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Search of human proteins with 28827807
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28827807 NLR family, pyrin domain containing 10 [Homo
sapiens]
(655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 1313 0.0
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 356 3e-98
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 356 3e-98
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 356 3e-98
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 356 3e-98
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 356 3e-98
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 346 4e-95
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 252 9e-67
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 252 9e-67
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 252 9e-67
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 252 9e-67
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 252 9e-67
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 251 2e-66
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 245 8e-65
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 226 5e-59
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 219 8e-57
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 219 8e-57
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 219 8e-57
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 206 4e-53
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 202 6e-52
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 183 5e-46
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 181 2e-45
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 173 5e-43
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 144 3e-34
gi|11545912 nucleotide-binding oligomerization domain containing... 104 2e-22
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 91 3e-18
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens] 83 9e-16
gi|25777610 NLR family member X1 isoform 2 [Homo sapiens] 83 9e-16
gi|156938336 class II transactivator [Homo sapiens] 79 2e-14
gi|118918429 NOD3 protein [Homo sapiens] 79 2e-14
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 1313 bits (3399), Expect = 0.0
Identities = 655/655 (100%), Positives = 655/655 (100%)
Query: 1 MAMAKARKPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAEL 60
MAMAKARKPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAEL
Sbjct: 1 MAMAKARKPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAEL 60
Query: 61 LISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGR 120
LISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGR
Sbjct: 61 LISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGR 120
Query: 121 YNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKT 180
YNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKT
Sbjct: 121 YNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKT 180
Query: 181 TLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQ 240
TLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQ
Sbjct: 181 TLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQ 240
Query: 241 PERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNL 300
PERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNL
Sbjct: 241 PERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNL 300
Query: 301 EPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVV 360
EPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVV
Sbjct: 301 EPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVV 360
Query: 361 CSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEG 420
CSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEG
Sbjct: 361 CSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEG 420
Query: 421 IQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLV 480
IQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLV
Sbjct: 421 IQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLV 480
Query: 481 KEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPC 540
KEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPC
Sbjct: 481 KEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPC 540
Query: 541 LAQDLKHFKEQMESMKHNRTWDLEFSLYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQSQN 600
LAQDLKHFKEQMESMKHNRTWDLEFSLYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQSQN
Sbjct: 541 LAQDLKHFKEQMESMKHNRTWDLEFSLYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQSQN 600
Query: 601 LFSVKSSLSHGPKEEQKCPSVHGQKEGKDNIAGTQKEASTGKGRGTEETPKNTYI 655
LFSVKSSLSHGPKEEQKCPSVHGQKEGKDNIAGTQKEASTGKGRGTEETPKNTYI
Sbjct: 601 LFSVKSSLSHGPKEEQKCPSVHGQKEGKDNIAGTQKEASTGKGRGTEETPKNTYI 655
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 356 bits (914), Expect = 3e-98
Identities = 236/639 (36%), Positives = 347/639 (54%), Gaps = 86/639 (13%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L DLE+ D KK K +L D +G PL RG+ E VDLA L+I GE++A + +
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 77 GLKVMN----------------------------------------LLELVDQLSHICL- 95
+N LLE + ++S IC
Sbjct: 74 IFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRIS-ICKM 132
Query: 96 -HDYREVYREHVR----CLEE-----WQEAGVNGRYNQVLLVAKPSSESP---ESLACPF 142
DYR+ YR++VR C+E+ + +N RY ++ L+ + S+ E LA
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 143 P---EQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGR 199
E + + +E LFD ++ S VV QG+AG GKT LARKM+LDWA+GTLY R
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 200 FDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFE 259
FDY+FY+ C+EV L+ + L L+ CC D P+ +I+R+P R+LF++DGFDELQ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 260 EKL---------KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHV 310
E + +RG + LL LIR+ LP SLLITTRP+AL L+ LL RHV
Sbjct: 313 EHIGPLCTDWQKAERG----DILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV 368
Query: 311 HILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMER 370
ILGFSE +R YF YF+DE QA AF ++Q+N++L+ C +P +CW+VC+ L+ QME
Sbjct: 369 EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES 428
Query: 371 GKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430
GK + +T + +T +++ ++S+ L P GG E L LCSLAA+GI +Q+ LFEE
Sbjct: 429 GKSLAQTSKTTTAVYVFFLSSLLQP--RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQ------ 484
++LR H L ++AFL N +Q + +KFYSF H++FQ+FF AM YL++E++
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNV 546
Query: 485 --SRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
SRL K R+V LLE + + ++FL + ++ S LE K +IS +
Sbjct: 547 PGSRL-KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIR 605
Query: 543 QDLKHFKEQMESMK----HNRTWDLEFSLYEAKIKNLVK 577
+L + E K +L + LYE + ++ V+
Sbjct: 606 LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ 644
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 356 bits (914), Expect = 3e-98
Identities = 236/639 (36%), Positives = 347/639 (54%), Gaps = 86/639 (13%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L DLE+ D KK K +L D +G PL RG+ E VDLA L+I GE++A + +
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 77 GLKVMN----------------------------------------LLELVDQLSHICL- 95
+N LLE + ++S IC
Sbjct: 74 IFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRIS-ICKM 132
Query: 96 -HDYREVYREHVR----CLEE-----WQEAGVNGRYNQVLLVAKPSSESP---ESLACPF 142
DYR+ YR++VR C+E+ + +N RY ++ L+ + S+ E LA
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 143 P---EQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGR 199
E + + +E LFD ++ S VV QG+AG GKT LARKM+LDWA+GTLY R
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 200 FDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFE 259
FDY+FY+ C+EV L+ + L L+ CC D P+ +I+R+P R+LF++DGFDELQ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 260 EKL---------KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHV 310
E + +RG + LL LIR+ LP SLLITTRP+AL L+ LL RHV
Sbjct: 313 EHIGPLCTDWQKAERG----DILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV 368
Query: 311 HILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMER 370
ILGFSE +R YF YF+DE QA AF ++Q+N++L+ C +P +CW+VC+ L+ QME
Sbjct: 369 EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES 428
Query: 371 GKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430
GK + +T + +T +++ ++S+ L P GG E L LCSLAA+GI +Q+ LFEE
Sbjct: 429 GKSLAQTSKTTTAVYVFFLSSLLQP--RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQ------ 484
++LR H L ++AFL N +Q + +KFYSF H++FQ+FF AM YL++E++
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNV 546
Query: 485 --SRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
SRL K R+V LLE + + ++FL + ++ S LE K +IS +
Sbjct: 547 PGSRL-KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIR 605
Query: 543 QDLKHFKEQMESMK----HNRTWDLEFSLYEAKIKNLVK 577
+L + E K +L + LYE + ++ V+
Sbjct: 606 LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ 644
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 356 bits (914), Expect = 3e-98
Identities = 236/639 (36%), Positives = 347/639 (54%), Gaps = 86/639 (13%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L DLE+ D KK K +L D +G PL RG+ E VDLA L+I GE++A + +
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 77 GLKVMN----------------------------------------LLELVDQLSHICL- 95
+N LLE + ++S IC
Sbjct: 74 IFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRIS-ICKM 132
Query: 96 -HDYREVYREHVR----CLEE-----WQEAGVNGRYNQVLLVAKPSSESP---ESLACPF 142
DYR+ YR++VR C+E+ + +N RY ++ L+ + S+ E LA
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 143 P---EQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGR 199
E + + +E LFD ++ S VV QG+AG GKT LARKM+LDWA+GTLY R
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 200 FDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFE 259
FDY+FY+ C+EV L+ + L L+ CC D P+ +I+R+P R+LF++DGFDELQ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 260 EKL---------KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHV 310
E + +RG + LL LIR+ LP SLLITTRP+AL L+ LL RHV
Sbjct: 313 EHIGPLCTDWQKAERG----DILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV 368
Query: 311 HILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMER 370
ILGFSE +R YF YF+DE QA AF ++Q+N++L+ C +P +CW+VC+ L+ QME
Sbjct: 369 EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES 428
Query: 371 GKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430
GK + +T + +T +++ ++S+ L P GG E L LCSLAA+GI +Q+ LFEE
Sbjct: 429 GKSLAQTSKTTTAVYVFFLSSLLQP--RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQ------ 484
++LR H L ++AFL N +Q + +KFYSF H++FQ+FF AM YL++E++
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNV 546
Query: 485 --SRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
SRL K R+V LLE + + ++FL + ++ S LE K +IS +
Sbjct: 547 PGSRL-KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIR 605
Query: 543 QDLKHFKEQMESMK----HNRTWDLEFSLYEAKIKNLVK 577
+L + E K +L + LYE + ++ V+
Sbjct: 606 LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ 644
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 356 bits (914), Expect = 3e-98
Identities = 236/639 (36%), Positives = 347/639 (54%), Gaps = 86/639 (13%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L DLE+ D KK K +L D +G PL RG+ E VDLA L+I GE++A + +
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 77 GLKVMN----------------------------------------LLELVDQLSHICL- 95
+N LLE + ++S IC
Sbjct: 74 IFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRIS-ICKM 132
Query: 96 -HDYREVYREHVR----CLEE-----WQEAGVNGRYNQVLLVAKPSSESP---ESLACPF 142
DYR+ YR++VR C+E+ + +N RY ++ L+ + S+ E LA
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 143 P---EQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGR 199
E + + +E LFD ++ S VV QG+AG GKT LARKM+LDWA+GTLY R
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 200 FDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFE 259
FDY+FY+ C+EV L+ + L L+ CC D P+ +I+R+P R+LF++DGFDELQ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 260 EKL---------KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHV 310
E + +RG + LL LIR+ LP SLLITTRP+AL L+ LL RHV
Sbjct: 313 EHIGPLCTDWQKAERG----DILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV 368
Query: 311 HILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMER 370
ILGFSE +R YF YF+DE QA AF ++Q+N++L+ C +P +CW+VC+ L+ QME
Sbjct: 369 EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES 428
Query: 371 GKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430
GK + +T + +T +++ ++S+ L P GG E L LCSLAA+GI +Q+ LFEE
Sbjct: 429 GKSLAQTSKTTTAVYVFFLSSLLQP--RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQ------ 484
++LR H L ++AFL N +Q + +KFYSF H++FQ+FF AM YL++E++
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNV 546
Query: 485 --SRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
SRL K R+V LLE + + ++FL + ++ S LE K +IS +
Sbjct: 547 PGSRL-KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIR 605
Query: 543 QDLKHFKEQMESMK----HNRTWDLEFSLYEAKIKNLVK 577
+L + E K +L + LYE + ++ V+
Sbjct: 606 LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ 644
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 356 bits (914), Expect = 3e-98
Identities = 236/639 (36%), Positives = 347/639 (54%), Gaps = 86/639 (13%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L DLE+ D KK K +L D +G PL RG+ E VDLA L+I GE++A + +
Sbjct: 14 LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
Query: 77 GLKVMN----------------------------------------LLELVDQLSHICL- 95
+N LLE + ++S IC
Sbjct: 74 IFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRIS-ICKM 132
Query: 96 -HDYREVYREHVR----CLEE-----WQEAGVNGRYNQVLLVAKPSSESP---ESLACPF 142
DYR+ YR++VR C+E+ + +N RY ++ L+ + S+ E LA
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 143 P---EQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGR 199
E + + +E LFD ++ S VV QG+AG GKT LARKM+LDWA+GTLY R
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 200 FDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFE 259
FDY+FY+ C+EV L+ + L L+ CC D P+ +I+R+P R+LF++DGFDELQ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 260 EKL---------KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHV 310
E + +RG + LL LIR+ LP SLLITTRP+AL L+ LL RHV
Sbjct: 313 EHIGPLCTDWQKAERG----DILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV 368
Query: 311 HILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMER 370
ILGFSE +R YF YF+DE QA AF ++Q+N++L+ C +P +CW+VC+ L+ QME
Sbjct: 369 EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES 428
Query: 371 GKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430
GK + +T + +T +++ ++S+ L P GG E L LCSLAA+GI +Q+ LFEE
Sbjct: 429 GKSLAQTSKTTTAVYVFFLSSLLQP--RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQ------ 484
++LR H L ++AFL N +Q + +KFYSF H++FQ+FF AM YL++E++
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNV 546
Query: 485 --SRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
SRL K R+V LLE + + ++FL + ++ S LE K +IS +
Sbjct: 547 PGSRL-KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIR 605
Query: 543 QDLKHFKEQMESMK----HNRTWDLEFSLYEAKIKNLVK 577
+L + E K +L + LYE + ++ V+
Sbjct: 606 LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ 644
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 346 bits (887), Expect = 4e-95
Identities = 225/639 (35%), Positives = 348/639 (54%), Gaps = 73/639 (11%)
Query: 17 LSDLEENDFKKLKFYLRDMT-LSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVL 75
L +LE + KK K YL T L EG+ P G +E P+++A+LLI+ +G +EA ++ L
Sbjct: 17 LEELEAVELKKFKLYLGTATELGEGKIPW--GSMEKAGPLEMAQLLITHFGPEEAWRLAL 74
Query: 76 KGLKVMNLLELVDQLSH-------------------ICL---------HDYREVYREHVR 107
+ +N +L ++ CL D +E YR++VR
Sbjct: 75 STFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVR 134
Query: 108 CLEEWQE---------AGVNGRYNQVLLVAKPSSESPESLACPFPE----------QELE 148
E ++ RY ++LLV + S+ P + + +
Sbjct: 135 RKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSN--PMQVQQQLLDTGRGHARTVGHQAS 192
Query: 149 SVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSC 208
+ +E LF+ E+ P VV+QG+AG GK+ LA K++LDWA G L+ GRFDY+FY++C
Sbjct: 193 PIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINC 252
Query: 209 KEV-VLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEK-----L 262
+E+ E ++ L+F C + AP+ E++R PERLLFI+DGFDEL+ F + L
Sbjct: 253 REMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCL 312
Query: 263 KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERAR 322
P E LL+ LIR+ LP SLLITTRP AL L LL+ RHV ILGFSE ER
Sbjct: 313 CWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKE 372
Query: 323 YFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNST 382
YF YF + +QA + F+ V+ N+ L+ C VP +CWVVC+ LQ Q+E G ++ +T R +T
Sbjct: 373 YFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTT 432
Query: 383 DIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPR 442
++M Y+ + + P G L R LCSLAA+G+ +Q+ LFEE +LRKH LDG
Sbjct: 433 AVYMLYLLSLMQPKP--GAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGED 490
Query: 443 LAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVK 502
++AFL+ N +Q + +++YSF H+SFQ+FF AM Y++ E + G + ++V RLL
Sbjct: 491 VSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPD--QDVTRLLTEY 548
Query: 503 EQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHN--RT 560
+ LT +FL + +++ S+LE C+++SP + DL + + + +
Sbjct: 549 AFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQ 608
Query: 561 WDLEF--SLYEAKIKNLVKG-------IQMNNVSFKIKH 590
LEF LYE + + ++ I ++N++ K++H
Sbjct: 609 GSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 252 bits (643), Expect = 9e-67
Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)
Query: 96 HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150
H + RE + W+ N ++ Q+LL+ +P S + L +P+ E+ +
Sbjct: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
Query: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210
+ LF G + P +V+LQG+AG GK+TLAR++ W G LY RF +VFY SC+E
Sbjct: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
Query: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265
+ L +L+ AP+ +IL +PERLLFILDG DE LQ P E L
Sbjct: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
Query: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
P ++LL L+ + LP S LIT R AL+NL P L+QAR V +LGFSE R YF
Sbjct: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
Query: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
YFTDE+QA RAF +V+ N L+ C VP + W+ C+ L QM+R + + T + +T +
Sbjct: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
Query: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
+ Y++ L G LR LCSLAAEGI ++ LF +LRKH LDG ++
Sbjct: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
Query: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503
FL Q I YSF H+ FQ+FF AMSY++++++ R GK S ++++ LE
Sbjct: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
Query: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563
G + T +FLL + + +E F R+S ++L + ++ + + +
Sbjct: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
Query: 564 EFSLYEAKIKNLV 576
LYE + K +
Sbjct: 719 LHCLYETRNKTFL 731
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 252 bits (643), Expect = 9e-67
Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)
Query: 96 HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150
H + RE + W+ N ++ Q+LL+ +P S + L +P+ E+ +
Sbjct: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
Query: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210
+ LF G + P +V+LQG+AG GK+TLAR++ W G LY RF +VFY SC+E
Sbjct: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
Query: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265
+ L +L+ AP+ +IL +PERLLFILDG DE LQ P E L
Sbjct: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
Query: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
P ++LL L+ + LP S LIT R AL+NL P L+QAR V +LGFSE R YF
Sbjct: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
Query: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
YFTDE+QA RAF +V+ N L+ C VP + W+ C+ L QM+R + + T + +T +
Sbjct: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
Query: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
+ Y++ L G LR LCSLAAEGI ++ LF +LRKH LDG ++
Sbjct: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
Query: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503
FL Q I YSF H+ FQ+FF AMSY++++++ R GK S ++++ LE
Sbjct: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
Query: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563
G + T +FLL + + +E F R+S ++L + ++ + + +
Sbjct: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
Query: 564 EFSLYEAKIKNLV 576
LYE + K +
Sbjct: 719 LHCLYETRNKTFL 731
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 252 bits (643), Expect = 9e-67
Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)
Query: 96 HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150
H + RE + W+ N ++ Q+LL+ +P S + L +P+ E+ +
Sbjct: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
Query: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210
+ LF G + P +V+LQG+AG GK+TLAR++ W G LY RF +VFY SC+E
Sbjct: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
Query: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265
+ L +L+ AP+ +IL +PERLLFILDG DE LQ P E L
Sbjct: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
Query: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
P ++LL L+ + LP S LIT R AL+NL P L+QAR V +LGFSE R YF
Sbjct: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
Query: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
YFTDE+QA RAF +V+ N L+ C VP + W+ C+ L QM+R + + T + +T +
Sbjct: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
Query: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
+ Y++ L G LR LCSLAAEGI ++ LF +LRKH LDG ++
Sbjct: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
Query: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503
FL Q I YSF H+ FQ+FF AMSY++++++ R GK S ++++ LE
Sbjct: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
Query: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563
G + T +FLL + + +E F R+S ++L + ++ + + +
Sbjct: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
Query: 564 EFSLYEAKIKNLV 576
LYE + K +
Sbjct: 719 LHCLYETRNKTFL 731
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 252 bits (643), Expect = 9e-67
Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)
Query: 96 HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150
H + RE + W+ N ++ Q+LL+ +P S + L +P+ E+ +
Sbjct: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
Query: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210
+ LF G + P +V+LQG+AG GK+TLAR++ W G LY RF +VFY SC+E
Sbjct: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
Query: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265
+ L +L+ AP+ +IL +PERLLFILDG DE LQ P E L
Sbjct: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
Query: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
P ++LL L+ + LP S LIT R AL+NL P L+QAR V +LGFSE R YF
Sbjct: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
Query: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
YFTDE+QA RAF +V+ N L+ C VP + W+ C+ L QM+R + + T + +T +
Sbjct: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
Query: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
+ Y++ L G LR LCSLAAEGI ++ LF +LRKH LDG ++
Sbjct: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
Query: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503
FL Q I YSF H+ FQ+FF AMSY++++++ R GK S ++++ LE
Sbjct: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
Query: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563
G + T +FLL + + +E F R+S ++L + ++ + + +
Sbjct: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
Query: 564 EFSLYEAKIKNLV 576
LYE + K +
Sbjct: 719 LHCLYETRNKTFL 731
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 252 bits (643), Expect = 9e-67
Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)
Query: 96 HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150
H + RE + W+ N ++ Q+LL+ +P S + L +P+ E+ +
Sbjct: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
Query: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210
+ LF G + P +V+LQG+AG GK+TLAR++ W G LY RF +VFY SC+E
Sbjct: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
Query: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265
+ L +L+ AP+ +IL +PERLLFILDG DE LQ P E L
Sbjct: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
Query: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
P ++LL L+ + LP S LIT R AL+NL P L+QAR V +LGFSE R YF
Sbjct: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
Query: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
YFTDE+QA RAF +V+ N L+ C VP + W+ C+ L QM+R + + T + +T +
Sbjct: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
Query: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
+ Y++ L G LR LCSLAAEGI ++ LF +LRKH LDG ++
Sbjct: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
Query: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503
FL Q I YSF H+ FQ+FF AMSY++++++ R GK S ++++ LE
Sbjct: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
Query: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563
G + T +FLL + + +E F R+S ++L + ++ + + +
Sbjct: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
Query: 564 EFSLYEAKIKNLV 576
LYE + K +
Sbjct: 719 LHCLYETRNKTFL 731
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 251 bits (640), Expect = 2e-66
Identities = 186/591 (31%), Positives = 284/591 (48%), Gaps = 29/591 (4%)
Query: 9 PREALLWALSDLEENDFKKLKFYLRD-MTLSEGQPPLARGELEGLIPVDLAELLISKYGE 67
P LL L +L + + K +L++ M G P E++ DLA L+ Y
Sbjct: 11 PDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPG 68
Query: 68 KEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLE--EWQEAGVN------G 119
++A V LK MNL +L ++ + + + + E E QEA +
Sbjct: 69 EKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRN 128
Query: 120 RYNQVLLVA---KPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAG 176
R + + K + PE E++ + +E LFD K P +VVLQG+AG
Sbjct: 129 RIKEKFCITWDKKSLAGKPEDFHHGIAEKDRK--LLEHLFDVDVKTGAQPQIVVLQGAAG 186
Query: 177 TGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTE 236
GKTTL RK +LDWA G+LY RF YVFY++ +E+ L E QL+ + P+ E
Sbjct: 187 VGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEE 246
Query: 237 ILRQPERLLFILDGFDELQRPFEEK-----LKKRGLSPKESLLHLLIRRHTLPTCSLLIT 291
I+ QP LLFI+D FDEL FEE P L+ L+R+ LP SLL+T
Sbjct: 247 IMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVT 306
Query: 292 TRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKAC 351
TR + L+ LLK +V +LG SE+ R Y +F D++ A + F ++ N++L+ C
Sbjct: 307 TRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMC 366
Query: 352 QVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLR 411
QVP +CW C+ L+ QME+G V T + +T +F Y+S+ P DGG L LR
Sbjct: 367 QVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTP-VDGGSPSLPNQAQLR 425
Query: 412 SLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQD 471
LC +AA+GI ++F LR+ L +++F+ SN Q + Y F H+ Q+
Sbjct: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
Query: 472 FFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQ--FLLDISKKDSFSNL 529
FF AM Y++K G S + + L + + + LT FL + +D L
Sbjct: 486 FFAAMFYMLK-GSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQL 544
Query: 530 ELKFCFRISPCLAQDLKHFKEQMESMKHNRT----WDLEFSLYEAKIKNLV 576
E F ++S + L E + + ++ + +L LYE + K +
Sbjct: 545 ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFI 595
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 245 bits (626), Expect = 8e-65
Identities = 183/575 (31%), Positives = 289/575 (50%), Gaps = 59/575 (10%)
Query: 10 REALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKE 69
RE LL AL +L + K+ + LRD+ P G LE VDLAE L YG +
Sbjct: 19 RELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQFYGPEP 76
Query: 70 AVKVVLKGLKVMNLLELVDQLSH-------------ICLHDYREVYREHVRCLE------ 110
A++V K LK + ++ QL + + +Y++ YREHV L
Sbjct: 77 ALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKER 136
Query: 111 EWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQE------LESVTVEALFDSGEKPSL 164
+ + R+ ++L+ P S +PE P E E ++ T LF E+
Sbjct: 137 NARSVKITKRFTKLLIA--PESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEE-GR 193
Query: 165 APSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESK-LEQLL 223
P VVLQG AG GKT A+K++ DWA G LY G+ D+ F++ C E++ ++ L L+
Sbjct: 194 RPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLI 253
Query: 224 FWCCGDNQAPVTEILRQPERLLFILDGFDELQR-----------PFEEKLKKRGLSPKES 272
C D APV ++L QP+RLLFILDG DEL PFE R L
Sbjct: 254 LDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVLGG--- 310
Query: 273 LLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEK 332
L+ + LPT LL+TTR A L+ L + + GFS++++ +YF +F DE+
Sbjct: 311 ----LLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDER 366
Query: 333 QADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTF 392
+A+RA+ V++N+ L+ C VP +CW+VC+ L+ Q+E G+ + T + +T +++ ++++
Sbjct: 367 RAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSV 426
Query: 393 L--PPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRL-AAFLSS 449
L P DG + LR+LC LA EG+ +R F E EL + L G ++ FLS
Sbjct: 427 LSSAPVADGPRLQGD----LRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSK 482
Query: 450 NDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGNDE 509
+ L + Y F SFQ+F A+SYL+++ + + + V LL + + +
Sbjct: 483 KELPGVLETEVTYQFIDQSFQEFLAALSYLLED--GGVPRTAAGGVGTLLR-GDAQPHSH 539
Query: 510 MTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQD 544
+ LT +FL + + ++E F +S + Q+
Sbjct: 540 LVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQE 574
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 226 bits (576), Expect = 5e-59
Identities = 159/543 (29%), Positives = 279/543 (51%), Gaps = 32/543 (5%)
Query: 13 LLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVK 72
L+W L +L++ +F+K K +L+ MTL + E++ +LA LLI Y E++A
Sbjct: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
Query: 73 VVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSS 132
+ L+ + M+ +L C+ +V RE + +Q A +++++ SS
Sbjct: 71 ITLRIFQKMDRKDL-------CM----KVMRERTGYTKTYQ-AHAKQKFSRLW-----SS 113
Query: 133 ESPESLACPFPEQ--ELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDW 190
+S + F E+ + E ++ LF + ++ P V++QG G GKTTL K+++ W
Sbjct: 114 KSVTEIHLYFEEEVKQEECDHLDRLF-APKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAW 172
Query: 191 ATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDG 250
+ ++ RF Y FY C+E+ L + L L+ D AP+TEI+ QPERLLF++D
Sbjct: 173 SDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDS 232
Query: 251 FDELQRPFEEK--------LKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEP 302
F+ELQ E ++KR P + LL L+R+ LP SLLI +P+ + L
Sbjct: 233 FEELQGGLNEPDSDLCGDLMEKR---PVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRD 289
Query: 303 LLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCS 362
+ + GF+E +R YF +F D K+A AF++V++++ L+ CQ+P +CW++C+
Sbjct: 290 QVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCT 349
Query: 363 WLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQ 422
L+ +M++GK + T +++T ++ ++V P+ G + ++H+ L++LCSLAAEG+
Sbjct: 350 SLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQ-LKALCSLAAEGMW 408
Query: 423 HQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKE 482
F F E +LR++ + + A L + + Y F H+ Q+F A+ YL+K
Sbjct: 409 TDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKS 468
Query: 483 DQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
R + L+ E+ FL + K L+ F F++S +
Sbjct: 469 HLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIK 528
Query: 543 QDL 545
Q +
Sbjct: 529 QQI 531
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 219 bits (557), Expect = 8e-57
Identities = 181/621 (29%), Positives = 287/621 (46%), Gaps = 52/621 (8%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L L E++ K K L L + E+E LAE+L++ E +
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
Query: 77 GLKVMNLLELVDQLSHICLHD--YREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSES 134
L+ MNL EL + D +E+ + EE E G +S
Sbjct: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKE-----GWRNSME 128
Query: 135 PESLACP--FPEQELES----VTVE-----ALFDSGEKPSLAPSLVVLQGSAGTGKTTLA 183
+SL F + ++++ VT+ + L P VVL G AG GKTTLA
Sbjct: 129 KQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLA 188
Query: 184 RKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPER 243
+K +LDW L P Y FY+SCKE+ + +L+ + Q + IL Q +R
Sbjct: 189 KKCMLDWTDCNLSP-TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQR 247
Query: 244 LLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALR 298
+LF++DG DEL+ P ++ P LL L++R LP +LL+TTRP ALR
Sbjct: 248 ILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALR 307
Query: 299 NLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICW 358
+L+ L +Q +V + GF EE+R YF +F DE QA RAF++++ N L++ P +CW
Sbjct: 308 DLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCW 367
Query: 359 VVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAA 418
+VC+ L+ QME+G+ + T T +F+ ++ + P LR+L LAA
Sbjct: 368 IVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QGAQLRGALRTLSLLAA 420
Query: 419 EGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSY 478
+G+ Q +F +L + + L FL + + K YSF H+SFQ F A+ Y
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 479 LV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCF 535
+ +E + R G +VQ+LL +E+ N ++ FL ++ + LE F
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 536 RISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVKGI------------- 579
R+SP + Q+L K + + K DL+ LYE++ + L K +
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 580 --QMNNVSFKIKHSNEKKSQS 598
++ + SF +KH + + S
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLS 621
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 219 bits (557), Expect = 8e-57
Identities = 181/621 (29%), Positives = 287/621 (46%), Gaps = 52/621 (8%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L L E++ K K L L + E+E LAE+L++ E +
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
Query: 77 GLKVMNLLELVDQLSHICLHD--YREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSES 134
L+ MNL EL + D +E+ + EE E G +S
Sbjct: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKE-----GWRNSME 128
Query: 135 PESLACP--FPEQELES----VTVE-----ALFDSGEKPSLAPSLVVLQGSAGTGKTTLA 183
+SL F + ++++ VT+ + L P VVL G AG GKTTLA
Sbjct: 129 KQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLA 188
Query: 184 RKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPER 243
+K +LDW L P Y FY+SCKE+ + +L+ + Q + IL Q +R
Sbjct: 189 KKCMLDWTDCNLSP-TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQR 247
Query: 244 LLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALR 298
+LF++DG DEL+ P ++ P LL L++R LP +LL+TTRP ALR
Sbjct: 248 ILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALR 307
Query: 299 NLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICW 358
+L+ L +Q +V + GF EE+R YF +F DE QA RAF++++ N L++ P +CW
Sbjct: 308 DLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCW 367
Query: 359 VVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAA 418
+VC+ L+ QME+G+ + T T +F+ ++ + P LR+L LAA
Sbjct: 368 IVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QGAQLRGALRTLSLLAA 420
Query: 419 EGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSY 478
+G+ Q +F +L + + L FL + + K YSF H+SFQ F A+ Y
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 479 LV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCF 535
+ +E + R G +VQ+LL +E+ N ++ FL ++ + LE F
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 536 RISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVKGI------------- 579
R+SP + Q+L K + + K DL+ LYE++ + L K +
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 580 --QMNNVSFKIKHSNEKKSQS 598
++ + SF +KH + + S
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLS 621
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 219 bits (557), Expect = 8e-57
Identities = 181/621 (29%), Positives = 287/621 (46%), Gaps = 52/621 (8%)
Query: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
L L E++ K K L L + E+E LAE+L++ E +
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
Query: 77 GLKVMNLLELVDQLSHICLHD--YREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSES 134
L+ MNL EL + D +E+ + EE E G +S
Sbjct: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKE-----GWRNSME 128
Query: 135 PESLACP--FPEQELES----VTVE-----ALFDSGEKPSLAPSLVVLQGSAGTGKTTLA 183
+SL F + ++++ VT+ + L P VVL G AG GKTTLA
Sbjct: 129 KQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLA 188
Query: 184 RKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPER 243
+K +LDW L P Y FY+SCKE+ + +L+ + Q + IL Q +R
Sbjct: 189 KKCMLDWTDCNLSP-TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQR 247
Query: 244 LLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALR 298
+LF++DG DEL+ P ++ P LL L++R LP +LL+TTRP ALR
Sbjct: 248 ILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALR 307
Query: 299 NLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICW 358
+L+ L +Q +V + GF EE+R YF +F DE QA RAF++++ N L++ P +CW
Sbjct: 308 DLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCW 367
Query: 359 VVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAA 418
+VC+ L+ QME+G+ + T T +F+ ++ + P LR+L LAA
Sbjct: 368 IVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QGAQLRGALRTLSLLAA 420
Query: 419 EGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSY 478
+G+ Q +F +L + + L FL + + K YSF H+SFQ F A+ Y
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 479 LV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCF 535
+ +E + R G +VQ+LL +E+ N ++ FL ++ + LE F
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 536 RISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVKGI------------- 579
R+SP + Q+L K + + K DL+ LYE++ + L K +
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 580 --QMNNVSFKIKHSNEKKSQS 598
++ + SF +KH + + S
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLS 621
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 206 bits (525), Expect = 4e-53
Identities = 160/574 (27%), Positives = 281/574 (48%), Gaps = 36/574 (6%)
Query: 13 LLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVK 72
LLW L +L + +F K K L+ P+ EL+ D+A+LL Y K+A +
Sbjct: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
Query: 73 VVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSS 132
V L +N +L + + + YR+H++ Q++ +
Sbjct: 71 VTLNLFLQINRKDLWTKAQEE-MRNKLNPYRKHMK------------ETFQLIWEKETCL 117
Query: 133 ESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWAT 192
PE + E + + +A + + + VVL+G G GKTTL RK++LDWA
Sbjct: 118 HVPEHFYKETMKNEYKELN-DAYTAAARRHT-----VVLEGPDGIGKTTLLRKVMLDWAE 171
Query: 193 GTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFD 252
G L+ RF +VF+++ E+ + E+ L +LL ++ + +I QPER+LFI+DGF+
Sbjct: 172 GNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFE 231
Query: 253 ELQRPFEEKLKK------RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQ 306
+L+ F +LK R P +L L+++ LP SLLI LA++ +L+
Sbjct: 232 QLK--FNLQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRH 289
Query: 307 ARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQG 366
+ + +LGFSE E+ YFS +F ++ +A + F+ V+ N L+ C P CW+VC+ ++
Sbjct: 290 PKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQ 349
Query: 367 QMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRF 426
++ERG+ + +N+T ++ ++++T +++R R L+SLC+LAAEGI F
Sbjct: 350 RLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRAR-LKSLCALAAEGIWTYTF 408
Query: 427 LFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSR 486
+F +LR++ L ++ Q ++F H+ Q+F AM YL+K +
Sbjct: 409 VFSHGDLRRNGLSESEGVMWVGMRLLQ---RRGDCFAFMHLCIQEFCAAMFYLLKRPKDD 465
Query: 487 LGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLK 546
+ + +L+ + +T F+ IS ++ S LE F F +S L Q++
Sbjct: 466 -PNPAIGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEIT 524
Query: 547 HFKEQMESMKHNRT----WDLEFSLYEAKIKNLV 576
E + + +R +L L+E + K V
Sbjct: 525 QCLESLSQCEADREAIAFQELFIGLFETQEKEFV 558
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 202 bits (515), Expect = 6e-52
Identities = 148/465 (31%), Positives = 234/465 (50%), Gaps = 36/465 (7%)
Query: 169 VVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCG 228
VVL G AG GKTTLA+K++LDWA L +F Y FY+SC+E+ L +L+F
Sbjct: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
Query: 229 DNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTL 283
+ Q + IL Q ++LF++DGFDEL ++ P LL L+ R L
Sbjct: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
Query: 284 PTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQK 343
P +LL+TTRP ALR+L L ++ ++ + GF EE+R YF +F DE QA RAF++++
Sbjct: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
Query: 344 NDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSE 403
N L++ P +CW+VC+ L+ QME+G+ + T T +F+ ++ + P
Sbjct: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QG 440
Query: 404 LSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYS 463
LR+L LAA+G+ Q + +L + + L FL + + K YS
Sbjct: 441 AQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYS 500
Query: 464 FRHISFQDFFHAMSYLV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDI 520
F H+SFQ F A+ Y + +E++ R G +VQ+LL E+ N ++ + +
Sbjct: 501 FIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGL 560
Query: 521 SKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVK 577
+ + LE F R+SP + Q+L + H+ DL+ LYE++ + LVK
Sbjct: 561 ANEKRAKELEATFGCRMSPDIKQELLRCDISCKG-GHSTVTDLQELLGCLYESQEEELVK 619
Query: 578 ---------GIQMNNV-----SFKIKHSNEKKSQSQNLFSVKSSL 608
+ +N V SF +KH + Q +L +K +L
Sbjct: 620 EVMAQFKEISLHLNAVDVVPSSFCVKHC--RNLQKMSLQVIKENL 662
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 183 bits (464), Expect = 5e-46
Identities = 130/468 (27%), Positives = 221/468 (47%), Gaps = 31/468 (6%)
Query: 97 DYREVYREHVRC--LEEWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEA 154
D+R YRE+++ LE W + + +K E + L P
Sbjct: 175 DHRRKYRENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDP------------- 221
Query: 155 LFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLL 214
+ +VL G AG GKTTLA + +L WA G L+ RF YVFY+SC ++ +
Sbjct: 222 -----NRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYM 276
Query: 215 LESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE--LQRPFEEKLKKRGLS---- 268
E+ +L+ D AP+ E + QPE+LLFI+DGF+E + E L
Sbjct: 277 KETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWY 336
Query: 269 ---PKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
P +LH L+++ +P +LLIT + +R+L+ L V I GF+ ++ YF
Sbjct: 337 QELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFM 396
Query: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
+F D + ++ ++KN+ L+ +C P +CW VCS L+ R + + +T ++
Sbjct: 397 RHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLY 456
Query: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
AY + L + ++ S R+LCSLA EG+ F F + + L+ P + +
Sbjct: 457 -AYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDS 515
Query: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR-REVQRLLEVKEQ 504
N Q +F H+SFQ+FF AMS++++E + ++ +E++ LL+
Sbjct: 516 LYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLL 575
Query: 505 EGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQM 552
+ T + F + K+ LE +ISP + ++L + E++
Sbjct: 576 DKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEEL 623
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 181 bits (458), Expect = 2e-45
Identities = 101/320 (31%), Positives = 175/320 (54%), Gaps = 6/320 (1%)
Query: 166 PSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFW 225
P V +QG+ G GKT LA+K++ +WA Y + FY C+EV + +L+
Sbjct: 203 PKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQ 262
Query: 226 CCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRR 280
+Q V++I+ +P++LL +LDGF+EL ++L+ R P LL L+ +
Sbjct: 263 KWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSK 322
Query: 281 HTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDI 340
LP +LLI R + + +PLLK V + GF+ E+ +YF YF ++ D+
Sbjct: 323 TMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSF 382
Query: 341 VQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGG 400
+N IL+ C+VP +CW+VCS L+ QMERG + ++ N+T +F+ Y+S+ P +
Sbjct: 383 AMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENF 442
Query: 401 CSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKK 460
++ + + L LC LAA+ + H++++ + +L + LD + AFL + + +
Sbjct: 443 SRKIHQAQ-LEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEED 501
Query: 461 FYSFRHISFQDFFHAMSYLV 480
Y F ++FQ+FF A+ Y++
Sbjct: 502 HYVFTLVTFQEFFAALFYVL 521
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 173 bits (438), Expect = 5e-43
Identities = 132/453 (29%), Positives = 213/453 (47%), Gaps = 16/453 (3%)
Query: 136 ESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTL 195
E+ A +PE + T+ FDS ++ P VVL G +G GK+ LAR++VL WA G L
Sbjct: 254 ENTAADWPEMQ----TLAGAFDS-DRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGL 308
Query: 196 YPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQ 255
Y G F YVF++ +E+ ES + + + D+QAPVTEI+ +PERLLFI+DGFD+L
Sbjct: 309 YQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLG 368
Query: 256 RPFEEKLKK----RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVH 311
K P +L+ L+R+ LP L++T R + L+ + R++
Sbjct: 369 SVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLL 428
Query: 312 ILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERG 371
+ G S E+R E Q + + N L CQVP + ++C LQ Q G
Sbjct: 429 VRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVG 488
Query: 372 KVVLETPRNSTDIFMAYVSTFLPPDD-DGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430
+ V + T + A+V L P C L VL+ C +A EG+ +++ +F+
Sbjct: 489 ESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDG 548
Query: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVK--EDQSRLG 488
+L L L A N +++Y+F H+S QDF A+ Y+++ E + L
Sbjct: 549 DDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALC 608
Query: 489 KESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHF 548
+ +R +E+K+ + +FL + +D LE+ + + Q L H+
Sbjct: 609 PLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHW 668
Query: 549 ----KEQMESMKHNRTWDLEFSLYEAKIKNLVK 577
+Q + T D L+E + K V+
Sbjct: 669 VSLLGQQPNATTPGDTLDAFHCLFETQDKEFVR 701
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 144 bits (363), Expect = 3e-34
Identities = 116/443 (26%), Positives = 200/443 (45%), Gaps = 28/443 (6%)
Query: 152 VEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEV 211
++ +DS S V L G +GKT + VL W G ++ YV +++ E+
Sbjct: 132 LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191
Query: 212 VLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKKRGLS--- 268
+ S L +L+ D QAP+ +IL P++LLFIL+ D ++ FE + + L
Sbjct: 192 NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIR--FELNVNESALCSNS 249
Query: 269 ----PKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYF 324
P LL L++R P C LI++RP N++ LK+ L S +R YF
Sbjct: 250 TQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYF 309
Query: 325 SSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDI 384
+S+F D ++A A +V +++IL C+V +CW+ C+ L+ QM++G+ + TD+
Sbjct: 310 NSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDL 369
Query: 385 FMAYVSTFLPPDDDGGCSELSRH-RVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRL 443
+++ L + G + H +L+ LC LAA G+ F +LR +
Sbjct: 370 HAHFLADAL--TSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADV 427
Query: 444 AAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKE 503
+ ++N K Y F H++ Q+F A+++L+ + SR E KE
Sbjct: 428 SVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVPNYLIPSGSR-------EYKE 480
Query: 504 -QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPC------LAQDLKHFKEQMESMK 556
+E + F+ + + LE F +++ +KH E +
Sbjct: 481 KREQYSDFNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLT 540
Query: 557 HNRTWDLEFSLYEAKIKNLVKGI 579
H+ L + LYE + + VK I
Sbjct: 541 HH--MPLFYCLYENREEEFVKTI 561
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 104 bits (260), Expect = 2e-22
Identities = 124/461 (26%), Positives = 205/461 (44%), Gaps = 76/461 (16%)
Query: 53 IPVDLAELLISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEW 112
+PV LA L + +K K+ L D +CL D +Y E+V LE W
Sbjct: 206 LPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAETLCLED---IYTENV--LEVW 260
Query: 113 QEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQ 172
+ G+ G P +SP +L +E LF + + V++
Sbjct: 261 ADVGMAG----------PPQKSPATLG------------LEELFSTPGHLNDDADTVLVV 298
Query: 173 GSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLES-KLEQLLF-WCCGDN 230
G AG+GK+TL +++ L WA G + F +VF SC+++ + + + LLF CC +
Sbjct: 299 GEAGSGKSTLLQRLHLLWAAGQDFQ-EFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPD 357
Query: 231 --QAPVTE-ILRQPERLLFILDGFDELQRPFEEKLKKRGLSPK-----ESLLHLLIRRHT 282
Q + + +L P+R+L DGFDE + F + ++R SP ++LL L++ +
Sbjct: 358 VGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTD--RERHCSPTDPTSVQTLLFNLLQGNL 415
Query: 283 LPTCSLLITTRPLALRNLEPLLKQAR-HVHILGFSEEERARYFSSYFTDEKQADRAFDIV 341
L ++T+RP A+ L K R ++ GFSE+ Y + ADR ++
Sbjct: 416 LKNARKVVTSRPAAVSAF--LRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLL 473
Query: 342 QKNDILYKACQVPGICWVVCSWLQGQMERGKVVLE--TPRNSTDIFMAYVSTFL----PP 395
Q+ L+ C +P V SW+ + + ++ E +P+ +TD+++ + FL PP
Sbjct: 474 QETSALHGLCHLP-----VFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPP 528
Query: 396 D--DDGGCSELSRHRV--LRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSND 451
D G L R R+ L L LA G+ ++F +L+ AA +S +D
Sbjct: 529 DSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQ---------AAQVSPDD 579
Query: 452 YQLGLAIKKF---------YSFRHISFQDFFHAMSYLVKED 483
LG ++ F HI+FQ FF A + D
Sbjct: 580 ISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSAD 620
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 91.3 bits (225), Expect = 3e-18
Identities = 95/369 (25%), Positives = 158/369 (42%), Gaps = 40/369 (10%)
Query: 124 VLLVAKPSSESPE-SLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTL 182
+L A S ++PE ++ ++ V++ LF++ + + P + VL G AG GKTTL
Sbjct: 180 ILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNT--RVNKGPRVTVLLGKAGMGKTTL 237
Query: 183 ARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKL-EQLLFWCC----GDNQAPVTEI 237
A ++ WA G L F +F +++ L+ +LLF D+ +
Sbjct: 238 AHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYL 295
Query: 238 LRQPERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLAL 297
+ +++L I DG DE +P + G P +L L LP C ++ T+RP L
Sbjct: 296 EKNADQVLLIFDGLDEALQP----MGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKL 351
Query: 298 RNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGIC 357
P +A VH+LGF Y + +F+ + + A +Q N L C VP +C
Sbjct: 352 PACLPA--EAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALC 409
Query: 358 WVVCSWLQGQM---ERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLC 414
V C L + G+ V P N T ++M V PP S L L
Sbjct: 410 QVACLCLHHLLPDHAPGQSVALLP-NMTQLYMQMVLALSPPGHLPTSS-------LLDLG 461
Query: 415 SLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAI-------KKFYSFRHI 467
+A G++ + +F ++ P L AF +++ + + Y+F H+
Sbjct: 462 EVALRGLETGKVIFYAKDI------APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHL 515
Query: 468 SFQDFFHAM 476
S Q+F A+
Sbjct: 516 SLQEFLAAL 524
>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
Length = 975
Score = 82.8 bits (203), Expect = 9e-16
Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 57/305 (18%)
Query: 169 VVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLL--LESKLEQLLFWC 226
VVL G+ GTGK+TL RKMVLDW G L F+ + SC+++ L + L QL+
Sbjct: 162 VVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLV--- 216
Query: 227 CGDNQAPVTEIL----RQPERLLFILDGFDELQRPFEEKLKKRGL--SPKE-----SLLH 275
P+ E+L LLF+L G + L F +L GL P+E +++
Sbjct: 217 -AQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDF--RLAGTGLCSDPEEPQEPAAIIV 273
Query: 276 LLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYF----------- 324
L+R++ LP S+L+TTRP A+ + P R+ I GFS+ + +
Sbjct: 274 NLLRKYMLPQASILVTTRPSAIGRI-PSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCG 332
Query: 325 -----SSYFTDEKQADRAFDIVQKN----DILYKACQVPGICWVVCSWLQGQMERGKVVL 375
S Q D ++ +N + AC +P CW+VC+ L L
Sbjct: 333 YAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLH--------FL 384
Query: 376 ETPRNSTDIFMAYVSTFLPPD------DDGGCSELS-RHRVLRSLCSLAAEGIQHQRFLF 428
P + + ++FL + D S LS R++ LA EG+ ++ F
Sbjct: 385 HAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYF 444
Query: 429 EEAEL 433
E ++
Sbjct: 445 SEEDV 449
>gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]
Length = 921
Score = 82.8 bits (203), Expect = 9e-16
Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 57/305 (18%)
Query: 169 VVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLL--LESKLEQLLFWC 226
VVL G+ GTGK+TL RKMVLDW G L F+ + SC+++ L + L QL+
Sbjct: 162 VVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLV--- 216
Query: 227 CGDNQAPVTEIL----RQPERLLFILDGFDELQRPFEEKLKKRGL--SPKE-----SLLH 275
P+ E+L LLF+L G + L F +L GL P+E +++
Sbjct: 217 -AQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDF--RLAGTGLCSDPEEPQEPAAIIV 273
Query: 276 LLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYF----------- 324
L+R++ LP S+L+TTRP A+ + P R+ I GFS+ + +
Sbjct: 274 NLLRKYMLPQASILVTTRPSAIGRI-PSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCG 332
Query: 325 -----SSYFTDEKQADRAFDIVQKN----DILYKACQVPGICWVVCSWLQGQMERGKVVL 375
S Q D ++ +N + AC +P CW+VC+ L L
Sbjct: 333 YAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLH--------FL 384
Query: 376 ETPRNSTDIFMAYVSTFLPPD------DDGGCSELS-RHRVLRSLCSLAAEGIQHQRFLF 428
P + + ++FL + D S LS R++ LA EG+ ++ F
Sbjct: 385 HAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYF 444
Query: 429 EEAEL 433
E ++
Sbjct: 445 SEEDV 449
>gi|156938336 class II transactivator [Homo sapiens]
Length = 1130
Score = 78.6 bits (192), Expect = 2e-14
Identities = 89/316 (28%), Positives = 143/316 (45%), Gaps = 27/316 (8%)
Query: 113 QEAGVNGRYNQVLLVA----KPSSESPE-SLACP-FPEQEL-ESVTVEALFDSGE--KPS 163
+ AG +G +V LV + SS+S E LA P + E++L + E L + E +P
Sbjct: 352 EPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPR 411
Query: 164 LAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLL 223
+ VL G AG GK+ A + WA G L ++D+VF V C + ++ Q L
Sbjct: 412 ETRVIAVL-GKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNRPGDAYGLQDL 468
Query: 224 FWCCGDNQAPVTE-----ILRQPERLLFILDGFDELQRPFEEKLKKRGLSPKE-----SL 273
+ G + IL++P+R+L ILDGF+EL+ G +P E L
Sbjct: 469 LFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGL 528
Query: 274 LHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDE-- 331
L L ++ L C+LL+T RP R ++ L K + GFS E+ Y YF
Sbjct: 529 LAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGM 587
Query: 332 -KQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVS 390
+ DRA +++ +L P +C VC + +E G+ + P T +++ +
Sbjct: 588 TEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA-KLPSTLTGLYVGLLG 646
Query: 391 TFLPPDDDGGCSELSR 406
G +EL++
Sbjct: 647 RAALDSPPGALAELAK 662
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 78.6 bits (192), Expect = 2e-14
Identities = 97/357 (27%), Positives = 150/357 (42%), Gaps = 37/357 (10%)
Query: 149 SVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSC 208
+V ++ LF + S+ P + + G AG GKTTL R V WA G + F V ++
Sbjct: 121 TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD-FSLVLPLTF 179
Query: 209 KEV---VLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKKR 265
+++ L +L +F G+ V P R L ILDG DE + P +
Sbjct: 180 RDLNTHEKLCADRLICSVFPHVGEPSLAVA----VPARALLILDGLDECRTPLDFSNTVA 235
Query: 266 GLSPK-----ESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEER 320
PK + L+ +IR + P S+ IT+RP A + L R I GF+EEE
Sbjct: 236 CTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVD-RMTEIRGFNEEEI 294
Query: 321 ARYFSSYF-TDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGK-----VV 374
F D+ VQ + LY C VP C + L G + R +
Sbjct: 295 KVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMAL-GHLWRSRTGPQDAE 353
Query: 375 LETPRNSTDIFMAYVSTFLPPD--DDGGCS---ELSRH---RVLRSLCSLAAEGIQHQRF 426
L PR +++ Y L + + G S E H +++ +L LA G+ +++
Sbjct: 354 LWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKY 413
Query: 427 LFEEAELRKHNLD-----GPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSY 478
+F E +++ +D G + FL + LA Y F H+S Q+F A Y
Sbjct: 414 VFYEQDMKAFGVDLALLQGAPCSCFLQREE---TLASSVAYCFTHLSLQEFVAAAYY 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,410,726
Number of Sequences: 37866
Number of extensions: 1161295
Number of successful extensions: 3613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 3434
Number of HSP's gapped (non-prelim): 100
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.