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Search of human proteins with 32967599
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
(1001 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens] 2010 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 1197 0.0
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 956 0.0
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 947 0.0
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 848 0.0
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 775 0.0
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 775 0.0
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 775 0.0
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 775 0.0
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 742 0.0
gi|61742784 leucine rich repeat and death domain containing prot... 90 9e-18
gi|61742786 leucine rich repeat and death domain containing prot... 89 2e-17
gi|61742782 leucine rich repeat and death domain containing prot... 86 2e-16
gi|218563746 hypothetical protein LOC401124 [Homo sapiens] 60 1e-08
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 49 3e-05
gi|114431248 hypothetical protein LOC205717 [Homo sapiens] 42 0.003
gi|27734865 unc-5 homolog C-like [Homo sapiens] 41 0.005
gi|4505229 Fas-associated via death domain [Homo sapiens] 37 0.071
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 37 0.071
gi|6754638 microtubule-associated protein tau isoform 2 [Homo sa... 37 0.093
gi|4503337 dyskerin isoform 1 [Homo sapiens] 37 0.12
gi|221139728 pleckstrin homology domain containing, family M (wi... 37 0.12
gi|21361086 tumor necrosis factor receptor superfamily, member 1... 36 0.16
gi|78482627 ring finger protein 30 isoform 1 [Homo sapiens] 36 0.16
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 36 0.21
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 36 0.21
gi|4505393 nerve growth factor receptor precursor [Homo sapiens] 35 0.27
gi|118498362 kinectin 1 isoform b [Homo sapiens] 35 0.35
gi|87299628 biorientation of chromosomes in cell division 1-like... 35 0.35
gi|62241003 cardiomyopathy associated 5 [Homo sapiens] 35 0.46
>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
Length = 1001
Score = 2010 bits (5207), Expect = 0.0
Identities = 1001/1001 (100%), Positives = 1001/1001 (100%)
Query: 1 MALPQSEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLN 60
MALPQSEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLN
Sbjct: 1 MALPQSEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLN 60
Query: 61 RSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLV 120
RSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLV
Sbjct: 61 RSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLV 120
Query: 121 SFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRL 180
SFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRL
Sbjct: 121 SFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRL 180
Query: 181 VEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNG 240
VEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNG
Sbjct: 181 VEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNG 240
Query: 241 MDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASF 300
MDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASF
Sbjct: 241 MDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASF 300
Query: 301 PEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPS 360
PEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPS
Sbjct: 301 PEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPS 360
Query: 361 GEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLA 420
GEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLA
Sbjct: 361 GEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLA 420
Query: 421 DCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQE 480
DCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQE
Sbjct: 421 DCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQE 480
Query: 481 NFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQ 540
NFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQ
Sbjct: 481 NFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQ 540
Query: 541 EPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEP 600
EPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEP
Sbjct: 541 EPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEP 600
Query: 601 GMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLK 660
GMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLK
Sbjct: 601 GMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLK 660
Query: 661 KWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDG 720
KWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDG
Sbjct: 661 KWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDG 720
Query: 721 YPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSAD 780
YPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSAD
Sbjct: 721 YPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSAD 780
Query: 781 GPPVVTAEDASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQAR 840
GPPVVTAEDASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQAR
Sbjct: 781 GPPVVTAEDASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQAR 840
Query: 841 RVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGK 900
RVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGK
Sbjct: 841 RVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGK 900
Query: 901 QSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPAD 960
QSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPAD
Sbjct: 901 QSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPAD 960
Query: 961 GKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 1001
GKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS
Sbjct: 961 GKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 1001
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 1197 bits (3096), Expect = 0.0
Identities = 597/611 (97%), Positives = 599/611 (98%), Gaps = 9/611 (1%)
Query: 5 QSEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSY 64
+ EDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSY
Sbjct: 871 EGEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSY 930
Query: 65 ARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMV 124
ARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMV
Sbjct: 931 ARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMV 990
Query: 125 DARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMG 184
DARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMG
Sbjct: 991 DARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMG 1050
Query: 185 PAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEE 244
PAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEE
Sbjct: 1051 PAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEE 1110
Query: 245 LDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA 304
LDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA
Sbjct: 1111 LDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA 1170
Query: 305 LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV 364
LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV
Sbjct: 1171 LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV 1230
Query: 365 SNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQ 424
SNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQ
Sbjct: 1231 SNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQ 1290
Query: 425 VLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE 484
VLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE
Sbjct: 1291 VLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE 1350
Query: 485 VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCG 544
VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCG
Sbjct: 1351 VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCG 1410
Query: 545 RLSFLKEPKTTKGLPQTAVCNLNITLPAHKK---------IEKTDRRQSFASLALRKRYS 595
RLSFLKEPKTTKGLPQTAVCNLNITLPAHKK IEKTDRRQSFASLALRKRYS
Sbjct: 1411 RLSFLKEPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYS 1470
Query: 596 YLTEPGMSPQS 606
YLTEPGM +S
Sbjct: 1471 YLTEPGMIERS 1481
Score = 360 bits (924), Expect = 4e-99
Identities = 178/178 (100%), Positives = 178/178 (100%)
Query: 824 WQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITP 883
WQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITP
Sbjct: 4200 WQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITP 4259
Query: 884 EAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETK 943
EAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETK
Sbjct: 4260 EAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETK 4319
Query: 944 PCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 1001
PCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS
Sbjct: 4320 PCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 4377
Score = 239 bits (611), Expect = 7e-63
Identities = 124/148 (83%), Positives = 126/148 (85%), Gaps = 4/148 (2%)
Query: 574 KKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTELAREL 633
KK E + KR S T PQSPCERTDIRMAIVADHLGLSWTELAREL
Sbjct: 4057 KKTEAAPLKSKSEKAGSEKRSSRRT----GPQSPCERTDIRMAIVADHLGLSWTELAREL 4112
Query: 634 NFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEG 693
NFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEG
Sbjct: 4113 NFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEG 4172
Query: 694 PIFDYGNISGTRSFADENNVFHDPVDGY 721
PIFDYGNISGTRSFADENNVFHDPVDG+
Sbjct: 4173 PIFDYGNISGTRSFADENNVFHDPVDGW 4200
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 956 bits (2471), Expect = 0.0
Identities = 532/997 (53%), Positives = 662/997 (66%), Gaps = 116/997 (11%)
Query: 5 QSEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRSFSSDRSY 57
+ +D MTGD +YL P+DLKELGDDSLP+ Y+ +SL G RS SLRSFSSDRS+
Sbjct: 849 EGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSH 908
Query: 58 TLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSG 117
TL+ +SY RDS ++++ +V Q T +E + +S R SW + LDNV L SSPIHSG
Sbjct: 909 TLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALSSSPIHSG 967
Query: 118 FLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLA 177
FLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA PPMVEGEGLA
Sbjct: 968 FLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLA 1027
Query: 178 SRLVEMGPAGAQFLG---------------------------------PVIVEIPHFGSM 204
SRL+E+GP+GAQFLG PVIVEIPHF ++
Sbjct: 1028 SRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAAL 1087
Query: 205 RGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDF 264
RGKEREL+VLRSENG++WKEH D ++L E+LNGMDE LDSPE+L KKRICRIIT+DF
Sbjct: 1088 RGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDF 1147
Query: 265 PQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVK 324
PQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVGLQAQP+ E+VK
Sbjct: 1148 PQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVK 1207
Query: 325 KILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITG 384
KILGNKATFSPIVT+EPRRRKFHKPITMTIPVP S + + NG+ GD P LRLLCSITG
Sbjct: 1208 KILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA-PTLRLLCSITG 1266
Query: 385 GTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPY 444
GT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V A+Q+YRE+ICVPY
Sbjct: 1267 GTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPY 1326
Query: 445 MAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCY 504
MAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+EVLEGKPIYVDC+
Sbjct: 1327 MAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCF 1386
Query: 505 GNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVC 564
GNL PLTK GQ +F+F++FKENRLP +K+RDT+QEPCGRLSF+KEPK+T+GL A+C
Sbjct: 1387 GNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAIC 1446
Query: 565 NLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGL 624
NLNITLP + K ++D+ Q + +E +PQ ER + R+A +ADHLG
Sbjct: 1447 NLNITLPIYTKESESDQEQ-------EEEIDMTSE--KNPQDEQERIEERLAYIADHLGF 1497
Query: 625 SWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINR 684
SWTELAREL+F+ ++I+QIR+ENPNSL QS LLK W+ RDGK+AT L LTKINR
Sbjct: 1498 SWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINR 1557
Query: 685 IDIVTLLE---GPIFDYGNISGTRSFAD-ENNVFHDPVDGYPSLQVELETPTGLHYTPPT 740
+DIV L+E P+ + IS S+A+ E + D +G+ LQ EL T
Sbjct: 1558 MDIVHLMETNTEPLQE--RIS--HSYAEIEQTITLDHSEGFSVLQEELCTA--------- 1604
Query: 741 PFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDS 800
Q S ES + D PP+V+ ED S+ S +D
Sbjct: 1605 --QHKQKEEQAVSKES--------------------ETCDHPPIVSEEDISVGYSTFQDG 1642
Query: 801 VPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCR-D 859
VP TE ++S+ L +V ++ D P++ +
Sbjct: 1643 VPKTE--------------------GDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLE 1682
Query: 860 SITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKP---KIHGSGH 916
Y G + I P + +K+ PE + ++ P + GS
Sbjct: 1683 YQQEYFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTPAEEEKLYLQTPTSSERGGSPI 1740
Query: 917 VEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKM 953
++EP P ++S + L+I E+ P + +++
Sbjct: 1741 IQEPEEPSEHREESSPRKTSLVIVESADNQPETCERL 1777
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 947 bits (2448), Expect = 0.0
Identities = 532/1009 (52%), Positives = 662/1009 (65%), Gaps = 128/1009 (12%)
Query: 5 QSEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRSFSSDRSY 57
+ +D MTGD +YL P+DLKELGDDSLP+ Y+ +SL G RS SLRSFSSDRS+
Sbjct: 828 EGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSH 887
Query: 58 TLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSG 117
TL+ +SY RDS ++++ +V Q T +E + +S R SW + LDNV L SSPIHSG
Sbjct: 888 TLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALSSSPIHSG 946
Query: 118 ------------FLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLA 165
FLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA
Sbjct: 947 RASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLA 1006
Query: 166 NPPPMVEGEGLASRLVEMGPAGAQFLG--------------------------------- 192
PPMVEGEGLASRL+E+GP+GAQFLG
Sbjct: 1007 TMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLG 1066
Query: 193 PVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELG 252
PVIVEIPHF ++RGKEREL+VLRSENG++WKEH D ++L E+LNGMDE LDSPE+L
Sbjct: 1067 PVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLE 1126
Query: 253 KKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVG 312
KKRICRIIT+DFPQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVG
Sbjct: 1127 KKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVG 1186
Query: 313 LQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDT 372
LQAQP+ E+VKKILGNKATFSPIVT+EPRRRKFHKPITMTIPVP S + + NG+ GD
Sbjct: 1187 LQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA 1246
Query: 373 TPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLA 432
P LRLLCSITGGT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V A
Sbjct: 1247 -PTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFA 1305
Query: 433 TQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIE 492
+Q+YRE+ICVPYMAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+E
Sbjct: 1306 SQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVE 1365
Query: 493 VLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEP 552
VLEGKPIYVDC+GNL PLTK GQ +F+F++FKENRLP +K+RDT+QEPCGRLSF+KEP
Sbjct: 1366 VLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEP 1425
Query: 553 KTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTD 612
K+T+GL A+CNLNITLP + K ++D+ Q + +E +PQ ER +
Sbjct: 1426 KSTRGLVHQAICNLNITLPIYTKESESDQEQ-------EEEIDMTSE--KNPQDEQERIE 1476
Query: 613 IRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATT 672
R+A +ADHLG SWTELAREL+F+ ++I+QIR+ENPNSL QS LLK W+ RDGK+AT
Sbjct: 1477 ERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATD 1536
Query: 673 DALTSVLTKINRIDIVTLLE---GPIFDYGNISGTRSFAD-ENNVFHDPVDGYPSLQVEL 728
L LTKINR+DIV L+E P+ + IS S+A+ E + D +G+ LQ EL
Sbjct: 1537 TNLVECLTKINRMDIVHLMETNTEPLQE--RIS--HSYAEIEQTITLDHSEGFSVLQEEL 1592
Query: 729 ETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAE 788
T Q S ES + D PP+V+ E
Sbjct: 1593 CTA-----------QHKQKEEQAVSKES--------------------ETCDHPPIVSEE 1621
Query: 789 DASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLD 848
D S+ S +D VP TE ++S+ L +V
Sbjct: 1622 DISVGYSTFQDGVPKTE--------------------GDSSATALFPQTHKEQVQQDFSG 1661
Query: 849 RLDDSPDQCR-DSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETL 907
++ D P++ + Y G + I P + +K+ PE + ++
Sbjct: 1662 KMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTPAEEEKLYLQ 1719
Query: 908 KP---KIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKM 953
P + GS ++EP P ++S + L+I E+ P + +++
Sbjct: 1720 TPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERL 1768
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 848 bits (2192), Expect = 0.0
Identities = 423/619 (68%), Positives = 497/619 (80%), Gaps = 42/619 (6%)
Query: 5 QSEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRSFSSDRSY 57
+ +D MTGD +YL P+DLKELGDDSLP+ Y+ +SL G RS SLRSFSSDRS+
Sbjct: 849 EGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSH 908
Query: 58 TLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSG 117
TL+ +SY RDS ++++ +V Q T +E + +S R SW + LDNV L SSPIHSG
Sbjct: 909 TLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALSSSPIHSG 967
Query: 118 FLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLA 177
FLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA PPMVEGEGLA
Sbjct: 968 FLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLA 1027
Query: 178 SRLVEMGPAGAQFLG---------------------------------PVIVEIPHFGSM 204
SRL+E+GP+GAQFLG PVIVEIPHF ++
Sbjct: 1028 SRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAAL 1087
Query: 205 RGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDF 264
RGKEREL+VLRSENG++WKEH D ++L E+LNGMDE LDSPE+L KKRICRIIT+DF
Sbjct: 1088 RGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDF 1147
Query: 265 PQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVK 324
PQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVGLQAQP+ E+VK
Sbjct: 1148 PQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVK 1207
Query: 325 KILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITG 384
KILGNKATFSPIVT+EPRRRKFHKPITMTIPVP S + + NG+ GD P LRLLCSITG
Sbjct: 1208 KILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA-PTLRLLCSITG 1266
Query: 385 GTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPY 444
GT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V A+Q+YRE+ICVPY
Sbjct: 1267 GTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPY 1326
Query: 445 MAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCY 504
MAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+EVLEGKPIYVDC+
Sbjct: 1327 MAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCF 1386
Query: 505 GNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVC 564
GNL PLTK GQ +F+F++FKENRLP +K+RDT+QEPCGRLSF+KEPK+T+GL A+C
Sbjct: 1387 GNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAIC 1446
Query: 565 NLNITLPAHKKIEKTDRRQ 583
NLNITLP + K ++D+ Q
Sbjct: 1447 NLNITLPIYTKESESDQEQ 1465
Score = 125 bits (315), Expect = 2e-28
Identities = 138/527 (26%), Positives = 220/527 (41%), Gaps = 92/527 (17%)
Query: 458 VESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEV-----------LEGKPIYVDCYGN 506
++S +C T + E +E EE+ + ++ + C G
Sbjct: 3397 LDSKTKCPVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGG 3456
Query: 507 LAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLS-------FLKEPKTTKGLP 559
+P TK ++ F+ Y N + F +I D + + RL+ + + +++ L
Sbjct: 3457 TSP-TKESKEHFFDLY---RNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALE 3512
Query: 560 QTAVCNLNITLPAHKKIEKT-DRR----QSFASLALRKRYSYLTEPGMSPQSPCERTDIR 614
+ + NL H E D R +S +L R + PQ ER + R
Sbjct: 3513 VSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEER 3572
Query: 615 MAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDA 674
+A +ADHLG SWTELAREL+F+ ++I+QIR+ENPNSL QS LLK W+ RDGK+AT
Sbjct: 3573 LAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTN 3632
Query: 675 LTSVLTKINRIDIVTLLE---GPIFDYGNISGTRSFAD-ENNVFHDPVDGYPSLQVELET 730
L LTKINR+DIV L+E P+ + IS S+A+ E + D +G+ LQ EL T
Sbjct: 3633 LVECLTKINRMDIVHLMETNTEPLQE--RIS--HSYAEIEQTITLDHSEGFSVLQEELCT 3688
Query: 731 PTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDA 790
Q S ES + D PP+V+ ED
Sbjct: 3689 A-----------QHKQKEEQAVSKES--------------------ETCDHPPIVSEEDI 3717
Query: 791 SLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRL 850
S+ S +D VP TE ++S+ L +V ++
Sbjct: 3718 SVGYSTFQDGVPKTE--------------------GDSSATALFPQTHKEQVQQDFSGKM 3757
Query: 851 DDSPDQCR-DSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKP 909
D P++ + Y G + I P + +K+ PE + ++ P
Sbjct: 3758 QDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKT--PEEVSTPAEEEKLYLQTP 3815
Query: 910 ---KIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKM 953
+ GS ++EP P ++S + L+I E+ P + +++
Sbjct: 3816 TSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERL 3862
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 775 bits (2001), Expect = 0.0
Identities = 405/733 (55%), Positives = 523/733 (71%), Gaps = 7/733 (0%)
Query: 70 MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129
M E +++ S+EQ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 907 MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 965
Query: 130 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189
SMRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 966 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 1025
Query: 190 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249
FL PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S E
Sbjct: 1026 FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1085
Query: 250 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309
EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+
Sbjct: 1086 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1145
Query: 310 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369
++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +
Sbjct: 1146 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1205
Query: 370 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429
GDTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 1206 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1264
Query: 430 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 1265 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1324
Query: 490 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549
DIEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL
Sbjct: 1325 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1384
Query: 550 KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608
++ + Q +C+LNIT+ P K DRR++ LAL RYS L+E S
Sbjct: 1385 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1441
Query: 609 ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668
E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+
Sbjct: 1442 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1501
Query: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727
NA + L + L I+R +IV +LEG N+ R D + ++ ++GY SLQ E
Sbjct: 1502 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1561
Query: 728 LETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTA 787
L +P L +P + D Y+++++ +++ + L S + + P +VTA
Sbjct: 1562 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1621
Query: 788 EDASLEDSKLEDS 800
ED+SLE SK EDS
Sbjct: 1622 EDSSLECSKAEDS 1634
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 775 bits (2001), Expect = 0.0
Identities = 405/733 (55%), Positives = 523/733 (71%), Gaps = 7/733 (0%)
Query: 70 MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129
M E +++ S+EQ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 866 MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 924
Query: 130 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189
SMRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 925 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 984
Query: 190 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249
FL PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S E
Sbjct: 985 FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1044
Query: 250 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309
EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+
Sbjct: 1045 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1104
Query: 310 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369
++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +
Sbjct: 1105 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1164
Query: 370 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429
GDTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 1165 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1223
Query: 430 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 1224 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1283
Query: 490 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549
DIEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL
Sbjct: 1284 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1343
Query: 550 KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608
++ + Q +C+LNIT+ P K DRR++ LAL RYS L+E S
Sbjct: 1344 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1400
Query: 609 ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668
E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
Query: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727
NA + L + L I+R +IV +LEG N+ R D + ++ ++GY SLQ E
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520
Query: 728 LETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTA 787
L +P L +P + D Y+++++ +++ + L S + + P +VTA
Sbjct: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580
Query: 788 EDASLEDSKLEDS 800
ED+SLE SK EDS
Sbjct: 1581 EDSSLECSKAEDS 1593
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 775 bits (2001), Expect = 0.0
Identities = 405/733 (55%), Positives = 523/733 (71%), Gaps = 7/733 (0%)
Query: 70 MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129
M E +++ S+EQ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 866 MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 924
Query: 130 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189
SMRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 925 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 984
Query: 190 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249
FL PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S E
Sbjct: 985 FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1044
Query: 250 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309
EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+
Sbjct: 1045 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1104
Query: 310 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369
++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +
Sbjct: 1105 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1164
Query: 370 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429
GDTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 1165 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1223
Query: 430 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 1224 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1283
Query: 490 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549
DIEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL
Sbjct: 1284 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1343
Query: 550 KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608
++ + Q +C+LNIT+ P K DRR++ LAL RYS L+E S
Sbjct: 1344 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1400
Query: 609 ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668
E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
Query: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727
NA + L + L I+R +IV +LEG N+ R D + ++ ++GY SLQ E
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520
Query: 728 LETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTA 787
L +P L +P + D Y+++++ +++ + L S + + P +VTA
Sbjct: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580
Query: 788 EDASLEDSKLEDS 800
ED+SLE SK EDS
Sbjct: 1581 EDSSLECSKAEDS 1593
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 775 bits (2001), Expect = 0.0
Identities = 405/733 (55%), Positives = 523/733 (71%), Gaps = 7/733 (0%)
Query: 70 MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129
M E +++ S+EQ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 866 MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 924
Query: 130 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189
SMRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 925 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 984
Query: 190 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249
FL PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S E
Sbjct: 985 FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1044
Query: 250 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309
EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+
Sbjct: 1045 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1104
Query: 310 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369
++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +
Sbjct: 1105 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1164
Query: 370 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429
GDTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 1165 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1223
Query: 430 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 1224 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1283
Query: 490 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549
DIEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL
Sbjct: 1284 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1343
Query: 550 KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608
++ + Q +C+LNIT+ P K DRR++ LAL RYS L+E S
Sbjct: 1344 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1400
Query: 609 ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668
E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
Query: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727
NA + L + L I+R +IV +LEG N+ R D + ++ ++GY SLQ E
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520
Query: 728 LETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTA 787
L +P L +P + D Y+++++ +++ + L S + + P +VTA
Sbjct: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580
Query: 788 EDASLEDSKLEDS 800
ED+SLE SK EDS
Sbjct: 1581 EDSSLECSKAEDS 1593
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 742 bits (1915), Expect = 0.0
Identities = 405/749 (54%), Positives = 520/749 (69%), Gaps = 17/749 (2%)
Query: 70 MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129
M E +++ S+EQ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 866 MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 924
Query: 130 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189
SMRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 925 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 984
Query: 190 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249
FL PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S E
Sbjct: 985 FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1044
Query: 250 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309
EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+
Sbjct: 1045 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1104
Query: 310 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369
++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +
Sbjct: 1105 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1164
Query: 370 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429
GDTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 1165 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1223
Query: 430 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 1224 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1283
Query: 490 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549
DIEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL
Sbjct: 1284 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1343
Query: 550 KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608
++ + Q +C+LNIT+ P K DRR++ LAL RYS L+E S
Sbjct: 1344 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1400
Query: 609 ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668
E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+
Sbjct: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
Query: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727
NA + L + L I+R +IV +LEG N+ R D + ++ ++G+ Q
Sbjct: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGHQRGQAR 1520
Query: 728 L-ETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVT 786
+ +PT T + + D+ +D SI S L+ ++ S +QG HS G +T
Sbjct: 1521 ITHSPTVSQVTERSQDRLQDWDAD-GSIVSYLQDAAQGSWQEEVTQG--PHSFQGTSTMT 1577
Query: 787 ---AEDASLEDSKLEDSV---PLTEMPEA 809
S E K+ SV TE PEA
Sbjct: 1578 EGLEPGGSQEYEKVLVSVSEHTWTEQPEA 1606
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 90.1 bits (222), Expect = 9e-18
Identities = 144/599 (24%), Positives = 242/599 (40%), Gaps = 86/599 (14%)
Query: 119 LVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPP--PMVEGEGL 176
L SF V +G S+ + G+R+ P P I RL+ L P P+ + L
Sbjct: 323 LDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIRYRLL----LPEPGLVPLGPHDAL 376
Query: 177 ASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTE 236
S ++E+ P G F V + + + RE++V R+ N +W DL
Sbjct: 377 LSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-RTRNDNSWG---------DLET 426
Query: 237 LLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLV 296
L E ++P+ L C++ +F VVSR + + PEG +L S+ P V
Sbjct: 427 YL-----EEEAPQRLWAH--CQV---PHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGV 476
Query: 297 QASFPEGALTKRIRVGLQAQPVPDEIVKKILGN-KATFSPIVTV-EPRRRKFHKPITMTI 354
+ FP GA + RV +Q + ++ +LG +A SP++ + + F +P+T+ +
Sbjct: 477 KVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQL 536
Query: 355 PVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVS 414
P+P +G G + RL + A W+DIT L F
Sbjct: 537 PLP--------SGITGLSLDRSRLHL-LYWAPPAATWDDITAQVVLELTHLYARFQVTHF 587
Query: 415 ARFWL----ADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDD 470
+ +WL +C GLA + + L + + + DP + L+ C+ +
Sbjct: 588 SWYWLWYTTKNC-----VGGLARKAWERLRL--HRVNLIALQRRRDPEQVLLQ--CLPRN 638
Query: 471 KVDKTLEQ-QENFEEVARSKDIEVLEGKPIY------VDCYGNLAPLTKGGQQLVFNFYS 523
KVD TL + E + S +E+ EG+ + +D + +G ++ F FYS
Sbjct: 639 KVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEG--RICFVFYS 696
Query: 524 FKEN--RLPFSIKIRDTSQEPCGRLSFLK------------EPKTTKGLPQTAVCNLNIT 569
+N + + + +Q G++SF + + KG + L I
Sbjct: 697 HLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIK 756
Query: 570 LPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTEL 629
LP ++ ++ + A L+L E G QS + VA LGL W +
Sbjct: 757 LP---RLRGSEGPRRGAGLSLAPLNLGDAETGFLTQS-------NLLSVAGRLGLDWPAV 806
Query: 630 ARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRD-GKNATTDALTSVLTKINRIDI 687
A L S E+ +IR E + L Q +L W R G+ L L + +R D+
Sbjct: 807 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDV 865
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 89.0 bits (219), Expect = 2e-17
Identities = 143/590 (24%), Positives = 236/590 (40%), Gaps = 85/590 (14%)
Query: 119 LVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPP--PMVEGEGL 176
L SF V +G S+ + G+R+ P P I RL+ L P P+ + L
Sbjct: 323 LDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIRYRLL----LPEPGLVPLGPHDAL 376
Query: 177 ASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTE 236
S ++E+ P G F V + + + RE++V R+ N +W DL
Sbjct: 377 LSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-RTRNDNSWG---------DLET 426
Query: 237 LLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLV 296
L E ++P+ L C++ +F VVSR + + PEG +L S+ P V
Sbjct: 427 YL-----EEEAPQRLWAH--CQV---PHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGV 476
Query: 297 QASFPEGALTKRIRVGLQAQPVPDEIVKKILGN-KATFSPIVTV-EPRRRKFHKPITMTI 354
+ FP GA + RV +Q + ++ +LG +A SP++ + + F +P+T+ +
Sbjct: 477 KVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQL 536
Query: 355 PVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVS 414
P+P +G G + RL + A W+DIT L F
Sbjct: 537 PLP--------SGITGLSLDRSRLHL-LYWAPPAATWDDITAQVVLELTHLYARFQVTHF 587
Query: 415 ARFWL----ADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDD 470
+ +WL +C GLA + + L + + + DP + L+ C+ +
Sbjct: 588 SWYWLWYTTKNC-----VGGLARKAWERLRL--HRVNLIALQRRRDPEQVLLQ--CLPRN 638
Query: 471 KVDKTLEQ-QENFEEVARSKDIEVLEGKPIY------VDCYGNLAPLTKGGQQLVFNFYS 523
KVD TL + E + S +E+ EG+ + +D + +G ++ F FYS
Sbjct: 639 KVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEG--RICFVFYS 696
Query: 524 FKENRLPFS-----IKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKIEK 578
+N S + +R + R KG + L I LP ++
Sbjct: 697 HLKNVKEVSFYRGAVPVRVPEEAEAAR--------QRKGADALWMATLPIKLP---RLRG 745
Query: 579 TDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVD 638
++ + A L+L E G QS + VA LGL W +A L S
Sbjct: 746 SEGPRRGAGLSLAPLNLGDAETGFLTQS-------NLLSVAGRLGLDWPAVALHLGVSYR 798
Query: 639 EINQIRVENPNSLISQSFMLLKKWVTRD-GKNATTDALTSVLTKINRIDI 687
E+ +IR E + L Q +L W R G+ L L + +R D+
Sbjct: 799 EVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDV 848
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 85.5 bits (210), Expect = 2e-16
Identities = 143/599 (23%), Positives = 242/599 (40%), Gaps = 97/599 (16%)
Query: 119 LVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPP--PMVEGEGL 176
L SF V +G S+ + G+R+ P P I RL+ L P P+ + L
Sbjct: 177 LDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIRYRLL----LPEPGLVPLGPHDAL 230
Query: 177 ASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTE 236
S ++E+ P G F V + + + RE++V R+ N +W DL
Sbjct: 231 LSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-RTRNDNSWG---------DLET 280
Query: 237 LLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLV 296
L E ++P+ L C++ +F VVSR + + PEG +L S+ P V
Sbjct: 281 YL-----EEEAPQRLWAH--CQV---PHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGV 330
Query: 297 QASFPEGALTKRIRVGLQAQPVPDEIVKKILGN-KATFSPIVTV-EPRRRKFHKPITMTI 354
+ FP GA + RV +Q + ++ +LG +A SP++ + + F +P+T+ +
Sbjct: 331 KVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQL 390
Query: 355 PVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVS 414
P+P +G G + RL + A W+DIT L ++
Sbjct: 391 PLP--------SGITGLSLDRSRLHL-LYWAPPAATWDDITAQVVL-----------ELT 430
Query: 415 ARFWL----ADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDD 470
+WL +C GLA + + L + + + DP + L+ C+ +
Sbjct: 431 HLYWLWYTTKNC-----VGGLARKAWERLRL--HRVNLIALQRRRDPEQVLLQ--CLPRN 481
Query: 471 KVDKTLEQ-QENFEEVARSKDIEVLEGKPIY------VDCYGNLAPLTKGGQQLVFNFYS 523
KVD TL + E + S +E+ EG+ + +D + +G ++ F FYS
Sbjct: 482 KVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEG--RICFVFYS 539
Query: 524 FKEN--RLPFSIKIRDTSQEPCGRLSFLK------------EPKTTKGLPQTAVCNLNIT 569
+N + + + +Q G++SF + + KG + L I
Sbjct: 540 HLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIK 599
Query: 570 LPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTEL 629
LP ++ ++ + A L+L E G QS + VA LGL W +
Sbjct: 600 LP---RLRGSEGPRRGAGLSLAPLNLGDAETGFLTQS-------NLLSVAGRLGLDWPAV 649
Query: 630 ARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRD-GKNATTDALTSVLTKINRIDI 687
A L S E+ +IR E + L Q +L W R G+ L L + +R D+
Sbjct: 650 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDV 708
>gi|218563746 hypothetical protein LOC401124 [Homo sapiens]
Length = 616
Score = 60.1 bits (144), Expect = 1e-08
Identities = 117/517 (22%), Positives = 200/517 (38%), Gaps = 106/517 (20%)
Query: 268 FAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKIL 327
F+VVS +K+ES + +G L S+ + ++P G T + V L+ QPV +V +
Sbjct: 130 FSVVSCLKKESFTVTKKGLALKSSMDSRISLNYPPGVFTSPVLVQLKIQPVDPALVAHLK 189
Query: 328 GNKATF------SPIVTVE-PRRRKFHKPITMTIPVPP-----PSGEGVSNGYKGDTTPN 375
+ TF SP++ ++ P F KP+T+ +P P G + + + T N
Sbjct: 190 AQQDTFYSVQSTSPLIHIQHPSTYPFQKPVTLFLPCSPYLDKNNLGSEIDHKRRASATIN 249
Query: 376 LRLLCSITGGTSPAQWEDITGTTPLTFIKDC---VSFTTNVSARFWLADCHQVLETVGLA 432
R+ S T A P +C + F + S L D + +++ ++
Sbjct: 250 -RITPSYFNRTKIASIR-----KPRKNASECLKLLGFRSQDSGWCGLDDVVKTIQSGLVS 303
Query: 433 TQLYREL--ICVPYMAK------FVVFAK-MNDPVESSLRCFCMTDDK-----VDKTLEQ 478
+LY L V +++ V F K + + + S+ C ++ K + +
Sbjct: 304 VELYEHLERFIVLHLSSTMDNSHLVTFVKSLEEAMLSTTACIVLSHQKDNPHRIAVLVVP 363
Query: 479 QENFEEVAR-------------SKDIEVLEGKPIYVDCYGNLAPLTKG---GQQLVFNFY 522
++ +V + S+ +V EG+ + + GN+ + G G+ F+
Sbjct: 364 SKDLSQVLKDLHLEGFGGPPEPSRHFQVREGEQLLLRFTGNIFASSNGKDYGKDYTLIFH 423
Query: 523 SFKENRLPFSIK-IRDTSQEPC----GRLSFLKEPK------------TTKGLPQTAVCN 565
++ RL IK + + C G + K PK + Q +C
Sbjct: 424 LQRKPRLELQIKEVDEFGNYSCPHYKGTIVVYKVPKGKIVPNLNQSLVINENHSQLPICK 483
Query: 566 LNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERT-DIRMAIVADHLGL 624
L + LP HKK+ +R QS KR S + P E D + +A+ L
Sbjct: 484 LPLKLPKHKKL--INRPQS------TKRVS---------KDPVEALWDNLLHWLAEELSE 526
Query: 625 SWTE-LARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSV---LT 680
E L+ L I I+++NP+ L Q L W + TD L + L
Sbjct: 527 ENAESLSSTLPLRRSTIQLIKLKNPDDLTEQIHEFLCFW--KKSLPTFTDKLRLLARHLR 584
Query: 681 KINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDP 717
KI R D+ L+ F EN VF +P
Sbjct: 585 KIGRSDLAEELK--------------FKWENKVFTEP 607
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 48.5 bits (114), Expect = 3e-05
Identities = 39/152 (25%), Positives = 73/152 (48%), Gaps = 9/152 (5%)
Query: 546 LSFLKEPKTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQ 605
+ F P T + + T + I + A+ +E + +SL ++ EP Q
Sbjct: 517 MPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGG---TSSSLLDSTNTNFKEEPAAKYQ 573
Query: 606 SPCERT----DIRMAIVADHLGLSWTELARELNFSVDEINQIRVE-NPNSLISQSFMLLK 660
+ + T D + + ++LG W AR+L F+ +I++I + + L + + +L+
Sbjct: 574 AIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQ 633
Query: 661 KWVTRDG-KNATTDALTSVLTKINRIDIVTLL 691
KWV R+G K AT L L + +RID+++ L
Sbjct: 634 KWVMREGIKGATVGKLAQALHQCSRIDLLSSL 665
>gi|114431248 hypothetical protein LOC205717 [Homo sapiens]
Length = 2245
Score = 42.0 bits (97), Expect = 0.003
Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 9/126 (7%)
Query: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSF--ADENNVFHDP-----VDGY 721
NATT+ S T + + DIV L IFD N+ R AD V P ++G
Sbjct: 1115 NATTNTCDSC-TFVEQTDIVALAARAIFDQENLEKGRVGLQADIREVASKPSEASLLEGD 1173
Query: 722 PSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADG 781
P + ++ +G TP + + S +++E PL PS S G+ S +++ S
Sbjct: 1174 PPFKSQIPKESGTGQAEATPNEFNSQGSIEATMERPLEKPS-CSLGIKTSNASLQDSTSQ 1232
Query: 782 PPVVTA 787
PP +T+
Sbjct: 1233 PPSITS 1238
>gi|27734865 unc-5 homolog C-like [Homo sapiens]
Length = 518
Score = 41.2 bits (95), Expect = 0.005
Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 1/77 (1%)
Query: 124 VDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEM 183
VD RGG + + G+ ++IPP + L+ L++ P + + +GL S +V
Sbjct: 108 VDHRGGCLM-LQDTGISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSQAQGLVSPVVAC 166
Query: 184 GPAGAQFLGPVIVEIPH 200
GP GA FL P + H
Sbjct: 167 GPHGASFLKPCTLTFKH 183
>gi|4505229 Fas-associated via death domain [Homo sapiens]
Length = 208
Score = 37.4 bits (85), Expect = 0.071
Identities = 19/63 (30%), Positives = 31/63 (49%)
Query: 617 IVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALT 676
++ D++G W LAR+L S +I+ I P +L + L+ W + +NAT L
Sbjct: 103 VICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLV 162
Query: 677 SVL 679
L
Sbjct: 163 GAL 165
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 37.4 bits (85), Expect = 0.071
Identities = 59/263 (22%), Positives = 95/263 (36%), Gaps = 32/263 (12%)
Query: 739 PTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLE 798
P PF + I S+ + ++ S + + ++ V+ E E++++
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSE-------EKIKVVEKSEKETVIVEEQT--EETQVT 467
Query: 799 DSVPLTEMPEAVDVD----ESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRLDDSP 854
+ V E EA + + E E + ET S E A + + SP
Sbjct: 468 EEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSP 527
Query: 855 DQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGS 914
+ + K A + + EAK+ + + K S E P+ S
Sbjct: 528 AEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAK-SPAEVKSPEKAKS 586
Query: 915 GHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSS 974
EE SP A KS E+ + EE K SPA+ K + +EE S
Sbjct: 587 PAKEEAKSPAEA--KSPEKAKSPVKEEAK-------------SPAEAKSPV---KEEAKS 628
Query: 975 GSEQKQGEGFKVKTKKEIRHVEK 997
+E K E K TK+E + EK
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEK 651
>gi|6754638 microtubule-associated protein tau isoform 2 [Homo
sapiens]
Length = 441
Score = 37.0 bits (84), Expect = 0.093
Identities = 66/278 (23%), Positives = 108/278 (38%), Gaps = 30/278 (10%)
Query: 740 TPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAED--ASLEDS-- 795
T Q + +D ESPL+TP+ DG S+ ++D TAED A L D
Sbjct: 30 TMHQDQEGDTDAGLKESPLQTPTE--DG---SEEPGSETSDAKSTPTAEDVTAPLVDEGA 84
Query: 796 --KLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRLDDS 853
K + P TE+PE +E+ + + S ++E ++G++ + G DD
Sbjct: 85 PGKQAAAQPHTEIPEGTTAEEAGIGDTP-SLEDE-AAGHVTQARMVSKSKDGTGS--DDK 140
Query: 854 PDQCRDSITSYLK-------GEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKET 906
+ D T G+ G+ A + P KT E +
Sbjct: 141 KAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSP 200
Query: 907 LKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLS 966
P GS P+ P + E K+ + T P P S K +T+P +
Sbjct: 201 GSPGTPGS-RSRTPSLPTPPTR----EPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKN 255
Query: 967 LHEEEGSSGSEQKQGEGFKVK---TKKEIRHVEKKSHS 1001
+ + GS+ + + Q G KV+ K ++ +V+ K S
Sbjct: 256 VKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGS 293
>gi|4503337 dyskerin isoform 1 [Homo sapiens]
Length = 514
Score = 36.6 bits (83), Expect = 0.12
Identities = 32/127 (25%), Positives = 51/127 (40%), Gaps = 12/127 (9%)
Query: 870 GKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQK 929
G + +G T+ TP + Y D + + KE + + V E A ++
Sbjct: 396 GLLDKHGKPTDSTPATWKQEYV-----DYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRE 450
Query: 930 SLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTK 989
S E+ +ET P P +KK + S D K + L E G+ + K K K
Sbjct: 451 SESES-----DETPPAAPQLIKKEKKKSKKDKKAKAGL--ESGAEPGDGDSDTTKKKKKK 503
Query: 990 KEIRHVE 996
K+ + VE
Sbjct: 504 KKAKEVE 510
>gi|221139728 pleckstrin homology domain containing, family M (with
RUN domain) member 2 [Homo sapiens]
Length = 1019
Score = 36.6 bits (83), Expect = 0.12
Identities = 65/330 (19%), Positives = 118/330 (35%), Gaps = 46/330 (13%)
Query: 610 RTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKN 669
R I+ V H+ T L R + +N+ +E+ L ++ LL K+ ++
Sbjct: 74 REAIKQIEVLQHVA---TNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALV 130
Query: 670 ATTDALTSVLTKINRIDIVTL---LEGPIFDYG----NISGTRSFADENNVFHDPVDGYP 722
+ D LT LT ++ ++ + L+ P D + + D + V G
Sbjct: 131 CSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSD 190
Query: 723 SLQVEL---ETPTGLHY-----------------------TPPTPFQQDDYF-------- 748
SL + T T L + P T ++ D
Sbjct: 191 SLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRS 250
Query: 749 --SDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDSVPLTEM 806
SD++S ++ R+P++ + S+D PV T E L+ TE+
Sbjct: 251 TASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTEL 310
Query: 807 PEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLK 866
+ ++ S +E +S +C+Q + G D + SP RDS + L
Sbjct: 311 EVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSPDTMLA 370
Query: 867 GEAGKFEANGSHTEITPEAKTKSYFPESQN 896
+ E S TE + ++ PE ++
Sbjct: 371 SPQEEGEGPSSTTESSERSEPGLLIPEMKD 400
>gi|21361086 tumor necrosis factor receptor superfamily, member 10a
[Homo sapiens]
Length = 468
Score = 36.2 bits (82), Expect = 0.16
Identities = 20/77 (25%), Positives = 38/77 (49%), Gaps = 5/77 (6%)
Query: 625 SWTELARELNFSVDEINQIRV--ENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKI 682
SW +L R+L+ + +EI+ +R P + + +L KWV + G+NA+ L L ++
Sbjct: 379 SWDQLMRQLDLTKNEIDVVRAGTAGPGDAL---YAMLMKWVNKTGRNASIHTLLDALERM 435
Query: 683 NRIDIVTLLEGPIFDYG 699
++ + D G
Sbjct: 436 EERHAKEKIQDLLVDSG 452
>gi|78482627 ring finger protein 30 isoform 1 [Homo sapiens]
Length = 400
Score = 36.2 bits (82), Expect = 0.16
Identities = 50/221 (22%), Positives = 88/221 (39%), Gaps = 33/221 (14%)
Query: 778 SADGPPVVTAEDASLEDSKLEDSVP-LTEMPEAVDVDESQLENVCLS------WQNETSS 830
S+ PP++ +++ + DS+L D + L + V +Q+E VC + Q + +
Sbjct: 197 SSSDPPILASQNTKIIDSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLN 256
Query: 831 GNLES-CAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKS 889
ES CA G LL L ++ + ++ EA+ E ++
Sbjct: 257 QRFESLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQS---- 312
Query: 890 YFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVS 949
E Q + Q KE + K+ VE P Y+ + T ++
Sbjct: 313 -MEEPQMALYLQQAKELIN-KVGAMSKVELAGRPEPGYESMEQFTVRV----------EH 360
Query: 950 MKKMSRTSPADGKPRLSLHE-------EEGSSGSEQKQGEG 983
+ +M RT D +P S E EEGS+G E+++ +G
Sbjct: 361 VAEMLRT--IDFQPGASGEEEEVAPDGEEGSAGPEEERPDG 399
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 35.8 bits (81), Expect = 0.21
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 2/74 (2%)
Query: 129 GSMRGSRHHGMRIIIPPRKCT--APTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPA 186
G + S G+ IIIP I ++ + + + P +GE L S LV GP
Sbjct: 1564 GGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPH 1623
Query: 187 GAQFLGPVIVEIPH 200
G +FL PV + +PH
Sbjct: 1624 GLKFLKPVELRLPH 1637
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 35.8 bits (81), Expect = 0.21
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 2/74 (2%)
Query: 129 GSMRGSRHHGMRIIIPPRKCT--APTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPA 186
G + S G+ IIIP I ++ + + + P +GE L S LV GP
Sbjct: 1644 GGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPH 1703
Query: 187 GAQFLGPVIVEIPH 200
G +FL PV + +PH
Sbjct: 1704 GLKFLKPVELRLPH 1717
>gi|4505393 nerve growth factor receptor precursor [Homo sapiens]
Length = 427
Score = 35.4 bits (80), Expect = 0.27
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 8/85 (9%)
Query: 607 PCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRD 666
P +R ++ ++ G +W LA EL + + I+ E LL W T+D
Sbjct: 341 PAKREEVEK-LLNGSAGDTWRHLAGELGYQPEHIDSFTHE-----ACPVRALLASWATQD 394
Query: 667 GKNATTDALTSVLTKINRIDIVTLL 691
+AT DAL + L +I R D+V L
Sbjct: 395 --SATLDALLAALRRIQRADLVESL 417
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 35.0 bits (79), Expect = 0.35
Identities = 22/84 (26%), Positives = 42/84 (50%), Gaps = 11/84 (13%)
Query: 207 KERELIVLRSENGETWKEHQ-----------FDSKNEDLTELLNGMDEELDSPEELGKKR 255
KE EL +R+EN KE Q F S E+L ++++ D ++ S EEL +
Sbjct: 761 KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 256 ICRIITKDFPQYFAVVSRIKQESN 279
+ ++ K+ ++ S++++ N
Sbjct: 821 LLKVANKEKTVQLSITSKVQELQN 844
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 35.0 bits (79), Expect = 0.35
Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 10/115 (8%)
Query: 893 ESQNDVGKQSTKETLKPKIHGSGH----VEEPAS----PLAAYQKSLEETSKLIIEETKP 944
E + KQ ++T K G G +EE ++ P AA K + + K++ E K
Sbjct: 513 EKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVL--EKKV 570
Query: 945 CVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKS 999
+ KK SR + K + E+ + + E K+ + KE++HV KS
Sbjct: 571 ALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKS 625
>gi|62241003 cardiomyopathy associated 5 [Homo sapiens]
Length = 4069
Score = 34.7 bits (78), Expect = 0.46
Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 857 CRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVG--KQSTKETLKPKIHGS 914
CRD I ++ + G S ++ ++ K F ES+ G TKET+K
Sbjct: 2642 CRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEK 2701
Query: 915 GHVEEPASPLAAYQKSLEETSKLIIEETKPCVPV 948
+P + LEE SK+++E+TK +PV
Sbjct: 2702 AVGTQP--------RPLEE-SKVLVEKTKTFLPV 2726
Score = 32.0 bits (71), Expect = 3.0
Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 8/71 (11%)
Query: 881 ITPEAKTKSYF-PESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLII 939
+ + KT++Y PES++ + T E K + E +S +AA +L S ++
Sbjct: 1109 LAQKQKTQAYLEPESEDLIPSHLTSEVEKGE-------REASSSVAAIPAALPAQSSIVK 1161
Query: 940 EETKPCVPVSM 950
EETKP P S+
Sbjct: 1162 EETKPASPHSV 1172
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,597,865
Number of Sequences: 37866
Number of extensions: 2069792
Number of successful extensions: 4645
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 4513
Number of HSP's gapped (non-prelim): 145
length of query: 1001
length of database: 18,247,518
effective HSP length: 112
effective length of query: 889
effective length of database: 14,006,526
effective search space: 12451801614
effective search space used: 12451801614
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.