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Search of human proteins with 12408638
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
sapiens]
(555 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s... 1122 0.0
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s... 1104 0.0
gi|194018524 solute carrier family 6, member 18 [Homo sapiens] 533 e-151
gi|51468073 solute carrier family 6, member 19 [Homo sapiens] 527 e-149
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s... 477 e-134
gi|58219014 solute carrier family 6, member 17 [Homo sapiens] 450 e-126
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ... 407 e-113
gi|55749589 solute carrier family 6, member 16 [Homo sapiens] 324 1e-88
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi... 315 5e-86
gi|4507043 solute carrier family 6 member 4 [Homo sapiens] 308 1e-83
gi|188528618 solute carrier family 6 (neurotransmitter transport... 308 1e-83
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap... 302 5e-82
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap... 302 5e-82
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap... 302 5e-82
gi|92859670 solute carrier family 6 (neurotransmitter transporte... 302 6e-82
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa... 294 2e-79
gi|171184408 solute carrier family 6 (neurotransmitter transport... 294 2e-79
gi|171184406 solute carrier family 6 (neurotransmitter transport... 294 2e-79
gi|171184404 solute carrier family 6 (neurotransmitter transport... 294 2e-79
gi|7657587 solute carrier family 6 (neurotransmitter transporter... 290 2e-78
gi|4557046 solute carrier family 6 member 2 [Homo sapiens] 287 2e-77
gi|197276623 solute carrier family 6 (neurotransmitter transport... 285 1e-76
gi|54607094 solute carrier family 6 (neurotransmitter transporte... 285 1e-76
gi|134304856 solute carrier family 6, member 7 [Homo sapiens] 282 5e-76
gi|21361581 solute carrier family 6 (neurotransmitter transporte... 281 1e-75
gi|6005715 solute carrier family 6 (amino acid transporter), mem... 274 2e-73
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s... 248 8e-66
gi|4507041 solute carrier family 6 (neurotransmitter transporter... 237 2e-62
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa... 231 2e-60
gi|197276625 solute carrier family 6 (neurotransmitter transport... 140 4e-33
>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
sapiens]
Length = 555
Score = 1122 bits (2903), Expect = 0.0
Identities = 555/555 (100%), Positives = 555/555 (100%)
Query: 1 MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY
Sbjct: 1 MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
Query: 61 LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP
Sbjct: 61 LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
Query: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180
LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV
Sbjct: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180
Query: 181 VYLCILRGTESTGKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAI 240
VYLCILRGTESTGKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAI
Sbjct: 181 VYLCILRGTESTGKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAI 240
Query: 241 IVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVK 300
IVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVK
Sbjct: 241 IVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVK 300
Query: 301 GYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFF 360
GYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFF
Sbjct: 301 GYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFF 360
Query: 361 MLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWF 420
MLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWF
Sbjct: 361 MLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWF 420
Query: 421 DIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLI 480
DIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLI
Sbjct: 421 DIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLI 480
Query: 481 VSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGT 540
VSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGT
Sbjct: 481 VSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGT 540
Query: 541 FVQRRLKRGDADPVA 555
FVQRRLKRGDADPVA
Sbjct: 541 FVQRRLKRGDADPVA 555
>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
sapiens]
Length = 592
Score = 1104 bits (2855), Expect = 0.0
Identities = 555/592 (93%), Positives = 555/592 (93%), Gaps = 37/592 (6%)
Query: 1 MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY
Sbjct: 1 MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
Query: 61 LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP
Sbjct: 61 LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
Query: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180
LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV
Sbjct: 121 LPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLV 180
Query: 181 VYLCILRGTESTGK-------------------------------------IEQLANPKA 203
VYLCILRGTESTGK IEQLANPKA
Sbjct: 181 VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKA 240
Query: 204 WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF 263
WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF
Sbjct: 241 WINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGF 300
Query: 264 KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL 323
KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL
Sbjct: 301 KATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSL 360
Query: 324 ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD 383
ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD
Sbjct: 361 ESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTD 420
Query: 384 SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV 443
SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV
Sbjct: 421 SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV 480
Query: 444 CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD 503
CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD
Sbjct: 481 CYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWD 540
Query: 504 ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA 555
ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
Sbjct: 541 ASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA 592
>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
Length = 628
Score = 533 bits (1373), Expect = e-151
Identities = 255/581 (43%), Positives = 373/581 (64%), Gaps = 44/581 (7%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
RP W N Q++ +C +AVGLGN+WRFPYLCQ YGGG+FL+PY+I L+ EG+P+ ++ELA
Sbjct: 18 RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQR+R+GS+G W ISPYLSGVG+ V +SF +S+YYN I AW WYL +SFQ PLPWS
Sbjct: 78 IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
Query: 125 VCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLC 184
CP + N TG+ EEC+ +S+ YFWYR+TLNI+ + ++G +QW +CL +W VVY+C
Sbjct: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197
Query: 185 ILRGTESTGKI-------------------------------------EQLANPKAWINA 207
++RG E+TGK+ L NP+ W++A
Sbjct: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257
Query: 208 ATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATF 267
ATQIFFSL L FG IAFASYN P N+CQK A++++L+N TS++ASI FS+ GFKAT
Sbjct: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317
Query: 268 NYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESEL 327
+YE+CL + L L N FD + ++ + V +L + +P + +++ +K C LE L
Sbjct: 318 DYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQL--PLKACLLEDFL 375
Query: 328 DTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKII 387
D + G GLAF+V+TE +M + +W++L+F ML LG+ +M G A++TPL D ++
Sbjct: 376 DKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVL 435
Query: 388 SSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVY 447
+PKEA++GLVCLV FT+++GNYW +IF+++AA+ +LL++ +E + V YVY
Sbjct: 436 PRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVY 495
Query: 448 GLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQG 507
G++RF D+ MTGR S YW++ W VSPLL+ ++FV Y+ + L+Y+AW+
Sbjct: 496 GMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL-TIFVAYII-LLFWKPLRYKAWNPKYE 553
Query: 508 QLVTKD---YPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545
++ YP +A A LL + +P+AAL + RR
Sbjct: 554 LFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594
>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
Length = 634
Score = 527 bits (1357), Expect = e-149
Identities = 246/585 (42%), Positives = 364/585 (62%), Gaps = 43/585 (7%)
Query: 4 ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63
+RP W N Q++ C+ + VGLGNVWRFPYLCQ +GGG+F++P++I+L++EG+PLLYLE
Sbjct: 31 SRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEF 90
Query: 64 AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123
A+GQR+R+GS+G W +I P L G+G+AS++ SF + +YYN I +W WYLF+SFQ+PLPW
Sbjct: 91 AIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPW 150
Query: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183
S CPLN N TGY +EC ++S YFWYR+TLNIS S+ ++G +QW LCL AW V+Y+
Sbjct: 151 SDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYM 210
Query: 184 CILRGTESTGK-------------------------------------IEQLANPKAWIN 206
C +RG E+TGK + +LA P W++
Sbjct: 211 CTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLD 270
Query: 207 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 266
A Q+FFS L FG LI+F+SYN NNC+K ++IVS+IN FTS++ +IV +S+ GF+AT
Sbjct: 271 AGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRAT 330
Query: 267 FNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESE 326
Y++C L L N FDL +G +T N ++ ++ P+ Y+++ Q C + +
Sbjct: 331 QRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQ--TCDINAF 388
Query: 327 LDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKI 386
L AV+GTGLAFIV+TEAI M +S LWSVL+F ML LG+ SM GN ++ PL D ++
Sbjct: 389 LSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRV 448
Query: 387 ISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYV 446
I PKE ++GL+CL IG +FT+ +G YW + + YA ++ LL+I E +V YV
Sbjct: 449 IPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYV 508
Query: 447 YGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQ 506
YG+ RF D++ M G + +W+V W VSPLL++ +F+F+ + + L Y WD
Sbjct: 509 YGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEV-SQELTYSIWDPGY 567
Query: 507 GQLVTK---DYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKR 548
+ YP + V+ ++ ++ IP A+ ++ ++
Sbjct: 568 EEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQK 612
>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
sapiens]
Length = 730
Score = 477 bits (1227), Expect = e-134
Identities = 251/601 (41%), Positives = 362/601 (60%), Gaps = 72/601 (11%)
Query: 1 MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
+E RP W + LQ++ A + ++VGLGNVWRFPYLCQ GGG++L+PY+I+L+V G+PL +
Sbjct: 57 VEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFF 116
Query: 61 LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
LEL+VGQR+R+GSIG W ISP L G+G AS VV +F+++YYNVI W+ +Y SFQ P
Sbjct: 117 LELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQP 176
Query: 121 LPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178
LPW CPL N +HT + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+ +CLL AW
Sbjct: 177 LPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAW 236
Query: 179 LVVYLCILRGTESTGKI-------------------------------------EQLANP 201
++V L +++G +S+GKI E + P
Sbjct: 237 VMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEP 296
Query: 202 KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIY 261
K W AATQ+FF+LGLGFG +IAF+SYN+ NNC A++VS IN FTS+ A++V F++
Sbjct: 297 KVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVL 356
Query: 262 GFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLASAYPSKYS- 312
GFKA E C+ + S + FL N+ Q + A Y Y
Sbjct: 357 GFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTAEDYHLVYDI 409
Query: 313 ------EMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLM 364
E FP + +C +E EL+ AVQGTGLAFI +TEA+ + S WSV++F ML+
Sbjct: 410 IQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVN 469
Query: 365 LGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFN 424
LG+GSM G I+TP+ D+ + KE ++ + CL+ IG++F +GNY+ +F+
Sbjct: 470 LGLGSMFGTIEGIVTPIVDTFKVR----KEILTVICCLLAFCIGLIFVQRSGNYFVTMFD 525
Query: 425 DYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLF 484
DY+ATL LL++V++E IAVC+VYG+ +F DLK M G A S Y+ MW +SPL+++SL
Sbjct: 526 DYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLL 585
Query: 485 VFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR 544
+ + + L+ Y AW + YP + L V LV + + +P+ F+ R
Sbjct: 586 IASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV----VFIVR 640
Query: 545 R 545
R
Sbjct: 641 R 641
>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
Length = 727
Score = 450 bits (1157), Expect = e-126
Identities = 234/582 (40%), Positives = 349/582 (59%), Gaps = 58/582 (9%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
RP W + LQ++ A I ++VGLGN+WRFPYLCQ GGG++LVPY+++LI+ G+PL +LELA
Sbjct: 60 RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
VGQR+R+GSIG W I P L G+G +S +V F+ +YYNVI W+ +Y F SFQ PLPWS
Sbjct: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179
Query: 125 VCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVY 182
CP+ NG+ + ECEK+S+T YFWYR+ L+IS S+ E+GG+ W+ LCLL+AW +V
Sbjct: 180 ECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVG 239
Query: 183 LCILRGTESTGKI-------------------------------------EQLANPKAWI 205
+ +++G +S+GK+ +++ +P+ W
Sbjct: 240 MAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299
Query: 206 NAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKA 265
AATQ+FF+LGLGFG +IAF+SYN+ NNC A +VS IN FTS+ A++V F++ GFKA
Sbjct: 300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKA 359
Query: 266 TFNYENCL-----KKVSLLLTNTFD-------LEDGFLTASNLEQVKGYLASAYPSKYSE 313
E C+ K + L TN + LT + ++ + + ++S
Sbjct: 360 NIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSA 419
Query: 314 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 373
+ + C LE ELD +VQGTGLAFI +TEA+ + S WSV++F ML+ LG+GSM+G
Sbjct: 420 L--GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477
Query: 374 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 433
A I TP+ D + +PKE + C+ +G++F +GNY+ +F+DY+ATL L
Sbjct: 478 MAGITTPIID----TFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLT 533
Query: 434 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 493
LIV++E IAV ++YG ++F +L M G ++ MW VSPL + L + +
Sbjct: 534 LIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593
Query: 494 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 535
T Y AW + +P +A+A++ L+ +T+ IP+
Sbjct: 594 TPP-GYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPV 634
>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
sapiens]
Length = 623
Score = 407 bits (1045), Expect = e-113
Identities = 222/550 (40%), Positives = 321/550 (58%), Gaps = 72/550 (13%)
Query: 52 IVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFW 111
+V G+PL +LEL+VGQR+R+GSIG W ISP L G+G AS VV +F+++YYNVI W+ +
Sbjct: 1 MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60
Query: 112 YLFHSFQDPLPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWE 169
Y SFQ PLPW CPL N +HT + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+
Sbjct: 61 YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120
Query: 170 PALCLLLAWLVVYLCILRGTESTGKI---------------------------------- 195
+CLL AW++V L +++G +S+GKI
Sbjct: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180
Query: 196 ---EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 252
E + PK W AATQ+FF+LGLGFG +IAF+SYN+ NNC A++VS IN FTS+
Sbjct: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240
Query: 253 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQ--------VKGYLA 304
A++V F++ GFKA E C+ + S + FL N+ Q + A
Sbjct: 241 ATLVVFAVLGFKANVINEKCITQNSETIMK-------FLKMGNISQDIIPHHINLSTVTA 293
Query: 305 SAYPSKYS-------EMFP--QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWS 355
Y Y E FP + +C +E EL+ AVQGTGLAFI +TEA+ + S WS
Sbjct: 294 EDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWS 353
Query: 356 VLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEA 415
V++F ML+ LG+GSM G I+TP+ D+ + KE ++ + CL+ IG++F +
Sbjct: 354 VMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVR----KEILTVICCLLAFCIGLIFVQRS 409
Query: 416 GNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGV 475
GNY+ +F+DY+ATL LL++V++E IAVC+VYG+ +F DLK M G A S Y+ MW +
Sbjct: 410 GNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 469
Query: 476 SPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 535
SPL+++SL + + + L+ Y AW + YP + L V LV + + +P+
Sbjct: 470 SPLMLLSLLIASVVNMGLSPP-GYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPV 528
Query: 536 AALGTFVQRR 545
F+ RR
Sbjct: 529 ----VFIVRR 534
>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
Length = 736
Score = 324 bits (830), Expect = 1e-88
Identities = 188/600 (31%), Positives = 303/600 (50%), Gaps = 50/600 (8%)
Query: 4 ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63
ARP W++ +++ A + +++ +WRF YL GG SF YI ML + G+PLL+LE+
Sbjct: 102 ARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEM 161
Query: 64 AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123
A GQ MRQG +G W+ I+P++ GVG +S +V F L +Y+NV+N+W +Y+ SFQ P+PW
Sbjct: 162 AAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPW 221
Query: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183
CPL N +G+D ECE+ + + YFWY++ L S +++ G + L L W +V
Sbjct: 222 EKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGA 281
Query: 184 CILRGTESTG-------------------------------------KIEQLANPKAWIN 206
++ G +STG KI + N W
Sbjct: 282 FMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSL 341
Query: 207 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 266
A Q+ + G+G GS+ + ASY SNNC A +VS+IN T + + F + GF AT
Sbjct: 342 AGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWAT 401
Query: 267 FNYENCLKK---VSLLLTNTFDLEDGFLTASNL----EQVKGYLASAYPSKYSEM-FPQI 318
C ++ + L L N L NL + S P M ++
Sbjct: 402 VITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREV 461
Query: 319 KNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAIL 378
C++E++ A +G AF+ + EA+ + S WS ++F MLL +G+ S +G I+
Sbjct: 462 TECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGII 521
Query: 379 TPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLV 438
TPL D+ K I G V L+ G+ FT +G+Y+ + +DY ++++V+
Sbjct: 522 TPLQDTFSFFRKHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVF 580
Query: 439 ETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLK 498
ET+AV + YG RRF +DL + G +S + +W + P++++ +FV + ++ +
Sbjct: 581 ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMV-HLCMKPIT 639
Query: 499 YQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR---RLKRGDADPVA 555
Y +WD+S + V + YP +AL ++ L A + IP + + R R K GD A
Sbjct: 640 YMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTA 699
>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
sapiens]
Length = 635
Score = 315 bits (808), Expect = 5e-86
Identities = 197/603 (32%), Positives = 281/603 (46%), Gaps = 132/603 (21%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W + F+ +C+ +AVGLGNVWRFPYLC GGG FL+PY+++ +V G+P+ +LE++
Sbjct: 52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ M+ GSI W I P G+G AS+V+ F+ + YY ++ AW F+YL SF LPW+
Sbjct: 112 LGQFMKAGSINVW-NICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
Query: 125 VCPLNGN-------------------HTGYDEECEKASSTQYFWYRKTLNISPSLQENGG 165
C N + D+ ++ S FW K L +S L+ G
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
Query: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------------ 195
+ WE LCLL W++VY C+ +G +STGKI
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
Query: 196 -------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 248
+L +P+ WI+A TQIFFS +G G+L A SYN +NNC K AII++LINS
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSG 350
Query: 249 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 308
TS FA V FSI GF A E G +
Sbjct: 351 TSFFAGFVVFSILGFMAA--------------------EQG----------------VHI 374
Query: 309 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 368
SK +E G GLAFI Y A+ M V+ LW+ L+FFMLL+LG+
Sbjct: 375 SKVAE------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 416
Query: 369 SMLGNTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDY 426
S +T L D S + +E L C + I + + G Y F +F+ Y
Sbjct: 417 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 476
Query: 427 AAT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFV 485
+A+ +LL E + V +VYG RF D+ M G + K W+ +PL+ + +F+
Sbjct: 477 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 536
Query: 486 F---YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 542
F Y + T Y W + G A+AL SS +C+PL LG +
Sbjct: 537 FNVVYYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLL 581
Query: 543 QRR 545
+ +
Sbjct: 582 RAK 584
>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
Length = 630
Score = 308 bits (788), Expect = 1e-83
Identities = 187/599 (31%), Positives = 283/599 (47%), Gaps = 123/599 (20%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W + F+ + I YAV LGNVWRFPY+C GGG+FL+PY IM I G+PL Y+ELA
Sbjct: 79 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ R G I WR I P G+G A +++F+++ YYN I AWA +YL SF D LPW+
Sbjct: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198
Query: 125 VCPLN---GNHTGYDEE------CEKASSTQYFWYRKTLNI--SPSLQENGGVQWEPALC 173
C + GN T Y E S + F+ R L I S LQ+ GG+ W+ ALC
Sbjct: 199 SCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALC 258
Query: 174 LLLAWLVVYLCILRGTESTGKI-------------------------------------E 196
++L + V+Y I +G +++GK+ +
Sbjct: 259 IMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQ 318
Query: 197 QLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIV 256
+L WI+AA QIFFSLG GFG L+AFASYN+ +NNC + A++ S++N TS + V
Sbjct: 319 KLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV 378
Query: 257 TFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFP 316
F++ G+ A E+ V A PS
Sbjct: 379 IFTVLGYMAEMRNED---------------------------VSEVAKDAGPS------- 404
Query: 317 QIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAA 376
L FI Y EAI NM S +++++F ML+ LG+ S
Sbjct: 405 -------------------LLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEG 445
Query: 377 ILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTME-AGNYWFDIFNDYAATLSLLLI 435
++T + D + + L ++ C G + T+ G Y + +YA ++L +
Sbjct: 446 VITAVLD-EFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTV 504
Query: 436 VLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTG 495
L+E +AV + YG+ +F D+K M G + W+W++ W +SPL ++ + +L
Sbjct: 505 ALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFL------- 557
Query: 496 TLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP-------LAALGTFVQRRLK 547
Q +L +YP +++ + + SS +CIP + GTF +R +K
Sbjct: 558 ------MSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIK 610
>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
GABA), member 1 [Homo sapiens]
Length = 599
Score = 308 bits (788), Expect = 1e-83
Identities = 180/552 (32%), Positives = 271/552 (49%), Gaps = 101/552 (18%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W F+ +C+ YA+GLGNVWRFPYLC GGG+FL+PY + LI G+PL LE +
Sbjct: 44 RDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECS 103
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ G +G W+ ++P GVG+A+ V+SF+L++YY VI +WA +YL++SF LPW
Sbjct: 104 LGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWK 162
Query: 125 VC--PLNGNH--TGYD--EECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178
C P N + + Y S+ FW R ++ L + G ++W A+ L +AW
Sbjct: 163 QCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAW 222
Query: 179 LVVYLCILRGTESTGKI-------------------------------------EQLANP 201
++VY CI +G TGK+ +L++
Sbjct: 223 ILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS 282
Query: 202 KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIY 261
+ W++AATQIFFS GLG GSLIA SYN NN + +IIV INS TS+FA V FSI
Sbjct: 283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIV 342
Query: 262 GFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNC 321
G++A +
Sbjct: 343 ---------------------------------------GFMA---------------HV 348
Query: 322 SLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPL 381
+ S D A G GLAF+ Y EA+ + +S LW++L+F MLLMLGI S +T L
Sbjct: 349 TKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITAL 408
Query: 382 TDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLLIVLVET 440
D +E VC+++ IG+ + G Y F +F+ Y+A+ +SLL +V E
Sbjct: 409 VDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFEC 468
Query: 441 IAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDY--ILTGTLK 498
+++ + YG+ RF +++ M G +WK+ W+ +P+++ +F+F + G
Sbjct: 469 VSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYV 528
Query: 499 YQAWDASQGQLV 510
+ W G L+
Sbjct: 529 FPKWGQGVGWLM 540
>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
sapiens]
Length = 633
Score = 302 bits (774), Expect = 5e-82
Identities = 191/610 (31%), Positives = 290/610 (47%), Gaps = 139/610 (22%)
Query: 8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
W N ++FV + YAVGLGNVWRFPYLC GGG+F+ PY IMLI G+PL ++EL+ GQ
Sbjct: 30 WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 89
Query: 68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
QG +G WR ISP GVG +VVS ++ +YYNV+ AF+Y F S LPW+ C
Sbjct: 90 FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 148
Query: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160
P N +H + ++ S ++ +W L +S +
Sbjct: 149 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 207
Query: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------- 195
G V+ CL ++WLVV+LC++RG +S+GK+
Sbjct: 208 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 267
Query: 196 ------------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 243
+++ K W +AA+QIF+SLG +G LI ASYN+ NNC + ++I+S
Sbjct: 268 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 327
Query: 244 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 303
+ N TS++A V FS + G++
Sbjct: 328 ITNCATSVYAGFVIFS---------------------------------------ILGFM 348
Query: 304 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 363
A+ S + A G GLAF+ Y EA+ + +S LWS+L+FFML+
Sbjct: 349 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 393
Query: 364 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 422
+LG+G+ ++T + D L K+ L V + +G+ T +AG YW +
Sbjct: 394 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 453
Query: 423 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 482
++YAA+ SL++I + +A+ Y+YG R + D++ M G ++++ W VSP +I
Sbjct: 454 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 513
Query: 483 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 542
+ VF + Y YQ YP +A+A+ L+ SS +CIPL A+
Sbjct: 514 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 556
Query: 543 QRRLKRGDAD 552
RL R D D
Sbjct: 557 -FRLCRTDGD 565
>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
sapiens]
Length = 706
Score = 302 bits (774), Expect = 5e-82
Identities = 191/610 (31%), Positives = 290/610 (47%), Gaps = 139/610 (22%)
Query: 8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
W N ++FV + YAVGLGNVWRFPYLC GGG+F+ PY IMLI G+PL ++EL+ GQ
Sbjct: 103 WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 162
Query: 68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
QG +G WR ISP GVG +VVS ++ +YYNV+ AF+Y F S LPW+ C
Sbjct: 163 FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 221
Query: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160
P N +H + ++ S ++ +W L +S +
Sbjct: 222 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 280
Query: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------- 195
G V+ CL ++WLVV+LC++RG +S+GK+
Sbjct: 281 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 340
Query: 196 ------------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 243
+++ K W +AA+QIF+SLG +G LI ASYN+ NNC + ++I+S
Sbjct: 341 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 400
Query: 244 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 303
+ N TS++A V FS + G++
Sbjct: 401 ITNCATSVYAGFVIFS---------------------------------------ILGFM 421
Query: 304 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 363
A+ S + A G GLAF+ Y EA+ + +S LWS+L+FFML+
Sbjct: 422 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 466
Query: 364 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 422
+LG+G+ ++T + D L K+ L V + +G+ T +AG YW +
Sbjct: 467 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 526
Query: 423 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 482
++YAA+ SL++I + +A+ Y+YG R + D++ M G ++++ W VSP +I
Sbjct: 527 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 586
Query: 483 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 542
+ VF + Y YQ YP +A+A+ L+ SS +CIPL A+
Sbjct: 587 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 629
Query: 543 QRRLKRGDAD 552
RL R D D
Sbjct: 630 -FRLCRTDGD 638
>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
sapiens]
Length = 652
Score = 302 bits (774), Expect = 5e-82
Identities = 191/610 (31%), Positives = 290/610 (47%), Gaps = 139/610 (22%)
Query: 8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
W N ++FV + YAVGLGNVWRFPYLC GGG+F+ PY IMLI G+PL ++EL+ GQ
Sbjct: 49 WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 108
Query: 68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
QG +G WR ISP GVG +VVS ++ +YYNV+ AF+Y F S LPW+ C
Sbjct: 109 FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 167
Query: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160
P N +H + ++ S ++ +W L +S +
Sbjct: 168 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 226
Query: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------- 195
G V+ CL ++WLVV+LC++RG +S+GK+
Sbjct: 227 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 286
Query: 196 ------------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 243
+++ K W +AA+QIF+SLG +G LI ASYN+ NNC + ++I+S
Sbjct: 287 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 346
Query: 244 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 303
+ N TS++A V FS + G++
Sbjct: 347 ITNCATSVYAGFVIFS---------------------------------------ILGFM 367
Query: 304 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 363
A+ S + A G GLAF+ Y EA+ + +S LWS+L+FFML+
Sbjct: 368 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 412
Query: 364 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 422
+LG+G+ ++T + D L K+ L V + +G+ T +AG YW +
Sbjct: 413 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 472
Query: 423 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 482
++YAA+ SL++I + +A+ Y+YG R + D++ M G ++++ W VSP +I
Sbjct: 473 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 532
Query: 483 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 542
+ VF + Y YQ YP +A+A+ L+ SS +CIPL A+
Sbjct: 533 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 575
Query: 543 QRRLKRGDAD 552
RL R D D
Sbjct: 576 -FRLCRTDGD 584
>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
glycine), member 5 [Homo sapiens]
Length = 797
Score = 302 bits (773), Expect = 6e-82
Identities = 187/591 (31%), Positives = 282/591 (47%), Gaps = 141/591 (23%)
Query: 3 KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
KAR W++ L F+ + + YAVGLGNVWRFPYL GGG+FL+PY++ML + G+P+ +LE
Sbjct: 189 KARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLE 248
Query: 63 LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
+++GQ QG + W+ I P L G G+A +++S +++YYNVI + +YLF SF LP
Sbjct: 249 VSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLP 307
Query: 123 WSVC--PLNG----------------------------------------NHTGYDEECE 140
W C P N N T +
Sbjct: 308 WGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTF 367
Query: 141 KASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKI----- 195
+ S +YF Y L IS ++ G ++W ALCL LAW++VY + +G +++GK+
Sbjct: 368 VSGSEEYFKY-FVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTA 426
Query: 196 --------------------------------EQLANPKAWINAATQIFFSLGLGFGSLI 223
E+L + W +AATQIFFSL +G LI
Sbjct: 427 TFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLI 486
Query: 224 AFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNT 283
+SYN+ NNC + +IV+ NS TSIFA V FS+ GF A +KV
Sbjct: 487 TLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN------ERKV------- 533
Query: 284 FDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTE 343
N+E V A QG G+AF+VY E
Sbjct: 534 -----------NIENV------------------------------ADQGPGIAFVVYPE 552
Query: 344 AIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDS--KIISSHLPKEAISGLVC 401
A+ + +S W++++F MLL LG+ +M I+T ++D K + +H P + +C
Sbjct: 553 ALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCIC 612
Query: 402 LVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTG 461
+G + G Y F + + YAA+ +L++I + E + + YVYGL+RF D++ M G
Sbjct: 613 FF--IMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIG 670
Query: 462 RAVSWYWKVMWAGVSP--LLIVSLFVFYLSDYILTGTLKYQAWDASQGQLV 510
+ +WKV WA V+P L + F FY + + G+ +Y W G L+
Sbjct: 671 FQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLM 721
>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
sapiens]
Length = 625
Score = 294 bits (752), Expect = 2e-79
Identities = 191/603 (31%), Positives = 271/603 (44%), Gaps = 142/603 (23%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W + F+ +C+ +AVGLGNVWRFPYLC GGG FL+PY+++ +V G+P+ +LE++
Sbjct: 52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ M+ GSI W I P G+G AS+V+ F+ + YY ++ AW F+YL SF LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
Query: 125 VCPLNGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGG 165
C N E+C AS FW K L +S L+ G
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230
Query: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------------ 195
+ WE LCLL W++VY C+ +G +STGKI
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290
Query: 196 -------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 248
+L +P+ WI+A TQIFFS +G G+L A SYN +NNC +
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NG 340
Query: 249 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 308
TS FA V FSI GF A E G +
Sbjct: 341 TSFFAGFVVFSILGFMAA--------------------EQG----------------VHI 364
Query: 309 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 368
SK +E G GLAFI Y A+ M V+ LW+ L+FFMLL+LG+
Sbjct: 365 SKVAE------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 406
Query: 369 SMLGNTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDY 426
S +T L D S + +E L C + I + + G Y F +F+ Y
Sbjct: 407 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 466
Query: 427 AAT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFV 485
+A+ +LL E + V +VYG RF D+ M G + K W+ +PL+ + +F+
Sbjct: 467 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 526
Query: 486 F---YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 542
F Y + T Y W + G A+AL SS +C+PL LG +
Sbjct: 527 FNVVYYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLL 571
Query: 543 QRR 545
+ +
Sbjct: 572 RAK 574
>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 [Homo sapiens]
Length = 614
Score = 294 bits (752), Expect = 2e-79
Identities = 189/595 (31%), Positives = 277/595 (46%), Gaps = 118/595 (19%)
Query: 3 KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
K R W N ++FV + +GLGNVWRFPYLC GGG+F +PY I V G+P+ +LE
Sbjct: 34 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLE 93
Query: 63 LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
+A+GQ QGS+ AWR I P G+G+ASVV+ +L++YY +I AWA +YLF SF LP
Sbjct: 94 VALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELP 153
Query: 123 WSVCP-----------LNGNHTGYDEECEKASS-TQYFWYRKTLNISPSLQENGGVQWEP 170
W+ C LN + G E +S FW R+ L I+ + + G ++WE
Sbjct: 154 WTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWEL 213
Query: 171 ALCLLLAWLVVYLCILRGTESTGKIE---------------------------------- 196
ALCLLLAW++ Y CI +G +STGK+
Sbjct: 214 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKP 273
Query: 197 ---QLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 253
+L +P+ W++A TQIFFS + G L A SYN+ NNC K I + +NS TS A
Sbjct: 274 DLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVA 333
Query: 254 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 313
V FSI GF + E G + E G A+P
Sbjct: 334 GFVVFSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAFP----- 368
Query: 314 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 373
+A+ M +SQLWS L+F ML+ LG+ S
Sbjct: 369 -----------------------------KAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399
Query: 374 TAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-L 430
++T D + + +E + + ++ IG+ E G Y F +F+ YA++ +
Sbjct: 400 VECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGI 459
Query: 431 SLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSD 490
LL + L E + + +VYG RF +++ M G K+ W ++P L ++ F+F LS
Sbjct: 460 CLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519
Query: 491 YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545
Y LKY YP + ++ L SS +C+PL + T ++ R
Sbjct: 520 YT---PLKYNN---------VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562
>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 [Homo sapiens]
Length = 614
Score = 294 bits (752), Expect = 2e-79
Identities = 189/595 (31%), Positives = 277/595 (46%), Gaps = 118/595 (19%)
Query: 3 KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
K R W N ++FV + +GLGNVWRFPYLC GGG+F +PY I V G+P+ +LE
Sbjct: 34 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLE 93
Query: 63 LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
+A+GQ QGS+ AWR I P G+G+ASVV+ +L++YY +I AWA +YLF SF LP
Sbjct: 94 VALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELP 153
Query: 123 WSVCP-----------LNGNHTGYDEECEKASS-TQYFWYRKTLNISPSLQENGGVQWEP 170
W+ C LN + G E +S FW R+ L I+ + + G ++WE
Sbjct: 154 WTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWEL 213
Query: 171 ALCLLLAWLVVYLCILRGTESTGKIE---------------------------------- 196
ALCLLLAW++ Y CI +G +STGK+
Sbjct: 214 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKP 273
Query: 197 ---QLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 253
+L +P+ W++A TQIFFS + G L A SYN+ NNC K I + +NS TS A
Sbjct: 274 DLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVA 333
Query: 254 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 313
V FSI GF + E G + E G A+P
Sbjct: 334 GFVVFSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAFP----- 368
Query: 314 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 373
+A+ M +SQLWS L+F ML+ LG+ S
Sbjct: 369 -----------------------------KAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399
Query: 374 TAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-L 430
++T D + + +E + + ++ IG+ E G Y F +F+ YA++ +
Sbjct: 400 VECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGI 459
Query: 431 SLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSD 490
LL + L E + + +VYG RF +++ M G K+ W ++P L ++ F+F LS
Sbjct: 460 CLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519
Query: 491 YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545
Y LKY YP + ++ L SS +C+PL + T ++ R
Sbjct: 520 YT---PLKYNN---------VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562
>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 [Homo sapiens]
Length = 614
Score = 294 bits (752), Expect = 2e-79
Identities = 189/595 (31%), Positives = 277/595 (46%), Gaps = 118/595 (19%)
Query: 3 KARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLE 62
K R W N ++FV + +GLGNVWRFPYLC GGG+F +PY I V G+P+ +LE
Sbjct: 34 KDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLE 93
Query: 63 LAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLP 122
+A+GQ QGS+ AWR I P G+G+ASVV+ +L++YY +I AWA +YLF SF LP
Sbjct: 94 VALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELP 153
Query: 123 WSVCP-----------LNGNHTGYDEECEKASS-TQYFWYRKTLNISPSLQENGGVQWEP 170
W+ C LN + G E +S FW R+ L I+ + + G ++WE
Sbjct: 154 WTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWEL 213
Query: 171 ALCLLLAWLVVYLCILRGTESTGKIE---------------------------------- 196
ALCLLLAW++ Y CI +G +STGK+
Sbjct: 214 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKP 273
Query: 197 ---QLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 253
+L +P+ W++A TQIFFS + G L A SYN+ NNC K I + +NS TS A
Sbjct: 274 DLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVA 333
Query: 254 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 313
V FSI GF + E G + E G A+P
Sbjct: 334 GFVVFSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAFP----- 368
Query: 314 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 373
+A+ M +SQLWS L+F ML+ LG+ S
Sbjct: 369 -----------------------------KAVTMMPLSQLWSCLFFIMLIFLGLDSQFVC 399
Query: 374 TAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-L 430
++T D + + +E + + ++ IG+ E G Y F +F+ YA++ +
Sbjct: 400 VECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGI 459
Query: 431 SLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSD 490
LL + L E + + +VYG RF +++ M G K+ W ++P L ++ F+F LS
Sbjct: 460 CLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519
Query: 491 YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545
Y LKY YP + ++ L SS +C+PL + T ++ R
Sbjct: 520 YT---PLKYNN---------VYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTR 562
>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
GABA), member 11 [Homo sapiens]
Length = 632
Score = 290 bits (743), Expect = 2e-78
Identities = 180/585 (30%), Positives = 271/585 (46%), Gaps = 127/585 (21%)
Query: 8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
W N ++FV + +GLGNVWRFPYLC GGG+FL+PY++ I G+P+ +LE A+GQ
Sbjct: 53 WNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQ 112
Query: 68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
+G I WR + P G+G A+ V+ L++YY +I AWA +YL + F LPW+ C
Sbjct: 113 FTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCG 172
Query: 127 ------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCL 174
LN ++ + S FW + L IS ++ G ++WE ALCL
Sbjct: 173 HEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCL 232
Query: 175 LLAWLVVYLCILRGTESTGKI-------------------------------------EQ 197
L AW + Y CI +GT+STGK+ +
Sbjct: 233 LAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSR 292
Query: 198 LANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVT 257
L++P+ W++A TQIFFS + G L A SYN +NNC + I++ +NS TS A
Sbjct: 293 LSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAI 352
Query: 258 FSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQ 317
FS+ GF A E G A E G
Sbjct: 353 FSVLGFMA--------------------YEQGVPIAEVAESGPG---------------- 376
Query: 318 IKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAI 377
LAFI Y +A+ M +S LW+ L+F ML+ LG+ S ++
Sbjct: 377 ------------------LAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESL 418
Query: 378 LTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLL 434
+T + D K+ +E + + +++ +G+V E G Y F +F+ YAA+ + LL
Sbjct: 419 VTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLF 478
Query: 435 IVLVETIAVCYVYGLRRFESDLKAMTG----RAVSWYWKVMWAGVSPLLIVSLFVFYLSD 490
+ + E I + +VYG RF +++ M G + W W +M +P + +F+F+L
Sbjct: 479 VAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIM----TPGICAGIFIFFLIK 534
Query: 491 YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 535
Y LKY + T YPA+ + L+ SS +CIPL
Sbjct: 535 Y---KPLKY-------NNIYT--YPAWGYGIGWLMALSSMLCIPL 567
>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
Length = 617
Score = 287 bits (734), Expect = 2e-77
Identities = 181/571 (31%), Positives = 274/571 (47%), Gaps = 124/571 (21%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W + F+ + + +AV L NVWRFPYLC GGG+FL+PY + LI+ GMPL Y+ELA
Sbjct: 56 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ R+G+ W+ I P+ GVG A ++++ ++ YYNVI AW+ +YLF SF LPW+
Sbjct: 116 LGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
Query: 125 VC-----------------PLNGNHTGYDEECEKASSTQYFWYRKTLNI--SPSLQENGG 165
C + GNHT Y + K + F+ R L++ S + + G
Sbjct: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSK--YKFTPAAEFYERGVLHLHESSGIHDIGL 232
Query: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------------ 195
QW+ LCL++ +V+Y + +G +++GK+
Sbjct: 233 PQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGIN 292
Query: 196 -------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 248
+L WI+AATQIFFSLG GFG LIAFASYN+ NNC + A++ S IN
Sbjct: 293 AYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCI 352
Query: 249 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 308
TS + FSI G+ A +E+ + N+E V
Sbjct: 353 TSFVSGFAIFSILGYMA---HEHKV---------------------NIEDV--------- 379
Query: 309 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 368
A +G GL FI+Y EAI + S W+V++F MLL LG+
Sbjct: 380 ---------------------ATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLD 418
Query: 369 SMLGNTAAILTPLTDS-KIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 427
S +G A++T L D +++ H ++ + V + + + G Y + + +A
Sbjct: 419 SSMGGMEAVITGLADDFQVLKRH--RKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFA 476
Query: 428 ATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSP-----LLIVS 482
A S+L VL+E I V + YG+ RF +D++ M G YW++ W VSP +++VS
Sbjct: 477 AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVS 536
Query: 483 LFVF---YLSDYILTGTLKYQAWDASQGQLV 510
+ F DYI + W + +V
Sbjct: 537 IINFKPLTYDDYIFPPWANWVGWGIALSSMV 567
>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
taurine), member 6 isoform a [Homo sapiens]
Length = 620
Score = 285 bits (728), Expect = 1e-76
Identities = 183/589 (31%), Positives = 262/589 (44%), Gaps = 128/589 (21%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W++ + FV + VGLGNVWRFPYLC GGG+FL+PY I L G+P+ +LE+
Sbjct: 41 REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ +G I W I P SG+G ASVV+ L++YY VI AWA +YLF SFQ LPW+
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160
Query: 125 VCPLNGNHTGYDEECEK------------ASSTQY------FWYRKTLNISPSLQENGGV 166
C NH+ C + SST + FW R L++SP + G +
Sbjct: 161 HC----NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSL 216
Query: 167 QWEPALCLLLAWLVVYLCILRGTESTGK-------------------------------- 194
+W+ ALCLLL WLV + CI +G STGK
Sbjct: 217 KWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKF 276
Query: 195 -----IEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFT 249
I +L +P+ WI+A TQIFFS + G++ + SYN+ N + +++ +NS T
Sbjct: 277 YLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGT 336
Query: 250 SIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPS 309
S + FSI GF A E G A E G AYP
Sbjct: 337 SFVSGFAIFSILGFMAQ--------------------EQGVDIADVAESGPGLAFIAYP- 375
Query: 310 KYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGS 369
+A+ M + WS+L+F MLL+LG+ S
Sbjct: 376 ---------------------------------KAVTMMPLPTFWSILFFIMLLLLGLDS 402
Query: 370 MLGNTAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 427
+T L D + +E VC ++ +G+ E G Y F +F+ YA
Sbjct: 403 QFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYA 462
Query: 428 AT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF 486
A+ + LL + E + ++YG ++ M G + K WA ++P+L V F+F
Sbjct: 463 ASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIF 522
Query: 487 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 535
L Y+ L Y T YP +A+ + L SS +C+PL
Sbjct: 523 SLVKYV---PLTYNK---------TYVYPNWAIGLGWSLALSSMLCVPL 559
>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
taurine), member 6 isoform a [Homo sapiens]
Length = 620
Score = 285 bits (728), Expect = 1e-76
Identities = 183/589 (31%), Positives = 262/589 (44%), Gaps = 128/589 (21%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W++ + FV + VGLGNVWRFPYLC GGG+FL+PY I L G+P+ +LE+
Sbjct: 41 REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ +G I W I P SG+G ASVV+ L++YY VI AWA +YLF SFQ LPW+
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160
Query: 125 VCPLNGNHTGYDEECEK------------ASSTQY------FWYRKTLNISPSLQENGGV 166
C NH+ C + SST + FW R L++SP + G +
Sbjct: 161 HC----NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSL 216
Query: 167 QWEPALCLLLAWLVVYLCILRGTESTGK-------------------------------- 194
+W+ ALCLLL WLV + CI +G STGK
Sbjct: 217 KWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKF 276
Query: 195 -----IEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFT 249
I +L +P+ WI+A TQIFFS + G++ + SYN+ N + +++ +NS T
Sbjct: 277 YLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGT 336
Query: 250 SIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPS 309
S + FSI GF A E G A E G AYP
Sbjct: 337 SFVSGFAIFSILGFMAQ--------------------EQGVDIADVAESGPGLAFIAYP- 375
Query: 310 KYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGS 369
+A+ M + WS+L+F MLL+LG+ S
Sbjct: 376 ---------------------------------KAVTMMPLPTFWSILFFIMLLLLGLDS 402
Query: 370 MLGNTAAILTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 427
+T L D + +E VC ++ +G+ E G Y F +F+ YA
Sbjct: 403 QFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYA 462
Query: 428 AT-LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF 486
A+ + LL + E + ++YG ++ M G + K WA ++P+L V F+F
Sbjct: 463 ASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIF 522
Query: 487 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 535
L Y+ L Y T YP +A+ + L SS +C+PL
Sbjct: 523 SLVKYV---PLTYNK---------TYVYPNWAIGLGWSLALSSMLCVPL 559
>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
Length = 636
Score = 282 bits (722), Expect = 5e-76
Identities = 176/559 (31%), Positives = 262/559 (46%), Gaps = 112/559 (20%)
Query: 8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
W L F+ +CI Y VGLGNVWRFPY GGG+FLVPY +ML + G+PL +LEL++GQ
Sbjct: 40 WTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQ 99
Query: 68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
G + W+ ISP G G A +++ +++YYN+I A+ +YLF S LPW C
Sbjct: 100 FSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCG 158
Query: 127 -------------PLNGNHT-GYDEECEKASSTQYFWYRKTLNI--SPSLQENGGVQWEP 170
+GN + C + S +Y W R L+I S + G ++W
Sbjct: 159 NWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHIQGSQGIGSPGEIRWNL 217
Query: 171 ALCLLLAWLVVYLCILRGTESTGKI----------------------------------- 195
LCLLLAW++V+LCIL+G +S+GK+
Sbjct: 218 CLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTP 277
Query: 196 --EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 253
L + K WI AA QIF+SLG+GFG L+ FASYN N + IV+L N+ TSI A
Sbjct: 278 QFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILA 337
Query: 254 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 313
FS+ G+ + L +A A P
Sbjct: 338 GFAIFSVLGY----------------------------MSQELGVPVDQVAKAGPGLAFV 369
Query: 314 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 373
++PQ A+ + +S WS L+FFMLL LG+ S
Sbjct: 370 VYPQ--------------------------AMTMLPLSPFWSFLFFFMLLTLGLDSQFAF 403
Query: 374 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 433
I+T +TD K SGL+C+ +G++ T + G YW + +DY+A+ L+
Sbjct: 404 LETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLM 463
Query: 434 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 493
++V+ +AV VYG++RF D+ M G Y++ W +SP +++L V+ + Y
Sbjct: 464 VVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQP 523
Query: 494 T--GTLKYQAWDASQGQLV 510
+ G+ ++ W G L+
Sbjct: 524 SEYGSYRFPPWAELLGILM 542
>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
GABA), member 13 [Homo sapiens]
Length = 602
Score = 281 bits (719), Expect = 1e-75
Identities = 185/590 (31%), Positives = 267/590 (45%), Gaps = 126/590 (21%)
Query: 8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
W N ++FV + +GLGNVWRFPYLC GGG+F +PY++ L G+P+ LE A+GQ
Sbjct: 35 WNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQ 94
Query: 68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126
QG + AWR I P G+G AS ++ L++YY ++ AWA +YLF SF LPW C
Sbjct: 95 YTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCY 154
Query: 127 ------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCL 174
NG+ G E S FW R+ L IS +Q G ++WE ALCL
Sbjct: 155 HEWNTEHCMEFQKTNGSLNGTSENA--TSPVIEFWERRVLKISDGIQHLGALRWELALCL 212
Query: 175 LLAWLVVYLCILRGTESTGKI-------------------------------------EQ 197
LLAW++ Y CI +G +STGK+ +
Sbjct: 213 LLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTR 272
Query: 198 LANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVT 257
L +P+ W++A TQIFFS + G L A SYN+ NNC + I + +NS TS A
Sbjct: 273 LWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAI 332
Query: 258 FSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQ 317
FSI GF + E G + E G AYP
Sbjct: 333 FSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAYP--------- 363
Query: 318 IKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAI 377
A+ + S LW+ +FFM+++LG+ S ++
Sbjct: 364 -------------------------RAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESL 398
Query: 378 LTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLL 434
+T L D + +E + V +V+ +G++ E G Y F +F+ YAA+ + LL
Sbjct: 399 VTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLF 458
Query: 435 IVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYI-L 493
+ + E++ V +VYG +RF +++ M G K W ++P + + F+F L Y L
Sbjct: 459 VAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPL 518
Query: 494 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP---LAALGT 540
T KY YP + A+ LL SS +CIP L LGT
Sbjct: 519 TYNKKY-------------TYPWWGDALGWLLALSSMVCIPAWSLYRLGT 555
>gi|6005715 solute carrier family 6 (amino acid transporter), member
14 [Homo sapiens]
Length = 642
Score = 274 bits (700), Expect = 2e-73
Identities = 173/583 (29%), Positives = 267/583 (45%), Gaps = 138/583 (23%)
Query: 8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67
W+ ++ + I YAVGLGNVWRFPYL GGG+FL+PY IML + G+PL +LE ++GQ
Sbjct: 39 WSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQ 98
Query: 68 RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW---- 123
G + WR I P GVG+ V++S F+++YYNVI A++ +Y+F SFQ LPW
Sbjct: 99 FASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCS 157
Query: 124 -------------SVCPLNGNHTGYDEECEKASS----------------------TQYF 148
+ C ++ + G E + S ++ +
Sbjct: 158 SWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQY 217
Query: 149 WYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKI------------- 195
W + L S + E G + W ALCLLLAWL+V + +G +S+GK+
Sbjct: 218 WNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLL 277
Query: 196 --------------------------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYN 229
+L + W +AATQIF+SL + +G L+A +SYN
Sbjct: 278 ILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYN 337
Query: 230 EPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDG 289
+ NNC AI+V L N TS+FA FSI G A + K+VS ++ + FDL
Sbjct: 338 KFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISG----KEVSQVVKSGFDL--- 390
Query: 290 FLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNME 349
AFI Y EA+ +
Sbjct: 391 -----------------------------------------------AFIAYPEALAQLP 403
Query: 350 VSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGM 409
WS+L+FFMLL LG+ S + I T + D + I+ CLV +G+
Sbjct: 404 GGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGL 463
Query: 410 VFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTG--RAVSW- 466
V +AG YW + + + A +L+ ++E + + ++YG RF D + M G R + W
Sbjct: 464 VCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWL 523
Query: 467 YWKVMWAGVSPLLIVSLFVFYLSDYILT--GTLKYQAWDASQG 507
+W+ W ++P+L++++F++ L + G + Y W + G
Sbjct: 524 WWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALG 566
>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
sapiens]
Length = 289
Score = 248 bits (634), Expect = 8e-66
Identities = 107/200 (53%), Positives = 152/200 (76%), Gaps = 2/200 (1%)
Query: 1 MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLY 60
+E RP W + LQ++ A + ++VGLGNVWRFPYLCQ GGG++L+PY+I+L+V G+PL +
Sbjct: 57 VEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFF 116
Query: 61 LELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDP 120
LEL+VGQR+R+GSIG W ISP L G+G AS VV +F+++YYNVI W+ +Y SFQ P
Sbjct: 117 LELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQP 176
Query: 121 LPWSVCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAW 178
LPW CPL N +HT + ECE++S+T Y+WYR+ LNIS S+ E+GG+ W+ +CLL AW
Sbjct: 177 LPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAW 236
Query: 179 LVVYLCILRGTESTGKIEQL 198
++V L +++G +S+GK+ L
Sbjct: 237 VMVCLAMIKGIQSSGKVSML 256
>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
dopamine), member 3 [Homo sapiens]
Length = 620
Score = 237 bits (604), Expect = 2e-62
Identities = 170/590 (28%), Positives = 274/590 (46%), Gaps = 125/590 (21%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W + F+ + I +AV L NVWRFPYLC GGG+FLVPY++ +++ GMPL Y+ELA
Sbjct: 60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELA 119
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ R+G+ G W+ I P L GVG +++S ++ +YNVI AWA YLF SF LPW
Sbjct: 120 LGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWI 178
Query: 125 VC---------------PLNGNHTGYDEECEKASSTQYFWYRKTLNI--SPSLQENGGVQ 167
C +G+ +G ++ + +YF R L++ S + + G +
Sbjct: 179 HCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYF-ERGVLHLHQSHGIDDLGPPR 237
Query: 168 WEPALCLLLAWLVVYLCILRGTESTGKI-------------------------------- 195
W+ CL+L +++Y + +G +++GK+
Sbjct: 238 WQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Query: 196 -----EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTS 250
+L WI+AATQ+ FSLG+GFG LIAF+SYN+ +NNC + AI+ + INS TS
Sbjct: 298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTS 357
Query: 251 IFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGY-LASAYPS 309
+ V FS G+ A +K S+ + + G + E + L+SA+
Sbjct: 358 FSSGFVVFSFLGYMA--------QKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAV 409
Query: 310 KYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGS 369
+ M + S +++ + G F + ++ E+ L+ VL F+L
Sbjct: 410 VFFIMLLTLGIDSAMGGMESVITGLIDEFQLLH---RHRELFTLFIVLATFLL------- 459
Query: 370 MLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT 429
L C+ N I VFT + + +AA
Sbjct: 460 ----------------------------SLFCVTNGGI-YVFT---------LLDHFAAG 481
Query: 430 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSP-----LLIVSLF 484
S+L VL+E I V + YG+ +F D++ MTG+ S YW++ W VSP +++VS+
Sbjct: 482 TSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIV 541
Query: 485 VFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP 534
F Y G + W + G ++ ++A++ + A +P
Sbjct: 542 TFRPPHY---GAYIFPDWANALGWVIATS----SMAMVPIYAAYKFCSLP 584
>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
sapiens]
Length = 520
Score = 231 bits (588), Expect = 2e-60
Identities = 165/539 (30%), Positives = 231/539 (42%), Gaps = 132/539 (24%)
Query: 69 MRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPL 128
M+ GSI W I P G+G AS+V+ F+ + YY ++ AW F+YL SF LPW+ C
Sbjct: 1 MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
Query: 129 NGNHTGY-----DEECEKASSTQY--------------FWYRKTLNISPSLQENGGVQWE 169
N E+C AS FW K L +S L+ G + WE
Sbjct: 60 TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119
Query: 170 PALCLLLAWLVVYLCILRGTESTGKI---------------------------------- 195
LCLL W++VY C+ +G +STGKI
Sbjct: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179
Query: 196 ---EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIF 252
+L +P+ WI+A TQIFFS +G G+L A SYN +NNC K AII++LINS TS F
Sbjct: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239
Query: 253 ASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYS 312
A V FSI G F+ A + SK +
Sbjct: 240 AGFVVFSILG---------------------------FMAAEQ---------GVHISKVA 263
Query: 313 EMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLG 372
E G GLAFI Y A+ M V+ LW+ L+FFMLL+LG+ S
Sbjct: 264 E------------------SGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV 305
Query: 373 NTAAILTPLTDSKIISSH--LPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT- 429
+T L D S + +E L C + I + + G Y F +F+ Y+A+
Sbjct: 306 GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG 365
Query: 430 LSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVF--- 486
+LL E + V +VYG RF D+ M G + K W+ +PL+ + +F+F
Sbjct: 366 TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV 425
Query: 487 YLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRR 545
Y + T Y W + G A+AL SS +C+PL LG ++ +
Sbjct: 426 YYEPLVYNNTYVYPWWGEAMGW-------AFAL--------SSMLCVPLHLLGCLLRAK 469
>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
taurine), member 6 isoform b [Homo sapiens]
Length = 200
Score = 140 bits (352), Expect = 4e-33
Identities = 67/157 (42%), Positives = 93/157 (59%)
Query: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
R W++ + FV + VGLGNVWRFPYLC GGG+FL+PY I L G+P+ +LE+
Sbjct: 41 REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100
Query: 65 VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124
+GQ +G I W I P SG+G ASVV+ L++YY VI AWA +YLF SFQ LPW+
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160
Query: 125 VCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQ 161
C + N E+ + + + + T SP ++
Sbjct: 161 HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIE 197
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,395,644
Number of Sequences: 37866
Number of extensions: 796654
Number of successful extensions: 2287
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2109
Number of HSP's gapped (non-prelim): 71
length of query: 555
length of database: 18,247,518
effective HSP length: 107
effective length of query: 448
effective length of database: 14,195,856
effective search space: 6359743488
effective search space used: 6359743488
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.