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Search of human proteins with 33519444
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33519444 amiloride-sensitive cation channel 4 isoform 2
[Homo sapiens]
(647 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 1327 0.0
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 1316 0.0
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 458 e-129
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 436 e-122
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 423 e-118
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 423 e-118
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 421 e-117
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 420 e-117
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 391 e-109
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 176 8e-44
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 126 5e-29
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 126 7e-29
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 126 7e-29
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 117 3e-26
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 117 3e-26
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 117 3e-26
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 93 9e-19
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 41 0.004
gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithora... 40 0.007
gi|30425428 deltex homolog 3 [Homo sapiens] 39 0.015
gi|90193619 nuclear matrix transcription factor 4 isoform c [Hom... 39 0.019
gi|90193617 nuclear matrix transcription factor 4 isoform b [Hom... 39 0.019
gi|90193615 nuclear matrix transcription factor 4 isoform b [Hom... 39 0.019
gi|90193613 nuclear matrix transcription factor 4 isoform a [Hom... 39 0.019
gi|90193611 nuclear matrix transcription factor 4 isoform a [Hom... 39 0.019
gi|36054194 nuclear matrix transcription factor 4 isoform a [Hom... 39 0.019
gi|209180475 nuclear matrix transcription factor 4 isoform d [Ho... 39 0.019
gi|40354197 THAP domain containing 11 [Homo sapiens] 39 0.019
gi|55750053 atrophin-1 [Homo sapiens] 39 0.019
gi|55750041 atrophin-1 [Homo sapiens] 39 0.019
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 1327 bits (3435), Expect = 0.0
Identities = 647/647 (100%), Positives = 647/647 (100%)
Query: 1 MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60
MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR
Sbjct: 1 MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60
Query: 61 QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120
QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA
Sbjct: 61 QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120
Query: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180
SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG
Sbjct: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180
Query: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240
LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP
Sbjct: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240
Query: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300
AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL
Sbjct: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300
Query: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360
ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE
Sbjct: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360
Query: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW
Sbjct: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
Query: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPEGPCFCP 480
GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPEGPCFCP
Sbjct: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPEGPCFCP 480
Query: 481 TPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRA 540
TPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRA
Sbjct: 481 TPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRA 540
Query: 541 AYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGIS 600
AYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGIS
Sbjct: 541 AYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGIS 600
Query: 601 TLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGLFEDFAC 647
TLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGLFEDFAC
Sbjct: 601 TLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGLFEDFAC 647
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 1316 bits (3405), Expect = 0.0
Identities = 647/666 (97%), Positives = 647/666 (97%), Gaps = 19/666 (2%)
Query: 1 MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60
MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR
Sbjct: 1 MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60
Query: 61 QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120
QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA
Sbjct: 61 QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120
Query: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180
SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG
Sbjct: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180
Query: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240
LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP
Sbjct: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240
Query: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300
AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL
Sbjct: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300
Query: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360
ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE
Sbjct: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360
Query: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW
Sbjct: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
Query: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP-------------- 466
GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP
Sbjct: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC 480
Query: 467 -----DSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 521
DSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF
Sbjct: 481 ADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 540
Query: 522 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 581
LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL
Sbjct: 541 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600
Query: 582 KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL 641
KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL
Sbjct: 601 KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL 660
Query: 642 FEDFAC 647
FEDFAC
Sbjct: 661 FEDFAC 666
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 458 bits (1179), Expect = e-129
Identities = 254/547 (46%), Positives = 332/547 (60%), Gaps = 61/547 (11%)
Query: 142 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL 201
+ K +E+E G G P + FAS+STLHGL L+R LWAL
Sbjct: 2 ELKAEEEEVG-----------GVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF 50
Query: 202 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF 261
L SLA L + Y H+ +D A + + FPAVTLCN+N FR S +S D++
Sbjct: 51 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRFSQVSKNDLY 109
Query: 262 HLANLTGL-------PPKDRDGHRAAGLRY---------PEP-DMVDILNRTGHQLADML 304
H L L P + + P+P +M + +R GH + DML
Sbjct: 110 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDML 169
Query: 305 KSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEY 362
SC+F G CSA +F VV+TRYGKCYTFN+ D R L + GG G+GLEIMLDIQQ+EY
Sbjct: 170 LSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEY 229
Query: 363 LPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGN 422
LP+W ET+ETSFEAGI+VQIHSQ+EPP+I QLGFGV+PGFQTFV+CQEQRL YLP PWG
Sbjct: 230 LPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 289
Query: 423 CRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP---------------- 466
C+A + + +L + +YS++ACR+ CE +++ C+CRMVHMP
Sbjct: 290 CKAVT--MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECAD 347
Query: 467 ---DSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLV 523
D L + C C PCNLTRYGKE+SMV+IP++ SA+YLA+K+N++E YI EN LV
Sbjct: 348 PALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILV 407
Query: 524 LDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKR 583
LD+FFE L E +EQ+ AY ++ LLGD+GGQMGLFIGASILT+LE+ DY YEV +L R
Sbjct: 408 LDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCR 467
Query: 584 VWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGV---SSLLPNHHHPHGPPGG 640
+ K R+S L L ++K +PC SL R G+ +++LP+H P G
Sbjct: 468 RGKCQKEAKRSSADKGVALSLDDVKRHNPCESL-RGHPAGMTYAANILPHH-----PARG 521
Query: 641 LFEDFAC 647
FEDF C
Sbjct: 522 TFEDFTC 528
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 436 bits (1122), Expect = e-122
Identities = 254/593 (42%), Positives = 332/593 (55%), Gaps = 107/593 (18%)
Query: 142 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL 201
+ K +E+E G G P + FAS+STLHGL L+R LWAL
Sbjct: 2 ELKAEEEEVG-----------GVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF 50
Query: 202 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF 261
L SLA L + Y H+ +D A + + FPAVTLCN+N FR S +S D++
Sbjct: 51 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRFSQVSKNDLY 109
Query: 262 HLANLTGL-------PPKDRDGHRAAGLRY---------PEP-DMVDILNRTGHQLADML 304
H L L P + + P+P +M + +R GH + DML
Sbjct: 110 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDML 169
Query: 305 KSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEY 362
SC+F G CSA +F VV+TRYGKCYTFN+ D R L + GG G+GLEIMLDIQQ+EY
Sbjct: 170 LSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEY 229
Query: 363 LPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGN 422
LP+W ET+ETSFEAGI+VQIHSQ+EPP+I QLGFGV+PGFQTFV+CQEQRL YLP PWG
Sbjct: 230 LPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 289
Query: 423 CRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP---------------- 466
C+A + + +L + +YS++ACR+ CE +++ C+CRMVHMP
Sbjct: 290 CKAVT--MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECAD 347
Query: 467 ---DSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLV 523
D L + C C PCNLTRYGKE+SMV+IP++ SA+YLA+K+N++E YI EN LV
Sbjct: 348 PALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILV 407
Query: 524 LDVFFEALTSEAMEQRAAYGLSAL------------------------------------ 547
LD+FFE L E +EQ+ AY ++ L
Sbjct: 408 LDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPP 467
Query: 548 ----------LGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTG 597
LGD+GGQMGLFIGASILT+LE+ DY YEV +L R + K R+S
Sbjct: 468 PQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSAD 527
Query: 598 GISTLGLQELKEQSPCPSLGRAEGGGV---SSLLPNHHHPHGPPGGLFEDFAC 647
L L ++K +PC SL R G+ +++LP+H P G FEDF C
Sbjct: 528 KGVALSLDDVKRHNPCESL-RGHPAGMTYAANILPHH-----PARGTFEDFTC 574
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 423 bits (1088), Expect = e-118
Identities = 238/491 (48%), Positives = 293/491 (59%), Gaps = 43/491 (8%)
Query: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227
D+ FAS ++HGLG GPG LRR +WA A++ S+A FLYQ A R Y H A
Sbjct: 16 DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75
Query: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286
+D + FPAVTLCNIN R S L+ D+ + L GL P + A R P
Sbjct: 76 LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134
Query: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335
P DM + R GH L DML C F G C NF+ ++TR GKCYTFN AD
Sbjct: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194
Query: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395
L + GGMG+GL+IMLD+QQEEYLP+WR+ ET FE GIRVQIHSQEEPP I QLG
Sbjct: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254
Query: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444
GVSPG+QTFVSCQ+Q+L++LP PWG+C + S L P Y++
Sbjct: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314
Query: 445 CRLRCEKEAVLQRCHCRMVHMPDSLGG-GPE----------------GPCFCPTPCNLTR 487
CRL CE V ++C CRMV+MP + P+ C CP PC TR
Sbjct: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTR 374
Query: 488 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 547
Y KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL E +EQ+ AY +S L
Sbjct: 375 YAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSEL 434
Query: 548 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTSTGGISTLGLQE 606
LGD+GGQMGLFIGAS+LT+LEILDY+ EV D+ L W R + +ST + GL
Sbjct: 435 LGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQE-GLGS 493
Query: 607 LKEQSPCPSLG 617
+ Q P SLG
Sbjct: 494 HRTQVPHLSLG 504
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 423 bits (1088), Expect = e-118
Identities = 238/491 (48%), Positives = 293/491 (59%), Gaps = 43/491 (8%)
Query: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227
D+ FAS ++HGLG GPG LRR +WA A++ S+A FLYQ A R Y H A
Sbjct: 16 DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75
Query: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286
+D + FPAVTLCNIN R S L+ D+ + L GL P + A R P
Sbjct: 76 LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134
Query: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335
P DM + R GH L DML C F G C NF+ ++TR GKCYTFN AD
Sbjct: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194
Query: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395
L + GGMG+GL+IMLD+QQEEYLP+WR+ ET FE GIRVQIHSQEEPP I QLG
Sbjct: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254
Query: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444
GVSPG+QTFVSCQ+Q+L++LP PWG+C + S L P Y++
Sbjct: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314
Query: 445 CRLRCEKEAVLQRCHCRMVHMPDSLGG-GPE----------------GPCFCPTPCNLTR 487
CRL CE V ++C CRMV+MP + P+ C CP PC TR
Sbjct: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTR 374
Query: 488 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 547
Y KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL E +EQ+ AY +S L
Sbjct: 375 YAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSEL 434
Query: 548 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTSTGGISTLGLQE 606
LGD+GGQMGLFIGAS+LT+LEILDY+ EV D+ L W R + +ST + GL
Sbjct: 435 LGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQE-GLGS 493
Query: 607 LKEQSPCPSLG 617
+ Q P SLG
Sbjct: 494 HRTQVPHLSLG 504
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 421 bits (1082), Expect = e-117
Identities = 219/454 (48%), Positives = 289/454 (63%), Gaps = 43/454 (9%)
Query: 166 PRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHL 225
P + FA+TSTLHG+ GP +RR LWA+A + SL L +++ Y + H+
Sbjct: 14 PSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHV 73
Query: 226 VAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDR---DGHRA--- 279
+D + FPAVTLCN+N FR S L+ D++H L L + D H A
Sbjct: 74 TKVDEVVAQSLV-FPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPS 132
Query: 280 --------AGLRYPEP---DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGK 328
A ++ +P M++ L+R GH L DM+ C F G C +F+ V+T+YGK
Sbjct: 133 VLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGK 192
Query: 329 CYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQE 386
CY FN+ D + L + GG G+GLEIMLDIQQ+EYLPIW ET ET+FEAG++VQIHSQ
Sbjct: 193 CYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQS 252
Query: 387 EPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACR 446
EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PWG CR+ E L + YS++ACR
Sbjct: 253 EPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSS----EMGLDFFPVYSITACR 308
Query: 447 LRCEKEAVLQRCHCRMVHMPDS-------------------LGGGPEGPCFCPTPCNLTR 487
+ CE +++ C+CRMVHMP L C C TPCNLTR
Sbjct: 309 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 368
Query: 488 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 547
Y KE+SMV+IP++ SA+YL +K+N++E YI EN LVLD+FFEAL E +EQ+ AY ++AL
Sbjct: 369 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428
Query: 548 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 581
LGD+GGQMGLFIGASILT+LE+ DYIYE+ ++L
Sbjct: 429 LGDIGGQMGLFIGASILTILELFDYIYELIKEKL 462
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 420 bits (1079), Expect = e-117
Identities = 231/470 (49%), Positives = 284/470 (60%), Gaps = 42/470 (8%)
Query: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227
D+ FAS ++HGLG GPG LRR +WA A++ S+A FLYQ A R Y H A
Sbjct: 16 DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75
Query: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286
+D + FPAVTLCNIN R S L+ D+ + L GL P + A R P
Sbjct: 76 LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134
Query: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335
P DM + R GH L DML C F G C NF+ ++TR GKCYTFN AD
Sbjct: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194
Query: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395
L + GGMG+GL+IMLD+QQEEYLP+WR+ ET FE GIRVQIHSQEEPP I QLG
Sbjct: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254
Query: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444
GVSPG+QTFVSCQ+Q+L++LP PWG+C + S L P Y++
Sbjct: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314
Query: 445 CRLRCEKEAVLQRCHCRMVHMPDSLGG-GPE----------------GPCFCPTPCNLTR 487
CRL CE V ++C CRMV+MP + P+ C CP PC TR
Sbjct: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTR 374
Query: 488 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 547
Y KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL E +EQ+ AY +S L
Sbjct: 375 YAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSEL 434
Query: 548 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTST 596
LGD+GGQMGLFIGAS+LT+LEILDY+ EV D+ L W R + +ST
Sbjct: 435 LGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSST 484
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 391 bits (1005), Expect = e-109
Identities = 222/480 (46%), Positives = 285/480 (59%), Gaps = 58/480 (12%)
Query: 151 GDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACG----PGPHGLRRTLWALALLTSLA 206
G E++L G PG A R + S + LHGL C G RR LW LA TS
Sbjct: 43 GGERALQG---PGVARRGRPSL-SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFG 98
Query: 207 AFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANL 266
L ++ +L+ P + + FPAVT+CN N R LS D+++ +
Sbjct: 99 LLLSWSSNRLLYWLSFPSHTRVHREWSRQLP-FPAVTVCNNNPLRFPRLSKGDLYYAGHW 157
Query: 267 TGLPPKDRDGHRAAG--LRYPEP------DMVD----------------ILNRTGHQLAD 302
GL +R LR EP + D ++R GHQL D
Sbjct: 158 LGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLED 217
Query: 303 MLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQE 360
ML SC + G C NFS V+T+YGKCY FN+ D + L + GG G+GLEIMLDIQQ+
Sbjct: 218 MLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 277
Query: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
EYLPIW ET ET+FEAG++VQIHSQ EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PW
Sbjct: 278 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 337
Query: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDS------------ 468
G CR+ E L + YS++ACR+ CE +++ C+CRMVHMP
Sbjct: 338 GECRSS----EMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKEC 393
Query: 469 -------LGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 521
L C C TPCNLTRY KE+SMV+IP++ SA+YL +K+N++E YI EN
Sbjct: 394 AEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENI 453
Query: 522 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 581
LVLD+FFEAL E +EQ+ AY ++ALLGD+GGQMGLFIGASILT+LE+ DYIYE+ ++L
Sbjct: 454 LVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKL 513
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 176 bits (445), Expect = 8e-44
Identities = 121/443 (27%), Positives = 202/443 (45%), Gaps = 55/443 (12%)
Query: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
FA +++ HG+ +RR LW + +L S++ +Q Y T P +++
Sbjct: 41 FAISTSFHGIHNIV-QNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
Query: 232 APAPVAGFPAVTLCNINRFRHSALSD-----------ADIFHLANLTGLPPKDRDGHRAA 280
+ FPAVT CN+NRF+ A++ + + HL +T R+ A
Sbjct: 100 YVEKME-FPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFA 158
Query: 281 GLRYPEPDMVDILNRTGHQLADM-LKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSS 339
+ +V+ + G L + L C F G CS +F+ V+T YG C+TFN
Sbjct: 159 A-SHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQ 217
Query: 340 LPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSF-EAGIRVQIHSQEEPPYIHQLGFGV 398
+ G GL ++ ++ QE + + F +AGI IHS ++ P LG
Sbjct: 218 AKRKVSVSGRGLSLLFNVNQEAF----TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLS 273
Query: 399 SPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRC 458
G V+ ++ + + PWG C +LQ +S+YS S C C+ + + ++C
Sbjct: 274 PVGMHARVTIRQVKTVHQEYPWGECNPNI-----KLQNFSSYSTSGCLKECKAQHIKKQC 328
Query: 459 HCRMVHMPDSLGGGPE----------GPCF-----------------CPTPCNLTRYGKE 491
C +P G G E P CP C Y
Sbjct: 329 GCVPFLLP---GYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPAT 385
Query: 492 ISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDL 551
IS P++ + +YL++K N++ YIREN + +++ + L + +Q+ A +S LL DL
Sbjct: 386 ISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADL 445
Query: 552 GGQMGLFIGASILTLLEILDYIY 574
GGQ+GLF GAS++T++EI++Y++
Sbjct: 446 GGQLGLFCGASLITIIEIIEYLF 468
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 126 bits (317), Expect = 5e-29
Identities = 102/384 (26%), Positives = 169/384 (44%), Gaps = 72/384 (18%)
Query: 241 AVTLCNINR----FRH-----SALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVD 291
A+ LC++NR FR+ AL++ I N+ + P+ ++V+
Sbjct: 192 AMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFA--------------QVPQQELVE 237
Query: 292 ILNRTGHQLADMLKSCNFSGHHCSASNF-SVVYTRYGKCYTFN-ADPRSSLPSRAGGMGS 349
++ G Q M+ +C F C+ NF S+ Y YG CY FN +LPS G
Sbjct: 238 -MSYPGEQ---MILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEF 293
Query: 350 GLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ 409
GL+++LDI QE+Y+P T AG+R+ +H Q P+I G G +T +
Sbjct: 294 GLKLILDIGQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVL 347
Query: 410 EQRLTYLPQPWGNCRAESELREPELQGY-----SAYSVSACRLRCEKEAVLQRCHCRMVH 464
+L + +P+ C E +Q + + YS+ AC C ++ +++ C+C
Sbjct: 348 VDKLQRMGEPYSPCTVNGS--EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL 405
Query: 465 MPDSLG----GGPEGP----CF----------------CPTPCNLTRYGKEISMVRIPNR 500
P G + P C+ C CN T+Y ISM P+
Sbjct: 406 YPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465
Query: 501 GSARYL------ARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQ 554
S ++ R + N T R+ + L+++F+ +E+ AA + LL +LGGQ
Sbjct: 466 ASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQ 525
Query: 555 MGLFIGASILTLLEILDYIYEVSW 578
G ++G S+L L+E + I + W
Sbjct: 526 FGFWMGGSVLCLIEFGEIIIDFVW 549
Score = 35.8 bits (81), Expect = 0.13
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 5/95 (5%)
Query: 162 PGAAPRDLAT-FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYL 220
PG ++L + + HG R GP ++ +W L L A +Q R YL
Sbjct: 18 PGYTYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYL 75
Query: 221 TRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSAL 255
+ V++ + FPAVT+CN + F++S +
Sbjct: 76 SWE--VSVSLSVGFKTMDFPAVTICNASPFKYSKI 108
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 126 bits (316), Expect = 7e-29
Identities = 147/599 (24%), Positives = 237/599 (39%), Gaps = 133/599 (22%)
Query: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203
P KE E G V A+ R+L TF T+ T+HG R + L+ T W L L
Sbjct: 39 PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 94
Query: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242
+L A +Q L + RP L+A+ +P P+PV +
Sbjct: 95 ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 154
Query: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278
+L N+N + A A + FHL L G R
Sbjct: 155 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 214
Query: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318
AA + VDIL + G Q + SC++ G C A
Sbjct: 215 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 274
Query: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377
F + YG CYT + + P G+ G+ ++L ++Q+ +LP+ S AG
Sbjct: 275 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 324
Query: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437
IRV +H + P++ F V PG + +S +E + L P+G+C A E E EL
Sbjct: 325 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 384
Query: 438 SAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPE----------GPCF--------- 478
++Y+ AC + C ++ +++ C C P L G E G CF
Sbjct: 385 TSYTRQACLVSCFQQLMVETCSCGYYLHP--LPAGAEYCSSARHPAWGHCFYRLYQDLET 442
Query: 479 --------CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRENFLV-LD 525
CP PC + + R P+ SA + L + ++++ + + L ++
Sbjct: 443 HRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKIN 502
Query: 526 VFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS-------W 578
+ ++ L ++E+ Y + LL +G L+ GAS+L+LLE+L+ + + S
Sbjct: 503 IVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGG 562
Query: 579 DRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGP 637
RL+R W P + G S+ ++ Q P P+ G ++ P PH P
Sbjct: 563 RRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEPSGPHLP 610
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 126 bits (316), Expect = 7e-29
Identities = 147/599 (24%), Positives = 237/599 (39%), Gaps = 133/599 (22%)
Query: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203
P KE E G V A+ R+L TF T+ T+HG R + L+ T W L L
Sbjct: 105 PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 160
Query: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242
+L A +Q L + RP L+A+ +P P+PV +
Sbjct: 161 ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 220
Query: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278
+L N+N + A A + FHL L G R
Sbjct: 221 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 280
Query: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318
AA + VDIL + G Q + SC++ G C A
Sbjct: 281 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 340
Query: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377
F + YG CYT + + P G+ G+ ++L ++Q+ +LP+ S AG
Sbjct: 341 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 390
Query: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437
IRV +H + P++ F V PG + +S +E + L P+G+C A E E EL
Sbjct: 391 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 450
Query: 438 SAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPE----------GPCF--------- 478
++Y+ AC + C ++ +++ C C P L G E G CF
Sbjct: 451 TSYTRQACLVSCFQQLMVETCSCGYYLHP--LPAGAEYCSSARHPAWGHCFYRLYQDLET 508
Query: 479 --------CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRENFLV-LD 525
CP PC + + R P+ SA + L + ++++ + + L ++
Sbjct: 509 HRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKIN 568
Query: 526 VFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS-------W 578
+ ++ L ++E+ Y + LL +G L+ GAS+L+LLE+L+ + + S
Sbjct: 569 IVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGG 628
Query: 579 DRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGP 637
RL+R W P + G S+ ++ Q P P+ G ++ P PH P
Sbjct: 629 RRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEPSGPHLP 676
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 117 bits (294), Expect = 3e-26
Identities = 77/308 (25%), Positives = 142/308 (46%), Gaps = 37/308 (12%)
Query: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
L + + +C F+ C+ +N+S + YG CYTFN S+L S G+ +GL +ML
Sbjct: 334 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 393
Query: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
+Q +++P+ S G RV +H Q+EP ++ GF + PG +T +S +++ L L
Sbjct: 394 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 447
Query: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP--------DSL 469
+G+C E S Y+ C C +E++++ C C + P D
Sbjct: 448 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 507
Query: 470 GGGPEGPCF-----------------CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNR 512
G C+ C PC++T Y R P+ S ++ + +R
Sbjct: 508 KHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSR 567
Query: 513 NETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLE 568
Y R +++FF+ L + + + + LL +LG Q L+ G+S+L+++E
Sbjct: 568 QNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 627
Query: 569 ILDYIYEV 576
+ + ++++
Sbjct: 628 MAELVFDL 635
Score = 41.2 bits (95), Expect = 0.003
Identities = 49/201 (24%), Positives = 80/201 (39%), Gaps = 18/201 (8%)
Query: 66 GAAGSGSDSPT-------SGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREA 118
G G G+ P P P L LEEQ P PL PGL+ +
Sbjct: 13 GVMGEGTQGPELSLDPDPCSPQSTPGLMK-GNKLEEQD--PRPLQPIPGLMEGNKLEEQD 69
Query: 119 LASPSSR-GQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATF-ASTS 176
+ P S G M + E A P++ A +E + + R+L F + +
Sbjct: 70 SSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEE----ALIEFHRSYRELFEFFCNNT 125
Query: 177 TLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPV 236
T+HG R + ++ WA+ L + +Q L Y + P V+++ +
Sbjct: 126 TIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNINLNSDK 183
Query: 237 AGFPAVTLCNINRFRHSALSD 257
FPAVT+C +N +R+ + +
Sbjct: 184 LVFPAVTICTLNPYRYPEIKE 204
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 117 bits (294), Expect = 3e-26
Identities = 77/308 (25%), Positives = 142/308 (46%), Gaps = 37/308 (12%)
Query: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
L + + +C F+ C+ +N+S + YG CYTFN S+L S G+ +GL +ML
Sbjct: 298 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 357
Query: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
+Q +++P+ S G RV +H Q+EP ++ GF + PG +T +S +++ L L
Sbjct: 358 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 411
Query: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP--------DSL 469
+G+C E S Y+ C C +E++++ C C + P D
Sbjct: 412 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 471
Query: 470 GGGPEGPCF-----------------CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNR 512
G C+ C PC++T Y R P+ S ++ + +R
Sbjct: 472 KHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSR 531
Query: 513 NETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLE 568
Y R +++FF+ L + + + + LL +LG Q L+ G+S+L+++E
Sbjct: 532 QNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 591
Query: 569 ILDYIYEV 576
+ + ++++
Sbjct: 592 MAELVFDL 599
Score = 40.0 bits (92), Expect = 0.007
Identities = 42/168 (25%), Positives = 72/168 (42%), Gaps = 10/168 (5%)
Query: 92 LEEQPLPPLPLGRAPGLLAREGQGREALASPSSR-GQMPIEIVCKIKFAEEDAKPKEKEA 150
LEEQ P PL PGL+ + + P S G M + E A P++ A
Sbjct: 9 LEEQD--PRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTA 66
Query: 151 GDEQSLLGAVAPGAAPRDLATF-ASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFL 209
+E + + R+L F + +T+HG R + ++ WA+ L +
Sbjct: 67 EEE----ALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMY 122
Query: 210 YQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSD 257
+Q L Y + P V+++ + FPAVT+C +N +R+ + +
Sbjct: 123 WQFGLLFGEYFSYP--VSLNINLNSDKLVFPAVTICTLNPYRYPEIKE 168
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 117 bits (294), Expect = 3e-26
Identities = 77/308 (25%), Positives = 142/308 (46%), Gaps = 37/308 (12%)
Query: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
L + + +C F+ C+ +N+S + YG CYTFN S+L S G+ +GL +ML
Sbjct: 275 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 334
Query: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
+Q +++P+ S G RV +H Q+EP ++ GF + PG +T +S +++ L L
Sbjct: 335 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 388
Query: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP--------DSL 469
+G+C E S Y+ C C +E++++ C C + P D
Sbjct: 389 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 448
Query: 470 GGGPEGPCF-----------------CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNR 512
G C+ C PC++T Y R P+ S ++ + +R
Sbjct: 449 KHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSR 508
Query: 513 NETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLE 568
Y R +++FF+ L + + + + LL +LG Q L+ G+S+L+++E
Sbjct: 509 QNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVE 568
Query: 569 ILDYIYEV 576
+ + ++++
Sbjct: 569 MAELVFDL 576
Score = 37.0 bits (84), Expect = 0.057
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
F + +T+HG R + ++ WA+ L + +Q L Y + P V+++
Sbjct: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNIN 119
Query: 232 APAPVAGFPAVTLCNINRFRHSALSD 257
+ FPAVT+C +N +R+ + +
Sbjct: 120 LNSDKLVFPAVTICTLNPYRYPEIKE 145
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 92.8 bits (229), Expect = 9e-19
Identities = 72/331 (21%), Positives = 138/331 (41%), Gaps = 47/331 (14%)
Query: 302 DMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFN-ADPRSSLPSRAGGMGSGLEIMLDIQQ 359
++L +C F G C A NF++ + +G CYTFN + + L + GG GL+++L I +
Sbjct: 255 ELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINE 314
Query: 360 EEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQP 419
EEY P + G +V IH Q+E P++ +G + T + L +P
Sbjct: 315 EEYNPFLVSST------GAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEP 368
Query: 420 WGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP----DSLGGGPEG 475
+ C + +AYS+ C C + ++++C C P + +
Sbjct: 369 YSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQH 428
Query: 476 P----CF-----------------CPTPCNLTRYGKEISMVRIPNRGSARYLA------R 508
P C+ C C+ + S+ + P+ S ++L +
Sbjct: 429 PNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQ 488
Query: 509 KYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLE 568
N+ + + L +F++ L ++ + A + LL + GGQ+GL++ S++ ++E
Sbjct: 489 GRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIE 548
Query: 569 ILDYIY--------EVSWDRLKRVWRRPKTP 591
I++ + W + K W + P
Sbjct: 549 IIEVFFIDFFSIIARRQWQKAKEWWAWKQAP 579
Score = 40.4 bits (93), Expect = 0.005
Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Query: 192 LRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFR 251
LRR LW LT++A L+Q A L + T V++ FPAVT+CNIN ++
Sbjct: 51 LRRLLWIGFTLTAVALILWQCALLVFSFYT----VSVSIKVHFRKLDFPAVTICNINPYK 106
Query: 252 HSAL 255
+S +
Sbjct: 107 YSTV 110
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 40.8 bits (94), Expect = 0.004
Identities = 35/132 (26%), Positives = 52/132 (39%), Gaps = 12/132 (9%)
Query: 47 EERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQ-PLPPLPLGRA 105
EE +K ++R +R Q Q A+ +P + P + P +EE PLPP L +
Sbjct: 943 EEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTS 1002
Query: 106 PGLLAREGQGREALASPSSRGQMPIEIVC---------KIKFAEEDAKPKEKEAGDEQSL 156
R+G S G +P E+ C E P ++ E+SL
Sbjct: 1003 QDGHRRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESL 1062
Query: 157 LGAVAPGAAPRD 168
A +P AA D
Sbjct: 1063 --AASPMAAKPD 1072
>gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 6 [Homo sapiens]
Length = 1093
Score = 40.0 bits (92), Expect = 0.007
Identities = 26/55 (47%), Positives = 29/55 (52%), Gaps = 9/55 (16%)
Query: 62 HQGCGAAGSGSDSPTSGPHPVPVL------FPLALSLEEQPLPPLP---LGRAPG 107
H GC + S S S S P P+P+L PLAL PLPP P LGRAPG
Sbjct: 817 HSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPAPLPPQPQNGLGRAPG 871
>gi|30425428 deltex homolog 3 [Homo sapiens]
Length = 347
Score = 38.9 bits (89), Expect = 0.015
Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 43 KETIEERDKRQQRQQRQRQHQGCGAAGSGSDSP---TSGPHPV---PVLFPLALSLEEQP 96
K ++E +K ++ QRQ + GC A G G + P +GP P+ P+L P A L P
Sbjct: 83 KGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPP 142
Query: 97 LPPLPLGRAPGLLAREGQGREALASPSSRGQM 128
PPLP P L RE + P G++
Sbjct: 143 -PPLPPPLPPRL--REEAEEQESTCPICLGEI 171
>gi|90193619 nuclear matrix transcription factor 4 isoform c [Homo
sapiens]
Length = 461
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 8 AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
AA A A + ++ A A A + A A + S ++ +++ ++QQ+QQ Q GA
Sbjct: 351 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 410
Query: 68 AGSGSDSPTSGPHPVP 83
A G S P+P P
Sbjct: 411 APQGGGGGDSNPNPPP 426
>gi|90193617 nuclear matrix transcription factor 4 isoform b [Homo
sapiens]
Length = 500
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 8 AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
AA A A + ++ A A A + A A + S ++ +++ ++QQ+QQ Q GA
Sbjct: 390 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 449
Query: 68 AGSGSDSPTSGPHPVP 83
A G S P+P P
Sbjct: 450 APQGGGGGDSNPNPPP 465
>gi|90193615 nuclear matrix transcription factor 4 isoform b [Homo
sapiens]
Length = 500
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 8 AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
AA A A + ++ A A A + A A + S ++ +++ ++QQ+QQ Q GA
Sbjct: 390 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 449
Query: 68 AGSGSDSPTSGPHPVP 83
A G S P+P P
Sbjct: 450 APQGGGGGDSNPNPPP 465
>gi|90193613 nuclear matrix transcription factor 4 isoform a [Homo
sapiens]
Length = 516
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 8 AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
AA A A + ++ A A A + A A + S ++ +++ ++QQ+QQ Q GA
Sbjct: 406 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 465
Query: 68 AGSGSDSPTSGPHPVP 83
A G S P+P P
Sbjct: 466 APQGGGGGDSNPNPPP 481
>gi|90193611 nuclear matrix transcription factor 4 isoform a [Homo
sapiens]
Length = 516
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 8 AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
AA A A + ++ A A A + A A + S ++ +++ ++QQ+QQ Q GA
Sbjct: 406 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 465
Query: 68 AGSGSDSPTSGPHPVP 83
A G S P+P P
Sbjct: 466 APQGGGGGDSNPNPPP 481
>gi|36054194 nuclear matrix transcription factor 4 isoform a [Homo
sapiens]
Length = 516
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 8 AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
AA A A + ++ A A A + A A + S ++ +++ ++QQ+QQ Q GA
Sbjct: 406 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 465
Query: 68 AGSGSDSPTSGPHPVP 83
A G S P+P P
Sbjct: 466 APQGGGGGDSNPNPPP 481
>gi|209180475 nuclear matrix transcription factor 4 isoform d [Homo
sapiens]
Length = 577
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 8 AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
AA A A + ++ A A A + A A + S ++ +++ ++QQ+QQ Q GA
Sbjct: 467 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 526
Query: 68 AGSGSDSPTSGPHPVP 83
A G S P+P P
Sbjct: 527 APQGGGGGDSNPNPPP 542
>gi|40354197 THAP domain containing 11 [Homo sapiens]
Length = 314
Score = 38.5 bits (88), Expect = 0.019
Identities = 32/145 (22%), Positives = 65/145 (44%), Gaps = 8/145 (5%)
Query: 22 RSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHP 81
R +A AGA + + ++ +++ ++QQ+QQ+Q+Q Q ++ S S + T+ P
Sbjct: 88 RKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQP 147
Query: 82 VPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALASPSSRGQMPIEIVCKIKFAEE 141
V A+ L Q + +APG + + A +P+ PI++ +++FA
Sbjct: 148 NLVSASAAVLLTLQ--ATVDSSQAPGSV------QPAPITPTGEDVKPIDLTVQVEFAAA 199
Query: 142 DAKPKEKEAGDEQSLLGAVAPGAAP 166
+ A + Q+ + P
Sbjct: 200 EGAAAAAAASELQAATAGLEAAECP 224
>gi|55750053 atrophin-1 [Homo sapiens]
Length = 1190
Score = 38.5 bits (88), Expect = 0.019
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 30 GADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHPVP-----V 84
GA S A +H +++ ++QQ+QQ+Q+Q Q SG P + PHP+
Sbjct: 467 GAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHH 526
Query: 85 LFPLALSLEEQPLPPLPLGRA 105
P A+S L P P G A
Sbjct: 527 AHPYAMSPSLGSLRPYPPGPA 547
>gi|55750041 atrophin-1 [Homo sapiens]
Length = 1190
Score = 38.5 bits (88), Expect = 0.019
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 30 GADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHPVP-----V 84
GA S A +H +++ ++QQ+QQ+Q+Q Q SG P + PHP+
Sbjct: 467 GAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHH 526
Query: 85 LFPLALSLEEQPLPPLPLGRA 105
P A+S L P P G A
Sbjct: 527 AHPYAMSPSLGSLRPYPPGPA 547
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,593,004
Number of Sequences: 37866
Number of extensions: 1588599
Number of successful extensions: 7514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 7023
Number of HSP's gapped (non-prelim): 420
length of query: 647
length of database: 18,247,518
effective HSP length: 109
effective length of query: 538
effective length of database: 14,120,124
effective search space: 7596626712
effective search space used: 7596626712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.