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Search of human proteins with 33624861
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33624861 spectrin repeat containing, nuclear envelope 2
isoform 2 [Homo sapiens]
(429 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo... 851 0.0
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo... 847 0.0
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 814 0.0
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 809 0.0
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof... 309 4e-84
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 309 4e-84
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 309 4e-84
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 309 4e-84
gi|145580592 nesprin-3 [Homo sapiens] 77 3e-14
gi|33188443 microfilament and actin filament cross-linker protei... 53 6e-07
gi|33188445 microfilament and actin filament cross-linker protei... 53 6e-07
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 50 4e-06
gi|221316624 dystonin isoform 4 [Homo sapiens] 49 1e-05
gi|221316622 dystonin isoform 3 [Homo sapiens] 49 1e-05
gi|221316618 dystonin isoform 2 [Homo sapiens] 49 1e-05
gi|34577047 dystonin isoform 1 [Homo sapiens] 49 1e-05
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 49 1e-05
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 48 2e-05
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 48 2e-05
gi|67782321 spectrin beta isoform a [Homo sapiens] 46 6e-05
gi|67782319 spectrin beta isoform b [Homo sapiens] 46 6e-05
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 46 7e-05
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 45 2e-04
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 44 2e-04
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 44 2e-04
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 43 6e-04
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 42 8e-04
gi|24233517 IKK interacting protein isoform 1 [Homo sapiens] 42 8e-04
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 42 0.001
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 40 0.003
>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform
2 [Homo sapiens]
Length = 429
Score = 851 bits (2199), Expect = 0.0
Identities = 429/429 (100%), Positives = 429/429 (100%)
Query: 1 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60
MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS
Sbjct: 1 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60
Query: 61 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI
Sbjct: 61 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV
Sbjct: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD
Sbjct: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
Query: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ
Sbjct: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
Query: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES
Sbjct: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
Query: 361 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 420
RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
Sbjct: 361 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 420
Query: 421 RYTNGPPPT 429
RYTNGPPPT
Sbjct: 421 RYTNGPPPT 429
>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform
4 [Homo sapiens]
Length = 556
Score = 847 bits (2187), Expect = 0.0
Identities = 429/430 (99%), Positives = 429/430 (99%), Gaps = 1/430 (0%)
Query: 1 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60
MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS
Sbjct: 127 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 186
Query: 61 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI
Sbjct: 187 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 246
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV
Sbjct: 247 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 306
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD
Sbjct: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 366
Query: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ
Sbjct: 367 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 426
Query: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTEGEEETE 359
LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTEGEEETE
Sbjct: 427 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETE 486
Query: 360 SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 419
SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM
Sbjct: 487 SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 546
Query: 420 LRYTNGPPPT 429
LRYTNGPPPT
Sbjct: 547 LRYTNGPPPT 556
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 814 bits (2102), Expect = 0.0
Identities = 415/429 (96%), Positives = 415/429 (96%), Gaps = 14/429 (3%)
Query: 1 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60
MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS
Sbjct: 6493 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 6552
Query: 61 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI
Sbjct: 6553 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV
Sbjct: 6613 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6672
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
DSWRGGLRQSLMQCQ DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD
Sbjct: 6673 DSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 6718
Query: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ
Sbjct: 6719 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 6778
Query: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES
Sbjct: 6779 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 6838
Query: 361 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 420
RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
Sbjct: 6839 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 6898
Query: 421 RYTNGPPPT 429
RYTNGPPPT
Sbjct: 6899 RYTNGPPPT 6907
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)
Query: 53 AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 109
A I ++ + DRW+ + K+K+ +QQL+ ++S + TWL + E+EL
Sbjct: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
Query: 110 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 169
+ D QEI+ R+ Q++ + + + A V SV L + E +
Sbjct: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
Query: 170 SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 229
+ + + WR S+ + + R F D+ + WL SA+
Sbjct: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
Query: 230 QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 286
P + + EL + E +++ ER Q++++ + L + +
Sbjct: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 287 AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317
++ VH ++ L+ +V+ L L+ N
Sbjct: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
Score = 35.0 bits (79), Expect = 0.13
Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)
Query: 73 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 130
ELH + ++L N D +T WL+ ++ L K D+ I + E
Sbjct: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
Query: 131 LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 173
K D +L +V + L + ++ L++ L Q W
Sbjct: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
Score = 30.4 bits (67), Expect = 3.2
Identities = 49/211 (23%), Positives = 84/211 (39%), Gaps = 31/211 (14%)
Query: 78 LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK----PPSDI--------QEIELRVK 125
LK K + +N + LK E L L+ AK P +D+ QE L VK
Sbjct: 1302 LKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVK 1361
Query: 126 RLQ-EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWR 184
+ EI D K L + + F E + T ++ L S+ G
Sbjct: 1362 NKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGY----- 1416
Query: 185 GGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRAL 244
G+++ ++ + FK+ LL + +++ K + DP A+
Sbjct: 1417 -GVQEEF-----TEENKLLEACIFKN-----NELLKNIQDVQSQISKIGLKDPTVP--AV 1463
Query: 245 LECRRELMQLEKELVERQPQVDMLQEISNSL 275
++ L++L+K L E + + LQE++NSL
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSL 1494
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 809 bits (2090), Expect = 0.0
Identities = 415/430 (96%), Positives = 415/430 (96%), Gaps = 15/430 (3%)
Query: 1 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60
MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS
Sbjct: 6470 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 6529
Query: 61 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI
Sbjct: 6530 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV
Sbjct: 6590 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6649
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
DSWRGGLRQSLMQCQ DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD
Sbjct: 6650 DSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 6695
Query: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ
Sbjct: 6696 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 6755
Query: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTEGEEETE 359
LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTEGEEETE
Sbjct: 6756 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETE 6815
Query: 360 SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 419
SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM
Sbjct: 6816 SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 6875
Query: 420 LRYTNGPPPT 429
LRYTNGPPPT
Sbjct: 6876 LRYTNGPPPT 6885
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)
Query: 53 AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 109
A I ++ + DRW+ + K+K+ +QQL+ ++S + TWL + E+EL
Sbjct: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
Query: 110 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 169
+ D QEI+ R+ Q++ + + + A V SV L + E +
Sbjct: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
Query: 170 SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 229
+ + + WR S+ + + R F D+ + WL SA+
Sbjct: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
Query: 230 QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 286
P + + EL + E +++ ER Q++++ + L + +
Sbjct: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 287 AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317
++ VH ++ L+ +V+ L L+ N
Sbjct: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
Score = 35.0 bits (79), Expect = 0.13
Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)
Query: 73 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 130
ELH + ++L N D +T WL+ ++ L K D+ I + E
Sbjct: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
Query: 131 LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 173
K D +L +V + L + ++ L++ L Q W
Sbjct: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
Score = 30.4 bits (67), Expect = 3.2
Identities = 49/211 (23%), Positives = 84/211 (39%), Gaps = 31/211 (14%)
Query: 78 LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK----PPSDI--------QEIELRVK 125
LK K + +N + LK E L L+ AK P +D+ QE L VK
Sbjct: 1302 LKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVK 1361
Query: 126 RLQ-EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWR 184
+ EI D K L + + F E + T ++ L S+ G
Sbjct: 1362 NKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGY----- 1416
Query: 185 GGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRAL 244
G+++ ++ + FK+ LL + +++ K + DP A+
Sbjct: 1417 -GVQEEF-----TEENKLLEACIFKN-----NELLKNIQDVQSQISKIGLKDPTVP--AV 1463
Query: 245 LECRRELMQLEKELVERQPQVDMLQEISNSL 275
++ L++L+K L E + + LQE++NSL
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSL 1494
>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform
3 [Homo sapiens]
Length = 982
Score = 309 bits (791), Expect = 4e-84
Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)
Query: 5 RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58
R+ P P T YK G + L + + L ++E+ L G Q
Sbjct: 542 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 598
Query: 59 QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115
+G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL TE ELE L+ + +
Sbjct: 599 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 658
Query: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175
DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 659 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 718
Query: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
++ WRG L+ +LMQCQG FH++S LLL L + R+ +
Sbjct: 719 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 764
Query: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 765 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 824
Query: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337
+LK L ++VS+ + L+ +Q S S DE+D SG P +
Sbjct: 825 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 884
Query: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+
Sbjct: 885 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 944
Query: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428
LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 945 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 981
Score = 36.2 bits (82), Expect = 0.059
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 64 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 26 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 80
Query: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144
+EI+ ++ QE+ + + + V SV
Sbjct: 81 SEEIQRKLNEQQELQRDIEKHSTGVASV 108
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 309 bits (791), Expect = 4e-84
Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)
Query: 5 RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58
R+ P P T YK G + L + + L ++E+ L G Q
Sbjct: 2881 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 2937
Query: 59 QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115
+G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL TE ELE L+ + +
Sbjct: 2938 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 2997
Query: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175
DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 2998 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 3057
Query: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
++ WRG L+ +LMQCQG FH++S LLL L + R+ +
Sbjct: 3058 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 3103
Query: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 3104 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 3163
Query: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337
+LK L ++VS+ + L+ +Q S S DE+D SG P +
Sbjct: 3164 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 3223
Query: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+
Sbjct: 3224 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 3283
Query: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428
LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 3284 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 3320
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 28/340 (8%)
Query: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 87
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 433 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 492
Query: 88 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 147
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 493 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 547
Query: 148 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 206
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 548 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 607
Query: 207 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 266
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 608 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 662
Query: 267 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGTQNPAS 320
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ--- 719
Query: 321 PLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
++ +S AT P + RTT ++ S
Sbjct: 720 -----EKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 754
Score = 36.2 bits (82), Expect = 0.059
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 64 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 2442
Query: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144
+EI+ ++ QE+ + + + V SV
Sbjct: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASV 2470
Score = 32.3 bits (72), Expect = 0.85
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 70 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 126
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 136 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195
Query: 127 LQEILKAFDTYKALVVSVNV 146
Q +L ++ K V +V +
Sbjct: 196 RQHLLSEMESLKPKVQAVQL 215
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 309 bits (791), Expect = 4e-84
Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)
Query: 5 RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58
R+ P P T YK G + L + + L ++E+ L G Q
Sbjct: 8309 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 8365
Query: 59 QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115
+G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL TE ELE L+ + +
Sbjct: 8366 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 8425
Query: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175
DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 8426 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
Query: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
++ WRG L+ +LMQCQG FH++S LLL L + R+ +
Sbjct: 8486 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 8531
Query: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 8532 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 8591
Query: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337
+LK L ++VS+ + L+ +Q S S DE+D SG P +
Sbjct: 8592 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 8651
Query: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+
Sbjct: 8652 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 8711
Query: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428
LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 8712 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8748
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 28/340 (8%)
Query: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 87
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 5838 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5897
Query: 88 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 147
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 5898 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 5952
Query: 148 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 206
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 5953 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6012
Query: 207 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 266
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 6013 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6067
Query: 267 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGTQNPAS 320
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 6068 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ--- 6124
Query: 321 PLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
++ +S AT P + RTT ++ S
Sbjct: 6125 -----EKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6159
Score = 36.2 bits (82), Expect = 0.059
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 64 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 7793 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7847
Query: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144
+EI+ ++ QE+ + + + V SV
Sbjct: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASV 7875
Score = 32.7 bits (73), Expect = 0.65
Identities = 25/117 (21%), Positives = 53/117 (45%), Gaps = 6/117 (5%)
Query: 80 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 139
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 1451 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1505
Query: 140 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQ 195
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q
Sbjct: 1506 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQ 1562
Score = 32.3 bits (72), Expect = 0.85
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 70 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 126
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 5541 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 5600
Query: 127 LQEILKAFDTYKALVVSVNV 146
Q +L ++ K V +V +
Sbjct: 5601 RQHLLSEMESLKPKVQAVQL 5620
Score = 30.4 bits (67), Expect = 3.2
Identities = 47/220 (21%), Positives = 88/220 (40%), Gaps = 26/220 (11%)
Query: 100 KTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPES 159
K + E + + S QE E ++L+ LK+ ++ V + ++E L+ +
Sbjct: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
Query: 160 TELQS----------RLRQLS-----LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 204
LQ L L+ L +E A+ + SW+G L+ + T S
Sbjct: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
Query: 205 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 264
++ DF L WL RR KA ++ P L + + E+ +++ E Q
Sbjct: 4812 MVQSIDFQTEMSRSLDWL-----RRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
Query: 265 VDMLQEISNSLLIKGHGEDCIEAEEKVHV-IEKKLKQLRE 303
+ ++ +S+ E +A+E + +E L +L E
Sbjct: 4867 LRIMNALSHK-----EKEKFTKAKELISADLEHSLAELSE 4901
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 309 bits (791), Expect = 4e-84
Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)
Query: 5 RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58
R+ P P T YK G + L + + L ++E+ L G Q
Sbjct: 8357 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 8413
Query: 59 QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115
+G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL TE ELE L+ + +
Sbjct: 8414 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 8473
Query: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175
DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 8474 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8533
Query: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
++ WRG L+ +LMQCQG FH++S LLL L + R+ +
Sbjct: 8534 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 8579
Query: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 8580 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 8639
Query: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337
+LK L ++VS+ + L+ +Q S S DE+D SG P +
Sbjct: 8640 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 8699
Query: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+
Sbjct: 8700 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 8759
Query: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428
LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 8760 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 28/340 (8%)
Query: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 87
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 5909 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5968
Query: 88 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 147
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 5969 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 6023
Query: 148 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 206
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 6024 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6083
Query: 207 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 266
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 6084 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
Query: 267 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGTQNPAS 320
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ--- 6195
Query: 321 PLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
++ +S AT P + RTT ++ S
Sbjct: 6196 -----EKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6230
Score = 36.2 bits (82), Expect = 0.059
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 64 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7918
Query: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144
+EI+ ++ QE+ + + + V SV
Sbjct: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASV 7946
Score = 32.7 bits (73), Expect = 0.65
Identities = 25/117 (21%), Positives = 53/117 (45%), Gaps = 6/117 (5%)
Query: 80 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 139
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498
Query: 140 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQ 195
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q
Sbjct: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQ 1555
Score = 32.3 bits (72), Expect = 0.85
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 70 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 126
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 5612 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 5671
Query: 127 LQEILKAFDTYKALVVSVNV 146
Q +L ++ K V +V +
Sbjct: 5672 RQHLLSEMESLKPKVQAVQL 5691
Score = 30.4 bits (67), Expect = 3.2
Identities = 47/220 (21%), Positives = 88/220 (40%), Gaps = 26/220 (11%)
Query: 100 KTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPES 159
K + E + + S QE E ++L+ LK+ ++ V + ++E L+ +
Sbjct: 4763 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4822
Query: 160 TELQS----------RLRQLS-----LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 204
LQ L L+ L +E A+ + SW+G L+ + T S
Sbjct: 4823 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4882
Query: 205 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 264
++ DF L WL RR KA ++ P L + + E+ +++ E Q
Sbjct: 4883 MVQSIDFQTEMSRSLDWL-----RRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4937
Query: 265 VDMLQEISNSLLIKGHGEDCIEAEEKVHV-IEKKLKQLRE 303
+ ++ +S+ E +A+E + +E L +L E
Sbjct: 4938 LRIMNALSHK-----EKEKFTKAKELISADLEHSLAELSE 4972
>gi|145580592 nesprin-3 [Homo sapiens]
Length = 975
Score = 77.0 bits (188), Expect = 3e-14
Identities = 95/359 (26%), Positives = 147/359 (40%), Gaps = 33/359 (9%)
Query: 79 KIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 135
+ +Q++Q+ + + + W+ T +LE + P D + E +RL + F
Sbjct: 642 RCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERL---VAEFP 698
Query: 136 TYKALVVSVNVSSKEFLQTESPESTEL-QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQC 194
+A + V ++ SPE + Q LR+L+ W A + +S +R +Q
Sbjct: 699 EKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQ- 757
Query: 195 QGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 254
R +V K + N + + +P DP R L+Q
Sbjct: 758 -------RMEVDSGKK-----------MVFTNNIPKSGFLINPM-DPIPRHRRRANLLQE 798
Query: 255 EKELVERQPQV----DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLM 310
E+ E Q+ ++ NS L++ AE+ + + KL++L +V +
Sbjct: 799 EEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED-LRTRKSKLQELEARVPEGQH 857
Query: 311 ALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRVPGSTRPQR 370
+ + DE++ + + + E T + R
Sbjct: 858 LFENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKTRRWRGLG 917
Query: 371 SFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT 429
S R ALPLQLLLLL LLL LLP EED SCT ANNFARSF MLRY NGPPPT
Sbjct: 918 SLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRY-NGPPPT 975
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 52.8 bits (125), Expect = 6e-07
Identities = 61/272 (22%), Positives = 112/272 (41%), Gaps = 46/272 (16%)
Query: 66 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 121
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4804
Query: 122 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 180
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
+ L+ +L Q QG FH ++ LL L +++ + T
Sbjct: 4865 EEREQQLQSTLQQAQG--------------FHSEIEDFLLELTRMESQLSASKPTG---- 4906
Query: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH---------------GEDCI 285
L E RE + EL Q+ +E N LL KG +
Sbjct: 4907 --GLPETAREQLDTHMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4961
Query: 286 EAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317
E+K HV+ K+++ + ++ + L QN
Sbjct: 4962 LLEQKWHVVSSKMEERKSKLEEALNLATEFQN 4993
Score = 48.1 bits (113), Expect = 1e-05
Identities = 56/248 (22%), Positives = 102/248 (41%), Gaps = 22/248 (8%)
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 139
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Query: 140 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKT 199
L + S+ F + T LQ + L +EA SL+ +
Sbjct: 4275 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI-------------SLLNSERYAR 4318
Query: 200 RPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELV 259
R+ VL F + + L W+ + R A + P D L + + E+ QL + +
Sbjct: 4319 LERAQVLV-NQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIA 4375
Query: 260 ERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 319
E +P +D L +I L + + E+ EEK E Q++E+V Q +AL + +
Sbjct: 4376 EHKPHIDKLLKIGPQLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQS 4434
Query: 320 SPLPSFDE 327
+ + F +
Sbjct: 4435 TQITEFHD 4442
Score = 47.4 bits (111), Expect = 3e-05
Identities = 75/350 (21%), Positives = 142/350 (40%), Gaps = 35/350 (10%)
Query: 55 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 110
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 3858 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
Query: 111 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 168
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 3918 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3973
Query: 169 LSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR 228
L + Q L Q+L + LF +D +L WLA +++
Sbjct: 3974 LQARYSEIQDRCCRKAALLDQALSNAR----------LFGED----EVEVLNWLAEVEDK 4019
Query: 229 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 288
V D K D L + + L +E+V R+ VD + +LL + GE+ + +
Sbjct: 4020 LSSVFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ 4077
Query: 289 EKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRA 348
EK+ I+ + + S+ L L+ + A+ S E +G R
Sbjct: 4078 EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTG---------WLREVEEE 4128
Query: 349 VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 398
+ T+ G+ T ++P + Q+ V+ L L + + L L+P
Sbjct: 4129 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
Score = 42.7 bits (99), Expect = 6e-04
Identities = 44/211 (20%), Positives = 92/211 (43%), Gaps = 21/211 (9%)
Query: 73 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 132
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 2365
Query: 133 AFDTYKALVVSVNVSSKEFLQTESP-----ESTELQSRLRQLSLLWEAAQGAVDSWRGGL 187
++K + V +S ++ L E+ E +E+ + ++ L +A +
Sbjct: 2366 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK--LKDATE---------- 2413
Query: 188 RQSLMQCQGSKTRPRSDVLF--FKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 245
R + + + ++ ++L + F + +L W+ + + +K +DP L
Sbjct: 2414 RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ 2473
Query: 246 ECRRELMQLEKELVERQPQVDMLQEISNSLL 276
E QL++EL E Q V+ LQ+++ ++
Sbjct: 2474 EQLATTKQLQEELAEHQVPVEKLQKVARDIM 2504
Score = 33.9 bits (76), Expect = 0.29
Identities = 64/323 (19%), Positives = 126/323 (39%), Gaps = 38/323 (11%)
Query: 68 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 127
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3680
Query: 128 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA--QG 178
+ A + +AL V +N +F + + LQ +L+Q++ L +
Sbjct: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740
Query: 179 AVDSWRGGLRQSLMQCQG------SKTRPR-----SDVLFFKDFHQLSQNLLLWLASAKN 227
D GL + + K R +L F + LL WLA +
Sbjct: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEE 3800
Query: 228 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 287
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 3801 LI--ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858
Query: 288 EEKVHVIEKKLKQL------REQVSQDLMAL----QGTQNPASPLPSFDEVDSGDQPPAT 337
++ +E + +L R++ +D++ L T P S S E + P
Sbjct: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
Query: 338 SVPAPRAKFRAVRTTEGEEETES 360
+ A + + + +R EE+ E+
Sbjct: 3919 TQTA-KIQQQIIRHKALEEDIEN 3940
Score = 32.0 bits (71), Expect = 1.1
Identities = 40/209 (19%), Positives = 88/209 (42%), Gaps = 19/209 (9%)
Query: 115 SDIQEIELRVKRLQEILKAFDTYKA----LVVSVNVSSKEFLQTESPESTELQSRLRQLS 170
+++Q++ + K L+ LK T + V + +S + + + ++ E ++ Q S
Sbjct: 1835 AELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKS 1894
Query: 171 LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQ 230
L D+W L + KT+ + Q+L W+ + KN
Sbjct: 1895 L-----SSVSDTWNSRLLHFQNAVEIEKTKVLNQ---HTQLEGRLQDLRAWVGN-KNLIL 1945
Query: 231 KAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK 290
+ ++ + D +L C ++ L++ + ER+ Q+D L I H +D + +
Sbjct: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNR 2004
Query: 291 -----VHVIEKKLKQLREQVSQDLMALQG 314
++ +++ + + EQ + + ALQG
Sbjct: 2005 QMLRLLNELQRSFQDILEQTAAQVDALQG 2033
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 52.8 bits (125), Expect = 6e-07
Identities = 61/272 (22%), Positives = 112/272 (41%), Gaps = 46/272 (16%)
Query: 66 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 121
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4302
Query: 122 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 180
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
+ L+ +L Q QG FH ++ LL L +++ + T
Sbjct: 4363 EEREQQLQSTLQQAQG--------------FHSEIEDFLLELTRMESQLSASKPTG---- 4404
Query: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH---------------GEDCI 285
L E RE + EL Q+ +E N LL KG +
Sbjct: 4405 --GLPETAREQLDTHMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4459
Query: 286 EAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317
E+K HV+ K+++ + ++ + L QN
Sbjct: 4460 LLEQKWHVVSSKMEERKSKLEEALNLATEFQN 4491
Score = 48.1 bits (113), Expect = 1e-05
Identities = 56/248 (22%), Positives = 102/248 (41%), Gaps = 22/248 (8%)
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 139
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772
Query: 140 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKT 199
L + S+ F + T LQ + L +EA SL+ +
Sbjct: 3773 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI-------------SLLNSERYAR 3816
Query: 200 RPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELV 259
R+ VL F + + L W+ + R A + P D L + + E+ QL + +
Sbjct: 3817 LERAQVLV-NQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIA 3873
Query: 260 ERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 319
E +P +D L +I L + + E+ EEK E Q++E+V Q +AL + +
Sbjct: 3874 EHKPHIDKLLKIGPQLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQS 3932
Query: 320 SPLPSFDE 327
+ + F +
Sbjct: 3933 TQITEFHD 3940
Score = 47.4 bits (111), Expect = 3e-05
Identities = 75/350 (21%), Positives = 142/350 (40%), Gaps = 35/350 (10%)
Query: 55 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 110
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415
Query: 111 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 168
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3471
Query: 169 LSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR 228
L + Q L Q+L + LF +D +L WLA +++
Sbjct: 3472 LQARYSEIQDRCCRKAALLDQALSNAR----------LFGED----EVEVLNWLAEVEDK 3517
Query: 229 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 288
V D K D L + + L +E+V R+ VD + +LL + GE+ + +
Sbjct: 3518 LSSVFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ 3575
Query: 289 EKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRA 348
EK+ I+ + + S+ L L+ + A+ S E +G R
Sbjct: 3576 EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTG---------WLREVEEE 3626
Query: 349 VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 398
+ T+ G+ T ++P + Q+ V+ L L + + L L+P
Sbjct: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 3676
Score = 42.7 bits (99), Expect = 6e-04
Identities = 44/211 (20%), Positives = 92/211 (43%), Gaps = 21/211 (9%)
Query: 73 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 132
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 1806 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 1863
Query: 133 AFDTYKALVVSVNVSSKEFLQTESP-----ESTELQSRLRQLSLLWEAAQGAVDSWRGGL 187
++K + V +S ++ L E+ E +E+ + ++ L +A +
Sbjct: 1864 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK--LKDATE---------- 1911
Query: 188 RQSLMQCQGSKTRPRSDVLF--FKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 245
R + + + ++ ++L + F + +L W+ + + +K +DP L
Sbjct: 1912 RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ 1971
Query: 246 ECRRELMQLEKELVERQPQVDMLQEISNSLL 276
E QL++EL E Q V+ LQ+++ ++
Sbjct: 1972 EQLATTKQLQEELAEHQVPVEKLQKVARDIM 2002
Score = 33.9 bits (76), Expect = 0.29
Identities = 64/323 (19%), Positives = 126/323 (39%), Gaps = 38/323 (11%)
Query: 68 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 127
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 3124 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3178
Query: 128 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA--QG 178
+ A + +AL V +N +F + + LQ +L+Q++ L +
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3238
Query: 179 AVDSWRGGLRQSLMQCQG------SKTRPR-----SDVLFFKDFHQLSQNLLLWLASAKN 227
D GL + + K R +L F + LL WLA +
Sbjct: 3239 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEE 3298
Query: 228 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 287
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 3299 LI--ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3356
Query: 288 EEKVHVIEKKLKQL------REQVSQDLMAL----QGTQNPASPLPSFDEVDSGDQPPAT 337
++ +E + +L R++ +D++ L T P S S E + P
Sbjct: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
Query: 338 SVPAPRAKFRAVRTTEGEEETES 360
+ A + + + +R EE+ E+
Sbjct: 3417 TQTA-KIQQQIIRHKALEEDIEN 3438
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 50.1 bits (118), Expect = 4e-06
Identities = 60/255 (23%), Positives = 102/255 (40%), Gaps = 22/255 (8%)
Query: 38 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQ-ELHNK-LKIKQNLQQLNSDISAIT 95
PR+ + +Q G A + + + W+ + + EL K L+ QQ D +
Sbjct: 1542 PRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
Query: 96 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTE 155
W+ E EL M+ K ++ + VK+ Q + +A Y + + SS++ + E
Sbjct: 1602 AWMG--EQELHMMGQEKAKDELSA-QAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
Query: 156 SPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLS 215
PEST + R Q+ L+ + R L++ L CQ + D Q
Sbjct: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE--------LDDLEQWI 1710
Query: 216 QNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSL 275
Q + AS + + HVT + R E R+ + +E +VD ++N L
Sbjct: 1711 QEREVVAASHELGQDYEHVTMLRDKFR---EFSRDTSTIGQE------RVDSANALANGL 1761
Query: 276 LIKGHGEDCIEAEEK 290
+ GH AE K
Sbjct: 1762 IAGGHAARATVAEWK 1776
Score = 40.0 bits (92), Expect = 0.004
Identities = 46/243 (18%), Positives = 98/243 (40%), Gaps = 31/243 (12%)
Query: 66 WEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 123
+E +QA+ E L+ L + S+ A W+++ E L L + P ++++E+
Sbjct: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLAL---PERLEDLEVV 890
Query: 124 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 183
+R + + +T A + +VN +++ L+ P + + QL+ W+ + D
Sbjct: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
Query: 184 RGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA---- 239
+ L + L +++H W+ R+K V +
Sbjct: 951 KAAL---------------TSALSIQNYHLECTETQAWM------REKTKVIESTQGLGN 989
Query: 240 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 299
D +L +R+L E++L +V L +N+ L GH + ++ ++ +
Sbjct: 990 DLAGVLALQRKLAGTERDLEAIAARVGELTREANA-LAAGHPAQAVAINARLREVQTGWE 1048
Query: 300 QLR 302
LR
Sbjct: 1049 DLR 1051
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 64 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4736 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4793
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4794 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4853
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 239
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4854 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4899
Query: 240 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 299
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4900 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956
Query: 300 QL 301
++
Sbjct: 4957 EV 4958
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 73 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 128
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1853 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1910
Query: 129 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 188
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1911 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1969
Query: 189 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 247
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1970 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 2028
Query: 248 RRELMQLEKELVERQPQVDMLQEISNSLL 276
E L+ ++ +Q V+ L++ + LL
Sbjct: 2029 LEETKALQGQISSQQVAVEKLKKTAEVLL 2057
Score = 39.7 bits (91), Expect = 0.005
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 35 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 81
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2399 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2456
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 141
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2457 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2515
Query: 142 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 198
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2516 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2570
Query: 199 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 257
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2571 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2617
Query: 258 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 306
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2618 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2668
Score = 34.7 bits (78), Expect = 0.17
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 48 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 103
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2641 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2700
Query: 104 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 157
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2701 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2759
Query: 158 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 217
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2760 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2800
Query: 218 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 277
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2801 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2858
Query: 278 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 307
K G + + +++ I+ +QV +
Sbjct: 2859 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2888
Score = 34.3 bits (77), Expect = 0.22
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 72 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 131
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2782 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2836
Query: 132 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2837 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2895
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
SL + K + + L W+ +N ++ DP
Sbjct: 2896 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2938
Query: 250 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 309
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2939 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 2997
Query: 310 MALQGTQNPASPLPSFDEV 328
L +N F EV
Sbjct: 2998 FCL---ENMTQKFKEFQEV 3013
Score = 29.6 bits (65), Expect = 5.5
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 80 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 136
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 623 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 679
Query: 137 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 196
+++ + +S +Q +P +L +L + L+
Sbjct: 680 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 721
Query: 197 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 255
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 722 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 774
Query: 256 KELVERQPQVDMLQEISNSLLIKGH 280
+EL +++ + +QEI+ LL++ H
Sbjct: 775 RELDQKEENIKSVQEIAEQLLLENH 799
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 64 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4747 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4804
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4805 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4864
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 239
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4865 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4910
Query: 240 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 299
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4911 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
Query: 300 QL 301
++
Sbjct: 4968 EV 4969
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 73 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 128
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1864 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1921
Query: 129 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 188
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1922 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1980
Query: 189 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 247
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1981 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 2039
Query: 248 RRELMQLEKELVERQPQVDMLQEISNSLL 276
E L+ ++ +Q V+ L++ + LL
Sbjct: 2040 LEETKALQGQISSQQVAVEKLKKTAEVLL 2068
Score = 39.7 bits (91), Expect = 0.005
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 35 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 81
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2410 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2467
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 141
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2468 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2526
Query: 142 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 198
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2527 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2581
Query: 199 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 257
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2582 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2628
Query: 258 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 306
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2629 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2679
Score = 34.7 bits (78), Expect = 0.17
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 48 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 103
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2711
Query: 104 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 157
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2712 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2770
Query: 158 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 217
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2771 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2811
Query: 218 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 277
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2812 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2869
Query: 278 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 307
K G + + +++ I+ +QV +
Sbjct: 2870 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2899
Score = 34.3 bits (77), Expect = 0.22
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 72 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 131
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2793 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2847
Query: 132 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2848 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2906
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
SL + K + + L W+ +N ++ DP
Sbjct: 2907 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2949
Query: 250 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 309
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2950 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 3008
Query: 310 MALQGTQNPASPLPSFDEV 328
L +N F EV
Sbjct: 3009 FCL---ENMTQKFKEFQEV 3024
Score = 29.6 bits (65), Expect = 5.5
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 80 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 136
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 634 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 690
Query: 137 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 196
+++ + +S +Q +P +L +L + L+
Sbjct: 691 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 732
Query: 197 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 255
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 733 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 785
Query: 256 KELVERQPQVDMLQEISNSLLIKGH 280
+EL +++ + +QEI+ LL++ H
Sbjct: 786 RELDQKEENIKSVQEIAEQLLLENH 810
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 64 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4885 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4942
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4943 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 5002
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 239
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 5003 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 5048
Query: 240 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 299
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 5049 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105
Query: 300 QL 301
++
Sbjct: 5106 EV 5107
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 73 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 128
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 2002 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 2059
Query: 129 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 188
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 2060 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 2118
Query: 189 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 247
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 2119 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 2177
Query: 248 RRELMQLEKELVERQPQVDMLQEISNSLL 276
E L+ ++ +Q V+ L++ + LL
Sbjct: 2178 LEETKALQGQISSQQVAVEKLKKTAEVLL 2206
Score = 39.7 bits (91), Expect = 0.005
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 35 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 81
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2548 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2605
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 141
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2606 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2664
Query: 142 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 198
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2665 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2719
Query: 199 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 257
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2720 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2766
Query: 258 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 306
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2767 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2817
Score = 34.7 bits (78), Expect = 0.17
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 48 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 103
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2790 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2849
Query: 104 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 157
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2850 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2908
Query: 158 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 217
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2909 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2949
Query: 218 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 277
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2950 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 3007
Query: 278 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 307
K G + + +++ I+ +QV +
Sbjct: 3008 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 3037
Score = 34.3 bits (77), Expect = 0.22
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 72 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 131
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2931 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2985
Query: 132 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2986 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 3044
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
SL + K + + L W+ +N ++ DP
Sbjct: 3045 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 3087
Query: 250 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 309
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 3088 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 3146
Query: 310 MALQGTQNPASPLPSFDEV 328
L +N F EV
Sbjct: 3147 FCL---ENMTQKFKEFQEV 3162
Score = 29.6 bits (65), Expect = 5.5
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 80 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 136
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 772 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 828
Query: 137 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 196
+++ + +S +Q +P +L +L + L+
Sbjct: 829 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 870
Query: 197 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 255
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 871 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 923
Query: 256 KELVERQPQVDMLQEISNSLLIKGH 280
+EL +++ + +QEI+ LL++ H
Sbjct: 924 RELDQKEENIKSVQEIAEQLLLENH 948
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 64 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4707 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4764
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4765 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4824
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 239
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4825 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4870
Query: 240 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 299
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4871 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
Query: 300 QL 301
++
Sbjct: 4928 EV 4929
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 73 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 128
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1824 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1881
Query: 129 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 188
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1882 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1940
Query: 189 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 247
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1941 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 1999
Query: 248 RRELMQLEKELVERQPQVDMLQEISNSLL 276
E L+ ++ +Q V+ L++ + LL
Sbjct: 2000 LEETKALQGQISSQQVAVEKLKKTAEVLL 2028
Score = 39.7 bits (91), Expect = 0.005
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 35 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 81
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2370 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2427
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 141
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2428 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2486
Query: 142 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 198
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2487 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2541
Query: 199 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 257
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2542 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2588
Query: 258 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 306
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2589 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2639
Score = 34.7 bits (78), Expect = 0.17
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 48 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 103
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2671
Query: 104 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 157
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2672 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2730
Query: 158 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 217
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2731 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2771
Query: 218 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 277
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2772 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2829
Query: 278 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 307
K G + + +++ I+ +QV +
Sbjct: 2830 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2859
Score = 34.3 bits (77), Expect = 0.22
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 72 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 131
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2753 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2807
Query: 132 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2808 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2866
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
SL + K + + L W+ +N ++ DP
Sbjct: 2867 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2909
Query: 250 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 309
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2910 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 2968
Query: 310 MALQGTQNPASPLPSFDEV 328
L +N F EV
Sbjct: 2969 FCL---ENMTQKFKEFQEV 2984
Score = 29.6 bits (65), Expect = 5.5
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 80 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 136
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 594 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 650
Query: 137 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 196
+++ + +S +Q +P +L +L + L+
Sbjct: 651 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 692
Query: 197 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 255
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 693 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 745
Query: 256 KELVERQPQVDMLQEISNSLLIKGH 280
+EL +++ + +QEI+ LL++ H
Sbjct: 746 RELDQKEENIKSVQEIAEQLLLENH 770
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 64 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4381 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4438
Query: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4439 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4498
Query: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 239
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4499 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4544
Query: 240 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 299
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4545 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601
Query: 300 QL 301
++
Sbjct: 4602 EV 4603
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 73 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 128
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1498 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1555
Query: 129 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 188
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1556 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1614
Query: 189 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 247
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1615 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 1673
Query: 248 RRELMQLEKELVERQPQVDMLQEISNSLL 276
E L+ ++ +Q V+ L++ + LL
Sbjct: 1674 LEETKALQGQISSQQVAVEKLKKTAEVLL 1702
Score = 39.7 bits (91), Expect = 0.005
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 35 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 81
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2044 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2101
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 141
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2102 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2160
Query: 142 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 198
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2161 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2215
Query: 199 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 257
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2216 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2262
Query: 258 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 306
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2263 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2313
Score = 34.7 bits (78), Expect = 0.17
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 48 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 103
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2286 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2345
Query: 104 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 157
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2346 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2404
Query: 158 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 217
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2405 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2445
Query: 218 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 277
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2446 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2503
Query: 278 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 307
K G + + +++ I+ +QV +
Sbjct: 2504 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2533
Score = 34.3 bits (77), Expect = 0.22
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 72 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 131
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2427 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2481
Query: 132 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2482 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2540
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
SL + K + + L W+ +N ++ DP
Sbjct: 2541 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2583
Query: 250 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 309
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2584 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 2642
Query: 310 MALQGTQNPASPLPSFDEV 328
L +N F EV
Sbjct: 2643 FCL---ENMTQKFKEFQEV 2658
Score = 29.6 bits (65), Expect = 5.5
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 80 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 136
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 268 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 324
Query: 137 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 196
+++ + +S +Q +P +L +L + L+
Sbjct: 325 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 366
Query: 197 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 255
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 367 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 419
Query: 256 KELVERQPQVDMLQEISNSLLIKGH 280
+EL +++ + +QEI+ LL++ H
Sbjct: 420 RELDQKEENIKSVQEIAEQLLLENH 444
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 47.8 bits (112), Expect = 2e-05
Identities = 51/217 (23%), Positives = 90/217 (41%), Gaps = 23/217 (10%)
Query: 66 WEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 123
WE I+ A E H +L LQ+ +D +T+W+ + +A + ++A SD+ E
Sbjct: 343 WEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA---SDVAGAEAL 399
Query: 124 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 183
+ R QE D ++ S + S + L S E++ +L LS E ++ W
Sbjct: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLS---EERAALLELW 456
Query: 184 RGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRA 243
RQ QC + LF++D Q+ W++ + + D A
Sbjct: 457 E-LRRQQYEQCMDLQ-------LFYRDTEQVDN----WMSKQEAFLLNEDLGDSLDSVEA 504
Query: 244 LLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 280
LL+ + EK L ++ ++ L E + L+ H
Sbjct: 505 LLKKHED---FEKSLSAQEEKITALDEFATKLIQNNH 538
Score = 43.5 bits (101), Expect = 4e-04
Identities = 55/300 (18%), Positives = 127/300 (42%), Gaps = 32/300 (10%)
Query: 35 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWE-MIQAQELHN-KLKIKQNLQQLNSDIS 92
K G ++++ N +D A + E W+ +++A EL KL+ QQ N ++
Sbjct: 633 KAGQKLIDVNHYAKDEVAARMNE----VISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 93 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 152
I WL + E L K +++Q ++ + L+ + A ++ + + + +++F
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA---HQDRIDGITIQARQFQ 745
Query: 153 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 212
++ ++ + L +EA + + + + L SL Q F+D
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ-----------LFRDV- 793
Query: 213 QLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEIS 272
++ W+ + + A T+ D + ++ L+ E+ +P++ + +
Sbjct: 794 ---EDEETWI---REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
Query: 273 NSLLIKGH--GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDS 330
N+++ +GH ED + K+H + +K + L+ + SQ L+ + +E +S
Sbjct: 848 NAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Score = 38.5 bits (88), Expect = 0.012
Identities = 25/125 (20%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 65 RWEMI--QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 122
+WE++ + +E KL Q L Q + + W+ EA + ++ + D++ +E+
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQ---DLEHVEV 186
Query: 123 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 182
K+ +E ++ V VN + + +Q + PE ++++ +++ W+ +G
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQ 246
Query: 183 WRGGL 187
+G L
Sbjct: 247 RQGKL 251
Score = 37.4 bits (85), Expect = 0.026
Identities = 53/257 (20%), Positives = 96/257 (37%), Gaps = 32/257 (12%)
Query: 66 WEMIQAQELHNKLKI--KQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 123
W+ ++ L + K+ +Q+ N D+ +W+K+ E + + + +Q + +
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 124 VKRLQEILKAF-DTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 182
+ L+ L A D KAL + Q+ +T++Q + +L WE +
Sbjct: 297 HEGLERDLAALEDKVKALCAEAD----RLQQSHPLSATQIQVKREELITNWEQIRTLAAE 352
Query: 183 WRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 242
L S + F DF L+ W+ K + A
Sbjct: 353 RHARLNDSYRLQR-----------FLADFRDLTS----WVTEMKALINADELASDVAGAE 397
Query: 243 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEK------ 296
ALL+ +E + E+ + E +LL GH E EK+ V+ +
Sbjct: 398 ALLDRHQE---HKGEIDAHEDSFKSADESGQALLAAGHYAS-DEVREKLTVLSEERAALL 453
Query: 297 KLKQLREQVSQDLMALQ 313
+L +LR Q + M LQ
Sbjct: 454 ELWELRRQQYEQCMDLQ 470
Score = 36.2 bits (82), Expect = 0.059
Identities = 45/251 (17%), Positives = 93/251 (37%), Gaps = 24/251 (9%)
Query: 64 DRWEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 121
+RW +Q A+E L +Q+ + D W+++ L + +Q ++
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQ 1272
Query: 122 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVD 181
+ + + L A V S+ +++ +Q+ + +LQ + +L+ W + D
Sbjct: 1273 RKHEGFERDLAALGDK---VNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
Query: 182 SWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADP 241
+ L S F DF ++L+ W+ + +
Sbjct: 1330 QRKAKLGDS-----------HDLQRFLSDF----RDLMSWINGIRGLVSSDELAKDVTGA 1374
Query: 242 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 301
ALLE +E E+ R ++ LL GH E ++K+ +++++ L
Sbjct: 1375 EALLERHQE---HRTEIDARAGTFQAFEQFGQQLLAHGHYAS-PEIKQKLDILDQERADL 1430
Query: 302 REQVSQDLMAL 312
+ Q M L
Sbjct: 1431 EKAWVQRRMML 1441
Score = 35.8 bits (81), Expect = 0.077
Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 3/66 (4%)
Query: 55 ITEQQSGAFDRWEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK 112
I+ +++ DRW ++AQ E +KL Q LQQ + D+ I W+ + + + + K
Sbjct: 1522 ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYK 1580
Query: 113 PPSDIQ 118
P++IQ
Sbjct: 1581 DPTNIQ 1586
Score = 35.0 bits (79), Expect = 0.13
Identities = 44/239 (18%), Positives = 92/239 (38%), Gaps = 27/239 (11%)
Query: 43 GNPQQEDGGLAG----ITEQQSGAFDRWEMI--QAQELHNKLKIKQNLQQLNSDISAITT 96
GN E G AG + + + D+W+ + ++ E KLK Q N+ I
Sbjct: 1613 GNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDF 1672
Query: 97 WLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES 156
WL + EA L K D+ + +K+ Q + ++ + +N + + + +
Sbjct: 1673 WLSEVEALLASEDYGK---DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSA 1729
Query: 157 PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQ 216
++++++ + ++ ++ + S R L +S Q FF+D
Sbjct: 1730 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ-----------FFRDMDDEES 1778
Query: 217 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSL 275
W+ K ++ D D + R++ +LE EL +P + + + L
Sbjct: 1779 ----WI---KEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKL 1830
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 47.8 bits (112), Expect = 2e-05
Identities = 51/217 (23%), Positives = 90/217 (41%), Gaps = 23/217 (10%)
Query: 66 WEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 123
WE I+ A E H +L LQ+ +D +T+W+ + +A + ++A SD+ E
Sbjct: 343 WEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA---SDVAGAEAL 399
Query: 124 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 183
+ R QE D ++ S + S + L S E++ +L LS E ++ W
Sbjct: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLS---EERAALLELW 456
Query: 184 RGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRA 243
RQ QC + LF++D Q+ W++ + + D A
Sbjct: 457 E-LRRQQYEQCMDLQ-------LFYRDTEQVDN----WMSKQEAFLLNEDLGDSLDSVEA 504
Query: 244 LLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 280
LL+ + EK L ++ ++ L E + L+ H
Sbjct: 505 LLKKHED---FEKSLSAQEEKITALDEFATKLIQNNH 538
Score = 43.5 bits (101), Expect = 4e-04
Identities = 55/300 (18%), Positives = 127/300 (42%), Gaps = 32/300 (10%)
Query: 35 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWE-MIQAQELHN-KLKIKQNLQQLNSDIS 92
K G ++++ N +D A + E W+ +++A EL KL+ QQ N ++
Sbjct: 633 KAGQKLIDVNHYAKDEVAARMNE----VISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 93 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 152
I WL + E L K +++Q ++ + L+ + A ++ + + + +++F
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA---HQDRIDGITIQARQFQ 745
Query: 153 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 212
++ ++ + L +EA + + + + L SL Q F+D
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ-----------LFRDV- 793
Query: 213 QLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEIS 272
++ W+ + + A T+ D + ++ L+ E+ +P++ + +
Sbjct: 794 ---EDEETWI---REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
Query: 273 NSLLIKGH--GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDS 330
N+++ +GH ED + K+H + +K + L+ + SQ L+ + +E +S
Sbjct: 848 NAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Score = 38.5 bits (88), Expect = 0.012
Identities = 25/125 (20%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 65 RWEMI--QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 122
+WE++ + +E KL Q L Q + + W+ EA + ++ + D++ +E+
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQ---DLEHVEV 186
Query: 123 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 182
K+ +E ++ V VN + + +Q + PE ++++ +++ W+ +G
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQ 246
Query: 183 WRGGL 187
+G L
Sbjct: 247 RQGKL 251
Score = 37.4 bits (85), Expect = 0.026
Identities = 53/257 (20%), Positives = 96/257 (37%), Gaps = 32/257 (12%)
Query: 66 WEMIQAQELHNKLKI--KQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 123
W+ ++ L + K+ +Q+ N D+ +W+K+ E + + + +Q + +
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 124 VKRLQEILKAF-DTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 182
+ L+ L A D KAL + Q+ +T++Q + +L WE +
Sbjct: 297 HEGLERDLAALEDKVKALCAEAD----RLQQSHPLSATQIQVKREELITNWEQIRTLAAE 352
Query: 183 WRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 242
L S + F DF L+ W+ K + A
Sbjct: 353 RHARLNDSYRLQR-----------FLADFRDLTS----WVTEMKALINADELASDVAGAE 397
Query: 243 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEK------ 296
ALL+ +E + E+ + E +LL GH E EK+ V+ +
Sbjct: 398 ALLDRHQE---HKGEIDAHEDSFKSADESGQALLAAGHYAS-DEVREKLTVLSEERAALL 453
Query: 297 KLKQLREQVSQDLMALQ 313
+L +LR Q + M LQ
Sbjct: 454 ELWELRRQQYEQCMDLQ 470
Score = 36.2 bits (82), Expect = 0.059
Identities = 45/251 (17%), Positives = 93/251 (37%), Gaps = 24/251 (9%)
Query: 64 DRWEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 121
+RW +Q A+E L +Q+ + D W+++ L + +Q ++
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQ 1272
Query: 122 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVD 181
+ + + L A V S+ +++ +Q+ + +LQ + +L+ W + D
Sbjct: 1273 RKHEGFERDLAALGDK---VNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
Query: 182 SWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADP 241
+ L S F DF ++L+ W+ + +
Sbjct: 1330 QRKAKLGDS-----------HDLQRFLSDF----RDLMSWINGIRGLVSSDELAKDVTGA 1374
Query: 242 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 301
ALLE +E E+ R ++ LL GH E ++K+ +++++ L
Sbjct: 1375 EALLERHQE---HRTEIDARAGTFQAFEQFGQQLLAHGHYAS-PEIKQKLDILDQERADL 1430
Query: 302 REQVSQDLMAL 312
+ Q M L
Sbjct: 1431 EKAWVQRRMML 1441
Score = 36.2 bits (82), Expect = 0.059
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 55 ITEQQSGAFDRWEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK 112
I+ +++ DRW ++AQ E +KL Q LQQ + D+ I W+ + + + + K
Sbjct: 1522 ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYK 1580
Query: 113 PPSDIQEIELRVK 125
P++IQ +L K
Sbjct: 1581 DPTNIQLSKLLSK 1593
Score = 35.0 bits (79), Expect = 0.13
Identities = 44/239 (18%), Positives = 92/239 (38%), Gaps = 27/239 (11%)
Query: 43 GNPQQEDGGLAG----ITEQQSGAFDRWEMI--QAQELHNKLKIKQNLQQLNSDISAITT 96
GN E G AG + + + D+W+ + ++ E KLK Q N+ I
Sbjct: 1618 GNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDF 1677
Query: 97 WLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES 156
WL + EA L K D+ + +K+ Q + ++ + +N + + + +
Sbjct: 1678 WLSEVEALLASEDYGK---DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSA 1734
Query: 157 PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQ 216
++++++ + ++ ++ + S R L +S Q FF+D
Sbjct: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ-----------FFRDMDDEES 1783
Query: 217 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSL 275
W+ K ++ D D + R++ +LE EL +P + + + L
Sbjct: 1784 ----WI---KEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKL 1835
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 46.2 bits (108), Expect = 6e-05
Identities = 51/256 (19%), Positives = 104/256 (40%), Gaps = 25/256 (9%)
Query: 70 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 129
QA +L+ +L + + A W+ + E L ++M D++ ++ R L +
Sbjct: 836 QADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQ 895
Query: 130 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
+K T + VN+++ +++ P S E++ L+ W+A Q V R +
Sbjct: 896 EMKTLMTQ---IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
+L + D + S+ W+ + D D ++ +R
Sbjct: 953 ALRVHN-----------YCVDCEETSK----WITD--KTKVVESTKDLGRDLAGIIAIQR 995
Query: 250 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 309
+L LE+++ Q +VD L+ S L+ + E +E + +K L++L + + Q L
Sbjct: 996 KLSGLERDVAAIQARVDALERESQQLM-----DSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
Query: 310 MALQGTQNPASPLPSF 325
+ S L +F
Sbjct: 1051 QGQEDLLGEVSQLQAF 1066
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 46.2 bits (108), Expect = 6e-05
Identities = 51/256 (19%), Positives = 104/256 (40%), Gaps = 25/256 (9%)
Query: 70 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 129
QA +L+ +L + + A W+ + E L ++M D++ ++ R L +
Sbjct: 836 QADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQ 895
Query: 130 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
+K T + VN+++ +++ P S E++ L+ W+A Q V R +
Sbjct: 896 EMKTLMTQ---IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
+L + D + S+ W+ + D D ++ +R
Sbjct: 953 ALRVHN-----------YCVDCEETSK----WITD--KTKVVESTKDLGRDLAGIIAIQR 995
Query: 250 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 309
+L LE+++ Q +VD L+ S L+ + E +E + +K L++L + + Q L
Sbjct: 996 KLSGLERDVAAIQARVDALERESQQLM-----DSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
Query: 310 MALQGTQNPASPLPSF 325
+ S L +F
Sbjct: 1051 QGQEDLLGEVSQLQAF 1066
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 45.8 bits (107), Expect = 7e-05
Identities = 67/318 (21%), Positives = 137/318 (43%), Gaps = 46/318 (14%)
Query: 82 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 141
Q ++Q N ++A + EL+ L+ + + ++ +EL + R +E L D YKA +
Sbjct: 292 QKVKQENIQLAADARSARAYRDELDSLR--EKANRVERLELELTRCKEKLHDVDFYKARM 349
Query: 142 VSVN------VSSKEFLQTE--------------SPESTELQSRLRQLSLLWEAAQGAVD 181
+ + +K L+ + E+ +L+S+L L L + + ++
Sbjct: 350 EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE 409
Query: 182 SWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADP 241
L ++++ K + QLS+N A + +K+ V +
Sbjct: 410 EL---LEENMVLEIAQKQSMNESAHLGWELEQLSKN-----ADLSDASRKSFVFE----- 456
Query: 242 RALLEC-RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
L EC +++LEKE Q + L++ SL+++ G C E E++ H + KK+++
Sbjct: 457 --LNECASSRILKLEKENQSLQSTIQGLRDA--SLVLEESGLKCGELEKENHQLSKKIEK 512
Query: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
L+ Q+ ++ + Q + + L + +Q + K R ++ E E++ +
Sbjct: 513 LQTQLEREKQSNQDLETLSEEL-----IREKEQLQSDMETLKADKARQIKDLEQEKDHLN 567
Query: 361 RVPGSTRPQRSFLSRVVR 378
R S R +RS +S R
Sbjct: 568 RAMWSLR-ERSQVSSEAR 584
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 44.7 bits (104), Expect = 2e-04
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 33/243 (13%)
Query: 69 IQAQELHNK-LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQ-EIELRVKR 126
I +EL K K+++ LQ + S+ S I +K+ + +LE K+ P +Q E + K
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 127 LQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLS--LLWEAAQGAVDSWR 184
LQ +VS+K Q E EL +RL Q +W + + W
Sbjct: 274 LQ----------------SVSAKLQAQVEE---NELWNRLNQQQEEKMWRQEE-KIQEW- 312
Query: 185 GGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRAL 244
+ +Q Q K R + + + ++ Q ++W K RRQ+ + + + R L
Sbjct: 313 ----EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRL 368
Query: 245 LECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQ 304
E E + +EL E+ + + ++E K E+ I +EK E K+ + E+
Sbjct: 369 EEMMWEKEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQEEK 424
Query: 305 VSQ 307
+ +
Sbjct: 425 IRE 427
Score = 29.6 bits (65), Expect = 5.5
Identities = 45/265 (16%), Positives = 106/265 (40%), Gaps = 35/265 (13%)
Query: 57 EQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD 116
E QS + ++ EL N+L +Q + + I W +K + + E K+ +
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE-EKIQEWEEKIQEQEE--KIREQEEK 329
Query: 117 IQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLS-LLWEA 175
I+E E +++R +E++ +E ++ + E + ++R+L ++WE
Sbjct: 330 IREQEEKMRRQEEMMW--------------EKEEKMRRQEEMMWEKEEKMRRLEEMMWEK 375
Query: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
+ + Q ++ Q K + + + + Q +W K R Q+ +
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEKIR--EQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 236 DP---------------KADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 280
+ K + + E+ + E+++ E++ +++ I+
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 281 GEDCIEAEEKVHVIEKKLKQLREQV 305
E EEK+H E+K+++ E++
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKM 518
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 44.3 bits (103), Expect = 2e-04
Identities = 49/247 (19%), Positives = 108/247 (43%), Gaps = 34/247 (13%)
Query: 35 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 92
KEG ++++ P+ E A + E+ +G WE++++ Q +L + +
Sbjct: 1322 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1377
Query: 93 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 152
+ WL E++++ K D+ + + +K+ Q + + +
Sbjct: 1378 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQML------------------ENQM 1416
Query: 153 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 212
+ E ELQS+ + LS ++ VDS R ++ M+ + ++L K+ H
Sbjct: 1417 EVRKKEIEELQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH 1475
Query: 213 QLSQNL---LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQ 269
Q ++++ +LW+ R A TD + + + ++ L+KE+ QP++D +
Sbjct: 1476 QFNRDVEDEILWVGE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1532
Query: 270 EISNSLL 276
E S +++
Sbjct: 1533 ERSQNIV 1539
Score = 37.4 bits (85), Expect = 0.026
Identities = 45/223 (20%), Positives = 87/223 (39%), Gaps = 24/223 (10%)
Query: 70 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 129
+ ++ H +L+ QQ D + W+ +E EL M+ K + + + +K+ Q
Sbjct: 1567 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1623
Query: 130 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 187
+ +A + Y V ++ +S+ + PES + R ++ L+ + + RG L
Sbjct: 1624 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1683
Query: 188 RQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 247
R L Q ++ L Q W+A + + L E
Sbjct: 1684 RHRLFQLN-------------REVDDLEQ----WIAEREVVAGSHELGQDYEHVTMLQER 1726
Query: 248 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK 290
RE + + Q +VD + +++ L+ GH + AE K
Sbjct: 1727 FREFARDTGNI--GQERVDTVNHLADELINSGHSDAATIAEWK 1767
Score = 32.0 bits (71), Expect = 1.1
Identities = 44/239 (18%), Positives = 91/239 (38%), Gaps = 28/239 (11%)
Query: 71 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--Q 128
A EL +LK ++LQ+ D ++ W+ E + A+ S + L K L Q
Sbjct: 1251 ASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQ 1304
Query: 129 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 188
+ + K + + + + + ++ +L L +WE +
Sbjct: 1305 AFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ------- 1357
Query: 189 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECR 248
+K + D + F Q +L WL +++ Q LL
Sbjct: 1358 --------TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL--- 1406
Query: 249 RELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 307
++ LE ++ R+ +++ LQ + +L +G D E + K ++ K +L E +++
Sbjct: 1407 KKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTD--EVDSKRLTVQTKFMELLEPLNE 1463
Score = 30.8 bits (68), Expect = 2.5
Identities = 56/294 (19%), Positives = 118/294 (40%), Gaps = 37/294 (12%)
Query: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 88
+D KE ++ + +P Q L+ + E D WE ++ + + + + LQQ
Sbjct: 1000 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1055
Query: 89 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 148
D+ +WL +T+ + M P+ + E E + + + I D Y+ +
Sbjct: 1056 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1112
Query: 149 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLF 207
+ Q ++ + L+ RL+ L W ++ + L QS Q + +++
Sbjct: 1113 EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL 1172
Query: 208 FKDFHQLSQNLL---LWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 264
+ L+ + L A A ++Q+ +T A+ + +
Sbjct: 1173 NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDAN---------------------EEK 1211
Query: 265 VDMLQEISNSLLIKGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317
++ + E L+ G+ D I +EKV I+ + ++ RE S+ LM L+ ++
Sbjct: 1212 INAVVETGRRLVSDGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1263
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 44.3 bits (103), Expect = 2e-04
Identities = 49/247 (19%), Positives = 108/247 (43%), Gaps = 34/247 (13%)
Query: 35 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 92
KEG ++++ P+ E A + E+ +G WE++++ Q +L + +
Sbjct: 1335 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
Query: 93 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 152
+ WL E++++ K D+ + + +K+ Q + + +
Sbjct: 1391 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQML------------------ENQM 1429
Query: 153 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 212
+ E ELQS+ + LS ++ VDS R ++ M+ + ++L K+ H
Sbjct: 1430 EVRKKEIEELQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH 1488
Query: 213 QLSQNL---LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQ 269
Q ++++ +LW+ R A TD + + + ++ L+KE+ QP++D +
Sbjct: 1489 QFNRDVEDEILWVGE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545
Query: 270 EISNSLL 276
E S +++
Sbjct: 1546 ERSQNIV 1552
Score = 37.4 bits (85), Expect = 0.026
Identities = 45/223 (20%), Positives = 87/223 (39%), Gaps = 24/223 (10%)
Query: 70 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 129
+ ++ H +L+ QQ D + W+ +E EL M+ K + + + +K+ Q
Sbjct: 1580 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1636
Query: 130 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 187
+ +A + Y V ++ +S+ + PES + R ++ L+ + + RG L
Sbjct: 1637 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1696
Query: 188 RQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 247
R L Q ++ L Q W+A + + L E
Sbjct: 1697 RHRLFQLN-------------REVDDLEQ----WIAEREVVAGSHELGQDYEHVTMLQER 1739
Query: 248 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK 290
RE + + Q +VD + +++ L+ GH + AE K
Sbjct: 1740 FREFARDTGNI--GQERVDTVNHLADELINSGHSDAATIAEWK 1780
Score = 32.0 bits (71), Expect = 1.1
Identities = 44/239 (18%), Positives = 91/239 (38%), Gaps = 28/239 (11%)
Query: 71 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--Q 128
A EL +LK ++LQ+ D ++ W+ E + A+ S + L K L Q
Sbjct: 1264 ASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQ 1317
Query: 129 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 188
+ + K + + + + + ++ +L L +WE +
Sbjct: 1318 AFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ------- 1370
Query: 189 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECR 248
+K + D + F Q +L WL +++ Q LL
Sbjct: 1371 --------TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL--- 1419
Query: 249 RELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 307
++ LE ++ R+ +++ LQ + +L +G D E + K ++ K +L E +++
Sbjct: 1420 KKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTD--EVDSKRLTVQTKFMELLEPLNE 1476
Score = 30.8 bits (68), Expect = 2.5
Identities = 56/294 (19%), Positives = 118/294 (40%), Gaps = 37/294 (12%)
Query: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 88
+D KE ++ + +P Q L+ + E D WE ++ + + + + LQQ
Sbjct: 1013 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1068
Query: 89 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 148
D+ +WL +T+ + M P+ + E E + + + I D Y+ +
Sbjct: 1069 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1125
Query: 149 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLF 207
+ Q ++ + L+ RL+ L W ++ + L QS Q + +++
Sbjct: 1126 EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL 1185
Query: 208 FKDFHQLSQNLL---LWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 264
+ L+ + L A A ++Q+ +T A+ + +
Sbjct: 1186 NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDAN---------------------EEK 1224
Query: 265 VDMLQEISNSLLIKGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317
++ + E L+ G+ D I +EKV I+ + ++ RE S+ LM L+ ++
Sbjct: 1225 INAVVETGRRLVSDGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1276
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 42.7 bits (99), Expect = 6e-04
Identities = 53/242 (21%), Positives = 103/242 (42%), Gaps = 17/242 (7%)
Query: 69 IQAQELHNK-LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQ-EIELRVKR 126
I +EL K K+++ LQ + S+ S I +K+ + +LE K+ P +Q E + K
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 127 LQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA-QGAVDSWRG 185
LQ + + + V E + + E R + WE Q + R
Sbjct: 274 LQSV--------SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 186 GLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 245
++ ++ Q K R + ++++ K+ Q ++W K RRQ+ + + + R
Sbjct: 326 --QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 383
Query: 246 ECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQV 305
E E + +EL E+ + + ++E K E+ I +EK E K+ + E++
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQEEKI 439
Query: 306 SQ 307
+
Sbjct: 440 RE 441
Score = 30.8 bits (68), Expect = 2.5
Identities = 44/264 (16%), Positives = 105/264 (39%), Gaps = 15/264 (5%)
Query: 55 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAI----TTWLKKTEAELEMLKM 110
I EQ+ + + E I QE + + +Q +++ I W +K + + K+
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Query: 111 AKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLS 170
K + E +++ +E ++ + + +E E E + ++ +
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIREQEE--------KMWRQEEKIREQEEMWREEEKMHEQE 557
Query: 171 LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQ 230
+WE + + ++ ++ Q K + + + ++ + Q +W K R Q
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 231 KAHVTDPKADPRALLECRRELMQLEKELVERQ-PQVDMLQEISNSLLIKGHGEDCIEAEE 289
+ + + + R E RE ++ +E E+ Q + + E + + E EE
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM--QEQEETMWRQEE 675
Query: 290 KVHVIEKKLKQLREQVSQDLMALQ 313
K+ EKK+++ E++ + +Q
Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQ 699
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 29/242 (11%)
Query: 71 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL-RVKRLQE 129
A LH+ LQ+ +SA++TW KK + +E L + D +EL R E
Sbjct: 130 AGRLHHSWHFAGELQRA---LSAVSTWHKKADRYIEELTKER---DALSLELYRNTITNE 183
Query: 130 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 189
LK N +E L+ E +E+Q +++L E A+ + + Q
Sbjct: 184 ELK----------KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 233
Query: 190 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
M Q + R + + ++ Q L K R Q+ + + + L E +
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM---RRQEKRLREQEK 290
Query: 250 ELMQLEKELVER---QPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKL----KQLR 302
EL + EKEL E+ + Q + +QE + E E EEK+ E++L KQ+R
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMW--EQEEKMREQEEKMWRQEERLWEQEKQMR 348
Query: 303 EQ 304
EQ
Sbjct: 349 EQ 350
>gi|24233517 IKK interacting protein isoform 1 [Homo sapiens]
Length = 377
Score = 42.4 bits (98), Expect = 8e-04
Identities = 72/311 (23%), Positives = 139/311 (44%), Gaps = 56/311 (18%)
Query: 51 GLAGITEQQSGAFDRWEMIQAQELHNKLKIKQN-LQQLNSDISAITTWLKKTEAELE--- 106
GLA QQS F + E + LK++ N QQL S IS I+ L+ TE+ L+
Sbjct: 57 GLAWFVFQQSEKFAKVE-----NQYQLLKLETNEFQQLQSKISLISEKLESTESILQEAT 111
Query: 107 -----MLKMAKPPSDIQEI--------ELRVKRLQEILKAF----DTYKALVVSVNVSS- 148
M + + S++Q+I E+ +R+Q + + F D +K + +N+++
Sbjct: 112 SSMSLMTQFEQEVSNLQDIMHDIQNNEEVLTQRMQSLNEKFQNITDFWKRSLEEMNINTD 171
Query: 149 ---KEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR-------QSLMQCQ--- 195
E S + ++ S +++ LL E + DS +R + L++ +
Sbjct: 172 IFKSEAKHIHSQVTVQINSAEQEIKLLTERLKDLEDSTLRNIRTVKRQEEEDLLRVEEQL 231
Query: 196 GSKTR------PRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 249
GS T+ LF +D L+ L + K K H+ ++ ++L +
Sbjct: 232 GSDTKAIEKLEEEQHALFARD-EDLTNKLSDY--EPKVEECKTHLPTIESAIHSVLRVSQ 288
Query: 250 ELMQLEKELVERQPQV-----DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQ 304
+L++ EK++ + Q+ DML+ +S + ++ E I+ + + ++ +L L+E+
Sbjct: 289 DLIETEKKMEDLTMQMFNMEDDMLKAVSEIMEMQKTLEG-IQYDNSILKMQNELDILKEK 347
Query: 305 VSQDLMALQGT 315
V D +A T
Sbjct: 348 V-HDFIAYSST 357
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/245 (21%), Positives = 105/245 (42%), Gaps = 16/245 (6%)
Query: 69 IQAQELHNK-LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQ-EIELRVKR 126
I +EL K K+++ LQ + S+ S I +K+ + +LE K+ P +Q E + K
Sbjct: 275 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 334
Query: 127 LQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA-QGAVDSWRG 185
LQ + + + V E + + E R + WE Q + R
Sbjct: 335 LQSV--------SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 186 GLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 245
++ ++ Q K R + ++++ K+ Q ++W K RRQ+ + + + R L
Sbjct: 387 --QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 246 ECRRELMQLEKELVERQPQVDMLQE---ISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 302
E E ++ ++ +RQ + + ++ + E E EEK+ E+K+ +
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 303 EQVSQ 307
E++ +
Sbjct: 505 EKIHE 509
Score = 29.3 bits (64), Expect = 7.2
Identities = 43/257 (16%), Positives = 105/257 (40%), Gaps = 18/257 (7%)
Query: 57 EQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD 116
E QS + ++ EL N+L +Q + + I W +K + + E K+ +
Sbjct: 334 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE-EKIQEWEEKIQEQEE--KIREQEEK 390
Query: 117 IQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 176
I+E E +++R +E++ + + +E ++ + E + ++R+L
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 177 QGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQL--------SQNLLLWLASAKNR 228
+ + RQ + + + R + ++ ++ Q +W K
Sbjct: 451 EKIREQEEK--RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH 508
Query: 229 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 288
Q+ + K + + + E ++ ++E+ ++ ++ +E I+ E E
Sbjct: 509 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE-----KIRKQEEKMWRQE 563
Query: 289 EKVHVIEKKLKQLREQV 305
EK+H E+K+++ E+V
Sbjct: 564 EKMHDQEEKIREQEEKV 580
Score = 28.9 bits (63), Expect = 9.4
Identities = 43/242 (17%), Positives = 101/242 (41%), Gaps = 21/242 (8%)
Query: 72 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 131
+++H + KI++ ++ + I K+ E E KM + I+E E +++ +E
Sbjct: 445 EKMHEQEKIREQ-EEKRQEEEKIREQEKRQEQEA---KMWRQEEKIREQEEKIREQEE-- 498
Query: 132 KAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSL 191
K + + + + +E Q E E + ++R+ +W + + ++
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQ-EQEEMWRQEEKIREQEEIWRQKEKIHE------QEEK 551
Query: 192 MQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL 251
++ Q K + + + ++ Q +W K R Q+ + + + R + E+
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE----QEEM 607
Query: 252 MQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMA 311
Q ++E + Q + QE ++ E EEK+ EKK+++ E++ +
Sbjct: 608 TQEQEEKMGEQEEKMCEQEEK----MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 663
Query: 312 LQ 313
+Q
Sbjct: 664 MQ 665
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 40.4 bits (93), Expect = 0.003
Identities = 56/244 (22%), Positives = 100/244 (40%), Gaps = 33/244 (13%)
Query: 78 LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTY 137
LK LQ+L D + W+ K + L + DIQ ++ RV++ Q K
Sbjct: 578 LKESLLLQKLYEDSDDLKNWINKKKK----LADDEDYKDIQNLKSRVQKQQVFEKELAVN 633
Query: 138 KALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGS 197
K + ++ + +E ++ S + +RL +++ LWE A L ++ Q Q
Sbjct: 634 KTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-- 691
Query: 198 KTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ---L 254
F +++L WL + + VT + L E + L + L
Sbjct: 692 -------------FENNAEDLQRWLEDVEWQ-----VTSEDYG-KGLAEVQNRLRKHGLL 732
Query: 255 EKELVERQPQVDMLQEISNSLLIKGH--GEDCIEAEEKVHVIEKKLKQ---LREQVSQDL 309
E + RQ QVD+L +++ GH +D +E + + LK+ R++ DL
Sbjct: 733 ESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDL 792
Query: 310 MALQ 313
+ LQ
Sbjct: 793 LHLQ 796
Score = 37.0 bits (84), Expect = 0.034
Identities = 40/236 (16%), Positives = 95/236 (40%), Gaps = 27/236 (11%)
Query: 55 ITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK 112
I E + WE I+A + KL+ + +SD ++ W+ + A + ++
Sbjct: 341 IQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADEL-- 398
Query: 113 PPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLL 172
P+D+ E+ + R Q+ D+Y S + + ++ + S E++ ++ L
Sbjct: 399 -PTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNN 457
Query: 173 WEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKA 232
W A L++ + R L F F++ S+ + W++ + +
Sbjct: 458 WTA---------------LLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENE 502
Query: 233 HVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 288
+ + ALL+ + E+ ++ ++ + + + L+ G+D ++E
Sbjct: 503 DLGNSLGSAEALLQKHED---FEEAFTAQEEKIITVDKTATKLI----GDDHYDSE 551
Score = 33.9 bits (76), Expect = 0.29
Identities = 41/249 (16%), Positives = 102/249 (40%), Gaps = 34/249 (13%)
Query: 37 GPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDISAI 94
G ++N N + D + E+ + W + E H + + + D +
Sbjct: 433 GQDLVNANHEASDE----VREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQV 488
Query: 95 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 154
+W+ + EA LE + + + E +++ ++ +AF + +++V+ ++ + +
Sbjct: 489 DSWMSRQEAFLENEDLG---NSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGD 545
Query: 155 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL---RQSLMQCQGSKTRPRSDVLFFKDF 211
+ +S +++ R GL R +L + ++ R + L +
Sbjct: 546 DHYDSENIKAI------------------RDGLLARRDALREKAATRRRLLKESLLLQKL 587
Query: 212 HQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEI 271
++ S +L W+ N+++K + D + L ++ EKEL + Q++ +Q+
Sbjct: 588 YEDSDDLKNWI----NKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKT 643
Query: 272 SNSLLIKGH 280
++ GH
Sbjct: 644 GQEMIEGGH 652
Score = 32.0 bits (71), Expect = 1.1
Identities = 23/109 (21%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 70 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 129
+ +L LK +Q +Q+ + I W+ EA +++ + D + E+ K+ ++
Sbjct: 150 KGDQLLRALKFQQYVQEC----ADILEWIGDKEAIATSVELGE---DWERTEVLHKKFED 202
Query: 130 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 178
+ VV VN + E + P+ +QS+ +++ WE +G
Sbjct: 203 FQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRG 251
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,638,094
Number of Sequences: 37866
Number of extensions: 899676
Number of successful extensions: 4968
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 259
Number of HSP's that attempted gapping in prelim test: 4471
Number of HSP's gapped (non-prelim): 715
length of query: 429
length of database: 18,247,518
effective HSP length: 105
effective length of query: 324
effective length of database: 14,271,588
effective search space: 4623994512
effective search space used: 4623994512
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.