BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|33598916 claudin 10 isoform a [Homo sapiens] (226 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|33598916 claudin 10 isoform a [Homo sapiens] 465 e-131 gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] 412 e-116 gi|5921465 claudin 10 isoform b [Homo sapiens] 346 8e-96 gi|7656981 claudin 15 [Homo sapiens] 155 2e-38 gi|183979973 claudin 19 isoform a [Homo sapiens] 152 2e-37 gi|183979975 claudin 19 isoform b [Homo sapiens] 152 2e-37 gi|153792186 claudin 7 [Homo sapiens] 145 2e-35 gi|7705961 claudin 18 isoform 1 [Homo sapiens] 135 3e-32 gi|50345279 claudin 18 isoform 2 [Homo sapiens] 134 8e-32 gi|10863887 claudin 1 [Homo sapiens] 129 2e-30 gi|40788011 claudin 8 [Homo sapiens] 126 2e-29 gi|4502875 claudin 3 [Homo sapiens] 124 5e-29 gi|195947374 claudin 5 [Homo sapiens] 122 2e-28 gi|195947372 claudin 5 [Homo sapiens] 122 2e-28 gi|4502877 claudin 4 [Homo sapiens] 116 1e-26 gi|6912316 claudin 17 [Homo sapiens] 111 4e-25 gi|153792768 claudin 6 [Homo sapiens] 109 2e-24 gi|225703142 claudin 14 [Homo sapiens] 108 4e-24 gi|21536294 claudin 14 [Homo sapiens] 108 4e-24 gi|225703138 claudin 14 [Homo sapiens] 108 4e-24 gi|6912314 claudin 14 [Homo sapiens] 108 4e-24 gi|225703140 claudin 14 [Homo sapiens] 108 4e-24 gi|11141861 claudin 9 [Homo sapiens] 107 6e-24 gi|47716519 claudin 20 [Homo sapiens] 107 6e-24 gi|9966781 claudin 2 [Homo sapiens] 103 1e-22 gi|10938016 claudin 11 [Homo sapiens] 88 5e-18 gi|162417973 claudin 22 [Homo sapiens] 73 2e-13 gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] 72 3e-13 gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] 72 3e-13 gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] 72 3e-13 >gi|33598916 claudin 10 isoform a [Homo sapiens] Length = 226 Score = 465 bits (1197), Expect = e-131 Identities = 226/226 (100%), Positives = 226/226 (100%) Query: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFH 60 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFH Sbjct: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFH 60 Query: 61 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI 120 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI Sbjct: 61 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI 120 Query: 121 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS 180 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS Sbjct: 121 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS 180 Query: 181 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 226 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV Sbjct: 181 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 226 >gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] Length = 207 Score = 412 bits (1060), Expect = e-116 Identities = 207/226 (91%), Positives = 207/226 (91%), Gaps = 19/226 (8%) Query: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFH 60 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAG Sbjct: 1 MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAG------- 53 Query: 61 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI 120 YIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI Sbjct: 54 ------------YIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGI 101 Query: 121 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS 180 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS Sbjct: 102 VFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFS 161 Query: 181 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 226 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV Sbjct: 162 ISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 207 >gi|5921465 claudin 10 isoform b [Homo sapiens] Length = 228 Score = 346 bits (888), Expect = 8e-96 Identities = 170/223 (76%), Positives = 189/223 (84%) Query: 4 AQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRP 63 ++I A + + G+ + + ++ WKV+T +VIT + LW C ++ G +C+ Sbjct: 6 SEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGVSNCKD 65 Query: 64 HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 123 ++ + GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI Sbjct: 66 FPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 125 Query: 124 LSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISD 183 LSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISD Sbjct: 126 LSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISD 185 Query: 184 NNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 226 NNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV Sbjct: 186 NNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 228 >gi|7656981 claudin 15 [Homo sapiens] Length = 228 Score = 155 bits (393), Expect = 2e-38 Identities = 83/218 (38%), Positives = 127/218 (58%), Gaps = 13/218 (5%) Query: 17 GALVAATT--SNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGYI 74 G L+ T ++ W+V+T +VIT +++ LW +CA ++LG ++C ++ ++GYI Sbjct: 16 GLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNCWEFPSMLALSGYI 75 Query: 75 QACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSD-KAKAKIACLAGIVFILSGLCSMTGC 133 QACR LMI A+ LGF G + + G++CT +GG + KAK+A AG + IL+G+C M Sbjct: 76 QACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHILAGICGMVAI 135 Query: 134 SLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCF-----SISDNNKTP 188 S YA IT +FFDPL+ KYELG AL++GW+ + + I+GG+ C S D + Sbjct: 136 SWYAFNITRDFFDPLYPGTKYELGPALYLGWSASLISILGGLCLCSACCCGSDEDPAASA 195 Query: 189 RYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 226 R Y SVM T G+ + ++ +NAYV Sbjct: 196 RRPYQAPVSVMPVATSDQEGD-----SSFGKYGRNAYV 228 >gi|183979973 claudin 19 isoform a [Homo sapiens] Length = 224 Score = 152 bits (384), Expect = 2e-37 Identities = 74/180 (41%), Positives = 114/180 (63%), Gaps = 3/180 (1%) Query: 2 SRAQIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFH 60 S Q+ +GG+ ++A+T +WK ++ A ++ITA +Y+GLWM+CA + G Sbjct: 4 SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63 Query: 61 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAG 119 C+ + ++ + G+IQ+ R LM+ AV LGF + ++ GMKCT+VG S+ AK ++A G Sbjct: 64 CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123 Query: 120 IVFILSGLCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFC 178 +FIL+GLC++T S YA +T EFF+P V +YE G ALF+GWA A L ++GG C Sbjct: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLC 183 >gi|183979975 claudin 19 isoform b [Homo sapiens] Length = 211 Score = 152 bits (384), Expect = 2e-37 Identities = 74/180 (41%), Positives = 114/180 (63%), Gaps = 3/180 (1%) Query: 2 SRAQIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFH 60 S Q+ +GG+ ++A+T +WK ++ A ++ITA +Y+GLWM+CA + G Sbjct: 4 SGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ 63 Query: 61 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDK-AKAKIACLAG 119 C+ + ++ + G+IQ+ R LM+ AV LGF + ++ GMKCT+VG S+ AK ++A G Sbjct: 64 CKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123 Query: 120 IVFILSGLCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFC 178 +FIL+GLC++T S YA +T EFF+P V +YE G ALF+GWA A L ++GG C Sbjct: 124 ALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLC 183 >gi|153792186 claudin 7 [Homo sapiens] Length = 211 Score = 145 bits (367), Expect = 2e-35 Identities = 72/179 (40%), Positives = 111/179 (62%), Gaps = 3/179 (1%) Query: 15 GFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGY 73 G+ LVA T +W++++ A ++ITA +Y+GLWM+C + G C+ + ++ ++ Sbjct: 17 GWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAA 76 Query: 74 IQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA-KAKIACLAGIVFILSGLCSMTG 132 +QA R LM+ ++ LGF A GMKCT+ GG DK KA+IA GI+FI++GL ++ Sbjct: 77 LQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGGIIFIVAGLAALVA 136 Query: 133 CSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRY 190 CS Y ++I T+F++PL KYE G A+FIGWAG++L I+GG + S N Y Sbjct: 137 CSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGALLSCSCPGNESKAGY 195 >gi|7705961 claudin 18 isoform 1 [Homo sapiens] Length = 261 Score = 135 bits (340), Expect = 3e-32 Identities = 82/251 (32%), Positives = 124/251 (49%), Gaps = 37/251 (14%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRPH 64 Q+ A + + G +AAT + W + +T+ + Y+GLW +C + G CRP+ Sbjct: 7 QVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPY 66 Query: 65 FTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGG-SDKAKAKIACLAGIVFI 123 FTI + +QA R LMI + LG G + ++F +KC ++G D AKA + +GI+FI Sbjct: 67 FTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFI 126 Query: 124 LSGLCSMTGCSLYANKITTEFFDPL------------FVEQKYELGAALFIGWAGASLCI 171 +SGLC++ G S++AN + T F+ V+ +Y GAALF+GW L + Sbjct: 127 VSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTL 186 Query: 172 IGGVIFCFSI------SDNNKTPRYTYNG-----------ATSVMSSRTK----YHGG-- 208 IGGV+ C + N K Y +G A++ S TK Y GG Sbjct: 187 IGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGAR 246 Query: 209 -EDFKTTNPSK 218 ED + PSK Sbjct: 247 TEDEVQSYPSK 257 >gi|50345279 claudin 18 isoform 2 [Homo sapiens] Length = 261 Score = 134 bits (336), Expect = 8e-32 Identities = 80/241 (33%), Positives = 121/241 (50%), Gaps = 37/241 (15%) Query: 15 GFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGYI 74 G ++AAT ++W ++ +TA + YQGLW +C + G CR +FT+ + + Sbjct: 17 GIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAML 76 Query: 75 QACRGLMIAAVSLGFFGSIFALFGMKCTKVGG-SDKAKAKIACLAGIVFILSGLCSMTGC 133 QA R LMI + LG G + ++F +KC ++G D AKA + +GI+FI+SGLC++ G Sbjct: 77 QAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGV 136 Query: 134 SLYANKITTEFFDPL------------FVEQKYELGAALFIGWAGASLCIIGGVIFCFSI 181 S++AN + T F+ V+ +Y GAALF+GW L +IGGV+ C + Sbjct: 137 SVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIAC 196 Query: 182 ------SDNNKTPRYTYNG-----------ATSVMSSRTK----YHGG---EDFKTTNPS 217 N K Y +G A++ S TK Y GG ED + PS Sbjct: 197 RGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPS 256 Query: 218 K 218 K Sbjct: 257 K 257 >gi|10863887 claudin 1 [Homo sapiens] Length = 211 Score = 129 bits (324), Expect = 2e-30 Identities = 63/175 (36%), Positives = 104/175 (59%), Gaps = 4/175 (2%) Query: 9 LVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFHCRPHFTI 67 +++ +G GA+V+ T +W++ + A +++TA +Y+GLWM+C + G C+ ++ Sbjct: 12 ILAFLGWIGAIVS-TALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSL 70 Query: 68 FKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKA-KAKIACLAGIVFILSG 126 ++ +QA R LM+ + LG A GMKC K D+ K ++A + G +F+L+G Sbjct: 71 LNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAG 130 Query: 127 LCSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFCFS 180 L + + Y N+I EF+DP+ V +YE G ALF GWA ASLC++GG + C S Sbjct: 131 LAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCS 185 >gi|40788011 claudin 8 [Homo sapiens] Length = 225 Score = 126 bits (316), Expect = 2e-29 Identities = 73/214 (34%), Positives = 118/214 (55%), Gaps = 5/214 (2%) Query: 10 VSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRPHFTIF 68 + GVG G VA T +W+V+ ++++ ++GLWMNC A C+ + ++ Sbjct: 13 LGGVGMVGT-VAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANIRMQCKIYDSLL 71 Query: 69 KVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVFILSGL 127 ++ +QA RGLM AA + F + A+ GMKCT+ G ++K KA I AGI+FI++G+ Sbjct: 72 ALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILLTAGIIFIITGM 131 Query: 128 CSMTGCSLYANKITTEFFDPLF-VEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNK 186 + S AN I +F++ + V QK ELG AL++GW A + I+GG +FC N K Sbjct: 132 VVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGALFCCVFCCNEK 191 Query: 187 TPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQF 220 + Y Y+ S +++ YH G+ + Q+ Sbjct: 192 SSSYRYS-IPSHRTTQKSYHTGKKSPSVYSRSQY 224 >gi|4502875 claudin 3 [Homo sapiens] Length = 220 Score = 124 bits (312), Expect = 5e-29 Identities = 70/197 (35%), Positives = 113/197 (57%), Gaps = 8/197 (4%) Query: 13 VGGFGALVAATTSNEWKVTTR-ASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVA 71 +G G +V W+V+ S++IT+ +++GLWMNC + G C+ + ++ + Sbjct: 15 LGWLGTIVCCALPM-WRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALP 73 Query: 72 GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMT 131 +QA R L++ A+ L FG + AL G +CT D AKAKI +AG++F+L+ L ++ Sbjct: 74 QDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLV 133 Query: 132 GCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRY 190 S AN I +F++P+ E QK E+GA L++GWA A+L ++GG + C S K +Y Sbjct: 134 PVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREK--KY 191 Query: 191 TYNGATSVMSSRTKYHG 207 T AT V+ S + G Sbjct: 192 T---ATKVVYSAPRSTG 205 >gi|195947374 claudin 5 [Homo sapiens] Length = 303 Score = 122 bits (307), Expect = 2e-28 Identities = 62/176 (35%), Positives = 101/176 (57%), Gaps = 2/176 (1%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFHCRP 63 +I LV + G+G L+ A W+VT +++TA ++GLWM+C + G C+ Sbjct: 92 EILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKV 151 Query: 64 HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 123 + ++ ++ +QA R L ++AV L F L G +CT AKA++A G++++ Sbjct: 152 YDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYL 211 Query: 124 LSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFC 178 GL ++ +AN + EF+DP + V QKYELGAAL+IGWA +L ++GG + C Sbjct: 212 FCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLC 267 >gi|195947372 claudin 5 [Homo sapiens] Length = 303 Score = 122 bits (307), Expect = 2e-28 Identities = 62/176 (35%), Positives = 101/176 (57%), Gaps = 2/176 (1%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRAS-SVITATWVYQGLWMNCAGNALGSFHCRP 63 +I LV + G+G L+ A W+VT +++TA ++GLWM+C + G C+ Sbjct: 92 EILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKV 151 Query: 64 HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 123 + ++ ++ +QA R L ++AV L F L G +CT AKA++A G++++ Sbjct: 152 YDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYL 211 Query: 124 LSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFC 178 GL ++ +AN + EF+DP + V QKYELGAAL+IGWA +L ++GG + C Sbjct: 212 FCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLC 267 >gi|4502877 claudin 4 [Homo sapiens] Length = 209 Score = 116 bits (291), Expect = 1e-26 Identities = 62/200 (31%), Positives = 110/200 (55%), Gaps = 3/200 (1%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTR-ASSVITATWVYQGLWMNCAGNALGSFHCRP 63 Q+ + V G+ A++ W+VT S+++T+ +++GLWMNC + G C+ Sbjct: 7 QVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKV 66 Query: 64 HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 123 + ++ + +QA R L+I ++ + G + ++ G KCT + AKAK +AG+VF+ Sbjct: 67 YDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFL 126 Query: 124 LSGLCSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSIS 182 L+GL + S A+ I +F++PL QK E+GA+L++GWA + L ++GG + C + Sbjct: 127 LAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCP 186 Query: 183 DNNKTP-RYTYNGATSVMSS 201 P Y+ A S +S Sbjct: 187 PRTDKPYSAKYSAARSAAAS 206 >gi|6912316 claudin 17 [Homo sapiens] Length = 224 Score = 111 bits (278), Expect = 4e-25 Identities = 67/193 (34%), Positives = 105/193 (54%), Gaps = 7/193 (3%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRP 63 QI LV G G +A T +W+V+ S++I +++GLWMNC A C+ Sbjct: 7 QIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKF 66 Query: 64 HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMK---CTKVGGSDKAKAKIACLAGI 120 + ++ + ++ R LM AV+L + + GMK CT G +++AKA + +G+ Sbjct: 67 YSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT--GSNERAKAYLLGTSGV 124 Query: 121 VFILSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFCF 179 +FIL+G+ + S AN I +F++P + + QK ELGAALF+GWA A++ IGG + C Sbjct: 125 LFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCG 184 Query: 180 SISDNNKTPRYTY 192 N K Y Y Sbjct: 185 FCCCNRKKQGYRY 197 >gi|153792768 claudin 6 [Homo sapiens] Length = 220 Score = 109 bits (273), Expect = 2e-24 Identities = 54/153 (35%), Positives = 91/153 (59%), Gaps = 2/153 (1%) Query: 28 WKVTTR-ASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGYIQACRGLMIAAVS 86 WKVT +S++ A V++GLWM+C + G C+ + ++ + +QA R L + A+ Sbjct: 30 WKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALL 89 Query: 87 LGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFD 146 + FG + L G KCT +KA++ +GIVF++SG+ ++ A+ I +F++ Sbjct: 90 VALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYN 149 Query: 147 PLFVE-QKYELGAALFIGWAGASLCIIGGVIFC 178 PL E QK ELGA+L++GWA + L ++GG + C Sbjct: 150 PLVAEAQKRELGASLYLGWAASGLLLLGGGLLC 182 >gi|225703142 claudin 14 [Homo sapiens] Length = 239 Score = 108 bits (270), Expect = 4e-24 Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 3/177 (1%) Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRPHFTI 67 L+S +G G L+ T W+ T ++++TA +GLWM C ++ G + C+ + ++ Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70 Query: 68 FKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 127 + +QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130 Query: 128 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 183 M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187 >gi|21536294 claudin 14 [Homo sapiens] Length = 239 Score = 108 bits (270), Expect = 4e-24 Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 3/177 (1%) Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRPHFTI 67 L+S +G G L+ T W+ T ++++TA +GLWM C ++ G + C+ + ++ Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70 Query: 68 FKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 127 + +QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130 Query: 128 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 183 M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187 >gi|225703138 claudin 14 [Homo sapiens] Length = 239 Score = 108 bits (270), Expect = 4e-24 Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 3/177 (1%) Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRPHFTI 67 L+S +G G L+ T W+ T ++++TA +GLWM C ++ G + C+ + ++ Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70 Query: 68 FKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 127 + +QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130 Query: 128 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 183 M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187 >gi|6912314 claudin 14 [Homo sapiens] Length = 239 Score = 108 bits (270), Expect = 4e-24 Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 3/177 (1%) Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRPHFTI 67 L+S +G G L+ T W+ T ++++TA +GLWM C ++ G + C+ + ++ Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70 Query: 68 FKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 127 + +QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130 Query: 128 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 183 M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187 >gi|225703140 claudin 14 [Homo sapiens] Length = 239 Score = 108 bits (270), Expect = 4e-24 Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 3/177 (1%) Query: 9 LVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRPHFTI 67 L+S +G G L+ T W+ T ++++TA +GLWM C ++ G + C+ + ++ Sbjct: 12 LLSFLGMVGTLIT-TILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSL 70 Query: 68 FKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGL 127 + +QA R LM+ + L A+ GMKCT+ AK A L G +FIL+GL Sbjct: 71 LALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGL 130 Query: 128 CSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSISD 183 M S N + F++PL K+E+G AL++G+ +SL +IGG + C S D Sbjct: 131 LCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQD 187 >gi|11141861 claudin 9 [Homo sapiens] Length = 217 Score = 107 bits (268), Expect = 6e-24 Identities = 57/168 (33%), Positives = 96/168 (57%), Gaps = 3/168 (1%) Query: 13 VGGFGALVAATTSNEWKVTTR-ASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVA 71 +G G LV+ WKVT +S++ A V++GLWM+C + G C+ + ++ + Sbjct: 16 LGWLGTLVSCALPL-WKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALP 74 Query: 72 GYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMT 131 +QA R L + A+ L G + A+ G +CT + AKA+I AG++ +L+G+ + Sbjct: 75 QDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLI 134 Query: 132 GCSLYANKITTEFFDPLFVEQ-KYELGAALFIGWAGASLCIIGGVIFC 178 A+ I +F++PL E K ELGA+L++GWA A+L ++GG + C Sbjct: 135 PVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLC 182 >gi|47716519 claudin 20 [Homo sapiens] Length = 219 Score = 107 bits (268), Expect = 6e-24 Identities = 61/187 (32%), Positives = 92/187 (49%), Gaps = 2/187 (1%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRP 63 Q+ A + + G ++ AT WKV S++ITA GLWM+C + G F C Sbjct: 7 QLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDCTWYSTGMFSCAL 66 Query: 64 HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 123 +I + ++QA R M+ A L G + GMKCT++GG + K+ + G+ F+ Sbjct: 67 KHSILSLPIHVQAARATMVLACVLSALGICTSTVGMKCTRLGGDRETKSHASFAGGVCFM 126 Query: 124 LSGLCSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSIS 182 +G+ S+ Y +I F D E K+E G A++IG+ A L I G+IFC S Sbjct: 127 SAGISSLISTVWYTKEIIANFLDLTVPESNKHEPGGAIYIGFISAMLLFISGMIFCTSCI 186 Query: 183 DNNKTPR 189 N R Sbjct: 187 KRNPEAR 193 >gi|9966781 claudin 2 [Homo sapiens] Length = 230 Score = 103 bits (257), Expect = 1e-22 Identities = 59/224 (26%), Positives = 106/224 (47%), Gaps = 2/224 (0%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRP 63 Q+ + G+ G + A WK ++ +S++TA +GLWM CA ++ G C Sbjct: 7 QLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDI 66 Query: 64 HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFI 123 + T+ + IQA + +M+ + ++ I ++ GM+CT +AK ++A G+ FI Sbjct: 67 YSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVFFI 126 Query: 124 LSGLCSMTGCSLYANKITTEFFDPLFVE-QKYELGAALFIGWAGASLCIIGGVIFCFSIS 182 L GL + + I +F+ PL + K+E+G AL++G + +I G+I CFS S Sbjct: 127 LGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFSCS 186 Query: 183 DNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV 226 Y +++R+ G+ K + + YV Sbjct: 187 SQRNRSNYYDAYQAQPLATRSSPRPGQPPKVKSEFNSYSLTGYV 230 >gi|10938016 claudin 11 [Homo sapiens] Length = 207 Score = 88.2 bits (217), Expect = 5e-18 Identities = 61/183 (33%), Positives = 94/183 (51%), Gaps = 21/183 (11%) Query: 5 QIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQ----GLWMNCAGNALGSFH 60 Q+ V+ G+ ++ T++N+W VT ++ T + + GLW +C A G +H Sbjct: 7 QVVGFVTSFVGWIGVIVTTSTNDWVVTC-GYTIPTCRKLDELGSKGLWADCV-MATGLYH 64 Query: 61 CRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGS-DKAKAKIACLAG 119 C+P I + GY+QACR LMIAA LG + L + C ++G AK + A LAG Sbjct: 65 CKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAG 124 Query: 120 IVFILSGLCSMTGCSLY---ANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGG-V 175 ++ IL LC++ + A++ TT G +L+ GW GA LC++GG V Sbjct: 125 VLLILLALCALVATIWFPVCAHRETT----------IVSFGYSLYAGWIGAVLCLVGGCV 174 Query: 176 IFC 178 I C Sbjct: 175 ILC 177 >gi|162417973 claudin 22 [Homo sapiens] Length = 220 Score = 72.8 bits (177), Expect = 2e-13 Identities = 46/144 (31%), Positives = 74/144 (51%), Gaps = 6/144 (4%) Query: 46 GLWMNCAGNALGSFHCRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVG 105 GLW C C+ + + ++ R LM + LGF G + + FG+ C ++G Sbjct: 49 GLWQTCVIQEEVGMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIG 108 Query: 106 GSDK-AKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFD---PLFVEQKYELGAALF 161 S + K ++ L GI+ SG+ ++ S A+K EF+D P FV ++E G ALF Sbjct: 109 ESQRDLKRRLLILGGILSWASGVTALVPVSWVAHKTVQEFWDENVPDFV-PRWEFGEALF 167 Query: 162 IGW-AGASLCIIGGVIFCFSISDN 184 +GW AG SL + G ++ C + S + Sbjct: 168 LGWFAGLSLLLGGCLLHCAACSSH 191 >gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 72.4 bits (176), Expect = 3e-13 Identities = 46/144 (31%), Positives = 74/144 (51%), Gaps = 6/144 (4%) Query: 46 GLWMNCAGNALGSFHCRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVG 105 GLW C C+ + + ++ R LM + LGF G + + FG+ C ++G Sbjct: 49 GLWQTCVIQEEVGMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIG 108 Query: 106 GSDK-AKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFD---PLFVEQKYELGAALF 161 S + K ++ L GI+ SG+ ++ S A+K EF+D P FV ++E G ALF Sbjct: 109 ESQRDLKRRLLILGGILSWASGITALVPVSWVAHKTVQEFWDENVPDFV-PRWEFGEALF 167 Query: 162 IGW-AGASLCIIGGVIFCFSISDN 184 +GW AG SL + G ++ C + S + Sbjct: 168 LGWFAGLSLLLGGCLLNCAACSSH 191 >gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 72.4 bits (176), Expect = 3e-13 Identities = 46/144 (31%), Positives = 74/144 (51%), Gaps = 6/144 (4%) Query: 46 GLWMNCAGNALGSFHCRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVG 105 GLW C C+ + + ++ R LM + LGF G + + FG+ C ++G Sbjct: 49 GLWQTCVIQEEVGMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIG 108 Query: 106 GSDK-AKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFD---PLFVEQKYELGAALF 161 S + K ++ L GI+ SG+ ++ S A+K EF+D P FV ++E G ALF Sbjct: 109 ESQRDLKRRLLILGGILSWASGITALVPVSWVAHKTVQEFWDENVPDFV-PRWEFGEALF 167 Query: 162 IGW-AGASLCIIGGVIFCFSISDN 184 +GW AG SL + G ++ C + S + Sbjct: 168 LGWFAGLSLLLGGCLLNCAACSSH 191 >gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 72.4 bits (176), Expect = 3e-13 Identities = 46/144 (31%), Positives = 74/144 (51%), Gaps = 6/144 (4%) Query: 46 GLWMNCAGNALGSFHCRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVG 105 GLW C C+ + + ++ R LM + LGF G + + FG+ C ++G Sbjct: 49 GLWQTCVIQEEVGMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIG 108 Query: 106 GSDK-AKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFD---PLFVEQKYELGAALF 161 S + K ++ L GI+ SG+ ++ S A+K EF+D P FV ++E G ALF Sbjct: 109 ESQRDLKRRLLILGGILSWASGITALVPVSWVAHKTVQEFWDENVPDFV-PRWEFGEALF 167 Query: 162 IGW-AGASLCIIGGVIFCFSISDN 184 +GW AG SL + G ++ C + S + Sbjct: 168 LGWFAGLSLLLGGCLLNCAACSSH 191 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.136 0.433 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 7,857,752 Number of Sequences: 37866 Number of extensions: 296182 Number of successful extensions: 933 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 38 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 829 Number of HSP's gapped (non-prelim): 78 length of query: 226 length of database: 18,247,518 effective HSP length: 99 effective length of query: 127 effective length of database: 14,498,784 effective search space: 1841345568 effective search space used: 1841345568 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.