Search of human proteins with 33354281

Search of human proteins with 33354281

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
sapiens]
         (730 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...  1474   0.0  
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...  1260   0.0  
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]        1006   0.0  
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   536   e-152
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   524   e-148
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        516   e-146
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         516   e-146
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   477   e-134
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         448   e-126
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         360   3e-99
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            354   1e-97
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            338   1e-92
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   328   1e-89
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   290   4e-78
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   279   8e-75
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   279   8e-75
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   279   8e-75
gi|171184408 solute carrier family 6 (neurotransmitter transport...   278   1e-74
gi|171184406 solute carrier family 6 (neurotransmitter transport...   278   1e-74
gi|171184404 solute carrier family 6 (neurotransmitter transport...   278   1e-74
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   273   4e-73
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   273   5e-73
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   273   5e-73
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   268   1e-71
gi|188528618 solute carrier family 6 (neurotransmitter transport...   266   7e-71
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   259   8e-69
gi|197276623 solute carrier family 6 (neurotransmitter transport...   256   5e-68
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   256   5e-68
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   200   3e-51
gi|197276625 solute carrier family 6 (neurotransmitter transport...   148   2e-35

>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score = 1474 bits (3816), Expect = 0.0
 Identities = 730/730 (100%), Positives = 730/730 (100%)

Query: 1   MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE 60
           MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
Sbjct: 1   MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE 60

Query: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120
           RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
Sbjct: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120

Query: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180
           VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
Sbjct: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180

Query: 181 QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC 240
           QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
Sbjct: 181 QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC 240

Query: 241 LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR 300
           LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR
Sbjct: 241 LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR 300

Query: 301 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 360
           EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA
Sbjct: 301 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 360

Query: 361 NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA 420
           NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA
Sbjct: 361 NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA 420

Query: 421 LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE 480
           LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE
Sbjct: 421 LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE 480

Query: 481 GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 540
           GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE
Sbjct: 481 GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 540

Query: 541 NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN 600
           NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN
Sbjct: 541 NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN 600

Query: 601 AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG 660
           AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG
Sbjct: 601 AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG 660

Query: 661 RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD 720
           RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD
Sbjct: 661 RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD 720

Query: 721 IMPDMPESDL 730
           IMPDMPESDL
Sbjct: 721 IMPDMPESDL 730


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score = 1260 bits (3261), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 108 MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 167
           MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF
Sbjct: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60

Query: 168 YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 227
           YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK
Sbjct: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120

Query: 228 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 287
           MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT
Sbjct: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180

Query: 288 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 347
           PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL
Sbjct: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240

Query: 348 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 407
           ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY
Sbjct: 241 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 300

Query: 408 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 467
           DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML
Sbjct: 301 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 360

Query: 468 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 527
           VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY
Sbjct: 361 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 420

Query: 528 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 587
           SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA
Sbjct: 421 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 480

Query: 588 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 647
           SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD
Sbjct: 481 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 540

Query: 648 SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA 707
           SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA
Sbjct: 541 SSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA 600

Query: 708 PNGRYGIGYLMADIMPDMPESDL 730
           PNGRYGIGYLMADIMPDMPESDL
Sbjct: 601 PNGRYGIGYLMADIMPDMPESDL 623


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score = 1006 bits (2600), Expect = 0.0
 Identities = 487/735 (66%), Positives = 603/735 (82%), Gaps = 13/735 (1%)

Query: 1   MPKNSKVVKRELDDD-VTESVKDLLSNEDAADDAFKTSELIVDGQEE-KDTDVEEGSEVE 58
           MPKNSKV +RE   + VTESV DLL+ E+  D  +K S L V G+   K   VEE  + E
Sbjct: 1   MPKNSKVTQREHSSEHVTESVADLLALEEPVD--YKQSVLNVAGEAGGKQKAVEEELDAE 58

Query: 59  DERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLE 118
           D RPAWNSKLQYILAQ+GFSVGLGN+WRFPYLCQKNGGGAYL+PYL+LL++IGIPLFFLE
Sbjct: 59  D-RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLE 117

Query: 119 LSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLP 178
           L+VGQRIRRGSIGVW+YI P+LGGIGF+SC+VC FV LYYNVIIGWS+FYF +SFQ PLP
Sbjct: 118 LAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLP 177

Query: 179 WDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVM 238
           W +CP+V+N S   VE ECE+SSATTY+WYREAL+IS SISESGGLNWKMT+CLL AW +
Sbjct: 178 WSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSI 237

Query: 239 VCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKV 298
           V +A++KGIQSSGK++YFSSLFPYVVL CFL+R  LL G++DGI HMFTPKL+ ML+P+V
Sbjct: 238 VGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQV 297

Query: 299 WREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGF 358
           WREAATQVFFALGLGFGGVIAFSSYNK+DNNCHFDA LVSFINFFTSVLATLVVFAVLGF
Sbjct: 298 WREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGF 357

Query: 359 KANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEF 418
           KAN++NEKC+ +N+E I+ +L    +S+D+IP H+N S +T +DY  +Y++I  VKE++F
Sbjct: 358 KANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQF 417

Query: 419 PALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGT 478
            AL L+ C +E+EL+K+VQGTGLAFIAFTEAMTHFPASPFWSVMFFLML+NLGLGSM GT
Sbjct: 418 SALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477

Query: 479 IEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVI 538
           + GI TPI+DTFKV KE+ TV CC+ AF +GL+FVQRSGNYFVTMFDDYSATLPL ++VI
Sbjct: 478 MAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVI 537

Query: 539 LENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPG 598
           LENIAV ++YG  KFM++L +MLGF P R+Y+YMWK++SPL +  L  AS++ +G++PPG
Sbjct: 538 LENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPG 597

Query: 599 YNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYK 658
           Y+AWI+++A+E +L +P W + + ++L+V A LP+PVVF++R F+L+ D S N  SV+YK
Sbjct: 598 YSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGS-NTLSVSYK 656

Query: 659 RGRVLKEPVNL-EGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA--PNGRYGIG 715
           +GR++K+  NL E D+T  I  K+PSE PSP      Y     +  L+T+  PNGRYG G
Sbjct: 657 KGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSG 716

Query: 716 YLMADIMPDMPESDL 730
           YL+A      PES+L
Sbjct: 717 YLLA----STPESEL 727


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  536 bits (1380), Expect = e-152
 Identities = 268/601 (44%), Positives = 390/601 (64%), Gaps = 35/601 (5%)

Query: 57  VEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFF 116
           +E  RP W + LQ++ A + ++VGLGNVWRFPYLCQ  GGG++L+PY+I+L+V G+PL +
Sbjct: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60

Query: 117 LELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQP 176
           LEL+VGQR+R+GSIG W  ISP L G+G AS VV +F+++YYNVI  W+ +Y   SFQ P
Sbjct: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120

Query: 177 LPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAW 236
           LPW  CPL  N +HT  + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+  +CLL AW
Sbjct: 121 LPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178

Query: 237 VMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEP 296
           ++V L +++G +S+GK++YF++  PY VLI +LIR   L+G+ +G+ +MFTPK+E +  P
Sbjct: 179 LVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANP 238

Query: 297 KVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVL 356
           K W  AATQ+FF+LGLGFG +IAF+SYN+  NNC   A++VS IN FTS+ A++V F++ 
Sbjct: 239 KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIY 298

Query: 357 GFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTAEDYHLVYDI 409
           GFKA    E C+ + S  +         FL   N+ Q        +    A  Y   Y  
Sbjct: 299 GFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLASAYPSKY-- 348

Query: 410 IQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVN 469
                 E FP   + +C +E EL+ AVQGTGLAFI +TEA+ +   S  WSV++F ML+ 
Sbjct: 349 -----SEMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLM 401

Query: 470 LGLGSMFGTIEGIVTPIVD----TFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFD 525
           LG+GSM G    I+TP+ D    +  + KE ++ + CL+   IG++F   +GNY+  +F+
Sbjct: 402 LGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFN 461

Query: 526 DYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLL 585
           DY+ATL LL++V++E IAVC+VYG+ +F  DLK M G A S Y+  MW  +SPL+++SL 
Sbjct: 462 DYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLF 521

Query: 586 IASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV----VFIVR 640
           +  + +  L+    Y AW   +       YP + L V   LV  + + +P+     F+ R
Sbjct: 522 VFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR 581

Query: 641 R 641
           R
Sbjct: 582 R 582


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  524 bits (1350), Expect = e-148
 Identities = 258/279 (92%), Positives = 266/279 (95%), Gaps = 3/279 (1%)

Query: 1   MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE 60
           MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
Sbjct: 1   MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE 60

Query: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120
           RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
Sbjct: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120

Query: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180
           VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
Sbjct: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180

Query: 181 QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC 240
           QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
Sbjct: 181 QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC 240

Query: 241 LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSI 279
           LAMIKGIQSSGK+   S L P+++L+  +     L+ S+
Sbjct: 241 LAMIKGIQSSGKV---SMLEPFLILLITISGFIPLSNSV 276


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  516 bits (1330), Expect = e-146
 Identities = 252/592 (42%), Positives = 380/592 (64%), Gaps = 22/592 (3%)

Query: 56  EVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLF 115
           ++ DERP W++K QY+L+  GF+VGLGN+WRFPYLCQ  GGGA+L+PY+I L+  GIP+F
Sbjct: 13  DLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72

Query: 116 FLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQ 175
            +EL++GQR+R+GS+GVW  ISP L G+G     + + ++LYYN I+ W L+Y   SFQ 
Sbjct: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132

Query: 176 PLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAA 235
           PLPW  CP   N +  FVE EC+ SSA +Y+WYR+ LNI++ I++SG + W + ICL A+
Sbjct: 133 PLPWSSCPPDLNRTG-FVE-ECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAAS 190

Query: 236 WVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLE 295
           W +V + +I+GI+++GK+IYF++LFPY+VL  FLIR   L G+  G+ ++FTP + I+  
Sbjct: 191 WAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQN 250

Query: 296 PKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAV 355
           P+VW +AATQ+FF+L L FGG IAF+SYN   N+C  DAV+++ +N  TS+ A++ VF+V
Sbjct: 251 PRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSV 310

Query: 356 LGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKE 415
           LGFKA    E C+ +N  +++                    +++ +DY  V   +     
Sbjct: 311 LGFKATNDYEHCLDRNILSLINDFDFPE------------QSISRDDYPAVLMHLNATWP 358

Query: 416 EEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSM 475
           +    L L +C +E+ L+K+  G GLAF+ FTE   H P +P W+++FF ML  LGL +M
Sbjct: 359 KRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTM 418

Query: 476 FGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATL 531
           FGT+E ++TP++D       V KE LT + CL+ F     F  +SGNY++ +FD+++A+ 
Sbjct: 419 FGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASP 478

Query: 532 PLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVN 591
            LL++  LE + V +VYG+ +F +D+  M G  PS Y+   W+ +SPL LL++ +A ++ 
Sbjct: 479 NLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPL-LLTIFVAYIIL 537

Query: 592 MGLSPPGYNAW---IEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
           +   P  Y AW    E   S +   YP W    CV L +  +L VPV  + +
Sbjct: 538 LFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQ 589


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  516 bits (1329), Expect = e-146
 Identities = 262/593 (44%), Positives = 370/593 (62%), Gaps = 35/593 (5%)

Query: 56  EVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLF 115
           E    RP W++K QY+L  +GF VGLGNVWRFPYLCQ +GGGA+++P+LILL++ GIPL 
Sbjct: 27  EEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLL 86

Query: 116 FLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQ 175
           +LE ++GQR+RRGS+GVW+ I P L G+G AS +  + V LYYN II W ++Y   SFQ+
Sbjct: 87  YLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQE 146

Query: 176 PLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAA 235
           PLPW  CPL  N + T    EC +SS   Y+WYRE LNIS+SIS+SG + W M +CL  A
Sbjct: 147 PLPWSDCPL--NENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACA 204

Query: 236 WVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLE 295
           W ++ +  I+GI+++GK +Y +S  PYVVL  FLIR   L G+ +GI  +FTP +  + +
Sbjct: 205 WSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQ 264

Query: 296 PKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAV 355
           P  W +A  QVFF+  L FGG+I+FSSYN   NNC  D+V+VS IN FTSV   +VV++V
Sbjct: 265 PDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSV 324

Query: 356 LGFKANVINEKCITQNSETIMK--FLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKV 413
           +GF+A    + C + N  T++    L  GN++Q+                    D+ Q+ 
Sbjct: 325 IGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF-----------------VDMQQRC 367

Query: 414 KEEE---FPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNL 470
              +   +  L   +C I   L++AV+GTGLAFI FTEA+T  P SP WSV+FF+ML  L
Sbjct: 368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCL 427

Query: 471 GLGSMFGTIEGIVTPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDD 526
           GL SMFG +EG+V P+ D      K  KE+LT + CL  F IG IF   SG Y++++ D 
Sbjct: 428 GLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDS 487

Query: 527 YSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLI 586
           Y+ ++PLLI+   E  +V +VYG+D+F +D++ M+G  P+ ++   W+ +SPL++L + +
Sbjct: 488 YAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFL 547

Query: 587 ASVVNMGLSPPGYNAWIEDKASEEF-----LSYPTWGLVVCVSLVVFAILPVP 634
              V        Y+ W  D   EEF     +SYP W  VV V +     L +P
Sbjct: 548 FFFVVEVSQELTYSIW--DPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIP 598


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  477 bits (1227), Expect = e-134
 Identities = 251/601 (41%), Positives = 362/601 (60%), Gaps = 72/601 (11%)

Query: 57  VEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFF 116
           +E  RP W + LQ++ A + ++VGLGNVWRFPYLCQ  GGG++L+PY+I+L+V G+PL +
Sbjct: 1   MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60

Query: 117 LELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQP 176
           LEL+VGQR+R+GSIG W  ISP L G+G AS VV +F+++YYNVI  W+ +Y   SFQ P
Sbjct: 61  LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120

Query: 177 LPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAW 236
           LPW  CPL  N +HT  + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+  +CLL AW
Sbjct: 121 LPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178

Query: 237 VMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEP 296
           ++V L +++G +S+GKI                                     E +  P
Sbjct: 179 LVVYLCILRGTESTGKI-------------------------------------EQLANP 201

Query: 297 KVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVL 356
           K W  AATQ+FF+LGLGFG +IAF+SYN+  NNC   A++VS IN FTS+ A++V F++ 
Sbjct: 202 KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIY 261

Query: 357 GFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTAEDYHLVYDI 409
           GFKA    E C+ + S  +         FL   N+ Q        +    A  Y   Y  
Sbjct: 262 GFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLASAYPSKYS- 312

Query: 410 IQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVN 469
                 E FP   + +C +E EL+ AVQGTGLAFI +TEA+ +   S  WSV++F ML+ 
Sbjct: 313 ------EMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLM 364

Query: 470 LGLGSMFGTIEGIVTPIVDTFKVR----KEILTVICCLLAFCIGLIFVQRSGNYFVTMFD 525
           LG+GSM G    I+TP+ D+  +     KE ++ + CL+   IG++F   +GNY+  +F+
Sbjct: 365 LGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFN 424

Query: 526 DYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLL 585
           DY+ATL LL++V++E IAVC+VYG+ +F  DLK M G A S Y+  MW  +SPL+++SL 
Sbjct: 425 DYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLF 484

Query: 586 IASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV----VFIVR 640
           +  + +  L+    Y AW   +       YP + L V   LV  + + +P+     F+ R
Sbjct: 485 VFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR 544

Query: 641 R 641
           R
Sbjct: 545 R 545


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  448 bits (1153), Expect = e-126
 Identities = 223/594 (37%), Positives = 350/594 (58%), Gaps = 7/594 (1%)

Query: 55  SEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPL 114
           SEV   RP W+SK +YILAQVGFS+    +WRF YL   +GG ++   Y+ +L ++G+PL
Sbjct: 97  SEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPL 156

Query: 115 FFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQ 174
            FLE++ GQ +R+G +GVW  I+P +GG+G++S +VC+ + LY+NV+  W +FY SQSFQ
Sbjct: 157 LFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQ 216

Query: 175 QPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLA 234
            P+PW++CPL  N+S    +PECE+++ + Y+WY++AL  S  I + G   + + +    
Sbjct: 217 FPVPWEKCPLTMNSSG--FDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFL 274

Query: 235 AWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIML 294
            W +V   MI G++S+GK+IY   L P  +++ F IR  LL G+  G++ +   K+  + 
Sbjct: 275 CWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVY 334

Query: 295 EPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFA 354
              VW  A  QV    G+G G V + +SY  + NNC  DA LVS IN  T ++ T   F 
Sbjct: 335 NMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFC 394

Query: 355 VLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVK 414
           VLGF A VI  +C  +N+E ++K + +G +  D  P    L   T+     +  + Q +K
Sbjct: 395 VLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIK 454

Query: 415 EEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGS 474
                   +  C IE +  KA +G   AF++F EAM+  P S FWS +FFLML+ +GL S
Sbjct: 455 --SMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSS 512

Query: 475 MFGTIEGIVTPIVDT---FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATL 531
             G ++GI+TP+ DT   F+   ++L V   LL F  GL F + SG+YF+ +  DY    
Sbjct: 513 AIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVF 572

Query: 532 PLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVN 591
           P+++VV+ E +AV + YG  +F+ DL  +LG   S  + ++W ++ P++LL + +  +V+
Sbjct: 573 PIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVH 632

Query: 592 MGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLI 645
           + + P  Y +W    + E    YP W L++ ++L    ILP+P  F+  R + I
Sbjct: 633 LCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRI 686


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  360 bits (924), Expect = 3e-99
 Identities = 211/623 (33%), Positives = 320/623 (51%), Gaps = 99/623 (15%)

Query: 36  TSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNG 95
           T +L++   ++ D D++   +    R  W  KL ++L+ +G+ VGLGNVWRFPY    NG
Sbjct: 14  TPDLLMTPSDQGDVDLDV--DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNG 71

Query: 96  GGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVA 155
           GGA+L+PY ++L + GIPLFFLELS+GQ    G + VW  ISP   G G A  ++   VA
Sbjct: 72  GGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVA 130

Query: 156 LYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SAT 203
           +YYN+II + LFY   S    LPW+ C    N          +              S +
Sbjct: 131 IYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPS 190

Query: 204 TYYWYREALNISSS--ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFP 261
             YW R  L+I  S  I   G + W + +CLL AWV+V L ++KG++SSGK++YF++ FP
Sbjct: 191 EEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFP 250

Query: 262 YVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFS 321
           Y++L+  L+R   L G+  GI+   TP+   +L  KVW EAA Q+F++LG+GFGG++ F+
Sbjct: 251 YLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFA 310

Query: 322 SYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKM 381
           SYN    N + D         F   L   +   + GF                   F  +
Sbjct: 311 SYNTFHQNIYRDT--------FIVTLGNAITSILAGFAI-----------------FSVL 345

Query: 382 GNISQDI-IPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTG 440
           G +SQ++ +P                                       +++ KA  G G
Sbjct: 346 GYMSQELGVP--------------------------------------VDQVAKA--GPG 365

Query: 441 LAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF----KVRKEI 496
           LAF+ + +AMT  P SPFWS +FF ML+ LGL S F  +E IVT + D F    + +K +
Sbjct: 366 LAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAV 425

Query: 497 LTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMED 556
            + + C+  + +GLI     G Y++ + DDYSA+  L++VVI   +AV  VYGI +F  D
Sbjct: 426 FSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRD 485

Query: 557 LKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPT 616
           +  MLGF P  Y+   W ++SP  LL+L++ S+V     P  Y ++           +P 
Sbjct: 486 IHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVK--YQPSEYGSY----------RFPP 533

Query: 617 WGLVVCVSLVVFAILPVPVVFIV 639
           W  ++ + + + + L +P   +V
Sbjct: 534 WAELLGILMGLLSCLMIPAGMLV 556


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  354 bits (909), Expect = 1e-97
 Identities = 198/604 (32%), Positives = 310/604 (51%), Gaps = 107/604 (17%)

Query: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120
           R  W  K+ ++L+ VGF+V L NVWRFPYLC KNGGGA+L+PY + L++ G+PLF++EL+
Sbjct: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115

Query: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180
           +GQ  R G+  VW  I P   G+G+A  ++  +V  YYNVII WSL+Y   SF   LPW 
Sbjct: 116 LGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174

Query: 181 QCPLVKNASHTFVEPECEQ---------SSATTYYWYREA------------LNISSSIS 219
            C       HT+  P C            + T Y  Y+              L+ SS I 
Sbjct: 175 DC------GHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIH 228

Query: 220 ESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSI 279
           + G   W++ +CL+   +++  ++ KG+++SGK+++ ++  PY VL   L+    L G+ 
Sbjct: 229 DIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGAS 288

Query: 280 DGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSF 339
           +GI          + E  VW +AATQ+FF+LG GFG +IAF+SYNK DNNC+ DA+L S 
Sbjct: 289 NGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSS 348

Query: 340 INFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVT 399
           IN  TS ++   +F++LG+ A+                             H +N+  V 
Sbjct: 349 INCITSFVSGFAIFSILGYMAH----------------------------EHKVNIEDVA 380

Query: 400 AEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFW 459
            E                                    G GL FI + EA++    S FW
Sbjct: 381 TE------------------------------------GAGLVFILYPEAISTLSGSTFW 404

Query: 460 SVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRK---EILTVICCLLAFCIGLIFVQRS 516
           +V+FF+ML+ LGL S  G +E ++T + D F+V K   ++ T       F + L  + + 
Sbjct: 405 AVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKG 464

Query: 517 GNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 576
           G Y +T+ D ++A   +L  V++E I V + YG+D+F  D++ M+GF P  Y+   WK++
Sbjct: 465 GIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFV 524

Query: 577 SPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVV 636
           SP  LL +++ S++N    P  Y+ +I          +P W   V   + + +++ VP+ 
Sbjct: 525 SPAFLLFVVVVSIIN--FKPLTYDDYI----------FPPWANWVGWGIALSSMVLVPIY 572

Query: 637 FIVR 640
            I +
Sbjct: 573 VIYK 576


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  338 bits (867), Expect = 1e-92
 Identities = 187/595 (31%), Positives = 313/595 (52%), Gaps = 90/595 (15%)

Query: 58  EDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFL 117
           + ER  W  K+ ++L+ +G++V LGNVWRFPY+C +NGGGA+LLPY I+ +  GIPLF++
Sbjct: 76  QGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYM 135

Query: 118 ELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPL 177
           EL++GQ  R G I +W  I P   GIG+A C++ +++A YYN I+ W+L+Y   SF   L
Sbjct: 136 ELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQL 195

Query: 178 PWDQCPL---VKNASHTFVEPEC----EQSSATTYYWYREALNI--SSSISESGGLNWKM 228
           PW  C       N ++ F E         +S    ++ R  L I  S  + + GG++W++
Sbjct: 196 PWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255

Query: 229 TICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTP 288
            +C++  + ++  ++ KG+++SGK+++ ++ FPY++L   L+R   L G+  G+     P
Sbjct: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKP 315

Query: 289 KLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLA 348
             + +LE  VW +AA Q+FF+LG GFG ++AF+SYNK +NNC            +   L 
Sbjct: 316 NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNC------------YQDALV 363

Query: 349 TLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYD 408
           T VV              C+T      + F  +G +++                      
Sbjct: 364 TSVV-------------NCMTSFVSGFVIFTVLGYMAE---------------------- 388

Query: 409 IIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLV 468
               ++ E+          + E    A  G  L FI + EA+ + PAS F++++FFLML+
Sbjct: 389 ----MRNED----------VSEVAKDA--GPSLLFITYAEAIANMPASTFFAIIFFLMLI 432

Query: 469 NLGLGSMFGTIEGIVTPIVDTFK----VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMF 524
            LGL S F  +EG++T ++D F      R+E   +   +  F   L+ +   G Y V + 
Sbjct: 433 TLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492

Query: 525 DDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSL 584
           ++Y+    +L V ++E +AV + YGI +F  D+K+MLGF+P  ++   W  ISPL LL +
Sbjct: 493 EEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFI 552

Query: 585 LIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVV--CVSLVVFAILPVPVVF 637
           + + +    +SPP    +          +YP W +++  C+    F  +P  + +
Sbjct: 553 ICSFL----MSPPQLRLF--------QYNYPYWSIILGYCIGTSSFICIPTYIAY 595


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  328 bits (840), Expect = 1e-89
 Identities = 191/599 (31%), Positives = 304/599 (50%), Gaps = 106/599 (17%)

Query: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119
           +R  W  K+ ++L+ +GF+V L NVWRFPYLC KNGGGA+L+PYL+ +++ G+PLF++EL
Sbjct: 59  DRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMEL 118

Query: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179
           ++GQ  R G+ GVW  I P L G+GF   ++  +V  +YNVII W+L Y   SF   LPW
Sbjct: 119 ALGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPW 177

Query: 180 DQCPLVKNASHTFVEPECEQS------------------SATTYYWYREALNISSS--IS 219
             C      ++++  P C  +                  +    Y+ R  L++  S  I 
Sbjct: 178 IHC------NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGID 231

Query: 220 ESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSI 279
           + G   W++T CL+   V++  ++ KG+++SGK+++ ++  PYVVL   L+R   L G+I
Sbjct: 232 DLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAI 291

Query: 280 DGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSF 339
           DGIR   +     + E  VW +AATQV F+LG+GFG +IAFSSYNK  N           
Sbjct: 292 DGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTN----------- 340

Query: 340 INFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVT 399
            N +   + T  + ++  F +  +           +  FL  G ++Q    H + +  V 
Sbjct: 341 -NCYRDAIVTTSINSLTSFSSGFV-----------VFSFL--GYMAQK---HSVPIGDV- 382

Query: 400 AEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFW 459
                                              A  G GL FI + EA+   P S  W
Sbjct: 383 -----------------------------------AKDGPGLIFIIYPEAIATLPLSSAW 407

Query: 460 SVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKV---RKEILTVICCLLAFCIGLIFVQRS 516
           +V+FF+ML+ LG+ S  G +E ++T ++D F++    +E+ T+   L  F + L  V   
Sbjct: 408 AVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNG 467

Query: 517 GNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 576
           G Y  T+ D ++A   +L  V++E I V + YG+ +F +D++ M G  PS Y+   WK +
Sbjct: 468 GIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLV 527

Query: 577 SPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV 635
           SP  LL +++ S+V     PP Y A+I          +P W   +   +   ++  VP+
Sbjct: 528 SPCFLLFVVVVSIVT--FRPPHYGAYI----------FPDWANALGWVIATSSMAMVPI 574


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  290 bits (741), Expect = 4e-78
 Identities = 135/323 (41%), Positives = 202/323 (62%), Gaps = 30/323 (9%)

Query: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120
           R  W  ++ +I++ VGF+VGLGNVWRFPYLC KNGGG +L+PY+++ +V GIP+FFLE+S
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180
           +GQ ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW 
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 181 QCPLVKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSS 217
            C       HT+  P+C                       ++ S    +W  + L +S  
Sbjct: 171 TC------GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGG 224

Query: 218 ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNG 277
           +   G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVVL+  L+R  LL G
Sbjct: 225 LEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPG 284

Query: 278 SIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLV 337
           ++DGI +   P    +  P+VW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA+++
Sbjct: 285 ALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIIL 344

Query: 338 SFINFFTSVLATLVVFAVLGFKA 360
           + IN  TS  A  VVF++LGF A
Sbjct: 345 ALINSGTSFFAGFVVFSILGFMA 367



 Score =  125 bits (315), Expect = 1e-28
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 378 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 437

Query: 490 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 438 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 497

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 498 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 546

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPV 635
                 YP WG  +  +  + ++L VP+
Sbjct: 547 YNNTYVYPWWGEAMGWAFALSSMLCVPL 574


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  279 bits (713), Expect = 8e-75
 Identities = 135/327 (41%), Positives = 200/327 (61%), Gaps = 27/327 (8%)

Query: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119
           +R  W ++++++L  VG++VGLGNVWRFPYLC +NGGGA++ PY I+L+  GIPLFF+EL
Sbjct: 26  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 85

Query: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179
           S GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF  S    LPW
Sbjct: 86  SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 144

Query: 180 DQC-------------------------PLVKNASHTFVEPECEQSSATTYYWYREALNI 214
             C                          L  N SH  +    +++S +  YW    L +
Sbjct: 145 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEEYWRLYVLKL 203

Query: 215 SSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFL 274
           S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL    +R   
Sbjct: 204 SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVT 263

Query: 275 LNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA 334
           L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK  NNC+ D+
Sbjct: 264 LEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDS 323

Query: 335 VLVSFINFFTSVLATLVVFAVLGFKAN 361
           V++S  N  TSV A  V+F++LGF AN
Sbjct: 324 VIISITNCATSVYAGFVIFSILGFMAN 350



 Score =  127 bits (319), Expect = 4e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 360 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 419

Query: 490 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 549
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 420 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 479

Query: 550 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 609
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 480 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 530

Query: 610 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
               YP W + +   + + ++L +P+  + R
Sbjct: 531 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 558


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  279 bits (713), Expect = 8e-75
 Identities = 135/327 (41%), Positives = 200/327 (61%), Gaps = 27/327 (8%)

Query: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119
           +R  W ++++++L  VG++VGLGNVWRFPYLC +NGGGA++ PY I+L+  GIPLFF+EL
Sbjct: 99  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 158

Query: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179
           S GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF  S    LPW
Sbjct: 159 SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 217

Query: 180 DQC-------------------------PLVKNASHTFVEPECEQSSATTYYWYREALNI 214
             C                          L  N SH  +    +++S +  YW    L +
Sbjct: 218 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEEYWRLYVLKL 276

Query: 215 SSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFL 274
           S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL    +R   
Sbjct: 277 SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVT 336

Query: 275 LNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA 334
           L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK  NNC+ D+
Sbjct: 337 LEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDS 396

Query: 335 VLVSFINFFTSVLATLVVFAVLGFKAN 361
           V++S  N  TSV A  V+F++LGF AN
Sbjct: 397 VIISITNCATSVYAGFVIFSILGFMAN 423



 Score =  127 bits (319), Expect = 4e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 433 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 492

Query: 490 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 549
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 493 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 552

Query: 550 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 609
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 553 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 603

Query: 610 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
               YP W + +   + + ++L +P+  + R
Sbjct: 604 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 631


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  279 bits (713), Expect = 8e-75
 Identities = 135/327 (41%), Positives = 200/327 (61%), Gaps = 27/327 (8%)

Query: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119
           +R  W ++++++L  VG++VGLGNVWRFPYLC +NGGGA++ PY I+L+  GIPLFF+EL
Sbjct: 45  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 104

Query: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179
           S GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF  S    LPW
Sbjct: 105 SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 163

Query: 180 DQC-------------------------PLVKNASHTFVEPECEQSSATTYYWYREALNI 214
             C                          L  N SH  +    +++S +  YW    L +
Sbjct: 164 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEEYWRLYVLKL 222

Query: 215 SSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFL 274
           S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL    +R   
Sbjct: 223 SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVT 282

Query: 275 LNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA 334
           L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK  NNC+ D+
Sbjct: 283 LEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDS 342

Query: 335 VLVSFINFFTSVLATLVVFAVLGFKAN 361
           V++S  N  TSV A  V+F++LGF AN
Sbjct: 343 VIISITNCATSVYAGFVIFSILGFMAN 369



 Score =  127 bits (319), Expect = 4e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 379 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 438

Query: 490 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 549
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 439 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 498

Query: 550 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 609
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 499 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 549

Query: 610 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
               YP W + +   + + ++L +P+  + R
Sbjct: 550 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 577


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  278 bits (712), Expect = 1e-74
 Identities = 134/325 (41%), Positives = 197/325 (60%), Gaps = 11/325 (3%)

Query: 44  QEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPY 103
           +E +  D E+  +V+D R  W +K++++L+  G  +GLGNVWRFPYLC KNGGGA+ +PY
Sbjct: 20  EEGEKLDQEDEDQVKD-RGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPY 78

Query: 104 LILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIG 163
            I   V GIP+FFLE+++GQ   +GS+  W  I P   GIG AS V+  ++ +YY +I+ 
Sbjct: 79  FIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILA 138

Query: 164 WSLFYFSQSFQQPLPWDQCPLVKNASHT----------FVEPECEQSSATTYYWYREALN 213
           W+LFY   SF   LPW  C    N  H            V P    +S    +W R  L 
Sbjct: 139 WALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLG 198

Query: 214 ISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAF 273
           I+S I + G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR  
Sbjct: 199 ITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGV 258

Query: 274 LLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFD 333
            L G+  GI +   P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D
Sbjct: 259 TLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKD 318

Query: 334 AVLVSFINFFTSVLATLVVFAVLGF 358
            + + F+N  TS +A  VVF++LGF
Sbjct: 319 CIALCFLNSATSFVAGFVVFSILGF 343



 Score =  117 bits (292), Expect = 5e-26
 Identities = 68/212 (32%), Positives = 113/212 (53%), Gaps = 18/212 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 490
           A  G GLAFIAF +A+T  P S  WS +FF+ML+ LGL S F  +E +VT  +D F    
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 491 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY-SATLPLLIVVILENIAVCFV 547
               R+E+L +   ++ + IGL  V   G Y   +FD Y S+ + LL + + E + + +V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D+F ++++DM+G+ P       W +++P + L+  + S+     +P  YN       
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK--YTPLKYN------- 526

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIV 639
                 YP WG  +   L + +++ VP+  ++
Sbjct: 527 --NVYVYPPWGYSIGWFLALSSMVCVPLFVVI 556


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  278 bits (712), Expect = 1e-74
 Identities = 134/325 (41%), Positives = 197/325 (60%), Gaps = 11/325 (3%)

Query: 44  QEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPY 103
           +E +  D E+  +V+D R  W +K++++L+  G  +GLGNVWRFPYLC KNGGGA+ +PY
Sbjct: 20  EEGEKLDQEDEDQVKD-RGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPY 78

Query: 104 LILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIG 163
            I   V GIP+FFLE+++GQ   +GS+  W  I P   GIG AS V+  ++ +YY +I+ 
Sbjct: 79  FIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILA 138

Query: 164 WSLFYFSQSFQQPLPWDQCPLVKNASHT----------FVEPECEQSSATTYYWYREALN 213
           W+LFY   SF   LPW  C    N  H            V P    +S    +W R  L 
Sbjct: 139 WALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLG 198

Query: 214 ISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAF 273
           I+S I + G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR  
Sbjct: 199 ITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGV 258

Query: 274 LLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFD 333
            L G+  GI +   P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D
Sbjct: 259 TLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKD 318

Query: 334 AVLVSFINFFTSVLATLVVFAVLGF 358
            + + F+N  TS +A  VVF++LGF
Sbjct: 319 CIALCFLNSATSFVAGFVVFSILGF 343



 Score =  117 bits (292), Expect = 5e-26
 Identities = 68/212 (32%), Positives = 113/212 (53%), Gaps = 18/212 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 490
           A  G GLAFIAF +A+T  P S  WS +FF+ML+ LGL S F  +E +VT  +D F    
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 491 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY-SATLPLLIVVILENIAVCFV 547
               R+E+L +   ++ + IGL  V   G Y   +FD Y S+ + LL + + E + + +V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D+F ++++DM+G+ P       W +++P + L+  + S+     +P  YN       
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK--YTPLKYN------- 526

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIV 639
                 YP WG  +   L + +++ VP+  ++
Sbjct: 527 --NVYVYPPWGYSIGWFLALSSMVCVPLFVVI 556


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  278 bits (712), Expect = 1e-74
 Identities = 134/325 (41%), Positives = 197/325 (60%), Gaps = 11/325 (3%)

Query: 44  QEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPY 103
           +E +  D E+  +V+D R  W +K++++L+  G  +GLGNVWRFPYLC KNGGGA+ +PY
Sbjct: 20  EEGEKLDQEDEDQVKD-RGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPY 78

Query: 104 LILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIG 163
            I   V GIP+FFLE+++GQ   +GS+  W  I P   GIG AS V+  ++ +YY +I+ 
Sbjct: 79  FIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILA 138

Query: 164 WSLFYFSQSFQQPLPWDQCPLVKNASHT----------FVEPECEQSSATTYYWYREALN 213
           W+LFY   SF   LPW  C    N  H            V P    +S    +W R  L 
Sbjct: 139 WALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLG 198

Query: 214 ISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAF 273
           I+S I + G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR  
Sbjct: 199 ITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGV 258

Query: 274 LLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFD 333
            L G+  GI +   P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D
Sbjct: 259 TLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKD 318

Query: 334 AVLVSFINFFTSVLATLVVFAVLGF 358
            + + F+N  TS +A  VVF++LGF
Sbjct: 319 CIALCFLNSATSFVAGFVVFSILGF 343



 Score =  117 bits (292), Expect = 5e-26
 Identities = 68/212 (32%), Positives = 113/212 (53%), Gaps = 18/212 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 490
           A  G GLAFIAF +A+T  P S  WS +FF+ML+ LGL S F  +E +VT  +D F    
Sbjct: 356 AESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQL 415

Query: 491 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY-SATLPLLIVVILENIAVCFV 547
               R+E+L +   ++ + IGL  V   G Y   +FD Y S+ + LL + + E + + +V
Sbjct: 416 RKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWV 475

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D+F ++++DM+G+ P       W +++P + L+  + S+     +P  YN       
Sbjct: 476 YGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK--YTPLKYN------- 526

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIV 639
                 YP WG  +   L + +++ VP+  ++
Sbjct: 527 --NVYVYPPWGYSIGWFLALSSMVCVPLFVVI 556


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  273 bits (698), Expect = 4e-73
 Identities = 145/368 (39%), Positives = 209/368 (56%), Gaps = 41/368 (11%)

Query: 34  FKTSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQK 93
           FK  E        ++  V E  E +D R  W+ K  Y+L+ +G++VGLGNVWRFPYL   
Sbjct: 10  FKCREKEKVSASSENFHVGENDENQD-RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYS 68

Query: 94  NGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYF 153
           NGGGA+L+PY I+L + G+PLFFLE S+GQ    G + VW  I P   G+G    ++  F
Sbjct: 69  NGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWR-ILPLFQGVGITMVLISIF 127

Query: 154 VALYYNVIIGWSLFYFSQSFQQPLPWDQCPLV--KNASHTFVEPECEQSSA--------- 202
           V +YYNVII +SL+Y   SFQ  LPW  C     KN S + +   C  S+          
Sbjct: 128 VTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQ 187

Query: 203 --------------------------TTYYWYREALNISSSISESGGLNWKMTICLLAAW 236
                                     +  YW + AL  SS ++E+G + W + +CLL AW
Sbjct: 188 MNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAW 247

Query: 237 VMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEI--ML 294
           ++V  A+ KGI+SSGK++YF++LFPYVVL+  L+R   L G+  GI +    +     + 
Sbjct: 248 LIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLK 307

Query: 295 EPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFA 354
           E +VW++AATQ+F++L + +GG++A SSYNK  NNC  DA++V   N  TSV A   +F+
Sbjct: 308 EAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFS 367

Query: 355 VLGFKANV 362
           +LG  A++
Sbjct: 368 ILGHMAHI 375


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  273 bits (697), Expect = 5e-73
 Identities = 131/323 (40%), Positives = 194/323 (60%), Gaps = 40/323 (12%)

Query: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120
           R  W  ++ +I++ VGF+VGLGNVWRFPYLC KNGGG +L+PY+++ +V GIP+FFLE+S
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180
           +GQ ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW 
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 181 QCPLVKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSS 217
            C       HT+  P+C                       ++ S    +W  + L +S  
Sbjct: 171 TC------GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGG 224

Query: 218 ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNG 277
           +   G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVVL+  L+R  LL G
Sbjct: 225 LEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPG 284

Query: 278 SIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLV 337
           ++DGI +   P    +  P+VW +A TQ+FF+  +G G + A  SYN+ +NNC+      
Sbjct: 285 ALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG---- 340

Query: 338 SFINFFTSVLATLVVFAVLGFKA 360
                 TS  A  VVF++LGF A
Sbjct: 341 ------TSFFAGFVVFSILGFMA 357



 Score =  125 bits (315), Expect = 1e-28
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427

Query: 490 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 536

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPV 635
                 YP WG  +  +  + ++L VP+
Sbjct: 537 YNNTYVYPWWGEAMGWAFALSSMLCVPL 564


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  273 bits (697), Expect = 5e-73
 Identities = 142/358 (39%), Positives = 205/358 (57%), Gaps = 52/358 (14%)

Query: 49  TDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLM 108
           T  +E  +    R  W+SKL +IL+ VG++VGLGNVWRFPYL  +NGGGA+L+PYL++L 
Sbjct: 179 TQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLA 238

Query: 109 VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 168
           + G+P+FFLE+S+GQ   +G + VW  I P L G G A  ++   +A+YYNVII ++LFY
Sbjct: 239 LAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFY 297

Query: 169 FSQSFQQPLPWDQCPLVKNASHTFVEPECEQS---------------------------- 200
              SF   LPW  C      ++ +  PEC+                              
Sbjct: 298 LFASFVSVLPWGSC------NNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAY 351

Query: 201 -----------------SATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAM 243
                            S +  Y+    L IS+ I   G + W + +CL  AWV+V  ++
Sbjct: 352 PNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASL 411

Query: 244 IKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAA 303
            KGI++SGK++YF++ FPYVVL+  LIR   L G+  GI +  TPK E + +  VW++AA
Sbjct: 412 AKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAA 471

Query: 304 TQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 361
           TQ+FF+L   +GG+I  SSYNK  NNC+ D ++V+  N  TS+ A  V+F+V+GF AN
Sbjct: 472 TQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN 529



 Score =  151 bits (381), Expect = 2e-36
 Identities = 75/221 (33%), Positives = 128/221 (57%), Gaps = 17/221 (7%)

Query: 424 NSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIV 483
           N  K+  E N A QG G+AF+ + EA+T  P SPFW+++FFLML+ LGL +MF TIE IV
Sbjct: 529 NERKVNIE-NVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIV 587

Query: 484 TPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVIL 539
           T I D F    +  K + T+ CC+  F +G   + + G Y   + D Y+A+  L+I+ I 
Sbjct: 588 TSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIF 647

Query: 540 ENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGY 599
           E + + +VYG+ +F ED++ M+GF P+ ++   W +++P +L  +L  S       P  Y
Sbjct: 648 ELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQW--EPMTY 705

Query: 600 NAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
            ++           YP W +V+   ++  +++ +P++F+++
Sbjct: 706 GSY----------RYPNWSMVLGWLMLACSVIWIPIMFVIK 736


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  268 bits (686), Expect = 1e-71
 Identities = 124/308 (40%), Positives = 183/308 (59%), Gaps = 9/308 (2%)

Query: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119
           ER  WN+K++++L+  G  +GLGNVWRFPYLC KNGGGA+ +PYL+ L   GIP+F LE 
Sbjct: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90

Query: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179
           ++GQ   +G +  W  I P   GIG+AS ++   + +YY +++ W+LFY   SF   LPW
Sbjct: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150

Query: 180 DQCPLVKNASHTFVEPECEQS---------SATTYYWYREALNISSSISESGGLNWKMTI 230
             C    N  H     +   S         S    +W R  L IS  I   G L W++ +
Sbjct: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELAL 210

Query: 231 CLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKL 290
           CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR   L G+  GI+    P L
Sbjct: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNL 270

Query: 291 EIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATL 350
             + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D + + F+N  TS +A  
Sbjct: 271 TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGF 330

Query: 351 VVFAVLGF 358
            +F++LGF
Sbjct: 331 AIFSILGF 338



 Score =  120 bits (300), Expect = 6e-27
 Identities = 69/213 (32%), Positives = 117/213 (54%), Gaps = 18/213 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 490
           A  G GLAFIA+  A+   P SP W+  FF M+V LGL S F  +E +VT +VD +    
Sbjct: 351 AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVF 410

Query: 491 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547
             K R+E+L +   +++F +GLI +   G Y   +FD Y+A+ + LL V I E++ V +V
Sbjct: 411 RKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWV 470

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG  +F ++++DM+G+ P     Y W +++P +  +  + S++    +P  YN       
Sbjct: 471 YGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTYN------- 521

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
             +  +YP WG  +   L + +++ +P   + R
Sbjct: 522 --KKYTYPWWGDALGWLLALSSMVCIPAWSLYR 552


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  266 bits (679), Expect = 7e-71
 Identities = 127/334 (38%), Positives = 198/334 (59%), Gaps = 7/334 (2%)

Query: 35  KTSELIVDGQEEKDTDVEEGSEVED--ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQ 92
           + SE  V   + K   V+   +  D  +R  W  +  ++++ VG+++GLGNVWRFPYLC 
Sbjct: 16  EVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCG 75

Query: 93  KNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCY 152
           KNGGGA+L+PY + L+  G+PLF LE S+GQ    G +GVW  ++P   G+G A+ V+ +
Sbjct: 76  KNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSF 134

Query: 153 FVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTF----VEPECEQSSATTYYWY 208
           ++ +YY VII W+++Y   SF   LPW QC    N    F    +      +SA   +W 
Sbjct: 135 WLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWE 194

Query: 209 REALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICF 268
           R    ++  + + G + W + I L  AW++V   + KG+  +GK++YFS+ +PY++LI  
Sbjct: 195 RNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIIL 254

Query: 269 LIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDN 328
             R   L G+ +GI    TP    + + +VW +AATQ+FF+ GLG G +IA  SYN   N
Sbjct: 255 FFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHN 314

Query: 329 NCHFDAVLVSFINFFTSVLATLVVFAVLGFKANV 362
           N + D+++V  IN  TS+ A  V+F+++GF A+V
Sbjct: 315 NVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV 348



 Score =  125 bits (314), Expect = 1e-28
 Identities = 57/163 (34%), Positives = 103/163 (63%), Gaps = 5/163 (3%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 490
           A  G GLAF+A+ EA+T  P SP W+++FF ML+ LG+ S F T+EG +T +VD +    
Sbjct: 357 AASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLL 416

Query: 491 KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFVYG 549
           + R+E+     C++++ IGL  + + G Y   +FD YSA+ + LL +V  E +++ + YG
Sbjct: 417 RNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYG 476

Query: 550 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNM 592
           +++F +++++M+G  P  ++   W + +P+++  + I S V M
Sbjct: 477 VNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQM 519


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  259 bits (661), Expect = 8e-69
 Identities = 123/315 (39%), Positives = 186/315 (59%), Gaps = 17/315 (5%)

Query: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119
           ER  WN+K++++L+  G  +GLGNVWRFPYLC KNGGGA+L+PY++  +  GIP+FFLE 
Sbjct: 49  ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLET 108

Query: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179
           ++GQ    G I  W  + P   GIG+A+ V+   + +YY +I+ W++FY S  F   LPW
Sbjct: 109 ALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPW 168

Query: 180 DQCP--------------LVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLN 225
             C                V N SH  ++     +S    +W    L IS  I   G L 
Sbjct: 169 ATCGHEWNTENCVEFQKLNVSNYSHVSLQ---NATSPVMEFWEHRVLAISDGIEHIGNLR 225

Query: 226 WKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHM 285
           W++ +CLLAAW +    + KG +S+GK++Y ++ FPY++L+  LIR   L G+ +GI+  
Sbjct: 226 WELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFY 285

Query: 286 FTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTS 345
             P L  + +P+VW +A TQ+FF+  +  G + A  SYN  +NNC+ D +++  +N  TS
Sbjct: 286 LYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTS 345

Query: 346 VLATLVVFAVLGFKA 360
            +A   +F+VLGF A
Sbjct: 346 FVAGFAIFSVLGFMA 360



 Score =  121 bits (303), Expect = 3e-27
 Identities = 65/208 (31%), Positives = 115/208 (55%), Gaps = 18/208 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFK--- 491
           A  G GLAFIA+ +A+T  P SP W+ +FF+ML+ LGL S F  +E +VT +VD +    
Sbjct: 371 AESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVF 430

Query: 492 ---VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547
               R+E+L +   ++++ +GL+ +   G Y   +FD Y+A+ + LL V I E I + +V
Sbjct: 431 RRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWV 490

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG ++F ++++DM+G+ P     + W  ++P +   + I  ++     P  YN       
Sbjct: 491 YGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIK--YKPLKYN------- 541

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPV 635
                +YP WG  +   + + ++L +P+
Sbjct: 542 --NIYTYPAWGYGIGWLMALSSMLCIPL 567


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  256 bits (654), Expect = 5e-68
 Identities = 125/332 (37%), Positives = 191/332 (57%), Gaps = 31/332 (9%)

Query: 54  GSEVEDE-------RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLIL 106
           G+  EDE       R  W+SK+ ++L+  G  VGLGNVWRFPYLC KNGGGA+L+PY I 
Sbjct: 27  GTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 86

Query: 107 LMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSL 166
           L   G+P+FFLE+ +GQ    G I  W  I P   GIG+AS V+   + +YY VI+ W+ 
Sbjct: 87  LFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWAT 146

Query: 167 FYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SATTY------YWY 208
           +Y  QSFQ+ LPW  C      +H++  P C +             S+T +      +W 
Sbjct: 147 YYLFQSFQKELPWAHC------NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWE 200

Query: 209 REALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICF 268
           R  L++S  I   G L W + +CLL  W++    + KG++S+GK++YF++ FP+ +L+  
Sbjct: 201 RNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVL 260

Query: 269 LIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDN 328
           L+R   L G+  GI+    P +  + +P+VW +A TQ+FF+  +  G + +  SYNK   
Sbjct: 261 LVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKY 320

Query: 329 NCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 360
           N + D +L+  +N  TS ++   +F++LGF A
Sbjct: 321 NSYRDCMLLGCLNSGTSFVSGFAIFSILGFMA 352



 Score =  127 bits (319), Expect = 4e-29
 Identities = 72/213 (33%), Positives = 115/213 (53%), Gaps = 18/213 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFK--- 491
           A  G GLAFIA+ +A+T  P   FWS++FF+ML+ LGL S F  +EG +T +VD +    
Sbjct: 363 AESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFL 422

Query: 492 ---VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547
               R+EI     C +++ +GL  V   G Y   +FD Y+A+ + LL V   E   + ++
Sbjct: 423 RKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWI 482

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D   + ++DM+G+ P  +  Y W  I+P++ +   I S+V     P  YN       
Sbjct: 483 YGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVK--YVPLTYN------- 533

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
             +   YP W + +  SL + ++L VP+V ++R
Sbjct: 534 --KTYVYPNWAIGLGWSLALSSMLCVPLVIVIR 564


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  256 bits (654), Expect = 5e-68
 Identities = 125/332 (37%), Positives = 191/332 (57%), Gaps = 31/332 (9%)

Query: 54  GSEVEDE-------RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLIL 106
           G+  EDE       R  W+SK+ ++L+  G  VGLGNVWRFPYLC KNGGGA+L+PY I 
Sbjct: 27  GTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 86

Query: 107 LMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSL 166
           L   G+P+FFLE+ +GQ    G I  W  I P   GIG+AS V+   + +YY VI+ W+ 
Sbjct: 87  LFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWAT 146

Query: 167 FYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SATTY------YWY 208
           +Y  QSFQ+ LPW  C      +H++  P C +             S+T +      +W 
Sbjct: 147 YYLFQSFQKELPWAHC------NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWE 200

Query: 209 REALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICF 268
           R  L++S  I   G L W + +CLL  W++    + KG++S+GK++YF++ FP+ +L+  
Sbjct: 201 RNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVL 260

Query: 269 LIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDN 328
           L+R   L G+  GI+    P +  + +P+VW +A TQ+FF+  +  G + +  SYNK   
Sbjct: 261 LVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKY 320

Query: 329 NCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 360
           N + D +L+  +N  TS ++   +F++LGF A
Sbjct: 321 NSYRDCMLLGCLNSGTSFVSGFAIFSILGFMA 352



 Score =  127 bits (319), Expect = 4e-29
 Identities = 72/213 (33%), Positives = 115/213 (53%), Gaps = 18/213 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFK--- 491
           A  G GLAFIA+ +A+T  P   FWS++FF+ML+ LGL S F  +EG +T +VD +    
Sbjct: 363 AESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFL 422

Query: 492 ---VRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547
               R+EI     C +++ +GL  V   G Y   +FD Y+A+ + LL V   E   + ++
Sbjct: 423 RKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWI 482

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D   + ++DM+G+ P  +  Y W  I+P++ +   I S+V     P  YN       
Sbjct: 483 YGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVK--YVPLTYN------- 533

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640
             +   YP W + +  SL + ++L VP+V ++R
Sbjct: 534 --KTYVYPNWAIGLGWSLALSSMLCVPLVIVIR 564


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  200 bits (509), Expect = 3e-51
 Identities = 97/259 (37%), Positives = 149/259 (57%), Gaps = 30/259 (11%)

Query: 125 IRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPL 184
           ++ GSI VWN I P   G+G+AS V+ ++   YY +++ W  +Y  +SF   LPW  C  
Sbjct: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATC-- 57

Query: 185 VKNASHTFVEPEC-----------------------EQSSATTYYWYREALNISSSISES 221
                HT+  P+C                       ++ S    +W  + L +S  +   
Sbjct: 58  ----GHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVP 113

Query: 222 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 281
           G LNW++T+CLLA WV+V   + KG++S+GKI+YF++ FPYVVL+  L+R  LL G++DG
Sbjct: 114 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 173

Query: 282 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 341
           I +   P    +  P+VW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA++++ IN
Sbjct: 174 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN 233

Query: 342 FFTSVLATLVVFAVLGFKA 360
             TS  A  VVF++LGF A
Sbjct: 234 SGTSFFAGFVVFSILGFMA 252



 Score =  125 bits (315), Expect = 1e-28
 Identities = 71/208 (34%), Positives = 109/208 (52%), Gaps = 18/208 (8%)

Query: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489
           A  G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S F  +EG +T ++D      
Sbjct: 263 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 322

Query: 490 -FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547
            F+ ++EI   +CC L F I L  V   G Y   +FD YSA+   LL     E + V +V
Sbjct: 323 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 382

Query: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607
           YG D+FM+D+  M+G+ P  +  + W + +PL+ + + I +VV           + E   
Sbjct: 383 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV-----------YYEPLV 431

Query: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPV 635
                 YP WG  +  +  + ++L VP+
Sbjct: 432 YNNTYVYPWWGEAMGWAFALSSMLCVPL 459


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  148 bits (373), Expect = 2e-35
 Identities = 70/155 (45%), Positives = 95/155 (61%), Gaps = 13/155 (8%)

Query: 54  GSEVEDE-------RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLIL 106
           G+  EDE       R  W+SK+ ++L+  G  VGLGNVWRFPYLC KNGGGA+L+PY I 
Sbjct: 27  GTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 86

Query: 107 LMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSL 166
           L   G+P+FFLE+ +GQ    G I  W  I P   GIG+AS V+   + +YY VI+ W+ 
Sbjct: 87  LFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWAT 146

Query: 167 FYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSS 201
           +Y  QSFQ+ LPW  C      +H++  P C + +
Sbjct: 147 YYLFQSFQKELPWAHC------NHSWNTPHCMEDT 175


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,894,304
Number of Sequences: 37866
Number of extensions: 1214448
Number of successful extensions: 4454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 4277
Number of HSP's gapped (non-prelim): 85
length of query: 730
length of database: 18,247,518
effective HSP length: 110
effective length of query: 620
effective length of database: 14,082,258
effective search space: 8730999960
effective search space used: 8730999960
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.