Guide to the Human Genome
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Search of human proteins with 33519442

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33519442 amiloride-sensitive cation channel 4 isoform 1
[Homo sapiens]
         (666 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo...  1370   0.0  
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo...  1316   0.0  
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo...   488   e-137
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo...   466   e-131
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ...   447   e-125
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ...   447   e-125
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor...   446   e-125
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ...   443   e-124
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo...   417   e-116
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho...   191   2e-48
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi...   134   2e-31
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ...   127   3e-29
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1...   127   3e-29
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ...   122   8e-28
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ...   122   8e-28
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H...   122   8e-28
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi...    97   6e-20
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]           41   0.004
gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithora...    40   0.007
gi|30425428 deltex homolog 3 [Homo sapiens]                            39   0.015
gi|90193619 nuclear matrix transcription factor 4 isoform c [Hom...    39   0.020
gi|90193617 nuclear matrix transcription factor 4 isoform b [Hom...    39   0.020
gi|90193615 nuclear matrix transcription factor 4 isoform b [Hom...    39   0.020
gi|90193613 nuclear matrix transcription factor 4 isoform a [Hom...    39   0.020
gi|90193611 nuclear matrix transcription factor 4 isoform a [Hom...    39   0.020
gi|36054194 nuclear matrix transcription factor 4 isoform a [Hom...    39   0.020
gi|209180475 nuclear matrix transcription factor 4 isoform d [Ho...    39   0.020
gi|40354197 THAP domain containing 11 [Homo sapiens]                   39   0.020
gi|55750053 atrophin-1 [Homo sapiens]                                  39   0.020
gi|55750041 atrophin-1 [Homo sapiens]                                  39   0.020

>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
           sapiens]
          Length = 666

 Score = 1370 bits (3546), Expect = 0.0
 Identities = 666/666 (100%), Positives = 666/666 (100%)

Query: 1   MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60
           MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR
Sbjct: 1   MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60

Query: 61  QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120
           QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA
Sbjct: 61  QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120

Query: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180
           SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG
Sbjct: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180

Query: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240
           LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP
Sbjct: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240

Query: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300
           AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL
Sbjct: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300

Query: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360
           ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE
Sbjct: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360

Query: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
           EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW
Sbjct: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420

Query: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC 480
           GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC
Sbjct: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC 480

Query: 481 ADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 540
           ADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF
Sbjct: 481 ADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 540

Query: 541 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600
           LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL
Sbjct: 541 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600

Query: 601 KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL 660
           KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL
Sbjct: 601 KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL 660

Query: 661 FEDFAC 666
           FEDFAC
Sbjct: 661 FEDFAC 666


>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
           sapiens]
          Length = 647

 Score = 1316 bits (3405), Expect = 0.0
 Identities = 647/666 (97%), Positives = 647/666 (97%), Gaps = 19/666 (2%)

Query: 1   MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60
           MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR
Sbjct: 1   MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQR 60

Query: 61  QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120
           QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA
Sbjct: 61  QHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALA 120

Query: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180
           SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG
Sbjct: 121 SPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHG 180

Query: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240
           LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP
Sbjct: 181 LGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFP 240

Query: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300
           AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL
Sbjct: 241 AVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQL 300

Query: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360
           ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE
Sbjct: 301 ADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQE 360

Query: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
           EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW
Sbjct: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420

Query: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC 480
           GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP              
Sbjct: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP-------------- 466

Query: 481 ADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 540
                DSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF
Sbjct: 467 -----DSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 521

Query: 541 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600
           LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL
Sbjct: 522 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 581

Query: 601 KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL 660
           KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL
Sbjct: 582 KRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNHHHPHGPPGGL 641

Query: 661 FEDFAC 666
           FEDFAC
Sbjct: 642 FEDFAC 647


>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
           b [Homo sapiens]
          Length = 528

 Score =  488 bits (1255), Expect = e-137
 Identities = 263/547 (48%), Positives = 342/547 (62%), Gaps = 42/547 (7%)

Query: 142 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL 201
           + K +E+E G           G  P  +  FAS+STLHGL          L+R LWAL  
Sbjct: 2   ELKAEEEEVG-----------GVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF 50

Query: 202 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF 261
           L SLA  L       + Y    H+  +D  A + +  FPAVTLCN+N FR S +S  D++
Sbjct: 51  LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRFSQVSKNDLY 109

Query: 262 HLANLTGL-------PPKDRDGHRAAGLRY---------PEP-DMVDILNRTGHQLADML 304
           H   L  L       P       +   +           P+P +M +  +R GH + DML
Sbjct: 110 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDML 169

Query: 305 KSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEY 362
            SC+F G  CSA +F VV+TRYGKCYTFN+  D R  L +  GG G+GLEIMLDIQQ+EY
Sbjct: 170 LSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEY 229

Query: 363 LPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGN 422
           LP+W ET+ETSFEAGI+VQIHSQ+EPP+I QLGFGV+PGFQTFV+CQEQRL YLP PWG 
Sbjct: 230 LPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 289

Query: 423 CRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECAD 482
           C+A +   + +L  + +YS++ACR+ CE   +++ C+CRMVHMPG+   C P  Y ECAD
Sbjct: 290 CKAVT--MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECAD 347

Query: 483 HTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLV 542
             LD L    +  C C  PCNLTRYGKE+SMV+IP++ SA+YLA+K+N++E YI EN LV
Sbjct: 348 PALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILV 407

Query: 543 LDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKR 602
           LD+FFE L  E +EQ+ AY ++ LLGD+GGQMGLFIGASILT+LE+ DY YEV   +L R
Sbjct: 408 LDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCR 467

Query: 603 VWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGV---SSLLPNHHHPHGPPGG 659
             +  K   R+S      L L ++K  +PC SL R    G+   +++LP+H     P  G
Sbjct: 468 RGKCQKEAKRSSADKGVALSLDDVKRHNPCESL-RGHPAGMTYAANILPHH-----PARG 521

Query: 660 LFEDFAC 666
            FEDF C
Sbjct: 522 TFEDFTC 528


>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
           a [Homo sapiens]
          Length = 574

 Score =  466 bits (1198), Expect = e-131
 Identities = 263/593 (44%), Positives = 342/593 (57%), Gaps = 88/593 (14%)

Query: 142 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL 201
           + K +E+E G           G  P  +  FAS+STLHGL          L+R LWAL  
Sbjct: 2   ELKAEEEEVG-----------GVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF 50

Query: 202 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF 261
           L SLA  L       + Y    H+  +D  A + +  FPAVTLCN+N FR S +S  D++
Sbjct: 51  LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRFSQVSKNDLY 109

Query: 262 HLANLTGL-------PPKDRDGHRAAGLRY---------PEP-DMVDILNRTGHQLADML 304
           H   L  L       P       +   +           P+P +M +  +R GH + DML
Sbjct: 110 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDML 169

Query: 305 KSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEY 362
            SC+F G  CSA +F VV+TRYGKCYTFN+  D R  L +  GG G+GLEIMLDIQQ+EY
Sbjct: 170 LSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEY 229

Query: 363 LPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGN 422
           LP+W ET+ETSFEAGI+VQIHSQ+EPP+I QLGFGV+PGFQTFV+CQEQRL YLP PWG 
Sbjct: 230 LPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 289

Query: 423 CRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECAD 482
           C+A +   + +L  + +YS++ACR+ CE   +++ C+CRMVHMPG+   C P  Y ECAD
Sbjct: 290 CKAVT--MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECAD 347

Query: 483 HTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLV 542
             LD L    +  C C  PCNLTRYGKE+SMV+IP++ SA+YLA+K+N++E YI EN LV
Sbjct: 348 PALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILV 407

Query: 543 LDVFFEALTSEAMEQRAAYGLSAL------------------------------------ 566
           LD+FFE L  E +EQ+ AY ++ L                                    
Sbjct: 408 LDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPP 467

Query: 567 ----------LGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTG 616
                     LGD+GGQMGLFIGASILT+LE+ DY YEV   +L R  +  K   R+S  
Sbjct: 468 PQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSAD 527

Query: 617 GISTLGLQELKEQSPCPSLGRAEGGGV---SSLLPNHHHPHGPPGGLFEDFAC 666
               L L ++K  +PC SL R    G+   +++LP+H     P  G FEDF C
Sbjct: 528 KGVALSLDDVKRHNPCESL-RGHPAGMTYAANILPHH-----PARGTFEDFTC 574


>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
           sapiens]
          Length = 531

 Score =  447 bits (1149), Expect = e-125
 Identities = 244/493 (49%), Positives = 303/493 (61%), Gaps = 28/493 (5%)

Query: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227
           D+  FAS  ++HGLG   GPG   LRR +WA A++ S+A FLYQ A   R Y    H  A
Sbjct: 16  DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75

Query: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286
           +D      +  FPAVTLCNIN  R S L+  D+    + L GL P +      A  R P 
Sbjct: 76  LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134

Query: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335
           P         DM  +  R GH L DML  C F G  C   NF+ ++TR GKCYTFN  AD
Sbjct: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194

Query: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395
               L +  GGMG+GL+IMLD+QQEEYLP+WR+  ET FE GIRVQIHSQEEPP I QLG
Sbjct: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254

Query: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444
            GVSPG+QTFVSCQ+Q+L++LP PWG+C + S            L  P       Y++  
Sbjct: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314

Query: 445 CRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNL 504
           CRL CE   V ++C CRMV+MPG+  +C P  Y  CA   +D++    +  C CP PC  
Sbjct: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR--KDSCACPNPCAS 372

Query: 505 TRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLS 564
           TRY KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL  E +EQ+ AY +S
Sbjct: 373 TRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMS 432

Query: 565 ALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTSTGGISTLGL 623
            LLGD+GGQMGLFIGAS+LT+LEILDY+ EV  D+ L   W R  +   +ST  +   GL
Sbjct: 433 ELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQE-GL 491

Query: 624 QELKEQSPCPSLG 636
              + Q P  SLG
Sbjct: 492 GSHRTQVPHLSLG 504


>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
           sapiens]
          Length = 549

 Score =  447 bits (1149), Expect = e-125
 Identities = 244/493 (49%), Positives = 303/493 (61%), Gaps = 28/493 (5%)

Query: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227
           D+  FAS  ++HGLG   GPG   LRR +WA A++ S+A FLYQ A   R Y    H  A
Sbjct: 16  DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75

Query: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286
           +D      +  FPAVTLCNIN  R S L+  D+    + L GL P +      A  R P 
Sbjct: 76  LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134

Query: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335
           P         DM  +  R GH L DML  C F G  C   NF+ ++TR GKCYTFN  AD
Sbjct: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194

Query: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395
               L +  GGMG+GL+IMLD+QQEEYLP+WR+  ET FE GIRVQIHSQEEPP I QLG
Sbjct: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254

Query: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444
            GVSPG+QTFVSCQ+Q+L++LP PWG+C + S            L  P       Y++  
Sbjct: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314

Query: 445 CRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNL 504
           CRL CE   V ++C CRMV+MPG+  +C P  Y  CA   +D++    +  C CP PC  
Sbjct: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR--KDSCACPNPCAS 372

Query: 505 TRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLS 564
           TRY KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL  E +EQ+ AY +S
Sbjct: 373 TRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMS 432

Query: 565 ALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTSTGGISTLGL 623
            LLGD+GGQMGLFIGAS+LT+LEILDY+ EV  D+ L   W R  +   +ST  +   GL
Sbjct: 433 ELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQE-GL 491

Query: 624 QELKEQSPCPSLG 636
              + Q P  SLG
Sbjct: 492 GSHRTQVPHLSLG 504


>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
           [Homo sapiens]
          Length = 512

 Score =  446 bits (1148), Expect = e-125
 Identities = 226/454 (49%), Positives = 299/454 (65%), Gaps = 24/454 (5%)

Query: 166 PRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHL 225
           P  +  FA+TSTLHG+      GP  +RR LWA+A + SL   L +++     Y +  H+
Sbjct: 14  PSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHV 73

Query: 226 VAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDR---DGHRA--- 279
             +D      +  FPAVTLCN+N FR S L+  D++H   L  L   +    D H A   
Sbjct: 74  TKVDEVVAQSLV-FPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPS 132

Query: 280 --------AGLRYPEP---DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGK 328
                   A  ++ +P    M++ L+R GH L DM+  C F G  C   +F+ V+T+YGK
Sbjct: 133 VLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGK 192

Query: 329 CYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQE 386
           CY FN+  D +  L +  GG G+GLEIMLDIQQ+EYLPIW ET ET+FEAG++VQIHSQ 
Sbjct: 193 CYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQS 252

Query: 387 EPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACR 446
           EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PWG CR+     E  L  +  YS++ACR
Sbjct: 253 EPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSS----EMGLDFFPVYSITACR 308

Query: 447 LRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNLTR 506
           + CE   +++ C+CRMVHMPG+   C P  + ECA+  L  L       C C TPCNLTR
Sbjct: 309 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 368

Query: 507 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 566
           Y KE+SMV+IP++ SA+YL +K+N++E YI EN LVLD+FFEAL  E +EQ+ AY ++AL
Sbjct: 369 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428

Query: 567 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600
           LGD+GGQMGLFIGASILT+LE+ DYIYE+  ++L
Sbjct: 429 LGDIGGQMGLFIGASILTILELFDYIYELIKEKL 462


>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
           sapiens]
          Length = 543

 Score =  443 bits (1140), Expect = e-124
 Identities = 237/472 (50%), Positives = 294/472 (62%), Gaps = 27/472 (5%)

Query: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227
           D+  FAS  ++HGLG   GPG   LRR +WA A++ S+A FLYQ A   R Y    H  A
Sbjct: 16  DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75

Query: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286
           +D      +  FPAVTLCNIN  R S L+  D+    + L GL P +      A  R P 
Sbjct: 76  LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134

Query: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335
           P         DM  +  R GH L DML  C F G  C   NF+ ++TR GKCYTFN  AD
Sbjct: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194

Query: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395
               L +  GGMG+GL+IMLD+QQEEYLP+WR+  ET FE GIRVQIHSQEEPP I QLG
Sbjct: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254

Query: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444
            GVSPG+QTFVSCQ+Q+L++LP PWG+C + S            L  P       Y++  
Sbjct: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314

Query: 445 CRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNL 504
           CRL CE   V ++C CRMV+MPG+  +C P  Y  CA   +D++    +  C CP PC  
Sbjct: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR--KDSCACPNPCAS 372

Query: 505 TRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLS 564
           TRY KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL  E +EQ+ AY +S
Sbjct: 373 TRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMS 432

Query: 565 ALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTST 615
            LLGD+GGQMGLFIGAS+LT+LEILDY+ EV  D+ L   W R  +   +ST
Sbjct: 433 ELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSST 484


>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
           1 [Homo sapiens]
          Length = 563

 Score =  417 bits (1071), Expect = e-116
 Identities = 229/480 (47%), Positives = 295/480 (61%), Gaps = 39/480 (8%)

Query: 151 GDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACG----PGPHGLRRTLWALALLTSLA 206
           G E++L G   PG A R   +  S + LHGL   C      G    RR LW LA  TS  
Sbjct: 43  GGERALQG---PGVARRGRPSL-SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFG 98

Query: 207 AFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANL 266
             L  ++     +L+ P    +       +  FPAVT+CN N  R   LS  D+++  + 
Sbjct: 99  LLLSWSSNRLLYWLSFPSHTRVHREWSRQLP-FPAVTVCNNNPLRFPRLSKGDLYYAGHW 157

Query: 267 TGLPPKDRDGHRAAG--LRYPEP------DMVD----------------ILNRTGHQLAD 302
            GL   +R         LR  EP       + D                 ++R GHQL D
Sbjct: 158 LGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLED 217

Query: 303 MLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQE 360
           ML SC + G  C   NFS V+T+YGKCY FN+  D +  L +  GG G+GLEIMLDIQQ+
Sbjct: 218 MLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 277

Query: 361 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPW 420
           EYLPIW ET ET+FEAG++VQIHSQ EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PW
Sbjct: 278 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 337

Query: 421 GNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC 480
           G CR+     E  L  +  YS++ACR+ CE   +++ C+CRMVHMPG+   C P  + EC
Sbjct: 338 GECRSS----EMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKEC 393

Query: 481 ADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 540
           A+  L  L       C C TPCNLTRY KE+SMV+IP++ SA+YL +K+N++E YI EN 
Sbjct: 394 AEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENI 453

Query: 541 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600
           LVLD+FFEAL  E +EQ+ AY ++ALLGD+GGQMGLFIGASILT+LE+ DYIYE+  ++L
Sbjct: 454 LVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKL 513


>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
           sapiens]
          Length = 505

 Score =  191 bits (485), Expect = 2e-48
 Identities = 124/441 (28%), Positives = 206/441 (46%), Gaps = 32/441 (7%)

Query: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
           FA +++ HG+          +RR LW + +L S++   +Q       Y T P   +++  
Sbjct: 41  FAISTSFHGIHNIV-QNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99

Query: 232 APAPVAGFPAVTLCNINRFRHSALSD-----------ADIFHLANLTGLPPKDRDGHRAA 280
               +  FPAVT CN+NRF+  A++            + + HL  +T      R+    A
Sbjct: 100 YVEKME-FPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFA 158

Query: 281 GLRYPEPDMVDILNRTGHQLADM-LKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSS 339
              +    +V+ +   G  L +  L  C F G  CS  +F+ V+T YG C+TFN      
Sbjct: 159 A-SHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQ 217

Query: 340 LPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSF-EAGIRVQIHSQEEPPYIHQLGFGV 398
              +    G GL ++ ++ QE +     +     F +AGI   IHS ++ P    LG   
Sbjct: 218 AKRKVSVSGRGLSLLFNVNQEAFT----DNPALGFVDAGIIFVIHSPKKVPQFDGLGLLS 273

Query: 399 SPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRC 458
             G    V+ ++ +  +   PWG C    +L     Q +S+YS S C   C+ + + ++C
Sbjct: 274 PVGMHARVTIRQVKTVHQEYPWGECNPNIKL-----QNFSSYSTSGCLKECKAQHIKKQC 328

Query: 459 HCRMVHMPGNETICPPNIYIECADHTLDSLGG------GPEGPCFCPTPCNLTRYGKEIS 512
            C    +PG    C    Y  C    LD +        G      CP  C    Y   IS
Sbjct: 329 GCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSS-CPVSCEEIEYPATIS 387

Query: 513 MVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGG 572
               P++ + +YL++K N++  YIREN + +++ +  L  +  +Q+ A  +S LL DLGG
Sbjct: 388 YSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGG 447

Query: 573 QMGLFIGASILTLLEILDYIY 593
           Q+GLF GAS++T++EI++Y++
Sbjct: 448 QLGLFCGASLITIIEIIEYLF 468


>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
           sapiens]
          Length = 640

 Score =  134 bits (338), Expect = 2e-31
 Identities = 104/384 (27%), Positives = 174/384 (45%), Gaps = 53/384 (13%)

Query: 241 AVTLCNINR----FRH-----SALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVD 291
           A+ LC++NR    FR+      AL++  I    N+                + P+ ++V+
Sbjct: 192 AMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFA--------------QVPQQELVE 237

Query: 292 ILNRTGHQLADMLKSCNFSGHHCSASNF-SVVYTRYGKCYTFN-ADPRSSLPSRAGGMGS 349
            ++  G Q   M+ +C F    C+  NF S+ Y  YG CY FN      +LPS   G   
Sbjct: 238 -MSYPGEQ---MILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEF 293

Query: 350 GLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ 409
           GL+++LDI QE+Y+P    T      AG+R+ +H Q   P+I   G     G +T +   
Sbjct: 294 GLKLILDIGQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVL 347

Query: 410 EQRLTYLPQPWGNCRAESELREPELQGY-----SAYSVSACRLRCEKEAVLQRCHCR--M 462
             +L  + +P+  C       E  +Q +     + YS+ AC   C ++ +++ C+C   +
Sbjct: 348 VDKLQRMGEPYSPCTVNGS--EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL 405

Query: 463 VHMPGNETICPPNIYIECADHTLD-SLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNR 519
             +P  E  C    + + A    D  +       C   C   CN T+Y   ISM   P+ 
Sbjct: 406 YPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465

Query: 520 GSARYL------ARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQ 573
            S  ++       R  + N T  R+  + L+++F+      +E+ AA  +  LL +LGGQ
Sbjct: 466 ASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQ 525

Query: 574 MGLFIGASILTLLEILDYIYEVSW 597
            G ++G S+L L+E  + I +  W
Sbjct: 526 FGFWMGGSVLCLIEFGEIIIDFVW 549



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 5/95 (5%)

Query: 162 PGAAPRDLAT-FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYL 220
           PG   ++L   +   +  HG  R    GP   ++ +W L  L   A   +Q     R YL
Sbjct: 18  PGYTYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYL 75

Query: 221 TRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSAL 255
           +    V++  +       FPAVT+CN + F++S +
Sbjct: 76  SWE--VSVSLSVGFKTMDFPAVTICNASPFKYSKI 108


>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
           [Homo sapiens]
          Length = 638

 Score =  127 bits (319), Expect = 3e-29
 Identities = 147/606 (24%), Positives = 241/606 (39%), Gaps = 128/606 (21%)

Query: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203
           P  KE   E    G V   A+ R+L TF  T+ T+HG  R      + L+ T W L  L 
Sbjct: 39  PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 94

Query: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242
           +L A  +Q   L   +  RP L+A+                 +P  P+PV     +    
Sbjct: 95  ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 154

Query: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278
                 +L N+N  +  A   A +      FHL     L      G R            
Sbjct: 155 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 214

Query: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318
                       AA   +     VDIL        +  G Q    + SC++ G  C A  
Sbjct: 215 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 274

Query: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377
           F   +   YG CYT +    +  P    G+  G+ ++L ++Q+ +LP+       S  AG
Sbjct: 275 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 324

Query: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437
           IRV +H +   P++    F V PG +  +S +E  +  L  P+G+C A  E  E EL   
Sbjct: 325 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 384

Query: 438 SAYSVSACRLRCEKEAVLQRCHC--RMVHMPGNETICPP-----------NIYIECADHT 484
           ++Y+  AC + C ++ +++ C C   +  +P     C              +Y +   H 
Sbjct: 385 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 444

Query: 485 LDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRE 538
           L         PC   CP PC  + +       R P+  SA +    L  +   ++++ + 
Sbjct: 445 L---------PCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQR 495

Query: 539 NFLV-LDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS- 596
           + L  +++ ++ L   ++E+   Y +  LL  +G    L+ GAS+L+LLE+L+ + + S 
Sbjct: 496 SSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASA 555

Query: 597 ------WDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNH 650
                   RL+R W     P  +   G S+  ++    Q P P+ G ++        P  
Sbjct: 556 LTLVLGGRRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEP 604

Query: 651 HHPHGP 656
             PH P
Sbjct: 605 SGPHLP 610


>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
           [Homo sapiens]
          Length = 704

 Score =  127 bits (319), Expect = 3e-29
 Identities = 147/606 (24%), Positives = 241/606 (39%), Gaps = 128/606 (21%)

Query: 145 PKEKEAGDEQSLLGAVAPGAAPRDLATFASTS-TLHGLGRACGPGPHGLRRTLWALALLT 203
           P  KE   E    G V   A+ R+L TF  T+ T+HG  R      + L+ T W L  L 
Sbjct: 105 PPPKEGHQE----GLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLG 160

Query: 204 SLAAFLYQAAGLARGYLTRPHLVAM-----------------DPAAPAPVAGFPAV---- 242
           +L A  +Q   L   +  RP L+A+                 +P  P+PV     +    
Sbjct: 161 ALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF 220

Query: 243 ------TLCNINRFRHSALSDADI------FHLANLTGLPPKDRDGHR------------ 278
                 +L N+N  +  A   A +      FHL     L      G R            
Sbjct: 221 ARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTG 280

Query: 279 ------------AAGLRYPEPDMVDIL--------NRTGHQLADMLKSCNFSGHHCSASN 318
                       AA   +     VDIL        +  G Q    + SC++ G  C A  
Sbjct: 281 GDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQ 340

Query: 319 FSVVY-TRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAG 377
           F   +   YG CYT +    +  P    G+  G+ ++L ++Q+ +LP+       S  AG
Sbjct: 341 FRTFHHPTYGSCYTVDGVWTAQRP----GITHGVGLVLRVEQQPHLPL------LSTLAG 390

Query: 378 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 437
           IRV +H +   P++    F V PG +  +S +E  +  L  P+G+C A  E  E EL   
Sbjct: 391 IRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHN 450

Query: 438 SAYSVSACRLRCEKEAVLQRCHC--RMVHMPGNETICPP-----------NIYIECADHT 484
           ++Y+  AC + C ++ +++ C C   +  +P     C              +Y +   H 
Sbjct: 451 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 510

Query: 485 LDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARY----LARKYNRNETYIRE 538
           L         PC   CP PC  + +       R P+  SA +    L  +   ++++ + 
Sbjct: 511 L---------PCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQR 561

Query: 539 NFLV-LDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS- 596
           + L  +++ ++ L   ++E+   Y +  LL  +G    L+ GAS+L+LLE+L+ + + S 
Sbjct: 562 SSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASA 621

Query: 597 ------WDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSLGRAEGGGVSSLLPNH 650
                   RL+R W     P  +   G S+  ++    Q P P+ G ++        P  
Sbjct: 622 LTLVLGGRRLRRAWF--SWPRASPASGASS--IKPEASQMPPPAGGTSDD-------PEP 670

Query: 651 HHPHGP 656
             PH P
Sbjct: 671 SGPHLP 676


>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
           [Homo sapiens]
          Length = 728

 Score =  122 bits (307), Expect = 8e-28
 Identities = 82/314 (26%), Positives = 149/314 (47%), Gaps = 30/314 (9%)

Query: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
           L + + +C F+   C+ +N+S  +   YG CYTFN    S+L  S   G+ +GL +ML  
Sbjct: 334 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 393

Query: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
           +Q +++P+       S   G RV +H Q+EP ++   GF + PG +T +S +++ L  L 
Sbjct: 394 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 447

Query: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETI--CPPN 475
             +G+C         E    S Y+   C   C +E++++ C C  +  P  + +  C   
Sbjct: 448 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 507

Query: 476 --------IYIECADHTLDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARYL 525
                    Y    D + D LG      CF  C  PC++T Y       R P+  S  ++
Sbjct: 508 KHSSWGYCYYKLQVDFSSDHLG------CFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWV 561

Query: 526 ARKYNRNETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGAS 581
            +  +R   Y     R     +++FF+ L  +   +  +  +  LL +LG Q  L+ G+S
Sbjct: 562 FQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSS 621

Query: 582 ILTLLEILDYIYEV 595
           +L+++E+ + ++++
Sbjct: 622 VLSVVEMAELVFDL 635



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 49/201 (24%), Positives = 80/201 (39%), Gaps = 18/201 (8%)

Query: 66  GAAGSGSDSPT-------SGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREA 118
           G  G G+  P          P   P L      LEEQ   P PL   PGL+       + 
Sbjct: 13  GVMGEGTQGPELSLDPDPCSPQSTPGLMK-GNKLEEQD--PRPLQPIPGLMEGNKLEEQD 69

Query: 119 LASPSSR-GQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATF-ASTS 176
            + P S  G M      +     E A P++  A +E      +    + R+L  F  + +
Sbjct: 70  SSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEE----ALIEFHRSYRELFEFFCNNT 125

Query: 177 TLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPV 236
           T+HG  R      + ++   WA+  L +     +Q   L   Y + P  V+++    +  
Sbjct: 126 TIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNINLNSDK 183

Query: 237 AGFPAVTLCNINRFRHSALSD 257
             FPAVT+C +N +R+  + +
Sbjct: 184 LVFPAVTICTLNPYRYPEIKE 204


>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
           [Homo sapiens]
          Length = 692

 Score =  122 bits (307), Expect = 8e-28
 Identities = 82/314 (26%), Positives = 149/314 (47%), Gaps = 30/314 (9%)

Query: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
           L + + +C F+   C+ +N+S  +   YG CYTFN    S+L  S   G+ +GL +ML  
Sbjct: 298 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 357

Query: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
           +Q +++P+       S   G RV +H Q+EP ++   GF + PG +T +S +++ L  L 
Sbjct: 358 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 411

Query: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETI--CPPN 475
             +G+C         E    S Y+   C   C +E++++ C C  +  P  + +  C   
Sbjct: 412 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 471

Query: 476 --------IYIECADHTLDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARYL 525
                    Y    D + D LG      CF  C  PC++T Y       R P+  S  ++
Sbjct: 472 KHSSWGYCYYKLQVDFSSDHLG------CFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWV 525

Query: 526 ARKYNRNETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGAS 581
            +  +R   Y     R     +++FF+ L  +   +  +  +  LL +LG Q  L+ G+S
Sbjct: 526 FQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSS 585

Query: 582 ILTLLEILDYIYEV 595
           +L+++E+ + ++++
Sbjct: 586 VLSVVEMAELVFDL 599



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 42/168 (25%), Positives = 72/168 (42%), Gaps = 10/168 (5%)

Query: 92  LEEQPLPPLPLGRAPGLLAREGQGREALASPSSR-GQMPIEIVCKIKFAEEDAKPKEKEA 150
           LEEQ   P PL   PGL+       +  + P S  G M      +     E A P++  A
Sbjct: 9   LEEQD--PRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTA 66

Query: 151 GDEQSLLGAVAPGAAPRDLATF-ASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFL 209
            +E      +    + R+L  F  + +T+HG  R      + ++   WA+  L +     
Sbjct: 67  EEE----ALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMY 122

Query: 210 YQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSD 257
           +Q   L   Y + P  V+++    +    FPAVT+C +N +R+  + +
Sbjct: 123 WQFGLLFGEYFSYP--VSLNINLNSDKLVFPAVTICTLNPYRYPEIKE 168


>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
           sapiens]
          Length = 669

 Score =  122 bits (307), Expect = 8e-28
 Identities = 82/314 (26%), Positives = 149/314 (47%), Gaps = 30/314 (9%)

Query: 300 LADMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFNADPRSSL-PSRAGGMGSGLEIMLDI 357
           L + + +C F+   C+ +N+S  +   YG CYTFN    S+L  S   G+ +GL +ML  
Sbjct: 275 LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRA 334

Query: 358 QQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP 417
           +Q +++P+       S   G RV +H Q+EP ++   GF + PG +T +S +++ L  L 
Sbjct: 335 EQNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLG 388

Query: 418 QPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETI--CPPN 475
             +G+C         E    S Y+   C   C +E++++ C C  +  P  + +  C   
Sbjct: 389 GDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYR 448

Query: 476 --------IYIECADHTLDSLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNRGSARYL 525
                    Y    D + D LG      CF  C  PC++T Y       R P+  S  ++
Sbjct: 449 KHSSWGYCYYKLQVDFSSDHLG------CFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWV 502

Query: 526 ARKYNRNETYI----RENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGAS 581
            +  +R   Y     R     +++FF+ L  +   +  +  +  LL +LG Q  L+ G+S
Sbjct: 503 FQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSS 562

Query: 582 ILTLLEILDYIYEV 595
           +L+++E+ + ++++
Sbjct: 563 VLSVVEMAELVFDL 576



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)

Query: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
           F + +T+HG  R      + ++   WA+  L +     +Q   L   Y + P  V+++  
Sbjct: 62  FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP--VSLNIN 119

Query: 232 APAPVAGFPAVTLCNINRFRHSALSD 257
             +    FPAVT+C +N +R+  + +
Sbjct: 120 LNSDKLVFPAVTICTLNPYRYPEIKE 145


>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
           sapiens]
          Length = 649

 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 76/335 (22%), Positives = 140/335 (41%), Gaps = 36/335 (10%)

Query: 302 DMLKSCNFSGHHCSASNFSVVY-TRYGKCYTFN-ADPRSSLPSRAGGMGSGLEIMLDIQQ 359
           ++L +C F G  C A NF++ +   +G CYTFN  +  + L +  GG   GL+++L I +
Sbjct: 255 ELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINE 314

Query: 360 EEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQP 419
           EEY P    +       G +V IH Q+E P++  +G  +     T +         L +P
Sbjct: 315 EEYNPFLVSST------GAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEP 368

Query: 420 WGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIE 479
           +  C  +           +AYS+  C   C +  ++++C C     P    + P   Y  
Sbjct: 369 YSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQP----LPPAANYCN 424

Query: 480 CADHT--------LDSLGGGPEGPC--FCPTPCNLTRYGKEISMVRIPNRGSARYLA--- 526
              H         L       E  C   C   C+   +    S+ + P+  S ++L    
Sbjct: 425 YQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVL 484

Query: 527 ---RKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASIL 583
              +    N+   + +   L +F++ L   ++ +  A  +  LL + GGQ+GL++  S++
Sbjct: 485 TWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVV 544

Query: 584 TLLEILDYIY--------EVSWDRLKRVWRRPKTP 610
            ++EI++  +           W + K  W   + P
Sbjct: 545 CVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAP 579



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 4/64 (6%)

Query: 192 LRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFR 251
           LRR LW    LT++A  L+Q A L   + T    V++          FPAVT+CNIN ++
Sbjct: 51  LRRLLWIGFTLTAVALILWQCALLVFSFYT----VSVSIKVHFRKLDFPAVTICNINPYK 106

Query: 252 HSAL 255
           +S +
Sbjct: 107 YSTV 110


>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
          Length = 1219

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 35/132 (26%), Positives = 52/132 (39%), Gaps = 12/132 (9%)

Query: 47   EERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQ-PLPPLPLGRA 105
            EE +K ++R +R  Q Q   A+     +P +   P   + P    +EE  PLPP  L  +
Sbjct: 943  EEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTS 1002

Query: 106  PGLLAREGQGREALASPSSRGQMPIEIVC---------KIKFAEEDAKPKEKEAGDEQSL 156
                 R+G       S    G +P E+ C               E   P   ++  E+SL
Sbjct: 1003 QDGHRRKGDSEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESL 1062

Query: 157  LGAVAPGAAPRD 168
              A +P AA  D
Sbjct: 1063 --AASPMAAKPD 1072


>gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 6 [Homo sapiens]
          Length = 1093

 Score = 40.0 bits (92), Expect = 0.007
 Identities = 26/55 (47%), Positives = 29/55 (52%), Gaps = 9/55 (16%)

Query: 62  HQGCGAAGSGSDSPTSGPHPVPVL------FPLALSLEEQPLPPLP---LGRAPG 107
           H GC +  S S S  S P P+P+L       PLAL     PLPP P   LGRAPG
Sbjct: 817 HSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPAPLPPQPQNGLGRAPG 871


>gi|30425428 deltex homolog 3 [Homo sapiens]
          Length = 347

 Score = 38.9 bits (89), Expect = 0.015
 Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 9/92 (9%)

Query: 43  KETIEERDKRQQRQQRQRQHQGCGAAGSGSDSP---TSGPHPV---PVLFPLALSLEEQP 96
           K  ++E +K  ++ QRQ +  GC A G G + P    +GP P+   P+L P A  L   P
Sbjct: 83  KGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPP 142

Query: 97  LPPLPLGRAPGLLAREGQGREALASPSSRGQM 128
            PPLP    P L  RE    +    P   G++
Sbjct: 143 -PPLPPPLPPRL--REEAEEQESTCPICLGEI 171


>gi|90193619 nuclear matrix transcription factor 4 isoform c [Homo
           sapiens]
          Length = 461

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 23/76 (30%), Positives = 37/76 (48%)

Query: 8   AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
           AA     A A +  ++ A   A A + A A + S ++  +++ ++QQ+QQ     Q  GA
Sbjct: 351 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 410

Query: 68  AGSGSDSPTSGPHPVP 83
           A  G     S P+P P
Sbjct: 411 APQGGGGGDSNPNPPP 426


>gi|90193617 nuclear matrix transcription factor 4 isoform b [Homo
           sapiens]
          Length = 500

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 23/76 (30%), Positives = 37/76 (48%)

Query: 8   AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
           AA     A A +  ++ A   A A + A A + S ++  +++ ++QQ+QQ     Q  GA
Sbjct: 390 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 449

Query: 68  AGSGSDSPTSGPHPVP 83
           A  G     S P+P P
Sbjct: 450 APQGGGGGDSNPNPPP 465


>gi|90193615 nuclear matrix transcription factor 4 isoform b [Homo
           sapiens]
          Length = 500

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 23/76 (30%), Positives = 37/76 (48%)

Query: 8   AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
           AA     A A +  ++ A   A A + A A + S ++  +++ ++QQ+QQ     Q  GA
Sbjct: 390 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 449

Query: 68  AGSGSDSPTSGPHPVP 83
           A  G     S P+P P
Sbjct: 450 APQGGGGGDSNPNPPP 465


>gi|90193613 nuclear matrix transcription factor 4 isoform a [Homo
           sapiens]
          Length = 516

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 23/76 (30%), Positives = 37/76 (48%)

Query: 8   AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
           AA     A A +  ++ A   A A + A A + S ++  +++ ++QQ+QQ     Q  GA
Sbjct: 406 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 465

Query: 68  AGSGSDSPTSGPHPVP 83
           A  G     S P+P P
Sbjct: 466 APQGGGGGDSNPNPPP 481


>gi|90193611 nuclear matrix transcription factor 4 isoform a [Homo
           sapiens]
          Length = 516

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 23/76 (30%), Positives = 37/76 (48%)

Query: 8   AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
           AA     A A +  ++ A   A A + A A + S ++  +++ ++QQ+QQ     Q  GA
Sbjct: 406 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 465

Query: 68  AGSGSDSPTSGPHPVP 83
           A  G     S P+P P
Sbjct: 466 APQGGGGGDSNPNPPP 481


>gi|36054194 nuclear matrix transcription factor 4 isoform a [Homo
           sapiens]
          Length = 516

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 23/76 (30%), Positives = 37/76 (48%)

Query: 8   AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
           AA     A A +  ++ A   A A + A A + S ++  +++ ++QQ+QQ     Q  GA
Sbjct: 406 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 465

Query: 68  AGSGSDSPTSGPHPVP 83
           A  G     S P+P P
Sbjct: 466 APQGGGGGDSNPNPPP 481


>gi|209180475 nuclear matrix transcription factor 4 isoform d [Homo
           sapiens]
          Length = 577

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 23/76 (30%), Positives = 37/76 (48%)

Query: 8   AARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGA 67
           AA     A A +  ++ A   A A + A A + S ++  +++ ++QQ+QQ     Q  GA
Sbjct: 467 AAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGA 526

Query: 68  AGSGSDSPTSGPHPVP 83
           A  G     S P+P P
Sbjct: 527 APQGGGGGDSNPNPPP 542


>gi|40354197 THAP domain containing 11 [Homo sapiens]
          Length = 314

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 32/145 (22%), Positives = 65/145 (44%), Gaps = 8/145 (5%)

Query: 22  RSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHP 81
           R +A   AGA +     +   ++  +++ ++QQ+QQ+Q+Q Q   ++ S S + T+   P
Sbjct: 88  RKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQP 147

Query: 82  VPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALASPSSRGQMPIEIVCKIKFAEE 141
             V    A+ L  Q    +   +APG +      + A  +P+     PI++  +++FA  
Sbjct: 148 NLVSASAAVLLTLQ--ATVDSSQAPGSV------QPAPITPTGEDVKPIDLTVQVEFAAA 199

Query: 142 DAKPKEKEAGDEQSLLGAVAPGAAP 166
           +       A + Q+    +     P
Sbjct: 200 EGAAAAAAASELQAATAGLEAAECP 224


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 30  GADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHPVP-----V 84
           GA S A     +H    +++ ++QQ+QQ+Q+Q Q      SG   P + PHP+       
Sbjct: 467 GAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHH 526

Query: 85  LFPLALSLEEQPLPPLPLGRA 105
             P A+S     L P P G A
Sbjct: 527 AHPYAMSPSLGSLRPYPPGPA 547


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 30  GADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHPVP-----V 84
           GA S A     +H    +++ ++QQ+QQ+Q+Q Q      SG   P + PHP+       
Sbjct: 467 GAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHH 526

Query: 85  LFPLALSLEEQPLPPLPLGRA 105
             P A+S     L P P G A
Sbjct: 527 AHPYAMSPSLGSLRPYPPGPA 547


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,767,614
Number of Sequences: 37866
Number of extensions: 1664895
Number of successful extensions: 7534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 7047
Number of HSP's gapped (non-prelim): 419
length of query: 666
length of database: 18,247,518
effective HSP length: 109
effective length of query: 557
effective length of database: 14,120,124
effective search space: 7864909068
effective search space used: 7864909068
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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