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Search of human proteins with 32479521
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32479521 dishevelled 1 [Homo sapiens]
(670 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32479521 dishevelled 1 [Homo sapiens] 1357 0.0
gi|41406097 dishevelled 3 [Homo sapiens] 860 0.0
gi|4758216 dishevelled 2 [Homo sapiens] 781 0.0
gi|39930479 DIX domain containing 1 isoform b [Homo sapiens] 72 1e-12
gi|83816971 DIX domain containing 1 isoform a [Homo sapiens] 72 1e-12
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 58 3e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 55 2e-07
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 55 2e-07
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 55 2e-07
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 54 4e-07
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 54 4e-07
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 54 4e-07
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 54 4e-07
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 54 4e-07
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 54 6e-07
gi|112382257 InaD-like [Homo sapiens] 54 6e-07
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 54 6e-07
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 54 6e-07
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 54 6e-07
gi|87196343 PDZ domain containing 2 [Homo sapiens] 54 6e-07
gi|148746189 multiple PDZ domain protein [Homo sapiens] 53 8e-07
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 53 8e-07
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 53 8e-07
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 53 1e-06
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 52 2e-06
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 52 2e-06
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 50 5e-06
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 50 5e-06
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 50 5e-06
gi|46559761 PDZ domain containing 4 [Homo sapiens] 50 5e-06
>gi|32479521 dishevelled 1 [Homo sapiens]
Length = 670
Score = 1357 bits (3511), Expect = 0.0
Identities = 670/670 (100%), Positives = 670/670 (100%)
Query: 1 MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVK 60
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVK
Sbjct: 1 MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVK 60
Query: 61 EEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSF 120
EEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSF
Sbjct: 61 EEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSF 120
Query: 121 HPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSAST 180
HPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSAST
Sbjct: 121 HPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSAST 180
Query: 181 ALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSI 240
ALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSI
Sbjct: 181 ALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSI 240
Query: 241 TDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDM 300
TDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDM
Sbjct: 241 TDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDM 300
Query: 301 LLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDP 360
LLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDP
Sbjct: 301 LLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDP 360
Query: 361 AAWLSHTAALTGALPRYELEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAV 420
AAWLSHTAALTGALPRYELEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAV
Sbjct: 361 AAWLSHTAALTGALPRYELEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAV 420
Query: 421 IGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLA 480
IGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLA
Sbjct: 421 IGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLA 480
Query: 481 TLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGST 540
TLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGST
Sbjct: 481 TLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGST 540
Query: 541 GSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLS 600
GSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLS
Sbjct: 541 GSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLS 600
Query: 601 RGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMG 660
RGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMG
Sbjct: 601 RGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMG 660
Query: 661 NPCEFFVDIM 670
NPCEFFVDIM
Sbjct: 661 NPCEFFVDIM 670
>gi|41406097 dishevelled 3 [Homo sapiens]
Length = 716
Score = 860 bits (2222), Expect = 0.0
Identities = 459/722 (63%), Positives = 545/722 (75%), Gaps = 58/722 (8%)
Query: 1 MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVK 60
M ETKIIYH+D +ETPYLVKLP+ ERVTLADFK VL RP +YKFFFKSMD DFGVVK
Sbjct: 1 MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQ-RP--SYKFFFKSMDDDFGVVK 57
Query: 61 EEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSF 120
EEI DDNAKLPCFNGRVVSWLV AEG+H D D+ ++LPPP+ERTGGIGDSRPPSF
Sbjct: 58 EEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSF 117
Query: 121 HPNVAS-SRDGMDNETGTESMVSHRRERARRRNR-EEAARTNGHPRGDRRRDVGLPPDSA 178
HP+ S++ +DN+T T+S+VS +RER RRR+ E A R NG +G+RRR+ G DS+
Sbjct: 118 HPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPG-GYDSS 176
Query: 179 STALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFS 238
ST +SSELE++SF DSDED STSR SSSTEQS++SRL+R+HKRRRRKQ++ + +R+SSFS
Sbjct: 177 STLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFS 236
Query: 239 SITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPG 298
SITDSTMSLNI+TVTLNME+++FLGISIVGQSN+RGDGGIYIGSIMKGGAVAADGRIEPG
Sbjct: 237 SITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPG 296
Query: 299 DMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPI 358
DMLLQVN++NFENMSNDDAVRVLREIV + GPI+LTVAKCWDP+PR FT+PR++P+RPI
Sbjct: 297 DMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPI 356
Query: 359 DPAAWLSHTAALTGALPRY------------------------ELEEAPLTVKSDMSAVV 394
DPAAW+SHTAA+TG P Y L++ L++ SDM+A+V
Sbjct: 357 DPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIV 416
Query: 395 RVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGF 454
+ M P+SGLE+RDRMWLKITI NA IG+DVVDWLY +VEGF +RREARKYAS+LLK GF
Sbjct: 417 KAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGF 476
Query: 455 LRHTVNKITFSEQCYYVFGDLCSNLATLNL--NSGSSGTSDQDTLAPLPHP-AAPWPLGQ 511
+RHTVNKITFSEQCYY+FGDLC N+A L+L + GSSG SDQDTLAPLPHP AAPWP+
Sbjct: 477 IRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPM-- 534
Query: 512 GYPYQYPGPP-PCFP-PAYQDPGFSYGSGSTGSQQSEGSKSSGSTRS-SRRAPGREKERR 568
+PYQYP PP P P P + + G+SYG GS SQ SEGS+SSGS RS S R ++ +
Sbjct: 535 AFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAG 594
Query: 569 AAGAGGSGSESDHTAPSGV------GSSWRERPAGQLSRGSSPRSQASAT---------- 612
+ +GGSGSESDHT S + S R PA S S AS+
Sbjct: 595 DSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYG 654
Query: 613 APGLP----PPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVD 668
PG+P PP GPPG PP R+LA+VPPELT SRQSF+ AMGNP EFFVD
Sbjct: 655 PPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVD 714
Query: 669 IM 670
+M
Sbjct: 715 VM 716
>gi|4758216 dishevelled 2 [Homo sapiens]
Length = 736
Score = 781 bits (2017), Expect = 0.0
Identities = 431/737 (58%), Positives = 508/737 (68%), Gaps = 78/737 (10%)
Query: 1 MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVK 60
+ ETK+IYH+DEEETPYLVK+PV ER+TL DFK+VL RP A K+FFKSMDQDFGVVK
Sbjct: 11 VGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQ-RPAGA-KYFFKSMDQDFGVVK 68
Query: 61 EEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPL--------ERTGGI 112
EEI DDNA+LPCFNGRVVSWLV ++ + + +L PP ERT GI
Sbjct: 69 EEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGI 128
Query: 113 GDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVG 172
GDSRPPSFHPNV+SS + ++ ET TES+VS RRER RRR+ E G R +
Sbjct: 129 GDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERH 188
Query: 173 LPP-DSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQA 231
L +S+ST ++SELES+S DSDE+ + SR SSSTEQS++SRL+++H RRRRKQR +
Sbjct: 189 LAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRH-RRRRKQRPPRL 247
Query: 232 DRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAA 291
+R SSFSS+TDSTMSLNI+TVTLNME+++FLGISIVGQSN+RGDGGIYIGSIMKGGAVAA
Sbjct: 248 ERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAA 307
Query: 292 DGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPR 351
DGRIEPGDMLLQVND+NFENMSNDDAVRVLR+IV + GPI LTVAKCWDP+P++YFT+PR
Sbjct: 308 DGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPR 367
Query: 352 ADPVRPIDPAAWLSHTAALTGALPRYE-----------------LEEAPLTVKSDMSAVV 394
+P++PIDPAAW+SH+AALTG P Y E L+V +DM++V
Sbjct: 368 NEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVT 427
Query: 395 RVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGF 454
+ M P+SGLE+RDRMWLKITI NA +G+DVVDWLY HVEGF ERREARKYAS LLK G
Sbjct: 428 KAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGL 487
Query: 455 LRHTVNKITFSEQCYYVFGDLCSNL------ATLNLNSGSSGTSDQDTLAPLPHPAAPWP 508
+RHTVNKITFSEQCYYVFGDL +LN N GSSG SDQDTLAPLP A PWP
Sbjct: 488 IRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLP-GATPWP 546
Query: 509 LGQGYPYQYPGPPPCF---PPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRA--PGR 563
L + YQYP P P PP ++ ++YG GS SQ SEGS+SSGSTRS A GR
Sbjct: 547 LLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGR 606
Query: 564 EKERRAAGAGGSGSESDHTAPSGVGSSWRE--RPAGQLSRGSSPRSQASATAPGL----- 616
+ER GSGSES+ PS G S R +G G P ++ AP L
Sbjct: 607 PEERAPESKSGSGSESE---PSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPG 663
Query: 617 -----------------------PPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQ 653
PPP P A PPG PPVR+L +VPPELT SRQ
Sbjct: 664 LHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQ----PPGAPPVRDLGSVPPELTASRQ 719
Query: 654 SFQKAMGNPCEFFVDIM 670
SF AMGNP EFFVD+M
Sbjct: 720 SFHMAMGNPSEFFVDVM 736
>gi|39930479 DIX domain containing 1 isoform b [Homo sapiens]
Length = 472
Score = 72.4 bits (176), Expect = 1e-12
Identities = 33/78 (42%), Positives = 49/78 (62%), Gaps = 2/78 (2%)
Query: 4 TKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEI 63
TK++Y D TP++V +P E VTL DFK + H Y F K++D +FG VKEEI
Sbjct: 390 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHF--KALDPEFGTVKEEI 447
Query: 64 FDDNAKLPCFNGRVVSWL 81
F D+ +P + G++V+W+
Sbjct: 448 FHDDDAIPGWEGKIVAWV 465
>gi|83816971 DIX domain containing 1 isoform a [Homo sapiens]
Length = 683
Score = 72.4 bits (176), Expect = 1e-12
Identities = 33/78 (42%), Positives = 49/78 (62%), Gaps = 2/78 (2%)
Query: 4 TKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEI 63
TK++Y D TP++V +P E VTL DFK + H Y F K++D +FG VKEEI
Sbjct: 601 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHF--KALDPEFGTVKEEI 658
Query: 64 FDDNAKLPCFNGRVVSWL 81
F D+ +P + G++V+W+
Sbjct: 659 FHDDDAIPGWEGKIVAWV 676
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 174 PPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADR 233
PP + + + S D++ ++L++S ++ +R + K + +
Sbjct: 992 PPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQ 1051
Query: 234 ASSFSSITD-----STMSLNIVTVTLNMERHHFLGISIVG-QSNDRGDGGIYIGSIMKGG 287
A + S+ I V L + + LG I+G + R D GI+I S+ GG
Sbjct: 1052 AYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGG 1111
Query: 288 AVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
DG ++PGD L+ VN V+ E +S+ A+ +L+
Sbjct: 1112 PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQ 1146
Score = 54.3 bits (129), Expect = 4e-07
Identities = 48/168 (28%), Positives = 79/168 (47%), Gaps = 27/168 (16%)
Query: 184 SELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDS 243
S+++ +++ S +D T + SS+ +TS+++ K +FSS
Sbjct: 1302 SDMDEATY-SSSQDHQTPKQESSSSVNTSNKMNFK-----------------TFSSSPPK 1343
Query: 244 TMSLNIVTVTLNMERHHFLGISIVGQSNDR-GDGGIYIGSIMKGGAVAADGRIEPGDMLL 302
+ V + N + LGIS+ G N GGIY+ +++ GA +DGRI GD +L
Sbjct: 1344 PGDIFEVELAKN---DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 1400
Query: 303 QVNDVNFENMSNDDAVRVLREIVSQTGP-ISLTVAKCWDPTPRSYFTV 349
VN V+ E ++ AV LR TG + L + K PT + + V
Sbjct: 1401 AVNGVSLEGATHKQAVETLR----NTGQVVHLLLEKGQSPTSKEHVPV 1444
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/46 (43%), Positives = 33/46 (71%), Gaps = 1/46 (2%)
Query: 277 GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
G Y+ +++ A +DGR++PGD L++VND + NM++ DAV +LR
Sbjct: 1792 GCYVHDVIQDPA-KSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1836
Score = 32.0 bits (71), Expect = 1.9
Identities = 12/45 (26%), Positives = 25/45 (55%)
Query: 278 IYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
+ + + G A G+I+ GD++L+VN + + +S + + LR
Sbjct: 1512 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/101 (36%), Positives = 55/101 (54%), Gaps = 14/101 (13%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI VG + GD IY+ I+ GGA DGR++ GD LL VN+ + E +++++AV
Sbjct: 152 LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAV 211
Query: 319 RVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPID 359
+L+ + + + L V K PT T+ DP P D
Sbjct: 212 AILK---NTSEVVYLKVGK---PT-----TIYMTDPYGPPD 241
Score = 52.8 bits (125), Expect = 1e-06
Identities = 33/100 (33%), Positives = 55/100 (55%), Gaps = 4/100 (4%)
Query: 228 LRQADRASSFSSITDSTMSLNIVTVTLNMERHHF-LGISIVGQSNDR---GDGGIYIGSI 283
L+Q ++A + I + + + +ER + LG SI G +++ D GI+I I
Sbjct: 22 LKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKI 81
Query: 284 MKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLRE 323
+ GGA A DGR+ D +L+VN+V+ +S+ AV L+E
Sbjct: 82 IPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKE 121
Score = 39.3 bits (90), Expect = 0.012
Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I++ I+ GG G ++ GD +L VN ++ S++ A L
Sbjct: 328 LGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 384
Query: 322 R 322
+
Sbjct: 385 K 385
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/101 (36%), Positives = 55/101 (54%), Gaps = 14/101 (13%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI VG + GD IY+ I+ GGA DGR++ GD LL VN+ + E +++++AV
Sbjct: 308 LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAV 367
Query: 319 RVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPID 359
+L+ + + + L V K PT T+ DP P D
Sbjct: 368 AILK---NTSEVVYLKVGK---PT-----TIYMTDPYGPPD 397
Score = 50.4 bits (119), Expect = 5e-06
Identities = 27/65 (41%), Positives = 40/65 (61%), Gaps = 3/65 (4%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI G +++ D GI+I I+ GGA A DGR+ D +L+VN+V+ +S+ AV
Sbjct: 213 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 272
Query: 319 RVLRE 323
L+E
Sbjct: 273 EALKE 277
Score = 39.3 bits (90), Expect = 0.012
Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I++ I+ GG G ++ GD +L VN ++ S++ A L
Sbjct: 536 LGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 592
Query: 322 R 322
+
Sbjct: 593 K 593
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/101 (36%), Positives = 55/101 (54%), Gaps = 14/101 (13%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI VG + GD IY+ I+ GGA DGR++ GD LL VN+ + E +++++AV
Sbjct: 203 LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAV 262
Query: 319 RVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPID 359
+L+ + + + L V K PT T+ DP P D
Sbjct: 263 AILK---NTSEVVYLKVGK---PT-----TIYMTDPYGPPD 292
Score = 50.4 bits (119), Expect = 5e-06
Identities = 27/65 (41%), Positives = 40/65 (61%), Gaps = 3/65 (4%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI G +++ D GI+I I+ GGA A DGR+ D +L+VN+V+ +S+ AV
Sbjct: 108 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 167
Query: 319 RVLRE 323
L+E
Sbjct: 168 EALKE 172
Score = 39.3 bits (90), Expect = 0.012
Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I++ I+ GG G ++ GD +L VN ++ S++ A L
Sbjct: 431 LGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 487
Query: 322 R 322
+
Sbjct: 488 K 488
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 54.3 bits (129), Expect = 4e-07
Identities = 28/64 (43%), Positives = 40/64 (62%), Gaps = 3/64 (4%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI VG + GD IY+ I++GGA DGR++ GD +L VN V E++ ++DAV
Sbjct: 213 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 272
Query: 319 RVLR 322
L+
Sbjct: 273 AALK 276
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/65 (38%), Positives = 38/65 (58%), Gaps = 3/65 (4%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI G +++ D I+I I+ GGA A DGR+ D +L VN+V+ +++ AV
Sbjct: 118 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 177
Query: 319 RVLRE 323
L+E
Sbjct: 178 EALKE 182
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/61 (36%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I+I I+ GG G + GD +L VN V+ N S++ A L
Sbjct: 366 LGFNIVGGEDGEG---IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIAL 422
Query: 322 R 322
+
Sbjct: 423 K 423
Score = 30.4 bits (67), Expect = 5.5
Identities = 33/113 (29%), Positives = 48/113 (42%), Gaps = 7/113 (6%)
Query: 166 DRRRDVGLPPDSASTALSSELESSSFVD-SDEDGSTSRLSSSTEQSTSSRLIRKHKR--R 222
D+ +D G + S L +D SDE+ +R S ++ I +R R
Sbjct: 483 DKTKDCGFLSQALSFRFGDVLH---VIDASDEEWWQARRVHSDSETDDIGFIPSKRRVER 539
Query: 223 RRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGD 275
R RL+ D SS S L+ TVT ME H+ I I+G + DR +
Sbjct: 540 REWSRLKAKDWGSSSGSQGREDSVLSYETVT-QMEVHYARPIIILGPTKDRAN 591
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 54.3 bits (129), Expect = 4e-07
Identities = 28/64 (43%), Positives = 40/64 (62%), Gaps = 3/64 (4%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI VG + GD IY+ I++GGA DGR++ GD +L VN V E++ ++DAV
Sbjct: 167 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 226
Query: 319 RVLR 322
L+
Sbjct: 227 AALK 230
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/65 (38%), Positives = 38/65 (58%), Gaps = 3/65 (4%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI G +++ D I+I I+ GGA A DGR+ D +L VN+V+ +++ AV
Sbjct: 72 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 131
Query: 319 RVLRE 323
L+E
Sbjct: 132 EALKE 136
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/61 (36%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I+I I+ GG G + GD +L VN V+ N S++ A L
Sbjct: 320 LGFNIVGGEDGEG---IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIAL 376
Query: 322 R 322
+
Sbjct: 377 K 377
Score = 30.4 bits (67), Expect = 5.5
Identities = 33/113 (29%), Positives = 48/113 (42%), Gaps = 7/113 (6%)
Query: 166 DRRRDVGLPPDSASTALSSELESSSFVD-SDEDGSTSRLSSSTEQSTSSRLIRKHKR--R 222
D+ +D G + S L +D SDE+ +R S ++ I +R R
Sbjct: 437 DKTKDCGFLSQALSFRFGDVLH---VIDASDEEWWQARRVHSDSETDDIGFIPSKRRVER 493
Query: 223 RRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGD 275
R RL+ D SS S L+ TVT ME H+ I I+G + DR +
Sbjct: 494 REWSRLKAKDWGSSSGSQGREDSVLSYETVT-QMEVHYARPIIILGPTKDRAN 545
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 54.3 bits (129), Expect = 4e-07
Identities = 48/168 (28%), Positives = 79/168 (47%), Gaps = 27/168 (16%)
Query: 184 SELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDS 243
S+++ +++ S +D T + SS+ +TS+++ K +FSS
Sbjct: 1130 SDMDEATY-SSSQDHQTPKQESSSSVNTSNKMNFK-----------------TFSSSPPK 1171
Query: 244 TMSLNIVTVTLNMERHHFLGISIVGQSNDR-GDGGIYIGSIMKGGAVAADGRIEPGDMLL 302
+ V + N + LGIS+ G N GGIY+ +++ GA +DGRI GD +L
Sbjct: 1172 PGDIFEVELAKN---DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 1228
Query: 303 QVNDVNFENMSNDDAVRVLREIVSQTGP-ISLTVAKCWDPTPRSYFTV 349
VN V+ E ++ AV LR TG + L + K PT + + V
Sbjct: 1229 AVNGVSLEGATHKQAVETLR----NTGQVVHLLLEKGQSPTSKEHVPV 1272
Score = 53.5 bits (127), Expect = 6e-07
Identities = 29/81 (35%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 243 STMSLNIVTVTLNMERHHFLGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDML 301
S+ I V L + + LG I+G + R D GI+I S+ GG DG ++PGD L
Sbjct: 894 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 953
Query: 302 LQVNDVNFENMSNDDAVRVLR 322
+ VN V+ E +S+ A+ +L+
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQ 974
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/46 (43%), Positives = 33/46 (71%), Gaps = 1/46 (2%)
Query: 277 GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
G Y+ +++ A +DGR++PGD L++VND + NM++ DAV +LR
Sbjct: 1620 GCYVHDVIQDPA-KSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1664
Score = 32.0 bits (71), Expect = 1.9
Identities = 12/45 (26%), Positives = 25/45 (55%)
Query: 278 IYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
+ + + G A G+I+ GD++L+VN + + +S + + LR
Sbjct: 1340 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 54.3 bits (129), Expect = 4e-07
Identities = 48/168 (28%), Positives = 79/168 (47%), Gaps = 27/168 (16%)
Query: 184 SELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDS 243
S+++ +++ S +D T + SS+ +TS+++ K +FSS
Sbjct: 1321 SDMDEATY-SSSQDHQTPKQESSSSVNTSNKMNFK-----------------TFSSSPPK 1362
Query: 244 TMSLNIVTVTLNMERHHFLGISIVGQSNDR-GDGGIYIGSIMKGGAVAADGRIEPGDMLL 302
+ V + N + LGIS+ G N GGIY+ +++ GA +DGRI GD +L
Sbjct: 1363 PGDIFEVELAKN---DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 1419
Query: 303 QVNDVNFENMSNDDAVRVLREIVSQTGP-ISLTVAKCWDPTPRSYFTV 349
VN V+ E ++ AV LR TG + L + K PT + + V
Sbjct: 1420 AVNGVSLEGATHKQAVETLR----NTGQVVHLLLEKGQSPTSKEHVPV 1463
Score = 53.5 bits (127), Expect = 6e-07
Identities = 29/81 (35%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 243 STMSLNIVTVTLNMERHHFLGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDML 301
S+ I V L + + LG I+G + R D GI+I S+ GG DG ++PGD L
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 302 LQVNDVNFENMSNDDAVRVLR 322
+ VN V+ E +S+ A+ +L+
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQ 1165
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/46 (43%), Positives = 33/46 (71%), Gaps = 1/46 (2%)
Query: 277 GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
G Y+ +++ A +DGR++PGD L++VND + NM++ DAV +LR
Sbjct: 1811 GCYVHDVIQDPA-KSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1855
Score = 32.0 bits (71), Expect = 1.9
Identities = 12/45 (26%), Positives = 25/45 (55%)
Query: 278 IYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
+ + + G A G+I+ GD++L+VN + + +S + + LR
Sbjct: 1531 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 54.3 bits (129), Expect = 4e-07
Identities = 25/72 (34%), Positives = 47/72 (65%), Gaps = 1/72 (1%)
Query: 252 VTLNMERHHFLGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFE 310
+T+ E H LG+++ G + + G+ I++ S+ G +A DGRI+ GD+LL +N ++
Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
Query: 311 NMSNDDAVRVLR 322
N+S+ +AV +L+
Sbjct: 529 NLSHSEAVAMLK 540
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/93 (35%), Positives = 51/93 (54%), Gaps = 5/93 (5%)
Query: 235 SSFSSITDSTMSL---NIVTVTLNMERHHF-LGISIVGQSNDRGDGGIYIGSIMKGGAVA 290
S+ + T +SL I T+ ++ + LGISIVG N+ I I + + G +A
Sbjct: 214 SAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVG-GNETPLINIVIQEVYRDGVIA 272
Query: 291 ADGRIEPGDMLLQVNDVNFENMSNDDAVRVLRE 323
DGR+ GD +LQVN+ N N+S++ A VL +
Sbjct: 273 RDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
Score = 40.0 bits (92), Expect = 0.007
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 5/78 (6%)
Query: 263 GISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
G SIVG + + +I +I+ G DGR++ GDM++ VN ++ MS+ V +L
Sbjct: 612 GFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML 671
Query: 322 REIVSQTGPISLTVAKCW 339
+E Q ++LTV CW
Sbjct: 672 KE---QRNKVTLTVI-CW 685
Score = 37.4 bits (85), Expect = 0.045
Identities = 21/82 (25%), Positives = 47/82 (57%), Gaps = 6/82 (7%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LGI +V ++++ G ++I +++GG A DGR+ D +L +N + + + + A +++
Sbjct: 351 LGIKLVRRTDEPG---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQII 407
Query: 322 REIVSQTGPISLTVAKCWDPTP 343
+ + ++LT+A+ P P
Sbjct: 408 Q---ASGERVNLTIARPGKPQP 426
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 53.5 bits (127), Expect = 6e-07
Identities = 31/79 (39%), Positives = 48/79 (60%), Gaps = 6/79 (7%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI +G + GD IYI I++GGA DGR++ GD LL VN+ N +++ +++AV
Sbjct: 236 LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAV 295
Query: 319 RVLREIVSQTGPISLTVAK 337
L+ + + + L VAK
Sbjct: 296 ASLK---NTSDMVYLKVAK 311
Score = 50.1 bits (118), Expect = 7e-06
Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI G ++ D GI+I I+ GGA A DGR+ D +L+VN+V+ + + AV
Sbjct: 141 LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV 200
Query: 319 RVLREIVSQTGPISLTVAKCWDPTPRSYFTV 349
L+E GP+ V + P P + V
Sbjct: 201 EALKE----AGPVVRLVVRRRQPPPETIMEV 227
Score = 41.6 bits (96), Expect = 0.002
Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I++ I+ GG G + GD +L VN VN N +++ A L
Sbjct: 396 LGFNIVGGEDGEG---IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 452
Query: 322 R 322
+
Sbjct: 453 K 453
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 53.5 bits (127), Expect = 6e-07
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 246 SLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVN 305
+L I V L + LG+SIVG+ N G++I I+KGGA DGR+ GD +L VN
Sbjct: 1528 NLEIFPVDLQKKAGRGLGLSIVGKRNG---SGVFISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 306 DVNFENMSNDDAVRVLR 322
+ N S + +L+
Sbjct: 1585 GEDMRNASQETVATILK 1601
Score = 53.1 bits (126), Expect = 8e-07
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 24/203 (11%)
Query: 262 LGISIVGQSNDRGDG---GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LGI IVG G GIY+ SI+ G A +G I+ D ++ V+ VN + +N D V
Sbjct: 376 LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVV 435
Query: 319 RVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPR-- 376
VLR Q ++L K T R V P+ P A LTGA+
Sbjct: 436 EVLRN-AGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALF-----LTGAVETET 489
Query: 377 ------YELEEAPLTVKSD-MSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWL 429
E++E T+K+D + A+ ++ ++PDS W ++G D +
Sbjct: 490 NVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRW------ENLLGPDYEVMV 543
Query: 430 YTHVEGFKERREARKYASSLLKH 452
T + E +KY+ L H
Sbjct: 544 ATLDTQIADDAELQKYSKLLPIH 566
Score = 49.7 bits (117), Expect = 9e-06
Identities = 45/175 (25%), Positives = 77/175 (44%), Gaps = 26/175 (14%)
Query: 174 PPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRR--------K 225
P S+S + + + + S+EDGS +S S +L ++++
Sbjct: 1334 PVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSS 1393
Query: 226 QRLRQADRASSFSSITDST--------MSLNIVTVTLNMERHHF---------LGISIVG 268
Q + A +S S+ D T +S++ T + + LG+SIVG
Sbjct: 1394 QEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVG 1453
Query: 269 QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLRE 323
D I I + + GA A DGR+ GD +L+VN V+ N S+++A+ LR+
Sbjct: 1454 -GKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQ 1507
Score = 43.5 bits (101), Expect = 6e-04
Identities = 35/141 (24%), Positives = 61/141 (43%), Gaps = 19/141 (13%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG+S+ G + DR I++ I G AADGR+ GD LL++N+ S+ +A ++
Sbjct: 1249 LGLSLAG-NKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAII 1307
Query: 322 REIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYELEE 381
+ S+ + + + + F VP + P D +
Sbjct: 1308 KTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSG------------------T 1349
Query: 382 APLTVKSDMSAVVRVMQLPDS 402
P++ + D S V + QLP+S
Sbjct: 1350 EPISSEEDGSVEVGIKQLPES 1370
Score = 43.1 bits (100), Expect = 8e-04
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 8/94 (8%)
Query: 233 RASSFSSITDSTMSLNI----VTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGA 288
++S+ SS+ D+T+ + V + LG IVG G+ + +I+ GG
Sbjct: 225 KSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTS----GVVVRTIVPGGL 280
Query: 289 VAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
DGR++ GD +L++ N + M+++ +VLR
Sbjct: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/58 (39%), Positives = 32/58 (55%)
Query: 267 VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREI 324
+G D DG YI SI+ GG V G ++P D LL+VN + S +AV L+E+
Sbjct: 570 LGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEV 627
Score = 37.0 bits (84), Expect = 0.059
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 11/90 (12%)
Query: 262 LGISIVGQS-------NDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSN 314
LGISIVG N GI+I +++ ++ GD +L+V+ V+ +N S+
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
Query: 315 DDAVRVLREIVSQTGPISLTVAKCWDPTPR 344
+AV E + G + + + TPR
Sbjct: 1139 SEAV----EAIKNAGNPVVFIVQSLSSTPR 1164
Score = 34.3 bits (77), Expect = 0.38
Identities = 21/65 (32%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 262 LGISIVGQSN--DRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVR 319
LG SI+ + D I I S++ G G + PGD L+ VN+ +N S +AV
Sbjct: 696 LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVE 755
Query: 320 VLREI 324
+L+ +
Sbjct: 756 ILKAV 760
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 53.5 bits (127), Expect = 6e-07
Identities = 29/81 (35%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 243 STMSLNIVTVTLNMERHHFLGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDML 301
S+ I V L + + LG I+G + R D GI+I S+ GG DG ++PGD L
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 302 LQVNDVNFENMSNDDAVRVLR 322
+ VN V+ E +S+ A+ +L+
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQ 1165
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/173 (27%), Positives = 79/173 (45%), Gaps = 32/173 (18%)
Query: 184 SELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDS 243
S+++ +++ S +D T + SS+ +TS+++ K +FSS
Sbjct: 1321 SDMDEATY-SSSQDHQTPKQESSSSVNTSNKMNFK-----------------TFSSSPPK 1362
Query: 244 TMSLNIVTVTLNMERHHFLGISIV------GQSNDRGDGGIYIGSIMKGGAVAADGRIEP 297
+ V + N + LGIS+ G + GGIY+ +++ GA +DGRI
Sbjct: 1363 PGDIFEVELAKN---DNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK 1419
Query: 298 GDMLLQVNDVNFENMSNDDAVRVLREIVSQTGP-ISLTVAKCWDPTPRSYFTV 349
GD +L VN V+ E ++ AV LR TG + L + K PT + + V
Sbjct: 1420 GDRVLAVNGVSLEGATHKQAVETLR----NTGQVVHLLLEKGQSPTSKEHVPV 1468
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/46 (43%), Positives = 33/46 (71%), Gaps = 1/46 (2%)
Query: 277 GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
G Y+ +++ A +DGR++PGD L++VND + NM++ DAV +LR
Sbjct: 1816 GCYVHDVIQDPA-KSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1860
Score = 32.0 bits (71), Expect = 1.9
Identities = 12/45 (26%), Positives = 25/45 (55%)
Query: 278 IYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
+ + + G A G+I+ GD++L+VN + + +S + + LR
Sbjct: 1536 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1580
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 53.5 bits (127), Expect = 6e-07
Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 242 DSTMSLNIVTVTLNMERHHFLGISIVGQSN--DRGDGGIYIGSIMKGGAVAADGRIEPGD 299
D T V LN LG+S+ G + + D GI++ SI+ GGA + DGR+ D
Sbjct: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVND 640
Query: 300 MLLQVNDVNFENMSNDDAVRVLREIVS----QTGPISLTVAK 337
L+ VN + +N DA+ LR +S + G I L VA+
Sbjct: 641 QLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVAR 682
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/75 (36%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Query: 262 LGISIVGQS-NDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV 320
LG SI + G IY+ +I+ GA DGR++ GD L++VN V+ S ++ V +
Sbjct: 471 LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSL 530
Query: 321 LREIVSQTGPISLTV 335
LR G +SL V
Sbjct: 531 LRS-TKMEGTVSLLV 544
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 53.5 bits (127), Expect = 6e-07
Identities = 29/75 (38%), Positives = 49/75 (65%), Gaps = 3/75 (4%)
Query: 262 LGISIVGQSND-RGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV 320
LG SIVG + G GIY+ +I GGA AADGR++ GD +L++N + +++ DA++
Sbjct: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
Query: 321 LREIVSQTGPISLTV 335
++ ++ G ++LTV
Sbjct: 287 FKQ--AKKGLLTLTV 299
Score = 42.4 bits (98), Expect = 0.001
Identities = 30/111 (27%), Positives = 54/111 (48%), Gaps = 8/111 (7%)
Query: 232 DRASSFSSITD----STMSLNIVTVTLNMERHHFLGISIVGQSND-RGDGGIYIGSIMKG 286
D A+S S+ +D ST + TVTL + LG S+ G GD + I I KG
Sbjct: 1211 DSAASASAASDVSVESTAEATVCTVTLE-KMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269
Query: 287 GAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAK 337
A ++PGD +LQ+ + ++ +A +++ + GP+++ + +
Sbjct: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKAL--PDGPVTIVIRR 1318
Score = 36.2 bits (82), Expect = 0.10
Identities = 22/93 (23%), Positives = 45/93 (48%), Gaps = 2/93 (2%)
Query: 249 IVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVN 308
+V V+L E LGI + + GI++ ++ G DGR+ GD +++++D
Sbjct: 353 MVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
Query: 309 FENMSNDDAVRVLREIVSQTGPISLTVAKCWDP 341
++ ++ +L GP+ + V++ DP
Sbjct: 413 VHCLTLNEVYTILSH--CDPGPVPIIVSRHPDP 443
Score = 35.8 bits (81), Expect = 0.13
Identities = 33/130 (25%), Positives = 63/130 (48%), Gaps = 13/130 (10%)
Query: 195 DEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVT- 253
D+DG S L S QS S L+ + ++ + ++ D A+ L+ + VT
Sbjct: 1067 DDDGDHSSLQSG--QSVIS-LLSSEELKKLIEEVKVLDEAT--------LKQLDGIHVTI 1115
Query: 254 LNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMS 313
L+ E LG S+ G + D + I + + G + +G I+ G+ +L +N + + +
Sbjct: 1116 LHKEEGAGLGFSLAGGA-DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
Query: 314 NDDAVRVLRE 323
+ DA+ +LR+
Sbjct: 1175 HHDALAILRQ 1184
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 53.5 bits (127), Expect = 6e-07
Identities = 44/167 (26%), Positives = 77/167 (46%), Gaps = 14/167 (8%)
Query: 192 VDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVT 251
++ DG L + S++S+ K+ R Q + S + I S +S+
Sbjct: 533 LEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVE--SPWRLIRPSVISI---- 586
Query: 252 VTLNMERHHFLGISIVGQSND-RGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFE 310
+ L E+ LG SI G + RG GI++ +I G+ A DGR++ GD +L VN + +
Sbjct: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIK 646
Query: 311 NMSNDDAVRVLREIVS-------QTGPISLTVAKCWDPTPRSYFTVP 350
++ +A+ ++I S +T +S ++ C PT S P
Sbjct: 647 GLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASP 693
Score = 45.8 bits (107), Expect = 1e-04
Identities = 28/76 (36%), Positives = 42/76 (55%), Gaps = 4/76 (5%)
Query: 262 LGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV 320
LGI + G + + R I + + +GGA DGR+ GD LL +N +S+++AV +
Sbjct: 344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAI 403
Query: 321 LREIVSQTGPISLTVA 336
LR S TG + L VA
Sbjct: 404 LR---SATGMVQLVVA 416
Score = 44.3 bits (103), Expect = 4e-04
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 3/77 (3%)
Query: 262 LGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV 320
LG+S+ G +S+ GDG + I + KGGA G IE GD +L +N + + DA +
Sbjct: 2760 LGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNI 2819
Query: 321 LREIVSQTGPISLTVAK 337
++ + GP+ L + K
Sbjct: 2820 MKSV--PEGPVQLLIRK 2834
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/111 (27%), Positives = 48/111 (43%), Gaps = 4/111 (3%)
Query: 234 ASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADG 293
+SS T ++ VTLN E LGI + + GIYI S+ G +
Sbjct: 711 SSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMES 770
Query: 294 RIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPR 344
+ GD +L+VN VN + + +L + GP+ L + + P P+
Sbjct: 771 NLSRGDQILEVNSVNVRHAALSKVHAILSK--CPPGPVRLVIGR--HPNPK 817
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 53.1 bits (126), Expect = 8e-07
Identities = 38/136 (27%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 193 DSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIV-- 250
DS S + +S ++++S L+ + +R R+S+ + + I+
Sbjct: 1566 DSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPG 1625
Query: 251 ---TVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDV 307
T+ ++ R LG+SIVG S D G I I + + GA DGR+ GD +L+VN +
Sbjct: 1626 CETTIEISKGRTG-LGLSIVGGS-DTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGI 1683
Query: 308 NFENMSNDDAVRVLRE 323
+ ++D+A+ VLR+
Sbjct: 1684 DLRKATHDEAINVLRQ 1699
Score = 52.8 bits (125), Expect = 1e-06
Identities = 34/94 (36%), Positives = 50/94 (53%), Gaps = 4/94 (4%)
Query: 262 LGISIVGQSN--DRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVR 319
LG SI+ + D I I S++ GG DGR+ PGD L+ VNDVN EN S ++AV
Sbjct: 710 LGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVE 769
Query: 320 VLREIVSQTGPISLTVAKCWDPTPRSYFTVPRAD 353
L+ + +G + + VAK +P + + D
Sbjct: 770 ALKG--APSGTVRIGVAKPLPLSPEEGYVSAKED 801
Score = 52.0 bits (123), Expect = 2e-06
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 7/87 (8%)
Query: 250 VTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNF 309
+T+ L + LG+SIVG+ ND G +++ I+KGG ADGR+ GD +L VN +
Sbjct: 1724 LTIELQKKPGKGLGLSIVGKRNDTG---VFVSDIVKGGIADADGRLMQGDQILMVNGEDV 1780
Query: 310 ENMSNDDAVRVLR----EIVSQTGPIS 332
N + + +L+ + S T P+S
Sbjct: 1781 RNATQEAVAALLKVSEGSLSSFTFPLS 1807
Score = 51.2 bits (121), Expect = 3e-06
Identities = 41/143 (28%), Positives = 61/143 (42%), Gaps = 13/143 (9%)
Query: 193 DSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTV 252
D+D G +S + + +R+ R ++R + SS ST L +
Sbjct: 307 DTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDAS 366
Query: 253 TLNMERHHF-----------LGISIVGQSNDRG--DGGIYIGSIMKGGAVAADGRIEPGD 299
T E LGI+I G D+ GI++ SI K AV DGRI+ GD
Sbjct: 367 TQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 300 MLLQVNDVNFENMSNDDAVRVLR 322
++ V+ N + +N AV VLR
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLR 449
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/62 (37%), Positives = 40/62 (64%), Gaps = 1/62 (1%)
Query: 262 LGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV 320
LG SIVG + GD IY+ ++ GA + DGR++ GD ++ VN + E +++++AV +
Sbjct: 1968 LGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAI 2027
Query: 321 LR 322
L+
Sbjct: 2028 LK 2029
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/162 (23%), Positives = 76/162 (46%), Gaps = 15/162 (9%)
Query: 170 DVGLPPDSAST--------ALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKR 221
D+ + P S T A+ + E + + E S + SS E + ++
Sbjct: 920 DISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPS---VLPDSAG 976
Query: 222 RRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMER-HHFLGISIVGQSNDRGDGGIYI 280
+ + L Q+ A + + +S T+N+ + + LG+++ S ++ G+ +
Sbjct: 977 KGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTV---SANKDGLGMIV 1033
Query: 281 GSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLR 322
SI+ GGA++ DGRI GD +L +N+ + +++N A +LR
Sbjct: 1034 RSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 40.4 bits (93), Expect = 0.005
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 19/195 (9%)
Query: 149 RRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTE 208
RR ++EA + R D +D L P +AS + + F+ S + T+ L + E
Sbjct: 461 RRGMKQEAELMS---REDVTKDADLSPVNASIIKENYEKDEDFLSSTRN--TNILPTEEE 515
Query: 209 QSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVG 268
L+ + ++A + + I M +N V ++ + F S +G
Sbjct: 516 ---GYPLLSAEIEEIEDAQKQEAALLTKWQRI----MGINYEIVVAHVSK--FSENSGLG 566
Query: 269 QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQT 328
S + G +I S++ G V G++ GD LL+VN + ++ D V +L+E+
Sbjct: 567 ISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKEL---- 622
Query: 329 GPISLTVAKCWDPTP 343
PI +T+ C P
Sbjct: 623 -PIEVTMVCCRRTVP 636
Score = 40.0 bits (92), Expect = 0.007
Identities = 20/64 (31%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 262 LGISIVG-QSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNF-ENMSNDDAVR 319
LG S+VG +S +RG+ GI++ I +G DGR++ D +L +N + +++ A+
Sbjct: 148 LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAIS 207
Query: 320 VLRE 323
+L++
Sbjct: 208 ILQK 211
Score = 40.0 bits (92), Expect = 0.007
Identities = 24/79 (30%), Positives = 42/79 (53%), Gaps = 7/79 (8%)
Query: 252 VTLNMERHHFLGISIVGQ-------SNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQV 304
V L E LGISIVG SN GI+I +++ +G ++PGD +++V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 305 NDVNFENMSNDDAVRVLRE 323
+ ++ + S++ AV +R+
Sbjct: 1212 DGMDLRDASHEQAVEAIRK 1230
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 17/94 (18%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG I+G G+ + +I+ GG GR+ GD +L++ D + MS++ +VL
Sbjct: 267 LGFGIIGGKAT----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVL 322
Query: 322 RE-------------IVSQTGPISLTVAKCWDPT 342
R+ I +T P +L + PT
Sbjct: 323 RQCGNRVKLMIARGAIEERTAPTALGITLSSSPT 356
Score = 37.4 bits (85), Expect = 0.045
Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Query: 259 HHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
H LG+S+ G + DR ++I I GA DGR++ D LL++N S+ +A
Sbjct: 1357 HSGLGLSLAG-NKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
Query: 319 RVLR 322
+++
Sbjct: 1416 SIIK 1419
Score = 32.7 bits (73), Expect = 1.1
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 3/45 (6%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVND 306
LGI+I S + G+ I S+ + G A DGR++ GD +L V+D
Sbjct: 1493 LGIAI---SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDD 1534
Score = 32.0 bits (71), Expect = 1.9
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 4/75 (5%)
Query: 262 LGISIVGQ-SNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRV 320
LGISI G + GD I+I + G A ++ GD ++ + + E M++ AV +
Sbjct: 1844 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 1903
Query: 321 LREIVSQTGPISLTV 335
L+ + +G I + V
Sbjct: 1904 LK---NASGSIEMQV 1915
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 53.1 bits (126), Expect = 8e-07
Identities = 42/149 (28%), Positives = 69/149 (46%), Gaps = 5/149 (3%)
Query: 185 ELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDST 244
E+ ++ + L S+ + T+S +I + + + L+ + S T
Sbjct: 435 EVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQ 494
Query: 245 MSLNIVTVTLNMERHHFLGISIVG-QSNDRG-DGGIYIGSIMKGGAVAADGRIEPGDMLL 302
++ I LN LG+S+ G +S + G D GI+I SI+ GGA DGR+ D L+
Sbjct: 495 LTFEI---PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551
Query: 303 QVNDVNFENMSNDDAVRVLREIVSQTGPI 331
VN + SN +A+ LR +S G I
Sbjct: 552 AVNGESLLGKSNHEAMETLRRSMSMEGNI 580
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/140 (24%), Positives = 68/140 (48%), Gaps = 3/140 (2%)
Query: 200 TSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERH 259
T+ L+ + T + + + R RL + S S + + N + +++++
Sbjct: 330 TANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKG 389
Query: 260 -HFLGISIVGQ-SNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDA 317
LG ++V + S+ G G I++ +I+ GA DGR++ GD +L+VN + + ++
Sbjct: 390 PEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
Query: 318 VRVLREIVSQTGPISLTVAK 337
V +LR Q SL +A+
Sbjct: 450 VAMLRS-TKQGETASLVIAR 468
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 53.1 bits (126), Expect = 8e-07
Identities = 42/149 (28%), Positives = 69/149 (46%), Gaps = 5/149 (3%)
Query: 185 ELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDST 244
E+ ++ + L S+ + T+S +I + + + L+ + S T
Sbjct: 435 EVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQ 494
Query: 245 MSLNIVTVTLNMERHHFLGISIVG-QSNDRG-DGGIYIGSIMKGGAVAADGRIEPGDMLL 302
++ I LN LG+S+ G +S + G D GI+I SI+ GGA DGR+ D L+
Sbjct: 495 LTFEI---PLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLI 551
Query: 303 QVNDVNFENMSNDDAVRVLREIVSQTGPI 331
VN + SN +A+ LR +S G I
Sbjct: 552 AVNGESLLGKSNHEAMETLRRSMSMEGNI 580
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/140 (24%), Positives = 68/140 (48%), Gaps = 3/140 (2%)
Query: 200 TSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERH 259
T+ L+ + T + + + R RL + S S + + N + +++++
Sbjct: 330 TANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKG 389
Query: 260 -HFLGISIVGQ-SNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDA 317
LG ++V + S+ G G I++ +I+ GA DGR++ GD +L+VN + + ++
Sbjct: 390 PEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
Query: 318 VRVLREIVSQTGPISLTVAK 337
V +LR Q SL +A+
Sbjct: 450 VAMLRS-TKQGETASLVIAR 468
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/64 (40%), Positives = 40/64 (62%), Gaps = 3/64 (4%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG +IVG ++ + D GIY+ I + GA A DGR++ GD +L VN + +N+ + DAV
Sbjct: 23 LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAV 82
Query: 319 RVLR 322
+ R
Sbjct: 83 DLFR 86
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/64 (42%), Positives = 41/64 (64%), Gaps = 3/64 (4%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI VG + GD IY+ I++GGA DG+++ GD LL VN+V E +++++AV
Sbjct: 329 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAV 388
Query: 319 RVLR 322
L+
Sbjct: 389 TALK 392
Score = 48.1 bits (113), Expect = 3e-05
Identities = 25/65 (38%), Positives = 40/65 (61%), Gaps = 3/65 (4%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI G +++ D I+I I+ GGA A DGR+ D +L+VN+V+ ++++ AV
Sbjct: 234 LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAV 293
Query: 319 RVLRE 323
L+E
Sbjct: 294 EALKE 298
Score = 38.1 bits (87), Expect = 0.027
Identities = 20/61 (32%), Positives = 31/61 (50%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I+I I+ GG G + GD ++ VN V+ S++ A L
Sbjct: 476 LGFNIVGGEDGEG---IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532
Query: 322 R 322
+
Sbjct: 533 K 533
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/64 (42%), Positives = 41/64 (64%), Gaps = 3/64 (4%)
Query: 262 LGISI---VGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI VG + GD IY+ I++GGA DG+++ GD LL VN+V E +++++AV
Sbjct: 329 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAV 388
Query: 319 RVLR 322
L+
Sbjct: 389 TALK 392
Score = 48.1 bits (113), Expect = 3e-05
Identities = 25/65 (38%), Positives = 40/65 (61%), Gaps = 3/65 (4%)
Query: 262 LGISIVGQSNDR---GDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAV 318
LG SI G +++ D I+I I+ GGA A DGR+ D +L+VN+V+ ++++ AV
Sbjct: 234 LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAV 293
Query: 319 RVLRE 323
L+E
Sbjct: 294 EALKE 298
Score = 38.1 bits (87), Expect = 0.027
Identities = 20/61 (32%), Positives = 31/61 (50%), Gaps = 3/61 (4%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG +IVG + G I+I I+ GG G + GD ++ VN V+ S++ A L
Sbjct: 476 LGFNIVGGEDGEG---IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532
Query: 322 R 322
+
Sbjct: 533 K 533
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/90 (36%), Positives = 51/90 (56%), Gaps = 6/90 (6%)
Query: 249 IVTVTLNMERHHFLGISIVGQSNDRGDG-GIYIGSIMKGGAVAADGRIEPGDMLLQVNDV 307
I+TVTL ++ + +G+SIV D GIY+ S++KGGA DGR+ GD LL V+
Sbjct: 1006 IITVTL--KKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1063
Query: 308 NFENMSNDDAVRVLREIVSQTGPISLTVAK 337
+ +S + A ++ S ++L VAK
Sbjct: 1064 SLVGLSQERAAELMTRTSS---VVTLEVAK 1090
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/90 (36%), Positives = 51/90 (56%), Gaps = 6/90 (6%)
Query: 249 IVTVTLNMERHHFLGISIVGQSNDRGDG-GIYIGSIMKGGAVAADGRIEPGDMLLQVNDV 307
I+TVTL ++ + +G+SIV D GIY+ S++KGGA DGR+ GD LL V+
Sbjct: 1007 IITVTL--KKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1064
Query: 308 NFENMSNDDAVRVLREIVSQTGPISLTVAK 337
+ +S + A ++ S ++L VAK
Sbjct: 1065 SLVGLSQERAAELMTRTSS---VVTLEVAK 1091
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/90 (36%), Positives = 51/90 (56%), Gaps = 6/90 (6%)
Query: 249 IVTVTLNMERHHFLGISIVGQSNDRGDG-GIYIGSIMKGGAVAADGRIEPGDMLLQVNDV 307
I+TVTL ++ + +G+SIV D GIY+ S++KGGA DGR+ GD LL V+
Sbjct: 991 IITVTL--KKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1048
Query: 308 NFENMSNDDAVRVLREIVSQTGPISLTVAK 337
+ +S + A ++ S ++L VAK
Sbjct: 1049 SLVGLSQERAAELMTRTSS---VVTLEVAK 1075
>gi|46559761 PDZ domain containing 4 [Homo sapiens]
Length = 769
Score = 50.4 bits (119), Expect = 5e-06
Identities = 27/76 (35%), Positives = 45/76 (59%), Gaps = 4/76 (5%)
Query: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
LG+ + +++D D GIY+G + A DGRI GD ++Q+N V+ +N ++AV +L
Sbjct: 142 LGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAIL 199
Query: 322 REIVSQTGPISLTVAK 337
+ + ISL VA+
Sbjct: 200 SQ--EENTNISLLVAR 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,341,092
Number of Sequences: 37866
Number of extensions: 1741275
Number of successful extensions: 13283
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 872
Number of HSP's that attempted gapping in prelim test: 9301
Number of HSP's gapped (non-prelim): 3930
length of query: 670
length of database: 18,247,518
effective HSP length: 109
effective length of query: 561
effective length of database: 14,120,124
effective search space: 7921389564
effective search space used: 7921389564
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.