++++ 
Sbjct: 1789 IMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1836

Query: 1776 SVATEESTE 1784
              + +E+ E
Sbjct: 1837 EESNKEAKE 1845



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  125 bits (314), Expect = 4e-28
 Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028

Query: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087

Query: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200

Query: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277

Query: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337

Query: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397

Query: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+  +        
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457

Query: 878  ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
               RW  H  +F +   A + +F +   + W++ M+D ++  G             LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517

Query: 920  LLVMVIGNLVVLNLFLALLLSSF 942
            +  ++I    VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (253), Expect = 5e-21
 Identities = 87/361 (24%), Positives = 153/361 (42%), Gaps = 79/361 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  E 444
            +
Sbjct: 1566 K 1566



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1583 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1642

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1643 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1698

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1699 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1743

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1744 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1763

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1764 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1821

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1822 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1868



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  450 bits (1158), Expect = e-126
 Identities = 322/1160 (27%), Positives = 554/1160 (47%), Gaps = 138/1160 (11%)

Query: 702  LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761
            LW++    ++ +V   +    I M I++NTL M +E++    E    L++ N+VFT +F 
Sbjct: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837

Query: 762  AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821
             EM  K++A  P  Y +  +NIFD IIV++S+ E+       LSVLR+FRLLRV KL + 
Sbjct: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897

Query: 822  WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881
             P L   + ++  ++  +     +L + +FIF+++GM LFG  +S   D+   +  R + 
Sbjct: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957

Query: 882  MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940
                 A + +F+IL  E W   +++ M  S  S   L F+ +M  GN V+ NL +A+L+ 
Sbjct: 958  DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016

Query: 941  SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA 997
             F A+   N +  DED+   + +    +    LR ++ T    C   L   P     L  
Sbjct: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCS--LAVTPN--GHLEG 1068

Query: 998  QGQL--PSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESD 1055
            +G L  P  + T  +P P  T K  P           + G  + GDP             
Sbjct: 1069 RGSLSPPLIMCTAATPMP--TPKSSPFLDAAPSLPDSRRGSSSSGDPP------------ 1114

Query: 1056 TDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSR--TWSQVSATASSE-------- 1105
                       LG ++  +  + S     GP     SR  +WS +    S +        
Sbjct: 1115 -----------LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGER 1163

Query: 1106 -----AEASASQADWRQQWKAEPQAPGCGETP------------------EDSCSEGSTA 1142
                  E   S  D  +  +A   APG   TP                     C +    
Sbjct: 1164 ESLLSGEGKGSTDDEAEDGRA---APGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQ 1220

Query: 1143 DMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW---------- 1192
             +   ++   +I    +D  + +D   + C     C  +     P K  W          
Sbjct: 1221 VVALPSDFFLRIDSHREDAAELDDDSEDSC-----CLRLHKVLEPYKPQWCRSREAWALY 1275

Query: 1193 ------RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1246
                  R R +C  ++ H  F+  ++  I L+   +A E   ++   T +V L  ++ +F
Sbjct: 1276 LFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIF 1335

Query: 1247 TYVFVLEMLLKWVAYGFKK----YFTNAWCWLDFLIVDVSLVSLV---ANTLGFAEMGPI 1299
            T +FV EM++K VA G       Y  ++W  LD L+V VSLV +V   A+  G   +G +
Sbjct: 1336 TAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVL 1395

Query: 1300 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1359
            + LR LR LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GK
Sbjct: 1396 RVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGK 1455

Query: 1360 FGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFK 1419
            F  C    EG    N   ++ K+QC + +      W + K NFDN+G   ++L  +++  
Sbjct: 1456 FYYC----EGPDTRN---ISTKAQCRAAHYR----WVRRKYNFDNLGQALMSLFVLSSKD 1504

Query: 1420 GWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1479
            GW++IMY  +D+ G ++QP   +N +M +YF+ F++  SFF LN+F+GV+++NF++ ++ 
Sbjct: 1505 GWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1564

Query: 1480 LGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLIC 1539
               ++    EE  K    +++   K  ++P     +  +  I  + T    D+ I F+IC
Sbjct: 1565 QEAEEARRREE--KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIIC 1622

Query: 1540 LNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVV 1598
            +N++TM +E  +Q       L   N +F  +F  E  +KL A     +F + WN  D  +
Sbjct: 1623 VNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAI 1682

Query: 1599 VILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPA 1656
            V+LS++G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  ++ +LP 
Sbjct: 1683 VLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1742

Query: 1657 LFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSA 1711
            + N+GLL  L+ FIY+  G+  F  ++        G+     F  F  + L LF+++T  
Sbjct: 1743 VGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGD 1802

Query: 1712 GWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS--PAVGILFFTTYIIISFLIVVNMYIA 1769
             W+G++             TL   +     C S  PA+  ++F T+++++  ++VN+ +A
Sbjct: 1803 NWNGIMK-----------DTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA 1851

Query: 1770 IILENFSVATEESTEPLSED 1789
            +++++   + +E+ E    D
Sbjct: 1852 VLMKHLEESNKEAREDAELD 1871



 Score =  142 bits (357), Expect = 4e-33
 Identities = 201/889 (22%), Positives = 352/889 (39%), Gaps = 190/889 (21%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G       ++R+P+N  D  +I++    E V    G +S LRTFR+LR LK +  +  L+
Sbjct: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
                            + LK  T D +                       PD    +FDS
Sbjct: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019

Query: 418  EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463
             +  A  ++T+E       E+ F +  E+    LK    A+T    + G  ++S   +  
Sbjct: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079

Query: 464  SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513
            +   P+ + +              RR   SSG    G D+ P +     P A    S   
Sbjct: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138

Query: 514  GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573
               R+S    SS G   + +RR    E      E+  +GE +               S  
Sbjct: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176

Query: 574  GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633
             +   G +APG      + +                E+  P    LRP  L  PP  T  
Sbjct: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214

Query: 634  SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692
             +  G    L S     +D   E  A     S  S      + LE  +    P W R  +
Sbjct: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270

Query: 693  RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750
             + ++   P     +   + V+     D  + + I LN + +ALE  ++     E   L 
Sbjct: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329

Query: 751  VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798
            V N +FT IF AEM  K++AL      + Y Q  WN+ D ++V++SL+++        G 
Sbjct: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389

Query: 799  SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858
              +  L VLR  R LR  ++    P L  +++ + +S+  +GN+ L+      IF ++G+
Sbjct: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449

Query: 859  QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902
            QLF GK Y             ++ R +    + R +  D     L+   +L  +  W+  
Sbjct: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509

Query: 903  MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
            M+D ++  G             LL F+  ++I +  VLN+F+ +++ +F
Sbjct: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  114 bits (286), Expect = 7e-25
 Identities = 81/316 (25%), Positives = 150/316 (47%), Gaps = 24/316 (7%)

Query: 674  EELEESRHKCPPCWNRLAQRYLIWECCPLWMSI---KQGVKLVVMDPFTDLTITMCIVLN 730
            +E EE+R +      RL +R    +  P +      ++ +  +    + DL IT  I +N
Sbjct: 1565 QEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVN 1624

Query: 731  TLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVI 790
             + M++EHYN     +E L+  N VFT +F  E   K++A     +F+  WN  D  IV+
Sbjct: 1625 VITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL 1684

Query: 791  LSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 840
            LSLM + L  +          + + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 1685 LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1744

Query: 841  NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-W 899
            NL L+  ++ FI+A +G++LFG+      +   GL       +F  AFL +FR+  G+ W
Sbjct: 1745 NLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNW 1804

Query: 900  IETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTA 949
               M D +    +          +L  + F+  +++   V++N+ +A+L+      N  A
Sbjct: 1805 NGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA 1864

Query: 950  PDEDREMNNLQLALAR 965
             ++      ++L +A+
Sbjct: 1865 REDAELDAEIELEMAQ 1880



 Score =  109 bits (273), Expect = 2e-23
 Identities = 89/356 (25%), Positives = 168/356 (47%), Gaps = 49/356 (13%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E ++K++A G       +L D WN LDF +++       +D  NVS  A+RT RVLR L
Sbjct: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267

Query: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323

Query: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383

Query: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439



 Score =  103 bits (256), Expect = 2e-21
 Identities = 87/362 (24%), Positives = 156/362 (43%), Gaps = 79/362 (21%)

Query: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------L 212
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++     V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 213  GNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            G +  LR  R LR L+ IS   GLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332
             G                                Y   P+               N S  
Sbjct: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470

Query: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523

Query: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581

Query: 442  KK 443
            ++
Sbjct: 1582 ER 1583



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D     
Sbjct: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1302
             F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++  G    + ++
Sbjct: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198

Query: 1303 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1361
            RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    
Sbjct: 199  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258

Query: 1362 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1394
            RC   +      N T +                     N   +C        L +   L 
Sbjct: 259  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318

Query: 1395 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1432
            W    +   + VGA   A +    +                 + +I YA       +   
Sbjct: 319  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378

Query: 1433 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489
            G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K++   +   M E
Sbjct: 379  GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435

Query: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
            ++ ++ +    L S          L KY G IF  V +++
Sbjct: 436  QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)

Query: 1188 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1247
            G++W         IV+  +F   I+  IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1248 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1307
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G A+ G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888

Query: 1308 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1367
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946

Query: 1368 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427
             GD     T+ + K                   NFD++    + + Q+ T + W  ++Y 
Sbjct: 947  TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981

Query: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1476
                 G      W       +YFV  + FG++   NL + ++++ F  +
Sbjct: 982  ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 1517 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1576
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1577 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1632
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890

Query: 1633 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1687
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1747
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990

Query: 1748 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1796
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 71.2 bits (173), Expect = 9e-12
 Identities = 41/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656

Query: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGN--------VSALR 219
            E+ +K++A GF      F +D WN LD +++   +M  T E +++          +  +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712

Query: 220  TFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
              R+ R LK + + +G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768
           +V +P+ +    + I+LN     +F   E     SE   +L+  +      F  EM  K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824
           +AL  +    Y    WN  D  IV+  +ME  L   + +LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
           +  L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1579
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1580 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1635
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208

Query: 1636 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 1773 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1832

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 1833 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1869



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423


>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
            isoform 1 [Homo sapiens]
          Length = 2377

 Score =  449 bits (1156), Expect = e-125
 Identities = 334/1165 (28%), Positives = 568/1165 (48%), Gaps = 113/1165 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025

Query: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085

Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143

Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203

Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
            EM +K VA    +G + Y  ++W  LD L+V +S    LVS+V+++ G   +G ++ LR 
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382

Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
            LR LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441

Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
               +G+   N T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491

Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
            MY  +D+ G ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551

Query: 1485 IFMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQ 1528
                EE      +KK  N M              S+   KP     ++++  +  + T  
Sbjct: 1552 ARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSH 1611

Query: 1529 AFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYY 1586
              D+ I  +I LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +
Sbjct: 1612 YLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRF 1670

Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1644
            F + WN  D  +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730

Query: 1645 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFAN 1699
             LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1790

Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
            + L LF+++T   W+G++   L      CD            C +  +  ++F ++++ +
Sbjct: 1791 AFLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTA 1838

Query: 1760 FLIVVNMYIAIILENFSVATEESTE 1784
              ++VN+ IA+++++   + +E+ E
Sbjct: 1839 QFVLVNVVIAVLMKHLEESNKEAKE 1863



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  125 bits (314), Expect = 4e-28
 Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028

Query: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087

Query: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200

Query: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277

Query: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337

Query: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397

Query: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+  +        
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457

Query: 878  ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
               RW  H  +F +   A + +F +   + W++ M+D ++  G             LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517

Query: 920  LLVMVIGNLVVLNLFLALLLSSF 942
            +  ++I    VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  103 bits (257), Expect = 2e-21
 Identities = 89/370 (24%), Positives = 156/370 (42%), Gaps = 79/370 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  EHEALTIRGV 453
            +   L +  V
Sbjct: 1566 KRRNLMLDDV 1575



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
            isoform 4 [Homo sapiens]
          Length = 2332

 Score =  449 bits (1156), Expect = e-125
 Identities = 334/1165 (28%), Positives = 568/1165 (48%), Gaps = 113/1165 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025

Query: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085

Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143

Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203

Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
            EM +K VA    +G + Y  ++W  LD L+V +S    LVS+V+++ G   +G ++ LR 
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382

Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
            LR LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441

Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
               +G+   N T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491

Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
            MY  +D+ G ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551

Query: 1485 IFMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQ 1528
                EE      +KK  N M              S+   KP     ++++  +  + T  
Sbjct: 1552 ARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSH 1611

Query: 1529 AFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYY 1586
              D+ I  +I LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +
Sbjct: 1612 YLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRF 1670

Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1644
            F + WN  D  +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730

Query: 1645 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFAN 1699
             LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1790

Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
            + L LF+++T   W+G++   L      CD            C +  +  ++F ++++ +
Sbjct: 1791 AFLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTA 1838

Query: 1760 FLIVVNMYIAIILENFSVATEESTE 1784
              ++VN+ IA+++++   + +E+ E
Sbjct: 1839 QFVLVNVVIAVLMKHLEESNKEAKE 1863



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  125 bits (314), Expect = 4e-28
 Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028

Query: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087

Query: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200

Query: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277

Query: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337

Query: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397

Query: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+  +        
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457

Query: 878  ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
               RW  H  +F +   A + +F +   + W++ M+D ++  G             LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517

Query: 920  LLVMVIGNLVVLNLFLALLLSSF 942
            +  ++I    VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  103 bits (257), Expect = 2e-21
 Identities = 89/370 (24%), Positives = 156/370 (42%), Gaps = 79/370 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  EHEALTIRGV 453
            +   L +  V
Sbjct: 1566 KRRNLMLDDV 1575



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
            isoform 8 [Homo sapiens]
          Length = 2284

 Score =  449 bits (1156), Expect = e-125
 Identities = 334/1165 (28%), Positives = 568/1165 (48%), Gaps = 113/1165 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025

Query: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085

Query: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143

Query: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203

Query: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVS----LVSLVANTLGFAEMGPIKSLRT 1304
            EM +K VA    +G + Y  ++W  LD L+V +S    LVS+V+++ G   +G ++ LR 
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDS-GTKILGMLRVLRL 1382

Query: 1305 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCI 1364
            LR LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC- 1441

Query: 1365 NQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDI 1424
               +G+   N T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DI
Sbjct: 1442 ---QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDI 1491

Query: 1425 MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQD 1484
            MY  +D+ G ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++
Sbjct: 1492 MYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEE 1551

Query: 1485 IFMTEE------QKKYYNAM----------KKLGSKKPQKPIPRPLNKYQGFIFDIVTKQ 1528
                EE      +KK  N M              S+   KP     ++++  +  + T  
Sbjct: 1552 ARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSH 1611

Query: 1529 AFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYY 1586
              D+ I  +I LN+VTM +E   Q P+ ++   KI N +F  IF  E + KL A     +
Sbjct: 1612 YLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRF 1670

Query: 1587 FTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1644
            F + WN  D  +V+LSI+G  L +I        +PT+ R++R+ RI R+L+L++ A G+R
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730

Query: 1645 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFAN 1699
             LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +      G+     F+ F  
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1790

Query: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
            + L LF+++T   W+G++   L      CD            C +  +  ++F ++++ +
Sbjct: 1791 AFLTLFRVSTGDNWNGIMKDTLRD----CD--------QESTCYNTVISPIYFVSFVLTA 1838

Query: 1760 FLIVVNMYIAIILENFSVATEESTE 1784
              ++VN+ IA+++++   + +E+ E
Sbjct: 1839 QFVLVNVVIAVLMKHLEESNKEAKE 1863



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  125 bits (314), Expect = 4e-28
 Identities = 194/923 (21%), Positives = 358/923 (38%), Gaps = 226/923 (24%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968

Query: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028

Query: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087

Query: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147

Query: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200

Query: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234

Query: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277

Query: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337

Query: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397

Query: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLP------- 877
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+  +        
Sbjct: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAE 1457

Query: 878  ---RW--HMMDFFH---AFLIIFRILCGE-WIETMWDCMEVSG---------QSLCLLVF 919
               RW  H  +F +   A + +F +   + W++ M+D ++  G             LL F
Sbjct: 1458 ASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYF 1517

Query: 920  LLVMVIGNLVVLNLFLALLLSSF 942
            +  ++I    VLN+F+ +++ +F
Sbjct: 1518 ISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  103 bits (257), Expect = 2e-21
 Identities = 89/370 (24%), Positives = 156/370 (42%), Gaps = 79/370 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  EHEALTIRGV 453
            +   L +  V
Sbjct: 1566 KRRNLMLDDV 1575



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1601 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1660

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1661 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1716

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1717 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1761

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1762 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1781

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1782 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1839

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1840 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1886



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  449 bits (1155), Expect = e-125
 Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
            F A+   A   + E +    +L     G    K+     C  L  L + P+   +L    
Sbjct: 967  FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012

Query: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
             LP  I    ATP S P   +    E + P  + T      +PG     +  P       
Sbjct: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071

Query: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
             P + A S T        NSLG                  S + QESQ      E    S
Sbjct: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129

Query: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
               S      S E EA +S    D  Q       A G G   E     G +A       L
Sbjct: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189

Query: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
                P L  D  D E   ++G         R P C ++       ++    R R  C+ I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249

Query: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
            + H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA 
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
            G+    + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
            SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425

Query: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
             T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G 
Sbjct: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
            ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++     E+K+ 
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537

Query: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
                KK  SK+ Q      KP     ++++  +  + T    D+ I  +I LN+VTM +E
Sbjct: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597

Query: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
               Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LSI+G 
Sbjct: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656

Query: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
             L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL 
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716

Query: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
             L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G++  
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776

Query: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
             L      CD            C +  +  ++F ++++ +  ++VN+ IA+++++   + 
Sbjct: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824

Query: 1780 EESTE 1784
            +E+ E
Sbjct: 1825 KEAKE 1829



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  132 bits (332), Expect = 3e-30
 Identities = 195/900 (21%), Positives = 352/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  115 bits (288), Expect = 4e-25
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841



 Score =  102 bits (254), Expect = 4e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)

Query: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756

Query: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814

Query: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869

Query: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904

Query: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952

Query: 1459 FFTLNLFIGVIIDNFNQQ 1476
            +   NL + ++++ F  +
Sbjct: 953  YVLFNLLVAILVEGFQAE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  449 bits (1155), Expect = e-125
 Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
            F A+   A   + E +    +L     G    K+     C  L  L + P+   +L    
Sbjct: 967  FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012

Query: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
             LP  I    ATP S P   +    E + P  + T      +PG     +  P       
Sbjct: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071

Query: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
             P + A S T        NSLG                  S + QESQ      E    S
Sbjct: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129

Query: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
               S      S E EA +S    D  Q       A G G   E     G +A       L
Sbjct: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189

Query: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
                P L  D  D E   ++G         R P C ++       ++    R R  C+ I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249

Query: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
            + H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA 
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
            G+    + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
            SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425

Query: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
             T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G 
Sbjct: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
            ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++     E+K+ 
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537

Query: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
                KK  SK+ Q      KP     ++++  +  + T    D+ I  +I LN+VTM +E
Sbjct: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597

Query: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
               Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LSI+G 
Sbjct: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656

Query: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
             L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL 
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716

Query: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
             L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G++  
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776

Query: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
             L      CD            C +  +  ++F ++++ +  ++VN+ IA+++++   + 
Sbjct: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824

Query: 1780 EESTE 1784
            +E+ E
Sbjct: 1825 KEAKE 1829



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  132 bits (332), Expect = 3e-30
 Identities = 195/900 (21%), Positives = 352/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  115 bits (288), Expect = 4e-25
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841



 Score =  102 bits (254), Expect = 4e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)

Query: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756

Query: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814

Query: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869

Query: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904

Query: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952

Query: 1459 FFTLNLFIGVIIDNFNQQ 1476
            +   NL + ++++ F  +
Sbjct: 953  YVLFNLLVAILVEGFQAE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  449 bits (1155), Expect = e-125
 Identities = 330/1145 (28%), Positives = 563/1145 (49%), Gaps = 107/1145 (9%)

Query: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907

Query: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966

Query: 942  FSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQKPAALAAQG 999
            F A+   A   + E +    +L     G    K+     C  L  L + P+   +L    
Sbjct: 967  FQAEG-DANKSESEPDFFSPSLD----GDGDRKK-----CLALVSLGEHPELRKSL---- 1012

Query: 1000 QLPSCI----ATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QGTPGDPEPVC 1046
             LP  I    ATP S P   +    E + P  + T      +PG     +  P       
Sbjct: 1013 -LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPH 1071

Query: 1047 VPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVSGGPEAPPDS 1092
             P + A S T        NSLG                  S + QESQ      E    S
Sbjct: 1072 SPWSAASSWTS--RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERAS 1129

Query: 1093 RTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAEL 1150
               S      S E EA +S    D  Q       A G G   E     G +A       L
Sbjct: 1130 PAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1189

Query: 1151 LEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---WRLRKTCYHI 1201
                P L  D  D E   ++G         R P C ++       ++    R R  C+ I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249

Query: 1202 VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 1261
            + H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ EM +K VA 
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309

Query: 1262 GF----KKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRAL 1314
            G+    + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR LR LRPLR +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369

Query: 1315 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLN 1374
            SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C    +G+   N
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRN 1425

Query: 1375 YTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGY 1434
             T   NKS C   +      W + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G 
Sbjct: 1426 IT---NKSDCAEASYR----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 1435 EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1494
            ++QP   +N +M +YF+ F++  +FF LN+F+GV+++NF++ ++    ++     E+K+ 
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRL 1537

Query: 1495 YNAMKKLGSKKPQ------KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548
                KK  SK+ Q      KP     ++++  +  + T    D+ I  +I LN+VTM +E
Sbjct: 1538 RRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1597

Query: 1549 TDDQSPEKINILAKI-NLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGT 1606
               Q P+ ++   KI N +F  IF  E + KL A     +F + WN  D  +V+LSI+G 
Sbjct: 1598 -HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1656

Query: 1607 VLSDI--IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1664
             L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL 
Sbjct: 1657 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1716

Query: 1665 FLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1719
             L+ FI++  G+  F  ++ +      G+     F+ F  + L LF+++T   W+G++  
Sbjct: 1717 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1776

Query: 1720 ILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779
             L      CD            C +  +  ++F ++++ +  ++VN+ IA+++++   + 
Sbjct: 1777 TLRD----CD--------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824

Query: 1780 EESTE 1784
            +E+ E
Sbjct: 1825 KEAKE 1829



 Score =  144 bits (362), Expect = 1e-33
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127

Query: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180

Query: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 1363 CINQTEGDLP-------------------------------------------------L 1373
            C       LP                                                 L
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407

Query: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
             M E++ ++ +    L S          L KY  +I
Sbjct: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  132 bits (332), Expect = 3e-30
 Identities = 195/900 (21%), Positives = 352/900 (39%), Gaps = 203/900 (22%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRP 621
            R +      P T   PG  LH      G  +   DCNG             S    L R 
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG------------KSASGRLARA 1188

Query: 622  VMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRH 681
            +  + PP     +++              +G    G R RA     +    LE    S +
Sbjct: 1189 LRPDDPPLDGDDADD--------------EGNLSKGERVRAWIRARLPACCLERDSWSAY 1234

Query: 682  KCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741
              PP       R+ +                ++     D  + + I LN + +A+E   +
Sbjct: 1235 IFPP-----QSRFRLL------------CHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1277

Query: 742  TSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY----YFQQGWNIFDSIIVILSLME 795
                 E   L + N +FT +F AEMT K++AL   +    Y +  WN+ D ++V++S+++
Sbjct: 1278 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1337

Query: 796  LGLSRMSN--------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
            + +S +S+        L VLR  R LR  ++      L  +++ + +S+  +GN+ ++  
Sbjct: 1338 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1397

Query: 848  IIVFIFAVVGMQLFGKNYSELRDSDSGLLP----------RW--HMMDFFH---AFLIIF 892
                IF ++G+QLF   +   +  D+  +           RW  H  +F +   A + +F
Sbjct: 1398 AFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLF 1457

Query: 893  RILCGE-WIETMWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942
             +   + W++ M+D ++  G             LL F+  ++I    VLN+F+ +++ +F
Sbjct: 1458 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  118 bits (296), Expect = 5e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  115 bits (288), Expect = 4e-25
 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 18/264 (6%)

Query: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777
            + DL IT  I LN + MA+EHY      +E L++ N +FT IF  E  FK++A     +F
Sbjct: 1578 YLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFF 1637

Query: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827
            Q  WN  D  IV+LS+M + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 1638 QDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1697

Query: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887
            L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +      GL       +F  A
Sbjct: 1698 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMA 1757

Query: 888  FLIIFRILCGE-WIETMWDCM-EVSGQSLCL------LVFLLVMVIGNLVVLNLFLALLL 939
            FL +FR+  G+ W   M D + +   +S C       + F+  ++    V++N+ +A+L+
Sbjct: 1758 FLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 940  SSFSADNLTAPDEDREMNNLQLAL 963
                  N  A +E      L+L +
Sbjct: 1818 KHLEESNKEAKEEAELEAELELEM 1841



 Score =  102 bits (254), Expect = 4e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 77/318 (24%), Positives = 145/318 (45%), Gaps = 52/318 (16%)

Query: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756

Query: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814

Query: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869

Query: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904

Query: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGN 952

Query: 1459 FFTLNLFIGVIIDNFNQQ 1476
            +   NL + ++++ F  +
Sbjct: 953  YVLFNLLVAILVEGFQAE 970



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVLY--------------------NGMASTSSWAALYFIALMTF 950

Query: 1759 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1791
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197

Query: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,337,637
Number of Sequences: 37866
Number of extensions: 3715804
Number of successful extensions: 25227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 324
Number of HSP's that attempted gapping in prelim test: 18923
Number of HSP's gapped (non-prelim): 3471
length of query: 2016
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1899
effective length of database: 13,817,196
effective search space: 26238855204
effective search space used: 26238855204
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.