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Search of human proteins with 122937331
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937331 60 kDa lysophospholipase [Homo sapiens]
(579 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937331 60 kDa lysophospholipase [Homo sapiens] 1144 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 74 3e-13
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 72 1e-12
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 72 1e-12
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 72 1e-12
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 72 1e-12
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 72 2e-12
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 72 2e-12
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 70 5e-12
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 70 5e-12
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 70 5e-12
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 69 9e-12
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 69 2e-11
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 69 2e-11
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 69 2e-11
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 69 2e-11
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 69 2e-11
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 67 6e-11
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 66 8e-11
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 66 8e-11
gi|19924156 regulatory factor X-associated ankyrin-containing pr... 65 1e-10
gi|4506499 regulatory factor X-associated ankyrin-containing pro... 65 1e-10
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 65 1e-10
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 65 2e-10
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 65 2e-10
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 65 2e-10
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 65 2e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 65 2e-10
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 65 2e-10
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 64 3e-10
>gi|122937331 60 kDa lysophospholipase [Homo sapiens]
Length = 579
Score = 1144 bits (2958), Expect = 0.0
Identities = 579/579 (100%), Positives = 579/579 (100%)
Query: 1 MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDT 60
MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDT
Sbjct: 1 MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDT 60
Query: 61 LVLPPASRNQRILYTVLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMA 120
LVLPPASRNQRILYTVLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMA
Sbjct: 61 LVLPPASRNQRILYTVLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMA 120
Query: 121 FAASMLSFMLENLQKTVILTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQL 180
FAASMLSFMLENLQKTVILTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQL
Sbjct: 121 FAASMLSFMLENLQKTVILTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQL 180
Query: 181 FRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGKAGLVVHSSMEQDVGL 240
FRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGKAGLVVHSSMEQDVGL
Sbjct: 181 FRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGKAGLVVHSSMEQDVGL 240
Query: 241 LRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCL 300
LRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCL
Sbjct: 241 LRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCL 300
Query: 301 QGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEM 360
QGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEM
Sbjct: 301 QGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEM 360
Query: 361 TPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQAL 420
TPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQAL
Sbjct: 361 TPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQAL 420
Query: 421 VELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHP 480
VELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHP
Sbjct: 421 VELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHP 480
Query: 481 GVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHV 540
GVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHV
Sbjct: 481 GVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHV 540
Query: 541 AEAAGNLAVVAFLQSLEGAVGAQAPCPEPSCFQEVLPGV 579
AEAAGNLAVVAFLQSLEGAVGAQAPCPEPSCFQEVLPGV
Sbjct: 541 AEAAGNLAVVAFLQSLEGAVGAQAPCPEPSCFQEVLPGV 579
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 74.3 bits (181), Expect = 3e-13
Identities = 48/151 (31%), Positives = 78/151 (51%), Gaps = 1/151 (0%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+L AA++G ++ + LV G+DL + D +G TPL AAR GHT+ V L+ G ++N
Sbjct: 547 TLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINH 606
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQ 522
D DG++ L A G H V+ L AG + + ++ T L A+ + + Q
Sbjct: 607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD-ADSRTALRAAAWGGHEDIVLNLLQ 665
Query: 523 AGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
GA++ + +G +AL A G+ +V L
Sbjct: 666 HGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Score = 70.5 bits (171), Expect = 4e-12
Identities = 57/173 (32%), Positives = 83/173 (47%), Gaps = 6/173 (3%)
Query: 385 LSLSGSQEADAL-RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
L L G + D N P LA AA G + L+ G+ + +D G+T L A+
Sbjct: 766 LLLEGGADVDHTDNNGRTPLLA--AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASA 823
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
G+ E V LL RG+D N RD G++PL +A H + L E GA T E++ G
Sbjct: 824 QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA--RTNEIDNDGR 881
Query: 504 ELCRLA-YRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
LA + +Q+ + +++ Q GYDG +AL VA G+ +V L S
Sbjct: 882 IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934
Score = 68.9 bits (167), Expect = 1e-11
Identities = 45/150 (30%), Positives = 73/150 (48%), Gaps = 1/150 (0%)
Query: 397 RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQR 456
R AL + C A G + L++ G+++ D +G TPL AA GH + V +LL+
Sbjct: 711 RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEG 770
Query: 457 GVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEG 516
G DV+ D +G +PLL A H V+ L GA++ + + E T L + + ++E
Sbjct: 771 GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSID-SEGRTVLSIASAQGNVEV 829
Query: 517 LQVWWQAGADLGQPGYDGHSALHVAEAAGN 546
++ G D G + LH+A G+
Sbjct: 830 VRTLLDRGLDENHRDDAGWTPLHMAAFEGH 859
Score = 65.1 bits (157), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 6/156 (3%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
+AA G E + AL+ G + D + +T L AAA GGH + V LLQ G +VN D +
Sbjct: 617 SAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNE 676
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEE----AGTELCRLAYRADLEGLQVWWQ 522
G + L+ A H ++ L + GA ++ ++++ + LC A + + +
Sbjct: 677 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 736
Query: 523 AGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEG 558
GA++ DG + L VA G++ VV L LEG
Sbjct: 737 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL--LEG 770
Score = 64.3 bits (155), Expect = 3e-10
Identities = 47/150 (31%), Positives = 76/150 (50%), Gaps = 8/150 (5%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AAA G + + L++ G+++ D G+T L AAA GH E V LL G +VN D D
Sbjct: 650 AAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVD 709
Query: 467 GFSPLLLAV------RGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVW 520
G + L +A +G H V+ LL + GA + + ++ T L AY ++ + +
Sbjct: 710 GRTALSVAALCVPASKG-HASVVSLLIDRGAEVDHCD-KDGMTPLLVAAYEGHVDVVDLL 767
Query: 521 WQAGADLGQPGYDGHSALHVAEAAGNLAVV 550
+ GAD+ +G + L A + G+ +VV
Sbjct: 768 LEGGADVDHTDNNGRTPLLAAASMGHASVV 797
Score = 62.4 bits (150), Expect = 1e-09
Identities = 47/157 (29%), Positives = 69/157 (43%), Gaps = 2/157 (1%)
Query: 421 VELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHP 480
+E G+++ D G+T LH + GH E V +L+ DVN D + S L A H
Sbjct: 966 LENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025
Query: 481 GVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHV 540
V+ LL E GA + + T LC A ++ +QV + GAD G +A+ V
Sbjct: 1026 KVVQLLIEHGAVVD-HTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRV 1084
Query: 541 AEAAGNLAVVAFLQSLEGAVGAQAPCPEPSCFQEVLP 577
A G+ ++ L+ GA P P E P
Sbjct: 1085 AAKNGHSQIIKLLEKY-GASSLNGCSPSPVHTMEQKP 1120
Score = 60.8 bits (146), Expect = 3e-09
Identities = 39/136 (28%), Positives = 66/136 (48%), Gaps = 1/136 (0%)
Query: 415 EALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLA 474
++++ L++ G+ + D NG+T L AA G + V +L+ RG D+ D G +PL LA
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 475 VRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDG 534
R H V+ L GA+++ + ++ T L A+ E + AG + D
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTD-QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 535 HSALHVAEAAGNLAVV 550
+AL A G+ +V
Sbjct: 645 RTALRAAAWGGHEDIV 660
Score = 59.7 bits (143), Expect = 7e-09
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 1/155 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G +AL+E G+ +D +G+ P A++ GH + V +LL+ +++ R DG
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG 913
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L +A H ++ LL GA ++ ++ + T L LA L + + + GA++
Sbjct: 914 RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT-LYILALENQLTMAEYFLENGANV 972
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGA 562
+G +ALHV+ G++ +V L + V A
Sbjct: 973 EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007
Score = 55.8 bits (133), Expect = 1e-07
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + +Q L+E S++ ++G+ L AA GH + V +L G DVN +D DG
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADG 946
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
L + + E GA++ + E T L ++ +E +QV AD+
Sbjct: 947 RPTLYILALENQLTMAEYFLENGANVEASD-AEGRTALHVSCWQGHMEMVQVLIAYHADV 1005
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
+ SAL A G++ VV L
Sbjct: 1006 NAADNEKRSALQSAAWQGHVKVVQLL 1031
Score = 52.4 bits (124), Expect = 1e-06
Identities = 31/86 (36%), Positives = 47/86 (54%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
+AA G V+ +Q L+E G+ + G T L AA+ GH + V +LL+ G D N D
Sbjct: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGAS 492
G + + +A + H +I LL + GAS
Sbjct: 1078 GRTAMRVAAKNGHSQIIKLLEKYGAS 1103
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 2/92 (2%)
Query: 367 ERRPSLQGNTLGGGVSWL-LSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGS 425
E+R +LQ G V + L + D N +L C AA G ++ +Q L+E G+
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATAL-CIAAQEGHIDVVQVLLEHGA 1069
Query: 426 DLGLVDFNGQTPLHAAARGGHTEAVTMLLQRG 457
D D G+T + AA+ GH++ + +L + G
Sbjct: 1070 DPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 72.0 bits (175), Expect = 1e-12
Identities = 52/158 (32%), Positives = 76/158 (48%), Gaps = 3/158 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G+V L+ G+ + NG TPLH A++ G+T V +LL RG ++ + DG
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H V+ LL E GA L + + G +A + D +E ++ Q A
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLAR--TKNGLSPLHMAAQGDHVECVKHLLQHKAP 336
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
+ D +ALHVA G+ V L A+A
Sbjct: 337 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374
Score = 66.2 bits (160), Expect = 8e-11
Identities = 75/242 (30%), Positives = 104/242 (42%), Gaps = 45/242 (18%)
Query: 357 RGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEA 416
R +TP V +R GNT V LL G +A R+ L P L CAA +G +
Sbjct: 243 RNGITPLHVASKR----GNT--NMVKLLLDRGGQIDAKT-RDGLTP-LHCAA-RSGHDQV 293
Query: 417 LQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDV---------------- 460
++ L+E G+ L NG +PLH AA+G H E V LLQ V
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 353
Query: 461 -----------------NTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG- 502
N R +GF+PL +A + V+ LL + GAS+ Q + E+G
Sbjct: 354 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI--QAITESGL 411
Query: 503 TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGA 562
T + A+ L + + Q GA G +ALH+A AG + VV L V A
Sbjct: 412 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 471
Query: 563 QA 564
+A
Sbjct: 472 RA 473
Score = 63.2 bits (152), Expect = 6e-10
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG VE ++ L+ G+ + QTPLH A+R G TE V +LLQ + T+G
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
++PL ++ R V +L EAGA+ S ++ T L A L+ ++ Q A
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G +G + LHVA N V L
Sbjct: 569 DSAGKNGLTPLHVAAHYDNQKVALLL 594
Score = 60.5 bits (145), Expect = 4e-09
Identities = 55/216 (25%), Positives = 96/216 (44%), Gaps = 16/216 (7%)
Query: 344 SLDVRKELLTK----DLRGE--MTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALR 397
SLDV K LL + D G+ +TP V + + V+ LL G+ +
Sbjct: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK-------VALLLLEKGASPHATAK 606
Query: 398 NALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRG 457
N P AA ++ L+ G++ +V G TPLH A++ GHT+ VT+LL +G
Sbjct: 607 NGYTP--LHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664
Query: 458 VDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGL 517
+++ G + L LA + V +L + GA + T L + +++ +
Sbjct: 665 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-QDAHTKLGYTPLIVACHYGNVKMV 723
Query: 518 QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ GA++ +G++ LH A G+ ++ L
Sbjct: 724 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Score = 60.1 bits (144), Expect = 5e-09
Identities = 42/163 (25%), Positives = 77/163 (47%), Gaps = 17/163 (10%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ AG E ++ LV+ G+++ NG TPL+ AA+ H + V LL+ G + +T DG
Sbjct: 83 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142
Query: 468 FSPLLLAVRGRHPGVIGLLREAGAS----------LSTQELEEAGTELCRLAYRADLEGL 517
F+PL +A++ H + +L E + ++ ++ L + + AD++
Sbjct: 143 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202
Query: 518 QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+ + + G + LH+A GN+ V L + AV
Sbjct: 203 MM-------VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
Score = 59.7 bits (143), Expect = 7e-09
Identities = 32/88 (36%), Positives = 48/88 (54%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G V +Q L+ GS + G T LH A+ G E V +L++ G ++N + +G
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLST 495
F+PL +A + H V+ L E GA+ ST
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQST 137
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG+++ + ++ G D+ + NG LH AA+ GH V LL RG V++ G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L +A V+ +L + GA+++ Q + T L A ++ ++ + GA+
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQ 135
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L VA G+ VA L
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAIL 161
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/88 (32%), Positives = 48/88 (54%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A H G+V+ + L++ G+++ NG TPLH AA+ GHT + +LLQ G N +G
Sbjct: 714 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLST 495
+ L +A R + V+ L+ ++T
Sbjct: 774 NTALAIAKRLGYISVVDTLKVVTEEVTT 801
Score = 54.3 bits (129), Expect = 3e-07
Identities = 45/170 (26%), Positives = 75/170 (44%), Gaps = 4/170 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + A AL +AC ++ ++ LV+ G+ + + +G TP+H AA
Sbjct: 363 LLDKRANPNARALNGFTPLHIACKKNR---IKVMELLVKYGASIQAITESGLTPIHVAAF 419
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V +LLQ G + + G + L +A R V+ L GA + + EE T
Sbjct: 420 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-T 478
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
L + E +Q+ Q A +G++ LH++ G + V + L
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Score = 53.1 bits (126), Expect = 7e-07
Identities = 42/146 (28%), Positives = 64/146 (43%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
+A G V+ L+E G+ L G TPLH AA+ G + +LLQR ++ +G
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A + V LL E GAS + T L A + ++ GA+
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LH+A G+ +V L
Sbjct: 635 NIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 49.7 bits (117), Expect = 7e-06
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G + L++ ++ NG TPLH A + + + +L++ G + G
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+P+ +A H ++ LL + GAS + T L A +E ++ + GA +
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNI-RGETALHMAARAGQVEVVRCLLRNGALV 469
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
+ + LH+A G +V L
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLL 495
Score = 46.6 bits (109), Expect = 6e-05
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA V L + G+D G TPL A G+ + V LL++G +VN + +G
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 740
Query: 468 FSPLLLAVRGRHPGVIGLLREAGA--SLSTQELEEAGTELCRLAYRADLEGLQV 519
++PL A + H +I +L + GA + +T A RL Y + ++ L+V
Sbjct: 741 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKV 794
Score = 46.2 bits (108), Expect = 8e-05
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 433 NGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGAS 492
+G TPLH AA G+ T+LL RG V+ +G +PL +A + + ++ LL + G
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
Query: 493 LSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAF 552
+ + + T L A + +++ + GA L +G S LH+A ++ V
Sbjct: 271 IDA-KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329
Query: 553 L 553
L
Sbjct: 330 L 330
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 72.0 bits (175), Expect = 1e-12
Identities = 52/158 (32%), Positives = 76/158 (48%), Gaps = 3/158 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G+V L+ G+ + NG TPLH A++ G+T V +LL RG ++ + DG
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H V+ LL E GA L + + G +A + D +E ++ Q A
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLAR--TKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
+ D +ALHVA G+ V L A+A
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Score = 66.2 bits (160), Expect = 8e-11
Identities = 75/242 (30%), Positives = 104/242 (42%), Gaps = 45/242 (18%)
Query: 357 RGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEA 416
R +TP V +R GNT V LL G +A R+ L P L CAA +G +
Sbjct: 264 RNGITPLHVASKR----GNT--NMVKLLLDRGGQIDAKT-RDGLTP-LHCAA-RSGHDQV 314
Query: 417 LQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDV---------------- 460
++ L+E G+ L NG +PLH AA+G H E V LLQ V
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 374
Query: 461 -----------------NTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG- 502
N R +GF+PL +A + V+ LL + GAS+ Q + E+G
Sbjct: 375 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI--QAITESGL 432
Query: 503 TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGA 562
T + A+ L + + Q GA G +ALH+A AG + VV L V A
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492
Query: 563 QA 564
+A
Sbjct: 493 RA 494
Score = 63.2 bits (152), Expect = 6e-10
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG VE ++ L+ G+ + QTPLH A+R G TE V +LLQ + T+G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
++PL ++ R V +L EAGA+ S ++ T L A L+ ++ Q A
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G +G + LHVA N V L
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLL 615
Score = 60.5 bits (145), Expect = 4e-09
Identities = 55/216 (25%), Positives = 96/216 (44%), Gaps = 16/216 (7%)
Query: 344 SLDVRKELLTK----DLRGE--MTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALR 397
SLDV K LL + D G+ +TP V + + V+ LL G+ +
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK-------VALLLLEKGASPHATAK 627
Query: 398 NALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRG 457
N P AA ++ L+ G++ +V G TPLH A++ GHT+ VT+LL +G
Sbjct: 628 NGYTP--LHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 458 VDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGL 517
+++ G + L LA + V +L + GA + T L + +++ +
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-QDAHTKLGYTPLIVACHYGNVKMV 744
Query: 518 QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ GA++ +G++ LH A G+ ++ L
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Score = 60.1 bits (144), Expect = 5e-09
Identities = 42/163 (25%), Positives = 77/163 (47%), Gaps = 17/163 (10%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ AG E ++ LV+ G+++ NG TPL+ AA+ H + V LL+ G + +T DG
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 468 FSPLLLAVRGRHPGVIGLLREAGAS----------LSTQELEEAGTELCRLAYRADLEGL 517
F+PL +A++ H + +L E + ++ ++ L + + AD++
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 518 QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+ + + G + LH+A GN+ V L + AV
Sbjct: 224 MM-------VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Score = 59.7 bits (143), Expect = 7e-09
Identities = 32/88 (36%), Positives = 48/88 (54%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G V +Q L+ GS + G T LH A+ G E V +L++ G ++N + +G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLST 495
F+PL +A + H V+ L E GA+ ST
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQST 158
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG+++ + ++ G D+ + NG LH AA+ GH V LL RG V++ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L +A V+ +L + GA+++ Q + T L A ++ ++ + GA+
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L VA G+ VA L
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAIL 182
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/88 (32%), Positives = 48/88 (54%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A H G+V+ + L++ G+++ NG TPLH AA+ GHT + +LLQ G N +G
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLST 495
+ L +A R + V+ L+ ++T
Sbjct: 795 NTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 54.3 bits (129), Expect = 3e-07
Identities = 45/170 (26%), Positives = 75/170 (44%), Gaps = 4/170 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + A AL +AC ++ ++ LV+ G+ + + +G TP+H AA
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNR---IKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V +LLQ G + + G + L +A R V+ L GA + + EE T
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-T 499
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
L + E +Q+ Q A +G++ LH++ G + V + L
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Score = 53.1 bits (126), Expect = 7e-07
Identities = 42/146 (28%), Positives = 64/146 (43%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
+A G V+ L+E G+ L G TPLH AA+ G + +LLQR ++ +G
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A + V LL E GAS + T L A + ++ GA+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LH+A G+ +V L
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 49.7 bits (117), Expect = 7e-06
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G + L++ ++ NG TPLH A + + + +L++ G + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+P+ +A H ++ LL + GAS + T L A +E ++ + GA +
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNI-RGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
+ + LH+A G +V L
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLL 516
Score = 46.6 bits (109), Expect = 6e-05
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA V L + G+D G TPL A G+ + V LL++G +VN + +G
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 468 FSPLLLAVRGRHPGVIGLLREAGA--SLSTQELEEAGTELCRLAYRADLEGLQV 519
++PL A + H +I +L + GA + +T A RL Y + ++ L+V
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKV 815
Score = 46.2 bits (108), Expect = 8e-05
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 433 NGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGAS 492
+G TPLH AA G+ T+LL RG V+ +G +PL +A + + ++ LL + G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 493 LSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAF 552
+ + + T L A + +++ + GA L +G S LH+A ++ V
Sbjct: 292 IDA-KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 553 L 553
L
Sbjct: 351 L 351
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 72.0 bits (175), Expect = 1e-12
Identities = 52/158 (32%), Positives = 76/158 (48%), Gaps = 3/158 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G+V L+ G+ + NG TPLH A++ G+T V +LL RG ++ + DG
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H V+ LL E GA L + + G +A + D +E ++ Q A
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLAR--TKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
+ D +ALHVA G+ V L A+A
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Score = 66.2 bits (160), Expect = 8e-11
Identities = 75/242 (30%), Positives = 104/242 (42%), Gaps = 45/242 (18%)
Query: 357 RGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEA 416
R +TP V +R GNT V LL G +A R+ L P L CAA +G +
Sbjct: 264 RNGITPLHVASKR----GNT--NMVKLLLDRGGQIDAKT-RDGLTP-LHCAA-RSGHDQV 314
Query: 417 LQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDV---------------- 460
++ L+E G+ L NG +PLH AA+G H E V LLQ V
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 374
Query: 461 -----------------NTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG- 502
N R +GF+PL +A + V+ LL + GAS+ Q + E+G
Sbjct: 375 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI--QAITESGL 432
Query: 503 TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGA 562
T + A+ L + + Q GA G +ALH+A AG + VV L V A
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492
Query: 563 QA 564
+A
Sbjct: 493 RA 494
Score = 63.2 bits (152), Expect = 6e-10
Identities = 49/146 (33%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG VE ++ L+ G+ + QTPLH A+R G TE V +LLQ + T+G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
++PL ++ R V +L EAGA+ S ++ T L A L+ ++ Q A
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G +G + LHVA N V L
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLL 615
Score = 60.5 bits (145), Expect = 4e-09
Identities = 55/216 (25%), Positives = 96/216 (44%), Gaps = 16/216 (7%)
Query: 344 SLDVRKELLTK----DLRGE--MTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALR 397
SLDV K LL + D G+ +TP V + + V+ LL G+ +
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK-------VALLLLEKGASPHATAK 627
Query: 398 NALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRG 457
N P AA ++ L+ G++ +V G TPLH A++ GHT+ VT+LL +G
Sbjct: 628 NGYTP--LHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 458 VDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGL 517
+++ G + L LA + V +L + GA + T L + +++ +
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD-QDAHTKLGYTPLIVACHYGNVKMV 744
Query: 518 QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ GA++ +G++ LH A G+ ++ L
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Score = 60.1 bits (144), Expect = 5e-09
Identities = 42/163 (25%), Positives = 77/163 (47%), Gaps = 17/163 (10%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ AG E ++ LV+ G+++ NG TPL+ AA+ H + V LL+ G + +T DG
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 468 FSPLLLAVRGRHPGVIGLLREAGAS----------LSTQELEEAGTELCRLAYRADLEGL 517
F+PL +A++ H + +L E + ++ ++ L + + AD++
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 518 QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+ + + G + LH+A GN+ V L + AV
Sbjct: 224 MM-------VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Score = 59.7 bits (143), Expect = 7e-09
Identities = 32/88 (36%), Positives = 48/88 (54%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G V +Q L+ GS + G T LH A+ G E V +L++ G ++N + +G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLST 495
F+PL +A + H V+ L E GA+ ST
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQST 158
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG+++ + ++ G D+ + NG LH AA+ GH V LL RG V++ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L +A V+ +L + GA+++ Q + T L A ++ ++ + GA+
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L VA G+ VA L
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAIL 182
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/88 (32%), Positives = 48/88 (54%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A H G+V+ + L++ G+++ NG TPLH AA+ GHT + +LLQ G N +G
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLST 495
+ L +A R + V+ L+ ++T
Sbjct: 795 NTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 54.3 bits (129), Expect = 3e-07
Identities = 45/170 (26%), Positives = 75/170 (44%), Gaps = 4/170 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + A AL +AC ++ ++ LV+ G+ + + +G TP+H AA
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNR---IKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V +LLQ G + + G + L +A R V+ L GA + + EE T
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ-T 499
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
L + E +Q+ Q A +G++ LH++ G + V + L
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Score = 53.1 bits (126), Expect = 7e-07
Identities = 42/146 (28%), Positives = 64/146 (43%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
+A G V+ L+E G+ L G TPLH AA+ G + +LLQR ++ +G
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A + V LL E GAS + T L A + ++ GA+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LH+A G+ +V L
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 49.7 bits (117), Expect = 7e-06
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G + L++ ++ NG TPLH A + + + +L++ G + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+P+ +A H ++ LL + GAS + T L A +E ++ + GA +
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNI-RGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
+ + LH+A G +V L
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLL 516
Score = 46.6 bits (109), Expect = 6e-05
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA V L + G+D G TPL A G+ + V LL++G +VN + +G
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 468 FSPLLLAVRGRHPGVIGLLREAGA--SLSTQELEEAGTELCRLAYRADLEGLQV 519
++PL A + H +I +L + GA + +T A RL Y + ++ L+V
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKV 815
Score = 46.2 bits (108), Expect = 8e-05
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 433 NGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGAS 492
+G TPLH AA G+ T+LL RG V+ +G +PL +A + + ++ LL + G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 493 LSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAF 552
+ + + T L A + +++ + GA L +G S LH+A ++ V
Sbjct: 292 IDA-KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 553 L 553
L
Sbjct: 351 L 351
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 72.0 bits (175), Expect = 1e-12
Identities = 54/167 (32%), Positives = 84/167 (50%), Gaps = 2/167 (1%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL SG + D R++ +L AA+AG ++ ++ LV G+D+ L +G T L AA+
Sbjct: 30 LLLNSGRVDVDC-RDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQ 88
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH + V L G R DG + LL A + H V+ L + GA++ Q L + T
Sbjct: 89 QGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQ-LYDGAT 147
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVV 550
L A L+ +++ +GA + QP DG + L +A G+ VV
Sbjct: 148 ALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
Score = 61.6 bits (148), Expect = 2e-09
Identities = 44/147 (29%), Positives = 72/147 (48%), Gaps = 2/147 (1%)
Query: 408 AAHAGDVEALQALVELGS-DLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA G++ L+ L+ G D+ D +G T L AA GH + V L+ +G D+N +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGAD 526
G + L A + H V+ L GAS + ++ GT L + ++ ++ + GA+
Sbjct: 79 GTTALFFAAQQGHNDVVRFLFGFGASTEFRT-KDGGTALLAASQYGHMQVVETLLKHGAN 137
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ YDG +AL +A G L V+ L
Sbjct: 138 IHDQLYDGATALFLAAQGGYLDVIRLL 164
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/147 (28%), Positives = 75/147 (51%), Gaps = 2/147 (1%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA+ G ++ ++ L++ G+++ ++G T L AA+GG+ + + +LL G VN D
Sbjct: 118 AASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQD 177
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGAD 526
G +PL +A + H V+ ++ GA + T L + A + + ++ +
Sbjct: 178 GTAPLWIASQMGHSEVVRVMLLRGADRDAAR-NDGTTALLKAANKGYNDVIKELLKFSPT 236
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
LG +G SALH A +GN+ VA L
Sbjct: 237 LGIL-KNGTSALHAAVLSGNIKTVALL 262
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/150 (27%), Positives = 67/150 (44%), Gaps = 7/150 (4%)
Query: 338 LGQPGLSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALR 397
L G LDV + LL + + P + P + +G + L + DA R
Sbjct: 151 LAAQGGYLDVIRLLLASGAK--VNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAAR 208
Query: 398 NALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRG 457
N +L AA+ G + ++ L++ LG++ NG + LHAA G+ + V +LL+ G
Sbjct: 209 NDGTTALL-KAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLSGNIKTVALLLEAG 266
Query: 458 VDVNTRDTDGFSPLLLAVRGRHPGVIGLLR 487
D + R+ P L R ++ LLR
Sbjct: 267 ADPSLRNKANELPAELTKNER---ILRLLR 293
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL++ + E ++ + P +A AA+ G V+ ++ L+ +D+ G T L A
Sbjct: 286 LLAMHANVEDRGIKGDITPLMA--AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GG+ + V +LL+ G + + +G +PL+ A H V LL E GA ++T E +
Sbjct: 344 GGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKES 403
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
L Y+ LE ++ +AGAD + H+AL A G++ V L GAQ
Sbjct: 404 ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----SGAQ 459
Query: 564 APCPEPS 570
P S
Sbjct: 460 VNMPADS 466
Score = 66.2 bits (160), Expect = 8e-11
Identities = 46/149 (30%), Positives = 74/149 (49%), Gaps = 7/149 (4%)
Query: 381 VSWLLSLSGSQE--ADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPL 438
V +LL QE D + AL+ AC H VE + L++ G+ + + + ++PL
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALME--ACMDGH---VEVARLLLDSGAQVNMPADSFESPL 471
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQEL 498
AA GGH E +L++RG + + +G++PL+ A R H ++ LL GA+++ Q
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531
Query: 499 EEAGTELCRLAYRADLEGLQVWWQAGADL 527
E T L LE +AGAD+
Sbjct: 532 ETQETALTLACCGGFLEVADFLIKAGADI 560
Score = 63.2 bits (152), Expect = 6e-10
Identities = 37/121 (30%), Positives = 56/121 (46%)
Query: 433 NGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGAS 492
N T L A GGH E V LL+RG + RD GF+PL+LA H GV+ +L + GA
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141
Query: 493 LSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAF 552
+ Q T L E +++ GA+ ++ L +A + G + ++
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
Query: 553 L 553
L
Sbjct: 1202 L 1202
Score = 60.1 bits (144), Expect = 5e-09
Identities = 49/152 (32%), Positives = 72/152 (47%), Gaps = 8/152 (5%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+LAC G +E L++ G+D ++ TPL AA+ GH E V LL G +V+
Sbjct: 539 TLACCG---GFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQ 522
G + L A H V +L +AGA L E E T L + A + +Q
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLE-HESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 523 AGADLGQ-PGYDGHSALHVAEAAGNLAVVAFL 553
GA++ + + H+ L +A A G+LAVV L
Sbjct: 652 KGANVNRTTANNDHTVLSLACAGGHLAVVELL 683
Score = 59.3 bits (142), Expect = 9e-09
Identities = 64/211 (30%), Positives = 91/211 (43%), Gaps = 44/211 (20%)
Query: 381 VSWLLSLSGSQ---EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTP 437
V+ LL SG+Q AD+ + L AA G VE L+E G+ L V+ G TP
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLT-----LAACGGHVELAALLIERGASLEEVNDEGYTP 503
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTD------------GF----------------- 468
L AAR GH E V +LL +G ++N + + GF
Sbjct: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG 563
Query: 469 --SPLLLAVRGRHPGVIGLLREAGASL--STQELEEAGTELCRLAYRADLEGLQVWWQAG 524
+PL+ A + H ++ L AGA++ +T + A T C + + V QAG
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT---DVADVLLQAG 620
Query: 525 ADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
ADL G + L A AG++ V FL S
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Score = 59.3 bits (142), Expect = 9e-09
Identities = 41/146 (28%), Positives = 64/146 (43%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G +E ++ L+ G+++ G T L A GHT+ +LLQ G D+ G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL+ A R H + L GA+++ T L L +++ GAD
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L A G+ +VV +L
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYL 716
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/168 (31%), Positives = 76/168 (45%), Gaps = 15/168 (8%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDV-- 460
+LACA H E +Q L+E G+ + D G TPL AA GH V +LL G D+
Sbjct: 1088 TLACAGGHE---ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 461 ---NTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGL 517
T+DT PL LA G V+ LL GA+ + + + T L A + +
Sbjct: 1145 QSERTKDT----PLSLACSGGRQEVVELLLARGANKEHRNVSDY-TPLSLAASGGYVNII 1199
Query: 518 QVWWQAGADLGQPGYD--GHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
++ AGA++ G S L +A G+ A V L + + AQ
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/149 (29%), Positives = 75/149 (50%), Gaps = 3/149 (2%)
Query: 408 AAHAGDVEALQALVELGSDL-GLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA AG V ++ L++ G+D+ + TPL A GG E V +LL RG + R+
Sbjct: 1123 AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWWQAGA 525
++PL LA G + +I +L AGA ++++ + G + L A +++ G+
Sbjct: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242
Query: 526 DL-GQPGYDGHSALHVAEAAGNLAVVAFL 553
D+ Q + ++AL +A G VV+ L
Sbjct: 1243 DINAQIETNRNTALTLACFQGRTEVVSLL 1271
Score = 54.3 bits (129), Expect = 3e-07
Identities = 43/148 (29%), Positives = 72/148 (48%), Gaps = 2/148 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGL-VDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA G A++ L+++GSD+ ++ N T L A G TE V++LL R +V R
Sbjct: 1225 AAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKT 1284
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEA-GTELCRLAYRADLEGLQVWWQAGA 525
G +PL+ A G + V +L + GA ++ + + T L A + + ++ GA
Sbjct: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ G++ L +A G+L VV L
Sbjct: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/79 (35%), Positives = 42/79 (53%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + + L+ G+ + + + G TPL AA GGH + V +L+Q G DV+ D
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Query: 468 FSPLLLAVRGRHPGVIGLL 486
+PL+ A R H V+ L
Sbjct: 1387 ITPLMAAFRKGHVKVVRYL 1405
Score = 50.4 bits (119), Expect = 4e-06
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 5/119 (4%)
Query: 381 VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGL--VDFNGQTPL 438
VS LL + E A + L P + AA G E + L++ G+D+ V + T L
Sbjct: 1268 VSLLLDRKANVEHRA-KTGLTPLME--AASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
AA GH + +L+ RG ++ R+ G +PL LA G H V+ LL +AGA + +
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
Score = 38.1 bits (87), Expect = 0.022
Identities = 19/48 (39%), Positives = 29/48 (60%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQ 455
AA+ G ++ +Q LV+ G+D+ D TPL AA R GH + V L++
Sbjct: 1360 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 34.3 bits (77), Expect = 0.32
Identities = 25/54 (46%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 401 VPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLL 454
V SLACA H VE L A G+D +G T L AA+GGHT V LL
Sbjct: 667 VLSLACAGGHLAVVELLLAH---GADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 6/187 (3%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL++ + E ++ + P +A AA+ G V+ ++ L+ +D+ G T L A
Sbjct: 286 LLAMHANVEDRGIKGDITPLMA--AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACA 343
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GG+ + V +LL+ G + + +G +PL+ A H V LL E GA ++T E +
Sbjct: 344 GGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKES 403
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
L Y+ LE ++ +AGAD + H+AL A G++ V L GAQ
Sbjct: 404 ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----SGAQ 459
Query: 564 APCPEPS 570
P S
Sbjct: 460 VNMPADS 466
Score = 66.2 bits (160), Expect = 8e-11
Identities = 46/149 (30%), Positives = 74/149 (49%), Gaps = 7/149 (4%)
Query: 381 VSWLLSLSGSQE--ADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPL 438
V +LL QE D + AL+ AC H VE + L++ G+ + + + ++PL
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALME--ACMDGH---VEVARLLLDSGAQVNMPADSFESPL 471
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQEL 498
AA GGH E +L++RG + + +G++PL+ A R H ++ LL GA+++ Q
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531
Query: 499 EEAGTELCRLAYRADLEGLQVWWQAGADL 527
E T L LE +AGAD+
Sbjct: 532 ETQETALTLACCGGFLEVADFLIKAGADI 560
Score = 63.2 bits (152), Expect = 6e-10
Identities = 37/121 (30%), Positives = 56/121 (46%)
Query: 433 NGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGAS 492
N T L A GGH E V LL+RG + RD GF+PL+LA H GV+ +L + GA
Sbjct: 831 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 890
Query: 493 LSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAF 552
+ Q T L E +++ GA+ ++ L +A + G + ++
Sbjct: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
Query: 553 L 553
L
Sbjct: 951 L 951
Score = 60.1 bits (144), Expect = 5e-09
Identities = 49/152 (32%), Positives = 72/152 (47%), Gaps = 8/152 (5%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+LAC G +E L++ G+D ++ TPL AA+ GH E V LL G +V+
Sbjct: 539 TLACCG---GFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQ 522
G + L A H V +L +AGA L E E T L + A + +Q
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLE-HESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 523 AGADLGQ-PGYDGHSALHVAEAAGNLAVVAFL 553
GA++ + + H+ L +A A G+LAVV L
Sbjct: 652 KGANVNRTTANNDHTVLSLACAGGHLAVVELL 683
Score = 59.3 bits (142), Expect = 9e-09
Identities = 64/211 (30%), Positives = 91/211 (43%), Gaps = 44/211 (20%)
Query: 381 VSWLLSLSGSQ---EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTP 437
V+ LL SG+Q AD+ + L AA G VE L+E G+ L V+ G TP
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLT-----LAACGGHVELAALLIERGASLEEVNDEGYTP 503
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTD------------GF----------------- 468
L AAR GH E V +LL +G ++N + + GF
Sbjct: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG 563
Query: 469 --SPLLLAVRGRHPGVIGLLREAGASL--STQELEEAGTELCRLAYRADLEGLQVWWQAG 524
+PL+ A + H ++ L AGA++ +T + A T C + + V QAG
Sbjct: 564 CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT---DVADVLLQAG 620
Query: 525 ADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
ADL G + L A AG++ V FL S
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Score = 59.3 bits (142), Expect = 9e-09
Identities = 41/146 (28%), Positives = 64/146 (43%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G +E ++ L+ G+++ G T L A GHT+ +LLQ G D+ G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL+ A R H + L GA+++ T L L +++ GAD
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L A G+ +VV +L
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYL 716
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/168 (31%), Positives = 76/168 (45%), Gaps = 15/168 (8%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDV-- 460
+LACA H E +Q L+E G+ + D G TPL AA GH V +LL G D+
Sbjct: 837 TLACAGGHE---ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 461 ---NTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGL 517
T+DT PL LA G V+ LL GA+ + + + T L A + +
Sbjct: 894 QSERTKDT----PLSLACSGGRQEVVELLLARGANKEHRNVSDY-TPLSLAASGGYVNII 948
Query: 518 QVWWQAGADLGQPGYD--GHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
++ AGA++ G S L +A G+ A V L + + AQ
Sbjct: 949 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 996
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/149 (29%), Positives = 75/149 (50%), Gaps = 3/149 (2%)
Query: 408 AAHAGDVEALQALVELGSDL-GLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA AG V ++ L++ G+D+ + TPL A GG E V +LL RG + R+
Sbjct: 872 AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 931
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWWQAGA 525
++PL LA G + +I +L AGA ++++ + G + L A +++ G+
Sbjct: 932 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 991
Query: 526 DL-GQPGYDGHSALHVAEAAGNLAVVAFL 553
D+ Q + ++AL +A G VV+ L
Sbjct: 992 DINAQIETNRNTALTLACFQGRTEVVSLL 1020
Score = 54.3 bits (129), Expect = 3e-07
Identities = 43/148 (29%), Positives = 72/148 (48%), Gaps = 2/148 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGL-VDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA G A++ L+++GSD+ ++ N T L A G TE V++LL R +V R
Sbjct: 974 AAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKT 1033
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEA-GTELCRLAYRADLEGLQVWWQAGA 525
G +PL+ A G + V +L + GA ++ + + T L A + + ++ GA
Sbjct: 1034 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1093
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ G++ L +A G+L VV L
Sbjct: 1094 HIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/79 (35%), Positives = 42/79 (53%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + + L+ G+ + + + G TPL AA GGH + V +L+Q G DV+ D
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Query: 468 FSPLLLAVRGRHPGVIGLL 486
+PL+ A R H V+ L
Sbjct: 1136 ITPLMAAFRKGHVKVVRYL 1154
Score = 50.4 bits (119), Expect = 4e-06
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 5/119 (4%)
Query: 381 VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGL--VDFNGQTPL 438
VS LL + E A + L P + AA G E + L++ G+D+ V + T L
Sbjct: 1017 VSLLLDRKANVEHRA-KTGLTPLME--AASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
AA GH + +L+ RG ++ R+ G +PL LA G H V+ LL +AGA + +
Sbjct: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132
Score = 38.1 bits (87), Expect = 0.022
Identities = 19/48 (39%), Positives = 29/48 (60%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQ 455
AA+ G ++ +Q LV+ G+D+ D TPL AA R GH + V L++
Sbjct: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 34.3 bits (77), Expect = 0.32
Identities = 25/54 (46%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 401 VPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLL 454
V SLACA H VE L A G+D +G T L AA+GGHT V LL
Sbjct: 667 VLSLACAGGHLAVVELLLAH---GADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 70.1 bits (170), Expect = 5e-12
Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 6/156 (3%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AAA G +E + L+ G+ + + G PL AAR GH + V +LL+RG DVN D
Sbjct: 1077 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1136
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELE--EAGTELCRLAYRADLEGLQVWWQAG 524
G +PL++A H + L GA+LS+ + E A + C +RA ++ L + G
Sbjct: 1137 GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV---EEG 1193
Query: 525 ADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
A + Q +G + L +A G+ V +L +GAV
Sbjct: 1194 AAIDQTDKNGRTPLDLAAFYGDAETVLYLVE-KGAV 1228
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/174 (30%), Positives = 77/174 (44%), Gaps = 12/174 (6%)
Query: 391 QEADALRNALVPSLACAAAHAGDVEALQALVELGSDL-----GLVDFNGQTPLHAAARGG 445
+++ AL+ AL AAA G +Q L+ + + G G+T L AAA G
Sbjct: 1028 RKSHALQQALT-----AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
Query: 446 HTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTEL 505
E +LL G V+ + G PL A R H ++ LL E G ++ + ++ T L
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD-KQGRTPL 1141
Query: 506 CRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
A L ++ GA L +G SAL A G+ AVV +L EGA
Sbjct: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE-EGA 1194
Score = 50.1 bits (118), Expect = 6e-06
Identities = 38/113 (33%), Positives = 51/113 (45%), Gaps = 3/113 (2%)
Query: 381 VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHA 440
V +LLS + + S AC H V Q LVE G+ + D NG+TPL
Sbjct: 1153 VEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV---QYLVEEGAAIDQTDKNGRTPLDL 1209
Query: 441 AARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASL 493
AA G E V L+++G + D G PL A+ R+ V+ L GA L
Sbjct: 1210 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
Score = 48.5 bits (114), Expect = 2e-05
Identities = 52/195 (26%), Positives = 82/195 (42%), Gaps = 19/195 (9%)
Query: 381 VSWLLSLSGSQ---EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTP 437
VS LL L G+ + L NA + C +H G E + L+E G+ L NG T
Sbjct: 907 VSRLLILGGANVNYRTEVLNNA---PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL---------RE 488
L AA GH + V +L ++GV V+ D G L+ + H ++ L +
Sbjct: 964 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
Query: 489 AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYD---GHSALHVAEAAG 545
G + L++A T + + + ++ L + + ++ G D G +AL A G
Sbjct: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCL-LGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
Query: 546 NLAVVAFLQSLEGAV 560
L V L AV
Sbjct: 1083 KLEVCELLLGHGAAV 1097
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 70.1 bits (170), Expect = 5e-12
Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 6/156 (3%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AAA G +E + L+ G+ + + G PL AAR GH + V +LL+RG DVN D
Sbjct: 1085 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1144
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELE--EAGTELCRLAYRADLEGLQVWWQAG 524
G +PL++A H + L GA+LS+ + E A + C +RA ++ L + G
Sbjct: 1145 GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV---EEG 1201
Query: 525 ADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
A + Q +G + L +A G+ V +L +GAV
Sbjct: 1202 AAIDQTDKNGRTPLDLAAFYGDAETVLYLVE-KGAV 1236
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/174 (30%), Positives = 77/174 (44%), Gaps = 12/174 (6%)
Query: 391 QEADALRNALVPSLACAAAHAGDVEALQALVELGSDL-----GLVDFNGQTPLHAAARGG 445
+++ AL+ AL AAA G +Q L+ + + G G+T L AAA G
Sbjct: 1036 RKSHALQQALT-----AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Query: 446 HTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTEL 505
E +LL G V+ + G PL A R H ++ LL E G ++ + ++ T L
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD-KQGRTPL 1149
Query: 506 CRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
A L ++ GA L +G SAL A G+ AVV +L EGA
Sbjct: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE-EGA 1202
Score = 50.1 bits (118), Expect = 6e-06
Identities = 38/113 (33%), Positives = 51/113 (45%), Gaps = 3/113 (2%)
Query: 381 VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHA 440
V +LLS + + S AC H V Q LVE G+ + D NG+TPL
Sbjct: 1161 VEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV---QYLVEEGAAIDQTDKNGRTPLDL 1217
Query: 441 AARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASL 493
AA G E V L+++G + D G PL A+ R+ V+ L GA L
Sbjct: 1218 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
Score = 48.5 bits (114), Expect = 2e-05
Identities = 52/195 (26%), Positives = 82/195 (42%), Gaps = 19/195 (9%)
Query: 381 VSWLLSLSGSQ---EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTP 437
VS LL L G+ + L NA + C +H G E + L+E G+ L NG T
Sbjct: 915 VSRLLILGGANVNYRTEVLNNA---PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL---------RE 488
L AA GH + V +L ++GV V+ D G L+ + H ++ L +
Sbjct: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
Query: 489 AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYD---GHSALHVAEAAG 545
G + L++A T + + + ++ L + + ++ G D G +AL A G
Sbjct: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCL-LGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Query: 546 NLAVVAFLQSLEGAV 560
L V L AV
Sbjct: 1091 KLEVCELLLGHGAAV 1105
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 70.1 bits (170), Expect = 5e-12
Identities = 51/146 (34%), Positives = 69/146 (47%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA +G E ++ LV+ G+ + + QTPLH +AR G + V LLQ+G N T G
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
++PL L+ R H V L + GASLS ++ T L A LE + Q A
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSI-TTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G G + LHVA N V L
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLL 617
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/153 (29%), Positives = 68/153 (44%), Gaps = 5/153 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ AG E ++ LV G+++ NG TPL+ AA+ H E V LL G + DG
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
F+PL +A++ H V+ LL E + L A + D + + Q +
Sbjct: 174 FTPLAVALQQGHDQVVSLLLENDTKGKVRL-----PALHIAARKDDTKAAALLLQNDNNA 228
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
G + LH+A GN+ V L + AV
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAV 261
Score = 60.5 bits (145), Expect = 4e-09
Identities = 43/158 (27%), Positives = 72/158 (45%), Gaps = 3/158 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G++ L+ + + N TPLH A++ G+ V +LL RG ++ + DG
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL R H V+ +L + A + ++ + G +A + D L +Q+ Q
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSK--TKNGLSPLHMATQGDHLNCVQLLLQHNVP 359
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
+ D +ALHVA G+ V L + A+A
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397
Score = 59.7 bits (143), Expect = 7e-09
Identities = 55/183 (30%), Positives = 83/183 (45%), Gaps = 10/183 (5%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL S S +A A ++ L P AAH + + L++ G+ NG TPLH AA+
Sbjct: 584 LLQKSASPDA-AGKSGLTP--LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL--REAGASLSTQELEEA 501
+ T LL+ G D N G + + LA + H ++ LL R A +LS ++
Sbjct: 641 KNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLS----NKS 696
Query: 502 GTELCRLAYRAD-LEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
G LA + D + +V GA + G++ LHV GN+ +V FL V
Sbjct: 697 GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
Query: 561 GAQ 563
A+
Sbjct: 757 NAK 759
Score = 59.3 bits (142), Expect = 9e-09
Identities = 46/170 (27%), Positives = 76/170 (44%), Gaps = 4/170 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + A AL +AC ++ ++ L++ G+ + V +G TP+H AA
Sbjct: 386 LLDKKANPNAKALNGFTPLHIACKKNR---IKVMELLLKHGASIQAVTESGLTPIHVAAF 442
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V+ L+ G NT + G + L +A R V+ L + GA + + ++ T
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ-T 501
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
L A + +Q Q GA G++ LH++ G+ V AFL
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/146 (30%), Positives = 69/146 (47%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG +E ++ G D+ + + NG LH A++ GH E V+ LLQR +V+ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L +A V+ +L GA+++ Q + T L A LE ++ GA
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQS-QNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L VA G+ VV+ L
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLL 192
Score = 57.0 bits (136), Expect = 5e-08
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 3/157 (1%)
Query: 397 RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQR 456
RN + P A+ G+ ++ L++ G+ + +G TPLH AR GH + V MLL R
Sbjct: 266 RNDITP--LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Query: 457 GVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEG 516
+ ++ +G SPL +A +G H + LL + + + T L A+ +
Sbjct: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD-DVTNDYLTALHVAAHCGHYKV 382
Query: 517 LQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+V A+ +G + LH+A + V+ L
Sbjct: 383 AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
Score = 56.6 bits (135), Expect = 6e-08
Identities = 46/173 (26%), Positives = 77/173 (44%), Gaps = 3/173 (1%)
Query: 381 VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHA 440
V+ LL G+ A +N P A + D+ L+E G+D V G +H
Sbjct: 613 VALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT--TLLEYGADANAVTRQGIASVHL 670
Query: 441 AARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEE 500
AA+ GH + V++LL R +VN + G +PL LA + V +L GA + Q +
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ-TKM 729
Query: 501 AGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
T L + +++ + Q A + +G++ LH A G+ ++ L
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 1/143 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH G + + L++ ++ NG TPLH A + + + +LL+ G + G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+P+ +A H ++ L GAS +T + T L A E ++ Q GA +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNV-RGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 528 GQPGYDGHSALHVAEAAGNLAVV 550
D + LH++ G +V
Sbjct: 493 EAKAKDDQTPLHISARLGKADIV 515
Score = 54.3 bits (129), Expect = 3e-07
Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 3/147 (2%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G V + L+ G+ + G+T LH AAR G E V L+Q G V + D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVW-WQAGAD 526
+PL ++ R ++ L + GA S +G L+ R E + + GA
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGA--SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
L G + LHVA G L V L
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 53.9 bits (128), Expect = 4e-07
Identities = 44/158 (27%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A + +Q L++ + V + T LH AA GH + +LL + + N + +G
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWWQAGAD 526
F+PL +A + V+ LL + GAS+ Q + E+G T + A+ + + GA
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASI--QAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
G +ALH+A +G VV +L V A+A
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496
Score = 52.4 bits (124), Expect = 1e-06
Identities = 39/146 (26%), Positives = 66/146 (45%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
+A G + L++ G+ L + G TPLH AA+ G E +LLQ+ + G
Sbjct: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSG 598
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A + V LL + GAS + T L A + ++ + GAD
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGAS-PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G +++H+A G++ +V+ L
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/85 (31%), Positives = 40/85 (47%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA V + LV G+ + G TPLH G+ + V LLQ VN + +G
Sbjct: 704 AAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNG 763
Query: 468 FSPLLLAVRGRHPGVIGLLREAGAS 492
++PL A + H +I +L + AS
Sbjct: 764 YTPLHQAAQQGHTHIINVLLQNNAS 788
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/162 (25%), Positives = 72/162 (44%), Gaps = 2/162 (1%)
Query: 392 EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVT 451
E D +P+L AA D +A L++ ++ + +G TPLH AA G+ T
Sbjct: 194 ENDTKGKVRLPALHIAA-RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 452 MLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYR 511
+LL R V+ + +PL +A + + ++ LL + GA + + + T L A
Sbjct: 253 LLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA-KTRDGLTPLHCGARS 311
Query: 512 ADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ +++ A + +G S LH+A +L V L
Sbjct: 312 GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353
Score = 45.1 bits (105), Expect = 2e-04
Identities = 24/78 (30%), Positives = 41/78 (52%)
Query: 410 HAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFS 469
H G+++ + L++ + + NG TPLH AA+ GHT + +LLQ N +G +
Sbjct: 739 HYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 798
Query: 470 PLLLAVRGRHPGVIGLLR 487
L +A R + V+ L+
Sbjct: 799 ALGIARRLGYISVVDTLK 816
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 69.3 bits (168), Expect = 9e-12
Identities = 53/180 (29%), Positives = 81/180 (45%), Gaps = 8/180 (4%)
Query: 381 VSWLLSLSGSQEADALRNALVP-------SLACAAAHAGDVEALQALVELGSDLGLVDFN 433
VS+LL L E + R + + AAA G +E + L+E G+ + +
Sbjct: 1007 VSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRR 1066
Query: 434 GQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASL 493
G PL + R GH + V +LL G DVN D G +PL++A H G + L GAS+
Sbjct: 1067 GAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASI 1126
Query: 494 STQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ + +E T L + L ++ GA +G + L +A G+ VV FL
Sbjct: 1127 ALMD-KEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1185
Score = 47.4 bits (111), Expect = 4e-05
Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 3/115 (2%)
Query: 379 GGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPL 438
G V +LL+ S S AC H + +++LV+ G+ D NG+TPL
Sbjct: 1114 GTVDFLLAQGASIALMDKEGLTALSWACLKGH---LSVVRSLVDNGAATDHADKNGRTPL 1170
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASL 493
AA G E V L+ G + D G PL AV R+ V+ L + GA +
Sbjct: 1171 DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1225
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 381 VSWLLSLSGSQ---EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTP 437
VS LL L G+ + L NA + C +H G E + L+E G+++ +G TP
Sbjct: 865 VSRLLILGGANINYRTEVLNNA---PILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
L AA G+ V +L ++ V+ D +G L+ A H V+ L + +++ Q+
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
Score = 38.9 bits (89), Expect = 0.013
Identities = 28/90 (31%), Positives = 41/90 (45%), Gaps = 3/90 (3%)
Query: 404 LACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTR 463
+A + H G V+ L A G+ + L+D G T L A GH V L+ G +
Sbjct: 1106 MAASEGHLGTVDFLLAQ---GASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHA 1162
Query: 464 DTDGFSPLLLAVRGRHPGVIGLLREAGASL 493
D +G +PL LA V+ L + GA +
Sbjct: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMI 1192
Score = 33.9 bits (76), Expect = 0.42
Identities = 45/168 (26%), Positives = 69/168 (41%), Gaps = 21/168 (12%)
Query: 406 CAAAHA---GDVEALQALVEL-----GSDLGLVDFNG--QTPLHAAARGGHTEAVTMLLQ 455
CA HA G +E ++ L++ G G+ + Q L AAA G+TE V+ LL
Sbjct: 953 CALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD 1012
Query: 456 ---------RGVDVNTRDTDGFSPLLLAVRGRHP-GVIGLLREAGASLSTQELEEAGTEL 505
+N+ D+ L A GR V LL E GA+++ Q L
Sbjct: 1013 LPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVA-QPNRRGAVPL 1071
Query: 506 CRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ + + + GAD+ G + L +A + G+L V FL
Sbjct: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFL 1119
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 13/223 (5%)
Query: 343 LSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVP 402
L LD ++ TK + E+TP R ++ +S +L G+ +N L P
Sbjct: 290 LLLDRGAQIETKT-KDELTPLHCAARNGHVR-------ISEILLDHGAPIQAKTKNGLSP 341
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
AA ++ ++ L++ +++ + + TPLH AA GH +LL +G N+
Sbjct: 342 --IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWW 521
R +GF+PL +A + H V+ LL + GAS+ + E+G T L ++ L ++
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA--VTESGLTPLHVASFMGHLPIVKNLL 457
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
Q GA + LH+A AG+ V +L + V A+A
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Score = 64.3 bits (155), Expect = 3e-10
Identities = 45/147 (30%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH ++ Q L+ G+ + NG TPLH A+R G+ V +LL RG + T+ D
Sbjct: 246 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H + +L + GA + Q + G +A + D L+ +++ Q A+
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPI--QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 363
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ D + LHVA G+ V L
Sbjct: 364 IDDITLDHLTPLHVAAHCGHHRVAKVL 390
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 397 RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQR 456
+N L P A H +++ ++ L+ G +NG TPLH AA+ E LLQ
Sbjct: 600 KNGLTP--LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657
Query: 457 GVDVNTRDTDGFSPLLLAVRGRHPGVIGLL--REAGASLSTQELEEAGTELCRLAYRADL 514
G N G +PL LA + H ++ LL ++A +L + T L +A +
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 714
Query: 515 EGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
V + G + G++ LHVA GN+ +V FL + V A+
Sbjct: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 763
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/174 (28%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG E ++ LV G+++ G TPL+ AA+ H E V LL+ G + N DG
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177
Query: 468 FSPLLLAVRGRHPGVIGLLREAG---------------------ASLSTQE------LEE 500
F+PL +A++ H V+ L G A++ Q L +
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 501 AG-TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G T L A+ +L Q+ GA + +G + LH+A GN+ +V L
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/168 (29%), Positives = 71/168 (42%), Gaps = 9/168 (5%)
Query: 396 LRNALVPSLACAAAHA--------GDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHT 447
L N P+LA A H G VE + AL+E + + G TPLH AA+ G
Sbjct: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
Query: 448 EAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCR 507
+LL+R N +G +PL +AV + ++ LL G S + T L
Sbjct: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW-NGYTPLHI 641
Query: 508 LAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
A + +E + Q G G + LH+A G+ +VA L S
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 1/157 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G ++ L+E ++ L G TPLH AAR GH E V LL++ G
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
F+PL +A + V LL E A + + T L + +L+ +++ G
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
P ++G++ LH+A + V L G+ A++
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 665
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA VE ++L++ G G TPLH AA+ GH E V +LL + + N + G
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL L + H V +L + G + T L ++ +++ ++ Q AD+
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G+S LH A G+ +V L
Sbjct: 761 NAKTKLGYSPLHQAAQQGHTDIVTLL 786
Score = 57.4 bits (137), Expect = 4e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 4/176 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + AL +AC H V ++ L++ G+ + V +G TPLH A+
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 446
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V LLQRG N + +PL +A R H V L + A ++ + ++ T
Sbjct: 447 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-T 505
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
L A +++ + A+ GH+ LH+A G++ V L E +
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 5/148 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + ++ L++ G+ + + +TPLH AAR GHTE LLQ VN + D
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503
Query: 468 FSPLLLAVRGRHPGVIGLLRE--AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGA 525
+PL A R H ++ LL E A +L+T T L A +E + + A
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPLHIAAREGHVETVLALLEKEA 560
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LHVA G + V L
Sbjct: 561 SQACMTKKGFTPLHVAAKYGKVRVAELL 588
Score = 55.1 bits (131), Expect = 2e-07
Identities = 28/80 (35%), Positives = 49/80 (61%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+H G+++ ++ L++ +D+ G +PLH AA+ GHT+ VT+LL+ G N +DG
Sbjct: 741 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800
Query: 468 FSPLLLAVRGRHPGVIGLLR 487
+PL +A R + V +L+
Sbjct: 801 TTPLAIAKRLGYISVTDVLK 820
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/103 (33%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 409 AHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGF 468
A G V L++ G + G TPLH A+ G+ + V LLQ DVN + G+
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 469 SPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYR 511
SPL A + H ++ LL + GA S E+ GT +A R
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGA--SPNEVSSDGTTPLAIAKR 809
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 1/153 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA D L++ + ++ G TPLH AA + +LL RG VN +G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A R + ++ LL + GA + T+ +E T L A + ++ GA +
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-TPLHCAARNGHVRISEILLDHGAPI 331
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+G S +H+A +L V L + +
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 364
Score = 50.1 bits (118), Expect = 6e-06
Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA +G+++ + G D+ + NG LH A++ GH + V LL + + + T G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L +A V+ L GA+++ Q ++ T L A LE ++ + GA+
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQ 170
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L VA G+ VVA L
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHL 196
Score = 37.7 bits (86), Expect = 0.029
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 1/116 (0%)
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
LH AAR T +LLQ + + GF+PL +A + V LL GAS++
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 498 LEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ T L + R ++ +++ GA + D + LH A G++ + L
Sbjct: 270 -QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 13/223 (5%)
Query: 343 LSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVP 402
L LD ++ TK + E+TP R ++ +S +L G+ +N L P
Sbjct: 257 LLLDRGAQIETKT-KDELTPLHCAARNGHVR-------ISEILLDHGAPIQAKTKNGLSP 308
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
AA ++ ++ L++ +++ + + TPLH AA GH +LL +G N+
Sbjct: 309 --IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWW 521
R +GF+PL +A + H V+ LL + GAS+ + E+G T L ++ L ++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA--VTESGLTPLHVASFMGHLPIVKNLL 424
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
Q GA + LH+A AG+ V +L + V A+A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 64.3 bits (155), Expect = 3e-10
Identities = 45/147 (30%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH ++ Q L+ G+ + NG TPLH A+R G+ V +LL RG + T+ D
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H + +L + GA + Q + G +A + D L+ +++ Q A+
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPI--QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ D + LHVA G+ V L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 397 RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQR 456
+N L P A H +++ ++ L+ G +NG TPLH AA+ E LLQ
Sbjct: 567 KNGLTP--LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 457 GVDVNTRDTDGFSPLLLAVRGRHPGVIGLL--REAGASLSTQELEEAGTELCRLAYRADL 514
G N G +PL LA + H ++ LL ++A +L + T L +A +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 515 EGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
V + G + G++ LHVA GN+ +V FL + V A+
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/174 (28%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG E ++ LV G+++ G TPL+ AA+ H E V LL+ G + N DG
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 468 FSPLLLAVRGRHPGVIGLLREAG---------------------ASLSTQE------LEE 500
F+PL +A++ H V+ L G A++ Q L +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 501 AG-TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G T L A+ +L Q+ GA + +G + LH+A GN+ +V L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/168 (29%), Positives = 71/168 (42%), Gaps = 9/168 (5%)
Query: 396 LRNALVPSLACAAAHA--------GDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHT 447
L N P+LA A H G VE + AL+E + + G TPLH AA+ G
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 448 EAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCR 507
+LL+R N +G +PL +AV + ++ LL G S + T L
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW-NGYTPLHI 608
Query: 508 LAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
A + +E + Q G G + LH+A G+ +VA L S
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 1/157 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G ++ L+E ++ L G TPLH AAR GH E V LL++ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
F+PL +A + V LL E A + + T L + +L+ +++ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
P ++G++ LH+A + V L G+ A++
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA VE ++L++ G G TPLH AA+ GH E V +LL + + N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL L + H V +L + G + T L ++ +++ ++ Q AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G+S LH A G+ +V L
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 57.4 bits (137), Expect = 4e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 4/176 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + AL +AC H V ++ L++ G+ + V +G TPLH A+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V LLQRG N + +PL +A R H V L + A ++ + ++ T
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-T 472
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
L A +++ + A+ GH+ LH+A G++ V L E +
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 5/148 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + ++ L++ G+ + + +TPLH AAR GHTE LLQ VN + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 468 FSPLLLAVRGRHPGVIGLLRE--AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGA 525
+PL A R H ++ LL E A +L+T T L A +E + + A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LHVA G + V L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 55.1 bits (131), Expect = 2e-07
Identities = 28/80 (35%), Positives = 49/80 (61%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+H G+++ ++ L++ +D+ G +PLH AA+ GHT+ VT+LL+ G N +DG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 468 FSPLLLAVRGRHPGVIGLLR 487
+PL +A R + V +L+
Sbjct: 768 TTPLAIAKRLGYISVTDVLK 787
Score = 52.8 bits (125), Expect = 9e-07
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 7/165 (4%)
Query: 389 GSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTE 448
G +EADA + L AA +G+++ + G D+ + NG LH A++ GH +
Sbjct: 6 GFREADAATSFL------RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 449 AVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRL 508
V LL + + + T G + L +A V+ L GA+++ Q ++ T L
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMA 118
Query: 509 AYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
A LE ++ + GA+ DG + L VA G+ VVA L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/103 (33%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 409 AHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGF 468
A G V L++ G + G TPLH A+ G+ + V LLQ DVN + G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 469 SPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYR 511
SPL A + H ++ LL + GA S E+ GT +A R
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA--SPNEVSSDGTTPLAIAKR 776
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 1/153 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA D L++ + ++ G TPLH AA + +LL RG VN +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A R + ++ LL + GA + T+ +E T L A + ++ GA +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-TPLHCAARNGHVRISEILLDHGAPI 298
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+G S +H+A +L V L + +
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 1/127 (0%)
Query: 427 LGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL 486
+G + + T AAR G+ + L+ GVD+NT + +G + L LA + H ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 487 REAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGN 546
L T ++ T L A E ++ GA++ G + L++A +
Sbjct: 65 LHKEIILET-TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 547 LAVVAFL 553
L VV FL
Sbjct: 124 LEVVKFL 130
Score = 37.7 bits (86), Expect = 0.029
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 1/116 (0%)
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
LH AAR T +LLQ + + GF+PL +A + V LL GAS++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 498 LEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ T L + R ++ +++ GA + D + LH A G++ + L
Sbjct: 237 -QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 13/223 (5%)
Query: 343 LSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVP 402
L LD ++ TK + E+TP R ++ +S +L G+ +N L P
Sbjct: 257 LLLDRGAQIETKT-KDELTPLHCAARNGHVR-------ISEILLDHGAPIQAKTKNGLSP 308
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
AA ++ ++ L++ +++ + + TPLH AA GH +LL +G N+
Sbjct: 309 --IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWW 521
R +GF+PL +A + H V+ LL + GAS+ + E+G T L ++ L ++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA--VTESGLTPLHVASFMGHLPIVKNLL 424
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
Q GA + LH+A AG+ V +L + V A+A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 64.3 bits (155), Expect = 3e-10
Identities = 45/147 (30%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH ++ Q L+ G+ + NG TPLH A+R G+ V +LL RG + T+ D
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H + +L + GA + Q + G +A + D L+ +++ Q A+
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPI--QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ D + LHVA G+ V L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 397 RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQR 456
+N L P A H +++ ++ L+ G +NG TPLH AA+ E LLQ
Sbjct: 567 KNGLTP--LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 457 GVDVNTRDTDGFSPLLLAVRGRHPGVIGLL--REAGASLSTQELEEAGTELCRLAYRADL 514
G N G +PL LA + H ++ LL ++A +L + T L +A +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 515 EGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
V + G + G++ LHVA GN+ +V FL + V A+
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/174 (28%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG E ++ LV G+++ G TPL+ AA+ H E V LL+ G + N DG
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 468 FSPLLLAVRGRHPGVIGLLREAG---------------------ASLSTQE------LEE 500
F+PL +A++ H V+ L G A++ Q L +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 501 AG-TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G T L A+ +L Q+ GA + +G + LH+A GN+ +V L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/168 (29%), Positives = 71/168 (42%), Gaps = 9/168 (5%)
Query: 396 LRNALVPSLACAAAHA--------GDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHT 447
L N P+LA A H G VE + AL+E + + G TPLH AA+ G
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 448 EAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCR 507
+LL+R N +G +PL +AV + ++ LL G S + T L
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW-NGYTPLHI 608
Query: 508 LAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
A + +E + Q G G + LH+A G+ +VA L S
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 1/157 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G ++ L+E ++ L G TPLH AAR GH E V LL++ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
F+PL +A + V LL E A + + T L + +L+ +++ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
P ++G++ LH+A + V L G+ A++
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA VE ++L++ G G TPLH AA+ GH E V +LL + + N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL L + H V +L + G + T L ++ +++ ++ Q AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G+S LH A G+ +V L
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 57.4 bits (137), Expect = 4e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 4/176 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + AL +AC H V ++ L++ G+ + V +G TPLH A+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V LLQRG N + +PL +A R H V L + A ++ + ++ T
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-T 472
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
L A +++ + A+ GH+ LH+A G++ V L E +
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 5/148 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + ++ L++ G+ + + +TPLH AAR GHTE LLQ VN + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 468 FSPLLLAVRGRHPGVIGLLRE--AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGA 525
+PL A R H ++ LL E A +L+T T L A +E + + A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LHVA G + V L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 55.1 bits (131), Expect = 2e-07
Identities = 28/80 (35%), Positives = 49/80 (61%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+H G+++ ++ L++ +D+ G +PLH AA+ GHT+ VT+LL+ G N +DG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 468 FSPLLLAVRGRHPGVIGLLR 487
+PL +A R + V +L+
Sbjct: 768 TTPLAIAKRLGYISVTDVLK 787
Score = 52.8 bits (125), Expect = 9e-07
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 7/165 (4%)
Query: 389 GSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTE 448
G +EADA + L AA +G+++ + G D+ + NG LH A++ GH +
Sbjct: 6 GFREADAATSFL------RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 449 AVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRL 508
V LL + + + T G + L +A V+ L GA+++ Q ++ T L
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMA 118
Query: 509 AYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
A LE ++ + GA+ DG + L VA G+ VVA L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/103 (33%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 409 AHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGF 468
A G V L++ G + G TPLH A+ G+ + V LLQ DVN + G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 469 SPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYR 511
SPL A + H ++ LL + GA S E+ GT +A R
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA--SPNEVSSDGTTPLAIAKR 776
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 1/153 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA D L++ + ++ G TPLH AA + +LL RG VN +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A R + ++ LL + GA + T+ +E T L A + ++ GA +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-TPLHCAARNGHVRISEILLDHGAPI 298
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+G S +H+A +L V L + +
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 1/127 (0%)
Query: 427 LGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL 486
+G + + T AAR G+ + L+ GVD+NT + +G + L LA + H ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 487 REAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGN 546
L T ++ T L A E ++ GA++ G + L++A +
Sbjct: 65 LHKEIILET-TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 547 LAVVAFL 553
L VV FL
Sbjct: 124 LEVVKFL 130
Score = 37.7 bits (86), Expect = 0.029
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 1/116 (0%)
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
LH AAR T +LLQ + + GF+PL +A + V LL GAS++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 498 LEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ T L + R ++ +++ GA + D + LH A G++ + L
Sbjct: 237 -QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 13/223 (5%)
Query: 343 LSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVP 402
L LD ++ TK + E+TP R ++ +S +L G+ +N L P
Sbjct: 257 LLLDRGAQIETKT-KDELTPLHCAARNGHVR-------ISEILLDHGAPIQAKTKNGLSP 308
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
AA ++ ++ L++ +++ + + TPLH AA GH +LL +G N+
Sbjct: 309 --IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWW 521
R +GF+PL +A + H V+ LL + GAS+ + E+G T L ++ L ++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA--VTESGLTPLHVASFMGHLPIVKNLL 424
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
Q GA + LH+A AG+ V +L + V A+A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 64.3 bits (155), Expect = 3e-10
Identities = 45/147 (30%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH ++ Q L+ G+ + NG TPLH A+R G+ V +LL RG + T+ D
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H + +L + GA + Q + G +A + D L+ +++ Q A+
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPI--QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ D + LHVA G+ V L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 397 RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQR 456
+N L P A H +++ ++ L+ G +NG TPLH AA+ E LLQ
Sbjct: 567 KNGLTP--LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 457 GVDVNTRDTDGFSPLLLAVRGRHPGVIGLL--REAGASLSTQELEEAGTELCRLAYRADL 514
G N G +PL LA + H ++ LL ++A +L + T L +A +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 515 EGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
V + G + G++ LHVA GN+ +V FL + V A+
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/174 (28%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG E ++ LV G+++ G TPL+ AA+ H E V LL+ G + N DG
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 468 FSPLLLAVRGRHPGVIGLLREAG---------------------ASLSTQE------LEE 500
F+PL +A++ H V+ L G A++ Q L +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 501 AG-TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G T L A+ +L Q+ GA + +G + LH+A GN+ +V L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/168 (29%), Positives = 71/168 (42%), Gaps = 9/168 (5%)
Query: 396 LRNALVPSLACAAAHA--------GDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHT 447
L N P+LA A H G VE + AL+E + + G TPLH AA+ G
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 448 EAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCR 507
+LL+R N +G +PL +AV + ++ LL G S + T L
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW-NGYTPLHI 608
Query: 508 LAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
A + +E + Q G G + LH+A G+ +VA L S
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 1/157 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G ++ L+E ++ L G TPLH AAR GH E V LL++ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
F+PL +A + V LL E A + + T L + +L+ +++ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
P ++G++ LH+A + V L G+ A++
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA VE ++L++ G G TPLH AA+ GH E V +LL + + N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL L + H V +L + G + T L ++ +++ ++ Q AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G+S LH A G+ +V L
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 57.4 bits (137), Expect = 4e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 4/176 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + AL +AC H V ++ L++ G+ + V +G TPLH A+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V LLQRG N + +PL +A R H V L + A ++ + ++ T
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-T 472
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
L A +++ + A+ GH+ LH+A G++ V L E +
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 5/148 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + ++ L++ G+ + + +TPLH AAR GHTE LLQ VN + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 468 FSPLLLAVRGRHPGVIGLLRE--AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGA 525
+PL A R H ++ LL E A +L+T T L A +E + + A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LHVA G + V L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 55.1 bits (131), Expect = 2e-07
Identities = 28/80 (35%), Positives = 49/80 (61%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+H G+++ ++ L++ +D+ G +PLH AA+ GHT+ VT+LL+ G N +DG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 468 FSPLLLAVRGRHPGVIGLLR 487
+PL +A R + V +L+
Sbjct: 768 TTPLAIAKRLGYISVTDVLK 787
Score = 52.8 bits (125), Expect = 9e-07
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 7/165 (4%)
Query: 389 GSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTE 448
G +EADA + L AA +G+++ + G D+ + NG LH A++ GH +
Sbjct: 6 GFREADAATSFL------RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 449 AVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRL 508
V LL + + + T G + L +A V+ L GA+++ Q ++ T L
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMA 118
Query: 509 AYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
A LE ++ + GA+ DG + L VA G+ VVA L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/103 (33%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 409 AHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGF 468
A G V L++ G + G TPLH A+ G+ + V LLQ DVN + G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 469 SPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYR 511
SPL A + H ++ LL + GA S E+ GT +A R
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA--SPNEVSSDGTTPLAIAKR 776
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 1/153 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA D L++ + ++ G TPLH AA + +LL RG VN +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A R + ++ LL + GA + T+ +E T L A + ++ GA +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-TPLHCAARNGHVRISEILLDHGAPI 298
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+G S +H+A +L V L + +
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 1/127 (0%)
Query: 427 LGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL 486
+G + + T AAR G+ + L+ GVD+NT + +G + L LA + H ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 487 REAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGN 546
L T ++ T L A E ++ GA++ G + L++A +
Sbjct: 65 LHKEIILET-TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 547 LAVVAFL 553
L VV FL
Sbjct: 124 LEVVKFL 130
Score = 37.7 bits (86), Expect = 0.029
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 1/116 (0%)
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
LH AAR T +LLQ + + GF+PL +A + V LL GAS++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 498 LEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ T L + R ++ +++ GA + D + LH A G++ + L
Sbjct: 237 -QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 13/223 (5%)
Query: 343 LSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVP 402
L LD ++ TK + E+TP R ++ +S +L G+ +N L P
Sbjct: 257 LLLDRGAQIETKT-KDELTPLHCAARNGHVR-------ISEILLDHGAPIQAKTKNGLSP 308
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
AA ++ ++ L++ +++ + + TPLH AA GH +LL +G N+
Sbjct: 309 --IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWW 521
R +GF+PL +A + H V+ LL + GAS+ + E+G T L ++ L ++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA--VTESGLTPLHVASFMGHLPIVKNLL 424
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
Q GA + LH+A AG+ V +L + V A+A
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 64.3 bits (155), Expect = 3e-10
Identities = 45/147 (30%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AAH ++ Q L+ G+ + NG TPLH A+R G+ V +LL RG + T+ D
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRAD-LEGLQVWWQAGAD 526
+PL A R H + +L + GA + Q + G +A + D L+ +++ Q A+
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPI--QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ D + LHVA G+ V L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 397 RNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQR 456
+N L P A H +++ ++ L+ G +NG TPLH AA+ E LLQ
Sbjct: 567 KNGLTP--LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 457 GVDVNTRDTDGFSPLLLAVRGRHPGVIGLL--REAGASLSTQELEEAGTELCRLAYRADL 514
G N G +PL LA + H ++ LL ++A +L + T L +A +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 515 EGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
V + G + G++ LHVA GN+ +V FL + V A+
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/174 (28%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA AG E ++ LV G+++ G TPL+ AA+ H E V LL+ G + N DG
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 468 FSPLLLAVRGRHPGVIGLLREAG---------------------ASLSTQE------LEE 500
F+PL +A++ H V+ L G A++ Q L +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 501 AG-TELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G T L A+ +L Q+ GA + +G + LH+A GN+ +V L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Score = 58.9 bits (141), Expect = 1e-08
Identities = 49/168 (29%), Positives = 71/168 (42%), Gaps = 9/168 (5%)
Query: 396 LRNALVPSLACAAAHA--------GDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHT 447
L N P+LA A H G VE + AL+E + + G TPLH AA+ G
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 448 EAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCR 507
+LL+R N +G +PL +AV + ++ LL G S + T L
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW-NGYTPLHI 608
Query: 508 LAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
A + +E + Q G G + LH+A G+ +VA L S
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 1/157 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G ++ L+E ++ L G TPLH AAR GH E V LL++ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
F+PL +A + V LL E A + + T L + +L+ +++ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQA 564
P ++G++ LH+A + V L G+ A++
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA VE ++L++ G G TPLH AA+ GH E V +LL + + N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL L + H V +L + G + T L ++ +++ ++ Q AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G+S LH A G+ +V L
Sbjct: 728 NAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 57.4 bits (137), Expect = 4e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 4/176 (2%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL + AL +AC H V ++ L++ G+ + V +G TPLH A+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GH V LLQRG N + +PL +A R H V L + A ++ + ++ T
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-T 472
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
L A +++ + A+ GH+ LH+A G++ V L E +
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 5/148 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + ++ L++ G+ + + +TPLH AAR GHTE LLQ VN + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 468 FSPLLLAVRGRHPGVIGLLRE--AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGA 525
+PL A R H ++ LL E A +L+T T L A +E + + A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFL 553
G + LHVA G + V L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 55.1 bits (131), Expect = 2e-07
Identities = 28/80 (35%), Positives = 49/80 (61%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+H G+++ ++ L++ +D+ G +PLH AA+ GHT+ VT+LL+ G N +DG
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 468 FSPLLLAVRGRHPGVIGLLR 487
+PL +A R + V +L+
Sbjct: 768 TTPLAIAKRLGYISVTDVLK 787
Score = 52.8 bits (125), Expect = 9e-07
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 7/165 (4%)
Query: 389 GSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTE 448
G +EADA + L AA +G+++ + G D+ + NG LH A++ GH +
Sbjct: 6 GFREADAATSFL------RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 449 AVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRL 508
V LL + + + T G + L +A V+ L GA+++ Q ++ T L
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMA 118
Query: 509 AYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
A LE ++ + GA+ DG + L VA G+ VVA L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/103 (33%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 409 AHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGF 468
A G V L++ G + G TPLH A+ G+ + V LLQ DVN + G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 469 SPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYR 511
SPL A + H ++ LL + GA S E+ GT +A R
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA--SPNEVSSDGTTPLAIAKR 776
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 1/153 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA D L++ + ++ G TPLH AA + +LL RG VN +G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A R + ++ LL + GA + T+ +E T L A + ++ GA +
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL-TPLHCAARNGHVRISEILLDHGAPI 298
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAV 560
+G S +H+A +L V L + +
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 1/127 (0%)
Query: 427 LGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL 486
+G + + T AAR G+ + L+ GVD+NT + +G + L LA + H ++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 487 REAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGN 546
L T ++ T L A E ++ GA++ G + L++A +
Sbjct: 65 LHKEIILET-TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 547 LAVVAFL 553
L VV FL
Sbjct: 124 LEVVKFL 130
Score = 37.7 bits (86), Expect = 0.029
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 1/116 (0%)
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
LH AAR T +LLQ + + GF+PL +A + V LL GAS++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 498 LEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ T L + R ++ +++ GA + D + LH A G++ + L
Sbjct: 237 -QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 66.6 bits (161), Expect = 6e-11
Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 34/180 (18%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRD-- 464
AAA+ GDV LQ L+ G+++ D TPLH AA + + + +LL DVN RD
Sbjct: 47 AAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKL 106
Query: 465 ----------------TDGFSPLLL---------------AVRGRHPGVIGLLREAGASL 493
+ +PLL AV H + LL GASL
Sbjct: 107 WQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL 166
Query: 494 STQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ + +E L A+ LE L++ GADLG G+ LH A A+G + VV +L
Sbjct: 167 NVCDKKER-QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYL 225
Score = 65.5 bits (158), Expect = 1e-10
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 2/165 (1%)
Query: 385 LSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARG 444
L L+ S + +A L AAA+ + +AL L S L + D +G++ LH A
Sbjct: 92 LLLAHSADVNARDKLWQTPLHVAAANRA-TKCAEALAPLLSSLNVADRSGRSALHHAVHS 150
Query: 445 GHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTE 504
GH E V +LL +G +N D PL A H V+ LL GA L ++ + G
Sbjct: 151 GHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGL- 209
Query: 505 LCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAV 549
L A +E ++ + GA++ +P G++ALH+A G AV
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
Score = 63.5 bits (153), Expect = 5e-10
Identities = 46/153 (30%), Positives = 70/153 (45%), Gaps = 3/153 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A H+G +E + L+ G+ L + D + PLH AA GH E + +L+ RG D+ +D G
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQV-WWQAGAD 526
+ L A V+ L GA + E G +A + + + AGA+
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEI--DEPNAFGNTALHIACYLGQDAVAIELVNAGAN 264
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
+ QP G + LHVA + N A+ L GA
Sbjct: 265 VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297
Score = 57.4 bits (137), Expect = 4e-08
Identities = 44/146 (30%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A + DVE +++L+ ++ ++D +TPLHAAA G + +LL G +VN +DT
Sbjct: 15 AIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLW 74
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL A R+ V+GLL A ++ ++ + T L A + + + L
Sbjct: 75 LTPLHRAAASRNEKVLGLLLAHSADVNARD-KLWQTPLHVAAANRATKCAEALAPLLSSL 133
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
G SALH A +G+L V L
Sbjct: 134 NVADRSGRSALHHAVHSGHLETVNLL 159
Score = 56.2 bits (134), Expect = 8e-08
Identities = 56/180 (31%), Positives = 76/180 (42%), Gaps = 19/180 (10%)
Query: 404 LACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTR 463
L AA H G Q L++ GS++ D G TPLH AAR GH ++ L+ G D R
Sbjct: 310 LHMAAIH-GRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
Query: 464 DTDGFSPLLLAVRGRHPGVIGLLREAG------ASLSTQELEEAG-----------TELC 506
PL LAV L +G +SLS + + AG T L
Sbjct: 369 GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLH 428
Query: 507 RLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPC 566
A ++E L + +GADL + G + LH A A G+ L + GA +A C
Sbjct: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT-AGAGVNEADC 487
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/140 (31%), Positives = 57/140 (40%), Gaps = 6/140 (4%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AAA G+VE L L+ G+DL D G+TPLH AA G + L+ G VN D
Sbjct: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK 488
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGAD 526
G SPL + R A + E L + L+ GAD
Sbjct: 489 GCSPL------HYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
Query: 527 LGQPGYDGHSALHVAEAAGN 546
G++A+H A A GN
Sbjct: 543 PSLRDRQGYTAVHYAAAYGN 562
Score = 55.1 bits (131), Expect = 2e-07
Identities = 44/150 (29%), Positives = 72/150 (48%), Gaps = 5/150 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQ-TPLHAAARGGHTEAVTMLLQRG--VDV-NTR 463
A G E ++ L G+ + + + TPLHAAA GHT+++ +L+ G D+ +
Sbjct: 625 ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM 684
Query: 464 DTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQA 523
D G +PL+LA+ H + LL E G++ +L T L R A + L
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL-RGRTALHRGAVTGCEDCLAALLDH 743
Query: 524 GADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
A + + G + +H+A A G+ AV+ L
Sbjct: 744 DAFVLCRDFKGRTPIHLASACGHTAVLRTL 773
Score = 52.0 bits (123), Expect = 1e-06
Identities = 45/169 (26%), Positives = 71/169 (42%), Gaps = 17/169 (10%)
Query: 404 LACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTR 463
L AA L+ LV G+D+ G++PLH AA G +L+Q G +++
Sbjct: 276 LHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA 335
Query: 464 DTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEE----------AGTELCR-LAYRA 512
D G +PL +A R H +I L GA + + + + ++ CR L
Sbjct: 336 DKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
Query: 513 DLEGL------QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
L + + AG D+ P G + LH A + GN+ + L S
Sbjct: 396 QLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLS 444
Score = 47.8 bits (112), Expect = 3e-05
Identities = 47/187 (25%), Positives = 72/187 (38%), Gaps = 41/187 (21%)
Query: 408 AAHAGDV----EALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTR 463
A H G V + L AL++ + + DF G+TP+H A+ GHT + LLQ + +
Sbjct: 724 ALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783
Query: 464 DT----DGFSPLLLAVRGRHPGVIGLLRE------------------------------- 488
D G+SP+ A H + LL E
Sbjct: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
Query: 489 --AGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGN 546
GA + + T L A+ ++ GL++ Q A++ + G +AL A G
Sbjct: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
Query: 547 LAVVAFL 553
A V FL
Sbjct: 904 TAAVEFL 910
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/163 (29%), Positives = 67/163 (41%), Gaps = 18/163 (11%)
Query: 404 LACAAAHAGDVEALQALVELGSDL-GLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
L CA + D L LG+ + D G+TPLHAAA + + MLLQ +VN
Sbjct: 827 LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA 886
Query: 463 RDTDGFSPLLLAV-RGRHPGVIGLLREAGASLSTQELEE---------AGTELCRLAYRA 512
D G + L+ A G+ V LL A L+ + + G E C L A
Sbjct: 887 TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILA 946
Query: 513 DLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
+ + L + + L P LH+A G +VV L S
Sbjct: 947 ETQDLGLINATNSALQMP-------LHIAARNGLASVVQALLS 982
Score = 43.9 bits (102), Expect = 4e-04
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 412 GDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPL 471
G V+ + L+E GS D G+T LH A G + + LL V RD G +P+
Sbjct: 699 GHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPI 758
Query: 472 LLAVRGRHPGVIGLLREAGASLSTQELE 499
LA H V+ L + A+LST L+
Sbjct: 759 HLASACGHTAVLRTLLQ--AALSTDPLD 784
Score = 41.2 bits (95), Expect = 0.003
Identities = 35/120 (29%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQ---TPLHAAARGGHTEAVTMLLQRGVDVNTRD 464
AA G+ + L+ L+E+ + L D +PLH AA GH EA+ L + V+++ RD
Sbjct: 557 AAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD 615
Query: 465 TDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAG 524
G + L LA + +L GAS +E + T L A + L + +G
Sbjct: 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/72 (40%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 404 LACAAAHAGDVEALQALVELGSDLGLVDFNG---QTPLHAAARGGHTEAVTMLLQRGVDV 460
LAC+ H + AL L E DLGL++ Q PLH AAR G V LL G V
Sbjct: 931 LACSKGH--EKCALMILAET-QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
Query: 461 NTRDTDGFSPLL 472
D +G +P L
Sbjct: 988 LAVDEEGHTPAL 999
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 66.2 bits (160), Expect = 8e-11
Identities = 45/147 (30%), Positives = 72/147 (48%), Gaps = 2/147 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA GD + + L+E + + VDF G+TP+H A + G V +LL+RGVDV+ + D
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDA 570
Query: 468 FSPLLLAVRGRHPGVIGLL-REAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGAD 526
+ PL A H ++ LL ++ G S++ Q L + T L A R ++ +D
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILIDLCSD 629
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFL 553
+ + LHVA G+ + L
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLL 656
Score = 60.1 bits (144), Expect = 5e-09
Identities = 61/223 (27%), Positives = 97/223 (43%), Gaps = 11/223 (4%)
Query: 343 LSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVP 402
LSL +E T DL + + ++ L + G S L+ + Q+ D ++
Sbjct: 387 LSLSFEREPSTSDLG------TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGA- 439
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
SL A AG E + L+ ++ L + G TPLH A V +LL R + VN
Sbjct: 440 SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNA 499
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGL-QVWW 521
+D D ++ L A + LL E AS++ E++ G +A + E + ++
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVN--EVDFEGRTPMHVACQHGQENIVRILL 557
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEG-AVGAQ 563
+ G D+ G D LH A G+L +V L G +V AQ
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600
Score = 59.7 bits (143), Expect = 7e-09
Identities = 32/86 (37%), Positives = 43/86 (50%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + L++L SD+ + QTPLH AA GHT +LL RG +DG
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASL 493
++ L LA R H + LL E A +
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADV 696
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/95 (35%), Positives = 48/95 (50%), Gaps = 1/95 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + ++ LVE +D+ QT LH AA GH+E V L+ V ++ D G
Sbjct: 677 AARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQG 735
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG 502
S L LA +GRH + L GA ++ Q L+ G
Sbjct: 736 LSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQG 770
Score = 47.4 bits (111), Expect = 4e-05
Identities = 43/151 (28%), Positives = 65/151 (43%), Gaps = 2/151 (1%)
Query: 408 AAHAGDVEALQALVEL-GSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA G + ++ L + G + +G+TPLH AA+ GH +L+ DVN
Sbjct: 577 AAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLL 636
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGAD 526
+PL +A H LL GA + T L A L +++ + AD
Sbjct: 637 AQTPLHVAAETGHTSTARLLLHRGAGKEAM-TSDGYTALHLAARNGHLATVKLLVEEKAD 695
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLE 557
+ G +ALH+A A G+ VV L S +
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELVSAD 726
Score = 37.7 bits (86), Expect = 0.029
Identities = 29/87 (33%), Positives = 41/87 (47%), Gaps = 10/87 (11%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+L AAAH G E ++ LV + L D G + LH AA+G H + V LL+ G +N
Sbjct: 706 ALHLAAAH-GHSEVVEELVS-ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREA 489
+ L +G H LLR +
Sbjct: 764 QS--------LKFQGGHGPAATLLRRS 782
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 66.2 bits (160), Expect = 8e-11
Identities = 52/167 (31%), Positives = 77/167 (46%), Gaps = 7/167 (4%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + L+ L++ + +VD +G T LH AA GG +L +N +D G
Sbjct: 122 AAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSG 181
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL++A + H + LL + GA+ + Q+L + T L A E ++V Q GA
Sbjct: 182 ATPLIIAAQMCHTDLCRLLLQQGAAANDQDL-QGRTALMLACEGASPETVEVLLQGGAQP 240
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPEPSCFQE 574
G G A H AG+ ++ LQ AQ P P PS E
Sbjct: 241 GITDALGQDAAHYGALAGDKLILHLLQE-----AAQRPSP-PSALTE 281
>gi|19924156 regulatory factor X-associated ankyrin-containing
protein isoform b [Homo sapiens]
Length = 237
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/89 (38%), Positives = 56/89 (62%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G++E ++ L+E G+D ++ ++ L A+ GG+T+ V +LL+R VD+N D +G
Sbjct: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQ 496
+PLL AVRG H + L GA L+T+
Sbjct: 168 GTPLLYAVRGNHVKCVEALLARGADLTTE 196
Score = 53.5 bits (127), Expect = 5e-07
Identities = 27/68 (39%), Positives = 39/68 (57%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + + L+E D+ + D+NG TPL A RG H + V LL RG D+ T G
Sbjct: 141 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
Query: 468 FSPLLLAV 475
++P+ LAV
Sbjct: 201 YTPMDLAV 208
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 1/133 (0%)
Query: 413 DVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLL 472
+V AL A ++ + + D G TPL A+ G E V LL+ G D + + S L
Sbjct: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALS 139
Query: 473 LAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGY 532
LA G + ++GLL E ++ + GT L ++ ++ GADL
Sbjct: 140 LASTGGYTDIVGLLLERDVDINIYDW-NGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
Query: 533 DGHSALHVAEAAG 545
G++ + +A A G
Sbjct: 199 SGYTPMDLAVALG 211
>gi|4506499 regulatory factor X-associated ankyrin-containing
protein isoform a [Homo sapiens]
Length = 260
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/89 (38%), Positives = 56/89 (62%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G++E ++ L+E G+D ++ ++ L A+ GG+T+ V +LL+R VD+N D +G
Sbjct: 131 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 190
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQ 496
+PLL AVRG H + L GA L+T+
Sbjct: 191 GTPLLYAVRGNHVKCVEALLARGADLTTE 219
Score = 53.5 bits (127), Expect = 5e-07
Identities = 27/68 (39%), Positives = 39/68 (57%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G + + L+E D+ + D+NG TPL A RG H + V LL RG D+ T G
Sbjct: 164 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 223
Query: 468 FSPLLLAV 475
++P+ LAV
Sbjct: 224 YTPMDLAV 231
Score = 44.7 bits (104), Expect = 2e-04
Identities = 49/191 (25%), Positives = 82/191 (42%), Gaps = 8/191 (4%)
Query: 361 TPPSVE-ERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHA----GDVE 415
TP V E S+ G + +L+ Q + + +AL +L + H G+++
Sbjct: 46 TPEPVNPEPDASVSSPQAGSSLKHSTTLTNRQRGNEV-SALPATLDSLSIHQLAAQGELD 104
Query: 416 ALQALVELGSDL-GLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLA 474
L+ + G +L D G TPL A+ G E V LL+ G D + + S L LA
Sbjct: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
Query: 475 VRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDG 534
G + ++GLL E ++ + GT L ++ ++ GADL G
Sbjct: 165 STGGYTDIVGLLLERDVDINIYDW-NGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 223
Query: 535 HSALHVAEAAG 545
++ + +A A G
Sbjct: 224 YTPMDLAVALG 234
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 65.5 bits (158), Expect = 1e-10
Identities = 42/124 (33%), Positives = 63/124 (50%), Gaps = 4/124 (3%)
Query: 405 ACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRD 464
AC H+ + + L+ G+ + D +TP+ A RGGH + LL +G VN RD
Sbjct: 151 ACLKGHS---QLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARD 207
Query: 465 TDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAG 524
G +PL +AVR RHP + L E GA L+ Q+ +E T L + +++ G
Sbjct: 208 KIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQD-KEGDTALHEAVRHGSYKAMKLLLLYG 266
Query: 525 ADLG 528
A+LG
Sbjct: 267 AELG 270
Score = 46.6 bits (109), Expect = 6e-05
Identities = 38/131 (29%), Positives = 60/131 (45%), Gaps = 3/131 (2%)
Query: 424 GSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVI 483
G D D +T LH A GH++ V LL G V+ RD +P+ A RG H ++
Sbjct: 134 GGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVIL 193
Query: 484 GLLREAGASLSTQELEEAGTELCRLAYRA-DLEGLQVWWQAGADLGQPGYDGHSALHVAE 542
L GA ++ + ++ G+ +A R + L+ + GA L +G +ALH A
Sbjct: 194 KQLLNQGARVNAR--DKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAV 251
Query: 543 AAGNLAVVAFL 553
G+ + L
Sbjct: 252 RHGSYKAMKLL 262
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/112 (30%), Positives = 50/112 (44%), Gaps = 1/112 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A G + L+ L+ G+ + D G TPLH A R H + + L++ G +N +D +G
Sbjct: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEE-AGTELCRLAYRADLEGLQ 518
+ L AVR + LL GA L + +L R R E LQ
Sbjct: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQ 295
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 65.1 bits (157), Expect = 2e-10
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 10/175 (5%)
Query: 381 VSWLLSLSGSQE--ADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPL 438
V +LL QE D + AL+ AC H VE + L++ G+ + + + ++PL
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALME--ACMDGH---VEVARLLLDSGAQVNMPADSFESPL 442
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQEL 498
AA GGH E +L++RG ++ + +G++PL+ A R H ++ LL GA+++ Q
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Query: 499 EEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
E T L E +AGAD+ + L A G+L +V +L
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYL 554
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 6/187 (3%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL++ + E + + P +A A+ G ++ ++ L+ +D+ G T L A
Sbjct: 257 LLAMHANVEDRGNKGDITPLMA--ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GG + V +LL G ++ + +G +PL+ A H V +L + GA ++T E +
Sbjct: 315 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
L Y+ L+ ++ +AGAD + H+AL A G++ V L GAQ
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----SGAQ 430
Query: 564 APCPEPS 570
P S
Sbjct: 431 VNMPADS 437
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/95 (33%), Positives = 45/95 (47%), Gaps = 6/95 (6%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+LAC G E L++ G+D ++ TPL A++ GH E V LL G +V+
Sbjct: 510 TLACCG---GFSEVADFLIKAGAD---IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
G + L A H V +L +AGA L QE
Sbjct: 564 TTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 65.1 bits (157), Expect = 2e-10
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 10/175 (5%)
Query: 381 VSWLLSLSGSQE--ADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPL 438
V +LL QE D + AL+ AC H VE + L++ G+ + + + ++PL
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALME--ACMDGH---VEVARLLLDSGAQVNMPADSFESPL 431
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQEL 498
AA GGH E +L++RG ++ + +G++PL+ A R H ++ LL GA+++ Q
Sbjct: 432 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 491
Query: 499 EEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
E T L E +AGAD+ + L A G+L +V +L
Sbjct: 492 ETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYL 543
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 6/187 (3%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL++ + E + + P +A A+ G ++ ++ L+ +D+ G T L A
Sbjct: 246 LLAMHANVEDRGNKGDITPLMA--ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 303
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GG + V +LL G ++ + +G +PL+ A H V +L + GA ++T E +
Sbjct: 304 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 363
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
L Y+ L+ ++ +AGAD + H+AL A G++ V L GAQ
Sbjct: 364 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----SGAQ 419
Query: 564 APCPEPS 570
P S
Sbjct: 420 VNMPADS 426
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/95 (33%), Positives = 45/95 (47%), Gaps = 6/95 (6%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+LAC G E L++ G+D ++ TPL A++ GH E V LL G +V+
Sbjct: 499 TLACCG---GFSEVADFLIKAGAD---IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
G + L A H V +L +AGA L QE
Sbjct: 553 TTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 65.1 bits (157), Expect = 2e-10
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 10/175 (5%)
Query: 381 VSWLLSLSGSQE--ADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPL 438
V +LL QE D + AL+ AC H VE + L++ G+ + + + ++PL
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALME--ACMDGH---VEVARLLLDSGAQVNMPADSFESPL 442
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQEL 498
AA GGH E +L++RG ++ + +G++PL+ A R H ++ LL GA+++ Q
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Query: 499 EEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
E T L E +AGAD+ + L A G+L +V +L
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYL 554
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 6/187 (3%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL++ + E + + P +A A+ G ++ ++ L+ +D+ G T L A
Sbjct: 257 LLAMHANVEDRGNKGDITPLMA--ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GG + V +LL G ++ + +G +PL+ A H V +L + GA ++T E +
Sbjct: 315 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
L Y+ L+ ++ +AGAD + H+AL A G++ V L GAQ
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----SGAQ 430
Query: 564 APCPEPS 570
P S
Sbjct: 431 VNMPADS 437
Score = 60.5 bits (145), Expect = 4e-09
Identities = 65/211 (30%), Positives = 92/211 (43%), Gaps = 44/211 (20%)
Query: 381 VSWLLSLSGSQ---EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTP 437
V+ LL SG+Q AD+ + L AA G VE L+E G++L V+ G TP
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLT-----LAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTD------------GFS---------------- 469
L AAR GH E V +LL +G ++N + + GFS
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
Query: 470 ---PLLLAVRGRHPGVIGLLREAGASL--STQELEEAGTELCRLAYRADLEGLQVWWQAG 524
PL+ A + H ++ L +GA++ +T + A T C + + V QAG
Sbjct: 535 CSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT---DVADVLLQAG 591
Query: 525 ADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
ADL G + L A AG+L V FL S
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
Score = 59.3 bits (142), Expect = 9e-09
Identities = 57/237 (24%), Positives = 99/237 (41%), Gaps = 9/237 (3%)
Query: 322 GFDMTSEAALAKLS---YVLGQPGLSLDVRKE-LLTKDLRGEMTPPSVEERRPSLQGNTL 377
G + T+ L K+S ++GQP +++ + LL ++ G M + +L + L
Sbjct: 942 GSNGTNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTL--DDL 999
Query: 378 GGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGL-VDFNGQT 436
VS + +GS + L P +C+ + V D+ + N T
Sbjct: 1000 IAAVSTRVP-TGSNSSSQTTECLTPE-SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT 1057
Query: 437 PLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQ 496
L A GGH E V++L+ R + RD GF+PL+LA H GV+ +L + G + Q
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 497 ELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
T L E + + GA+ ++ L +A + G + ++ L
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/149 (29%), Positives = 75/149 (50%), Gaps = 3/149 (2%)
Query: 408 AAHAGDVEALQALVELGSDL-GLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA AG V ++ L++ G D+ + TPL A GG E V +LL RG + R+
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWWQAGA 525
++PL LA G + +I +L AGA ++++ + G + L A + +++ G+
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
Query: 526 DL-GQPGYDGHSALHVAEAAGNLAVVAFL 553
D+ Q + ++AL +A G VV+ L
Sbjct: 1215 DINAQIETNRNTALTLACFQGRAEVVSLL 1243
Score = 57.8 bits (138), Expect = 3e-08
Identities = 48/152 (31%), Positives = 71/152 (46%), Gaps = 8/152 (5%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+LAC G E L++ G+D ++ TPL A++ GH E V LL G +V+
Sbjct: 510 TLACCG---GFSEVADFLIKAGAD---IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQ 522
G + L A H V +L +AGA L E E T L + A L +Q
Sbjct: 564 TTATGDTALTYACENGHTDVADVLLQAGADLE-HESEGGRTPLMKAARAGHLCTVQFLIS 622
Query: 523 AGADLGQ-PGYDGHSALHVAEAAGNLAVVAFL 553
GA++ + + H+ + +A A G+LAVV L
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHLAVVELL 654
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/146 (26%), Positives = 64/146 (43%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G +E ++ L+ G+++ G T L A GHT+ +LLQ G D+ G
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL+ A R H + L GA+++ T + L +++ GAD
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L A G+ VV++L
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/79 (34%), Positives = 42/79 (53%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + + L+ G+ + + + G TPL A+ GGH + V +L+Q G DV+ D
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 468 FSPLLLAVRGRHPGVIGLL 486
+PL+ A R H V+ L
Sbjct: 1359 ITPLMSAFRKGHVKVVQYL 1377
Score = 50.1 bits (118), Expect = 6e-06
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 5/119 (4%)
Query: 381 VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGL--VDFNGQTPL 438
VS LL + E A + L P + AA G E + L++ G+D+ V + T L
Sbjct: 1240 VSLLLDRKANVEHRA-KTGLTPLME--AASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
AA GH + +L+ RG ++ R+ G +PL LA G H V+ LL +AGA + +
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Score = 43.5 bits (101), Expect = 5e-04
Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 11/152 (7%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVN------ 461
A G E + L++ +++ G TPL AA GG+ E +LL +G DVN
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 462 TRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWW 521
+RDT L +A H LL GA + + ++ T L + + +Q+
Sbjct: 1291 SRDT----ALTIAADKGHYKFCELLIHRGAHIDVRN-KKGNTPLWLASNGGHFDVVQLLV 1345
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
QAGAD+ + L A G++ VV +L
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Score = 37.4 bits (85), Expect = 0.038
Identities = 34/92 (36%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 381 VSWLLSLSGS-QEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLH 439
V +L+S + A A + V SLACA H VE L A G+D +G T L
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH---GADPTHRLKDGSTMLI 673
Query: 440 AAARGGHTEAVTMLLQRGVDVNTRDTDGFSPL 471
AA+GGHT V+ LL +V + T S L
Sbjct: 674 EAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
Score = 35.0 bits (79), Expect = 0.19
Identities = 17/48 (35%), Positives = 28/48 (58%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQ 455
A++ G + +Q LV+ G+D+ D TPL +A R GH + V L++
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 65.1 bits (157), Expect = 2e-10
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 10/175 (5%)
Query: 381 VSWLLSLSGSQE--ADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPL 438
V +LL QE D + AL+ AC H VE + L++ G+ + + + ++PL
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALME--ACMDGH---VEVARLLLDSGAQVNMPADSFESPL 442
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQEL 498
AA GGH E +L++RG ++ + +G++PL+ A R H ++ LL GA+++ Q
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Query: 499 EEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
E T L E +AGAD+ + L A G+L +V +L
Sbjct: 503 ETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYL 554
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 6/187 (3%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL++ + E + + P +A A+ G ++ ++ L+ +D+ G T L A
Sbjct: 257 LLAMHANVEDRGNKGDITPLMA--ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GG + V +LL G ++ + +G +PL+ A H V +L + GA ++T E +
Sbjct: 315 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
Query: 504 ELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQ 563
L Y+ L+ ++ +AGAD + H+AL A G++ V L GAQ
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----SGAQ 430
Query: 564 APCPEPS 570
P S
Sbjct: 431 VNMPADS 437
Score = 60.5 bits (145), Expect = 4e-09
Identities = 65/211 (30%), Positives = 92/211 (43%), Gaps = 44/211 (20%)
Query: 381 VSWLLSLSGSQ---EADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTP 437
V+ LL SG+Q AD+ + L AA G VE L+E G++L V+ G TP
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLT-----LAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 438 LHAAARGGHTEAVTMLLQRGVDVNTRDTD------------GFS---------------- 469
L AAR GH E V +LL +G ++N + + GFS
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
Query: 470 ---PLLLAVRGRHPGVIGLLREAGASL--STQELEEAGTELCRLAYRADLEGLQVWWQAG 524
PL+ A + H ++ L +GA++ +T + A T C + + V QAG
Sbjct: 535 CSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT---DVADVLLQAG 591
Query: 525 ADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
ADL G + L A AG+L V FL S
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
Score = 59.3 bits (142), Expect = 9e-09
Identities = 57/237 (24%), Positives = 99/237 (41%), Gaps = 9/237 (3%)
Query: 322 GFDMTSEAALAKLS---YVLGQPGLSLDVRKE-LLTKDLRGEMTPPSVEERRPSLQGNTL 377
G + T+ L K+S ++GQP +++ + LL ++ G M + +L + L
Sbjct: 942 GSNGTNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTL--DDL 999
Query: 378 GGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGL-VDFNGQT 436
VS + +GS + L P +C+ + V D+ + N T
Sbjct: 1000 IAAVSTRVP-TGSNSSSQTTECLTPE-SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT 1057
Query: 437 PLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQ 496
L A GGH E V++L+ R + RD GF+PL+LA H GV+ +L + G + Q
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 497 ELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
T L E + + GA+ ++ L +A + G + ++ L
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/149 (29%), Positives = 75/149 (50%), Gaps = 3/149 (2%)
Query: 408 AAHAGDVEALQALVELGSDL-GLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AA AG V ++ L++ G D+ + TPL A GG E V +LL RG + R+
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAG-TELCRLAYRADLEGLQVWWQAGA 525
++PL LA G + +I +L AGA ++++ + G + L A + +++ G+
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
Query: 526 DL-GQPGYDGHSALHVAEAAGNLAVVAFL 553
D+ Q + ++AL +A G VV+ L
Sbjct: 1215 DINAQIETNRNTALTLACFQGRAEVVSLL 1243
Score = 57.8 bits (138), Expect = 3e-08
Identities = 48/152 (31%), Positives = 71/152 (46%), Gaps = 8/152 (5%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
+LAC G E L++ G+D ++ TPL A++ GH E V LL G +V+
Sbjct: 510 TLACCG---GFSEVADFLIKAGAD---IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQ 522
G + L A H V +L +AGA L E E T L + A L +Q
Sbjct: 564 TTATGDTALTYACENGHTDVADVLLQAGADLE-HESEGGRTPLMKAARAGHLCTVQFLIS 622
Query: 523 AGADLGQ-PGYDGHSALHVAEAAGNLAVVAFL 553
GA++ + + H+ + +A A G+LAVV L
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHLAVVELL 654
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/146 (26%), Positives = 64/146 (43%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A+ G +E ++ L+ G+++ G T L A GHT+ +LLQ G D+ G
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL+ A R H + L GA+++ T + L +++ GAD
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
DG + L A G+ VV++L
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/79 (34%), Positives = 42/79 (53%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + + L+ G+ + + + G TPL A+ GGH + V +L+Q G DV+ D
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 468 FSPLLLAVRGRHPGVIGLL 486
+PL+ A R H V+ L
Sbjct: 1359 ITPLMSAFRKGHVKVVQYL 1377
Score = 50.1 bits (118), Expect = 6e-06
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 5/119 (4%)
Query: 381 VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGL--VDFNGQTPL 438
VS LL + E A + L P + AA G E + L++ G+D+ V + T L
Sbjct: 1240 VSLLLDRKANVEHRA-KTGLTPLME--AASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
Query: 439 HAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
AA GH + +L+ RG ++ R+ G +PL LA G H V+ LL +AGA + +
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Score = 43.5 bits (101), Expect = 5e-04
Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 11/152 (7%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVN------ 461
A G E + L++ +++ G TPL AA GG+ E +LL +G DVN
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 462 TRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWW 521
+RDT L +A H LL GA + + ++ T L + + +Q+
Sbjct: 1291 SRDT----ALTIAADKGHYKFCELLIHRGAHIDVRN-KKGNTPLWLASNGGHFDVVQLLV 1345
Query: 522 QAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
QAGAD+ + L A G++ VV +L
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Score = 37.4 bits (85), Expect = 0.038
Identities = 34/92 (36%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 381 VSWLLSLSGS-QEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLH 439
V +L+S + A A + V SLACA H VE L A G+D +G T L
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH---GADPTHRLKDGSTMLI 673
Query: 440 AAARGGHTEAVTMLLQRGVDVNTRDTDGFSPL 471
AA+GGHT V+ LL +V + T S L
Sbjct: 674 EAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
Score = 35.0 bits (79), Expect = 0.19
Identities = 17/48 (35%), Positives = 28/48 (58%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQ 455
A++ G + +Q LV+ G+D+ D TPL +A R GH + V L++
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/158 (30%), Positives = 73/158 (46%), Gaps = 2/158 (1%)
Query: 398 NALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRG 457
N P L AAA L+ LV G+D+ + +G++PLH A G L+Q G
Sbjct: 246 NGFTP-LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNG 304
Query: 458 VDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGL 517
+++ D DG +PL +A R H +I LR +GA + + L A A +
Sbjct: 305 GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM-FPLHLAALNAHSDCC 363
Query: 518 QVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
+ +G ++ P G + LH A A GN+ + LQS
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401
Score = 60.1 bits (144), Expect = 5e-09
Identities = 42/150 (28%), Positives = 71/150 (47%), Gaps = 2/150 (1%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
AAA G + ++ L+ LG ++ ++ G T LH A G V L+ G +VN + +
Sbjct: 187 AAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
Query: 467 GFSPLLLAVRGRHPGV-IGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGA 525
GF+PL A H + + LL GA ++ Q ++ + L A Q Q G
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQS-KDGKSPLHMTAVHGRFTRSQTLIQNGG 305
Query: 526 DLGQPGYDGHSALHVAEAAGNLAVVAFLQS 555
++ DG++ LHVA G+ ++ L++
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRT 335
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/192 (28%), Positives = 90/192 (46%), Gaps = 4/192 (2%)
Query: 366 EERRPSLQGNTLGGG-VSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELG 424
E+R P LG + LL LSG++ +A N + L A A + EA+Q L++
Sbjct: 15 EKRTPLHVAAFLGDAEIIELLILSGAR-VNAKDNMWLTPLHRAVASRSE-EAVQVLIKHS 72
Query: 425 SDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIG 484
+D+ D N QTPLH AA + +++ VN D G + L A H ++
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 485 LLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAA 544
LL GA+++ + ++ L AY L+ + + GA++ G++ LH A +
Sbjct: 133 LLLAKGANINAFDKKDRRA-LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Query: 545 GNLAVVAFLQSL 556
G + VV L +L
Sbjct: 192 GQINVVKHLLNL 203
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/147 (29%), Positives = 72/147 (48%), Gaps = 2/147 (1%)
Query: 404 LACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTR 463
L AAA+ V+ + ++ L S + + D G+T LH AA GH E V +LL +G ++N
Sbjct: 86 LHVAAANKA-VKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAF 144
Query: 464 DTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQA 523
D L A H V+ LL GA ++ ++ ++ T L A + ++
Sbjct: 145 DKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD-KKGYTPLHAAASNGQINVVKHLLNL 203
Query: 524 GADLGQPGYDGHSALHVAEAAGNLAVV 550
G ++ + G++ALH+A G AVV
Sbjct: 204 GVEIDEINVYGNTALHIACYNGQDAVV 230
Score = 57.0 bits (136), Expect = 5e-08
Identities = 43/153 (28%), Positives = 68/153 (44%), Gaps = 3/153 (1%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G VE + L+ G+++ D + LH AA GH + V +L+ G +V +D G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLA-YRADLEGLQVWWQAGAD 526
++PL A V+ L G + E+ G +A Y + GA+
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEID--EINVYGNTALHIACYNGQDAVVNELIDYGAN 239
Query: 527 LGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGA 559
+ QP +G + LH A A+ + A+ L GA
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGA 272
Score = 54.3 bits (129), Expect = 3e-07
Identities = 45/161 (27%), Positives = 72/161 (44%), Gaps = 5/161 (3%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA GD E ++ L+ G+ + D TPLH A EAV +L++ DVN RD +
Sbjct: 23 AAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNW 82
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL +A + ++ +S++ + T L A +E + + GA++
Sbjct: 83 QTPLHVAAANKAVKCAEVIIPLLSSVNVSD-RGGRTALHHAALNGHVEMVNLLLAKGANI 141
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPE 568
ALH A G+L VVA L + GA+ C +
Sbjct: 142 NAFDKKDRRALHWAAYMGHLDVVALLIN----HGAEVTCKD 178
Score = 53.9 bits (128), Expect = 4e-07
Identities = 48/171 (28%), Positives = 80/171 (46%), Gaps = 12/171 (7%)
Query: 408 AAHAGDVEALQALVELGSDLGLVD-FNGQTPLHAAARGGHTEAVTMLLQRGVD---VNTR 463
AA G E ++AL+ G+ + + D +TPLHA+ GHT + +LL+ + V+ +
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641
Query: 464 DTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQA 523
D G +PL+LAV H + LL E A++ T ++ T L R E +Q+ +
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGC-TALHRGIMTGHEECVQMLLEQ 700
Query: 524 GADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPEPSCFQE 574
+ G + LH A A G+ ++ L + A E CF++
Sbjct: 701 EVSILCKDSRGRTPLHYAAARGHATWLSELLQM-------ALSEEDCCFKD 744
Score = 53.1 bits (126), Expect = 7e-07
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 6/141 (4%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA+ G ++ + L+ G+++ D G TPLHAAA G V LL GV+++ + G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEG---LQVWWQAG 524
+ L +A V+ L + GA+++ Q T L A A G L++ G
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAA--ASTHGALCLELLVNNG 271
Query: 525 ADLGQPGYDGHSALHVAEAAG 545
AD+ DG S LH+ G
Sbjct: 272 ADVNIQSKDGKSPLHMTAVHG 292
Score = 50.1 bits (118), Expect = 6e-06
Identities = 39/132 (29%), Positives = 64/132 (48%), Gaps = 6/132 (4%)
Query: 385 LSLSGSQEADALRNALVP-SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
L SG+ A +++ P LA AH+ + + L+ G ++ D G+T LHAAA
Sbjct: 333 LRTSGADTAKCGIHSMFPLHLAALNAHS---DCCRKLLSSGFEIDTPDKFGRTCLHAAAA 389
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGT 503
GG+ E + +L G D + +D G +PL A H I L GA+++ E ++ G
Sbjct: 390 GGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN--ETDDWGR 447
Query: 504 ELCRLAYRADLE 515
A +D++
Sbjct: 448 TALHYAAASDMD 459
Score = 49.7 bits (117), Expect = 7e-06
Identities = 34/107 (31%), Positives = 56/107 (52%), Gaps = 1/107 (0%)
Query: 384 LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAAR 443
LL ++ + EA +++A + A G ++A+ L+E +++ VD G T LH
Sbjct: 628 LLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIM 687
Query: 444 GGHTEAVTMLLQRGVDVNTRDTDGFSPL-LLAVRGRHPGVIGLLREA 489
GH E V MLL++ V + +D+ G +PL A RG + LL+ A
Sbjct: 688 TGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMA 734
Score = 47.0 bits (110), Expect = 5e-05
Identities = 37/137 (27%), Positives = 59/137 (43%), Gaps = 1/137 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + L G+D + PLH AA H++ LL G +++T D G
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFG 380
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L A G + I LL+ +GA ++ + T L A ++ GA++
Sbjct: 381 RTCLHAAAAGGNVECIKLLQSSGADFHKKD-KCGRTPLHYAAANCHFHCIETLVTTGANV 439
Query: 528 GQPGYDGHSALHVAEAA 544
+ G +ALH A A+
Sbjct: 440 NETDDWGRTALHYAAAS 456
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/134 (26%), Positives = 61/134 (45%), Gaps = 1/134 (0%)
Query: 420 LVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRH 479
L+ D+ +D +TPLH AA G E + +L+ G VN +D +PL AV R
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 480 PGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALH 539
+ +L + A ++ ++ + T L A ++ +V + + G +ALH
Sbjct: 62 EEAVQVLIKHSADVNARD-KNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 540 VAEAAGNLAVVAFL 553
A G++ +V L
Sbjct: 121 HAALNGHVEMVNLL 134
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/92 (34%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQT--PLHAAARGGHTEAVTMLLQRGVDVNTRDT 465
AA G + L+ L+E + +G T PLH AA GH +A+ +LLQ VD++ RD
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 466 DGFSPLLLAVRGRHPGVIGLLREAGASLSTQE 497
G + L LA H + L GAS+ ++
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 431 DFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLL-REA 489
D G+TPL AAA H E + +LL+ VN D G + L++A G + +L A
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 490 GASLSTQE 497
A L+ ++
Sbjct: 871 QADLTVKD 878
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/74 (37%), Positives = 38/74 (51%), Gaps = 1/74 (1%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRG-VDVNTRDT 465
AAA A VE LQ L+ + + VD +G+T L AA G AV +L+ D+ +D
Sbjct: 820 AAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDK 879
Query: 466 DGFSPLLLAVRGRH 479
D +PL LA H
Sbjct: 880 DLNTPLHLACSKGH 893
Score = 37.4 bits (85), Expect = 0.038
Identities = 39/150 (26%), Positives = 61/150 (40%), Gaps = 2/150 (1%)
Query: 405 ACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRD 464
A A HA + L + D D G TPLH A G+ + +LL++
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFI 776
Query: 465 TDGFSPLLLAVRGRHPGVIGLLREA-GASLSTQELEEAGTELCRLAYRADLEGLQVWWQA 523
+ F+PL A+ H LL A +S+ + ++ T L A+ +E LQ+ +
Sbjct: 777 GNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836
Query: 524 GADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
A + G +AL +A G V L
Sbjct: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
Score = 33.1 bits (74), Expect = 0.72
Identities = 28/113 (24%), Positives = 51/113 (45%), Gaps = 3/113 (2%)
Query: 417 LQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGF--SPLLLA 474
L+ L++ ++ + D G +H AA GH + + +LL+R G SPL LA
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Query: 475 VRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
H + +L ++ L ++ E+ T L A++ E ++ GA +
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRD-EKGRTALDLAAFKGHTECVEALINPGASI 601
Score = 32.3 bits (72), Expect = 1.2
Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 1/92 (1%)
Query: 452 MLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYR 511
ML+ + DVNT D++ +PL +A +I LL +GA ++ ++ T L R
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD-NMWLTPLHRAVAS 59
Query: 512 ADLEGLQVWWQAGADLGQPGYDGHSALHVAEA 543
E +QV + AD+ + + LHVA A
Sbjct: 60 RSEEAVQVLIKHSADVNARDKNWQTPLHVAAA 91
Score = 32.0 bits (71), Expect = 1.6
Identities = 54/217 (24%), Positives = 80/217 (36%), Gaps = 35/217 (16%)
Query: 369 RPSLQGNTLGGGVSW--LLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSD 426
R L GG V LL SG+ + P L AAA+ ++ LV G++
Sbjct: 381 RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP-LHYAAANC-HFHCIETLVTTGAN 438
Query: 427 LGLVDFNGQTPLHAAARGGH----------------------------TEAVTMLLQRGV 458
+ D G+T LH AA T + LLQ
Sbjct: 439 VNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDA 498
Query: 459 DVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTE--LCRLAYRADLEG 516
+ + RD +G++ + A H + LL E S +E + T+ L AY +
Sbjct: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS-GFEESDSGATKSPLHLAAYNGHHQA 557
Query: 517 LQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
L+V Q+ DL G +AL +A G+ V L
Sbjct: 558 LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
Score = 29.6 bits (65), Expect = 7.9
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 385 LSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELG-SDLGLVDFNGQTPLHAAAR 443
L L S +A+ N+ +L AA + G A+ LV +DL + D + TPLH A
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMAAEN-GQAGAVDILVNSAQADLTVKDKDLNTPLHLACS 890
Query: 444 GGHTEAVTMLLQR 456
GH + ++L +
Sbjct: 891 KGHEKCALLILDK 903
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 64.7 bits (156), Expect = 2e-10
Identities = 42/143 (29%), Positives = 73/143 (51%), Gaps = 1/143 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G +E ++ L+ +G+D+ N T L A +GG+T++V +L+R +VN D DG
Sbjct: 177 AARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG 236
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L++A + H ++ L +AG ++ + T L +E ++ Q AD+
Sbjct: 237 NTALMIASKEGHTEIVQDLLDAGTYVNIPD-RSGDTVLIGAVRGGHVEIVRALLQKYADI 295
Query: 528 GQPGYDGHSALHVAEAAGNLAVV 550
G D +AL+ A GN +V
Sbjct: 296 DIRGQDNKTALYWAVEKGNATMV 318
Score = 52.8 bits (125), Expect = 9e-07
Identities = 39/146 (26%), Positives = 68/146 (46%), Gaps = 1/146 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + + L++ G+ + D G TPL AAR GH E V LL G DV+ +
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+ L++AV+G + + + + +++ + ++ T L + E +Q AG +
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTD-KDGNTALMIASKEGHTEIVQDLLDAGTYV 262
Query: 528 GQPGYDGHSALHVAEAAGNLAVVAFL 553
P G + L A G++ +V L
Sbjct: 263 NIPDRSGDTVLIGAVRGGHVEIVRAL 288
Score = 51.6 bits (122), Expect = 2e-06
Identities = 39/139 (28%), Positives = 65/139 (46%), Gaps = 1/139 (0%)
Query: 407 AAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTD 466
+A+ G V ++ L++ G +L D G T L A G T+ V +LL G + +
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 467 GFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGAD 526
P++ A H ++ LL + GA ++ + + T L A + LE ++ GAD
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSD-KYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 527 LGQPGYDGHSALHVAEAAG 545
+ Q G + +AL VA G
Sbjct: 196 VDQEGANSMTALIVAVKGG 214
Score = 49.3 bits (116), Expect = 1e-05
Identities = 37/133 (27%), Positives = 66/133 (49%), Gaps = 3/133 (2%)
Query: 413 DVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLL 472
++ AL+AL+E D+ + GQTPL AA G+ E V L++ G + N D D ++ L+
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 473 LAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGY 532
A + H ++ L + G +L +++ T L Y+ + +++ GA+ G
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDM-GGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
Query: 533 DGHSALHVAEAAG 545
+S + AAG
Sbjct: 136 --YSVYPIIWAAG 146
Score = 48.5 bits (114), Expect = 2e-05
Identities = 37/143 (25%), Positives = 64/143 (44%), Gaps = 1/143 (0%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A + G + ++ L+ G++ + P+ AA GH + V +LLQ G VN D G
Sbjct: 111 ACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYG 170
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
+PL+ A R H + L GA + QE + T L + ++ + ++
Sbjct: 171 TTPLVWAARKGHLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229
Query: 528 GQPGYDGHSALHVAEAAGNLAVV 550
DG++AL +A G+ +V
Sbjct: 230 NLTDKDGNTALMIASKEGHTEIV 252
Score = 47.0 bits (110), Expect = 5e-05
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 33/120 (27%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTR---- 463
A+ G E +Q L++ G+ + + D +G T L A RGGH E V LLQ+ D++ R
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
Query: 464 ------------------------DT-----DGFSPLLLAVRGRHPGVIGLLREAGASLS 494
DT DG +PL+ A + R+ V+ LL + GA +S
Sbjct: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/79 (30%), Positives = 42/79 (53%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
A G+ ++ +++ D + +G+TPL A + + E V +LL +G V+ D G
Sbjct: 309 AVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKG 368
Query: 468 FSPLLLAVRGRHPGVIGLL 486
+PL +A+RGR + LL
Sbjct: 369 DTPLHIAIRGRSRKLAELL 387
Score = 35.4 bits (80), Expect = 0.14
Identities = 16/47 (34%), Positives = 27/47 (57%)
Query: 413 DVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVD 459
++E ++ L++ G+ + VD G TPLH A RG + +LL+ D
Sbjct: 347 NIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 64.3 bits (155), Expect = 3e-10
Identities = 40/134 (29%), Positives = 67/134 (50%), Gaps = 1/134 (0%)
Query: 420 LVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRH 479
L+ G+D+ L N +T LH AA+ G + V ++L G + + T GF+PL LA + H
Sbjct: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
Query: 480 PGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALH 539
++ +L GA+ Q ++ + L A + + + + + GAD P GH +H
Sbjct: 65 TEIMEMLLRKGANAHGQ-ASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
Query: 540 VAEAAGNLAVVAFL 553
VA G+L + L
Sbjct: 124 VAADRGHLLALKIL 137
Score = 55.5 bits (132), Expect = 1e-07
Identities = 44/159 (27%), Positives = 74/159 (46%), Gaps = 12/159 (7%)
Query: 403 SLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNT 462
S+ AA G+ +A+ L+E G+D + +G P+H AA GH A+ +L+ D+
Sbjct: 87 SILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLAA 145
Query: 463 RDTDGFSPLLLAVRGRHPGVIGLLREAGASLS---TQEL-----EEAGTELCRLAYRADL 514
G SP+ A G HP + LL +AG ++ Q + + + L +DL
Sbjct: 146 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 205
Query: 515 EGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
+++ AGA P D + L +A GN +++ L
Sbjct: 206 SSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLL 241
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/84 (35%), Positives = 46/84 (54%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA G + ++ ++ G+ G TPL AA+ GHTE + MLL++G + + + +D
Sbjct: 26 AAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDS 85
Query: 468 FSPLLLAVRGRHPGVIGLLREAGA 491
S LL A G +P + LL E GA
Sbjct: 86 SSILLEAASGGNPDAVALLLEYGA 109
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/178 (28%), Positives = 78/178 (43%), Gaps = 15/178 (8%)
Query: 408 AAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDG 467
AA +G E ++ L+ G++ + + L AA GG+ +AV +LL+ G D N G
Sbjct: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
Query: 468 FSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADL 527
P+ +A H + +L L+ + C A A + L++ QAG D+
Sbjct: 119 HLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAA-GAHPQCLELLIQAGFDV 176
Query: 528 G-------QPGYDGH--SALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPEPSCFQEVL 576
YD H SAL+ A + +L+ V L S GA+ Q P +C Q L
Sbjct: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLS-AGALPNQDPV---NCLQIAL 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,084,048
Number of Sequences: 37866
Number of extensions: 983953
Number of successful extensions: 4542
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 337
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2205
Number of HSP's gapped (non-prelim): 1589
length of query: 579
length of database: 18,247,518
effective HSP length: 108
effective length of query: 471
effective length of database: 14,157,990
effective search space: 6668413290
effective search space used: 6668413290
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.