Search of human proteins with 122937241

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo
sapiens]
         (1747 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap...  3516   0.0  
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1...  1342   0.0  
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...   908   0.0  
gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens]             474   e-133
gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2 ...   259   2e-68
gi|163965366 nascent polypeptide-associated complex alpha subuni...   102   3e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   102   4e-21
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        96   4e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         96   4e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         96   4e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         96   4e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         96   4e-19
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        95   7e-19
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         95   7e-19
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         95   7e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         92   3e-18
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    88   8e-17
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    87   2e-16
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                    84   1e-15
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     84   2e-15
gi|30348954 mindbomb homolog 1 [Homo sapiens]                          83   2e-15
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    83   3e-15
gi|134244285 Notch homolog 3 [Homo sapiens]                            82   3e-15
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   80   1e-14
gi|110431370 espin [Homo sapiens]                                      80   2e-14
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    79   3e-14
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    77   1e-13
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    77   1e-13
gi|55770876 notch4 preproprotein [Homo sapiens]                        77   1e-13
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...    76   3e-13

>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
          Length = 1747

 Score = 3516 bits (9116), Expect = 0.0
 Identities = 1747/1747 (100%), Positives = 1747/1747 (100%)

Query: 1    MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPS 60
            MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPS
Sbjct: 1    MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPS 60

Query: 61   RGRAGKFLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFM 120
            RGRAGKFLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFM
Sbjct: 61   RGRAGKFLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFM 120

Query: 121  DYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRT 180
            DYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRT
Sbjct: 121  DYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRT 180

Query: 181  RDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDH 240
            RDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDH
Sbjct: 181  RDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDH 240

Query: 241  AQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCAR 300
            AQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCAR
Sbjct: 241  AQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCAR 300

Query: 301  VLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAG 360
            VLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAG
Sbjct: 301  VLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAG 360

Query: 361  PSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESN 420
            PSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESN
Sbjct: 361  PSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESN 420

Query: 421  ISGPLAGRAGQSKISDPGPGPGGVGGAPLPPPGAPRSCIRIRARFPAPPAPPAPPPRGPK 480
            ISGPLAGRAGQSKISDPGPGPGGVGGAPLPPPGAPRSCIRIRARFPAPPAPPAPPPRGPK
Sbjct: 421  ISGPLAGRAGQSKISDPGPGPGGVGGAPLPPPGAPRSCIRIRARFPAPPAPPAPPPRGPK 480

Query: 481  RKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADC 540
            RKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADC
Sbjct: 481  RKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADC 540

Query: 541  VEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGF 600
            VEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGF
Sbjct: 541  VEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGF 600

Query: 601  VLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHK 660
            VLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHK
Sbjct: 601  VLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHK 660

Query: 661  QVVALIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELA 720
            QVVALIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELA
Sbjct: 661  QVVALIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELA 720

Query: 721  SIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLP 780
            SIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLP
Sbjct: 721  SIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLP 780

Query: 781  GPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPP 840
            GPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPP
Sbjct: 781  GPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPP 840

Query: 841  PAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPE 900
            PAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPE
Sbjct: 841  PAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPE 900

Query: 901  RQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAP 960
            RQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAP
Sbjct: 901  RQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAP 960

Query: 961  SKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDG 1020
            SKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDG
Sbjct: 961  SKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDG 1020

Query: 1021 PGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTA 1080
            PGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTA
Sbjct: 1021 PGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTA 1080

Query: 1081 GRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAP 1140
            GRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAP
Sbjct: 1081 GRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAP 1140

Query: 1141 SRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREE 1200
            SRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREE
Sbjct: 1141 SRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREE 1200

Query: 1201 RKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQS 1260
            RKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQS
Sbjct: 1201 RKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQS 1260

Query: 1261 AAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARI 1320
            AAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARI
Sbjct: 1261 AAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARI 1320

Query: 1321 GLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRS 1380
            GLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRS
Sbjct: 1321 GLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRS 1380

Query: 1381 SSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGK 1440
            SSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGK
Sbjct: 1381 SSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGK 1440

Query: 1441 GPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLP 1500
            GPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLP
Sbjct: 1441 GPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLP 1500

Query: 1501 GPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELS 1560
            GPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELS
Sbjct: 1501 GPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELS 1560

Query: 1561 SISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLT 1620
            SISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLT
Sbjct: 1561 SISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLT 1620

Query: 1621 PPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKP 1680
            PPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKP
Sbjct: 1621 PPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKP 1680

Query: 1681 LQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERA 1740
            LQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERA
Sbjct: 1681 LQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERA 1740

Query: 1741 LRQLDGS 1747
            LRQLDGS
Sbjct: 1741 LRQLDGS 1747


>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
            [Homo sapiens]
          Length = 1849

 Score = 1342 bits (3472), Expect = 0.0
 Identities = 849/1877 (45%), Positives = 1091/1877 (58%), Gaps = 224/1877 (11%)

Query: 7    SAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGK 66
            + +V+RV I DLQQTKC+R +P A VW AKQR+LC L  SL+D LNYGLFQP S GR GK
Sbjct: 55   NTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGK 114

Query: 67   FLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLH 126
            FLDEERLL+EYP  +   +P LEFRYK+RVY Q  +D+KQ AKLHTK NLKK MD++Q  
Sbjct: 115  FLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHR 174

Query: 127  STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA 186
              +K+ ++LD+GLDPNFHDP++GE PL+LAAQLD++ +++K LKNGGAHLDFR +DG+TA
Sbjct: 175  LVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTA 234

Query: 187  VHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGIT 246
            +H A R RN  AL TLL+LGASPDYKDS GLTPLYH+A+ GGD  CCELLLH+HA +   
Sbjct: 235  LHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCK 294

Query: 247  DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRG 306
            DENGW EIHQACR+GHVQHLEHLLFYGADM AQNASGNTALHICALYNQ+SCARVLLFRG
Sbjct: 295  DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354

Query: 307  ANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLAS 366
             N++++NYNSQT FQVAIIAGNFELAE IK HK++D+VPFRE P+Y+ RRR   P+ LA+
Sbjct: 355  GNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRR-RPPNTLAA 413

Query: 367  PRPLQRSASDINLKGEAQPAA--SPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGP 424
            PR L RS SD NL   A   A  S   S RSL  QLL Q     K         S + GP
Sbjct: 414  PRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQ--MPSKPEGAAKTIGSYVPGP 471

Query: 425  LAGRAGQSKISDPGPGPGGVGGAPLPPPGAPRSCIRIRARFPAPPAPPAPPPRGPKRKLY 484
             +     +++   G G  G    PL   G+P +    +    A   P      GPKRKLY
Sbjct: 472  RSRSPSLNRLG--GAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYP------GPKRKLY 523

Query: 485  SAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEV 544
            SAVPGR F+AVK + PQ +GEIPLHRG+ VKVLSIGEGGFWEG+ +G  GWFPA+CVEEV
Sbjct: 524  SAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEV 583

Query: 545  QMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRG 604
            Q +  D++ ETR DR+K+LFRHYTVGSYDS  + SD +I++K  VLQK+D+EGFGFVLRG
Sbjct: 584  QCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRG 643

Query: 605  AKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVA 664
            AKA+TPIEEFTPTPAFPALQYLESVD  GVAW+AGLRTGDFLIEVN  NVVKVGH+QVV 
Sbjct: 644  AKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVN 703

Query: 665  LIRQGGNRLVMKVVSVTRKPE-EDGARRRAPPPPKRAPSTTLTLRSKSMTAELEEL---A 720
            +IRQGGN LV+KVV+VTR  + +D AR++APPPPKRAP+T LTLRSKSMT+ELEEL   A
Sbjct: 704  MIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKA 763

Query: 721  SIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRI-TPAEISSLFERQGL 779
            S+R++K +   E +  A++P+   +    + R AT+KQRP+SR     ++++S++ERQG+
Sbjct: 764  SVRKKKDK--PEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGI 821

Query: 780  -------PGPEKLP--GSLRKGIPRTKSVGEDEKLASLLEG----------RFPRSTSMQ 820
                   PG  K P  G  R  + R KS+     L+ + E           +F RS SM 
Sbjct: 822  AVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMP 881

Query: 821  DPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLG 880
            D   +   IPPPPQ+ PP PP P      P     P  P  R Y T++ +F     A++ 
Sbjct: 882  DTSED---IPPPPQSVPPSPPPP-----SPTTYNCPKSPTPRVYGTIKPAFNQNSAAKV- 932

Query: 881  AGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRP 940
                    P      +    R+K    M   ++    S D+         P+   R  R 
Sbjct: 933  -------SPATRSDTVATMMREK---GMYFRRELDRYSLDSEDLYSRNAGPQANFRNKRG 982

Query: 941  PGPDSPYANLGAF-SASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAR 999
              P++PY+ +G   S +++ P+KP RRK  LVKQ  VED+ E+         P      +
Sbjct: 983  QMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSI-----PIPTIIVK 1037

Query: 1000 EPSPTHRGPRPGG----LDYGAGDGP---------------GLAFGGPGPAKDRRLEERR 1040
            EPS +  G    G    +D  A + P                 A  G    +++RLE RR
Sbjct: 1038 EPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIAGAVRDREKRLEARR 1097

Query: 1041 RSTVFLSVG--------------------------AIEGSAP--GADLPSLQPSRSIDER 1072
             S  FLS                            A E SA    + +PS  P R  +  
Sbjct: 1098 NSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATP-REPENH 1156

Query: 1073 LLGTGPT-----AGRDLLLPSPVSA--LKPLVSGPSLGPSG-STFIHPLTGKPLDPSSPL 1124
             +G         AGR L   S        P V   S G +G   ++HPLTG+ LDPSSPL
Sbjct: 1157 FVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGNYVHPLTGRLLDPSSPL 1216

Query: 1125 ALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDP-ERGSLASPAFSPRSPA 1183
            ALAL+AR+RA+     S+      +P AD   PL++D + R   + G       + R P 
Sbjct: 1217 ALALSARDRAMKE---SQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQNTRGPL 1273

Query: 1184 WIPVPARREAE---KVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRL 1240
                  R+E E   +      +  +DKK+M++ ++DTS Q+ AGL++VH     +  + L
Sbjct: 1274 -----RRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNAL 1328

Query: 1241 GGAEEERPGTPELAP------APMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPE 1294
               EE+     E+ P       P   +     L    A  P   P       GS EE   
Sbjct: 1329 --QEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVI 1386

Query: 1295 LVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPS--------- 1345
            L F   +PP  L+S D +  E+      +PPP EFAN   +    A   P+         
Sbjct: 1387 LPF--RIPPPPLASVDLD--EDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKK 1442

Query: 1346 PTTVPSPA-----------SGKPSS----------EPPPAPESAADSGVEEADTRSSSDP 1384
              T  SP+           S KP+S           PP + ++ ADSG+EE D+RSSSD 
Sbjct: 1443 SDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDH 1502

Query: 1385 HLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVT 1444
            HLETTSTISTVSS+STLSSE GE  DT T +ADG  F+++KPPVPPKPK+K  + K    
Sbjct: 1503 HLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNAL 1562

Query: 1445 FRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRG--LPGP 1502
            ++D L+++  DS ++         G   +A P   + L  R SKLWGD  E +   L GP
Sbjct: 1563 YQDALVEEDVDSFVIPPPAPPPPPG---SAQPGMAKVLQPRTSKLWGDVTEIKSPILSGP 1619

Query: 1503 EDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSSI 1562
               K  VISEL+S LQQ+N++  +   +P  GL S +  AK + +A      S   +S+I
Sbjct: 1620 ---KANVISELNSILQQMNREKLA---KPGEGLDSPMG-AKSASLAP----RSPEIMSTI 1668

Query: 1563 SAQRSPGGPGGGASYSVRPSGRYPV---------------ARRAPSPVKPASLERVEGLG 1607
            S  RS        +++VRP    P+                RRAPSPV   +    E L 
Sbjct: 1669 SGTRST-----TVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLP 1723

Query: 1608 AGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGP 1667
            A    A        P+   S   S+P +P        + + RSRSPSPS L  P S    
Sbjct: 1724 APLSAA-----TASPSPALSDVFSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPIS---- 1774

Query: 1668 GAPGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELG 1727
                  +PF  KP+ LW+K DV DWLES++LGEH++ F D+EI+G+HLP L K+D ++LG
Sbjct: 1775 -----NKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLG 1829

Query: 1728 VTRVGHRMNIERALRQL 1744
            VTRVGHRMNIERAL+QL
Sbjct: 1830 VTRVGHRMNIERALKQL 1846


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
          Length = 2161

 Score =  908 bits (2346), Expect = 0.0
 Identities = 688/1883 (36%), Positives = 886/1883 (47%), Gaps = 315/1883 (16%)

Query: 7    SAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGK 66
            S +V R+GIPDL QTKCLR +P A +W AKQ+VLCAL+ SLQD LNYGLFQP + GR   
Sbjct: 71   SMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDAN 130

Query: 67   FLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLH 126
            FL+EERLL+EYP + +  +PYLEFRYK RVY Q  +D+KQ AKLHTK  LKKF++YVQL 
Sbjct: 131  FLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLG 190

Query: 127  STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA 186
            ++DKVARLLDKGLDPN+HD DSGE PL+LAAQ + + ++++ L  GGAH+DFR RDG+TA
Sbjct: 191  TSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTA 250

Query: 187  VHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGIT 246
            +H A   R+  ALT LLDLG SP+YKD RGLTPL+H+A+ GGD  CCELLL + AQLGI 
Sbjct: 251  LHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIA 310

Query: 247  DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRG 306
            DENGWQEIHQAC+ GH QHLEHLLFYGA+ GAQNASGNTALHICALYN+E+CAR+LL+RG
Sbjct: 311  DENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRG 370

Query: 307  ANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLAS 366
            A++DV+N N QT FQVA+IAGNFEL E+I+ H++ DVVPF+E+P YA RRR    +GL  
Sbjct: 371  ADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTV 430

Query: 367  PRPLQRSASDINL----------KGEAQPAA------SPGPSLRSLPHQLLLQRLQEEKD 410
            P  L R+ SD ++           G A   A      S G S  S P   L         
Sbjct: 431  PPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSAS 490

Query: 411  RDRDADQESNISG------PLAGRAGQSKISDPGPGPGGVGGAPLPPPGAPRSCIRIRAR 464
              R A   S   G          R   S    P  GP G  G    P G+  S       
Sbjct: 491  SPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGS------- 543

Query: 465  FPAPPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGF 524
                        RG +RKLYSAVPGR F+AVK++  Q EGEI L +GE +KVLSIGEGGF
Sbjct: 544  ------------RGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGF 591

Query: 525  WEGTVKGRTGWFPADCVEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTS------- 577
            WEG VKGR GWFP+DC+EEV  R  +++ E+R D+ KRLFRHYTVGSYDS  +       
Sbjct: 592  WEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGI 651

Query: 578  --HSDYVIDDKVAVLQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVA 635
               SDY+I +K  +LQK+D EGFGFVLRGAKA+TPIEEFTPTPAFPALQYLESVD  GVA
Sbjct: 652  GPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVA 711

Query: 636  WRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPEEDGA-RRRAP 694
            WRAGLR GDFLIEVNG NVVKVGH+QVV +IRQGGN L++KVV VTR P+ D A  ++AP
Sbjct: 712  WRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAP 771

Query: 695  PPPKRAPSTTLTLRSKSMTAELEEL---------ASIRRRKG------EKLDEMLAAAAE 739
               KR P  T++LRSKSMT+ELEE+          S+ +++        KLDE+LAAA +
Sbjct: 772  QQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQ 831

Query: 740  PTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKG---IPRT 796
                 +       A+  K RP     T +        Q  P  E+ P  L  G   + R 
Sbjct: 832  TISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQ--PSYER-PSFLPPGPGLMLRQ 888

Query: 797  KSVG---EDEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPA 853
            KS+G   +D    +    +F RS S    V     IPPPP T+PP PP    + + P P+
Sbjct: 889  KSIGAAEDDRPYLAPPAMKFSRSLS----VPGSEDIPPPPTTSPPEPP----YSTPPVPS 940

Query: 854  FS---PPPPPGRAYDTVRSSFKPGL-----------EARLGAGAAGLYEPGAALGPLPYP 899
             S    P P G  ++       P             + R+G+    LY      GPLP  
Sbjct: 941  SSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHS----GPLPPA 996

Query: 900  ERQKRARSMIILQDSAPESGDA--PRPPPAAT------PPERPKRRPRP----------- 940
                            P    A  P PP   T      PP R    P+P           
Sbjct: 997  HHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPS 1056

Query: 941  --PGPDSP--YANLG-------------------AFSASLFAPSKPQR-RKSPLVKQLQV 976
              PG  SP  + + G                   A SA+++ P++  R RK PLVKQ +V
Sbjct: 1057 PTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKV 1116

Query: 977  EDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGPGPAKDRRL 1036
            E          G P  GGG     P+P+   P        A   P  A   P       +
Sbjct: 1117 E----------GEPQKGGG---LPPAPSPTSP--------ASPQPPPAVAAPSEKNSIPI 1155

Query: 1037 EERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPL 1096
                  T+ +   +   S   +   S +          G G   G     PSP  A+ P+
Sbjct: 1156 -----PTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSS---PSPAPAMSPV 1207

Query: 1097 VSGPSLGPSGSTFIHPLTGKPLDPSSPLALAL---AARERALASQAPSRSPTPVHSPDAD 1153
               PS  P+ ++   P T   LD +S    AL   A RE    ++A  RS   + +   D
Sbjct: 1208 PPSPSPVPTPASPSGPAT---LDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGD 1264

Query: 1154 R------------PGPLF-----VDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKV 1196
                         PGP       +D      E       A S          +R      
Sbjct: 1265 EDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGG 1324

Query: 1197 PREERKSPEDKKSMILSVLDTSLQRPAGL-IVVHATSNGQEPSRLGGAEEERPGTPELAP 1255
                  S    + ++  +   +L   + L + + A     + S  GG   + P  P   P
Sbjct: 1325 GSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRP---P 1381

Query: 1256 APMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEP---ELVFAVNLPPAQLSSSDEE 1312
            +P   A    P P+P    P           G+S  +P   EL +   L   + S     
Sbjct: 1382 SPRYEA----PPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASP 1437

Query: 1313 TREELARIGLVPPPEEFANGVLLATPLAGPGPSP-------TTVP--------------- 1350
                 + +  +PP       +LL      P P P       +  P               
Sbjct: 1438 PAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLEN 1497

Query: 1351 -------SPASGKPSSEPPPAPESAADSGVEEADT--RSSSDPHLETTSTISTVSSMSTL 1401
                   +   G PS + P  P  +    V  + T  R+S +  L          S+   
Sbjct: 1498 CQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDV- 1556

Query: 1402 SSESGEL---------TDTHTSFADGHTFLLEKPPVP----PKPKLKSPLGKGPVTFRDP 1448
              E GE           +   SF    + L   PP P    P P    P    P     P
Sbjct: 1557 --EDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAP 1614

Query: 1449 LLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPT 1508
                S+ S L +     A+    ++A P  P           G P  +   P      P 
Sbjct: 1615 PTLDSTASSLTSYDSEVATLTQGASAAPGDPHPP--------GPPAPAAPAPAAPQPGPD 1666

Query: 1509 VISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSSISAQRSP 1568
                  S ++++  D+RS  + P+  + S                S+L  LS+     + 
Sbjct: 1667 PPPGTDSGIEEV--DSRSSSDHPLETISSA---------------STLSSLSAEGGGSAG 1709

Query: 1569 GGPGGGASYSVRP----------SGRYPVARRAPSPVKPASL---ERVEGLGAGAGGAGR 1615
            GG G GA  +  P           G+       P P  P  L    ++ G   GA G  R
Sbjct: 1710 GGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLR 1769

Query: 1616 P---FGLTPPTILKSSSLSIPHEPKEVRFVVRSVS------------ARSRSPSPSPLPS 1660
            P    GL  P    S ++S+     +    +R+ S            A      P PLP+
Sbjct: 1770 PGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPT 1829

Query: 1661 PASGP--------GPGAPGPRRP 1675
             +S P        GPG P P  P
Sbjct: 1830 ASSLPRKLLPWEEGPGPPPPPLP 1852



 Score =  259 bits (663), Expect = 1e-68
 Identities = 368/1259 (29%), Positives = 474/1259 (37%), Gaps = 320/1259 (25%)

Query: 761  TSRRITPAEISSLFER-QGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSM 819
            +S R+TP+     F    G P P   P S     P    VG  EK +    G  P +   
Sbjct: 941  SSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREK-SLYHSGPLPPAHHH 999

Query: 820  QDPVREGRGIPPPPQTAPPPPPAPYYFDSG-----PPPAFSPPPPPG-RAYDTVRSSFKP 873
                      PP P      PP P   ++G     PPP  +  P P  R +     S  P
Sbjct: 1000 PPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTP 1059

Query: 874  GLEARLGAGAAG--------------LYEPGAALGPLPYPERQKRARSMIILQ----DSA 915
            G  +    G+AG                 P AA   +  P R  R R   +++    +  
Sbjct: 1060 GAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGE 1119

Query: 916  PESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQ 975
            P+ G    P P+ T P  P+  P    P S   ++   +  + APS     +S      +
Sbjct: 1120 PQKGGGLPPAPSPTSPASPQPPPAVAAP-SEKNSIPIPTIIIKAPSTSSSGRSSQGSSTE 1178

Query: 976  VEDAQERAALAVG-------SPGPGGGSFAREPSPTHRGPRPGG---LDYGAGDGPGLAF 1025
             E   +      G       SP P        PSP      P G   LD+ +  G  L  
Sbjct: 1179 AEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALV- 1237

Query: 1026 GGPGPAKDRRLEERRRSTVFLSVGAIE----------GSAPGADLPSLQPSRSIDERLLG 1075
            G        + E RRRST+FLS  A +          G+APG   P L+ S+SIDE +  
Sbjct: 1238 GAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPG---PRLRHSKSIDEGMFS 1294

Query: 1076 TGPTAGRDLLLPSPVSALK-------PLVSGPSLGPSGST-------FIHPLTGKPLDPS 1121
              P     L L S  S              G   G S  T        +HPLTGK LDP+
Sbjct: 1295 AEPY----LRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPA 1350

Query: 1122 SPLALALAARERAL--------ASQAPSRSPTPV----------HSPDADRPGPLFV-DV 1162
            SPL LALAARERAL        A Q P R P+P           HSP A     L +   
Sbjct: 1351 SPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGA 1410

Query: 1163 QARDPERGSLASPAFSPRSPAWIPV--PARREAEKVPREERKSPEDKKSMILSVLDTSLQ 1220
               DP R  L   A        +P   PA R +        + P     +   +L    +
Sbjct: 1411 SPPDPARRELGYRAGLGSQEKSLPASPPAARRSLL-----HRLPPTAPGVGPLLLQLGTE 1465

Query: 1221 RPA---GLIVVHATSNGQEPSRL--------------------GGAEEERPGTPELAPAP 1257
             PA   G+     ++  +EP RL                    G   E+ PG P   P+P
Sbjct: 1466 PPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPP--PSP 1523

Query: 1258 MQSAAVAEPLP-SPRAQPPGGTPADAGPGQGSSE--EEPELVFAVNLPPA-QLSSSDEET 1313
             +S     P P SPRA    G P    P    S   E+ E +F   LPP  + S+S E+ 
Sbjct: 1524 RRSVP---PSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKP 1580

Query: 1314 REELAR---------------IGLVPPPEEFANGVLL--------------ATPLAG--- 1341
               L                 +  VPPP   A    L              AT   G   
Sbjct: 1581 ESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASA 1640

Query: 1342 -------PGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRSSSDPHLETTSTIST 1394
                   PGP     P+PA+ +P  +PPP      DSG+EE D+RSSSD  LET S+ ST
Sbjct: 1641 APGDPHPPGPPAPAAPAPAAPQPGPDPPPG----TDSGIEEVDSRSSSDHPLETISSAST 1696

Query: 1395 VSSMSTLSSESG--------------ELTDTHTSFADGHTFLLEKPPVPP-KPKLKSP-- 1437
            +SS+S     S               EL DT+ ++ DG  F     P PP  P+L +P  
Sbjct: 1697 LSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSK 1756

Query: 1438 -----------LGKGPVT-FRDPLLKQS---------SDSELMAQQHH----AASAGLAS 1472
                       L  GP    RDP+   S         +D  L  +       A  AG   
Sbjct: 1757 LRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPV 1816

Query: 1473 AAGPARPRYLFQRRSKL------W--GDPVESRGLPGPEDD---------KPTVISELSS 1515
            A  P  P       S L      W  G       LPGP            K ++ISELSS
Sbjct: 1817 AVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSS 1876

Query: 1516 RLQQLNKDTRSLGEEPV--GGLGSLLD---------PAKKSPIAAARL------------ 1552
            +LQQ    + + G  P   GG G   D         P + S +   RL            
Sbjct: 1877 KLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKP 1936

Query: 1553 FSSL--------------GELSSISAQRSPGGPGGGASYS---------VRPSGRYPVAR 1589
             SSL              G   S +A  +PG     AS S         V    R P+ R
Sbjct: 1937 VSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLR 1996

Query: 1590 RAPSP-VKPASLERVE------------------GL-------GAGAGGAGRPFGLTPPT 1623
            RAPSP + PAS  +V                   GL         GAGG+  PF      
Sbjct: 1997 RAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPF------ 2050

Query: 1624 ILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKPLQL 1683
                + + +P  P     +  ++S  SRS SP+ L S           P +PF  KPL  
Sbjct: 2051 ----APVFVPPHPGISGGLGGALSGASRSLSPTRLLSLP---------PDKPFGAKPLGF 2097

Query: 1684 WSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERALR 1742
            W+KFDV DWLE + L EHR +F DHEI+G+HLPALTK+D+V+LGVTRVGHRMNI+RAL+
Sbjct: 2098 WTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALK 2156



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 53/158 (33%), Positives = 65/158 (41%), Gaps = 39/158 (24%)

Query: 1561 SISAQRSPGGPGGGASYSV-RPSGRY-------PVARRAPSPVKPASLERVEGL-----G 1607
            +ISA  SPG PGG AS    RP G +       P  R  PS  +P+ L    GL      
Sbjct: 832  TISASESPG-PGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKS 890

Query: 1608 AGAGGAGRPFGLTPPTILKSSSLSIPHE----------PKEVRFVVRSVSARSRSPSPSP 1657
             GA    RP+ L PP +  S SLS+P            P E  +    V + S   +PSP
Sbjct: 891  IGAAEDDRPY-LAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSP 949

Query: 1658 ------------LP--SPASGPGPGAPGPRRPFQQKPL 1681
                        LP  SPAS  GP  P  R   ++K L
Sbjct: 950  RGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSL 987


>gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens]
          Length = 385

 Score =  474 bits (1221), Expect = e-133
 Identities = 222/322 (68%), Positives = 266/322 (82%)

Query: 7   SAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGK 66
           + +V+RV I DLQQTKC+R +P A VW AKQR+LC L  SL+D LNYGLFQP S GR GK
Sbjct: 55  NTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGK 114

Query: 67  FLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLH 126
           FLDEERLL+EYP  +   +P LEFRYK+RVY Q  +D+KQ AKLHTK NLKK MD++Q  
Sbjct: 115 FLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHR 174

Query: 127 STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA 186
             +K+ ++LD+GLDPNFHDP++GE PL+LAAQLD++ +++K LKNGGAHLDFR +DG+TA
Sbjct: 175 LVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTA 234

Query: 187 VHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGIT 246
           +H A R RN  AL TLL+LGASPDYKDS GLTPLYH+A+ GGD  CCELLLH+HA +   
Sbjct: 235 LHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCK 294

Query: 247 DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRG 306
           DENGW EIHQACR+GHVQHLEHLLFYGADM AQNASGNTALHICALYNQ+SCARVLLFRG
Sbjct: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354

Query: 307 ANRDVRNYNSQTAFQVAIIAGN 328
            N++++NYNSQT FQV  I+ +
Sbjct: 355 GNKELKNYNSQTPFQVKEISAS 376


>gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2
           [Homo sapiens]
          Length = 281

 Score =  259 bits (661), Expect = 2e-68
 Identities = 144/249 (57%), Positives = 185/249 (74%), Gaps = 16/249 (6%)

Query: 567 YTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYL 626
           Y  G     + +SD +I++K  VLQK+D+EGFGFVLRGAKA+TPIEEFTPTPAFPALQYL
Sbjct: 18  YNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYL 77

Query: 627 ESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPE- 685
           ESVD  GVAW+AGLRTGDFLIEVN  NVVKVGH+QVV +IRQGGN LV+KVV+VTR  + 
Sbjct: 78  ESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDP 137

Query: 686 EDGARRRAPPPPKRAPSTTLTLRSKSMTAELEEL---ASIRRRKGEKLDEMLAAAAEPTL 742
           +D AR++APPPPKRAP+T LTLRSKSMT+ELEEL   AS+R++K +   E +  A++P+ 
Sbjct: 138 DDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDK--PEEIVPASKPSR 195

Query: 743 RPDIADADSRAATVKQRPTSRRI-TPAEISSLFERQGL-------PGPEKLP--GSLRKG 792
             +    + R AT+KQRP+SR     ++++S++ERQG+       PG  K P  G  R  
Sbjct: 196 AAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGT 255

Query: 793 IPRTKSVGE 801
           + R KS+G+
Sbjct: 256 MRRQKSIGK 264


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  102 bits (254), Expect = 3e-21
 Identities = 241/1048 (22%), Positives = 343/1048 (32%), Gaps = 155/1048 (14%)

Query: 693  APPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIADADSR 752
            A P PK+AP+ ++T  S            I      K      A   P   P        
Sbjct: 901  ATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPK-----GAPTPPAATPPSPKGGPA 955

Query: 753  AATVKQRPTSRRITPAEIS---SLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLL 809
              + K  PT    TP       +    +G P P        KG P T S  +       +
Sbjct: 956  TPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSP-KGAPTPPAV 1014

Query: 810  EGRFPRSTSMQDPVREGRGIPP-----------------------PPQTAPPP---PPAP 843
                P+ +    P  +G   PP                       P  T P P   P  P
Sbjct: 1015 TPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATP 1074

Query: 844  YYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQK 903
                +  PPA +PP P G           P   +  GA       P +  G L  P   K
Sbjct: 1075 SLKGAPTPPAATPPSPKGG----------PATPSPKGAPMPPAATPPSPKGGLATPPH-K 1123

Query: 904  RARSMIILQDSAPESGDAPRPP------PAATPPERPKRRPRPP---GPDSPYANLGAFS 954
             A +       +P+ G A  PP      PAATPP        PP    P +P A   +  
Sbjct: 1124 GAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1183

Query: 955  ASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRG----PRP 1010
              L  PS      +P            +  LA  SP     + A  P P+ +G    P P
Sbjct: 1184 GGLATPSPKGAPTTPAATP-----PSPKGGLATPSPKGAPTTPAATP-PSPKGGLATPSP 1237

Query: 1011 GGLDYGAGDGPGLAFGGPGPAKDRRLEERRRSTV-FLSVGAIEGSAPGADLPSLQPSRSI 1069
             G        P    GGP     +       +T   L  G       GA  P++    S 
Sbjct: 1238 KGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSP 1297

Query: 1070 DERLLGTGPTAGRDLLLPSPVSALKPLVSG-PSLGPSGSTFIHPLTGKPLDPSSPLALAL 1128
                   GP        P+P +A  P   G P   P       P    P    +P   A 
Sbjct: 1298 KG-----GPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPAT 1352

Query: 1129 AARERALASQAPSRS-PTPVHSPDADRPGPLFVDVQARDPERG-SLASPAFSPRSPAWIP 1186
                +   +   S+  PTP  +  + + GP         P+RG ++ SP   P SPA IP
Sbjct: 1353 TPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPS---PKRGPAIPSPKGDPTSPAVIP 1409

Query: 1187 V-PARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQE-PSRLGGAE 1244
            + P +  A  V RE   +P        +V   SL++        A   G   PS  G   
Sbjct: 1410 LSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPA---TSAPKGGPATPSSKGDPT 1466

Query: 1245 --EERPGTPELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLP 1302
                 P +P+  PAP Q A  + P  +P    P G P        S +E P    +   P
Sbjct: 1467 LPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDP 1526

Query: 1303 PAQLSS-SDEETREELA-RIGLVPPPEEFANGVLLATPLAGPG-PSPTTVPSPASGKPSS 1359
             A  ++   ++T   LA +  L+PP       + + +P   P  P+P   P+  S K +S
Sbjct: 1527 IAPTATLLSKKTPATLAPKEALIPP------AMTVPSPKKTPAIPTPKEAPATPSSKEAS 1580

Query: 1360 EPP---PAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFA 1416
             PP   P+    A S  E     + + P   +     T  +++  S E G  T       
Sbjct: 1581 SPPAVTPSTYKGAPSPKELLIPPAVTSP---SPKEAPTPPAVTPPSPEKGPATPAPKGTP 1637

Query: 1417 DGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGP 1476
                     PPV P     SP     VT +            M      AS GL +  GP
Sbjct: 1638 -------TSPPVTPSSLKDSPTSPASVTCK------------MGATVPQASKGLPAKKGP 1678

Query: 1477 ARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLG 1536
               + +                L  P  +   +I+  + +  Q  K   S    P+    
Sbjct: 1679 TALKEV----------------LVAPAPESTPIITAPTRKGPQTKKS--SATSPPI---- 1716

Query: 1537 SLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGPGGGASYSVRPSGRY-PVARRAPSPV 1595
               DP+ K+         +   L  +    S    G  AS+S  P G   P   +A +P+
Sbjct: 1717 -CPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHS--PKGPLAPPESKASTPL 1773

Query: 1596 KPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSP 1655
              A+ E+V      A  +  P   +PP  L  +   +P  P + +F+  S      SPS 
Sbjct: 1774 TAAAFEKVLPKPESASVSAAP---SPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSK 1830

Query: 1656 SPLPS------PASGPGPGAPGPRRPFQ 1677
               P+      P   P P + G   PFQ
Sbjct: 1831 PLAPADEDELLPLIPPEPISGGV--PFQ 1856



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 246/1048 (23%), Positives = 330/1048 (31%), Gaps = 227/1048 (21%)

Query: 694  PPPPKRAP--STTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIADADS 751
            PP PK AP  S    L  K +T   +E  +        ++         T  P  A A S
Sbjct: 858  PPSPKGAPTPSAVTPLSPKGVTLPPKETPT-----PSVVNLPFPKEGPATPAPKQAPALS 912

Query: 752  RAATVKQRPTSRRITPAE--ISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLL 809
              ++    P   R TPA   I +    +G P P        KG P T S     K A   
Sbjct: 913  MTSS---SPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPS----PKWAPTP 965

Query: 810  EGRFPRSTSMQDPVREGRGIPPPPQTAPPPP---PAPYYFDSGP-PPAFSPPPPPGRAYD 865
                P S          +G P PP   PP P   PA       P PPA +PP P G    
Sbjct: 966  PAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKG---- 1021

Query: 866  TVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRP- 924
                           + AA  +  GA+  P   P   K + +   L   AP +  A  P 
Sbjct: 1022 ---------------SPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066

Query: 925  ---------------PPAATPPE--------RPKRRPRPPG--PDSPYANLGAFSASLFA 959
                           PPAATPP          PK  P PP   P SP   L A      A
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGL-ATPPHKGA 1125

Query: 960  PSKPQRRK-SPLVKQLQVEDAQERAALAVGSPGPGGGSFAREP-----SPTHRGPRPGGL 1013
            P+ P     SP                A   P P GG     P     +P    P P G 
Sbjct: 1126 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG- 1184

Query: 1014 DYGAGDGPGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERL 1073
                    GLA   P  A               +  A    +P   L +  P +      
Sbjct: 1185 --------GLATPSPKGAP--------------TTPAATPPSPKGGLATPSP-KGAPTTP 1221

Query: 1074 LGTGPTAGRDLLLPSPVSA-LKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARE 1132
              T P+    L  PSP  A   P  + PS  P G     P T  P    +P A    + +
Sbjct: 1222 AATPPSPKGGLATPSPKGAPTTPAATPPS--PKGG----PATPPPKGAPTPPAATPPSLK 1275

Query: 1133 RALASQAPSRSPTP-VHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIP-VPAR 1190
              LA+     +P P V +P + + GP      A  P +G+   PA +P SP   P  P  
Sbjct: 1276 GGLATPPHKGAPNPAVVTPPSPKGGP------ATSPPKGAPTPPAATPPSPKGSPGTPPP 1329

Query: 1191 REAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGT 1250
            + A   P     SP+                  G   + AT+    PS  GG     P T
Sbjct: 1330 KGAPTPPAVTPPSPK------------------GTPTLPATT----PSSKGG-----PTT 1362

Query: 1251 PELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSD 1310
            P     P   AA       P   PP       GP   S + +P     + L P +  ++ 
Sbjct: 1363 PSSKEGPTPPAATPSHKGGPAMTPPS---PKRGPAIPSPKGDPTSPAVIPLSPKKAPATP 1419

Query: 1311 EETREELA---RIGLVPP---PEEFANGVLLATPLAGPG-PSPTTVPS-PASGKPSSEPP 1362
              TRE  A   +  L PP   P         + P  GP  PS    P+ PA   PS + P
Sbjct: 1420 V-TREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEP 1478

Query: 1363 PAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTS----FADG 1418
            PAP+  A        T SS      T + +   +  + + S   E+  T +S     A  
Sbjct: 1479 PAPKQVA--------TSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPT 1530

Query: 1419 HTFLLEKPP--VPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGP 1476
             T L +K P  + PK  L  P    P   + P +    ++        A+S    +    
Sbjct: 1531 ATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVT---- 1586

Query: 1477 ARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLG 1536
                            P   +G P P++                                
Sbjct: 1587 ----------------PSTYKGAPSPKE-------------------------------- 1598

Query: 1537 SLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGP---GGGASYSVRPSGRYPVARRAPS 1593
             L+ PA  SP  + +   +   ++  S ++ P  P   G   S  V PS          S
Sbjct: 1599 LLIPPAVTSP--SPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSL------KDS 1650

Query: 1594 PVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSP 1653
            P  PAS+    G        G P    P  + +      P     +    R      +S 
Sbjct: 1651 PTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSS 1710

Query: 1654 SPSPLPSPASGPGPGAPGPRRPFQQKPL 1681
            + SP   P      G+ GP       PL
Sbjct: 1711 ATSPPICPDPSAKNGSKGPLSTVAPAPL 1738



 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 226/938 (24%), Positives = 320/938 (34%), Gaps = 158/938 (16%)

Query: 839  PPPAPYYFDSGPPPAFSPPPPPGRA-YDTVRSSFKPGLEARLGAGAAGLYEPGAALGPL- 896
            P  A +  +S  P   +P    G + Y T  S F  G  + L      + E      PL 
Sbjct: 643  PTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVS-LAPKNHPVKEGTLTTLPLV 701

Query: 897  ----------PYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPK---------RR 937
                      P P+      + ++L    P+S  +P  PPA TPP   K           
Sbjct: 702  PTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALA 761

Query: 938  PRPPGP-DSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGG-- 994
            P    P + P  + GA + +    +      SP    + V    +R     GS GP    
Sbjct: 762  PVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPI 821

Query: 995  GSFAREPSPTHRGPRP-GGLDY-GAGDGPGLAF--------GGPGPAKDRRLEERR---- 1040
            G+ +   SP      P   L + G+ D P            G P P+    L  +     
Sbjct: 822  GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLP 881

Query: 1041 -RSTVFLSVGAI----EGSAPGA--DLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSAL 1093
             + T   SV  +    EG A  A    P+L  + S  ++   T    G     PSP  A 
Sbjct: 882  PKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPAS-PSPKGAP 940

Query: 1094 KPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTP-VHSPDA 1152
             P  + P   P G     P T  P    +P A    + +   A+ +P  +PTP   +P +
Sbjct: 941  TPPAATPP-SPKGG----PATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPS 995

Query: 1153 DRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPV--PARREAEKVPREERKSPEDKKSM 1210
             + GP      A    +G+   PA +P SP   P   P  + A   P     SP+   + 
Sbjct: 996  PKGGP------ATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAA 1049

Query: 1211 ILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQSAAVAEPLPSP 1270
                  T L + A       T     PS  GG     P TP L  AP   AA     PSP
Sbjct: 1050 ------TPLPKGAP-----TTPAATLPSPKGG-----PATPSLKGAPTPPAATP---PSP 1090

Query: 1271 RAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFA 1330
            +  P   TP+  G     +   P     +  PP + + +         + GL  PP + A
Sbjct: 1091 KGGP--ATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGA 1148

Query: 1331 NGVLLATP------LAGPGP--SPT----TVPSPASGKPSSEPPPAPESAADSGVEEADT 1378
                 ATP      LA P P  +PT    T PSP  G  +  P  AP + A +       
Sbjct: 1149 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1208

Query: 1379 RSSSDPHLETTSTISTVSS----MSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKL 1434
             ++  P    T+  +T  S    ++T S +    T   T             P  PK   
Sbjct: 1209 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT-------------PPSPKGGP 1255

Query: 1435 KSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLA------SAAGPAR--PRYLFQRR 1486
             +P  KG  T   P     S    +A   H  +   A         GPA   P+      
Sbjct: 1256 ATPPPKGAPT--PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPP 1313

Query: 1487 SKLWGDPVESRGLPGPED-DKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKK- 1544
            +     P  S G P P+    P  ++  S       K T +L        G    P+ K 
Sbjct: 1314 AATPPSPKGSPGTPPPKGAPTPPAVTPPSP------KGTPTLPATTPSSKGGPTTPSSKE 1367

Query: 1545 --SPIAAARLFSSLGELSSISAQRSPGGP---GGGASYSVRP-----SGRYPVARR---- 1590
              +P AA         ++  S +R P  P   G   S +V P     +   PV R     
Sbjct: 1368 GPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAAT 1427

Query: 1591 ------APSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVR 1644
                   P  V P SL++     A  GG   P     PT L + +   P EP   + V  
Sbjct: 1428 PSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPT-LPAVTPPSPKEPPAPKQVAT 1486

Query: 1645 SVSARSRSPSPSPLPSPA------SGPG--PGAPGPRR 1674
            S S +    +P+P+ +P       S P   P  P  RR
Sbjct: 1487 SSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRR 1524



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 235/1031 (22%), Positives = 333/1031 (32%), Gaps = 193/1031 (18%)

Query: 696  PPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAAT 755
            PP   P  T  +   S T+ L  +AS  +    +     A A+       +AD+ S    
Sbjct: 740  PPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGV 799

Query: 756  VKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPR 815
                 T R  T         ++G  GP+   G+L   +   ++       + L E     
Sbjct: 800  SVSPQTKRPPT---------KKGSAGPDTPIGNLSSPVSPVEA-------SFLPENSLSF 843

Query: 816  STSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGP--PPAFSPPPP------PGRAYDTV 867
              S   P       PP P+ AP P         G   PP  +P P       P     T 
Sbjct: 844  QGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATP 903

Query: 868  RSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDA-PRP-- 924
                 P L     +       P  A   +P     K A +       +P+ G A P P  
Sbjct: 904  APKQAPALSMTSSSPKKARATP--APKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKW 961

Query: 925  ---PPAATPPERPKRRPRPPGPD-SPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQ 980
               PPAATPP  PK  P  P P  +P        +    P+ P  + +P    +     +
Sbjct: 962  APTPPAATPPS-PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPK 1020

Query: 981  ERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGP--GPAKDRRLEE 1038
               A      G      A  PSP    P    L  GA   P      P  GPA       
Sbjct: 1021 GSPAATPFPKGASTPPAATPPSPKG-SPAATPLPKGAPTTPAATLPSPKGGPATP----- 1074

Query: 1039 RRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPLVS 1098
                           S  GA  P              T P+       PSP  A  P  +
Sbjct: 1075 ---------------SLKGAPTPPA-----------ATPPSPKGGPATPSPKGAPMPPAA 1108

Query: 1099 GPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPT-PVHSPDADRPGP 1157
             P   P G     P  G P  P    A    + +  LA+  P  +PT P  +P + + G 
Sbjct: 1109 TPP-SPKGGLATPPHKGAPTTP----AATPPSPKGGLATPPPKGAPTTPAATPPSPKGG- 1162

Query: 1158 LFVDVQARDPERGSLASPAFSPRSP-AWIPVPARREAEKVPREERKSPEDKKSMILSVLD 1216
                  A  P +G+  +PA +P SP   +  P+ + A   P     SP+           
Sbjct: 1163 -----LATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK----------- 1206

Query: 1217 TSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQPPG 1276
                   GL           PS  G      P TP   P P     +A P P      P 
Sbjct: 1207 ------GGLAT---------PSPKGA-----PTTPAATP-PSPKGGLATPSPKGAPTTPA 1245

Query: 1277 GTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLA 1336
             TP    P  G +   P+       PPA    S         + GL  PP + A    + 
Sbjct: 1246 ATPPS--PKGGPATPPPK---GAPTPPAATPPS--------LKGGLATPPHKGAPNPAVV 1292

Query: 1337 TPLAGPGPSPTTVPSPASGKPSSEPPP---APESAADSGVEEADTRSSSDPHLETTSTIS 1393
            TP +  G   T+ P  A   P++ PP    +P +    G       +   P    T   +
Sbjct: 1293 TPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPAT 1352

Query: 1394 TVSSM---STLSSESGELTDTHTSFADGHTFLLEKPPVPPK-PKLKSPLGKGPVTFRDPL 1449
            T SS    +T SS+ G      T    G   +   PP P + P + SP G        PL
Sbjct: 1353 TPSSKGGPTTPSSKEGPTPPAATPSHKGGPAM--TPPSPKRGPAIPSPKGDPTSPAVIPL 1410

Query: 1450 LKQSSDSELMAQQHHA-------------------ASAGLASAAGPARPRYLFQRRSKLW 1490
              + + +  + ++  A                   A A  A   GPA P       SK  
Sbjct: 1411 SPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATP------SSK-- 1462

Query: 1491 GDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAA 1550
            GDP      P    + P      +S   +    T +    P+G           +P   A
Sbjct: 1463 GDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPA----PMG-----------APTLPA 1507

Query: 1551 RLFSSLGEL-SSISAQRSPGGPGGGASYSVRPS------GRYPVARRAPSPVKPASLERV 1603
             + SS  E+ ++ S++R P  P         P+         P A   PSP K  ++   
Sbjct: 1508 VIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTP 1567

Query: 1604 EGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSP----LP 1659
            +   A           +PP +  S+    P  PKE+  +  +V++ S   +P+P     P
Sbjct: 1568 KEAPATPSSKE---ASSPPAVTPSTYKGAP-SPKEL-LIPPAVTSPSPKEAPTPPAVTPP 1622

Query: 1660 SPASGPGPGAP 1670
            SP  GP   AP
Sbjct: 1623 SPEKGPATPAP 1633



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 119/489 (24%), Positives = 171/489 (34%), Gaps = 95/489 (19%)

Query: 1194 EKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPEL 1253
            E VP  E++ P+ +    +  + ++L   A L        GQ      G     P +P  
Sbjct: 7    ETVPATEQELPQPQAETAVLPMSSALSVTAAL--------GQP-----GPTLPPPCSPAP 53

Query: 1254 APAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEET 1313
               P+ +A  A P PSP       TP +    Q SS     L  A   P    +      
Sbjct: 54   QQCPLSAANQASPFPSP--STIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPN------ 105

Query: 1314 REELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGV 1373
                    L+ PP   A     A  LA P  +PT   +P+S  P +    AP S   S  
Sbjct: 106  --------LIGPPISPA-----ALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKS-- 150

Query: 1374 EEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFL-LEKPP--VPP 1430
                  S+  P+L T       S  S   +ESG +       A       L K P  V P
Sbjct: 151  ------SAFPPNLLT-------SPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVP 197

Query: 1431 KPK-LKSP---LGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRR 1486
             PK   SP   +   P     P+    S    + Q     +  +AS      P+      
Sbjct: 198  NPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIAS------PQVKDTTI 251

Query: 1487 SKLWGDPVE--SRGLPGPEDDKPTVISELSSRLQQLNKDTRSLG-----EEPVGGLGSLL 1539
            S +   P    S  L GP    P  +S  +  L  +    ++ G     + P+  LGS L
Sbjct: 252  SSVLISPQNPGSLSLKGPV-SPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPI-SLGSHL 309

Query: 1540 DPAKKSPIAAARLFSSLG-------ELSSISAQRSPGGPGGGASYSVRPS---------- 1582
             P  +S   + +L    G        + +IS   S  G    +  SV P           
Sbjct: 310  APLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPA 369

Query: 1583 --GRYPVARRAPSPVK-PASLERVEGLGAGAGGAGRPFGLTPPT--ILKSSSLSIPHEPK 1637
                +PV   APS  K P+++  +    +G+      F L+P T  ILKSS  +  H P 
Sbjct: 370  TVAAFPVV--APSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPL 427

Query: 1638 EVRFVVRSV 1646
              +  V SV
Sbjct: 428  VAQMPVSSV 436



 Score = 32.7 bits (73), Expect = 3.2
 Identities = 36/143 (25%), Positives = 49/143 (34%), Gaps = 23/143 (16%)

Query: 361  PSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESN 420
            P  +  P P    A+    KG + P A+  PS +  P    L +              + 
Sbjct: 1011 PPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK-------GAPTTPAAT 1063

Query: 421  ISGPLAGRAGQSKISDP------------GPGPGGVGGAPLPP---PGAPRSCIRIRARF 465
            +  P  G A  S    P            GP      GAP+PP   P +P+  +      
Sbjct: 1064 LPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHK 1123

Query: 466  PAPPAPPAPPPRGPKRKLYSAVP 488
             AP  P A PP  PK  L +  P
Sbjct: 1124 GAPTTPAATPP-SPKGGLATPPP 1145



 Score = 32.0 bits (71), Expect = 5.4
 Identities = 37/133 (27%), Positives = 52/133 (39%), Gaps = 10/133 (7%)

Query: 674  VMKVVSVTRKPEEDGARRRAP-PPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDE 732
            V K  S T K ++     + P  PP+   ST LT  +        E AS+       +  
Sbjct: 1741 VQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSL 1800

Query: 733  MLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPG----- 787
             LA +  PTL P      S    V + P S+ + PA+   L     L  PE + G     
Sbjct: 1801 PLAPSPVPTLPPKQQFLPSSPGLVLESP-SKPLAPADEDELLP---LIPPEPISGGVPFQ 1856

Query: 788  SLRKGIPRTKSVG 800
            S+   +P  KS G
Sbjct: 1857 SVLVNMPTPKSAG 1869


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  102 bits (253), Expect = 4e-21
 Identities = 69/202 (34%), Positives = 103/202 (50%), Gaps = 4/202 (1%)

Query: 129 DKVARLL-DKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAV 187
           + VARLL  +  DPN H+ + G+ PL +AA   + + L+K+L + GA LD + R+  T +
Sbjct: 474 ENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGHVS-LVKLLTSQGAELDAQQRNLRTPL 531

Query: 188 HCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITD 247
           H A  +    A+  LL  GA PD  D  G  PL H+A   G  L C++LL   A L +  
Sbjct: 532 HLAVERGKVRAIQHLLKSGAVPDALDQSGYGPL-HTAAARGKYLICKMLLRYGASLELPT 590

Query: 248 ENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGA 307
             GW  +H A   GH++ +  L    A+MGA  A   T LH+ A + +E+    LL  GA
Sbjct: 591 HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGA 650

Query: 308 NRDVRNYNSQTAFQVAIIAGNF 329
           + +    +  T   +A+    F
Sbjct: 651 DPNAAEQSGWTPLHLAVQRSTF 672



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 78/275 (28%), Positives = 119/275 (43%), Gaps = 23/275 (8%)

Query: 69  DEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLH-------TKANLKKFMD 121
           DEE  + E   N  TPL +L         AQ  ++  +    H       T +     + 
Sbjct: 353 DEELCIYE---NKVTPLHFL--------VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLI 401

Query: 122 YVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATD-LLKVLKNGGAHLDFRT 180
             Q    D  A LL  G D N  D D G  PL  AAQ  N  D   ++L + GA +D + 
Sbjct: 402 AAQDQQPDLCALLLAHGADANRVDED-GWAPLHFAAQ--NGDDGTARLLLDHGACVDAQE 458

Query: 181 RDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDH 240
           R+G T +H A +         L+   A P+  ++ G TPL+ +A  G  +L  +LL    
Sbjct: 459 REGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV-KLLTSQG 517

Query: 241 AQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCAR 300
           A+L     N    +H A   G V+ ++HLL  GA   A + SG   LH  A   +    +
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICK 577

Query: 301 VLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           +LL  GA+ ++  +   T   +A   G+ E+  ++
Sbjct: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLL 612



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 60/219 (27%), Positives = 97/219 (44%), Gaps = 3/219 (1%)

Query: 127 STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA 186
           S ++V  LL   +D +     SG  PL +AAQ D   DL  +L   GA  +    DG   
Sbjct: 374 SVEQVRLLLAHEVDVDCQTA-SGYTPLLIAAQ-DQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 187 VHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGIT 246
           +H A +  +      LLD GA  D ++  G TPL+ +A    + +   LL+   A   + 
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA-RLLVSRQADPNLH 490

Query: 247 DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRG 306
           +  G   +H A  FGHV  ++ L   GA++ AQ  +  T LH+     +    + LL  G
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 307 ANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVP 345
           A  D  + +       A   G + + +++  +  S  +P
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 61/204 (29%), Positives = 93/204 (45%), Gaps = 11/204 (5%)

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
           +T +H    Q +   +  LL      D + + G TPL  +A      LC  LL H  A  
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG-ADA 421

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
              DE+GW  +H A + G       LL +GA + AQ   G T LH+ A  N E+ AR+L+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSG 363
            R A+ ++     +T   VA   G+  L +++ T + +++         A++R L  P  
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL-TSQGAEL--------DAQQRNLRTPLH 532

Query: 364 LASPRPLQRSASDINLKGEAQPAA 387
           LA  R   R+   + LK  A P A
Sbjct: 533 LAVERGKVRAIQHL-LKSGAVPDA 555



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 3/194 (1%)

Query: 131 VARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCA 190
           +  LL  G  P+  D  SG  PL  AA       + K+L   GA L+  T  G T +H A
Sbjct: 543 IQHLLKSGAVPDALD-QSGYGPLHTAAARGKYL-ICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 191 TRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENG 250
             + +   +  L +  A+     +   TPL+ +A  G +A+    LL   A     +++G
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVV-SALLQCGADPNAAEQSG 659

Query: 251 WQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRD 310
           W  +H A +      + +LL + A++ A+N  G T  H+ AL    +  +VL+  GA  D
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719

Query: 311 VRNYNSQTAFQVAI 324
           V++  S T  Q+A+
Sbjct: 720 VQDGVSCTPLQLAL 733



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 25/91 (27%), Positives = 38/91 (41%)

Query: 248 ENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGA 307
           EN    +H     G V+ +  LL +  D+  Q ASG T L I A   Q     +LL  GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 308 NRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
           + +  + +       A   G+   A ++  H
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDH 450


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 72/239 (30%), Positives = 113/239 (47%), Gaps = 36/239 (15%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   NF  P +G  PL +A++  N   ++++L + GA ++ +T+D LT +HCA R 
Sbjct: 258 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 315

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG--------- 244
            +      LLD GA    K   GL+P+ H A  G    C  LLL   A++          
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374

Query: 245 ---------------ITDE---------NGWQEIHQACRFGHVQHLEHLLFYGADMGAQN 280
                          + D+         NG+  +H AC+  HV+ +E LL  GA + A  
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434

Query: 281 ASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
            SG T LH+ +        + LL RGA+ +V N   +T   +A  AG+ E+A+ +  +K
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 67/242 (27%), Positives = 102/242 (42%), Gaps = 36/242 (14%)

Query: 126 HSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLT 185
           H   KV  LLDKG  PN    + G  PL +A +  N   ++++L   GA +D  T  GLT
Sbjct: 384 HRVAKV--LLDKGAKPNSRALN-GFTPLHIACK-KNHVRVMELLLKTGASIDAVTESGLT 439

Query: 186 AVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG------------------ 227
            +H A+   +   +  LL  GASP+  + +  TPL+ +A  G                  
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499

Query: 228 --------------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYG 273
                         G     +LLL ++A   +    G   +H A R GHV+ +  LL   
Sbjct: 500 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 559

Query: 274 ADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAE 333
           A        G T LH+ A Y +   A +LL R A+ +    N  T   VA+   N ++ +
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619

Query: 334 VI 335
           ++
Sbjct: 620 LL 621



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 70/264 (26%), Positives = 113/264 (42%), Gaps = 16/264 (6%)

Query: 81  LDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHS------TDKVARL 134
           ++TPL ++  R      A+ L+ +K       K N K   D   LH       T+ V  L
Sbjct: 470 VETPL-HMAARAGHTEVAKYLLQNK------AKVNAKAKDDQTPLHCAARIGHTNMVKLL 522

Query: 135 LDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQR 194
           L+   +PN     +G  PL +AA+  +   +L +L+   +     T+ G T +H A +  
Sbjct: 523 LENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYG 580

Query: 195 NAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEI 254
                  LL+  A P+     GLTPL H A+   +    +LLL           NG+  +
Sbjct: 581 KVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 639

Query: 255 HQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNY 314
           H A +   V+    LL YG    A++  G T LH+ A         +LL + AN ++ N 
Sbjct: 640 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 699

Query: 315 NSQTAFQVAIIAGNFELAEVIKTH 338
           +  T   +    G+  +A+V+  H
Sbjct: 700 SGLTPLHLVAQEGHVPVADVLIKH 723



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 65/259 (25%), Positives = 117/259 (45%), Gaps = 6/259 (2%)

Query: 83  TPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPN 142
           TPL ++  +Y +   A+ L++         K  L      V  ++ D V  LL +G  P 
Sbjct: 571 TPL-HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP- 628

Query: 143 FHDPD-SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTT 201
            H P  +G  PL +AA+  N  ++ + L   G   +  +  G+T +H A ++ +A  +  
Sbjct: 629 -HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 686

Query: 202 LLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFG 261
           LL   A+ +  +  GLTPL H     G     ++L+     +  T   G+  +H A  +G
Sbjct: 687 LLSKQANGNLGNKSGLTPL-HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 745

Query: 262 HVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
           +++ ++ LL + AD+ A+   G + LH  A         +LL  GA+ +  + +  T   
Sbjct: 746 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 805

Query: 322 VAIIAGNFELAEVIKTHKD 340
           +A   G   + +V+K   D
Sbjct: 806 IAKRLGYISVTDVLKVVTD 824



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 8/215 (3%)

Query: 125 LHSTDKVAR-LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           L   D+V R L++ G + N      G  PL +AAQ +N  +++K L   GA+ +  T DG
Sbjct: 120 LAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDG 177

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
            T +  A +Q +   +  L++ G     +      P  H A    D     +LL +    
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNP 232

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
            +  + G+  +H A  + ++   + LL  GA +     +G T LHI +        R+LL
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            RGA  + +  +  T    A   G+  ++E++  H
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 12/207 (5%)

Query: 135 LDKGLDPNFHDPDSGECP------LSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           LDK LD   +  D   C       L LA++  +   ++++L      L+  T+ G TA+H
Sbjct: 58  LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALH 116

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A        +  L++ GA+ + +  +G TPLY +A         + LL + A   +  E
Sbjct: 117 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQNVATE 175

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G+  +  A + GH   + HL+ Y    G +      ALHI A  +    A VLL    N
Sbjct: 176 DGFTPLAVALQQGHENVVAHLINY----GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 231

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVI 335
            DV +    T   +A    N  +A+++
Sbjct: 232 PDVLSKTGFTPLHIAAHYENLNVAQLL 258



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 42/147 (28%), Positives = 65/147 (44%), Gaps = 1/147 (0%)

Query: 182 DGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHA 241
           D  T+   A R  N       L  G   +  +  GL  L+ ++  G   +  ELL H   
Sbjct: 44  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKEI 102

Query: 242 QLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARV 301
            L  T + G   +H A   G  + +  L+ YGA++ AQ+  G T L++ A  N     + 
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162

Query: 302 LLFRGANRDVRNYNSQTAFQVAIIAGN 328
           LL  GAN++V   +  T   VA+  G+
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGH 189



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 35/102 (34%), Positives = 48/102 (47%), Gaps = 7/102 (6%)

Query: 239 DHAQLGIT----DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYN 294
           DH + G+     ++NG   +H A + GHV+ +  LL     +      GNTALHI AL  
Sbjct: 63  DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG 122

Query: 295 QESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
           Q+   R L+  GAN    N  SQ  F    +A      EV+K
Sbjct: 123 QDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLEVVK 161


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 72/239 (30%), Positives = 113/239 (47%), Gaps = 36/239 (15%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   NF  P +G  PL +A++  N   ++++L + GA ++ +T+D LT +HCA R 
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG--------- 244
            +      LLD GA    K   GL+P+ H A  G    C  LLL   A++          
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 245 ---------------ITDE---------NGWQEIHQACRFGHVQHLEHLLFYGADMGAQN 280
                          + D+         NG+  +H AC+  HV+ +E LL  GA + A  
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 281 ASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
            SG T LH+ +        + LL RGA+ +V N   +T   +A  AG+ E+A+ +  +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 67/242 (27%), Positives = 102/242 (42%), Gaps = 36/242 (14%)

Query: 126 HSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLT 185
           H   KV  LLDKG  PN    + G  PL +A +  N   ++++L   GA +D  T  GLT
Sbjct: 351 HRVAKV--LLDKGAKPNSRALN-GFTPLHIACK-KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 186 AVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG------------------ 227
            +H A+   +   +  LL  GASP+  + +  TPL+ +A  G                  
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466

Query: 228 --------------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYG 273
                         G     +LLL ++A   +    G   +H A R GHV+ +  LL   
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 274 ADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAE 333
           A        G T LH+ A Y +   A +LL R A+ +    N  T   VA+   N ++ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 334 VI 335
           ++
Sbjct: 587 LL 588



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 70/264 (26%), Positives = 113/264 (42%), Gaps = 16/264 (6%)

Query: 81  LDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHS------TDKVARL 134
           ++TPL ++  R      A+ L+ +K       K N K   D   LH       T+ V  L
Sbjct: 437 VETPL-HMAARAGHTEVAKYLLQNK------AKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 135 LDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQR 194
           L+   +PN     +G  PL +AA+  +   +L +L+   +     T+ G T +H A +  
Sbjct: 490 LENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYG 547

Query: 195 NAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEI 254
                  LL+  A P+     GLTPL H A+   +    +LLL           NG+  +
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 255 HQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNY 314
           H A +   V+    LL YG    A++  G T LH+ A         +LL + AN ++ N 
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666

Query: 315 NSQTAFQVAIIAGNFELAEVIKTH 338
           +  T   +    G+  +A+V+  H
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKH 690



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 65/259 (25%), Positives = 117/259 (45%), Gaps = 6/259 (2%)

Query: 83  TPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPN 142
           TPL ++  +Y +   A+ L++         K  L      V  ++ D V  LL +G  P 
Sbjct: 538 TPL-HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP- 595

Query: 143 FHDPD-SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTT 201
            H P  +G  PL +AA+  N  ++ + L   G   +  +  G+T +H A ++ +A  +  
Sbjct: 596 -HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653

Query: 202 LLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFG 261
           LL   A+ +  +  GLTPL H     G     ++L+     +  T   G+  +H A  +G
Sbjct: 654 LLSKQANGNLGNKSGLTPL-HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 262 HVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
           +++ ++ LL + AD+ A+   G + LH  A         +LL  GA+ +  + +  T   
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 322 VAIIAGNFELAEVIKTHKD 340
           +A   G   + +V+K   D
Sbjct: 773 IAKRLGYISVTDVLKVVTD 791



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 8/215 (3%)

Query: 125 LHSTDKVAR-LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           L   D+V R L++ G + N      G  PL +AAQ +N  +++K L   GA+ +  T DG
Sbjct: 87  LAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDG 144

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
            T +  A +Q +   +  L++ G     +      P  H A    D     +LL +    
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
            +  + G+  +H A  + ++   + LL  GA +     +G T LHI +        R+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            RGA  + +  +  T    A   G+  ++E++  H
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 12/207 (5%)

Query: 135 LDKGLDPNFHDPDSGECP------LSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           LDK LD   +  D   C       L LA++  +   ++++L      L+  T+ G TA+H
Sbjct: 25  LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALH 83

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A        +  L++ GA+ + +  +G TPLY +A         + LL + A   +  E
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQNVATE 142

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G+  +  A + GH   + HL+ Y    G +      ALHI A  +    A VLL    N
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINY----GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVI 335
            DV +    T   +A    N  +A+++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLL 225



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 1/151 (0%)

Query: 178 FRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLL 237
           FR  D  T+   A R  N       L  G   +  +  GL  L+ ++  G   +  ELL 
Sbjct: 7   FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL- 65

Query: 238 HDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQES 297
           H    L  T + G   +H A   G  + +  L+ YGA++ AQ+  G T L++ A  N   
Sbjct: 66  HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125

Query: 298 CARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
             + LL  GAN++V   +  T   VA+  G+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGH 156



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 35/102 (34%), Positives = 48/102 (47%), Gaps = 7/102 (6%)

Query: 239 DHAQLGIT----DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYN 294
           DH + G+     ++NG   +H A + GHV+ +  LL     +      GNTALHI AL  
Sbjct: 30  DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG 89

Query: 295 QESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
           Q+   R L+  GAN    N  SQ  F    +A      EV+K
Sbjct: 90  QDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLEVVK 128


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 72/239 (30%), Positives = 113/239 (47%), Gaps = 36/239 (15%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   NF  P +G  PL +A++  N   ++++L + GA ++ +T+D LT +HCA R 
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG--------- 244
            +      LLD GA    K   GL+P+ H A  G    C  LLL   A++          
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 245 ---------------ITDE---------NGWQEIHQACRFGHVQHLEHLLFYGADMGAQN 280
                          + D+         NG+  +H AC+  HV+ +E LL  GA + A  
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 281 ASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
            SG T LH+ +        + LL RGA+ +V N   +T   +A  AG+ E+A+ +  +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 67/242 (27%), Positives = 102/242 (42%), Gaps = 36/242 (14%)

Query: 126 HSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLT 185
           H   KV  LLDKG  PN    + G  PL +A +  N   ++++L   GA +D  T  GLT
Sbjct: 351 HRVAKV--LLDKGAKPNSRALN-GFTPLHIACK-KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 186 AVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG------------------ 227
            +H A+   +   +  LL  GASP+  + +  TPL+ +A  G                  
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466

Query: 228 --------------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYG 273
                         G     +LLL ++A   +    G   +H A R GHV+ +  LL   
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 274 ADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAE 333
           A        G T LH+ A Y +   A +LL R A+ +    N  T   VA+   N ++ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 334 VI 335
           ++
Sbjct: 587 LL 588



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 70/264 (26%), Positives = 113/264 (42%), Gaps = 16/264 (6%)

Query: 81  LDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHS------TDKVARL 134
           ++TPL ++  R      A+ L+ +K       K N K   D   LH       T+ V  L
Sbjct: 437 VETPL-HMAARAGHTEVAKYLLQNK------AKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 135 LDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQR 194
           L+   +PN     +G  PL +AA+  +   +L +L+   +     T+ G T +H A +  
Sbjct: 490 LENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYG 547

Query: 195 NAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEI 254
                  LL+  A P+     GLTPL H A+   +    +LLL           NG+  +
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 255 HQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNY 314
           H A +   V+    LL YG    A++  G T LH+ A         +LL + AN ++ N 
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666

Query: 315 NSQTAFQVAIIAGNFELAEVIKTH 338
           +  T   +    G+  +A+V+  H
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKH 690



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 65/259 (25%), Positives = 117/259 (45%), Gaps = 6/259 (2%)

Query: 83  TPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPN 142
           TPL ++  +Y +   A+ L++         K  L      V  ++ D V  LL +G  P 
Sbjct: 538 TPL-HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP- 595

Query: 143 FHDPD-SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTT 201
            H P  +G  PL +AA+  N  ++ + L   G   +  +  G+T +H A ++ +A  +  
Sbjct: 596 -HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653

Query: 202 LLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFG 261
           LL   A+ +  +  GLTPL H     G     ++L+     +  T   G+  +H A  +G
Sbjct: 654 LLSKQANGNLGNKSGLTPL-HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 262 HVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
           +++ ++ LL + AD+ A+   G + LH  A         +LL  GA+ +  + +  T   
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 322 VAIIAGNFELAEVIKTHKD 340
           +A   G   + +V+K   D
Sbjct: 773 IAKRLGYISVTDVLKVVTD 791



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 8/215 (3%)

Query: 125 LHSTDKVAR-LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           L   D+V R L++ G + N      G  PL +AAQ +N  +++K L   GA+ +  T DG
Sbjct: 87  LAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDG 144

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
            T +  A +Q +   +  L++ G     +      P  H A    D     +LL +    
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
            +  + G+  +H A  + ++   + LL  GA +     +G T LHI +        R+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            RGA  + +  +  T    A   G+  ++E++  H
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 12/207 (5%)

Query: 135 LDKGLDPNFHDPDSGECP------LSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           LDK LD   +  D   C       L LA++  +   ++++L      L+  T+ G TA+H
Sbjct: 25  LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALH 83

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A        +  L++ GA+ + +  +G TPLY +A         + LL + A   +  E
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQNVATE 142

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G+  +  A + GH   + HL+ Y    G +      ALHI A  +    A VLL    N
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINY----GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVI 335
            DV +    T   +A    N  +A+++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLL 225



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 1/151 (0%)

Query: 178 FRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLL 237
           FR  D  T+   A R  N       L  G   +  +  GL  L+ ++  G   +  ELL 
Sbjct: 7   FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL- 65

Query: 238 HDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQES 297
           H    L  T + G   +H A   G  + +  L+ YGA++ AQ+  G T L++ A  N   
Sbjct: 66  HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125

Query: 298 CARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
             + LL  GAN++V   +  T   VA+  G+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGH 156



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 35/102 (34%), Positives = 48/102 (47%), Gaps = 7/102 (6%)

Query: 239 DHAQLGIT----DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYN 294
           DH + G+     ++NG   +H A + GHV+ +  LL     +      GNTALHI AL  
Sbjct: 30  DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG 89

Query: 295 QESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
           Q+   R L+  GAN    N  SQ  F    +A      EV+K
Sbjct: 90  QDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLEVVK 128


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 72/239 (30%), Positives = 113/239 (47%), Gaps = 36/239 (15%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   NF  P +G  PL +A++  N   ++++L + GA ++ +T+D LT +HCA R 
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG--------- 244
            +      LLD GA    K   GL+P+ H A  G    C  LLL   A++          
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 245 ---------------ITDE---------NGWQEIHQACRFGHVQHLEHLLFYGADMGAQN 280
                          + D+         NG+  +H AC+  HV+ +E LL  GA + A  
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 281 ASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
            SG T LH+ +        + LL RGA+ +V N   +T   +A  AG+ E+A+ +  +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 67/242 (27%), Positives = 102/242 (42%), Gaps = 36/242 (14%)

Query: 126 HSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLT 185
           H   KV  LLDKG  PN    + G  PL +A +  N   ++++L   GA +D  T  GLT
Sbjct: 351 HRVAKV--LLDKGAKPNSRALN-GFTPLHIACK-KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 186 AVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG------------------ 227
            +H A+   +   +  LL  GASP+  + +  TPL+ +A  G                  
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466

Query: 228 --------------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYG 273
                         G     +LLL ++A   +    G   +H A R GHV+ +  LL   
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 274 ADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAE 333
           A        G T LH+ A Y +   A +LL R A+ +    N  T   VA+   N ++ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 334 VI 335
           ++
Sbjct: 587 LL 588



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 70/264 (26%), Positives = 113/264 (42%), Gaps = 16/264 (6%)

Query: 81  LDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHS------TDKVARL 134
           ++TPL ++  R      A+ L+ +K       K N K   D   LH       T+ V  L
Sbjct: 437 VETPL-HMAARAGHTEVAKYLLQNK------AKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 135 LDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQR 194
           L+   +PN     +G  PL +AA+  +   +L +L+   +     T+ G T +H A +  
Sbjct: 490 LENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYG 547

Query: 195 NAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEI 254
                  LL+  A P+     GLTPL H A+   +    +LLL           NG+  +
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 255 HQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNY 314
           H A +   V+    LL YG    A++  G T LH+ A         +LL + AN ++ N 
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666

Query: 315 NSQTAFQVAIIAGNFELAEVIKTH 338
           +  T   +    G+  +A+V+  H
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKH 690



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 65/259 (25%), Positives = 117/259 (45%), Gaps = 6/259 (2%)

Query: 83  TPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPN 142
           TPL ++  +Y +   A+ L++         K  L      V  ++ D V  LL +G  P 
Sbjct: 538 TPL-HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP- 595

Query: 143 FHDPD-SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTT 201
            H P  +G  PL +AA+  N  ++ + L   G   +  +  G+T +H A ++ +A  +  
Sbjct: 596 -HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653

Query: 202 LLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFG 261
           LL   A+ +  +  GLTPL H     G     ++L+     +  T   G+  +H A  +G
Sbjct: 654 LLSKQANGNLGNKSGLTPL-HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 262 HVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
           +++ ++ LL + AD+ A+   G + LH  A         +LL  GA+ +  + +  T   
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 322 VAIIAGNFELAEVIKTHKD 340
           +A   G   + +V+K   D
Sbjct: 773 IAKRLGYISVTDVLKVVTD 791



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 8/215 (3%)

Query: 125 LHSTDKVAR-LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           L   D+V R L++ G + N      G  PL +AAQ +N  +++K L   GA+ +  T DG
Sbjct: 87  LAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDG 144

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
            T +  A +Q +   +  L++ G     +      P  H A    D     +LL +    
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
            +  + G+  +H A  + ++   + LL  GA +     +G T LHI +        R+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            RGA  + +  +  T    A   G+  ++E++  H
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 12/207 (5%)

Query: 135 LDKGLDPNFHDPDSGECP------LSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           LDK LD   +  D   C       L LA++  +   ++++L      L+  T+ G TA+H
Sbjct: 25  LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALH 83

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A        +  L++ GA+ + +  +G TPLY +A         + LL + A   +  E
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQNVATE 142

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G+  +  A + GH   + HL+ Y    G +      ALHI A  +    A VLL    N
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINY----GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVI 335
            DV +    T   +A    N  +A+++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLL 225



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 1/151 (0%)

Query: 178 FRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLL 237
           FR  D  T+   A R  N       L  G   +  +  GL  L+ ++  G   +  ELL 
Sbjct: 7   FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL- 65

Query: 238 HDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQES 297
           H    L  T + G   +H A   G  + +  L+ YGA++ AQ+  G T L++ A  N   
Sbjct: 66  HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125

Query: 298 CARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
             + LL  GAN++V   +  T   VA+  G+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGH 156



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 35/102 (34%), Positives = 48/102 (47%), Gaps = 7/102 (6%)

Query: 239 DHAQLGIT----DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYN 294
           DH + G+     ++NG   +H A + GHV+ +  LL     +      GNTALHI AL  
Sbjct: 30  DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG 89

Query: 295 QESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
           Q+   R L+  GAN    N  SQ  F    +A      EV+K
Sbjct: 90  QDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLEVVK 128


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 72/239 (30%), Positives = 113/239 (47%), Gaps = 36/239 (15%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   NF  P +G  PL +A++  N   ++++L + GA ++ +T+D LT +HCA R 
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG--------- 244
            +      LLD GA    K   GL+P+ H A  G    C  LLL   A++          
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 245 ---------------ITDE---------NGWQEIHQACRFGHVQHLEHLLFYGADMGAQN 280
                          + D+         NG+  +H AC+  HV+ +E LL  GA + A  
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 281 ASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
            SG T LH+ +        + LL RGA+ +V N   +T   +A  AG+ E+A+ +  +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 67/242 (27%), Positives = 102/242 (42%), Gaps = 36/242 (14%)

Query: 126 HSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLT 185
           H   KV  LLDKG  PN    + G  PL +A +  N   ++++L   GA +D  T  GLT
Sbjct: 351 HRVAKV--LLDKGAKPNSRALN-GFTPLHIACK-KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 186 AVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG------------------ 227
            +H A+   +   +  LL  GASP+  + +  TPL+ +A  G                  
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466

Query: 228 --------------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYG 273
                         G     +LLL ++A   +    G   +H A R GHV+ +  LL   
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 274 ADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAE 333
           A        G T LH+ A Y +   A +LL R A+ +    N  T   VA+   N ++ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 334 VI 335
           ++
Sbjct: 587 LL 588



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 70/264 (26%), Positives = 113/264 (42%), Gaps = 16/264 (6%)

Query: 81  LDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHS------TDKVARL 134
           ++TPL ++  R      A+ L+ +K       K N K   D   LH       T+ V  L
Sbjct: 437 VETPL-HMAARAGHTEVAKYLLQNK------AKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 135 LDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQR 194
           L+   +PN     +G  PL +AA+  +   +L +L+   +     T+ G T +H A +  
Sbjct: 490 LENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYG 547

Query: 195 NAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEI 254
                  LL+  A P+     GLTPL H A+   +    +LLL           NG+  +
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606

Query: 255 HQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNY 314
           H A +   V+    LL YG    A++  G T LH+ A         +LL + AN ++ N 
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666

Query: 315 NSQTAFQVAIIAGNFELAEVIKTH 338
           +  T   +    G+  +A+V+  H
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKH 690



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 65/259 (25%), Positives = 117/259 (45%), Gaps = 6/259 (2%)

Query: 83  TPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPN 142
           TPL ++  +Y +   A+ L++         K  L      V  ++ D V  LL +G  P 
Sbjct: 538 TPL-HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP- 595

Query: 143 FHDPD-SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTT 201
            H P  +G  PL +AA+  N  ++ + L   G   +  +  G+T +H A ++ +A  +  
Sbjct: 596 -HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653

Query: 202 LLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFG 261
           LL   A+ +  +  GLTPL H     G     ++L+     +  T   G+  +H A  +G
Sbjct: 654 LLSKQANGNLGNKSGLTPL-HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712

Query: 262 HVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
           +++ ++ LL + AD+ A+   G + LH  A         +LL  GA+ +  + +  T   
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 322 VAIIAGNFELAEVIKTHKD 340
           +A   G   + +V+K   D
Sbjct: 773 IAKRLGYISVTDVLKVVTD 791



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 8/215 (3%)

Query: 125 LHSTDKVAR-LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           L   D+V R L++ G + N      G  PL +AAQ +N  +++K L   GA+ +  T DG
Sbjct: 87  LAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDG 144

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
            T +  A +Q +   +  L++ G     +      P  H A    D     +LL +    
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
            +  + G+  +H A  + ++   + LL  GA +     +G T LHI +        R+LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            RGA  + +  +  T    A   G+  ++E++  H
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 12/207 (5%)

Query: 135 LDKGLDPNFHDPDSGECP------LSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           LDK LD   +  D   C       L LA++  +   ++++L      L+  T+ G TA+H
Sbjct: 25  LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALH 83

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A        +  L++ GA+ + +  +G TPLY +A         + LL + A   +  E
Sbjct: 84  IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQNVATE 142

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G+  +  A + GH   + HL+ Y    G +      ALHI A  +    A VLL    N
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINY----GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVI 335
            DV +    T   +A    N  +A+++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLL 225



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 1/151 (0%)

Query: 178 FRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLL 237
           FR  D  T+   A R  N       L  G   +  +  GL  L+ ++  G   +  ELL 
Sbjct: 7   FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL- 65

Query: 238 HDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQES 297
           H    L  T + G   +H A   G  + +  L+ YGA++ AQ+  G T L++ A  N   
Sbjct: 66  HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125

Query: 298 CARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
             + LL  GAN++V   +  T   VA+  G+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGH 156



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 35/102 (34%), Positives = 48/102 (47%), Gaps = 7/102 (6%)

Query: 239 DHAQLGIT----DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYN 294
           DH + G+     ++NG   +H A + GHV+ +  LL     +      GNTALHI AL  
Sbjct: 30  DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG 89

Query: 295 QESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
           Q+   R L+  GAN    N  SQ  F    +A      EV+K
Sbjct: 90  QDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLEVVK 128


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 63/189 (33%), Positives = 97/189 (51%), Gaps = 2/189 (1%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLG 206
           +SG  PL +AA   N  ++  +L N GA +DF  R+G+T +H A+++ N   +  LLD G
Sbjct: 210 ESGFTPLHIAAHYGNV-NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268

Query: 207 ASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHL 266
              D K   GLTPL+ +A  G D +  ELLL   A L    +NG   +H A +  HV+ +
Sbjct: 269 GQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 327

Query: 267 EHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIA 326
           +HLL + A +        TALH+ A        ++LL + AN + R  N  T   +A   
Sbjct: 328 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 387

Query: 327 GNFELAEVI 335
              ++ E++
Sbjct: 388 NRIKVMELL 396



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/234 (29%), Positives = 108/234 (46%), Gaps = 34/234 (14%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   +F    +G  PL +A++  N T+++K+L + G  +D +TRDGLT +HCA R 
Sbjct: 231 LLNRGAAVDF-TARNGITPLHVASKRGN-TNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG-------------------------- 227
            +   +  LL+ GA    +   GL+PL+ +A G                           
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTAL 348

Query: 228 ------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNA 281
                 G     +LLL   A       NG+  +H AC+   ++ +E L+ YGA + A   
Sbjct: 349 HVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 408

Query: 282 SGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           SG T +H+ A     +   +LL  GA+ DV N   +TA  +A  AG  E+   +
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462



 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 70/210 (33%), Positives = 94/210 (44%), Gaps = 2/210 (0%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D+V  LL +   P      +G  PL +AAQ D+  + +K L    A +D  T D LTA+H
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV-ECVKHLLQHKAPVDDVTLDYLTALH 349

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A    +      LLD  A+P+ +   G TPL H A         ELL+   A +    E
Sbjct: 350 VAAHCGHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITE 408

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G   IH A   GH+  +  LL  GA     N  G TALH+ A   Q    R LL  GA 
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            D R    QT   +A   G  E+ +++  H
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQH 498



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 63/212 (29%), Positives = 98/212 (46%), Gaps = 4/212 (1%)

Query: 126 HSTDKVARLL-DKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGL 184
           +   KVA LL +KG  P+     +G  PL +AA+  N   +   L N GA  +  T+ G+
Sbjct: 585 YDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGV 642

Query: 185 TAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG 244
           T +H A+++ +   +T LLD GA+       GLT L H A         ++L    A   
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQD 701

Query: 245 ITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLF 304
              + G+  +  AC +G+V+ +  LL  GA++ A+  +G T LH  A         VLL 
Sbjct: 702 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761

Query: 305 RGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
            GA  +    N  TA  +A   G   + + +K
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVDTLK 793



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 63/202 (31%), Positives = 91/202 (45%), Gaps = 3/202 (1%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LLDK  +PN    + G  PL +A +  N   ++++L   GA +   T  GLT +H A   
Sbjct: 363 LLDKRANPNARALN-GFTPLHIACK-KNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQE 253
            +   +  LL  GASPD  + RG T L H A   G       LL + A +          
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETAL-HMAARAGQVEVVRCLLRNGALVDARAREEQTP 479

Query: 254 IHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRN 313
           +H A R G  + ++ LL + A   A   +G T LHI A   Q   A VLL  GA   +  
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 539

Query: 314 YNSQTAFQVAIIAGNFELAEVI 335
               T   VA   G+ ++A+++
Sbjct: 540 KKGFTPLHVAAKYGSLDVAKLL 561



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 12/241 (4%)

Query: 98  AQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAA 157
           A +L   K F  LH  A           + +  VA+LL +          +G  PL +AA
Sbjct: 534 AHSLATKKGFTPLHVAAK----------YGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583

Query: 158 QLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGL 217
             DN    L +L+ G A      ++G T +H A ++      +TLL+ GA  +    +G+
Sbjct: 584 HYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 642

Query: 218 TPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMG 277
           TPL H A   G      LLL   A + ++ ++G   +H A +   V   + L  +GAD  
Sbjct: 643 TPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701

Query: 278 AQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKT 337
           A    G T L +   Y        LL +GAN + +  N  T    A   G+  +  V+  
Sbjct: 702 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761

Query: 338 H 338
           H
Sbjct: 762 H 762



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 53/191 (27%), Positives = 83/191 (43%), Gaps = 2/191 (1%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           +G  PL ++A+ +   D+  VL   GA     T+ G T +H A +  +      LL   A
Sbjct: 508 NGYTPLHISAR-EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566

Query: 208 SPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLE 267
           + D     GLTPL H A    +     LLL   A    T +NG+  +H A +   +Q   
Sbjct: 567 AADSAGKNGLTPL-HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625

Query: 268 HLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAG 327
            LL YGA+       G T LH+ +         +LL +GAN  +   +  T+  +A    
Sbjct: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685

Query: 328 NFELAEVIKTH 338
              +A+++  H
Sbjct: 686 KVNVADILTKH 696



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 60/186 (32%), Positives = 80/186 (43%), Gaps = 2/186 (1%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLG 206
           +SG  P+ +AA + +   +L +L+NG A  D     G TA+H A R      +  LL  G
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466

Query: 207 ASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHL 266
           A  D +     TPL H A   G     +LLL   A       NG+  +H + R G V   
Sbjct: 467 ALVDARAREEQTPL-HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525

Query: 267 EHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIA 326
             LL  GA        G T LH+ A Y     A++LL R A  D    N  T   VA   
Sbjct: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585

Query: 327 GNFELA 332
            N ++A
Sbjct: 586 DNQKVA 591



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/169 (27%), Positives = 79/169 (46%), Gaps = 1/169 (0%)

Query: 167 KVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALG 226
           K+L +  A+ + R  +G T +H A ++     +  L+  GAS       GLTP++ +A  
Sbjct: 361 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420

Query: 227 GGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTA 286
           G   +   LLL + A   +T+  G   +H A R G V+ +  LL  GA + A+     T 
Sbjct: 421 GHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 479

Query: 287 LHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           LHI +   +    ++LL   A+ D    N  T   ++   G  ++A V+
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 60/224 (26%), Positives = 95/224 (42%), Gaps = 15/224 (6%)

Query: 124 QLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           Q +  D V  LL+ G + +    D G  PL++A Q  +   +  +L+N     D + +  
Sbjct: 118 QENHIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLEN-----DTKGKVR 171

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSR--------GLTPLYHSALGGGDALCCEL 235
           L A+H A R+ +  +   LL    + D +           G TPL H A   G+     L
Sbjct: 172 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL-HIAAHYGNVNVATL 230

Query: 236 LLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQ 295
           LL+  A +  T  NG   +H A + G+   ++ LL  G  + A+   G T LH  A    
Sbjct: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290

Query: 296 ESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
           +    +LL RGA    R  N  +   +A    + E  + +  HK
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 40/254 (15%)

Query: 119 FMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDF 178
           F+   +  + DKV   L  G+D N  +  +G   L LAA+ +    L++ L   G+ +D 
Sbjct: 14  FLRAARAGNLDKVVEYLKGGIDINTCN-QNGLNALHLAAK-EGHVGLVQELLGRGSSVDS 71

Query: 179 RTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLH 238
            T+ G TA+H A+    A  +  L+  GA+ + +   G TPLY +A      +  + LL 
Sbjct: 72  ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLE 130

Query: 239 DHAQLGITDENGWQEIHQACRFGHVQHLEHLL---------------------------- 270
           + A      E+G+  +  A + GH Q +  LL                            
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 190

Query: 271 ---FYGADMGAQ------NASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
               + AD+ ++        SG T LHI A Y   + A +LL RGA  D    N  T   
Sbjct: 191 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 250

Query: 322 VAIIAGNFELAEVI 335
           VA   GN  + +++
Sbjct: 251 VASKRGNTNMVKLL 264


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 63/189 (33%), Positives = 97/189 (51%), Gaps = 2/189 (1%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLG 206
           +SG  PL +AA   N  ++  +L N GA +DF  R+G+T +H A+++ N   +  LLD G
Sbjct: 231 ESGFTPLHIAAHYGNV-NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289

Query: 207 ASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHL 266
              D K   GLTPL+ +A  G D +  ELLL   A L    +NG   +H A +  HV+ +
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348

Query: 267 EHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIA 326
           +HLL + A +        TALH+ A        ++LL + AN + R  N  T   +A   
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408

Query: 327 GNFELAEVI 335
              ++ E++
Sbjct: 409 NRIKVMELL 417



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/234 (29%), Positives = 108/234 (46%), Gaps = 34/234 (14%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   +F    +G  PL +A++  N T+++K+L + G  +D +TRDGLT +HCA R 
Sbjct: 252 LLNRGAAVDF-TARNGITPLHVASKRGN-TNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG-------------------------- 227
            +   +  LL+ GA    +   GL+PL+ +A G                           
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTAL 369

Query: 228 ------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNA 281
                 G     +LLL   A       NG+  +H AC+   ++ +E L+ YGA + A   
Sbjct: 370 HVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429

Query: 282 SGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           SG T +H+ A     +   +LL  GA+ DV N   +TA  +A  AG  E+   +
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483



 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 70/210 (33%), Positives = 94/210 (44%), Gaps = 2/210 (0%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D+V  LL +   P      +G  PL +AAQ D+  + +K L    A +D  T D LTA+H
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV-ECVKHLLQHKAPVDDVTLDYLTALH 370

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A    +      LLD  A+P+ +   G TPL H A         ELL+   A +    E
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITE 429

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G   IH A   GH+  +  LL  GA     N  G TALH+ A   Q    R LL  GA 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            D R    QT   +A   G  E+ +++  H
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQH 519



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 63/212 (29%), Positives = 98/212 (46%), Gaps = 4/212 (1%)

Query: 126 HSTDKVARLL-DKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGL 184
           +   KVA LL +KG  P+     +G  PL +AA+  N   +   L N GA  +  T+ G+
Sbjct: 606 YDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGV 663

Query: 185 TAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG 244
           T +H A+++ +   +T LLD GA+       GLT L H A         ++L    A   
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQD 722

Query: 245 ITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLF 304
              + G+  +  AC +G+V+ +  LL  GA++ A+  +G T LH  A         VLL 
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782

Query: 305 RGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
            GA  +    N  TA  +A   G   + + +K
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTLK 814



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 63/202 (31%), Positives = 91/202 (45%), Gaps = 3/202 (1%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LLDK  +PN    + G  PL +A +  N   ++++L   GA +   T  GLT +H A   
Sbjct: 384 LLDKRANPNARALN-GFTPLHIACK-KNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQE 253
            +   +  LL  GASPD  + RG T L H A   G       LL + A +          
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETAL-HMAARAGQVEVVRCLLRNGALVDARAREEQTP 500

Query: 254 IHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRN 313
           +H A R G  + ++ LL + A   A   +G T LHI A   Q   A VLL  GA   +  
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560

Query: 314 YNSQTAFQVAIIAGNFELAEVI 335
               T   VA   G+ ++A+++
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLL 582



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 12/241 (4%)

Query: 98  AQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAA 157
           A +L   K F  LH  A           + +  VA+LL +          +G  PL +AA
Sbjct: 555 AHSLATKKGFTPLHVAAK----------YGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604

Query: 158 QLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGL 217
             DN    L +L+ G A      ++G T +H A ++      +TLL+ GA  +    +G+
Sbjct: 605 HYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663

Query: 218 TPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMG 277
           TPL H A   G      LLL   A + ++ ++G   +H A +   V   + L  +GAD  
Sbjct: 664 TPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722

Query: 278 AQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKT 337
           A    G T L +   Y        LL +GAN + +  N  T    A   G+  +  V+  
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782

Query: 338 H 338
           H
Sbjct: 783 H 783



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 53/191 (27%), Positives = 83/191 (43%), Gaps = 2/191 (1%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           +G  PL ++A+ +   D+  VL   GA     T+ G T +H A +  +      LL   A
Sbjct: 529 NGYTPLHISAR-EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587

Query: 208 SPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLE 267
           + D     GLTPL H A    +     LLL   A    T +NG+  +H A +   +Q   
Sbjct: 588 AADSAGKNGLTPL-HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646

Query: 268 HLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAG 327
            LL YGA+       G T LH+ +         +LL +GAN  +   +  T+  +A    
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706

Query: 328 NFELAEVIKTH 338
              +A+++  H
Sbjct: 707 KVNVADILTKH 717



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 60/186 (32%), Positives = 80/186 (43%), Gaps = 2/186 (1%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLG 206
           +SG  P+ +AA + +   +L +L+NG A  D     G TA+H A R      +  LL  G
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 207 ASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHL 266
           A  D +     TPL H A   G     +LLL   A       NG+  +H + R G V   
Sbjct: 488 ALVDARAREEQTPL-HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546

Query: 267 EHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIA 326
             LL  GA        G T LH+ A Y     A++LL R A  D    N  T   VA   
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606

Query: 327 GNFELA 332
            N ++A
Sbjct: 607 DNQKVA 612



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/169 (27%), Positives = 79/169 (46%), Gaps = 1/169 (0%)

Query: 167 KVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALG 226
           K+L +  A+ + R  +G T +H A ++     +  L+  GAS       GLTP++ +A  
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 227 GGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTA 286
           G   +   LLL + A   +T+  G   +H A R G V+ +  LL  GA + A+     T 
Sbjct: 442 GHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500

Query: 287 LHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           LHI +   +    ++LL   A+ D    N  T   ++   G  ++A V+
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 60/224 (26%), Positives = 95/224 (42%), Gaps = 15/224 (6%)

Query: 124 QLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           Q +  D V  LL+ G + +    D G  PL++A Q  +   +  +L+N     D + +  
Sbjct: 139 QENHIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLEN-----DTKGKVR 192

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSR--------GLTPLYHSALGGGDALCCEL 235
           L A+H A R+ +  +   LL    + D +           G TPL H A   G+     L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL-HIAAHYGNVNVATL 251

Query: 236 LLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQ 295
           LL+  A +  T  NG   +H A + G+   ++ LL  G  + A+   G T LH  A    
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 296 ESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
           +    +LL RGA    R  N  +   +A    + E  + +  HK
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 40/254 (15%)

Query: 119 FMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDF 178
           F+   +  + DKV   L  G+D N  +  +G   L LAA+ +    L++ L   G+ +D 
Sbjct: 35  FLRAARAGNLDKVVEYLKGGIDINTCN-QNGLNALHLAAK-EGHVGLVQELLGRGSSVDS 92

Query: 179 RTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLH 238
            T+ G TA+H A+    A  +  L+  GA+ + +   G TPLY +A      +  + LL 
Sbjct: 93  ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLE 151

Query: 239 DHAQLGITDENGWQEIHQACRFGHVQHLEHLL---------------------------- 270
           + A      E+G+  +  A + GH Q +  LL                            
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 271 ---FYGADMGAQ------NASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
               + AD+ ++        SG T LHI A Y   + A +LL RGA  D    N  T   
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 271

Query: 322 VAIIAGNFELAEVI 335
           VA   GN  + +++
Sbjct: 272 VASKRGNTNMVKLL 285


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 94.7 bits (234), Expect = 7e-19
 Identities = 63/189 (33%), Positives = 97/189 (51%), Gaps = 2/189 (1%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLG 206
           +SG  PL +AA   N  ++  +L N GA +DF  R+G+T +H A+++ N   +  LLD G
Sbjct: 231 ESGFTPLHIAAHYGNV-NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289

Query: 207 ASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHL 266
              D K   GLTPL+ +A  G D +  ELLL   A L    +NG   +H A +  HV+ +
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348

Query: 267 EHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIA 326
           +HLL + A +        TALH+ A        ++LL + AN + R  N  T   +A   
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408

Query: 327 GNFELAEVI 335
              ++ E++
Sbjct: 409 NRIKVMELL 417



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/234 (29%), Positives = 108/234 (46%), Gaps = 34/234 (14%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL++G   +F    +G  PL +A++  N T+++K+L + G  +D +TRDGLT +HCA R 
Sbjct: 252 LLNRGAAVDF-TARNGITPLHVASKRGN-TNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG-------------------------- 227
            +   +  LL+ GA    +   GL+PL+ +A G                           
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTAL 369

Query: 228 ------GDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNA 281
                 G     +LLL   A       NG+  +H AC+   ++ +E L+ YGA + A   
Sbjct: 370 HVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429

Query: 282 SGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           SG T +H+ A     +   +LL  GA+ DV N   +TA  +A  AG  E+   +
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483



 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 70/210 (33%), Positives = 94/210 (44%), Gaps = 2/210 (0%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D+V  LL +   P      +G  PL +AAQ D+  + +K L    A +D  T D LTA+H
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV-ECVKHLLQHKAPVDDVTLDYLTALH 370

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A    +      LLD  A+P+ +   G TPL H A         ELL+   A +    E
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITE 429

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G   IH A   GH+  +  LL  GA     N  G TALH+ A   Q    R LL  GA 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
            D R    QT   +A   G  E+ +++  H
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQH 519



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 63/212 (29%), Positives = 98/212 (46%), Gaps = 4/212 (1%)

Query: 126 HSTDKVARLL-DKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGL 184
           +   KVA LL +KG  P+     +G  PL +AA+  N   +   L N GA  +  T+ G+
Sbjct: 606 YDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGV 663

Query: 185 TAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG 244
           T +H A+++ +   +T LLD GA+       GLT L H A         ++L    A   
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQD 722

Query: 245 ITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLF 304
              + G+  +  AC +G+V+ +  LL  GA++ A+  +G T LH  A         VLL 
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782

Query: 305 RGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
            GA  +    N  TA  +A   G   + + +K
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTLK 814



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 63/202 (31%), Positives = 91/202 (45%), Gaps = 3/202 (1%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LLDK  +PN    + G  PL +A +  N   ++++L   GA +   T  GLT +H A   
Sbjct: 384 LLDKRANPNARALN-GFTPLHIACK-KNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQE 253
            +   +  LL  GASPD  + RG T L H A   G       LL + A +          
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETAL-HMAARAGQVEVVRCLLRNGALVDARAREEQTP 500

Query: 254 IHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRN 313
           +H A R G  + ++ LL + A   A   +G T LHI A   Q   A VLL  GA   +  
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560

Query: 314 YNSQTAFQVAIIAGNFELAEVI 335
               T   VA   G+ ++A+++
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLL 582



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 12/241 (4%)

Query: 98  AQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAA 157
           A +L   K F  LH  A           + +  VA+LL +          +G  PL +AA
Sbjct: 555 AHSLATKKGFTPLHVAAK----------YGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604

Query: 158 QLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGL 217
             DN    L +L+ G A      ++G T +H A ++      +TLL+ GA  +    +G+
Sbjct: 605 HYDNQKVALLLLEKG-ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663

Query: 218 TPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMG 277
           TPL H A   G      LLL   A + ++ ++G   +H A +   V   + L  +GAD  
Sbjct: 664 TPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722

Query: 278 AQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKT 337
           A    G T L +   Y        LL +GAN + +  N  T    A   G+  +  V+  
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782

Query: 338 H 338
           H
Sbjct: 783 H 783



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 53/191 (27%), Positives = 83/191 (43%), Gaps = 2/191 (1%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           +G  PL ++A+ +   D+  VL   GA     T+ G T +H A +  +      LL   A
Sbjct: 529 NGYTPLHISAR-EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587

Query: 208 SPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLE 267
           + D     GLTPL H A    +     LLL   A    T +NG+  +H A +   +Q   
Sbjct: 588 AADSAGKNGLTPL-HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646

Query: 268 HLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAG 327
            LL YGA+       G T LH+ +         +LL +GAN  +   +  T+  +A    
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706

Query: 328 NFELAEVIKTH 338
              +A+++  H
Sbjct: 707 KVNVADILTKH 717



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 60/186 (32%), Positives = 80/186 (43%), Gaps = 2/186 (1%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLG 206
           +SG  P+ +AA + +   +L +L+NG A  D     G TA+H A R      +  LL  G
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 207 ASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHL 266
           A  D +     TPL H A   G     +LLL   A       NG+  +H + R G V   
Sbjct: 488 ALVDARAREEQTPL-HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546

Query: 267 EHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIA 326
             LL  GA        G T LH+ A Y     A++LL R A  D    N  T   VA   
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606

Query: 327 GNFELA 332
            N ++A
Sbjct: 607 DNQKVA 612



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/169 (27%), Positives = 79/169 (46%), Gaps = 1/169 (0%)

Query: 167 KVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALG 226
           K+L +  A+ + R  +G T +H A ++     +  L+  GAS       GLTP++ +A  
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 227 GGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTA 286
           G   +   LLL + A   +T+  G   +H A R G V+ +  LL  GA + A+     T 
Sbjct: 442 GHLNIVL-LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500

Query: 287 LHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           LHI +   +    ++LL   A+ D    N  T   ++   G  ++A V+
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 60/224 (26%), Positives = 95/224 (42%), Gaps = 15/224 (6%)

Query: 124 QLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           Q +  D V  LL+ G + +    D G  PL++A Q  +   +  +L+N     D + +  
Sbjct: 139 QENHIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLEN-----DTKGKVR 192

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSR--------GLTPLYHSALGGGDALCCEL 235
           L A+H A R+ +  +   LL    + D +           G TPL H A   G+     L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL-HIAAHYGNVNVATL 251

Query: 236 LLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQ 295
           LL+  A +  T  NG   +H A + G+   ++ LL  G  + A+   G T LH  A    
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 296 ESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHK 339
           +    +LL RGA    R  N  +   +A    + E  + +  HK
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 40/254 (15%)

Query: 119 FMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDF 178
           F+   +  + DKV   L  G+D N  +  +G   L LAA+ +    L++ L   G+ +D 
Sbjct: 35  FLRAARAGNLDKVVEYLKGGIDINTCN-QNGLNALHLAAK-EGHVGLVQELLGRGSSVDS 92

Query: 179 RTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLH 238
            T+ G TA+H A+    A  +  L+  GA+ + +   G TPLY +A      +  + LL 
Sbjct: 93  ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV-VKYLLE 151

Query: 239 DHAQLGITDENGWQEIHQACRFGHVQHLEHLL---------------------------- 270
           + A      E+G+  +  A + GH Q +  LL                            
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 271 ---FYGADMGAQ------NASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
               + AD+ ++        SG T LHI A Y   + A +LL RGA  D    N  T   
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 271

Query: 322 VAIIAGNFELAEVI 335
           VA   GN  + +++
Sbjct: 272 VASKRGNTNMVKLL 285



 Score = 35.8 bits (81), Expect = 0.38
 Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 38/282 (13%)

Query: 1189 ARREAEKVPREERKSPED--------KKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRL 1240
            + +E + +P +E +S +         KK +   + +   Q+  GL      S  +   + 
Sbjct: 1675 SEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGL----QASAEKAELKK 1730

Query: 1241 GGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVN 1300
            G +EE     P LAP P+ +     PL      P G         Q   E+E +     +
Sbjct: 1731 GSSEESLGEDPGLAPEPLPTVKATSPL--IEETPIGSIKDKVKALQKRVEDEQK---GRS 1785

Query: 1301 LPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTT---VPSPASGKP 1357
              P ++   ++  ++   R      P   A+  L +   A   PSP T       +S K 
Sbjct: 1786 KLPIRVKGKEDVPKKTTHR------PHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKT 1839

Query: 1358 SSEPPPAPESAAD-------SGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTD 1410
               PP +P S  +       S   E  + +SS    E  S +S  +     S  S   T+
Sbjct: 1840 ERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTE 1899

Query: 1411 THTSFA-DGHTFLLEKPPVPPKPKLKS--PLGKGPVTFRDPL 1449
             H   +  G T   ++PPV P  + +   P+  G    R P+
Sbjct: 1900 RHPPVSPSGKTD--KRPPVSPSGRTEKHPPVSPGRTEKRLPV 1939



 Score = 31.2 bits (69), Expect = 9.2
 Identities = 68/334 (20%), Positives = 108/334 (32%), Gaps = 64/334 (19%)

Query: 1117 PLDPSSPLALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPA 1176
            PL P +P            +S+  S   TP  + D   P P  +   A + +  +     
Sbjct: 2535 PLSPDTP------------SSEEVSYEVTP-KTTDVSTPKPAVIHECAEEDDSENGEKKR 2581

Query: 1177 FSPRSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQE 1236
            F+P    +  V   +  +++ +E ++  + KK        +S    A   V     +  E
Sbjct: 2582 FTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSV-----DVDE 2636

Query: 1237 PSRLGGAEEERPGTPELAPAP---MQSAAVAEP-------------LPSP--RAQPPGGT 1278
            P   G  E+E  G P L  +    + S++ +EP             LP P  R QPP   
Sbjct: 2637 PKHTGSGEDES-GVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPL 2695

Query: 1279 PA---------------------------DAGPGQGSSEEEPELVFAVNLPPAQLSSSDE 1311
            P+                           D     G SEEE +    +      +S+  E
Sbjct: 2696 PSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAE 2755

Query: 1312 ETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADS 1371
            +   +        P     +G    +P +   P  + + SP       +P    ES A  
Sbjct: 2756 DRSYDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQ 2815

Query: 1372 GVEEADTRSSSDPHLETTSTISTVSSMSTLSSES 1405
            G  E DT           S  +   S S  SS S
Sbjct: 2816 GTHEKDTEGEELDVSRAESPQADCPSESFSSSSS 2849


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 67/224 (29%), Positives = 110/224 (49%), Gaps = 8/224 (3%)

Query: 112 TKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKN 171
           T  ++  FM +V +     V++L+  G  PN  +   GE  L +AA+   A ++++ L  
Sbjct: 435 TPIHVAAFMGHVNI-----VSQLMHHGASPNTTNV-RGETALHMAARSGQA-EVVRYLVQ 487

Query: 172 GGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDAL 231
            GA ++ + +D  T +H + R   A  +  LL  GASP+   + G TPL+ SA  G + +
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDV 547

Query: 232 CCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICA 291
              LL H  A L IT + G+  +H A ++G ++    LL   A   A   SG T LH+ A
Sbjct: 548 AAFLLDHG-ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606

Query: 292 LYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
            Y+ +  A +LL +GA+      N  T   +A      ++A  +
Sbjct: 607 HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 650



 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 66/207 (31%), Positives = 97/207 (46%), Gaps = 4/207 (1%)

Query: 130 KVAR-LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           KVA+ LLDK  +PN    + G  PL +A +  N   ++++L   GA +   T  GLT +H
Sbjct: 381 KVAKVLLDKKANPNAKALN-GFTPLHIACK-KNRIKVMELLLKHGASIQAVTESGLTPIH 438

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A    +   ++ L+  GASP+  + RG T L H A   G A     L+ D AQ+    +
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETAL-HMAARSGQAEVVRYLVQDGAQVEAKAK 497

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +    +H + R G    ++ LL  GA   A   SG T LH+ A    E  A  LL  GA+
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVI 335
             +      T   VA   G  E+A ++
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLL 584



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 59/191 (30%), Positives = 94/191 (49%), Gaps = 2/191 (1%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           SG  PL +AA   N  ++  +L N  A +DF  R+ +T +H A+++ NA  +  LLD GA
Sbjct: 234 SGFTPLHIAAHYGNI-NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA 292

Query: 208 SPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLE 267
             D K   GLTPL+  A  G + +  E+LL   A +    +NG   +H A +  H+  ++
Sbjct: 293 KIDAKTRDGLTPLHCGARSGHEQV-VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQ 351

Query: 268 HLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAG 327
            LL +   +        TALH+ A       A+VLL + AN + +  N  T   +A    
Sbjct: 352 LLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKN 411

Query: 328 NFELAEVIKTH 338
             ++ E++  H
Sbjct: 412 RIKVMELLLKH 422



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 58/187 (31%), Positives = 89/187 (47%), Gaps = 2/187 (1%)

Query: 152 PLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDY 211
           PL +A++  NA +++K+L + GA +D +TRDGLT +HC  R  +   +  LLD  A    
Sbjct: 271 PLHVASKRGNA-NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329

Query: 212 KDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLF 271
           K   GL+PL H A  G    C +LLL  +  +     +    +H A   GH +  + LL 
Sbjct: 330 KTKNGLSPL-HMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388

Query: 272 YGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFEL 331
             A+  A+  +G T LHI    N+     +LL  GA+      +  T   VA   G+  +
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448

Query: 332 AEVIKTH 338
              +  H
Sbjct: 449 VSQLMHH 455



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 63/203 (31%), Positives = 91/203 (44%), Gaps = 3/203 (1%)

Query: 131 VARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCA 190
           V  LLD+   P      +G  PL +A Q D+  + +++L      +D  T D LTA+H A
Sbjct: 317 VEMLLDRAA-PILSKTKNGLSPLHMATQGDHL-NCVQLLLQHNVPVDDVTNDYLTALHVA 374

Query: 191 TRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENG 250
               +      LLD  A+P+ K   G TPL H A         ELLL   A +    E+G
Sbjct: 375 AHCGHYKVAKVLLDKKANPNAKALNGFTPL-HIACKKNRIKVMELLLKHGASIQAVTESG 433

Query: 251 WQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRD 310
              IH A   GHV  +  L+ +GA     N  G TALH+ A   Q    R L+  GA  +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493

Query: 311 VRNYNSQTAFQVAIIAGNFELAE 333
            +  + QT   ++   G  ++ +
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQ 516



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 60/212 (28%), Positives = 100/212 (47%), Gaps = 4/212 (1%)

Query: 126 HSTDKVARLL-DKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGL 184
           +   KVA LL D+G  P+     +G  PL +AA+  N  D+   L   GA  +  TR G+
Sbjct: 608 YDNQKVALLLLDQGASPHAA-AKNGYTPLHIAAK-KNQMDIATTLLEYGADANAVTRQGI 665

Query: 185 TAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG 244
            +VH A ++ +   ++ LL   A+ +  +  GLTPL H A         E+L++  A + 
Sbjct: 666 ASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPL-HLAAQEDRVNVAEVLVNQGAHVD 724

Query: 245 ITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLF 304
              + G+  +H  C +G+++ +  LL + A + A+  +G T LH  A         VLL 
Sbjct: 725 AQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 784

Query: 305 RGANRDVRNYNSQTAFQVAIIAGNFELAEVIK 336
             A+ +    N  TA  +A   G   + + +K
Sbjct: 785 NNASPNELTVNGNTALGIARRLGYISVVDTLK 816



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 71/247 (28%), Positives = 102/247 (41%), Gaps = 34/247 (13%)

Query: 124 QLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG 183
           +L   D V +LL +G  PN     SG  PL L+A+ +   D+   L + GA L   T+ G
Sbjct: 508 RLGKADIVQQLLQQGASPNAATT-SGYTPLHLSAR-EGHEDVAAFLLDHGASLSITTKKG 565

Query: 184 LTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELL-----LH 238
            T +H A +         LL   ASPD     GLTPL+ +A      +   LL      H
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625

Query: 239 DHAQLGIT----------------------DEN-----GWQEIHQACRFGHVQHLEHLLF 271
             A+ G T                      D N     G   +H A + GHV  +  LL 
Sbjct: 626 AAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLG 685

Query: 272 YGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFEL 331
             A++   N SG T LH+ A  ++ + A VL+ +GA+ D +     T   V    GN ++
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745

Query: 332 AEVIKTH 338
              +  H
Sbjct: 746 VNFLLQH 752



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 53/187 (28%), Positives = 90/187 (48%), Gaps = 2/187 (1%)

Query: 153 LSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYK 212
           L +AA+ D+      +L+N   + D  ++ G T +H A    N    T LL+  A+ D+ 
Sbjct: 206 LHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 213 DSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFY 272
               +TPL H A   G+A   +LLL   A++     +G   +H   R GH Q +E LL  
Sbjct: 265 ARNDITPL-HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323

Query: 273 GADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELA 332
            A + ++  +G + LH+    +  +C ++LL      D    +  TA  VA   G++++A
Sbjct: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVA 383

Query: 333 EVIKTHK 339
           +V+   K
Sbjct: 384 KVLLDKK 390



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 45/172 (26%), Positives = 80/172 (46%), Gaps = 1/172 (0%)

Query: 167 KVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALG 226
           KVL +  A+ + +  +G T +H A ++     +  LL  GAS       GLTP++ +A  
Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443

Query: 227 GGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTA 286
           G   +  +L+ H  A    T+  G   +H A R G  + + +L+  GA + A+     T 
Sbjct: 444 GHVNIVSQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 287 LHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
           LHI A   +    + LL +GA+ +    +  T   ++   G+ ++A  +  H
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 47/190 (24%), Positives = 86/190 (45%), Gaps = 10/190 (5%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           +G  PL +AAQ +N  +++K L + GA     T DG T +  A +Q +   ++ LL+   
Sbjct: 139 NGFTPLYMAAQ-ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE--- 194

Query: 208 SPDYKDSRGLT--PLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQH 265
                D++G    P  H A    D     LLL +     +  ++G+  +H A  +G++  
Sbjct: 195 ----NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250

Query: 266 LEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAII 325
              LL   A +     +  T LH+ +     +  ++LL RGA  D +  +  T       
Sbjct: 251 ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR 310

Query: 326 AGNFELAEVI 335
           +G+ ++ E++
Sbjct: 311 SGHEQVVEML 320



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 50/179 (27%), Positives = 81/179 (45%), Gaps = 5/179 (2%)

Query: 157 AQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRG 216
           A L    +++KVL   GA+++ ++++G T ++ A ++ +   +  LLD GAS       G
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173

Query: 217 LTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADM 276
            TPL  +   G D +   LL +D        +     +H A R    +    LL    + 
Sbjct: 174 FTPLAVALQQGHDQVVSLLLEND-----TKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228

Query: 277 GAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
             ++ SG T LHI A Y   + A +LL R A  D    N  T   VA   GN  + +++
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 57/221 (25%), Positives = 100/221 (45%), Gaps = 19/221 (8%)

Query: 115 NLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGA 174
           +L+K +DY++             G+D N  +  +G   L LA++ +   +++  L    A
Sbjct: 53  HLEKALDYIK------------NGVDINICN-QNGLNALHLASK-EGHVEVVSELLQREA 98

Query: 175 HLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCE 234
           ++D  T+ G TA+H A+    A  +  L+  GA+ + +   G TPLY +A         +
Sbjct: 99  NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA-QENHLEVVK 157

Query: 235 LLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYN 294
            LL + A   +  E+G+  +  A + GH Q +  LL    +   +      ALHI A  +
Sbjct: 158 FLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKD 213

Query: 295 QESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
               A +LL    N DV + +  T   +A   GN  +A ++
Sbjct: 214 DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLL 254



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 38/180 (21%), Positives = 77/180 (42%), Gaps = 38/180 (21%)

Query: 156 AAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSR 215
           A  L+ A D +K     G  ++   ++GL A+H A+++ +   ++ LL   A+ D    +
Sbjct: 51  AGHLEKALDYIK----NGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKK 106

Query: 216 GLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGAD 275
           G T L+ ++L                                   G  + ++ L+  GA+
Sbjct: 107 GNTALHIASLA----------------------------------GQAEVVKVLVTNGAN 132

Query: 276 MGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           + AQ+ +G T L++ A  N     + LL  GA++ +   +  T   VA+  G+ ++  ++
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 25/83 (30%), Positives = 39/83 (46%)

Query: 256 QACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYN 315
           +A R GH++     +  G D+   N +G  ALH+ +          LL R AN D     
Sbjct: 47  RAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKK 106

Query: 316 SQTAFQVAIIAGNFELAEVIKTH 338
             TA  +A +AG  E+ +V+ T+
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTN 129


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 72/240 (30%), Positives = 107/240 (44%), Gaps = 36/240 (15%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D V  LL+ G D + H  ++G  PL  AA + +A+ ++  L   GA +D    +G T + 
Sbjct: 762 DVVDLLLEGGADVD-HTDNNGRTPLLAAASMGHAS-VVNTLLFWGAAVDSIDSEGRTVLS 819

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A+ Q N   + TLLD G   +++D  G TPL H A   G  L CE L+   A+    D 
Sbjct: 820 IASAQGNVEVVRTLLDRGLDENHRDDAGWTPL-HMAAFEGHRLICEALIEQGARTNEIDN 878

Query: 249 NGW-------QEIHQAC--------------------------RFGHVQHLEHLLFYGAD 275
           +G        QE H  C                            GH   +E L  +GAD
Sbjct: 879 DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938

Query: 276 MGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           +  ++A G   L+I AL NQ + A   L  GAN +  +   +TA  V+   G+ E+ +V+
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 65/221 (29%), Positives = 103/221 (46%), Gaps = 9/221 (4%)

Query: 131 VARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCA 190
           V+ L+D+G + +  D D G  PL +AA  +   D++ +L  GGA +D    +G T +  A
Sbjct: 731 VSLLIDRGAEVDHCDKD-GMTPLLVAAY-EGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788

Query: 191 TRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENG 250
               +A+ + TLL  GA+ D  DS G T L   A   G+      LL         D+ G
Sbjct: 789 ASMGHASVVNTLLFWGAAVDSIDSEGRTVL-SIASAQGNVEVVRTLLDRGLDENHRDDAG 847

Query: 251 WQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRD 310
           W  +H A   GH    E L+  GA     +  G     + +      C ++LL   +N D
Sbjct: 848 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID 907

Query: 311 VRNYNSQTAFQVAIIAGNFELAEVIKTH------KDSDVVP 345
            R Y+ + A +VA + G+ ++ E++ +H      KD+D  P
Sbjct: 908 QRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 62/212 (29%), Positives = 101/212 (47%), Gaps = 8/212 (3%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D V  LL  G + N  D + G   L  AA + +  ++++ L + GA ++    DG TA+ 
Sbjct: 658 DIVLNLLQHGAEVNKAD-NEGRTALIAAAYMGHR-EIVEHLLDHGAEVNHEDVDGRTALS 715

Query: 189 CAT-----RQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
            A       + +A+ ++ L+D GA  D+ D  G+TPL  +A  G   +  +LLL   A +
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVV-DLLLEGGADV 774

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
             TD NG   +  A   GH   +  LLF+GA + + ++ G T L I +        R LL
Sbjct: 775 DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL 834

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
            RG + + R+    T   +A   G+  + E +
Sbjct: 835 DRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 85/358 (23%), Positives = 137/358 (38%), Gaps = 47/358 (13%)

Query: 127  STDKVARLLDKGLDPNFHDPDSGECPLSLAA-------------------QLDNAT---- 163
            + + V  LLD+GLD N  D D+G  PL +AA                   ++DN      
Sbjct: 826  NVEVVRTLLDRGLDENHRD-DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPF 884

Query: 164  ---------DLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDS 214
                     D +++L    +++D R  DG  A+  A  + +   +  L   GA  + KD+
Sbjct: 885  ILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944

Query: 215  RGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGA 274
             G   LY  AL        E  L + A +  +D  G   +H +C  GH++ ++ L+ Y A
Sbjct: 945  DGRPTLYILALEN-QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003

Query: 275  DMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEV 334
            D+ A +    +AL   A        ++L+  GA  D       TA  +A   G+ ++ +V
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQV 1063

Query: 335  IKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGEAQPAASPGPSLR 394
            +  H      P           R+A  +G +    L       +L G      SP P   
Sbjct: 1064 LLEH---GADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNG-----CSPSP--- 1112

Query: 395  SLPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISDPGPGPGGVGGAPLPPP 452
               H +  + LQ    + +    +SN SG   G   Q  +     GP     +P   P
Sbjct: 1113 --VHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESP 1168



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/201 (27%), Positives = 85/201 (42%), Gaps = 3/201 (1%)

Query: 125 LHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGL 184
           L   D +  LLD G   N    DS    L   A    + D++ +L + GA L+     G 
Sbjct: 522 LEREDSIRTLLDNGASVN--QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH 579

Query: 185 TAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG 244
           T +  A RQ +   +  L+  GA+ ++ D  G T L  SA  GG       LL+   ++ 
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTAL-RSAAWGGHTEVVSALLYAGVKVD 638

Query: 245 ITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLF 304
             D +    +  A   GH   + +LL +GA++   +  G TAL   A          LL 
Sbjct: 639 CADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD 698

Query: 305 RGANRDVRNYNSQTAFQVAII 325
            GA  +  + + +TA  VA +
Sbjct: 699 HGAEVNHEDVDGRTALSVAAL 719



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 53/205 (25%), Positives = 88/205 (42%), Gaps = 5/205 (2%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           L+  G   N  D D   C +  A + +   D ++ L + GA ++    +G T +  A   
Sbjct: 500 LVKAGAHVNSED-DRTSCIVRQALERE---DSIRTLLDNGASVNQCDSNGRTLLANAAYS 555

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQE 253
            +   +  L+  GA  + +D+ G TPL  +A  G   +    L+   A +  TD++GW  
Sbjct: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV-NCLIGCGANINHTDQDGWTA 614

Query: 254 IHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRN 313
           +  A   GH + +  LL+ G  +   +A   TAL   A    E     LL  GA  +  +
Sbjct: 615 LRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKAD 674

Query: 314 YNSQTAFQVAIIAGNFELAEVIKTH 338
              +TA   A   G+ E+ E +  H
Sbjct: 675 NEGRTALIAAAYMGHREIVEHLLDH 699


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 70/241 (29%), Positives = 109/241 (45%), Gaps = 17/241 (7%)

Query: 128 TDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAV 187
           +D   +LL  G D +  D D G   L  AA   N  + L +L N GA  + + + G + +
Sbjct: 385 SDCCRKLLSSGFDIDTPD-DFGRTCLHAAAAGGNL-ECLNLLLNTGADFNKKDKFGRSPL 442

Query: 188 HCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITD 247
           H A    N   L  L+  GAS +  D RG TPL+++A    D  C E LL + A  GI D
Sbjct: 443 HYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRD 502

Query: 248 ENGWQEIHQACRFGHVQHLEHLL----------FYGADM--GAQNASGNTALHICALYNQ 295
           + G+  +H +  +GH   L+ +             G DM   + N +  + LH+ A +  
Sbjct: 503 KQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGH 562

Query: 296 ESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVP---FRETPSY 352
                VL+    + DVRN + +T   +A   G+ E  +V+     S +V     + TP +
Sbjct: 563 HQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIH 622

Query: 353 A 353
           A
Sbjct: 623 A 623



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 59/228 (25%), Positives = 100/228 (43%), Gaps = 11/228 (4%)

Query: 100 NLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQL 159
           N  D K    +H  A    +M ++++     V  L+  G +    D  S   PL  AA  
Sbjct: 167 NAFDKKDRRAIHWAA----YMGHIEV-----VKLLVSHGAEVTCKDKKS-YTPLHAAAS- 215

Query: 160 DNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTP 219
                ++K L + G  ++     G T +H A        +  L+D GA  + K+ +G TP
Sbjct: 216 SGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTP 275

Query: 220 LYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQ 279
           L+ +A     ALC ELL+ + A + +  ++G   +H     G     + ++  GA +  +
Sbjct: 276 LHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335

Query: 280 NASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAG 327
           + +GNT LHI A Y  E     L+  GA+   R  +      +A ++G
Sbjct: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 68/236 (28%), Positives = 104/236 (44%), Gaps = 17/236 (7%)

Query: 103 DDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDS-GECPLSLAAQLDN 161
           D K +  LH  A+               V  LLD G+D N  +P++ G  PL +A    N
Sbjct: 203 DKKSYTPLHAAASSGMI---------SVVKYLLDLGVDMN--EPNAYGNTPLHVACY--N 249

Query: 162 ATDLL-KVLKNGGAHLDFRTRDGLTAVHCATRQRNAA-ALTTLLDLGASPDYKDSRGLTP 219
             D++   L + GA ++ +   G T +H A    + A  L  L+  GA  + K   G TP
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309

Query: 220 LYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQ 279
           L+ +AL G  +   + ++   A +   D+NG   +H A R+GH   +  L+  GAD   +
Sbjct: 310 LHMTALHGRFSRS-QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR 368

Query: 280 NASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
              G   LH+ AL     C R LL  G + D  +   +T    A   GN E   ++
Sbjct: 369 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 58/209 (27%), Positives = 88/209 (42%), Gaps = 11/209 (5%)

Query: 100 NLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQL 159
           N  ++K F  LH  A           H    +  L+  G D N    D G+ PL + A L
Sbjct: 266 NQKNEKGFTPLHFAA--------ASTHGALCLELLVGNGADVNMKSKD-GKTPLHMTA-L 315

Query: 160 DNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTP 219
                  + +   GA +D   ++G T +H A R  +   + TL+  GA    +   G+ P
Sbjct: 316 HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFP 375

Query: 220 LYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQ 279
           L+ +AL G    CC  LL     +   D+ G   +H A   G+++ L  LL  GAD   +
Sbjct: 376 LHLAALSGFSD-CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434

Query: 280 NASGNTALHICALYNQESCARVLLFRGAN 308
           +  G + LH  A      C   L+  GA+
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGAS 463



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 56/210 (26%), Positives = 99/210 (47%), Gaps = 4/210 (1%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           + V  LL +G + N  D       +  AA + +  +++K+L + GA +  + +   T +H
Sbjct: 154 EMVKLLLSRGANINAFDKKDRRA-IHWAAYMGHI-EVVKLLVSHGAEVTCKDKKSYTPLH 211

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A      + +  LLDLG   +  ++ G TPL+ +   G D +  EL+    A +   +E
Sbjct: 212 AAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI-DCGAIVNQKNE 270

Query: 249 NGWQEIHQACRFGH-VQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGA 307
            G+  +H A    H    LE L+  GAD+  ++  G T LH+ AL+ + S ++ ++  GA
Sbjct: 271 KGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGA 330

Query: 308 NRDVRNYNSQTAFQVAIIAGNFELAEVIKT 337
             D  + N  T   +A   G+  L   + T
Sbjct: 331 VIDCEDKNGNTPLHIAARYGHELLINTLIT 360



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 55/202 (27%), Positives = 89/202 (44%), Gaps = 6/202 (2%)

Query: 131 VARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCA 190
           V  L+D G   N  + + G  PL  AA   +    L++L   GA ++ +++DG T +H  
Sbjct: 255 VNELIDCGAIVNQKN-EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 313

Query: 191 TRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLH--DHAQLGITDE 248
                 +   T++  GA  D +D  G TPL+ +A  G + L   L+    D A+ GI   
Sbjct: 314 ALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI--- 370

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +G   +H A   G       LL  G D+   +  G T LH  A      C  +LL  GA+
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430

Query: 309 RDVRNYNSQTAFQVAIIAGNFE 330
            + ++   ++    A    N++
Sbjct: 431 FNKKDKFGRSPLHYAAANCNYQ 452



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 44/163 (26%), Positives = 78/163 (47%), Gaps = 1/163 (0%)

Query: 176 LDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCEL 235
           ++F+  +  T +H A    +A  +  L+  GA  + KDS+ LTPL H A+        ++
Sbjct: 34  VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL-HRAVASCSEEAVQV 92

Query: 236 LLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQ 295
           LL   A +   D+N    +H A     V+  E L+   +++   + +G TALH  A    
Sbjct: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152

Query: 296 ESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
               ++LL RGAN +  +   + A   A   G+ E+ +++ +H
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 14/247 (5%)

Query: 96  VYAQNLID-DKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLS 154
           V  Q+L+D D + +   T  +L  F  +V+      V  L+++G      D      P+ 
Sbjct: 568 VLVQSLLDLDVRNSSGRTPLDLAAFKGHVEC-----VDVLINQGASILVKDYILKRTPIH 622

Query: 155 LAAQLDNATDLLKVLKNGGAH--LDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYK 212
            AA   ++  L  ++ N      +D +  +G T +  +    +   + +LL+ GA+ D K
Sbjct: 623 AAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK 682

Query: 213 DSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFY 272
           D  G T L+  A+ G +  C + LL   A+  + D  G   IH +   GH+  L  LL  
Sbjct: 683 DKWGRTALHRGAVTGHEE-CVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQS 741

Query: 273 GADMGAQNAS----GNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
            A M A  A+    G TALH       E+C  +LL +   +     N+ +    A+I  N
Sbjct: 742 AASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDN 800

Query: 329 FELAEVI 335
              AE++
Sbjct: 801 EGAAEML 807



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 59/220 (26%), Positives = 94/220 (42%), Gaps = 9/220 (4%)

Query: 127 STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA 186
           S + V  LL    D N  D +  + PL +AA  + A    + L    ++++   R G TA
Sbjct: 86  SEEAVQVLLKHSADVNARDKN-WQTPLHIAAA-NKAVKCAEALVPLLSNVNVSDRAGRTA 143

Query: 187 VHCATRQRNAAALTTLLDLGASP---DYKDSRGLTPLYHSALGGGDALCCELLLHDHAQL 243
           +H A    +   +  LL  GA+    D KD R +    H A   G     +LL+   A++
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAI----HWAAYMGHIEVVKLLVSHGAEV 199

Query: 244 GITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
              D+  +  +H A   G +  +++LL  G DM   NA GNT LH+     Q+     L+
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259

Query: 304 FRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDV 343
             GA  + +N    T    A  + +  L   +     +DV
Sbjct: 260 DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 52/180 (28%), Positives = 79/180 (43%), Gaps = 4/180 (2%)

Query: 152 PLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDY 211
           PL LAA   +    L+VL      LD R   G T +  A  + +   +  L++ GAS   
Sbjct: 553 PLHLAAYHGHH-QALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611

Query: 212 KDSRGLTPLYHSALGGGDALCCELLLHD---HAQLGITDENGWQEIHQACRFGHVQHLEH 268
           KD        H+A   G + C  LL+ +      + I D NG   +  +   GH   +  
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671

Query: 269 LLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
           LL  GA++ A++  G TALH  A+   E C   LL  GA   +R+   +T   ++   G+
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 48/148 (32%), Positives = 73/148 (49%), Gaps = 7/148 (4%)

Query: 182 DGLTAVHCATRQRNAAALTTLLD-LGAS-PDYKDSRGLTPLYHSALGGGDALCCELLLHD 239
           +  + +HCA    N  A   L+D LGAS  +  DS+G TPL H+A       C +LLL  
Sbjct: 787 NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPL-HAAAFTDHVECLQLLLSH 845

Query: 240 HAQLGITDENGWQEIHQACRFGHVQHLEHLLFYG-ADMGAQNASGNTALHICALYNQESC 298
           +AQ+   D  G   +  A   G    +E L+    A++  Q+ S NTALH+      E+ 
Sbjct: 846 NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETS 905

Query: 299 ARVLLFRGANRDVRNYNS---QTAFQVA 323
           A ++L +  +R++ N  +   QT   VA
Sbjct: 906 ALLILEKITDRNLINATNAALQTPLHVA 933



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 58/233 (24%), Positives = 94/233 (40%), Gaps = 38/233 (16%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           +G+ PL L+  L+  TD +  L N GA++D + + G TA+H      +   +  LL  GA
Sbjct: 652 NGQTPLMLSV-LNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710

Query: 208 SPDYKDSRGLTPLYHSALGGGDALCCELLLHD---HAQLGITDENGWQEIHQACRFGHVQ 264
               +DSRG TP++ SA  G   +   LL       A     D +G+  +H AC  GH  
Sbjct: 711 KCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHET 770

Query: 265 HLEHLL---------------------------------FYGADM-GAQNASGNTALHIC 290
            +E LL                                   GA +  A ++ G T LH  
Sbjct: 771 CVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAA 830

Query: 291 ALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDV 343
           A  +   C ++LL   A  +  +   +T   +A   G     E++ +   +++
Sbjct: 831 AFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 50/195 (25%), Positives = 83/195 (42%), Gaps = 15/195 (7%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           + E PL +  +  + TD+L          D   R  ++ +H A    +  AL  L+    
Sbjct: 525 ASETPLDVLMET-SGTDMLS---------DSDNRATISPLHLAAYHGHHQALEVLVQSLL 574

Query: 208 SPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQE-IHQACRFGHVQHL 266
             D ++S G TPL  +A  G    C ++L++  A + + D    +  IH A   GH + L
Sbjct: 575 DLDVRNSSGRTPLDLAAFKG-HVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 633

Query: 267 EHLLFYGADMGA---QNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVA 323
             L+       A   Q+ +G T L +  L     C   LL +GAN D ++   +TA    
Sbjct: 634 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 693

Query: 324 IIAGNFELAEVIKTH 338
            + G+ E  + +  H
Sbjct: 694 AVTGHEECVDALLQH 708



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 46/161 (28%), Positives = 65/161 (40%), Gaps = 4/161 (2%)

Query: 152 PLSLAAQLDNATDLLKVLKNGGAHLDFRTRD-GLTAVHCATRQRNAAALTTLLDLGASPD 210
           PL  A   DN      ++   GA +   T   G T +H A    +   L  LL   A  +
Sbjct: 791 PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850

Query: 211 YKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLL 270
             DS G TPL  +A  G       L+    A+L + D +    +H AC  GH      +L
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910

Query: 271 FYGAD---MGAQNASGNTALHICALYNQESCARVLLFRGAN 308
               D   + A NA+  T LH+ A        + LL +GA+
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGAS 951



 Score = 39.3 bits (90), Expect = 0.034
 Identities = 29/117 (24%), Positives = 47/117 (40%)

Query: 219 PLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGA 278
           P    A+  GD      L+     +   D      +H A   G  + +E L+  GA + A
Sbjct: 10  PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69

Query: 279 QNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           +++   T LH       E   +VLL   A+ + R+ N QT   +A      + AE +
Sbjct: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126


>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 158/626 (25%), Positives = 207/626 (33%), Gaps = 128/626 (20%)

Query: 832  PPQTAPPP-------PPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAA 884
            PP +APP          AP Y   GPPPA  PPPPP RA     +S  P   + + +  +
Sbjct: 753  PPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAAS--PDPPSAVASPGS 810

Query: 885  GLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRP-PGP 943
            GL  PG   G   Y      +         A E    PRP     PP+    RP P PGP
Sbjct: 811  GLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGP 870

Query: 944  DSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPG-GGSFAREPS 1002
                            P    R K   V Q+  E         V     G  G+ ARE  
Sbjct: 871  ---------------LPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETG 915

Query: 1003 PTHRGPRPGGLDYGAG---DGPGLAFGGPGPAKD------RRLEERRRSTVFLSVGAIEG 1053
            P   G  PG  +   G   D   L  G   P+          LE   +    +   A E 
Sbjct: 916  PRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLENGDQRAPGIEEKAAEN 975

Query: 1054 SAPGA--------DLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPLVSGPSLGPS 1105
             A G+        +   L P R  +E+ L  G        L SP +  K LV+G    P 
Sbjct: 976  GALGSPEREEKVLENGELTPPRR-EEKALENGE-------LRSPEAGEKVLVNGGLTPPK 1027

Query: 1106 GSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTP-VHSPDADRPGPLFVD-VQ 1163
                +    G          L             P R+P P   +P++  P P   +   
Sbjct: 1028 SEDKVSENGG----------LRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAP 1077

Query: 1164 ARDPERGSLASPAFSPRS---PAWIPV-PARREAEKVPREERKSPEDKKSMILSVLDTSL 1219
                ER    S   S R+    A  P+ PA +     P  ER++PE              
Sbjct: 1078 ETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPE----------TGGA 1127

Query: 1220 QRPAGLIVVHATSNGQEPSRLGGAEEERPGT------------------PELAPAPMQSA 1261
             R  G   +   S G+ P   G A    PG+                  P L P P    
Sbjct: 1128 PRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQP 1187

Query: 1262 AVAEPLPSPRAQP--------------PGGTPADAGPGQGSSEEE--PELV-FAVNLPPA 1304
               EP P PRA+P               GG  A +G G     E   PE+    ++L P 
Sbjct: 1188 RRLEPAP-PRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPP 1246

Query: 1305 QLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSE---- 1360
            Q   + E+ +  L+R+ L  PP       L  TP  GPGP         +G    E    
Sbjct: 1247 Q--GNSEQIKARLSRLSLALPP-------LTLTPFPGPGPRRPPWEGADAGAAGGEAGGA 1297

Query: 1361 --PPPAPESAADSGVEEADTRSSSDP 1384
              P PA E   D   +E +   ++ P
Sbjct: 1298 GAPGPAEEDGEDEDEDEEEDEEAAAP 1323



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 231/920 (25%), Positives = 314/920 (34%), Gaps = 202/920 (21%)

Query: 831  PPPQTAPPPPPAPYYFDSGPPPAFSPPPP-------------PGRAYDTV----RSSFKP 873
            PP    PPPPP    F    PPA S P P             PG   D V     SS   
Sbjct: 445  PPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGL 504

Query: 874  GLE-----ARLGAGAAG---LYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPP 925
             LE     AR GAG  G    ++P +A  P P+          +      P    A  P 
Sbjct: 505  NLECLWEKARRGAGRGGGAPAWQPASA-PPAPHANPSNPFYEALSTPSVLPVI-SARSPS 562

Query: 926  PAATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAAL 985
             ++    R +    PP P  P  +       + AP  PQ      V QL    ++  A+ 
Sbjct: 563  VSSEYYIRLEEHGSPPEPLFP-NDWDPLDPGVPAPQAPQAPSE--VPQLV---SETWASP 616

Query: 986  AVGSPGPGGGSFAREPSPTHRGPRPGGLDYG---AGDGPGLAFGGPGPAKDRRLEERRRS 1042
               +P P     +   S    G  P G   G   AGD P    G  G A     EE    
Sbjct: 617  LFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGD-PAEVLGERGTAPWVEEEEEEE- 674

Query: 1043 TVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALK------PL 1096
                     EGS+PG D  S           LG GP+  R   LP P+ + +      PL
Sbjct: 675  ---------EGSSPGEDSSS-----------LGGGPS--RRGPLPCPLCSREGACSCLPL 712

Query: 1097 VSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTPVHSPDADRPG 1156
              G ++   G    HP  G P  P           + +L ++  S +  P+ +P A  P 
Sbjct: 713  ERGDAVAGWGG---HPALGCPHPPED---------DSSLRAERGSLADLPM-APPASAP- 758

Query: 1157 PLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLD 1216
            P F+     DP  G+ A+P +  R P   P P      + P +   SP D  S + S   
Sbjct: 759  PEFL-----DPLMGA-AAPQYPGRGPPPAP-PPPPPPPRAPADPAASP-DPPSAVAS--- 807

Query: 1217 TSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQP-- 1274
                  +GL     +S G +P    G E E P +PE A  P   AA  E +P PRA P  
Sbjct: 808  ----PGSGL-----SSPGPKPGD-SGYETETPFSPEGA-FPGGGAAEEEGVPRPRAPPEP 856

Query: 1275 --PGG--TPADAGP-GQGSSEEEPELVFAVNLPPAQLSSSDEETREELA----------- 1318
              PG    P D GP       E+P  V  V+     +S  ++ TR  L            
Sbjct: 857  PDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETGP 916

Query: 1319 -RIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASG-----KPSSEPPPAPESAADSG 1372
             + G  P   E   G+     + G G    ++  P +G           P   E AA++G
Sbjct: 917  RKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLENGDQRAPGIEEKAAENG 976

Query: 1373 VEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKP 1432
               +  R   +  LE      T       + E+GEL         G   L+     PPK 
Sbjct: 977  ALGSPER--EEKVLENGEL--TPPRREEKALENGELRSPEA----GEKVLVNGGLTPPKS 1028

Query: 1433 KLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGD 1492
            + K              + ++               G   A GP      +++  + WG 
Sbjct: 1029 EDK--------------VSENGGLRFPRNTERPPETGPWRAPGP------WEKTPESWG- 1067

Query: 1493 PVESRGLPGPE---DDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAA 1549
            P  + G P PE   +  P   + +SS         R+ GE   G LG    PA K+    
Sbjct: 1068 PAPTIGEPAPETSLERAPAPSAVVSS---------RNGGETAPGPLG----PAPKN---- 1110

Query: 1550 ARLFSSLGELSSISAQRSP--GG----PGGGASYSVRPSGRYPVARRAPSPVKPASLERV 1603
                   G L   + +R+P  GG    PG G    +   GR PV         P S    
Sbjct: 1111 -------GTLEPGTERRAPETGGAPRAPGAG-RLDLGSGGRAPVGTGTAPGGGPGS---- 1158

Query: 1604 EGLGAGAGGAGR------PFGLTPPTILKSSSL--SIPHEPKEVRFVVRSVSARSRSPSP 1655
             G+ A AG          P  L PP   +   L  + P    EV       +  SR+   
Sbjct: 1159 -GVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGD 1217

Query: 1656 SPLPSPASGPGPGAPGPRRP 1675
            + L      P P   GP  P
Sbjct: 1218 TALSGDGDPPKPERKGPEMP 1237



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 109/479 (22%), Positives = 158/479 (32%), Gaps = 70/479 (14%)

Query: 746  IADADSRAATVKQRPTSRRI--TPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGE-- 801
            + + D RA  ++++        +P     + E   L  P +   +L  G  R+   GE  
Sbjct: 958  LENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKV 1017

Query: 802  -----------DEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGP 850
                       ++K++     RFPR+T         R   P  +T     PAP   +  P
Sbjct: 1018 LVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAP 1077

Query: 851  PPAFSPPPPPGRAYDT---------------VRSSFKPGLE---------------ARLG 880
              +    P P     +                  + +PG E                RL 
Sbjct: 1078 ETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLD 1137

Query: 881  AGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPER-----PK 935
             G+ G    G    P   P     A++  +  ++ P+    P PPP    P R     P+
Sbjct: 1138 LGSGGRAPVGTGTAPGGGPGSGVDAKAGWV-DNTRPQPPPPPLPPPPEAQPRRLEPAPPR 1196

Query: 936  RRPR------PPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQL-------QVEDAQER 982
             RP       P  PDS      A S     P KP+R K P + +L       Q    Q +
Sbjct: 1197 ARPEVAPEGEPGAPDSRAGGDTALSGD-GDPPKPER-KGPEMPRLFLDLGPPQGNSEQIK 1254

Query: 983  AALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGPGPAKDRRLEERRRS 1042
            A L+  S      +    P P  R P   G D GA  G     G PGPA++   E+    
Sbjct: 1255 ARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDG-EDEDED 1313

Query: 1043 TVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDL--LLPSPVSALKPLVSGP 1100
                   A  G+A G   P    +  +   +      A R L  LL SP  A +P  S  
Sbjct: 1314 EEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSEL 1373

Query: 1101 SLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTPVHSPDADRPGPLF 1159
                   +F   +T    D  +P    L+ +        PS  P P   P    PG  F
Sbjct: 1374 ERKRKMVSFHGDVTVYLFDQETP-TNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGF 1431



 Score = 39.7 bits (91), Expect = 0.026
 Identities = 34/104 (32%), Positives = 44/104 (42%), Gaps = 12/104 (11%)

Query: 424  PLAGRAGQSKISDPGPGPGGVGGAPLPPPGAPRSCIRIRARF-----PAPPAPPAPPPRG 478
            P A  AG+  +   G  P G G AP    G P S +  +A +     P PP PP PPP  
Sbjct: 1128 PRAPGAGRLDLGSGGRAPVGTGTAP---GGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPE 1184

Query: 479  PKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEG 522
             + +     P R   A    +P+GE   P  R      LS G+G
Sbjct: 1185 AQPRRLEPAPPR---ARPEVAPEGEPGAPDSRAGGDTALS-GDG 1224



 Score = 37.0 bits (84), Expect = 0.17
 Identities = 26/71 (36%), Positives = 30/71 (42%), Gaps = 4/71 (5%)

Query: 415 ADQESNISGPLAGRAGQSKISDPGPGPGGVG---GAPLPPPGA-PRSCIRIRARFPAPPA 470
           AD  ++   P A  +  S +S PGP PG  G     P  P GA P          P P A
Sbjct: 793 ADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRA 852

Query: 471 PPAPPPRGPKR 481
           PP PP  G  R
Sbjct: 853 PPEPPDPGAPR 863


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 100/399 (25%), Positives = 164/399 (41%), Gaps = 25/399 (6%)

Query: 128 TDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAV 187
           T+ V +L++KG          G  PL LAA   +   ++++L   G  LD +     TA+
Sbjct: 23  TENVVQLINKGA--RVAVTKHGRTPLHLAANKGHLP-VVQILLKAGCDLDVQDDGDQTAL 79

Query: 188 HCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITD 247
           H AT   N   +  L+  G + D +D  G T L H A   G +   +LL+   A +   +
Sbjct: 80  HRATVVGNTEIIAALIHEGCALDRQDKDGNTAL-HEASWHGFSQSAKLLVKAGANVLAKN 138

Query: 248 ENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGA 307
           + G   +H AC+  H Q    LL  G+    +N +G+T LH+ A YN  S  R+LL    
Sbjct: 139 KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFC 198

Query: 308 NRDVRNYNSQTAFQVAIIAGNFELAEV-IKTHKDSDVVPFRETPSYAKRRRLAGPSGLAS 366
           +   +N    TA  VA    + ++A++ ++   D+ +V              AG + L +
Sbjct: 199 SVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV------------NNAGQTPLET 246

Query: 367 PRPLQRSASDINLKGEAQPAA-SPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGPL 425
            R        + L    Q    S G SLR    +L  +R  +   RD  A  + ++S   
Sbjct: 247 ARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGD 306

Query: 426 AGRAGQSKISDPGPGPGGVGGAPLP-PPGAPRSCIRIRARFPAPPAPPAPPPRGPKRKLY 484
              + Q+           +  +P P      R   R +    + P PPA    G ++ L+
Sbjct: 307 TPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLH 366

Query: 485 SAVPGRKFIAVKAHSPQGEGEI------PLHRGEAVKVL 517
           +    +K    +  SP    E        L+RG+  KV+
Sbjct: 367 AHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVM 405



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 2/183 (1%)

Query: 155 LAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDS 214
           L A     T+ +  L N GA +   T+ G T +H A  + +   +  LL  G   D +D 
Sbjct: 15  LVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73

Query: 215 RGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGA 274
              T L+ + + G   +   L+ H+   L   D++G   +H+A   G  Q  + L+  GA
Sbjct: 74  GDQTALHRATVVGNTEIIAALI-HEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132

Query: 275 DMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEV 334
           ++ A+N +GNTALH+    +     RVLL  G+  D++N    T   VA    +  +  +
Sbjct: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192

Query: 335 IKT 337
           + T
Sbjct: 193 LLT 195


>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 65/200 (32%), Positives = 98/200 (49%), Gaps = 7/200 (3%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D +  LL + +D    D D G+  +  AA  D    +++VL  G A L+ R +   T +H
Sbjct: 478 DILKLLLKQNVDVEAEDKD-GDRAVHHAAFGDEGA-VIEVLHRGSADLNARNKRRQTPLH 535

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A  + +   + TLLD G  P  +DS G TPL H A+         +LL   A + IT+ 
Sbjct: 536 IAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPL-HDAISKKRDDILAVLLEAGADVTITNN 594

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGAD---MGAQNASGNTALHICALYNQESCARVLLFR 305
           NG+  +H A   G+   +  LL        +  +   G TALH+ AL N    A +L+ +
Sbjct: 595 NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQ 654

Query: 306 G-ANRDVRNYNSQTAFQVAI 324
           G AN D++N N QTA  +A+
Sbjct: 655 GNANLDIQNVNQQTALHLAV 674



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 53/162 (32%), Positives = 75/162 (46%), Gaps = 7/162 (4%)

Query: 131 VARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCA 190
           V  LLD G  P+  D + G+ PL  A       D+L VL   GA +     +G  A+H A
Sbjct: 546 VKTLLDFGCHPSLQDSE-GDTPLHDAIS-KKRDDILAVLLEAGADVTITNNNGFNALHHA 603

Query: 191 TRQRNAAALTTLLDLGASP---DYKDSRGLTPLYHSALGGGDALCCELLLHD-HAQLGIT 246
             + N +A+  LL     P   D K   G T L+ +AL     +  ELL+H  +A L I 
Sbjct: 604 ALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVA-ELLVHQGNANLDIQ 662

Query: 247 DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALH 288
           + N    +H A    H Q +  L+  GA +  Q+  G+T LH
Sbjct: 663 NVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLH 704



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 1/146 (0%)

Query: 183 GLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQ 242
           G TA+  A++  +   L  LL      + +D  G   ++H+A G   A+  E+L    A 
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVI-EVLHRGSAD 522

Query: 243 LGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVL 302
           L   ++     +H A   GH+Q ++ LL +G     Q++ G+T LH      ++    VL
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582

Query: 303 LFRGANRDVRNYNSQTAFQVAIIAGN 328
           L  GA+  + N N   A   A + GN
Sbjct: 583 LEAGADVTITNNNGFNALHHAALRGN 608



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 46/155 (29%), Positives = 68/155 (43%), Gaps = 15/155 (9%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKN-GGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDL 205
           D G   L LAA L+N  ++ ++L + G A+LD +  +  TA+H A  +++   +  L+  
Sbjct: 630 DDGYTALHLAA-LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRA 688

Query: 206 GASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFG-HVQ 264
           GA  D +D  G TPL H AL     L     L D   +G  D   W+        G   Q
Sbjct: 689 GAKLDIQDKDGDTPL-HEAL-RHHTLSQLRQLQDMQDVGKVDA-AWEPSKNTLIMGLGTQ 745

Query: 265 HLE---------HLLFYGADMGAQNASGNTALHIC 290
             E          L   GAD+  +N  G + L +C
Sbjct: 746 GAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC 780



 Score = 40.0 bits (92), Expect = 0.020
 Identities = 23/86 (26%), Positives = 43/86 (50%)

Query: 250 GWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANR 309
           G   +  A + GHV  L+ LL    D+ A++  G+ A+H  A  ++ +   VL    A+ 
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523

Query: 310 DVRNYNSQTAFQVAIIAGNFELAEVI 335
           + RN   QT   +A+  G+ ++ + +
Sbjct: 524 NARNKRRQTPLHIAVNKGHLQVVKTL 549


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 62/209 (29%), Positives = 96/209 (45%), Gaps = 11/209 (5%)

Query: 100 NLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQL 159
           N  D K    LH  A    +M ++     D VA L++ G +    D   G  PL  AA  
Sbjct: 142 NAFDKKDRRALHWAA----YMGHL-----DVVALLINHGAEVTCKDK-KGYTPLHAAAS- 190

Query: 160 DNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTP 219
           +   +++K L N G  +D     G TA+H A      A +  L+D GA+ +  ++ G TP
Sbjct: 191 NGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTP 250

Query: 220 LYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQ 279
           L+ +A     ALC ELL+++ A + I  ++G   +H     G     + L+  G ++   
Sbjct: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 310

Query: 280 NASGNTALHICALYNQESCARVLLFRGAN 308
           +  GNT LH+ A Y  E     L   GA+
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGAD 339



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 63/241 (26%), Positives = 98/241 (40%), Gaps = 39/241 (16%)

Query: 128 TDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAV 187
           +D   +LL  G + +  D     C  + AA      + +K+L++ GA    + + G T +
Sbjct: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAA--GGNVECIKLLQSSGADFHKKDKCGRTPL 417

Query: 188 HCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGD------------------ 229
           H A    +   + TL+  GA+ +  D  G T L+++A    D                  
Sbjct: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477

Query: 230 ---------ALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLL------FYGA 274
                     LC E LL + A   I D+ G+  IH A  +GH Q LE LL      F  +
Sbjct: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537

Query: 275 DMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEV 334
           D GA      + LH+ A         VLL    + D+R+   +TA  +A   G+ E  E 
Sbjct: 538 DSGAT----KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEA 593

Query: 335 I 335
           +
Sbjct: 594 L 594



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 55/190 (28%), Positives = 84/190 (44%), Gaps = 3/190 (1%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           L++ G D N    D G+ PL + A     T    +++NGG  +D   +DG T +H A R 
Sbjct: 267 LVNNGADVNIQSKD-GKSPLHMTAVHGRFTRSQTLIQNGG-EIDCVDKDGNTPLHVAARY 324

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQE 253
            +   + TL   GA         + PL+ +AL      CC  LL    ++   D+ G   
Sbjct: 325 GHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD-CCRKLLSSGFEIDTPDKFGRTC 383

Query: 254 IHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRN 313
           +H A   G+V+ ++ L   GAD   ++  G T LH  A      C   L+  GAN +  +
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443

Query: 314 YNSQTAFQVA 323
              +TA   A
Sbjct: 444 DWGRTALHYA 453



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 67/240 (27%), Positives = 104/240 (43%), Gaps = 15/240 (6%)

Query: 113 KANLKKFMDYVQLH------STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLL 166
           + N K  M    LH      S + V  L+    D N  D +  + PL +AA  + A    
Sbjct: 41  RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKN-WQTPLHVAAA-NKAVKCA 98

Query: 167 KVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASP---DYKDSRGLTPLYHS 223
           +V+    + ++   R G TA+H A    +   +  LL  GA+    D KD R L    H 
Sbjct: 99  EVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRAL----HW 154

Query: 224 ALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASG 283
           A   G      LL++  A++   D+ G+  +H A   G +  ++HLL  G ++   N  G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214

Query: 284 NTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDV 343
           NTALHI     Q++    L+  GAN +  N N  T    A  + +  L   +  +  +DV
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 59/237 (24%), Positives = 103/237 (43%), Gaps = 7/237 (2%)

Query: 122 YVQLHSTDKVARLLDKGLDPNFHDPDSG--ECPLSLAAQLDNATDLLKVLKNGGAHLDFR 179
           Y   +   +   LL +  +  F + DSG  + PL LAA  +     L+VL      LD R
Sbjct: 513 YAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAY-NGHHQALEVLLQSLVDLDIR 571

Query: 180 TRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLH- 238
              G TA+  A  + +   +  L++ GAS   KD+       H+++  G  LC  LLL  
Sbjct: 572 DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEI 631

Query: 239 --DHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQE 296
             +   + + D  G   +  A  +GH+  +  LL   A++   +  G TALH   +   E
Sbjct: 632 ADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHE 691

Query: 297 SCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFE-LAEVIKTHKDSDVVPFRETPSY 352
            C ++LL +  +   ++   +T    A   G+   L+E+++     +   F++   Y
Sbjct: 692 ECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 55/209 (26%), Positives = 87/209 (41%), Gaps = 6/209 (2%)

Query: 131 VARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCA 190
           V  L+D G + N    ++G  PL  AA   +    L++L N GA ++ +++DG + +H  
Sbjct: 230 VNELIDYGANVN-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288

Query: 191 TRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLH--DHAQLGITDE 248
                     TL+  G   D  D  G TPL+ +A  G + L   L     D A+ GI   
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGI--- 345

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
           +    +H A    H      LL  G ++   +  G T LH  A      C ++L   GA+
Sbjct: 346 HSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGAD 405

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVIKT 337
              ++   +T    A    +F   E + T
Sbjct: 406 FHKKDKCGRTPLHYAAANCHFHCIETLVT 434



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/154 (25%), Positives = 68/154 (44%), Gaps = 1/154 (0%)

Query: 185 TAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLG 244
           T +H A    +A  +  L+  GA  + KD+  LTPL H A+        ++L+   A + 
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPL-HRAVASRSEEAVQVLIKHSADVN 76

Query: 245 ITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLF 304
             D+N    +H A     V+  E ++   + +   +  G TALH  AL        +LL 
Sbjct: 77  ARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA 136

Query: 305 RGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTH 338
           +GAN +  +   + A   A   G+ ++  ++  H
Sbjct: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 1/123 (0%)

Query: 213 DSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFY 272
           DS   TPL H A   GDA   ELL+   A++   D      +H+A      + ++ L+ +
Sbjct: 13  DSEKRTPL-HVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKH 71

Query: 273 GADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELA 332
            AD+ A++ +  T LH+ A      CA V++   ++ +V +   +TA   A + G+ E+ 
Sbjct: 72  SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131

Query: 333 EVI 335
            ++
Sbjct: 132 NLL 134



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 53/192 (27%), Positives = 85/192 (44%), Gaps = 7/192 (3%)

Query: 149 GECPLSLAAQLDNATDLLKVLKNGGAHLD--FRTRDGLTAVHCATRQRNAAALTTLLDLG 206
           G  PL  AA   +AT L ++L+   +  D  F+   G T +H A    N   +  LL+  
Sbjct: 711 GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 770

Query: 207 ASPDYKDSRGLTPLYHSALGGGDALCCELLLH--DHAQLGITDENGWQEIHQACRFGHVQ 264
               +  +   TPL H A+      C  LLL   D + +   D+ G   +  A    HV+
Sbjct: 771 CFRKFIGNP-FTPL-HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVE 828

Query: 265 HLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRG-ANRDVRNYNSQTAFQVA 323
            L+ LL + A + A + SG TAL + A   Q     +L+    A+  V++ +  T   +A
Sbjct: 829 CLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLA 888

Query: 324 IIAGNFELAEVI 335
              G+ + A +I
Sbjct: 889 CSKGHEKCALLI 900


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 101/368 (27%), Positives = 147/368 (39%), Gaps = 46/368 (12%)

Query: 138  GLDPNFHDPDSGECPLSLAAQL---------------DNATDLLKVLKNGGAHLDFRT-R 181
            G+D N   PD G  PL LA+                 D +  ++  L   GA L  RT R
Sbjct: 1779 GMDVNVRGPD-GFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDR 1837

Query: 182  DGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHA 241
             G TA+H A R   A A   LLD GA  + +D  G TPL+ +       +   L+ +   
Sbjct: 1838 TGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRST 1897

Query: 242  QLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARV 301
             L     +G   +  A R      +E L+   AD+ A +  G +ALH  A  N       
Sbjct: 1898 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLA 1957

Query: 302  LLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGP 361
            LL  GAN+D+++   +T   +A   G++E A+++  H  +     RE   +  R     P
Sbjct: 1958 LLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFAN-----REITDHLDRL----P 2008

Query: 362  SGLASPRPLQRSASDINLKGEAQPAASPGP----SLRSLPHQLL--LQRLQEEKDRDRDA 415
              +A  R  Q       L   + P + PGP     L   P   L  L+  Q    + R  
Sbjct: 2009 RDVAQERLHQDIVR--LLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRP 2066

Query: 416  DQESNISGPLAGRAGQSKISDPGPGP---GGVGGAPLPPPGAPRSCIRIRARFPAPPAPP 472
              ++ + GP   R    K++   PGP     V  +P+    +PR        F  PPA P
Sbjct: 2067 PGKAGL-GPQGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRP-------FGGPPASP 2118

Query: 473  AP-PPRGP 479
               P  GP
Sbjct: 2119 GGFPLEGP 2126



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 46/152 (30%), Positives = 56/152 (36%), Gaps = 35/152 (23%)

Query: 129  DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLT--- 185
            D   RLLD G D N  D  SG  PL  A   D       +++N    LD R  DG T   
Sbjct: 1853 DAAKRLLDAGADTNAQD-HSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALI 1911

Query: 186  ------------------------------AVHCATRQRNAAALTTLLDLGASPDYKDSR 215
                                          A+H A    N  A   LL  GA+ D +DS+
Sbjct: 1912 LAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSK 1971

Query: 216  GLTPLYHSALGGGDALCCELLLHDHAQLGITD 247
              TPL+ +A  G      +LLL   A   ITD
Sbjct: 1972 EETPLFLAAREGSYE-AAKLLLDHFANREITD 2002


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 67/211 (31%), Positives = 103/211 (48%), Gaps = 5/211 (2%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           LL    D N  D    + PL +AA  + AT   + L    + L+   R G +A+H A   
Sbjct: 93  LLAHSADVNARDK-LWQTPLHVAAA-NRATKCAEALAPLLSSLNVADRSGRSALHHAVHS 150

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSA-LGGGDALCCELLLHDHAQLGITDENGWQ 252
            +   +  LL+ GAS +  D +   PL+ +A LG  + L  +LL+   A LG  D  G+ 
Sbjct: 151 GHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL--KLLVARGADLGCKDRKGYG 208

Query: 253 EIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVR 312
            +H A   G ++ +++LL  GA++   NA GNTALHI     Q++ A  L+  GAN +  
Sbjct: 209 LLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP 268

Query: 313 NYNSQTAFQVAIIAGNFELAEVIKTHKDSDV 343
           N    T   VA ++ N  L   +  +  +DV
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADV 299



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 11/228 (4%)

Query: 100 NLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQL 159
           N+ D K+   LH  A    F+ ++++     VAR  D G        D     L   A  
Sbjct: 167 NVCDKKERQPLHWAA----FLGHLEVLKL-LVARGADLGCK------DRKGYGLLHTAAA 215

Query: 160 DNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTP 219
               +++K L   GA +D     G TA+H A      A    L++ GA+ +  + +G TP
Sbjct: 216 SGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTP 275

Query: 220 LYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQ 279
           L+ +A+    ALC ELL+++ A +    + G   +H A   G     + L+  G+++   
Sbjct: 276 LHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA 335

Query: 280 NASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAG 327
           +  GNT LH+ A Y  E     L+  GA+   R  +      +A++ G
Sbjct: 336 DKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFG 383



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 67/252 (26%), Positives = 105/252 (41%), Gaps = 34/252 (13%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQ 193
           +L  G D N  D + G   L  AA   N  + L +L + GA L  R + G T +H A   
Sbjct: 409 VLSAGFDINTPD-NLGRTCLHAAASGGNV-ECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALG------------GGDA----------- 230
            +     TL+  GA  +  D +G +PL+++A                DA           
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRR 526

Query: 231 ----LCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLL--FYGADMGAQNASGN 284
                C E LL + A   + D  G+  +H A  +G+ Q+LE LL   +      ++    
Sbjct: 527 KEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPV 586

Query: 285 TALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVV 344
           + LH+ A        + L     N DVR++  +TA  +A   G+ E  EV+  H  S ++
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646

Query: 345 PFRE---TPSYA 353
             R+   TP +A
Sbjct: 647 KERKRKWTPLHA 658



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 63/236 (26%), Positives = 96/236 (40%), Gaps = 34/236 (14%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           ++V  LL +  + N  D +    PL  AA + +   +L++L   GA+++ +    LT +H
Sbjct: 22  EEVRSLLSQKENINVLDQER-RTPLHAAAYVGDVP-ILQLLLMSGANVNAKDTLWLTPLH 79

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLY--------------------------- 221
            A   RN   L  LL   A  + +D    TPL+                           
Sbjct: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139

Query: 222 -----HSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADM 276
                H A+  G      LLL+  A L + D+   Q +H A   GH++ L+ L+  GAD+
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199

Query: 277 GAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELA 332
           G ++  G   LH  A   Q    + LL  GA  D  N    TA  +A   G   +A
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVA 255



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 67/270 (24%), Positives = 110/270 (40%), Gaps = 31/270 (11%)

Query: 100 NLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQL 159
           N  +DK F  LH  A        V  +    +  L++ G D N+   + G+ PL +AA +
Sbjct: 266 NQPNDKGFTPLHVAA--------VSTNGALCLELLVNNGADVNYQSKE-GKSPLHMAA-I 315

Query: 160 DNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTP 219
                  ++L   G+ +D   + G T +H A R  +   ++TL+  GA    +    + P
Sbjct: 316 HGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFP 375

Query: 220 LYHSALGGGDALCCELLL-------------HDHA-----QLGITDENGWQEIHQACRFG 261
           L H A+  G + CC  LL             ++H       +   D  G   +H A   G
Sbjct: 376 L-HLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434

Query: 262 HVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQ 321
           +V+ L  LL  GAD+  ++  G T LH  A      CA  L+  GA  +  +    +   
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494

Query: 322 VAIIAGNFELAE--VIKTHKDSDVVPFRET 349
            A  +  +  AE     +H   +  P +E+
Sbjct: 495 YAAASDTYRRAEPHTPSSHDAEEDEPLKES 524



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 54/206 (26%), Positives = 93/206 (45%), Gaps = 15/206 (7%)

Query: 103 DDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDS-GECPLSLAAQLDN 161
           D K +  LHT A   +          + V  LL  G +    +P++ G   L +A  L  
Sbjct: 203 DRKGYGLLHTAAASGQI---------EVVKYLLRMGAE--IDEPNAFGNTALHIACYLGQ 251

Query: 162 ATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAA-ALTTLLDLGASPDYKDSRGLTPL 220
               ++++ N GA+++     G T +H A    N A  L  L++ GA  +Y+   G +PL
Sbjct: 252 DAVAIELV-NAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 221 YHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQN 280
           + +A+ G      ++L+ + +++   D+ G   +H A R+GH   +  L+  GAD   + 
Sbjct: 311 HMAAIHGRFTRS-QILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369

Query: 281 ASGNTALHICALYNQESCARVLLFRG 306
                 LH+  L+    C R LL  G
Sbjct: 370 IHDMFPLHLAVLFGFSDCCRKLLSSG 395



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 55/199 (27%), Positives = 85/199 (42%), Gaps = 7/199 (3%)

Query: 134 LLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHL-DFRTRDGLTAVHCATR 192
           LLD G DP+  D   G   +  AA   N  +L  +L+     L D  +   ++ +H A  
Sbjct: 536 LLDNGADPSLRDRQ-GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAY 594

Query: 193 QRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELL-LHDHAQLGITDENGW 251
             +  AL TL +   + D +D +G T L+  A   G   C E+L  H  + L    +  W
Sbjct: 595 NGHCEALKTLAETLVNLDVRDHKGRTALF-LATERGSTECVEVLTAHGASALIKERKRKW 653

Query: 252 QEIHQACRFGHVQHLEHLLFYG--ADM-GAQNASGNTALHICALYNQESCARVLLFRGAN 308
             +H A   GH   L  L+  G  AD+    +A G T L +  +     C  +LL +G+ 
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713

Query: 309 RDVRNYNSQTAFQVAIIAG 327
            D  +   +TA     + G
Sbjct: 714 ADAADLRGRTALHRGAVTG 732



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 57/181 (31%), Positives = 78/181 (43%), Gaps = 6/181 (3%)

Query: 152 PLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDY 211
           PL LAA  +   + LK L     +LD R   G TA+  AT + +   +  L   GAS   
Sbjct: 588 PLHLAAY-NGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646

Query: 212 KD-SRGLTPLYHSALGGGDALCCELLLHDHAQLGITD---ENGWQEIHQACRFGHVQHLE 267
           K+  R  TPL H+A   G      LL+    +  ITD     G   +  A   GHV  + 
Sbjct: 647 KERKRKWTPL-HAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705

Query: 268 HLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAG 327
            LL  G+   A +  G TALH  A+   E C   LL   A    R++  +T   +A   G
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765

Query: 328 N 328
           +
Sbjct: 766 H 766



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 59/207 (28%), Positives = 91/207 (43%), Gaps = 16/207 (7%)

Query: 135 LDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDG--LTAVHCATR 192
           LD G+D       SG  P+  A+   +  D L++L     H  F   +G   T +HCA  
Sbjct: 783 LDAGVDY------SGYSPMHWASYTGHE-DCLELLLE---HSPFSYLEGNPFTPLHCAVI 832

Query: 193 QRNAAALTTLLD-LGAS-PDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENG 250
               +    LL  LGA   + +D++G TPL H+A    +     +LL   A++  TD  G
Sbjct: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPL-HAAAFADNVSGLRMLLQHQAEVNATDHTG 891

Query: 251 WQEIHQACRFGHVQHLEHLLFYG-ADMGAQNASGNTALHICALYNQESCARVLLFRGANR 309
              +  A   G    +E LL+ G AD+   + + NTALH+      E CA ++L    + 
Sbjct: 892 RTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951

Query: 310 DVRNYNSQTAFQVAIIAGNFELAEVIK 336
            + N  +        IA    LA V++
Sbjct: 952 GLINATNSALQMPLHIAARNGLASVVQ 978



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 47/151 (31%), Positives = 65/151 (43%), Gaps = 4/151 (2%)

Query: 160 DNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTP 219
           D+ T++L +   G   ++ R   G T +H A    N + L  LL   A  +  D  G T 
Sbjct: 836 DSTTEML-LGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTA 894

Query: 220 LYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQ 279
           L  +A  G  A    LL    A L + DEN    +H AC  GH +    +L    D+G  
Sbjct: 895 LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954

Query: 280 NASGNT---ALHICALYNQESCARVLLFRGA 307
           NA+ +     LHI A     S  + LL  GA
Sbjct: 955 NATNSALQMPLHIAARNGLASVVQALLSHGA 985



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 63/231 (27%), Positives = 97/231 (41%), Gaps = 10/231 (4%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D V  LL+KG   +  D   G   L   A +    D L  L +  A +  R   G T +H
Sbjct: 702 DCVHLLLEKGSTADAADL-RGRTALHRGA-VTGCEDCLAALLDHDAFVLCRDFKGRTPIH 759

Query: 189 CATRQRNAAALTTLLDLGASPDYKDS----RGLTPLYHSALGGGDALCCELLLHDHAQLG 244
            A+   + A L TLL    S D  D+     G +P++ ++  G +  C ELLL +H+   
Sbjct: 760 LASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHED-CLELLL-EHSPFS 817

Query: 245 ITDENGWQEIHQACRFGHVQHLEHLL-FYGADM-GAQNASGNTALHICALYNQESCARVL 302
             + N +  +H A         E LL   GA +  +++A G T LH  A  +  S  R+L
Sbjct: 818 YLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRML 877

Query: 303 LFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYA 353
           L   A  +  ++  +TA   A   G     E +     +D+    E  + A
Sbjct: 878 LQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTA 928



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 1/142 (0%)

Query: 194 RNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQE 253
           R+   + +LL    + +  D    TPL H+A   GD    +LLL   A +   D      
Sbjct: 19  RDVEEVRSLLSQKENINVLDQERRTPL-HAAAYVGDVPILQLLLMSGANVNAKDTLWLTP 77

Query: 254 IHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRN 313
           +H+A    + + L  LL + AD+ A++    T LH+ A      CA  L    ++ +V +
Sbjct: 78  LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137

Query: 314 YNSQTAFQVAIIAGNFELAEVI 335
            + ++A   A+ +G+ E   ++
Sbjct: 138 RSGRSALHHAVHSGHLETVNLL 159



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 49/198 (24%), Positives = 80/198 (40%), Gaps = 10/198 (5%)

Query: 149 GECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGL-TAVHCATRQRNAAALTTLLDLGA 207
           G   L LA +   +T+ ++VL   GA    + R    T +H A    +  +L  L+D G 
Sbjct: 618 GRTALFLATER-GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGE 676

Query: 208 SPDYKD---SRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQ 264
             D  D   + G TPL   A+  G   C  LLL   +     D  G   +H+    G   
Sbjct: 677 RADITDVMDAYGQTPLM-LAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735

Query: 265 HLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVR----NYNSQTAF 320
            L  LL + A +  ++  G T +H+ +     +  R LL    + D      +Y+  +  
Sbjct: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795

Query: 321 QVAIIAGNFELAEVIKTH 338
             A   G+ +  E++  H
Sbjct: 796 HWASYTGHEDCLELLLEH 813



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 40/146 (27%), Positives = 61/146 (41%), Gaps = 4/146 (2%)

Query: 149  GECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGAS 208
            G  PL  AA  DN + L  +L++  A ++     G TA+  A      AA+  LL  G +
Sbjct: 858  GRTPLHAAAFADNVSGLRMLLQHQ-AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKA 916

Query: 209  PDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGI---TDENGWQEIHQACRFGHVQH 265
                         H A   G   C  ++L +   LG+   T+      +H A R G    
Sbjct: 917  DLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASV 976

Query: 266  LEHLLFYGADMGAQNASGNTALHICA 291
            ++ LL +GA + A +  G+T    CA
Sbjct: 977  VQALLSHGATVLAVDEEGHTPALACA 1002


>gi|110431370 espin [Homo sapiens]
          Length = 854

 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 82/345 (23%), Positives = 138/345 (40%), Gaps = 39/345 (11%)

Query: 147 DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLL-DL 205
           D G  P+  AA   +   L  ++++    ++ +T++G T ++ A ++ +      L+ + 
Sbjct: 136 DMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQEC 195

Query: 206 GASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQH 265
           GA P  +   G+TPL+ +A  G   +   L+      L   D++G   +H A   GH + 
Sbjct: 196 GADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKV 255

Query: 266 LEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAII 325
           L  LL +G ++ A +  G T LH  A   +  C ++L+  GA  DVR+ +  TA  ++  
Sbjct: 256 LSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDF 314

Query: 326 AGNFELAEVIKT-------HKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRS-ASDI 377
            G+      ++T       H+     P  E  +      ++ P+   S +PL    +S  
Sbjct: 315 NGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPT 374

Query: 378 NLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISDP 437
           +        +S   S++       L        R  D     ++  P  G          
Sbjct: 375 STLSNYDSCSSSHSSIKGQHPPCGL-----SSARAADIQSYMDMLNPELGL--------- 420

Query: 438 GPGPGGVGGAPLPPPGAPRSCIRIRARFPAPPAPPA----PPPRG 478
              P G  G P PPP  P         FP PP PP     PPP G
Sbjct: 421 ---PRGTIGKPTPPPPPP--------SFPPPPPPPGTQLPPPPPG 454



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 100/415 (24%), Positives = 147/415 (35%), Gaps = 89/415 (21%)

Query: 830  PPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEP 889
            PPPP + PPPPP        PP    PPPPPG           P  +  +G  AA +Y  
Sbjct: 431  PPPPPSFPPPPP--------PPGTQLPPPPPG----------YPAPKPPVGPQAADIYM- 471

Query: 890  GAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPPGPDSPYAN 949
                  L + E +   + +     S+ +  D  R   ++    +P+   + P     Y  
Sbjct: 472  -QTKNKLRHVETEALKKEL-----SSCDGHDGLRRQDSS---RKPRAFSKQPSTGDYYRQ 522

Query: 950  LGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSP--GPGG-GSFAREPSPTHR 1006
            LG       A ++P    S        E+ + R     G P  GP   GS     +P   
Sbjct: 523  LGRCPGETLA-ARPGMAHS--------EEVRARQPARAGCPRLGPAARGSLEGPSAPPQA 573

Query: 1007 GPRPGG-LDYGAGDGPGLA--FGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSL 1063
               PG  +  G    P  +     P P     L E   S            AP   L S 
Sbjct: 574  ALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASS---------PPPAPPLPLESA 624

Query: 1064 QPSRSIDERLLGTGPTAGRDLLLPSPVSA--LKPLVSGPSLGPS----GSTFIHPLTGKP 1117
             P          TG T   +++ P+  ++  L  + +G SL P+    G T +    G+P
Sbjct: 625  GPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQP 684

Query: 1118 -LDPSSPLALALAARERALASQAPSRSPTPVHS--------------PDADRPGPLFVDV 1162
               P SPL     A        +P RSPTP  +              P    PG + +DV
Sbjct: 685  AFQPDSPLPSVSPA-------LSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPG-VQLDV 736

Query: 1163 QARDPERGSLASPAFSPRSPAW-IPVPARREAEKVPREE--RKSPEDKKSMILSV 1214
            +A  P       P      P W   V  R+   K+  EE  R+  E++++ + S+
Sbjct: 737  EALIPTHDEQGRPI-----PEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASM 786



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 2/146 (1%)

Query: 148 SGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGA 207
           +G  P   A+   +   L  +L  GG  +  +   G T +H A R  +   +  LL  G 
Sbjct: 69  NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128

Query: 208 S-PDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHL 266
             P      G  P++++A  G       L+ H    +    +NG   ++ AC+ GH++  
Sbjct: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188

Query: 267 EHLL-FYGADMGAQNASGNTALHICA 291
           ++L+   GAD  A+   G T LH  A
Sbjct: 189 QYLVQECGADPHARAHDGMTPLHAAA 214



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 54/190 (28%), Positives = 77/190 (40%), Gaps = 12/190 (6%)

Query: 154 SLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA--VHCATRQRNAAALTTLLDLGASPDY 211
           +L A      D+L+ L   G  L    RD L A  VH A R      L  L++  A P  
Sbjct: 6   ALQAARQGELDVLRSLHAAGL-LGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAA 64

Query: 212 KDSR-GLTPLYHSALGGGDALCCELLLHDHA-QLGITDENGWQEIHQACRFGHVQHLEHL 269
             +R G TP  H A   G   C + LL     ++   D +G   +H A RFGH + +  L
Sbjct: 65  ARARNGATPA-HDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWL 123

Query: 270 LFY-GADMGAQNASGNTALHICALYNQESCARVLLF---RGANRDVRNYNSQTAFQVAII 325
           L + G D  A    G   +H  A        R+L+     G N   +  N  T   +A  
Sbjct: 124 LHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTK--NGATPLYLACQ 181

Query: 326 AGNFELAEVI 335
            G+ E+ + +
Sbjct: 182 EGHLEVTQYL 191



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 70/272 (25%), Positives = 102/272 (37%), Gaps = 36/272 (13%)

Query: 694 PPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAA-AEPTLRPDIADADSR 752
           PPPP   P+    +  ++    ++    +R  + E L + L++      LR   +    R
Sbjct: 449 PPPPPGYPAPKPPVGPQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDSSRKPR 508

Query: 753 AATVKQRPTS---RRITPAEISSLFERQGLPGPEKLPGS--LRKGIPRTKSVGEDE---- 803
           A + KQ  T    R++      +L  R G+   E++      R G PR            
Sbjct: 509 AFS-KQPSTGDYYRQLGRCPGETLAARPGMAHSEEVRARQPARAGCPRLGPAARGSLEGP 567

Query: 804 ---KLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPP- 859
                A+LL G    +    DP       PPPP   PP P A     S PPPA  PP P 
Sbjct: 568 SAPPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAA----SSPPPA--PPLPL 621

Query: 860 ----PG----RAYDTVRSSFKPGLEARLGAGAAGLYE--PGAALGPLPYPERQKRARSMI 909
               PG    R+  +  S+    + +  G  +  L E   G +L P P  +      S I
Sbjct: 622 ESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGI 681

Query: 910 ILQDSAPESGDAPRPPPAATPPERPKRRPRPP 941
                 P+S     P P+ +P   P R P PP
Sbjct: 682 GQPAFQPDS-----PLPSVSPALSPVRSPTPP 708



 Score = 35.4 bits (80), Expect = 0.49
 Identities = 90/412 (21%), Positives = 136/412 (33%), Gaps = 65/412 (15%)

Query: 1324 PPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRSSSD 1383
            PPP  F            P P  T +P P  G P+ +PP  P++A              D
Sbjct: 432  PPPPSFP---------PPPPPPGTQLPPPPPGYPAPKPPVGPQAA--------------D 468

Query: 1384 PHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPV 1443
             +++T + +  V +         E      S  DGH   L +     KP+  S       
Sbjct: 469  IYMQTKNKLRHVET---------EALKKELSSCDGHDG-LRRQDSSRKPRAFS------- 511

Query: 1444 TFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWG----DPVESRGL 1499
                   KQ S  +   Q        LA+  G A    +  R+    G     P     L
Sbjct: 512  -------KQPSTGDYYRQLGRCPGETLAARPGMAHSEEVRARQPARAGCPRLGPAARGSL 564

Query: 1500 PGPEDDKPTVI---SELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSL 1556
             GP       +   + + +      K +R L   P      L + A   P A      S 
Sbjct: 565  EGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESA 624

Query: 1557 GELSSISAQRSPGGPGGGASYS-VRPSG---RYPVARRAPSPVKPASLERVEGLGAGAGG 1612
            G       +RS    G   S++ + P+G         +A   +KP    + +GL     G
Sbjct: 625  G--PGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPT--PQSKGLTTVFSG 680

Query: 1613 AGRP-FGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPG 1671
             G+P F    P    S +LS    P       + +   S  P P   P+P       A  
Sbjct: 681  IGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQLDVEALI 740

Query: 1672 PRRPFQQKPLQLWSKFDV--GDWLESIHLGEHRDRFEDHEIEGAHLPALTKD 1721
            P    Q +P+  W +  +     L+     E R + E+ E   A +PA  +D
Sbjct: 741  PTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWRRD 792



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 29/104 (27%), Positives = 35/104 (33%), Gaps = 14/104 (13%)

Query: 397 PHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISDPGPGPGGVGGAPLPPPGAPR 456
           P + L  R       +  A Q +    P  G A +  +  P   P     A LP    P 
Sbjct: 527 PGETLAARPGMAHSEEVRARQPARAGCPRLGPAARGSLEGPSAPPQA---ALLPGNHVPN 583

Query: 457 SCI---RIRARFPAPPAPPAP--------PPRGPKRKLYSAVPG 489
            C    +     P PP PP P        PP  P   L SA PG
Sbjct: 584 GCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPG 627


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 54/183 (29%), Positives = 92/183 (50%), Gaps = 3/183 (1%)

Query: 153 LSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYK 212
           L +AA   +   L+ +LK G A+ +++   G T +H A R      ++ LL+  A  +  
Sbjct: 69  LHIAANCGSVECLVLLLKKG-ANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNIC 127

Query: 213 DSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFY 272
           ++ GLT ++  A+ G   L  +L+ H  + + + D  G   +H AC+ GH   ++ LL  
Sbjct: 128 NNEGLTAIHWLAVNGRTELLHDLVQHV-SDVDVEDAMGQTALHVACQNGHKTTVQCLLDS 186

Query: 273 GADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELA 332
           GAD+   N SG T L+    + Q   A++LL RGA + + + N  T   + +  G  E  
Sbjct: 187 GADINRPNVSGATPLYFACSHGQRDTAQILLLRGA-KYLPDKNGVTPLDLCVQGGYGETC 245

Query: 333 EVI 335
           EV+
Sbjct: 246 EVL 248



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 37/119 (31%), Positives = 51/119 (42%)

Query: 210 DYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHL 269
           +Y   R    L H A   G   C  LLL   A     D +G   +H A R G  + +  L
Sbjct: 58  NYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKL 117

Query: 270 LFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
           L Y AD+   N  G TA+H  A+  +      L+   ++ DV +   QTA  VA   G+
Sbjct: 118 LEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGH 176



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 31/91 (34%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 254 IHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRN 313
           +H A   G V+ L  LL  GA+   Q+ SG T LH+ A   Q+ C   LL   A+ ++ N
Sbjct: 69  LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICN 128

Query: 314 YNSQTAFQVAIIAGNFELAEVIKTH-KDSDV 343
               TA     + G  EL   +  H  D DV
Sbjct: 129 NEGLTAIHWLAVNGRTELLHDLVQHVSDVDV 159


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 166/661 (25%), Positives = 220/661 (33%), Gaps = 140/661 (21%)

Query: 780  PGPEKLPGSLRKGIPRTKSVGED---EKLASLLEGRFPRSTSMQDPVR------EGRG-- 828
            P P   P +LR  +    +VG     E+   +     P S     P R       GRG  
Sbjct: 35   PPPPVTPAALRV-LGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGER 93

Query: 829  IPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGR------AYDTVRSSFKPGLEARLGAG 882
             PP   T+P P  +P     G     + P P G+      A +TV          R    
Sbjct: 94   APPAKNTSPGPVSSP-----GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS 148

Query: 883  AAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPP- 941
            A    +        P P   +R+R+      +  E G  PRP P+A        RPRPP 
Sbjct: 149  AGARRDTSGPTPGTPSPAMARRSRA------AGTEVG-LPRPAPSA--------RPRPPT 193

Query: 942  -GPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFARE 1000
             GP    ++    S +  +P+  +R  +    Q     +   +A  + SP   G S    
Sbjct: 194  EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 253

Query: 1001 P-SPTHRG-PRPGGLDYGAGDGPGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGA 1058
            P +P H   P+P GL          A   P     R+           ++G +  S    
Sbjct: 254  PRAPAHPSQPKPKGLQ---------ALRPPQVTPPRK-------DAAPALGPLSSSPLAT 297

Query: 1059 DLPSLQPSRSIDERL-----------------LGTGPTAGRDLLLPSPVSALKPLVSGPS 1101
              PS  PS S    L                 LG+         LPSP   L PL + P 
Sbjct: 298  PSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSP--PLSPLATPPP 355

Query: 1102 LGPSGSTFIHPLTGKPLDPSSP----LALALAARERALAS---QAPSRSPT--PVHSPDA 1152
              P     + PL   P  P+SP    LA        ALA    QAP   P   PV +P +
Sbjct: 356  QAPPALA-LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS 414

Query: 1153 DRPGPLFVDVQARDPERG--SLASP---------AFSPRSPAWIPVP-ARREAEKVPREE 1200
                P  V   A  P +   SLA+P         A  P SP+  P P A       P + 
Sbjct: 415  PPASPP-VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 473

Query: 1201 RKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQS 1260
             K P      + +    +L  P       A+  GQ P          P +P   P P   
Sbjct: 474  AKPPPQAPPALATPPLQALPSPP------ASFPGQAPF---SPSASLPMSPLATPPPQAP 524

Query: 1261 AAVAEPL----PSPRAQPPGGTPA-DAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETRE 1315
              +A PL    PSP A P    P     PG  +S   P L  A+   P            
Sbjct: 525  PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPP----------- 573

Query: 1316 ELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVP-------SPASGKPSSEPPPAPESA 1368
                    PPP    +  L    LAG   S T+ P       S   G  ++ PPP  E A
Sbjct: 574  --------PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA 625

Query: 1369 A 1369
            A
Sbjct: 626  A 626



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 146/576 (25%), Positives = 204/576 (35%), Gaps = 92/576 (15%)

Query: 917  ESGDAPRPPPAATP---PERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQ 973
            ++G A R P A  P     RP   PRPP P +P A L    A+     KP   ++  +  
Sbjct: 9    KAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAA-LRVLGAAGAVGRKPLAERAGGIGG 67

Query: 974  LQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGG--PGPA 1031
              + ++  RA     S  P  G   R P   +  P P          PG A G   PGP 
Sbjct: 68   ATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVS-------SPGRASGTTRPGPL 120

Query: 1032 KDRRLEERRRSTVF------------LSVGA---IEGSAPGADLPSLQPSRSIDERLLGT 1076
              + L      TV             LS GA     G  PG       PS ++  R    
Sbjct: 121  GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGT------PSPAMARRSRAA 174

Query: 1077 GPTAGRDLLLPSPVSALKPLVSGP-----------SLGPSGSTFIHPLTGKPLDPSSPLA 1125
            G   G  L  P+P +  +P   GP           +  PS +    P  G  L    P +
Sbjct: 175  GTEVG--LPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ--RPAS 230

Query: 1126 LALAARERALASQA---PSRSPTPVHSPDADRPGPLFVDV----QARDPERGSLASPAFS 1178
             +L++    L+S A   PS   TP       +P P  +      Q   P +   A+PA  
Sbjct: 231  RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD--AAPALG 288

Query: 1179 P--RSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQE 1236
            P   SP   P P+   +   P   +  P    +   S   TSL  P  L   H+      
Sbjct: 289  PLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPP-SQATTSLGSPT-LQATHSFLPSPP 346

Query: 1237 PSRLGGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQPPGG---TPADAGPG-------Q 1286
             S L     + P  P LA  P+Q+       PSP A PP     TP+   P        Q
Sbjct: 347  LSPLATPPPQAP--PALALPPLQAP------PSPPASPPLSPLATPSPQAPNALAVHLLQ 398

Query: 1287 GSSEEEPEL-VFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPS 1345
                  P   V A   PPA    S   T    A   L  PP +       + P++     
Sbjct: 399  APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 458

Query: 1346 PTTVPSPASGKP---SSEPPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLS 1402
            P   P P +  P   +  PP AP + A   ++   +  +S P     S  +++  MS L+
Sbjct: 459  PPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL-PMSPLA 517

Query: 1403 SESGELTDTHTSFADGHTFLLEKPPVPP-KPKLKSP 1437
            +   +      +       LL+ PP PP  P L++P
Sbjct: 518  TPPPQAPPVLAA------PLLQVPPSPPASPTLQAP 547



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 200/857 (23%), Positives = 275/857 (32%), Gaps = 155/857 (18%)

Query: 802  DEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPG 861
            D K      G   R+ + + P   G   P PP +  PPPP         P A       G
Sbjct: 2    DNKRDKAKAGAAARTPAARAP---GLLTPRPPGSPRPPPPV-------TPAALRVLGAAG 51

Query: 862  RAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDA 921
                      KP  E   G G A + E     G    P R  R           P SG  
Sbjct: 52   AV------GRKPLAERAGGIGGATIPESAPRAG----PTRTSR----------PPASGRG 91

Query: 922  PRPPPAATPPERPKRRP-RPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQ 980
             R PPA      P   P R  G   P   LG     + A     R K+         +A 
Sbjct: 92   ERAPPAKNTSPGPVSSPGRASGTTRP-GPLGQKGLRISAEETVARGKA--------TEAP 142

Query: 981  ERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGPGPAKDRRLEERR 1040
            +R+AL+ G+     G     P+P    P        AG   GL    P  A+ R   E  
Sbjct: 143  KRSALSAGARRDTSG-----PTPGTPSPAMARRSRAAGTEVGLPRPAPS-ARPRPPTEGP 196

Query: 1041 RSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLP-------SPVSAL 1093
            R +V          +  ++  + +PS +   R     P+AG  L  P       S     
Sbjct: 197  RKSV----------SSASEHSTTEPSPAARRR-----PSAGGGLQRPASRSLSSSATPLS 241

Query: 1094 KPLVSGPSLGPSGSTFIHPLTGKP--LDPSSPLALALAARERALA----SQAPSRSPTPV 1147
             P  SGPS   +     HP   KP  L    P  +    ++ A A    S +P  +P+P 
Sbjct: 242  SPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS 301

Query: 1148 HSPDADRPGPL--FVDVQARDPERG--SLASPAFS---------PRSPAWIPVPARREAE 1194
              P    P  L       A  P +   SL SP            P SP   P P    A 
Sbjct: 302  APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 361

Query: 1195 KVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSN--GQEPSRLGGAEEERPGTPE 1252
             +P   +  P    S  LS L T   +    + VH         PS    A    P +P 
Sbjct: 362  ALP-PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 420

Query: 1253 LAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEE 1312
            ++P+    +     L +P  Q P   PA + P   S+   P+    +  PP QL+    +
Sbjct: 421  VSPSATPPSQAPPSLAAPPLQVPPSPPA-SPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479

Query: 1313 TREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSG 1372
                LA     PP +      L + P + PG +P +  +     P + PPP       + 
Sbjct: 480  APPALA----TPPLQ-----ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAP 530

Query: 1373 VEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKP 1432
            + +      + P L+      T    +++S               G    L   P PP P
Sbjct: 531  LLQVPPSPPASPTLQAPRRPPTPGPDTSVS---------------GPRLTLALAPGPPPP 575

Query: 1433 KLKSPLG--KGPVTFRDPLLKQSSDSELMAQQHHAASAGL--ASAAGPARPRYLFQRRSK 1488
              +SP     GP      L   SS +    ++     +G    +AA P     L      
Sbjct: 576  PSRSPSSTLSGP-----DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA 630

Query: 1489 LW----GDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKK 1544
             W      P+  RG PG     P      S+    L     + G E        LDP   
Sbjct: 631  AWSRGPAPPLAFRGAPGAPLPWPPATGPGSA--DGLCTIYETEGPESATPAPGALDP--- 685

Query: 1545 SPIAAARLFSSLGELSSISAQRSPGGPGGGASYSVRPS----GRYPVARRAPSPV----- 1595
                        G     S  ++  G G GAS S  P     G  P+     S V     
Sbjct: 686  ------------GPSPGTSGGKAAAGAGAGAS-SRSPKQARLGELPLGALQASVVQHLLS 732

Query: 1596 KPASLERVEGLGAGAGG 1612
            +   L   EG   G+GG
Sbjct: 733  RTLLLAAAEGAAGGSGG 749



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 178/760 (23%), Positives = 248/760 (32%), Gaps = 139/760 (18%)

Query: 688  GARRRAPPPPKRAPSTTLTLRSKSMTAEL---EELASIRRR---KGEKLDEMLAAAAEPT 741
            GARR    P    PS  +  RS++   E+       S R R   +G +     A+    T
Sbjct: 150  GARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT 209

Query: 742  LRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGE 801
                 A     A    QRP SR ++ +          L  P +  G   +G PR  +   
Sbjct: 210  EPSPAARRRPSAGGGLQRPASRSLSSSATP-------LSSPAR-SGPSARGTPRAPAHPS 261

Query: 802  DEKLASLLEGRFPRSTSMQDPVREGRG------IPPPPQTAPPPPPAPYYFDSGPPPAFS 855
              K   L   R P+ T  +       G      +  P  +APP P AP    + P P   
Sbjct: 262  QPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP--- 318

Query: 856  PPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSA 915
            P  PP +A  ++ S   P L+A         + P   L PL  P  Q    ++ +    A
Sbjct: 319  PATPPSQATTSLGS---PTLQATHS------FLPSPPLSPLATPPPQAPP-ALALPPLQA 368

Query: 916  PESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRK------SP 969
            P       P P A+PP  P   P P  P++   +L    A    P  P  +       SP
Sbjct: 369  P-------PSPPASPPLSPLATPSPQAPNALAVHL--LQAPFSPPPSPPVQAPFSPPASP 419

Query: 970  LVKQLQVEDAQERAALA-----VGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLA 1024
             V       +Q   +LA     V    P     +   +P  + P P          P L 
Sbjct: 420  PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA-------APPLQ 472

Query: 1025 FGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDL 1084
               P P     L       +     +  G AP        PS S+    L T P      
Sbjct: 473  LAKPPPQAPPALATPPLQALPSPPASFPGQAP------FSPSASLPMSPLATPPPQ---- 522

Query: 1085 LLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSP 1144
               +P     PL+  P   P+      P    P  P +P      +  R   + AP   P
Sbjct: 523  ---APPVLAAPLLQVPPSPPAS-----PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 574

Query: 1145 TPVHSPDADRPGPLFV-----------DVQARD--PERGSLASPAFSPRSPAWIPVPARR 1191
             P  SP +   GP              +++  D  PE G+ ASP       A  P  A  
Sbjct: 575  PPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA-AWS 633

Query: 1192 EAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTP 1251
                 P   R +P                  A L    AT  G         E E P + 
Sbjct: 634  RGPAPPLAFRGAP-----------------GAPLPWPPATGPGSADGLCTIYETEGPESA 676

Query: 1252 ELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDE 1311
              AP  +      +P PSP      G  A AG G G+S   P+      LP   L +S  
Sbjct: 677  TPAPGAL------DPGPSPGT---SGGKAAAGAGAGASSRSPKQARLGELPLGALQAS-- 725

Query: 1312 ETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADS 1371
              +  L+R  L+   E  A G       +G GP          G            AA S
Sbjct: 726  VVQHLLSRTLLLAAAEGAAGG-------SGGGPGGAEGGGVTGG----------ARAALS 768

Query: 1372 GVEEADTRSSSDPHLETTSTISTVSSMS--TLSSESGELT 1409
              E         P  E+ ++I++V+S S   ++S  G+ T
Sbjct: 769  DAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWT 808



 Score = 38.9 bits (89), Expect = 0.044
 Identities = 101/459 (22%), Positives = 140/459 (30%), Gaps = 91/459 (19%)

Query: 1242 GAEEERPGTPELAPAPMQSAAVAEPL--PSPRAQPPGGTPADAGPGQGSSEEEPELVFAV 1299
            G  E  P     +P P+ S   A     P P  Q      A+    +G + E P+     
Sbjct: 89   GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPK----- 143

Query: 1300 NLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSS 1359
                 + + S    R+        P P          T +  P P+P+  P P +  P  
Sbjct: 144  -----RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK 198

Query: 1360 EPPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTH-TSFADG 1418
                A E +       A  R S+   L+  ++ S  SS + LSS +        T  A  
Sbjct: 199  SVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 258

Query: 1419 HTFLLEKPPVPPKPK----LKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAA 1474
            H       P  PKPK    L+ P    P     P L   S S L             S +
Sbjct: 259  H-------PSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL----------ATPSPS 301

Query: 1475 GPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGG 1534
             P  P             P   + LP P    P             ++ T SLG   +  
Sbjct: 302  APPSP-----------SAPPSLQTLPSPPATPP-------------SQATTSLGSPTLQA 337

Query: 1535 LGSLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGPGGGASYS--VRPSGRYPVARR-- 1590
              S L     SP+A            ++   ++P  P      S    PS + P A    
Sbjct: 338  THSFLPSPPLSPLATPP--PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395

Query: 1591 ------APSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVR 1644
                  +P P  P               +  P    PP+ L +  L +P           
Sbjct: 396  LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS-LAAPPLQVP----------- 443

Query: 1645 SVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKPLQL 1683
                   SP  SP  SP++ P P AP    P    PLQL
Sbjct: 444  ------PSPPASPPMSPSATPPPQAP---PPLAAPPLQL 473



 Score = 35.4 bits (80), Expect = 0.49
 Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 7/94 (7%)

Query: 1584 RYPVARRAPSPVKPASLERVEGLGAGAGG----AGRPFGLTPPTILKSSSLSIPHEPKEV 1639
            R P + R P PV PA+L RV G  AGA G    A R  G+   TI +S+  + P      
Sbjct: 28   RPPGSPRPPPPVTPAAL-RVLG-AAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP 85

Query: 1640 RFVVRSVSA-RSRSPSPSPLPSPASGPGPGAPGP 1672
                R   A  +++ SP P+ SP    G   PGP
Sbjct: 86   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 119



 Score = 35.0 bits (79), Expect = 0.64
 Identities = 42/168 (25%), Positives = 55/168 (32%), Gaps = 47/168 (27%)

Query: 357 RLAGPSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDAD 416
           R+ G +G    +PL   A  I      + A   GP+  S P             R   A 
Sbjct: 45  RVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP---------PASGRGERAP 95

Query: 417 QESNIS-GPLAGRAGQSKISDPGP--------------GPGGVGGAPL------------ 449
              N S GP++     S  + PGP                G    AP             
Sbjct: 96  PAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDT 155

Query: 450 --PPPGAPRSCIRIRARF---------PAPPAPPAPPPRGPKRKLYSA 486
             P PG P   +  R+R          PAP A P PP  GP++ + SA
Sbjct: 156 SGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSA 203



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 43/172 (25%), Positives = 58/172 (33%), Gaps = 44/172 (25%)

Query: 350 PSYAKRRRLAGPSGLASP--RPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQE 407
           PS A RRR +   GL  P  R L  SA+ ++    + P+A   P   + P Q   + LQ 
Sbjct: 211 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA 270

Query: 408 EKDRDRDADQESNISGPLAGRAGQSKISDPGPGPGGVGGAP-----LP-PPGAPRSCIRI 461
            +       ++   + P  G    S ++ P P       AP     LP PP  P S    
Sbjct: 271 LRPPQVTPPRKD--AAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATT 328

Query: 462 RARFP----------------------------------APPAPPAPPPRGP 479
               P                                  APP+PPA PP  P
Sbjct: 329 SLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP 380



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 36/130 (27%), Positives = 46/130 (35%), Gaps = 17/130 (13%)

Query: 361 PSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESN 420
           P  LA P PLQ   S         P A+P P     P+ L +  LQ           ++ 
Sbjct: 358 PPALALP-PLQAPPSP-PASPPLSPLATPSPQA---PNALAVHLLQAPFSPPPSPPVQAP 412

Query: 421 ISGPLAGRAGQSKISDPGPGPGGVGGAPLP-PPGAPRSCIRIRARFPAPPAPP------- 472
            S P +     S  + P   P  +   PL  PP  P S     +  P P APP       
Sbjct: 413 FSPPASPPVSPSA-TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 471

Query: 473 ---APPPRGP 479
               PPP+ P
Sbjct: 472 QLAKPPPQAP 481


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 47/173 (27%), Positives = 86/173 (49%), Gaps = 3/173 (1%)

Query: 165 LLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLD--LGASPDYKDSRGLTPLYH 222
           +L++L N GA +   ++DGLT +HCA ++ +   L  +++     + D+ D  G T  +H
Sbjct: 106 ILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTA-FH 164

Query: 223 SALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNAS 282
            A   G     + L+       + D+ G   +H A   GH+  L+ L+  G D+  QNA 
Sbjct: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224

Query: 283 GNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
           G TALH  A  +   C ++LL  G+  +     + +    A ++G+ +++ V+
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVL 277



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 54/207 (26%), Positives = 100/207 (48%), Gaps = 3/207 (1%)

Query: 129 DKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
           D +  L+  G D N  D + G   L LAA   +   +L+ L + G  L+ +  +GLTA+H
Sbjct: 173 DALDFLVGSGCDHNVKDKE-GNTALHLAAGRGHMA-VLQRLVDIGLDLEEQNAEGLTALH 230

Query: 189 CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
            A    +   +  LL  G++ +    + L+ L+++AL G + +   +L+H      + D 
Sbjct: 231 SAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVS-RVLIHAGGCANVVDH 289

Query: 249 NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
            G   +H A R      +  L+   +D+ A +    T LH+ A +  +  A +LL  G +
Sbjct: 290 QGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVD 349

Query: 309 RDVRNYNSQTAFQVAIIAGNFELAEVI 335
            ++R+   +TA  VA+ + +  L ++I
Sbjct: 350 LNLRDKQGKTALAVAVRSNHVSLVDMI 376



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 40/171 (23%), Positives = 72/171 (42%), Gaps = 3/171 (1%)

Query: 133 RLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATR 192
           RL+D GLD    + + G   L  AA   +  D +++L   G+ ++  T+  L+ +H A  
Sbjct: 210 RLVDIGLDLEEQNAE-GLTALHSAAG-GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAAL 267

Query: 193 QRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQ 252
             +      L+  G   +  D +G +PL H A+         LL++  + +   D     
Sbjct: 268 SGSEDVSRVLIHAGGCANVVDHQGASPL-HLAVRHNFPALVRLLINSDSDVNAVDNRQQT 326

Query: 253 EIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLL 303
            +H A         + LL  G D+  ++  G TAL +    N  S   +++
Sbjct: 327 PLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 31/115 (26%), Positives = 46/115 (40%), Gaps = 11/115 (9%)

Query: 187 VHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGIT 246
           +H A RQ N   +  L+    +   ++  G   L H A G G      LLL   A +   
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVAL-HWAAGAGHEQAVRLLLEHEAAVDEE 77

Query: 247 DENGWQEIHQACR----------FGHVQHLEHLLFYGADMGAQNASGNTALHICA 291
           D  G     + C           FGH++ L+ L+  GA +  ++  G T LH  A
Sbjct: 78  DAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAA 132


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 57/169 (33%), Positives = 82/169 (48%), Gaps = 3/169 (1%)

Query: 169  LKNGGAHLDFRT-RDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGG 227
            L +GGA     T   G T +H A R     A   LL+ GA+P+  D  G TPL H+A+  
Sbjct: 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPL-HAAVAA 1677

Query: 228  GDALCCELLLHDH-AQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTA 286
                 C+LLL      +    E+G   +  A R      +E L+   AD+GA++  G TA
Sbjct: 1678 DAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTA 1737

Query: 287  LHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVI 335
            LH  A  N    AR LL  GA++D ++   QT   +A   G  E+A+++
Sbjct: 1738 LHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLL 1786



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 38/104 (36%), Positives = 54/104 (51%), Gaps = 2/104 (1%)

Query: 147  DSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLG 206
            + G  PL LAA+L    DL++ L    A +  R + G TA+H A    NA A  +LL  G
Sbjct: 1699 EDGTTPLMLAARLA-VEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAG 1757

Query: 207  ASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENG 250
            A  D +D+R  TPL+ +A  G   +  +LLL   A   + D+ G
Sbjct: 1758 ADKDAQDNREQTPLFLAAREGAVEV-AQLLLGLGAARELRDQAG 1800



 Score = 33.5 bits (75), Expect = 1.9
 Identities = 36/135 (26%), Positives = 57/135 (42%), Gaps = 22/135 (16%)

Query: 210  DYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHL 269
            D +   G+TPL         A+CC        Q G T +  W         G  +  E L
Sbjct: 1581 DTRGPDGVTPLM-------SAVCC-----GEVQSG-TFQGAW--------LGCPEPWEPL 1619

Query: 270  LFYGADMGAQNA-SGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGN 328
            L  GA   A    +G T LH+ A +++ + AR LL  GAN +  +   +T    A+ A  
Sbjct: 1620 LDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADA 1679

Query: 329  FELAEVIKTHKDSDV 343
             E+ +++   + + V
Sbjct: 1680 REVCQLLLRSRQTAV 1694


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
            1 [Homo sapiens]
          Length = 1298

 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 68/251 (27%), Positives = 108/251 (43%), Gaps = 6/251 (2%)

Query: 130  KVARLLDKGLDPNFH-DPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVH 188
            KV  +L  G+DPNF  +  +   PL  AA+  +  D+  +L   GA++D  + D  T + 
Sbjct: 753  KVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHV-DICHMLVQAGANIDTCSEDQRTPLM 811

Query: 189  CATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDE 248
             A    +  A+  L+  GA  D KD+ G T L+ +A  G   +   LL +    +   D+
Sbjct: 812  EAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 871

Query: 249  NGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGAN 308
             GW  +  A  + HV  ++ LL  G+D+  ++   N  LH  A       A +LL    +
Sbjct: 872  GGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCD 931

Query: 309  RDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVV---PFRETPSYAKRRRLAGPSGLA 365
                N +  +   +A     ++   V+   +DSDV       ETP           S L 
Sbjct: 932  LHAVNIHGDSPLHIAARENRYDCV-VLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQ 990

Query: 366  SPRPLQRSASD 376
              + LQ SA D
Sbjct: 991  MSKALQDSAPD 1001


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.134    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,265,879
Number of Sequences: 37866
Number of extensions: 6426967
Number of successful extensions: 80748
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 825
Number of HSP's successfully gapped in prelim test: 2098
Number of HSP's that attempted gapping in prelim test: 32943
Number of HSP's gapped (non-prelim): 33082
length of query: 1747
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1631
effective length of database: 13,855,062
effective search space: 22597606122
effective search space used: 22597606122
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.