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Search of human proteins with 29244926
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29244926 corin [Homo sapiens]
(1042 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29244926 corin [Homo sapiens] 2252 0.0
gi|223942069 enterokinase precursor [Homo sapiens] 234 4e-61
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 226 9e-59
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 226 9e-59
gi|4507157 sortilin-related receptor containing LDLR class A rep... 224 3e-58
gi|93102379 low density lipoprotein-related protein 1B precursor... 219 1e-56
gi|11415040 matriptase [Homo sapiens] 214 3e-55
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 203 8e-52
gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 197 6e-50
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 196 1e-49
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 196 1e-49
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 193 6e-49
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 187 3e-47
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 186 8e-47
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 186 1e-46
gi|58218970 protease, serine, 36 [Homo sapiens] 181 3e-45
gi|4503627 coagulation factor XI precursor [Homo sapiens] 179 1e-44
gi|4506143 neurotrypsin precursor [Homo sapiens] 179 2e-44
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 177 4e-44
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 177 4e-44
gi|157384998 low density lipoprotein receptor-related protein 4 ... 177 5e-44
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 175 2e-43
gi|4506153 prostasin preproprotein [Homo sapiens] 174 3e-43
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 174 4e-43
gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 174 4e-43
gi|13994276 marapsin [Homo sapiens] 174 5e-43
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 173 9e-43
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 171 4e-42
gi|117956391 protease, serine, 33 [Homo sapiens] 167 4e-41
gi|21614531 testisin isoform 2 [Homo sapiens] 164 4e-40
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 2252 bits (5836), Expect = 0.0
Identities = 1042/1042 (100%), Positives = 1042/1042 (100%)
Query: 1 MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVL 60
MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVL
Sbjct: 1 MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVL 60
Query: 61 LLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPA 120
LLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPA
Sbjct: 61 LLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPA 120
Query: 121 WTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHR 180
WTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHR
Sbjct: 121 WTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHR 180
Query: 181 LSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRC 240
LSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRC
Sbjct: 181 LSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRC 240
Query: 241 SQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSD 300
SQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSD
Sbjct: 241 SQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSD 300
Query: 301 EAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEW 360
EAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEW
Sbjct: 301 EAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEW 360
Query: 361 VCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS 420
VCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS
Sbjct: 361 VCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS 420
Query: 421 CQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHR 480
CQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHR
Sbjct: 421 CQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHR 480
Query: 481 TQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERC 540
TQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERC
Sbjct: 481 TQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERC 540
Query: 541 ESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCD 600
ESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCD
Sbjct: 541 ESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCD 600
Query: 601 GQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDEL 660
GQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDEL
Sbjct: 601 GQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDEL 660
Query: 661 ECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQE 720
ECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQE
Sbjct: 661 ECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQE 720
Query: 721 ILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSK 780
ILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSK
Sbjct: 721 ILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSK 780
Query: 781 ISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLT 840
ISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLT
Sbjct: 781 ISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLT 840
Query: 841 VAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSE 900
VAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSE
Sbjct: 841 VAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSE 900
Query: 901 DISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFD 960
DISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFD
Sbjct: 901 DISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFD 960
Query: 961 MKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVY 1020
MKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVY
Sbjct: 961 MKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVY 1020
Query: 1021 SNVSYFVEWIKRQIYIQTFLLN 1042
SNVSYFVEWIKRQIYIQTFLLN
Sbjct: 1021 SNVSYFVEWIKRQIYIQTFLLN 1042
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 234 bits (596), Expect = 4e-61
Identities = 137/386 (35%), Positives = 202/386 (52%), Gaps = 22/386 (5%)
Query: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHV- 713
C+ D +C N CV CDG C D SDE DCV +++ L+ R + H
Sbjct: 643 CKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTA 702
Query: 714 CADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQ 773
CA+ W +S C+ +GLG + +K I + P ++ L++ + H +L Q
Sbjct: 703 CAENWTTQISNDVCQLLGLGSGNSSKPIFSTDGGP-FVKLNTAPDG------HLILTPSQ 755
Query: 774 SCESRSKISLLCTKQDCGRRPAAR-MNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVL 832
C S I L C + CG++ AA+ + +I+GG ++ G WPW L +CG L
Sbjct: 756 QCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYG-GRLLCGASL 814
Query: 833 IAKKWVLTVAHCFEGRE-NAAVWKVVLGIN---NLDHPSVFMQTRFVKTIILHPRYSRAV 888
++ W+++ AHC GR + W +LG++ NL P R + I+++P Y+R
Sbjct: 815 VSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTV--PRLIDEIVINPHYNRRR 872
Query: 889 VDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWG---HMGNKMPFKLQEG 945
D DI+++ L ++ T Y++P+CLP Q P C I GWG + G LQE
Sbjct: 873 KDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANI-LQEA 931
Query: 946 EVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTS 1005
+V ++S E CQ IT MICAGYE G +DSC GDSGGPL+C++ RW L G+TS
Sbjct: 932 DVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTS 990
Query: 1006 WGSVCFSKVLGPGVYSNVSYFVEWIK 1031
+G C + PGVY+ VS F EWI+
Sbjct: 991 FGYKC-ALPNRPGVYARVSRFTEWIQ 1015
Score = 47.4 bits (111), Expect = 7e-05
Identities = 17/37 (45%), Positives = 23/37 (62%)
Query: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614
E C HF+C++G+CV CDG C+D SDE +C
Sbjct: 641 EPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADC 677
Score = 43.5 bits (101), Expect = 0.001
Identities = 15/29 (51%), Positives = 21/29 (72%)
Query: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENC 414
+C+NG+C+P CDG C+DGSDE +C
Sbjct: 649 QCKNGECVPLVNLCDGHLHCEDGSDEADC 677
Score = 37.4 bits (85), Expect = 0.074
Identities = 14/34 (41%), Positives = 22/34 (64%)
Query: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC 304
+ ++F C +G C+P C+G+ C+D SDEA C
Sbjct: 644 KADHFQCKNGECVPLVNLCDGHLHCEDGSDEADC 677
Score = 36.2 bits (82), Expect = 0.17
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 579 ECSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENCGC 616
EC P C C+ A CDG+ +C D SDE+N C
Sbjct: 183 ECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMC 221
Score = 35.8 bits (81), Expect = 0.22
Identities = 14/35 (40%), Positives = 20/35 (57%)
Query: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC 340
C + F C G+C+ +CDG+ C D SDE +C
Sbjct: 643 CKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADC 677
Score = 35.0 bits (79), Expect = 0.37
Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 7/46 (15%)
Query: 667 CVSRDLWCDGEADCSDSSDEWD--CVTLS-----INVNSSSFLMVH 705
C+ DL+CDGE +C D SDE + C T+ + +S SF H
Sbjct: 197 CIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATH 242
Score = 34.3 bits (77), Expect = 0.63
Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 12/61 (19%)
Query: 365 DHDCVDKSDEVNCSCH----SQGLVECRNGQ--------CIPSTFQCDGDEDCKDGSDEE 412
D + VD D++ + H +EC G CI + CDG+ +C DGSDE+
Sbjct: 158 DLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDED 217
Query: 413 N 413
N
Sbjct: 218 N 218
Score = 34.3 bits (77), Expect = 0.63
Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 6/46 (13%)
Query: 349 RCGDGRCIAMEWVCDGDHDCVDKSDEVNC------SCHSQGLVECR 388
+C +G C+ + +CDG C D SDE +C + ++ GLV R
Sbjct: 649 QCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFR 694
Score = 30.8 bits (68), Expect = 7.0
Identities = 12/28 (42%), Positives = 15/28 (53%)
Query: 624 CPSNKQCLKHTVICDGFPDCPDYMDEKN 651
C C+K + CDG +CPD DE N
Sbjct: 191 CTDALTCIKADLFCDGEVNCPDGSDEDN 218
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 226 bits (576), Expect = 9e-59
Identities = 138/391 (35%), Positives = 200/391 (51%), Gaps = 22/391 (5%)
Query: 653 SFCQDDELEC-ANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATE- 710
S C + +EC ++ C++ WCDG + C DE CV L + L V+ + +
Sbjct: 148 SKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRL---YGPNFILQVYSSQRKS 204
Query: 711 -HHVCADGWQEILSQLACKQMGLGEPSVTKL-IQEQEKEPRWLTLHSNWESLNGTTLHEL 768
H VC D W E + AC+ MG + I + ++ L++ S +++
Sbjct: 205 WHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNT---SAGNVDIYKK 261
Query: 769 LVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHIC 828
L + +C S++ +SL C CG + RI+GG ++ PG WPWQ SL + + H+C
Sbjct: 262 LYHSDACSSKAVVSLRCIA--CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ-NVHVC 318
Query: 829 GCVLIAKKWVLTVAHCFEGR-ENAAVWKVVLGINNLDHPSVFMQTRF-VKTIILHPRYSR 886
G +I +W++T AHC E N W GI L +F + V+ +I HP Y
Sbjct: 319 GGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGI--LRQSFMFYGAGYQVEKVISHPNYDS 376
Query: 887 AVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWG--HMGNKMPFKLQE 944
+ DI++++L + ++ V+PVCLPNP L+P+ C+I+GWG K L
Sbjct: 377 KTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNA 436
Query: 945 GEVRIISLEHCQS-YFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGL 1003
+V +I + C S Y IT MICAG+ G VDSC GDSGGPLV K W L G
Sbjct: 437 AKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGD 495
Query: 1004 TSWGSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034
TSWGS C +K PGVY NV F +WI RQ+
Sbjct: 496 TSWGSGC-AKAYRPGVYGNVMVFTDWIYRQM 525
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 579 ECSPSHFKC-RSGQCVLASRRCDGQADCDDDSDEENC 614
+CS S +C SG C+ S CDG + C DE C
Sbjct: 149 KCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 185
Score = 31.2 bits (69), Expect = 5.3
Identities = 13/36 (36%), Positives = 17/36 (47%)
Query: 379 CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENC 414
C + G+ +G CI + CDG C G DE C
Sbjct: 150 CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 185
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 226 bits (576), Expect = 9e-59
Identities = 138/391 (35%), Positives = 200/391 (51%), Gaps = 22/391 (5%)
Query: 653 SFCQDDELEC-ANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATE- 710
S C + +EC ++ C++ WCDG + C DE CV L + L V+ + +
Sbjct: 111 SKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRL---YGPNFILQVYSSQRKS 167
Query: 711 -HHVCADGWQEILSQLACKQMGLGEPSVTKL-IQEQEKEPRWLTLHSNWESLNGTTLHEL 768
H VC D W E + AC+ MG + I + ++ L++ S +++
Sbjct: 168 WHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNT---SAGNVDIYKK 224
Query: 769 LVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHIC 828
L + +C S++ +SL C CG + RI+GG ++ PG WPWQ SL + + H+C
Sbjct: 225 LYHSDACSSKAVVSLRCIA--CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ-NVHVC 281
Query: 829 GCVLIAKKWVLTVAHCFEGR-ENAAVWKVVLGINNLDHPSVFMQTRF-VKTIILHPRYSR 886
G +I +W++T AHC E N W GI L +F + V+ +I HP Y
Sbjct: 282 GGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGI--LRQSFMFYGAGYQVEKVISHPNYDS 339
Query: 887 AVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWG--HMGNKMPFKLQE 944
+ DI++++L + ++ V+PVCLPNP L+P+ C+I+GWG K L
Sbjct: 340 KTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNA 399
Query: 945 GEVRIISLEHCQS-YFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGL 1003
+V +I + C S Y IT MICAG+ G VDSC GDSGGPLV K W L G
Sbjct: 400 AKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK-NNIWWLIGD 458
Query: 1004 TSWGSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034
TSWGS C +K PGVY NV F +WI RQ+
Sbjct: 459 TSWGSGC-AKAYRPGVYGNVMVFTDWIYRQM 488
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 579 ECSPSHFKC-RSGQCVLASRRCDGQADCDDDSDEENC 614
+CS S +C SG C+ S CDG + C DE C
Sbjct: 112 KCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
Score = 31.2 bits (69), Expect = 5.3
Identities = 13/36 (36%), Positives = 17/36 (47%)
Query: 379 CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENC 414
C + G+ +G CI + CDG C G DE C
Sbjct: 113 CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 224 bits (572), Expect = 3e-58
Identities = 159/486 (32%), Positives = 211/486 (43%), Gaps = 102/486 (20%)
Query: 261 QENGKQLLCGRGENFLCA-SGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHTG 316
+ N +C F C SG CIP +C+ +DC D SDE+HC C + ++C +G
Sbjct: 1109 ERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSG 1168
Query: 317 KCLNYSLVCDGYDDCGDLSDEQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKS 372
C+ S VCDG +DC D SDE NC T +C +G CI W CDGD DC D S
Sbjct: 1169 MCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGS 1228
Query: 373 DE--VNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE----GDQ 426
DE VNC G C NG CIPS+ CDG DC DGSDE++C + T + Q
Sbjct: 1229 DEDPVNCEKKCNGF-RCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQ 1287
Query: 427 RCLYNPCLDSCGGSSLC----DPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQ 482
+CL++ + C G C D + + CSQ +P ++C + FG + Q
Sbjct: 1288 QCLFHSMV--CDGIIQCRDGSDEDAAFAGCSQ-DPEFHKVC-----------DEFGFQCQ 1333
Query: 483 KEASIS--W-------------ESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIP 527
IS W E++ NC +Y F +C+ H
Sbjct: 1334 NGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQF--------RCE---NGHCI 1382
Query: 528 PCRALCEHSKERCESVLGIVGLQWPEDTDCSQ---FPEENSDNQTCLMPDEYVEECSPSH 584
P R C+ + C W ++ DC P TCL P++
Sbjct: 1383 PNRWKCDREND-CG--------DWSDEKDCGDSHILPFSTPGPSTCL----------PNY 1423
Query: 585 FKCRSGQCVLASRRCDGQADCDDDSDEENC---------------GCKERDLWECPSNKQ 629
++C SG CV+ + CDG DC D SDEE C G +R +EC K
Sbjct: 1424 YRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKT 1483
Query: 630 CLKHTVICDGFPDCPDYMDEKNCS-----FCQDDELECAN-HACVSRDLWCDGEADCSDS 683
C+ + CDG DC D DE NC C E +C + AC+ CDG DCSD
Sbjct: 1484 CIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
Query: 684 SDEWDC 689
SDE C
Sbjct: 1544 SDEKAC 1549
Score = 204 bits (520), Expect = 3e-52
Identities = 156/513 (30%), Positives = 218/513 (42%), Gaps = 101/513 (19%)
Query: 239 RCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGEN------FLCASGICIPGKLQCNGY 292
RC + + + + +C PQ K C + EN + C++G CI C+
Sbjct: 1041 RCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFD 1100
Query: 293 NDCDDWSDEAHCNCS----ENLFHCH-TGKCLNYSLVCDGYDDCGDLSDEQNCDCNP--T 345
NDC D SDE +C + + F C +G C+ S CD DDCGD SDE +C+ + +
Sbjct: 1101 NDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRS 1160
Query: 346 TEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS-----CHSQGLVECRNGQCIPSTFQCD 400
E+ C G CI WVCDGD+DC D SDE NC+ C + +CRNG CIP + CD
Sbjct: 1161 DEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNF-QCRNGHCIPQRWACD 1219
Query: 401 GDEDCKDGSDEE--NCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ---- 454
GD DC+DGSDE+ NC + C RC C+ S S CD L +CS
Sbjct: 1220 GDTDCQDGSDEDPVNC---EKKCN--GFRCPNGTCIPS---SKHCD---GLRDCSDGSDE 1268
Query: 455 --CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTN--CYKYLMFFS 510
CEP LC T + ++ Q+ + S + ++Q + F
Sbjct: 1269 QHCEP----LC-------THFMDFVCKNRQQ---CLFHSMVCDGIIQCRDGSDEDAAFAG 1314
Query: 511 CTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPED--TDCSQFPEENSDNQ 568
C+ P +C+ +C++ + + L W D DC + SD
Sbjct: 1315 CS------------QDPEFHKVCDEFGFQCQNGV-CISLIWKCDGMDDCGDY----SDEA 1357
Query: 569 TCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNK 628
C P E F+C +G C+ +CD + DC D SDE++CG + P
Sbjct: 1358 NCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPS 1417
Query: 629 QCLKH------------TVICDGFPDCPDYMDEKNCSF---------------CQDDELE 661
CL + T +CDG+ DC D DE+ C C E E
Sbjct: 1418 TCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFE 1477
Query: 662 CAN-HACVSRDLWCDGEADCSDSSDEWDCVTLS 693
C C+ CDG DC D DE +C T S
Sbjct: 1478 CHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHS 1510
Score = 189 bits (479), Expect = 2e-47
Identities = 140/488 (28%), Positives = 206/488 (42%), Gaps = 91/488 (18%)
Query: 253 SRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCN---GYNDCDDWSDEAHCNCSEN 309
S +C P+ N + C +S + G L C+ GY ++ + C N
Sbjct: 1027 SLLCL-PKANNSRSCRCPED----VSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRN 1081
Query: 310 LFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCD---CNPTTEHRCGD-GRCIAMEWVCDGD 365
+ C G C+N CD +DCGD+SDE+NC C+ T+ RC + G CI + + CD +
Sbjct: 1082 QYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLE 1141
Query: 366 HDCVDKSDEVNCSCHSQGLVE--CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE 423
DC D SDE +C H E C +G CI S++ CDGD DC+D SDE NC+ I +C+
Sbjct: 1142 DDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEA 1201
Query: 424 GDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQK 483
+ +C C+ CD + + S +P+ E N G R
Sbjct: 1202 SNFQCRNGHCIPQRWA---CDGDTDCQDGSDEDPVNCEKKCN------------GFRCPN 1246
Query: 484 EASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEH-------S 536
I C L D + +H C LC H +
Sbjct: 1247 GTCIPSSKH------------------CDGLRDCSDGSDEQH---CEPLCTHFMDFVCKN 1285
Query: 537 KERC--ESVL--GIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQC 592
+++C S++ GI+ C +E++ C E+ + C F+C++G C
Sbjct: 1286 RQQCLFHSMVCDGII--------QCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVC 1337
Query: 593 VLASRRCDGQADCDDDSDEENC-------GCKERDLWECPSNKQCLKHTVICDGFPDCPD 645
+ +CDG DC D SDE NC C + C N C+ + CD DC D
Sbjct: 1338 ISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRC-ENGHCIPNRWKCDRENDCGD 1396
Query: 646 YMDEKNC-------------SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTL 692
+ DEK+C S C + C++ CV CDG DC+D SDE C L
Sbjct: 1397 WSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLL 1456
Query: 693 SINVNSSS 700
+ NV ++S
Sbjct: 1457 A-NVTAAS 1463
Score = 92.8 bits (229), Expect = 1e-18
Identities = 60/199 (30%), Positives = 86/199 (43%), Gaps = 27/199 (13%)
Query: 521 NTGEH--IP-PCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENS----------DN 567
NTG + +P PC LC S + PED S P + N
Sbjct: 1015 NTGSNACVPRPCSLLCLPKANNSRSC------RCPEDVSSSVLPSGDLMCDCPQGYQLKN 1068
Query: 568 QTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDL---WEC 624
TC+ + C + ++C +G C+ + CD DC D SDE NC DL + C
Sbjct: 1069 NTCVKEEN---TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRC 1125
Query: 625 PSNKQCLKHTVICDGFPDCPDYMDEKNCSF--CQDDELECANHACVSRDLWCDGEADCSD 682
+ C+ + CD DC D DE +C C+ DE C++ C+ CDG+ DC D
Sbjct: 1126 QESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRD 1185
Query: 683 SSDEWDCVTLSINVNSSSF 701
SDE +C + +S+F
Sbjct: 1186 WSDEANCTAIYHTCEASNF 1204
Score = 87.8 bits (216), Expect = 5e-17
Identities = 65/204 (31%), Positives = 83/204 (40%), Gaps = 31/204 (15%)
Query: 554 DTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEEN 613
+ DC +NSD C M +C + C SG C+ +S CDG DC D SDE N
Sbjct: 1141 EDDCG----DNSDESHCEM-----HQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEAN 1191
Query: 614 CGCK----ERDLWECPSNKQCLKHTVICDGFPDCPDYMDEK--NCSFCQDDELECANHAC 667
C E ++C N C+ CDG DC D DE NC + + C N C
Sbjct: 1192 CTAIYHTCEASNFQC-RNGHCIPQRWACDGDTDCQDGSDEDPVNCEK-KCNGFRCPNGTC 1249
Query: 668 VSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHH--------VCADGWQ 719
+ CDG DCSD SDE C L + F+ +R H C DG
Sbjct: 1250 IPSSKHCDGLRDCSDGSDEQHCEPLC--THFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
Query: 720 EILSQLACKQMGLGEPSVTKLIQE 743
E + C Q +P K+ E
Sbjct: 1308 EDAAFAGCSQ----DPEFHKVCDE 1327
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 219 bits (557), Expect = 1e-56
Identities = 148/463 (31%), Positives = 197/463 (42%), Gaps = 85/463 (18%)
Query: 262 ENGKQLLCGRGENFLCASGI--------CIPGKLQCNGYNDCDDWSDEAHC---NCSENL 310
+N +L C + +C SG CIP L+CNG +DC D DE C +CS +
Sbjct: 3384 DNSDELNC---DTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDY 3440
Query: 311 FHCHTGK-CLNYSLVCDGYDDCGDLSDEQNCD---CNPTTEHRCGDGRCIAMEWVCDGDH 366
F C T K C++ VCD DC D SDE NCD C P E +C + CI W CD +
Sbjct: 3441 FQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPH-EFQCKNNNCIPDHWRCDSQN 3499
Query: 367 DCVDKSDEVNCSCHSQGLVE--CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEG 424
DC D SDE NC + L + C NG C+ S F CDGD DC DGSDE NC +TSC +
Sbjct: 3500 DCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNC---ETSCSKD 3556
Query: 425 DQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRT 481
RC C+ + C G C +C P C + Y S
Sbjct: 3557 QFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPT----CSSREYICAS--------- 3603
Query: 482 QKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCE 541
A ++ N + D G C C+ + RC+
Sbjct: 3604 ---------DGCISASLKCN--------------GEYDCADGSDEMDCVTECKEDQFRCK 3640
Query: 542 SVLGIVGLQWPEDT--DCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRC 599
+ + ++W D DC + SD + C + C F C + C L C
Sbjct: 3641 NKAHCIPIRWLCDGIHDCV----DGSDEENC---ERGGNICRADEFLCNNSLCKLHFWVC 3693
Query: 600 DGQADCDDDSDE--ENCG---CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF 654
DG+ DC D+SDE + C C C +N+ CL+ +C+G +C D DE +C
Sbjct: 3694 DGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGG 3753
Query: 655 --------CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
C+ DE C+N C+ DL CD DC D SDE C
Sbjct: 3754 KLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Score = 183 bits (464), Expect = 8e-46
Identities = 129/419 (30%), Positives = 186/419 (44%), Gaps = 66/419 (15%)
Query: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDE-QNCD---CNPTTEHRCGDGRCIAMEW 360
NC+ + F C T KC+ + CD DDCGD SDE +C C P +CG G C +
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQP-GRFQCGTGLCALPAF 3374
Query: 361 VCDGDHDCVDKSDEVNCSCH--SQGLVEC-RNGQCIPSTFQCDGDEDCKDGSDEENCSVI 417
+CDG++DC D SDE+NC H G +C +N +CIP +C+G +DC D DE +C
Sbjct: 3375 ICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCP-- 3432
Query: 418 QTSCQEGDQRC-LYNPCLDS---CGGSSLCDPNNSLNNCSQ--CEPITLELCMNLPYNST 471
+ SC +C C+ C C + NC + C P + N+
Sbjct: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQC-----KNNN 3487
Query: 472 SYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKC------------- 518
P+++ +Q + S + + + NC +CT+ C
Sbjct: 3488 CIPDHWRCDSQNDCSDNSD--------EENCKPQ----TCTLKDFLCANGDCVSSRFWCD 3535
Query: 519 ---DVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPED--TDCSQFPEENSDNQTCLMP 573
D G C C + RC + + +W D DC + D ++C
Sbjct: 3536 GDFDCADGSDERNCETSCSKDQFRCSNG-QCIPAKWKCDGHEDC----KYGEDEKSC--- 3587
Query: 574 DEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC--GCKERDLWECPSNKQCL 631
+ CS + C S C+ AS +C+G+ DC D SDE +C CKE D + C + C+
Sbjct: 3588 EPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKE-DQFRCKNKAHCI 3646
Query: 632 KHTVICDGFPDCPDYMDEKNC----SFCQDDELECANHACVSRDLWCDGEADCSDSSDE 686
+CDG DC D DE+NC + C+ DE C N C CDGE DC D+SDE
Sbjct: 3647 PIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDE 3705
Score = 159 bits (402), Expect = 1e-38
Identities = 132/466 (28%), Positives = 176/466 (37%), Gaps = 87/466 (18%)
Query: 265 KQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEA--HC---NCSENLFHCHTGKCL 319
K C F C +G CI +L C+G C D SDE +C +C C+ +C+
Sbjct: 2506 KNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCI 2565
Query: 320 NYSLVCDGYDDCGDLSDEQNCDCNP--TTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
+ +CDG +DCGD SDE +C + T E RC DG CI C+ + DC D SDE NC
Sbjct: 2566 PHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC 2625
Query: 378 S-----------CHSQGLVECRNGQ-CIPSTFQCDGDEDCKDGSDEENCSVIQT------ 419
+ + G + C + C+ T+ CDG DC D SDE C V
Sbjct: 2626 NNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEEN 2685
Query: 420 --SCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYF 477
SC G RC+ N + C G C+ +C +S S+ N F
Sbjct: 2686 YFSCPSG--RCILNTWI--CDGQKDCEDGRDEFHCD---------------SSCSW-NQF 2725
Query: 478 GHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRAL-CEHS 536
QK S W C E C A+ C
Sbjct: 2726 ACSAQKCISKHWICDG---------------------EDDCGDGLDESDSICGAITCAAD 2764
Query: 537 KERCESVLGIVGLQWPED--TDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVL 594
C+ V W D DC +E S P+ C + F C + C+
Sbjct: 2765 MFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCA--PNN---TCDENAFMCHNKVCIP 2819
Query: 595 ASRRCDGQADCDDDSDEE-NCGCKE--RDLWECPSNKQCLKHTVICDGFPDCPDYMDEKN 651
CD DC D SDE CG ++ + + C + L CDG DCPD+ DE
Sbjct: 2820 KQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAP 2879
Query: 652 CS--------FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
+ C C N C+ CD + DC D SDE +C
Sbjct: 2880 LNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 158 bits (400), Expect = 2e-38
Identities = 139/482 (28%), Positives = 198/482 (41%), Gaps = 86/482 (17%)
Query: 214 SFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQL--LCGR 271
+ C GC ++ + P C+ NQ N + F+P G+ L +C
Sbjct: 796 NMCRVNNGGCSTLCLAI----PGGRVCACADNQLLDENGTTCTFNP----GEALPHICKA 847
Query: 272 GENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNC-----SENLFHCHTGKCLNYSLVCD 326
GE F C + CI + +C+G +DC D SDE NC ++ F C +C+ +CD
Sbjct: 848 GE-FRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCD 906
Query: 327 GYDDCGDLSDEQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKSDEV-NC---S 378
G +DCG DE N C T + CG+GRCI W+CD + DC D++DE+ +C +
Sbjct: 907 GANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPT 966
Query: 379 CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCG 438
C C++G+CI S + CD D+DC DGSDE C SC + RC C+
Sbjct: 967 CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCFDNQFRCSSGRCIP--- 1020
Query: 439 GSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALV 498
G CD +N + S I C +S + N + F
Sbjct: 1021 GHWACDGDNDCGDFSDEAQIN---CTKEEIHSPAGCN---------------GNEFQCHP 1062
Query: 499 QTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRA---LCEH-SKERCESVLGIVGLQW--P 552
NC L + C + D G C LC+H +K C S + W
Sbjct: 1063 DGNCVPDL--WRCD---GEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCD 1117
Query: 553 EDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCR--SGQCVLASRRCDGQADCDDDSD 610
D DC E+ SD C D ++ C P C + C+ + C+G+ DC D SD
Sbjct: 1118 GDIDC----EDQSDEDDC---DSFL--CGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSD 1168
Query: 611 EENCGCKERDLWECPSNKQCLKHTVICDG---FPDCPDYM----DEKNCSFCQDDELECA 663
E C E L +N C H + G CP+ + D K C C+
Sbjct: 1169 EGYL-CDECSL----NNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVD----YCS 1219
Query: 664 NH 665
NH
Sbjct: 1220 NH 1221
Score = 157 bits (397), Expect = 5e-38
Identities = 131/464 (28%), Positives = 187/464 (40%), Gaps = 63/464 (13%)
Query: 277 CASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHTGKCLNYSLVCDGYDDCGD 333
C + CIP C+G NDC D SDE C C+ F C G C+ S C+ DC D
Sbjct: 2559 CYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCAD 2618
Query: 334 LSDEQNCDCNPTTEH-----------RCGD-GRCIAMEWVCDGDHDCVDKSDEVNCSCHS 381
SDE+NC+ T RC C+ W+CDG +DC D SDE+ C +
Sbjct: 2619 ASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQN 2678
Query: 382 QGLVE-----CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS 436
+ E C +G+CI +T+ CDG +DC+DG DE +C +SC C C+
Sbjct: 2679 KHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCD---SSCSWNQFACSAQKCISK 2735
Query: 437 ---CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTS-YPNYF---GHRTQKEASISW 489
C G C ++ S C IT M S + P ++ G R + S
Sbjct: 2736 HWICDGEDDCGDGLDESD-SICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSD-- 2792
Query: 490 ESSLFPALVQTNCYKYLMFFSCTILVPK---CDVNT-----GEHIPPCR-ALCEHSKERC 540
E S C + + +PK CD + + P C C + C
Sbjct: 2793 ELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSC 2852
Query: 541 ESVLGIVGLQWP--EDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRR 598
++ QW D DC +E N C ++ C+ S F C++G+C+ +
Sbjct: 2853 ADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQ---SCNSSFFMCKNGRCIPSGGL 2909
Query: 599 CDGQADCDDDSDEENC---GCKERDLWECPSNKQCLKHTVICDGFP------DCPDYMDE 649
CD + DC D SDE NC C + + C + Q L + C +P D +D
Sbjct: 2910 CDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI 2969
Query: 650 KNCSFCQDDELECAN----HACVSRD---LWCDGEADCSDSSDE 686
CS +C N + C+ D + D C SDE
Sbjct: 2970 DECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDE 3013
Score = 140 bits (353), Expect = 6e-33
Identities = 112/415 (26%), Positives = 163/415 (39%), Gaps = 80/415 (19%)
Query: 338 QNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHS----QGLVECRNGQCI 393
+N CN +E CG+G CI + CDG C DKSDE C + +G C N +CI
Sbjct: 2506 KNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCI 2565
Query: 394 PSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLD---SCGGSSLCDPNNSLN 450
P CDG+ DC D SDE +C V ++C + RC C+ C + C +
Sbjct: 2566 PHGKLCDGENDCGDNSDELDCKV--STCATVEFRCADGTCIPRSARCNQNIDCADASDEK 2623
Query: 451 NCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESS---LFPALV---QTNCYK 504
NC N+T +++ + I S+ + P + +C
Sbjct: 2624 NC----------------NNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGD 2667
Query: 505 YLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPED--TDCSQFPE 562
Y C + +H CE + C S I+ W D DC E
Sbjct: 2668 YSDELKCPV--------QNKH------KCEENYFSCPSGRCILN-TWICDGQKDC----E 2708
Query: 563 ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK----E 618
+ D C CS + F C + +C+ CDG+ DC D DE + C
Sbjct: 2709 DGRDEFHC------DSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCA 2762
Query: 619 RDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC------SFCQDDELECANHACVSRDL 672
D++ C ++ C+ +CDG DCPD DE + + C ++ C N C+ +
Sbjct: 2763 ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQF 2822
Query: 673 WCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLAC 727
CD + DC D SDE S + TE CADG + +Q C
Sbjct: 2823 VCDHDDDCGDGSDE------------SPQCGYRQCGTEEFSCADGRCLLNTQWQC 2865
Score = 139 bits (349), Expect = 2e-32
Identities = 117/415 (28%), Positives = 167/415 (40%), Gaps = 57/415 (13%)
Query: 308 ENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHD 367
+N+ + G C L G C +D Q D N TT C A+ +C
Sbjct: 795 DNMCRVNNGGCSTLCLAIPGGRVCA-CADNQLLDENGTT---CTFNPGEALPHICKA--- 847
Query: 368 CVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQR 427
G C+N CI + ++CDGD+DC DGSDE++ + SC + +
Sbjct: 848 ---------------GEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFK 892
Query: 428 CLYNPCLDS---CGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYF------- 477
C N C+ C G++ C N +N C T ++ N P +
Sbjct: 893 CQNNRCIPKRWLCDGANDCGSNEDESN-QTCTARTCQVDQFSCGNGRCIPRAWLCDREDD 951
Query: 478 -GHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHS 536
G +T + AS + + L Q C S D G C C +
Sbjct: 952 CGDQTDEMASCEFPTC--EPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDN 1009
Query: 537 KERCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEYVEE---CSPSHFKCR-SG 590
+ RC S I G W D DC F +E N T E + C+ + F+C G
Sbjct: 1010 QFRCSSGRCIPG-HWACDGDNDCGDFSDEAQINCT----KEEIHSPAGCNGNEFQCHPDG 1064
Query: 591 QCVLASRRCDGQADCDDDSDEENCG-----CKERDLWECPSNKQCLKHTVICDGFPDCPD 645
CV RCDG+ DC+D SDE+ C C + + C S +C+ +CDG DC D
Sbjct: 1065 NCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 1124
Query: 646 YMDEKNCS--FCQDDELECAN--HACVSRDLWCDGEADCSDSSDE-WDCVTLSIN 695
DE +C C + CAN C+ + C+G+ DC D SDE + C S+N
Sbjct: 1125 QSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLN 1179
Score = 128 bits (322), Expect = 2e-29
Identities = 75/173 (43%), Positives = 87/173 (50%), Gaps = 24/173 (13%)
Query: 268 LCGR----GENFLC-ASGICIPGKLQCNGYNDCDDWSDE---AHC----NCSENLFHCHT 315
+CG + F C S C+P C+G DC D SDE A C C EN F CH
Sbjct: 2755 ICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHN 2814
Query: 316 GKCLNYSLVCDGYDDCGDLSDEQ-NCDCNP--TTEHRCGDGRCIA-MEWVCDGDHDCVDK 371
C+ VCD DDCGD SDE C T E C DGRC+ +W CDGD DC D
Sbjct: 2815 KVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDH 2874
Query: 372 SDE--VNCSCHS------QGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
SDE +N C S C+NG+CIPS CD +DC DGSDE NC +
Sbjct: 2875 SDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHI 2927
Score = 127 bits (319), Expect = 5e-29
Identities = 107/408 (26%), Positives = 157/408 (38%), Gaps = 79/408 (19%)
Query: 340 CDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQC 399
C P H C C ++ + C+ NC+ C+ +CIP ++C
Sbjct: 3288 CLLAPGKTHTCA---CPTNFYLAADNRTCLS-----NCTASQ---FRCKTDKCIPFWWKC 3336
Query: 400 DGDEDCKDGSDE-ENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQC 455
D +DC DGSDE ++C + CQ G +C C C G + C N+ NC
Sbjct: 3337 DTVDDCGDGSDEPDDCPEFR--CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDT- 3393
Query: 456 EPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILV 515
+C++ + T + QK P ++ N
Sbjct: 3394 -----HVCLSGQFKCT--------KNQK---------CIPVNLRCNGQD----------- 3420
Query: 516 PKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQW--PEDTDCSQFPEE-NSDNQTCLM 572
C E P + C +C++ + W ED DC+ +E N D +TC
Sbjct: 3421 -DCGDEEDERDCPENS-CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTC-- 3476
Query: 573 PDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQ 629
P F+C++ C+ RCD Q DC D+SDEENC C +D +N
Sbjct: 3477 --------GPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDF--LCANGD 3526
Query: 630 CLKHTVICDGFPDCPDYMDEKNC-SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWD 688
C+ CDG DC D DE+NC + C D+ C+N C+ CDG DC DE
Sbjct: 3527 CVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKS 3586
Query: 689 CVTLSINVNSSSFLMVHRAATE-------HHVCADGWQEILSQLACKQ 729
C S +S ++ + CADG E+ CK+
Sbjct: 3587 CEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKE 3634
Score = 124 bits (311), Expect = 5e-28
Identities = 85/237 (35%), Positives = 112/237 (47%), Gaps = 49/237 (20%)
Query: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSE-----------NLFHCH-TGKCLNYS 322
F C+SG CIPG C+G NDC D+SDEA NC++ N F CH G C+
Sbjct: 1011 FRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDL 1070
Query: 323 LVCDGYDDCGDLSDEQNCD-----CNPTTEHRC-GDGRCIAMEWVCDGDHDCVDKSDEVN 376
CDG DC D SDE+ C+ C+ T+ C GRCI WVCDGD DC D+SDE +
Sbjct: 1071 WRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDD 1130
Query: 377 CSCHSQGLVE--CRN--GQCIPSTFQCDGDEDCKDGSDE---------------ENCSV- 416
C G + C N C+ C+G +DC DGSDE +CSV
Sbjct: 1131 CDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVV 1190
Query: 417 ----IQTSCQEG------DQRC-LYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLEL 462
I SC EG ++ C + + C + S +C+ + CS E L++
Sbjct: 1191 PGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDV 1247
Score = 115 bits (288), Expect = 2e-25
Identities = 69/198 (34%), Positives = 96/198 (48%), Gaps = 33/198 (16%)
Query: 282 CIPGKLQCNGYNDCDDWSDEAHCN-----CSENLFHCHTGKCLNYSLVCDGYDDCGDLSD 336
CIP + C+G +DC D SDE +C C + F C+ C + VCDG DDCGD SD
Sbjct: 3645 CIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSD 3704
Query: 337 EQ-----NCDCNPTTEHRCGDGR-CIAMEWVCDGDHDCVDKSDEVNCS---------CHS 381
E C T HRC + R C+ E +C+G +C D SDE +C C
Sbjct: 3705 EAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKK 3764
Query: 382 QGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQT--SCQEGDQRCLYNPCLDSCGG 439
C N +CIP QCD +DC DGSDE+ C + T +C++ ++ CG
Sbjct: 3765 DEFA-CSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDN---------VNPCGD 3814
Query: 440 SSLCDPNNSLNNCSQCEP 457
+ C+ + C +C+P
Sbjct: 3815 DAYCNQIKTSVFC-RCKP 3831
Score = 104 bits (259), Expect = 5e-22
Identities = 97/361 (26%), Positives = 132/361 (36%), Gaps = 85/361 (23%)
Query: 365 DHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEG 424
D+ CV K N SC++ EC NG+CI CDG CKD S
Sbjct: 2500 DNRCVTK----NSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKS--------------- 2540
Query: 425 DQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKE 484
D++ LY C+ + C YN P+ G E
Sbjct: 2541 DEKLLY------------CENRSCRRGFKPC------------YNRRCIPH--GKLCDGE 2574
Query: 485 ASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVL 544
S V T C + +C T C RC
Sbjct: 2575 NDCGDNSDELDCKVST----------CATVEFRCADGT----------CIPRSARCN--- 2611
Query: 545 GIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQ-CVLASRRCDGQA 603
++ DC+ +E + N T + + +C S CVL + CDG
Sbjct: 2612 --------QNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSN 2663
Query: 604 DCDDDSDEENCGCK-----ERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC-SFCQD 657
DC D SDE C + E + + CPS + C+ +T ICDG DC D DE +C S C
Sbjct: 2664 DCGDYSDELKCPVQNKHKCEENYFSCPSGR-CILNTWICDGQKDCEDGRDEFHCDSSCSW 2722
Query: 658 DELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSF-LMVHRAATEHHVCAD 716
++ C+ C+S+ CDGE DC D DE D + +I + F RA H D
Sbjct: 2723 NQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCD 2782
Query: 717 G 717
G
Sbjct: 2783 G 2783
Score = 76.6 bits (187), Expect = 1e-13
Identities = 59/182 (32%), Positives = 76/182 (41%), Gaps = 50/182 (27%)
Query: 269 CGRGENFLCASGICIPG-KLQCNGYNDCDDWSDEAHCN---------CSENLFHCHTGKC 318
CG E F CA G C+ + QC+G DC D SDEA N C+ + F C G+C
Sbjct: 2845 CGT-EEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRC 2903
Query: 319 LNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378
+ +CD DDCGD SDE+NC N C++ + V DC D C
Sbjct: 2904 IPSGGLCDNKDDCGDGSDERNCHIN----------ECLSKK-VSGCSQDCQDLPVSYKCK 2952
Query: 379 C-----------HSQGLVECRNG-----QCIPS--TFQC----------DGDEDCKDGSD 410
C + EC +G QCI + T++C D CK SD
Sbjct: 2953 CWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSD 3012
Query: 411 EE 412
EE
Sbjct: 3013 EE 3014
Score = 75.9 bits (185), Expect = 2e-13
Identities = 47/137 (34%), Positives = 58/137 (42%), Gaps = 16/137 (11%)
Query: 266 QLLCGRGENFLCASG-ICIPGKLQCNGYNDCDDWSDEAHCN---------CSENLFHCHT 315
+ LC C + IC+ + CNG ++C D SDE HC C ++ F C
Sbjct: 3712 KFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSN 3771
Query: 316 GKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEV 375
KC+ L CD DDCGD SDEQ C P TE+ C D C D C V
Sbjct: 3772 KKCIPMDLQCDRLDDCGDGSDEQGCRIAP-TEYTCEDN-----VNPCGDDAYCNQIKTSV 3825
Query: 376 NCSCHSQGLVECRNGQC 392
C C +N QC
Sbjct: 3826 FCRCKPGFQRNMKNRQC 3842
Score = 69.7 bits (169), Expect = 1e-11
Identities = 47/153 (30%), Positives = 61/153 (39%), Gaps = 35/153 (22%)
Query: 570 CLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQ 629
CL+ CS CR + +L RC +N C +EC N +
Sbjct: 2479 CLLTPNGRVNCS-----CRGDRILLEDNRCV----------TKNSSCNAYSEFEC-GNGE 2522
Query: 630 CLKHTVICDGFPDCPDYMDEKNCSFCQDDELE-----CANHACVSRDLWCDGEADCSDSS 684
C+ + + CDG P C D DEK +C++ C N C+ CDGE DC D+S
Sbjct: 2523 CIDYQLTCDGIPHCKDKSDEK-LLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNS 2581
Query: 685 DEWDCVTLSINVNSSSFLMVHRAATEHHVCADG 717
DE DC V AT CADG
Sbjct: 2582 DELDC-------------KVSTCATVEFRCADG 2601
Score = 61.6 bits (148), Expect = 4e-09
Identities = 46/156 (29%), Positives = 70/156 (44%), Gaps = 32/156 (20%)
Query: 300 DEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRC--------G 351
D+ C+ E L H H C++ S +CDG DC D SDE C E +C G
Sbjct: 28 DQQLCDPGEFLCHDHV-TCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLG 86
Query: 352 DGRCIAMEWVCDGDHDCVDKSDE-VNCSCHSQGLVECRNGQC------IPSTFQC---DG 401
+C+ + +C+G DC D DE V+C + L C+ C + ++ +C DG
Sbjct: 87 TNKCVHLSQLCNGVLDCPDGYDEGVHC---QELLSNCQQLNCQYKCTMVRNSTRCYCEDG 143
Query: 402 DEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSC 437
E +DG SC++ D+ +Y C +C
Sbjct: 144 FEITEDG----------RSCKDQDECAVYGTCSQTC 169
Score = 58.2 bits (139), Expect = 4e-08
Identities = 35/96 (36%), Positives = 42/96 (43%), Gaps = 10/96 (10%)
Query: 580 CSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSN-------KQCL 631
C P F C CV S CDG DC DDSDE C E +CP N +C+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 632 KHTVICDGFPDCPDYMDEKNCSFCQDDELECANHAC 667
+ +C+G DCPD DE CQ+ C C
Sbjct: 92 HLSQLCNGVLDCPDGYDEG--VHCQELLSNCQQLNC 125
Score = 50.8 bits (120), Expect = 6e-06
Identities = 40/133 (30%), Positives = 60/133 (45%), Gaps = 16/133 (12%)
Query: 608 DSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECA-NHA 666
D D++ C E + C + C+ + +CDG PDCPD DE + ++ E++C NH
Sbjct: 26 DRDQQLCDPGE---FLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHI 82
Query: 667 -------CVSRDLWCDGEADCSDSSDEW-DCVTLSIN---VNSSSFLMVHRAATEHHVCA 715
CV C+G DC D DE C L N +N + R +T + C
Sbjct: 83 ACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCY-CE 141
Query: 716 DGWQEILSQLACK 728
DG++ +CK
Sbjct: 142 DGFEITEDGRSCK 154
Score = 35.4 bits (80), Expect = 0.28
Identities = 48/210 (22%), Positives = 71/210 (33%), Gaps = 42/210 (20%)
Query: 263 NGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYS 322
+G++ N+ G C+P L C+C+ + GK +
Sbjct: 4244 SGERCEVNHCSNYCQNGGTCVPSVL------------GRPTCSCALGFTGPNCGKTVCED 4291
Query: 323 LVCDGYDDCGDLSDEQNCDCNPT-TEHRCG----DGRCIAMEWVC---DGDHDCVDKSDE 374
+G ++ C C P T RC C+ E DG +CV +
Sbjct: 4292 FCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRY 4351
Query: 375 VNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCL 434
C V C G CI + D +C +G I +SCQ D C YN
Sbjct: 4352 EGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGK-------IASSCQLCDGYC-YN--- 4400
Query: 435 DSCGGSSLCDPNNSLNNC--------SQCE 456
GG+ DP ++ C +QCE
Sbjct: 4401 ---GGTCQLDPETNVPVCLCSTNWSGTQCE 4427
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 214 bits (546), Expect = 3e-55
Identities = 137/415 (33%), Positives = 202/415 (48%), Gaps = 39/415 (9%)
Query: 629 QCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEW- 687
+C++ + CDG+ DC D+ DE NCS + C N C CD DC D+SDE
Sbjct: 463 RCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQG 522
Query: 688 -DCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEK 746
C + ++ L + C DG E +C ++ + VT
Sbjct: 523 CSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEA----SCPKVNV----VT-------- 566
Query: 747 EPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDC--GRRPAARMNKRILG 804
T H+ + LNG L + C+ + S ++DC G R R R++G
Sbjct: 567 ----CTKHT-YRCLNGLCLSK---GNPECDGKEDCSDGSDEKDCDCGLRSFTRQ-ARVVG 617
Query: 805 GRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCF-EGR----ENAAVWKVVLG 859
G + G WPWQ SL + GHICG LI+ W+++ AHC+ + R + W LG
Sbjct: 618 GTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLG 677
Query: 860 INNLDHPSV-FMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQ 918
+++ S +Q R +K II HP ++ DYDI+++EL + + VRP+CLP+
Sbjct: 678 LHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASH 737
Query: 919 WLEPDTYCYITGWGH--MGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESG 976
++TGWGH G LQ+GE+R+I+ C++ + IT RM+C G+ SG
Sbjct: 738 VFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQ-ITPRMMCVGFLSG 796
Query: 977 TVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIK 1031
VDSC GDSGGPL + GR G+ SWG C + PGVY+ + F +WIK
Sbjct: 797 GVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQR-NKPGVYTRLPLFRDWIK 850
Score = 128 bits (321), Expect = 3e-29
Identities = 63/148 (42%), Positives = 86/148 (58%), Gaps = 10/148 (6%)
Query: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNC-SENLFHCHTGKCLNYSLVCDGYDDCGD 333
F C +G CI +L+C+G+ DC D SDE +C+C + + F C C VCD +DCGD
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGD 516
Query: 334 LSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC------SCHSQGLVEC 387
SDEQ C C P RC +G+C++ C+G DC D SDE +C +C ++ C
Sbjct: 517 NSDEQGCSC-PAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC-TKHTYRC 574
Query: 388 RNGQCI-PSTFQCDGDEDCKDGSDEENC 414
NG C+ +CDG EDC DGSDE++C
Sbjct: 575 LNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 125 bits (315), Expect = 2e-28
Identities = 59/147 (40%), Positives = 79/147 (53%), Gaps = 6/147 (4%)
Query: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVD 370
F C TG+C+ L CDG+ DC D SDE NC C+ + C + C + WVCD +DC D
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGD 516
Query: 371 KSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQ-TSCQEGDQRCL 429
SDE CSC +Q C NG+C+ + QC+G +DC DGSDE +C + +C + RCL
Sbjct: 517 NSDEQGCSCPAQ-TFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCL 575
Query: 430 YNPCLD----SCGGSSLCDPNNSLNNC 452
CL C G C + +C
Sbjct: 576 NGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 102 bits (253), Expect = 2e-21
Identities = 47/113 (41%), Positives = 61/113 (53%), Gaps = 2/113 (1%)
Query: 582 PSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFP 641
P F CR+G+C+ RCDG ADC D SDE NC C + C NK C +CD
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTC-KNKFCKPLFWVCDSVN 512
Query: 642 DCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSI 694
DC D DE+ CS C C+N C+S+ C+G+ DC D SDE C +++
Sbjct: 513 DCGDNSDEQGCS-CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNV 564
Score = 100 bits (250), Expect = 5e-21
Identities = 51/118 (43%), Positives = 62/118 (52%), Gaps = 8/118 (6%)
Query: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGY 328
C G F C + C P C+ NDC D SDE C+C F C GKCL+ S C+G
Sbjct: 488 CDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGK 547
Query: 329 DDCGDLSDEQNC------DCNPTTEHRCGDGRCIAM-EWVCDGDHDCVDKSDEVNCSC 379
DDCGD SDE +C C T +RC +G C++ CDG DC D SDE +C C
Sbjct: 548 DDCGDGSDEASCPKVNVVTCTKHT-YRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 61.2 bits (147), Expect = 5e-09
Identities = 40/140 (28%), Positives = 57/140 (40%), Gaps = 28/140 (20%)
Query: 518 CDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYV 577
C + G C+ C+SV DC +NSD Q C
Sbjct: 486 CSCDAGHQFTCKNKFCKPLFWVCDSV-----------NDCG----DNSDEQGC------- 523
Query: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG-----CKERDLWECPSNKQCLK 632
C F+C +G+C+ S++C+G+ DC D SDE +C + + C + K
Sbjct: 524 -SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSK 582
Query: 633 HTVICDGFPDCPDYMDEKNC 652
CDG DC D DEK+C
Sbjct: 583 GNPECDGKEDCSDGSDEKDC 602
Score = 47.8 bits (112), Expect = 6e-05
Identities = 28/75 (37%), Positives = 32/75 (42%), Gaps = 9/75 (12%)
Query: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYN----PCLDSCG 438
G CR G+CI +CDG DC D SDE NC SC G Q N P C
Sbjct: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCD 509
Query: 439 GSSLCDPNNSLNNCS 453
+ C N+ CS
Sbjct: 510 SVNDCGDNSDEQGCS 524
Score = 44.7 bits (104), Expect = 5e-04
Identities = 20/55 (36%), Positives = 30/55 (54%), Gaps = 3/55 (5%)
Query: 563 ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASR-RCDGQADCDDDSDEENCGC 616
+ SD +C P V C+ ++C +G C+ CDG+ DC D SDE++C C
Sbjct: 552 DGSDEASC--PKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 40.8 bits (94), Expect = 0.007
Identities = 37/137 (27%), Positives = 50/137 (36%), Gaps = 21/137 (15%)
Query: 192 CTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSN 251
CT E D H FC+ C+SV + S C QT +
Sbjct: 477 CTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPA---QTFRCS 533
Query: 252 VSRICFSPQQENGKQLLCGRGEN----------------FLCASGICIP-GKLQCNGYND 294
+ QQ NGK CG G + + C +G+C+ G +C+G D
Sbjct: 534 NGKCLSKSQQCNGKDD-CGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKED 592
Query: 295 CDDWSDEAHCNCSENLF 311
C D SDE C+C F
Sbjct: 593 CSDGSDEKDCDCGLRSF 609
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 203 bits (516), Expect = 8e-52
Identities = 150/476 (31%), Positives = 212/476 (44%), Gaps = 86/476 (18%)
Query: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHC-HTGKCLNYSLVCD 326
R F C++GIC C+G NDC D SDEA+C+ C + F C +T +C+ C+
Sbjct: 3375 RPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCN 3434
Query: 327 GYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDE-VNCSCHSQ 382
G D+CGD DE++C C P RCI WVCD D+DCVD SDE NC+ +
Sbjct: 3435 GQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTC 3494
Query: 383 GLVECR---NGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGG 439
G+ E R +G+CIP+ ++CDG++DC DGSDE + +C+ RC N C+ G
Sbjct: 3495 GVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVP---G 3551
Query: 440 SSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQ 499
CD +N + S E T C ++ + G W
Sbjct: 3552 RWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGR---------W---------- 3592
Query: 500 TNCYKYLMFFSCTILVPKCDVN----TGEHIPPCRALCEHSKERCESVLGIVGLQW--PE 553
KCD + G C C+ + +C+S + L+W
Sbjct: 3593 -----------------KCDGDHDCADGSDEKDCTPRCDMDQFQCKSG-HCIPLRWRCDA 3634
Query: 554 DTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDE-- 611
D DC + SD + C V C F+C + C + +CDG+ DC D+SDE
Sbjct: 3635 DADCM----DGSDEEAC---GTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENP 3687
Query: 612 ENCG---CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC-------SFCQD-DEL 660
E C C + C +++ CL CDG +C D DE++C + C+D E
Sbjct: 3688 EECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEF 3747
Query: 661 ECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCAD 716
C N C+S L C+ DC D SDE DC SI+ +S AT +C D
Sbjct: 3748 LCRNQRCLSSSLRCNMFDDCGDGSDEEDC---SIDPKLTS------CATNASICGD 3794
Score = 172 bits (437), Expect = 1e-42
Identities = 142/515 (27%), Positives = 201/515 (39%), Gaps = 126/515 (24%)
Query: 216 CEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENF 275
C GC S+ + P +C+ +Q ++ +P Q C GE F
Sbjct: 807 CRVNNGGCSSLC----LATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQ--CQPGE-F 859
Query: 276 LCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENL-----FHCHTGKCLNYSLVCDGYDD 330
CA+ CI + +C+G NDC D SDEA C ++ F C +C+ +CDG +D
Sbjct: 860 ACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDND 919
Query: 331 CGDLSDEQNCDCN----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDE-VNC---SCHSQ 382
CG+ DE N C+ P + C GRCI + W CD D DC D+SDE +C +C
Sbjct: 920 CGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPL 979
Query: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSL 442
C NG+CI ++CD D DC D SDE CS SC +C C+
Sbjct: 980 TQFTCNNGRCININWRCDNDNDCGDNSDEAGCS---HSCSSTQFKCNSGRCIPE---HWT 1033
Query: 443 CDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502
CD +N + Y+ ++ N T+
Sbjct: 1034 CDGDNDCGD----------------YSDETHANCTNQATR-------------------- 1057
Query: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPE 562
P +T E LC + RC+ DTDC
Sbjct: 1058 -------------PPGGCHTDEFQCRLDGLCIPLRWRCDG-----------DTDCM---- 1089
Query: 563 ENSDNQTCLMPDEYVEECSPS-HFKCR-SGQCVLASRRCDGQADCDDDSDEENC---GCK 617
++SD ++C + C PS F C+ S +C+ + CDG DC+D+SDEENC C+
Sbjct: 1090 DSSDEKSC---EGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACR 1146
Query: 618 ERDLWECPSNKQ-CLKHTVICDGFPDCPDYMDE---------------KNCSFCQDDELE 661
C +N CL +CDG DC D DE NCS + +
Sbjct: 1147 PPS-HPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIV 1205
Query: 662 CA----------NHACVSRDLWCDGEADCSDSSDE 686
C+ NH C + +C CS D+
Sbjct: 1206 CSCPLGMELGPDNHTCQIQS-YCAKHLKCSQKCDQ 1239
Score = 172 bits (437), Expect = 1e-42
Identities = 136/441 (30%), Positives = 184/441 (41%), Gaps = 80/441 (18%)
Query: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGD 333
N C G + L C N DE F C G+C+N+SL CDG C D
Sbjct: 2502 NCSCRGGRILQDDLTCRAVNSSCRAQDE---------FECANGECINFSLTCDGVPHCKD 2552
Query: 334 LSDEQNCDCN----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVE--C 387
SDE+ CN T +C +GRC++ C+G DC D SDE+ C+ + G+ E C
Sbjct: 2553 KSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRC 2612
Query: 388 RNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSC--QEGDQRCLYNPC--LDSCGGSS-L 442
R+G CI ++ +C+ DC+D SDE NCS S + G + L+ PC C S +
Sbjct: 2613 RDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWV 2672
Query: 443 CDPNNSLNNCS---QCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQ 499
CD N + S C + C NYF + + +SW
Sbjct: 2673 CDGANDCGDYSDERDCPGVKRPRCP---------LNYFACPSGRCIPMSW---------- 2713
Query: 500 TNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPED--TDC 557
C K + D GE C C ++ C++ + QW D DC
Sbjct: 2714 -TCDK------------EDDCEHGEDETHCNKFCSEAQFECQN-HRCISKQWLCDGSDDC 2759
Query: 558 SQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQ-CVLASRRCDGQADCDDDSDEE---- 612
+E + + + C PS F C CV CDG DC D +DE
Sbjct: 2760 GDGSDEAAHCEG--------KTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAG 2811
Query: 613 ---NCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEK-NCSF--CQDDELECANHA 666
N C +R+ + C N+QC+ +CD DC D DE C + C E CAN
Sbjct: 2812 CLYNSTCDDRE-FMC-QNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGR 2869
Query: 667 CVSRDLW-CDGEADCSDSSDE 686
C+S W CDGE DC D SDE
Sbjct: 2870 CLSSRQWECDGENDCHDQSDE 2890
Score = 163 bits (412), Expect = 9e-40
Identities = 128/444 (28%), Positives = 179/444 (40%), Gaps = 51/444 (11%)
Query: 277 CASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHTGKCLNYSLVCDGYDDCGD 333
C++G C+ L CNG +DC D SDE CN C F C G C+ S C+ + DC D
Sbjct: 2573 CSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCED 2632
Query: 334 LSDEQNCDCNPTTEH-RCG-----------DGRCIAMEWVCDGDHDCVDKSDEVNCSCHS 381
SDE NC + + R G C A WVCDG +DC D SDE +C
Sbjct: 2633 ASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVK 2692
Query: 382 Q-----GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS 436
+ C +G+CIP ++ CD ++DC+ G DE +C+ C E C + C+
Sbjct: 2693 RPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKF---CSEAQFECQNHRCISK 2749
Query: 437 ---CGGSSLCDPNNSLNNCSQCEPITL-ELCMNLPYNSTSYPNYFGHRTQKEASISWESS 492
C GS C + + + CE T + P P + K+ + + S
Sbjct: 2750 QWLCDGSDDCGDGS--DEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADES 2807
Query: 493 LFPA-LVQTNCYKYLMFFSCTILVPK---CD-----VNTGEHIPPCR-ALCEHSKERCES 542
+ L + C +PK CD + + P C C S+ RC +
Sbjct: 2808 IAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCAN 2867
Query: 543 VLGIVGLQWPED--TDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCD 600
+ QW D DC +E N C + + S F C SG+CV + C+
Sbjct: 2868 GRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCN--ASSQFLCSSGRCVAEALLCN 2925
Query: 601 GQADCDDDSDEENC---GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQD 657
GQ DC D SDE C C R L C + + LK C P D + C+
Sbjct: 2926 GQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCA---- 2981
Query: 658 DELECA-NHACVSRDLWCDGEADC 680
D EC+ C R + G C
Sbjct: 2982 DVDECSTTFPCSQRCINTHGSYKC 3005
Score = 156 bits (395), Expect = 8e-38
Identities = 135/500 (27%), Positives = 196/500 (39%), Gaps = 137/500 (27%)
Query: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDE--AHCN---CSENLFHCHTGKCLNYSL 323
C + F CA+G CI L C+G C D SDE ++CN C + C G+C++ L
Sbjct: 2524 CRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNML 2583
Query: 324 VCDGYDDCGDLSDEQNCDCNPTT----EHRCGDGRCI----------------------- 356
C+G DDCGD SDE CN T E RC DG CI
Sbjct: 2584 WCNGADDCGDGSDE--IPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSA 2641
Query: 357 --------------------------AMEWVCDGDHDCVDKSDEVNCSCHSQ-----GLV 385
A WVCDG +DC D SDE +C +
Sbjct: 2642 TDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYF 2701
Query: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSL 442
C +G+CIP ++ CD ++DC+ G DE +C+ C E C + C+ C GS
Sbjct: 2702 ACPSGRCIPMSWTCDKEDDCEHGEDETHCNKF---CSEAQFECQNHRCISKQWLCDGSDD 2758
Query: 443 CDPNNSLNNCSQCEPITL-ELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFP-ALVQT 500
C + + + CE T + P P + K+ + + S+ L +
Sbjct: 2759 C--GDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNS 2816
Query: 501 NCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQF 560
C +PK +C+H D DC+
Sbjct: 2817 TCDDREFMCQNRQCIPK------------HFVCDH------------------DRDCADG 2846
Query: 561 PEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRR--CDGQADCDDDSDE--ENCGC 616
+E+ + C P C PS F+C +G+C L+SR+ CDG+ DC D SDE +N C
Sbjct: 2847 SDESPE---CEYP-----TCGPSEFRCANGRC-LSSRQWECDGENDCHDQSDEAPKNPHC 2897
Query: 617 KERDLWECPSNKQ-------CLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVS 669
++ +C ++ Q C+ ++C+G DC D DE+ C + C+S
Sbjct: 2898 TSQE-HKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHI----------NECLS 2946
Query: 670 RDLWCDGEADCSDSSDEWDC 689
R L DC D + C
Sbjct: 2947 RKL-SGCSQDCEDLKIGFKC 2965
Score = 156 bits (394), Expect = 1e-37
Identities = 127/436 (29%), Positives = 184/436 (42%), Gaps = 66/436 (15%)
Query: 282 CIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCH-TGKCLNYSLVCDGYDDCGDLSDE 337
CIPG +CNG ++C D DE C C+ N F C T +C+ VCD +DC D SDE
Sbjct: 3426 CIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3485
Query: 338 QNCDCNPTT----EHRCGD-GRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGL----VECR 388
+C T E RC D GRCI W CDG+ DC D SDE C + C+
Sbjct: 3486 P-ANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCK 3544
Query: 389 NGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDP 445
N +C+P +QCD D DC D SDEE+C+ C E + C C+ C G C
Sbjct: 3545 NNRCVPGRWQCDYDNDCGDNSDEESCT--PRPCSESEFSCANGRCIAGRWKCDGDHDCAD 3602
Query: 446 NNSLNNCS-QCEPITLEL----CMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQT 500
+ +C+ +C+ + C+ L + + + ++ + L +
Sbjct: 3603 GSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTC---PLDEF 3659
Query: 501 NCYKYLMFFSCTILVPKCDV------NTGEHIPPC-RALCEHSKE-RCES--VLGIVGLQ 550
C L C L KCD N+ E+ C R +C ++ RC++ V +G Q
Sbjct: 3660 QCNNTL----CKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQ 3715
Query: 551 WPEDTDCSQFPEENSDNQTCLMPDEYVEECSPS-HFKCRSGQCVLASRRCDGQADCDDDS 609
+C + +D + C P + C F CR+ +C+ +S RC+ DC D S
Sbjct: 3716 CDGTDNCG----DGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGS 3771
Query: 610 DEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVS 669
DEE+C P C + IC DE C + + A AC S
Sbjct: 3772 DEEDCSID-------PKLTSCATNASICG---------DEARCVRTE----KAAYCACRS 3811
Query: 670 RDLWCDGEADCSDSSD 685
G+ C D ++
Sbjct: 3812 GFHTVPGQPGCQDINE 3827
Score = 155 bits (393), Expect = 1e-37
Identities = 86/223 (38%), Positives = 112/223 (50%), Gaps = 15/223 (6%)
Query: 258 SPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENL-----FH 312
S + N Q+ CG E SG CIP + +C+G +DC D SDE C E F
Sbjct: 3483 SDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFR 3542
Query: 313 CHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHR--CGDGRCIAMEWVCDGDHDCVD 370
C +C+ CD +DCGD SDE++C P +E C +GRCIA W CDGDHDC D
Sbjct: 3543 CKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCAD 3602
Query: 371 KSDEVNCSCH-SQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRC- 428
SDE +C+ +C++G CIP ++CD D DC DGSDEE C +C + +C
Sbjct: 3603 GSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCN 3662
Query: 429 --LYNPCLDSCGGSSLCDPNNSLN--NCSQ--CEPITLELCMN 465
L P C G C N+ N C++ C P C N
Sbjct: 3663 NTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKN 3705
Score = 154 bits (389), Expect = 4e-37
Identities = 131/427 (30%), Positives = 182/427 (42%), Gaps = 56/427 (13%)
Query: 299 SDEAHC--NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDE-QNC---DCNPTTEHRCGD 352
SD C NC+ + F C KC+ + CD DDCGD SDE +C C P + +C
Sbjct: 3325 SDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRP-GQFQCST 3383
Query: 353 GRCIAMEWVCDGDHDCVDKSDEVNCSCH--SQGLVECRN-GQCIPSTFQCDGDEDCKDGS 409
G C ++CDGD+DC D SDE NC H +C N +CIP F+C+G ++C DG
Sbjct: 3384 GICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGE 3443
Query: 410 DEENCSVIQTSCQEGDQRCLYN----PCLDSCGGSSLC-DPNNSLNNCSQCEPITLEL-C 463
DE +C + +C +C P + C + C D ++ NC+Q E C
Sbjct: 3444 DERDCP--EVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRC 3501
Query: 464 MNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVP------- 516
+ + P + + + + +T C Y VP
Sbjct: 3502 KD---SGRCIPARWKCDGEDDCGDGSDEPKEECDERT-CEPYQFRCKNNRCVPGRWQCDY 3557
Query: 517 --KCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLM 572
C N+ E R C S+ C + I G +W D DC+ + SD + C
Sbjct: 3558 DNDCGDNSDEESCTPRP-CSESEFSCANGRCIAG-RWKCDGDHDCA----DGSDEKDC-- 3609
Query: 573 PDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKER----DLWECPSNK 628
C F+C+SG C+ RCD ADC D SDEE CG R D ++C +N
Sbjct: 3610 ----TPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQC-NNT 3664
Query: 629 QCLKHTVICDGFPDCPDYMDE--KNCS--FCQDDE-LECAN-HACVSRDLWCDGEADCSD 682
C CDG DC D DE + C+ C + C N C+ CDG +C D
Sbjct: 3665 LCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGD 3724
Query: 683 SSDEWDC 689
+DE DC
Sbjct: 3725 GTDEEDC 3731
Score = 151 bits (382), Expect = 3e-36
Identities = 123/454 (27%), Positives = 172/454 (37%), Gaps = 122/454 (26%)
Query: 309 NLFHCHTGKCLNYSLVCDGYDDCGDLSDEQ------NCDCNPTT---------EHRCGDG 353
N + G C + L G C D+ C NP+ E C +
Sbjct: 805 NKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANS 864
Query: 354 RCIAMEWVCDGDHDCVDKSDEVNCSCHSQGL----VECRNGQCIPSTFQCDGDEDCKDGS 409
RCI W CDGD+DC+D SDE CH +C N +CIP+ + CDGD DC +
Sbjct: 865 RCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSE 924
Query: 410 DEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYN 469
DE N + +C C C+ S CD ++
Sbjct: 925 DESNATCSARTCPPNQFSCASGRCIPI---SWTCDLDDDC-------------------- 961
Query: 470 STSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPC 529
G R+ + AS ++ + FP L F+C N G
Sbjct: 962 --------GDRSDESASCAYPTC-FP----------LTQFTC---------NNGR----- 988
Query: 530 RALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRS 589
C + RC++ D DC +NSD C CS + FKC S
Sbjct: 989 ---CININWRCDN-----------DNDCG----DNSDEAGCS------HSCSSTQFKCNS 1024
Query: 590 GQCVLASRRCDGQADCDDDSDEENCGCKER----------DLWECPSNKQCLKHTVICDG 639
G+C+ CDG DC D SDE + C + D ++C + C+ CDG
Sbjct: 1025 GRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDG 1084
Query: 640 FPDCPDYMDEKNCS----FCQDD-ELECANHA-CVSRDLWCDGEADCSDSSDEWDCVTLS 693
DC D DEK+C C + C + A C+S+ CDG+ DC D+SDE +C +L+
Sbjct: 1085 DTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLA 1144
Query: 694 INV-------NSSSFLMVHRAATEHHVCADGWQE 720
N+S L + + C DG E
Sbjct: 1145 CRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDE 1178
Score = 144 bits (362), Expect = 6e-34
Identities = 114/382 (29%), Positives = 157/382 (41%), Gaps = 82/382 (21%)
Query: 335 SDEQNCDCNPT-TEHRCGDGRCIAMEWVCDGDHDCVDKSDEV-NC---SCHSQGLVECRN 389
SD + C N T ++ C + +CI W CD + DC D SDE +C C G +C
Sbjct: 3325 SDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRP-GQFQCST 3383
Query: 390 GQCIPSTFQCDGDEDCKDGSDEENCSV-----IQTSCQEGDQRCLYNPCLDSCGGSSLCD 444
G C F CDGD DC+D SDE NC + Q C + RC+ P + C G C
Sbjct: 3384 GICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTN-RCI--PGIFRCNGQDNCG 3440
Query: 445 PNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYK 504
+C + T PN F K
Sbjct: 3441 DGEDERDCPEV---------------TCAPNQFQCSITKR-------------------- 3465
Query: 505 YLMFFSCTILVPKCD-----VNTGEHIPPCRAL-CEHSKERCESVLGIVGLQWPED--TD 556
C V CD V+ + C + C + RC+ + +W D D
Sbjct: 3466 ------CIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDD 3519
Query: 557 C---SQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEEN 613
C S P+E D +TC P F+C++ +CV +CD DC D+SDEE+
Sbjct: 3520 CGDGSDEPKEECDERTC----------EPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEES 3569
Query: 614 C---GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCS-FCQDDELECANHACVS 669
C C E + + C +N +C+ CDG DC D DEK+C+ C D+ +C + C+
Sbjct: 3570 CTPRPCSESE-FSC-ANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIP 3627
Query: 670 RDLWCDGEADCSDSSDEWDCVT 691
CD +ADC D SDE C T
Sbjct: 3628 LRWRCDADADCMDGSDEEACGT 3649
Score = 114 bits (284), Expect = 6e-25
Identities = 71/240 (29%), Positives = 113/240 (47%), Gaps = 39/240 (16%)
Query: 198 ECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICF 257
+C D++H C FC A+ C++ ++ W C + + S+ + C
Sbjct: 2720 DCEHGEDETH----CNKFCSEAQFECQNHR-CISKQW----LCDGSDDCGDGSDEAAHC- 2769
Query: 258 SPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEA-------HCNCSENL 310
GK CG + +C+P + C+G DC D +DE+ + C +
Sbjct: 2770 -----EGKT--CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDRE 2822
Query: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQ-NCD---CNPTTEHRCGDGRCI-AMEWVCDGD 365
F C +C+ VCD DC D SDE C+ C P +E RC +GRC+ + +W CDG+
Sbjct: 2823 FMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGP-SEFRCANGRCLSSRQWECDGE 2881
Query: 366 HDCVDKSDEV----NCS-----CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
+DC D+SDE +C+ C++ C +G+C+ C+G +DC D SDE C +
Sbjct: 2882 NDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHI 2941
Score = 94.0 bits (232), Expect = 7e-19
Identities = 71/272 (26%), Positives = 98/272 (36%), Gaps = 72/272 (26%)
Query: 515 VPKCDVNTGEHIPPCRAL-CEHSKERCESVLGIVGLQWPEDTD-CSQFPEENSDNQTCLM 572
VP C + E C + C+ + +C + + + W D C +E N+T
Sbjct: 2547 VPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTA-- 2604
Query: 573 PDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC-----------GCKERDL 621
C F+CR G C+ S RC+ DC+D SDE NC G K
Sbjct: 2605 -------CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLF 2657
Query: 622 WECPSNKQCLKHTVICDGFPDCPDYMDEKNC----------------------------- 652
C C + +CDG DC DY DE++C
Sbjct: 2658 QPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDK 2717
Query: 653 --------------SFCQDDELECANHACVSRDLWCDGEADCSDSSDE-WDCVTLSINVN 697
FC + + EC NH C+S+ CDG DC D SDE C + +
Sbjct: 2718 EDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPS 2777
Query: 698 SSSFLMVHRAATEHHV------CADGWQEILS 723
S S H E + CADG E ++
Sbjct: 2778 SFSCPGTHVCVPERWLCDGDKDCADGADESIA 2809
Score = 82.4 bits (202), Expect = 2e-15
Identities = 67/207 (32%), Positives = 94/207 (45%), Gaps = 34/207 (16%)
Query: 273 ENFLCA-SGICIPGKLQCNGYNDCDDWSDEAHCN-----CSENL-FHCH-TGKCLNYSLV 324
+ F C G+CIP + +C+G DC D SDE C C ++ F C + +C++ + V
Sbjct: 1065 DEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWV 1124
Query: 325 CDGYDDCGDLSDEQNCD---CNPTTEHRCGDGR--CIAMEWVCDGDHDCVDKSDE----V 375
CDG +DC D SDE+NC+ C P + H C + C+ + +CDG+ DC D SDE
Sbjct: 1125 CDGDNDCEDNSDEENCESLACRPPS-HPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCD 1183
Query: 376 NCSCHSQGLVECRNGQCIPST-FQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCL 434
CS ++ G N P C + G D C IQ+ C + +C
Sbjct: 1184 QCSLNNGGC--SHNCSVAPGEGIVCSCPLGMELGPDNHTCQ-IQSYCAK-HLKC------ 1233
Query: 435 DSCGGSSLCDPNNSLNNCSQCEPITLE 461
S CD N CS E LE
Sbjct: 1234 -----SQKCDQNKFSVKCSCYEGWVLE 1255
Score = 80.5 bits (197), Expect = 8e-15
Identities = 57/182 (31%), Positives = 78/182 (42%), Gaps = 24/182 (13%)
Query: 565 SDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDL--- 621
SD +TC V C+ S F C++ +C+ +CD + DC D SDE C E
Sbjct: 3325 SDGRTC------VSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPP-DCPEFKCRPG 3377
Query: 622 -WECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF--CQDDELECAN-HACVSRDLWCDGE 677
++C S C ICDG DC D DE NC C + +C N + C+ C+G+
Sbjct: 3378 QFQC-STGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQ 3436
Query: 678 ADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHV------CADGWQEILSQLACKQMG 731
+C D DE DC ++ N + R V C DG E + C QM
Sbjct: 3437 DNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPAN---CTQMT 3493
Query: 732 LG 733
G
Sbjct: 3494 CG 3495
Score = 79.7 bits (195), Expect = 1e-14
Identities = 52/177 (29%), Positives = 82/177 (46%), Gaps = 17/177 (9%)
Query: 529 CRALCEHSKERCESVLGIVGLQWPEDT--DCSQFPEENSDNQTCLMPDEYVEECSPSHFK 586
C + C S+ C++ + W DT DC +E PD +C P F+
Sbjct: 3330 CVSNCTASQFVCKNDK-CIPFWWKCDTEDDCGDHSDEP--------PDCPEFKCRPGQFQ 3380
Query: 587 CRSGQCVLASRRCDGQADCDDDSDEENCGCKE--RDLWECPSNKQCLKHTVICDGFPDCP 644
C +G C + CDG DC D+SDE NC ++C + +C+ C+G +C
Sbjct: 3381 CSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCG 3440
Query: 645 DYMDEKNCS--FCQDDELECA-NHACVSRDLWCDGEADCSDSSDE-WDCVTLSINVN 697
D DE++C C ++ +C+ C+ R CD + DC D SDE +C ++ V+
Sbjct: 3441 DGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVD 3497
Score = 77.0 bits (188), Expect = 8e-14
Identities = 51/156 (32%), Positives = 71/156 (45%), Gaps = 31/156 (19%)
Query: 235 PDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKL-QCNGYN 293
P C R+ + S+ S C P CG E F CA+G C+ + +C+G N
Sbjct: 2832 PKHFVCDHDRDCADGSDESPECEYPT--------CGPSE-FRCANGRCLSSRQWECDGEN 2882
Query: 294 DCDDWSDEA----HCNCSENL------FHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCN 343
DC D SDEA HC E+ F C +G+C+ +L+C+G DDCGD SDE+ C N
Sbjct: 2883 DCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHIN 2942
Query: 344 PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSC 379
C++ + + DC D C C
Sbjct: 2943 ----------ECLSRK-LSGCSQDCEDLKIGFKCRC 2967
Score = 74.7 bits (182), Expect = 4e-13
Identities = 42/124 (33%), Positives = 58/124 (46%), Gaps = 20/124 (16%)
Query: 570 CLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQ 629
CL+ + CS CR G+ + C N C+ +D +EC +N +
Sbjct: 2493 CLLTHQGHVNCS-----CRGGRILQDDLTCRAV----------NSSCRAQDEFEC-ANGE 2536
Query: 630 CLKHTVICDGFPDCPDYMDEK----NCSFCQDDELECANHACVSRDLWCDGEADCSDSSD 685
C+ ++ CDG P C D DEK N C+ +C+N CVS LWC+G DC D SD
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSD 2596
Query: 686 EWDC 689
E C
Sbjct: 2597 EIPC 2600
Score = 58.5 bits (140), Expect = 3e-08
Identities = 32/90 (35%), Positives = 45/90 (50%), Gaps = 11/90 (12%)
Query: 342 CNPTTEHRCGDG-RCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQ--------C 392
C+P + C D CI+ W CDG+ DC D SDE C C+ + C
Sbjct: 27 CSPK-QFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
Query: 393 IPSTFQCDGDEDCKDGSDE-ENCSVIQTSC 421
+P + C+G +DC DGSDE +C +Q +C
Sbjct: 86 VPMSRLCNGVQDCMDGSDEGPHCRELQGNC 115
Score = 58.2 bits (139), Expect = 4e-08
Identities = 46/146 (31%), Positives = 58/146 (39%), Gaps = 23/146 (15%)
Query: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLV-CDG 327
C FLC+SG C+ L CNG +DC D SDE CH +CL+ L C
Sbjct: 2904 CNASSQFLCSSGRCVAEALLCNGQDDCGDSSDER---------GCHINECLSRKLSGCS- 2953
Query: 328 YDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVEC 387
DC DL C C P + DGR A C C + ++ G +C
Sbjct: 2954 -QDCEDLKIGFKCRCRPGFRLK-DDGRTCADVDECSTTFPCSQR------CINTHGSYKC 3005
Query: 388 RNGQCIPSTFQCDGD-EDCKDGSDEE 412
C+ GD CK +DEE
Sbjct: 3006 ---LCVEGYAPRGGDPHSCKAVTDEE 3028
Score = 55.8 bits (133), Expect = 2e-07
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 10/96 (10%)
Query: 580 CSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQ-------CL 631
CSP F CR C+ RCDG+ DC D SDE C + C N+ C+
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 632 KHTVICDGFPDCPDYMDEKNCSFCQDDELECANHAC 667
+ +C+G DC D DE C++ + C+ C
Sbjct: 87 PMSRLCNGVQDCMDGSDEG--PHCRELQGNCSRLGC 120
Score = 43.9 bits (102), Expect = 8e-04
Identities = 22/74 (29%), Positives = 31/74 (41%), Gaps = 5/74 (6%)
Query: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGY 328
C + FLC + C+ L+CN ++DC D SDE C+ L C T + +C
Sbjct: 3741 CKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATN-----ASICGDE 3795
Query: 329 DDCGDLSDEQNCDC 342
C C C
Sbjct: 3796 ARCVRTEKAAYCAC 3809
Score = 41.6 bits (96), Expect = 0.004
Identities = 43/183 (23%), Positives = 66/183 (36%), Gaps = 27/183 (14%)
Query: 216 CEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVS-RICFSPQQENGKQLLCGRGEN 274
C + C + ++ W RC R+ + S+ + IC PQ K C E+
Sbjct: 27 CSPKQFACRDQITCISKGW----RCDGERDCPDGSDEAPEIC--PQS---KAQRCQPNEH 77
Query: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDL 334
+ +C+P CNG DC D SDE +C E +C C ++ C
Sbjct: 78 NCLGTELCVPMSRLCNGVQDCMDGSDEGP-HCRELQGNCSRLGCQHH---------CVPT 127
Query: 335 SDEQNCDCNPTTE-----HRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRN 389
D C CN + + C D ++ C C + C C L++ N
Sbjct: 128 LDGPTCYCNSSFQLQADGKTCKDFDECSVYGTC--SQLCTNTDGSFICGCVEGYLLQPDN 185
Query: 390 GQC 392
C
Sbjct: 186 RSC 188
Score = 34.3 bits (77), Expect = 0.63
Identities = 14/33 (42%), Positives = 18/33 (54%), Gaps = 1/33 (3%)
Query: 655 CQDDELECANH-ACVSRDLWCDGEADCSDSSDE 686
C + C + C+S+ CDGE DC D SDE
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDE 59
Score = 31.2 bits (69), Expect = 5.3
Identities = 35/161 (21%), Positives = 52/161 (32%), Gaps = 27/161 (16%)
Query: 313 CHTG----KCLNYSLVCDGYDDCGDLS-------DEQNCDCNP-----TTEHRCGDGRCI 356
C TG KC VC GY C + S ++ C C P ++R G C
Sbjct: 4258 CPTGFTGPKCTQQ--VCAGY--CANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCE 4313
Query: 357 ---AMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEEN 413
+ DG C + C C G C+ + D +C DG +
Sbjct: 4314 NFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPS 4373
Query: 414 CSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ 454
C C G + + + C C P+ + C +
Sbjct: 4374 CLTCVGHCSNGGSCTMNSKMMPEC----QCPPHMTGPRCEE 4410
>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
Length = 1059
Score = 197 bits (500), Expect = 6e-50
Identities = 103/248 (41%), Positives = 144/248 (58%), Gaps = 8/248 (3%)
Query: 789 DCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGR 848
DCG PAA RI+GG + G WPWQ SL H CG VL+A++W+L+ AHCF+
Sbjct: 816 DCGLAPAALT--RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVY 873
Query: 849 ENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYV 908
+ W LG L Q V I HP Y+ +DYD++++EL+ + + V
Sbjct: 874 GDPKQWAAFLGTPFLSGAEG--QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLV 931
Query: 909 RPVCLPNPEQWLEPDTYCYITGWGHM--GNKMPFKLQEGEVRIISLEHCQSYFDMKTITT 966
RP+CLP P T C ITGWG + G M +LQ+ VR++S + C+ ++ ++ I++
Sbjct: 932 RPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQ-ISS 990
Query: 967 RMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYF 1026
RM+CAG+ G VDSC GD+GGPL C +P GRW L G+TSWG C + PGVY+ V+
Sbjct: 991 RMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGC-GRPHFPGVYTRVAAV 1049
Query: 1027 VEWIKRQI 1034
WI + I
Sbjct: 1050 RGWIGQHI 1057
Score = 189 bits (480), Expect = 1e-47
Identities = 94/245 (38%), Positives = 138/245 (56%), Gaps = 6/245 (2%)
Query: 789 DCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGR 848
+CG +PA RM RI+GG + PG +PWQ SL+ E H CG +I +W+++ AHCF
Sbjct: 190 ECGLQPAWRMAGRIVGGMEASPGEFPWQASLR-ENKEHFCGAAIINARWLVSAAHCFNEF 248
Query: 849 ENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYV 908
++ W +G L V I+ HP Y+ D+D++++EL+ + ++
Sbjct: 249 QDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHI 308
Query: 909 RPVCLPNPEQWLEPDTYCYITGWGHMGNKM---PFKLQEGEVRIISLEHCQSYFDMKTIT 965
+PVCLP P C I+GWG++ P LQ+ V ++ C S + ++T
Sbjct: 309 QPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYG-HSLT 367
Query: 966 TRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSY 1025
RM+CAGY G VDSC GDSGGPLVCE+P GR+ L G+ SWG C ++ PGVY+ V+
Sbjct: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGC-AEARRPGVYARVTR 426
Query: 1026 FVEWI 1030
+WI
Sbjct: 427 LRDWI 431
Score = 171 bits (433), Expect = 3e-42
Identities = 94/246 (38%), Positives = 141/246 (57%), Gaps = 7/246 (2%)
Query: 788 QDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEG 847
Q+CG RPA R++GG + G PWQ SL+ E S H CG ++ +W+L+ AHCF
Sbjct: 490 QECGARPAMEKPTRVVGGFGAASGEVPWQVSLK-EGSRHFCGATVVGDRWLLSAAHCFNH 548
Query: 848 RENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGY 907
+ V + LG +L ++ ++LHP Y+ ++D+D++++EL+ ++ Y
Sbjct: 549 TKVEQV-RAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607
Query: 908 VRPVCLPNPEQWLEPDTYCYITGWGHM--GNKM-PFKLQEGEVRIISLEHCQSYFDMKTI 964
++PVCLP Q C I+GWG+ GN P LQ+ V II + C ++ ++
Sbjct: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNF-SL 666
Query: 965 TTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVS 1024
T RMICAG+ G VDSC GDSGGPL CE+ G + L G+ SWG C ++V PGVY+ ++
Sbjct: 667 TDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGC-AQVKKPGVYTRIT 725
Query: 1025 YFVEWI 1030
WI
Sbjct: 726 RLKGWI 731
Score = 42.4 bits (98), Expect = 0.002
Identities = 18/44 (40%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 580 CSPSHFKCRSGQCVL-ASRRCDGQADCDDDSDEENCGCKERDLW 622
C + F C + QCV + CD Q DC D SDE +C C + W
Sbjct: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQPAW 197
Score = 37.7 bits (86), Expect = 0.057
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 272 GENFLCASGICIPG-KLQCNGYNDCDDWSDEAHCNC 306
G +F C + C+ +C+ DC D SDEAHC C
Sbjct: 156 GNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCEC 191
Score = 37.7 bits (86), Expect = 0.057
Identities = 15/29 (51%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Query: 387 CRNGQCIPSTF-QCDGDEDCKDGSDEENC 414
C N QC+ +CD EDC DGSDE +C
Sbjct: 161 CGNSQCVTKVNPECDDQEDCSDGSDEAHC 189
Score = 36.6 bits (83), Expect = 0.13
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 306 CSENLFHCHTGKCLN-YSLVCDGYDDCGDLSDEQNCDC 342
C N F C +C+ + CD +DC D SDE +C+C
Sbjct: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCEC 191
Score = 35.8 bits (81), Expect = 0.22
Identities = 15/40 (37%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 344 PTTEHRCGDGRCIA-MEWVCDGDHDCVDKSDEVNCSCHSQ 382
P CG+ +C+ + CD DC D SDE +C C Q
Sbjct: 155 PGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQ 194
Score = 35.4 bits (80), Expect = 0.28
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 655 CQDDELECANHACVSR-DLWCDGEADCSDSSDEWDC 689
C + C N CV++ + CD + DCSD SDE C
Sbjct: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC 189
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 196 bits (498), Expect = 1e-49
Identities = 153/517 (29%), Positives = 211/517 (40%), Gaps = 123/517 (23%)
Query: 202 DGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQ 261
DG D L P R FC + C N + P L C+ +N + S+ R+
Sbjct: 3540 DGSDELALCPQR-FCRLGQFQCSDG----NCTSPQTL-CNAHQNCPDGSDEDRLLCENHH 3593
Query: 262 ENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDE--AHC---NCSENLFHCHTG 316
C E + CA+ CIP QC+ +NDC+D SDE +HC C F C G
Sbjct: 3594 -------CDSNE-WQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANG 3645
Query: 317 KCLNYSLVCDGYDDCGDLSDE--QNCD-----CNPTTEHRCGDG-RCIAMEWVCDGDHDC 368
+C+ + CD +DCGD SDE + C C+ TE C RCI VC+G DC
Sbjct: 3646 RCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDC 3705
Query: 369 VDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGD 425
D SDE C +CH G C+N CIP +QCDG DC D SDEENC+ C E +
Sbjct: 3706 RDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA--PRECTESE 3763
Query: 426 QRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEA 485
RC+ C+ S +CD N + S + C +P Y
Sbjct: 3764 FRCVNQQCIPS---RWICDHYNDCGDNSDERDCEMRTC---------HPEY--------- 3802
Query: 486 SISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLG 545
F CT C HS+ +C+
Sbjct: 3803 -----------------------FQCT-----------------SGHCVHSELKCDGSAD 3822
Query: 546 IVGLQWPEDTDC-SQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQAD 604
L ++ DC ++FP+ C + F+C++ C+ +CDG D
Sbjct: 3823 C--LDASDEADCPTRFPDG--------------AYCQATMFECKNHVCIPPYWKCDGDDD 3866
Query: 605 CDDDSDEE-----NCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDE--KNCSF--- 654
C D SDEE + C + + C +N+ C+ +C+G DC D DE ++C
Sbjct: 3867 CGDGSDEELHLCLDVPCNSPNRFRCDNNR-CIYSHEVCNGVDDCGDGTDETEEHCRKPTP 3925
Query: 655 --CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
C + E +C N C+ D CD DC D SDE C
Sbjct: 3926 KPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
Score = 181 bits (459), Expect = 3e-45
Identities = 141/453 (31%), Positives = 189/453 (41%), Gaps = 95/453 (20%)
Query: 275 FLCASGI-CIPGKLQCNGYNDCDDWSDE-AHCN---CSENLFHCHTGKCLNYSLVCDGYD 329
FLCA+ CIP +C+G DC D SDE A C C F C G C + +C+ +
Sbjct: 3517 FLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQ 3576
Query: 330 DCGDLSDEQNCDCN----PTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQ--- 382
+C D SDE C + E +C + RCI W CD +DC D SDE + C S+
Sbjct: 3577 NCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCR 3636
Query: 383 -GLVECRNGQCIPSTFQCDGDEDCKDGSDE--ENC--------SVIQTSCQEGDQRCLYN 431
G C NG+CIP ++CD D DC D SDE E C + + SC+ + RC+
Sbjct: 3637 PGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKT-NYRCI-- 3693
Query: 432 PCLDSCGGSSLCDPNNSLNNCSQ--CEPITLELCMN---LPYN-STSYPNYFGHRTQKEA 485
P C G C N+ C + C P+ C N +P N G + +E
Sbjct: 3694 PKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEE- 3752
Query: 486 SISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLG 545
NC CT +C + P R +C+H
Sbjct: 3753 ---------------NCAPR----ECTESEFRC---VNQQCIPSRWICDHY--------- 3781
Query: 546 IVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADC 605
DC +NSD + C M C P +F+C SG CV + +CDG ADC
Sbjct: 3782 ---------NDCG----DNSDERDCEM-----RTCHPEYFQCTSGHCVHSELKCDGSADC 3823
Query: 606 DDDSDEENCGCKERDLWECPSNK-QCLKHTVI-----CDGFPDCPDYMDEKNCSFCQD-- 657
D SDE +C + D C + +C H I CDG DC D DE+ C D
Sbjct: 3824 LDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE-LHLCLDVP 3882
Query: 658 ----DELECANHACVSRDLWCDGEADCSDSSDE 686
+ C N+ C+ C+G DC D +DE
Sbjct: 3883 CNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Score = 168 bits (425), Expect = 3e-41
Identities = 126/433 (29%), Positives = 188/433 (43%), Gaps = 65/433 (15%)
Query: 306 CSENLFHC-HTGKCLNYSLVCDGYDDCGDLSDE------QNCDCNPTTEHRCGDGRCIAM 358
CS F C + KC+ CDG DC D SDE + C + +C DG C +
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG---QFQCSDGNCTSP 3568
Query: 359 EWVCDGDHDCVDKSDEVNCSCHSQGLV----ECRNGQCIPSTFQCDGDEDCKDGSDEENC 414
+ +C+ +C D SDE C + +C N +CIP ++QCD DC+D SDE++
Sbjct: 3569 QTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSS 3628
Query: 415 SVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYP 474
+C+ G RC C+ CD +N + S EPI E CM+ + ++
Sbjct: 3629 HCASRTCRPGQFRCANGRCIPQAWK---CDVDNDCGDHSD-EPI--EECMSSAHLCDNFT 3682
Query: 475 NYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCE 534
+ +TN Y+ + ++ V C N+ E R
Sbjct: 3683 EFS--------------------CKTN-YRCIPKWAVCNGVDDCRDNSDEQGCEERTCHP 3721
Query: 535 HSKERCESVLGIVGLQWPED--TDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQC 592
RC++ + L+W D DC +NSD + C EC+ S F+C + QC
Sbjct: 3722 VGDFRCKNH-HCIPLRWQCDGQNDCG----DNSDEENCAP-----RECTESEFRCVNQQC 3771
Query: 593 VLASRRCDGQADCDDDSDEENCGCK--ERDLWECPSNKQCLKHTVICDGFPDCPDYMDEK 650
+ + CD DC D+SDE +C + + ++C S C+ + CDG DC D DE
Sbjct: 3772 IPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSG-HCVHSELKCDGSADCLDASDEA 3830
Query: 651 NC-------SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLM 703
+C ++CQ EC NH C+ CDG+ DC D SDE + L + NS +
Sbjct: 3831 DCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFR 3890
Query: 704 V--HRAATEHHVC 714
+R H VC
Sbjct: 3891 CDNNRCIYSHEVC 3903
Score = 164 bits (416), Expect = 3e-40
Identities = 146/520 (28%), Positives = 211/520 (40%), Gaps = 99/520 (19%)
Query: 212 CRSFCEAAKEGCESVLGMVNYSWPDFLRCS-QFRNQTESSNVSRICFSPQQENGKQLLCG 270
C + CE GC + P+ C +N + C +NG++ CG
Sbjct: 2651 CNNPCEQFNGGCSHICA----PGPNGAECQCPHEGNWYLANNRKHCIV---DNGER--CG 2701
Query: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC-----NCSENLFHCHTGKCLNYSLVC 325
+F C++G CI + +C+ NDC D SDE CS F C G+C+ YS C
Sbjct: 2702 -ASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC 2760
Query: 326 DGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDK--SDEVNC--- 377
D Y+DCGD SDE C DCN TTE C + RCI E++C+G +C D SDE NC
Sbjct: 2761 DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR 2820
Query: 378 SCHSQGLVECRNGQ-CIPSTFQCDGDEDCKDGSDEE-------NCSVIQTSCQEGDQRCL 429
+C S G +C N CIP + CDGD DC D SDE CS + C G RC+
Sbjct: 2821 TCQS-GYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG--RCI 2877
Query: 430 --------YNPCLD------SCGGSS--------------------LCDPNNSLNNCS-- 453
C D SCG S +CD +N + S
Sbjct: 2878 PQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Query: 454 ----QCEPITLE----LCMN-LPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYK 504
QC+ LC+N P + P + + + ++ + + C +
Sbjct: 2938 DKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN--QNCTRRTCSE 2995
Query: 505 YLMFFSCTILVPK---CDVNT--GEHIPPCRAL---CEHSKERCESVLGIVG-LQWPEDT 555
+ +PK CD + G++ L C+ ++ C++ I ED
Sbjct: 2996 NEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDN 3055
Query: 556 DCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG 615
DC +E C P+ C P FKC +G+C+ + C+ DC D+SDE+ CG
Sbjct: 3056 DCGDGSDELM--HLCHTPEP---TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCG 3110
Query: 616 ---CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC 652
C + + C N + C P D++ C
Sbjct: 3111 INECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150
Score = 162 bits (410), Expect = 2e-39
Identities = 128/439 (29%), Positives = 176/439 (40%), Gaps = 67/439 (15%)
Query: 253 SRICFSPQQENGK-QLLCGRGENFLCASGICIPGKLQCNGYNDC--DDWSDEAHCNCSEN 309
S C P NG C NF G C G + + C D ++ C
Sbjct: 971 SNACNQPTHPNGDCSHFCFPVPNFQRVCG-CPYGMRLASNHLTCEGDPTNEPPTEQCGLF 1029
Query: 310 LFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC----DCNPTTEHRCGDGRCIAMEWVCDGD 365
F C G+C+ +CDG DDC D SDEQ C + ++ CG G CI W CD
Sbjct: 1030 SFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKR 1089
Query: 366 HDCVDKSDEVNCSCHSQG-----LVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS 420
+DCVD SDE NC H+ C N QCI + CD D DC DGSDE+NC+ +T
Sbjct: 1090 NDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET- 1148
Query: 421 CQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHR 480
CQ C + C+D S +CD + + S L C + S G
Sbjct: 1149 CQPSQFNCPNHRCIDL---SFVCDGDKDCVDGSDEVGCVLN-CTASQFKCASGDKCIGVT 1204
Query: 481 TQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCR--ALCEHSKE 538
+ + V C N+ E P R +C +
Sbjct: 1205 NRCDG-----------------------------VFDCSDNSDEAGCPTRPPGMCHSDEF 1235
Query: 539 RCESVLGIVGLQWPEDTDCSQFPE--ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLAS 596
+C+ G+ P +C P+ SD +P + C S+F C +G C+ +
Sbjct: 1236 QCQE----DGICIPNFWECDGHPDCLYGSDEHNACVP----KTCPSSYFHCDNGNCIHRA 1287
Query: 597 RRCDGQADCDDDSDEENCGCKERDL----WECPSNKQCLKHTVICDGFPDCPDYMDEK-- 650
CD DC D SDE++C + W+C + C+ +V+CDG DCP+ DE
Sbjct: 1288 WLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL 1347
Query: 651 -NCSFCQDDELECANHACV 668
N + C D C H CV
Sbjct: 1348 CNGNSCSDFNGGC-THECV 1365
Score = 152 bits (384), Expect = 2e-36
Identities = 104/334 (31%), Positives = 147/334 (44%), Gaps = 75/334 (22%)
Query: 338 QNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHS--QGLVECRN-GQCIP 394
Q CD + RCG G CI +W CDG DC D +DE+ C+ + QG +C++ GQCIP
Sbjct: 26 QECD---SAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIP 82
Query: 395 STFQCDGDEDCKDGSDE-ENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLN 450
+++ CD D+DC DGSDE ++CS Q++C C C+ S C C N
Sbjct: 83 NSWVCDQDQDCDDGSDERQDCS--QSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADEN 140
Query: 451 NCSQ--CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMF 508
+C CE +T + N Y + +QK W+ + + NC + +
Sbjct: 141 DCQYPTCEQLTCD-------NGACY-----NTSQK---CDWKVDCRDSSDEINCTEICLH 185
Query: 509 --FSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSD 566
FSC GE IP +C+H D DC ++ SD
Sbjct: 186 NEFSC---------GNGECIPRAY-VCDH------------------DNDC----QDGSD 213
Query: 567 NQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDL----- 621
C P C F C SG+C+ + CDG+ DC D+ DE+ C D+
Sbjct: 214 EHACNYPT-----CGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSP 268
Query: 622 --WECPSNKQCLKHTVICDGFPDCPDYMDEKNCS 653
W CP + +C+ +CDG DCP DE N S
Sbjct: 269 REWSCPESGRCISIYKVCDGILDCPGREDENNTS 302
Score = 149 bits (377), Expect = 1e-35
Identities = 135/472 (28%), Positives = 194/472 (41%), Gaps = 86/472 (18%)
Query: 279 SGICIPG----KLQCNGYNDCDDWSDEAHC------NCSENLFHCHTGKCLNYSLVCDGY 328
S IC PG + QC + ++ HC C + F C G+C++ CD
Sbjct: 2663 SHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDND 2722
Query: 329 DDCGDLSDEQNC-----DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC---SCH 380
+DCGD SDE C+PT C +GRC+ + CD +DC D SDE C C+
Sbjct: 2723 NDCGDGSDEMESVCALHTCSPTA-FTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCN 2781
Query: 381 SQGLVECRNGQCIPSTFQCDGDEDCKDG--SDEENCSVIQTSCQEGDQRC----LYNPCL 434
+ C N +CIP F C+G ++C D SDE+NC +CQ G +C + P +
Sbjct: 2782 ATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCP--DRTCQSGYTKCHNSNICIPRV 2839
Query: 435 DSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLF 494
C G + C +NS N + C T C + + S H + + +++S
Sbjct: 2840 YLCDGDNDCG-DNSDENPTYC---TTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Query: 495 PALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALC-----------EHSKERCE-- 541
PA +C +C KCD G P +C E + +C+
Sbjct: 2896 PA----SCGHSER--TCLADEFKCD---GGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQ 2946
Query: 542 ----SVLGIVGLQWPE------------DTDCSQFPEENSDNQTCLMPDEYVEECSPSHF 585
S V + P+ D DC+ +EN Q C CS + F
Sbjct: 2947 NCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN---QNCTR-----RTCSENEF 2998
Query: 586 KCRSGQCVLASRRCDGQADCDDDSDEENCGCK--ERDLWECPSNKQCLKHTVICDGFPDC 643
C G C+ RCD DC D SDE C + +++ + C N +C+ T +CD DC
Sbjct: 2999 TCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTC-QNGRCISKTFVCDEDNDC 3057
Query: 644 PDYMDEKN--CSF----CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
D DE C C E +C N C+ C+ DC D+SDE C
Sbjct: 3058 GDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Score = 139 bits (351), Expect = 1e-32
Identities = 127/497 (25%), Positives = 193/497 (38%), Gaps = 139/497 (27%)
Query: 286 KLQCNGYNDCDDWS-----------DEAHCNC--------SENLFHCHTGKCLNYSLVCD 326
K QCN N C+ ++ + A C C + N HC + D
Sbjct: 2648 KQQCN--NPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHC----------IVD 2695
Query: 327 GYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVN--CSCH--SQ 382
+ CG + C +GRCI+ EW CD D+DC D SDE+ C+ H S
Sbjct: 2696 NGERCG------------ASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSP 2743
Query: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV----IQTSCQEGDQRCLYNPCLDSCG 438
C NG+C+ +++CD DC DGSDE C T ++RC+ + C
Sbjct: 2744 TAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFI--CN 2801
Query: 439 GSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALV 498
G C NN+ + N P + T Y
Sbjct: 2802 GVDNCHDNNTSDE------------KNCP-DRTCQSGY---------------------- 2826
Query: 499 QTNCYKYLMFFSCTILVPK---------CDVNTGEHIPPCRA-LCEHSKERCESVLGIVG 548
T C+ + I +P+ C N+ E+ C C S+ +C S +
Sbjct: 2827 -TKCH------NSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGR-CIP 2878
Query: 549 LQW--PEDTDCSQFPEENSD----NQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQ 602
W ++TDC +E + +TCL + FKC G+C+ + CDG
Sbjct: 2879 QHWYCDQETDCFDASDEPASCGHSERTCLADE----------FKCDGGRCIPSEWICDGD 2928
Query: 603 ADCDDDSDE------ENCGCKERDLW---ECPSNKQCLKHTVICDGFPDCPDYMDE-KNC 652
DC D SDE +N C + + + P +++C+ + +CDG DC D DE +NC
Sbjct: 2929 NDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNC 2988
Query: 653 S--FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVN-----SSSFLMVH 705
+ C ++E C C+ + CD DC D SDE C+ + N + +
Sbjct: 2989 TRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKT 3048
Query: 706 RAATEHHVCADGWQEIL 722
E + C DG E++
Sbjct: 3049 FVCDEDNDCGDGSDELM 3065
Score = 130 bits (327), Expect = 6e-30
Identities = 100/374 (26%), Positives = 150/374 (40%), Gaps = 68/374 (18%)
Query: 339 NCDCN------PTTEHRCG---DGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRN 389
N DC+ P + CG R + C+GD +++ C S C+N
Sbjct: 981 NGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQ--CGLFS---FPCKN 1035
Query: 390 GQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPN 446
G+C+P+ + CDG +DC D SDE+ C + +C C + C+ + C + C
Sbjct: 1036 GRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDG 1095
Query: 447 NSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYL 506
+ +NC P + C++ Y ++ K ++ + NC
Sbjct: 1096 SDEHNCPTHAPAS---CLDTQYTCDNH-----QCISKNWVCDTDNDCGDGSDEKNC---- 1143
Query: 507 MFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSD 566
N+ E P + C + RC + + D DC + SD
Sbjct: 1144 --------------NSTETCQPSQFNCPN--HRCIDLSFVC----DGDKDC----VDGSD 1179
Query: 567 NQTCLMPDEYVEECSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENC-----GCKERD 620
C++ C+ S FKC SG +C+ + RCDG DC D+SDE C G D
Sbjct: 1180 EVGCVL------NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSD 1233
Query: 621 LWECPSNKQCLKHTVICDGFPDCPDYMDEKNC---SFCQDDELECANHACVSRDLWCDGE 677
++C + C+ + CDG PDC DE N C C N C+ R CD +
Sbjct: 1234 EFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRD 1293
Query: 678 ADCSDSSDEWDCVT 691
DC D SDE DC T
Sbjct: 1294 NDCGDMSDEKDCPT 1307
Score = 125 bits (314), Expect = 2e-28
Identities = 73/210 (34%), Positives = 97/210 (46%), Gaps = 19/210 (9%)
Query: 256 CFSPQQENGKQLLCGRGENFLCAS-GICIPGKLQCNGYNDCDDWSDE----AHCNCSENL 310
C E G ++ + F C S G CIP C+ DCDD SDE + CS +
Sbjct: 53 CSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQ 112
Query: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVD 370
C G+C+ CD DC D +DE +C + C +G C CD DC D
Sbjct: 113 ITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRD 172
Query: 371 KSDEVNCS---CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV-----IQTSCQ 422
SDE+NC+ H++ C NG+CIP + CD D DC+DGSDE C+ Q +C
Sbjct: 173 SSDEINCTEICLHNE--FSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCP 230
Query: 423 EGDQRCLYNPCLDSCGGSSLCDPNNSLNNC 452
G RC+Y + C G C N + C
Sbjct: 231 SG--RCIYQNWV--CDGEDDCKDNGDEDGC 256
Score = 123 bits (308), Expect = 1e-27
Identities = 68/187 (36%), Positives = 98/187 (52%), Gaps = 13/187 (6%)
Query: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHT-GKCLNYSLVCDGYD 329
+F C SG CIP +C+G DC D +DE C C + F C + G+C+ S VCD
Sbjct: 32 HFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQ 91
Query: 330 DCGDLSDE-QNCDCNPTTEHR--CGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVE 386
DC D SDE Q+C + + H+ C +G+CI E+ CD DC D +DE +C + +
Sbjct: 92 DCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLT 151
Query: 387 CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPN 446
C NG C ++ +CD DC+D SDE NC+ I C + C C+ + +CD +
Sbjct: 152 CDNGACYNTSQKCDWKVDCRDSSDEINCTEI---CLHNEFSCGNGECIPR---AYVCDHD 205
Query: 447 NSLNNCS 453
N + S
Sbjct: 206 NDCQDGS 212
Score = 106 bits (264), Expect = 1e-22
Identities = 59/148 (39%), Positives = 73/148 (49%), Gaps = 17/148 (11%)
Query: 563 ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC------GC 616
+NSD Q C CS S F C G+C+ A RCD + DC D SDE NC C
Sbjct: 1053 DNSDEQLC---GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASC 1109
Query: 617 KERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF---CQDDELECANHACVSRDLW 673
+ + C N QC+ +CD DC D DEKNC+ CQ + C NH C+
Sbjct: 1110 LDTQ-YTC-DNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFV 1167
Query: 674 CDGEADCSDSSDEWDCVTLSINVNSSSF 701
CDG+ DC D SDE CV +N +S F
Sbjct: 1168 CDGDKDCVDGSDEVGCV---LNCTASQF 1192
Score = 102 bits (254), Expect = 2e-21
Identities = 49/125 (39%), Positives = 70/125 (56%), Gaps = 6/125 (4%)
Query: 570 CLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK--ERDLWECPSN 627
CL P +EC +HF+C SG C+ A RCDG DC DD+DE C ++ ++C S
Sbjct: 19 CLAPASG-QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSE 77
Query: 628 KQCLKHTVICDGFPDCPDYMDEK-NC--SFCQDDELECANHACVSRDLWCDGEADCSDSS 684
QC+ ++ +CD DC D DE+ +C S C ++ C+N C+ + CD DC D +
Sbjct: 78 GQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGA 137
Query: 685 DEWDC 689
DE DC
Sbjct: 138 DENDC 142
Score = 100 bits (249), Expect = 7e-21
Identities = 76/221 (34%), Positives = 99/221 (44%), Gaps = 21/221 (9%)
Query: 256 CFSPQQENGKQLLCGRGENFLCASGI-CIPGKLQCNGYNDCDDWSDEAHC------NCSE 308
C E G L C + F CASG CI +C+G DC D SDEA C C
Sbjct: 1174 CVDGSDEVGCVLNCTASQ-FKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHS 1232
Query: 309 NLFHC-HTGKCLNYSLVCDGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDG 364
+ F C G C+ CDG+ DC SDE N P++ C +G CI W+CD
Sbjct: 1233 DEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDR 1292
Query: 365 DHDCVDKSDEVNC-----SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEEN-CSVIQ 418
D+DC D SDE +C C S + C+ + CDG DC +G+DE C+
Sbjct: 1293 DNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCN--G 1350
Query: 419 TSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ-CEPI 458
SC + + C + + G LC L N S+ CE I
Sbjct: 1351 NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDI 1391
Score = 97.8 bits (242), Expect = 5e-20
Identities = 81/315 (25%), Positives = 130/315 (41%), Gaps = 66/315 (20%)
Query: 387 CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYN-PCLDS---CGGSSL 442
C +G CIP+ ++CDG +DC D +DE C+V+ +CQ+G +C C+ + C
Sbjct: 35 CGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQCIPNSWVCDQDQD 92
Query: 443 CDP-NNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTN 501
CD ++ +CSQ + ++ + N P+ + ++ P N
Sbjct: 93 CDDGSDERQDCSQSTCSSHQITCS---NGQCIPSEYRCDHVRDC---------PDGADEN 140
Query: 502 CYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFP 561
+Y P C+ T ++ C ++ ++C+ W DC
Sbjct: 141 DCQY----------PTCEQLTCDN-----GACYNTSQKCD---------WK--VDC---- 170
Query: 562 EENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDL 621
++SD C E C + F C +G+C+ + CD DC D SDE C
Sbjct: 171 RDSSDEINC------TEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGG 224
Query: 622 WE--CPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECA--------NHACVSRD 671
++ CPS + C+ +CDG DC D DE C D +C+ + C+S
Sbjct: 225 YQFTCPSGR-CIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIY 283
Query: 672 LWCDGEADCSDSSDE 686
CDG DC DE
Sbjct: 284 KVCDGILDCPGREDE 298
Score = 97.8 bits (242), Expect = 5e-20
Identities = 49/115 (42%), Positives = 60/115 (52%), Gaps = 11/115 (9%)
Query: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHTGKCLNYSLVCDGYDDC 331
F C +G CIP C+ NDC D SDE CN C F C +G+C+ + VCDG DDC
Sbjct: 188 FSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDC 247
Query: 332 GDLSDEQNCDCNPTTEHRCG--------DGRCIAMEWVCDGDHDCVDKSDEVNCS 378
D DE C+ P H+C GRCI++ VCDG DC + DE N S
Sbjct: 248 KDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTS 302
Score = 90.9 bits (224), Expect = 6e-18
Identities = 51/160 (31%), Positives = 68/160 (42%), Gaps = 12/160 (7%)
Query: 533 CEHSKERCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSG 590
C+ +C+S + W +D DC +E D CS C +G
Sbjct: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQ--------STCSSHQITCSNG 118
Query: 591 QCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEK 650
QC+ + RCD DC D +DE +C + C N C + CD DC D DE
Sbjct: 119 QCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTC-DNGACYNTSQKCDWKVDCRDSSDEI 177
Query: 651 NCS-FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
NC+ C +E C N C+ R CD + DC D SDE C
Sbjct: 178 NCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Score = 56.2 bits (134), Expect = 2e-07
Identities = 51/191 (26%), Positives = 72/191 (37%), Gaps = 25/191 (13%)
Query: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC--------NCSENLFHC-HTGKCL 319
CG G F C SG CI C+G +DC D DE C CS + C +G+C+
Sbjct: 222 CG-GYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCI 280
Query: 320 NYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSC 379
+ VCDG DC DE N +T C C A+ + + C + C C
Sbjct: 281 SIYKVCDGILDCPGREDEN----NTSTGKYCSMTLCSAL----NCQYQCHETPYGGACFC 332
Query: 380 HSQGLVECRNGQCIPSTFQCD----GDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLD 435
++ + + C D+ C+ C + E Q C N D
Sbjct: 333 PPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKAN---D 389
Query: 436 SCGGSSLCDPN 446
S G +S+ N
Sbjct: 390 SFGEASIIFSN 400
Score = 47.8 bits (112), Expect = 6e-05
Identities = 31/104 (29%), Positives = 43/104 (41%), Gaps = 12/104 (11%)
Query: 624 CPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDS 683
CP + + + C+G P +E C C N CV CDG DC D+
Sbjct: 1000 CPYGMRLASNHLTCEGDPT-----NEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDN 1054
Query: 684 SDEWDCVTLSINVNSSSF-------LMVHRAATEHHVCADGWQE 720
SDE C TL+ +SS+F + H + + C DG E
Sbjct: 1055 SDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 1098
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 196 bits (497), Expect = 1e-49
Identities = 128/374 (34%), Positives = 188/374 (50%), Gaps = 31/374 (8%)
Query: 666 ACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHH--VCADGWQEILS 723
+C + CDG DC SDE CV + S L ++ ++ +C+ W + S
Sbjct: 203 SCPKHAVRCDGVVDCKLKSDELGCVRFDWD---KSLLKIYSGSSHQWLPICSSNWNDSYS 259
Query: 724 QLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISL 783
+ C+Q+G T + ++ + L N +T+ E L + C S+ ISL
Sbjct: 260 EKTCQQLGFESAHRTTEVAHRDFANSFSILRYN------STIQESLHRSE-CPSQRYISL 312
Query: 784 LCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAH 843
C+ CG R M RI+GG + +WPWQ SL + HICG LI +WVLT AH
Sbjct: 313 QCSH--CGLRA---MTGRIVGGALASDSKWPWQVSLHFGTT-HICGGTLIDAQWVLTAAH 366
Query: 844 CFEGRENAAV--WKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSED 901
CF + WKV G +NL + + II++ Y+ DYDI+++ LS+
Sbjct: 367 CFFVTREKVLEGWKVYAGTSNLHQ---LPEAASIAEIIINSNYTDEEDDYDIALMRLSKP 423
Query: 902 ISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM----GNKMPFKLQEGEVRIISLEHCQS 957
++ + ++ P CLP Q + C+ITG+G PF L+E +V +I + C
Sbjct: 424 LTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCND 482
Query: 958 YFDMKT-ITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLG 1016
Y + +T RM+CAG G DSC GDSGGPLVCE+ RW L G+TSWG+ C +
Sbjct: 483 YLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQR-NK 540
Query: 1017 PGVYSNVSYFVEWI 1030
PGVY+ V+ + WI
Sbjct: 541 PGVYTKVTEVLPWI 554
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sapiens]
Length = 454
Score = 193 bits (491), Expect = 6e-49
Identities = 123/379 (32%), Positives = 198/379 (52%), Gaps = 26/379 (6%)
Query: 667 CVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLA 726
C+ CDG +DC D DE+ CV + ++ L V AA+ +C+D W+ + +A
Sbjct: 85 CIELIARCDGVSDCKDGEDEYRCVRVG---GQNAVLQVFTAASWKTMCSDDWKGHYANVA 141
Query: 727 CKQMG----LGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKIS 782
C Q+G + ++ E + ++++ T LH + + C S ++
Sbjct: 142 CAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVT 201
Query: 783 LLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVA 842
L CT CG R + RI+GG S +WPWQ SLQ + H+CG +I W++T A
Sbjct: 202 LQCTA--CGHRRG--YSSRIVGGNMSLLSQWPWQASLQFQ-GYHLCGGSVITPLWIITAA 256
Query: 843 HCFEGRENAAVWKVVLG-INNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSED 901
HC W + +G ++ LD+P+ + V+ I+ H +Y + DI++++L+
Sbjct: 257 HCVYDLYLPKSWTIQVGLVSLLDNPA---PSHLVEKIVYHSKYKPKRLGNDIALMKLAGP 313
Query: 902 ISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM----GNKMPFKLQEGEVRIISLEHCQS 957
++ ++PVCLPN E+ C+ +GWG G+ P L V +IS + C +
Sbjct: 314 LTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPV-LNHAAVPLISNKIC-N 371
Query: 958 YFDMK--TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVL 1015
+ D+ I+ M+CAGY +G VDSC GDSGGPLVC++ W L G TS+G C ++V
Sbjct: 372 HRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGC-AEVN 429
Query: 1016 GPGVYSNVSYFVEWIKRQI 1034
PGVY+ V+ F++WI Q+
Sbjct: 430 KPGVYTRVTSFLDWIHEQM 448
Score = 36.6 bits (83), Expect = 0.13
Identities = 16/33 (48%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 383 GLVECRNG-QCIPSTFQCDGDEDCKDGSDEENC 414
G CR+ +CI +CDG DCKDG DE C
Sbjct: 75 GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
Score = 35.8 bits (81), Expect = 0.22
Identities = 16/37 (43%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 579 ECSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENC 614
+CS ++CRS +C+ RCDG +DC D DE C
Sbjct: 72 DCS-GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
Score = 31.6 bits (70), Expect = 4.1
Identities = 15/39 (38%), Positives = 19/39 (48%), Gaps = 2/39 (5%)
Query: 303 HCNCSENLFHCHTG-KCLNYSLVCDGYDDCGDLSDEQNC 340
H +CS + C + KC+ CDG DC D DE C
Sbjct: 70 HFDCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 187 bits (476), Expect = 3e-47
Identities = 95/238 (39%), Positives = 141/238 (59%), Gaps = 6/238 (2%)
Query: 797 RMNKRILGGRTSRPGRWPWQCSLQSEPSG--HICGCVLIAKKWVLTVAHCFEGRENAAVW 854
+ + RI+GG S G WPWQ SLQ + + H+CG LI +WVLT AHCF+G VW
Sbjct: 386 KTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVW 445
Query: 855 KVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLP 914
++ GI NL + +K II+H Y + ++DI++++L ++ T + +P+CLP
Sbjct: 446 RIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLP 505
Query: 915 NPEQWLEPDTYCYITGWGHMGNKMPFK--LQEGEVRIISLEHCQSYFDMKTITTRMICAG 972
+ T C++TGWG K + LQ+ + +++ E CQ + IT RM+CAG
Sbjct: 506 SKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAG 565
Query: 973 YESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWI 1030
Y+ G D+C GDSGGPLVC K G W L G+TSWG C ++ PGVY+ V+ +++WI
Sbjct: 566 YKEGGKDACKGDSGGPLVC-KHNGMWRLVGITSWGEGC-ARREQPGVYTKVAEYMDWI 621
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 186 bits (473), Expect = 8e-47
Identities = 133/411 (32%), Positives = 187/411 (45%), Gaps = 89/411 (21%)
Query: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDCV---TLSINVNSSSFLMVHRAATEH 711
C + L N CV CDG DC + DE +CV T +S+ +
Sbjct: 458 CPGEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPK------ 508
Query: 712 HVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVN 771
VC DG + L+ +Q G P T Q
Sbjct: 509 -VC-DGQPDCLNGSDEEQCQEGVPCGTFTFQ----------------------------- 537
Query: 772 GQSCESRSKISLLCTKQ---DCGRRPAAR--------------MNKRILGGRTSRPGRWP 814
CE RS C K+ C RP R + RI+GG S G WP
Sbjct: 538 ---CEDRS-----CVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWP 589
Query: 815 WQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAA--VWKVVLGINNLDHPSVFMQT 872
WQ SLQ HICG LIA +WV+T AHCF+ A+ +W V LG V+ +
Sbjct: 590 WQASLQVR-GRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLG-------KVWQNS 641
Query: 873 RF-------VKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTY 925
R+ V ++LHP + DYD+++++L + + VRPVCLP + EP +
Sbjct: 642 RWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLH 701
Query: 926 CYITGWGHM--GNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMG 983
C+ITGWG + G + LQ+ +V++I + C + + +T RM+CAGY G D+C G
Sbjct: 702 CWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQ-VTPRMLCAGYRKGKKDACQG 760
Query: 984 DSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034
DSGGPLVC+ GRW L GL SWG C + GVY+ ++ + WI++ +
Sbjct: 761 DSGGPLVCKALSGRWFLAGLVSWGLGC-GRPNYFGVYTRITGVISWIQQVV 810
Score = 79.3 bits (194), Expect = 2e-14
Identities = 51/149 (34%), Positives = 72/149 (48%), Gaps = 23/149 (15%)
Query: 274 NFLCASGICIPG-KLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCG 332
NF + PG ++ YN D E C+ + G C+ CDG DC
Sbjct: 433 NFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVN--------GLCVP---ACDGVKDCP 481
Query: 333 DLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGL------VE 386
+ DE+NC C T + + D CI++ VCDG DC++ SDE C +G+ +
Sbjct: 482 NGLDERNCVCRATFQCK-EDSTCISLPKVCDGQPDCLNGSDEEQCQ---EGVPCGTFTFQ 537
Query: 387 CRNGQCIPSTF-QCDGDEDCKDGSDEENC 414
C + C+ QCDG DC+DGSDEE+C
Sbjct: 538 CEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
Score = 79.0 bits (193), Expect = 2e-14
Identities = 43/113 (38%), Positives = 57/113 (50%), Gaps = 10/113 (8%)
Query: 582 PSHFKCR-SGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGF 640
P F C +G CV A CDG DC + DE NC C R ++C + C+ +CDG
Sbjct: 459 PGEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVC--RATFQCKEDSTCISLPKVCDGQ 513
Query: 641 PDCPDYMDEKNCSF---CQDDELECANHACVSR-DLWCDGEADCSDSSDEWDC 689
PDC + DE+ C C +C + +CV + + CDG DC D SDE C
Sbjct: 514 PDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
Score = 75.5 bits (184), Expect = 2e-13
Identities = 43/115 (37%), Positives = 57/115 (49%), Gaps = 10/115 (8%)
Query: 275 FLCA-SGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGD 333
FLC+ +G+C+P C+G DC + DE +C C C++ VCDG DC +
Sbjct: 462 FLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLN 518
Query: 334 LSDEQNCD----CNPTTEHRCGDGRCIAM-EWVCDGDHDCVDKSDEVNCSCHSQG 383
SDE+ C C T +C D C+ CDG DC D SDE +C C QG
Sbjct: 519 GSDEEQCQEGVPCG-TFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQG 572
Score = 48.1 bits (113), Expect = 4e-05
Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 10/107 (9%)
Query: 518 CDVNTGEHIPPCRAL--CEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCL--MP 573
C VN G +P C + C + + V Q ED+ C P+ CL
Sbjct: 464 CSVN-GLCVPACDGVKDCPNGLDERNCVCRAT-FQCKEDSTCISLPKVCDGQPDCLNGSD 521
Query: 574 DEYVEE---CSPSHFKCRSGQCVLASR-RCDGQADCDDDSDEENCGC 616
+E +E C F+C CV +CDG+ DC D SDEE+C C
Sbjct: 522 EEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDC 568
Score = 41.2 bits (95), Expect = 0.005
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 5/69 (7%)
Query: 389 NGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNS 448
NG C+P+ CDG +DC +G DE NC T + D C+ P + C G C +
Sbjct: 467 NGLCVPA---CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKV--CDGQPDCLNGSD 521
Query: 449 LNNCSQCEP 457
C + P
Sbjct: 522 EEQCQEGVP 530
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 186 bits (472), Expect = 1e-46
Identities = 127/371 (34%), Positives = 186/371 (50%), Gaps = 35/371 (9%)
Query: 680 CSDSSDEWDCV-----TLSINVNSSSFLMVHRAATEHH---VCADGWQEILSQLACKQMG 731
CS++S E + T+S +NS FL+ + + VC +GW L C +G
Sbjct: 93 CSEASAEEALLPALPKTVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLG 152
Query: 732 LGEPSVTKLIQEQEKEPRWLTLHSNWESLN-----GTTLHELLVNGQSCESRSKISLLCT 786
+L + + L+S+ E G L E +C S +SL C+
Sbjct: 153 H-----LRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS 207
Query: 787 KQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFE 846
+CG RP A RI+GG++ PGRWPWQ S+ + H CG ++A +WV+T AHC
Sbjct: 208 --ECGARPLA---SRIVGGQSVAPGRWPWQASV-ALGFRHTCGGSVLAPRWVVTAAHCMH 261
Query: 847 GRENAAV--WKVVLGINNLDHPSVFM-QTRFVKTIILHPRYSRAVVDYDISIVELSEDIS 903
A + W+V G+ + H +V Q V+ II HP YS DYD++++ L ++
Sbjct: 262 SFRLARLSSWRVHAGL--VSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALN 319
Query: 904 ETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFK---LQEGEVRIISLEHCQSYFD 960
+ V VCLP EQ + C+++GWGH + LQ+ V + S + C S
Sbjct: 320 FSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCV 379
Query: 961 MK-TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGV 1019
+T RM+CAGY G D+C GDSGGPLVC G W L G+ SWG C ++ PGV
Sbjct: 380 YSGALTPRMLCAGYLDGRADACQGDSGGPLVC-PDGDTWRLVGVVSWGRGC-AEPNHPGV 437
Query: 1020 YSNVSYFVEWI 1030
Y+ V+ F++WI
Sbjct: 438 YAKVAEFLDWI 448
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 181 bits (459), Expect = 3e-45
Identities = 106/261 (40%), Positives = 144/261 (55%), Gaps = 22/261 (8%)
Query: 789 DCGR-RPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEG 847
DCGR P+AR I+GG ++PG WPWQ SL GHICG LIA WVL+ AHCF
Sbjct: 37 DCGRPEPSAR----IVGGSNAQPGTWPWQVSLH-HGGGHICGGSLIAPSWVLSAAHCFMT 91
Query: 848 R---ENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISE 904
E AA W V+LG+++ D P TR V I++ YS+ + D++++ L+ S
Sbjct: 92 NGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASL 151
Query: 905 TGYVRPVCLPNPEQWLEPDTYCYITGWGHMGN----KMPFKLQEGEVRIISLEHCQSYFD 960
V PVCLP T C+ TGWG + +P+ LQE E+R++ CQ +
Sbjct: 152 GPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYS 211
Query: 961 MK-------TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSK 1013
I M+CAGY G D+C GDSGGPLVCE+ GGRW G+TS+G C +
Sbjct: 212 QPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEE-GGRWFQAGITSFGFGC-GR 269
Query: 1014 VLGPGVYSNVSYFVEWIKRQI 1034
PGV++ V+ + WI+ Q+
Sbjct: 270 RNRPGVFTAVATYEAWIREQV 290
Score = 75.1 bits (183), Expect = 3e-13
Identities = 61/220 (27%), Positives = 95/220 (43%), Gaps = 25/220 (11%)
Query: 805 GRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAA-------VWKVV 857
G+ RPG WPW+ + P C L+++ WVL A CF ++ W+V+
Sbjct: 326 GKAPRPGAWPWEAQVMV-PGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL 384
Query: 858 LGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPE 917
L PS R V ++ H S D+++++L ++ + RPVCLP+PE
Sbjct: 385 L-------PSRPRAER-VARLVQHENASWDNAS-DLALLQLRTPVNLSAASRPVCLPHPE 435
Query: 918 QWLEPDTYCYITGWGHMGNKM-PFKLQEGEVRIISLEHC-----QSYFDMKTITTRMICA 971
+ P + C + WG + P L E E+ HC + + +C
Sbjct: 436 HYFLPGSRCRLARWGRGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCP 495
Query: 972 GY-ESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVC 1010
Y E V SC DS L+C++ G W L G+ + S C
Sbjct: 496 AYQEKEEVGSCWNDSRWSLLCQEE-GTWFLAGIRDFPSGC 534
Score = 62.4 bits (150), Expect = 2e-09
Identities = 50/208 (24%), Positives = 81/208 (38%), Gaps = 13/208 (6%)
Query: 813 WPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCF--EGRENAAVWKVVLGINNLDH-PSVF 869
WPW + +C +L+A WVL HC G +V LG P
Sbjct: 601 WPWLAEVHVA-GDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGH 659
Query: 870 MQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYIT 929
+R V +I L + ++++ELS + + P+CL + P C++
Sbjct: 660 QVSRLVISIRLPQHLG---LRPPLALLELSSRVEPSPSALPICLH--PAGIPPGASCWVL 714
Query: 930 GWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPL 989
GW +++P V I++ C + + +C Y G + C S PL
Sbjct: 715 GWKEPQDRVPVA---AAVSILTQRICDCLYQ-GILPPGTLCVLYAEGQENRCEMTSAPPL 770
Query: 990 VCEKPGGRWTLFGLTSWGSVCFSKVLGP 1017
+C+ G W L G+ GS +GP
Sbjct: 771 LCQMTEGSWILVGMAVQGSRELFAAIGP 798
>gi|4503627 coagulation factor XI precursor [Homo sapiens]
Length = 625
Score = 179 bits (454), Expect = 1e-44
Identities = 96/240 (40%), Positives = 140/240 (58%), Gaps = 10/240 (4%)
Query: 797 RMNKRILGGRTSRPGRWPWQCSLQ--SEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVW 854
++ RI+GG S G WPWQ +L S H+CG +I +W+LT AHCF G E+ +
Sbjct: 383 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL 442
Query: 855 KVVLGINNLDHPSVFMQTRF--VKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVC 912
+V GI L+ + T F V+ II+H +Y A YDI++++L ++ T RP+C
Sbjct: 443 RVYSGI--LNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPIC 500
Query: 913 LPNPEQWLEPDTYCYITGWGH--MGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMIC 970
LP+ T C++TGWG+ + +K+ LQ+ ++ +++ E CQ + IT +MIC
Sbjct: 501 LPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMIC 560
Query: 971 AGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWI 1030
AGY G D+C GDSGGPL C K W L G+TSWG C + PGVY+NV +V+WI
Sbjct: 561 AGYREGGKDACKGDSGGPLSC-KHNEVWHLVGITSWGEGCAQRE-RPGVYTNVVEYVDWI 618
>gi|4506143 neurotrypsin precursor [Homo sapiens]
Length = 875
Score = 179 bits (453), Expect = 2e-44
Identities = 132/434 (30%), Positives = 200/434 (46%), Gaps = 56/434 (12%)
Query: 644 PDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSD---------EWDCVTLSI 694
P ++D+ +CS + L+C SR W G DCS D E ++L
Sbjct: 447 PIWLDDVSCSGKETRFLQC------SRRQW--GRHDCSHREDVSIACYPGGEGHRLSLGF 498
Query: 695 NVNSSSFLMVHRAATEHHV-------CADGWQEILSQLACKQMGLGEPSVTKLIQEQEKE 747
V E + C DGW + + + C+Q+G P+ + + +
Sbjct: 499 PVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEG 558
Query: 748 PRWLTLHSNWESLNGTTLHELL---VNGQSCESRSKISLLCT---------------KQD 789
+ + + + N +L + + + +C ++C
Sbjct: 559 KGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSV 618
Query: 790 CGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGH----ICGCVLIAKKWVLTVAHCF 845
CG R R KRI+GG+ S G WPWQ SL+ + S +CG L++ WVLT AHCF
Sbjct: 619 CGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF 678
Query: 846 EGRENAA-VWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISE 904
+ N+ + V +G + P F + V+ I++H Y DYDI++V L +
Sbjct: 679 KRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQ 738
Query: 905 ----TGYVRPVCLPN-PEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYF 959
+ +V P CLP E+ + + CYITGWG G LQ+ + ++ C+ +
Sbjct: 739 CARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERY 798
Query: 960 DMKTITTRMICAG--YESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGP 1017
+ T RM+CAG +E VDSC GDSGGPL+CE+PG W ++G+TSWG C K P
Sbjct: 799 KGR-FTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKD-SP 856
Query: 1018 GVYSNVSYFVEWIK 1031
GVY+ VS FV WIK
Sbjct: 857 GVYTKVSAFVPWIK 870
Score = 34.7 bits (78), Expect = 0.48
Identities = 24/103 (23%), Positives = 41/103 (39%), Gaps = 4/103 (3%)
Query: 713 VCADGWQEILSQLACKQMGL--GEPSVTKLIQEQEKEPRWL-TLHSNWESLNGTTLHELL 769
VC DGW E+ + + C+Q+G G+ + E+ P WL + + +
Sbjct: 411 VCDDGWTELNTYVVCRQLGFKYGKQASANHF-EESTGPIWLDDVSCSGKETRFLQCSRRQ 469
Query: 770 VNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGR 812
C R +S+ C G R + R++ G + GR
Sbjct: 470 WGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGR 512
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 177 bits (450), Expect = 4e-44
Identities = 145/510 (28%), Positives = 215/510 (42%), Gaps = 108/510 (21%)
Query: 255 ICFSPQQEN----GKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCS 307
+C++P++ G++ C + F C +G CI +C+G DC D SDE +C C+
Sbjct: 15 LCWAPRESGATGTGRKAKCEPSQ-FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA 73
Query: 308 ENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT----EHRCG--DGRCIAMEWV 361
E+ F C+ G+C+ CDG DC D SDE C+ T E CG +CI + W
Sbjct: 74 ESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWR 133
Query: 362 CDGDHDCVDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQ 418
CDG++DC DE NC +C S C +G+CI F C+G +DC DGSDE +C+
Sbjct: 134 CDGENDCDSGEDEENCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA--P 190
Query: 419 TSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFG 478
+C + +C + C+ S +CD + +CS +LE C P
Sbjct: 191 PTCGAHEFQCSTSSCIPI---SWVCDDD---ADCSDQSDESLEQCGRQP----------- 233
Query: 479 HRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKE 538
++ T C P ++ G C H K
Sbjct: 234 ------------------VIHTKC-------------PASEIQCGS------GECIHKKW 256
Query: 539 RCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRR 598
RC+ D DC ++ SD C C P F+C G C+ SR+
Sbjct: 257 RCDG-----------DPDC----KDGSDEVNCPS-----RTCRPDQFECEDGSCIHGSRQ 296
Query: 599 CDGQADCDDDSDEENC----GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF 654
C+G DC D SDE NC C ++C S +C+ + +C+ DC D+ DE
Sbjct: 297 CNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVCNQEQDCRDWSDEP-LKE 354
Query: 655 CQDDELECANHAC--VSRDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRA 707
C +E N C + +DL E DC+ + D T N S + ++
Sbjct: 355 CHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLK 414
Query: 708 ATEHHVCADGWQEILSQLACKQMGLGEPSV 737
C+ G+Q L+ CK +G EPS+
Sbjct: 415 GGYKCECSRGYQMDLATGVCKAVG-KEPSL 443
Score = 108 bits (269), Expect = 3e-23
Identities = 108/434 (24%), Positives = 164/434 (37%), Gaps = 119/434 (27%)
Query: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDP 445
+C NG+CI ++CDGDEDC DGSD ++ C+ C +S
Sbjct: 39 QCTNGRCITLLWKCDGDEDCVDGSD--------------EKNCVKKTCAES--------- 75
Query: 446 NNSLNNCSQCEPITLELCMNLPY---NSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502
+ + N QC P + C P S P RT
Sbjct: 76 -DFVCNNGQCVPSRWK-CDGDPDCEDGSDESPEQCHMRT--------------------- 112
Query: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDC-SQFP 561
C I C ++ + IP RC+ + DC S
Sbjct: 113 --------CRIHEISCGAHSTQCIPV--------SWRCDG-----------ENDCDSGED 145
Query: 562 EENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG---CKE 618
EEN N TC SP F C SG+C+ + C+GQ DC D SDE +C C
Sbjct: 146 EENCGNITC----------SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGA 195
Query: 619 RDLWECPSNKQCLKHTVICDGFPDCPDYMDE--KNC-------SFCQDDELECANHACVS 669
+ ++C S C+ + +CD DC D DE + C + C E++C + C+
Sbjct: 196 HE-FQC-STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
Query: 670 RDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRAATEHHVCADGWQEILSQ 724
+ CDG+ DC D SDE +C + + S + R C DG E+ +
Sbjct: 254 KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
Query: 725 LACKQMGLGE--------PSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCE 776
+ +G G+ ++K+ +++ W + E L ++E LVN C
Sbjct: 314 NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDW-----SDEPLKECHINECLVNNGGCS 368
Query: 777 SRSKISLLCTKQDC 790
K ++ + DC
Sbjct: 369 HICKDLVIGYECDC 382
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 177 bits (450), Expect = 4e-44
Identities = 145/510 (28%), Positives = 215/510 (42%), Gaps = 108/510 (21%)
Query: 255 ICFSPQQEN----GKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCS 307
+C++P++ G++ C + F C +G CI +C+G DC D SDE +C C+
Sbjct: 15 LCWAPRESGATGTGRKAKCEPSQ-FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA 73
Query: 308 ENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT----EHRCG--DGRCIAMEWV 361
E+ F C+ G+C+ CDG DC D SDE C+ T E CG +CI + W
Sbjct: 74 ESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWR 133
Query: 362 CDGDHDCVDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQ 418
CDG++DC DE NC +C S C +G+CI F C+G +DC DGSDE +C+
Sbjct: 134 CDGENDCDSGEDEENCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA--P 190
Query: 419 TSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFG 478
+C + +C + C+ S +CD + +CS +LE C P
Sbjct: 191 PTCGAHEFQCSTSSCIPI---SWVCDDD---ADCSDQSDESLEQCGRQP----------- 233
Query: 479 HRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKE 538
++ T C P ++ G C H K
Sbjct: 234 ------------------VIHTKC-------------PASEIQCGS------GECIHKKW 256
Query: 539 RCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRR 598
RC+ D DC ++ SD C C P F+C G C+ SR+
Sbjct: 257 RCDG-----------DPDC----KDGSDEVNCPS-----RTCRPDQFECEDGSCIHGSRQ 296
Query: 599 CDGQADCDDDSDEENC----GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF 654
C+G DC D SDE NC C ++C S +C+ + +C+ DC D+ DE
Sbjct: 297 CNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVCNQEQDCRDWSDEP-LKE 354
Query: 655 CQDDELECANHAC--VSRDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRA 707
C +E N C + +DL E DC+ + D T N S + ++
Sbjct: 355 CHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLK 414
Query: 708 ATEHHVCADGWQEILSQLACKQMGLGEPSV 737
C+ G+Q L+ CK +G EPS+
Sbjct: 415 GGYKCECSRGYQMDLATGVCKAVG-KEPSL 443
Score = 108 bits (269), Expect = 3e-23
Identities = 108/434 (24%), Positives = 164/434 (37%), Gaps = 119/434 (27%)
Query: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDP 445
+C NG+CI ++CDGDEDC DGSD ++ C+ C +S
Sbjct: 39 QCTNGRCITLLWKCDGDEDCVDGSD--------------EKNCVKKTCAES--------- 75
Query: 446 NNSLNNCSQCEPITLELCMNLPY---NSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502
+ + N QC P + C P S P RT
Sbjct: 76 -DFVCNNGQCVPSRWK-CDGDPDCEDGSDESPEQCHMRT--------------------- 112
Query: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDC-SQFP 561
C I C ++ + IP RC+ + DC S
Sbjct: 113 --------CRIHEISCGAHSTQCIPV--------SWRCDG-----------ENDCDSGED 145
Query: 562 EENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG---CKE 618
EEN N TC SP F C SG+C+ + C+GQ DC D SDE +C C
Sbjct: 146 EENCGNITC----------SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGA 195
Query: 619 RDLWECPSNKQCLKHTVICDGFPDCPDYMDE--KNC-------SFCQDDELECANHACVS 669
+ ++C S C+ + +CD DC D DE + C + C E++C + C+
Sbjct: 196 HE-FQC-STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
Query: 670 RDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRAATEHHVCADGWQEILSQ 724
+ CDG+ DC D SDE +C + + S + R C DG E+ +
Sbjct: 254 KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
Query: 725 LACKQMGLGE--------PSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCE 776
+ +G G+ ++K+ +++ W + E L ++E LVN C
Sbjct: 314 NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDW-----SDEPLKECHINECLVNNGGCS 368
Query: 777 SRSKISLLCTKQDC 790
K ++ + DC
Sbjct: 369 HICKDLVIGYECDC 382
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 177 bits (449), Expect = 5e-44
Identities = 143/454 (31%), Positives = 193/454 (42%), Gaps = 95/454 (20%)
Query: 269 CGRGENFLCASGI-----CIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHTGKCLN 320
CGR +F CA CIP + QC+G NDC D SDE C CS FHC GKC+
Sbjct: 27 CGRS-HFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIR 85
Query: 321 YSLVCDGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
S VCDG +DC D SDEQ+C +C E C +G CI W CDGD+DC D SDE C
Sbjct: 86 RSWVCDGDNDCEDDSDEQDCPPRECE-EDEFPCQNGYCIRSLWHCDGDNDCGDNSDE-QC 143
Query: 378 SCH--SQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENC--SVIQTSCQEGDQRCLYNPC 433
S C +G CI + CDGD DCKDGSDEENC +V C + +C Y C
Sbjct: 144 DMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRC 203
Query: 434 ---LDSCGGSSLCDPNNSLNNCSQCEP-------ITLELCMNLPYNSTSYPNYFGHRTQK 483
+ C G C + ++CS +P LC+N G R
Sbjct: 204 ILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA-----------GWRCDG 252
Query: 484 EASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESV 543
+A +S + NC ++C + RC S
Sbjct: 253 DADCDDQSD------ERNC--------------------------TTSMCTAEQFRCHSG 280
Query: 544 LGIVGLQWPED--TDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDG 601
V L W D DC+ +NSD + C + +C+ F C +G+C+ + C+G
Sbjct: 281 -RCVRLSWRCDGEDDCA----DNSDEENC--ENTGSPQCALDQFLCWNGRCIGQRKLCNG 333
Query: 602 QADCDDDSDE---ENCGCKERDLWECPSNKQCLKHTVICDGFPDC---PDYMDEKNCSFC 655
DC D+SDE +NC + + +N C + + G C Y ++ C
Sbjct: 334 VNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
Query: 656 QDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
QD ECA S+ C++S + C
Sbjct: 394 QDVN-ECAEEGYCSQ--------GCTNSEGAFQC 418
Score = 155 bits (391), Expect = 2e-37
Identities = 87/213 (40%), Positives = 111/213 (52%), Gaps = 18/213 (8%)
Query: 256 CFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFH 312
C E+G L +F C +G CI C+G NDC+D SDE C C E+ F
Sbjct: 57 CGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP 116
Query: 313 CHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT--EHRCGDGRCIAMEWVCDGDHDCVD 370
C G C+ CDG +DCGD SDEQ CD + E RC DG CIA W CDGD DC D
Sbjct: 117 CQNGYCIRSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKD 175
Query: 371 KSDEVNC-------SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE 423
SDE NC C+ + +C G+CI + CDGD+DC D SDE +CS Q C+
Sbjct: 176 GSDEENCPSAVPAPPCNLEEF-QCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQ-PCRS 233
Query: 424 GDQRCLYNPCLDS---CGGSSLCDPNNSLNNCS 453
G+ C C+++ C G + CD + NC+
Sbjct: 234 GEFMCDSGLCINAGWRCDGDADCDDQSDERNCT 266
Score = 122 bits (306), Expect = 2e-27
Identities = 103/366 (28%), Positives = 147/366 (40%), Gaps = 66/366 (18%)
Query: 350 CGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGS 409
C G + E C H +C L EC CIP+ +QCDGD DC D S
Sbjct: 15 CAHGLASSPECACGRSH----------FTCAVSALGECT---CIPAQWQCDGDNDCGDHS 61
Query: 410 DEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNC--SQCE----PITL 460
DE+ C I +C D C C+ C G + C+ ++ +C +CE P
Sbjct: 62 DEDGC--ILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQN 119
Query: 461 ELCMNLPYNSTSYPNYFGHRTQKEASI------SWESSLFPALVQ-------TNCYKYLM 507
C+ ++ N G + ++ + + S + + T+C
Sbjct: 120 GYCIRSLWHCDG-DNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSD 178
Query: 508 FFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDN 567
+C VP PPC L E +L I D DC + +E+ +
Sbjct: 179 EENCPSAVP---------APPCN-LEEFQCAYGRCILDI--YHCDGDDDCGDWSDESDCS 226
Query: 568 QTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK--ERDLWECP 625
+ C F C SG C+ A RCDG ADCDD SDE NC + + C
Sbjct: 227 SH--------QPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCH 278
Query: 626 SNKQCLKHTVICDGFPDCPDYMDEKNCS-----FCQDDELECANHACVSRDLWCDGEADC 680
S + C++ + CDG DC D DE+NC C D+ C N C+ + C+G DC
Sbjct: 279 SGR-CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDC 337
Query: 681 SDSSDE 686
D+SDE
Sbjct: 338 GDNSDE 343
Score = 110 bits (276), Expect = 5e-24
Identities = 64/171 (37%), Positives = 89/171 (52%), Gaps = 19/171 (11%)
Query: 527 PPCRALCEHSKERCE-SVLG---IVGLQWP--EDTDCSQFPEENSDNQTCLMPDEYVEEC 580
P C C S C S LG + QW D DC ++SD C++P C
Sbjct: 23 PECA--CGRSHFTCAVSALGECTCIPAQWQCDGDNDCG----DHSDEDGCILPT-----C 71
Query: 581 SPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECP-SNKQCLKHTVICDG 639
SP F C +G+C+ S CDG DC+DDSDE++C +E + E P N C++ CDG
Sbjct: 72 SPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDG 131
Query: 640 FPDCPDYMDEK-NCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
DC D DE+ + C D E C++ +C++ +CDG+ DC D SDE +C
Sbjct: 132 DNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
Score = 102 bits (254), Expect = 2e-21
Identities = 64/184 (34%), Positives = 88/184 (47%), Gaps = 22/184 (11%)
Query: 518 CDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPE-DTDCSQFPEENSDNQTCLMPDEY 576
C+ ++ E P R CE + C++ I L + D DC +NSD Q C M
Sbjct: 96 CEDDSDEQDCPPRE-CEEDEFPCQNGYCIRSLWHCDGDNDCG----DNSDEQ-CDM---- 145
Query: 577 VEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK------ERDLWECPSNKQC 630
+CS F+C G C+ CDG DC D SDEENC + ++C + C
Sbjct: 146 -RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGR-C 203
Query: 631 LKHTVICDGFPDCPDYMDEKNCSF---CQDDELECANHACVSRDLWCDGEADCSDSSDEW 687
+ CDG DC D+ DE +CS C+ E C + C++ CDG+ADC D SDE
Sbjct: 204 ILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDER 263
Query: 688 DCVT 691
+C T
Sbjct: 264 NCTT 267
Score = 31.6 bits (70), Expect = 4.1
Identities = 15/41 (36%), Positives = 18/41 (43%), Gaps = 5/41 (12%)
Query: 655 CQDDELECANHA-----CVSRDLWCDGEADCSDSSDEWDCV 690
C CA A C+ CDG+ DC D SDE C+
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCI 67
>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sapiens]
Length = 437
Score = 175 bits (444), Expect = 2e-43
Identities = 125/384 (32%), Positives = 190/384 (49%), Gaps = 46/384 (11%)
Query: 668 VSRDLWCDGEADCSDSSDEWDCV-------TLSINVNSS-SFLMVHRAATEH--HVCADG 717
+ R CDGE DC DE CV +++ ++ S L V +AT + C D
Sbjct: 71 IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130
Query: 718 WQEILSQLACKQMGLGEPSVTKLIQ---EQEKEPRWLTLHSNWESLNGTTLHELLVNGQS 774
+ E L++ AC+QMG + ++ +Q+ + +T +S EL + S
Sbjct: 131 FTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQ----------ELRMRNSS 180
Query: 775 --CESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVL 832
C S S +SL C CG+ + R++GG + WPWQ S+Q + H+CG +
Sbjct: 181 GPCLSGSLVSLHCLA--CGK---SLKTPRVVGGEEASVDSWPWQVSIQYDKQ-HVCGGSI 234
Query: 833 IAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIIL--HPRYSRAVVD 890
+ WVLT AHCF + WKV G + L F K II+ +P Y + D
Sbjct: 235 LDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGS---FPSLAVAKIIIIEFNPMYPK---D 288
Query: 891 YDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM---GNKMPFKLQEGEV 947
DI++++L ++ +G VRP+CLP ++ L P T +I GWG G KM L + V
Sbjct: 289 NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASV 348
Query: 948 RIISLEHCQSYFDMK-TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSW 1006
++I C + + +T +M+CAG G VD+C GDSGGPL+ + +W + G+ SW
Sbjct: 349 QVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSW 406
Query: 1007 GSVCFSKVLGPGVYSNVSYFVEWI 1030
G C PGVY+ VS ++ WI
Sbjct: 407 GYGCGGPST-PGVYTKVSAYLNWI 429
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 174 bits (442), Expect = 3e-43
Identities = 95/256 (37%), Positives = 140/256 (54%), Gaps = 18/256 (7%)
Query: 790 CGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRE 849
CG P AR I GG ++ G+WPWQ S+ E H+CG L++++WVL+ AHCF
Sbjct: 37 CGVAPQAR----ITGGSSAVAGQWPWQVSITYE-GVHVCGGSLVSEQWVLSAAHCFPSEH 91
Query: 850 NAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVR 909
+ ++V LG + LD S + +K II HP Y + DI++++LS I+ + Y+R
Sbjct: 92 HKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIR 151
Query: 910 PVCLPNPEQWLEPDTYCYITGWGHMGNKM----PFKLQEGEVRIISLEHCQSYFDMKT-- 963
P+CLP +C +TGWGH+ + P LQ+ EV +IS E C +++
Sbjct: 152 PICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKP 211
Query: 964 -----ITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPG 1018
+ M+CAGY G D+C GDSGGPL C G W L G+ SWG C ++ PG
Sbjct: 212 EEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVE-GLWYLTGIVSWGDACGAR-NRPG 269
Query: 1019 VYSNVSYFVEWIKRQI 1034
VY+ S + WI+ ++
Sbjct: 270 VYTLASSYASWIQSKV 285
>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
sapiens]
Length = 432
Score = 174 bits (441), Expect = 4e-43
Identities = 125/381 (32%), Positives = 189/381 (49%), Gaps = 45/381 (11%)
Query: 668 VSRDLWCDGEADCSDSSDEWDCV-------TLSINVNSS-SFLMVHRAATEH--HVCADG 717
+ R CDGE DC DE CV +++ ++ S L V +AT + C D
Sbjct: 71 IPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDN 130
Query: 718 WQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQS--C 775
+ E L++ AC+QMG ++ +Q+ + +T +S EL + S C
Sbjct: 131 FTEALAETACRQMGYSR--AVEIGPDQDLDVVEITENSQ----------ELRMRNSSGPC 178
Query: 776 ESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAK 835
S S +SL C CG+ + R++GG + WPWQ S+Q + H+CG ++
Sbjct: 179 LSGSLVSLHCLA--CGK---SLKTPRVVGGEEASVDSWPWQVSIQYDKQ-HVCGGSILDP 232
Query: 836 KWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIIL--HPRYSRAVVDYDI 893
WVLT AHCF + WKV G + L F K II+ +P Y + D DI
Sbjct: 233 HWVLTAAHCFRKHTDVFNWKVRAGSDKLGS---FPSLAVAKIIIIEFNPMYPK---DNDI 286
Query: 894 SIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM---GNKMPFKLQEGEVRII 950
++++L ++ +G VRP+CLP ++ L P T +I GWG G KM L + V++I
Sbjct: 287 ALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVI 346
Query: 951 SLEHCQSYFDMK-TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSV 1009
C + + +T +M+CAG G VD+C GDSGGPL+ + +W + G+ SWG
Sbjct: 347 DSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ--SDQWHVVGIVSWGYG 404
Query: 1010 CFSKVLGPGVYSNVSYFVEWI 1030
C PGVY+ VS ++ WI
Sbjct: 405 CGGPST-PGVYTKVSAYLNWI 424
>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
Length = 416
Score = 174 bits (441), Expect = 4e-43
Identities = 103/282 (36%), Positives = 149/282 (52%), Gaps = 22/282 (7%)
Query: 765 LHELLVNGQSC-----------ESRSKISLLCTKQDCGRRPAARM--NKRILGGRTSRPG 811
LH++L N + E S + T CGR+ A + +I+ G++S G
Sbjct: 135 LHQMLKNNMASWNAVPASIKLMEISKAASEMLTNNCCGRQVANSIITGNKIVNGKSSLEG 194
Query: 812 RWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQ 871
WPWQ S+Q + H CG LI+ +W+L+ AHCF + N+ W V GI ++ P +
Sbjct: 195 AWPWQASMQWK-GRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIV-VNKPYM--- 249
Query: 872 TRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGW 931
TR V+ II H YS + DI++V+L+E++S T Y+R +CLP + L + +TGW
Sbjct: 250 TRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGW 309
Query: 932 G--HMGNKMPFKLQEGEVRIISLEHCQ-SYFDMKTITTRMICAGYESGTVDSCMGDSGGP 988
G +M P LQE ++II + C SY +T M+CAG+ SG D+C DSGGP
Sbjct: 310 GTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGP 369
Query: 989 LVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWI 1030
L W L G+ SWG C K PGVY+ V+ + WI
Sbjct: 370 LAYPDSRNIWHLVGIVSWGDGC-GKKNKPGVYTRVTSYRNWI 410
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 174 bits (440), Expect = 5e-43
Identities = 99/257 (38%), Positives = 133/257 (51%), Gaps = 18/257 (7%)
Query: 790 CGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRE 849
CGR RM R++GG+ ++ G WPWQ S+Q S H CG LIA++WVLT AHCF
Sbjct: 26 CGR---PRMLNRMVGGQDTQEGEWPWQVSIQRNGS-HFCGGSLIAEQWVLTAAHCFRNTS 81
Query: 850 NAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVR 909
++++V+LG L P V+ + +P Y D+++VEL + T Y+
Sbjct: 82 ETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYIL 141
Query: 910 PVCLPNPEQWLEPDTYCYITGWGHMGNK----MPFKLQEGEVRIISLEHCQSYFDM---- 961
PVCLP+P E C++TGWG + P LQ+ V II C +
Sbjct: 142 PVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEF 201
Query: 962 ----KTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGP 1017
KTI M+CAG+E G D+C GDSGGPLVC G W G+ SWG C ++ P
Sbjct: 202 GYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVC-LVGQSWLQAGVISWGEGC-ARQNRP 259
Query: 1018 GVYSNVSYFVEWIKRQI 1034
GVY V+ WI R I
Sbjct: 260 GVYIRVTAHHNWIHRII 276
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 173 bits (438), Expect = 9e-43
Identities = 121/388 (31%), Positives = 184/388 (47%), Gaps = 40/388 (10%)
Query: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVC 714
C C++ CV + CDG DC D SDE CV+ N+SSF +
Sbjct: 358 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQ------HGPLI 411
Query: 715 ADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQS 774
DG+++ + G E + T+ I + ++ N +
Sbjct: 412 CDGFRDC-------ENGRDEQNCTQSIPCNNR---------TFKCGNDICFRK---QNAK 452
Query: 775 CESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIA 834
C+ ++ C ++ RI+GG + G WPWQ SL S + CG +I+
Sbjct: 453 CDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAY-CGASVIS 511
Query: 835 KKWVLTVAHCFEGRE--NAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYD 892
++W+L+ AHCF G + W LG+ + + F+ V+ I++H Y+ DYD
Sbjct: 512 REWLLSAAHCFHGNRLSDPTPWTAHLGMY-VQGNAKFVSP--VRRIVVHEYYNSQTFDYD 568
Query: 893 ISIVELSEDISET--GYVRPVCLPNPEQWLEPDTYCYITGWGHM---GNKMPFKLQEGEV 947
I++++LS ET ++P+C+P Q + C++TGWG NK LQ+ EV
Sbjct: 569 IALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEV 628
Query: 948 RIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVC-EKPGGRWTLFGLTSW 1006
+I C S + + IT+RM+CAG SG D+C GDSGGPL C K G+W L G+ SW
Sbjct: 629 ELIDQTLCVSTYGI--ITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSW 686
Query: 1007 GSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034
G + PGVY+ VS FV WI + +
Sbjct: 687 GHGS-GRPNFPGVYTRVSNFVPWIHKYV 713
Score = 86.3 bits (212), Expect = 1e-16
Identities = 46/112 (41%), Positives = 62/112 (55%), Gaps = 9/112 (8%)
Query: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYS-LVCDGYDDCG 332
+F C+SG+C+P +C+G NDC D SDE C + C+T + L+CDG+ DC
Sbjct: 362 SFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPA--CNTSSFRQHGPLICDGFRDCE 419
Query: 333 DLSDEQNC----DCNPTTEHRCGDGRCIAMEWV-CDGDHDCVDKSDEVNCSC 379
+ DEQNC CN T +CG+ C + CDG DC D SDE C+C
Sbjct: 420 NGRDEQNCTQSIPCNNRT-FKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTC 470
Score = 84.7 bits (208), Expect = 4e-16
Identities = 50/145 (34%), Positives = 67/145 (46%), Gaps = 13/145 (8%)
Query: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVIC 637
+ C F+C SG CV ++RCDG DC D+SDE C + C ++ +IC
Sbjct: 356 QPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQP---ACNTSSFRQHGPLIC 412
Query: 638 DGFPDCPDYMDEKNCSF---CQDDELECANHACV-SRDLWCDGEADCSDSSDEWDCVTLS 693
DGF DC + DE+NC+ C + +C N C ++ CDG DC D SDE C
Sbjct: 413 DGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTC-- 470
Query: 694 INVNSSSFLMVHRAATEHHVCADGW 718
S S +HR GW
Sbjct: 471 ----SRSSSALHRIIGGTDTLEGGW 491
Score = 74.3 bits (181), Expect = 5e-13
Identities = 44/125 (35%), Positives = 62/125 (49%), Gaps = 18/125 (14%)
Query: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC-----DCNPTTEHRCGDGRCIAMEW 360
C F C +G C+ + CDG +DC D SDE C CN ++ + G
Sbjct: 358 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHG-------PL 410
Query: 361 VCDGDHDCVDKSDEVNCS----CHSQGLVECRNGQCI-PSTFQCDGDEDCKDGSDEENCS 415
+CDG DC + DE NC+ C+++ +C N C +CDG DC DGSDEE C+
Sbjct: 411 ICDGFRDCENGRDEQNCTQSIPCNNR-TFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCT 469
Query: 416 VIQTS 420
++S
Sbjct: 470 CSRSS 474
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 20/131 (15%)
Query: 332 GDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC-----SCHSQGLVE 386
G + Q C P RC G C+ CDG +DC D+SDE+ C +C++ +
Sbjct: 350 GSYNISQPC---PVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQ 406
Query: 387 CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCL----DSCGGSSL 442
+G I CDG DC++G DE+NC+ C +C + C C G+
Sbjct: 407 --HGPLI-----CDGFRDCENGRDEQNCTQ-SIPCNNRTFKCGNDICFRKQNAKCDGTVD 458
Query: 443 CDPNNSLNNCS 453
C + C+
Sbjct: 459 CPDGSDEEGCT 469
Score = 48.1 bits (113), Expect = 4e-05
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSL 442
G C +G C+P +CDG DC D SDE C Q +C R + P + C G
Sbjct: 361 GSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFR-QHGPLI--CDGFRD 417
Query: 443 CDPNNSLNNCSQCEP 457
C+ NC+Q P
Sbjct: 418 CENGRDEQNCTQSIP 432
Score = 35.8 bits (81), Expect = 0.22
Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Query: 261 QENGKQLLCGRGENFLCASGICIPGK-LQCNGYNDCDDWSDEAHCNCSENLFHCH 314
++N Q + F C + IC + +C+G DC D SDE C CS + H
Sbjct: 424 EQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALH 478
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 171 bits (432), Expect = 4e-42
Identities = 96/251 (38%), Positives = 138/251 (54%), Gaps = 13/251 (5%)
Query: 789 DCGRRP--AARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFE 846
+CG P +RILGG + G WPWQ SL+ + H CG LI W+LT AHCF
Sbjct: 172 ECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLN-NAHHCGGSLINNMWILTAAHCFR 230
Query: 847 GRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETG 906
N W GI+ P + M+ V+ I++H Y A + DI++V L ++ T
Sbjct: 231 SNSNPRDWIATSGISTT-FPKLRMR---VRNILIHNNYKSATHENDIALVRLENSVTFTK 286
Query: 907 YVRPVCLPNPEQWLEPDTYCYITGWG---HMGNKMPFKLQEGEVRIISLEHCQSYFDMK- 962
+ VCLP Q + P + Y+TGWG + G+ +P +L++G+VRIIS + C +
Sbjct: 287 DIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVP-ELRQGQVRIISNDVCNAPHSYNG 345
Query: 963 TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSN 1022
I + M+CAG G VD+C GDSGGPLV E W + G+ SWG C PGVY+
Sbjct: 346 AILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQC-GLPDKPGVYTR 404
Query: 1023 VSYFVEWIKRQ 1033
V+ +++WI++Q
Sbjct: 405 VTAYLDWIRQQ 415
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 167 bits (424), Expect = 4e-41
Identities = 100/281 (35%), Positives = 144/281 (51%), Gaps = 19/281 (6%)
Query: 770 VNGQSCESRSKISLLCTKQDCGRRPAA----RMNKRILGGRTSRPGRWPWQCSLQSEPSG 825
+ G SC + +L GR+ AA RM+ RI+GGR R G WPWQ S+Q
Sbjct: 1 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHR-GA 59
Query: 826 HICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYS 885
H+CG LIA +WVLT AHCF R A ++V LG L S + V+ ++L P YS
Sbjct: 60 HVCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYS 119
Query: 886 RAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPF----K 941
D+++++L + + V+PVCLP P P T C +TGWG + +P
Sbjct: 120 EDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRP 179
Query: 942 LQEGEVRIISLEHCQSYFDM--------KTITTRMICAGYESGTVDSCMGDSGGPLVCEK 993
LQ V ++ C + + + + +CAGY G D+C GDSGGPL C +
Sbjct: 180 LQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQ 239
Query: 994 PGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034
G W L G+ SWG C + PGVY++V+ + WI+ ++
Sbjct: 240 -SGSWVLVGVVSWGKGC-ALPNRPGVYTSVATYSPWIQARV 278
>gi|21614531 testisin isoform 2 [Homo sapiens]
Length = 312
Score = 164 bits (415), Expect = 4e-40
Identities = 101/257 (39%), Positives = 136/257 (52%), Gaps = 22/257 (8%)
Query: 790 CGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFE-GR 848
CGRR + RI+GG + GRWPWQ SL+ S H+CG L++ +W LT AHCFE
Sbjct: 33 CGRRV---ITSRIVGGEDAELGRWPWQGSLRLWDS-HVCGVSLLSHRWALTAAHCFETDL 88
Query: 849 ENAAVWKVVLGINNLDHPS-----VFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDIS 903
+ + W V G PS + FV I L PRY YDI++V+LS ++
Sbjct: 89 SDPSGWMVQFG-QLTSMPSFWSLQAYYTRYFVSNIYLSPRYL-GNSPYDIALVKLSAPVT 146
Query: 904 ETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGN----KMPFKLQEGEVRIISLEHCQ--- 956
T +++P+CL E T C++TGWG++ P LQE +V II+ C
Sbjct: 147 YTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLF 206
Query: 957 -SYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVL 1015
Y K I M+CAG G D+C GDSGGPL C K G W G+ SWG C +
Sbjct: 207 LKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGC-GRPN 264
Query: 1016 GPGVYSNVSYFVEWIKR 1032
PGVY+N+S+ EWI++
Sbjct: 265 RPGVYTNISHHFEWIQK 281
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.455
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,704,473
Number of Sequences: 37866
Number of extensions: 2461987
Number of successful extensions: 9285
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 216
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 5558
Number of HSP's gapped (non-prelim): 1804
length of query: 1042
length of database: 18,247,518
effective HSP length: 112
effective length of query: 930
effective length of database: 14,006,526
effective search space: 13026069180
effective search space used: 13026069180
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.