Search of human proteins with 37622899

Search of human proteins with 37622899

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37622899 ring finger protein 137 [Homo sapiens]
         (485 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37622899 ring finger protein 137 [Homo sapiens]                   1017   0.0  
gi|15208660 tripartite motif protein 21 [Homo sapiens]                377   e-104
gi|112421127 tripartite motif-containing 58 [Homo sapiens]            373   e-103
gi|21630277 tripartite motif-containing 11 [Homo sapiens]             368   e-102
gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]    342   3e-94
gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]    342   3e-94
gi|5730009 ret finger protein [Homo sapiens]                          327   2e-89
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]   326   3e-89
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]   314   1e-85
gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]      296   2e-80
gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]      296   2e-80
gi|51477690 tripartite motif-containing 6 and tripartite motif-c...   296   2e-80
gi|5454014 tripartite motif-containing 38 [Homo sapiens]              294   1e-79
gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo s...   292   4e-79
gi|117938316 tripartite motif-containing 22 [Homo sapiens]            287   2e-77
gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]   286   2e-77
gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]    286   2e-77
gi|157426898 tripartite motif-containing 10 isoform 1 [Homo sapi...   278   8e-75
gi|157743261 tripartite motif-containing 75 [Homo sapiens]            270   2e-72
gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]   268   1e-71
gi|31542779 tripartite motif family-like 1 [Homo sapiens]             262   5e-70
gi|22749269 ring finger protein 129 [Homo sapiens]                    245   7e-65
gi|157426896 tripartite motif-containing 10 isoform 2 [Homo sapi...   244   2e-64
gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo sa...   243   2e-64
gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]    243   2e-64
gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo s...   232   7e-61
gi|4557743 Mediterranean fever protein [Homo sapiens]                 230   2e-60
gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]   226   3e-59
gi|169202375 PREDICTED: tripartite motif-containing protein 64B-...   215   8e-56
gi|210147600 tripartite motif-containing 64 [Homo sapiens]            210   2e-54

>gi|37622899 ring finger protein 137 [Homo sapiens]
          Length = 485

 Score = 1017 bits (2629), Expect = 0.0
 Identities = 485/485 (100%), Positives = 485/485 (100%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60
           MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC
Sbjct: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60

Query: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEAC 120
           RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEAC
Sbjct: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEAC 120

Query: 121 SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR 180
           SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR
Sbjct: 121 SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR 180

Query: 181 KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV 240
           KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV
Sbjct: 181 KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV 240

Query: 241 LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKT 300
           LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKT
Sbjct: 241 LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKT 300

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
           YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW
Sbjct: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360

Query: 361 EVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPP 420
           EVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPP
Sbjct: 361 EVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPP 420

Query: 421 RRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICS 480
           RRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICS
Sbjct: 421 RRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICS 480

Query: 481 LDGED 485
           LDGED
Sbjct: 481 LDGED 485


>gi|15208660 tripartite motif protein 21 [Homo sapiens]
          Length = 475

 Score =  377 bits (968), Expect = e-104
 Identities = 207/482 (42%), Positives = 292/482 (60%), Gaps = 16/482 (3%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60
           M   A +  + EEV CPIC+    EP+SI+CGHSFC  C+S +       +  G  CP+C
Sbjct: 1   MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV------GKGGGSVCPVC 54

Query: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEAC 120
           R     +NLRPN QLAN+V  ++ +      G +G+ C  HGE+L +FC++D   +C  C
Sbjct: 55  RQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVC 114

Query: 121 SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR 180
           +QS +H  H++VP+E+ A EY+ +L  AL  L+++QE A KLEV    + A WK  VET+
Sbjct: 115 AQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQ 174

Query: 181 KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV 240
           K  I  EF + +  L +++   RQL          L+++  E ++ L    ++L QQSQ 
Sbjct: 175 KSRIHAEFVQQKNFLVEEE--QRQL--------QELEKDEREQLRILGEKEAKLAQQSQA 224

Query: 241 LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKT 300
           L  +I+EL  R       +LQ++  VL RS+SW+L+  +  S EL++ C V GL+++L+T
Sbjct: 225 LQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRT 284

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
            A  + LDPDTA   LI+SEDR++V  GDT Q +P N ERF  Y +VLG+Q   SG+HYW
Sbjct: 285 CAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYW 344

Query: 361 EVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPP 420
           EV+V  +  W LGVC+ +V RK    LS   GFW I L    +Y AGT     L L VPP
Sbjct: 345 EVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP 404

Query: 421 RRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICS 480
            +VGIF+DYEA  +SFYN+TD GS I++F    F G L P+FSP ++ G  NTAPL +C 
Sbjct: 405 CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP 464

Query: 481 LD 482
           L+
Sbjct: 465 LN 466


>gi|112421127 tripartite motif-containing 58 [Homo sapiens]
          Length = 486

 Score =  373 bits (958), Expect = e-103
 Identities = 202/459 (44%), Positives = 279/459 (60%), Gaps = 16/459 (3%)

Query: 8   EAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPR 67
           E + E+  CP+C+ FL+EP+S+DCGHSFC  C+S   E    +Q   Y CP CR P +P 
Sbjct: 8   ERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCRGPFRPS 67

Query: 68  NLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHE 127
             RPN QLA +VE VR L L  G G +   C RHGE L  FC+ED   +C  C   PEH 
Sbjct: 68  GFRPNRQLAGLVESVRRLGLGAGPGARR--CARHGEDLSRFCEEDEAALCWVCDAGPEHR 125

Query: 128 AHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWE 187
            H   P+++ A  Y+ +L  ALE ++KE E+A   E    K+T  WK +VE ++Q    E
Sbjct: 126 THRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLE 185

Query: 188 FEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAE 247
           FEK++  L +++   RQL          L+ E   T+Q+L  + S L+QQS+ L  +  E
Sbjct: 186 FEKHRGFLAQEE--QRQL--------RRLEAEERATLQRLRESKSRLVQQSKALKELADE 235

Query: 248 LKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRL 307
           L+ER QRP   +L+ ++ VL+RSK+ +  + E I +ELKT C + G RE+L+ +  DV+L
Sbjct: 236 LQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKL 295

Query: 308 DPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDR 367
           DP TA+  L+++ D + V  G+  + +P+NPERF  +  +LG Q  SSGRHYWEV VG+ 
Sbjct: 296 DPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEG 355

Query: 368 SEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRA-GTDEYPILSLPVPPRRVGIF 426
           +EWGLGVC+  + RK     SP  G W + L KGNEY    +   P+L L   PR +GIF
Sbjct: 356 AEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLE-SPRCIGIF 414

Query: 427 VDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPC 465
           +DYEA +ISFYNVTD GS+I+TF +  F G L PYF  C
Sbjct: 415 LDYEAGEISFYNVTD-GSYIYTFNQL-FSGLLRPYFFIC 451


>gi|21630277 tripartite motif-containing 11 [Homo sapiens]
          Length = 468

 Score =  368 bits (944), Expect = e-102
 Identities = 205/472 (43%), Positives = 280/472 (59%), Gaps = 24/472 (5%)

Query: 12  EEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNLRP 71
           EE  C IC+ +  +P+  DCGH+FC  C+   W  P       Y CP CR     RNLRP
Sbjct: 12  EEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQP----EGPYACPECRELSPQRNLRP 67

Query: 72  NWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSV 131
           N  LA + E  R  RLHP   +   +C  H E L  FC +++ ++C AC +S EH AH V
Sbjct: 68  NRPLAKMAEMAR--RLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEHWAHRV 125

Query: 132 VPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKY 191
            P++D A + K +L ++LEHL+K+ ++A   +    +    W+  VE+++Q+++ EFE+ 
Sbjct: 126 RPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERL 185

Query: 192 QRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELKER 251
           +RLL +++   +QL       L  L+ E  E + +L    + L QQS  L  +IAEL+ R
Sbjct: 186 RRLLAEEE---QQL-------LQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGR 235

Query: 252 SQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDT 311
            Q P   +LQDI++ L R +   LQ PE + +EL+T CRV GL E L+ +  DV LDPDT
Sbjct: 236 CQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDT 295

Query: 312 AYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWG 371
           A   LI+SEDR+ V  GD  Q LPD+PERF     VLG +  +SGRHYWEVEVGDR+ W 
Sbjct: 296 ANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWA 355

Query: 372 LGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEA 431
           LGVC++NV+RKE   LS   GFW++ +  G+ Y   + E  +  L  PPRRVGIF+DYEA
Sbjct: 356 LGVCRENVNRKEKGELSAGNGFWIL-VFLGSYY--NSSERALAPLRDPPRRVGIFLDYEA 412

Query: 432 HDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDG 483
             +SFY+ TD GS +F FP  PF G L P FSP  S  T    P+ IC   G
Sbjct: 413 GHLSFYSATD-GSLLFIFPEIPFSGTLRPLFSPLSSSPT----PMTICRPKG 459


>gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]
          Length = 488

 Score =  342 bits (878), Expect = 3e-94
 Identities = 185/478 (38%), Positives = 281/478 (58%), Gaps = 33/478 (6%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNL 69
           I EEV CPIC+  L EP+SIDCGHSFC +C++         Q    +CP+C+   QP NL
Sbjct: 9   IREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNL 68

Query: 70  RPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAH 129
           RPN  LAN+V ++R + L PG  LK  LC  HGEKL++FC+ED  ++C  C +S EH  H
Sbjct: 69  RPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGH 128

Query: 130 SVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFE 189
               +E+VA EY+ +  E+L+ LK E++EA KL    R++  +WK Q+E  +  I  EF 
Sbjct: 129 HTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFN 188

Query: 190 KYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249
           + + +L++ +             L  L++E  + ++ +E   ++L+ Q+Q L  +I++L+
Sbjct: 189 QLRNILDRVE----------QRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLE 238

Query: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILK---------T 300
            R Q     +LQD+ +V  RS+ W+L++PE +  +L++  R   L+ +L+         +
Sbjct: 239 RRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQS 298

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
           Y  DV L+P TA   L+++++R++V +       P   E+ Y  + VLGSQ  SSG+HYW
Sbjct: 299 YWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCS-VLGSQHFSSGKHYW 357

Query: 361 EVEVGDRSEWGLGVCKQNV-----------DRKEVVYLSPHYGFWVIRLRKGNEYRAGTD 409
           EV+V  ++ W LGVC  ++           +        P  G+WVI L+  +EYRA  D
Sbjct: 358 EVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYED 417

Query: 410 EYP--ILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPC 465
             P  +LS+ VPPRRVG+F+DYEA  +SFYNVT+ G  I+TF +Y FP  L PYF+PC
Sbjct: 418 SSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPC 475


>gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]
          Length = 516

 Score =  342 bits (878), Expect = 3e-94
 Identities = 185/478 (38%), Positives = 281/478 (58%), Gaps = 33/478 (6%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNL 69
           I EEV CPIC+  L EP+SIDCGHSFC +C++         Q    +CP+C+   QP NL
Sbjct: 37  IREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNL 96

Query: 70  RPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAH 129
           RPN  LAN+V ++R + L PG  LK  LC  HGEKL++FC+ED  ++C  C +S EH  H
Sbjct: 97  RPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGH 156

Query: 130 SVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFE 189
               +E+VA EY+ +  E+L+ LK E++EA KL    R++  +WK Q+E  +  I  EF 
Sbjct: 157 HTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFN 216

Query: 190 KYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249
           + + +L++ +             L  L++E  + ++ +E   ++L+ Q+Q L  +I++L+
Sbjct: 217 QLRNILDRVE----------QRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLE 266

Query: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILK---------T 300
            R Q     +LQD+ +V  RS+ W+L++PE +  +L++  R   L+ +L+         +
Sbjct: 267 RRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQS 326

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
           Y  DV L+P TA   L+++++R++V +       P   E+ Y  + VLGSQ  SSG+HYW
Sbjct: 327 YWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCS-VLGSQHFSSGKHYW 385

Query: 361 EVEVGDRSEWGLGVCKQNV-----------DRKEVVYLSPHYGFWVIRLRKGNEYRAGTD 409
           EV+V  ++ W LGVC  ++           +        P  G+WVI L+  +EYRA  D
Sbjct: 386 EVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYED 445

Query: 410 EYP--ILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPC 465
             P  +LS+ VPPRRVG+F+DYEA  +SFYNVT+ G  I+TF +Y FP  L PYF+PC
Sbjct: 446 SSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPC 503


>gi|5730009 ret finger protein [Homo sapiens]
          Length = 513

 Score =  327 bits (837), Expect = 2e-89
 Identities = 194/510 (38%), Positives = 282/510 (55%), Gaps = 47/510 (9%)

Query: 5   ALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPV 64
           ++ E + +E  CP+C+ +  EPM +DCGH+ C +CL+  W   G ++    +CP CR   
Sbjct: 5   SVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCW---GTAET-NVSCPQCRETF 60

Query: 65  QPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDL--CERHGEKLKMFCKEDVLIMCEACSQ 122
             R++RPN  LANV + V+ LR     G  G++  CE+H E LK++C+ED + +C  C +
Sbjct: 61  PQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDR 120

Query: 123 SPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQE-EAWKLEVGERKRTATWKIQVETRK 181
           S EH  HSV+P+E+    +K ++   L+HLK+ ++ +  +   GE+ R     +  +  +
Sbjct: 121 SREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSL-TQMER 179

Query: 182 QSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQR-EAAETMQKLELNHSELIQQSQV 240
           + IVWEFE+    L  K+  +R L       LA       A T     ++H         
Sbjct: 180 EKIVWEFEQLYHSL--KEHEYRLLARLEELDLAIYNSINGAITQFSCNISH--------- 228

Query: 241 LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQP--EPISLELKTDC---RVLGLR 295
           L  +IA+L+E+ Q+P R +LQDI + L+R++   + +P   P  L+ K      + L L 
Sbjct: 229 LSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLT 288

Query: 296 EILKT--------------------YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLP 335
           E LK                     Y+ DV LDPDTAY  LI+S++ ++V Y    Q LP
Sbjct: 289 ESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLP 348

Query: 336 DNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWV 395
           DNPERF  +  VLGS C  +GRHYWEVEVGD+++W +GVC+ +V RK  V  +P  GFW 
Sbjct: 349 DNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWA 408

Query: 396 IRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFP 455
           + L  G EY A T     L L  P +RVGIF+DY+A ++SFYNVT+   H FTF    F 
Sbjct: 409 VSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTE-RCHTFTFSHATFC 467

Query: 456 GRLLPYFSPCYSIGTNNTAPLAICSLDGED 485
           G + PYFS  YS G  + APL IC + G D
Sbjct: 468 GPVRPYFSLSYS-GGKSAAPLIICPMSGID 496


>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
          Length = 488

 Score =  326 bits (836), Expect = 3e-89
 Identities = 183/480 (38%), Positives = 277/480 (57%), Gaps = 22/480 (4%)

Query: 5   ALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPV 64
           A +E +  E +C +C+ +L+EP+ I+CGH+FC +C++  WE         + CP+CR   
Sbjct: 18  AALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCRKTS 73

Query: 65  QPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSP 124
           + R+LRPN QL ++VE  + L+          LC +H E L +FC ED   +C  C+ S 
Sbjct: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133

Query: 125 EHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSI 184
            H AH+VVP++D   EYK +L + LE L+++ +E  + +  E K+    K  VE+R+Q I
Sbjct: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193

Query: 185 VWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRM 244
           + EFE+           HR+L  E    L+ L+ E  + +Q+L  N + L  + + L  +
Sbjct: 194 LREFEEL----------HRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHL 243

Query: 245 IAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDC-----RVLGLREILK 299
            AE++ +  +    ML+D++  L + +     +   +S+EL+ +      +   LR+ILK
Sbjct: 244 AAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILK 303

Query: 300 TYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQK-LPDNPERFYRYNIVLGSQCISSGRH 358
              ADV LDP+TA+  L++SEDRK V + +T  + LPD P RF  Y  VL ++  +SGRH
Sbjct: 304 QLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRH 363

Query: 359 YWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPV 418
           YWEVEVGD++ W +GVC+ +V RK  +   P  G+W +RL  G++Y A T  +  L + V
Sbjct: 364 YWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKV 423

Query: 419 PPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAI 478
            P+RVGIF+DYEA  +SFYNVTD  SHI+TF    F  +L P F P    G  N APL I
Sbjct: 424 KPKRVGIFLDYEAGTLSFYNVTD-RSHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAPLTI 481


>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
          Length = 518

 Score =  314 bits (804), Expect = 1e-85
 Identities = 185/510 (36%), Positives = 278/510 (54%), Gaps = 52/510 (10%)

Query: 5   ALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPV 64
           A +E +  E +C +C+ +L+EP+ I+CGH+FC +C++  WE         + CP+CR   
Sbjct: 18  AALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWE----DLERDFPCPVCRKTS 73

Query: 65  QPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSP 124
           + R+LRPN QL ++VE  + L+          LC +H E L +FC ED   +C  C+ S 
Sbjct: 74  RYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISH 133

Query: 125 EHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSI 184
            H AH+VVP++D   EYK +L + LE L+++ +E  + +  E K+    K  VE+R+Q I
Sbjct: 134 THRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQI 193

Query: 185 VWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRM 244
           + EFE+           HR+L  E    L+ L+ E  + +Q+L  N + L  + + L  +
Sbjct: 194 LREFEEL----------HRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHL 243

Query: 245 IAELKERSQRPVRWMLQDIQEVL------------------------------NRSKSWS 274
            AE++ +  +    ML+D++  L                              NR +   
Sbjct: 244 AAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVK 303

Query: 275 LQQPEPISLELKTDC-----RVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGD 329
             +   +S+EL+ +      +   LR+ILK   ADV LDP+TA+  L++SEDRK V + +
Sbjct: 304 TMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVE 363

Query: 330 TNQK-LPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLS 388
           T  + LPD P RF  Y  VL ++  +SGRHYWEVEVGD++ W +GVC+ +V RK  +   
Sbjct: 364 TRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPL 423

Query: 389 PHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFT 448
           P  G+W +RL  G++Y A T  +  L + V P+RVGIF+DYEA  +SFYNVTD  SHI+T
Sbjct: 424 PETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTD-RSHIYT 482

Query: 449 FPRYPFPGRLLPYFSPCYSIGTNNTAPLAI 478
           F    F  +L P F P    G  N APL I
Sbjct: 483 FTD-TFTEKLWPLFYPGIRAGRKNAAPLTI 511


>gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  296 bits (759), Expect = 2e-80
 Identities = 179/498 (35%), Positives = 270/498 (54%), Gaps = 50/498 (10%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNL 69
           + EEV CPIC+  L EP+S+DCGHS C +C++   +    S     +CP+C       +L
Sbjct: 9   VQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSFEHL 68

Query: 70  RPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAH 129
           + N  LAN+VE+++ ++L P  G K DLC+ HGEKL +FCKED  ++C  C +S EH  H
Sbjct: 69  QANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEHRGH 128

Query: 130 SVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFE 189
             V  E+V  E + +L   L+ LKKE+EEA KLE   R+   +WK QV+T +Q I  EF+
Sbjct: 129 HTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFD 188

Query: 190 KYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249
           + + +L            E    L  L+ E  +T+ K      EL+QQ Q++  +I++++
Sbjct: 189 QLRSILNN----------EEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVE 238

Query: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREIL---------KT 300
            RSQ     +LQD+  ++  S+ W L++P+ +S +LKT      L  +L         + 
Sbjct: 239 CRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRC 298

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
           Y  DV L+       L++SED+++V        +P  P + Y Y  VLGSQ  SSG+HYW
Sbjct: 299 YWVDVTLNSVNLNLNLVLSEDQRQV------ISVPIWPFQCYNYG-VLGSQYFSSGKHYW 351

Query: 361 EVEVGDRSEWGLGVCKQNVDR-----------KEVVYLS--PHYGFWVIRLRKGNEY--- 404
           EV+V  ++ W LGV  +   R           ++ +Y    P +G+WVI L+   +Y   
Sbjct: 352 EVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVF 411

Query: 405 ---RAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPY 461
               +   E   LS+ VPP RVG+F+DYEA  +SF+NVT  GS I+ F +  F   + PY
Sbjct: 412 EESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPY 471

Query: 462 FSPCYSIGTNNTAPLAIC 479
           F+P      N  AP+ +C
Sbjct: 472 FNP-----WNCPAPMTLC 484


>gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  296 bits (759), Expect = 2e-80
 Identities = 179/498 (35%), Positives = 270/498 (54%), Gaps = 50/498 (10%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNL 69
           + EEV CPIC+  L EP+S+DCGHS C +C++   +    S     +CP+C       +L
Sbjct: 9   VQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSFEHL 68

Query: 70  RPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAH 129
           + N  LAN+VE+++ ++L P  G K DLC+ HGEKL +FCKED  ++C  C +S EH  H
Sbjct: 69  QANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEHRGH 128

Query: 130 SVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFE 189
             V  E+V  E + +L   L+ LKKE+EEA KLE   R+   +WK QV+T +Q I  EF+
Sbjct: 129 HTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFD 188

Query: 190 KYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249
           + + +L            E    L  L+ E  +T+ K      EL+QQ Q++  +I++++
Sbjct: 189 QLRSILNN----------EEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVE 238

Query: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREIL---------KT 300
            RSQ     +LQD+  ++  S+ W L++P+ +S +LKT      L  +L         + 
Sbjct: 239 CRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRC 298

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
           Y  DV L+       L++SED+++V        +P  P + Y Y  VLGSQ  SSG+HYW
Sbjct: 299 YWVDVTLNSVNLNLNLVLSEDQRQV------ISVPIWPFQCYNYG-VLGSQYFSSGKHYW 351

Query: 361 EVEVGDRSEWGLGVCKQNVDR-----------KEVVYLS--PHYGFWVIRLRKGNEY--- 404
           EV+V  ++ W LGV  +   R           ++ +Y    P +G+WVI L+   +Y   
Sbjct: 352 EVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVF 411

Query: 405 ---RAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPY 461
               +   E   LS+ VPP RVG+F+DYEA  +SF+NVT  GS I+ F +  F   + PY
Sbjct: 412 EESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPY 471

Query: 462 FSPCYSIGTNNTAPLAIC 479
           F+P      N  AP+ +C
Sbjct: 472 FNP-----WNCPAPMTLC 484


>gi|51477690 tripartite motif-containing 6 and tripartite
           motif-containing 34 [Homo sapiens]
          Length = 842

 Score =  296 bits (759), Expect = 2e-80
 Identities = 179/498 (35%), Positives = 270/498 (54%), Gaps = 50/498 (10%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNL 69
           + EEV CPIC+  L EP+S+DCGHS C +C++   +    S     +CP+C       +L
Sbjct: 363 VQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSFEHL 422

Query: 70  RPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAH 129
           + N  LAN+VE+++ ++L P  G K DLC+ HGEKL +FCKED  ++C  C +S EH  H
Sbjct: 423 QANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEHRGH 482

Query: 130 SVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFE 189
             V  E+V  E + +L   L+ LKKE+EEA KLE   R+   +WK QV+T +Q I  EF+
Sbjct: 483 HTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFD 542

Query: 190 KYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249
           + + +L            E    L  L+ E  +T+ K      EL+QQ Q++  +I++++
Sbjct: 543 QLRSILNN----------EEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVE 592

Query: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREIL---------KT 300
            RSQ     +LQD+  ++  S+ W L++P+ +S +LKT      L  +L         + 
Sbjct: 593 CRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRC 652

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
           Y  DV L+       L++SED+++V        +P  P + Y Y  VLGSQ  SSG+HYW
Sbjct: 653 YWVDVTLNSVNLNLNLVLSEDQRQV------ISVPIWPFQCYNYG-VLGSQYFSSGKHYW 705

Query: 361 EVEVGDRSEWGLGVCKQNVDR-----------KEVVYLS--PHYGFWVIRLRKGNEY--- 404
           EV+V  ++ W LGV  +   R           ++ +Y    P +G+WVI L+   +Y   
Sbjct: 706 EVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVF 765

Query: 405 ---RAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPY 461
               +   E   LS+ VPP RVG+F+DYEA  +SF+NVT  GS I+ F +  F   + PY
Sbjct: 766 EESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPY 825

Query: 462 FSPCYSIGTNNTAPLAIC 479
           F+P      N  AP+ +C
Sbjct: 826 FNP-----WNCPAPMTLC 838



 Score =  210 bits (534), Expect = 3e-54
 Identities = 108/290 (37%), Positives = 173/290 (59%), Gaps = 10/290 (3%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNL 69
           I EEV CPIC+  L EP+SIDCGHSFC +C++         Q    +CP+C+   QP NL
Sbjct: 37  IREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNL 96

Query: 70  RPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAH 129
           RPN  LAN+V ++R + L PG  LK  LC  HGEKL++FC+ED  ++C  C +S EH  H
Sbjct: 97  RPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGH 156

Query: 130 SVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFE 189
               +E+VA EY+ +  E+L+ LK E++EA KL    R++  +WK Q+E  +  I  EF 
Sbjct: 157 HTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFN 216

Query: 190 KYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249
           + + +L++ +             L  L++E  + ++ +E   ++L+ Q+Q L  +I++L+
Sbjct: 217 QLRNILDRVE----------QRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLE 266

Query: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILK 299
            R Q     +LQD+ +V  RS+ W+L++PE +  +L++  R   L+ +L+
Sbjct: 267 RRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLR 316


>gi|5454014 tripartite motif-containing 38 [Homo sapiens]
          Length = 465

 Score =  294 bits (753), Expect = 1e-79
 Identities = 165/468 (35%), Positives = 262/468 (55%), Gaps = 24/468 (5%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQ--NWGYTCP 58
           M  T   + ++EE  C IC++ +  P+SI+CGHS+CH C++  ++ P + Q     + CP
Sbjct: 1   MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCP 60

Query: 59  LCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCE 118
            CRAP    +LRPN QL +++E ++              CE HGE+  +FC+++  ++C 
Sbjct: 61  QCRAPFHMDSLRPNKQLGSLIEALKETDQEMS-------CEEHGEQFHLFCEDEGQLICW 113

Query: 119 ACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVE 178
            C ++P+H+ H+   +EDV   YK +L +A+  LK+ ++   + ++    R   WK +V+
Sbjct: 114 RCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQ 173

Query: 179 TRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQS 238
            ++Q I  +F+  Q  L +++  +          L  L++E  +T+ +L    + L  +S
Sbjct: 174 IQRQKIRSDFKNLQCFLHEEEKSY----------LWRLEKEEQQTLSRLRDYEAGLGLKS 223

Query: 239 QVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGL---- 294
             L   I EL+E+ Q   + +LQ++ + L+RS +  L+  E +SLEL T C V  L    
Sbjct: 224 NELKSHILELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDV 283

Query: 295 REILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCIS 354
           +++L+++   V LDPDTA+  LI+SEDR++V  G T +    +  RF  +  VLG +  +
Sbjct: 284 KKMLRSHQVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFT 343

Query: 355 SGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPIL 414
           SGR Y+EV+VG+ + W LGVC +NV R   +   P  GFW +RL K   Y A T     L
Sbjct: 344 SGRRYFEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSL 403

Query: 415 SLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYF 462
            L   P  VGIF+DYEA  +SFYN  + G HIFTFP+  F   L PYF
Sbjct: 404 HLHEQPLLVGIFLDYEAGVVSFYN-GNTGCHIFTFPKASFSDTLRPYF 450


>gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo
           sapiens]
          Length = 493

 Score =  292 bits (748), Expect = 4e-79
 Identities = 179/510 (35%), Positives = 284/510 (55%), Gaps = 67/510 (13%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIP----GESQNWGYTCPLCRAPVQ 65
           + EEV CPIC+  L +P+S+DCGHSFC +CL+   +      GES     +CP+CR   Q
Sbjct: 9   VKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGES-----SCPVCRISYQ 63

Query: 66  PRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPE 125
           P N+RPN  +AN+VEK+R ++L P  G K D C RHGEKL +FC+ED  ++C  C +S E
Sbjct: 64  PENIRPNRHVANLVEKLREVKLSPE-GQKVDHCARHGEKLLLFCQEDGKVICWLCERSQE 122

Query: 126 HEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIV 185
           H  H   P E+VA EY+ +L  ALE L+++Q+EA +LE   R+  A+WK Q++  K +++
Sbjct: 123 HRGHHTFPTEEVAQEYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVL 182

Query: 186 WEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMI 245
            +FE+ + +L+           E +  L +L++E  + ++ L  + +E++QQ+Q L  +I
Sbjct: 183 ADFEQLRDILD----------WEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELI 232

Query: 246 AELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREIL------- 298
           ++L+ R Q  V  +LQ +  V+ R+++ +L++PE      +   R   L+ +L       
Sbjct: 233 SDLEHRLQGSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGMLEVFRELT 292

Query: 299 --KTYAADVRLDPDTAYSRLIVSEDRKRVH-------YGDTNQKLPDNPERFYRYNI--- 346
             + Y  DV + P+   S  ++SED+++V        YG    +     + F  +N    
Sbjct: 293 DVRRYWVDVTVAPNN-ISCAVISEDKRQVSSPKPQIIYGARGTRY----QTFVNFNYCTG 347

Query: 347 VLGSQCISSGRHYWEVEVGDRSEWGLGVCKQ-------NVDRKEVVYLSPHYGFWVIRLR 399
           +LGSQ I+SG+HYWEV+V  ++ W LGVC         N+++ E     P YG+WVI L 
Sbjct: 348 ILGSQSITSGKHYWEVDVSKKTAWILGVCAGFQPDAMCNIEKNE--NYQPKYGYWVIGLE 405

Query: 400 KGNEYRA------GTDEYPI---LSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFP 450
           +G +  A       T   P    LS+ + P RVG+F+DYEA  +SF+N+T+ G  I+ F 
Sbjct: 406 EGVKCSAFQDSSFHTPSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFS 465

Query: 451 RYPFPGRLLPYFSPCYSIGTNNTAPLAICS 480
              F   + PY +P          P+ +CS
Sbjct: 466 HCSFSQPVFPYLNP-----RKCGVPMTLCS 490


>gi|117938316 tripartite motif-containing 22 [Homo sapiens]
          Length = 498

 Score =  287 bits (734), Expect = 2e-77
 Identities = 175/502 (34%), Positives = 268/502 (53%), Gaps = 48/502 (9%)

Query: 10  IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNL 69
           I +EV CPIC+  L EP+S+DCGHSFC +C++   +          +CP+C+   QP NL
Sbjct: 9   IEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNL 68

Query: 70  RPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAH 129
           RPN  LAN+VE+V+ +++ P  G K D+CE HG+KL++FCKED  ++C  C  S EH+ H
Sbjct: 69  RPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGH 128

Query: 130 SVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFE 189
               + +V  E + +L  AL+ L KE +EA KLE   R+    WK  ++  +Q I+  F 
Sbjct: 129 QTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFN 188

Query: 190 KYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249
           + + +L+           E    L  L+      +  L     +L+QQ Q    +I++L+
Sbjct: 189 EMRVILDN----------EEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQ 238

Query: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRV---LGLREILKT------ 300
            R +     MLQD+ +V+ RS+SW+L++P+ +S +LK+  RV    G+ ++LK       
Sbjct: 239 RRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQY 298

Query: 301 YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW 360
           Y  DV L+P +A S + +S D+++V    T      NP  F  +  V G Q  SSG++YW
Sbjct: 299 YWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFG-VFGCQYFSSGKYYW 357

Query: 361 EVEVGDRSEWGLGVCKQ----------------NVDRKEVV-YLSPHYGFWVIRLRKGNE 403
           EV+V  +  W LGV  +                +V+  +V     P YG+WVI L+   E
Sbjct: 358 EVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCE 417

Query: 404 YRAGTD------EYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGR 457
           Y A  D      +   L + VPP R+G+F+DYEA  +SF+NVT+ G+ I+ F    F   
Sbjct: 418 YNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRP 477

Query: 458 LLPYFSPCYSIGTNNTAPLAIC 479
             PYF+P      N   P+ +C
Sbjct: 478 AYPYFNP-----WNCLVPMTVC 494


>gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  286 bits (733), Expect = 2e-77
 Identities = 170/471 (36%), Positives = 256/471 (54%), Gaps = 24/471 (5%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIP----GESQNWG-Y 55
           M+   L   + EE  C IC+ +  +P+   CGH+FC +C+   WE      G  +  G +
Sbjct: 1   MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 60

Query: 56  TCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLI 115
            CP CR     RNL PN  L  V E   + + HPG+  K DLC+ H E LK+FC++D   
Sbjct: 61  PCPECREMSPQRNLLPNRLLTKVAE---MAQQHPGLQ-KQDLCQEHHEPLKLFCQKDQSP 116

Query: 116 MCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKI 175
           +C  C +S EH  H V+P E+    YK +L E +E+L+++      L+  E +  A W+ 
Sbjct: 117 ICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQG 176

Query: 176 QVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELI 235
           +V+ R++ IV EFEK    L +          E    L +L+ E  ET  +L  + + L 
Sbjct: 177 KVKERRERIVLEFEKMNLYLVE----------EEQRLLQALETEEEETASRLRESVACLD 226

Query: 236 QQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPI-SLELKTDCRVLGL 294
           +Q   L  ++ +L+ERS +    MLQD++E L+R  + S+Q PE       +T CRV G 
Sbjct: 227 RQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQ 286

Query: 295 REILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLP-DNPERFYRYNIVLGSQCI 353
            E+L+ +  DV  D  +AY  L++ E R+R + G + +     + +RF  Y   +G    
Sbjct: 287 IEVLRGFLEDVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAF 346

Query: 354 SSGRHYWEVEVGDRSE--WGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEY 411
           SSGRHYWEV +    +  W LGVC+ NV RK+ V   P  GFWV++L KG +Y +     
Sbjct: 347 SSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSAL 406

Query: 412 PILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYF 462
             + L  PP  +GIF+D+EA ++SFY+V+D GSH+ T+ +  FPG L P+F
Sbjct: 407 TPVMLMEPPSHMGIFLDFEAGEVSFYSVSD-GSHLHTYSQATFPGPLQPFF 456


>gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  286 bits (733), Expect = 2e-77
 Identities = 170/471 (36%), Positives = 256/471 (54%), Gaps = 24/471 (5%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIP----GESQNWG-Y 55
           M+   L   + EE  C IC+ +  +P+   CGH+FC +C+   WE      G  +  G +
Sbjct: 1   MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 60

Query: 56  TCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLI 115
            CP CR     RNL PN  L  V E   + + HPG+  K DLC+ H E LK+FC++D   
Sbjct: 61  PCPECREMSPQRNLLPNRLLTKVAE---MAQQHPGLQ-KQDLCQEHHEPLKLFCQKDQSP 116

Query: 116 MCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKI 175
           +C  C +S EH  H V+P E+    YK +L E +E+L+++      L+  E +  A W+ 
Sbjct: 117 ICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQG 176

Query: 176 QVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELI 235
           +V+ R++ IV EFEK    L +          E    L +L+ E  ET  +L  + + L 
Sbjct: 177 KVKERRERIVLEFEKMNLYLVE----------EEQRLLQALETEEEETASRLRESVACLD 226

Query: 236 QQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPI-SLELKTDCRVLGL 294
           +Q   L  ++ +L+ERS +    MLQD++E L+R  + S+Q PE       +T CRV G 
Sbjct: 227 RQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQ 286

Query: 295 REILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLP-DNPERFYRYNIVLGSQCI 353
            E+L+ +  DV  D  +AY  L++ E R+R + G + +     + +RF  Y   +G    
Sbjct: 287 IEVLRGFLEDVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAF 346

Query: 354 SSGRHYWEVEVGDRSE--WGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEY 411
           SSGRHYWEV +    +  W LGVC+ NV RK+ V   P  GFWV++L KG +Y +     
Sbjct: 347 SSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSAL 406

Query: 412 PILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYF 462
             + L  PP  +GIF+D+EA ++SFY+V+D GSH+ T+ +  FPG L P+F
Sbjct: 407 TPVMLMEPPSHMGIFLDFEAGEVSFYSVSD-GSHLHTYSQATFPGPLQPFF 456


>gi|157426898 tripartite motif-containing 10 isoform 1 [Homo
           sapiens]
          Length = 481

 Score =  278 bits (711), Expect = 8e-75
 Identities = 166/485 (34%), Positives = 269/485 (55%), Gaps = 40/485 (8%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60
           M   A V ++ +EV CPIC   LREP++IDCGH+FC +CL+   EIPG       TCPLC
Sbjct: 1   MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC 60

Query: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGL-KGDLCERHGEKLKMFCKEDVLIMCEA 119
           + P +P + RPNWQLANVVE +  L+L   +GL + D+C+ HGEK+  FC++D + +C  
Sbjct: 61  KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVV 120

Query: 120 CSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVET 179
           C ++ EH  H++  +ED A  Y+ ++H+ L+ L+KE+EE  +++  E KR      QV T
Sbjct: 121 CREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVST 180

Query: 180 RKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQ 239
           ++Q ++ EF   ++ LE++Q          +  LA L+ +  + ++  + +  +L+   +
Sbjct: 181 KRQQVISEFAHLRKFLEEQQ----------SILLAQLESQDGDILR--QRDEFDLLVAGE 228

Query: 240 V--LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCR-----VL 292
           +     +I EL+E+++RP R +L DI+  L R ++   ++P  +S EL    R      L
Sbjct: 229 ICRFSALIEELEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQAL 288

Query: 293 GLREILKTY-----------AADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERF 341
            L+  +K +            A + LDP T++ +L++SED +R  +    Q  PDNP+RF
Sbjct: 289 PLQREMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRF 348

Query: 342 YRYNIVLGSQCISSGRHYWEVEVGDRSEWG---LGVCKQNVDRKEVVYLSPHYGFWVIRL 398
            R   VL    I+ GRH W V + D +  G   +GV  ++V RK  + L P  G W +RL
Sbjct: 349 DRATCVLAHTGITGGRHTWVVSI-DLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRL 407

Query: 399 RKGNEYRAGTDEYPI-LSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGR 457
             G  + +    +P  L+L   PR+V + +DYE   ++F N       I+TF    F  +
Sbjct: 408 AWG--FVSALGSFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAV-TREPIYTFTA-SFTRK 463

Query: 458 LLPYF 462
           ++P+F
Sbjct: 464 VIPFF 468


>gi|157743261 tripartite motif-containing 75 [Homo sapiens]
          Length = 468

 Score =  270 bits (691), Expect = 2e-72
 Identities = 168/488 (34%), Positives = 258/488 (52%), Gaps = 33/488 (6%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60
           M   A +  +  E  C IC+ +L +P++I+CGH+FC SC+   W    E     + CP+C
Sbjct: 1   MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQEL----FPCPVC 56

Query: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGD---LCERHGEKLKMFCKEDVLIMC 117
           R   Q  + R N QL  ++E  +LL+       K +   LCE+H + L +FCKED++++C
Sbjct: 57  RHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLC 116

Query: 118 EACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQV 177
             C+Q P+H+ H V P+E  A  Y+      ++ LKK+  +  KL   + K+    +  V
Sbjct: 117 PLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMV 176

Query: 178 ETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQ 237
           E ++Q +  EFE   + L+++Q           A L+ L  E  +  QKL  N +     
Sbjct: 177 ENQRQELSSEFEHLNQFLDREQQ----------AVLSRLAEEEKDNQQKLSANITAFSNY 226

Query: 238 SQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTD-C----RVL 292
           S  L   ++++ E S+     +L  I+ +   S++ S   P   S+ LK D C    +  
Sbjct: 227 SATLKSQLSKVVELSELSELELLSQIK-IFYESENES--SPSIFSIHLKRDGCSFPPQYS 283

Query: 293 GLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQC 352
            L+ I+K +  ++ LDP+TA+  LIVSED+KRV +    QK+P  P+RF    +VLG   
Sbjct: 284 ALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPY 343

Query: 353 ISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYP 412
             SGRH+WE+EVGD+SEW +G+CK ++  K     S     W I L+    +  G    P
Sbjct: 344 FHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTP 403

Query: 413 ILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNN 472
           +L L V  R +GIF+DYE  +ISFYN+ +  SHI TF    F G L PYF     +G  +
Sbjct: 404 LL-LEVKARAIGIFLDYEMGEISFYNMAE-KSHICTFTD-TFTGPLRPYF----YVGP-D 455

Query: 473 TAPLAICS 480
           + PL IC+
Sbjct: 456 SQPLRICT 463


>gi|68160935 tripartite motif-containing 17 isoform 2 [Homo sapiens]
          Length = 450

 Score =  268 bits (684), Expect = 1e-71
 Identities = 162/441 (36%), Positives = 242/441 (54%), Gaps = 24/441 (5%)

Query: 31  CGHSFCHSCLSGLWEIP----GESQNWG-YTCPLCRAPVQPRNLRPNWQLANVVEKVRLL 85
           CGH+FC +C+   WE      G  +  G + CP CR     RNL PN  L  V E   + 
Sbjct: 4   CGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAE---MA 60

Query: 86  RLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWEL 145
           + HPG+  K DLC+ H E LK+FC++D   +C  C +S EH  H V+P E+    YK +L
Sbjct: 61  QQHPGLQ-KQDLCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYKLKL 119

Query: 146 HEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQL 205
            E +E+L+++      L+  E +  A W+ +V+ R++ IV EFEK    L +        
Sbjct: 120 EEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVE-------- 171

Query: 206 GAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQE 265
             E    L +L+ E  ET  +L  + + L +Q   L  ++ +L+ERS +    MLQD++E
Sbjct: 172 --EEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKE 229

Query: 266 VLNRSKSWSLQQPEPI-SLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKR 324
            L+R  + S+Q PE       +T CRV G  E+L+ +  DV  D  +AY  L++ E R+R
Sbjct: 230 PLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVPDATSAYPYLLLYESRQR 289

Query: 325 VHYGDTNQKLP-DNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSE--WGLGVCKQNVDR 381
            + G + +     + +RF  Y   +G    SSGRHYWEV +    +  W LGVC+ NV R
Sbjct: 290 RYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSR 349

Query: 382 KEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTD 441
           K+ V   P  GFWV++L KG +Y +       + L  PP  +GIF+D+EA ++SFY+V+D
Sbjct: 350 KDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSD 409

Query: 442 CGSHIFTFPRYPFPGRLLPYF 462
            GSH+ T+ +  FPG L P+F
Sbjct: 410 -GSHLHTYSQATFPGPLQPFF 429


>gi|31542779 tripartite motif family-like 1 [Homo sapiens]
          Length = 468

 Score =  262 bits (670), Expect = 5e-70
 Identities = 169/487 (34%), Positives = 264/487 (54%), Gaps = 27/487 (5%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60
           M    L+E + EE+ C IC+ +   P++ +CGHSFC  CL   WE      N   +CP C
Sbjct: 1   MSTADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWE----EHNTPLSCPEC 56

Query: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCE-- 118
              ++  + + N +L  +    R LR      L+ +  +  G   +M      L   E  
Sbjct: 57  WRTLEGPHFQSNERLGRLASIARQLR---SQVLQSE--DEQGSYGRMPTTAKALSDDEQG 111

Query: 119 -ACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQV 177
            +   +  H A+ V    +    ++ +L E L  L+  ++EA  +   E++R    + + 
Sbjct: 112 GSAFVAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEET 171

Query: 178 ETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQ 237
           +T KQ +V E+ K  + L++++    QL          L++E  E M+KL  N  +L QQ
Sbjct: 172 KTCKQVVVSEYMKMHQFLKEEEQLQLQL----------LEQEEKENMRKLRNNEIKLTQQ 221

Query: 238 SQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREI 297
            + L +MIA+++  SQ      L++++  L RS+   LQ PE  + EL   CR+ G++E+
Sbjct: 222 IRSLSKMIAQIESSSQSSAFESLEEVRGALERSEPLLLQCPEATTTELSL-CRITGMKEM 280

Query: 298 LKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGR 357
           L+ ++ ++ LDP TA + L++SED K V YG + Q+LPDNPERF +   VLG+Q  +SGR
Sbjct: 281 LRKFSTEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGR 340

Query: 358 HYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLP 417
           HYWEVEVG+++EW +G+CK +V RK  +   P   F +I L+ G++Y       P+    
Sbjct: 341 HYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSS-PLKGQH 399

Query: 418 V--PPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAP 475
           V  P  +VG+F+DYE+  I+FYN TD  S I++FP+  F   L P FSPC      NT P
Sbjct: 400 VREPVCKVGVFLDYESGHIAFYNGTD-ESLIYSFPQASFQEALRPIFSPCLPNEGTNTDP 458

Query: 476 LAICSLD 482
           L ICSL+
Sbjct: 459 LTICSLN 465


>gi|22749269 ring finger protein 129 [Homo sapiens]
          Length = 471

 Score =  245 bits (625), Expect = 7e-65
 Identities = 168/495 (33%), Positives = 261/495 (52%), Gaps = 42/495 (8%)

Query: 4   TALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAP 63
           TALV  + EE +CPIC+ +L++P++I+CGH+FC SCLS  W+   ++    + CP+CR  
Sbjct: 5   TALVN-LQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDT----FPCPVCRFC 59

Query: 64  VQPRNLRPNWQLANVVEKVRLLRLHPGMGLK---GDLCERHGEKLKMFCKEDVLIMCEAC 120
              ++ R N QL N+ E  + L++      +     +CE+H + L +FC +D+ I+C  C
Sbjct: 60  FPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQC 119

Query: 121 SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR 180
           S S +H+ H + P++  A  ++  L  +LE L+   E   K+ + +  ++   K +VE +
Sbjct: 120 SFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYK 179

Query: 181 KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV 240
           ++ I  EFE+ +  L+ +Q             L  +Q E    + KL  N  EL      
Sbjct: 180 REEINSEFEQIRLFLQNEQE----------MILRQIQDEEMNILAKLNENLVELSDYVST 229

Query: 241 LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSW-----SLQQPEPISLEL-----KTDCR 290
           L  ++ E++ +S       +Q   E+L ++KS      +L+ PE  S  L         +
Sbjct: 230 LKHLLREVEGKS-------VQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQ 282

Query: 291 VLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGS 350
             GL  I+K +  DV LD +TA+ +L+VSEDRK V Y    + +  +P RFY    VLGS
Sbjct: 283 YSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGS 342

Query: 351 QCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDE 410
           Q  SSGRHYWEVEVG++ +W LGVC+  + R      S   GFW I     + Y A   +
Sbjct: 343 QRFSSGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPK 402

Query: 411 YPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGT 470
              L   V P ++GIF+DYE  D+SFYN+ D  S ++TF    F   + PYF      GT
Sbjct: 403 TTQLLPVVKPSKIGIFLDYELGDLSFYNMND-RSILYTF-NDCFTEAVWPYF----YTGT 456

Query: 471 NNTAPLAICSLDGED 485
            ++ PL ICS+   +
Sbjct: 457 -DSEPLKICSVSDSE 470


>gi|157426896 tripartite motif-containing 10 isoform 2 [Homo
           sapiens]
          Length = 395

 Score =  244 bits (622), Expect = 2e-64
 Identities = 134/379 (35%), Positives = 216/379 (56%), Gaps = 31/379 (8%)

Query: 1   MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC 60
           M   A V ++ +EV CPIC   LREP++IDCGH+FC +CL+   EIPG       TCPLC
Sbjct: 1   MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC 60

Query: 61  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGL-KGDLCERHGEKLKMFCKEDVLIMCEA 119
           + P +P + RPNWQLANVVE +  L+L   +GL + D+C+ HGEK+  FC++D + +C  
Sbjct: 61  KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVV 120

Query: 120 CSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVET 179
           C ++ EH  H++  +ED A  Y+ ++H+ L+ L+KE+EE  +++  E KR      QV T
Sbjct: 121 CREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVST 180

Query: 180 RKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQ 239
           ++Q ++ EF   ++ LE++Q          +  LA L+ +  + ++  + +  +L+   +
Sbjct: 181 KRQQVISEFAHLRKFLEEQQ----------SILLAQLESQDGDILR--QRDEFDLLVAGE 228

Query: 240 V--LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCR-----VL 292
           +     +I EL+E+++RP R +L DI+  L R ++   ++P  +S EL    R      L
Sbjct: 229 ICRFSALIEELEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQAL 288

Query: 293 GLREILKTY-----------AADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERF 341
            L+  +K +            A + LDP T++ +L++SED +R  +    Q  PDNP+RF
Sbjct: 289 PLQREMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRF 348

Query: 342 YRYNIVLGSQCISSGRHYW 360
            R   VL    I+ GRH W
Sbjct: 349 DRATCVLAHTGITGGRHTW 367


>gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo
           sapiens]
          Length = 474

 Score =  243 bits (621), Expect = 2e-64
 Identities = 163/496 (32%), Positives = 254/496 (51%), Gaps = 69/496 (13%)

Query: 8   EAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPR 67
           E I EE+ CPIC+ + ++P+SI+CGH+FC  CL   W  PG      + CP CR P  P 
Sbjct: 4   EDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWA-PGGGP---FPCPECRHPSAPA 59

Query: 68  NLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHE 127
            LRPNW LA + EK +  RL P   +   LC RH E L++FC++D   +C  C +S EH+
Sbjct: 60  ALRPNWALARLTEKTQRRRLGP---VPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQ 116

Query: 128 AHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWE 187
            H++ P+++    Y+ +L ++  +L  + ++   L+  E K    WK ++++++  I  E
Sbjct: 117 THAMAPIDEAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTE 176

Query: 188 FEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAE 247
           F K           H  L  E    L  L +E  ET +KL  N  +L Q    L ++I E
Sbjct: 177 FSKL----------HNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILE 226

Query: 248 LKERSQRPVRWMLQDIQEVLNRSK----SWSLQQPEPISLELKTDCRVLGLREILKTYAA 303
           + E+SQ P   +LQ+ +EVL RS+    ++SL+     ++++KT C++  ++E+LK +  
Sbjct: 227 VGEKSQAPTLELLQNPKEVLTRSEIQDVNYSLE-----AVKVKTVCQIPLMKEMLKRFQV 281

Query: 304 DVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLP------------DNP------ERFYRYN 345
            V L  DTA+ +L+ S++ + V    +    P             NP      ERF    
Sbjct: 282 AVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLP 341

Query: 346 IVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNV----DRKEVVYLSPHYGFWVIRLRKG 401
            VLG    +SG+HYWEVE  D  E  +GVC+++V    DR +   +SP  G W I     
Sbjct: 342 CVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSK---MSPDVGIWAI----- 393

Query: 402 NEYRAGTDEYPILSLPVPP-------RRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPF 454
             Y +    +P++  P  P        RVG+++D    ++SFY+  D G H+ TF     
Sbjct: 394 --YWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVD-GVHLHTF-SCSS 449

Query: 455 PGRLLPYF--SPCYSI 468
             RL P+F  SP  S+
Sbjct: 450 VSRLRPFFWLSPLASL 465


>gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]
          Length = 511

 Score =  243 bits (621), Expect = 2e-64
 Identities = 168/502 (33%), Positives = 246/502 (49%), Gaps = 50/502 (9%)

Query: 5   ALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYT-------- 56
           AL   +  E  C IC+   REP+S++CGHSFC +C+   WE PG       T        
Sbjct: 18  ALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP 77

Query: 57  CPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGM-GLKGDL----------CERHGEKL 105
           CP CR P +P  LRPN QLA V   +R   L     G  G            C +HGE  
Sbjct: 78  CPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPF 137

Query: 106 KMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVG 165
           K++C++D   +C  C ++ EH  H+V+P+++   E K  L   L  LKKE E+       
Sbjct: 138 KLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRST 197

Query: 166 ERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQ 225
           E+K +     Q+   ++ +  EF+  +  L +++   R LG      L  L RE A   Q
Sbjct: 198 EKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEG--RLLGR-----LEELSREVA---Q 247

Query: 226 KLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLEL 285
           K   N ++L  +   L ++ ++++E +Q+P    LQ+ +  L+R  +    +P  +S E+
Sbjct: 248 KQNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKPTTVSSEM 307

Query: 286 KT-----DCRVLGLREILKTYAADVR------------LDPDTAYSRLIVSEDRKRVHYG 328
           K        +   L+ +LK +  D+R            LDPDTA  RLI+S D K V  G
Sbjct: 308 KNKVWNVSLKTFVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLDLKGVRLG 367

Query: 329 DTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLS 388
           +  Q LP++P RF     VL S   SSGRH+WEVEVG +  W  GV +++V RK +   +
Sbjct: 368 ERAQDLPNHPCRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFT 427

Query: 389 PHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFT 448
           P  G W ++L  G  +   + E   LS      RV + +D E   +SFY V D   H++T
Sbjct: 428 PEEGVWALQLNGGQYWAVTSPERSPLSCG-HLSRVRVALDLEVGAVSFYAVEDM-RHLYT 485

Query: 449 FPRYPFPGRLLPYFSPCYSIGT 470
           F R  F  R+ P FS C S GT
Sbjct: 486 F-RVNFQERVFPLFSVC-STGT 505


>gi|14670266 tripartite motif protein TRIM4 isoform alpha [Homo
           sapiens]
          Length = 500

 Score =  232 bits (591), Expect = 7e-61
 Identities = 166/522 (31%), Positives = 256/522 (49%), Gaps = 95/522 (18%)

Query: 8   EAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPR 67
           E I EE+ CPIC+ + ++P+SI+CGH+FC  CL   W  PG      + CP CR P  P 
Sbjct: 4   EDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNW-APGGGP---FPCPECRHPSAPA 59

Query: 68  NLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHE 127
            LRPNW LA + EK +  RL P   +   LC RH E L++FC++D   +C  C +S EH+
Sbjct: 60  ALRPNWALARLTEKTQRRRLGP---VPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQ 116

Query: 128 AHSVVPMEDVAWEYK----------WE---LHEALEHLKKEQ-------------EEAWK 161
            H++ P+++    Y+          W+   +   L H K+E+             ++   
Sbjct: 117 THAMAPIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHSKQEEKLLKSQRNLVAKMKKVMH 176

Query: 162 LEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAA 221
           L+  E K    WK ++++++  I  EF K           H  L  E    L  L +E  
Sbjct: 177 LQDVEVKNATQWKDKIKSQRMRISTEFSKL----------HNFLVEEEDLFLQRLNKEEE 226

Query: 222 ETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSK----SWSLQQ 277
           ET +KL  N  +L Q    L ++I E+ E+SQ P   +LQ+ +EVL RS+    ++SL+ 
Sbjct: 227 ETKKKLNENTLKLNQTIASLKKLILEVGEKSQAPTLELLQNPKEVLTRSEIQDVNYSLE- 285

Query: 278 PEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLP-- 335
               ++++KT C++  ++E+LK +   V L  DTA+ +L+ S++ + V    +    P  
Sbjct: 286 ----AVKVKTVCQIPLMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVF 341

Query: 336 ----------DNP------ERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNV 379
                      NP      ERF     VLG    +SG+HYWEVE  D  E  +GVC+++V
Sbjct: 342 SSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDV 401

Query: 380 ----DRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPP-------RRVGIFVD 428
               DR +   +SP  G W I       Y +    +P++  P  P        RVG+++D
Sbjct: 402 MGITDRSK---MSPDVGIWAI-------YWSAAGYWPLIGFPGTPTQQEPALHRVGVYLD 451

Query: 429 YEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYF--SPCYSI 468
               ++SFY+  D G H+ TF       RL P+F  SP  S+
Sbjct: 452 RGTGNVSFYSAVD-GVHLHTF-SCSSVSRLRPFFWLSPLASL 491


>gi|4557743 Mediterranean fever protein [Homo sapiens]
          Length = 781

 Score =  230 bits (587), Expect = 2e-60
 Identities = 146/415 (35%), Positives = 224/415 (53%), Gaps = 39/415 (9%)

Query: 98  CERHGEKLKM-FCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQ 156
           C+RH +++++ FC++    +C  CS S EH+ H V P+E+VA E+K ++ + LEHLKK +
Sbjct: 375 CKRHLKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLEHLKKLR 434

Query: 157 EEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASL 216
           +   +      ++  ++  Q E  KQ +  + E+    LE+++             +ASL
Sbjct: 435 KSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEH----------FFVASL 484

Query: 217 QREAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKS---- 272
           +       Q  +   + + Q   +L  +I EL+ +  +    +LQDI ++L+R+K+    
Sbjct: 485 EDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVP 544

Query: 273 --WSLQQP-------------------EPISLELKTDCRVLGLREIL--KTYAADVRLDP 309
             W+  Q                    +  S  L+++  +  + E++  + +A +V LD 
Sbjct: 545 EKWTTPQEIKQKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDA 604

Query: 310 DTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSE 369
           +TAY  LI S+D K V  G+  ++LPD P+RF    IVLGS    SGR YWEVEVGD++ 
Sbjct: 605 ETAYPNLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTA 664

Query: 370 WGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDY 429
           W LG CK ++ RK  + LSP  G+WV+ + K NEY+A +     L +  PP+RVGIFVDY
Sbjct: 665 WILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDY 724

Query: 430 EAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGE 484
               ISFYNVT   SHI+TF    F G L P FSP    G  NTAPL IC + G+
Sbjct: 725 RVGSISFYNVT-ARSHIYTFASCSFSGPLQPIFSPGTRDGGKNTAPLTICPVGGQ 778


>gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]
          Length = 630

 Score =  226 bits (577), Expect = 3e-59
 Identities = 153/454 (33%), Positives = 227/454 (50%), Gaps = 63/454 (13%)

Query: 55  YTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLK---GDLCERHGEKLKMFCKE 111
           +TCP CR     R+ RPN QLAN+V+ +R +   PG G +     +C +H E LK+FC+ 
Sbjct: 181 FTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEV 240

Query: 112 DVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTA 171
           D   +C  C +S  H+ HSVVP+E+V  EYK +L   +E L+K  E   K++  E +R  
Sbjct: 241 DEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVT 300

Query: 172 TWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNH 231
             K Q+++   ++  EF +  R L ++Q              A L+R   E M + +L  
Sbjct: 301 ELKSQMKSELAAVASEFGRLTRFLAEEQ--------------AGLERRLRE-MHEAQLGR 345

Query: 232 -----SELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPE------- 279
                S L +Q+  L R++AE +ERSQ+    +LQDI+E  NR +   LQ PE       
Sbjct: 346 AGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPC 405

Query: 280 -PISLELKTDCRVLGL-REILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDN 337
            P S +  TD  V  + R   +    D+ LDPDTA+  L++S DR+ V   +  Q++ D+
Sbjct: 406 QPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADH 465

Query: 338 PERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVV------------ 385
           P+RF     VLG+Q   SGRHYWEVEVG R  W +G  +++   KE V            
Sbjct: 466 PKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDA 525

Query: 386 YLSPHY----------------GFWVIRLRKGNEYRA-GTDEYPILSLPVPPRRVGIFVD 428
             S H+                  W +    G  Y+A  + E  +LS    PRR G+++D
Sbjct: 526 SSSRHHHRRRRLHLPQQPLLQREVWCVG-TNGKRYQAQSSTEQTLLSPSEKPRRFGVYLD 584

Query: 429 YEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYF 462
           YEA  + FYN  +  +H+ TF       R+ P+F
Sbjct: 585 YEAGRLGFYN-AETLAHVHTFSAAFLGERVFPFF 617



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 17/38 (44%), Positives = 26/38 (68%)

Query: 7  VEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLW 44
          V+ + EE  C IC+ +  +P+SI CGH+FC  C++ LW
Sbjct: 11 VQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLW 48


>gi|169202375 PREDICTED: tripartite motif-containing protein
           64B-like [Homo sapiens]
          Length = 449

 Score =  215 bits (547), Expect = 8e-56
 Identities = 139/464 (29%), Positives = 230/464 (49%), Gaps = 33/464 (7%)

Query: 7   VEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQP 66
           ++    E+ C IC+ +  +P++IDCGHSFC  CL     +  E       CP CR   + 
Sbjct: 6   LQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLC----LCSEEGRAPMRCPSCRKTSEK 61

Query: 67  RNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEH 126
            N   N  L  +    R  R    +    ++C  H E  ++FC+ D  ++C  CS+SPEH
Sbjct: 62  PNFNTNLVLKKLSSLARQTRPQ-NINSSDNICVLHEETKELFCEADKRLLCGPCSESPEH 120

Query: 127 EAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGER----KRTATW---KIQVET 179
            AHS  P+        W   E  E L KE +  W++    R    + T+T+   K  V  
Sbjct: 121 MAHSHSPI-------GWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYVSV 173

Query: 180 RKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQ 239
           RK+ I  +++K    L++++  H          L +L+REA E  Q+L+ +   + Q  +
Sbjct: 174 RKRIITIQYQKMPIFLDEEEQRH----------LQALEREAEELFQQLQDSQVRMTQHLE 223

Query: 240 VLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILK 299
            +  M  EL E    P   +LQD++ V  R+    +Q+P+P++ EL + C + G+ ++L 
Sbjct: 224 RMKDMYRELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLN 282

Query: 300 TYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHY 359
            +  D  L  +     + +SED + V +GD +   P +P+    +  V G+Q  +SG+HY
Sbjct: 283 NFRVDSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGVDSF-AVWGAQAFTSGKHY 341

Query: 360 WEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILS-LPV 418
           WEV+V   S W LGVC+ +        +     F++I  ++ N Y   T+  P++  +  
Sbjct: 342 WEVDVTLSSNWILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQR 401

Query: 419 PPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYF 462
           P  RVG+F+DY+   +SF++V+  GS I+ FP   F   L P+F
Sbjct: 402 PLGRVGVFLDYDNGSVSFFDVSK-GSLIYGFPPSSFSSPLRPFF 444


>gi|210147600 tripartite motif-containing 64 [Homo sapiens]
          Length = 449

 Score =  210 bits (535), Expect = 2e-54
 Identities = 138/464 (29%), Positives = 229/464 (49%), Gaps = 33/464 (7%)

Query: 7   VEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQP 66
           ++    E+ C IC+ +  +P++IDCGHSFC  CL     +  E       CP CR   + 
Sbjct: 6   LQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLC----LCSEEGRAPMRCPSCRKISEK 61

Query: 67  RNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEH 126
            N   N  L  +    R  R    +    ++C  H E  ++FC+ D  ++C  CS+SPEH
Sbjct: 62  PNFNTNVVLKKLSSLARQTRPQ-NINSSDNICVLHEETKELFCEADKRLLCGPCSESPEH 120

Query: 127 EAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGER----KRTATW---KIQVET 179
            AHS  P+        W   E  E L KE +  W++    R    + T T+   K  V  
Sbjct: 121 MAHSHSPI-------GWAAEECREKLIKEMDYLWEINQETRNNLNQETRTFHSLKDYVSV 173

Query: 180 RKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQ 239
           RK+ I  +++K    L++++  H          L +L+REA E  Q+L+ +   + Q  +
Sbjct: 174 RKRIITIQYQKMPIFLDEEEQRH----------LQALEREAEELFQQLQDSQVRMTQHLE 223

Query: 240 VLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILK 299
            +  M  EL E    P   +LQD++ V  R+    +Q+P+P++ EL + C + G+ ++L 
Sbjct: 224 RMKDMYRELWETCHVPDVELLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLN 282

Query: 300 TYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHY 359
            +  D  L  +     + +SED + V +GD +   P +P+    +  V G+Q  +SG+HY
Sbjct: 283 NFRVDSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGVDSF-AVWGAQAFTSGKHY 341

Query: 360 WEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILS-LPV 418
           WEV+V   S W LGVC+ +        +     F++I  ++ N Y   T+  P++  +  
Sbjct: 342 WEVDVTLSSNWILGVCQDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQR 401

Query: 419 PPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYF 462
           P  +VG+F+DY+   +SF++V+  GS I+ FP   F   L P+F
Sbjct: 402 PLGQVGVFLDYDNGSVSFFDVSK-GSLIYGFPPSSFSSPLRPFF 444


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,434,326
Number of Sequences: 37866
Number of extensions: 1031739
Number of successful extensions: 4208
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 3149
Number of HSP's gapped (non-prelim): 736
length of query: 485
length of database: 18,247,518
effective HSP length: 106
effective length of query: 379
effective length of database: 14,233,722
effective search space: 5394580638
effective search space used: 5394580638
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.