Search of human proteins with 37551995

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37551995 PREDICTED: hypothetical protein [Homo sapiens]
         (867 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37551995 PREDICTED: hypothetical protein [Homo sapiens]           1739   0.0  
gi|89057602 PREDICTED: hypothetical protein [Homo sapiens]           1727   0.0  
gi|169214048 PREDICTED: hypothetical protein [Homo sapiens]          1723   0.0  
gi|169203189 PREDICTED: hypothetical protein LOC338667 [Homo sap...   105   2e-22
gi|169203683 PREDICTED: hypothetical protein LOC338667 [Homo sap...   105   2e-22
gi|169202109 PREDICTED: hypothetical protein LOC338667 [Homo sap...   105   2e-22
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    87   7e-17
gi|40254891 hypothetical protein FLJ20674 [Homo sapiens]               87   9e-17
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             86   1e-16
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    85   3e-16
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    85   3e-16
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]         83   1e-15
gi|21314600 carcinoembryonic antigen-related cell adhesion molec...    82   2e-15
gi|68161541 carcinoembryonic antigen-related cell adhesion molec...    80   1e-14
gi|19923195 carcinoembryonic antigen-related cell adhesion molec...    80   1e-14
gi|40255013 carcinoembryonic antigen-related cell adhesion molec...    79   1e-14
gi|98986445 carcinoembryonic antigen-related cell adhesion molec...    78   4e-14
gi|194328712 pregnancy specific beta-1-glycoprotein 8 isoform c ...    74   4e-13
gi|194328710 pregnancy specific beta-1-glycoprotein 8 isoform b ...    74   4e-13
gi|118572606 hemicentin 1 [Homo sapiens]                               74   6e-13
gi|164663836 pregnancy specific beta-1-glycoprotein 11 isoform 1...    73   1e-12
gi|194097369 pregnancy specific beta-1-glycoprotein 5 [Homo sapi...    73   1e-12
gi|194097367 pregnancy specific beta-1-glycoprotein 5 [Homo sapi...    73   1e-12
gi|51510887 pregnancy specific beta-1-glycoprotein 8 isoform a [...    72   2e-12
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ...    70   1e-11
gi|10835203 advanced glycosylation end product-specific receptor...    69   2e-11
gi|4506175 pregnancy specific beta-1-glycoprotein 6 isoform a [H...    68   3e-11
gi|47419900 pregnancy specific beta-1-glycoprotein 4 isoform 2 [...    68   3e-11
gi|157805480 pregnancy specific beta-1-glycoprotein 7 precursor ...    67   5e-11
gi|73661174 pregnancy specific beta-1-glycoprotein 6 isoform b [...    67   7e-11

>gi|37551995 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 867

 Score = 1739 bits (4505), Expect = 0.0
 Identities = 867/867 (100%), Positives = 867/867 (100%)

Query: 1   MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW 60
           MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW
Sbjct: 1   MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW 60

Query: 61  KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP 120
           KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP
Sbjct: 61  KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP 120

Query: 121 DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK 180
           DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK
Sbjct: 121 DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK 180

Query: 181 FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP 240
           FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP
Sbjct: 181 FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP 240

Query: 241 GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP 300
           GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP
Sbjct: 241 GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP 300

Query: 301 LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG 360
           LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG
Sbjct: 301 LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG 360

Query: 361 DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA 420
           DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA
Sbjct: 361 DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA 420

Query: 421 GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR 480
           GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR
Sbjct: 421 GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR 480

Query: 481 RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV 540
           RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV
Sbjct: 481 RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV 540

Query: 541 SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVAL 600
           SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVAL
Sbjct: 541 SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVAL 600

Query: 601 EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
           EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG
Sbjct: 601 EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660

Query: 661 AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW 720
           AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW
Sbjct: 661 AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW 720

Query: 721 VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI 780
           VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI
Sbjct: 721 VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI 780

Query: 781 VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW 840
           VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW
Sbjct: 781 VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW 840

Query: 841 PLDLKVPLEDHSSTRAYQAQTPVQLSL 867
           PLDLKVPLEDHSSTRAYQAQTPVQLSL
Sbjct: 841 PLDLKVPLEDHSSTRAYQAQTPVQLSL 867


>gi|89057602 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 881

 Score = 1727 bits (4472), Expect = 0.0
 Identities = 860/862 (99%), Positives = 860/862 (99%)

Query: 1   MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW 60
           MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW
Sbjct: 1   MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW 60

Query: 61  KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP 120
           KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP
Sbjct: 61  KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP 120

Query: 121 DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK 180
           DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK
Sbjct: 121 DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK 180

Query: 181 FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP 240
           FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP
Sbjct: 181 FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP 240

Query: 241 GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP 300
           GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP
Sbjct: 241 GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP 300

Query: 301 LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG 360
           LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG
Sbjct: 301 LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG 360

Query: 361 DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA 420
           DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA
Sbjct: 361 DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA 420

Query: 421 GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR 480
           GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR
Sbjct: 421 GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR 480

Query: 481 RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV 540
           RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV
Sbjct: 481 RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV 540

Query: 541 SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVAL 600
           SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVAL
Sbjct: 541 SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVAL 600

Query: 601 EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
           EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG
Sbjct: 601 EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660

Query: 661 AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW 720
           AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW
Sbjct: 661 AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW 720

Query: 721 VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI 780
           VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI
Sbjct: 721 VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI 780

Query: 781 VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW 840
           VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW
Sbjct: 781 VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW 840

Query: 841 PLDLKVPLEDHSSTRAYQAQTP 862
           PLDLKVPLEDHSSTRAYQA  P
Sbjct: 841 PLDLKVPLEDHSSTRAYQATDP 862


>gi|169214048 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 881

 Score = 1723 bits (4462), Expect = 0.0
 Identities = 858/862 (99%), Positives = 859/862 (99%)

Query: 1   MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW 60
           MD PQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW
Sbjct: 1   MDTPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSW 60

Query: 61  KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP 120
           KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP
Sbjct: 61  KVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFP 120

Query: 121 DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK 180
           DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK
Sbjct: 121 DISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESK 180

Query: 181 FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP 240
           FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP
Sbjct: 181 FSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGP 240

Query: 241 GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP 300
           GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP
Sbjct: 241 GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP 300

Query: 301 LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG 360
           LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG
Sbjct: 301 LPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG 360

Query: 361 DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA 420
           DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA
Sbjct: 361 DQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTA 420

Query: 421 GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR 480
           GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR
Sbjct: 421 GSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR 480

Query: 481 RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV 540
           RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV
Sbjct: 481 RRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPV 540

Query: 541 SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVAL 600
           SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAET+LGEAEVAL
Sbjct: 541 SSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETQLGEAEVAL 600

Query: 601 EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
           EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG
Sbjct: 601 EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660

Query: 661 AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW 720
           AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW
Sbjct: 661 AGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDW 720

Query: 721 VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI 780
           VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI
Sbjct: 721 VSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGI 780

Query: 781 VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW 840
           VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW
Sbjct: 781 VLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISW 840

Query: 841 PLDLKVPLEDHSSTRAYQAQTP 862
           PLDLKVPLEDHSSTRAYQA  P
Sbjct: 841 PLDLKVPLEDHSSTRAYQATDP 862


>gi|169203189 PREDICTED: hypothetical protein LOC338667 [Homo
           sapiens]
          Length = 859

 Score =  105 bits (262), Expect = 2e-22
 Identities = 158/677 (23%), Positives = 240/677 (35%), Gaps = 118/677 (17%)

Query: 199 LAVLVGTTIRLPLVPIPNPGP-----------------PTSLVVWRRGSKVLAAGGLGPG 241
           LAVLV   +  P V + NP P                 P +     R  + L    +G  
Sbjct: 141 LAVLV--PVSKPQVRLSNPSPVEGASVVATCAVREGTEPVTFAWQHRAPRGLGEALVGVT 198

Query: 242 APLISLDPAHRDHLRFDQARG---------------VLELASAQ------------LDDA 274
            PL  LDP +R HL +                    V+ LA+              LD A
Sbjct: 199 EPLFQLDPVNRTHLGWYMCSASNSVNRLSSDGAFLDVIYLATRTCYKKKSVSGIRLLDGA 258

Query: 275 GVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPE-----------TEEG-----AA 318
           G+   +  R  ++     FTV V       +V+   P+           TEEG       
Sbjct: 259 GLRRFKE-RGRMASYLSVFTVAVCGNCELRTVEADGPDKPVITMEPLGLTEEGFWASERE 317

Query: 319 ELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTC 378
           E+ L CL          W RD   +                G   +I R  R     YTC
Sbjct: 318 EVTLSCLAASNPPSHYVWLRDHTQVHT--------------GPTYVIARAGRVHTGLYTC 363

Query: 379 RVRSPF--GHREAAADVSVFYGPD-PPTITVSSDRDAAPARFVTAGSNVTLRCA-AASRP 434
             R+ +     +    ++++Y P+  P+  V    +A           VTL CA     P
Sbjct: 364 LARNSYLDTRTQTTVQLTIYYPPEGQPSCAVHPSSEA-----------VTLLCAWPGGLP 412

Query: 435 PADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
           PA + W          P+       A        + C   +P         + L     P
Sbjct: 413 PAQLQWEGPQGPGPTAPSNVTWSHAAAQLPSGSVFTCTGQHPALAPPALCTVMLWE---P 469

Query: 495 PGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRL 554
            G P C      GD+ +   C WPGG P A+L +    +    G  SS+ +  + A   L
Sbjct: 470 LGRPTCWSTATMGDQFIMLSCEWPGGEPPATLGWLDEQQQPLGGSSSSMAVHLLQAQEDL 529

Query: 555 SGVPITCLARHLVATRT--CTVTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRAS 612
           +G   TC   HL+ T    C +  EAP+  +  P V+    GEA +     G  PP++  
Sbjct: 530 AGREFTCRGTHLLRTPDPHCHLQLEAPQLDVAEPRVSVLEGGEAWLECSLRGGTPPAQLL 589

Query: 613 WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLD--WDLGNYSVLCSGALGAGGDQITL-- 668
           W    +     G S   L  +G +L +G +  D     G Y  +   A+G     + L  
Sbjct: 590 WLGPQQQKVDPGTSGFMLHPEGAQLRLGIYDADPAHHRGTYQCVARNAVGNSSQSVLLEV 649

Query: 669 ----IGPSISSWRLQ--RARDAAVLTWDVERGALISSFEIQ--AWPDGPALGRTSTYRDW 720
                 P+++  RL   R R    L W +     ++ F +Q  A   GP  G   T    
Sbjct: 650 LRYPAPPNVTISRLTYGRHRREVQLQWAILGPGNLTGFLVQRKASALGPGAGAWETAASD 709

Query: 721 VSLLILGPQERSAVVPLPPRNPGT-WTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAG 779
           +      P+ R     L   +PG  + FRIL +     G PS+ ++    P  ++ A+ G
Sbjct: 710 IE-----PESRGR--RLGGLDPGVLYAFRILALNHHTAGHPSEVKIPADPPFSAYPAVLG 762

Query: 780 IVLGSLLGLALLAVLLL 796
              G+ + +A +A LL+
Sbjct: 763 -AAGTGMVVATVASLLV 778


>gi|169203683 PREDICTED: hypothetical protein LOC338667 [Homo
           sapiens]
          Length = 859

 Score =  105 bits (261), Expect = 2e-22
 Identities = 158/677 (23%), Positives = 240/677 (35%), Gaps = 118/677 (17%)

Query: 199 LAVLVGTTIRLPLVPIPNPGP-----------------PTSLVVWRRGSKVLAAGGLGPG 241
           LAVLV   +  P V + NP P                 P +     R  + L    +G  
Sbjct: 141 LAVLV--PVSKPQVRLSNPSPVEGASVVATCAVREGTEPVTFAWQHRAPRGLGEALVGVT 198

Query: 242 APLISLDPAHRDHLRFDQARG---------------VLELASAQ------------LDDA 274
            PL  LDP +R HL +                    V+ LA+              LD A
Sbjct: 199 EPLFQLDPVNRTHLGWYMCSASNSVNRLSSDGAFLDVIYLATRTCYKKKSVSGIRLLDGA 258

Query: 275 GVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPE-----------TEEG-----AA 318
           G+   +  R  ++     FTV V       +V+   P+           TEEG       
Sbjct: 259 GLRRFKE-RGRMASYLSVFTVAVCGNCELRTVEADGPDKPVITMEPLGLTEEGFWASERE 317

Query: 319 ELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTC 378
           E+ L CL          W RD   +                G   +I R  R     YTC
Sbjct: 318 EVTLSCLAASNPPSHYVWLRDHTQVHT--------------GPTYVIARAGRVHTGLYTC 363

Query: 379 RVRSPF--GHREAAADVSVFYGPD-PPTITVSSDRDAAPARFVTAGSNVTLRCA-AASRP 434
             R+ +     +    ++++Y P+  P+  V    +A           VTL CA     P
Sbjct: 364 LARNSYLDTRTQTTVQLTIYYPPEGQPSCAVHPSPEA-----------VTLLCAWPGGLP 412

Query: 435 PADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
           PA + W          P+       A        + C   +P         + L     P
Sbjct: 413 PAQLQWEGPQGPGPTAPSNVTWSHAAAQLPSGSVFTCTGQHPALAPPALCTVMLWE---P 469

Query: 495 PGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRL 554
            G P C      GD+ +   C WPGG P A+L +    +    G  SS+ +  + A   L
Sbjct: 470 LGRPTCWSTATMGDQFIMLSCEWPGGEPPATLGWLDEQQQPLGGSSSSMAVHLLQAQEDL 529

Query: 555 SGVPITCLARHLVATRT--CTVTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRAS 612
           +G   TC   HL+ T    C +  EAP+  +  P V+    GEA +     G  PP++  
Sbjct: 530 AGREFTCRGTHLLRTPDPHCHLQLEAPQLDVAEPRVSVLEGGEAWLECSLRGGTPPAQLL 589

Query: 613 WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLD--WDLGNYSVLCSGALGAGGDQITL-- 668
           W    +     G S   L  +G +L +G +  D     G Y  +   A+G     + L  
Sbjct: 590 WLGPQQQKVDPGTSGFMLHPEGAQLRLGIYDADPAHHRGTYQCVARNAVGNSSQSVLLEV 649

Query: 669 ----IGPSISSWRLQ--RARDAAVLTWDVERGALISSFEIQ--AWPDGPALGRTSTYRDW 720
                 P+++  RL   R R    L W +     ++ F +Q  A   GP  G   T    
Sbjct: 650 LRYPAPPNVTISRLTYGRHRREVQLQWAILGPGNLTGFLVQRKASALGPGAGAWETAASD 709

Query: 721 VSLLILGPQERSAVVPLPPRNPGT-WTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAG 779
           +      P+ R     L   +PG  + FRIL +     G PS+ ++    P  ++ A+ G
Sbjct: 710 IE-----PESRGR--RLGGLDPGVLYAFRILALNHHTAGHPSEVKIPADPPFSAYPAVLG 762

Query: 780 IVLGSLLGLALLAVLLL 796
              G+ + +A +A LL+
Sbjct: 763 -AAGTGMVVATVASLLV 778


>gi|169202109 PREDICTED: hypothetical protein LOC338667 [Homo
           sapiens]
          Length = 859

 Score =  105 bits (261), Expect = 2e-22
 Identities = 158/677 (23%), Positives = 240/677 (35%), Gaps = 118/677 (17%)

Query: 199 LAVLVGTTIRLPLVPIPNPGP-----------------PTSLVVWRRGSKVLAAGGLGPG 241
           LAVLV   +  P V + NP P                 P +     R  + L    +G  
Sbjct: 141 LAVLV--PVSKPQVRLSNPSPVEGASVVATCAVREGTEPVTFAWQHRAPRGLGEALVGVT 198

Query: 242 APLISLDPAHRDHLRFDQARG---------------VLELASAQ------------LDDA 274
            PL  LDP +R HL +                    V+ LA+              LD A
Sbjct: 199 EPLFQLDPVNRTHLGWYMCSASNSVNRLSSDGAFLDVIYLATRTCYKKKSVSGIRLLDGA 258

Query: 275 GVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPE-----------TEEG-----AA 318
           G+   +  R  ++     FTV V       +V+   P+           TEEG       
Sbjct: 259 GLRRFKE-RGRMASYLSVFTVAVCGNCELRTVEADGPDKPVITMEPLGLTEEGFWASERE 317

Query: 319 ELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTC 378
           E+ L CL          W RD   +                G   +I R  R     YTC
Sbjct: 318 EVTLSCLAASNPPSHYVWLRDHTQVHT--------------GPTYVIARAGRVHTGLYTC 363

Query: 379 RVRSPF--GHREAAADVSVFYGPD-PPTITVSSDRDAAPARFVTAGSNVTLRCA-AASRP 434
             R+ +     +    ++++Y P+  P+  V    +A           VTL CA     P
Sbjct: 364 LARNSYLDTRTQTTVQLTIYYPPEGQPSCAVHPSPEA-----------VTLLCAWPGGLP 412

Query: 435 PADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
           PA + W          P+       A        + C   +P         + L     P
Sbjct: 413 PAQLQWEGPQGPGPTAPSNVTWSHAAAQLPSGSVFTCTGQHPALAPPALCTVMLWE---P 469

Query: 495 PGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRL 554
            G P C      GD+ +   C WPGG P A+L +    +    G  SS+ +  + A   L
Sbjct: 470 LGRPTCWSTATMGDQFIMLSCEWPGGEPPATLGWLDEQQQPLGGSSSSMAVHLLQAQEDL 529

Query: 555 SGVPITCLARHLVATRT--CTVTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRAS 612
           +G   TC   HL+ T    C +  EAP+  +  P V+    GEA +     G  PP++  
Sbjct: 530 AGREFTCRGTHLLRTPDPHCHLQLEAPQLDVAEPRVSVLEGGEAWLECSLRGGTPPAQLL 589

Query: 613 WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLD--WDLGNYSVLCSGALGAGGDQITL-- 668
           W    +     G S   L  +G +L +G +  D     G Y  +   A+G     + L  
Sbjct: 590 WLGPQQQKVDPGTSGFMLHPEGAQLRLGIYDADPAHHRGTYQCVARNAVGNSSQSVLLEV 649

Query: 669 ----IGPSISSWRLQ--RARDAAVLTWDVERGALISSFEIQ--AWPDGPALGRTSTYRDW 720
                 P+++  RL   R R    L W +     ++ F +Q  A   GP  G   T    
Sbjct: 650 LRYPAPPNVTISRLTYGRHRREVQLQWAILGPGNLTGFLVQRKASALGPGAGAWETAASD 709

Query: 721 VSLLILGPQERSAVVPLPPRNPGT-WTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAG 779
           +      P+ R     L   +PG  + FRIL +     G PS+ ++    P  ++ A+ G
Sbjct: 710 IE-----PESRGR--RLGGLDPGVLYAFRILALNHHTAGHPSEVKIPADPPFSAYPAVLG 762

Query: 780 IVLGSLLGLALLAVLLL 796
              G+ + +A +A LL+
Sbjct: 763 -AAGTGMVVATVASLLV 778


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 143/587 (24%), Positives = 221/587 (37%), Gaps = 104/587 (17%)

Query: 102  QDLSPVSPFSETPGSEVFPDISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDS 161
            +D +PVSP + TPG +VFP                 +   ++  S    ++ ++V A   
Sbjct: 731  KDGNPVSP-AGTPGLQVFPG-------------GRVLTLASARASDSGRYSCVAVSA--- 773

Query: 162  KFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPT 221
                D  D+ L    P              P  +G  L V V     + L    +  PP 
Sbjct: 774  -VGEDRQDVVLQVHMP--------------PSILGEELNVSVVANESVALECQSHAMPPP 818

Query: 222  SLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEV 281
             L  W+ G                 L+P    HL  D+A  +L++  A + DAG YT E 
Sbjct: 819  VLSWWKDGRP---------------LEPRPGVHLSADKA--LLQVDRADVWDAGHYTCEA 861

Query: 282  I-RAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDG 340
            + +AG S++ +   V V    P   ++     T       RL C   G    ++SW +DG
Sbjct: 862  LNQAGHSEKHYNLNVWV---APVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDG 918

Query: 341  RALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPD 400
            + L     EGA    + + G  L + +   +    YTC   +  G+      + V   P 
Sbjct: 919  QPLPG---EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 975

Query: 401  PPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL-ADPAEAAV-----PAGS 454
                 ++  R+      V      TL C A  +PP  +TW     P  A +       G 
Sbjct: 976  -----IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 1030

Query: 455  RLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV-----ADLPPGAPQCSVEGGPGDR 509
             L +      H G Y+C+A N      R+  L++ V      DL P     +    P   
Sbjct: 1031 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP--- 1087

Query: 510  SLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVL-----LAAVPAHPRLSGVPITCLAR 564
             L   C   G  P A   F+G  E +  G  + +L     L       + SG+  +CLA 
Sbjct: 1088 -LTLLCEAMGIPPPAIRWFRG-EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGL-YSCLAS 1144

Query: 565  HLV--ATRTCTVTPEAPREVLLHPLVAETRLGE---------AEVALEASGCPPPSRASW 613
            +    A R  +V      EVL+ P +    L E         A +    +G P P + +W
Sbjct: 1145 NEAGEARRNFSV------EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP-KLTW 1197

Query: 614  AREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
             ++GRPLA G      +S DG  L +   +L    G+YS + + A+G
Sbjct: 1198 FKDGRPLARGDAH--HISPDGVLLQVLQANLS-SAGHYSCIAANAVG 1241



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 123/500 (24%), Positives = 188/500 (37%), Gaps = 77/500 (15%)

Query: 199  LAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFD 258
            +  ++ +++ LP     +P P    V W + S+ L+ G       +  L   H       
Sbjct: 1665 VTAILNSSVSLPCDVHAHPNPE---VTWYKDSQALSLG-----EEVFLLPGTH------- 1709

Query: 259  QARGVLELASAQLDDAGVYTAEVIRA-GVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGA 317
                 L+L  A+L D+G+YT E + A G  Q+  + +V V     Q    P+        
Sbjct: 1710 ----TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1765

Query: 318  AELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYT 377
             +  L C         ++W +DG+ L  A+     T  +R  G +L I     SD   Y+
Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDGQPLVLAQ----RTQALRG-GQRLEIQEAQVSDKGLYS 1820

Query: 378  CRVRSPFGHREAAADVSVFYGP---DPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
            C+V +  G       ++V   P   +P T TVS            AGS + L C  +  P
Sbjct: 1821 CKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ----------VAGSPLVLTCDVSGVP 1870

Query: 435  PADITWSLAD--PAEAA-----VPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLN 487
               +TW L D  P E++     V  G RL L  + P  AGTY C+A N +   R+  ++ 
Sbjct: 1871 APTVTW-LKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVA 1929

Query: 488  LTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPA-ASLQFQGLPEGIRAGP------- 539
            + VA     +           + +R  C   G  P   +    G P G   GP       
Sbjct: 1930 VLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLD 1989

Query: 540  VSSVLLAAVPAHPRLSGVPITCLARHLVA--TRTCTVTPEAPREVLLHPLVAETRLGEAE 597
              S++L  + A         TC+A +      R  TV       VL+ P + +   G   
Sbjct: 1990 GGSLVLKGLRAS---DAGAYTCVAHNPAGEDARLHTV------NVLVPPTIKQGADGSGT 2040

Query: 598  VA-----LEASGCP----PPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDL 648
            +      L    CP    PP   SW ++G PL      R  L   G  L I    L  D 
Sbjct: 2041 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL--SQRTLLHGSGHTLRISKVQLA-DA 2097

Query: 649  GNYSVLCSGALGAGGDQITL 668
            G ++ + +   G      TL
Sbjct: 2098 GIFTCVAASPAGVADRNFTL 2117



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 127/512 (24%), Positives = 192/512 (37%), Gaps = 61/512 (11%)

Query: 173  SAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKV 232
            +A S    F  E H+    P    GP AV V    +  L+P    G P  LV WR+    
Sbjct: 2375 AAGSTSVAFRVEIHTV---PTIRSGPPAVNVSVN-QTALLPCQADGVPAPLVSWRKDRV- 2429

Query: 233  LAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIR-AGVSQQTH 291
                 L P +P   + P            G L +      DAG Y       AG  +Q  
Sbjct: 2430 ----PLDPRSPRFEILP-----------EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGR 2474

Query: 292  EFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGA 351
            +  + V EP P ++  P +  T        L C   G  +  + W +DG+ L+    +GA
Sbjct: 2475 D--LRVLEP-PAIAPSP-SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGA 2530

Query: 352  ETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRD 411
                     + LL+  P   D A++ C V +  G       V+V     PPTI      D
Sbjct: 2531 ---YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIA-----D 2579

Query: 412  AAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSR------LLLPAVGPGH 465
                  VT  + V L C +   P   ++WS A     A  +G R      L +    P H
Sbjct: 2580 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIH 2639

Query: 466  AGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAAS 525
            AG Y C A N      +   + LTV   P   P  SV     +  +   C    G P  +
Sbjct: 2640 AGRYTCSARNSAGVAHKH--VFLTVQASPVVKPLPSVVRAVAEEEVLLPCE-ASGIPRPT 2696

Query: 526  LQFQGLPEGIRAGPVSSVL----LAAVPAHPRLSGVPITCLARH-----LVATRTCTVTP 576
            + +Q     +  G  + VL    L    A P  +G    C+A++     +  TR     P
Sbjct: 2697 ITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAG-NYLCIAKNSAGSAMGKTRLVVQVP 2755

Query: 577  EAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRK 636
                  L  P ++ T    A +  +A G P P+  +W ++G+P++ G   +  +   G +
Sbjct: 2756 PVIENGL--PDLSTTEGSHAFLPCKARGSPEPN-ITWDKDGQPVS-GAEGKFTIQPSG-E 2810

Query: 637  LHIGNFSLDWDLGNYSVLCSGALGAGGDQITL 668
            L + N     D G Y+     A+G    ++ L
Sbjct: 2811 LLVKNLE-GQDAGTYTCTAENAVGRARRRVHL 2841



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 103/424 (24%), Positives = 160/424 (37%), Gaps = 58/424 (13%)

Query: 218 GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
           G PT  V W +  + +  GG                HL+  +   VL +  + + D G Y
Sbjct: 152 GVPTPQVEWTKDRQPVLPGG---------------PHLQVQEDGQVLRITGSHVGDEGRY 196

Query: 278 TAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAEL-RLRCLGWGPGRGELSW 336
              V  +   QQ  +F + V+ P P +    +  E       L +L C   G     ++W
Sbjct: 197 QC-VAFSPAGQQARDFQLRVHAP-PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 254

Query: 337 SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVF 396
            +DG  L  +     +    R  G QL + R   SD   YTC+  +  G  E A  + V+
Sbjct: 255 FKDGALLPTS----TKVVYTRG-GRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309

Query: 397 YGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS-----LADPAEAAVP 451
               PPTI  +  R         AG  V L C A   P   ++W      +A+  E+ + 
Sbjct: 310 V---PPTIEGAGGRPYVVK--AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLE 364

Query: 452 A-GSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGD-- 508
             GS L L + G   +G Y+C+A++P       ++L  +V    P  PQ  V  G G   
Sbjct: 365 TDGSVLRLESPGEASSGLYSCVASSP----AGEAVLQYSVEVQVP--PQLLVAEGLGQVT 418

Query: 509 ----RSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLAR 564
               + L   C    G+P  ++Q+  L  G  A  ++ V +A+      +  V +     
Sbjct: 419 TIVGQPLELPCQ-ASGSPVPTIQW--LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGL 475

Query: 565 HLVATRTCTVTPEAPREVLLH----PLVAETRLGEAEVALE-----ASGCPPPSRASWAR 615
                     T  A  EV +H    P V E  +G+     E      + C PP    W  
Sbjct: 476 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 535

Query: 616 EGRP 619
             +P
Sbjct: 536 HPKP 539



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 156/608 (25%), Positives = 220/608 (36%), Gaps = 103/608 (16%)

Query: 218  GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
            G P   V W +    L A G G       + P+           G LE+  A    AG Y
Sbjct: 2600 GIPAPTVSWSKAGAQLGARGSG-----YRVSPS-----------GALEIGQALPIHAGRY 2643

Query: 278  TAEVIR-AGVSQQTHEFTVG---VYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGE 333
            T      AGV+ +    TV    V +PLP + V+  A E      E+ L C   G  R  
Sbjct: 2644 TCSARNSAGVAHKHVFLTVQASPVVKPLPSV-VRAVAEE------EVLLPCEASGIPRPT 2696

Query: 334  LSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADV 393
            ++W ++G  +    + G  T  +   G QL I      D   Y C  ++  G       +
Sbjct: 2697 ITWQKEGLNV----ATGVSTQVL--PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2750

Query: 394  SVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL-ADPAEAA--- 449
             V     PP I      +  P    T GS+  L C A   P  +ITW     P   A   
Sbjct: 2751 VVQV---PPVI-----ENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGK 2802

Query: 450  --VPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPG 507
              +     LL+  +    AGTY C A N   GR RR  ++LT+  LP           PG
Sbjct: 2803 FTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRR-VHLTILVLPVFTTL------PG 2854

Query: 508  DRSLR------FRCSWPGGAPAASLQF----QGLPEGIRAGPVSSVLLAAVPAHPRLSGV 557
            DRSLR       RC+   G+P   + +    + + EG+      S L  A  A  R    
Sbjct: 2855 DRSLRLGDRLWLRCA-ARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRA--AVSREDSG 2911

Query: 558  PITCLARHLVATRTCTVT----PEAP-REVLLHPLVAETRLGEAEVALEASGCPPPSRAS 612
               C A + V  RT  V+     EAP  +      + E   G  ++     G P P    
Sbjct: 2912 TYVCWAENRVG-RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IH 2969

Query: 613  WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITLIGPS 672
            W ++G PL    GS LR       L I     D D G Y  L    +G     + L+  S
Sbjct: 2970 WIKDGLPLR---GSHLRHQLQNGSLTIRRTERD-DAGRYQCLAENEMGVAKKVVILVLQS 3025

Query: 673  ISSWRLQ------RARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRD---WVSL 723
               ++++      R+ D   L          +   +QA     A  R  T  D   W+  
Sbjct: 3026 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLEN 3085

Query: 724  LILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGIVLG 783
            +  G             + GT+      +LG    T     V R  P  S G++ G++ G
Sbjct: 3086 VETG-------------DAGTYDCVAHNLLGS--ATARAFLVVRGEPQGSWGSMTGVING 3130

Query: 784  SLLGLALL 791
               G+A L
Sbjct: 3131 RKFGVATL 3138



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 121/483 (25%), Positives = 178/483 (36%), Gaps = 66/483 (13%)

Query: 197 GPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLR 256
           G +  +VG  + LP     +P P    +   R ++ LA   +      + +D    DH  
Sbjct: 415 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 474

Query: 257 FDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTH-EFTVGVYE-PLPQLSVQPKAPETE 314
                     A    ++AG   AEV         H E+  GV E P+ Q     +   + 
Sbjct: 475 L--------FACQATNEAGTAGAEV-----EVSVHGEWAPGVLEVPIGQYHWGXEHHSSF 521

Query: 315 EGAAELRLRCLGWG----PGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVR 370
             A +  +   GWG    P   E  W   G    +   E    P   S    L I +   
Sbjct: 522 PAACDPPVH-RGWGAHPKPPLVE-GWCSPG----SLWGEPTGIPVAYSLPPPLQIEKVDL 575

Query: 371 SDHARYTCRVRSPFGH--REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRC 428
            D   YTC   +  G   RE A  V V     PP I       A     V   ++VTL C
Sbjct: 576 RDEGIYTCAATNLAGESKREVALKVLV-----PPNIEPGPVNKA-----VLENASVTLEC 625

Query: 429 AAASRPPADITW-----SLADPAEAAVPAGSRLL-LPAVGPGHAGTYACLAANPRTGRRR 482
            A+  PP D++W      ++      V    R+L +       AG+Y C+A+N       
Sbjct: 626 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685

Query: 483 RSLLNLTV---ADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGP 539
           R  L + V     LPP  P   +   P    +R  C+   GAP+ +L +  L +G    P
Sbjct: 686 RYGLRVNVPPRITLPPSLPGPVLVNTP----VRLTCN-ATGAPSPTLMW--LKDGNPVSP 738

Query: 540 VSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGE---- 595
             +  L   P    L+            +    +   E  ++V+L   +  + LGE    
Sbjct: 739 AGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNV 798

Query: 596 -----AEVALEA-SGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLG 649
                  VALE  S   PP   SW ++GRPL P  G  + LS D   L +    + WD G
Sbjct: 799 SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG--VHLSADKALLQVDRADV-WDAG 855

Query: 650 NYS 652
           +Y+
Sbjct: 856 HYT 858



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 127/485 (26%), Positives = 177/485 (36%), Gaps = 82/485 (16%)

Query: 214  IPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASA---- 269
            I + G PT L +       L     G   P I+    H+D     QA   LE  S     
Sbjct: 2214 IEDSGQPTELSLTPGAPMELLCDAQGTPQPNITW---HKD----GQALTRLENNSRATRV 2266

Query: 270  -QLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAA--ELRLRCLG 326
             ++ DAG+YT  +  +        F V V  P P + V P+ P    G A  +L L C  
Sbjct: 2267 LRVRDAGLYTC-LAESPAGAIEKSFRVRVQAP-PNI-VGPRGPRFVVGLAPGQLVLECSV 2323

Query: 327  WGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGH 386
                  +++W RDG  L+    E A T +    G  L +     +D   Y+C  R+  G 
Sbjct: 2324 EAEPAPKITWHRDGIVLQ----EDAHT-QFPERGRFLQLQALSTADSGDYSCTARNAAGS 2378

Query: 387  REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW------ 440
               A  V +         TV + R   PA  V+      L C A   P   ++W      
Sbjct: 2379 TSVAFRVEIH--------TVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2430

Query: 441  -SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAAN----PRTGRRRRSL---------L 486
                 P    +P GS  + P +    AG Y CLA+N     R GR  R L          
Sbjct: 2431 LDPRSPRFEILPEGSLRIQPVLAQ-DAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2489

Query: 487  NLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLA 546
            NLT+    P    C   G P    +     W  G     L F+      R  P +++LL 
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVV----WWKDG---QKLDFRLQQGAYRLLPSNALLLT 2542

Query: 547  AVPAHPRLSGVPITCLARHLV--ATRTCTVTPEAPREVLLHPLVAE-------TRLGEAE 597
            A             C+  + V  A R   VT   P      P +A+       T +    
Sbjct: 2543 APGPQ---DSAQFECVVSNEVGEAHRLYQVTVHVP------PTIADDQTDFTVTMMAPVV 2593

Query: 598  VALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSG 657
            +   ++G P P+  SW++ G  L    GS  R+S  G  L IG  +L    G Y+  CS 
Sbjct: 2594 LTCHSTGIPAPT-VSWSKAGAQLG-ARGSGYRVSPSG-ALEIGQ-ALPIHAGRYT--CSA 2647

Query: 658  ALGAG 662
               AG
Sbjct: 2648 RNSAG 2652



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 124/491 (25%), Positives = 171/491 (34%), Gaps = 89/491 (18%)

Query: 201  VLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQA 260
            VL G  +RL       P P    V W +    L    +GP             HLRF   
Sbjct: 1947 VLEGQEVRLDCEADGQPPPD---VAWLKDGSPLGQD-MGP-------------HLRFYLD 1989

Query: 261  RGVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAE 319
             G L L   +  DAG YT      AG   + H  TV V  P       P   +  +G+  
Sbjct: 1990 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLH--TVNVLVP-------PTIKQGADGSGT 2040

Query: 320  LRLR--------CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRS 371
            L  R        C   G     +SW +DG  L  ++        +   G  L I +   +
Sbjct: 2041 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT-----LLHGSGHTLRISKVQLA 2095

Query: 372  DHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAA 431
            D   +TC   SP G  +    + V   P    +   +D        V  GS V L C A 
Sbjct: 2096 DAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDV------VVVRGSLVELPCEAR 2149

Query: 432  SRPPADITWSL-ADPA-EAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLT 489
              P   ++W    +P    ++  G  L L AVG G +GTY+C+A +     RR     LT
Sbjct: 2150 GVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLT 2207

Query: 490  VADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVP 549
            V +     P     G P + SL      PG         QG P+           L  + 
Sbjct: 2208 VME----PPHIEDSGQPTELSLT-----PGAPMELLCDAQGTPQPNITWHKDGQALTRLE 2258

Query: 550  AHPRLSGV-------PITCLA-----------RHLVATRTCTVTPEAPREVLLHPLVAET 591
             + R + V         TCLA           R  V      V P  PR V+        
Sbjct: 2259 NNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVV-------- 2310

Query: 592  RLGEAEVALEAS-GCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGN 650
             L   ++ LE S    P  + +W R+G  L     +  +  + GR L +   S   D G+
Sbjct: 2311 GLAPGQLVLECSVEAEPAPKITWHRDGIVLQE--DAHTQFPERGRFLQLQALSTA-DSGD 2367

Query: 651  YSVLCSGALGA 661
            YS     A G+
Sbjct: 2368 YSCTARNAAGS 2378



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 62/243 (25%), Positives = 99/243 (40%), Gaps = 45/243 (18%)

Query: 264  LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELR-- 321
            L++ +AQ +DAG YT  V+   + +    + V V  P    S+    P  E G  E++  
Sbjct: 1315 LQILNAQKEDAGQYTC-VVTNELGEAVKNYHVEVLIPP---SISKDDPLAEVGVKEVKTK 1370

Query: 322  ------LRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGD-QLLIVRPVR-SDH 373
                  L C  W      + W +DG+ +  +        R++  G+ +LL ++P + SD 
Sbjct: 1371 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSS-------RLQVLGEGRLLQIQPTQVSDS 1423

Query: 374  ARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAA---------------PARFV 418
             RY C   +  G  +   +V +     PP      D  AA                 R +
Sbjct: 1424 GRYLCVATNVAGEDDQDFNVLIQV---PPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1480

Query: 419  TAGSNVTLRCAAASRPPADITWSLADPA-----EAAVPAGSRLL-LPAVGPGHAGTYACL 472
               +   L C   + PP D+TW   D       E +V  G R+L +P V   +AG Y+C 
Sbjct: 1481 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1540

Query: 473  AAN 475
            A+N
Sbjct: 1541 ASN 1543



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 110/490 (22%), Positives = 170/490 (34%), Gaps = 78/490 (15%)

Query: 219  PPTSLVVWRRGSKVLAAGGLGPGAPLISLD----PAHRD-HLRFDQARGVLELASAQLDD 273
            PPT + V + G   L     G   P ++ +    P   +  L+       L +  AQ   
Sbjct: 982  PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAH 1041

Query: 274  AGVYTAEVIR-AGVSQQTHEFTV-------GVYEPLPQLSVQPKAPETEEGAAELRLRCL 325
             G Y+      AG +++  E +V       G  +PL  ++    +P        L L C 
Sbjct: 1042 TGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP--------LTLLCE 1093

Query: 326  GWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFG 385
              G     + W R     E   S G +T  + + G  L + +    D   Y+C   +  G
Sbjct: 1094 AMGIPPPAIRWFRG----EEPVSPGEDT-YLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 1148

Query: 386  HREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS---- 441
                   V V     PP+I    + D      V  G    L C     P   +TW     
Sbjct: 1149 EARRNFSVEVLV---PPSI---ENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR 1202

Query: 442  --LADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQ 499
                  A    P G  L +       AG Y+C+AAN    + +   L++ +A    G  +
Sbjct: 1203 PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAE 1262

Query: 500  CSVEGGPGDRSLRFRCSWPGGAPAASLQFQG-----LPEGIRAGPVSSVLLAAVPAHPRL 554
             S      D  +    + P      +L F       + +G       ++ L      P  
Sbjct: 1263 DSA-----DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLL-----PGT 1312

Query: 555  SGVPITCLARHLVATRTCTVTPEAPR-------EVLLHPLVAE----TRLGEAEVALEA- 602
             G+ I    +      TC VT E          EVL+ P +++      +G  EV  +  
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372

Query: 603  --------SGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVL 654
                    S   PP    W ++G+P+ P   SRL++  +GR L I    +  D G Y  L
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGRLLQIQPTQVS-DSGRY--L 1427

Query: 655  CSGALGAGGD 664
            C     AG D
Sbjct: 1428 CVATNVAGED 1437



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 101/430 (23%), Positives = 154/430 (35%), Gaps = 54/430 (12%)

Query: 264 LELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRL 322
           L++    L D G+YT      AG S++  E  + V  P P +   P      E A+ + L
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKR--EVALKVLVP-PNIEPGPVNKAVLENAS-VTL 623

Query: 323 RCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRS 382
            CL  G    ++SW +  + + +             +G  L I +   SD   Y C   +
Sbjct: 624 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-----DGRVLRIEQAQLSDAGSYRCVASN 678

Query: 383 PFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW-- 440
             G  E    + V     PP IT+           V   + V L C A   P   + W  
Sbjct: 679 VAGSTELRYGLRVNV---PPRITLPPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLK 731

Query: 441 ------SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
                     P     P G  L L +     +G Y+C+A +     R+  +L +    +P
Sbjct: 732 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV---HMP 788

Query: 495 PG--APQCSVEGGPGDRSLRFRC-SWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAH 551
           P     + +V     + S+   C S     P  S    G P   R G    V L+A  A 
Sbjct: 789 PSILGEELNVSV-VANESVALECQSHAMPPPVLSWWKDGRPLEPRPG----VHLSADKAL 843

Query: 552 PRLSGVPI------TCLARHLVA------TRTCTVTPEAPREVLLHPLVAETRLGE-AEV 598
            ++    +      TC A +              V P  P   L        R G    +
Sbjct: 844 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP---LRESHTLTVREGHPTRL 900

Query: 599 ALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGA 658
           + E  G P P + SW ++G+PL   G     +S  GR L++G   L  + G Y+  CS  
Sbjct: 901 SCECRGVPFP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE-GTYTCECSNV 958

Query: 659 LGAGGDQITL 668
           +G     + L
Sbjct: 959 VGNSSQDLQL 968



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 87/359 (24%), Positives = 129/359 (35%), Gaps = 52/359 (14%)

Query: 325 LGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPF 384
           LGW     +L W + G              R+  EG  L   R    D   Y+CR  +  
Sbjct: 63  LGWAGYGWDLGWGQVGGH------------RLLDEGQSLHFPRIQEGDSGLYSCRAENQA 110

Query: 385 GHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLAD 444
           G  +    + V     PP++  +    AA      AG++V L+C  +  P   + W+   
Sbjct: 111 GTAQRDFHLLVL---TPPSVLGAG---AAQEVLGLAGADVELQCWTSGVPTPQVEWT--K 162

Query: 445 PAEAAVPAGSRLLLPAVGP---------GHAGTYACLAANPRTGRRRRSLLNLTVADLPP 495
             +  +P G  L +   G          G  G Y C+A +P   + R   L +       
Sbjct: 163 DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW 222

Query: 496 GAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVL-------LAAV 548
           G+ +        D  ++  C    G P  ++ +    +G      + V+       L   
Sbjct: 223 GSNETGEVAVMEDHLVQLLCE-ARGVPTPNITW--FKDGALLPTSTKVVYTRGGRQLQLG 279

Query: 549 PAHPRLSGVPITCLARHLV-----ATRTCTVTPEAPREVLLHPLVAETRLGEAEVALE-- 601
            A    +GV  TC A + V     ATR     P         P V +   G   VALE  
Sbjct: 280 RAQSSDAGV-YTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGR-PVALECV 337

Query: 602 ASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
           A G P P+  SW  EG P+A    S  RL  DG  L + +   +   G YS + S   G
Sbjct: 338 ARGHPSPT-LSWHHEGLPVAESNES--RLETDGSVLRLESPG-EASSGLYSCVASSPAG 392



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 87/395 (22%), Positives = 144/395 (36%), Gaps = 63/395 (15%)

Query: 333  ELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHA-RYTCRVRSPFGHREAAA 391
            +L+W R+ + L A +           +G ++L +  VR+++A RY+C+  +  G      
Sbjct: 1499 DLTWYREDQPLSAGDEVSV------LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 1552

Query: 392  DVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW------SLADP 445
            ++ V      P + +    +      V A S V+L+C A   P   I+W          P
Sbjct: 1553 ELLVL----TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP 1608

Query: 446  AEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPG--------- 496
                +  G  L +       A +Y C+A N      +   L + V     G         
Sbjct: 1609 RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI 1668

Query: 497  -----APQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAH 551
                 +  C V   P      ++ S          Q   L E +   P +  L       
Sbjct: 1669 LNSSVSLPCDVHAHPNPEVTWYKDS----------QALSLGEEVFLLPGTHTLQL---GR 1715

Query: 552  PRLSGVPI-TCLA-----RHLVATRTCTVTPEAPREVLLHPLVAE-TRLGE-AEVALEAS 603
             RLS   + TC A     R     +   + P A R+    P  A   R+G+ A ++ E  
Sbjct: 1716 ARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD 1775

Query: 604  GCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGG 663
              P P+  +W ++G+PL      R +  + G++L I    +  D G YS   S   G   
Sbjct: 1776 ALPEPT-VTWYKDGQPLVL--AQRTQALRGGQRLEIQEAQVS-DKGLYSCKVSNVAGEAV 1831

Query: 664  DQITL---IGPSISSWRLQRARDAA----VLTWDV 691
               TL   + P+  + + +     A    VLT DV
Sbjct: 1832 RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV 1866



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 71/281 (25%), Positives = 106/281 (37%), Gaps = 52/281 (18%)

Query: 420 AGSNVTLRCAAASRPPADITWSLADPAEAAVP---------------AGSRLL------- 457
           AG ++TL C A   P  +I W L D     VP                G RLL       
Sbjct: 32  AGQSLTLECDANGFPVPEIVW-LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLH 90

Query: 458 LPAVGPGHAGTYACLAANPR-TGRRRRSLLNLTVADLPP---GAPQCSVEGGPGDRSLRF 513
            P +  G +G Y+C A N   T +R   LL LT    PP   GA       G     +  
Sbjct: 91  FPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT----PPSVLGAGAAQEVLGLAGADVEL 146

Query: 514 RCSWPGGAPAASLQFQG-----LPEGIRA-----GPVSSVLLAAVPAHPRLSGVPITCLA 563
           +C W  G P   +++       LP G        G V  +  + V    R   V  +   
Sbjct: 147 QC-WTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG 205

Query: 564 RHLVATRTCTVTPEAPREVLLHPLVAETRLGE---AEVALEASGCPPPSRASWAREGRPL 620
           +     R   +   AP  +       E  + E    ++  EA G P P+  +W ++G  L
Sbjct: 206 QQ---ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN-ITWFKDGALL 261

Query: 621 APGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGA 661
                +++  ++ GR+L +G  +   D G Y+   S A+GA
Sbjct: 262 PT--STKVVYTRGGRQLQLGR-AQSSDAGVYTCKASNAVGA 299


>gi|40254891 hypothetical protein FLJ20674 [Homo sapiens]
          Length = 540

 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 75/265 (28%), Positives = 106/265 (40%), Gaps = 16/265 (6%)

Query: 417 FVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLL-----LPAVGPGHAGTYAC 471
           +   GS V   C ++SRPP  + W       ++   G  L      L  + P   G Y C
Sbjct: 142 YAARGSQVDFSCNSSSRPPPVVEWWFQALNSSSESFGHNLTVNFFSLLLISPNLQGNYTC 201

Query: 472 LAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGL 531
           LA N  + R R+    L V   PP APQC  +   G   L+  C W GG P     +   
Sbjct: 202 LALNQLSKRHRKVTTELLVYYPPPSAPQCWAQMASGSFMLQLTCRWDGGYPDPDFLWIEE 261

Query: 532 PEGIRAGPVSSVLLAAVPAHPRLS-GVPITCLARHLVATR---TCTVTPEAPREVLLHPL 587
           P G+  G   S L   + +  +LS G    C+  H+V      +C V    P  +L  P+
Sbjct: 262 PGGVIVG--KSKLGVEMLSESQLSDGKKFKCVTSHIVGPESGASCMVQIRGP-SLLSEPM 318

Query: 588 VAETRLGEAEVALEASGCPPPSRASWARE--GRPLAPGGGSRLRLSQDGRK--LHIGNFS 643
                 G   +  + SG  PP++  W R      +     SR  ++QDG+   L I N S
Sbjct: 319 KTCFTGGNVTLTCQVSGAYPPAKILWLRNLTQPEVIIQPSSRHLITQDGQNSTLTIHNCS 378

Query: 644 LDWDLGNYSVLCSGALGAGGDQITL 668
            D D G Y       +G    +I L
Sbjct: 379 QDLDEGYYICRADSPVGVREMEIWL 403


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 143/610 (23%), Positives = 216/610 (35%), Gaps = 103/610 (16%)

Query: 128  PAKDPKPSFTVKTPASNIST-QVSHTKLSVEAPDSKFSP-DDMDLKLSAQSPESKFSAET 185
            P  + + SFTV  P S  S+ ++    +S++ P S      D   K       +  S E 
Sbjct: 2997 PGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEW 3056

Query: 186  HSAASFPQQ-----VGGPLAVLVGTT----------------IRLPLVPIPNPGPPTSLV 224
             +     +        G +  +VGT                 +   +V +   GPPT  V
Sbjct: 3057 KTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116

Query: 225  -----VWRRGSKVLAAGGLGPGAPL-------ISLDPAHRDHLRFD--QARGVLELASAQ 270
                 VW +  K +    +  G P        IS  PA  +   +    +  VL+++SA+
Sbjct: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK 3176

Query: 271  LDDAGVYTAEVIRA-GVSQQTHEFTV--GVYEP-LPQLSVQPKAPETEEGAAELRLRCLG 326
              DAG Y      A G +Q+  E  V  G   P  PQ+  + +A  T E      LRC  
Sbjct: 3177 PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE-EAELTVEAGHTATLRCSA 3235

Query: 327  WGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGH 386
             G     + WS+    L             R EGD L+I R  + D  +Y C   SP GH
Sbjct: 3236 TGSPAPTIHWSKLRSPLPWQH---------RLEGDTLIIPRVAQQDSGQYICNATSPAGH 3286

Query: 387  REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS-LADP 445
             EA     + +   PP  T   +  +     V AG  V L+C A   PP    WS +   
Sbjct: 3287 AEATI---ILHVESPPYATTVPEHAS-----VQAGETVQLQCLAHGTPPLTFQWSRVGSS 3338

Query: 446  AEAAVPAGSRLL-LPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEG 504
                  A + LL      P  +G Y C   N + G    +   L V   P   P  S+  
Sbjct: 3339 LPGRATARNELLHFERAAPEDSGRYRCRVTN-KVG-SAEAFAQLLVQGPPGSLPATSIPA 3396

Query: 505  GPG--------------DRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPA 550
            G                  S+ F C+ P        Q +   EG +  P  SV    +  
Sbjct: 3397 GSTPTVQVTPQLETKSIGASVEFHCAVPSD---RGTQLRWFKEGGQLPPGHSVQDGVL-- 3451

Query: 551  HPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPL----------VAETRLGEA-EVA 599
              R+  +  +C   ++          +A  ++++  L          V    +G A E  
Sbjct: 3452 --RIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFE 3509

Query: 600  LEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGAL 659
              A G P P + +W++ G  L PG      + Q G  + I +  L  D G Y    + A 
Sbjct: 3510 CLALGDPKP-QVTWSKVGGHLRPG------IVQSGGVVRIAHVELA-DAGQYRCTATNAA 3561

Query: 660  GAGGDQITLI 669
            G     + L+
Sbjct: 3562 GTTQSHVLLL 3571



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 78/274 (28%), Positives = 111/274 (40%), Gaps = 28/274 (10%)

Query: 262  GVLELASAQLDDAGVYTAEVIRA-GVSQQTHEFTVGVYEPL--PQLSVQPKAPETEEGAA 318
            G+L + + QL DAG Y         + Q T    V     L  P +S+ P     + G  
Sbjct: 1823 GILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQL 1882

Query: 319  ELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETP-RMRSEGDQLLIVRPVRSDHARYT 377
                RC   G     L W+            G + P + +  G  L +     +D A+Y 
Sbjct: 1883 -AEFRCSATGSPTPTLEWT---------GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYL 1932

Query: 378  CRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPAD 437
            CR  S  G + A A + V +G   P + VS +R       V AG  V L C AA  P A 
Sbjct: 1933 CRAHSSAGQQVARAVLHV-HGGGGPRVQVSPERTQ-----VHAGRTVRLYCRAAGVPSAT 1986

Query: 438  ITW-----SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPR-TGRRRRSLLNLTVA 491
            ITW     SL   A +     + LL+PA+    AG Y C+A +P  T + R  ++ L+ +
Sbjct: 1987 ITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSAS 2046

Query: 492  DL--PPGAPQCSVEGGPGDRSLRFRCSWPGGAPA 523
            D   PP   + S       ++L   C   G A A
Sbjct: 2047 DASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 91/368 (24%), Positives = 135/368 (36%), Gaps = 69/368 (18%)

Query: 170  LKLSAQSP--ESKFSAETHSAASFPQQV----------GGPLA--------VLVGTTIRL 209
            L+L A  P  ++++    HS+A   QQV          GGP          V  G T+RL
Sbjct: 1918 LRLPAVEPTDQAQYLCRAHSSAG--QQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRL 1975

Query: 210  PLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASA 269
                    G P++ + WR+       GG        SL P  R   R D A   L + + 
Sbjct: 1976 YCRAA---GVPSATITWRK------EGG--------SLPPQARSE-RTDIA--TLLIPAI 2015

Query: 270  QLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPL--PQLSVQPKAPETEEGAAELRLRCLG 326
               DAG Y       AG +Q   +  V        P + ++  +P   EG   L L C+ 
Sbjct: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQT-LDLNCVV 2074

Query: 327  WGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGH 386
             G    +++W R G         G+  P  +  G +L + +   +D   Y CRV +  G 
Sbjct: 2075 AGSAHAQVTWYRRG---------GSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGP 2125

Query: 387  REAAADVSVFYGPDPPTITVSSDRDAAPARF------VTAGSNVTLRCAAASRPPADITW 440
            +EA+  VSV +G               P R       V  G  + L C    +  A +TW
Sbjct: 2126 KEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTW 2185

Query: 441  SLADPAEAAVPA-----GSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP 495
                    ++PA     GS L L  V P  +G Y C             L+ +  + +P 
Sbjct: 2186 ---HKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPG 2242

Query: 496  GAPQCSVE 503
              P   +E
Sbjct: 2243 PIPPVRIE 2250



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 67/254 (26%), Positives = 104/254 (40%), Gaps = 32/254 (12%)

Query: 246  SLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEF-TVGVYEPLPQL 304
            SL   H+ H        +L L  A   D+G Y   V+ + V  +     T+     +P L
Sbjct: 2380 SLPVRHQTH------GSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPAL 2433

Query: 305  SVQP------KAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRS 358
             V P       + +  EG   L L CL  G    +++W + G +L A         R + 
Sbjct: 2434 GVTPTVRIESSSSQVAEGQT-LDLNCLVAGQAHAQVTWHKRGGSLPA---------RHQV 2483

Query: 359  EGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSV---FYGPDPPTITVSSDRDAAPA 415
             G +L +++   +D   Y CRV    G +EA+  V++     G     +      +++ A
Sbjct: 2484 HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 2543

Query: 416  RFVTAGSNVTLRCAAASRPPADITWSLAD---PAEAAVPAGSRLLLPAVGPGHAGTYACL 472
                 G  + L C  AS+ P  ITW       P+   +  GSRL +P V P  +G Y C 
Sbjct: 2544 SLAN-GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI-VGSRLRIPQVTPADSGEYVCH 2601

Query: 473  AANPRTGRRRRSLL 486
             +N   G R  SL+
Sbjct: 2602 VSN-GAGSRETSLI 2614



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 64/232 (27%), Positives = 89/232 (38%), Gaps = 38/232 (16%)

Query: 264  LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGV---------YEPLP----QLSVQPKA 310
            L L      D+G Y   V   G   +    TV V         Y P+P     + ++P +
Sbjct: 2102 LRLPQVSPADSGEYVCRV-ENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS 2160

Query: 311  PETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVR 370
                EG   L L C+  G    +++W + G +L A         R ++ G  L + +   
Sbjct: 2161 SHVAEGQT-LDLNCVVPGQAHAQVTWHKRGGSLPA---------RHQTHGSLLRLHQVTP 2210

Query: 371  SDHARYTCRVRSPFGHREAAA----DVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTL 426
            +D   Y C V    G  EA+     + SV  GP PP    SS    A       G  + L
Sbjct: 2211 ADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAE------GQTLDL 2264

Query: 427  RCAAASRPPADITWSLAD---PAEAAVPAGSRLLLPAVGPGHAGTYACLAAN 475
             C  A +  A +TW       PA   V  GSRL +    P  AG Y C A+N
Sbjct: 2265 SCVVAGQAHAQVTWYKRGGSLPARHQV-RGSRLYIFQASPADAGQYVCRASN 2315



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 101/449 (22%), Positives = 159/449 (35%), Gaps = 64/449 (14%)

Query: 273  DAGVYTAEVIRAGVSQQTHEFTV-------GVYEPLPQLSVQPKAPETEEGAAELRLRCL 325
            D+G Y   V     S++T             V    P + ++  +P   EG   L L C+
Sbjct: 2594 DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQT-LDLNCV 2652

Query: 326  GWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFG 385
                 +  ++W + G +L +         R ++ G  L + +   +D   Y CR  +   
Sbjct: 2653 VARQPQAIITWYKRGGSLPS---------RHQTHGSHLRLHQMSVADSGEYVCRANNNID 2703

Query: 386  HREAAADVSVFYGPDPPTITVSSD--RDAAPARFVTAGSNVTLRCAAASRPPADITWSLA 443
              EA+  +SV      P+   SS   R  + +  V  G  + L C    +  A +TW   
Sbjct: 2704 ALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKR 2763

Query: 444  DPAEAAVPA-----GSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVA------- 491
                 ++P+     GSRL L  V P  +G Y C             L+ +  +       
Sbjct: 2764 G---GSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHV 2820

Query: 492  DLPPGAPQCSVEGGPG----DRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAA 547
              P GAP   +E         ++L  +C  PG A A     +          V   LL  
Sbjct: 2821 PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRL 2880

Query: 548  VPAHPRLSG---VPITCLARHLVATRTCTVTPEAPREV----LLHPLVAETRLGE-AEVA 599
                P  SG     +T  +  L A+   T+ P +P  +    L  P+  E       E  
Sbjct: 2881 NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ 2940

Query: 600  LEASGCPPPSRA----SWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLC 655
                 C  P +A    +W +       GG    R    G +L +   S   D G Y  +C
Sbjct: 2941 TLDLNCVVPGQAHAQVTWYKR------GGSLPARHQTHGSQLRLHLVS-PADSGEY--VC 2991

Query: 656  SGALGAGGDQ-----ITLIGPSISSWRLQ 679
              A G G +Q     +T+     SS+RL+
Sbjct: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLR 3020



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 54/221 (24%), Positives = 89/221 (40%), Gaps = 31/221 (14%)

Query: 262  GVLELASAQLDDAGVYTAEVIRA-GVSQQTHEFTVGVYEPLPQLSVQPKAP-ETEEGAAE 319
            GVL + +      G Y  +     G +Q + +  +   + LP + +  +   +T      
Sbjct: 3449 GVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI---QALPSVLINIRTSVQTVVVGHA 3505

Query: 320  LRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCR 379
            +   CL  G  + +++WS+ G  L          P +   G  + I     +D  +Y C 
Sbjct: 3506 VEFECLALGDPKPQVTWSKVGGHLR---------PGIVQSGGVVRIAHVELADAGQYRCT 3556

Query: 380  VRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADIT 439
              +  G  ++   + V   P      +S  ++      V AGS     C A+  P  DI+
Sbjct: 3557 ATNAAGTTQSHVLLLVQALPQ-----ISMPQEVR----VPAGSAAVFPCIASGYPTPDIS 3607

Query: 440  WSLADPAEAAVPAGSRL-----LLPAVGPGHAGTYACLAAN 475
            WS  D    ++P  SRL     +LP+V P  AGTY C A N
Sbjct: 3608 WSKLD---GSLPPDSRLENNMLMLPSVRPQDAGTYVCTATN 3645



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 90/402 (22%), Positives = 153/402 (38%), Gaps = 70/402 (17%)

Query: 263  VLELASAQLDDAGVYTAEVI-RAGVSQQTHEFTVGVYEPLP--------QLSVQPKAPET 313
            +L L      D+G Y+ +V   +G  + +   T+    P P         + ++  +   
Sbjct: 2877 LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV 2936

Query: 314  EEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDH 373
             EG   L L C+  G    +++W + G +L A         R ++ G QL +     +D 
Sbjct: 2937 TEGQT-LDLNCVVPGQAHAQVTWYKRGGSLPA---------RHQTHGSQLRLHLVSPADS 2986

Query: 374  ARYTCRVRS-PFGHREAAADVSV------FYGPDPPTITVSSDRDAAPARFVTAGSNVTL 426
              Y CR  S P   +EA+  V+V       Y    P I++       P+  V  G + + 
Sbjct: 2987 GEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDP-----PSSTVQQGQDASF 3041

Query: 427  RCAAAS-RPPADITWS-----LADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGR 480
            +C       P  + W      L D    + P GS + +    P + GTY C+A+N     
Sbjct: 3042 KCLIHDGAAPISLEWKTRNQELEDNVHIS-PNGSIITIVGTRPSNHGTYRCVASN--AYG 3098

Query: 481  RRRSLLNL------TVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQF---QGL 531
              +S++NL      TV+ LP G     V      +++   C    G P +S ++      
Sbjct: 3099 VAQSVVNLSVHGPPTVSVLPEGPVWVKV-----GKAVTLECV-SAGEPRSSARWTRISST 3152

Query: 532  PEGIRAGPV----SSVLLAAVPAHPRLSGVPITCLARHLVATR---------TCTVTPEA 578
            P  +         S  +L    A P  +G  + CLA++ + T          T  + P A
Sbjct: 3153 PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYV-CLAQNALGTAQKQVEVIVDTGAMAPGA 3211

Query: 579  PREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPL 620
            P+       +       A +   A+G P P+   W++   PL
Sbjct: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPT-IHWSKLRSPL 3252



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 46/189 (24%), Positives = 76/189 (40%), Gaps = 18/189 (9%)

Query: 320  LRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCR 379
            L L CL        ++W + G +L +         R +  G +L I +   +D   Y C 
Sbjct: 2551 LDLNCLVASQAPHTITWYKRGGSLPS---------RHQIVGSRLRIPQVTPADSGEYVCH 2601

Query: 380  VRSPFGHREAAADVSVFYGPDPPTITVSSD-RDAAPARFVTAGSNVTLRCAAASRPPADI 438
            V +  G RE +  V++         +VS   R  + +  V  G  + L C  A +P A I
Sbjct: 2602 VSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAII 2661

Query: 439  TWSLADPAEAAVPA-----GSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADL 493
            TW        ++P+     GS L L  +    +G Y C A N         +++++ +  
Sbjct: 2662 TWY---KRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAG 2718

Query: 494  PPGAPQCSV 502
             P AP  S+
Sbjct: 2719 SPSAPGSSM 2727



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 60/218 (27%), Positives = 83/218 (38%), Gaps = 26/218 (11%)

Query: 414  PAR-FVTAGSNVTLRCAAASRPPADITWSLAD--PAEAAVPA---GSRLLLPAVGPGHAG 467
            PAR  V  G + +LRC  +  PP    WS  D  P  +       GS L  P+V P  AG
Sbjct: 1683 PARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAG 1742

Query: 468  TYACLAANPRTGRRRRSLLNLTVADLPP----GAPQCSVEGGPGDRSLRFRCSWPGGAPA 523
             Y C   N       R+ L +T A   P       Q S    PG   + F C+    +PA
Sbjct: 1743 VYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPG-ADVTFICTAKSKSPA 1801

Query: 524  ASLQFQGLPEG---IRAGPVSSVLLAAVPAHPRLSGV-PITCLARHLVATRTCTVTPEAP 579
             +L +  L  G    RA   + +L      + +LS      C   ++ A    T T    
Sbjct: 1802 YTLVWTRLHNGKLPTRAMDFNGILTI---RNVQLSDAGTYVCTGSNMFAMDQGTATLHVQ 1858

Query: 580  RE-------VLLHPLVAETRLGE-AEVALEASGCPPPS 609
                     V +HP     + G+ AE    A+G P P+
Sbjct: 1859 ASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPT 1896



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 70/311 (22%), Positives = 108/311 (34%), Gaps = 65/311 (20%)

Query: 185  THSAASFPQQVGGPLAVLV---------GTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAA 235
            THS  S+    G    + +         G T+ L  V    PG   + V W +       
Sbjct: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVV---PGQAHAQVTWHK------R 2188

Query: 236  GGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTV 295
            GG        SL   H+ H        +L L      D+G Y   V+  G S       +
Sbjct: 2189 GG--------SLPARHQTH------GSLLRLHQVTPADSGEYVCHVV--GTSGPLEASVL 2232

Query: 296  GVYE------PLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESE 349
               E      P+P + ++  +    EG   L L C+  G    +++W + G +L A    
Sbjct: 2233 VTIEASVIPGPIPPVRIESSSSTVAEGQT-LDLSCVVAGQAHAQVTWYKRGGSLPA---- 2287

Query: 350  GAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDP----PTIT 405
                 R +  G +L I +   +D  +Y CR  +     EA+  V+V          P  +
Sbjct: 2288 -----RHQVRGSRLYIFQASPADAGQYVCRASNGM---EASITVTVTGTQGANLAYPAGS 2339

Query: 406  VSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPA-----GSRLLLPA 460
                R    +  V  G  + L C    +  A +TW        ++P      GS L L  
Sbjct: 2340 TQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTW---HKRGGSLPVRHQTHGSLLRLYQ 2396

Query: 461  VGPGHAGTYAC 471
              P  +G Y C
Sbjct: 2397 ASPADSGEYVC 2407



 Score = 30.8 bits (68), Expect = 5.7
 Identities = 28/94 (29%), Positives = 37/94 (39%), Gaps = 12/94 (12%)

Query: 392 DVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL------ADP 445
           D S  +G  PP + V+  R++  A   + G  VT  C A   P   I W L      + P
Sbjct: 396 DRSDEFGCMPPQV-VTPPRESIQA---SRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHP 451

Query: 446 AEAAVPAGSR--LLLPAVGPGHAGTYACLAANPR 477
                  G R  L++  V     G Y C A N R
Sbjct: 452 RVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNAR 485


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 142/587 (24%), Positives = 220/587 (37%), Gaps = 104/587 (17%)

Query: 102  QDLSPVSPFSETPGSEVFPDISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDS 161
            +D +PVSP + TPG +VFP                 +   ++  S    ++ ++V A   
Sbjct: 822  KDGNPVSP-AGTPGLQVFPG-------------GRVLTLASARASDSGRYSCVAVSA--- 864

Query: 162  KFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPT 221
                D  D+ L    P              P  +G  L V V     + L    +  PP 
Sbjct: 865  -VGEDRQDVVLQVHMP--------------PSILGEELNVSVVANESVALECQSHAMPPP 909

Query: 222  SLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEV 281
             L  W+ G                 L+P    HL  D+A  +L++  A + DAG YT E 
Sbjct: 910  VLSWWKDGRP---------------LEPRPGVHLSADKA--LLQVDRADVWDAGHYTCEA 952

Query: 282  I-RAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDG 340
            + +AG S++ +   V V    P   ++     T        L C   G    ++SW +DG
Sbjct: 953  LNQAGRSEKHYNLNVWV---APVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDG 1009

Query: 341  RALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPD 400
            + L     EGA    + + G  L + +   +    YTC   +  G+      + V   P 
Sbjct: 1010 QPLPG---EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 1066

Query: 401  PPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL-ADPAEAAV-----PAGS 454
                 ++  R+      V      TL C A  +PP  +TW     P  A +       G 
Sbjct: 1067 -----IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 1121

Query: 455  RLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV-----ADLPPGAPQCSVEGGPGDR 509
             L +      H G Y+C+A N      R+  L++ V      DL P     +    P   
Sbjct: 1122 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP--- 1178

Query: 510  SLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVL-----LAAVPAHPRLSGVPITCLAR 564
             L   C   G  P A   F+G  E +  G  + +L     L       + SG+  +CLA 
Sbjct: 1179 -LTLLCEAMGIPPPAIRWFRG-EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGL-YSCLAS 1235

Query: 565  HLV--ATRTCTVTPEAPREVLLHPLVAETRLGE---------AEVALEASGCPPPSRASW 613
            +    A R  +V      EVL+ P +    L E         A +    +G P P + +W
Sbjct: 1236 NEAGEARRNFSV------EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP-KLTW 1288

Query: 614  AREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
             ++GRPLA G      +S DG  L +   +L    G+YS + + A+G
Sbjct: 1289 FKDGRPLARGDAH--HISPDGVLLQVLQANLS-SAGHYSCIAANAVG 1332



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 123/500 (24%), Positives = 188/500 (37%), Gaps = 77/500 (15%)

Query: 199  LAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFD 258
            +  ++ +++ LP     +P P    V W + S+ L+ G       +  L   H       
Sbjct: 1756 VTAILNSSVSLPCDVHAHPNPE---VTWYKDSQALSLG-----EEVFLLPGTH------- 1800

Query: 259  QARGVLELASAQLDDAGVYTAEVIRA-GVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGA 317
                 L+L  A+L D+G+YT E + A G  Q+  + +V V     Q    P+        
Sbjct: 1801 ----TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1856

Query: 318  AELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYT 377
             +  L C         ++W +DG+ L  A+     T  +R  G +L I     SD   Y+
Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDGQPLVLAQ----RTQALRG-GQRLEIQEAQVSDKGLYS 1911

Query: 378  CRVRSPFGHREAAADVSVFYGP---DPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
            C+V +  G       ++V   P   +P T TVS            AGS + L C  +  P
Sbjct: 1912 CKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ----------VAGSPLVLTCDVSGVP 1961

Query: 435  PADITWSLAD--PAEAA-----VPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLN 487
               +TW L D  P E++     V  G RL L  + P  AGTY C+A N +   R+  ++ 
Sbjct: 1962 APTVTW-LKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVA 2020

Query: 488  LTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPA-ASLQFQGLPEGIRAGP------- 539
            + VA     +           + +R  C   G  P   +    G P G   GP       
Sbjct: 2021 VLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLD 2080

Query: 540  VSSVLLAAVPAHPRLSGVPITCLARHLVA--TRTCTVTPEAPREVLLHPLVAETRLGEAE 597
              S++L  + A         TC+A +      R  TV       VL+ P + +   G   
Sbjct: 2081 GGSLVLKGLRAS---DAGAYTCVAHNPAGEDARLHTV------NVLVPPTIKQGADGSGT 2131

Query: 598  VA-----LEASGCP----PPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDL 648
            +      L    CP    PP   SW ++G PL      R  L   G  L I    L  D 
Sbjct: 2132 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL--SQRTLLHGSGHTLRISKVQLA-DA 2188

Query: 649  GNYSVLCSGALGAGGDQITL 668
            G ++ + +   G      TL
Sbjct: 2189 GIFTCVAASPAGVADRNFTL 2208



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 127/512 (24%), Positives = 192/512 (37%), Gaps = 61/512 (11%)

Query: 173  SAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKV 232
            +A S    F  E H+    P    GP AV V    +  L+P    G P  LV WR+    
Sbjct: 2466 AAGSTSVAFRVEIHTV---PTIRSGPPAVNVSVN-QTALLPCQADGVPAPLVSWRKDRV- 2520

Query: 233  LAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIR-AGVSQQTH 291
                 L P +P   + P            G L +      DAG Y       AG  +Q  
Sbjct: 2521 ----PLDPRSPRFEILP-----------EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGR 2565

Query: 292  EFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGA 351
            +  + V EP P ++  P +  T        L C   G  +  + W +DG+ L+    +GA
Sbjct: 2566 D--LRVLEP-PAIAPSP-SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGA 2621

Query: 352  ETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRD 411
                     + LL+  P   D A++ C V +  G       V+V     PPTI      D
Sbjct: 2622 ---YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIA-----D 2670

Query: 412  AAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSR------LLLPAVGPGH 465
                  VT  + V L C +   P   ++WS A     A  +G R      L +    P H
Sbjct: 2671 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIH 2730

Query: 466  AGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAAS 525
            AG Y C A N      +   + LTV   P   P  SV     +  +   C    G P  +
Sbjct: 2731 AGRYTCSARNSAGVAHKH--VFLTVQASPVVKPLPSVVRAVAEEEVLLPCE-ASGIPRPT 2787

Query: 526  LQFQGLPEGIRAGPVSSVL----LAAVPAHPRLSGVPITCLARH-----LVATRTCTVTP 576
            + +Q     +  G  + VL    L    A P  +G    C+A++     +  TR     P
Sbjct: 2788 ITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAG-NYLCIAKNSAGSAMGKTRLVVQVP 2846

Query: 577  EAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRK 636
                  L  P ++ T    A +  +A G P P+  +W ++G+P++ G   +  +   G +
Sbjct: 2847 PVIENGL--PDLSTTEGSHAFLPCKARGSPEPN-ITWDKDGQPVS-GAEGKFTIQPSG-E 2901

Query: 637  LHIGNFSLDWDLGNYSVLCSGALGAGGDQITL 668
            L + N     D G Y+     A+G    ++ L
Sbjct: 2902 LLVKNLE-GQDAGTYTCTAENAVGRARRRVHL 2932



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 103/424 (24%), Positives = 160/424 (37%), Gaps = 58/424 (13%)

Query: 218 GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
           G PT  V W +  + +  GG                HL+  +   VL +  + + D G Y
Sbjct: 243 GVPTPQVEWTKDRQPVLPGG---------------PHLQVQEDGQVLRITGSHVGDEGRY 287

Query: 278 TAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAEL-RLRCLGWGPGRGELSW 336
              V  +   QQ  +F + V+ P P +    +  E       L +L C   G     ++W
Sbjct: 288 QC-VAFSPAGQQARDFQLRVHAP-PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 345

Query: 337 SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVF 396
            +DG  L  +     +    R  G QL + R   SD   YTC+  +  G  E A  + V+
Sbjct: 346 FKDGALLPTS----TKVVYTRG-GRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 400

Query: 397 YGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS-----LADPAEAAVP 451
               PPTI  +  R         AG  V L C A   P   ++W      +A+  E+ + 
Sbjct: 401 V---PPTIEGAGGRPYVVK--AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLE 455

Query: 452 A-GSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGD-- 508
             GS L L + G   +G Y+C+A++P       ++L  +V    P  PQ  V  G G   
Sbjct: 456 TDGSVLRLESPGEASSGLYSCVASSP----AGEAVLQYSVEVQVP--PQLLVAEGLGQVT 509

Query: 509 ----RSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLAR 564
               + L   C    G+P  ++Q+  L  G  A  ++ V +A+      +  V +     
Sbjct: 510 TIVGQPLELPCQ-ASGSPVPTIQW--LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGL 566

Query: 565 HLVATRTCTVTPEAPREVLLH----PLVAETRLGEAEVALE-----ASGCPPPSRASWAR 615
                     T  A  EV +H    P V E  +G+     E      + C PP    W  
Sbjct: 567 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 626

Query: 616 EGRP 619
             +P
Sbjct: 627 HPKP 630



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 156/608 (25%), Positives = 220/608 (36%), Gaps = 103/608 (16%)

Query: 218  GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
            G P   V W +    L A G G       + P+           G LE+  A    AG Y
Sbjct: 2691 GIPAPTVSWSKAGAQLGARGSG-----YRVSPS-----------GALEIGQALPIHAGRY 2734

Query: 278  TAEVIR-AGVSQQTHEFTVG---VYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGE 333
            T      AGV+ +    TV    V +PLP + V+  A E      E+ L C   G  R  
Sbjct: 2735 TCSARNSAGVAHKHVFLTVQASPVVKPLPSV-VRAVAEE------EVLLPCEASGIPRPT 2787

Query: 334  LSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADV 393
            ++W ++G  +    + G  T  +   G QL I      D   Y C  ++  G       +
Sbjct: 2788 ITWQKEGLNV----ATGVSTQVL--PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 2841

Query: 394  SVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL-ADPAEAA--- 449
             V     PP I      +  P    T GS+  L C A   P  +ITW     P   A   
Sbjct: 2842 VVQV---PPVI-----ENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGK 2893

Query: 450  --VPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPG 507
              +     LL+  +    AGTY C A N   GR RR  ++LT+  LP           PG
Sbjct: 2894 FTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRR-VHLTILVLPVFTTL------PG 2945

Query: 508  DRSLR------FRCSWPGGAPAASLQF----QGLPEGIRAGPVSSVLLAAVPAHPRLSGV 557
            DRSLR       RC+   G+P   + +    + + EG+      S L  A  A  R    
Sbjct: 2946 DRSLRLGDRLWLRCA-ARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRA--AVSREDSG 3002

Query: 558  PITCLARHLVATRTCTVT----PEAP-REVLLHPLVAETRLGEAEVALEASGCPPPSRAS 612
               C A + V  RT  V+     EAP  +      + E   G  ++     G P P    
Sbjct: 3003 TYVCWAENRVG-RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IH 3060

Query: 613  WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITLIGPS 672
            W ++G PL    GS LR       L I     D D G Y  L    +G     + L+  S
Sbjct: 3061 WIKDGLPLR---GSHLRHQLQNGSLTIHRTERD-DAGRYQCLAENEMGVAKKVVILVLQS 3116

Query: 673  ISSWRLQ------RARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRD---WVSL 723
               ++++      R+ D   L          +   +QA     A  R  T  D   W+  
Sbjct: 3117 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLEN 3176

Query: 724  LILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGIVLG 783
            +  G             + GT+      +LG    T     V R  P  S G++ G++ G
Sbjct: 3177 VETG-------------DAGTYDCVAHNLLGS--ATARAFLVVRGEPQGSWGSMTGVING 3221

Query: 784  SLLGLALL 791
               G+A L
Sbjct: 3222 RKFGVATL 3229



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 121/483 (25%), Positives = 178/483 (36%), Gaps = 66/483 (13%)

Query: 197 GPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLR 256
           G +  +VG  + LP     +P P    +   R ++ LA   +      + +D    DH  
Sbjct: 506 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 565

Query: 257 FDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTH-EFTVGVYE-PLPQLSVQPKAPETE 314
                     A    ++AG   AEV         H E+  GV E P+ Q     +   + 
Sbjct: 566 L--------FACQATNEAGTAGAEV-----EVSVHGEWAPGVLEVPIGQYHWGXEHHSSF 612

Query: 315 EGAAELRLRCLGWG----PGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVR 370
             A +  +   GWG    P   E  W   G    +   E    P   S    L I +   
Sbjct: 613 PAACDPPVH-RGWGAHPKPPLVE-GWCSPG----SLWGEPTGIPVAYSLPPPLQIEKVDL 666

Query: 371 SDHARYTCRVRSPFGH--REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRC 428
            D   YTC   +  G   RE A  V V     PP I       A     V   ++VTL C
Sbjct: 667 RDEGIYTCAATNLAGESKREVALKVLV-----PPNIEPGPVNKA-----VLENASVTLEC 716

Query: 429 AAASRPPADITW-----SLADPAEAAVPAGSRLL-LPAVGPGHAGTYACLAANPRTGRRR 482
            A+  PP D++W      ++      V    R+L +       AG+Y C+A+N       
Sbjct: 717 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776

Query: 483 RSLLNLTV---ADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGP 539
           R  L + V     LPP  P   +   P    +R  C+   GAP+ +L +  L +G    P
Sbjct: 777 RYGLRVNVPPRITLPPSLPGPVLVNTP----VRLTCN-ATGAPSPTLMW--LKDGNPVSP 829

Query: 540 VSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGE---- 595
             +  L   P    L+            +    +   E  ++V+L   +  + LGE    
Sbjct: 830 AGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNV 889

Query: 596 -----AEVALEA-SGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLG 649
                  VALE  S   PP   SW ++GRPL P  G  + LS D   L +    + WD G
Sbjct: 890 SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG--VHLSADKALLQVDRADV-WDAG 946

Query: 650 NYS 652
           +Y+
Sbjct: 947 HYT 949



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 127/485 (26%), Positives = 177/485 (36%), Gaps = 82/485 (16%)

Query: 214  IPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASA---- 269
            I + G PT L +       L     G   P I+    H+D     QA   LE  S     
Sbjct: 2305 IEDSGQPTELSLTPGAPMELLCDAQGTPQPNITW---HKD----GQALTRLENNSRATRV 2357

Query: 270  -QLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAA--ELRLRCLG 326
             ++ DAG+YT  +  +        F V V  P P + V P+ P    G A  +L L C  
Sbjct: 2358 LRVRDAGLYTC-LAESPAGAIEKSFRVRVQAP-PNI-VGPRGPRFVVGLAPGQLVLECSV 2414

Query: 327  WGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGH 386
                  +++W RDG  L+    E A T +    G  L +     +D   Y+C  R+  G 
Sbjct: 2415 EAEPAPKITWHRDGIVLQ----EDAHT-QFPERGRFLQLQALSTADSGDYSCTARNAAGS 2469

Query: 387  REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW------ 440
               A  V +         TV + R   PA  V+      L C A   P   ++W      
Sbjct: 2470 TSVAFRVEIH--------TVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2521

Query: 441  -SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAAN----PRTGRRRRSL---------L 486
                 P    +P GS  + P +    AG Y CLA+N     R GR  R L          
Sbjct: 2522 LDPRSPRFEILPEGSLRIQPVLAQ-DAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2580

Query: 487  NLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLA 546
            NLT+    P    C   G P    +     W  G     L F+      R  P +++LL 
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVV----WWKDG---QKLDFRLQQGAYRLLPSNALLLT 2633

Query: 547  AVPAHPRLSGVPITCLARHLV--ATRTCTVTPEAPREVLLHPLVAE-------TRLGEAE 597
            A             C+  + V  A R   VT   P      P +A+       T +    
Sbjct: 2634 APGPQ---DSAQFECVVSNEVGEAHRLYQVTVHVP------PTIADDQTDFTVTMMAPVV 2684

Query: 598  VALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSG 657
            +   ++G P P+  SW++ G  L    GS  R+S  G  L IG  +L    G Y+  CS 
Sbjct: 2685 LTCHSTGIPAPT-VSWSKAGAQLG-ARGSGYRVSPSG-ALEIGQ-ALPIHAGRYT--CSA 2738

Query: 658  ALGAG 662
               AG
Sbjct: 2739 RNSAG 2743



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 124/491 (25%), Positives = 171/491 (34%), Gaps = 89/491 (18%)

Query: 201  VLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQA 260
            VL G  +RL       P P    V W +    L    +GP             HLRF   
Sbjct: 2038 VLEGQEVRLDCEADGQPPPD---VAWLKDGSPLGQD-MGP-------------HLRFYLD 2080

Query: 261  RGVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAE 319
             G L L   +  DAG YT      AG   + H  TV V  P       P   +  +G+  
Sbjct: 2081 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLH--TVNVLVP-------PTIKQGADGSGT 2131

Query: 320  LRLR--------CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRS 371
            L  R        C   G     +SW +DG  L  ++        +   G  L I +   +
Sbjct: 2132 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT-----LLHGSGHTLRISKVQLA 2186

Query: 372  DHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAA 431
            D   +TC   SP G  +    + V   P    +   +D        V  GS V L C A 
Sbjct: 2187 DAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDV------VVVRGSLVELPCEAR 2240

Query: 432  SRPPADITWSL-ADPA-EAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLT 489
              P   ++W    +P    ++  G  L L AVG G +GTY+C+A +     RR     LT
Sbjct: 2241 GVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLT 2298

Query: 490  VADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVP 549
            V +     P     G P + SL      PG         QG P+           L  + 
Sbjct: 2299 VME----PPHIEDSGQPTELSLT-----PGAPMELLCDAQGTPQPNITWHKDGQALTRLE 2349

Query: 550  AHPRLSGV-------PITCLA-----------RHLVATRTCTVTPEAPREVLLHPLVAET 591
             + R + V         TCLA           R  V      V P  PR V+        
Sbjct: 2350 NNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVV-------- 2401

Query: 592  RLGEAEVALEAS-GCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGN 650
             L   ++ LE S    P  + +W R+G  L     +  +  + GR L +   S   D G+
Sbjct: 2402 GLAPGQLVLECSVEAEPAPKITWHRDGIVLQE--DAHTQFPERGRFLQLQALSTA-DSGD 2458

Query: 651  YSVLCSGALGA 661
            YS     A G+
Sbjct: 2459 YSCTARNAAGS 2469



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 62/243 (25%), Positives = 99/243 (40%), Gaps = 45/243 (18%)

Query: 264  LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELR-- 321
            L++ +AQ +DAG YT  V+   + +    + V V  P    S+    P  E G  E++  
Sbjct: 1406 LQILNAQKEDAGQYTC-VVTNELGEAVKNYHVEVLIPP---SISKDDPLGEVGVKEVKTK 1461

Query: 322  ------LRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGD-QLLIVRPVR-SDH 373
                  L C  W      + W +DG+ +  +        R++  G+ +LL ++P + SD 
Sbjct: 1462 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSS-------RLQVLGEGRLLQIQPTQVSDS 1514

Query: 374  ARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAA---------------PARFV 418
             RY C   +  G  +   +V +     PP      D  AA                 R +
Sbjct: 1515 GRYLCVATNVAGEDDQDFNVLIQV---PPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1571

Query: 419  TAGSNVTLRCAAASRPPADITWSLADPA-----EAAVPAGSRLL-LPAVGPGHAGTYACL 472
               +   L C   + PP D+TW   D       E +V  G R+L +P V   +AG Y+C 
Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1631

Query: 473  AAN 475
            A+N
Sbjct: 1632 ASN 1634



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 113/490 (23%), Positives = 171/490 (34%), Gaps = 78/490 (15%)

Query: 219  PPTSLVVWRRGSKVLAAGGLGPGAPLISLD----PAHRD-HLRFDQARGVLELASAQLDD 273
            PPT + V + G   L     G   P ++ +    P   +  L+       L +  AQ   
Sbjct: 1073 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAH 1132

Query: 274  AGVYTAEVIR-AGVSQQTHEFTV-------GVYEPLPQLSVQPKAPETEEGAAELRLRCL 325
             G Y+      AG +++  E +V       G  +PL  ++    +P        L L C 
Sbjct: 1133 TGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP--------LTLLCE 1184

Query: 326  GWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFG 385
              G     + W R     E   S G +T  + + G  L + +    D   Y+C   +  G
Sbjct: 1185 AMGIPPPAIRWFRG----EEPVSPGEDT-YLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 1239

Query: 386  HREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS---- 441
                   V V     PP+I    + D      V  G    L C     P   +TW     
Sbjct: 1240 EARRNFSVEVLV---PPSI---ENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR 1293

Query: 442  --LADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQ 499
                  A    P G  L +       AG Y+C+AAN    + +   L++ +A    G  +
Sbjct: 1294 PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAE 1353

Query: 500  CSVEGGPGDRSLRFRCSWPGGAPAASLQFQG-----LPEGIRAGPVSSVLLAAVPAHPRL 554
             S      D  +    + P      +L F       + +G       ++ L      P  
Sbjct: 1354 DSA-----DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLL-----PGT 1403

Query: 555  SGVPITCLARHLVATRTCTVTPEAPR-------EVLLHPLVA-ETRLGEAEV-------- 598
             G+ I    +      TC VT E          EVL+ P ++ +  LGE  V        
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463

Query: 599  ---ALEA-SGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVL 654
                LE  S   PP    W ++G+P+ P   SRL++  +GR L I    +  D G Y  L
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGRLLQIQPTQVS-DSGRY--L 1518

Query: 655  CSGALGAGGD 664
            C     AG D
Sbjct: 1519 CVATNVAGED 1528



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 100/432 (23%), Positives = 155/432 (35%), Gaps = 58/432 (13%)

Query: 264  LELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRL 322
            L++    L D G+YT      AG S++  E  + V  P P +   P      E A+ + L
Sbjct: 659  LQIEKVDLRDEGIYTCAATNLAGESKR--EVALKVLVP-PNIEPGPVNKAVLENAS-VTL 714

Query: 323  RCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRS 382
             CL  G    ++SW +  + + +             +G  L I +   SD   Y C   +
Sbjct: 715  ECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-----DGRVLRIEQAQLSDAGSYRCVASN 769

Query: 383  PFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW-- 440
              G  E    + V     PP IT+           V   + V L C A   P   + W  
Sbjct: 770  VAGSTELRYGLRVNV---PPRITLPPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLK 822

Query: 441  ------SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
                      P     P G  L L +     +G Y+C+A +     R+  +L +    +P
Sbjct: 823  DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV---HMP 879

Query: 495  PG--APQCSVEGGPGDRSLRFRC-SWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAH 551
            P     + +V     + S+   C S     P  S    G P   R G    V L+A  A 
Sbjct: 880  PSILGEELNVSV-VANESVALECQSHAMPPPVLSWWKDGRPLEPRPG----VHLSADKAL 934

Query: 552  PRLSGVPITCLARHLVATRTCTVTPEAPRE----------VLLHPLVAETRLGEAE---- 597
             ++    +     +     TC    +A R             + PL     L   E    
Sbjct: 935  LQVDRADVWDAGHY-----TCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPT 989

Query: 598  -VALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCS 656
             ++ E  G P P + SW ++G+PL   G     +S  GR L++G   L  + G Y+  CS
Sbjct: 990  SLSCECRGVPFP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE-GTYTCECS 1047

Query: 657  GALGAGGDQITL 668
              +G     + L
Sbjct: 1048 NVVGNSSQDLQL 1059



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 116/511 (22%), Positives = 171/511 (33%), Gaps = 93/511 (18%)

Query: 203 VGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARG 262
           V  T+ L        G P   V WR+G       G  PG  ++                G
Sbjct: 13  VALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQ-PGVAVLE--------------EG 57

Query: 263 VLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRL 322
            L LAS    D+G Y  +     V   +    + VY P        KA  +      L L
Sbjct: 58  SLFLASVSPADSGDYECQATNE-VGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTL 116

Query: 323 RC----------------------LGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEG 360
            C                      LGW     +L W + G      E +    PR     
Sbjct: 117 ECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPR----- 171

Query: 361 DQLLIVRPVRSDH----ARYTCRVRSPFGHREAAADV----SVFYGPDPPTITVSSDRDA 412
                ++P RS      A  + + ++P+    A  +       F  P PP++  +    A
Sbjct: 172 -----IQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAG---A 223

Query: 413 APARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGP--------- 463
           A      AG++V L+C  +  P   + W+     +  +P G  L +   G          
Sbjct: 224 AQEVLGLAGADVELQCWTSGVPTPQVEWT--KDRQPVLPGGPHLQVQEDGQVLRITGSHV 281

Query: 464 GHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPA 523
           G  G Y C+A +P   + R   L +       G+ +        D  ++  C    G P 
Sbjct: 282 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCE-ARGVPT 340

Query: 524 ASLQFQGLPEGIRAGPVSSVL-------LAAVPAHPRLSGVPITCLARHLV-----ATRT 571
            ++ +    +G      + V+       L    A    +GV  TC A + V     ATR 
Sbjct: 341 PNITW--FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV-YTCKASNAVGAAEKATRL 397

Query: 572 CTVTPEAPREVLLHPLVAETRLGEAEVALE--ASGCPPPSRASWAREGRPLAPGGGSRLR 629
               P         P V +   G   VALE  A G P P+  SW  EG P+A    S  R
Sbjct: 398 DVYVPPTIEGAGGRPYVVKAVAGR-PVALECVARGHPSPT-LSWHHEGLPVAESNES--R 453

Query: 630 LSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
           L  DG  L + +   +   G YS + S   G
Sbjct: 454 LETDGSVLRLESPG-EASSGLYSCVASSPAG 483



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 87/395 (22%), Positives = 144/395 (36%), Gaps = 63/395 (15%)

Query: 333  ELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHA-RYTCRVRSPFGHREAAA 391
            +L+W R+ + L A +           +G ++L +  VR+++A RY+C+  +  G      
Sbjct: 1590 DLTWYREDQPLSAGDEVSV------LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 1643

Query: 392  DVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW------SLADP 445
            ++ V      P + +    +      V A S V+L+C A   P   I+W          P
Sbjct: 1644 ELLVL----TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP 1699

Query: 446  AEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPG--------- 496
                +  G  L +       A +Y C+A N      +   L + V     G         
Sbjct: 1700 RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI 1759

Query: 497  -----APQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAH 551
                 +  C V   P      ++ S          Q   L E +   P +  L       
Sbjct: 1760 LNSSVSLPCDVHAHPNPEVTWYKDS----------QALSLGEEVFLLPGTHTLQL---GR 1806

Query: 552  PRLSGVPI-TCLA-----RHLVATRTCTVTPEAPREVLLHPLVAE-TRLGE-AEVALEAS 603
             RLS   + TC A     R     +   + P A R+    P  A   R+G+ A ++ E  
Sbjct: 1807 ARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD 1866

Query: 604  GCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGG 663
              P P+  +W ++G+PL      R +  + G++L I    +  D G YS   S   G   
Sbjct: 1867 ALPEPT-VTWYKDGQPLVL--AQRTQALRGGQRLEIQEAQVS-DKGLYSCKVSNVAGEAV 1922

Query: 664  DQITL---IGPSISSWRLQRARDAA----VLTWDV 691
               TL   + P+  + + +     A    VLT DV
Sbjct: 1923 RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV 1957


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 142/587 (24%), Positives = 220/587 (37%), Gaps = 104/587 (17%)

Query: 102  QDLSPVSPFSETPGSEVFPDISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDS 161
            +D +PVSP + TPG +VFP                 +   ++  S    ++ ++V A   
Sbjct: 2013 KDGNPVSP-AGTPGLQVFPG-------------GRVLTLASARASDSGRYSCVAVSA--- 2055

Query: 162  KFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPT 221
                D  D+ L    P              P  +G  L V V     + L    +  PP 
Sbjct: 2056 -VGEDRQDVVLQVHMP--------------PSILGEELNVSVVANESVALECQSHAMPPP 2100

Query: 222  SLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEV 281
             L  W+ G                 L+P    HL  D+A  +L++  A + DAG YT E 
Sbjct: 2101 VLSWWKDGRP---------------LEPRPGVHLSADKA--LLQVDRADVWDAGHYTCEA 2143

Query: 282  I-RAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDG 340
            + +AG S++ +   V V    P   ++     T        L C   G    ++SW +DG
Sbjct: 2144 LNQAGHSEKHYNLNVWV---APVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDG 2200

Query: 341  RALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPD 400
            + L     EGA    + + G  L + +   +    YTC   +  G+      + V   P 
Sbjct: 2201 QPLPG---EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 2257

Query: 401  PPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL-ADPAEAAV-----PAGS 454
                 ++  R+      V      TL C A  +PP  +TW     P  A +       G 
Sbjct: 2258 -----IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 2312

Query: 455  RLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV-----ADLPPGAPQCSVEGGPGDR 509
             L +      H G Y+C+A N      R+  L++ V      DL P     +    P   
Sbjct: 2313 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP--- 2369

Query: 510  SLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVL-----LAAVPAHPRLSGVPITCLAR 564
             L   C   G  P A   F+G  E +  G  + +L     L       + SG+  +CLA 
Sbjct: 2370 -LTLLCEAMGIPPPAIRWFRG-EEPVSPGEDTYLLAGGWMLKMTQTQEQDSGL-YSCLAS 2426

Query: 565  HLV--ATRTCTVTPEAPREVLLHPLVAETRLGE---------AEVALEASGCPPPSRASW 613
            +    A R  +V      EVL+ P +    L E         A +    +G P P + +W
Sbjct: 2427 NEAGEARRNFSV------EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP-KLTW 2479

Query: 614  AREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
             ++GRPLA G      +S DG  L +   +L    G+YS + + A+G
Sbjct: 2480 FKDGRPLARGDAH--HISPDGVLLQVLQANLS-SAGHYSCIAANAVG 2523



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 133/544 (24%), Positives = 211/544 (38%), Gaps = 75/544 (13%)

Query: 137 TVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVG 196
           T++ P   +   +      ++AP      D ++L  S+  P      +  S  S  Q  G
Sbjct: 331 TLEWPLQGVPISLVINSTGLKAPGRL---DSVELAQSSGKPLLTLPTKPLSNGSTHQLWG 387

Query: 197 GPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHL- 255
           GP          L +    + G P   V        ++  G+ PGAPL+S+ P    +L 
Sbjct: 388 GPPFHTPKERFYLKVKGKDHEGNPLLRV------SGVSYSGVAPGAPLVSMAPRIHGYLH 441

Query: 256 ---------------RFDQARGVLELASAQ-LDDAGVYTAEVIRAGVSQQ-THEFT---- 294
                          R    RG   L   +   ++G  + E++RA  +++ T+E T    
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 501

Query: 295 ---------VGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEA 345
                    + V +P PQL   P    +    A L  R LG  P    L+W RD R L A
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAP--YNLTWVRDWRVLPA 559

Query: 346 AESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTIT 405
           +    A+   +  E     I   + +D  RY C   +  G   A+  + V    + P ++
Sbjct: 560 STGRVAQLADLSLE-----ISGIIPTDGGRYQCVASNANGVTRASVWLLV---REAPQVS 611

Query: 406 VSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS-----LADPAEAAVPAGSRLLLPA 460
           + +      ++  + G  V + C+A+  P   I+WS     L + +   V A   L++  
Sbjct: 612 IHTS-----SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 666

Query: 461 VGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP-GAPQCSVEGGPGDRSLRFRCSWPG 519
           V P  AG Y+C A N   G  + + + L   D P   A    V    G+ ++   C   G
Sbjct: 667 VAPEDAGNYSCQATN-EVGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEEAV-LVCEASG 723

Query: 520 GAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTV---TP 576
             P   + ++G  E I A   SS     +PA         TC A + +   +  +     
Sbjct: 724 VPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 783

Query: 577 EAPREVLLHPLVAETRLG-EAEVALEASGCPPPSRASWAR-EGRP----LAPGGGSRLRL 630
            AP+   L P      LG  A +A  A+G PPP+  +W R +G+P    L  G GSR R 
Sbjct: 784 HAPQLTEL-PRDVTVELGRSALLACRATGRPPPT-VTWRRGDGQPLGLRLGAGRGSRSRQ 841

Query: 631 SQDG 634
              G
Sbjct: 842 PDSG 845



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 119/436 (27%), Positives = 171/436 (39%), Gaps = 67/436 (15%)

Query: 262  GVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELR 321
            G L LA  Q+ D+G Y         S  +H + +GV  P PQ+   P+  +   G A L 
Sbjct: 1082 GSLRLAQVQVGDSGHYECTASNPAGSA-SHRYVLGVQVP-PQVQPGPRVLKVLVGEA-LD 1138

Query: 322  LRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVR 381
            L C+  G    +LSWS+DG  L+    +G+              +R   SD  RY C   
Sbjct: 1139 LNCVAEGNPEPQLSWSKDGVVLQGRGPQGSV---------HFAAIR--TSDAGRYRCEAS 1187

Query: 382  SPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS 441
            +  G      ++ V    +PP     +D  +     V AG N +L C A   P   +TW 
Sbjct: 1188 NSAGVDAWEVELRVL---EPP--HWGADETSGLLERV-AGENASLPCPARGTPKPQVTWR 1241

Query: 442  LADPAE-------AAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
                +E        AV     L L +V P  +G Y C A N      RR+ L   V  +P
Sbjct: 1242 KGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKL---VVYVP 1298

Query: 495  PG----APQCSVEGGPGDRSLRFRCSWPGGAPAASL------QFQGLPEGIRAGPVSSVL 544
            P       + +V G  G +SL   C    G P   +      Q  G+P G  AG    + 
Sbjct: 1299 PSIREDGRKANVSGMAG-QSLTLECD-ANGFPVPEIVWLKDAQLVGVPLG-WAGYGWDLG 1355

Query: 545  LAAVPAH-----------PRL----SGVPITCLARHLVAT--RTCTVTPEAPREVLLHPL 587
               V  H           PR+    SG+  +C A +   T  R   +    P  VL    
Sbjct: 1356 WGQVGGHRLLDEGQSLHFPRIQEGDSGL-YSCRAENQAGTAQRDFHLLVLTPPSVLGAGA 1414

Query: 588  VAET-RLGEAEVALE--ASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSL 644
              E   L  A+V L+   SG P P +  W ++ +P+ P GG  L++ +DG+ L I    +
Sbjct: 1415 AQEVLGLAGADVELQCWTSGVPTP-QVEWTKDRQPVLP-GGPHLQVQEDGQVLRITGSHV 1472

Query: 645  DWDLGNYSVLCSGALG 660
              D G Y  +     G
Sbjct: 1473 G-DEGRYQCVAFSPAG 1487



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 123/500 (24%), Positives = 188/500 (37%), Gaps = 77/500 (15%)

Query: 199  LAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFD 258
            +  ++ +++ LP     +P P    V W + S+ L+ G       +  L   H       
Sbjct: 2947 VTAILNSSVSLPCDVHAHPNPE---VTWYKDSQALSLG-----EEVFLLPGTH------- 2991

Query: 259  QARGVLELASAQLDDAGVYTAEVIRA-GVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGA 317
                 L+L  A+L D+G+YT E + A G  Q+  + +V V     Q    P+        
Sbjct: 2992 ----TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 3047

Query: 318  AELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYT 377
             +  L C         ++W +DG+ L  A+     T  +R  G +L I     SD   Y+
Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDGQPLVLAQ----RTQALRG-GQRLEIQEAQVSDKGLYS 3102

Query: 378  CRVRSPFGHREAAADVSVFYGP---DPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
            C+V +  G       ++V   P   +P T TVS            AGS + L C  +  P
Sbjct: 3103 CKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ----------VAGSPLVLTCDVSGVP 3152

Query: 435  PADITWSLAD--PAEAA-----VPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLN 487
               +TW L D  P E++     V  G RL L  + P  AGTY C+A N +   R+  ++ 
Sbjct: 3153 APTVTW-LKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVA 3211

Query: 488  LTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPA-ASLQFQGLPEGIRAGP------- 539
            + VA     +           + +R  C   G  P   +    G P G   GP       
Sbjct: 3212 VLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLD 3271

Query: 540  VSSVLLAAVPAHPRLSGVPITCLARHLVA--TRTCTVTPEAPREVLLHPLVAETRLGEAE 597
              S++L  + A         TC+A +      R  TV       VL+ P + +   G   
Sbjct: 3272 GGSLVLKGLRAS---DAGAYTCVAHNPAGEDARLHTV------NVLVPPTIKQGADGSGT 3322

Query: 598  VA-----LEASGCP----PPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDL 648
            +      L    CP    PP   SW ++G PL      R  L   G  L I    L  D 
Sbjct: 3323 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPL--SQRTLLHGSGHTLRISKVQLA-DA 3379

Query: 649  GNYSVLCSGALGAGGDQITL 668
            G ++ + +   G      TL
Sbjct: 3380 GIFTCVAASPAGVADRNFTL 3399



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 127/512 (24%), Positives = 192/512 (37%), Gaps = 61/512 (11%)

Query: 173  SAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKV 232
            +A S    F  E H+    P    GP AV V    +  L+P    G P  LV WR+    
Sbjct: 3657 AAGSTSVAFRVEIHTV---PTIRSGPPAVNVSVN-QTALLPCQADGVPAPLVSWRKDRV- 3711

Query: 233  LAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIR-AGVSQQTH 291
                 L P +P   + P            G L +      DAG Y       AG  +Q  
Sbjct: 3712 ----PLDPRSPRFEILP-----------EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGR 3756

Query: 292  EFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGA 351
            +  + V EP P ++  P +  T        L C   G  +  + W +DG+ L+    +GA
Sbjct: 3757 D--LRVLEP-PAIAPSP-SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGA 3812

Query: 352  ETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRD 411
                     + LL+  P   D A++ C V +  G       V+V     PPTI      D
Sbjct: 3813 ---YRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIA-----D 3861

Query: 412  AAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSR------LLLPAVGPGH 465
                  VT  + V L C +   P   ++WS A     A  +G R      L +    P H
Sbjct: 3862 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIH 3921

Query: 466  AGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAAS 525
            AG Y C A N      +   + LTV   P   P  SV     +  +   C    G P  +
Sbjct: 3922 AGRYTCSARNSAGVAHKH--VFLTVQASPVVKPLPSVVRAVAEEEVLLPCE-ASGIPRPT 3978

Query: 526  LQFQGLPEGIRAGPVSSVL----LAAVPAHPRLSGVPITCLARH-----LVATRTCTVTP 576
            + +Q     +  G  + VL    L    A P  +G    C+A++     +  TR     P
Sbjct: 3979 ITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAG-NYLCIAKNSAGSAMGKTRLVVQVP 4037

Query: 577  EAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRK 636
                  L  P ++ T    A +  +A G P P+  +W ++G+P++ G   +  +   G +
Sbjct: 4038 PVIENGL--PDLSTTEGSHAFLPCKARGSPEPN-ITWDKDGQPVS-GAEGKFTIQPSG-E 4092

Query: 637  LHIGNFSLDWDLGNYSVLCSGALGAGGDQITL 668
            L + N     D G Y+     A+G    ++ L
Sbjct: 4093 LLVKNLE-GQDAGTYTCTAENAVGRARRRVHL 4123



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 103/424 (24%), Positives = 160/424 (37%), Gaps = 58/424 (13%)

Query: 218  GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
            G PT  V W +  + +  GG                HL+  +   VL +  + + D G Y
Sbjct: 1434 GVPTPQVEWTKDRQPVLPGG---------------PHLQVQEDGQVLRITGSHVGDEGRY 1478

Query: 278  TAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAEL-RLRCLGWGPGRGELSW 336
               V  +   QQ  +F + V+ P P +    +  E       L +L C   G     ++W
Sbjct: 1479 QC-VAFSPAGQQARDFQLRVHAP-PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 1536

Query: 337  SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVF 396
             +DG  L  +     +    R  G QL + R   SD   YTC+  +  G  E A  + V+
Sbjct: 1537 FKDGALLPTS----TKVVYTRG-GRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 1591

Query: 397  YGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS-----LADPAEAAVP 451
                PPTI  +  R         AG  V L C A   P   ++W      +A+  E+ + 
Sbjct: 1592 V---PPTIEGAGGRPYVVK--AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLE 1646

Query: 452  A-GSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGD-- 508
              GS L L + G   +G Y+C+A++P       ++L  +V    P  PQ  V  G G   
Sbjct: 1647 TDGSVLRLESPGEASSGLYSCVASSP----AGEAVLQYSVEVQVP--PQLLVAEGLGQVT 1700

Query: 509  ----RSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLAR 564
                + L   C    G+P  ++Q+  L  G  A  ++ V +A+      +  V +     
Sbjct: 1701 TIVGQPLELPCQ-ASGSPVPTIQW--LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGL 1757

Query: 565  HLVATRTCTVTPEAPREVLLH----PLVAETRLGEAEVALE-----ASGCPPPSRASWAR 615
                      T  A  EV +H    P V E  +G+     E      + C PP    W  
Sbjct: 1758 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 1817

Query: 616  EGRP 619
              +P
Sbjct: 1818 HPKP 1821



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 156/608 (25%), Positives = 220/608 (36%), Gaps = 103/608 (16%)

Query: 218  GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
            G P   V W +    L A G G       + P+           G LE+  A    AG Y
Sbjct: 3882 GIPAPTVSWSKAGAQLGARGSG-----YRVSPS-----------GALEIGQALPIHAGRY 3925

Query: 278  TAEVIR-AGVSQQTHEFTVG---VYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGE 333
            T      AGV+ +    TV    V +PLP + V+  A E      E+ L C   G  R  
Sbjct: 3926 TCSARNSAGVAHKHVFLTVQASPVVKPLPSV-VRAVAEE------EVLLPCEASGIPRPT 3978

Query: 334  LSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADV 393
            ++W ++G  +    + G  T  +   G QL I      D   Y C  ++  G       +
Sbjct: 3979 ITWQKEGLNV----ATGVSTQVL--PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRL 4032

Query: 394  SVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL-ADPAEAA--- 449
             V     PP I      +  P    T GS+  L C A   P  +ITW     P   A   
Sbjct: 4033 VVQV---PPVI-----ENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGK 4084

Query: 450  --VPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPG 507
              +     LL+  +    AGTY C A N   GR RR  ++LT+  LP           PG
Sbjct: 4085 FTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRR-VHLTILVLPVFTTL------PG 4136

Query: 508  DRSLR------FRCSWPGGAPAASLQF----QGLPEGIRAGPVSSVLLAAVPAHPRLSGV 557
            DRSLR       RC+   G+P   + +    + + EG+      S L  A  A  R    
Sbjct: 4137 DRSLRLGDRLWLRCA-ARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRA--AVSREDSG 4193

Query: 558  PITCLARHLVATRTCTVT----PEAP-REVLLHPLVAETRLGEAEVALEASGCPPPSRAS 612
               C A + V  RT  V+     EAP  +      + E   G  ++     G P P    
Sbjct: 4194 TYVCWAENRVG-RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IH 4251

Query: 613  WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITLIGPS 672
            W ++G PL    GS LR       L I     D D G Y  L    +G     + L+  S
Sbjct: 4252 WIKDGLPLR---GSHLRHQLQNGSLTIHRTERD-DAGRYQCLAENEMGVAKKVVILVLQS 4307

Query: 673  ISSWRLQ------RARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRD---WVSL 723
               ++++      R+ D   L          +   +QA     A  R  T  D   W+  
Sbjct: 4308 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLEN 4367

Query: 724  LILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGIVLG 783
            +  G             + GT+      +LG    T     V R  P  S G++ G++ G
Sbjct: 4368 VETG-------------DAGTYDCVAHNLLGS--ATARAFLVVRGEPQGSWGSMTGVING 4412

Query: 784  SLLGLALL 791
               G+A L
Sbjct: 4413 RKFGVATL 4420



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 121/483 (25%), Positives = 178/483 (36%), Gaps = 66/483 (13%)

Query: 197  GPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLR 256
            G +  +VG  + LP     +P P    +   R ++ LA   +      + +D    DH  
Sbjct: 1697 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 1756

Query: 257  FDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTH-EFTVGVYE-PLPQLSVQPKAPETE 314
                      A    ++AG   AEV         H E+  GV E P+ Q     +   + 
Sbjct: 1757 L--------FACQATNEAGTAGAEV-----EVSVHGEWAPGVLEVPIGQYHWGXEHHSSF 1803

Query: 315  EGAAELRLRCLGWG----PGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVR 370
              A +  +   GWG    P   E  W   G    +   E    P   S    L I +   
Sbjct: 1804 PAACDPPVH-RGWGAHPKPPLVE-GWCSPG----SLWGEPTGIPVAYSLPPPLQIEKVDL 1857

Query: 371  SDHARYTCRVRSPFGH--REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRC 428
             D   YTC   +  G   RE A  V V     PP I       A     V   ++VTL C
Sbjct: 1858 RDEGIYTCAATNLAGESKREVALKVLV-----PPNIEPGPVNKA-----VLENASVTLEC 1907

Query: 429  AAASRPPADITW-----SLADPAEAAVPAGSRLL-LPAVGPGHAGTYACLAANPRTGRRR 482
             A+  PP D++W      ++      V    R+L +       AG+Y C+A+N       
Sbjct: 1908 LASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967

Query: 483  RSLLNLTV---ADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGP 539
            R  L + V     LPP  P   +   P    +R  C+   GAP+ +L +  L +G    P
Sbjct: 1968 RYGLRVNVPPRITLPPSLPGPVLVNTP----VRLTCN-ATGAPSPTLMW--LKDGNPVSP 2020

Query: 540  VSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGE---- 595
              +  L   P    L+            +    +   E  ++V+L   +  + LGE    
Sbjct: 2021 AGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNV 2080

Query: 596  -----AEVALEA-SGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLG 649
                   VALE  S   PP   SW ++GRPL P  G  + LS D   L +    + WD G
Sbjct: 2081 SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG--VHLSADKALLQVDRADV-WDAG 2137

Query: 650  NYS 652
            +Y+
Sbjct: 2138 HYT 2140



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 127/485 (26%), Positives = 177/485 (36%), Gaps = 82/485 (16%)

Query: 214  IPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASA---- 269
            I + G PT L +       L     G   P I+    H+D     QA   LE  S     
Sbjct: 3496 IEDSGQPTELSLTPGAPMELLCDAQGTPQPNITW---HKD----GQALTRLENNSRATRV 3548

Query: 270  -QLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAA--ELRLRCLG 326
             ++ DAG+YT  +  +        F V V  P P + V P+ P    G A  +L L C  
Sbjct: 3549 LRVRDAGLYTC-LAESPAGAIEKSFRVRVQAP-PNI-VGPRGPRFVVGLAPGQLVLECSV 3605

Query: 327  WGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGH 386
                  +++W RDG  L+    E A T +    G  L +     +D   Y+C  R+  G 
Sbjct: 3606 EAEPAPKITWHRDGIVLQ----EDAHT-QFPERGRFLQLQALSTADSGDYSCTARNAAGS 3660

Query: 387  REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW------ 440
               A  V +         TV + R   PA  V+      L C A   P   ++W      
Sbjct: 3661 TSVAFRVEIH--------TVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 3712

Query: 441  -SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAAN----PRTGRRRRSL---------L 486
                 P    +P GS  + P +    AG Y CLA+N     R GR  R L          
Sbjct: 3713 LDPRSPRFEILPEGSLRIQPVLAQ-DAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 3771

Query: 487  NLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLA 546
            NLT+    P    C   G P    +     W  G     L F+      R  P +++LL 
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVV----WWKDG---QKLDFRLQQGAYRLLPSNALLLT 3824

Query: 547  AVPAHPRLSGVPITCLARHLV--ATRTCTVTPEAPREVLLHPLVAE-------TRLGEAE 597
            A             C+  + V  A R   VT   P      P +A+       T +    
Sbjct: 3825 APGPQ---DSAQFECVVSNEVGEAHRLYQVTVHVP------PTIADDQTDFTVTMMAPVV 3875

Query: 598  VALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSG 657
            +   ++G P P+  SW++ G  L    GS  R+S  G  L IG  +L    G Y+  CS 
Sbjct: 3876 LTCHSTGIPAPT-VSWSKAGAQLG-ARGSGYRVSPSG-ALEIGQ-ALPIHAGRYT--CSA 3929

Query: 658  ALGAG 662
               AG
Sbjct: 3930 RNSAG 3934



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 124/491 (25%), Positives = 171/491 (34%), Gaps = 89/491 (18%)

Query: 201  VLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQA 260
            VL G  +RL       P P    V W +    L    +GP             HLRF   
Sbjct: 3229 VLEGQEVRLDCEADGQPPPD---VAWLKDGSPLGQD-MGP-------------HLRFYLD 3271

Query: 261  RGVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAE 319
             G L L   +  DAG YT      AG   + H  TV V  P       P   +  +G+  
Sbjct: 3272 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLH--TVNVLVP-------PTIKQGADGSGT 3322

Query: 320  LRLR--------CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRS 371
            L  R        C   G     +SW +DG  L  ++        +   G  L I +   +
Sbjct: 3323 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT-----LLHGSGHTLRISKVQLA 3377

Query: 372  DHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAA 431
            D   +TC   SP G  +    + V   P    +   +D        V  GS V L C A 
Sbjct: 3378 DAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDV------VVVRGSLVELPCEAR 3431

Query: 432  SRPPADITWSL-ADPA-EAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLT 489
              P   ++W    +P    ++  G  L L AVG G +GTY+C+A +     RR     LT
Sbjct: 3432 GVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLT 3489

Query: 490  VADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVP 549
            V +     P     G P + SL      PG         QG P+           L  + 
Sbjct: 3490 VME----PPHIEDSGQPTELSLT-----PGAPMELLCDAQGTPQPNITWHKDGQALTRLE 3540

Query: 550  AHPRLSGV-------PITCLA-----------RHLVATRTCTVTPEAPREVLLHPLVAET 591
             + R + V         TCLA           R  V      V P  PR V+        
Sbjct: 3541 NNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVV-------- 3592

Query: 592  RLGEAEVALEAS-GCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGN 650
             L   ++ LE S    P  + +W R+G  L     +  +  + GR L +   S   D G+
Sbjct: 3593 GLAPGQLVLECSVEAEPAPKITWHRDGIVLQE--DAHTQFPERGRFLQLQALSTA-DSGD 3649

Query: 651  YSVLCSGALGA 661
            YS     A G+
Sbjct: 3650 YSCTARNAAGS 3660



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 130/513 (25%), Positives = 187/513 (36%), Gaps = 94/513 (18%)

Query: 192  PQQVGGP--LAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDP 249
            PQ   GP  L VLVG  + L  V   NP P  S   W +   VL   G GP         
Sbjct: 1120 PQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLS---WSKDGVVLQ--GRGP--------- 1165

Query: 250  AHRDHLRFDQARGVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQP 308
                       +G +  A+ +  DAG Y  E    AGV     E  + V EP P      
Sbjct: 1166 -----------QGSVHFAAIRTSDAGRYRCEASNSAGVD--AWEVELRVLEP-PHWGADE 1211

Query: 309  KAPETEEGAAE-LRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVR 367
             +   E  A E   L C   G  + +++W R G + E     G     +  EG  L +  
Sbjct: 1212 TSGLLERVAGENASLPCPARGTPKPQVTW-RKGPSSEPLH--GQPGVAVLEEGS-LFLAS 1267

Query: 368  PVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLR 427
               +D   Y C+  +  G     A + V+    PP+I     +         AG ++TL 
Sbjct: 1268 VSPADSGDYECQATNEVGSTSRRAKLVVYV---PPSIREDGRKANVSGM---AGQSLTLE 1321

Query: 428  CAAASRPPADITWSLADPAEAAVP---------------AGSRLL-------LPAVGPGH 465
            C A   P  +I W L D     VP                G RLL        P +  G 
Sbjct: 1322 CDANGFPVPEIVW-LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGD 1380

Query: 466  AGTYACLAANPR-TGRRRRSLLNLTVADLPP---GAPQCSVEGGPGDRSLRFRCSWPGGA 521
            +G Y+C A N   T +R   LL LT    PP   GA       G     +  +C W  G 
Sbjct: 1381 SGLYSCRAENQAGTAQRDFHLLVLT----PPSVLGAGAAQEVLGLAGADVELQC-WTSGV 1435

Query: 522  PAASLQFQG-----LPEGIRA-----GPVSSVLLAAVPAHPRLSGVPITCLARHLVATRT 571
            P   +++       LP G        G V  +  + V    R   V  +   +     R 
Sbjct: 1436 PTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ---ARD 1492

Query: 572  CTVTPEAPREVLLHPLVAETRLGE---AEVALEASGCPPPSRASWAREGRPLAPGGGSRL 628
              +   AP  +       E  + E    ++  EA G P P+  +W ++G  L     +++
Sbjct: 1493 FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN-ITWFKDGALLPT--STKV 1549

Query: 629  RLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGA 661
              ++ GR+L +G  +   D G Y+   S A+GA
Sbjct: 1550 VYTRGGRQLQLGR-AQSSDAGVYTCKASNAVGA 1581



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 62/243 (25%), Positives = 99/243 (40%), Gaps = 45/243 (18%)

Query: 264  LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELR-- 321
            L++ +AQ +DAG YT  V+   + +    + V V  P    S+    P  E G  E++  
Sbjct: 2597 LQILNAQKEDAGQYTC-VVTNELGEAVKNYHVEVLIPP---SISKDDPLGEVGVKEVKTK 2652

Query: 322  ------LRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGD-QLLIVRPVR-SDH 373
                  L C  W      + W +DG+ +  +        R++  G+ +LL ++P + SD 
Sbjct: 2653 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSS-------RLQVLGEGRLLQIQPTQVSDS 2705

Query: 374  ARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAA---------------PARFV 418
             RY C   +  G  +   +V +     PP      D  AA                 R +
Sbjct: 2706 GRYLCVATNVAGEDDQDFNVLIQV---PPMFQKVGDFSAAFEILSREEEARGGVTEYREI 2762

Query: 419  TAGSNVTLRCAAASRPPADITWSLADPA-----EAAVPAGSRLL-LPAVGPGHAGTYACL 472
               +   L C   + PP D+TW   D       E +V  G R+L +P V   +AG Y+C 
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 2822

Query: 473  AAN 475
            A+N
Sbjct: 2823 ASN 2825



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 113/490 (23%), Positives = 171/490 (34%), Gaps = 78/490 (15%)

Query: 219  PPTSLVVWRRGSKVLAAGGLGPGAPLISLD----PAHRD-HLRFDQARGVLELASAQLDD 273
            PPT + V + G   L     G   P ++ +    P   +  L+       L +  AQ   
Sbjct: 2264 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAH 2323

Query: 274  AGVYTAEVIR-AGVSQQTHEFTV-------GVYEPLPQLSVQPKAPETEEGAAELRLRCL 325
             G Y+      AG +++  E +V       G  +PL  ++    +P        L L C 
Sbjct: 2324 TGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP--------LTLLCE 2375

Query: 326  GWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFG 385
              G     + W R     E   S G +T  + + G  L + +    D   Y+C   +  G
Sbjct: 2376 AMGIPPPAIRWFRG----EEPVSPGEDT-YLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 2430

Query: 386  HREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS---- 441
                   V V     PP+I    + D      V  G    L C     P   +TW     
Sbjct: 2431 EARRNFSVEVLV---PPSI---ENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR 2484

Query: 442  --LADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQ 499
                  A    P G  L +       AG Y+C+AAN    + +   L++ +A    G  +
Sbjct: 2485 PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAE 2544

Query: 500  CSVEGGPGDRSLRFRCSWPGGAPAASLQFQG-----LPEGIRAGPVSSVLLAAVPAHPRL 554
             S      D  +    + P      +L F       + +G       ++ L      P  
Sbjct: 2545 DSA-----DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLL-----PGT 2594

Query: 555  SGVPITCLARHLVATRTCTVTPEAPR-------EVLLHPLVA-ETRLGEAEV-------- 598
             G+ I    +      TC VT E          EVL+ P ++ +  LGE  V        
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654

Query: 599  ---ALEA-SGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVL 654
                LE  S   PP    W ++G+P+ P   SRL++  +GR L I    +  D G Y  L
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGRLLQIQPTQVS-DSGRY--L 2709

Query: 655  CSGALGAGGD 664
            C     AG D
Sbjct: 2710 CVATNVAGED 2719



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 110/476 (23%), Positives = 163/476 (34%), Gaps = 72/476 (15%)

Query: 218  GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
            G PT  + W R S+ L                  R H+    A+G L +     +DAG Y
Sbjct: 633  GYPTPHISWSRESQALQEDS--------------RIHV---DAQGTLIIQGVAPEDAGNY 675

Query: 278  TAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSW 336
            + +     G  Q+T    V +Y   P       A        E  L C   G     + W
Sbjct: 676  SCQATNEVGTDQET----VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW 731

Query: 337  SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVF 396
             R G  +  A  EG+ + ++R    Q         D   YTCR  +  G  +A+A++ + 
Sbjct: 732  YRGGLEMILAP-EGSSSGKLRIPAAQ-------ERDAGTYTCRAVNELG--DASAEIQLA 781

Query: 397  YGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLAD------------ 444
             G  P    +  D        V  G +  L C A  RPP  +TW   D            
Sbjct: 782  VGHAPQLTELPRDVT------VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR 835

Query: 445  PAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP----GAPQC 500
             + +  P    L   +V P     Y C A N   G+ +     +     PP     AP  
Sbjct: 836  GSRSRQPDSGVLFFESVAPEDQAPYVCEARNV-FGKVQAEARLIVTGHAPPQIASSAPTV 894

Query: 501  SV-EGGPGDRSLRFRCSWPGGAPAASLQF----QGLPEGIRAGPVSSVLLAAVPAHPRLS 555
             V EG P    +   C    G P     +    + LP G R    +   L    A    +
Sbjct: 895  RVLEGQP----VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHA 950

Query: 556  GVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGE---AEVALEASGCPPPSRAS 612
            G   +C+A +   ++   V         +HP        E   A +   ASG P P+  +
Sbjct: 951  G-RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT-IT 1008

Query: 613  WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITL 668
            W +E   L    G    +S++G  L I   S   D G Y    +  +G    ++ L
Sbjct: 1009 WTKETNALT-SRGPHYNVSKEGTLL-IAQPSAQ-DAGAYVCTATNTVGFSSQEMRL 1061



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 101/430 (23%), Positives = 154/430 (35%), Gaps = 54/430 (12%)

Query: 264  LELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRL 322
            L++    L D G+YT      AG S++  E  + V  P P +   P      E A+ + L
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKR--EVALKVLVP-PNIEPGPVNKAVLENAS-VTL 1905

Query: 323  RCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRS 382
             CL  G    ++SW +  + + +             +G  L I +   SD   Y C   +
Sbjct: 1906 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-----DGRVLRIEQAQLSDAGSYRCVASN 1960

Query: 383  PFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW-- 440
              G  E    + V     PP IT+           V   + V L C A   P   + W  
Sbjct: 1961 VAGSTELRYGLRVNV---PPRITLPPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLK 2013

Query: 441  ------SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
                      P     P G  L L +     +G Y+C+A +     R+  +L +    +P
Sbjct: 2014 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV---HMP 2070

Query: 495  PG--APQCSVEGGPGDRSLRFRC-SWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAH 551
            P     + +V     + S+   C S     P  S    G P   R G    V L+A  A 
Sbjct: 2071 PSILGEELNVSV-VANESVALECQSHAMPPPVLSWWKDGRPLEPRPG----VHLSADKAL 2125

Query: 552  PRLSGVPI------TCLARHLVA------TRTCTVTPEAPREVLLHPLVAETRLGE-AEV 598
             ++    +      TC A +              V P  P   L        R G    +
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP---LRESHTLTVREGHPTSL 2182

Query: 599  ALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGA 658
            + E  G P P + SW ++G+PL   G     +S  GR L++G   L  + G Y+  CS  
Sbjct: 2183 SCECRGVPFP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE-GTYTCECSNV 2240

Query: 659  LGAGGDQITL 668
            +G     + L
Sbjct: 2241 VGNSSQDLQL 2250



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 87/395 (22%), Positives = 144/395 (36%), Gaps = 63/395 (15%)

Query: 333  ELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHA-RYTCRVRSPFGHREAAA 391
            +L+W R+ + L A +           +G ++L +  VR+++A RY+C+  +  G      
Sbjct: 2781 DLTWYREDQPLSAGDEVSV------LQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY 2834

Query: 392  DVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW------SLADP 445
            ++ V      P + +    +      V A S V+L+C A   P   I+W          P
Sbjct: 2835 ELLVL----TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP 2890

Query: 446  AEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPG--------- 496
                +  G  L +       A +Y C+A N      +   L + V     G         
Sbjct: 2891 RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI 2950

Query: 497  -----APQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAH 551
                 +  C V   P      ++ S          Q   L E +   P +  L       
Sbjct: 2951 LNSSVSLPCDVHAHPNPEVTWYKDS----------QALSLGEEVFLLPGTHTLQL---GR 2997

Query: 552  PRLSGVPI-TCLA-----RHLVATRTCTVTPEAPREVLLHPLVAE-TRLGE-AEVALEAS 603
             RLS   + TC A     R     +   + P A R+    P  A   R+G+ A ++ E  
Sbjct: 2998 ARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD 3057

Query: 604  GCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGG 663
              P P+  +W ++G+PL      R +  + G++L I    +  D G YS   S   G   
Sbjct: 3058 ALPEPT-VTWYKDGQPLVL--AQRTQALRGGQRLEIQEAQVS-DKGLYSCKVSNVAGEAV 3113

Query: 664  DQITL---IGPSISSWRLQRARDAA----VLTWDV 691
               TL   + P+  + + +     A    VLT DV
Sbjct: 3114 RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDV 3148



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 131/566 (23%), Positives = 182/566 (32%), Gaps = 121/566 (21%)

Query: 247  LDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSV 306
            L P  R  +R D   G L L  A  + AG Y+        SQ  H     V +  P++  
Sbjct: 926  LPPGSRHSIRAD---GSLHLDRALQEHAGRYSCVATNTAGSQ--HRDVELVVQVPPRIHP 980

Query: 307  QPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIV 366
                  T EG     L C+  G     ++W+++  AL    S G     +  EG  LLI 
Sbjct: 981  TATHHITNEGVPA-SLPCVASGVPAPTITWTKETNALT---SRGPHY-NVSKEGT-LLIA 1034

Query: 367  RPVRSDHARYTCRVRSPFGHREAAADVSV-----------FYGPDPP------------- 402
            +P   D   Y C   +  G       +SV            YG  P              
Sbjct: 1035 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDS 1094

Query: 403  ---TITVSSDRDAAPARF------------------VTAGSNVTLRCAAASRPPADITWS 441
                 T S+   +A  R+                  V  G  + L C A   P   ++WS
Sbjct: 1095 GHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWS 1154

Query: 442  LADPA-EAAVPAGSRLLLPAVGPGHAGTYACLAAN----------------PRTGRRRRS 484
                  +   P GS +   A+    AG Y C A+N                P  G    S
Sbjct: 1155 KDGVVLQGRGPQGS-VHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETS 1213

Query: 485  LLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVL 544
             L   VA      P C   G P     + + +W  G  +  L  Q    G+      S+ 
Sbjct: 1214 GLLERVAGENASLP-CPARGTP-----KPQVTWRKGPSSEPLHGQ---PGVAVLEEGSLF 1264

Query: 545  LAAVPAHPRLSGVPITCLARHLVAT-----RTCTVTPEAPREVLLHPLVAETRLGEAEVA 599
            LA+V   P  SG    C A + V +     +     P + RE      V+        + 
Sbjct: 1265 LASV--SPADSG-DYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 1321

Query: 600  LEASGCPPPS------------RASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWD 647
             +A+G P P                WA  G  L  G     RL  +G+ LH      + D
Sbjct: 1322 CDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ-EGD 1380

Query: 648  LGNYSVLCSGALGAGGDQ-----ITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEI 702
             G YS  C     AG  Q     + L  PS+    L       VL      G   +  E+
Sbjct: 1381 SGLYS--CRAENQAGTAQRDFHLLVLTPPSV----LGAGAAQEVL------GLAGADVEL 1428

Query: 703  QAWPDGPALGRTSTYRDWVSLLILGP 728
            Q W  G    +    +D   +L  GP
Sbjct: 1429 QCWTSGVPTPQVEWTKDRQPVLPGGP 1454


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 133/544 (24%), Positives = 211/544 (38%), Gaps = 75/544 (13%)

Query: 137 TVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVG 196
           T++ P   +   +      ++AP      D ++L  S+  P      +  S  S  Q  G
Sbjct: 214 TLEWPLQGVPISLVINSTGLKAPGRL---DSVELAQSSGKPLLTLPTKPLSNGSTHQLWG 270

Query: 197 GPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHL- 255
           GP          L +    + G P   V        ++  G+ PGAPL+S+ P    +L 
Sbjct: 271 GPPFHTPKERFYLKVKGKDHEGNPLLRV------SGVSYSGVAPGAPLVSMAPRIHGYLH 324

Query: 256 ---------------RFDQARGVLELASAQ-LDDAGVYTAEVIRAGVSQQ-THEFT---- 294
                          R    RG   L   +   ++G  + E++RA  +++ T+E T    
Sbjct: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 384

Query: 295 ---------VGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEA 345
                    + V +P PQL   P    +    A L  R LG  P    L+W RD R L A
Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAP--YNLTWVRDWRVLPA 442

Query: 346 AESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTIT 405
           +    A+   +  E     I   + +D  RY C   +  G   A+  + V    + P ++
Sbjct: 443 STGRVAQLADLSLE-----ISGIIPTDGGRYQCVASNANGVTRASVWLLV---REAPQVS 494

Query: 406 VSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS-----LADPAEAAVPAGSRLLLPA 460
           + +      ++  + G  V + C+A+  P   I+WS     L + +   V A   L++  
Sbjct: 495 IHTS-----SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 549

Query: 461 VGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP-GAPQCSVEGGPGDRSLRFRCSWPG 519
           V P  AG Y+C A N   G  + + + L   D P   A    V    G+ ++   C   G
Sbjct: 550 VAPEDAGNYSCQATN-EVGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEEAV-LVCEASG 606

Query: 520 GAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTV---TP 576
             P   + ++G  E I A   SS     +PA         TC A + +   +  +     
Sbjct: 607 VPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 666

Query: 577 EAPREVLLHPLVAETRLG-EAEVALEASGCPPPSRASWAR-EGRP----LAPGGGSRLRL 630
            AP+   L P      LG  A +A  A+G PPP+  +W R +G+P    L  G GSR R 
Sbjct: 667 HAPQLTEL-PRDVTVELGRSALLACRATGRPPPT-VTWRRGDGQPLGLRLGAGRGSRSRQ 724

Query: 631 SQDG 634
              G
Sbjct: 725 PDSG 728



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 135/503 (26%), Positives = 185/503 (36%), Gaps = 96/503 (19%)

Query: 218  GPPTSLVVWRRGS--KVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAG 275
            G P   V+W RG    +LA  G                      + G L + +AQ  DAG
Sbjct: 606  GVPPPRVIWYRGGLEMILAPEG---------------------SSSGKLRIPAAQERDAG 644

Query: 276  VYTAEVIRA-GVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGEL 334
             YT   +   G +    +  VG     PQL+  P+    E G + L L C   G     +
Sbjct: 645  TYTCRAVNELGDASAEIQLAVG---HAPQLTELPRDVTVELGRSAL-LACRATGRPPPTV 700

Query: 335  SWSR-DGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADV 393
            +W R DG+ L      G  +   + +   L        D A Y C  R+ FG  +A A +
Sbjct: 701  TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760

Query: 394  SVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAA-ASRPPADITWSLADPAEAAVPA 452
             V  G  PP I  S     AP   V  G  V+L C   A RP  +  W L D     +P 
Sbjct: 761  IVT-GHAPPQIASS-----APTVRVLEGQPVSLPCIVLAGRPLPERHW-LKDGRP--LPP 811

Query: 453  GSRLLLPAVGP--------GHAGTYACLAANPRTGRRRRSLLNLTVADL--PPGAPQCSV 502
            GSR  + A G          HAG Y+C+A N    + R   L + V     P      + 
Sbjct: 812  GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN 871

Query: 503  EGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRA-GPVSSV-----LLAAVPAHPRLSG 556
            EG P   SL    S   G PA ++ +      + + GP  +V     LL A P+      
Sbjct: 872  EGVPA--SLPCVAS---GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGA 926

Query: 557  VPITCLARHLVATRTCTVTPEAPREVLLH---------PLVAETRLGEAEVAL--EASGC 605
                C A + V   +  +      +  +H         PL    + GE EV L  EA G 
Sbjct: 927  Y--VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE-EVTLDCEAKGS 983

Query: 606  PPPSRASWAREGRP---------LAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCS 656
            PPP   +W ++ RP         L P G  RL   Q G            D G+Y    S
Sbjct: 984  PPPL-VTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVG------------DSGHYECTAS 1030

Query: 657  GALGAGGDQITLIGPSISSWRLQ 679
               G+   +  L     +SW+ Q
Sbjct: 1031 NPAGSASHRYVLGVQGRTSWQPQ 1053



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 110/476 (23%), Positives = 163/476 (34%), Gaps = 72/476 (15%)

Query: 218 GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
           G PT  + W R S+ L                  R H+    A+G L +     +DAG Y
Sbjct: 516 GYPTPHISWSRESQALQEDS--------------RIHV---DAQGTLIIQGVAPEDAGNY 558

Query: 278 TAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSW 336
           + +     G  Q+T    V +Y   P       A        E  L C   G     + W
Sbjct: 559 SCQATNEVGTDQET----VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW 614

Query: 337 SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVF 396
            R G  +  A  EG+ + ++R    Q         D   YTCR  +  G  +A+A++ + 
Sbjct: 615 YRGGLEMILAP-EGSSSGKLRIPAAQ-------ERDAGTYTCRAVNELG--DASAEIQLA 664

Query: 397 YGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLAD------------ 444
            G  P    +  D        V  G +  L C A  RPP  +TW   D            
Sbjct: 665 VGHAPQLTELPRDVT------VELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR 718

Query: 445 PAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP----GAPQC 500
            + +  P    L   +V P     Y C A N   G+ +     +     PP     AP  
Sbjct: 719 GSRSRQPDSGVLFFESVAPEDQAPYVCEARNV-FGKVQAEARLIVTGHAPPQIASSAPTV 777

Query: 501 SV-EGGPGDRSLRFRCSWPGGAPAASLQF----QGLPEGIRAGPVSSVLLAAVPAHPRLS 555
            V EG P    +   C    G P     +    + LP G R    +   L    A    +
Sbjct: 778 RVLEGQP----VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHA 833

Query: 556 GVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGE---AEVALEASGCPPPSRAS 612
           G   +C+A +   ++   V         +HP        E   A +   ASG P P+  +
Sbjct: 834 G-RYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT-IT 891

Query: 613 WAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITL 668
           W +E   L    G    +S++G  L I   S   D G Y    +  +G    ++ L
Sbjct: 892 WTKETNALT-SRGPHYNVSKEGTLL-IAQPSAQ-DAGAYVCTATNTVGFSSQEMRL 944


>gi|21314600 carcinoembryonic antigen-related cell adhesion molecule
           8 [Homo sapiens]
          Length = 349

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 65/226 (28%), Positives = 109/226 (48%), Gaps = 25/226 (11%)

Query: 272 DDAGVYTAEVIRAGVSQQ--THEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP 329
           +D G YT +VI+  +  +  T +F+V    P P +S     P  ++ A  +   C     
Sbjct: 115 NDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDA--VAFTCEPETQ 172

Query: 330 GRGELSWSRDGRALEAAESEGAETPRMR-SEGDQLLIVRPV-RSDHARYTCRVRSPFGHR 387
               L W  +G++L  +       PR++ S G++ L +  V R+D   Y C +++P    
Sbjct: 173 NTTYLWWV-NGQSLPVS-------PRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASAN 224

Query: 388 EA-AADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPA 446
            +    ++V YGPD PTI+ S         +  AG N+ L C AAS PP+  +WS+    
Sbjct: 225 FSDPVTLNVLYGPDAPTISPSDT-------YYHAGVNLNLSCHAASNPPSQYSWSVNGTF 277

Query: 447 EAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVAD 492
           +       +L +P +   ++G+YAC   N  TGR R ++  +TV+D
Sbjct: 278 QQYT---QKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSD 320


>gi|68161541 carcinoembryonic antigen-related cell adhesion molecule
           1 isoform 2 precursor [Homo sapiens]
          Length = 464

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 66/253 (26%), Positives = 114/253 (45%), Gaps = 26/253 (10%)

Query: 272 DDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGR 331
           +D G YT +VI++ +  +       VY  LP+ S+        E    +   C       
Sbjct: 115 NDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDT 174

Query: 332 GELSWSRDGRALEAAESEGAETPRMR-SEGDQLLIVRPV-RSDHARYTCRVRSPFG-HRE 388
             L W  + ++L  +       PR++ S G++ L +  V R+D   Y C +++P   +R 
Sbjct: 175 TYLWWINN-QSLPVS-------PRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRS 226

Query: 389 AAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEA 448
               ++V YGPD PTI+ S         +   G+N++L C AAS PPA  +W +    + 
Sbjct: 227 DPVTLNVTYGPDTPTISPSDT-------YYRPGANLSLSCYAASNPPAQYSWLINGTFQQ 279

Query: 449 AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGG--- 505
           +      L +P +   ++G+Y C A N  TG  R ++  + V +L P   +  ++     
Sbjct: 280 ST---QELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTT 336

Query: 506 -PGDR-SLRFRCS 516
             GD+ S+   CS
Sbjct: 337 VTGDKDSVNLTCS 349



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 9/81 (11%)

Query: 733 AVVPLPPRNPGTWTFRILPILGGQPGTPSQSRV-YRAGPT---LSHGAIAGIVLGSLLGL 788
           ++ P+   + GT+   +   +      P    V Y A P    LS GAIAGIV+G +  +
Sbjct: 382 SINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALPQENGLSPGAIAGIVIGVVALV 441

Query: 789 ALLAVLLLLCICCLCRFRGKT 809
           AL+AV L     C   F GKT
Sbjct: 442 ALIAVAL----ACFLHF-GKT 457


>gi|19923195 carcinoembryonic antigen-related cell adhesion molecule
           1 isoform 1 precursor [Homo sapiens]
          Length = 526

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 66/253 (26%), Positives = 114/253 (45%), Gaps = 26/253 (10%)

Query: 272 DDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGR 331
           +D G YT +VI++ +  +       VY  LP+ S+        E    +   C       
Sbjct: 115 NDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDT 174

Query: 332 GELSWSRDGRALEAAESEGAETPRMR-SEGDQLLIVRPV-RSDHARYTCRVRSPFG-HRE 388
             L W  + ++L  +       PR++ S G++ L +  V R+D   Y C +++P   +R 
Sbjct: 175 TYLWWINN-QSLPVS-------PRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRS 226

Query: 389 AAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEA 448
               ++V YGPD PTI+ S         +   G+N++L C AAS PPA  +W +    + 
Sbjct: 227 DPVTLNVTYGPDTPTISPSDT-------YYRPGANLSLSCYAASNPPAQYSWLINGTFQQ 279

Query: 449 AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGG--- 505
           +      L +P +   ++G+Y C A N  TG  R ++  + V +L P   +  ++     
Sbjct: 280 ST---QELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTT 336

Query: 506 -PGDR-SLRFRCS 516
             GD+ S+   CS
Sbjct: 337 VTGDKDSVNLTCS 349



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 9/81 (11%)

Query: 733 AVVPLPPRNPGTWTFRILPILGGQPGTPSQSRV-YRAGPT---LSHGAIAGIVLGSLLGL 788
           ++ P+   + GT+   +   +      P    V Y A P    LS GAIAGIV+G +  +
Sbjct: 382 SINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALPQENGLSPGAIAGIVIGVVALV 441

Query: 789 ALLAVLLLLCICCLCRFRGKT 809
           AL+AV L     C   F GKT
Sbjct: 442 ALIAVAL----ACFLHF-GKT 457


>gi|40255013 carcinoembryonic antigen-related cell adhesion molecule
           6 (non-specific cross reacting antigen) [Homo sapiens]
          Length = 344

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 62/227 (27%), Positives = 101/227 (44%), Gaps = 21/227 (9%)

Query: 272 DDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGR 331
           +D G YT +VI++ +  +       VY  LP+ S+        E    +   C       
Sbjct: 115 NDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNT 174

Query: 332 GELSWSRDGRALEAAESEGAETPRMR-SEGDQLLIVRPV-RSDHARYTCRVRSPFG-HRE 388
             L W  +G++L  +       PR++ S G+  L +  V R+D   Y C +++P   +R 
Sbjct: 175 TYLWWV-NGQSLPVS-------PRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRS 226

Query: 389 AAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEA 448
               ++V YGPD PTI+ S             G N+ L C AAS PPA  +W +    + 
Sbjct: 227 DPVTLNVLYGPDGPTISPSKAN-------YRPGENLNLSCHAASNPPAQYSWFINGTFQQ 279

Query: 449 AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP 495
           +      L +P +   ++G+Y C A N  TG  R ++  +TV+   P
Sbjct: 280 ST---QELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVSGSAP 323


>gi|98986445 carcinoembryonic antigen-related cell adhesion molecule
           5 preproprotein [Homo sapiens]
          Length = 702

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 21/227 (9%)

Query: 272 DDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGR 331
           +D G YT  VI++ +  +       VY  LP+ S+     +  E    +   C       
Sbjct: 115 NDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDA 174

Query: 332 GELSWSRDGRALEAAESEGAETPRMR-SEGDQLLIVRPV-RSDHARYTCRVRSPFGHREA 389
             L W  + ++L  +       PR++ S G++ L +  V R+D A Y C  ++P   R +
Sbjct: 175 TYLWWVNN-QSLPVS-------PRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRS 226

Query: 390 AADV-SVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEA 448
            + + +V YGPD PTI+  +           +G N+ L C AAS PPA  +W +    + 
Sbjct: 227 DSVILNVLYGPDAPTISPLNTS-------YRSGENLNLSCHAASNPPAQYSWFVNGTFQQ 279

Query: 449 AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP 495
           +      L +P +   ++G+Y C A N  TG  R ++  +TV   PP
Sbjct: 280 ST---QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPP 323



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 57/223 (25%), Positives = 97/223 (43%), Gaps = 22/223 (9%)

Query: 273 DAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGR 331
           ++G+YT +    A    +T   T+ V   LP+ S+     +  E    +   C       
Sbjct: 471 NSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT 530

Query: 332 GELSWSRDGRALEAAESEGAETPRMR-SEGDQLLIVRPV-RSDHARYTCRVR-SPFGHRE 388
             L W  +G++L  +       PR++ S G++ L +  V R+D   Y C ++ S   +R 
Sbjct: 531 TYLWWV-NGQSLPVS-------PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRS 582

Query: 389 AAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEA 448
               + V YGPD P I+        P     +G+N+ L C +AS P    +W +    + 
Sbjct: 583 DPVTLDVLYGPDTPIIS-------PPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQ 635

Query: 449 AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVA 491
                  L +  + P + GTYAC  +N  TGR    + ++TV+
Sbjct: 636 HTQV---LFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVS 675



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 59/244 (24%), Positives = 104/244 (42%), Gaps = 25/244 (10%)

Query: 257 FDQARGVLELASAQLDDAGVYTAEVIRAGVS-QQTHEFTVGVYEPLPQLSVQPKAPETEE 315
           F Q+   L + +  ++++G YT +   +     +T   T+ VY   P+  +        E
Sbjct: 277 FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVE 336

Query: 316 GAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQ--LLIVRPVRSDH 373
               + L C         L W  + ++L  +       PR++   D   L ++   R+D 
Sbjct: 337 DEDAVALTCEPEIQNTTYLWWVNN-QSLPVS-------PRLQLSNDNRTLTLLSVTRNDV 388

Query: 374 ARYTCRVRSPFG--HREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAA 431
             Y C +++     H +    ++V YGPD PTI+ S         +   G N++L C AA
Sbjct: 389 GPYECGIQNKLSVDHSDPVI-LNVLYGPDDPTISPSYT-------YYRPGVNLSLSCHAA 440

Query: 432 SRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV- 490
           S PPA  +W +    +        L +  +   ++G Y C A N  +G  R ++  +TV 
Sbjct: 441 SNPPAQYSWLIDGNIQQHT---QELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVS 497

Query: 491 ADLP 494
           A+LP
Sbjct: 498 AELP 501



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 22/70 (31%), Positives = 37/70 (52%), Gaps = 6/70 (8%)

Query: 728 PQERSAVV---PLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAG---PTLSHGAIAGIV 781
           PQ+ + V+    + P N GT+   +  +  G+  +  +S    A    P LS GA  GI+
Sbjct: 633 PQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIM 692

Query: 782 LGSLLGLALL 791
           +G L+G+AL+
Sbjct: 693 IGVLVGVALI 702


>gi|194328712 pregnancy specific beta-1-glycoprotein 8 isoform c
           [Homo sapiens]
          Length = 297

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 60/250 (24%), Positives = 106/250 (42%), Gaps = 23/250 (9%)

Query: 246 SLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLS 305
           SL  +HR  L+  +    L L       AG Y  E+     + ++  FT+ +   LP+  
Sbjct: 64  SLPMSHR--LQLSETNRTLFLLGVTKYTAGPYECEIRNPVSASRSDPFTLNLLPKLPKPY 121

Query: 306 VQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLI 365
           +     +  E    L   C         + W  +G++L  +       PR++   +  ++
Sbjct: 122 ITINNLKPRENKDVLNFTCEPKSENYTYIWWL-NGQSLPVS-------PRVKRPIENRIL 173

Query: 366 VRP--VRSDHARYTCRVRSPFGH-REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGS 422
           + P   R++   Y C +R  +G  R     ++V YGPD P I  S         +  +G 
Sbjct: 174 ILPSVTRNETGPYQCEIRDQYGGIRSYPVTLNVLYGPDLPRIYPSFT-------YYRSGE 226

Query: 423 NVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRR 482
            + L C+A S PPA  +W++    + +   G +L +P +   H+G YAC   N  TG+  
Sbjct: 227 VLYLSCSADSNPPAQYSWTINGKFQLS---GQKLFIPQITTKHSGLYACSVRNSATGKES 283

Query: 483 RSLLNLTVAD 492
              + + V+D
Sbjct: 284 SKSMTVKVSD 293


>gi|194328710 pregnancy specific beta-1-glycoprotein 8 isoform b
           [Homo sapiens]
          Length = 419

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 60/250 (24%), Positives = 106/250 (42%), Gaps = 23/250 (9%)

Query: 246 SLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLS 305
           SL  +HR  L+  +    L L       AG Y  E+     + ++  FT+ +   LP+  
Sbjct: 186 SLPMSHR--LQLSETNRTLFLLGVTKYTAGPYECEIRNPVSASRSDPFTLNLLPKLPKPY 243

Query: 306 VQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLI 365
           +     +  E    L   C         + W  +G++L  +       PR++   +  ++
Sbjct: 244 ITINNLKPRENKDVLNFTCEPKSENYTYIWWL-NGQSLPVS-------PRVKRPIENRIL 295

Query: 366 VRP--VRSDHARYTCRVRSPFGH-REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGS 422
           + P   R++   Y C +R  +G  R     ++V YGPD P I  S         +  +G 
Sbjct: 296 ILPSVTRNETGPYQCEIRDQYGGIRSYPVTLNVLYGPDLPRIYPSFT-------YYRSGE 348

Query: 423 NVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRR 482
            + L C+A S PPA  +W++    + +   G +L +P +   H+G YAC   N  TG+  
Sbjct: 349 VLYLSCSADSNPPAQYSWTINGKFQLS---GQKLFIPQITTKHSGLYACSVRNSATGKES 405

Query: 483 RSLLNLTVAD 492
              + + V+D
Sbjct: 406 SKSMTVKVSD 415


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 122/506 (24%), Positives = 197/506 (38%), Gaps = 76/506 (15%)

Query: 263  VLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRL 322
            +L L    ++DAG YT  V+R    ++   F + V  P   +          +    + L
Sbjct: 2441 MLRLMQTTMEDAGQYTC-VVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTL 2499

Query: 323  RCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHA-RYTCRVR 381
             C   G    E++W +DG+ L+  E+    +      G + L +  V+  H  RYTC   
Sbjct: 2500 TCEVTGNPVPEITWHKDGQPLQEDEAHHIIS------GGRFLQITNVQVPHTGRYTCLAS 2553

Query: 382  SPFGHREAAADVSVFYGPDPPTIT-VSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW 440
            SP GH+  +  ++VF  P   TI  V SD +      V   S  +L C A S PPA ITW
Sbjct: 2554 SPAGHKSRSFSLNVFVSP---TIAGVGSDGNPEDVT-VILNSPTSLVCEAYSYPPATITW 2609

Query: 441  -SLADPAEA-----AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
                 P E+      +P G  L +      +AG Y+C+A N      +   + + +   P
Sbjct: 2610 FKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYI---P 2666

Query: 495  PGAPQCSVEGGPG----------DRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVL 544
            P   +  +  GPG          + +L   C      P+ASL +    + +++     V 
Sbjct: 2667 PIINKGDL-WGPGLSPKEVKIKVNNTLTLECE-AYAIPSASLSWYKDGQPLKSD--DHVN 2722

Query: 545  LAAVPAHPRLSGVPI------TCLARHLVATR------TCTVTPEAPREVLLHPLVAETR 592
            +AA     ++    I      TC+A ++             V P   +   +  ++   R
Sbjct: 2723 IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGR 2782

Query: 593  LGEAEVAL---------EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFS 643
             GEA+  +         E +  PPP+  +W ++G PL      ++ +   GR L I    
Sbjct: 2783 NGEAKDVIINNPISLYCETNAAPPPT-LTWYKDGHPLT--SSDKVLILPGGRVLQIPRAK 2839

Query: 644  LDWDLGNYSVLCSGALGAGGDQI-----TLIGPSISSWRLQRARDAAVLTWDVERGALIS 698
            ++ D G Y+  C     AG D +      L+ P I         +  VL   V + AL  
Sbjct: 2840 VE-DAGRYT--CVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVL---VNKSAL-- 2891

Query: 699  SFEIQAWPDGPALGRTSTYRDWVSLL 724
               I+    G    R S  +D   LL
Sbjct: 2892 ---IECLSSGSPAPRNSWQKDGQPLL 2914



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 113/507 (22%), Positives = 187/507 (36%), Gaps = 76/507 (14%)

Query: 186  HSAASFPQQVGGPLAVLVGTTIRLPL-VPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPL 244
            H     P  + GP   ++  TI  P+ +     G P   + W +  K             
Sbjct: 3144 HLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK------------- 3190

Query: 245  ISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQL 304
              ++ +    +R       L++A +Q  D+G YT          Q + F + +  P    
Sbjct: 3191 -RIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYF-LSIQVPPSVA 3248

Query: 305  SVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLL 364
              +  +  +      + L C   G     + W +DG+ + + E+E     R+ + G  L 
Sbjct: 3249 GAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERI---RVSANGSTLN 3305

Query: 365  IVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNV 424
            I   + SD  +YTC   +P G  +   +++V+  P     T+  ++D A        +++
Sbjct: 3306 IYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTP-----TIRGNKDEAEKLMTLVDTSI 3360

Query: 425  TLRCAAASRPPADITW---SLADPAEAAV---PAGSRLLLPAVGPGHAGTYACLAANPRT 478
             + C A   PP  I W    L  P  + +    AG  + +          Y C+A+N R 
Sbjct: 3361 NIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN-RA 3419

Query: 479  GRRRRSLLNLTV-----ADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQF--QGL 531
            G   +   NL V      D   G  + +V  G    S    C    G PA S+ +   G 
Sbjct: 3420 GVDNKH-YNLQVFAPPNMDNSMGTEEITVLKG---SSTSMACI-TDGTPAPSMAWLRDGQ 3474

Query: 532  PEGIRAGPVSS---VLLAAVPAHPRLSGVPITCLA--------RHLVATRTCTVTPEAPR 580
            P G+ A    S   ++L  + A    SG   TC+A        +H +      + P    
Sbjct: 3475 PLGLDAHLTVSTHGMVLQLLKAETEDSG-KYTCIASNEAGEVSKHFILK---VLEPPHIN 3530

Query: 581  EVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAP-------GGGSRLRLSQD 633
                H  ++       E+   ASG P P + +W ++GRPL         GGG  LR+S  
Sbjct: 3531 GSEEHEEISVIVNNPLELTCIASGIPAP-KMTWMKDGRPLPQTDQVQTLGGGEVLRISTA 3589

Query: 634  GRKLHIGNFSLDWDLGNYSVLCSGALG 660
              +          D G Y+ L S   G
Sbjct: 3590 QVE----------DTGRYTCLASSPAG 3606



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 126/488 (25%), Positives = 181/488 (37%), Gaps = 68/488 (13%)

Query: 218  GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
            G  TS+     G+   +   L  G PL  LD     HL       VL+L  A+ +D+G Y
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL-GLDA----HLTVSTHGMVLQLLKAETEDSGKY 3504

Query: 278  TAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAE-LRLRCLGWGPGRGELSW 336
            T  +      + +  F + V EP P ++   +  E        L L C+  G    +++W
Sbjct: 3505 TC-IASNEAGEVSKHFILKVLEP-PHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW 3562

Query: 337  SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVF 396
             +DGR L   +       +    G+ L I      D  RYTC   SP G  +    V V 
Sbjct: 3563 MKDGRPLPQTDQV-----QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVH 3617

Query: 397  YGPDPPTITVSSD-RDAAPARFVTAGSNVTLRCAAASRPPADITWSL------ADPAEAA 449
                PP I  + + RD    R       VTL C + + PP  ITW        A P    
Sbjct: 3618 V---PPNIAGTDEPRDITVLR----NRQVTLECKSDAVPPPVITWLRNGERLQATPRVRI 3670

Query: 450  VPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQ---------- 499
            +  G  L +     G    Y C+A+N      R  +L + V     G PQ          
Sbjct: 3671 LSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKST 3730

Query: 500  ---CSVEGGPGDRSLRFRCSW-PGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLS 555
               C  EG P       R +W   GA  A           R   + +  L    AH   +
Sbjct: 3731 VLECIAEGVPTP-----RITWRKDGAVLAG-------NHARYSILENGFLHIQSAHVTDT 3778

Query: 556  GVPITCLARHLVAT--RTCTVTPEAPREVLLHPLVAETRLG-EAEVALEASGCPPPSRAS 612
            G    C+A +   T  R   +    P  +   P      +  +  +A EA+G P PS  +
Sbjct: 3779 G-RYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPS-IN 3836

Query: 613  WAREGRPL-APGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITL--- 668
            W + G  L      +  RL   G  L I + S+D D   Y   C+   GAG D+ T+   
Sbjct: 3837 WRKNGHLLNVDQNQNSYRLLSSG-SLVIISPSVD-DTATYE--CTVTNGAGDDKRTVDLT 3892

Query: 669  --IGPSIS 674
              + PSI+
Sbjct: 3893 VQVPPSIA 3900



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 120/500 (24%), Positives = 186/500 (37%), Gaps = 72/500 (14%)

Query: 192  PQQVGGP--LAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDP 249
            P   GGP  L +L+  +  L  +     G PT  + WR+   VLA               
Sbjct: 3713 PNIKGGPQSLVILLNKSTVLECIA---EGVPTPRITWRKDGAVLAG-------------- 3755

Query: 250  AHRDHLRFD-QARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQP 308
               +H R+     G L + SA + D G Y      A  + +     + V+ P P ++  P
Sbjct: 3756 ---NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR-RRIDLQVHVP-PSIAPGP 3810

Query: 309  KAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRP 368
                T     +  L C   G  +  ++W ++G  L   +++ +   R+ S G  L+I+ P
Sbjct: 3811 -TNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSY--RLLSSG-SLVIISP 3866

Query: 369  VRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRC 428
               D A Y C V +  G  +   D++V     PP+I      D      VT  +   + C
Sbjct: 3867 SVDDTATYECTVTNGAGDDKRTVDLTV---QVPPSIA-----DEPTDFLVTKHAPAVITC 3918

Query: 429  AAASRPPADITWSLADPAEAAVPAGSRLL------LPAVGPGHAGTYACLAANPRTGRRR 482
             A+  P   I W+           G R+L      + A    HAG Y C+A N      R
Sbjct: 3919 TASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHR 3978

Query: 483  RSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSS 542
               + L V + P   PQ S      +  +   C    G P+  + +Q   EGI     S 
Sbjct: 3979 H--VTLHVHEPPVIQPQPSELHVILNNPILLPCE-ATGTPSPFITWQ--KEGINVN-TSG 4032

Query: 543  VLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREV------LLHPLVAETRLGEA 596
               A +P+     G+ I+   R    T  C     A   +      +  P V    L E 
Sbjct: 4033 RNHAVLPS----GGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEY 4088

Query: 597  EVAL--------EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDL 648
             +A+        EA G PPP   +W ++GR +      R R+   G  L I  F    D 
Sbjct: 4089 VIAVDKPITLSCEADGLPPPD-ITWHKDGRAIVE--SIRQRVLSSG-SLQIA-FVQPGDA 4143

Query: 649  GNYSVLCSGALGAGGDQITL 668
            G+Y+ + +   G+      L
Sbjct: 4144 GHYTCMAANVAGSSSTSTKL 4163



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 102/427 (23%), Positives = 157/427 (36%), Gaps = 50/427 (11%)

Query: 262  GVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELR 321
            G L +   QL D G YT   + + V+   ++ T  V   LP +    +   T EG   + 
Sbjct: 943  GSLHIERVQLQDGGEYTC--VASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIP-VT 999

Query: 322  LRCLGWGPGRGELSWSRDGRALEAAE---SEGAETPRMRSEGDQLLIVRPVRSDHARYTC 378
            L C   G  +  + WS+ G  +  +    S GA+          L +V P   +   Y C
Sbjct: 1000 LPCKASGNPKPSVIWSKKGELISTSSAKFSAGAD--------GSLYVVSPGGEESGEYVC 1051

Query: 379  RVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADI 438
               +  G+ +    ++V+  P          +D      V AG  VTL C   S PP  I
Sbjct: 1052 TATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII 1111

Query: 439  TW-------SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV- 490
            TW       S   P    +P+GS + +       +G Y C+A N      +   LN+ V 
Sbjct: 1112 TWAKETQLISPFSPRHTFLPSGS-MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170

Query: 491  ADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQG----LPEGIRAGPVSSVLLA 546
              +  G     V+ G   + +   C+  G         +G    L +G          L+
Sbjct: 1171 PKIQRGPKHLKVQVG---QRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLS 1227

Query: 547  AVPAHPRLSGVPITCLARHLVATRTCTVT-----------PEAPREVLLHPLVAETRLGE 595
               A P  +G+  TC+A ++  T    +T            E P        VA  R+  
Sbjct: 1228 IDQATPSDAGI-YTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRI-- 1284

Query: 596  AEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLC 655
             E    A G P P+   W   GR L  G    + + +DG  L I + +  +D G Y  +C
Sbjct: 1285 -EFPCPAKGTPKPT-IKWLHNGRELT-GREPGISILEDGTLLVIASVT-PYDNGEY--IC 1338

Query: 656  SGALGAG 662
                 AG
Sbjct: 1339 VAVNEAG 1345



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 79/313 (25%), Positives = 126/313 (40%), Gaps = 38/313 (12%)

Query: 214  IPNPGP-PTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGV--------L 264
            I N G  PT ++V R  S  L     G   P ++     +D     +A+GV        L
Sbjct: 2292 ITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTW---MKDGHPLIKAKGVEILDEGHIL 2348

Query: 265  ELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAE--LR 321
            +L +  + D G Y    +  AG++ + ++ +V  + P P +    ++PE      +  + 
Sbjct: 2349 QLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSV--HAP-PSIIGNHRSPENISVVEKNSVS 2405

Query: 322  LRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVR 381
            L C   G     ++W +DG  +  + S      R+ S G  L +++    D  +YTC VR
Sbjct: 2406 LTCEASGIPLPSITWFKDGWPVSLSNSV-----RILSGGRMLRLMQTTMEDAGQYTCVVR 2460

Query: 382  SPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS 441
            +  G       +SV     PP I   +  +      V    +VTL C     P  +ITW 
Sbjct: 2461 NAAGEERKIFGLSVLV---PPHIVGENTLEDVK---VKEKQSVTLTCEVTGNPVPEITWH 2514

Query: 442  L------ADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP 495
                    D A   +  G  L +  V   H G Y CLA++P   + R   LN+ V+   P
Sbjct: 2515 KDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS---P 2571

Query: 496  GAPQCSVEGGPGD 508
                   +G P D
Sbjct: 2572 TIAGVGSDGNPED 2584



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 106/479 (22%), Positives = 172/479 (35%), Gaps = 84/479 (17%)

Query: 238  LGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTV- 295
            L  G PL+      +  L   + R VL++  AQ+ D G YT E    AG +++ +   + 
Sbjct: 2138 LKDGHPLLK-----KPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192

Query: 296  -----GVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEG 350
                 G  + L QL+V        EG   + L C   G     L W + G  +   +S G
Sbjct: 2193 VPPNIGGSDELTQLTVI-------EGNL-ISLLCESSGIPPPNLIWKKKGSPV-LTDSMG 2243

Query: 351  AETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDR 410
                R+ S G QL I    +SD A Y+C   +  G  +   ++ V+  P     T+++  
Sbjct: 2244 RV--RILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRP-----TITNSG 2296

Query: 411  DAAPARFVTAGSNVTLRCAAASRPPADITWS------LADPAEAAVPAGSRLLLPAVGPG 464
                   VT G +++L C     PP  +TW       +       +  G  L L  +   
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS 2356

Query: 465  HAGTYACLAAN----------------PRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGD 508
              G Y C+A N                P      RS  N++V +    +  C   G P  
Sbjct: 2357 DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLP 2416

Query: 509  RSLRFRCSWP----------GGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVP 558
                F+  WP           G     L    + +   AG  + V+  A     ++ G+ 
Sbjct: 2417 SITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMED---AGQYTCVVRNAAGEERKIFGLS 2473

Query: 559  ITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGR 618
            +  +  H+V   T        ++                +  E +G P P   +W ++G+
Sbjct: 2474 V-LVPPHIVGENTLEDVKVKEKQ-------------SVTLTCEVTGNPVP-EITWHKDGQ 2518

Query: 619  PLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITL---IGPSIS 674
            PL         +   GR L I N  +    G Y+ L S   G      +L   + P+I+
Sbjct: 2519 PLQEDEAH--HIISGGRFLQITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPTIA 2574



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 103/475 (21%), Positives = 182/475 (38%), Gaps = 41/475 (8%)

Query: 210  PLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHR-----DHLRFDQARGVL 264
            P++   N   P  + V    S ++     G  AP  S     +     DH +F     +L
Sbjct: 2869 PIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRIL 2928

Query: 265  ELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAE-LRLR 323
            ++ + Q+ D G Y         S + + F + V+  +P   + PK+          + L 
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKY-FNLNVH--VPPSVIGPKSENLTVVVNNFISLT 2985

Query: 324  CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSP 383
            C   G    +LSW ++ + ++   +       +   G  L I+R   SD   YTC   + 
Sbjct: 2986 CEVSGFPPPDLSWLKNEQPIKLNTNT-----LIVPGGRTLQIIRAKVSDGGEYTCIAINQ 3040

Query: 384  FGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW--- 440
             G  +    ++V+    PP+I    D ++     V  G++V+L C + + PP  ITW   
Sbjct: 3041 AGESKKKFSLTVYV---PPSIK-DHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKN 3096

Query: 441  --SLADPAEAAVPA-GSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPG- 496
               + +     + A G  L +        G Y C A N      +   LN+ V   PP  
Sbjct: 3097 GRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYV---PPSI 3153

Query: 497  -APQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQG-----LPEGIRAGPVSSVLLAAVPA 550
              P+  V        +   C   G  P      +        + +    +S      +  
Sbjct: 3154 EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIAR 3213

Query: 551  HPRLSGVPITCLARHL--VATRTCTVTPEAPREVLLHPLVAETR--LGE-AEVALEASGC 605
                     TC+A ++   A +   ++ + P  V    + ++    LGE  E+   A+G 
Sbjct: 3214 SQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGI 3273

Query: 606  PPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
            P P    W ++G+P+A G   R+R+S +G  L+I   +L  D G Y+ + +   G
Sbjct: 3274 PTP-LIQWLKDGKPIASGETERIRVSANGSTLNIYG-ALTSDTGKYTCVATNPAG 3326



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 60/229 (26%), Positives = 94/229 (41%), Gaps = 22/229 (9%)

Query: 264 LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLR 323
           L++A   L D G Y    + +  + +   F   V EP P + V      T    A L   
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTF-FDVSEPPPVIQVPNNVTVTPGERAVLT-- 540

Query: 324 CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVR-SDHARYTCRVRS 382
           CL        L+W R+ R +  AE       R+R+  +  L ++ V+ +D   Y C V S
Sbjct: 541 CLIISAVDYNLTWQRNDRDVRLAEPA-----RIRTLANLSLELKSVKFNDAGEYHCMVSS 595

Query: 383 PFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL 442
             G   A+  ++V    +PP +TV     +      T GS V++ C+A   P   I W++
Sbjct: 596 EGGSSAASVFLTV---QEPPKVTVMPKNQS-----FTGGSEVSIMCSATGYPKPKIAWTV 647

Query: 443 AD-----PAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLL 486
            D          + +   L +    P  AG Y CLA+N     ++ S L
Sbjct: 648 NDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 104/446 (23%), Positives = 172/446 (38%), Gaps = 41/446 (9%)

Query: 241  GAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEP 300
            G PL   DP    ++       VL L +A+ +D G Y   V  A   +Q  +  + +Y P
Sbjct: 1491 GKPLFLGDP----NVELLDRGQVLHLKNARRNDKGRYQCTVSNAA-GKQAKDIKLTIYIP 1545

Query: 301  LPQLSVQPKAPETEEGA---AELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMR 357
                S++     T+      + ++L C   G     ++W +DG+ + ++           
Sbjct: 1546 P---SIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQA-----LYI 1597

Query: 358  SEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARF 417
             +G  L I R   SD A YTC V +  G  E +  V V+  P      +  +      + 
Sbjct: 1598 DKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP-----MIEGNLATPLNKQ 1652

Query: 418  VTAGSNVTLRCAAASRPPADITWSLAD--PAEA-----AVPAGSRLLLPAVGPGHAGTYA 470
            V    ++TL C AA  P   +TW L D  P +A         G +L + +      G Y 
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTW-LKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711

Query: 471  CLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQG 530
            C+A +    +  +  +++ V     G  + S      +  L   C   G  P   +  + 
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771

Query: 531  LPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAE 590
              + I       +LL         + V  T L R + A        E    V + P +  
Sbjct: 1772 -GQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKS 1830

Query: 591  TRLGE------AEVALE--ASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNF 642
            + L E        VAL+  A+G P PS  +W ++ +P+    G+ L++   GR L I   
Sbjct: 1831 SGLSERVVVKYKPVALQCIANGIPNPS-ITWLKDDQPVNTAQGN-LKIQSSGRVLQIAKT 1888

Query: 643  SLDWDLGNYSVLCSGALGAGGDQITL 668
             L+ D G Y+ + + A G     I L
Sbjct: 1889 LLE-DAGRYTCVATNAAGETQQHIQL 1913



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 100/490 (20%), Positives = 180/490 (36%), Gaps = 81/490 (16%)

Query: 201  VLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQA 260
            VLV   ++L      NP P   ++ W + +++L+                    + F   
Sbjct: 1932 VLVSNPVQLECKAAGNPVP---VITWYKDNRLLSGS----------------TSMTFLNR 1972

Query: 261  RGVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAA- 318
              ++++ SAQ+ DAG+Y    I  AG ++  +           Q+ V P    +    A 
Sbjct: 1973 GQIIDIESAQISDAGIYKCVAINSAGATELFYSL---------QVHVAPSISGSNNMVAV 2023

Query: 319  ----ELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHA 374
                 +RL C   G     L+W +DG  + ++ S G +   + S G  L +     SD  
Sbjct: 2024 VVNNPVRLECEARGIPAPSLTWLKDGSPV-SSFSNGLQ---VLSGGRILALTSAQISDTG 2079

Query: 375  RYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
            RYTC   +  G ++   D+ V+    PP I +  +++ +    V     V L C + + P
Sbjct: 2080 RYTCVAVNAAGEKQRDIDLRVYV---PPNI-MGEEQNVS----VLISQAVELLCQSDAIP 2131

Query: 435  PADITW------SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNL 488
            P  +TW       L  P  +     S L +        G Y C A N      +   +N+
Sbjct: 2132 PPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNI 2191

Query: 489  TVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAA- 547
             V     G+ + +         +   C    G P  +L ++     +    +  V + + 
Sbjct: 2192 WVPPNIGGSDELTQLTVIEGNLISLLCE-SSGIPPPNLIWKKKGSPVLTDSMGRVRILSG 2250

Query: 548  -----VPAHPRLSGVPITCLARHLVATR------------TCTVTPEAPREVLLHPLVAE 590
                 +    +      +C+A ++  T             T T +   P E+++      
Sbjct: 2251 GRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIV------ 2304

Query: 591  TRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGN 650
            TR     +  E  G PPP+  +W ++G PL    G  + +  +G  L + N  +  D G 
Sbjct: 2305 TRGKSISLECEVQGIPPPT-VTWMKDGHPLIKAKG--VEILDEGHILQLKNIHVS-DTGR 2360

Query: 651  YSVLCSGALG 660
            Y  +     G
Sbjct: 2361 YVCVAVNVAG 2370



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 115/510 (22%), Positives = 197/510 (38%), Gaps = 63/510 (12%)

Query: 173  SAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKV 232
            SA + E  +S + H A S        +AV+V   +RL       P P    + W      
Sbjct: 1996 SAGATELFYSLQVHVAPSISGS-NNMVAVVVNNPVRLECEARGIPAPS---LTW------ 2045

Query: 233  LAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHE 292
                 L  G+P+ S      + L+      +L L SAQ+ D G YT   + A   +Q  +
Sbjct: 2046 -----LKDGSPVSSFS----NGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQ-RD 2095

Query: 293  FTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAE 352
              + VY P   +  +         A EL  +     P    L+W +DG  L   +  G  
Sbjct: 2096 IDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP--PTLTWLKDGHPL--LKKPGLS 2151

Query: 353  TPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDA 412
                RS    L I      D  RYTC   +  G  E   +V+++    PP I  S   D 
Sbjct: 2152 ISENRS---VLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWV---PPNIGGS---DE 2202

Query: 413  APARFVTAGSNVTLRCAAASRPPADITWS------LADPAEAA--VPAGSRLLLPAVGPG 464
                 V  G+ ++L C ++  PP ++ W       L D       +  G +L +      
Sbjct: 2203 LTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKS 2262

Query: 465  HAGTYACLAAN-PRTGRRRRSL---LNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGG 520
             A  Y+C+A+N   T ++  +L   +  T+ +      +  V  G   +S+   C   G 
Sbjct: 2263 DAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRG---KSISLECEVQGI 2319

Query: 521  APAASLQFQGLPEGIRAGPVSSV----LLAAVPAHPRLSGVPITCLARHL--VATRTCTV 574
             P      +     I+A  V  +    +L     H   +G    C+A ++  +  +   +
Sbjct: 2320 PPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTG-RYVCVAVNVAGMTDKKYDL 2378

Query: 575  TPEAPREVLLH----PLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRL 630
            +  AP  ++ +      ++        +  EASG P PS  +W ++G P++    + +R+
Sbjct: 2379 SVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPS-ITWFKDGWPVSL--SNSVRI 2435

Query: 631  SQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
               GR L +   +++ D G Y+ +   A G
Sbjct: 2436 LSGGRMLRLMQTTME-DAGQYTCVVRNAAG 2464



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 94/420 (22%), Positives = 156/420 (37%), Gaps = 51/420 (12%)

Query: 264  LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLR 323
            L +A AQ+ + G+Y              EF V V+ P P +     +         + L+
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTA-GDHKKEFEVTVHVP-PTIKSSGLSERVVVKYKPVALQ 1847

Query: 324  CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSP 383
            C+  G     ++W +D + +  A+       +++S G  L I + +  D  RYTC   + 
Sbjct: 1848 CIANGIPNPSITWLKDDQPVNTAQGN----LKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903

Query: 384  FGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW--- 440
             G  +    + V    +PP++    D        V   + V L C AA  P   ITW   
Sbjct: 1904 AGETQQHIQLHVH---EPPSL---EDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKD 1957

Query: 441  ---SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGA 497
                    +   +  G  + + +     AG Y C+A N          L + VA  P  +
Sbjct: 1958 NRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVA--PSIS 2015

Query: 498  PQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGV 557
               ++     +  +R  C    G PA SL +  L +G      S+ L         LSG 
Sbjct: 2016 GSNNMVAVVVNNPVRLECE-ARGIPAPSLTW--LKDGSPVSSFSNGLQV-------LSGG 2065

Query: 558  PITCLARHLVATR---TC---TVTPEAPREVLLHPLVAETRLGE-----------AEVAL 600
             I  L    ++     TC       E  R++ L   V    +GE            E+  
Sbjct: 2066 RILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLC 2125

Query: 601  EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
            ++   PPP+  +W ++G PL    G  L +S++   L I +  +  D G Y+   +   G
Sbjct: 2126 QSDAIPPPT-LTWLKDGHPLLKKPG--LSISENRSVLKIEDAQVQ-DTGRYTCEATNVAG 2181



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 107/500 (21%), Positives = 185/500 (37%), Gaps = 65/500 (13%)

Query: 199  LAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFD 258
            ++VL G  + LP      P P   ++ W + +++++     P +P  +  P+        
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPP---IITWAKETQLIS-----PFSPRHTFLPS-------- 1132

Query: 259  QARGVLELASAQLDDAGVY--TAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEG 316
               G +++   +  D+G+Y   A  I   V+Q      + V+ P P++   PK  + + G
Sbjct: 1133 ---GSMKITETRTSDSGMYLCVATNIAGNVTQAVK---LNVHVP-PKIQRGPKHLKVQVG 1185

Query: 317  AAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARY 376
               + + C   G     ++WS+ G  +          P        L I +   SD   Y
Sbjct: 1186 Q-RVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNP-----DGTLSIDQATPSDAGIY 1239

Query: 377  TCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPA 436
            TC   +  G  E    + V    +PPT+           +   A   +   C A   P  
Sbjct: 1240 TCVATNIAGTDETEITLHV---QEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKP 1296

Query: 437  DITW-------SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLT 489
             I W       +  +P  + +  G+ L++ +V P   G Y C+A N      R+  L + 
Sbjct: 1297 TIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVH 1356

Query: 490  VADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSV----LL 545
            V  +     Q +      ++     C   G      + ++   +   +  + +V    +L
Sbjct: 1357 VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKIL 1416

Query: 546  AAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLG-------EAEV 598
                A P  +G   +C A ++  T           +VL+ P +  T            +V
Sbjct: 1417 KLFRATPEDAG-RYSCKAINIAGTSQKYFN----IDVLVPPTIIGTNFPNEVSVVLNRDV 1471

Query: 599  ALE--ASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCS 656
            ALE    G P P    W ++G+PL   G   + L   G+ LH+ N   + D G Y    S
Sbjct: 1472 ALECQVKGTPFPD-IHWFKDGKPLFL-GDPNVELLDRGQVLHLKNARRN-DKGRYQCTVS 1528

Query: 657  GALGAGGDQITL---IGPSI 673
             A G     I L   I PSI
Sbjct: 1529 NAAGKQAKDIKLTIYIPPSI 1548



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 67/274 (24%), Positives = 104/274 (37%), Gaps = 31/274 (11%)

Query: 220  PTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTA 279
            PTSLV                G PL S       ++R       L++ +AQ D+AG Y+ 
Sbjct: 2592 PTSLVCEAYSYPPATITWFKDGTPLES-----NRNIRILPGGRTLQILNAQEDNAGRYSC 2646

Query: 280  EVIRAGVSQQTHEFTVGVYEP-------LPQLSVQPKAPETEEGAAELRLRCLGWGPGRG 332
             V      +    + V VY P       L    + PK  + +     L L C  +     
Sbjct: 2647 -VATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNT-LTLECEAYAIPSA 2704

Query: 333  ELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAAD 392
             LSW +DG+ L++ +        + + G  L I     SD  RYTC   +  G  E   D
Sbjct: 2705 SLSWYKDGQPLKSDDHVN-----IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFD 2759

Query: 393  VSVFYGPDPPTI-----TVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS------ 441
            V++   P    +      + + R+   A+ V   + ++L C   + PP  +TW       
Sbjct: 2760 VNIQVPPSFQKLWEIGNMLDTGRNGE-AKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818

Query: 442  LADPAEAAVPAGSRLLLPAVGPGHAGTYACLAAN 475
             +      +P G  L +P      AG Y C+A N
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVN 2852



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 120/517 (23%), Positives = 193/517 (37%), Gaps = 71/517 (13%)

Query: 173  SAQSPESKFSAETHSAASF-PQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSK 231
            +A +   +   + H   S  P      + V V TT+      IP P      + WR+   
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPS-----INWRKNGH 3842

Query: 232  VLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIR-AGVSQQT 290
            +L          L+S               G L + S  +DD   Y   V   AG  ++T
Sbjct: 3843 LLNVDQNQNSYRLLS--------------SGSLVIISPSVDDTATYECTVTNGAGDDKRT 3888

Query: 291  HEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEG 350
             + TV V    P ++ +P      + A  + + C   G     + W+++G  L     +G
Sbjct: 3889 VDLTVQVP---PSIADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWTKNGIRL-LPRGDG 3943

Query: 351  AETPRMRSEGDQLLIVRPVRSDHA-RYTCRVRSPFG--HREAAADVSVFYGPDPPTITVS 407
                R+ S G   + +   + +HA RYTC  R+  G  HR     V      +PP I   
Sbjct: 3944 Y---RILSSG--AIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVH-----EPPVIQPQ 3993

Query: 408  SDRDAAPARFVTAGSNVTLRCAAASRPPADITW-------SLADPAEAAVPAGSRLLLPA 460
                      V   + + L C A   P   ITW       + +    A +P+G   +  A
Sbjct: 3994 PSE-----LHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRA 4048

Query: 461  VGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGG 520
            V    AGTY C+A NP      +  LN+ V   P  +P         D+ +   C    G
Sbjct: 4049 VRED-AGTYMCVAQNPAGTALGKIKLNVQVP--PVISPHLKEYVIAVDKPITLSCE-ADG 4104

Query: 521  APAASLQF----QGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHL-----VATRT 571
             P   + +    + + E IR   +SS  L      P  +G   TC+A ++      +T+ 
Sbjct: 4105 LPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAG-HYTCMAANVAGSSSTSTKL 4163

Query: 572  CTVTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLS 631
                P   R    H  V E    +A +   A G P P+  +W ++   LA   G     +
Sbjct: 4164 TVHVPPRIRSTEGHYTVNEN--SQAILPCVADGIPTPA-INWKKDNVLLANLLGK--YTA 4218

Query: 632  QDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITL 668
            +   +L + N  L+ D G Y+ + + A G     ++L
Sbjct: 4219 EPYGELILENVVLE-DSGFYTCVANNAAGEDTHTVSL 4254



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 55/218 (25%), Positives = 87/218 (39%), Gaps = 23/218 (10%)

Query: 264 LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLR 323
           LEL S + +DAG Y   V   G S     F   V EP P+++V PK  ++  G +E+ + 
Sbjct: 576 LELKSVKFNDAGEYHCMVSSEGGSSAASVFLT-VQEP-PKVTVMPKN-QSFTGGSEVSIM 632

Query: 324 CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSP 383
           C   G  + +++W+ +   +      G+   RM S+G  L I      D   Y C   + 
Sbjct: 633 CSATGYPKPKIAWTVNDMFIV-----GSHRYRMTSDGT-LFIKNAAPKDAGIYGCLASNS 686

Query: 384 FGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLA 443
            G  +  + +   Y   P  + V S+        V  G    + C  +  PP  + W   
Sbjct: 687 AGTDKQNSTLR--YIEAPKLMVVQSEL------LVALGDITVMECKTSGIPPPQVKWFKG 738

Query: 444 D----PAEAAV--PAGSRLLLPAVGPGHAGTYACLAAN 475
           D    P+   +  P    L +       AG Y C+A N
Sbjct: 739 DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAIN 776



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 114/548 (20%), Positives = 192/548 (35%), Gaps = 102/548 (18%)

Query: 166  DDMDLKLSAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVV 225
            D+ ++ L  Q P +    E     +F ++V                 P P  G P   + 
Sbjct: 1250 DETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEF----------PCPAKGTPKPTIK 1299

Query: 226  WRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIR-A 284
            W    + L   G  PG  ++             +   +L +AS    D G Y    +  A
Sbjct: 1300 WLHNGRELT--GREPGISIL-------------EDGTLLVIASVTPYDNGEYICVAVNEA 1344

Query: 285  GVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAEL-RLRCLGWGPGRGELSWSRDGRAL 343
            G +++ +   V V    P +  + +         +L  L C   G     + W +D   +
Sbjct: 1345 GTTERKYNLKVHVP---PVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN--V 1399

Query: 344  EAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPT 403
            +  ES   +T    + G  L + R    D  RY+C+  +  G  +   ++ V     PPT
Sbjct: 1400 QVTESSTIQTV---NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLV---PPT 1453

Query: 404  ITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW-------SLADPAEAAVPAGSRL 456
            I  ++  +      V    +V L C     P  DI W        L DP    +  G  L
Sbjct: 1454 IIGTNFPNEVS---VVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVL 1510

Query: 457  LLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPG--------D 508
             L        G Y C  +N   G++ +  + LT+  +PP     S++GG          +
Sbjct: 1511 HLKNARRNDKGRYQCTVSN-AAGKQAKD-IKLTIY-IPP-----SIKGGNVTTDISVLIN 1562

Query: 509  RSLRFRCSWPG-GAPAASLQFQGLP--EGIRAGPVSSVLLAAVPAHPRLSGVPITCLARH 565
              ++  C   G   PA +    G P     +A  +       +P          TC   +
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVAN 1622

Query: 566  LVATRTCT---------------VTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSR 610
            +  T   +                TP   + V+ H L  E +         A+G P P  
Sbjct: 1623 VAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECK---------AAGNPSPI- 1672

Query: 611  ASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQI---- 666
             +W ++G P+       +R+   G+KL I + + + D G Y  +C     AG  +I    
Sbjct: 1673 LTWLKDGVPVK--ANDNIRIEAGGKKLEIMS-AQEIDRGQY--ICVATSVAGEKEIKYEV 1727

Query: 667  -TLIGPSI 673
              L+ P+I
Sbjct: 1728 DVLVPPAI 1735



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 89/375 (23%), Positives = 147/375 (39%), Gaps = 39/375 (10%)

Query: 262  GVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAEL 320
            G L++A  Q  DAG YT      AG S  + + TV V    P      +   T    ++ 
Sbjct: 4131 GSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV----PPRIRSTEGHYTVNENSQA 4186

Query: 321  RLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRV 380
             L C+  G     ++W +D   L  A   G  T     E   L++   V  D   YTC  
Sbjct: 4187 ILPCVADGIPTPAINWKKDNVLL--ANLLGKYTAEPYGE---LILENVVLEDSGFYTCVA 4241

Query: 381  RSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW 440
             +  G       ++V      PT T     +      +  G  + L C A   P   +TW
Sbjct: 4242 NNAAGEDTHTVSLTVHV---LPTFT-----ELPGDVSLNKGEQLRLSCKATGIPLPKLTW 4293

Query: 441  SLAD---PAEA-AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPG 496
            +  +   PA   +V   S L++  V    +GTY C A N     +    + +    +  G
Sbjct: 4294 TFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKG 4353

Query: 497  -APQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGI----RAGPVSSVLLAAVPAH 551
              P   +E   G+  L        G P  ++Q+      I    R   + +  LA     
Sbjct: 4354 DYPSNWIEPLGGNAILNCEVK---GDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTV 4410

Query: 552  PRLSGVPITCLARHL--VATRTCTVTPEAPREVLLHPLVAETRL---GEAEVALEASGCP 606
               +G   TC+A +   V  R+ ++T ++P  + L P+  ET +   G+  +  +A+G P
Sbjct: 4411 NEDAG-DYTCVATNEAGVVERSMSLTLQSPPIITLEPV--ETVINAGGKIILNCQATGEP 4467

Query: 607  PPSRASWAREGRPLA 621
             P+  +W+R+G  ++
Sbjct: 4468 QPT-ITWSRQGHSIS 4481



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 98/448 (21%), Positives = 149/448 (33%), Gaps = 63/448 (14%)

Query: 253  DHLRFDQARGVLELASAQLDDAGVYTAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAP 311
            DH+        L++  AQ+ D G YT      AG  +   +  + V     +L       
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNML 2778

Query: 312  ET-EEGAAE-------LRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQL 363
            +T   G A+       + L C         L+W +DG  L +++        +   G  L
Sbjct: 2779 DTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKV-----LILPGGRVL 2833

Query: 364  LIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSN 423
             I R    D  RYTC   +  G      DV V      P I   ++ D      V    +
Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLV----PPIIKGANSDLPEEVTVLVNKS 2889

Query: 424  VTLRCAAASRPPADITWS------LADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPR 477
              + C ++  P    +W       L D     +  G  L +        G Y C+A N  
Sbjct: 2890 ALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949

Query: 478  TGRRRRSLLNLTVADLPPGAPQ--------------CSVEGGPGDRSLRFRCSWPGGAPA 523
               ++   LN+ V     G                 C V G P         SW      
Sbjct: 2950 GSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPP-----DLSWLKNEQP 3004

Query: 524  ASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHLV--ATRTCTVTPEAPRE 581
              L    L   +  G    ++ A V       G   TC+A +    + +  ++T   P  
Sbjct: 3005 IKLNTNTLI--VPGGRTLQIIRAKVS-----DGGEYTCIAINQAGESKKKFSLTVYVPPS 3057

Query: 582  VLLHP----LVAETRLGEAEVALEA-SGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRK 636
            +  H      V   R G   V+LE  S   PP   +W + GR +     + + +  DG+ 
Sbjct: 3058 IKDHDSESLSVVNVREG-TSVSLECESNAVPPPVITWYKNGRMITE--STHVEILADGQM 3114

Query: 637  LHIGNFSLDWDLGNYSVLCSGALGAGGD 664
            LHI    +  D G Y  +C     AG D
Sbjct: 3115 LHIKKAEVS-DTGQY--VCRAINVAGRD 3139



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 56/228 (24%), Positives = 86/228 (37%), Gaps = 18/228 (7%)

Query: 255 LRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETE 314
           L  D   G+L++   Q  DAG YT   I     + T + T+ V  P   + +Q  A  + 
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEA-GRATGKITLDVGSP--PVFIQEPADVSM 804

Query: 315 EGAAELRLRCLGWGPGRGELSWSR-DGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDH 373
           E  + + L C   G     + W R D   + +     +   ++R+    L I+    SD 
Sbjct: 805 EIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA--LFILNLWASDK 862

Query: 374 ARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCA-AAS 432
             Y C   + FG  ++   V+V  G   P I +S          V  G  +TL C   A 
Sbjct: 863 GTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPS-----VANVIEGQQLTLPCTLLAG 916

Query: 433 RPPADITW-----SLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAAN 475
            P  +  W      L       V +   L +  V     G Y C+A+N
Sbjct: 917 NPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASN 964



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 51/196 (26%), Positives = 72/196 (36%), Gaps = 25/196 (12%)

Query: 249  PAHRDHLRFDQARGVLELASAQL--DDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSV 306
            PAH     FD   G  EL   ++  +D+G Y      +    +   F V V EP P    
Sbjct: 4301 PAH-----FDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGF-VYVKEP-PVFKG 4353

Query: 307  QPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGD-QLLI 365
               +   E       L C   G     + W+R G  +E +        R+R  G+  L I
Sbjct: 4354 DYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISH-------RIRQLGNGSLAI 4406

Query: 366  VRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVT 425
               V  D   YTC   +  G  E +  +++     PP IT+           + AG  + 
Sbjct: 4407 YGTVNEDAGDYTCVATNEAGVVERSMSLTL---QSPPIITLEPVETV-----INAGGKII 4458

Query: 426  LRCAAASRPPADITWS 441
            L C A   P   ITWS
Sbjct: 4459 LNCQATGEPQPTITWS 4474



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 5/78 (6%)

Query: 601  EASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALG 660
            E+SG PPP+   W ++G P+      R+R+   GR+L I + +   D   YS + S   G
Sbjct: 2219 ESSGIPPPNLI-WKKKGSPVLTDSMGRVRILSGGRQLQI-SIAEKSDAALYSCVASNVAG 2276

Query: 661  AGGDQITL---IGPSISS 675
                +  L   I P+I++
Sbjct: 2277 TAKKEYNLQVYIRPTITN 2294



 Score = 31.2 bits (69), Expect = 4.3
 Identities = 34/169 (20%), Positives = 63/169 (37%), Gaps = 28/169 (16%)

Query: 218  GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
            G PT  + W R                + ++ +HR         G L +     +DAG Y
Sbjct: 4375 GDPTPTIQWNRKG--------------VDIEISHRIR---QLGNGSLAIYGTVNEDAGDY 4417

Query: 278  TAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSW 336
            T      AGV +++   T+   +  P ++++P       G  ++ L C   G  +  ++W
Sbjct: 4418 TCVATNEAGVVERSMSLTL---QSPPIITLEPVETVINAGG-KIILNCQATGEPQPTITW 4473

Query: 337  SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFG 385
            SR G ++   +             + L I    + D + + C  R+  G
Sbjct: 4474 SRQGHSISWDDRVNV------LSNNSLYIADAQKEDTSEFECVARNLMG 4516


>gi|164663836 pregnancy specific beta-1-glycoprotein 11 isoform 1
           [Homo sapiens]
          Length = 335

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 67/230 (29%), Positives = 99/230 (43%), Gaps = 24/230 (10%)

Query: 272 DDAGVYTAEVIRAGVSQQ--THEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP 329
           +DAG YT  +I+ G   +  T  FT  +Y   P+ S+        E    + L C    P
Sbjct: 115 EDAGSYTLHIIKRGDGTRGVTGYFTFTLYLETPKPSISSSNLNPREAMETVILTCNPETP 174

Query: 330 GRGELSWSRDGRALEAAESEGAETPRMR-SEGDQLLIVRPVRSDHAR-YTCRV-RSPFGH 386
               L W  +G++L         T RM+ SE ++ L +  V    A  Y C +  S    
Sbjct: 175 DASYLWWM-NGQSLPM-------THRMQLSETNRTLFLFGVTKYTAGPYECEIWNSGSAS 226

Query: 387 REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPA 446
           R     +++ +GPD P I  S            +G N+ L C A S PPA  +W++    
Sbjct: 227 RSDPVTLNLLHGPDLPRIFPS-------VTSYYSGENLDLSCFANSNPPAQYSWTINGKF 279

Query: 447 EAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPG 496
           + +   G +L +P + P H G YAC A N  TG    + L + V   PPG
Sbjct: 280 QLS---GQKLFIPQITPKHNGLYACSARNSATGEESSTSLTIRVI-APPG 325


>gi|194097369 pregnancy specific beta-1-glycoprotein 5 [Homo
           sapiens]
          Length = 335

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 57/225 (25%), Positives = 97/225 (43%), Gaps = 23/225 (10%)

Query: 272 DDAGVYTAEVIRAGVSQQ--THEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP 329
           +DAG YT  +I+ G   +  T  FT  +Y  LP+  +     +  E    L   C     
Sbjct: 115 EDAGSYTLHIIKRGDRTRGVTGYFTFNLYLKLPKPYITINNSKPRENKDVLAFTCEPKSE 174

Query: 330 GRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRP--VRSDHARYTCRVRS-PFGH 386
               + W  +G++L  +       PR++   +  +++ P   R++   Y C +R    G 
Sbjct: 175 NYTYIWWL-NGQSLPVS-------PRVKRPIENRILILPSVTRNETGPYECEIRDRDGGM 226

Query: 387 REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPA 446
           R     ++V YGPD P+I  S         +  +G N+ L C A S PPA+  W++    
Sbjct: 227 RSDPVTLNVLYGPDLPSIYPSFT-------YYRSGENLYLSCFAESNPPAEYFWTINGKF 279

Query: 447 EAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVA 491
           + +   G +L +P +   H G Y C   N  TG+     + + V+
Sbjct: 280 QQS---GQKLSIPQITTKHRGLYTCSVRNSATGKESSKSMTVEVS 321


>gi|194097367 pregnancy specific beta-1-glycoprotein 5 [Homo
           sapiens]
          Length = 335

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 57/225 (25%), Positives = 97/225 (43%), Gaps = 23/225 (10%)

Query: 272 DDAGVYTAEVIRAGVSQQ--THEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP 329
           +DAG YT  +I+ G   +  T  FT  +Y  LP+  +     +  E    L   C     
Sbjct: 115 EDAGSYTLHIIKRGDRTRGVTGYFTFNLYLKLPKPYITINNSKPRENKDVLAFTCEPKSE 174

Query: 330 GRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRP--VRSDHARYTCRVRS-PFGH 386
               + W  +G++L  +       PR++   +  +++ P   R++   Y C +R    G 
Sbjct: 175 NYTYIWWL-NGQSLPVS-------PRVKRPIENRILILPSVTRNETGPYECEIRDRDGGM 226

Query: 387 REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPA 446
           R     ++V YGPD P+I  S         +  +G N+ L C A S PPA+  W++    
Sbjct: 227 RSDPVTLNVLYGPDLPSIYPSFT-------YYRSGENLYLSCFAESNPPAEYFWTINGKF 279

Query: 447 EAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVA 491
           + +   G +L +P +   H G Y C   N  TG+     + + V+
Sbjct: 280 QQS---GQKLSIPQITTKHRGLYTCSVRNSATGKESSKSMTVEVS 321


>gi|51510887 pregnancy specific beta-1-glycoprotein 8 isoform a
           [Homo sapiens]
          Length = 426

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 59/249 (23%), Positives = 105/249 (42%), Gaps = 23/249 (9%)

Query: 246 SLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLS 305
           SL  +HR  L+  +    L L       AG Y  E+     + ++  FT+ +   LP+  
Sbjct: 186 SLPMSHR--LQLSETNRTLFLLGVTKYTAGPYECEIRNPVSASRSDPFTLNLLPKLPKPY 243

Query: 306 VQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLI 365
           +     +  E    L   C         + W  +G++L  +       PR++   +  ++
Sbjct: 244 ITINNLKPRENKDVLNFTCEPKSENYTYIWWL-NGQSLPVS-------PRVKRPIENRIL 295

Query: 366 VRP--VRSDHARYTCRVRSPFGH-REAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGS 422
           + P   R++   Y C +R  +G  R     ++V YGPD P I  S         +  +G 
Sbjct: 296 ILPSVTRNETGPYQCEIRDQYGGIRSYPVTLNVLYGPDLPRIYPSFT-------YYRSGE 348

Query: 423 NVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRR 482
            + L C+A S PPA  +W++    + +   G +L +P +   H+G YAC   N  TG+  
Sbjct: 349 VLYLSCSADSNPPAQYSWTINGKFQLS---GQKLFIPQITTKHSGLYACSVRNSATGKES 405

Query: 483 RSLLNLTVA 491
              + + V+
Sbjct: 406 SKSMTVKVS 414


>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
           sapiens]
          Length = 790

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 111/464 (23%), Positives = 172/464 (37%), Gaps = 64/464 (13%)

Query: 137 TVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVG 196
           T++ P   +   +      ++AP      D ++L  S+  P      +  S  S  Q  G
Sbjct: 330 TLEWPLQGVPISLVINSTGLKAPGRL---DSVELAQSSGKPLLTLPTKPLSNGSTHQLWG 386

Query: 197 GPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHL- 255
           GP          L +    + G P   V        ++  G+ PGAPL+S+ P    +L 
Sbjct: 387 GPPFHTPKERFYLKVKGKDHEGNPLLRV------SGVSYSGVAPGAPLVSMAPRIHGYLH 440

Query: 256 ---------------RFDQARGVLELASAQ-LDDAGVYTAEVIRAGVSQQ-THEFT---- 294
                          R    RG   L   +   ++G  + E++RA  +++ T+E T    
Sbjct: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 500

Query: 295 ---------VGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEA 345
                    + V +P PQL   P    +    A L  R LG  P    L+W RD R L A
Sbjct: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYN--LTWVRDWRVLPA 558

Query: 346 AESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTIT 405
           +    A+   +  E     I   + +D  RY C   +  G   A+  + V   P     T
Sbjct: 559 STGRVAQLADLSLE-----ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHT 613

Query: 406 VSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWS-----LADPAEAAVPAGSRLLLPA 460
            S        +  + G  V + C+A+  P   I+WS     L + +   V A   L++  
Sbjct: 614 SS--------QHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 665

Query: 461 VGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPP-GAPQCSVEGGPGDRSLRFRCSWPG 519
           V P  AG Y+C A N   G  + + + L   D P   A    V    G+ ++   C   G
Sbjct: 666 VAPEDAGNYSCQATN-EVGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEEAV-LVCEASG 722

Query: 520 GAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLA 563
             P   + ++G  E I A   SS     +PA         TC A
Sbjct: 723 VPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA 766



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 54/216 (25%), Positives = 92/216 (42%), Gaps = 22/216 (10%)

Query: 264 LELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLR 323
           LE++     D G Y  + + +  +  T      +    PQ+S+   +    +G  E+++ 
Sbjct: 571 LEISGIIPTDGGRY--QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV-EVKVS 627

Query: 324 CLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHA-RYTCRVRS 382
           C   G     +SWSR+ +AL+       E  R+  +    LI++ V  + A  Y+C+  +
Sbjct: 628 CSASGYPTPHISWSRESQALQ-------EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680

Query: 383 PFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSL 442
             G  +    V+++Y  DPP+++  +         V  G    L C A+  PP  + W  
Sbjct: 681 EVGTDQET--VTLYY-TDPPSVSAVN-----AVVLVAVGEEAVLVCEASGVPPPRVIWYR 732

Query: 443 ADPAEAAVPAGS---RLLLPAVGPGHAGTYACLAAN 475
                   P GS   +L +PA     AGTY C A N
Sbjct: 733 GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 90/332 (27%), Positives = 129/332 (38%), Gaps = 31/332 (9%)

Query: 350 GAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSD 409
           G E     S      I+R  +++   Y C   S  G   A A + V    DPP   V   
Sbjct: 467 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPPPQLVP-- 521

Query: 410 RDAAPARFVTAGSNVTLRCAAASRPPADITWSL------ADPAEAAVPAGSRLLLPAVGP 463
              AP   V+ G    L C      P ++TW        A     A  A   L +  + P
Sbjct: 522 ---APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIP 578

Query: 464 GHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCS---WPGG 520
              G Y C+A+N   G  R S+  L V + P  +   S +       ++  CS   +P  
Sbjct: 579 TDGGRYQCVASNAN-GVTRASVW-LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP 636

Query: 521 APAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVT---PE 577
             + S + Q L E  R    +   L      P  +G   +C A + V T   TVT    +
Sbjct: 637 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAG-NYSCQATNEVGTDQETVTLYYTD 695

Query: 578 APREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRP--LAPGGGS--RLRLSQD 633
            P    ++ +V      EA +  EASG PPP R  W R G    LAP G S  +LR+   
Sbjct: 696 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPP-RVIWYRGGLEMILAPEGSSSGKLRIPA- 753

Query: 634 GRKLHIGNFSLDW--DLGNYSVLCSGALGAGG 663
            ++   G ++     +LG+ S     A+G GG
Sbjct: 754 AQERDAGTYTCRAVNELGDASAEIQLAVGRGG 785



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 81/304 (26%), Positives = 122/304 (40%), Gaps = 39/304 (12%)

Query: 467 GTYACLAANPR-TGRRRRSLLNLTVADLPPG-APQCSVEGGPGDRSLRFRCSWPGGAPAA 524
           GTY C A +   TGR +  ++   V D PP   P  +V   PG+ ++   C   G AP  
Sbjct: 491 GTYECTAVSRAGTGRAKAQIV---VTDPPPQLVPAPNVTVSPGETAV-LSCRVLGEAPYN 546

Query: 525 SL---QFQGLPEGI-RAGPVSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTV---TPE 577
                 ++ LP    R   ++ + L      P   G    C+A +       +V     E
Sbjct: 547 LTWVRDWRVLPASTGRVAQLADLSLEISGIIPT-DGGRYQCVASNANGVTRASVWLLVRE 605

Query: 578 APREVLLHPLVAETRLG-EAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRK 636
           AP +V +H        G E +V+  ASG P P   SW+RE + L     SR+ +   G  
Sbjct: 606 AP-QVSIHTSSQHFSQGVEVKVSCSASGYPTP-HISWSRESQALQED--SRIHVDAQGTL 661

Query: 637 LHIGNFSLDWDLGNYSVLCSGALGAGGDQITLI---GPSISSWRLQRARDAAVLTWDVER 693
           +  G      D GNYS   +  +G   + +TL     PS+S      A +A VL    E 
Sbjct: 662 IIQG--VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS------AVNAVVLVAVGEE 713

Query: 694 GALISSFEIQAWPDGPALGRTSTYRDWVSLLILGPQERSAVVPLP---PRNPGTWTFRIL 750
             L+          G    R   YR  + +++      S  + +P    R+ GT+T R +
Sbjct: 714 AVLVCE------ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV 767

Query: 751 PILG 754
             LG
Sbjct: 768 NELG 771



 Score = 30.8 bits (68), Expect = 5.7
 Identities = 45/188 (23%), Positives = 65/188 (34%), Gaps = 30/188 (15%)

Query: 218 GPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVY 277
           G PT  + W R S+ L                  R H+    A+G L +     +DAG Y
Sbjct: 632 GYPTPHISWSRESQALQEDS--------------RIHV---DAQGTLIIQGVAPEDAGNY 674

Query: 278 TAEVIR-AGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSW 336
           + +     G  Q+T    V +Y   P       A        E  L C   G     + W
Sbjct: 675 SCQATNEVGTDQET----VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW 730

Query: 337 SRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVF 396
            R G  +  A  EG+ + ++R    Q         D   YTCR  +  G   A   ++V 
Sbjct: 731 YRGGLEMILAP-EGSSSGKLRIPAAQ-------ERDAGTYTCRAVNELGDASAEIQLAVG 782

Query: 397 YGPDPPTI 404
            G   P +
Sbjct: 783 RGGGYPWV 790


>gi|10835203 advanced glycosylation end product-specific receptor
           isoform 1 precursor [Homo sapiens]
          Length = 404

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 77/332 (23%), Positives = 122/332 (36%), Gaps = 39/332 (11%)

Query: 217 PGPPTSLVVWRRGS------KVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQ 270
           P  P   + W+  +      KVL+  G GP   +  + P            G L L +  
Sbjct: 42  PKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLP-----------NGSLFLPAVG 90

Query: 271 LDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP- 329
           + D G++  + +     +    + V VY+   +  +   A E   G       C+  G  
Sbjct: 91  IQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSY 150

Query: 330 GRGELSWSRDGRAL---EAAESEGAETPRMRSEG----DQLLIVRPVRSDHAR--YTCRV 380
             G LSW  DG+ L   E   S   +T R    G       L+V P R    R  ++C  
Sbjct: 151 PAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSF 210

Query: 381 RSPFGHREAAADVSV---FYGPDP---PTITVSSDRDAAPARFVTAGSNVTLRCAAASRP 434
                   A     +    + P P     + V  +  A     V  G  VTL C   ++P
Sbjct: 211 SPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGA-----VAPGGTVTLTCEVPAQP 265

Query: 435 PADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLP 494
              I W + D     +P    L+LP +GP   GTY+C+A +   G +    +++++ +  
Sbjct: 266 SPQIHW-MKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPG 324

Query: 495 PGAPQCSVEGGPGDRSLRFRCSWPGGAPAASL 526
              P     GG G  +L       GG   A+L
Sbjct: 325 EEGPTAGSVGGSGLGTLALALGILGGLGTAAL 356


>gi|4506175 pregnancy specific beta-1-glycoprotein 6 isoform a [Homo
           sapiens]
          Length = 435

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 42/155 (27%), Positives = 75/155 (48%), Gaps = 15/155 (9%)

Query: 353 TPRMRSEGDQLLIVRP--VRSDHARYTCRVRSPFGH-REAAADVSVFYGPDPPTITVSSD 409
           +PR++   +  +++ P   R++   Y C +R  +G  R     ++V YGPD P I  S  
Sbjct: 282 SPRVKRPIENRILILPSVTRNETGPYQCEIRDRYGGIRSNPVTLNVLYGPDLPRIYPSFT 341

Query: 410 RDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTY 469
                  +  +G N+ L C A S PPA+ +W++    + +   G +L +P +   H+G Y
Sbjct: 342 -------YYRSGENLDLSCFADSNPPAEYSWTINGKFQLS---GQKLFIPQITTNHSGLY 391

Query: 470 ACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEG 504
           AC   N  TG+     + + V++    +PQ +  G
Sbjct: 392 ACSVRNSATGKEISKSMIVKVSE--TASPQVTYAG 424



 Score = 33.9 bits (76), Expect = 0.67
 Identities = 58/234 (24%), Positives = 86/234 (36%), Gaps = 24/234 (10%)

Query: 272 DDAGVYTAEVIRA--GVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP 329
           +DAG YT  +I+   G    T  FTV +Y   P+ S+        E    +RL C    P
Sbjct: 114 EDAGSYTLHIIKRGDGTGGVTGYFTVTLYSETPKPSISSSNLNPREVMEAVRLICDPETP 173

Query: 330 GRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPF-GHRE 388
               L W  +G+ L           ++      L +    +     Y C +R+P    R 
Sbjct: 174 DASYL-WLLNGQNLPM-----THRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRS 227

Query: 389 AAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW----SLAD 444
               +++      P IT+ ++ +    + V A       C   SR    I W    SL  
Sbjct: 228 DPVTLNLLPKLPMPYITI-NNLNPREKKDVLA-----FTCEPKSRNYTYIWWLNGQSLPV 281

Query: 445 PAEAAVPAGSR-LLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV---ADLP 494
                 P  +R L+LP+V     G Y C     R G  R + + L V    DLP
Sbjct: 282 SPRVKRPIENRILILPSVTRNETGPYQC-EIRDRYGGIRSNPVTLNVLYGPDLP 334


>gi|47419900 pregnancy specific beta-1-glycoprotein 4 isoform 2
           [Homo sapiens]
          Length = 326

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 55/224 (24%), Positives = 91/224 (40%), Gaps = 19/224 (8%)

Query: 272 DDAGVYTAEVI--RAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP 329
           +DAG YT  +I  R G    T  FT  ++   P+ S+        E    + L C    P
Sbjct: 115 EDAGSYTLHIIKRRDGTGGVTGHFTFTLHLETPKPSISSSNLNPREAMEAVILTCDPATP 174

Query: 330 GRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFG-HRE 388
                 W  +G++L           ++      L I    +     Y C +R+P    R 
Sbjct: 175 A-ASYQWWMNGQSLPMTHRL-----QLSKTNRTLFIFGVTKYIAGPYECEIRNPVSASRS 228

Query: 389 AAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEA 448
               +++ +GPD P+I  S         +  +G N+ L C A S P A  +W++    + 
Sbjct: 229 DPVTLNLLHGPDLPSIYPSFT-------YYRSGENLYLSCFAESNPRAQYSWTINGKFQL 281

Query: 449 AVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVAD 492
           +   G +L +P +   H+G YAC   N  TG+     + + V+D
Sbjct: 282 S---GQKLSIPQITTKHSGLYACSVRNSATGKESSKSITVKVSD 322


>gi|157805480 pregnancy specific beta-1-glycoprotein 7 precursor
           [Homo sapiens]
          Length = 419

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 40/143 (27%), Positives = 69/143 (48%), Gaps = 13/143 (9%)

Query: 353 TPRMRSEGDQLLIVRP--VRSDHARYTCRVRSPFGH-REAAADVSVFYGPDPPTITVSSD 409
           +PR++   +  +++ P   R++   Y C +R  +G  R     ++V YGPD P I  S  
Sbjct: 283 SPRVKRRIENRILILPSVTRNETGPYQCEIRDRYGGIRSDPVTLNVLYGPDLPRIYPSFT 342

Query: 410 RDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTY 469
                  +  +G N+ L C A S PPA  +W++    + +   G +L +P +   H+G Y
Sbjct: 343 -------YYHSGQNLYLSCFADSNPPAQYSWTINGKFQLS---GQKLSIPQITTKHSGLY 392

Query: 470 ACLAANPRTGRRRRSLLNLTVAD 492
           AC   N  TG+     + + V+D
Sbjct: 393 ACSVRNSATGKESSKSVTVRVSD 415


>gi|73661174 pregnancy specific beta-1-glycoprotein 6 isoform b
           [Homo sapiens]
          Length = 424

 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 13/131 (9%)

Query: 353 TPRMRSEGDQLLIVRP--VRSDHARYTCRVRSPFGH-REAAADVSVFYGPDPPTITVSSD 409
           +PR++   +  +++ P   R++   Y C +R  +G  R     ++V YGPD P I  S  
Sbjct: 282 SPRVKRPIENRILILPSVTRNETGPYQCEIRDRYGGIRSNPVTLNVLYGPDLPRIYPSFT 341

Query: 410 RDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTY 469
                  +  +G N+ L C A S PPA+ +W++    + +   G +L +P +   H+G Y
Sbjct: 342 -------YYRSGENLDLSCFADSNPPAEYSWTINGKFQLS---GQKLFIPQITTNHSGLY 391

Query: 470 ACLAANPRTGR 480
           AC   N  TG+
Sbjct: 392 ACSVRNSATGK 402



 Score = 33.9 bits (76), Expect = 0.67
 Identities = 58/234 (24%), Positives = 86/234 (36%), Gaps = 24/234 (10%)

Query: 272 DDAGVYTAEVIRA--GVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGP 329
           +DAG YT  +I+   G    T  FTV +Y   P+ S+        E    +RL C    P
Sbjct: 114 EDAGSYTLHIIKRGDGTGGVTGYFTVTLYSETPKPSISSSNLNPREVMEAVRLICDPETP 173

Query: 330 GRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPF-GHRE 388
               L W  +G+ L           ++      L +    +     Y C +R+P    R 
Sbjct: 174 DASYL-WLLNGQNLPM-----THRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRS 227

Query: 389 AAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITW----SLAD 444
               +++      P IT+ ++ +    + V A       C   SR    I W    SL  
Sbjct: 228 DPVTLNLLPKLPMPYITI-NNLNPREKKDVLA-----FTCEPKSRNYTYIWWLNGQSLPV 281

Query: 445 PAEAAVPAGSR-LLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV---ADLP 494
                 P  +R L+LP+V     G Y C     R G  R + + L V    DLP
Sbjct: 282 SPRVKRPIENRILILPSVTRNETGPYQC-EIRDRYGGIRSNPVTLNVLYGPDLP 334


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,476,148
Number of Sequences: 37866
Number of extensions: 2265763
Number of successful extensions: 10637
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 386
Number of HSP's that attempted gapping in prelim test: 8402
Number of HSP's gapped (non-prelim): 1932
length of query: 867
length of database: 18,247,518
effective HSP length: 111
effective length of query: 756
effective length of database: 14,044,392
effective search space: 10617560352
effective search space used: 10617560352
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.