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Search of human proteins with 34304383
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34304383 Usher syndrome 1G protein [Homo sapiens]
(461 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34304383 Usher syndrome 1G protein [Homo sapiens] 928 0.0
gi|148664246 harmonin-interacting ankyrin-repeat containing prot... 335 4e-92
gi|110431370 espin [Homo sapiens] 77 3e-14
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 75 1e-13
gi|70995241 ankyrin repeat domain 10 [Homo sapiens] 71 2e-12
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 70 3e-12
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 70 3e-12
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 67 3e-11
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 67 3e-11
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 67 4e-11
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 67 4e-11
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 67 4e-11
gi|155969701 espin-like [Homo sapiens] 67 4e-11
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 66 6e-11
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 66 6e-11
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 66 6e-11
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 66 6e-11
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 66 6e-11
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 66 6e-11
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 66 6e-11
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 65 1e-10
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 65 1e-10
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 65 1e-10
gi|4506499 regulatory factor X-associated ankyrin-containing pro... 65 2e-10
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 64 2e-10
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 64 2e-10
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 64 4e-10
gi|16975496 cortactin binding protein 2 [Homo sapiens] 64 4e-10
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 63 5e-10
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 63 5e-10
>gi|34304383 Usher syndrome 1G protein [Homo sapiens]
Length = 461
Score = 928 bits (2398), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK
Sbjct: 1 MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
Query: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI
Sbjct: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
Query: 121 AAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSS 180
AAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSS
Sbjct: 121 AAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSS 180
Query: 181 LTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKS 240
LTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKS
Sbjct: 181 LTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKS 240
Query: 241 ARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTD 300
ARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTD
Sbjct: 241 ARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTD 300
Query: 301 SGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSLGSA 360
SGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSLGSA
Sbjct: 301 SGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSLGSA 360
Query: 361 NSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALML 420
NSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALML
Sbjct: 361 NSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALML 420
Query: 421 CSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL 461
CSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL
Sbjct: 421 CSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL 461
>gi|148664246 harmonin-interacting ankyrin-repeat containing protein
[Homo sapiens]
Length = 417
Score = 335 bits (860), Expect = 4e-92
Identities = 200/464 (43%), Positives = 269/464 (57%), Gaps = 50/464 (10%)
Query: 1 MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
M+ +YH+AA D YLELLKEAT+++LN DEDGMTPTL AAYHGNLE+L +I SRGGDPD+
Sbjct: 1 MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDR 60
Query: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
CDIWGNTPLH AASNGH HC+SFLV+FGANI+ LDND TPLD AA + ECV LD
Sbjct: 61 CDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKA 120
Query: 121 AAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSS 180
A Q+ +NPK V +LK++A + A R+I+EC +LQ +H +M Y +E S TLS S
Sbjct: 121 ATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKE---ESGTLSSSK 177
Query: 181 LTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKS 240
T S S S A+ GT +K G + TFK+ K
Sbjct: 178 GTFSRSSP-------------SNASAPGTFGSLSK----------GIKDTFKIKFKKNKD 214
Query: 241 ARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDE-DSVSRATLAAEPAHSEVST 299
G + S G+ + ++F +E DS S +E
Sbjct: 215 TAEQVGKEGRS----------------GQRNVMEVFREEEEDSFSGDFKEKLQLSAEEDG 258
Query: 300 DSGHDSLFTRPGLGTMVFRRNYLSS--GLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSL 357
H+S+ RPGLG++VFRRN +SS + RE G P LQ + + D
Sbjct: 259 SVHHESILNRPGLGSIVFRRNRISSPEDISDSKREFG----FKLPSELLQRQGASEADEG 314
Query: 358 GSANSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEA 417
+ ++ ++LPWD+ ++ +ED+ T PLE FL S H+E+F + ++E+IDLEA
Sbjct: 315 AADEEGEENGLKDDLPWDDDEVEWEEDVVDAT-PLEVFLLSQHLEEFLPIFKREQIDLEA 373
Query: 418 LMLCSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL 461
L+LCSD DL+SI + LGPRKK+L A+ RR+Q +++P L DT L
Sbjct: 374 LLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL 417
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 77.0 bits (188), Expect = 3e-14
Identities = 44/118 (37%), Positives = 62/118 (52%), Gaps = 4/118 (3%)
Query: 6 HRAARDGYLEL---LKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AA+ G+ + L T L+ D+DG T +AA G+ + L ++ GG+ D
Sbjct: 211 HAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS-AD 269
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
+WG TPLH AA NG L C LV GA + D D +T D++ GH C RYL ++
Sbjct: 270 LWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTV 327
Score = 53.1 bits (126), Expect = 5e-07
Identities = 43/120 (35%), Positives = 56/120 (46%), Gaps = 5/120 (4%)
Query: 3 DQYHRAARDGYLELLKEATRKELNAP---DEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
+Q +AAR G L++L+ L P D P AA G L LR +V P
Sbjct: 4 EQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPA 63
Query: 60 KCDIW-GNTPLHLAASNGHLHCLSFLVS-FGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TP H A++ GHL CL +L+S G + DN T L +AA GH E V +L
Sbjct: 64 AARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWL 123
Score = 52.0 bits (123), Expect = 1e-06
Identities = 41/117 (35%), Positives = 57/117 (48%), Gaps = 5/117 (4%)
Query: 6 HRAARDG---YLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSR-GGDPDKC 61
H AA G L LL E + +NA ++G TP A G+LE + +V G DP
Sbjct: 143 HYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHAR 202
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVS-FGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH AA GH + +LVS ++ D D T + AA +GH + + +L
Sbjct: 203 AHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWL 259
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/119 (33%), Positives = 55/119 (46%), Gaps = 5/119 (4%)
Query: 6 HRAARDGYLELLKEATRK---ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AAR G+ E++ + A + G P +AA G+ SLRL+V +
Sbjct: 109 HLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQ 168
Query: 63 IW-GNTPLHLAASNGHLHCLSFLVS-FGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
G TPL+LA GHL +LV GA+ +D TPL AA GH + +L S
Sbjct: 169 TKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVS 227
Score = 44.3 bits (103), Expect = 2e-04
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 5/117 (4%)
Query: 6 HRAARDGYLELLKEATRK---ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGG-DPDKC 61
H A+ G+L L+ + + D G T AA G+ E + ++ GG DP
Sbjct: 75 HDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAA 134
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVS-FGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G P+H AA+ G L LV + + + TPL +A +GH+E +YL
Sbjct: 135 TDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYL 191
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 75.1 bits (183), Expect = 1e-13
Identities = 38/117 (32%), Positives = 65/117 (55%), Gaps = 2/117 (1%)
Query: 8 AARDGYLELLKEATRKELNAPDED--GMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
A+++G++ +++E + +N D G T +WA Y G + + L++S G +P ++
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
P+ AA GH + L+ GA + C D TPL AA KGH+ECV++L ++ A
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGA 194
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/94 (30%), Positives = 51/94 (54%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++N D+ G TP +WAA G+LE ++ +++ G D D+ T L +A G+ +
Sbjct: 162 KVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKE 221
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
++ N+ D D +T L +A+ +GH E V+ L
Sbjct: 222 ILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Score = 50.4 bits (119), Expect = 3e-06
Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 23 KELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
K+++ +E G TP + AA GNLE ++ ++ G + + D+ T L A+ GH+H +
Sbjct: 29 KDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVE 88
Query: 83 FLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVG 133
L+ G N+ D T L A KG + V L S A NP + G
Sbjct: 89 ELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA-----NPSVTG 134
Score = 50.4 bits (119), Expect = 3e-06
Identities = 26/81 (32%), Positives = 44/81 (54%)
Query: 35 PTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCL 94
P +WAA G+ + + L++ G + D +G TPL AA GHL C+ L++ GA++
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 95 DNDYHTPLDMAAMKGHMECVR 115
+ T L +A G+ + V+
Sbjct: 200 GANSMTALIVAVKGGYTQSVK 220
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/112 (31%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 8 AARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AAR G+LE +K A +++ + MT + A G +S++ I+ R + + D G
Sbjct: 177 AARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG 236
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
NT L +A+ GH + L+ G + D T L A GH+E VR L
Sbjct: 237 NTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRAL 288
Score = 46.6 bits (109), Expect = 5e-05
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
A R G++E+++ +K +++ +D T WA GN +R I+ D + C G
Sbjct: 276 AVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDG 335
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMA 105
TPL A ++ + L+ GA + +D TPL +A
Sbjct: 336 ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
Score = 43.1 bits (100), Expect = 5e-04
Identities = 25/74 (33%), Positives = 40/74 (54%)
Query: 44 NLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLD 103
N+ +L+ ++ + D D+ + G TPL +AA G+L + L+ GAN D D T L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 104 MAAMKGHMECVRYL 117
A+ +GH+ V L
Sbjct: 77 SASKEGHVHIVEEL 90
Score = 41.6 bits (96), Expect = 0.002
Identities = 32/110 (29%), Positives = 53/110 (48%), Gaps = 2/110 (1%)
Query: 8 AARDGYLELLKEATRKE--LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
A + GY + +KE ++ +N D+DG T + A+ G+ E ++ ++ G + D G
Sbjct: 210 AVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSG 269
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVR 115
+T L A GH+ + L+ A+I D T L A KG+ VR
Sbjct: 270 DTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319
>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
Length = 420
Score = 70.9 bits (172), Expect = 2e-12
Identities = 46/118 (38%), Positives = 60/118 (50%), Gaps = 6/118 (5%)
Query: 6 HRAARDGYL----ELLKEATRKELNAPDED-GMTPTLWAAYHGNLESLRLIVSRGGDPD- 59
HRA RDG L LL++ L + D G TP WAA+ G LE L +V G +
Sbjct: 27 HRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ TP H+AA GH CL +L+ GANI D + TP+ AA G +EC+ L
Sbjct: 87 STTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
Score = 38.9 bits (89), Expect = 0.010
Identities = 21/62 (33%), Positives = 32/62 (51%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+N PD +G TP AA G+LE + +V+ G D + G T +A + G C FL
Sbjct: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
Query: 85 VS 86
++
Sbjct: 178 LN 179
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 70.5 bits (171), Expect = 3e-12
Identities = 37/95 (38%), Positives = 57/95 (60%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
L A D+ G TP AA HG+ +L++++ G DP D P+H AA +G L CL L
Sbjct: 91 LTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLL 150
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
V +G +I +D + + P+ +AAM+GH+ C ++L S
Sbjct: 151 VKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVS 185
Score = 49.7 bits (117), Expect = 6e-06
Identities = 33/121 (27%), Positives = 60/121 (49%), Gaps = 4/121 (3%)
Query: 3 DQYHRAARDGYLELLKEATRKELNAPDEDGMT-PTLWAAYHGNLESLRLIVSRG--GDPD 59
D R + L+ ++ A + + D++ + P AA+ G+L L+ +V G +
Sbjct: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
+ D G+TP+H AA GH+ CL +L+ GA+ + P D+A H+ V+ L+
Sbjct: 266 RADN-GSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
Query: 120 I 120
+
Sbjct: 325 L 325
Score = 37.0 bits (84), Expect = 0.038
Identities = 22/63 (34%), Positives = 30/63 (47%)
Query: 48 LRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAM 107
L ++ G D G T H+AA G C+ L+ GAN+ D+ TPL +AA
Sbjct: 48 LHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAAT 107
Query: 108 KGH 110
GH
Sbjct: 108 HGH 110
Score = 35.4 bits (80), Expect = 0.11
Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Query: 68 PLHLAASNGHLHCLSFLVSFGA-NIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSS 126
P H+AA G L L LV G NI ++ TP+ AA +GH+EC+++L + A +
Sbjct: 239 PGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
Query: 127 LN 128
N
Sbjct: 299 TN 300
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 70.5 bits (171), Expect = 3e-12
Identities = 38/94 (40%), Positives = 60/94 (63%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
E++ D+DGMTP L AAY G+++ + L++ G D D D G TPL AAS GH ++
Sbjct: 740 EVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNT 799
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L+ +GA + +D++ T L +A+ +G++E VR L
Sbjct: 800 LLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Score = 67.0 bits (162), Expect = 3e-11
Identities = 41/93 (44%), Positives = 52/93 (55%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+N D +G T AAY G+L+ + L+VSRG D + D G+TPL LAA GH ++ L
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ GANI D D T L AA GH E V L
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSAL 630
Score = 62.4 bits (150), Expect = 8e-10
Identities = 34/89 (38%), Positives = 49/89 (55%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFG 88
D +G T A+ GN+E +R ++ RG D + D G TPLH+AA GH L+ G
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 89 ANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
A +DND P +A+ +GH +CV+ L
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 58.5 bits (140), Expect = 1e-08
Identities = 37/99 (37%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 24 ELNAPDEDGMTPTLWAAY-----HGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHL 78
E+N D DG T AA G+ + L++ RG + D CD G TPL +AA GH+
Sbjct: 702 EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761
Query: 79 HCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ L+ GA++ DN+ TPL AA GH V L
Sbjct: 762 DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Score = 53.9 bits (128), Expect = 3e-07
Identities = 38/148 (25%), Positives = 73/148 (49%), Gaps = 7/148 (4%)
Query: 6 HRAARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H + G++E+++ A ++NA D + + AA+ G+++ ++L++ G D
Sbjct: 984 HVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G T L +AA GH+ + L+ GA+ D T + +AA GH + ++ L+ A
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA- 1102
Query: 124 QSSLN---PKLVGKLKDKAFREAERRIR 148
SSLN P V ++ K + +++
Sbjct: 1103 -SSLNGCSPSPVHTMEQKPLQSLSSKVQ 1129
Score = 52.0 bits (123), Expect = 1e-06
Identities = 33/103 (32%), Positives = 52/103 (50%)
Query: 15 ELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAAS 74
E+L+ + + ED T + +S+R ++ G ++CD G T L AA
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAY 554
Query: 75 NGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+G L ++ LVS GA++ D HTPL +AA +GH + V L
Sbjct: 555 SGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Score = 51.6 bits (122), Expect = 1e-06
Identities = 28/95 (29%), Positives = 49/95 (51%), Gaps = 2/95 (2%)
Query: 24 ELNAPDEDGMTPTLWA-AYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
++N D DG PTL+ A L + G + + D G T LH++ GH+ +
Sbjct: 938 DVNCKDADGR-PTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996
Query: 83 FLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L+++ A++ DN+ + L AA +GH++ V+ L
Sbjct: 997 VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 1031
Score = 50.8 bits (120), Expect = 3e-06
Identities = 34/117 (29%), Positives = 56/117 (47%), Gaps = 2/117 (1%)
Query: 8 AARDGYLELLKEATRKEL--NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
A+ G +E+++ + L N D+ G TP AA+ G+ ++ +G ++ D G
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
P LA+ GH C+ L+ +NI D L +AA++GH + V L S A
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 2/112 (1%)
Query: 8 AARDGYLELLK--EATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AAR G+ +++ +N D+DG T AA+ G+ E + ++ G D D
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
T L AA GH + L+ GA + DN+ T L AA GH E V +L
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Score = 48.5 bits (114), Expect = 1e-05
Identities = 34/109 (31%), Positives = 50/109 (45%), Gaps = 2/109 (1%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA G L+++ + +L D G TP AA G+ + + ++ G + + D G
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECV 114
T L AA GH +S L+ G + C D D T L AA GH + V
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 4/114 (3%)
Query: 6 HRAARDGYLELLKEATRKE---LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AA +G+ L+ EA ++ N D DG P + A+ G+ + +++++ + D+
Sbjct: 852 HMAAFEGH-RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRG 910
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRY 116
G L +AA GH + L S GA++ C D D L + A++ + Y
Sbjct: 911 YDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/136 (23%), Positives = 63/136 (46%), Gaps = 2/136 (1%)
Query: 8 AARDGYLELLKEATRKELNAPDE--DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
A+++G+ + ++ + N DG AA G+ + + L+ S G D + D G
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADG 946
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQS 125
L++ A L + + GAN+ D + T L ++ +GHME V+ L + A +
Sbjct: 947 RPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
Query: 126 SLNPKLVGKLKDKAFR 141
+ + + L+ A++
Sbjct: 1007 AADNEKRSALQSAAWQ 1022
Score = 43.9 bits (102), Expect = 3e-04
Identities = 25/93 (26%), Positives = 48/93 (51%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+ A D +G T + + G++E ++++++ D + D + L AA GH+ + L
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 1031
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ GA + N T L +AA +GH++ V+ L
Sbjct: 1032 IEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Score = 42.0 bits (97), Expect = 0.001
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 5/99 (5%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
+++ D D T AA+ G+ + + ++ G + +K D G T L AA GH +
Sbjct: 636 KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695
Query: 84 LVSFGANIWCLDNDYHTPLDMAAM-----KGHMECVRYL 117
L+ GA + D D T L +AA+ KGH V L
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 67.0 bits (162), Expect = 3e-11
Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 4/116 (3%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H+A+ E++K RK N D+ G+TP AA +G LESL +++S G + + +
Sbjct: 78 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQAL 137
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGA--NIWCLDNDYHTPLDMAAMKGHMECVRYL 117
TPL +AA GH C+ L+S GA +++C ++ + P+ AA GH + + L
Sbjct: 138 DKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 193
Score = 64.7 bits (156), Expect = 2e-10
Identities = 35/84 (41%), Positives = 51/84 (60%)
Query: 39 AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY 98
A++ N E ++L++ +G + + D +G TPL +AA G L LS L+S GAN+ C D
Sbjct: 80 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDK 139
Query: 99 HTPLDMAAMKGHMECVRYLDSIAA 122
TPL +AA +GH +CV L S A
Sbjct: 140 ATPLFIAAQEGHTKCVELLLSSGA 163
Score = 45.8 bits (107), Expect = 8e-05
Identities = 35/115 (30%), Positives = 51/115 (44%), Gaps = 6/115 (5%)
Query: 8 AARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC---D 62
AA+ G LE L ++ +N D TP AA G+ + + L++S G DPD D
Sbjct: 113 AAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNED 172
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
W P+H AA GH L L+ + +P+ A GH +C+ L
Sbjct: 173 SW-QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 226
Score = 44.3 bits (103), Expect = 2e-04
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 5/121 (4%)
Query: 6 HRAARDGY---LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC- 61
H AA G+ +++L EA + NA + TP A +G ++ LRL++ G + +
Sbjct: 11 HLAASQGHWKIVQILLEAGA-DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIA 121
+ G LH A+ + + L+ GAN C D+ TPL +AA G +E + L S
Sbjct: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
Query: 122 A 122
A
Sbjct: 130 A 130
Score = 33.1 bits (74), Expect = 0.54
Identities = 19/53 (35%), Positives = 27/53 (50%)
Query: 65 GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G LHLAAS GH + L+ GA+ + TPL +A G ++ +R L
Sbjct: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 58
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 67.0 bits (162), Expect = 3e-11
Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 4/116 (3%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H+A+ E++K RK N D+ G+TP AA +G LESL +++S G + + +
Sbjct: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQAL 210
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGA--NIWCLDNDYHTPLDMAAMKGHMECVRYL 117
TPL +AA GH C+ L+S GA +++C ++ + P+ AA GH + + L
Sbjct: 211 DKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266
Score = 64.7 bits (156), Expect = 2e-10
Identities = 35/84 (41%), Positives = 51/84 (60%)
Query: 39 AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY 98
A++ N E ++L++ +G + + D +G TPL +AA G L LS L+S GAN+ C D
Sbjct: 153 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDK 212
Query: 99 HTPLDMAAMKGHMECVRYLDSIAA 122
TPL +AA +GH +CV L S A
Sbjct: 213 ATPLFIAAQEGHTKCVELLLSSGA 236
Score = 52.4 bits (124), Expect = 9e-07
Identities = 34/115 (29%), Positives = 60/115 (52%), Gaps = 5/115 (4%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIW- 64
AAR+G +++L++ +K ++ D G P AAYH ++E L+++++ + +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
Query: 65 --GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G LHLAAS GH + L+ GA+ + TPL +A G ++ +R L
Sbjct: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Score = 45.8 bits (107), Expect = 8e-05
Identities = 35/115 (30%), Positives = 51/115 (44%), Gaps = 6/115 (5%)
Query: 8 AARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC---D 62
AA+ G LE L ++ +N D TP AA G+ + + L++S G DPD D
Sbjct: 186 AAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNED 245
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
W P+H AA GH L L+ + +P+ A GH +C+ L
Sbjct: 246 SW-QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Score = 44.3 bits (103), Expect = 2e-04
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 5/121 (4%)
Query: 6 HRAARDGY---LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC- 61
H AA G+ +++L EA + NA + TP A +G ++ LRL++ G + +
Sbjct: 84 HLAASQGHWKIVQILLEAGA-DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 142
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIA 121
+ G LH A+ + + L+ GAN C D+ TPL +AA G +E + L S
Sbjct: 143 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 202
Query: 122 A 122
A
Sbjct: 203 A 203
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 66.6 bits (161), Expect = 4e-11
Identities = 45/138 (32%), Positives = 70/138 (50%), Gaps = 8/138 (5%)
Query: 6 HRAARDGYLE---LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AA+ G LE LL + ++NA D G TP +WAA H ++E +R++++RG D D
Sbjct: 722 HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTD 781
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
N LH A+ G L++ ++ ++ TPL +AA + + +CV S A
Sbjct: 782 NEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 841
Query: 123 KQSSLNPKLVGKLKDKAF 140
NP+L K D A+
Sbjct: 842 -----NPELRNKEGDTAW 854
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGG-DPDKCDIWGNTPLHLAASNGHLHCLSFLVSF 87
+EDG T AA GNLE + L++S G D + D G TP+ AA + H+ + L++
Sbjct: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 88 GANIWCLDNDYHTPLDMAAMKG 109
GA++ DN+ + L A+ G
Sbjct: 774 GADVTLTDNEENICLHWASFTG 795
Score = 43.9 bits (102), Expect = 3e-04
Identities = 21/51 (41%), Positives = 27/51 (52%)
Query: 67 TPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
TPLH AA G + L+ GANI +D TPL A + H+E RY+
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYM 703
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 4/118 (3%)
Query: 4 QYHRAARDGYLE----LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
Q + + + G L+ +L + + + TP AA G++E +++ G + +
Sbjct: 619 QLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
D TPL A N HL ++V G ++ + D T L AA G++E V L
Sbjct: 679 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 66.6 bits (161), Expect = 4e-11
Identities = 45/138 (32%), Positives = 70/138 (50%), Gaps = 8/138 (5%)
Query: 6 HRAARDGYLE---LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AA+ G LE LL + ++NA D G TP +WAA H ++E +R++++RG D D
Sbjct: 756 HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTD 815
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
N LH A+ G L++ ++ ++ TPL +AA + + +CV S A
Sbjct: 816 NEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 875
Query: 123 KQSSLNPKLVGKLKDKAF 140
NP+L K D A+
Sbjct: 876 -----NPELRNKEGDTAW 888
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGG-DPDKCDIWGNTPLHLAASNGHLHCLSFLVSF 87
+EDG T AA GNLE + L++S G D + D G TP+ AA + H+ + L++
Sbjct: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 88 GANIWCLDNDYHTPLDMAAMKG 109
GA++ DN+ + L A+ G
Sbjct: 808 GADVTLTDNEENICLHWASFTG 829
Score = 43.9 bits (102), Expect = 3e-04
Identities = 21/51 (41%), Positives = 27/51 (52%)
Query: 67 TPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
TPLH AA G + L+ GANI +D TPL A + H+E RY+
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYM 737
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 4/118 (3%)
Query: 4 QYHRAARDGYLE----LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
Q + + + G L+ +L + + + TP AA G++E +++ G + +
Sbjct: 653 QLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
D TPL A N HL ++V G ++ + D T L AA G++E V L
Sbjct: 713 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 66.6 bits (161), Expect = 4e-11
Identities = 43/120 (35%), Positives = 68/120 (56%), Gaps = 7/120 (5%)
Query: 14 LELLKEATRKELNAPDEDGMT--PTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHL 71
L++L E + ++ + ++ T P AAYHG+ ++L ++V D D + G TPL L
Sbjct: 530 LDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDL 589
Query: 72 AASNGHLHCLSFLVSFGANIWCLDNDY---HTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
AA GH+ C+ L++ GA+I L DY TP+ AA GH EC+R L A Q++++
Sbjct: 590 AAFKGHVECVDVLINQGASI--LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 647
Score = 66.2 bits (160), Expect = 6e-11
Identities = 43/115 (37%), Positives = 63/115 (54%), Gaps = 3/115 (2%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G+ + ++ +++ PD+ G T AA GNLE L L+++ G D +K D
Sbjct: 377 HLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDK 436
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKG-HMECVRYL 117
+G +PLH AA+N + CL LV GA++ LD TPL AA +C+ YL
Sbjct: 437 FGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
Score = 63.5 bits (153), Expect = 4e-10
Identities = 35/104 (33%), Positives = 53/104 (50%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+N D G T AA+ G+ E ++L++SRG + + D +H AA GH+ + L
Sbjct: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
VS GA + C D +TPL AA G + V+YL + + N
Sbjct: 193 VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN 236
Score = 62.4 bits (150), Expect = 8e-10
Identities = 37/129 (28%), Positives = 64/129 (49%), Gaps = 6/129 (4%)
Query: 6 HRAARDGYLELLK-----EATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
H AA +G+ E L+ + ++ D +G TP + + +G+ + + ++++G + D
Sbjct: 622 HAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA 681
Query: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
D WG T LH A GH C+ L+ GA D+ TP+ ++A GH+ + L
Sbjct: 682 KDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQS 741
Query: 121 AAKQSSLNP 129
AA + NP
Sbjct: 742 AASMDA-NP 749
Score = 56.2 bits (134), Expect = 6e-08
Identities = 33/94 (35%), Positives = 47/94 (50%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++N +DG TP A HG + I+ G D D GNTPLH+AA GH ++
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 357
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L++ GA+ PL +AA+ G +C R L
Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
Score = 55.5 bits (132), Expect = 1e-07
Identities = 36/93 (38%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 34 TPTLWAAYHGNLESLRLIVSRGGDPDKCDIW---GNTPLHLAASNGHLHCLSFLVSFGAN 90
TP AA +G+ E LRL++ + DI G TPL L+ NGH C+ L++ GAN
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
Query: 91 IWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
+ D T L A+ GH ECV L AK
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711
Score = 54.7 bits (130), Expect = 2e-07
Identities = 41/131 (31%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 2 NDQYHRAARDGYLELLKEATRKELNAPDED--GMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N H AAR G+ L+ + GM P AA G + R ++S G D D
Sbjct: 340 NTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDID 399
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
D +G T LH AA+ G+L CL+ L++ GA+ D +PL AA + +C+ L
Sbjct: 400 TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVG 459
Query: 120 IAAKQSSLNPK 130
A + L+ +
Sbjct: 460 SGASVNDLDER 470
Score = 53.5 bits (127), Expect = 4e-07
Identities = 33/93 (35%), Positives = 50/93 (53%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
++ D++G TP AA +G+ + +++ G D K I G PLHLAA +G C L
Sbjct: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+S G +I D+ T L AA G++EC+ L
Sbjct: 392 LSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
Score = 52.4 bits (124), Expect = 9e-07
Identities = 34/88 (38%), Positives = 46/88 (52%), Gaps = 3/88 (3%)
Query: 25 LNAPDEDGMTPTLWAAY--HGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
+N +E G TP +AA HG L L L+V G D + G TPLH+ A +G
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
Query: 83 FLVSFGANIWCLDNDYHTPLDMAAMKGH 110
++ GA I C D + +TPL +AA GH
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Score = 50.8 bits (120), Expect = 3e-06
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 2/127 (1%)
Query: 6 HRAARDGYLELLKEA--TRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G E+++ + +NA D +TP A + E++++++ D + D
Sbjct: 46 HAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDK 105
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
TPLH+AA+N + C LV +N+ D T L AA GH E V+ L S A
Sbjct: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
Query: 124 QSSLNPK 130
++ + K
Sbjct: 166 INAFDKK 172
Score = 50.4 bits (119), Expect = 3e-06
Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 3/117 (2%)
Query: 6 HRAARDGYLELLKEA--TRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G LE L T + N D+ G +P +AA + N + L +V G + D
Sbjct: 410 HAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
Query: 64 WGNTPLHLAA-SNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
G TPLH AA S+ CL +L+ AN D + + +A GH C++ + S
Sbjct: 470 RGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIAS 526
Score = 50.1 bits (118), Expect = 4e-06
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 2/107 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G++E++K E+ D+ TP AA G + ++ ++ G D ++ +
Sbjct: 178 HWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNA 237
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGH 110
+GNTPLH+A NG ++ L+ GA + + TPL AA H
Sbjct: 238 YGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTH 284
Score = 49.7 bits (117), Expect = 6e-06
Identities = 37/115 (32%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 16 LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASN 75
LLK + ++NA D++ TP AA + ++ +V + + D G T LH AA +
Sbjct: 93 LLKHSA--DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFS 150
Query: 76 GHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPK 130
GH + L+S GANI D + AA GH+E V+ L S A+ + + K
Sbjct: 151 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 7/127 (5%)
Query: 6 HRAARDGY---LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDP--DK 60
H A +G+ +ELL E ++ + + +P A + N + +++ G +
Sbjct: 761 HWACYNGHETCVELLLE--QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNA 818
Query: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
D G TPLH AA H+ CL L+S A + +D+ TPL MAA G V L S
Sbjct: 819 TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
Query: 121 AAKQSSL 127
A+ + +L
Sbjct: 879 ASAELTL 885
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/101 (34%), Positives = 50/101 (49%), Gaps = 12/101 (11%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSR----------GGD--PDKCDIWGNTPLHLAASNG 76
D+ G ++A +G+ L+LI S G D D + +PLHLAA +G
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561
Query: 77 HLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
H L LV ++ ++ TPLD+AA KGH+ECV L
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
Score = 47.4 bits (111), Expect = 3e-05
Identities = 27/96 (28%), Positives = 48/96 (50%)
Query: 22 RKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCL 81
++++N D + TP AAY G+ E + L++ G + D TPLH A ++ +
Sbjct: 31 KEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAV 90
Query: 82 SFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L+ A++ D ++ TPL +AA ++C L
Sbjct: 91 QVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 9/131 (6%)
Query: 6 HRAARDGYL----ELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
H +A G++ LL+ A + N D G T WA Y+G+ + L++ +
Sbjct: 724 HLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF-Q 782
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLV-SFGANIW-CLDNDYHTPLDMAAMKGHMECVRYL 117
K + +PLH A N + L+ + GA+I D+ TPL AA H+EC++ L
Sbjct: 783 KTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842
Query: 118 DSIAAKQSSLN 128
S A+ +S++
Sbjct: 843 LSHNAQVNSVD 853
Score = 38.1 bits (87), Expect = 0.017
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 4/120 (3%)
Query: 14 LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG---NTPLH 70
+E+L + EL D T A G+ S LI+ + D + + TPLH
Sbjct: 872 VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH 931
Query: 71 LAASNGHLHCLSFLVSFGANIWCLDNDYHTP-LDMAAMKGHMECVRYLDSIAAKQSSLNP 129
+AA NG + L+ GA++ +D + +TP L A K +C+ + + SS +P
Sbjct: 932 VAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSP 991
Score = 37.7 bits (86), Expect = 0.022
Identities = 23/79 (29%), Positives = 38/79 (48%)
Query: 39 AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY 98
A ++G+ + +R ++ + D + D TPLH AA G + L+ GA + D+ +
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 99 HTPLDMAAMKGHMECVRYL 117
TPL A E V+ L
Sbjct: 75 LTPLHRAVASCSEEAVQVL 93
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 66.6 bits (161), Expect = 4e-11
Identities = 46/120 (38%), Positives = 59/120 (49%), Gaps = 6/120 (5%)
Query: 6 HRAARDGYLEL---LKEATRKELNAPDEDGMTPTLWAAYHGNLESL-RLIVSRGGDPDKC 61
H AA G+ L L T L A D +G T +AA G+ L RL++ G P
Sbjct: 210 HAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLM--GTPILR 267
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIA 121
D WG TPLH AA NG + C LVS + D D +T D+A GH +C +YL +A
Sbjct: 268 DSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVA 327
Score = 50.1 bits (118), Expect = 4e-06
Identities = 42/127 (33%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Query: 6 HRAARDGYLELLKEATRKEL---NAPDEDGMTPTLWAAYHGNLESLRLIVSRGG-DPDKC 61
H A R G+L+ +K ++ N +G TP AA G+L L +V GG
Sbjct: 41 HHATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQ 100
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIA 121
D G +PLHLAA GH + +L+ G + + PL AA+ G + C++ L A
Sbjct: 101 DASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLL--TA 158
Query: 122 AKQSSLN 128
A SS+N
Sbjct: 159 AHGSSVN 165
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 4/116 (3%)
Query: 6 HRAARDGYLELLKEATRKELNAPDE--DGMTPTLWAAYHGNLESLRLIVS-RGGDPDKCD 62
H AAR G+ L++ + +A E +G P AA G+L L+L+ + G ++
Sbjct: 109 HLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRT 168
Query: 63 IWGNTPLHLAASNGHLHCLSFLV-SFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G +PL+LA GHLH FLV GA++ D + L AA +GH V +L
Sbjct: 169 RSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWL 224
Score = 42.7 bits (99), Expect = 7e-04
Identities = 35/110 (31%), Positives = 49/110 (44%), Gaps = 5/110 (4%)
Query: 6 HRAARDG---YLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSR-GGDPDKC 61
H AA G L+LL A +N G +P A G+L + +V G D
Sbjct: 142 HHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLR 201
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSF-GANIWCLDNDYHTPLDMAAMKGH 110
+ G + LH AA+ GH + +LV+F + DN+ T L AA GH
Sbjct: 202 ALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGH 251
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 66.2 bits (160), Expect = 6e-11
Identities = 42/127 (33%), Positives = 67/127 (52%), Gaps = 2/127 (1%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N + RAAR G L+ + E + ++N +++G+ AA G++ ++ ++ RG D
Sbjct: 11 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
GNT LH+A+ G + LV GANI + TPL MAA + H++ V+YL
Sbjct: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130
Query: 120 IAAKQSS 126
A QS+
Sbjct: 131 NGANQST 137
Score = 60.8 bits (146), Expect = 2e-09
Identities = 33/87 (37%), Positives = 49/87 (56%)
Query: 31 DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGAN 90
+G+TP A+ GN ++L++ RGG D G TPLH AA +GH + L+ GA
Sbjct: 244 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
Query: 91 IWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ + +PL MAA H+ECV++L
Sbjct: 304 LLARTKNGLSPLHMAAQGDHVECVKHL 330
Score = 57.8 bits (138), Expect = 2e-08
Identities = 35/114 (30%), Positives = 59/114 (51%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPD--EDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ G L++ K ++ A ++G+TP AA++ N + L++ +G P
Sbjct: 547 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 606
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+AA + S L+++GA + TPL +A+ +GH + V L
Sbjct: 607 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 56.2 bits (134), Expect = 6e-08
Identities = 33/93 (35%), Positives = 47/93 (50%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+N E G TP AA++GN+ L+++RG D G TPLH+A+ G+ + + L
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ G I D TPL AA GH + V L
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/93 (34%), Positives = 49/93 (52%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+ A E G+TP AA+ G+L + L++ G PD +I G T LH+AA G + + L
Sbjct: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ GA + + TPL +A+ G E V+ L
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/114 (28%), Positives = 60/114 (52%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++G++ L++E + +++ + G T A+ G E ++++V G + +
Sbjct: 48 HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 107
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPL++AA H+ + +L+ GAN D TPL +A +GH + V L
Sbjct: 108 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Score = 54.7 bits (130), Expect = 2e-07
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPDE--DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ ++E +K + + D D +T AA+ G+ +L++ + +P+ +
Sbjct: 316 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 375
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+A + + LV +GA+I + TP+ +AA GH+ V L
Sbjct: 376 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A++ G ++K + +++A DG+TP AA G+ + + L++ RG
Sbjct: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G +PLH+AA H+ C+ L+ A + + DY T L +AA GH + L
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Query: 6 HRAARDGYLELLKEATRKELNA--PDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A+++G+ +++ K N + G+T AA + ++ G D D
Sbjct: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 705
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPL +A G++ ++FL+ GAN+ + +TPL AA +GH + L AK
Sbjct: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
Query: 124 QSS 126
++
Sbjct: 766 PNA 768
Score = 50.1 bits (118), Expect = 4e-06
Identities = 33/133 (24%), Positives = 65/133 (48%), Gaps = 2/133 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++ + + T+ + +A + G TP + A ++GN++ + ++ +G + +
Sbjct: 679 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 738
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPLH AA GH H ++ L+ GA + +T L +A G++ V L + +
Sbjct: 739 NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEE 798
Query: 124 QSSLNPKLVGKLK 136
++ + K K
Sbjct: 799 VTTTTTTITEKHK 811
Score = 48.9 bits (115), Expect = 1e-05
Identities = 34/114 (29%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKE--LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AAR G +E+++ R ++A + TP A+ G E ++L++ PD
Sbjct: 448 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH++A G + S L+ GA TPL +AA G ++ + L
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/114 (32%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G+ + K K N A +G TP A ++ + L+V G
Sbjct: 349 HVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 408
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TP+H+AA GHL+ + L+ GA+ + T L MAA G +E VR L
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Score = 46.2 bits (108), Expect = 6e-05
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 6 HRAARDGYLEL---LKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H +AR+G +++ L EA A + G TP AA +G+L+ +L++ R D
Sbjct: 514 HISAREGQVDVASVLLEAGAAHSLATKK-GFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 572
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
G TPLH+AA + L+ GA+ + +TPL +AA K M+ L + A
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632
Query: 123 K 123
+
Sbjct: 633 E 633
Score = 42.7 bits (99), Expect = 7e-04
Identities = 28/101 (27%), Positives = 46/101 (45%)
Query: 26 NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLV 85
+A ++G TP AA ++ +++ G + + G TPLHLA+ GH ++ L+
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 86 SFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSS 126
GANI T L +AA + + L A Q +
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Score = 42.4 bits (98), Expect = 9e-04
Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 6 HRAARDGYLELLKEATRKEL-------------NAPDEDGMTPTLWAAYHGNLESLRLIV 52
H A++GY L A + ++ N + G+TP A+ G+ + + L++
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 53 SRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYH-----TPLDMAAM 107
+G + G T LHLAA ++ L GA D D H TPL +A
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-----DQDAHTKLGYTPLIVACH 716
Query: 108 KGHMECVRYL 117
G+++ V +L
Sbjct: 717 YGNVKMVNFL 726
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/86 (25%), Positives = 42/86 (48%), Gaps = 2/86 (2%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N H A+ G E++K ++ +NA ++G TP AA +++ ++ ++ G +
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLV 85
G TPL +A GH ++ L+
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILL 162
Score = 38.1 bits (87), Expect = 0.017
Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 9/132 (6%)
Query: 6 HRAARDGY---LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AAR G+ +ELL E L A ++G++P AA ++E ++ ++ D
Sbjct: 283 HCAARSGHDQVVELLLERGAPLL-ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 341
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHME----CVRYLD 118
+ T LH+AA GH L+ AN + TPL +A K ++ V+Y
Sbjct: 342 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 401
Query: 119 SI-AAKQSSLNP 129
SI A +S L P
Sbjct: 402 SIQAITESGLTP 413
Score = 32.7 bits (73), Expect = 0.71
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 4/104 (3%)
Query: 6 HRAARDGYLELLKEATRKELNAPDE---DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H A+R G E++ + + + PD +G TP +A G ++ +++ G
Sbjct: 481 HIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 539
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAA 106
G TPLH+AA G L L+ A + TPL +AA
Sbjct: 540 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 66.2 bits (160), Expect = 6e-11
Identities = 42/127 (33%), Positives = 67/127 (52%), Gaps = 2/127 (1%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N + RAAR G L+ + E + ++N +++G+ AA G++ ++ ++ RG D
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
GNT LH+A+ G + LV GANI + TPL MAA + H++ V+YL
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 120 IAAKQSS 126
A QS+
Sbjct: 152 NGANQST 158
Score = 60.8 bits (146), Expect = 2e-09
Identities = 33/87 (37%), Positives = 49/87 (56%)
Query: 31 DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGAN 90
+G+TP A+ GN ++L++ RGG D G TPLH AA +GH + L+ GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 91 IWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ + +PL MAA H+ECV++L
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 57.8 bits (138), Expect = 2e-08
Identities = 35/114 (30%), Positives = 59/114 (51%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPD--EDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ G L++ K ++ A ++G+TP AA++ N + L++ +G P
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+AA + S L+++GA + TPL +A+ +GH + V L
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 56.2 bits (134), Expect = 6e-08
Identities = 33/93 (35%), Positives = 47/93 (50%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+N E G TP AA++GN+ L+++RG D G TPLH+A+ G+ + + L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ G I D TPL AA GH + V L
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/93 (34%), Positives = 49/93 (52%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+ A E G+TP AA+ G+L + L++ G PD +I G T LH+AA G + + L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ GA + + TPL +A+ G E V+ L
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/114 (28%), Positives = 60/114 (52%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++G++ L++E + +++ + G T A+ G E ++++V G + +
Sbjct: 69 HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 128
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPL++AA H+ + +L+ GAN D TPL +A +GH + V L
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 54.7 bits (130), Expect = 2e-07
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPDE--DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ ++E +K + + D D +T AA+ G+ +L++ + +P+ +
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+A + + LV +GA+I + TP+ +AA GH+ V L
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A++ G ++K + +++A DG+TP AA G+ + + L++ RG
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G +PLH+AA H+ C+ L+ A + + DY T L +AA GH + L
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Query: 6 HRAARDGYLELLKEATRKELNA--PDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A+++G+ +++ K N + G+T AA + ++ G D D
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPL +A G++ ++FL+ GAN+ + +TPL AA +GH + L AK
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 124 QSS 126
++
Sbjct: 787 PNA 789
Score = 50.1 bits (118), Expect = 4e-06
Identities = 33/133 (24%), Positives = 65/133 (48%), Gaps = 2/133 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++ + + T+ + +A + G TP + A ++GN++ + ++ +G + +
Sbjct: 700 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 759
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPLH AA GH H ++ L+ GA + +T L +A G++ V L + +
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEE 819
Query: 124 QSSLNPKLVGKLK 136
++ + K K
Sbjct: 820 VTTTTTTITEKHK 832
Score = 48.9 bits (115), Expect = 1e-05
Identities = 34/114 (29%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKE--LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AAR G +E+++ R ++A + TP A+ G E ++L++ PD
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH++A G + S L+ GA TPL +AA G ++ + L
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/114 (32%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G+ + K K N A +G TP A ++ + L+V G
Sbjct: 370 HVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TP+H+AA GHL+ + L+ GA+ + T L MAA G +E VR L
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Score = 46.2 bits (108), Expect = 6e-05
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 6 HRAARDGYLEL---LKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H +AR+G +++ L EA A + G TP AA +G+L+ +L++ R D
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKK-GFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
G TPLH+AA + L+ GA+ + +TPL +AA K M+ L + A
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 123 K 123
+
Sbjct: 654 E 654
Score = 42.7 bits (99), Expect = 7e-04
Identities = 28/101 (27%), Positives = 46/101 (45%)
Query: 26 NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLV 85
+A ++G TP AA ++ +++ G + + G TPLHLA+ GH ++ L+
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 86 SFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSS 126
GANI T L +AA + + L A Q +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Score = 42.4 bits (98), Expect = 9e-04
Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 6 HRAARDGYLELLKEATRKEL-------------NAPDEDGMTPTLWAAYHGNLESLRLIV 52
H A++GY L A + ++ N + G+TP A+ G+ + + L++
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 53 SRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYH-----TPLDMAAM 107
+G + G T LHLAA ++ L GA D D H TPL +A
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-----DQDAHTKLGYTPLIVACH 737
Query: 108 KGHMECVRYL 117
G+++ V +L
Sbjct: 738 YGNVKMVNFL 747
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/86 (25%), Positives = 42/86 (48%), Gaps = 2/86 (2%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N H A+ G E++K ++ +NA ++G TP AA +++ ++ ++ G +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLV 85
G TPL +A GH ++ L+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILL 183
Score = 38.1 bits (87), Expect = 0.017
Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 9/132 (6%)
Query: 6 HRAARDGY---LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AAR G+ +ELL E L A ++G++P AA ++E ++ ++ D
Sbjct: 304 HCAARSGHDQVVELLLERGAPLL-ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHME----CVRYLD 118
+ T LH+AA GH L+ AN + TPL +A K ++ V+Y
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 119 SI-AAKQSSLNP 129
SI A +S L P
Sbjct: 423 SIQAITESGLTP 434
Score = 32.7 bits (73), Expect = 0.71
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 4/104 (3%)
Query: 6 HRAARDGYLELLKEATRKELNAPDE---DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H A+R G E++ + + + PD +G TP +A G ++ +++ G
Sbjct: 502 HIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAA 106
G TPLH+AA G L L+ A + TPL +AA
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 66.2 bits (160), Expect = 6e-11
Identities = 42/127 (33%), Positives = 67/127 (52%), Gaps = 2/127 (1%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N + RAAR G L+ + E + ++N +++G+ AA G++ ++ ++ RG D
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
GNT LH+A+ G + LV GANI + TPL MAA + H++ V+YL
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 120 IAAKQSS 126
A QS+
Sbjct: 152 NGANQST 158
Score = 60.8 bits (146), Expect = 2e-09
Identities = 33/87 (37%), Positives = 49/87 (56%)
Query: 31 DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGAN 90
+G+TP A+ GN ++L++ RGG D G TPLH AA +GH + L+ GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 91 IWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ + +PL MAA H+ECV++L
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 57.8 bits (138), Expect = 2e-08
Identities = 35/114 (30%), Positives = 59/114 (51%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPD--EDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ G L++ K ++ A ++G+TP AA++ N + L++ +G P
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+AA + S L+++GA + TPL +A+ +GH + V L
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 56.2 bits (134), Expect = 6e-08
Identities = 33/93 (35%), Positives = 47/93 (50%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+N E G TP AA++GN+ L+++RG D G TPLH+A+ G+ + + L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ G I D TPL AA GH + V L
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/93 (34%), Positives = 49/93 (52%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+ A E G+TP AA+ G+L + L++ G PD +I G T LH+AA G + + L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ GA + + TPL +A+ G E V+ L
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/114 (28%), Positives = 60/114 (52%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++G++ L++E + +++ + G T A+ G E ++++V G + +
Sbjct: 69 HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 128
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPL++AA H+ + +L+ GAN D TPL +A +GH + V L
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 54.7 bits (130), Expect = 2e-07
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPDE--DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ ++E +K + + D D +T AA+ G+ +L++ + +P+ +
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+A + + LV +GA+I + TP+ +AA GH+ V L
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A++ G ++K + +++A DG+TP AA G+ + + L++ RG
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G +PLH+AA H+ C+ L+ A + + DY T L +AA GH + L
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Query: 6 HRAARDGYLELLKEATRKELNA--PDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A+++G+ +++ K N + G+T AA + ++ G D D
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPL +A G++ ++FL+ GAN+ + +TPL AA +GH + L AK
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 124 QSS 126
++
Sbjct: 787 PNA 789
Score = 50.1 bits (118), Expect = 4e-06
Identities = 33/133 (24%), Positives = 65/133 (48%), Gaps = 2/133 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++ + + T+ + +A + G TP + A ++GN++ + ++ +G + +
Sbjct: 700 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 759
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPLH AA GH H ++ L+ GA + +T L +A G++ V L + +
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEE 819
Query: 124 QSSLNPKLVGKLK 136
++ + K K
Sbjct: 820 VTTTTTTITEKHK 832
Score = 48.9 bits (115), Expect = 1e-05
Identities = 34/114 (29%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKE--LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AAR G +E+++ R ++A + TP A+ G E ++L++ PD
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH++A G + S L+ GA TPL +AA G ++ + L
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/114 (32%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G+ + K K N A +G TP A ++ + L+V G
Sbjct: 370 HVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TP+H+AA GHL+ + L+ GA+ + T L MAA G +E VR L
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Score = 46.2 bits (108), Expect = 6e-05
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 6 HRAARDGYLEL---LKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H +AR+G +++ L EA A + G TP AA +G+L+ +L++ R D
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKK-GFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
G TPLH+AA + L+ GA+ + +TPL +AA K M+ L + A
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 123 K 123
+
Sbjct: 654 E 654
Score = 42.7 bits (99), Expect = 7e-04
Identities = 28/101 (27%), Positives = 46/101 (45%)
Query: 26 NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLV 85
+A ++G TP AA ++ +++ G + + G TPLHLA+ GH ++ L+
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 86 SFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSS 126
GANI T L +AA + + L A Q +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Score = 42.4 bits (98), Expect = 9e-04
Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 6 HRAARDGYLELLKEATRKEL-------------NAPDEDGMTPTLWAAYHGNLESLRLIV 52
H A++GY L A + ++ N + G+TP A+ G+ + + L++
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 53 SRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYH-----TPLDMAAM 107
+G + G T LHLAA ++ L GA D D H TPL +A
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-----DQDAHTKLGYTPLIVACH 737
Query: 108 KGHMECVRYL 117
G+++ V +L
Sbjct: 738 YGNVKMVNFL 747
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/86 (25%), Positives = 42/86 (48%), Gaps = 2/86 (2%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N H A+ G E++K ++ +NA ++G TP AA +++ ++ ++ G +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLV 85
G TPL +A GH ++ L+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILL 183
Score = 38.1 bits (87), Expect = 0.017
Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 9/132 (6%)
Query: 6 HRAARDGY---LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AAR G+ +ELL E L A ++G++P AA ++E ++ ++ D
Sbjct: 304 HCAARSGHDQVVELLLERGAPLL-ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHME----CVRYLD 118
+ T LH+AA GH L+ AN + TPL +A K ++ V+Y
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 119 SI-AAKQSSLNP 129
SI A +S L P
Sbjct: 423 SIQAITESGLTP 434
Score = 32.7 bits (73), Expect = 0.71
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 4/104 (3%)
Query: 6 HRAARDGYLELLKEATRKELNAPDE---DGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H A+R G E++ + + + PD +G TP +A G ++ +++ G
Sbjct: 502 HIASRLGKTEIV-QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAA 106
G TPLH+AA G L L+ A + TPL +AA
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 66.2 bits (160), Expect = 6e-11
Identities = 41/126 (32%), Positives = 67/126 (53%), Gaps = 2/126 (1%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N Y RAAR G+LE + + ++N +++G+ A+ G++E + ++ R + D
Sbjct: 42 NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVD 101
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
GNT LH+A+ G + LV+ GAN+ + TPL MAA + H+E V++L
Sbjct: 102 AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Query: 120 IAAKQS 125
A QS
Sbjct: 162 NGASQS 167
Score = 61.6 bits (148), Expect = 1e-09
Identities = 40/131 (30%), Positives = 63/131 (48%), Gaps = 7/131 (5%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AAR G E+++ + ++ A +D TP +A G + ++ ++ +G P+
Sbjct: 471 HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPLHL+A GH +FL+ GA++ TPL +AA G +E L
Sbjct: 531 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL-----L 585
Query: 124 QSSLNPKLVGK 134
Q S +P GK
Sbjct: 586 QKSASPDAAGK 596
Score = 60.5 bits (145), Expect = 3e-09
Identities = 36/114 (31%), Positives = 62/114 (54%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A+++G++E++ E ++E N A + G T A+ G E ++++V+ G + +
Sbjct: 79 HLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQ 138
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPL++AA HL + FL+ GA+ D TPL +A +GH + V L
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/114 (27%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLEL--LKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++G++++ L +N ++ G+TP AA + ++V++G D
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+ G++ ++FL+ A + + +TPL AA +GH + L
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 55.8 bits (133), Expect = 8e-08
Identities = 29/93 (31%), Positives = 49/93 (52%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+ A E G+TP AA+ G++ + ++ G P+ ++ G T LH+AA +G + +L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
V GA + D TPL ++A G + V+ L
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Score = 53.1 bits (126), Expect = 5e-07
Identities = 33/114 (28%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ G LE+ +K + A + G+TP AA++ N + L++ +G P
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH+AA + + L+ +GA+ + + +AA +GH++ V L
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/114 (27%), Positives = 56/114 (49%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A++ G ++K + +++A DG+TP A G+ + + +++ R
Sbjct: 273 HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G +PLH+A HL+C+ L+ + + NDY T L +AA GH + + L
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 50.4 bits (119), Expect = 3e-06
Identities = 35/131 (26%), Positives = 62/131 (47%), Gaps = 13/131 (9%)
Query: 6 HRAARDGYLELLKEATRKEL-------------NAPDEDGMTPTLWAAYHGNLESLRLIV 52
H AA++GY L A + ++ NA G+ AA G+++ + L++
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Query: 53 SRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHME 112
R + + + G TPLHLAA ++ LV+ GA++ +TPL + G+++
Sbjct: 685 GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIK 744
Query: 113 CVRYLDSIAAK 123
V +L +AK
Sbjct: 745 IVNFLLQHSAK 755
Score = 50.1 bits (118), Expect = 4e-06
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPDED--GMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AAR + + + NA E G TP AA++GN+ L+++R D
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
TPLH+A+ G+ + + L+ GA I D TPL A GH + V L AA
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
Score = 49.7 bits (117), Expect = 6e-06
Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 6/111 (5%)
Query: 6 HRAARDGYLE----LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC 61
H +AR+G+ + LL L+ + G TP AA +G LE L++ + PD
Sbjct: 537 HLSAREGHEDVAAFLLDHGA--SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA 594
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHME 112
G TPLH+AA + L+ GA+ + +TPL +AA K M+
Sbjct: 595 GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645
Score = 49.3 bits (116), Expect = 7e-06
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 6/116 (5%)
Query: 6 HRAARDGYLE----LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC 61
H AA G + LL A + A ++ +TP A+ GN ++L++ RG D
Sbjct: 240 HIAAHYGNINVATLLLNRAAAVDFTARND--ITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPLH A +GH + L+ A I + +PL MA H+ CV+ L
Sbjct: 298 TRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/125 (24%), Positives = 59/125 (47%), Gaps = 2/125 (1%)
Query: 6 HRAARDGYLELLKEATRKELNAPD--EDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A + +L ++ + + D D +T AA+ G+ + ++++ + +P+ +
Sbjct: 339 HMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPLH+A + + L+ GA+I + TP+ +AA GH+ V L A
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 124 QSSLN 128
++ N
Sbjct: 459 PNTTN 463
Score = 43.1 bits (100), Expect = 5e-04
Identities = 30/100 (30%), Positives = 44/100 (44%)
Query: 18 KEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGH 77
K R D L AA G+LE + G D + C+ G LHLA+ GH
Sbjct: 27 KHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGH 86
Query: 78 LHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ +S L+ AN+ +T L +A++ G E V+ L
Sbjct: 87 VEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Score = 40.0 bits (92), Expect = 0.004
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 2 NDQYHRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPD 59
N H A+ G E++K +NA ++G TP AA +LE ++ ++ G
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 60 KCDIWGNTPLHLAASNGHLHCLSFLV 85
G TPL +A GH +S L+
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLL 193
Score = 39.7 bits (91), Expect = 0.006
Identities = 27/111 (24%), Positives = 53/111 (47%), Gaps = 2/111 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++ + + + + ++A + G TP ++GN++ + ++ +
Sbjct: 702 HLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTK 761
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECV 114
G TPLH AA GH H ++ L+ A+ L + +T L +A G++ V
Sbjct: 762 NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 812
Score = 36.2 bits (82), Expect = 0.064
Identities = 28/103 (27%), Positives = 46/103 (44%), Gaps = 2/103 (1%)
Query: 6 HRAARDGYLELLKEATRKEL--NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H +AR G +++++ ++ NA G TP +A G+ + ++ G
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAA 106
G TPLH+AA G L + L+ A+ TPL +AA
Sbjct: 564 KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606
Score = 35.0 bits (79), Expect = 0.14
Identities = 23/85 (27%), Positives = 43/85 (50%)
Query: 39 AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY 98
AA + ++ L++ + D G TPLH+AA G+++ + L++ A + +
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 99 HTPLDMAAMKGHMECVRYLDSIAAK 123
TPL +A+ +G+ V+ L AK
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAK 293
Score = 33.9 bits (76), Expect = 0.32
Identities = 16/61 (26%), Positives = 32/61 (52%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++NA ++G TP AA G+ + +++ P++ + GNT L +A G++ +
Sbjct: 755 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 814
Query: 84 L 84
L
Sbjct: 815 L 815
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 66.2 bits (160), Expect = 6e-11
Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 3/115 (2%)
Query: 6 HRAARDGYLELLKEATRK---ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H AA G+L ++K ++ +NA DG TP AA G+ R+++ D + C
Sbjct: 575 HYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCS 634
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ TPLH+AA GH L+ GA + +D +T L +AA GH+ V+ L
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLL 689
Score = 60.5 bits (145), Expect = 3e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 1/106 (0%)
Query: 12 GYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHL 71
G +ELL A + +NA DED T +AA +G+ S RL++ + ++ D G TP+H+
Sbjct: 485 GVVELLL-ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV 543
Query: 72 AASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
A +G + + L+ G ++ D PL AA +GH+ V+ L
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 50.4 bits (119), Expect = 3e-06
Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 2/116 (1%)
Query: 6 HRAARDGYLELLKEATR--KELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA+ G+ + + ++N TP AA G+ + RL++ RG +
Sbjct: 609 HLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTS 668
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
G T LHLAA NGHL + LV A++ T L +AA GH E V L S
Sbjct: 669 DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS 724
Score = 34.7 bits (78), Expect = 0.19
Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 3/88 (3%)
Query: 6 HRAARDGYLELLKEATRKELNAPDEDGMTPTLW--AAYHGNLESLRLIVSRGGDPDKCDI 63
H AAR+G+L +K ++ + + T AA HG+ E + +VS D D
Sbjct: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS-ADVIDLFDE 733
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANI 91
G + LHLAA H + L+ GA+I
Sbjct: 734 QGLSALHLAAQGRHAQTVETLLRHGAHI 761
Score = 32.3 bits (72), Expect = 0.93
Identities = 26/114 (22%), Positives = 49/114 (42%), Gaps = 3/114 (2%)
Query: 15 ELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAAS 74
+L+K ++++ + G + A G E + ++ +P+ + G+TPLH+A
Sbjct: 421 KLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVE 480
Query: 75 NGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
+ L++ ++ D D T L AA G R L K +S+N
Sbjct: 481 RRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL---LEKNASVN 531
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 66.2 bits (160), Expect = 6e-11
Identities = 62/210 (29%), Positives = 90/210 (42%), Gaps = 46/210 (21%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLW--AAYHGNLESLRLIVSRGGDPDKCDI 63
AA GY E+ + K ++NAP T AA G+ + L++ RG D +
Sbjct: 1292 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL------ 117
GNTPL LAA+ GHL + LV GA++ DN TPL A KGH++ VRYL
Sbjct: 1352 KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQ 1411
Query: 118 ----------------------------------DSIAAKQSSLNPKLVGKLKDKAFREA 143
D AA+ + L+ +L + RE
Sbjct: 1412 FPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREE 1471
Query: 144 ERRIRECAKLQRRHHERMERR--YRRELAE 171
RR+ AK ++R +R +++ RR+L E
Sbjct: 1472 SRRLALAAKREKRKEKRRKKKEEQRRKLEE 1501
Score = 56.6 bits (135), Expect = 5e-08
Identities = 38/113 (33%), Positives = 59/113 (52%), Gaps = 3/113 (2%)
Query: 8 AARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA++G+LEL+K A ++A G T +A +G+ + +++ G D + G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANI-WCLDNDYHTPLDMAAMKGHMECVRYL 117
TPL AA GH+ + FL+S GAN+ N+ HT L +A GH+ V L
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683
Score = 55.5 bits (132), Expect = 1e-07
Identities = 36/120 (30%), Positives = 63/120 (52%), Gaps = 3/120 (2%)
Query: 8 AARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA G+++++K A + ++NA G T +A G ++ +++++ G + + G
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY-HTPLDMAAMKGHMECVRYLDSIAAKQ 124
+TPL A S GH+ L+ GA I N++ + L +A KGH+E VR+L A Q
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 427
Score = 52.4 bits (124), Expect = 9e-07
Identities = 34/113 (30%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 8 AARDGYLELLKEATRKELNAPD---EDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIW 64
A GY EL + N D + +TP + AA G+++ ++L+++ D +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 65 GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
GNT L A + G++ + L+ GA+I + + HTPL A GH+E R L
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/113 (31%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 8 AARDGYLELLKEATRKELNAPD--EDGMTPTLWAAYHGNLESLRLIVSRG-GDPDKCDIW 64
A GY++++K + D E+G TP + A G++E RL++ G G + +
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 65 GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ L LA GHL + FL+ GA+ ++ HT L A M GH+E R L
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/120 (28%), Positives = 58/120 (48%), Gaps = 3/120 (2%)
Query: 1 MNDQYHRAARDGYLELLKEA--TRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDP 58
M+ A DG++E+ + + ++N P + +P AA G++E L++ RG
Sbjct: 434 MHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL 493
Query: 59 DKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC-LDNDYHTPLDMAAMKGHMECVRYL 117
++ + G TPL AA GH ++ L+ GANI + T L +A G +E +L
Sbjct: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
Score = 47.0 bits (110), Expect = 4e-05
Identities = 29/89 (32%), Positives = 44/89 (49%)
Query: 34 TPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC 93
TP + AA G+LE ++ +++ G + G+T L A NGH L+ GA++
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 94 LDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
TPL AA GH+ V++L S A
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGA 654
Score = 46.6 bits (109), Expect = 5e-05
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 34 TPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC 93
TP A G E + L+++RG + + ++ TPL LAAS G+++ + L++ GA I
Sbjct: 1152 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1211
Query: 94 LDNDY--HTPLDMAAMKGHMECVRYL 117
+PL +AAM GH V+ L
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLL 1237
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/90 (28%), Positives = 42/90 (46%)
Query: 39 AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY 98
A Y G+LE +R ++ G D + +T L A +GH+ L+ GA + + +
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 99 HTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
+PL +AA GH+E L A +N
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVN 497
Score = 43.1 bits (100), Expect = 5e-04
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 1/95 (1%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGN-TPLHLAASNGHLHCLS 82
+L E G TP + AA G++ +++ ++S+G + ++ + T L LA + GHL +
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681
Query: 83 FLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L++ GA+ D T L AA GH V YL
Sbjct: 682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Score = 41.6 bits (96), Expect = 0.002
Identities = 33/108 (30%), Positives = 49/108 (45%), Gaps = 6/108 (5%)
Query: 8 AARDGYLEL--LKEATRKELNAPDEDGMTPTLWAAYHGN-LESLRLIVSRGGDPDKCDIW 64
AAR+G+ E+ L +NA E+ L A G LE ++ G D ++
Sbjct: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD---IELG 563
Query: 65 GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHME 112
+TPL AA GHL + +L++ GAN+ T L A GH +
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 2/107 (1%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESL-RLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
+++A E L A G E L + ++ RG + D G TPL LAA+ GH+ +
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 83 FLVSFGANIWC-LDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
L+ GA+I + TPL +A G E V L + A + N
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN 1180
Score = 38.9 bits (89), Expect = 0.010
Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 6/107 (5%)
Query: 14 LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC--DIWGNTPLHL 71
L L + A ++ N D TP AA G + ++++++ G + + G +PL L
Sbjct: 1168 LLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 1224
Query: 72 AASNGHLHCLSFLVSFGANIWC-LDNDYHTPLDMAAMKGHMECVRYL 117
AA NGH + L+ G++I ++ + +T L +A +G E V L
Sbjct: 1225 AAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Score = 32.3 bits (72), Expect = 0.93
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 3/90 (3%)
Query: 24 ELNAPDEDGMTPTLW-AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
++NA E L A + G E + L++ R + + G TPL AAS G+
Sbjct: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
Query: 83 FLVSFGANIWC--LDNDYHTPLDMAAMKGH 110
L+ GA++ + + T L +AA KGH
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGH 1332
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 66.2 bits (160), Expect = 6e-11
Identities = 62/210 (29%), Positives = 90/210 (42%), Gaps = 46/210 (21%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLW--AAYHGNLESLRLIVSRGGDPDKCDI 63
AA GY E+ + K ++NAP T AA G+ + L++ RG D +
Sbjct: 1041 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK 1100
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL------ 117
GNTPL LAA+ GHL + LV GA++ DN TPL A KGH++ VRYL
Sbjct: 1101 KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQ 1160
Query: 118 ----------------------------------DSIAAKQSSLNPKLVGKLKDKAFREA 143
D AA+ + L+ +L + RE
Sbjct: 1161 FPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREE 1220
Query: 144 ERRIRECAKLQRRHHERMERR--YRRELAE 171
RR+ AK ++R +R +++ RR+L E
Sbjct: 1221 SRRLALAAKREKRKEKRRKKKEEQRRKLEE 1250
Score = 56.6 bits (135), Expect = 5e-08
Identities = 38/113 (33%), Positives = 59/113 (52%), Gaps = 3/113 (2%)
Query: 8 AARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA++G+LEL+K A ++A G T +A +G+ + +++ G D + G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANI-WCLDNDYHTPLDMAAMKGHMECVRYL 117
TPL AA GH+ + FL+S GAN+ N+ HT L +A GH+ V L
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683
Score = 55.5 bits (132), Expect = 1e-07
Identities = 36/120 (30%), Positives = 63/120 (52%), Gaps = 3/120 (2%)
Query: 8 AARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA G+++++K A + ++NA G T +A G ++ +++++ G + + G
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY-HTPLDMAAMKGHMECVRYLDSIAAKQ 124
+TPL A S GH+ L+ GA I N++ + L +A KGH+E VR+L A Q
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 427
Score = 52.4 bits (124), Expect = 9e-07
Identities = 34/113 (30%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 8 AARDGYLELLKEATRKELNAPD---EDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIW 64
A GY EL + N D + +TP + AA G+++ ++L+++ D +
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 65 GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
GNT L A + G++ + L+ GA+I + + HTPL A GH+E R L
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/113 (31%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 8 AARDGYLELLKEATRKELNAPD--EDGMTPTLWAAYHGNLESLRLIVSRG-GDPDKCDIW 64
A GY++++K + D E+G TP + A G++E RL++ G G + +
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 65 GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ L LA GHL + FL+ GA+ ++ HT L A M GH+E R L
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/120 (28%), Positives = 58/120 (48%), Gaps = 3/120 (2%)
Query: 1 MNDQYHRAARDGYLELLKEA--TRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDP 58
M+ A DG++E+ + + ++N P + +P AA G++E L++ RG
Sbjct: 434 MHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASL 493
Query: 59 DKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC-LDNDYHTPLDMAAMKGHMECVRYL 117
++ + G TPL AA GH ++ L+ GANI + T L +A G +E +L
Sbjct: 494 EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFL 553
Score = 47.0 bits (110), Expect = 4e-05
Identities = 29/89 (32%), Positives = 44/89 (49%)
Query: 34 TPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC 93
TP + AA G+LE ++ +++ G + G+T L A NGH L+ GA++
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 94 LDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
TPL AA GH+ V++L S A
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGA 654
Score = 46.6 bits (109), Expect = 5e-05
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 34 TPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC 93
TP A G E + L+++RG + + ++ TPL LAAS G+++ + L++ GA I
Sbjct: 901 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960
Query: 94 LDNDY--HTPLDMAAMKGHMECVRYL 117
+PL +AAM GH V+ L
Sbjct: 961 RTGSKLGISPLMLAAMNGHTAAVKLL 986
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/90 (28%), Positives = 42/90 (46%)
Query: 39 AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY 98
A Y G+LE +R ++ G D + +T L A +GH+ L+ GA + + +
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 99 HTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
+PL +AA GH+E L A +N
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVN 497
Score = 43.1 bits (100), Expect = 5e-04
Identities = 30/95 (31%), Positives = 49/95 (51%), Gaps = 1/95 (1%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGN-TPLHLAASNGHLHCLS 82
+L E G TP + AA G++ +++ ++S+G + ++ + T L LA + GHL +
Sbjct: 622 DLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681
Query: 83 FLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L++ GA+ D T L AA GH V YL
Sbjct: 682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Score = 41.6 bits (96), Expect = 0.002
Identities = 33/108 (30%), Positives = 49/108 (45%), Gaps = 6/108 (5%)
Query: 8 AARDGYLEL--LKEATRKELNAPDEDGMTPTLWAAYHGN-LESLRLIVSRGGDPDKCDIW 64
AAR+G+ E+ L +NA E+ L A G LE ++ G D ++
Sbjct: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD---IELG 563
Query: 65 GNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHME 112
+TPL AA GHL + +L++ GAN+ T L A GH +
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 2/107 (1%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESL-RLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
+++A E L A G E L + ++ RG + D G TPL LAA+ GH+ +
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 83 FLVSFGANIWC-LDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
L+ GA+I + TPL +A G E V L + A + N
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN 929
Score = 38.9 bits (89), Expect = 0.010
Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 6/107 (5%)
Query: 14 LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC--DIWGNTPLHL 71
L L + A ++ N D TP AA G + ++++++ G + + G +PL L
Sbjct: 917 LLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 973
Query: 72 AASNGHLHCLSFLVSFGANIWC-LDNDYHTPLDMAAMKGHMECVRYL 117
AA NGH + L+ G++I ++ + +T L +A +G E V L
Sbjct: 974 AAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Score = 32.3 bits (72), Expect = 0.93
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 3/90 (3%)
Query: 24 ELNAPDEDGMTPTLW-AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
++NA E L A + G E + L++ R + + G TPL AAS G+
Sbjct: 992 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051
Query: 83 FLVSFGANIWC--LDNDYHTPLDMAAMKGH 110
L+ GA++ + + T L +AA KGH
Sbjct: 1052 VLLDKGADVNAPPVPSSRDTALTIAADKGH 1081
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 65.5 bits (158), Expect = 1e-10
Identities = 37/83 (44%), Positives = 49/83 (59%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
E++ PD+ G T AA GN+E ++L+ S G D K D G TPLH AA+N H HC+
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 84 LVSFGANIWCLDNDYHTPLDMAA 106
LV+ GAN+ D+ T L AA
Sbjct: 432 LVTTGANVNETDDWGRTALHYAA 454
Score = 63.5 bits (153), Expect = 4e-10
Identities = 46/130 (35%), Positives = 66/130 (50%), Gaps = 5/130 (3%)
Query: 6 HRAARDGY---LELLKEATRKELNAPDEDGM-TPTLWAAYHGNLESLRLIVSRGGDPDKC 61
H AA G+ LELL E T D +P AAY+G+ ++L +++ D D
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDN-DYHTPLDMAAMKGHMECVRYLDSI 120
D G T L LAA GH C+ L++ GA+I+ DN TPL + + GH C+R L I
Sbjct: 572 DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEI 631
Query: 121 AAKQSSLNPK 130
A +++ K
Sbjct: 632 ADNPEAVDVK 641
Score = 62.8 bits (151), Expect = 6e-10
Identities = 38/99 (38%), Positives = 51/99 (51%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
E++ D+DG TP AA +G+ + + + G D KC I PLHLAA N H C
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
L+S G I D T L AA G++EC++ L S A
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Score = 62.0 bits (149), Expect = 1e-09
Identities = 32/104 (30%), Positives = 56/104 (53%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+N D G T AA +G++E + L++++G + + D LH AA GHL ++ L
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
++ GA + C D +TPL AA G + V++L ++ + +N
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN 211
Score = 60.1 bits (144), Expect = 4e-09
Identities = 39/125 (31%), Positives = 63/125 (50%), Gaps = 2/125 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA +G++E++ K +NA D+ WAAY G+L+ + L+++ G + D
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPLH AASNG ++ + L++ G I ++ +T L +A G V L A
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
Query: 124 QSSLN 128
+ N
Sbjct: 240 VNQPN 244
Score = 59.3 bits (142), Expect = 7e-09
Identities = 32/96 (33%), Positives = 51/96 (53%), Gaps = 1/96 (1%)
Query: 16 LLKEATRKE-LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAAS 74
LL+ A E ++ D G TP + A +G+++++ L++ + + D DI G T LH
Sbjct: 628 LLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIM 687
Query: 75 NGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGH 110
GH C+ L+ +I C D+ TPL AA +GH
Sbjct: 688 TGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
Score = 58.9 bits (141), Expect = 9e-09
Identities = 34/107 (31%), Positives = 60/107 (56%), Gaps = 2/107 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G+L+++ E+ D+ G TP AA +G + ++ +++ G + D+ ++
Sbjct: 153 HWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINV 212
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGH 110
+GNT LH+A NG ++ L+ +GAN+ +N+ TPL AA H
Sbjct: 213 YGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTH 259
Score = 58.5 bits (140), Expect = 1e-08
Identities = 32/94 (34%), Positives = 48/94 (51%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++N +DG +P A HG + ++ GG+ D D GNTPLH+AA GH ++
Sbjct: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L + GA+ PL +AA+ H +C R L
Sbjct: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
Score = 58.5 bits (140), Expect = 1e-08
Identities = 63/230 (27%), Positives = 94/230 (40%), Gaps = 12/230 (5%)
Query: 2 NDQYHRAARDGYLELLKEATRKELNAPDEDG---MTPTLWAAYHGNLESLRLIVSRGGDP 58
N H AAR G+ ELL R + G M P AA + + + R ++S G +
Sbjct: 315 NTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEI 373
Query: 59 DKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLD 118
D D +G T LH AA+ G++ C+ L S GA+ D TPL AA H C+ L
Sbjct: 374 DTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
Query: 119 SIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSF 178
+ A + + L A + + R L H E REL E+ TL
Sbjct: 434 TTGANVNETDDWGRTALHYAAASDMD---RNKTILGNAHDNSEELERARELKEKEATLCL 490
Query: 179 SSLTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGE 228
L + + ++ + + Y+ A H + ++ LER G E
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGH-----RQCLELLLERTNSGFE 535
Score = 57.0 bits (136), Expect = 4e-08
Identities = 41/123 (33%), Positives = 58/123 (47%), Gaps = 16/123 (13%)
Query: 6 HRAARDGYLELLKEATRKELNAPD-----EDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
H AA G+ L E + L+ D G TP WA Y+GN + +++ + K
Sbjct: 716 HYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ-----K 770
Query: 61 C--DIWGN--TPLHLAASNGHLHCLSFLVSF--GANIWCLDNDYHTPLDMAAMKGHMECV 114
C GN TPLH A N H +C S L+ + + C D+ TPL AA H+EC+
Sbjct: 771 CFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECL 830
Query: 115 RYL 117
+ L
Sbjct: 831 QLL 833
Score = 55.8 bits (133), Expect = 8e-08
Identities = 34/103 (33%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLV-SF 87
D+ G TP AA+ ++E L+L++ + D G T L +AA NG + LV S
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 88 GANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPK 130
A++ D D +TPL +A KGH +C + +S +N K
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/88 (38%), Positives = 48/88 (54%), Gaps = 3/88 (3%)
Query: 25 LNAPDEDGMTPTLWAAY--HGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
+N P+ +G TP +AA HG L L L+V+ G D + G +PLH+ A +G
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Query: 83 FLVSFGANIWCLDNDYHTPLDMAAMKGH 110
L+ G I C+D D +TPL +AA GH
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGH 326
Score = 54.3 bits (129), Expect = 2e-07
Identities = 34/91 (37%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNT--PLHLAASNGHLHCLSFLVS 86
D++G +AA +G+ + L L++ R + G T PLHLAA NGH L L+
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563
Query: 87 FGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
++ D T LD+AA KGH ECV L
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
Score = 51.2 bits (121), Expect = 2e-06
Identities = 33/107 (30%), Positives = 54/107 (50%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++NA D++ TP AA + ++ +I+ + D G T LH AA NGH+ ++
Sbjct: 74 DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNL 133
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPK 130
L++ GANI D L AA GH++ V L + A+ + + K
Sbjct: 134 LLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 3/104 (2%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
+NA D +TP A + E++++++ D + D TPLH+AA+N + C +
Sbjct: 42 VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
+ +++ D T L AA+ GH+E V L AK +++N
Sbjct: 102 IPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL---LAKGANIN 142
Score = 47.8 bits (112), Expect = 2e-05
Identities = 30/87 (34%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Query: 34 TPTLWAAYHGNLESLRLIVSRGGDPDKCDIW---GNTPLHLAASNGHLHCLSFLVSFGAN 90
TP + +G+ LRL++ +P+ D+ G TPL LA + GH+ +S L+ AN
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 91 IWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ +D T L M GH ECV+ L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQML 697
Score = 46.2 bits (108), Expect = 6e-05
Identities = 25/95 (26%), Positives = 47/95 (49%)
Query: 23 KELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLS 82
+++N D + TP AA+ G+ E + L++ G + D TPLH A ++ +
Sbjct: 7 EDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQ 66
Query: 83 FLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L+ A++ D ++ TPL +AA ++C +
Sbjct: 67 VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Score = 36.2 bits (82), Expect = 0.064
Identities = 21/68 (30%), Positives = 32/68 (47%)
Query: 50 LIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKG 109
+++ + D + D TPLH+AA G + L+ GA + DN + TPL A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 110 HMECVRYL 117
E V+ L
Sbjct: 61 SEEAVQVL 68
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 65.5 bits (158), Expect = 1e-10
Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 10/135 (7%)
Query: 27 APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVS 86
A D+ G T +A+ +GN + ++L++ G DP++ D GNTPLHLAA H+ ++ L+
Sbjct: 138 AADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLR 197
Query: 87 FGANIWCLDNDYHTPLDMAAMK------GHMECVRYLDSIAAKQSSLNPKLVGKLKDKAF 140
GA + LD TPL +A K GH +C L+++ + + L L+
Sbjct: 198 GGARVDALDRAGRTPLHLAKSKLNILQEGHAQC---LEAVRLEVKQIIHMLREYLERLGQ 254
Query: 141 REAERRIRE-CAKLQ 154
E R+ + C +LQ
Sbjct: 255 HEQRERLDDLCTRLQ 269
Score = 50.1 bits (118), Expect = 4e-06
Identities = 42/157 (26%), Positives = 71/157 (45%), Gaps = 10/157 (6%)
Query: 39 AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDY 98
+A ++E+++ ++ G DP D G T LH A+ NG+ + L+ GA+ D
Sbjct: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
Query: 99 HTPLDMAAMKGHMECVRYLDSIAAKQSSLN-----PKLVGKLKDKAFREAERRIRECAKL 153
+TPL +AA H+ + L A+ +L+ P + K K +E + E +L
Sbjct: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRL 236
Query: 154 QRRH-----HERMERRYRRELAERSDTLSFSSLTSST 185
+ + E +ER + E ER D L +ST
Sbjct: 237 EVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTST 273
Score = 32.3 bits (72), Expect = 0.93
Identities = 22/62 (35%), Positives = 27/62 (43%), Gaps = 6/62 (9%)
Query: 26 NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAAS------NGHLH 79
N D G TP AA ++ + ++ G D D G TPLHLA S GH
Sbjct: 170 NQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQ 229
Query: 80 CL 81
CL
Sbjct: 230 CL 231
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 65.1 bits (157), Expect = 1e-10
Identities = 36/99 (36%), Positives = 54/99 (54%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
LN D G + A + G+LE++ L++++G + CD PLH AA GHL L L
Sbjct: 133 LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
V+ GA++ C D + L AA G +E V+YL + A+
Sbjct: 193 VARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231
Score = 59.3 bits (142), Expect = 7e-09
Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 5/128 (3%)
Query: 6 HRAARDGYLE----LLKEATRKEL-NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDK 60
H AA G+ + L+ R ++ + D G TP + A +G+++ + L++ +G D
Sbjct: 657 HAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716
Query: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
D+ G T LH A G CL+ L+ A + C D TP+ +A+ GH +R L
Sbjct: 717 ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776
Query: 121 AAKQSSLN 128
A L+
Sbjct: 777 ALSTDPLD 784
Score = 58.9 bits (141), Expect = 9e-09
Identities = 35/83 (42%), Positives = 46/83 (55%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++N PD G T AA GN+E L L++S G D + D +G TPLH AA+NG C
Sbjct: 415 DINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVT 474
Query: 84 LVSFGANIWCLDNDYHTPLDMAA 106
LV+ GA + D +PL AA
Sbjct: 475 LVTAGAGVNEADCKGCSPLHYAA 497
Score = 57.0 bits (136), Expect = 4e-08
Identities = 31/94 (32%), Positives = 50/94 (53%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++N ++G +P AA HG ++++ G + D D +GNTPLH+AA GH +S
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
L++ GA+ PL +A + G +C R L
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKL 391
Score = 56.2 bits (134), Expect = 6e-08
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H A G+LE + K LN D+ P WAA+ G+LE L+L+V+RG D D
Sbjct: 145 HHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDR 204
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANI 91
G LH AA++G + + +L+ GA I
Sbjct: 205 KGYGLLHTAAASGQIEVVKYLLRMGAEI 232
Score = 55.5 bits (132), Expect = 1e-07
Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 10/120 (8%)
Query: 6 HRAARDGYLELLKEA--TRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDP---DK 60
H AA +G+ E LK T L+ D G T A G+ E + ++ + G ++
Sbjct: 590 HLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649
Query: 61 CDIWGNTPLHLAASNGHLHCLSFLVSFG--ANIWCLDNDY-HTPLDMAAMKGHMECVRYL 117
W TPLH AA++GH L L+ G A+I + + Y TPL +A M GH++CV L
Sbjct: 650 KRKW--TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/99 (34%), Positives = 51/99 (51%), Gaps = 1/99 (1%)
Query: 16 LLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASN 75
LL K +N+ D G TP AA+ N+ LR+++ + + D G T L AA N
Sbjct: 842 LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAEN 901
Query: 76 GHLHCLSFLVSFG-ANIWCLDNDYHTPLDMAAMKGHMEC 113
G + FL+ G A++ LD + +T L +A KGH +C
Sbjct: 902 GQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940
Score = 52.4 bits (124), Expect = 9e-07
Identities = 33/107 (30%), Positives = 58/107 (54%), Gaps = 3/107 (2%)
Query: 22 RKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCL 81
++ +N D++ TP AAY G++ L+L++ G + + D TPLH AA++ + L
Sbjct: 31 KENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVL 90
Query: 82 SFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
L++ A++ D + TPL +AA +C +++A SSLN
Sbjct: 91 GLLLAHSADVNARDKLWQTPLHVAAANRATKCA---EALAPLLSSLN 134
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 25 LNAPDEDGMTPTLWAAYHGN-LESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
+N P++ G TP AA N L L+V+ G D + G +PLH+AA +G
Sbjct: 265 VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQI 324
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGH 110
L+ G+ I C D +TPL +AA GH
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGH 351
Score = 48.9 bits (115), Expect = 1e-05
Identities = 33/96 (34%), Positives = 47/96 (48%)
Query: 51 IVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGH 110
++S G D + D G T LH AAS G++ CL+ L+S GA++ D TPL AA G
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
Query: 111 MECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERR 146
+C L + A + + K L A + RR
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRR 504
Score = 48.5 bits (114), Expect = 1e-05
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 6 HRAARDGYLELLKEATRKEL--------------NAPDEDGMTPTLWAAYHGNLESLRLI 51
H A D E LKE+ RKE + D G T +AA +GN ++L L+
Sbjct: 513 HDAEED---EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELL 569
Query: 52 VSRGGD--PDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKG 109
+ + D +PLHLAA NGH L L N+ D+ T L +A +G
Sbjct: 570 LEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERG 629
Query: 110 HMECVRYLDSIAA 122
ECV L + A
Sbjct: 630 STECVEVLTAHGA 642
Score = 44.3 bits (103), Expect = 2e-04
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 5/125 (4%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G + +L+ +NA D +TP AA N + L L+++ D + D
Sbjct: 46 HAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDK 105
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
TPLH+AA+N C L +++ D + L A GH+E V L K
Sbjct: 106 LWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLL---LNK 162
Query: 124 QSSLN 128
+SLN
Sbjct: 163 GASLN 167
Score = 44.3 bits (103), Expect = 2e-04
Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 2/136 (1%)
Query: 6 HRAA--RDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
HRAA R+ + L A ++NA D+ TP AA + + + + D
Sbjct: 79 HRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADR 138
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G + LH A +GHL ++ L++ GA++ D PL AA GH+E ++ L + A
Sbjct: 139 SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198
Query: 124 QSSLNPKLVGKLKDKA 139
+ K G L A
Sbjct: 199 LGCKDRKGYGLLHTAA 214
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 33 MTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIW 92
++P AAY+G+ E+L+ + + D D G T L LA G C+ L + GA+
Sbjct: 586 VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Query: 93 CLDNDYH-TPLDMAAMKGHMECVRYL 117
+ TPL AA GH + + L
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLL 671
Score = 38.5 bits (88), Expect = 0.013
Identities = 24/72 (33%), Positives = 38/72 (52%)
Query: 35 PTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCL 94
P + A + ++E +R ++S+ + + D TPLH AA G + L L+ GAN+
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 95 DNDYHTPLDMAA 106
D + TPL AA
Sbjct: 71 DTLWLTPLHRAA 82
Score = 38.1 bits (87), Expect = 0.017
Identities = 35/142 (24%), Positives = 58/142 (40%), Gaps = 30/142 (21%)
Query: 6 HRAARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G +E L ++ +L D+ G TP +AA +G+ + +V+ G ++ D
Sbjct: 428 HAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADC 487
Query: 64 WGNTPLHLAASNG----------------------------HLHCLSFLVSFGANIWCLD 95
G +PLH AA++ CL FL+ GA+ D
Sbjct: 488 KGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547
Query: 96 NDYHTPLDMAAMKGHMECVRYL 117
+T + AA G+ + + L
Sbjct: 548 RQGYTAVHYAAAYGNRQNLELL 569
Score = 37.7 bits (86), Expect = 0.022
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 18/117 (15%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAA---------- 73
E++ D+ G TP AA +G+ + +++ G D + I PLHLA
Sbjct: 331 EIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRK 390
Query: 74 --SNGHLHCL------SFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
S+G L+ + ++S G +I DN T L AA G++EC+ L S A
Sbjct: 391 LLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGA 447
Score = 36.6 bits (83), Expect = 0.049
Identities = 29/105 (27%), Positives = 48/105 (45%), Gaps = 4/105 (3%)
Query: 14 LELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNT---PLH 70
+E L + +L DE+ T A G+ + +I++ D + + PLH
Sbjct: 907 VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
Query: 71 LAASNGHLHCLSFLVSFGANIWCLDNDYHTP-LDMAAMKGHMECV 114
+AA NG + L+S GA + +D + HTP L A K +C+
Sbjct: 967 IAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCL 1011
Score = 33.9 bits (76), Expect = 0.32
Identities = 35/152 (23%), Positives = 55/152 (36%), Gaps = 40/152 (26%)
Query: 6 HRAARDGYLELLKEATRKELNAP------DEDGMTPTLWAAYHGNLESLRLIVSRG---- 55
H A+ G+ +L+ + L+ D G +P WA+Y G+ + L L++
Sbjct: 759 HLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSY 818
Query: 56 --GDP----------------------------DKCDIWGNTPLHLAASNGHLHCLSFLV 85
G+P + D G TPLH AA ++ L L+
Sbjct: 819 LEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLL 878
Query: 86 SFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
A + D+ T L AA G V +L
Sbjct: 879 QHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
Score = 31.2 bits (69), Expect = 2.1
Identities = 24/83 (28%), Positives = 36/83 (43%), Gaps = 5/83 (6%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIW----GNTPLHLAASNGHLHCLSFL 84
D G TP A+ G+ LR ++ D D G +P+H A+ GH CL L
Sbjct: 751 DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
Query: 85 VSFGANIWCLDNDYHTPLDMAAM 107
+ + L+ + TPL A +
Sbjct: 811 LEHSPFSY-LEGNPFTPLHCAVI 832
>gi|4506499 regulatory factor X-associated ankyrin-containing
protein isoform a [Homo sapiens]
Length = 260
Score = 64.7 bits (156), Expect = 2e-10
Identities = 39/115 (33%), Positives = 59/115 (51%), Gaps = 3/115 (2%)
Query: 6 HRAARDGYLELLKEATRKE---LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCD 62
H+ A G L+ LKE RK +N PDE G TP +WA+ G +E++R ++ G DP
Sbjct: 95 HQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILA 154
Query: 63 IWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ L LA++ G+ + L+ +I D + TPL A H++CV L
Sbjct: 155 KERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 209
Score = 31.2 bits (69), Expect = 2.1
Identities = 19/72 (26%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 8 AARDGYLELLKEATRKE--LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
A+ GY +++ ++ +N D +G TP L+A +++ + +++RG D G
Sbjct: 164 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 223
Query: 66 NTPLHLAASNGH 77
TP+ LA + G+
Sbjct: 224 YTPMDLAVALGY 235
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 64.3 bits (155), Expect = 2e-10
Identities = 35/86 (40%), Positives = 50/86 (58%)
Query: 32 GMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANI 91
G+ P AA G+ + +RL++ RG D + D G TPL +AA GHL + FL+S GA +
Sbjct: 1104 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 1163
Query: 92 WCLDNDYHTPLDMAAMKGHMECVRYL 117
LD + + L A +KGH V+YL
Sbjct: 1164 SSLDKEGLSALSWACLKGHRAVVQYL 1189
Score = 62.4 bits (150), Expect = 8e-10
Identities = 38/112 (33%), Positives = 59/112 (52%), Gaps = 2/112 (1%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AAR G+ ++++ + ++N D+ G TP + AA G+L ++ ++S+G D G
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ L A GH + +LV GA I D + TPLD+AA G E V YL
Sbjct: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1222
Score = 52.4 bits (124), Expect = 9e-07
Identities = 35/102 (34%), Positives = 48/102 (47%), Gaps = 7/102 (6%)
Query: 34 TPTLW-------AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVS 86
T TLW AA G LE L++ G + + G PL AA GH + L+
Sbjct: 1066 TDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE 1125
Query: 87 FGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
G ++ D TPL +AA +GH+ V +L S A SSL+
Sbjct: 1126 RGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1167
Score = 49.3 bits (116), Expect = 7e-06
Identities = 33/100 (33%), Positives = 52/100 (52%), Gaps = 2/100 (2%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA +G+L ++ K L++ D++G++ WA G+ ++ +V G D+ D G
Sbjct: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMA 105
TPL LAA G + +LV GA I +D+ PLD A
Sbjct: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1243
Score = 34.3 bits (77), Expect = 0.24
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 1/84 (1%)
Query: 35 PTLWAAYH-GNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC 93
P L H G+ E + L++ G D G T L AA+ GH+ + L G +
Sbjct: 929 PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 988
Query: 94 LDNDYHTPLDMAAMKGHMECVRYL 117
LD L +A++GH + ++YL
Sbjct: 989 LDKKGQCALVHSALRGHGDILQYL 1012
Score = 33.9 bits (76), Expect = 0.32
Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 8/95 (8%)
Query: 41 YHGNLESLRLIVSRGGDPD-KCDIWGNTPLHLAASN-GHLHCLSFLVSFGANIWCLDNDY 98
Y N++ RL++ G + + + ++ N P+ S+ GH ++ L+ FGA CLD
Sbjct: 901 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA---CLDGTS 957
Query: 99 H---TPLDMAAMKGHMECVRYLDSIAAKQSSLNPK 130
T L AA GHM+ V L + L+ K
Sbjct: 958 ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKK 992
Score = 30.4 bits (67), Expect = 3.5
Identities = 18/67 (26%), Positives = 34/67 (50%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
++ D++G TP AA++G+ E++ +V +G + D G PL A + + L
Sbjct: 1196 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1255
Query: 85 VSFGANI 91
+ GA +
Sbjct: 1256 LRKGAKL 1262
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 64.3 bits (155), Expect = 2e-10
Identities = 35/86 (40%), Positives = 50/86 (58%)
Query: 32 GMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANI 91
G+ P AA G+ + +RL++ RG D + D G TPL +AA GHL + FL+S GA +
Sbjct: 1112 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 1171
Query: 92 WCLDNDYHTPLDMAAMKGHMECVRYL 117
LD + + L A +KGH V+YL
Sbjct: 1172 SSLDKEGLSALSWACLKGHRAVVQYL 1197
Score = 62.4 bits (150), Expect = 8e-10
Identities = 38/112 (33%), Positives = 59/112 (52%), Gaps = 2/112 (1%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AAR G+ ++++ + ++N D+ G TP + AA G+L ++ ++S+G D G
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ L A GH + +LV GA I D + TPLD+AA G E V YL
Sbjct: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1230
Score = 52.4 bits (124), Expect = 9e-07
Identities = 35/102 (34%), Positives = 48/102 (47%), Gaps = 7/102 (6%)
Query: 34 TPTLW-------AAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVS 86
T TLW AA G LE L++ G + + G PL AA GH + L+
Sbjct: 1074 TDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLE 1133
Query: 87 FGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
G ++ D TPL +AA +GH+ V +L S A SSL+
Sbjct: 1134 RGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1175
Score = 49.3 bits (116), Expect = 7e-06
Identities = 33/100 (33%), Positives = 52/100 (52%), Gaps = 2/100 (2%)
Query: 8 AARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA +G+L ++ K L++ D++G++ WA G+ ++ +V G D+ D G
Sbjct: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
Query: 66 NTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMA 105
TPL LAA G + +LV GA I +D+ PLD A
Sbjct: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1251
Score = 34.3 bits (77), Expect = 0.24
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 1/84 (1%)
Query: 35 PTLWAAYH-GNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC 93
P L H G+ E + L++ G D G T L AA+ GH+ + L G +
Sbjct: 937 PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 996
Query: 94 LDNDYHTPLDMAAMKGHMECVRYL 117
LD L +A++GH + ++YL
Sbjct: 997 LDKKGQCALVHSALRGHGDILQYL 1020
Score = 33.9 bits (76), Expect = 0.32
Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 8/95 (8%)
Query: 41 YHGNLESLRLIVSRGGDPD-KCDIWGNTPLHLAASN-GHLHCLSFLVSFGANIWCLDNDY 98
Y N++ RL++ G + + + ++ N P+ S+ GH ++ L+ FGA CLD
Sbjct: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA---CLDGTS 965
Query: 99 H---TPLDMAAMKGHMECVRYLDSIAAKQSSLNPK 130
T L AA GHM+ V L + L+ K
Sbjct: 966 ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKK 1000
Score = 30.4 bits (67), Expect = 3.5
Identities = 18/67 (26%), Positives = 34/67 (50%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
++ D++G TP AA++G+ E++ +V +G + D G PL A + + L
Sbjct: 1204 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1263
Query: 85 VSFGANI 91
+ GA +
Sbjct: 1264 LRKGAKL 1270
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 63.5 bits (153), Expect = 4e-10
Identities = 33/90 (36%), Positives = 50/90 (55%)
Query: 28 PDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSF 87
P+ G P G+ + + L+++ G D + D G TPL +AAS GHL + FL++
Sbjct: 1063 PNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQ 1122
Query: 88 GANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
GA+I +D + T L A +KGH+ VR L
Sbjct: 1123 GASIALMDKEGLTALSWACLKGHLSVVRSL 1152
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/94 (35%), Positives = 49/94 (52%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
++N D+ G TP + AA G+L ++ ++++G D G T L A GHL +
Sbjct: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRS 1151
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
LV GA D + TPLD+AA G E V++L
Sbjct: 1152 LVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1185
Score = 53.9 bits (128), Expect = 3e-07
Identities = 31/77 (40%), Positives = 39/77 (50%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFG 88
D++G+T WA G+L +R +V G D D G TPL LAA G + FLV G
Sbjct: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG 1189
Query: 89 ANIWCLDNDYHTPLDMA 105
A I +D PLD A
Sbjct: 1190 AMIEHVDYSGMRPLDRA 1206
Score = 51.2 bits (121), Expect = 2e-06
Identities = 38/122 (31%), Positives = 57/122 (46%), Gaps = 12/122 (9%)
Query: 8 AARDGYLELL-----------KEATRKELNAPDED-GMTPTLWAAYHGNLESLRLIVSRG 55
AA GY E++ +E R ++N+ D G T AA G LE RL++ +G
Sbjct: 998 AASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQG 1057
Query: 56 GDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVR 115
+ + G PL GH + L++ GA++ D TPL MAA +GH+ V
Sbjct: 1058 AAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVD 1117
Query: 116 YL 117
+L
Sbjct: 1118 FL 1119
Score = 41.2 bits (95), Expect = 0.002
Identities = 28/84 (33%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 35 PTLWAAYH-GNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWC 93
P L H G E + L++ G + D G TPL AA+ G+L + L A +
Sbjct: 887 PILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDH 946
Query: 94 LDNDYHTPLDMAAMKGHMECVRYL 117
LD + L AA++GH+E V++L
Sbjct: 947 LDKNGQCALVHAALRGHLEVVKFL 970
Score = 37.0 bits (84), Expect = 0.038
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 7/106 (6%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
++A E G+TP +AA G L + L+ + D D G L AA GHL + FL
Sbjct: 911 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
Query: 85 VSFG-------ANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
+ ++ + L AA G+ E V YL + K
Sbjct: 971 IQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEK 1016
Score = 35.8 bits (81), Expect = 0.084
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
Query: 41 YHGNLESLRLIVSRGGDPD-KCDIWGNTPLHLAASN-GHLHCLSFLVSFGANIWCLDNDY 98
Y N++ RL++ G + + + ++ N P+ S+ G+ ++ L+ FGAN+
Sbjct: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918
Query: 99 HTPLDMAAMKGHMECVRYLDSIAAKQSSLN 128
TPL AA G++ V L AK L+
Sbjct: 919 LTPLGYAAAAGYLSIVVLLCKKRAKVDHLD 948
Score = 32.0 bits (71), Expect = 1.2
Identities = 19/63 (30%), Positives = 31/63 (49%)
Query: 29 DEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFG 88
D++G TP AA++G+ E ++ +V G + D G PL A + + L+ G
Sbjct: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1222
Query: 89 ANI 91
A I
Sbjct: 1223 AKI 1225
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 63.5 bits (153), Expect = 4e-10
Identities = 39/114 (34%), Positives = 60/114 (52%), Gaps = 3/114 (2%)
Query: 7 RAARDGYLELLKEATRKE---LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
+AA G + LL +E +N EDG + AA +G+ + +RL++S + D
Sbjct: 716 QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK 775
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPL AA+ GH C+ L+S+ ANI + TPL +A G+ EC++ L
Sbjct: 776 NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Score = 60.5 bits (145), Expect = 3e-09
Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 2/114 (1%)
Query: 6 HRAARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
+ AA++G+ + ++ + ++NA D++G TP AA G+ E + L++S + +
Sbjct: 749 YSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAAD 808
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
G TPL+LA NG+ C+ L+ G N D TP+ A G+++ ++ L
Sbjct: 809 GGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Score = 51.6 bits (122), Expect = 1e-06
Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 3/91 (3%)
Query: 35 PTLW--AAYHGNLESLRLIVSRGG-DPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANI 91
PTL AA GN+ L ++++ G D + G++ L+ AA NGH C+ L+S A +
Sbjct: 711 PTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 92 WCLDNDYHTPLDMAAMKGHMECVRYLDSIAA 122
D + TPL AA +GH ECV L S A
Sbjct: 771 NAADKNGFTPLCAAAAQGHFECVELLISYDA 801
Score = 35.4 bits (80), Expect = 0.11
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 2/80 (2%)
Query: 8 AARDGYLELLKEATRKE--LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
AA G+ E ++ + +N + G TP A +GN E ++L++ G + G
Sbjct: 784 AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG 843
Query: 66 NTPLHLAASNGHLHCLSFLV 85
TP+H A G++ L L+
Sbjct: 844 WTPVHAAVDTGNVDSLKLLM 863
Score = 32.7 bits (73), Expect = 0.71
Identities = 23/58 (39%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 67 TPLHLAASNGHLHCLSFLVSF-GANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
T L AA+ G++ LS L++ G +I D H+ L AA GH +CVR L S A+
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ 769
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 63.2 bits (152), Expect = 5e-10
Identities = 38/117 (32%), Positives = 59/117 (50%)
Query: 25 LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
++A + +G TP AA + RL+VSR DP+ + G TPLH+AA GH+ + L
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
Query: 85 VSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFR 141
S GA + + TPL +A +G + +++L A +L+ G L A R
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
Score = 62.4 bits (150), Expect = 8e-10
Identities = 40/124 (32%), Positives = 62/124 (50%), Gaps = 2/124 (1%)
Query: 6 HRAARDGYLELLKEATRK--ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G++ L+K T + EL+A + TP A G + +++ ++ G PD D
Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ 558
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G PLH AA+ G L+ +GA++ + TPL +AA KGH+E + L A
Sbjct: 559 SGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN 618
Query: 124 QSSL 127
+L
Sbjct: 619 MGAL 622
Score = 56.6 bits (135), Expect = 5e-08
Identities = 37/100 (37%), Positives = 53/100 (53%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
+ N DEDG P +AA +G+ + RL++ G D + G TPLHLAA N +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
LVS A+ + + TPL +AA GH+ V+ L S A+
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519
Score = 51.6 bits (122), Expect = 1e-06
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 2/106 (1%)
Query: 6 HRAARDGYLELLKEATRKEL--NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA++ + + + ++ N + +G TP AAY G++ ++L+ S+G + D
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKG 109
TPLHLA G + + L+ GA LD + PL AA +G
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
Score = 48.5 bits (114), Expect = 1e-05
Identities = 35/120 (29%), Positives = 53/120 (44%), Gaps = 2/120 (1%)
Query: 6 HRAARDGYLELLKEATRKELN--APDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AA G+LE++ N A TP AA HG + ++ G DP+ +
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK 123
G TPLHLA + L+ AN+ + TP +AA+KG+ ++ L A+
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
Score = 48.1 bits (113), Expect = 2e-05
Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 5/109 (4%)
Query: 26 NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLV 85
+A D+ G P AA G ++++ G + G TPLHLAA GHL + L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613
Query: 86 SFGANIWCLDNDYHTPLDMAAMKGHMECVRYL-----DSIAAKQSSLNP 129
AN+ L TPL +AA G V L D AA+QS P
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662
Score = 45.1 bits (105), Expect = 1e-04
Identities = 29/96 (30%), Positives = 43/96 (44%)
Query: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSF 83
+++ G TP L AA + L+++ G D ++ D G PLH AA NG
Sbjct: 387 DVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARL 446
Query: 84 LVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDS 119
L+ GA + + + TPL +AA R L S
Sbjct: 447 LLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/88 (30%), Positives = 43/88 (48%)
Query: 30 EDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGA 89
E+ +TP + G++E +RL+++ D D G TPL +AA + + L++ GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 90 NIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ +D D PL AA G R L
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLL 447
Score = 37.4 bits (85), Expect = 0.029
Identities = 31/115 (26%), Positives = 48/115 (41%), Gaps = 2/115 (1%)
Query: 6 HRAARDGYLELLKEATR--KELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI 63
H AAR G ++ + + NA ++ G TP A S+ ++ + +
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
Query: 64 WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLD 118
G TP HLAA G+ L LV GA + D TPL +A + +L+
Sbjct: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLE 745
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 63.2 bits (152), Expect = 5e-10
Identities = 39/116 (33%), Positives = 58/116 (50%), Gaps = 6/116 (5%)
Query: 6 HRAARDGYLELLKEATRKE----LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKC 61
H+ A G E+L ATR E +N DE+G TP +WAA HG + + ++ G DP
Sbjct: 154 HQLAAQG--EMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
Query: 62 DIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL 117
+ L LA S G+ + L+ G ++ D + TPL A H++CV+ L
Sbjct: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
Score = 30.4 bits (67), Expect = 3.5
Identities = 18/72 (25%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
Query: 8 AARDGYLELLKEATR--KELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG 65
A GY +++K ++N D +G TP L+A + +++ +++++ G DP G
Sbjct: 222 ACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSG 281
Query: 66 NTPLHLAASNGH 77
+ LA + G+
Sbjct: 282 YNSMDLAVALGY 293
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,283,779
Number of Sequences: 37866
Number of extensions: 850318
Number of successful extensions: 5063
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 321
Number of HSP's successfully gapped in prelim test: 64
Number of HSP's that attempted gapping in prelim test: 2856
Number of HSP's gapped (non-prelim): 1681
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.