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Search of human proteins with 29171750
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29171750 peroxisome proliferative activated receptor, delta
isoform 2 [Homo sapiens]
(361 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29171750 peroxisome proliferative activated receptor, delta i... 734 0.0
gi|5453940 peroxisome proliferative activated receptor, delta is... 730 0.0
gi|50348666 peroxisome proliferative activated receptor, alpha [... 442 e-124
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 442 e-124
gi|116284373 peroxisome proliferative activated receptor gamma i... 401 e-112
gi|20336229 peroxisome proliferative activated receptor gamma is... 401 e-112
gi|116284368 peroxisome proliferative activated receptor gamma i... 401 e-112
gi|116284370 peroxisome proliferative activated receptor gamma i... 401 e-112
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 134 1e-31
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 134 1e-31
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 133 2e-31
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 126 3e-29
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 126 3e-29
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 125 4e-29
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 125 4e-29
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 125 4e-29
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 125 6e-29
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 121 8e-28
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 113 2e-25
gi|19743907 RAR-related orphan receptor B [Homo sapiens] 112 4e-25
gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens] 109 4e-24
gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens] 109 4e-24
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 107 2e-23
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 107 2e-23
gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] 107 2e-23
gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] 107 2e-23
gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] 107 2e-23
gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] 107 2e-23
gi|11415052 retinoid X receptor, beta [Homo sapiens] 106 4e-23
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 106 4e-23
>gi|29171750 peroxisome proliferative activated receptor, delta
isoform 2 [Homo sapiens]
Length = 361
Score = 734 bits (1895), Expect = 0.0
Identities = 361/361 (100%), Positives = 361/361 (100%)
Query: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
Sbjct: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
Query: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
Sbjct: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
Query: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
Sbjct: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
Query: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
Sbjct: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
Query: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
Sbjct: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
Query: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGG 360
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGG
Sbjct: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGG 360
Query: 361 E 361
E
Sbjct: 361 E 361
>gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
Length = 441
Score = 730 bits (1884), Expect = 0.0
Identities = 359/359 (100%), Positives = 359/359 (100%)
Query: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
Sbjct: 1 MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM 60
Query: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
Sbjct: 61 GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK 120
Query: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
Sbjct: 121 NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK 180
Query: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
Sbjct: 181 HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE 240
Query: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
Sbjct: 241 ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 300
Query: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG
Sbjct: 301 DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 442 bits (1136), Expect = e-124
Identities = 218/316 (68%), Positives = 262/316 (82%), Gaps = 2/316 (0%)
Query: 45 LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103
LS +SSP S+ + G D + G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 72 LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
Query: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163
+KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +
Sbjct: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
Query: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223
E + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+ PFVIHD+ETL AE
Sbjct: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
Query: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283
K LV K + NG+ KE V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 252 KTLVAKLVANGI-QNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
Query: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343
YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
Query: 344 DDSDLALFIAAIILCG 359
DDSD++LF+AAII CG
Sbjct: 371 DDSDISLFVAAIICCG 386
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 442 bits (1136), Expect = e-124
Identities = 218/316 (68%), Positives = 262/316 (82%), Gaps = 2/316 (0%)
Query: 45 LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103
LS +SSP S+ + G D + G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 72 LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
Query: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163
+KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +
Sbjct: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
Query: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223
E + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+ PFVIHD+ETL AE
Sbjct: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
Query: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283
K LV K + NG+ KE V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 252 KTLVAKLVANGI-QNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
Query: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343
YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
Query: 344 DDSDLALFIAAIILCG 359
DDSD++LF+AAII CG
Sbjct: 371 DDSDISLFVAAIICCG 386
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 401 bits (1030), Expect = e-112
Identities = 193/314 (61%), Positives = 251/314 (79%), Gaps = 4/314 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 83 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 142
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 143 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 201
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 202 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 261
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 262 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 321
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 322 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 381
Query: 346 SDLALFIAAIILCG 359
SDLA+FIA IIL G
Sbjct: 382 SDLAIFIAVIILSG 395
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 401 bits (1030), Expect = e-112
Identities = 193/314 (61%), Positives = 251/314 (79%), Gaps = 4/314 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 111 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 170
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 171 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 229
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 230 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 289
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 290 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 349
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 350 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 409
Query: 346 SDLALFIAAIILCG 359
SDLA+FIA IIL G
Sbjct: 410 SDLAIFIAVIILSG 423
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 401 bits (1030), Expect = e-112
Identities = 193/314 (61%), Positives = 251/314 (79%), Gaps = 4/314 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 83 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 142
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 143 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 201
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 202 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 261
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 262 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 321
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 322 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 381
Query: 346 SDLALFIAAIILCG 359
SDLA+FIA IIL G
Sbjct: 382 SDLAIFIAVIILSG 395
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 401 bits (1030), Expect = e-112
Identities = 193/314 (61%), Positives = 251/314 (79%), Gaps = 4/314 (1%)
Query: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 83 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 142
Query: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 143 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 201
Query: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 202 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 261
Query: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 262 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 321
Query: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 322 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 381
Query: 346 SDLALFIAAIILCG 359
SDLA+FIA IIL G
Sbjct: 382 SDLAIFIAVIILSG 395
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 134 bits (338), Expect = 1e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 88 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 134
Score = 62.0 bits (149), Expect = 8e-10
Identities = 38/102 (37%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSG-FVTRE 315
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397
Query: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIIL 357
L S+ D++ FEF+ K NAL+L D +++LF A +++
Sbjct: 398 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLV 437
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 134 bits (338), Expect = 1e-31
Identities = 59/113 (52%), Positives = 83/113 (73%), Gaps = 8/113 (7%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
C+VCGD ASGFHYGVHACEGCKGFFRR+I+ ++Y+KC +C I + NRN+CQ CRF+
Sbjct: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYN 184
KCL++GMS +A+RFGR+P+ EK++++ + + + N Q FS H+ N
Sbjct: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQN 209
Score = 62.0 bits (149), Expect = 8e-10
Identities = 38/102 (37%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSG-FVTRE 315
V+E+ EFAK IP F L +DQV LLK G E + AS+ + V SG + +
Sbjct: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472
Query: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIIL 357
L S+ D++ FEF+ K NAL+L D +++LF A +++
Sbjct: 473 DLHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLV 512
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 133 bits (335), Expect = 2e-31
Identities = 64/144 (44%), Positives = 94/144 (65%), Gaps = 18/144 (12%)
Query: 30 NGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGAS-------------CGSLNMECRV 76
+G P + SSS + + SPP LQ+ + +S + + C+V
Sbjct: 78 DGSPSSSSSSSSSSSSFYNGSPPG---SLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKV 134
Query: 77 CGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQKCL 134
CGD ASGFHYGVHACEGCKGFFRR+I+ ++Y++C +C I + NRN+CQ CRF+KCL
Sbjct: 135 CGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCL 194
Query: 135 ALGMSHNAIRFGRMPEAEKRKLVA 158
++GMS +A+RFGR+P+ EK++++A
Sbjct: 195 SVGMSRDAVRFGRIPKREKQRMLA 218
Score = 62.0 bits (149), Expect = 8e-10
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 257 VRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN-KDGLLVANGSGFVTRE 315
VRE+ EFAK IP F L +DQVTLLK G E + AS+ N KD ++ + +
Sbjct: 447 VREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQ 506
Query: 316 FLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIIL 357
L ++ D++ F+F+ K N+L L + +L LF A +++
Sbjct: 507 ELGAM--GMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLV 546
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 126 bits (316), Expect = 3e-29
Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 44/290 (15%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C VC DK+SG+HYGV +CEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR Q
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQ 137
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFN 191
KC +GMS A+R R +K+K V + + + +PQ+ +L + A+ + F
Sbjct: 138 KCFEVGMSKEAVRNDR---NKKKKEVKEEGSPDSYELSPQLEEL---ITKVSKAHQETFP 191
Query: 192 MTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQC 251
+ + A H Q + GL W + + E++
Sbjct: 192 SLCQLGKYTTNSSADHRV-----------QLDLGL-WDK-------FSELA--------- 223
Query: 252 TTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGS 309
+ + ++ EFAK +P F+ L + DQ+TLLK + + + + +D + ++G
Sbjct: 224 --TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGL 281
Query: 310 GFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
+ + P +D++ F FA + LE+DD++ L A ++CG
Sbjct: 282 TLNRTQMHNAGFGPLTDLV---FAFAGQLLPLEMDDTETGLLSAICLICG 328
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 126 bits (316), Expect = 3e-29
Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 44/290 (15%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C VC DK+SG+HYGV +CEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR Q
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQ 148
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFN 191
KC +GMS A+R R +K+K V + + + +PQ+ +L + A+ + F
Sbjct: 149 KCFEVGMSKEAVRNDR---NKKKKEVKEEGSPDSYELSPQLEEL---ITKVSKAHQETFP 202
Query: 192 MTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQC 251
+ + A H Q + GL W + + E++
Sbjct: 203 SLCQLGKYTTNSSADHRV-----------QLDLGL-WDK-------FSELA--------- 234
Query: 252 TTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGS 309
+ + ++ EFAK +P F+ L + DQ+TLLK + + + + +D + ++G
Sbjct: 235 --TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGL 292
Query: 310 GFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
+ + P +D++ F FA + LE+DD++ L A ++CG
Sbjct: 293 TLNRTQMHNAGFGPLTDLV---FAFAGQLLPLEMDDTETGLLSAICLICG 339
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 125 bits (315), Expect = 4e-29
Identities = 101/336 (30%), Positives = 156/336 (46%), Gaps = 53/336 (15%)
Query: 34 QHALPSSSYTDLS------RSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYG 87
QH LP S Y+ S +SSS ++ + C VC DK+SG+HYG
Sbjct: 45 QHQLPVSGYSTPSPATIETQSSSSEEIVPSPP---SPPPLPRIYKPCFVCQDKSSGYHYG 101
Query: 88 VHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQKCLALGMSHNAIRF 145
V ACEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR QKC +GMS ++R
Sbjct: 102 VSACEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRN 160
Query: 146 GRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKA 205
R +K+K V +E P+V +L + + A+ + F + + +
Sbjct: 161 DR---NKKKKEVPKPECSESYTLTPEVGEL---IEKVRKAHQETFPALCQLGKYTTNNSS 214
Query: 206 SHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAK 265
V DI+ LW + E+S +C TV EFAK
Sbjct: 215 EQR---VSLDID-LWD---------------KFSELST----KCIIKTV-------EFAK 244
Query: 266 SIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGSGFVTREFLRSLRKP 323
+P F++L + DQ+TLLK + + + + +D + ++G + + P
Sbjct: 245 QLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP 304
Query: 324 FSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
+D++ F FA + LE+DD++ L A ++CG
Sbjct: 305 LTDLV---FAFANQLLPLEMDDAETGLLSAICLICG 337
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 125 bits (315), Expect = 4e-29
Identities = 98/332 (29%), Positives = 153/332 (46%), Gaps = 54/332 (16%)
Query: 32 GPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHAC 91
G H++ + S + SPPS + C VC DK+SG+HYGV AC
Sbjct: 51 GSNHSIETQSSSSEEIVPSPPS----------PPPLPRIYKPCFVCQDKSSGYHYGVSAC 100
Query: 92 EGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMP 149
EGCKGFFRR+I+ + Y C R +C I K RN+CQYCR QKC +GMS ++R R
Sbjct: 101 EGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR-- 157
Query: 150 EAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTA 209
+K+K V +E P+V +L + + A+ + F + + +
Sbjct: 158 -NKKKKEVPKPECSESYTLTPEVGEL---IEKVRKAHQETFPALCQLGKYTTNNSSEQR- 212
Query: 210 PFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPS 269
V DI+ LW + E+S +C TV EFAK +P
Sbjct: 213 --VSLDID-LWD---------------KFSELST----KCIIKTV-------EFAKQLPG 243
Query: 270 FSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGSGFVTREFLRSLRKPFSDI 327
F++L + DQ+TLLK + + + + +D + ++G + + P +D+
Sbjct: 244 FTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDL 303
Query: 328 IEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
+ F FA + LE+DD++ L A ++CG
Sbjct: 304 V---FAFANQLLPLEMDDAETGLLSAICLICG 332
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 125 bits (315), Expect = 4e-29
Identities = 101/336 (30%), Positives = 156/336 (46%), Gaps = 53/336 (15%)
Query: 34 QHALPSSSYTDLS------RSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYG 87
QH LP S Y+ S +SSS ++ + C VC DK+SG+HYG
Sbjct: 45 QHQLPVSGYSTPSPATIETQSSSSEEIVPSPP---SPPPLPRIYKPCFVCQDKSSGYHYG 101
Query: 88 VHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQKCLALGMSHNAIRF 145
V ACEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR QKC +GMS ++R
Sbjct: 102 VSACEGCKGFFRRSIQKNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRN 160
Query: 146 GRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKA 205
R +K+K V +E P+V +L + + A+ + F + + +
Sbjct: 161 DR---NKKKKEVPKPECSESYTLTPEVGEL---IEKVRKAHQETFPALCQLGKYTTNNSS 214
Query: 206 SHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAK 265
V DI+ LW + E+S +C TV EFAK
Sbjct: 215 EQR---VSLDID-LWD---------------KFSELST----KCIIKTV-------EFAK 244
Query: 266 SIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGSGFVTREFLRSLRKP 323
+P F++L + DQ+TLLK + + + + +D + ++G + + P
Sbjct: 245 QLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP 304
Query: 324 FSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
+D++ F FA + LE+DD++ L A ++CG
Sbjct: 305 LTDLV---FAFANQLLPLEMDDAETGLLSAICLICG 337
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 125 bits (314), Expect = 6e-29
Identities = 86/290 (29%), Positives = 136/290 (46%), Gaps = 44/290 (15%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C VC DK+SG+HYGV ACEGCKGFFRR+I+ + Y C R +C I K RN+CQYCR Q
Sbjct: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY-TCHRDKNCVINKVTRNRCQYCRLQ 139
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFN 191
KC +GMS ++R R +K+K + E + ++ DL ++ I A+ + F
Sbjct: 140 KCFEVGMSKESVRNDR---NKKKKETSKQECTESYEMTAELDDL---TEKIRKAHQETFP 193
Query: 192 MTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQC 251
+ + A H + LW L K ++
Sbjct: 194 SLCQLGKYTTNSSADHRVRLDL----GLWDKFSELATKCII------------------- 230
Query: 252 TTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLAS--IVNKDGLLVANGS 309
++ EFAK +P F+ L + DQ+TLLK + + + + +D + ++G
Sbjct: 231 -------KIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGL 283
Query: 310 GFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCG 359
+ + P +D++ F FA + LE+DD++ L A ++CG
Sbjct: 284 TLNRTQMHNAGFGPLTDLV---FTFANQLLPLEMDDTETGLLSAICLICG 330
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 121 bits (304), Expect = 8e-28
Identities = 94/283 (33%), Positives = 132/283 (46%), Gaps = 48/283 (16%)
Query: 31 GGPQHALPSSSYTDLSRSSSPPSLLDQLQMGC--DGASCGSLNMECRVCGDKASGFHYGV 88
G PQ + P + + P L L++ G C +CGD++SG HYGV
Sbjct: 90 GSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGV 149
Query: 89 HACEGCKGFFRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGR 147
++CEGCKGFF+RT+R L Y + + C I K+ RN+CQYCR+QKCLA+GM A++
Sbjct: 150 YSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQ--- 206
Query: 148 MPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASH 207
E+R+ G NE + A+ + I A L
Sbjct: 207 ----EERQ--RGKDRNENEVESTSSANEDMPVERILEAELA------------------- 241
Query: 208 TAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSI 267
V ET +A GL N P ++ CQ + + L E+AK I
Sbjct: 242 ----VEPKTETYVEANMGL------NPSSPNDPVT----NICQAAD-KQLFTLVEWAKRI 286
Query: 268 PSFSSLFLNDQVTLLKYGVHEAIFAMLA--SIVNKDGLLVANG 308
P FS L L+DQV LL+ G +E + A + SI KDG+L+A G
Sbjct: 287 PHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATG 329
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 113 bits (283), Expect = 2e-25
Identities = 103/333 (30%), Positives = 146/333 (43%), Gaps = 62/333 (18%)
Query: 36 ALPSSSYTDLSRSSSP------PSLLDQLQMGCDGASCGSLNME-CRVCGDKASGFHYGV 88
A PSS ++ SS P L M S GSL C +CGD++SG HYGV
Sbjct: 94 APPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGV 153
Query: 89 HACEGCKGFFRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGR 147
++CEGCKGFF+RTIR L Y + + C I K+ RN+CQYCR+QKCL +GM A++ R
Sbjct: 154 YSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEER 213
Query: 148 MPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASH 207
E+ + A A G + P + I A L T+ + +
Sbjct: 214 QRSRERAESEAE-CATSGHEDMP--------VERILEAELAVEPKTESYGDMNMENSTND 264
Query: 208 TAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSI 267
+ H + KQL T VE +AK I
Sbjct: 265 PVTNICHAAD-----------KQLF-------------------TLVE-------WAKRI 287
Query: 268 PSFSSLFLNDQVTLLKYGVHEAIFAMLA--SIVNKDGLLVANGSGFVTREFLRS--LRKP 323
P FS L L DQV LL+ G +E + A + S+ +DG+L+A G V R S +
Sbjct: 288 PHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGL-HVHRSSAHSAGVGSI 346
Query: 324 FSDIIEPKFEFAVKFNALELDDSDLALFIAAII 356
F ++ E K +++D S+L A ++
Sbjct: 347 FDRVLT---ELVSKMKDMQMDKSELGCLRAIVL 376
>gi|19743907 RAR-related orphan receptor B [Homo sapiens]
Length = 459
Score = 112 bits (281), Expect = 4e-25
Identities = 54/121 (44%), Positives = 81/121 (66%), Gaps = 7/121 (5%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKC--ERSCKIQKKNRNKCQYCRFQ 131
C++CGDK+SG HYGV CEGCKGFFRR+ + Y C +R+C I + NRN+CQ+CR Q
Sbjct: 10 CKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYS-CPRQRNCLIDRTNRNRCQHCRLQ 68
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVAGLTANE---GSQYNPQVADLKAFSKHIYNAYLK 188
KCLALGMS +A++FGRM + ++ L A + ++ Q Q + +A ++ +Y++ +
Sbjct: 69 KCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALAR-VYSSSIS 127
Query: 189 N 189
N
Sbjct: 128 N 128
Score = 51.6 bits (122), Expect = 1e-06
Identities = 32/127 (25%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 238 YKEISVH-------VFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAI 290
Y+EI + ++ +C ++ + EFAK I F L NDQ+ LLK G E +
Sbjct: 244 YEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVV 303
Query: 291 FAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLAL 350
+ N V + + ++L D++ F+FA +L+L + ++AL
Sbjct: 304 LVRMCRAFNPLNNTVLFEGKYGGMQMFKALGS--DDLVNEAFDFAKNLCSLQLTEEEIAL 361
Query: 351 FIAAIIL 357
F +A+++
Sbjct: 362 FSSAVLI 368
>gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens]
Length = 497
Score = 109 bits (272), Expect = 4e-24
Identities = 49/87 (56%), Positives = 64/87 (73%), Gaps = 3/87 (3%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C++CGDK+SG HYGV CEGCKGFFRR+ R Y C R +C I + +RN+CQ+CR Q
Sbjct: 10 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHCRLQ 68
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVA 158
KCLALGMS +A++FGRM + ++ L A
Sbjct: 69 KCLALGMSRDAVKFGRMSKKQRDSLHA 95
Score = 56.6 bits (135), Expect = 3e-08
Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 6/143 (4%)
Query: 216 IETLWQAEKGLVWKQLVNGLPPYKEISV-HVFYRCQCTTVETVRELTEFAKSIPSFSSLF 274
+E L + + ++ V G Y+ S+ ++ RC E ++ + EFAK + F L
Sbjct: 268 LEDLLRQRSNIFSREEVTG---YQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELC 324
Query: 275 LNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEF 334
NDQ+ LLK G E + + N D V + E R+L S++I F+F
Sbjct: 325 QNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRAL--GCSELISSIFDF 382
Query: 335 AVKFNALELDDSDLALFIAAIIL 357
+ +AL + ++AL+ A +++
Sbjct: 383 SHSLSALHFSEDEIALYTALVLI 405
>gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens]
Length = 518
Score = 109 bits (272), Expect = 4e-24
Identities = 49/87 (56%), Positives = 64/87 (73%), Gaps = 3/87 (3%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C++CGDK+SG HYGV CEGCKGFFRR+ R Y C R +C I + +RN+CQ+CR Q
Sbjct: 31 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHCRLQ 89
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVA 158
KCLALGMS +A++FGRM + ++ L A
Sbjct: 90 KCLALGMSRDAVKFGRMSKKQRDSLHA 116
Score = 56.6 bits (135), Expect = 3e-08
Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 6/143 (4%)
Query: 216 IETLWQAEKGLVWKQLVNGLPPYKEISV-HVFYRCQCTTVETVRELTEFAKSIPSFSSLF 274
+E L + + ++ V G Y+ S+ ++ RC E ++ + EFAK + F L
Sbjct: 289 LEDLLRQRSNIFSREEVTG---YQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELC 345
Query: 275 LNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEF 334
NDQ+ LLK G E + + N D V + E R+L S++I F+F
Sbjct: 346 QNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRAL--GCSELISSIFDF 403
Query: 335 AVKFNALELDDSDLALFIAAIIL 357
+ +AL + ++AL+ A +++
Sbjct: 404 SHSLSALHFSEDEIALYTALVLI 426
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 107 bits (267), Expect = 2e-23
Identities = 95/360 (26%), Positives = 152/360 (42%), Gaps = 53/360 (14%)
Query: 15 EEKEEVAEAEGAPELNG-----GPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGS 69
E+K E PE N G + S S PS LD+
Sbjct: 2 EQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDK------------ 49
Query: 70 LNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKL------EYEKCERSCKIQKKNRN 123
+ +C VCGDKA+G+HY CEGCKGFFRRTI+ L +Y+ C C I K RN
Sbjct: 50 -DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSC---CVIDKITRN 105
Query: 124 KCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIY 183
+CQ CRF+KC+A+GM+ + + KRKL+ E + + L+ +
Sbjct: 106 QCQLCRFKKCIAVGMAMDLV-LDDSKRVAKRKLIE--QNRERRRKEEMIRSLQQRPEPTP 162
Query: 184 NAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGL----VWKQLVNGLPPYK 239
+ + +A + SH W+ + + + + +P
Sbjct: 163 EEW--DLIHIATEAHRSTNAQGSH------------WKQRRKFLPDDIGQSPIVSMPDGD 208
Query: 240 EISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASI-- 297
++ + F + + +FAK +P FS L DQ+ LLK G I ++ A++
Sbjct: 209 KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLK-GCCMEIMSLRAAVRY 267
Query: 298 VNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIIL 357
+ L +G V RE L++ + + FE +A LDD+++AL A +++
Sbjct: 268 DPESDTLTLSGEMAVKREQLKN--GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLM 325
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 107 bits (267), Expect = 2e-23
Identities = 95/360 (26%), Positives = 152/360 (42%), Gaps = 53/360 (14%)
Query: 15 EEKEEVAEAEGAPELNG-----GPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGS 69
E+K E PE N G + S S PS LD+
Sbjct: 2 EQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDK------------ 49
Query: 70 LNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKL------EYEKCERSCKIQKKNRN 123
+ +C VCGDKA+G+HY CEGCKGFFRRTI+ L +Y+ C C I K RN
Sbjct: 50 -DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSC---CVIDKITRN 105
Query: 124 KCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIY 183
+CQ CRF+KC+A+GM+ + + KRKL+ E + + L+ +
Sbjct: 106 QCQLCRFKKCIAVGMAMDLV-LDDSKRVAKRKLIE--QNRERRRKEEMIRSLQQRPEPTP 162
Query: 184 NAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGL----VWKQLVNGLPPYK 239
+ + +A + SH W+ + + + + +P
Sbjct: 163 EEW--DLIHIATEAHRSTNAQGSH------------WKQRRKFLPDDIGQSPIVSMPDGD 208
Query: 240 EISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASI-- 297
++ + F + + +FAK +P FS L DQ+ LLK G I ++ A++
Sbjct: 209 KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLK-GCCMEIMSLRAAVRY 267
Query: 298 VNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIIL 357
+ L +G V RE L++ + + FE +A LDD+++AL A +++
Sbjct: 268 DPESDTLTLSGEMAVKREQLKN--GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLM 325
>gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens]
Length = 468
Score = 107 bits (266), Expect = 2e-23
Identities = 47/87 (54%), Positives = 64/87 (73%), Gaps = 3/87 (3%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C++CGDK+SG HYGV CEGCKGFFRR+ + Y C R +C I + +RN+CQ+CR Q
Sbjct: 18 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHCRLQ 76
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVA 158
KCLA+GMS +A++FGRM + ++ L A
Sbjct: 77 KCLAVGMSRDAVKFGRMSKKQRDSLYA 103
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/186 (21%), Positives = 79/186 (42%), Gaps = 26/186 (13%)
Query: 172 VADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQL 231
+A+L+ +++I ++L+ +++ + I F+ +IE ++ ++W+
Sbjct: 215 MAELEHLAQNISKSHLETCQYLREELQQITW------QTFLQEEIENYQNKQREVMWQL- 267
Query: 232 VNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIF 291
C E ++ + EFAK I F L NDQ+ LLK G E +F
Sbjct: 268 -----------------CAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVF 310
Query: 292 AMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALF 351
+ + V + + + +SL D I FEF ++ L + ++ALF
Sbjct: 311 IRMCRAFDSQNNTVYFDGKYASPDVFKSL--GCEDFISFVFEFGKSLCSMHLTEDEIALF 368
Query: 352 IAAIIL 357
A +++
Sbjct: 369 SAFVLM 374
>gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens]
Length = 548
Score = 107 bits (266), Expect = 2e-23
Identities = 47/87 (54%), Positives = 64/87 (73%), Gaps = 3/87 (3%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C++CGDK+SG HYGV CEGCKGFFRR+ + Y C R +C I + +RN+CQ+CR Q
Sbjct: 98 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHCRLQ 156
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVA 158
KCLA+GMS +A++FGRM + ++ L A
Sbjct: 157 KCLAVGMSRDAVKFGRMSKKQRDSLYA 183
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/186 (21%), Positives = 79/186 (42%), Gaps = 26/186 (13%)
Query: 172 VADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQL 231
+A+L+ +++I ++L+ +++ + I F+ +IE ++ ++W+
Sbjct: 295 MAELEHLAQNISKSHLETCQYLREELQQITW------QTFLQEEIENYQNKQREVMWQL- 347
Query: 232 VNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIF 291
C E ++ + EFAK I F L NDQ+ LLK G E +F
Sbjct: 348 -----------------CAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVF 390
Query: 292 AMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALF 351
+ + V + + + +SL D I FEF ++ L + ++ALF
Sbjct: 391 IRMCRAFDSQNNTVYFDGKYASPDVFKSL--GCEDFISFVFEFGKSLCSMHLTEDEIALF 448
Query: 352 IAAIIL 357
A +++
Sbjct: 449 SAFVLM 454
>gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens]
Length = 556
Score = 107 bits (266), Expect = 2e-23
Identities = 47/87 (54%), Positives = 64/87 (73%), Gaps = 3/87 (3%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C++CGDK+SG HYGV CEGCKGFFRR+ + Y C R +C I + +RN+CQ+CR Q
Sbjct: 106 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHCRLQ 164
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVA 158
KCLA+GMS +A++FGRM + ++ L A
Sbjct: 165 KCLAVGMSRDAVKFGRMSKKQRDSLYA 191
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/186 (21%), Positives = 79/186 (42%), Gaps = 26/186 (13%)
Query: 172 VADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQL 231
+A+L+ +++I ++L+ +++ + I F+ +IE ++ ++W+
Sbjct: 303 MAELEHLAQNISKSHLETCQYLREELQQITW------QTFLQEEIENYQNKQREVMWQL- 355
Query: 232 VNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIF 291
C E ++ + EFAK I F L NDQ+ LLK G E +F
Sbjct: 356 -----------------CAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVF 398
Query: 292 AMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALF 351
+ + V + + + +SL D I FEF ++ L + ++ALF
Sbjct: 399 IRMCRAFDSQNNTVYFDGKYASPDVFKSL--GCEDFISFVFEFGKSLCSMHLTEDEIALF 456
Query: 352 IAAIIL 357
A +++
Sbjct: 457 SAFVLM 462
>gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens]
Length = 523
Score = 107 bits (266), Expect = 2e-23
Identities = 47/87 (54%), Positives = 64/87 (73%), Gaps = 3/87 (3%)
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCER--SCKIQKKNRNKCQYCRFQ 131
C++CGDK+SG HYGV CEGCKGFFRR+ + Y C R +C I + +RN+CQ+CR Q
Sbjct: 73 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYS-CPRQKNCLIDRTSRNRCQHCRLQ 131
Query: 132 KCLALGMSHNAIRFGRMPEAEKRKLVA 158
KCLA+GMS +A++FGRM + ++ L A
Sbjct: 132 KCLAVGMSRDAVKFGRMSKKQRDSLYA 158
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/186 (21%), Positives = 79/186 (42%), Gaps = 26/186 (13%)
Query: 172 VADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQL 231
+A+L+ +++I ++L+ +++ + I F+ +IE ++ ++W+
Sbjct: 270 MAELEHLAQNISKSHLETCQYLREELQQITW------QTFLQEEIENYQNKQREVMWQL- 322
Query: 232 VNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIF 291
C E ++ + EFAK I F L NDQ+ LLK G E +F
Sbjct: 323 -----------------CAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVF 365
Query: 292 AMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALF 351
+ + V + + + +SL D I FEF ++ L + ++ALF
Sbjct: 366 IRMCRAFDSQNNTVYFDGKYASPDVFKSL--GCEDFISFVFEFGKSLCSMHLTEDEIALF 423
Query: 352 IAAIIL 357
A +++
Sbjct: 424 SAFVLM 429
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 106 bits (264), Expect = 4e-23
Identities = 56/137 (40%), Positives = 76/137 (55%), Gaps = 9/137 (6%)
Query: 26 APELNGGPQHALPSSSYTDL-SRSSSPPSLLDQLQMGCDGASC-------GSLNMECRVC 77
AP GP + +S L S PP + +G G C G+ C +C
Sbjct: 149 APPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAIC 208
Query: 78 GDKASGFHYGVHACEGCKGFFRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQKCLAL 136
GD++SG HYGV++CEGCKGFF+RTIR L Y + + C + K+ RN+CQYCR+QKCLA
Sbjct: 209 GDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLAT 268
Query: 137 GMSHNAIRFGRMPEAEK 153
GM A++ R +K
Sbjct: 269 GMKREAVQEERQRGKDK 285
Score = 44.3 bits (103), Expect = 2e-04
Identities = 26/51 (50%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Query: 260 LTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLA--SIVNKDGLLVANG 308
L E+AK IP FSSL L+DQV LL+ G +E + A + SI +DG+L+A G
Sbjct: 350 LVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATG 400
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 106 bits (264), Expect = 4e-23
Identities = 53/140 (37%), Positives = 79/140 (56%), Gaps = 14/140 (10%)
Query: 14 EEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNME 73
E++++ + A P+ G P P++ T + PP G+ ++E
Sbjct: 39 EQQQQAGSGAPHTPQTPGQP--GAPATPGTAGDKGQGPP-----------GSGQSQQHIE 85
Query: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE-KCERSCKIQKKNRNKCQYCRFQK 132
C VCGDK+SG HYG CEGCK FF+R++R L Y + R+C I + +RN+CQYCR +K
Sbjct: 86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKK 145
Query: 133 CLALGMSHNAIRFGRMPEAE 152
CL +GM A++ GRMP +
Sbjct: 146 CLKVGMRREAVQRGRMPPTQ 165
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,376,152
Number of Sequences: 37866
Number of extensions: 652846
Number of successful extensions: 5290
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 143
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 4518
Number of HSP's gapped (non-prelim): 549
length of query: 361
length of database: 18,247,518
effective HSP length: 104
effective length of query: 257
effective length of database: 14,309,454
effective search space: 3677529678
effective search space used: 3677529678
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.