Search of human proteins with 28559088

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
         (3122 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa...  6521   0.0  
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s...  6508   0.0  
gi|38788416 laminin, alpha 1 precursor [Homo sapiens]                2855   0.0  
gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]          644   0.0  
gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]         624   e-178
gi|145309326 laminin, gamma 1 precursor [Homo sapiens]                620   e-177
gi|110611156 laminin, gamma 3 precursor [Homo sapiens]                590   e-168
gi|21264602 laminin alpha 5 [Homo sapiens]                            469   e-131
gi|38045908 laminin alpha 3 subunit isoform 2 [Homo sapiens]          430   e-119
gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]      421   e-117
gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]      421   e-117
gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]      418   e-116
gi|189217428 laminin alpha 3 subunit isoform 4 [Homo sapiens]         410   e-113
gi|119703755 laminin, beta 2 precursor [Homo sapiens]                 404   e-112
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            358   4e-98
gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]      312   4e-84
gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]      312   4e-84
gi|167614504 laminin, beta 1 precursor [Homo sapiens]                 306   3e-82
gi|219842266 usherin isoform B [Homo sapiens]                         275   4e-73
gi|219842259 usherin isoform A [Homo sapiens]                         275   4e-73
gi|143770880 laminin, beta 4 [Homo sapiens]                           262   3e-69
gi|148613884 netrin 1 [Homo sapiens]                                  246   3e-64
gi|93204871 netrin 4 [Homo sapiens]                                   209   3e-53
gi|62868217 laminin, beta 3 precursor [Homo sapiens]                  200   2e-50
gi|62868215 laminin, beta 3 precursor [Homo sapiens]                  200   2e-50
gi|189083719 laminin, beta 3 precursor [Homo sapiens]                 200   2e-50
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               194   9e-49
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]              183   3e-45
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]               181   8e-45
gi|164414431 netrin G1 isoform 1 [Homo sapiens]                       169   3e-41

>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
            sapiens]
          Length = 3122

 Score = 6521 bits (16917), Expect = 0.0
 Identities = 3122/3122 (100%), Positives = 3122/3122 (100%)

Query: 1    MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGE 60
            MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGE
Sbjct: 1    MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGE 60

Query: 61   KGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIE 120
            KGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIE
Sbjct: 61   KGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIE 120

Query: 121  YHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY 180
            YHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY
Sbjct: 121  YHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY 180

Query: 181  NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARY 240
            NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARY
Sbjct: 181  NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARY 240

Query: 241  IRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDP 300
            IRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDP
Sbjct: 241  IRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDP 300

Query: 301  ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
            ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA
Sbjct: 301  ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360

Query: 361  RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIG 420
            RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIG
Sbjct: 361  RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIG 420

Query: 421  SLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNED 480
            SLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNED
Sbjct: 421  SLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNED 480

Query: 481  PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM 540
            PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM
Sbjct: 481  PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM 540

Query: 541  SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGG 600
            SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGG
Sbjct: 541  SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGG 600

Query: 601  QLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESF 660
            QLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESF
Sbjct: 601  QLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESF 660

Query: 661  TIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA 720
            TIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA
Sbjct: 661  TIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA 720

Query: 721  VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHT 780
            VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHT
Sbjct: 721  VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHT 780

Query: 781  GGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT 840
            GGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT
Sbjct: 781  GGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT 840

Query: 841  GPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL 900
            GPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL
Sbjct: 841  GPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL 900

Query: 901  CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS 960
            CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS
Sbjct: 901  CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS 960

Query: 961  ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG 1020
            ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG
Sbjct: 961  ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG 1020

Query: 1021 NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN 1080
            NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN
Sbjct: 1021 NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN 1080

Query: 1081 CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNV 1140
            CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNV
Sbjct: 1081 CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNV 1140

Query: 1141 EGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDE 1200
            EGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDE
Sbjct: 1141 EGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDE 1200

Query: 1201 ALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE 1260
            ALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE
Sbjct: 1201 ALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE 1260

Query: 1261 AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRV 1320
            AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRV
Sbjct: 1261 AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRV 1320

Query: 1321 HRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKC 1380
            HRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKC
Sbjct: 1321 HRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKC 1380

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQ 1440
            DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQ
Sbjct: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQ 1440

Query: 1441 HHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG 1500
            HHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG
Sbjct: 1441 HHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG 1500

Query: 1501 YEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
            YEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC
Sbjct: 1501 YEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560

Query: 1561 KHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELK 1620
            KHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELK
Sbjct: 1561 KHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELK 1620

Query: 1621 HLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGE 1680
            HLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGE
Sbjct: 1621 HLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGE 1680

Query: 1681 FIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIA 1740
            FIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIA
Sbjct: 1681 FIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIA 1740

Query: 1741 EDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA 1800
            EDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA
Sbjct: 1741 EDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA 1800

Query: 1801 NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ 1860
            NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ
Sbjct: 1801 NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ 1860

Query: 1861 TKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFN 1920
            TKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFN
Sbjct: 1861 TKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFN 1920

Query: 1921 ATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNE 1980
            ATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNE
Sbjct: 1921 ATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNE 1980

Query: 1981 AKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDK 2040
            AKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDK
Sbjct: 1981 AKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDK 2040

Query: 2041 ARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK 2100
            ARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK
Sbjct: 2041 ARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK 2100

Query: 2101 NLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKP 2160
            NLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKP
Sbjct: 2101 NLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKP 2160

Query: 2161 EIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYP 2220
            EIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYP
Sbjct: 2161 EIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYP 2220

Query: 2221 DLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLF 2280
            DLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLF
Sbjct: 2221 DLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLF 2280

Query: 2281 VGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGT 2340
            VGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGT
Sbjct: 2281 VGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGT 2340

Query: 2341 IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKV 2400
            IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKV
Sbjct: 2341 IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKV 2400

Query: 2401 SYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL 2460
            SYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL
Sbjct: 2401 SYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL 2460

Query: 2461 DLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKG 2520
            DLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKG
Sbjct: 2461 DLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKG 2520

Query: 2521 CSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQ 2580
            CSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQ
Sbjct: 2521 CSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQ 2580

Query: 2581 TGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVD 2640
            TGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVD
Sbjct: 2581 TGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVD 2640

Query: 2641 ENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPV 2700
            ENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPV
Sbjct: 2641 ENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPV 2700

Query: 2701 SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALL 2760
            SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALL
Sbjct: 2701 SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALL 2760

Query: 2761 IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRN 2820
            IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRN
Sbjct: 2761 IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRN 2820

Query: 2821 GLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILD 2880
            GLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILD
Sbjct: 2821 GLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILD 2880

Query: 2881 VVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQR 2940
            VVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQR
Sbjct: 2881 VVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQR 2940

Query: 2941 GTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFH 3000
            GTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFH
Sbjct: 2941 GTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFH 3000

Query: 3001 VDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADT 3060
            VDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADT
Sbjct: 3001 VDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADT 3060

Query: 3061 NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCP 3120
            NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCP
Sbjct: 3061 NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCP 3120

Query: 3121 AN 3122
            AN
Sbjct: 3121 AN 3122


>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
            sapiens]
          Length = 3118

 Score = 6508 bits (16884), Expect = 0.0
 Identities = 3118/3122 (99%), Positives = 3118/3122 (99%), Gaps = 4/3122 (0%)

Query: 1    MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGE 60
            MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGE
Sbjct: 1    MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGE 60

Query: 61   KGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIE 120
            KGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIE
Sbjct: 61   KGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIE 120

Query: 121  YHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY 180
            YHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY
Sbjct: 121  YHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLY 180

Query: 181  NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARY 240
            NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARY
Sbjct: 181  NIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARY 240

Query: 241  IRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDP 300
            IRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDP
Sbjct: 241  IRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDP 300

Query: 301  ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
            ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA
Sbjct: 301  ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360

Query: 361  RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIG 420
            RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIG
Sbjct: 361  RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIG 420

Query: 421  SLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNED 480
            SLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNED
Sbjct: 421  SLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNED 480

Query: 481  PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM 540
            PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM
Sbjct: 481  PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM 540

Query: 541  SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGG 600
            SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGG
Sbjct: 541  SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGG 600

Query: 601  QLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESF 660
            QLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESF
Sbjct: 601  QLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESF 660

Query: 661  TIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA 720
            TIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA
Sbjct: 661  TIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAA 720

Query: 721  VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHT 780
            VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHT
Sbjct: 721  VEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHT 780

Query: 781  GGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT 840
            GGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT
Sbjct: 781  GGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT 840

Query: 841  GPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL 900
            GPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL
Sbjct: 841  GPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL 900

Query: 901  CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS 960
            CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS
Sbjct: 901  CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS 960

Query: 961  ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG 1020
            ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG
Sbjct: 961  ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG 1020

Query: 1021 NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN 1080
            NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN
Sbjct: 1021 NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN 1080

Query: 1081 CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNV 1140
            CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNV
Sbjct: 1081 CHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNV 1140

Query: 1141 EGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDE 1200
            EGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDE
Sbjct: 1141 EGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDE 1200

Query: 1201 ALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE 1260
            ALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE
Sbjct: 1201 ALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFE 1260

Query: 1261 AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRV 1320
            AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRV
Sbjct: 1261 AREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRV 1320

Query: 1321 HRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKC 1380
            HRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKC
Sbjct: 1321 HRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKC 1380

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQ 1440
            DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQ
Sbjct: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQ 1440

Query: 1441 HHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG 1500
            HHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG
Sbjct: 1441 HHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG 1500

Query: 1501 YEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
            YEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC
Sbjct: 1501 YEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560

Query: 1561 KHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELK 1620
            KHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELK
Sbjct: 1561 KHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELK 1620

Query: 1621 HLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGE 1680
            HLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGE
Sbjct: 1621 HLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGE 1680

Query: 1681 FIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIA 1740
            FIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIA
Sbjct: 1681 FIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIA 1740

Query: 1741 EDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA 1800
            EDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA
Sbjct: 1741 EDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA 1800

Query: 1801 NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ 1860
            NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ
Sbjct: 1801 NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ 1860

Query: 1861 TKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFN 1920
            TKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFN
Sbjct: 1861 TKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFN 1920

Query: 1921 ATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNE 1980
            ATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNE
Sbjct: 1921 ATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNE 1980

Query: 1981 AKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDK 2040
            AKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDK
Sbjct: 1981 AKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDK 2040

Query: 2041 ARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK 2100
            ARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK
Sbjct: 2041 ARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK 2100

Query: 2101 NLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKP 2160
            NLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKP
Sbjct: 2101 NLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKP 2160

Query: 2161 EIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYP 2220
            EIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYP
Sbjct: 2161 EIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYP 2220

Query: 2221 DLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLF 2280
            DLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLF
Sbjct: 2221 DLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLF 2280

Query: 2281 VGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGT 2340
            VGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGT
Sbjct: 2281 VGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGT 2340

Query: 2341 IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKV 2400
            IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKV
Sbjct: 2341 IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKV 2400

Query: 2401 SYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL 2460
            SYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL
Sbjct: 2401 SYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL 2460

Query: 2461 DLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKG 2520
            DLKADDKIYFGGLPTLRNL    RPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKG
Sbjct: 2461 DLKADDKIYFGGLPTLRNL----RPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKG 2516

Query: 2521 CSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQ 2580
            CSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQ
Sbjct: 2517 CSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQ 2576

Query: 2581 TGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVD 2640
            TGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVD
Sbjct: 2577 TGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVD 2636

Query: 2641 ENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPV 2700
            ENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPV
Sbjct: 2637 ENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPV 2696

Query: 2701 SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALL 2760
            SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALL
Sbjct: 2697 SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALL 2756

Query: 2761 IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRN 2820
            IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRN
Sbjct: 2757 IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRN 2816

Query: 2821 GLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILD 2880
            GLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILD
Sbjct: 2817 GLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILD 2876

Query: 2881 VVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQR 2940
            VVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQR
Sbjct: 2877 VVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQR 2936

Query: 2941 GTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFH 3000
            GTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFH
Sbjct: 2937 GTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFH 2996

Query: 3001 VDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADT 3060
            VDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADT
Sbjct: 2997 VDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADT 3056

Query: 3061 NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCP 3120
            NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCP
Sbjct: 3057 NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCP 3116

Query: 3121 AN 3122
            AN
Sbjct: 3117 AN 3118


>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
          Length = 3075

 Score = 2855 bits (7402), Expect = 0.0
 Identities = 1436/3135 (45%), Positives = 1988/3135 (63%), Gaps = 87/3135 (2%)

Query: 6    GVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEM 65
            GVLL+LLL      V AQ           +QRGLFPA+LNLASNA I+TNATCGEKGPEM
Sbjct: 4    GVLLVLLLC-----VAAQC----------RQRGLFPAILNLASNAHISTNATCGEKGPEM 48

Query: 66   YCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIEYHYVT 125
            +CKLVEHVPG+PVRNPQCRIC+ NS+NP +RHPI++AIDG N WWQSPSI+NG EYH+VT
Sbjct: 49   FCKLVEHVPGRPVRNPQCRICDGNSANPRERHPISHAIDGTNNWWQSPSIQNGREYHWVT 108

Query: 126  ITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPR 185
            ITLDL+QVFQ+AYVI+KAAN+PRPGNWILERSLD   + PWQY+AV+D+ECL+ YNI PR
Sbjct: 109  ITLDLRQVFQVAYVIIKAANAPRPGNWILERSLDGTTFSPWQYYAVSDSECLSRYNITPR 168

Query: 186  TGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRF 245
             GPP+Y  DDEVICTS+YS++ PLE+GEIH SLINGRPSADD SP+LLEFTSARYIRLR 
Sbjct: 169  RGPPTYRADDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDLSPKLLEFTSARYIRLRL 228

Query: 246  QRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKS 305
            QRIRTLNADLM  +H++P+E+DPIVTRRYYYS+KDISVGGMCICYGHA +CP D  T K 
Sbjct: 229  QRIRTLNADLMTLSHREPKELDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDETTKKL 288

Query: 306  RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
            +C+CEHNTCG+SC++CCPG+HQ+PWR GT  +   CEACNCH KA++CYYDE+VA++  S
Sbjct: 289  QCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKS 348

Query: 366  LNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEV 425
            LN  G++ GGGVCINC QNT GINCETC DG++RP  VSP    PC+PC+CDP+GSL+ V
Sbjct: 349  LNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSLSSV 408

Query: 426  CVKDEKHA--RRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNEDPCF 483
            C+KD+ H+    G  PG C CK G+ G  CDRC  GY  YP C +C C+ +GS +++PC 
Sbjct: 409  CIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKDYPTCVSCGCNPVGSASDEPCT 468

Query: 484  GPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMSGW 543
            GPC+CKENVEG  C RCK GF+NL+E N +GC ECFC GVS+ C S  W  G++  MSGW
Sbjct: 469  GPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCFGVSDVCSSLSWPVGQVNSMSGW 528

Query: 544  YLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLT 603
             +TDL    ++  QQD L    Q+SI+N    Q L   YYW+AP  YLGNKL A GG L 
Sbjct: 529  LVTDLISPRKIPSQQDALGGRHQVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLK 588

Query: 604  FTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIH 663
            +T+SYD+  E  D+  +    +I++GN L++ST  + + L P EE+ NV+ L  E+F   
Sbjct: 589  YTVSYDIPVETVDSNLMSHADVIIKGNGLTLSTQAEGLSLQPYEEYLNVVRLVPENFQDF 648

Query: 664  GTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEV 723
             +   + R + MTVLAN+  +L++  Y+    A++RL SV+L+ A S   D  +AA VE 
Sbjct: 649  HSKRQIDRDQLMTVLANVTHLLIRANYNSAKMALYRLESVSLDIASSNAIDLVVAADVEH 708

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGP 783
            C+CP GYTG+SCESC   + RV+G +FGGIC+PC+C GHA  C +V G C+ C  +T G 
Sbjct: 709  CECPQGYTGTSCESCLSGYYRVDGILFGGICQPCECHGHAAEC-NVHGVCIACAHNTTGV 767

Query: 784  YCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPR 843
            +C++CLPGFYGEP++GT  DCQPCACPL I SNNFSPTCHL+    ++CD C  GY+G  
Sbjct: 768  HCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAW 827

Query: 844  CERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCAD 903
            CERCA+GY+G P+VPG SC PC C+ N+D S  G CDS++G CL C   T G +CE CAD
Sbjct: 828  CERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCERCAD 887

Query: 904  GYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARG 963
            G++GDAV AKNC+ C C+  GS S VCH +TG C+C+ NV GQ+CD+C  G +GL S  G
Sbjct: 888  GFYGDAVTAKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHG 947

Query: 964  CVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNC 1023
            C PCNC+  GS S  C + GQC C PGV GK+CDRCAHG++ +Q+G CT C+C H  N C
Sbjct: 948  CRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPCDCPHTQNTC 1007

Query: 1024 DPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHP 1083
            DP+TG C+CPP+T G KC +C    WG+    GC+ACNCS VGS   +C+V TG C C  
Sbjct: 1008 DPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKS 1067

Query: 1084 KFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGI 1143
            KF G  C +CS G+ ++P C  CDC L GT    C+ E   C C ++TG C CK NV G 
Sbjct: 1068 KFGGRACDQCSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGP 1127

Query: 1144 HCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQ 1203
             C+ CR G F L A NPLGCS C+C G +  CSE +  +RT VTL ++Q +L +V ++  
Sbjct: 1128 QCNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSDQPLLRVVSQSNL 1187

Query: 1204 HTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEARE 1263
              TT+G+ +Q P+ +     +R+ +  EPFYW+LP+QF+G +LMAYGGKLKY++ F + +
Sbjct: 1188 RGTTEGVYYQAPDFLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKLKYSVAFYSLD 1247

Query: 1264 ETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRT 1323
              G S + PQV+I+GG     ++I     AP  G     E+ M E  WKY+       + 
Sbjct: 1248 GVGTSNFEPQVLIKGGR-IRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSVS--EKP 1304

Query: 1324 VTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPP----ADLIEK 1379
            VTREDF+ +L DI YILIKA+YG  ++QSRIS+ISMEV   GR      P    A L+E 
Sbjct: 1305 VTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEV---GRKAEKLHPEEEVASLLEN 1361

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGG-RTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            C CP G  G SC+ C PG++R +   G  R P P +  CVPC CN HS  CDP T  C N
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCLN 1421

Query: 1439 CQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACP 1498
            C  +TAGD C+ C  GYYG V G  +DC  CACP  S   +FSP+CV EG  D+RC AC 
Sbjct: 1422 CGDNTAGDHCDVCTSGYYGKVTGSASDCALCACP-HSPPASFSPTCVLEGDHDFRCDACL 1480

Query: 1499 RGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558
             GYEG++CERC+  Y G+P  PGGSCQ+C+C+P+GS+   CD  +G C CR GA+G +CD
Sbjct: 1481 LGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCD 1540

Query: 1559 GCKHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQE 1618
             C+  H     +CV C DEC G+LL DL  +   V+S+NLTG +P PY +L  LEN T+ 
Sbjct: 1541 ECEPRHILMETDCVSCDDECVGVLLNDLDEIGDAVLSLNLTGIIPVPYGILSNLENTTKY 1600

Query: 1619 LKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSL 1678
            L+  L  +   +    L +  L  +  E + L  + T++ A  ++  +  ER    ++ L
Sbjct: 1601 LQESLLKENMQK---DLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDL 1657

Query: 1679 GEFIKELARDAEAVNEKAIKLNETLGTRDEAF---ERNLEGLQKEIDQMIKELRRKNLET 1735
               I+ L      + EK   LN+TL   DE F      L+ +Q+    +++ ++ ++   
Sbjct: 1658 AIAIERLQMSITEIMEKT-TLNQTL---DEDFLLPNSTLQNMQQNGTSLLEIMQIRDFTQ 1713

Query: 1736 QKEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATD 1795
              + A  EL AAE LL ++++ + +   E E +++     L+ + N++  A  L+REA  
Sbjct: 1714 LHQNATLELKAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREAEA 1773

Query: 1796 KIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDY 1855
            K++E+N L  +   N+     KK  V+  +      + +G  ++D A    D +   +++
Sbjct: 1774 KMQESNHLLLMVNANLREFSDKKLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDALEH 1833

Query: 1856 VEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAK 1915
            +ED Q KL   S ++   IDDL   +  R   + V +AE HAA+    + VL   L+  +
Sbjct: 1834 LEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLVYRAEDHAAEFQRLADVLYSGLENIR 1893

Query: 1916 NISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSF 1975
            N+S NAT+A   + NI+  I+E+E++A++A     E + L+      L  + K  +Q+S 
Sbjct: 1894 NVSLNATSAAYVHYNIQSLIEESEELARDAHRTVTETSLLSES----LVSNGKAAVQRSS 1949

Query: 1976 RILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQ 2035
            R L E   L+  +      L+ L+ +         ++ R  N++L  L AIP     K  
Sbjct: 1950 RFLKEGNNLSRKLPGIALELSELRNKTNRFQENAVEITRQTNESLLILRAIPKGIRDKGA 2009

Query: 2036 AVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADA 2095
              K+ A  A+ +A   L  +  L Q L     + +++  ++ +T+ +++D +   ++  A
Sbjct: 2010 KTKELATSASQSAVSTLRDVAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLL--A 2067

Query: 2096 DATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCI 2155
               VK++E +A+ L D+LKP+K LE+NL +N+SEIK LI+QARKQA SIKV+VS+  DCI
Sbjct: 2068 GRKVKDVEIQANLLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKVAVSADRDCI 2127

Query: 2156 RTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVG 2215
            R Y+P+I   +YN + +NVKT   DNLLFYLGS+   DFLA+EMR+G+V+FLWD+GSG  
Sbjct: 2128 RAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGST 2187

Query: 2216 RVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDA 2275
            R+E+PD  IDD+ W+ I  +R G  G++SV+ +   + S    T  S SP    +LDV+ 
Sbjct: 2188 RLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKS---PTKTSKSPGTANVLDVNN 2244

Query: 2276 NAMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVE 2335
            + ++FVGGL G++KK+ AV+V  F GC+GE + + K IGLWN+ E+EG C+GC  S Q E
Sbjct: 2245 STLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGCFGSSQNE 2304

Query: 2336 DSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTD 2395
            D   +  FDG GY++V + +     ++ ++  F TFS + LL+YL +   +DF+S+EL  
Sbjct: 2305 DP--SFHFDGSGYSVVEKSLP--ATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFR 2360

Query: 2396 GHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVD-IDTNQEENIATSSS 2454
            G +KV  DLGSG  ++++++ +N+G W      R +KQ  ++++D  +T+ +E     + 
Sbjct: 2361 GRVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETP 2420

Query: 2455 GNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDY 2514
            G +  L+    D IY GGLP     S   R  V  K + GC+K++EISR+ +++L +   
Sbjct: 2421 GASSDLNRLDKDPIYVGGLPR----SRVVRRGVTTKSFVGCIKNLEISRSTFDLLRNS-- 2474

Query: 2515 VGVTKGCSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPP 2574
             GV KGC LE + +VSF K G++EL P  +   +E  ++F+T N SGIIL   GG     
Sbjct: 2475 YGVRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAALGG-DVEK 2533

Query: 2575 RRKRRQTGQAYYVILLNRGRLEVHLSTGART-MRKIVIRPEPNLFHDGREHSVHVERTRG 2633
            R  R +    ++ ++L  G +EVH++ G  T +RK ++        DG+ HS+ + R R 
Sbjct: 2534 RGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRR 2593

Query: 2634 IFTVQVDEN---RRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVIN 2690
            I TVQ+DEN      +  L   + I V  L+VGG P     S L     F GCI NL+ N
Sbjct: 2594 IITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGCIKNLIFN 2653

Query: 2691 SVPMDFARPVSFKNADIGRC---AHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLT 2747
               +DF   V  +  D+  C      KL  D + +      + PEP    AFP       
Sbjct: 2654 LELLDFNSAVGHEQVDLDTCWLSERPKLAPDAEDSK-----LLPEP---RAFPE------ 2699

Query: 2748 HGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMAR 2807
               C  ++    + G+ QFGL++NSH  + F+ + V+ +L++EL +RT A SGL++YMA 
Sbjct: 2700 --QCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAH 2757

Query: 2808 INHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGAS 2867
             N AD+A +QL  G  +F +DLG G T    P  ++DG+WH +K    K++G + VDG  
Sbjct: 2758 QNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRE 2817

Query: 2868 NRTIS-PKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPT 2926
            +  ++      +LDV G+ Y+GGLP  Y  R+IG +T+SI  C+ ++ +     D + P 
Sbjct: 2818 SPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQLDKDSPV 2877

Query: 2927 SSFHVGTCFANAQRGTYFDGTGFAKAV-GGFKVGLDLLVEFEFRTTTTTGVLLGISSQKM 2985
            S+F V  C+A AQ GTYFDG+G+A  V  G+KV  D+ +  EFRT++  GVLLGIS+ K+
Sbjct: 2878 SAFTVNRCYAVAQEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKV 2937

Query: 2986 DGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQ 3045
            D +G+E++D K++FHV+NGAGR TA Y+      LCDG+WH + ANK KHRI L VDGN 
Sbjct: 2938 DAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNA 2997

Query: 3046 VEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNF 3105
            V A+SP+  STS DTN+P++VGG+P  +KQ  L +   FRGC+R L L K + +    +F
Sbjct: 2998 VGAESPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIK-SPQVQSFDF 3056

Query: 3106 AKALELRGVQPVSCP 3120
            ++A EL GV   SCP
Sbjct: 3057 SRAFELHGVFLHSCP 3071


>gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]
          Length = 3333

 Score =  644 bits (1661), Expect = 0.0
 Identities = 591/2250 (26%), Positives = 964/2250 (42%), Gaps = 270/2250 (12%)

Query: 962  RGCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG 1020
            +G +PC C+  G+    C  E GQC CQP V G++C RCA G++ F    C  C C    
Sbjct: 1261 KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR--CKPCSCGR-- 1316

Query: 1021 NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDF---QCNVNTG 1077
              C+  TG+C CPP T+  +C  C  +++      GC+ CNCS  G+++    +C+ ++G
Sbjct: 1317 RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSG 1376

Query: 1078 QCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCK 1137
            QC C P+ +G +C  C+ G + +P C  C+C   GT+   CD  T         G C CK
Sbjct: 1377 QCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDPGT---------GACLCK 1427

Query: 1138 VNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTL------KAE 1191
             NVEG  C+ CR G F LD  N  GC+SC+CFG   QC  +      +V +       A+
Sbjct: 1428 ENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETAD 1487

Query: 1192 QTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGG 1251
            +  +P+      ++           +VA +  +   +H     W  P  + G K+ +YGG
Sbjct: 1488 RVDIPVSFNPGSNS-----------MVADLQELPATIHSAS--WVAPTSYLGDKVSSYGG 1534

Query: 1252 KLKY-AIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKE 1310
             L Y A  F    +       P V + G    H  II      P   +L    + + E  
Sbjct: 1535 YLTYQAKSFGLPGDMVLLEKKPDVQLTG---QHMSIIYEETNTPRPDRLHHGRVHVVEGN 1591

Query: 1311 WKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVA-EQGRGTT 1369
            +++          V+RE+ + +L  +  + I+  Y    ++  +SE+ +E A + G G  
Sbjct: 1592 FRHASS----RAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRI 1647

Query: 1370 MTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC 1429
                A  +E C CP  Y+G SC+ C PG+YR          G   G CVPC CNGHS+ C
Sbjct: 1648 ----ALAVEICACPPAYAGDSCQGCSPGYYRDHK-------GLYTGRCVPCNCNGHSNQC 1696

Query: 1430 DPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGL 1489
               + IC NCQH+TAG+ CERC  GYYG    +   C+ C CP    +N+F+  CV  G 
Sbjct: 1697 QDGSGICVNCQHNTAGEHCERCQEGYYG--NAVHGSCRACPCP---HTNSFATGCVVNG- 1750

Query: 1490 DDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFC--- 1546
             D RC +C  GY G  CERCAPGY G+P   GGSCQ C C+  G L   C P+TG C   
Sbjct: 1751 GDVRC-SCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLG-SCHPLTGDCINQ 1808

Query: 1547 TCRPGATGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARL-EQMVMSINLTGPLPAP 1605
              +  +   +CD C               D C   LL DLA + EQ+ +  +    L A 
Sbjct: 1809 EPKDSSPAEECDDC---------------DSCVMTLLNDLATMGEQLRLVKSQLQGLSAS 1853

Query: 1606 YKMLYGLENMTQELK----HLLSPQRAPERLIQLAEGNLNTLVTEMN---ELLTRATKVT 1658
              +L  + +M  + K     LL+ + A        EG L   +T++N   E L    +V 
Sbjct: 1854 AGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIEG-LERELTDLNQEFETLQEKAQVN 1912

Query: 1659 ADGEQT-GQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGL 1717
            +   QT   +  R    AK L   IK + R+   + +   +++ T G  +     +    
Sbjct: 1913 SRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHILLK---QISGTDGEGNNVPSGDFSRE 1969

Query: 1718 QKEIDQMIKELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLA 1777
              E  +M++ELR +N       AE +   ++ LL +++      +GEN  +   +R+ L 
Sbjct: 1970 WAEAQRMMRELRNRNFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLN 2029

Query: 1778 DYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGND 1837
            +Y+ K+ D    L+EA  + ++AN L   N++ + A++++ + + S +      L   + 
Sbjct: 2030 EYEAKLSDLRARLQEAAAQAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADS 2089

Query: 1838 ILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHA 1897
             L + N     +       E +   L    +EL+DK+ +LS+      L E   +AE HA
Sbjct: 2090 SLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVE---EAEKHA 2146

Query: 1898 AQLNDSSAVLDGILDEAK--NISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKL 1955
              L + +  L+ I   A    +   A  A  AY NI + I  AE  A  A   +  A  L
Sbjct: 2147 RSLQELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESA--L 2204

Query: 1956 ATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK-ENEDHLNGLKTRIENADARNGDL-- 2012
             T  +  L   AK     S ++LNEAK     +K E    LN L+  +     +   +  
Sbjct: 2205 QTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDT 2264

Query: 2013 -LRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNK 2071
             L TL D L  +     D  A + + K   R+AND   +VL  +  +  +++ +K  Y +
Sbjct: 2265 NLTTLRDGLHGIQR--GDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGR 2322

Query: 2072 LADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKEL---EDNLKKNIS 2128
              +   K           K + DAD +V  L  +   L  K++ I +      N+  N+ 
Sbjct: 2323 TQNEDFK-----------KALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMD 2371

Query: 2129 EIKELINQARKQANSIKVSV----SSGGDCIRTYKPEIKKGSYNNIVVNVKT-------A 2177
             I+ELI QAR  A+ + V +     SG +       E  KG Y ++ + ++         
Sbjct: 2372 RIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDLKG-YTSLSLFLQRPNSRENGG 2430

Query: 2178 VADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASR 2236
              +  + YLG+     D++ + +  G+++ ++++G     ++  D  +  S     V  R
Sbjct: 2431 TENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQV-DQILTKSETKEAVMDR 2489

Query: 2237 TGRNGTISVRALDGPKASI-----VPSTHHSTSPPGYTILDVD-ANAMLFVGGLTGKLKK 2290
                       L+  K +       P  +        T+L++D  N + +VGG     K 
Sbjct: 2490 VKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKL 2549

Query: 2291 ADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSP---QVEDSEGTIQFDGEG 2347
               +    + GC+     +   + L+NF+ K  +     V P   + E+S+    F+G G
Sbjct: 2550 PSRLSFPPYKGCIELDDLNENVLSLYNFK-KTFNLNTTEVEPCRRRKEESDKN-YFEGTG 2607

Query: 2348 YALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGS- 2406
            YA V  P + +  I T     +T     LL +    D   F+S+ + DG + V Y L S 
Sbjct: 2608 YARV--PTQPHAPIPTFGQTIQTTVDRGLLFFAENGD--RFISLNIEDGKLMVRYKLNSE 2663

Query: 2407 -----GMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLD 2461
                 G+   ++N   +  + K   + ++QK+  I+ VD+         T   G  F   
Sbjct: 2664 LPKERGVGDAINNGRDHSIQIK---IGKLQKRMWIN-VDVQN-------TIIDGEVFDF- 2711

Query: 2462 LKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGC 2521
                   Y GG+P    ++++ R  ++   + GC+K++   +    ++   D VGVTK C
Sbjct: 2712 ----STYYLGGIP----IAIRERFNISTPAFRGCMKNL---KKTSGVVRLNDTVGVTKKC 2760

Query: 2522 S--LENVYTVSFPKPG---FVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRR 2576
            S   + V + SF + G   F +L   P D   + +  F T   SGI+L            
Sbjct: 2761 SEDWKLVRSASFSRGGQLSFTDLGLPPTD-HLQASFGFQTFQPSGILL------------ 2807

Query: 2577 KRRQTGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFT 2636
               QT      + L  G +E+  S     + K      P  + DG  H V V        
Sbjct: 2808 -DHQTWTRNLQVTLEDGYIELSTSDSGSPIFK-----SPQTYMDGLLHYVSVISDNSGLR 2861

Query: 2637 VQVDE----NRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSV 2692
            + +D+    N + +++++  +    + L +GG+              FEGCI N+ +  +
Sbjct: 2862 LLIDDQLLRNSKRLKHISSSR----QSLRLGGS-------------NFEGCISNVFVQRL 2904

Query: 2693 P-----MDFARPVSFKNADIGRCAHQK----------LREDEDGAAPAEIVIQPEPVPTP 2737
                  +D       ++  +G C+  K           R ++        ++Q  PV +P
Sbjct: 2905 SLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLMLLKGSTRFNKTKTFRINQLLQDTPVASP 2964

Query: 2738 AFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEA 2797
                 +  +    C+   +     G+ QFG    SH+        +K R    ++++T +
Sbjct: 2965 R----SVKVWQDACSPLPKTQANHGALQFGDIPTSHLLFKLPQELLKPRSQFAVDMQTTS 3020

Query: 2798 ESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQ 2857
              GL+F+    N   F  + L  G   F+              K NDG+WH +      +
Sbjct: 3021 SRGLVFHTGTKN--SFMALYLSKGRLVFALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGE 3078

Query: 2858 EGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAE 2917
            +G L VDG   R  S      + +   +Y+G  P   + +     T S  GC++N  +  
Sbjct: 3079 KGRLVVDGLRAREGSLPGNSTISIRAPVYLGSPP---SGKPKSLPTNSFVGCLKNFQLDS 3135

Query: 2918 APADLEQPTSSFHVGTCFAN-AQRGTYF-DGTGFAKAVGGFKVGLDLLVEFEFRTTTTTG 2975
             P  L  P+SSF V +C     ++G YF +  G         +G +  + F  R  + TG
Sbjct: 3136 KP--LYTPSSSFGVSSCLGGPLEKGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTG 3193

Query: 2976 VLLGISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKH 3035
            +L+ I SQ    + + +   K+   +D+GAG  +          LCDGQWH V     +H
Sbjct: 3194 ILIHIGSQPGKHLCVYLEAGKVTASMDSGAGGTST--SVTPKQSLCDGQWHSVAVTIKQH 3251

Query: 3036 --RIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKL 3093
               +EL  D +    Q P P    A T +P+ +GG P +L    +     F GC+R++ +
Sbjct: 3252 ILHLELDTDSSYTAGQIPFP---PASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHV 3308

Query: 3094 TKGTGKPLEVNFAKALELRGVQPVS---CP 3120
                   + V   +ALE++G  PVS   CP
Sbjct: 3309 NH-----IPVPVTEALEVQG--PVSLNGCP 3331



 Score =  451 bits (1160), Expect = e-126
 Identities = 234/525 (44%), Positives = 304/525 (57%), Gaps = 66/525 (12%)

Query: 39  LFPAVLNLASNALITTNATCGEKGP-------EMYCKLVEHVP----GQPVRNPQCRICN 87
           L P   NLA  A I   ATCGE+GP       E+YCKLV        G  ++   C  CN
Sbjct: 47  LHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQFCDYCN 106

Query: 88  QNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSP 147
             S +P + HP+TNAIDG   WWQSP + +G +Y+ V +TLDL Q+F +AY+++K ANSP
Sbjct: 107 --SEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSP 164

Query: 148 RPGNWILERSLD-DVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKI 206
           RP  W+LERS+D    Y PWQY A +  +CL  +    R    +  +DD+V+C + YS+I
Sbjct: 165 RPDLWVLERSVDFGSTYSPWQYFAHSKVDCLKEFG---REANMAVTRDDDVLCVTEYSRI 221

Query: 207 HPLENGEIHISLINGRPSADDP--SPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPR 264
            PLENGE+ +SLINGRP A +   S  L EFT A  IRLRF R  TL   L+  A +DP 
Sbjct: 222 VPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPT 281

Query: 265 EIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPG 324
                VTRRYYYS+KDIS+GG C+C GHA  C ++      RCEC+H+TCG++CD+CC G
Sbjct: 282 -----VTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTG 336

Query: 325 FHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQN 384
           ++Q+ WR   +    ECEACNCHG A  CYYD +V R+  SLN +G Y GGGVCINC  N
Sbjct: 337 YNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHN 396

Query: 385 TAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGS--C 442
           TAG+NCE C  G++RP GV  + P  C PC CDP            +HA  G   GS  C
Sbjct: 397 TAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDP------------EHA-DGCEQGSGRC 443

Query: 443 HCKTGFGGVSCDRCARGYTGYPDC---------------------KACNCSGLGSKNE-D 480
           HCK  F G +C++CA GY  +P C                     K C+C+  G   E  
Sbjct: 444 HCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEIC 503

Query: 481 PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSN 525
              G C+C+  VEG  C  C+SGF+     ++  C  C+CS + +
Sbjct: 504 DAHGRCLCRPGVEGPRCDTCRSGFY-----SFPICQACWCSALGS 543



 Score =  333 bits (855), Expect = 1e-90
 Identities = 207/608 (34%), Positives = 292/608 (48%), Gaps = 81/608 (13%)

Query: 306  RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
            +C C+ N  G  C +C  G +  P           C+ C+C               R L 
Sbjct: 1284 QCPCQPNVIGRQCTRCATGHYGFP----------RCKPCSCG--------------RRLC 1319

Query: 366  LNIRGKYIGGGVCINCTQNTAGINCETC-TDGF-FRPKGVSPNYPRPCQPCHCDPIGSLN 423
              + G+         C   T    CE C T  F F P          C+ C+C   G++ 
Sbjct: 1320 EEMTGQ-------CRCPPRTVRPQCEVCETHSFSFHPMA-------GCEGCNCSRRGTIE 1365

Query: 424  EVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNE--DP 481
                + ++ +      G C CK    G  CDRCA G+  +P+C  CNC+  G++    DP
Sbjct: 1366 AAMPECDRDS------GQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDP 1419

Query: 482  CFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMS 541
              G C+CKENVEG +C+ C+ G F+L   N KGC  CFC GV+N+C SS+    K  DM 
Sbjct: 1420 GTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDML 1479

Query: 542  GWYL-----TDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLP 596
            GW+L      D+P  +   P  + +       +++ +   A  HS  W AP  YLG+K+ 
Sbjct: 1480 GWHLETADRVDIP--VSFNPGSNSM-------VADLQELPATIHSASWVAPTSYLGDKVS 1530

Query: 597  AVGGQLTFTI-SYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLL 655
            + GG LT+   S+ L  +    E+   +   L G  +SI   +      P   H   + +
Sbjct: 1531 SYGGYLTYQAKSFGLPGDMVLLEKKPDVQ--LTGQHMSIIYEETNTP-RPDRLHHGRVHV 1587

Query: 656  KEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDG 715
             E +F    +  PV R+E MTVL+ L  V +Q  Y F       LS V LE A S    G
Sbjct: 1588 VEGNFRHASSRAPVSREELMTVLSRLADVRIQGLY-FTETQRLTLSEVGLEEA-SDTGSG 1645

Query: 716  SIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLN 775
             IA AVE+C CPP Y G SC+ C P + R +  ++ G C PC C GH+  C D +G C+N
Sbjct: 1646 RIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVN 1705

Query: 776  CKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGC 835
            C+ +T G +C++C  G+YG    G+   C+ C CP    +N+F+  C ++   G +   C
Sbjct: 1706 CQHNTAGEHCERCQEGYYGNAVHGS---CRACPCP---HTNSFATGCVVNG--GDVRCSC 1757

Query: 836  PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP--GT 893
              GYTG +CERCA GYFG P   GGSCQPC CN N      GSC  L+G C+  +P   +
Sbjct: 1758 KAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQL---GSCHPLTGDCINQEPKDSS 1814

Query: 894  TGRYCELC 901
                C+ C
Sbjct: 1815 PAEECDDC 1822



 Score =  204 bits (518), Expect = 1e-51
 Identities = 134/440 (30%), Positives = 190/440 (43%), Gaps = 71/440 (16%)

Query: 757  CQCFGHAESCDDVTGECL---NCKDHTGGPYCDKCLPGFYGEPTKGT----SEDCQPCAC 809
            C C GHAE C+    E L    C+ HT G  CD+C  G+     +      S +C+ C C
Sbjct: 299  CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358

Query: 810  PLNIPSNNFSPTCHLDRSL---------GLICDGCPVGYTGPRCERCAEGYFGQPSVPGG 860
              +  +  + P     ++          G +C  C     G  CE+CA+GY+    VP  
Sbjct: 359  HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVD 418

Query: 861  S---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG---------- 907
            +   C PC C    D      C+  SG C  CKP   G  CE CA GY+           
Sbjct: 419  APDGCIPCSC----DPEHADGCEQGSGRCH-CKPNFHGDNCEKCAIGYYNFPFCLRIPIF 473

Query: 908  --------DAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQ 959
                    D V A + + C CN  G   E+C +  G+C CR  V+G RCD C++G +   
Sbjct: 474  PVSTPSSEDPV-AGDIKGCDCNLEGVLPEICDAH-GRCLCRPGVEGPRCDTCRSGFYSFP 531

Query: 960  SARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQ--EGGCTACEC 1016
                C  C C++ GS    C   +GQC C+PGVTG++CDRC  G ++F   +G  +AC+ 
Sbjct: 532  I---CQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSACDP 588

Query: 1017 SHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWG--HSITTGCKACNCSTVGSLDF--QC 1072
            +   N+     G C C  +  G  CS+C    W       +GC  C C   G++    +C
Sbjct: 589  AGTINS---NLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGEC 645

Query: 1073 NVNTGQCNCHPKFSGAKCTECSRGHW-----NYPRCNLCDCFLPGTDATTCDSETKKCSC 1127
                G C+C     G  C  C  G++     NY  C  C C + G  ++          C
Sbjct: 646  RQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSS---------MC 696

Query: 1128 SDQTGQCTCKVNVEGIHCDR 1147
            S  +G C C+ +V G  C R
Sbjct: 697  SGPSGVCQCREHVVGKVCQR 716



 Score =  190 bits (482), Expect = 2e-47
 Identities = 127/420 (30%), Positives = 172/420 (40%), Gaps = 77/420 (18%)

Query: 724  CQCPPGYTGSSCESCWP----RHRRVNGTIFGGICEPCQCFGHAESC---DDVT------ 770
            C+C     G +C+ C      R  R         CE C C GHA +C    DV       
Sbjct: 319  CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378

Query: 771  ---------GECLNCKDHTGGPYCDKCLPGFY---GEPTKGTSEDCQPCACPLNIPSN-- 816
                     G C+NC+ +T G  C++C  G+Y   G P     + C PC+C         
Sbjct: 379  NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAP-DGCIPCSCDPEHADGCE 437

Query: 817  NFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQP----------SVPG------G 860
              S  CH           C   + G  CE+CA GY+  P          S P       G
Sbjct: 438  QGSGRCH-----------CKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAG 486

Query: 861  SCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRC 920
              + C CN  L+  +P  CD+  G CL C+PG  G  C+ C  G++   +    CQ C C
Sbjct: 487  DIKGCDCN--LEGVLPEICDA-HGRCL-CRPGVEGPRCDTCRSGFYSFPI----CQACWC 538

Query: 921  NAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCE 980
            +A GS+   C S TGQCECR  V GQRCD+C +G +     +G     C+  G+ +    
Sbjct: 539  SALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSA-CDPAGTIN---S 594

Query: 981  ESGQCWCQPGVTGKKCDRCAHGYFNFQE---GGCTACECSHLG-----NNCDPKTGRCIC 1032
              G C C+  V G  C RC   Y+N  +    GC+ C+C   G       C    G C C
Sbjct: 595  NLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHC 654

Query: 1033 PPNTIGEKCSKCAPNTWG--HSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKC 1090
              +  G+ C  C    +    S   GC+ C C   G+L   C+  +G C C     G  C
Sbjct: 655  KSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVC 714



 Score =  189 bits (479), Expect = 5e-47
 Identities = 122/426 (28%), Positives = 173/426 (40%), Gaps = 73/426 (17%)

Query: 807  CACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGG-----S 861
            C C      N  +  C+++    L    C     G  C+RC  GY  +   P        
Sbjct: 299  CVC------NGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHE 352

Query: 862  CQPCQCNDNL-----DFSIPGSCDSLS--------GSCLICKPGTTGRYCELCADGYF-- 906
            C+ C C+ +      D  +     SL+        G C+ C+  T G  CE CA GY+  
Sbjct: 353  CEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRP 412

Query: 907  -GDAVDAKN-CQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS---- 960
             G  VDA + C PC C+     ++ C   +G+C C+ N  G  C+KC  G +        
Sbjct: 413  YGVPVDAPDGCIPCSCDP--EHADGCEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRI 470

Query: 961  --------------ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNF 1006
                          A     C+CN  G     C+  G+C C+PGV G +CD C  G+++F
Sbjct: 471  PIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSF 530

Query: 1007 QEGGCTACECSHLGNN---CDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCS 1063
                C AC CS LG+    C   TG+C C P   G++C +C    +      G  +  C 
Sbjct: 531  PI--CQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSA-CD 587

Query: 1064 TVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPR-----CNLCDCFLPGTDATTC 1118
              G++    N N G C C     G  C+ C   +WN  +     C+ C C   GT + T 
Sbjct: 588  PAGTI----NSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTG 643

Query: 1119 DSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC---FGTTTQC 1175
            +       C    G C CK +V G  CD C  G F L+  N  GC  C C      ++ C
Sbjct: 644  E-------CRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMC 696

Query: 1176 SEAKGL 1181
            S   G+
Sbjct: 697  SGPSGV 702



 Score =  137 bits (346), Expect = 1e-31
 Identities = 100/361 (27%), Positives = 141/361 (39%), Gaps = 81/361 (22%)

Query: 710  SYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI--CEPCQCFG-HAESC 766
            S  T G  A       C     G +CE C   + R  G        C PC C   HA+ C
Sbjct: 377  SLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGC 436

Query: 767  DDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCAC-PLNIPSNNFSPT---- 821
            +  +G C +CK +  G  C+KC  G+Y  P       C      P++ PS+         
Sbjct: 437  EQGSGRC-HCKPNFHGDNCEKCAIGYYNFPF------CLRIPIFPVSTPSSEDPVAGDIK 489

Query: 822  ---CHLDRSLGLICDG-----CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDF 873
               C+L+  L  ICD      C  G  GPRC+ C  G++  P      CQ C C+    +
Sbjct: 490  GCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI-----CQACWCSALGSY 544

Query: 874  SIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG-------------------------- 907
             +P  C S++G C  C+PG TG+ C+ C  G +                           
Sbjct: 545  QMP--CSSVTGQCE-CRPGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQC 601

Query: 908  -------------------DAVDAKNCQPCRCNAGGSFSEV--CHSQTGQCECRANVQGQ 946
                               D  +   C  C+C+  G+ S    C    G C C+++V G 
Sbjct: 602  KLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGD 661

Query: 947  RCDKCKAGTFGLQSAR--GCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGY 1003
             CD C+ G F L+ +   GC  C C+  G+ S  C   SG C C+  V GK C R  + Y
Sbjct: 662  SCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENNY 721

Query: 1004 F 1004
            +
Sbjct: 722  Y 722



 Score =  122 bits (305), Expect = 7e-27
 Identities = 69/219 (31%), Positives = 99/219 (45%), Gaps = 42/219 (19%)

Query: 830  LICDGCPVGYTGP------------------RCERCAEGYFGQPSVPGGSCQPCQCNDNL 871
            L C+  P G TGP                  +C RCA G++G P      C+PC C   L
Sbjct: 1264 LPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFP-----RCKPCSCGRRL 1318

Query: 872  DFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEV-- 929
                   C+ ++G C  C P T    CE+C    F     A  C+ C C+  G+      
Sbjct: 1319 -------CEEMTGQCR-CPPRTVRPQCEVCETHSFSFHPMA-GCEGCNCSRRGTIEAAMP 1369

Query: 930  -CHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWC 987
             C   +GQC C+  + G++CD+C +G +       CVPCNCN  G++   C+  +G C C
Sbjct: 1370 ECDRDSGQCRCKPRITGRQCDRCASGFYRFPE---CVPCNCNRDGTEPGVCDPGTGACLC 1426

Query: 988  QPGVTGKKCDRCAHGYFNFQEG---GCTACECSHLGNNC 1023
            +  V G +C+ C  G F+       GCT+C C  + N C
Sbjct: 1427 KENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQC 1465



 Score =  117 bits (292), Expect = 2e-25
 Identities = 71/221 (32%), Positives = 99/221 (44%), Gaps = 34/221 (15%)

Query: 756  PCQCFGHAES---CDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLN 812
            PC+C     +   C    G+C  C+ +  G  C +C  G YG P       C+PC+C   
Sbjct: 1265 PCECHPTGATGPHCSPEGGQC-PCQPNVIGRQCTRCATGHYGFPR------CKPCSCGRR 1317

Query: 813  IPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCN--DN 870
            +     +  C            CP     P+CE C    F    + G  C+ C C+    
Sbjct: 1318 L-CEEMTGQCR-----------CPPRTVRPQCEVCETHSFSFHPMAG--CEGCNCSRRGT 1363

Query: 871  LDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVC 930
            ++ ++P  CD  SG C  CKP  TGR C+ CA G++        C PC CN  G+   VC
Sbjct: 1364 IEAAMP-ECDRDSGQCR-CKPRITGRQCDRCASGFYR----FPECVPCNCNRDGTEPGVC 1417

Query: 931  HSQTGQCECRANVQGQRCDKCKAGTFGLQSA--RGCVPCNC 969
               TG C C+ NV+G  C+ C+ G+F L  A  +GC  C C
Sbjct: 1418 DPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458



 Score =  110 bits (274), Expect = 3e-23
 Identities = 61/177 (34%), Positives = 85/177 (48%), Gaps = 15/177 (8%)

Query: 831  ICDGCPVGYTGPRCERCAEGYF-GQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLIC 889
            IC  CP  Y G  C+ C+ GY+     +  G C PC CN + +      C   SG C+ C
Sbjct: 1653 IC-ACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSN-----QCQDGSGICVNC 1706

Query: 890  KPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTG--QCECRANVQGQR 947
            +  T G +CE C +GY+G+AV   +C+ C C    SF+  C    G  +C C+A   G +
Sbjct: 1707 QHNTAGEHCERCQEGYYGNAVHG-SCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQ 1765

Query: 948  CDKCKAGTFGLQSARG--CVPCNCNSFGSKSFDCEESGQCWCQ---PGVTGKKCDRC 999
            C++C  G FG     G  C PC+CNS G        +G C  Q        ++CD C
Sbjct: 1766 CERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 1822



 Score =  109 bits (272), Expect = 5e-23
 Identities = 84/298 (28%), Positives = 117/298 (39%), Gaps = 84/298 (28%)

Query: 287 CICYGHARACPLDPATNKSRCE---------------CEHNTCGDSCDQCCPGFHQK--- 328
           C C+GHA  C  DP   + +                 C+HNT G +C+QC  G+++    
Sbjct: 356 CNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGV 415

Query: 329 PWRAGTFLTKTECEA------------CNC----HG-KAEEC---YY------------- 355
           P  A        C+             C+C    HG   E+C   YY             
Sbjct: 416 PVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPV 475

Query: 356 -----DENVAR--RNLSLNIRGKYI----GGGVCINCTQNTAGINCETCTDGFFRPKGVS 404
                ++ VA   +    N+ G         G C+ C     G  C+TC  GF+      
Sbjct: 476 STPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCL-CRPGVEGPRCDTCRSGFY------ 528

Query: 405 PNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP 464
            ++P  CQ C C  +GS    C             G C C+ G  G  CDRC  G   +P
Sbjct: 529 -SFPI-CQACWCSALGSYQMPCSS---------VTGQCECRPGVTGQRCDRCLSGAYDFP 577

Query: 465 DCKACN--CSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
            C+  +  C   G+ N +   G C CK +VEG  CSRCK  ++NL ++N  GC EC C
Sbjct: 578 HCQGSSSACDPAGTINSN--LGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKC 633



 Score =  108 bits (271), Expect = 6e-23
 Identities = 64/194 (32%), Positives = 90/194 (46%), Gaps = 30/194 (15%)

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNG-HSSLCDPETSICQNC 1439
            +C    +G++CE C  G+YR    P     G     C+PC C+  H+  C+  +  C +C
Sbjct: 392  NCQHNTAGVNCEQCAKGYYRPYGVPVDAPDG-----CIPCSCDPEHADGCEQGSGRC-HC 445

Query: 1440 QHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSP--------SCVAEGLDD 1491
            + +  GD CE+CA+GYY         C +     +S+ ++  P         C  EG+  
Sbjct: 446  KPNFHGDNCEKCAIGYYNFPF-----CLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLP 500

Query: 1492 YRCTA-----CPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFC 1546
              C A     C  G EG  C+ C  G+   P      CQ C C   GS  +PC  VTG C
Sbjct: 501  EICDAHGRCLCRPGVEGPRCDTCRSGFYSFP-----ICQACWCSALGSYQMPCSSVTGQC 555

Query: 1547 TCRPGATGRKCDGC 1560
             CRPG TG++CD C
Sbjct: 556  ECRPGVTGQRCDRC 569



 Score =  100 bits (248), Expect = 3e-20
 Identities = 56/170 (32%), Positives = 79/170 (46%), Gaps = 17/170 (10%)

Query: 889  CKPGTTGRYCELCADGYFGD--AVDAKNCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQG 945
            C P   G  C+ C+ GY+ D   +    C PC CN     S  C   +G C  C+ N  G
Sbjct: 1656 CPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNG---HSNQCQDGSGICVNCQHNTAG 1712

Query: 946  QRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESG---QCWCQPGVTGKKCDRCAHG 1002
            + C++C+ G +G      C  C C    S +  C  +G   +C C+ G TG +C+RCA G
Sbjct: 1713 EHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPG 1772

Query: 1003 YFNFQE---GGCTACECSHLG--NNCDPKTGRCI---CPPNTIGEKCSKC 1044
            YF   +   G C  C C+  G   +C P TG CI      ++  E+C  C
Sbjct: 1773 YFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 1822



 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 55/196 (28%), Positives = 78/196 (39%), Gaps = 28/196 (14%)

Query: 1367 GTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHS 1426
            G+   P + +  +C+C  G +G  C+ CL G Y                      C G S
Sbjct: 542  GSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFP------------------HCQGSS 583

Query: 1427 SLCDPETSICQN-----CQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFS 1481
            S CDP  +I  N     C+ H  G  C RC L Y+ + K  P+ C +C C    + +   
Sbjct: 584  SACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTG 643

Query: 1482 PSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDP 1541
                 +G  D  C +      G  C+ C  GY     +    CQ C+CD  G+L   C  
Sbjct: 644  ECRQGDG--DCHCKS---HVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSG 698

Query: 1542 VTGFCTCRPGATGRKC 1557
             +G C CR    G+ C
Sbjct: 699  PSGVCQCREHVVGKVC 714



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 50/161 (31%), Positives = 70/161 (43%), Gaps = 22/161 (13%)

Query: 1420 CQCNGHSSLCD---PETSICQNCQHHTAGDFCERCALGY-----YGIVKGLPNDCQQCAC 1471
            C CNGH+ +C+   PE      CQHHT G+ C+RC  GY             ++C+ C C
Sbjct: 299  CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358

Query: 1472 PLISSSNNFSP-------SCVAEGL--DDYRCTACPRGYEGQYCERCAPGY---TGSPGN 1519
               +S+  + P       S   +G+      C  C     G  CE+CA GY    G P +
Sbjct: 359  HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVD 418

Query: 1520 PGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
                C  C CDP  +    C+  +G C C+P   G  C+ C
Sbjct: 419  APDGCIPCSCDPEHA--DGCEQGSGRCHCKPNFHGDNCEKC 457



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 33/133 (24%), Positives = 47/133 (35%), Gaps = 29/133 (21%)

Query: 284  GGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEA 343
            G  C   G   A   +   +  +C C+    G  CD+C  GF++ P          EC  
Sbjct: 1355 GCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFP----------ECVP 1404

Query: 344  CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGV 403
            CNC+    E    +                G G C+ C +N  G  C  C +G F    +
Sbjct: 1405 CNCNRDGTEPGVCDP---------------GTGACL-CKENVEGTECNVCREGSFH---L 1445

Query: 404  SPNYPRPCQPCHC 416
             P   + C  C C
Sbjct: 1446 DPANLKGCTSCFC 1458



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 24/80 (30%), Positives = 33/80 (41%), Gaps = 12/80 (15%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN---GHSSLCDPETSIC 1436
            C C     G SC+ C  G++ L               C  CQC+     SS+C   + +C
Sbjct: 652  CHCKSHVGGDSCDTCEDGYFALEKS--------NYFGCQGCQCDIGGALSSMCSGPSGVC 703

Query: 1437 QNCQHHTAGDFCERCALGYY 1456
            Q C+ H  G  C+R    YY
Sbjct: 704  Q-CREHVVGKVCQRPENNYY 722



 Score = 37.0 bits (84), Expect = 0.31
 Identities = 16/60 (26%), Positives = 27/60 (45%)

Query: 469  CNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQ 528
            C+ +G    +  P  G C C+ NV G  C+RC +G +         C    C  ++ +C+
Sbjct: 1268 CHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCR 1327


>gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]
          Length = 3277

 Score =  624 bits (1609), Expect = e-178
 Identities = 580/2243 (25%), Positives = 947/2243 (42%), Gaps = 312/2243 (13%)

Query: 962  RGCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG 1020
            +G +PC C+  G+    C  E GQC CQP V G++C RCA G++ F    C  C C    
Sbjct: 1261 KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR--CKPCSCGR-- 1316

Query: 1021 NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDF---QCNVNTG 1077
              C+  TG+C CPP T+  +C  C  +++      GC+ CNCS  G+++    +C+ ++G
Sbjct: 1317 RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPECDRDSG 1376

Query: 1078 QCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCK 1137
            QC C P+ +G +C  C+ G + +P C  C+C   GT+   CD  T         G C CK
Sbjct: 1377 QCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDPGT---------GACLCK 1427

Query: 1138 VNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTL------KAE 1191
             NVEG  C+ CR G F LD  N  GC+SC+CFG   QC  +      +V +       A+
Sbjct: 1428 ENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETAD 1487

Query: 1192 QTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGG 1251
            +  +P+      ++           +VA +  +   +H     W  P  + G K+ +YGG
Sbjct: 1488 RVDIPVSFNPGSNS-----------MVADLQELPATIHSAS--WVAPTSYLGDKVSSYGG 1534

Query: 1252 KLKY-AIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKE 1310
             L Y A  F    +       P V + G    H  II      P   +L    + + E  
Sbjct: 1535 YLTYQAKSFGLPGDMVLLEKKPDVQLTG---QHMSIIYEETNTPRPDRLHHGRVHVVEGN 1591

Query: 1311 WKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVA-EQGRGTT 1369
            +++          V+RE+ + +L  +  + I+  Y    ++  +SE+ +E A + G G  
Sbjct: 1592 FRHASS----RAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRI 1647

Query: 1370 MTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC 1429
                A  +E C CP  Y+G SC+ C PG+YR          G   G CVPC CNGHS+ C
Sbjct: 1648 ----ALAVEICACPPAYAGDSCQGCSPGYYRDHK-------GLYTGRCVPCNCNGHSNQC 1696

Query: 1430 DPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGL 1489
               + IC NCQH+TAG+ CERC  GYYG    +   C+ C CP    +N+F+  CV  G 
Sbjct: 1697 QDGSGICVNCQHNTAGEHCERCQEGYYG--NAVHGSCRACPCP---HTNSFATGCVVNG- 1750

Query: 1490 DDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTC- 1548
             D RC+ C  GY G  CERCAPGY G+P   GGSCQ C C+  G L   C P+TG C   
Sbjct: 1751 GDVRCS-CKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLG-SCHPLTGDCINQ 1808

Query: 1549 --RPGATGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARL-EQMVMSINLTGPLPAP 1605
              +  +   +CD C               D C   LL DLA + EQ+ +  +    L A 
Sbjct: 1809 EPKDSSPAEECDDC---------------DSCVMTLLNDLATMGEQLRLVKSQLQGLSAS 1853

Query: 1606 YKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQT- 1664
              +L  + +M  + K L                         N+LL   + ++  G +  
Sbjct: 1854 AGLLEQMRHMETQAKDL------------------------RNQLLNYRSAISNHGSKIE 1889

Query: 1665 GQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQM 1724
            G + E T+     L +  + L   A+  + KA  LN  +    ++         KE+D  
Sbjct: 1890 GLERELTD-----LNQEFETLQEKAQVNSRKAQTLNNNVNRATQS--------AKELDVK 1936

Query: 1725 IKELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVD 1784
            IK + R                   +L +++      +GEN  +   +R+ L +Y+ K+ 
Sbjct: 1937 IKNVIRN----------------VHMLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLS 1980

Query: 1785 DAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANR 1844
            D    L+EA  + ++AN L   N++ + A++++ + + S +      L   +  L + N 
Sbjct: 1981 DLRARLQEAAAQAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNI 2040

Query: 1845 LADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSS 1904
                +       E +   L    +EL+DK+ +LS+      L E   +AE HA  L + +
Sbjct: 2041 ALQLMEKSQKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVE---EAEKHARSLQELA 2097

Query: 1905 AVLDGILDEAKNISFNATA--AFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGL 1962
              L+ I   A        A  A  AY NI + I  AE  A  A   +  A  L T  +  
Sbjct: 2098 KQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESA--LQTVIKED 2155

Query: 1963 LKEDAKGCLQKSFRILNEAKKLANDVKEN-EDHLNGLKTRIENADARNGDL---LRTLND 2018
            L   AK     S ++LNEAK     +K+     LN L+  +     +   +   L TL D
Sbjct: 2156 LPRKAKTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRD 2215

Query: 2019 TLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAK 2078
             L  +     D  A + + K   R+AND   +VL  +  +  +++ +K  Y +  +   K
Sbjct: 2216 GLHGIQR--GDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFK 2273

Query: 2079 TNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELE---DNLKKNISEIKELIN 2135
                       K + DAD +V  L  +   L  K++ I +      N+  N+  I+ELI 
Sbjct: 2274 -----------KALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQ 2322

Query: 2136 QARKQANSIKVSVSSGGDC-IRTYKP---EIKKGSYNNIVVNVKT-------AVADNLLF 2184
            QAR  A+ + V +   G   +    P   E  KG Y ++ + ++           +  + 
Sbjct: 2323 QARDAASKVAVPMRFNGKSGVEVRLPNDLEDLKG-YTSLSLFLQRPNSRENGGTENMFVM 2381

Query: 2185 YLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTI 2243
            YLG+     D++ + +  G+++ ++++G     ++  D  +  S     V  R       
Sbjct: 2382 YLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQV-DQILTKSETKEAVMDRVKFQRIY 2440

Query: 2244 SVRALDGPKASI-----VPSTHHSTSPPGYTILDVDA-NAMLFVGGLTGKLKKADAVRVI 2297
                L+  K +       P  +        T+L++D  N + +VGG     K    +   
Sbjct: 2441 QFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFP 2500

Query: 2298 TFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSP---QVEDSEGTIQFDGEGYALVSRP 2354
             + GC+     +   + L+NF+ K  +     V P   + E+S+    F+G GYA V  P
Sbjct: 2501 PYKGCIELDDLNENVLSLYNFK-KTFNLNTTEVEPCRRRKEESDKNY-FEGTGYARV--P 2556

Query: 2355 IRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGS------GM 2408
             + +  I T     +T     LL +    D   F+S+ + DG + V Y L S      G+
Sbjct: 2557 TQPHAPIPTFGQTIQTTVDRGLLFFAENGDR--FISLNIEDGKLMVRYKLNSELPKERGV 2614

Query: 2409 ASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKI 2468
               ++N   +  + K   + ++QK+  I+ VD+         T   G  F          
Sbjct: 2615 GDAINNGRDHSIQIK---IGKLQKRMWIN-VDVQN-------TIIDGEVFDFST-----Y 2658

Query: 2469 YFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLE--NV 2526
            Y GG+P    ++++ R  ++   + GC+K+++ +     ++   D VGVTK CS +   V
Sbjct: 2659 YLGGIP----IAIRERFNISTPAFRGCMKNLKKTS---GVVRLNDTVGVTKKCSEDWKLV 2711

Query: 2527 YTVSFPKPG---FVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQ 2583
             + SF + G   F +L   P D   + +  F T   SGI+L               QT  
Sbjct: 2712 RSASFSRGGQLSFTDLGLPPTD-HLQASFGFQTFQPSGILL-------------DHQTWT 2757

Query: 2584 AYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDE-- 2641
                + L  G +E+  S     + K      P  + DG  H V V        + +D+  
Sbjct: 2758 RNLQVTLEDGYIELSTSDSGSPIFK-----SPQTYMDGLLHYVSVISDNSGLRLLIDDQL 2812

Query: 2642 --NRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPM----- 2694
              N + +++++  +    + L +GG+              FEGCI N+ +  + +     
Sbjct: 2813 LRNSKRLKHISSSR----QSLRLGGSN-------------FEGCISNVFVQRLSLSPEVL 2855

Query: 2695 DFARPVSFKNADIGRCAHQK----------LREDEDGAAPAEIVIQPEPVPTPAFPTPTP 2744
            D       ++  +G C+  K           R ++        ++Q  PV +P     + 
Sbjct: 2856 DLTSNSLKRDVSLGGCSLNKPPFLMLLKGSTRFNKTKTFRINQLLQDTPVASPR----SV 2911

Query: 2745 VLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFY 2804
             +    C+   +     G+ QFG    SH+        +K R    ++++T +  GL+F+
Sbjct: 2912 KVWQDACSPLPKTQANHGALQFGDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFH 2971

Query: 2805 MARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVD 2864
                N   F  + L  G   F+              K NDG+WH +      ++G L VD
Sbjct: 2972 TGTKN--SFMALYLSKGRLVFALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVD 3029

Query: 2865 GASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQ 2924
            G   R  S      + +   +Y+G  P   + +     T S  GC++N  +   P  L  
Sbjct: 3030 GLRAREGSLPGNSTISIRAPVYLGSPP---SGKPKSLPTNSFVGCLKNFQLDSKP--LYT 3084

Query: 2925 PTSSFHVGTCFAN-AQRGTYF-DGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISS 2982
            P+SSF V +C     ++G YF +  G         +G +  + F  R  + TG+L+ I S
Sbjct: 3085 PSSSFGVSSCLGGPLEKGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGS 3144

Query: 2983 QKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKH--RIELT 3040
            Q    + + +   K+   +D+GAG  +          LCDGQWH V     +H   +EL 
Sbjct: 3145 QPGKHLCVYLEAGKVTASMDSGAGGTST--SVTPKQSLCDGQWHSVAVTIKQHILHLELD 3202

Query: 3041 VDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKP 3100
             D +    Q P P    A T +P+ +GG P +L    +     F GC+R++ +       
Sbjct: 3203 TDSSYTAGQIPFP---PASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNH----- 3254

Query: 3101 LEVNFAKALELRGVQPVS---CP 3120
            + V   +ALE++G  PVS   CP
Sbjct: 3255 IPVPVTEALEVQG--PVSLNGCP 3275



 Score =  451 bits (1160), Expect = e-126
 Identities = 234/525 (44%), Positives = 304/525 (57%), Gaps = 66/525 (12%)

Query: 39  LFPAVLNLASNALITTNATCGEKGP-------EMYCKLVEHVP----GQPVRNPQCRICN 87
           L P   NLA  A I   ATCGE+GP       E+YCKLV        G  ++   C  CN
Sbjct: 47  LHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQFCDYCN 106

Query: 88  QNSSNPNQRHPITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSP 147
             S +P + HP+TNAIDG   WWQSP + +G +Y+ V +TLDL Q+F +AY+++K ANSP
Sbjct: 107 --SEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSP 164

Query: 148 RPGNWILERSLD-DVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKI 206
           RP  W+LERS+D    Y PWQY A +  +CL  +    R    +  +DD+V+C + YS+I
Sbjct: 165 RPDLWVLERSVDFGSTYSPWQYFAHSKVDCLKEFG---REANMAVTRDDDVLCVTEYSRI 221

Query: 207 HPLENGEIHISLINGRPSADDP--SPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPR 264
            PLENGE+ +SLINGRP A +   S  L EFT A  IRLRF R  TL   L+  A +DP 
Sbjct: 222 VPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPT 281

Query: 265 EIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPG 324
                VTRRYYYS+KDIS+GG C+C GHA  C ++      RCEC+H+TCG++CD+CC G
Sbjct: 282 -----VTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTG 336

Query: 325 FHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQN 384
           ++Q+ WR   +    ECEACNCHG A  CYYD +V R+  SLN +G Y GGGVCINC  N
Sbjct: 337 YNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHN 396

Query: 385 TAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGS--C 442
           TAG+NCE C  G++RP GV  + P  C PC CDP            +HA  G   GS  C
Sbjct: 397 TAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDP------------EHA-DGCEQGSGRC 443

Query: 443 HCKTGFGGVSCDRCARGYTGYPDC---------------------KACNCSGLGSKNE-D 480
           HCK  F G +C++CA GY  +P C                     K C+C+  G   E  
Sbjct: 444 HCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEIC 503

Query: 481 PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSN 525
              G C+C+  VEG  C  C+SGF+     ++  C  C+CS + +
Sbjct: 504 DAHGRCLCRPGVEGPRCDTCRSGFY-----SFPICQACWCSALGS 543



 Score =  333 bits (855), Expect = 1e-90
 Identities = 207/608 (34%), Positives = 292/608 (48%), Gaps = 81/608 (13%)

Query: 306  RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
            +C C+ N  G  C +C  G +  P           C+ C+C               R L 
Sbjct: 1284 QCPCQPNVIGRQCTRCATGHYGFP----------RCKPCSCG--------------RRLC 1319

Query: 366  LNIRGKYIGGGVCINCTQNTAGINCETC-TDGF-FRPKGVSPNYPRPCQPCHCDPIGSLN 423
              + G+         C   T    CE C T  F F P          C+ C+C   G++ 
Sbjct: 1320 EEMTGQ-------CRCPPRTVRPQCEVCETHSFSFHPMA-------GCEGCNCSRRGTIE 1365

Query: 424  EVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNE--DP 481
                + ++ +      G C CK    G  CDRCA G+  +P+C  CNC+  G++    DP
Sbjct: 1366 AAMPECDRDS------GQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDP 1419

Query: 482  CFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMS 541
              G C+CKENVEG +C+ C+ G F+L   N KGC  CFC GV+N+C SS+    K  DM 
Sbjct: 1420 GTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDML 1479

Query: 542  GWYL-----TDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLP 596
            GW+L      D+P  +   P  + +       +++ +   A  HS  W AP  YLG+K+ 
Sbjct: 1480 GWHLETADRVDIP--VSFNPGSNSM-------VADLQELPATIHSASWVAPTSYLGDKVS 1530

Query: 597  AVGGQLTFTI-SYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLL 655
            + GG LT+   S+ L  +    E+   +   L G  +SI   +      P   H   + +
Sbjct: 1531 SYGGYLTYQAKSFGLPGDMVLLEKKPDVQ--LTGQHMSIIYEETNTP-RPDRLHHGRVHV 1587

Query: 656  KEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDG 715
             E +F    +  PV R+E MTVL+ L  V +Q  Y F       LS V LE A S    G
Sbjct: 1588 VEGNFRHASSRAPVSREELMTVLSRLADVRIQGLY-FTETQRLTLSEVGLEEA-SDTGSG 1645

Query: 716  SIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLN 775
             IA AVE+C CPP Y G SC+ C P + R +  ++ G C PC C GH+  C D +G C+N
Sbjct: 1646 RIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVN 1705

Query: 776  CKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGC 835
            C+ +T G +C++C  G+YG    G+   C+ C CP    +N+F+  C ++   G +   C
Sbjct: 1706 CQHNTAGEHCERCQEGYYGNAVHGS---CRACPCP---HTNSFATGCVVNG--GDVRCSC 1757

Query: 836  PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP--GT 893
              GYTG +CERCA GYFG P   GGSCQPC CN N      GSC  L+G C+  +P   +
Sbjct: 1758 KAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQL---GSCHPLTGDCINQEPKDSS 1814

Query: 894  TGRYCELC 901
                C+ C
Sbjct: 1815 PAEECDDC 1822



 Score =  204 bits (518), Expect = 1e-51
 Identities = 134/440 (30%), Positives = 190/440 (43%), Gaps = 71/440 (16%)

Query: 757  CQCFGHAESCDDVTGECL---NCKDHTGGPYCDKCLPGFYGEPTKGT----SEDCQPCAC 809
            C C GHAE C+    E L    C+ HT G  CD+C  G+     +      S +C+ C C
Sbjct: 299  CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358

Query: 810  PLNIPSNNFSPTCHLDRSL---------GLICDGCPVGYTGPRCERCAEGYFGQPSVPGG 860
              +  +  + P     ++          G +C  C     G  CE+CA+GY+    VP  
Sbjct: 359  HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVD 418

Query: 861  S---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG---------- 907
            +   C PC C    D      C+  SG C  CKP   G  CE CA GY+           
Sbjct: 419  APDGCIPCSC----DPEHADGCEQGSGRCH-CKPNFHGDNCEKCAIGYYNFPFCLRIPIF 473

Query: 908  --------DAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQ 959
                    D V A + + C CN  G   E+C +  G+C CR  V+G RCD C++G +   
Sbjct: 474  PVSTPSSEDPV-AGDIKGCDCNLEGVLPEICDAH-GRCLCRPGVEGPRCDTCRSGFYSFP 531

Query: 960  SARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQ--EGGCTACEC 1016
                C  C C++ GS    C   +GQC C+PGVTG++CDRC  G ++F   +G  +AC+ 
Sbjct: 532  I---CQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSACDP 588

Query: 1017 SHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWG--HSITTGCKACNCSTVGSLDF--QC 1072
            +   N+     G C C  +  G  CS+C    W       +GC  C C   G++    +C
Sbjct: 589  AGTINS---NLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGEC 645

Query: 1073 NVNTGQCNCHPKFSGAKCTECSRGHW-----NYPRCNLCDCFLPGTDATTCDSETKKCSC 1127
                G C+C     G  C  C  G++     NY  C  C C + G  ++          C
Sbjct: 646  RQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSS---------MC 696

Query: 1128 SDQTGQCTCKVNVEGIHCDR 1147
            S  +G C C+ +V G  C R
Sbjct: 697  SGPSGVCQCREHVVGKVCQR 716



 Score =  190 bits (482), Expect = 2e-47
 Identities = 127/420 (30%), Positives = 172/420 (40%), Gaps = 77/420 (18%)

Query: 724  CQCPPGYTGSSCESCWP----RHRRVNGTIFGGICEPCQCFGHAESC---DDVT------ 770
            C+C     G +C+ C      R  R         CE C C GHA +C    DV       
Sbjct: 319  CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378

Query: 771  ---------GECLNCKDHTGGPYCDKCLPGFY---GEPTKGTSEDCQPCACPLNIPSN-- 816
                     G C+NC+ +T G  C++C  G+Y   G P     + C PC+C         
Sbjct: 379  NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAP-DGCIPCSCDPEHADGCE 437

Query: 817  NFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQP----------SVPG------G 860
              S  CH           C   + G  CE+CA GY+  P          S P       G
Sbjct: 438  QGSGRCH-----------CKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAG 486

Query: 861  SCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRC 920
              + C CN  L+  +P  CD+  G CL C+PG  G  C+ C  G++   +    CQ C C
Sbjct: 487  DIKGCDCN--LEGVLPEICDA-HGRCL-CRPGVEGPRCDTCRSGFYSFPI----CQACWC 538

Query: 921  NAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCE 980
            +A GS+   C S TGQCECR  V GQRCD+C +G +     +G     C+  G+ +    
Sbjct: 539  SALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSA-CDPAGTIN---S 594

Query: 981  ESGQCWCQPGVTGKKCDRCAHGYFNFQE---GGCTACECSHLG-----NNCDPKTGRCIC 1032
              G C C+  V G  C RC   Y+N  +    GC+ C+C   G       C    G C C
Sbjct: 595  NLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHC 654

Query: 1033 PPNTIGEKCSKCAPNTWG--HSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKC 1090
              +  G+ C  C    +    S   GC+ C C   G+L   C+  +G C C     G  C
Sbjct: 655  KSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVC 714



 Score =  189 bits (479), Expect = 5e-47
 Identities = 122/426 (28%), Positives = 173/426 (40%), Gaps = 73/426 (17%)

Query: 807  CACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGG-----S 861
            C C      N  +  C+++    L    C     G  C+RC  GY  +   P        
Sbjct: 299  CVC------NGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHE 352

Query: 862  CQPCQCNDNL-----DFSIPGSCDSLS--------GSCLICKPGTTGRYCELCADGYF-- 906
            C+ C C+ +      D  +     SL+        G C+ C+  T G  CE CA GY+  
Sbjct: 353  CEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRP 412

Query: 907  -GDAVDAKN-CQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQS---- 960
             G  VDA + C PC C+     ++ C   +G+C C+ N  G  C+KC  G +        
Sbjct: 413  YGVPVDAPDGCIPCSCDP--EHADGCEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRI 470

Query: 961  --------------ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNF 1006
                          A     C+CN  G     C+  G+C C+PGV G +CD C  G+++F
Sbjct: 471  PIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSF 530

Query: 1007 QEGGCTACECSHLGNN---CDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCS 1063
                C AC CS LG+    C   TG+C C P   G++C +C    +      G  +  C 
Sbjct: 531  PI--CQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSA-CD 587

Query: 1064 TVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPR-----CNLCDCFLPGTDATTC 1118
              G++    N N G C C     G  C+ C   +WN  +     C+ C C   GT + T 
Sbjct: 588  PAGTI----NSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTG 643

Query: 1119 DSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC---FGTTTQC 1175
            +       C    G C CK +V G  CD C  G F L+  N  GC  C C      ++ C
Sbjct: 644  E-------CRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMC 696

Query: 1176 SEAKGL 1181
            S   G+
Sbjct: 697  SGPSGV 702



 Score =  137 bits (346), Expect = 1e-31
 Identities = 100/361 (27%), Positives = 141/361 (39%), Gaps = 81/361 (22%)

Query: 710  SYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI--CEPCQCFG-HAESC 766
            S  T G  A       C     G +CE C   + R  G        C PC C   HA+ C
Sbjct: 377  SLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGC 436

Query: 767  DDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCAC-PLNIPSNNFSPT---- 821
            +  +G C +CK +  G  C+KC  G+Y  P       C      P++ PS+         
Sbjct: 437  EQGSGRC-HCKPNFHGDNCEKCAIGYYNFPF------CLRIPIFPVSTPSSEDPVAGDIK 489

Query: 822  ---CHLDRSLGLICDG-----CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDF 873
               C+L+  L  ICD      C  G  GPRC+ C  G++  P      CQ C C+    +
Sbjct: 490  GCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI-----CQACWCSALGSY 544

Query: 874  SIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG-------------------------- 907
             +P  C S++G C  C+PG TG+ C+ C  G +                           
Sbjct: 545  QMP--CSSVTGQCE-CRPGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQC 601

Query: 908  -------------------DAVDAKNCQPCRCNAGGSFSEV--CHSQTGQCECRANVQGQ 946
                               D  +   C  C+C+  G+ S    C    G C C+++V G 
Sbjct: 602  KLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGD 661

Query: 947  RCDKCKAGTFGLQSAR--GCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGY 1003
             CD C+ G F L+ +   GC  C C+  G+ S  C   SG C C+  V GK C R  + Y
Sbjct: 662  SCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENNY 721

Query: 1004 F 1004
            +
Sbjct: 722  Y 722



 Score =  122 bits (305), Expect = 7e-27
 Identities = 69/219 (31%), Positives = 99/219 (45%), Gaps = 42/219 (19%)

Query: 830  LICDGCPVGYTGP------------------RCERCAEGYFGQPSVPGGSCQPCQCNDNL 871
            L C+  P G TGP                  +C RCA G++G P      C+PC C   L
Sbjct: 1264 LPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFP-----RCKPCSCGRRL 1318

Query: 872  DFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEV-- 929
                   C+ ++G C  C P T    CE+C    F     A  C+ C C+  G+      
Sbjct: 1319 -------CEEMTGQCR-CPPRTVRPQCEVCETHSFSFHPMA-GCEGCNCSRRGTIEAAMP 1369

Query: 930  -CHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWC 987
             C   +GQC C+  + G++CD+C +G +       CVPCNCN  G++   C+  +G C C
Sbjct: 1370 ECDRDSGQCRCKPRITGRQCDRCASGFYRFPE---CVPCNCNRDGTEPGVCDPGTGACLC 1426

Query: 988  QPGVTGKKCDRCAHGYFNFQEG---GCTACECSHLGNNC 1023
            +  V G +C+ C  G F+       GCT+C C  + N C
Sbjct: 1427 KENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQC 1465



 Score =  117 bits (292), Expect = 2e-25
 Identities = 71/221 (32%), Positives = 99/221 (44%), Gaps = 34/221 (15%)

Query: 756  PCQCFGHAES---CDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLN 812
            PC+C     +   C    G+C  C+ +  G  C +C  G YG P       C+PC+C   
Sbjct: 1265 PCECHPTGATGPHCSPEGGQC-PCQPNVIGRQCTRCATGHYGFPR------CKPCSCGRR 1317

Query: 813  IPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCN--DN 870
            +     +  C            CP     P+CE C    F    + G  C+ C C+    
Sbjct: 1318 L-CEEMTGQCR-----------CPPRTVRPQCEVCETHSFSFHPMAG--CEGCNCSRRGT 1363

Query: 871  LDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVC 930
            ++ ++P  CD  SG C  CKP  TGR C+ CA G++        C PC CN  G+   VC
Sbjct: 1364 IEAAMP-ECDRDSGQCR-CKPRITGRQCDRCASGFYR----FPECVPCNCNRDGTEPGVC 1417

Query: 931  HSQTGQCECRANVQGQRCDKCKAGTFGLQSA--RGCVPCNC 969
               TG C C+ NV+G  C+ C+ G+F L  A  +GC  C C
Sbjct: 1418 DPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458



 Score =  110 bits (274), Expect = 3e-23
 Identities = 61/177 (34%), Positives = 85/177 (48%), Gaps = 15/177 (8%)

Query: 831  ICDGCPVGYTGPRCERCAEGYF-GQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLIC 889
            IC  CP  Y G  C+ C+ GY+     +  G C PC CN + +      C   SG C+ C
Sbjct: 1653 IC-ACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSN-----QCQDGSGICVNC 1706

Query: 890  KPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTG--QCECRANVQGQR 947
            +  T G +CE C +GY+G+AV   +C+ C C    SF+  C    G  +C C+A   G +
Sbjct: 1707 QHNTAGEHCERCQEGYYGNAVHG-SCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQ 1765

Query: 948  CDKCKAGTFGLQSARG--CVPCNCNSFGSKSFDCEESGQCWCQ---PGVTGKKCDRC 999
            C++C  G FG     G  C PC+CNS G        +G C  Q        ++CD C
Sbjct: 1766 CERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 1822



 Score =  109 bits (272), Expect = 5e-23
 Identities = 84/298 (28%), Positives = 117/298 (39%), Gaps = 84/298 (28%)

Query: 287 CICYGHARACPLDPATNKSRCE---------------CEHNTCGDSCDQCCPGFHQK--- 328
           C C+GHA  C  DP   + +                 C+HNT G +C+QC  G+++    
Sbjct: 356 CNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGV 415

Query: 329 PWRAGTFLTKTECEA------------CNC----HG-KAEEC---YY------------- 355
           P  A        C+             C+C    HG   E+C   YY             
Sbjct: 416 PVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPV 475

Query: 356 -----DENVAR--RNLSLNIRGKYI----GGGVCINCTQNTAGINCETCTDGFFRPKGVS 404
                ++ VA   +    N+ G         G C+ C     G  C+TC  GF+      
Sbjct: 476 STPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCL-CRPGVEGPRCDTCRSGFY------ 528

Query: 405 PNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP 464
            ++P  CQ C C  +GS    C             G C C+ G  G  CDRC  G   +P
Sbjct: 529 -SFPI-CQACWCSALGSYQMPCSS---------VTGQCECRPGVTGQRCDRCLSGAYDFP 577

Query: 465 DCKACN--CSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
            C+  +  C   G+ N +   G C CK +VEG  CSRCK  ++NL ++N  GC EC C
Sbjct: 578 HCQGSSSACDPAGTINSN--LGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKC 633



 Score =  108 bits (271), Expect = 6e-23
 Identities = 64/194 (32%), Positives = 90/194 (46%), Gaps = 30/194 (15%)

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNG-HSSLCDPETSICQNC 1439
            +C    +G++CE C  G+YR    P     G     C+PC C+  H+  C+  +  C +C
Sbjct: 392  NCQHNTAGVNCEQCAKGYYRPYGVPVDAPDG-----CIPCSCDPEHADGCEQGSGRC-HC 445

Query: 1440 QHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSP--------SCVAEGLDD 1491
            + +  GD CE+CA+GYY         C +     +S+ ++  P         C  EG+  
Sbjct: 446  KPNFHGDNCEKCAIGYYNFPF-----CLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLP 500

Query: 1492 YRCTA-----CPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFC 1546
              C A     C  G EG  C+ C  G+   P      CQ C C   GS  +PC  VTG C
Sbjct: 501  EICDAHGRCLCRPGVEGPRCDTCRSGFYSFP-----ICQACWCSALGSYQMPCSSVTGQC 555

Query: 1547 TCRPGATGRKCDGC 1560
             CRPG TG++CD C
Sbjct: 556  ECRPGVTGQRCDRC 569



 Score =  100 bits (248), Expect = 3e-20
 Identities = 56/170 (32%), Positives = 79/170 (46%), Gaps = 17/170 (10%)

Query: 889  CKPGTTGRYCELCADGYFGD--AVDAKNCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQG 945
            C P   G  C+ C+ GY+ D   +    C PC CN     S  C   +G C  C+ N  G
Sbjct: 1656 CPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNG---HSNQCQDGSGICVNCQHNTAG 1712

Query: 946  QRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESG---QCWCQPGVTGKKCDRCAHG 1002
            + C++C+ G +G      C  C C    S +  C  +G   +C C+ G TG +C+RCA G
Sbjct: 1713 EHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPG 1772

Query: 1003 YFNFQE---GGCTACECSHLG--NNCDPKTGRCI---CPPNTIGEKCSKC 1044
            YF   +   G C  C C+  G   +C P TG CI      ++  E+C  C
Sbjct: 1773 YFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 1822



 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 55/196 (28%), Positives = 78/196 (39%), Gaps = 28/196 (14%)

Query: 1367 GTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHS 1426
            G+   P + +  +C+C  G +G  C+ CL G Y                      C G S
Sbjct: 542  GSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFP------------------HCQGSS 583

Query: 1427 SLCDPETSICQN-----CQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFS 1481
            S CDP  +I  N     C+ H  G  C RC L Y+ + K  P+ C +C C    + +   
Sbjct: 584  SACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTG 643

Query: 1482 PSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDP 1541
                 +G  D  C +      G  C+ C  GY     +    CQ C+CD  G+L   C  
Sbjct: 644  ECRQGDG--DCHCKS---HVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSG 698

Query: 1542 VTGFCTCRPGATGRKC 1557
             +G C CR    G+ C
Sbjct: 699  PSGVCQCREHVVGKVC 714



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 50/161 (31%), Positives = 70/161 (43%), Gaps = 22/161 (13%)

Query: 1420 CQCNGHSSLCD---PETSICQNCQHHTAGDFCERCALGY-----YGIVKGLPNDCQQCAC 1471
            C CNGH+ +C+   PE      CQHHT G+ C+RC  GY             ++C+ C C
Sbjct: 299  CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358

Query: 1472 PLISSSNNFSP-------SCVAEGL--DDYRCTACPRGYEGQYCERCAPGY---TGSPGN 1519
               +S+  + P       S   +G+      C  C     G  CE+CA GY    G P +
Sbjct: 359  HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVD 418

Query: 1520 PGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
                C  C CDP  +    C+  +G C C+P   G  C+ C
Sbjct: 419  APDGCIPCSCDPEHA--DGCEQGSGRCHCKPNFHGDNCEKC 457



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 33/133 (24%), Positives = 47/133 (35%), Gaps = 29/133 (21%)

Query: 284  GGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEA 343
            G  C   G   A   +   +  +C C+    G  CD+C  GF++ P          EC  
Sbjct: 1355 GCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFP----------ECVP 1404

Query: 344  CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGV 403
            CNC+    E    +                G G C+ C +N  G  C  C +G F    +
Sbjct: 1405 CNCNRDGTEPGVCDP---------------GTGACL-CKENVEGTECNVCREGSFH---L 1445

Query: 404  SPNYPRPCQPCHC 416
             P   + C  C C
Sbjct: 1446 DPANLKGCTSCFC 1458



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 24/80 (30%), Positives = 33/80 (41%), Gaps = 12/80 (15%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN---GHSSLCDPETSIC 1436
            C C     G SC+ C  G++ L               C  CQC+     SS+C   + +C
Sbjct: 652  CHCKSHVGGDSCDTCEDGYFALEKS--------NYFGCQGCQCDIGGALSSMCSGPSGVC 703

Query: 1437 QNCQHHTAGDFCERCALGYY 1456
            Q C+ H  G  C+R    YY
Sbjct: 704  Q-CREHVVGKVCQRPENNYY 722



 Score = 37.0 bits (84), Expect = 0.31
 Identities = 16/60 (26%), Positives = 27/60 (45%)

Query: 469  CNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQ 528
            C+ +G    +  P  G C C+ NV G  C+RC +G +         C    C  ++ +C+
Sbjct: 1268 CHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCR 1327


>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
          Length = 1609

 Score =  620 bits (1598), Expect = e-177
 Identities = 378/1086 (34%), Positives = 543/1086 (50%), Gaps = 108/1086 (9%)

Query: 9    LLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCK 68
            +L +L+       AQ    +   +  + +   P  +N A N  +    TCG   PE YC 
Sbjct: 20   VLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCV 78

Query: 69   LVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKN----TWWQSPSIKNGIEY-HY 123
                  G       C +C+  +  P+ +H      D  N    TWWQS ++  G++Y   
Sbjct: 79   QT----GVTGVTKSCHLCD--AGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSS 132

Query: 124  VTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIY 183
            + +TL L + F I YV +K   S      I +R+ +D  + P+QY++ +   C   Y+  
Sbjct: 133  INLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGS---CENTYSKA 189

Query: 184  PRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSAD--DPSPELLEFTSARYI 241
             R    +   + + +CT  +S I PL  G +  S + GRPSA   D SP L E+ +A  I
Sbjct: 190  NRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDI 249

Query: 242  RLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPA 301
            R+   R+ T   ++           DP V + YYY++ D +VGG C C GHA  C +   
Sbjct: 250  RVTLNRLNTFGDEVFN---------DPKVLKSYYYAISDFAVGGRCKCNGHASEC-MKNE 299

Query: 302  TNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVAR 361
             +K  C C+HNT G  C++C P F+ +PWR  T  + +EC  C+C+G+++ECY+D  + R
Sbjct: 300  FDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYR 359

Query: 362  RNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGS 421
                         GG C NC  NT G +CE C + FFR   +  N    C  CHC P+GS
Sbjct: 360  STGH---------GGHCTNCQDNTDGAHCERCRENFFR---LGNN--EACSSCHCSPVGS 405

Query: 422  LNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD--CKACNCSGLGSKNE 479
            L+  C           + G C CK G  G  CDRC  G+    +  C+ C+C   GS +E
Sbjct: 406  LSTQCD----------SYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE 455

Query: 480  -DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQ 538
             +   G C+CK+NVEG +C RCK GFFNL+  N +GC  CFC G S+ C ++      + 
Sbjct: 456  CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGY--SVY 513

Query: 539  DMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSY---YWSAPAPYLGNKL 595
             +S  +  D  G    A Q+D  ++  + S S  +    +  SY   Y+ APA +LG ++
Sbjct: 514  SISSTFQIDEDG--WRAEQRDGSEASLEWS-SERQDIAVISDSYFPRYFIAPAKFLGKQV 570

Query: 596  PAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSIST---AQDEVYLHPSEEHTNV 652
             + G  L+F+   D  +     E      ++LEG  L +S    AQ   Y  PSE     
Sbjct: 571  LSYGQNLSFSFRVDRRDTRLSAED-----LVLEGAGLRVSVPLIAQGNSY--PSETTVKY 623

Query: 653  LLLKEESFTIH-GTHFPVRRK----EFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLES 707
            +      F +H  T +P R      EF  +L NL  + ++ TYS    +   L  V L S
Sbjct: 624  V------FRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYS--ERSAGYLDDVTLAS 675

Query: 708  AVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFG-GICEPCQCFGHAESC 766
            A   P  G  A  VE C CP GY G  CE C   +RR    +     C  C C GH+E+C
Sbjct: 676  A--RPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETC 733

Query: 767  DDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDR 826
            D  TG C NC+D+T GP+C+KC  G+YG+ T GTS DCQPC CP        S    + +
Sbjct: 734  DPETGVC-NCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVPK 786

Query: 827  SLGLICDGCPVGYTGPRCERCAEGYFGQP---SVPGGSCQPCQCNDNLDFSIPGSCDSLS 883
            +  ++C  CP G TG RCE C +GYFG P   + P   C+ CQC+DN+D +  G+C+ L+
Sbjct: 787  TKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLT 846

Query: 884  GSCLICKPGTTGRYCELCADGYFGDAV---DAKNCQPCRCNAGGSFSE--VCHSQTGQCE 938
            G CL C   T G YC+ C DG+FG+ +    A  C+ C CN  G+  +   C+  TGQCE
Sbjct: 847  GECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCE 906

Query: 939  CRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCD 997
            C  +V GQ C  C  G + LQS +GC  C+C++ GS +  C+  +GQC CQPG+TG+ C+
Sbjct: 907  CLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCE 966

Query: 998  RCAHGYFNFQEGGCTACECSHLGN---NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSIT 1054
            RC   +F F   GC  C+C   G+    C    GRC C    +G +C +C  N + +   
Sbjct: 967  RCEVNHFGFGPEGCKPCDCHPEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSW 1025

Query: 1055 TGCKAC 1060
             GC+ C
Sbjct: 1026 PGCQEC 1031



 Score =  325 bits (834), Expect = 3e-88
 Identities = 345/1408 (24%), Positives = 558/1408 (39%), Gaps = 270/1408 (19%)

Query: 919  RCNAGGSFSEVCHSQTGQ--CECRANVQGQRCDKC---------KAGTFGLQSARGCVPC 967
            RC   G  SE   ++  +  C C+ N  G  C+KC         +  T   +SA  C+PC
Sbjct: 285  RCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRAT--AESASECLPC 342

Query: 968  NCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKT 1027
            +CN           S +C+  P +         HG      G CT C+            
Sbjct: 343  DCNG---------RSQECYFDPELYRST----GHG------GHCTNCQ------------ 371

Query: 1028 GRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSG 1087
                   NT G  C +C  N +       C +C+CS VGSL  QC+ + G+C+C P   G
Sbjct: 372  ------DNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCD-SYGRCSCKPGVMG 424

Query: 1088 AKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDR 1147
             KC  C  G  +        C        +CD       C+ +TG+C CK NVEG +C+R
Sbjct: 425  DKCDRCQPGFHSLTEAGCRPC--------SCDPSGSIDECNIETGRCVCKDNVEGFNCER 476

Query: 1148 CRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTT 1207
            C+PG F L++ NP GC+ C+CFG ++ C+ A G      ++ +  +   + ++  +    
Sbjct: 477  CKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGY-----SVYSISSTFQIDEDGWRAEQR 531

Query: 1208 KGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGF 1267
             G            D+        P Y+  P +F GK++++YG  L ++   + R +T  
Sbjct: 532  DGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVD-RRDTRL 590

Query: 1268 STYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEW--KYYGDDPRVHRTVT 1325
            S  +  +++ G            ++ PLI Q   +  E T K     +   D      +T
Sbjct: 591  SAED--LVLEGAG--------LRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALT 640

Query: 1326 REDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLG 1385
              +F  +L ++  I I+ TY        + ++++  A  G G     PA  +E C CP+G
Sbjct: 641  PFEFQKLLNNLTSIKIRGTYSE-RSAGYLDDVTLASARPGPGV----PATWVESCTCPVG 695

Query: 1386 YSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAG 1445
            Y G  CE CL G+ R     G  +P      CV C CNGHS  CDPET +C NC+ +TAG
Sbjct: 696  YGGQFCEMCLSGYRRETPNLGPYSP------CVLCACNGHSETCDPETGVC-NCRDNTAG 748

Query: 1446 DFCERCALGYYG-IVKGLPNDCQQCACP------LISSSNNFSPSCVAEGLDDYRCTACP 1498
              CE+C+ GYYG    G  +DCQ C CP      ++  +     +    G    RC  C 
Sbjct: 749  PHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCD 808

Query: 1499 RGYEGQ---------------------------------------------YCERCAPGY 1513
             GY G                                              YC+RC  G+
Sbjct: 809  DGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGF 868

Query: 1514 TGSPGNP--GGSCQECECDPYGSL--PVPCDPVTGFCTCRPGATGRKCDGCK--HWHARE 1567
             G+P  P     C+ C C+ YG++     C+PVTG C C P  TG+ C  C    ++ + 
Sbjct: 869  FGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQS 928

Query: 1568 GWECVFCGDECTGLLLGDL-ARLEQMVMSINLTGPLPAPYKMLYGLENMTQELKHLLSPQ 1626
            G  C  C     G   G    R  Q      +TG                 E+ H     
Sbjct: 929  GQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQ-----------HCERCEVNHFGFGP 977

Query: 1627 RAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNT-----RAKSLGEF 1681
               +      EG+L+    +      R   V    +Q  ++     +        +    
Sbjct: 978  EGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRL 1037

Query: 1682 IKELARDAEAVNEKAIKLNETLGTRDE-----AFERNLEGLQKEIDQMIKELRRKNLETQ 1736
            +K+   D     ++   L   LGT DE     AFE  L+  ++E+  +++E         
Sbjct: 1038 VKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLRE--------- 1088

Query: 1737 KEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDK 1796
               A+D     + L+ +++++       N  +   +  +L + +N +++  +L  +A   
Sbjct: 1089 ---AQDVKDVDQNLMDRLQRV-------NNTLSSQI-SRLQNIRNTIEETGNLAEQARAH 1137

Query: 1797 IREANRLFAVNQKNMTALEKKKEAVES-GKRQIENTLKEGNDIL--DEANRL-------A 1846
            +    RL  +  +    LEK K A  +    Q E+T    N  L  +EA +L       A
Sbjct: 1138 VENTERLIEIASRE---LEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEA 1194

Query: 1847 DEINSIIDYVEDIQTKLPPM--------------SEELNDKID---DLSQEIKDR--KLA 1887
            D+I  +     D  T+   +               EELN K +   ++SQ+++ +  ++ 
Sbjct: 1195 DDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVH 1254

Query: 1888 EKVSQAESHAAQLNDSSAVL-----DGILDEAKNISFNATAAFKAY-SNIKDYIDEAEKV 1941
            E+  +A   A ++  S A L     + + +EA NI   A    +     +KDY D  E +
Sbjct: 1255 EEAKRAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDM 1314

Query: 1942 ---AKEAKDLAHEA-TKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNG 1997
                 E K+L  +  T+  T  + L + DA   L +       AKK  + ++E  D LN 
Sbjct: 1315 RGKELEVKNLLEKGKTEQQTADQLLARADAAKALAE-----EAAKKGRDTLQEANDILNN 1369

Query: 1998 LKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITE 2057
            LK    + D R  D      + L K+ AI N T   +    +K R+A        A  TE
Sbjct: 1370 LK----DFDRRVNDNKTAAEEALRKIPAI-NQT---ITEANEKTREAQQALGSAAADATE 1421

Query: 2058 LHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIK 2117
                        NK  ++    +AV K+ +  K  A+A+ T   +    + + + LK ++
Sbjct: 1422 AK----------NKAHEAERIASAVQKNATSTK--AEAERTFAEVTDLDNEVNNMLKQLQ 1469

Query: 2118 ELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTA 2177
            E E  LK             RKQ ++ +  + +G       + EI      N V ++ + 
Sbjct: 1470 EAEKELK-------------RKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSI 1516

Query: 2178 VADNLLFYLGSAKFIDFLAIEMRKGKVS 2205
            + D LL  LG    +D   +   +G ++
Sbjct: 1517 IND-LLEQLGQLDTVDLNKLNEIEGTLN 1543



 Score =  197 bits (501), Expect = 1e-49
 Identities = 116/358 (32%), Positives = 165/358 (46%), Gaps = 44/358 (12%)

Query: 835  CPVGYTGPRCERCAEGYFGQ-PSV-PGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPG 892
            CPVGY G  CE C  GY  + P++ P   C  C CN + +     +CD  +G C  C+  
Sbjct: 692  CPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSE-----TCDPETGVCN-CRDN 745

Query: 893  TTGRYCELCADGYFGDAV--DAKNCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQGQRCD 949
            T G +CE C+DGY+GD+    + +CQPC C  G S + V  ++   C  C     G+RC+
Sbjct: 746  TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCE 805

Query: 950  KCKAGTFGLQSARG-----CVPCNC--NSFGSKSFDCEE-SGQCW-CQPGVTGKKCDRCA 1000
             C  G FG    R      C  C C  N   +   +C   +G+C  C     G  CDRC 
Sbjct: 806  LCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCK 865

Query: 1001 HGYFNFQ-----EGGCTACECSHLG-----NNCDPKTGRCICPPNTIGEKCSKCAPNTWG 1050
             G+F           C AC C+  G     ++C+P TG+C C P+  G+ C  C P  + 
Sbjct: 866  DGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYN 925

Query: 1051 HSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNY--PRCNLCDC 1108
                 GC+ C+C  +GS + QC++ TGQC C P  +G  C  C   H+ +    C  CDC
Sbjct: 926  LQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDC 985

Query: 1109 FLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSC 1166
               G+ +  C  +          G+C C+    G  CD+C    F    ++  GC  C
Sbjct: 986  HPEGSLSLQCKDD----------GRCECREGFVGNRCDQCEENYF--YNRSWPGCQEC 1031



 Score =  180 bits (456), Expect = 2e-44
 Identities = 109/319 (34%), Positives = 141/319 (44%), Gaps = 39/319 (12%)

Query: 876  PGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTG 935
            PG   +   SC  C  G  G++CE+C  GY  +  +     PC   A    SE C  +TG
Sbjct: 680  PGVPATWVESCT-CPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETG 738

Query: 936  QCECRANVQGQRCDKCKAGTFGLQSA---RGCVPCNCNSFGSKSF--DCEESGQCWCQPG 990
             C CR N  G  C+KC  G +G  +A     C PC C    S +     +E     C  G
Sbjct: 739  VCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTG 798

Query: 991  VTGKKCDRCAHGYFNFQEGG------CTACECS-----HLGNNCDPKTGRCI-CPPNTIG 1038
             TGK+C+ C  GYF    G       C  C+CS     +   NC+  TG C+ C  NT G
Sbjct: 799  TTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAG 858

Query: 1039 EKCSKCAPNTWGHSITTG----CKACNCSTVGSLDFQ--CNVNTGQCNCHPKFSGAKCTE 1092
              C +C    +G+ +       CKACNC+  G++  Q  CN  TGQC C P  +G  C  
Sbjct: 859  FYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGA 918

Query: 1093 CSRGHWNYPR---CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCR 1149
            C  G +N      C  CDC   G+    CD          +TGQC C+  + G HC+RC 
Sbjct: 919  CDPGFYNLQSGQGCERCDCHALGSTNGQCDI---------RTGQCECQPGITGQHCERCE 969

Query: 1150 PGKFGLDAKNPLGCSSCYC 1168
               FG     P GC  C C
Sbjct: 970  VNHFGF---GPEGCKPCDC 985



 Score =  134 bits (337), Expect = 1e-30
 Identities = 73/216 (33%), Positives = 97/216 (44%), Gaps = 22/216 (10%)

Query: 865  CQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGD-------AVDAKNCQP 917
            C+CN +    +    D L  +C   K  T G  CE C   +F D       A  A  C P
Sbjct: 286  CKCNGHASECMKNEFDKLVCNC---KHNTYGVDCEKCLP-FFNDRPWRRATAESASECLP 341

Query: 918  CRCNAGGS---FSEVCHSQTGQ----CECRANVQGQRCDKCKAGTFGLQSARGCVPCNCN 970
            C CN       F    +  TG       C+ N  G  C++C+   F L +   C  C+C+
Sbjct: 342  CDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCS 401

Query: 971  SFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG--NNCDPKTG 1028
              GS S  C+  G+C C+PGV G KCDRC  G+ +  E GC  C C   G  + C+ +TG
Sbjct: 402  PVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETG 461

Query: 1029 RCICPPNTIGEKCSKCAPNTWG--HSITTGCKACNC 1062
            RC+C  N  G  C +C P  +    S   GC  C C
Sbjct: 462  RCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC 497



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 30/99 (30%), Positives = 41/99 (41%), Gaps = 11/99 (11%)

Query: 713  TDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI-CEPCQCFGHAE---SCDD 768
            T+G        C+C PG TG  CE C      VN   FG   C+PC C         C D
Sbjct: 943  TNGQCDIRTGQCECQPGITGQHCERC-----EVNHFGFGPEGCKPCDCHPEGSLSLQCKD 997

Query: 769  VTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPC 807
              G C  C++   G  CD+C   ++   +    ++C  C
Sbjct: 998  -DGRC-ECREGFVGNRCDQCEENYFYNRSWPGCQECPAC 1034



 Score = 41.2 bits (95), Expect = 0.016
 Identities = 51/229 (22%), Positives = 97/229 (42%), Gaps = 30/229 (13%)

Query: 1644 VTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETL 1703
            +  +N+ +T A + T + +Q    A    T AK+      E  R A AV + A     T 
Sbjct: 1391 IPAINQTITEANEKTREAQQALGSAAADATEAKNKAH---EAERIASAVQKNA---TSTK 1444

Query: 1704 GTRDEAFERNLEGLQKEIDQMIKELRR--KNLETQKEIAEDELVAAEALLKKVKKLFGES 1761
               +  F   +  L  E++ M+K+L+   K L+ +++ A+ +++ A           G +
Sbjct: 1445 AEAERTFAE-VTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMA-----------GMA 1492

Query: 1762 RGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA-----NRLFAVNQK-NMTALE 1815
                +E E + R+     KN V     ++ +  +++ +      N+L  +    N    E
Sbjct: 1493 SQAAQEAEINARKA----KNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDE 1548

Query: 1816 KKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLP 1864
             K   ++     +EN  K+    + + NR  +EI   I  +EDI+  LP
Sbjct: 1549 MKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLP 1597


>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
          Length = 1575

 Score =  590 bits (1520), Expect = e-168
 Identities = 391/1104 (35%), Positives = 531/1104 (48%), Gaps = 135/1104 (12%)

Query: 1    MPGAAGVLLLLLLS-----GGLGGVQ--AQRPQQQRQSQAHQQRGLFPAVLNLASNALIT 53
            M  AA +L L LL+      G+G     A RPQ+             P   N A   L  
Sbjct: 1    MAAAALLLGLALLAPRAAGAGMGACYDGAGRPQR-----------CLPVFENAAFGRLAQ 49

Query: 54   TNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAID----GKNTW 109
             + TCG   PE +C  V    G       C+ C+  +++P + H  +   D     ++TW
Sbjct: 50   ASHTCGSP-PEDFCPHV----GAAGAGAHCQRCD--AADPQRHHNASYLTDFHSQDESTW 102

Query: 110  WQSPSIKNGIEYHY-VTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQY 168
            WQSPS+  G++Y   V ITL L + ++I YV +K   S      I +RS  D  ++P+Q+
Sbjct: 103  WQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQF 162

Query: 169  HAVTDTECLTLYNI----YPRTGPPSYAKDDEV-ICTSFYSKIHPLENGEIHISLINGRP 223
            ++ +   C   Y      Y R G     +D+ V  CTS +S I PL  G +  S + GRP
Sbjct: 163  YSAS---CQKTYGRPEGQYLRPG-----EDERVAFCTSEFSDISPLSGGNVAFSTLEGRP 214

Query: 224  SAD--DPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDI 281
            SA   + SP L E+ ++  + +   R+ T   D+           DP V + YYY+V D 
Sbjct: 215  SAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFK---------DPKVLQSYYYAVSDF 265

Query: 282  SVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC 341
            SVGG C C GHA  C  D A  +  C C+HNT G  C++C P F  +PW  GT     EC
Sbjct: 266  SVGGRCKCNGHASECGPDVA-GQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHEC 324

Query: 342  EACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPK 401
              CNC G++EEC +D  + R             GG C +C  +TAG +CE C + F+   
Sbjct: 325  LPCNCSGRSEECTFDRELFRSTGH---------GGRCHHCRDHTAGPHCERCQENFYHWD 375

Query: 402  GVSPNYPR-PCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGY 460
                  PR PCQPC C   GSL+  C  D+         G+C CK    G  CDRC  G+
Sbjct: 376  ------PRMPCQPCDCQSAGSLHLQC--DD--------TGTCACKPTVTGWKCDRCLPGF 419

Query: 461  TGYPD--CKACNCSGLGSKNE-DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDE 517
                +  C+ C C+  GS +  DP  G C CKENVEG  C RC+ G FNLQ  N  GC  
Sbjct: 420  HSLSEGGCRPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSS 479

Query: 518  CFCSGVSNRCQSS--YWTYGKIQDM----SGWYLTDLPGRIRVAPQQDDLDSPQQISISN 571
            CFC G S  C S+  +  +  + D      GW+   + G     PQ     SP  + +S 
Sbjct: 480  CFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGS-EHPPQW----SPNGVLLSP 534

Query: 572  AEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGND 631
             +  +        +AP  +LG++  + G  L  T            +  L + + LEG  
Sbjct: 535  EDEEEL-------TAPEKFLGDQRFSYGQPLILTF------RVPPGDSPLPVQLRLEGTG 581

Query: 632  LSISTAQDEVYLHPSEEHTNVLLLK-EESFTIHGTHFPVRRKEFMTVLANLKRVLLQITY 690
            L++S     +       H   + L+     T      P+    F  +LANL  + L+++ 
Sbjct: 582  LALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANLTSLRLRVSP 641

Query: 691  SFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRR--VNGT 748
                     L+ V L SA   P     A+ VE+C CP GYTG  CESC P ++R    G 
Sbjct: 642  GPSPAGPVFLTEVRLTSA--RPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGG 699

Query: 749  IFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCA 808
             +   C PC C  H  +CD  TG C+ C  HT GP C++CLPGFYG P  G ++DCQPC 
Sbjct: 700  PYAS-CVPCTCNQHG-TCDPNTGICV-CSHHTEGPSCERCLPGFYGNPFAGQADDCQPCP 756

Query: 809  CPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQP---C 865
            CP        S    +  S  ++C  CP G  G RCE C +G+FG P    G  QP   C
Sbjct: 757  CP------GQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQC 810

Query: 866  QCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAV---DAKNCQPCRCNA 922
            QC+ N+D +  G+CD LSG CL C   TTG +CE C +G++G A+    A  C PC C+ 
Sbjct: 811  QCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHP 870

Query: 923  GGSFSE--VCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCE 980
             GS SE   C   TGQC C  +V  + C +C  G F LQ  RGC  C C+  GS+   C 
Sbjct: 871  QGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCH 930

Query: 981  -ESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG---NNCDPKTGRCICPPNT 1036
             ++GQC C+PGVTG+ CDRC  G+F F   GC AC CS LG     C  + G C+C P  
Sbjct: 931  PKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCH-ENGTCVCRPGF 989

Query: 1037 IGEKCSKCAPNTWGHSITTGCKAC 1060
             G KC +C  N +  +  T C+ C
Sbjct: 990  EGYKCDRCHDNFFLTADGTHCQQC 1013



 Score =  256 bits (653), Expect = 3e-67
 Identities = 196/638 (30%), Positives = 271/638 (42%), Gaps = 104/638 (16%)

Query: 967  CNCNSFGSKSFDCEESGQ--CWCQPGVTGKKCDRCAHGYFN--FQEGG------CTACEC 1016
            C CN   S+    + +GQ  C CQ   TG  C+RC   + +  +  G       C  C C
Sbjct: 271  CKCNGHASECGP-DVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNC 329

Query: 1017 SHLGNNCD---------PKTGRCI-CPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVG 1066
            S     C             GRC  C  +T G  C +C  N +       C+ C+C + G
Sbjct: 330  SGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAG 389

Query: 1067 SLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCS 1126
            SL  QC+ +TG C C P  +G KC  C  G  +        C        TC+      +
Sbjct: 390  SLHLQCD-DTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPC--------TCNPAGSLDT 440

Query: 1127 CSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWV 1186
            C  ++G+C CK NVEG  CDRCRPG F L   NP GCSSC+C+G +  C+          
Sbjct: 441  CDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQF----- 495

Query: 1187 TLKAEQTILPLVDEALQHTTTKGIV-FQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKK 1245
                   IL    +  +    + +   +HP   +   ++      E      PE+F G +
Sbjct: 496  ---QVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGVLLSPEDEEEL--TAPEKFLGDQ 550

Query: 1246 LMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRH--MAAPLIGQLTRHE 1303
              +YG  L        R   G S    Q+ + G   T   + +RH  ++ P      R E
Sbjct: 551  RFSYGQPLILTF----RVPPGDSPLPVQLRLEG---TGLALSLRHSSLSGPQDAGHPR-E 602

Query: 1304 IEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNF-MRQSR--------- 1353
            +E+            R H   T ED    L   H+  + A   +  +R S          
Sbjct: 603  VEL------------RFHLQETSEDVAPPLPPFHFQRLLANLTSLRLRVSPGPSPAGPVF 650

Query: 1354 ISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPT 1413
            ++E+ +  A  G    ++PPA  +E C CP GY+G  CE+C PG+ R   Q      G  
Sbjct: 651  LTEVRLTSARPG----LSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQ------GGP 700

Query: 1414 LGTCVPCQCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYG-IVKGLPNDCQQCACP 1472
              +CVPC CN H + CDP T IC  C HHT G  CERC  G+YG    G  +DCQ C CP
Sbjct: 701  YASCVPCTCNQHGT-CDPNTGICV-CSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCP 758

Query: 1473 LISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSP----GNPGGSCQECE 1528
              S+      S       +  CT CP G  G+ CE C  G+ G P    G+P   C +C+
Sbjct: 759  GQSACTTIPES------REVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHP-QPCHQCQ 811

Query: 1529 C----DPYGSLPVPCDPVTGFC-TCRPGATGRKCDGCK 1561
            C    DP  +    CDP++G C  C    TG  C+ C+
Sbjct: 812  CSGNVDP--NAVGNCDPLSGHCLRCLHNTTGDHCEHCQ 847



 Score =  197 bits (500), Expect = 2e-49
 Identities = 119/364 (32%), Positives = 159/364 (43%), Gaps = 45/364 (12%)

Query: 831  ICDGCPVGYTGPRCERCAEGYFGQ--PSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLI 888
            IC  CP GYTG  CE CA GY  +     P  SC PC CN +      G+CD  +G C +
Sbjct: 672  ICS-CPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQH------GTCDPNTGIC-V 723

Query: 889  CKPGTTGRYCELCADGYFGD--AVDAKNCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQG 945
            C   T G  CE C  G++G+  A  A +CQPC C    + + +  S+   C  C    +G
Sbjct: 724  CSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRG 783

Query: 946  QRCDKCKAGTFG-----LQSARGCVPCNC--NSFGSKSFDCEE-SGQCW-CQPGVTGKKC 996
            +RC+ C  G FG         + C  C C  N   +   +C+  SG C  C    TG  C
Sbjct: 784  RRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHC 843

Query: 997  DRCAHGYFNFQ-----EGGCTACECSHLGN-----NCDPKTGRCICPPNTIGEKCSKCAP 1046
            + C  G++           C  C C   G+      CDP TG+C C P+     CS+C P
Sbjct: 844  EHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYP 903

Query: 1047 NTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNY--PRCN 1104
              +      GC++C C  +GS + QC+  TGQC C P  +G  C  C  G + +    C 
Sbjct: 904  GFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCR 963

Query: 1105 LCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKF-GLDAKNPLGC 1163
             C C   G  +  C           + G C C+   EG  CDRC    F   D  +   C
Sbjct: 964  ACRCSPLGAASAQC----------HENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQC 1013

Query: 1164 SSCY 1167
             SCY
Sbjct: 1014 PSCY 1017



 Score =  165 bits (418), Expect = 6e-40
 Identities = 105/323 (32%), Positives = 144/323 (44%), Gaps = 52/323 (16%)

Query: 889  CKPGTTGRYCELCADGYFGDAVDA---KNCQPCRCNAGGSFSEVCHSQTGQCECRANVQG 945
            C  G TG++CE CA GY  +        +C PC CN  G+    C   TG C C  + +G
Sbjct: 675  CPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHGT----CDPNTGICVCSHHTEG 730

Query: 946  QRCDKCKAGTFG---LQSARGCVPCNC--NSFGSKSFDCEESGQCWCQPGVTGKKCDRCA 1000
              C++C  G +G      A  C PC C   S  +   +  E     C PG  G++C+ C 
Sbjct: 731  PSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCD 790

Query: 1001 HGYFNFQEG------GCTACECSHLGN-------NCDPKTGRCI-CPPNTIGEKCSKCAP 1046
             G+F    G       C  C+CS  GN       NCDP +G C+ C  NT G+ C  C  
Sbjct: 791  DGFFGDPLGLFGHPQPCHQCQCS--GNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQE 848

Query: 1047 NTWGHSITTG----CKACNCSTVGSLDFQ--CNVNTGQCNCHPKFSGAKCTECSRGHWNY 1100
              +G ++       C  C+C   GS+  Q  C+  TGQC+C P  +   C+ C  G ++ 
Sbjct: 849  GFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDL 908

Query: 1101 PR---CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDA 1157
                 C  C C   G+         ++  C  +TGQCTC+  V G  CDRC+ G FG   
Sbjct: 909  QPGRGCRSCKCHPLGS---------QEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSI 959

Query: 1158 KNPLGCSSCYCF---GTTTQCSE 1177
            K   GC +C C      + QC E
Sbjct: 960  K---GCRACRCSPLGAASAQCHE 979



 Score =  137 bits (346), Expect = 1e-31
 Identities = 74/216 (34%), Positives = 102/216 (47%), Gaps = 22/216 (10%)

Query: 865  CQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYF------GDAVDAKNCQPC 918
            C+CN +     P     L+  C   +  TTG  CE C   +       G A  A  C PC
Sbjct: 271  CKCNGHASECGPDVAGQLACRC---QHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPC 327

Query: 919  RCNAGG---SFSEVCHSQTG---QCE-CRANVQGQRCDKCKAGTFGLQSARGCVPCNCNS 971
             C+      +F       TG   +C  CR +  G  C++C+   +       C PC+C S
Sbjct: 328  NCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQS 387

Query: 972  FGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG--NNCDPKTGR 1029
             GS    C+++G C C+P VTG KCDRC  G+ +  EGGC  C C+  G  + CDP++GR
Sbjct: 388  AGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDTCDPRSGR 447

Query: 1030 CICPPNTIGEKCSKCAPNTWG---HSITTGCKACNC 1062
            C C  N  G  C +C P T+    H+   GC +C C
Sbjct: 448  CPCKENVEGNLCDRCRPGTFNLQPHN-PAGCSSCFC 482



 Score =  120 bits (300), Expect = 3e-26
 Identities = 70/200 (35%), Positives = 90/200 (45%), Gaps = 19/200 (9%)

Query: 1369 TMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL 1428
            T  P +  +    CP G  G  CE C  GF+     P G    P    C  CQC+G+   
Sbjct: 764  TTIPESREVVCTHCPPGQRGRRCEVCDDGFF---GDPLGLFGHPQ--PCHQCQCSGNVDP 818

Query: 1429 -----CDPETSICQNCQHHTAGDFCERCALGYYG--IVKGLPNDCQQCACPLISSSNNFS 1481
                 CDP +  C  C H+T GD CE C  G+YG  +     + C  C+C    S +   
Sbjct: 819  NAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQM 878

Query: 1482 PSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDP 1541
            P     G    +C+  P     + C RC PG+      PG  C+ C+C P GS    C P
Sbjct: 879  PCDPVTG----QCSCLPH-VTARDCSRCYPGFFDL--QPGRGCRSCKCHPLGSQEDQCHP 931

Query: 1542 VTGFCTCRPGATGRKCDGCK 1561
             TG CTCRPG TG+ CD C+
Sbjct: 932  KTGQCTCRPGVTGQACDRCQ 951



 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 156/721 (21%), Positives = 270/721 (37%), Gaps = 144/721 (19%)

Query: 1364 QGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN 1423
            QG  +   P   +  +C C    +   C  C PGF+ L  QPG          C  C+C+
Sbjct: 871  QGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDL--QPG--------RGCRSCKCH 920

Query: 1424 ---GHSSLCDPETSICQNCQHHTAGDFCERCALGYYGI-VKGLPNDCQQCACPLISSSNN 1479
                    C P+T  C  C+    G  C+RC LG++G  +KG    C+ C C  + ++  
Sbjct: 921  PLGSQEDQCHPKTGQC-TCRPGVTGQACDRCQLGFFGFSIKG----CRACRCSPLGAA-- 973

Query: 1480 FSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPC 1539
             S  C   G        C  G+EG  C+RC   +  +    G  CQ+C            
Sbjct: 974  -SAQCHENG-----TCVCRPGFEGYKCDRCHDNFFLTA--DGTHCQQCP----------- 1014

Query: 1540 DPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDEC------TGLLLGDLARLEQMV 1593
               + +   +  A   K          EGW     G +C        +LLG+  R +   
Sbjct: 1015 ---SCYALVKEEAAKLKA----RLTLTEGW---LQGSDCGSPWGPLDILLGEAPRGDVYQ 1064

Query: 1594 MSINLTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELL-- 1651
                L G   A  + +  LE   +  +  L       R  Q       T + ++  +L  
Sbjct: 1065 GHHLLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLES 1124

Query: 1652 -----------TRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLN 1700
                         + ++  +G           T A++L    ++ A    A   +A+  +
Sbjct: 1125 SEEEILHAAAILASLEIPQEGPSQPTKWSHLATEARALARSHRDTATKIAATAWRALLAS 1184

Query: 1701 ETL---------GTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKE----IAEDELVAA 1747
             T          G      +R+LE   +E+    K LR    E   E    +A  + V A
Sbjct: 1185 NTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGA 1244

Query: 1748 E-----ALLKKVKKLFGESRGENEEME-KDLREKLADYKNKVDDAWDLLREATD-KIREA 1800
            +     ALL     L  +SR E+  ++ K L + +A +++   +A   L+ A    +R+ 
Sbjct: 1245 DTAPYLALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQT 1304

Query: 1801 NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ 1860
              L  ++Q+   AL +   +V++              ++     LAD        +E ++
Sbjct: 1305 EPLTKLHQEARAALTQASSSVQAAT----------VTVMGARTLLAD--------LEGMK 1346

Query: 1861 TKLPPMSEE--LNDKIDDLSQEIKDRKLAE---KVSQAE---SHAAQLNDSSAVLDGILD 1912
             + P   ++  L  K D +S    DR LA+   K  QAE    +AA L+ SSA   G   
Sbjct: 1347 LQFPRPKDQAALQRKADSVS----DRLLADTRKKTKQAERMLGNAAPLS-SSAKKKG--R 1399

Query: 1913 EAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQ 1972
            EA+ ++             KD    A+ + +E K     A++L +  +  L++ ++  L 
Sbjct: 1400 EAEVLA-------------KDSAKLAKALLRERKQAHRRASRLTSQTQATLQQASQQVLA 1446

Query: 1973 KSFR--ILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDT 2030
               R   L EA+++   + E E  +   +  +E         + TL++ L +L ++    
Sbjct: 1447 SEARRQELEEAERVGAGLSEMEQQIRESRISLEKD-------IETLSELLARLGSLDTHQ 1499

Query: 2031 A 2031
            A
Sbjct: 1500 A 1500



 Score = 32.7 bits (73), Expect = 5.8
 Identities = 42/187 (22%), Positives = 82/187 (43%), Gaps = 10/187 (5%)

Query: 1656 KVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLE 1715
            ++ AD  +  + AER    A  L    K+  R+AE + + + KL + L    +   R   
Sbjct: 1368 RLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRAS 1427

Query: 1716 GLQKEIDQMIKELRRKNLETQ---KEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDL 1772
             L  +    +++  ++ L ++   +E+ E E V A   L ++++   ESR   E+  + L
Sbjct: 1428 RLTSQTQATLQQASQQVLASEARRQELEEAERVGAG--LSEMEQQIRESRISLEKDIETL 1485

Query: 1773 REKLA-----DYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQ 1827
             E LA     D       A +  + A +++R         Q+ ++ LE++ +  E   + 
Sbjct: 1486 SELLARLGSLDTHQAPAQALNETQWALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQG 1545

Query: 1828 IENTLKE 1834
             E+ L E
Sbjct: 1546 FESDLAE 1552


>gi|21264602 laminin alpha 5 [Homo sapiens]
          Length = 3695

 Score =  469 bits (1207), Expect = e-131
 Identities = 275/781 (35%), Positives = 377/781 (48%), Gaps = 77/781 (9%)

Query: 306  RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
            +C C  +  G  C +C  G+   P           C  C+C  +      DE        
Sbjct: 1456 QCPCHAHVIGRDCSRCATGYWGFP----------NCRPCDCGARL----CDELT------ 1495

Query: 366  LNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGS---L 422
                      G CI C   T   +C  C    F   G  P     C+ C+C   G     
Sbjct: 1496 ----------GQCI-CPPRTIPPDCLLCQPQTF---GCHPLVG--CEECNCSGPGIQELT 1539

Query: 423  NEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNE--D 480
            +  C  D          G C C+    G  CD C+ G+ GYP C+ C+C   G+     D
Sbjct: 1540 DPTCDTDS---------GQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCD 1590

Query: 481  PCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDM 540
            P  G C CKENV+G  C +C  G F+L   N KGC  CFC G + RC+SS +T  +  DM
Sbjct: 1591 PLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFCFGATERCRSSSYTRQEFVDM 1650

Query: 541  SGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSY---YWSAPAPYLGNKLPA 597
             GW L     ++    +Q      + +        +A+P ++   YW AP  YLG+++ +
Sbjct: 1651 EGWVLLSTDRQVVPHERQP---GTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSS 1707

Query: 598  VGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKE 657
             GG L + +  + +  +       +  ++L+GN +SI T  +  Y  P   H   L L E
Sbjct: 1708 YGGTLRYELHSETQRGDVFVPMESRPDVVLQGNQMSI-TFLEPAYPTPGHVHRGQLQLVE 1766

Query: 658  ESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSI 717
             +F    T   V R+E M VLA+L+++ ++  +S    A+F L  V LE A S    G++
Sbjct: 1767 GNFRHTETRNTVSREELMMVLASLEQLQIRALFSQISSAVF-LRRVALEVA-SPAGQGAL 1824

Query: 718  AAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCK 777
            A+ VE+C CP  Y G SC+ C P   R    +F G C PCQC GH++ C   +G C++C+
Sbjct: 1825 ASNVELCLCPASYRGDSCQECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQ 1884

Query: 778  DHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPV 837
             +T G +C++C  GF        S  C  C CPL++PSNNF+  C L    G     C  
Sbjct: 1885 HNTEGAHCERCQAGFVSS-RDDPSAPCVSCPCPLSVPSNNFAEGCVLRG--GRTQCLCKP 1941

Query: 838  GYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGS-CDSLSGSCLICKPGTTGR 896
            GY G  CERCA G+FG P V G SCQPC C+ N D ++  S CD L+G+C  C   TTG 
Sbjct: 1942 GYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGP 2001

Query: 897  YCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTF 956
             CE+CA G++G+A+   NC  C C   G+  E C   +G C C+A V G+RCD+C+ G F
Sbjct: 2002 RCEICAPGFYGNALLPGNCTRCDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHF 2059

Query: 957  GLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACEC 1016
            G     GC PC C      S    +SGQC C+PG  G +C  CA GY+   E GC  C+C
Sbjct: 2060 GFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRCQC 2119

Query: 1017 SHLGNNCDPKTGRCICPPNTIGEKCSKCAP--------NTWGHSITTGCKACNCSTVGSL 1068
               G  CDP TGRC CPP   GE+C  C+            GHSI   C+ C+   V  L
Sbjct: 2120 P--GGRCDPHTGRCNCPPGLSGERCDTCSQQHQVPVPGGPVGHSI--HCEVCDHCVVLLL 2175

Query: 1069 D 1069
            D
Sbjct: 2176 D 2176



 Score =  440 bits (1131), Expect = e-122
 Identities = 241/574 (41%), Positives = 314/574 (54%), Gaps = 84/574 (14%)

Query: 3   GAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKG 62
           G  G   LLL+   L G    R       +A     L P   NLA  A I  +ATCGE+ 
Sbjct: 15  GPRGPAPLLLVGLALLGAARAR------EEAGGGFSLHPPYFNLAEGARIAASATCGEEA 68

Query: 63  P---------EMYCKLVEHV-----PGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNT 108
           P         ++YCKLV        P Q +R   C IC   ++N N+ HP +NAIDG   
Sbjct: 69  PARGSPRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICT--AANSNKAHPASNAIDGTER 126

Query: 109 WWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLD-DVEYKPWQ 167
           WWQSP +  G+EY+ V +TLDL QVF +AYV++K ANSPRP  W+LERS+D    Y+PWQ
Sbjct: 127 WWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGRTYQPWQ 186

Query: 168 YHAVTDTECLTLYNIYPRTGPPSY---AKDDEVICTSFYSKIHPLENGEIHISLINGRPS 224
           + A +  +CL       R GP +     +DD  ICT+ YS+I PLENGEI +SL+NGRP 
Sbjct: 187 FFASSKRDCLE------RFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPG 240

Query: 225 ADD--PSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDIS 282
           A +   SP L EFT A  +RLRF R  TL   LM  A +DP      VTRRYYYS+KDIS
Sbjct: 241 AMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALRDPT-----VTRRYYYSIKDIS 295

Query: 283 VGGMCICYGHARACPLDPATNKSR--CECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTE 340
           +GG C+C+GHA AC     T+  R  C C+HNTCG +CD+CCPGF+Q+PW+  T  +  E
Sbjct: 296 IGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANE 355

Query: 341 CEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRP 400
           C++CNC+G A +CYYD  V RR  S ++ G Y GGGVCI+C  +T G+NCE C  GF+R 
Sbjct: 356 CQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRS 415

Query: 401 KGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGY 460
                + P  C+ C+C+      +   +D          G C+C+  F G  CD CA G+
Sbjct: 416 PNHPLDSPHVCRRCNCE--SDFTDGTCED--------LTGRCYCRPNFSGERCDVCAEGF 465

Query: 461 TGYPDCKA--------------------CNCSGLGSK----NEDPCFGPCICKENVEGGD 496
           TG+P C                      C+CS  G++     +DP  G C+CK N +G  
Sbjct: 466 TGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTH 525

Query: 497 CSRCKSGFFNLQEDNWKGCDECFCSG---VSNRC 527
           C  C  GF+        GC  C CS      +RC
Sbjct: 526 CELCAPGFYG------PGCQPCQCSSPGVADDRC 553



 Score =  394 bits (1011), Expect = e-108
 Identities = 225/634 (35%), Positives = 303/634 (47%), Gaps = 77/634 (12%)

Query: 953  AGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGC 1011
            A +  L    G  PC C+  G+    CE   GQC C   V G+ C RCA GY+ F    C
Sbjct: 1424 AASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPN--C 1481

Query: 1012 TACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGS---L 1068
              C+C      CD  TG+CICPP TI   C  C P T+G     GC+ CNCS  G     
Sbjct: 1482 RPCDCG--ARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELT 1539

Query: 1069 DFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCS 1128
            D  C+ ++GQC C P  +G +C  CS G   YPRC  CDC   GT    CD         
Sbjct: 1540 DPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDP-------- 1591

Query: 1129 DQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGL------I 1182
              TGQC CK NV+G  CD+C  G F LDA NP GC+ C+CFG T +C  +         +
Sbjct: 1592 -LTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFCFGATERCRSSSYTRQEFVDM 1650

Query: 1183 RTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEP---------F 1233
              WV L  ++ ++P       H    G            +++R DL   P          
Sbjct: 1651 EGWVLLSTDRQVVP-------HERQPGT-----------EMLRADLRHVPEAVPEAFPEL 1692

Query: 1234 YWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYN--PQVIIRGGTPTHARIIVRHM 1291
            YW+ P  + G ++ +YGG L+Y ++ E +    F      P V+++G   +   I     
Sbjct: 1693 YWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVFVPMESRPDVVLQGNQMS---ITFLEP 1749

Query: 1292 AAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQ 1351
            A P  G + R ++++ E  +++         TV+RE+ + +L  +  + I+A +      
Sbjct: 1750 AYPTPGHVHRGQLQLVEGNFRH----TETRNTVSREELMMVLASLEQLQIRALFSQISSA 1805

Query: 1352 SRISEISMEVAEQ-GRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTP 1410
              +  +++EVA   G+G      A  +E C CP  Y G SC+ C PGFYR          
Sbjct: 1806 VFLRRVALEVASPAGQGAL----ASNVELCLCPASYRGDSCQECAPGFYR-------DVK 1854

Query: 1411 GPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCA 1470
            G  LG CVPCQC+GHS  C P + +C +CQH+T G  CERC  G+          C  C 
Sbjct: 1855 GLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEGAHCERCQAGFVSSRDDPSAPCVSCP 1914

Query: 1471 CPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECD 1530
            CPL   SNNF+  CV  G    +C  C  GY G  CERCAPG+ G+P   G SCQ C+C 
Sbjct: 1915 CPLSVPSNNFAEGCVLRG-GRTQC-LCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCS 1972

Query: 1531 PYGS---LPVPCDPVTGFCT-CRPGATGRKCDGC 1560
              G    L   CDP+TG C  C    TG +C+ C
Sbjct: 1973 GNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEIC 2006



 Score =  358 bits (919), Expect = 5e-98
 Identities = 444/1895 (23%), Positives = 744/1895 (39%), Gaps = 288/1895 (15%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHS------SLCDPE 1432
            +C C  GY+G SCE C PGF+          P     +C PC C+G+       S CDP 
Sbjct: 1936 QCLCKPGYAGASCERCAPGFFG--------NPLVLGSSCQPCDCSGNGDPNLLFSDCDPL 1987

Query: 1433 TSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSS--NNFSPSCVAE-GL 1489
            T  C+ C  HT G  CE CA G+YG    LP +C +C C    +   +  S  C+ + G+
Sbjct: 1988 TGACRGCLRHTTGPRCEICAPGFYGNAL-LPGNCTRCDCTPCGTEACDPHSGHCLCKAGV 2046

Query: 1490 DDYRCTACPRGY------------------------------------EGQYCERCAPGY 1513
               RC  C  G+                                     G  C  CAPGY
Sbjct: 2047 TGRRCDRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGY 2106

Query: 1514 TGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWH--------A 1565
             G P      C+ C+C P G     CDP TG C C PG +G +CD C   H         
Sbjct: 2107 WGLPEQ---GCRRCQC-PGGR----CDPHTGRCNCPPGLSGERCDTCSQQHQVPVPGGPV 2158

Query: 1566 REGWECVFCGDECTGLLLGDLAR-------LEQMVMSINLTGPLPAP-YKMLYGLENMTQ 1617
                 C  C D C  LLL DL R       + + +  IN +    A  +++   + ++  
Sbjct: 2159 GHSIHCEVC-DHCVVLLLDDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQS 2217

Query: 1618 ELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKS 1677
            +L+  L P+    + +++ E    +L  +   L  +A        Q     E T   AK+
Sbjct: 2218 QLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKT 2277

Query: 1678 LGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQK 1737
            L   I+ + R    +  +   L   L          L     E+++++ E+R ++L   +
Sbjct: 2278 LLAAIRAVDRTLSELMSQTGHLG--LANASAPSGEQLLRTLAEVERLLWEMRARDLGAPQ 2335

Query: 1738 EIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKI 1797
              AE EL AA+ LL +V++       EN+ +    R++LA ++  + D  + L  A D  
Sbjct: 2336 AAAEAELAAAQRLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDAT 2395

Query: 1798 REANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVE 1857
            REA  L + NQ+ +    ++K+ +      ++ TL    D L    RL   ++   + +E
Sbjct: 2396 REAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELE 2455

Query: 1858 DIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQ-----LNDSSAVLDGILD 1912
             +   L      L  ++   S      +L E    AE+HA Q     LN SS +LD   D
Sbjct: 2456 RLAASLDGARTPLLQRMQTFSPAGSKLRLVE---AAEAHAQQLGQLALNLSSIILDVNQD 2512

Query: 1913 EAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQ 1972
                ++  A  A  AYS I   +  AE  A +A   A      AT  R       +G + 
Sbjct: 2513 ---RLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHT--WATVVR-------QGLVD 2560

Query: 1973 KSFRILNEAKKLANDVKENEDH-------LNGLKTRIENADARNGDLLRTLNDTLGKLSA 2025
            ++ ++L  +  L   + + +         L G +T++ +  A+   L   +      L+ 
Sbjct: 2561 RAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAM 2620

Query: 2026 IPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKD 2085
              ++T+ K+   K  A +A DTA  V +Q+  + +N++  +  Y  L           + 
Sbjct: 2621 DTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGL-----------RG 2669

Query: 2086 PSKNKIIADADATVKNLEQEADRLIDKL-----KPIKELEDNLKKNISEIKELINQARKQ 2140
                + + DA  +V  LE+   +L+ KL     + +      L  +I  ++ELI QAR  
Sbjct: 2670 QDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGRVRELIAQARGA 2729

Query: 2141 ANSIKVSVSSGGDC---IRTYKPEIKKGSYNNIVVNVK-------TAVADNLLFYLGSAK 2190
            A+ +KV +   G     +RT +      +Y  +   ++           D  + Y+GS +
Sbjct: 2730 ASKVKVPMKFNGRSGVQLRTPRDLADLAAYTALKFYLQGPEPEPGQGTEDRFVMYMGSRQ 2789

Query: 2191 FI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVA---SRTGRNGTISVR 2246
               D++ + +R  KV +++ +G     V    L+ID+    +  A    RT + G +SV 
Sbjct: 2790 ATGDYMGVSLRDKKVHWVYQLGEAGPAV----LSIDEDIGEQFAAVSLDRTLQFGHMSVT 2845

Query: 2247 ALDGPKASIVPSTHHSTSPPGYT-ILDVDANAMLF-VGGLTGKLKKADAVRVITFTGCMG 2304
                 +  ++  T   T  PG   +L++  +  +F VGG          +R   + GC+ 
Sbjct: 2846 V----ERQMIQETKGDTVAPGAEGLLNLRPDDFVFYVGGYPSTFTPPPLLRFPGYRGCIE 2901

Query: 2305 ETYFDNKPIGLWNF-REKEGDC---KGCTVSPQVED---SEGTIQFDGEGYALVSRPIRW 2357
                + + + L+NF R  + D    + C  S    D   ++G+   DG G+A +S    +
Sbjct: 2902 MDTLNEEVVSLYNFERTFQLDTAVDRPCARSKSTGDPWLTDGS-YLDGTGFARIS----F 2956

Query: 2358 YPNISTVM---FKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSN 2414
               IST      + R  S S +L +L  +    F+ + + +G + + YD G+G+   V  
Sbjct: 2957 DSQISTTKRFEQELRLVSYSGVLFFL--KQQSQFLCLAVQEGSLVLLYDFGAGLKKAVPL 3014

Query: 2415 Q-----NHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIY 2469
            Q            + F L   +K+  + +       E     S   +N   DL+  D  Y
Sbjct: 3015 QPPPPLTSASKAIQVFLLGGSRKRVLVRV-------ERATVYSVEQDN---DLELADAYY 3064

Query: 2470 FGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVY-- 2527
             GG+P  +      R         GC+K I+ +   Y  L   +  GV+ GC+ + +   
Sbjct: 3065 LGGVPPDQLPPSLRRLFPTGGSVRGCVKGIK-ALGKYVDLKRLNTTGVSAGCTADLLVGR 3123

Query: 2528 TVSFPKPGFVEL---SPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQA 2584
             ++F   GF+ L   +  P+         F +  +S ++               R +   
Sbjct: 3124 AMTFHGHGFLRLALSNVAPLTGNVYSGFGFHSAQDSALLYY-------------RASPDG 3170

Query: 2585 YYVILLNRGRLEVH-LSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENR 2643
               + L +GR+ +  L T  +T            F DG  H V          + VD+  
Sbjct: 3171 LCQVSLQQGRVSLQLLRTEVKTQAG---------FADGAPHYVAFYSNATGVWLYVDDQL 3221

Query: 2644 RYMQNLTVEQPIEVKKLFVGGAPPEFQPSP-------LRNIPP------FEGCIWNLVIN 2690
            + M+                G PPE QP P       L  +P       F GCI N+ + 
Sbjct: 3222 QQMKPHR-------------GPPPELQPQPEGPPRLLLGGLPESGTIYNFSGCISNVFVQ 3268

Query: 2691 SV-----PMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPV 2745
             +       D  + +   N   G CA   L+    G  P  +    +     A       
Sbjct: 3269 RLLGPQRVFDLQQNLGSVNVSTG-CA-PALQAQTPGLGPRGL----QATARKASRRSRQP 3322

Query: 2746 LTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYM 2805
              H  C           S QFG S +SH+       + +N  ++ + V   +  GLL + 
Sbjct: 3323 ARHPACMLPPHLRTTRDSYQFGGSLSSHLEFVGILARHRNWPSLSMHVLPRSSRGLLLFT 3382

Query: 2806 ARINHADFATVQLRNGLPYFSYDLGSGD-----------THTMIPTKINDGQWHKIKIMR 2854
            AR          LR G P  +  L +G                   +   G+WHK+ +  
Sbjct: 3383 AR----------LRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQRSRPGRWHKVSVRW 3432

Query: 2855 SKQEGILYVDGA----SNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCV 2910
             K   +L  DGA            +         L+VGGLP +  + ++ PVT    GCV
Sbjct: 3433 EKNRILLVTDGARAWSQEGPHRQHQGAEHPQPHTLFVGGLPASSHSSKL-PVTVGFSGCV 3491

Query: 2911 RNLHMAEAPADLEQPTSSFHVGTCFAN-AQRGTYFDGTGFAKAVGGFKVGL-DLLVEFEF 2968
            + L +   P  L  PT    V  C     + G +F G+G    +      L D+ +E E 
Sbjct: 3492 KRLRLHGRP--LGAPTRMAGVTPCILGPLEAGLFFPGSGGVITLDLPGATLPDVGLELEV 3549

Query: 2969 RTTTTTGVLLGISSQKMDG-MGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHK 3027
            R    TG++  +   +    + +++ +++++   D+GAG F+       P  LCDGQWH+
Sbjct: 3550 RPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGEFST--SVTRPSVLCDGQWHR 3607

Query: 3028 VTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGC 3087
            +   K  + + L VD        P  A+ +A    P+++GG P+ +       +  + GC
Sbjct: 3608 LAVMKSGNVLRLEVDAQSNHTVGPLLAA-AAGAPAPLYLGGLPEPMAVQPWPPA--YCGC 3664

Query: 3088 IRSLKLTKGTGKPLEVNFAKALELRGVQPVS-CPA 3121
            +R L + +       V   +++E+ G    S CPA
Sbjct: 3665 MRRLAVNRS-----PVAMTRSVEVHGAVGASGCPA 3694



 Score =  276 bits (707), Expect = 2e-73
 Identities = 163/506 (32%), Positives = 216/506 (42%), Gaps = 81/506 (16%)

Query: 724  CQCPPGYTGSSCESCWPRHR----RVNGTIFGGICEPCQCFGHAESCD------------ 767
            C C     G +C+ C P       +         C+ C C+GHA  C             
Sbjct: 322  CTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRASQ 381

Query: 768  --DVT----GECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED--CQPCACPLNIPSNNFS 819
              D T    G C++C+ HT G  C++CLPGFY  P         C+ C C  +       
Sbjct: 382  SLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDG--- 438

Query: 820  PTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPS---------------VPGGSCQP 864
             TC     L   C  C   ++G RC+ CAEG+ G PS               +P G    
Sbjct: 439  -TCE---DLTGRCY-CRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVN 493

Query: 865  CQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGG 924
            C C+           D   G CL CKP   G +CELCA G++G       CQPC+C++ G
Sbjct: 494  CDCSAAGTQGNACRKDPRVGRCL-CKPNFQGTHCELCAPGFYGPG-----CQPCQCSSPG 547

Query: 925  SFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQ 984
               + C   TGQC CR   +G  CD+C  G F       C  C C+  G+    C+E+G+
Sbjct: 548  VADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPL---CQLCGCSPAGTLPEGCDEAGR 604

Query: 985  CWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG--NNCDPKTGRCICPPNTIGEKCS 1042
            C CQP   G  CDRC  GY  F    C AC C   G  +      G C C P   G  C 
Sbjct: 605  CLCQPEFAGPHCDRCRPGYHGFPN--CQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQ 662

Query: 1043 KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPR 1102
            +C+P   G      C  C+CS  GSL   C+  +GQC+C P+ +G +C  C  G +N+P 
Sbjct: 663  ECSPGFHGFP---SCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPY 719

Query: 1103 CNLCDCFLPG---TDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKN 1159
            C    C   G    D    +++            C C+ +VEG  CDRC+PG +GL   N
Sbjct: 720  CEAGSCHPAGLAPVDPALPEAQV----------PCMCRAHVEGPSCDRCKPGFWGLSPSN 769

Query: 1160 PLGCSSCYC-----FGTTTQCSEAKG 1180
            P GC+ C C      G   +C    G
Sbjct: 770  PEGCTRCSCDLRGTLGGVAECQPGTG 795



 Score =  234 bits (598), Expect = 8e-61
 Identities = 157/464 (33%), Positives = 201/464 (43%), Gaps = 80/464 (17%)

Query: 713  TDGSIAAAVEVCQCPPGYTGSSCE----------SCWPRHRRVNGT----IFGGICEPCQ 758
            TDG+       C C P ++G  C+          SC+P     N T    +  G    C 
Sbjct: 436  TDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCD 495

Query: 759  CF-----GHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNI 813
            C      G+A   D   G CL CK +  G +C+ C PGFYG         CQPC C    
Sbjct: 496  CSAAGTQGNACRKDPRVGRCL-CKPNFQGTHCELCAPGFYGP-------GCQPCQCS--- 544

Query: 814  PSNNFSPTCHLDRSLGLICDG------CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQC 867
                 SP    DR     CD       C VG+ G  C+RCA GYF  P      CQ C C
Sbjct: 545  -----SPGVADDR-----CDPDTGQCRCRVGFEGATCDRCAPGYFHFPL-----CQLCGC 589

Query: 868  NDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFS 927
            +     ++P  CD  +G CL C+P   G +C+ C  GY G      NCQ C C+  G+  
Sbjct: 590  SPA--GTLPEGCDE-AGRCL-CQPEFAGPHCDRCRPGYHG----FPNCQACTCDPRGALD 641

Query: 928  EVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCE-ESGQCW 986
            ++C +  G C CR    G  C +C  G  G  S   CVPC+C++ GS    C+  SGQC 
Sbjct: 642  QLCGAG-GLCRCRPGYTGTACQECSPGFHGFPS---CVPCHCSAEGSLHAACDPRSGQCS 697

Query: 987  CQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLG-NNCDPKTGR----CICPPNTIGEKC 1041
            C+P VTG +CD C  G +NF    C A  C   G    DP        C+C  +  G  C
Sbjct: 698  CRPRVTGLRCDTCVPGAYNFPY--CEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSC 755

Query: 1042 SKCAPNTWGHSITT--GCKACNCSTVGSLD--FQCNVNTGQCNCHPKFSGAKCTECSRGH 1097
             +C P  WG S +   GC  C+C   G+L    +C   TGQC C P   G  C  C  G 
Sbjct: 756  DRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGF 815

Query: 1098 W-----NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTC 1136
            +     +Y  C  C C + G    +C+  T  C C   T   TC
Sbjct: 816  FGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTC 859



 Score =  226 bits (577), Expect = 2e-58
 Identities = 130/394 (32%), Positives = 173/394 (43%), Gaps = 60/394 (15%)

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHA---ESCDDVTGECLNCKDHT 780
            C C P + G+ CE C P         +G  C+PCQC       + CD  TG+C  C+   
Sbjct: 515  CLCKPNFQGTHCELCAPG-------FYGPGCQPCQCSSPGVADDRCDPDTGQC-RCRVGF 566

Query: 781  GGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTC-HLDRSLGLICDGCPVGY 839
             G  CD+C PG++  P       CQ C C    P+      C    R L      C   +
Sbjct: 567  EGATCDRCAPGYFHFPL------CQLCGCS---PAGTLPEGCDEAGRCL------CQPEF 611

Query: 840  TGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSL--SGSCLICKPGTTGRY 897
             GP C+RC  GY G P+     CQ C C+        G+ D L  +G    C+PG TG  
Sbjct: 612  AGPHCDRCRPGYHGFPN-----CQACTCDPR------GALDQLCGAGGLCRCRPGYTGTA 660

Query: 898  CELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFG 957
            C+ C+ G+ G      +C PC C+A GS    C  ++GQC CR  V G RCD C  G + 
Sbjct: 661  CQECSPGFHG----FPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYN 716

Query: 958  LQSARGCVPCNCNSFGSKSFDC---EESGQCWCQPGVTGKKCDRCAHGYFNFQEG---GC 1011
                  C   +C+  G    D    E    C C+  V G  CDRC  G++        GC
Sbjct: 717  FPY---CEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGC 773

Query: 1012 TACECSHLGN-----NCDPKTGRCICPPNTIGEKCSKCAPNTWG--HSITTGCKACNCST 1064
            T C C   G       C P TG+C C P+  G+ C+ C    +G   +   GC++C C  
Sbjct: 774  TRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGCRSCRCDI 833

Query: 1065 VGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHW 1098
             G+L   C   TG C C P   G  C+E +R H+
Sbjct: 834  GGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867



 Score =  198 bits (503), Expect = 8e-50
 Identities = 110/335 (32%), Positives = 153/335 (45%), Gaps = 43/335 (12%)

Query: 835  CPVGYTGPRCERCAEGYFGQPSVPG---GSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP 891
            CP  Y G  C+ CA G++    V G   G C PCQC+ + D  +PGS     G C+ C+ 
Sbjct: 1833 CPASYRGDSCQECAPGFYRD--VKGLFLGRCVPCQCHGHSDRCLPGS-----GVCVDCQH 1885

Query: 892  GTTGRYCELCADGYFGDAVD-AKNCQPCRCNAG---GSFSEVCHSQTG--QCECRANVQG 945
             T G +CE C  G+     D +  C  C C       +F+E C  + G  QC C+    G
Sbjct: 1886 NTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAG 1945

Query: 946  QRCDKCKAGTFG--LQSARGCVPCNCNSFGSKSF---DCEE-SGQC-WCQPGVTGKKCDR 998
              C++C  G FG  L     C PC+C+  G  +    DC+  +G C  C    TG +C+ 
Sbjct: 1946 ASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEI 2005

Query: 999  CAHGYFN--FQEGGCTACECSHLGNN-CDPKTGRCICPPNTIGEKCSKCAPNTWGHSITT 1055
            CA G++      G CT C+C+  G   CDP +G C+C     G +C +C    +G     
Sbjct: 2006 CAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG 2065

Query: 1056 GCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPR--CNLCDCFLPGT 1113
            GC+ C C        +C+  +GQC+C P   G +C EC+ G+W  P   C  C C  PG 
Sbjct: 2066 GCRPCACGPAAE-GSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRCQC--PGG 2122

Query: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRC 1148
                         C   TG+C C   + G  CD C
Sbjct: 2123 ------------RCDPHTGRCNCPPGLSGERCDTC 2145



 Score =  179 bits (455), Expect = 3e-44
 Identities = 110/348 (31%), Positives = 149/348 (42%), Gaps = 73/348 (20%)

Query: 889  CKPGTTGRYCELCADGYF------GDAVDAKNCQPCRC---------------NAGGSFS 927
            C+  T G  C+ C  G+         A  A  CQ C C                      
Sbjct: 324  CQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRASQSL 383

Query: 928  EVCHSQTGQC-ECRANVQGQRCDKCKAGTFG-----LQSARGCVPCNCNSFGSKSFDCEE 981
            +  +   G C +C+ +  G  C++C  G +      L S   C  CNC S  +    CE+
Sbjct: 384  DGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDG-TCED 442

Query: 982  -SGQCWCQPGVTGKKCDRCAHGYFNFQE------------------GGCTACECSHLG-- 1020
             +G+C+C+P  +G++CD CA G+  F                    G    C+CS  G  
Sbjct: 443  LTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQ 502

Query: 1021 -NNC--DPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTG 1077
             N C  DP+ GRC+C PN  G  C  CAP  +G     GC+ C CS+ G  D +C+ +TG
Sbjct: 503  GNACRKDPRVGRCLCKPNFQGTHCELCAPGFYG----PGCQPCQCSSPGVADDRCDPDTG 558

Query: 1078 QCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCK 1137
            QC C   F GA C  C+ G++++P C LC C   GT    C          D+ G+C C+
Sbjct: 559  QCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGC----------DEAGRCLCQ 608

Query: 1138 VNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC--FGTTTQCSEAKGLIR 1183
                G HCDRCRPG  G        C +C C   G   Q   A GL R
Sbjct: 609  PEFAGPHCDRCRPGYHGFP-----NCQACTCDPRGALDQLCGAGGLCR 651



 Score =  165 bits (417), Expect = 7e-40
 Identities = 110/369 (29%), Positives = 167/369 (45%), Gaps = 50/369 (13%)

Query: 888  ICKPGTTGRYCELCADGYFGDA--VDAKNCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQ 944
            +C     G  C+ CA G++ D   +    C PC+C+     S+ C   +G C +C+ N +
Sbjct: 1832 LCPASYRGDSCQECAPGFYRDVKGLFLGRCVPCQCHG---HSDRCLPGSGVCVDCQHNTE 1888

Query: 945  GQRCDKCKAGTFGLQS--ARGCVPCNCN-SFGSKSF--DCEESG---QCWCQPGVTGKKC 996
            G  C++C+AG    +   +  CV C C  S  S +F   C   G   QC C+PG  G  C
Sbjct: 1889 GAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAGASC 1948

Query: 997  DRCAHGYFN---FQEGGCTACECSHLGN------NCDPKTGRCI-CPPNTIGEKCSKCAP 1046
            +RCA G+F         C  C+CS  G+      +CDP TG C  C  +T G +C  CAP
Sbjct: 1949 ERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAP 2008

Query: 1047 NTWGHSITTG-CKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNL 1105
              +G+++  G C  C+C+  G+    C+ ++G C C    +G +C  C  GH+ +  C  
Sbjct: 2009 GFYGNALLPGNCTRCDCTPCGTE--ACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGG 2066

Query: 1106 CDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSS 1165
            C           C    +   C  Q+GQC C+    G  C  C PG +GL  +   GC  
Sbjct: 2067 CR-------PCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQ---GCRR 2116

Query: 1166 CYCFG-----TTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAH 1220
            C C G      T +C+   GL        ++Q  +P+    + H+        H E+  H
Sbjct: 2117 CQCPGGRCDPHTGRCNCPPGLSGERCDTCSQQHQVPVPGGPVGHSI-------HCEVCDH 2169

Query: 1221 -MDLMREDL 1228
             + L+ +DL
Sbjct: 2170 CVVLLLDDL 2178



 Score =  136 bits (343), Expect = 3e-31
 Identities = 80/242 (33%), Positives = 107/242 (44%), Gaps = 31/242 (12%)

Query: 717 IAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI--CEPCQCFGHAE---SCDDVTG 771
           +  A  +C+C PGYTG++C+ C P         F G   C PC C        +CD  +G
Sbjct: 643 LCGAGGLCRCRPGYTGTACQECSPG--------FHGFPSCVPCHCSAEGSLHAACDPRSG 694

Query: 772 ECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCA-CPLNIPSNNFSPTCHLDRSLGL 830
           +C +C+    G  CD C+PG Y  P       C P    P++         C        
Sbjct: 695 QC-SCRPRVTGLRCDTCVPGAYNFPYCEAGS-CHPAGLAPVDPALPEAQVPCM------- 745

Query: 831 ICDGCPVGYTGPRCERCAEGYFG-QPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLIC 889
               C     GP C+RC  G++G  PS P G C  C C+          C   +G C  C
Sbjct: 746 ----CRAHVEGPSCDRCKPGFWGLSPSNPEG-CTRCSCDLRGTLGGVAECQPGTGQCF-C 799

Query: 890 KPGTTGRYCELCADGYFG-DAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRC 948
           KP   G+ C  C DG+FG D  D   C+ CRC+ GG+  + C  +TG C CR N QG  C
Sbjct: 800 KPHVCGQACASCKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTC 859

Query: 949 DK 950
            +
Sbjct: 860 SE 861



 Score =  129 bits (325), Expect = 3e-29
 Identities = 85/267 (31%), Positives = 116/267 (43%), Gaps = 43/267 (16%)

Query: 937  CECRANVQGQRCDKCKAGTF----GLQSARGCVPCNCNSFGSKSFDCEESGQCW-CQPGV 991
            C C A+ +G  C +C  G +    GL   R CVPC C+    +      SG C  CQ   
Sbjct: 1831 CLCPASYRGDSCQECAPGFYRDVKGLFLGR-CVPCQCHGHSDRCLP--GSGVCVDCQHNT 1887

Query: 992  TGKKCDRCAHGYFNFQE---GGCTACEC------SHLGNNCDPKTGR--CICPPNTIGEK 1040
             G  C+RC  G+ + ++     C +C C      ++    C  + GR  C+C P   G  
Sbjct: 1888 EGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAGAS 1947

Query: 1041 CSKCAPNTWGHSITTG--CKACNCSTVGS---LDFQCNVNTGQCN-CHPKFSGAKCTECS 1094
            C +CAP  +G+ +  G  C+ C+CS  G    L   C+  TG C  C    +G +C  C+
Sbjct: 1948 CERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICA 2007

Query: 1095 RGHWNYP----RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRP 1150
             G +        C  CDC   GT+A           C   +G C CK  V G  CDRC+ 
Sbjct: 2008 PGFYGNALLPGNCTRCDCTPCGTEA-----------CDPHSGHCLCKAGVTGRRCDRCQE 2056

Query: 1151 GKFGLDAKNPLGCSSCYCFGTTTQCSE 1177
            G FG D     GC  C C G   + SE
Sbjct: 2057 GHFGFDGCG--GCRPCAC-GPAAEGSE 2080



 Score =  125 bits (315), Expect = 5e-28
 Identities = 92/296 (31%), Positives = 111/296 (37%), Gaps = 67/296 (22%)

Query: 936  QCECRANVQGQRCDKCKAGTFGLQ--------SARGCVPCNCNSF--------------G 973
            QC C+ N  G  CD+C  G F  Q        SA  C  CNC                  
Sbjct: 321  QCTCQHNTCGGTCDRCCPG-FNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRA 379

Query: 974  SKSFD--CEESGQCW-CQPGVTGKKCDRCAHGYFNFQEGG------CTACEC--SHLGNN 1022
            S+S D   +  G C  CQ   TG  C+RC  G++            C  C C        
Sbjct: 380  SQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGT 439

Query: 1023 CDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKA-----------------CNCSTV 1065
            C+  TGRC C PN  GE+C  CA    G        +                 C+CS  
Sbjct: 440  CEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAA 499

Query: 1066 GSLDFQC--NVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETK 1123
            G+    C  +   G+C C P F G  C  C+ G +  P C  C C  PG     CD +  
Sbjct: 500  GTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYG-PGCQPCQCSSPGVADDRCDPD-- 556

Query: 1124 KCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQ-CSEA 1178
                   TGQC C+V  EG  CDRC PG F        GCS     GT  + C EA
Sbjct: 557  -------TGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPA---GTLPEGCDEA 602



 Score =  117 bits (293), Expect = 2e-25
 Identities = 85/269 (31%), Positives = 112/269 (41%), Gaps = 67/269 (24%)

Query: 301  ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
            A+N   C C  +  GDSC +C PGF++     G FL +  C  C CHG ++ C       
Sbjct: 1825 ASNVELCLCPASYRGDSCQECAPGFYRDV--KGLFLGR--CVPCQCHGHSDRC------- 1873

Query: 361  RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCD--- 417
                         G GVC++C  NT G +CE C  GF   +    +   PC  C C    
Sbjct: 1874 -----------LPGSGVCVDCQHNTEGAHCERCQAGFVSSR---DDPSAPCVSCPCPLSV 1919

Query: 418  PIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP-----DCKACNCS 472
            P  +  E CV      R G     C CK G+ G SC+RCA G+ G P      C+ C+CS
Sbjct: 1920 PSNNFAEGCV-----LRGGRT--QCLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCS 1972

Query: 473  GLGSKNE-----DPCFGPCI-CKENVEGGDCSRCKSGFFN--LQEDNWKGCD-------- 516
            G G  N      DP  G C  C  +  G  C  C  GF+   L   N   CD        
Sbjct: 1973 GNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFYGNALLPGNCTRCDCTPCGTEA 2032

Query: 517  ------ECFC-SGVS----NRCQSSYWTY 534
                   C C +GV+    +RCQ  ++ +
Sbjct: 2033 CDPHSGHCLCKAGVTGRRCDRCQEGHFGF 2061



 Score =  116 bits (290), Expect = 4e-25
 Identities = 67/219 (30%), Positives = 88/219 (40%), Gaps = 48/219 (21%)

Query: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
           RC C+    G  CD+C PG+H  P           C+AC C  +                
Sbjct: 604 RCLCQPEFAGPHCDRCRPGYHGFP----------NCQACTCDPRGA-------------- 639

Query: 366 LNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEV 425
                +  G G    C     G  C+ C+ GF         +P  C PCHC   GSL+  
Sbjct: 640 ---LDQLCGAGGLCRCRPGYTGTACQECSPGFH-------GFPS-CVPCHCSAEGSLHAA 688

Query: 426 CVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFG- 484
           C  D +        G C C+    G+ CD C  G   +P C+A +C   G    DP    
Sbjct: 689 C--DPRS-------GQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPE 739

Query: 485 ---PCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
              PC+C+ +VEG  C RCK GF+ L   N +GC  C C
Sbjct: 740 AQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSC 778



 Score =  113 bits (283), Expect = 3e-24
 Identities = 68/188 (36%), Positives = 85/188 (45%), Gaps = 39/188 (20%)

Query: 1377 IEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNG---HSSLCDPET 1433
            + +C C   + G  CE C PGFY           GP    C PCQC+        CDP+T
Sbjct: 512  VGRCLCKPNFQGTHCELCAPGFY-----------GP---GCQPCQCSSPGVADDRCDPDT 557

Query: 1434 SICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPS-CVAEGLDDY 1492
              C+ C+    G  C+RCA GY+         CQ C C         SP+  + EG D+ 
Sbjct: 558  GQCR-CRVGFEGATCDRCAPGYFHFPL-----CQLCGC---------SPAGTLPEGCDEA 602

Query: 1493 RCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGA 1552
                C   + G +C+RC PGY G P     +CQ C CDP G+L   C    G C CRPG 
Sbjct: 603  GRCLCQPEFAGPHCDRCRPGYHGFP-----NCQACTCDPRGALDQLCG-AGGLCRCRPGY 656

Query: 1553 TGRKCDGC 1560
            TG  C  C
Sbjct: 657  TGTACQEC 664



 Score =  110 bits (276), Expect = 2e-23
 Identities = 66/185 (35%), Positives = 85/185 (45%), Gaps = 36/185 (19%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL---CDPETSI 1435
            +C C +G+ G +C+ C PG++                 C  C C+   +L   CD E   
Sbjct: 559  QCRCRVGFEGATCDRCAPGYFHFP-------------LCQLCGCSPAGTLPEGCD-EAGR 604

Query: 1436 CQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCT 1495
            C  CQ   AG  C+RC  GY+G     PN CQ C C    + +     C A GL      
Sbjct: 605  CL-CQPEFAGPHCDRCRPGYHGF----PN-CQACTCDPRGALDQL---CGAGGL-----C 650

Query: 1496 ACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGR 1555
             C  GY G  C+ C+PG+ G P     SC  C C   GSL   CDP +G C+CRP  TG 
Sbjct: 651  RCRPGYTGTACQECSPGFHGFP-----SCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGL 705

Query: 1556 KCDGC 1560
            +CD C
Sbjct: 706  RCDTC 710



 Score =  108 bits (270), Expect = 8e-23
 Identities = 73/247 (29%), Positives = 98/247 (39%), Gaps = 52/247 (21%)

Query: 296  CPLDPATN-----------KSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEAC 344
            CPL   +N           +++C C+    G SC++C PGF   P   G     + C+ C
Sbjct: 1915 CPLSVPSNNFAEGCVLRGGRTQCLCKPGYAGASCERCAPGFFGNPLVLG-----SSCQPC 1969

Query: 345  NCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVS 404
            +C G       D N+   +            G C  C ++T G  CE C  GF+     +
Sbjct: 1970 DCSGNG-----DPNLLFSDCDPLT-------GACRGCLRHTTGPRCEICAPGFYG----N 2013

Query: 405  PNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP 464
               P  C  C C P G+  E C   + H+      G C CK G  G  CDRC  G+ G+ 
Sbjct: 2014 ALLPGNCTRCDCTPCGT--EAC---DPHS------GHCLCKAGVTGRRCDRCQEGHFGFD 2062

Query: 465  DCKACNCSGLGSKNE----DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
             C  C     G   E     P  G C C+    G  C  C  G++ L E   +GC  C C
Sbjct: 2063 GCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPE---QGCRRCQC 2119

Query: 521  SGVSNRC 527
             G   RC
Sbjct: 2120 PG--GRC 2124



 Score =  101 bits (252), Expect = 1e-20
 Identities = 81/287 (28%), Positives = 102/287 (35%), Gaps = 95/287 (33%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC--DPETS-- 1434
            +C C     G +C+ C PGF     QP       +   C  C C GH++ C  DPE    
Sbjct: 321  QCTCQHNTCGGTCDRCCPGF---NQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRR 377

Query: 1435 --------------ICQNCQHHTAGDFCERCALGYYGIVK---GLPNDCQQCAC------ 1471
                          +C +CQHHT G  CERC  G+Y         P+ C++C C      
Sbjct: 378  RASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTD 437

Query: 1472 -----------------------------------PLISSSNN-----------FSPSCV 1485
                                               P  SSSN+            +  C 
Sbjct: 438  GTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCS 497

Query: 1486 AEGLDDYRCTACPR--------GYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPV 1537
            A G     C   PR         ++G +CE CAPG+ G    PG  CQ C+C   G    
Sbjct: 498  AAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYG----PG--CQPCQCSSPGVADD 551

Query: 1538 PCDPVTGFCTCRPGATGRKCDGCK--HWHAREGWECVFCGDECTGLL 1582
             CDP TG C CR G  G  CD C   ++H      C  CG    G L
Sbjct: 552  RCDPDTGQCRCRVGFEGATCDRCAPGYFHFP---LCQLCGCSPAGTL 595



 Score =  100 bits (250), Expect = 2e-20
 Identities = 62/189 (32%), Positives = 79/189 (41%), Gaps = 33/189 (17%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL---CDPETSIC 1436
            C C  GY+G +C+ C PGF+   S             CVPC C+   SL   CDP +  C
Sbjct: 650  CRCRPGYTGTACQECSPGFHGFPS-------------CVPCHCSAEGSLHAACDPRSGQC 696

Query: 1437 QNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCA-CPLISSSNNFSPSCVAEGLDDYRCT 1495
             +C+    G  C+ C  G Y         C      P+  +       C+          
Sbjct: 697  -SCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCM---------- 745

Query: 1496 ACPRGYEGQYCERCAPGYTG-SPGNPGGSCQECECDPYGSLP--VPCDPVTGFCTCRPGA 1552
             C    EG  C+RC PG+ G SP NP G C  C CD  G+L     C P TG C C+P  
Sbjct: 746  -CRAHVEGPSCDRCKPGFWGLSPSNPEG-CTRCSCDLRGTLGGVAECQPGTGQCFCKPHV 803

Query: 1553 TGRKCDGCK 1561
             G+ C  CK
Sbjct: 804  CGQACASCK 812



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 68/200 (34%), Positives = 84/200 (42%), Gaps = 34/200 (17%)

Query: 1375 DLIEKCDCPLGYSGLSCEACLPGFYRLRS-QPGGRTPGPT------LGTCVPCQCN---- 1423
            DL  +C C   +SG  C+ C  GF    S  P   +   T       G  V C C+    
Sbjct: 442  DLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGT 501

Query: 1424 -GHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSP 1482
             G++   DP    C  C+ +  G  CE CA G+YG        CQ C C         SP
Sbjct: 502  QGNACRKDPRVGRCL-CKPNFQGTHCELCAPGFYG------PGCQPCQCS--------SP 546

Query: 1483 SCVAEGLD-DYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDP 1541
                +  D D     C  G+EG  C+RCAPGY   P      CQ C C P G+LP  CD 
Sbjct: 547  GVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFP-----LCQLCGCSPAGTLPEGCDE 601

Query: 1542 VTGFCTCRPGATGRKCDGCK 1561
              G C C+P   G  CD C+
Sbjct: 602  -AGRCLCQPEFAGPHCDRCR 620



 Score = 85.5 bits (210), Expect = 7e-16
 Identities = 51/163 (31%), Positives = 73/163 (44%), Gaps = 23/163 (14%)

Query: 1420 CQCNGHSSLCDPET-----SICQNCQHHTAGDFCERCALGY-----YGIVKGLPNDCQQC 1469
            C C+GH+  CD +       +   CQH+T G  C+RC  G+             N+CQ C
Sbjct: 300  CVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSC 359

Query: 1470 ACPLISSSNNFSPSC----VAEGLD-DYR----CTACPRGYEGQYCERCAPGYTGSPGNP 1520
             C   ++   + P       ++ LD  Y+    C  C     G  CERC PG+  SP +P
Sbjct: 360  NCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHP 419

Query: 1521 GGS---CQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
              S   C+ C C+        C+ +TG C CRP  +G +CD C
Sbjct: 420  LDSPHVCRRCNCES-DFTDGTCEDLTGRCYCRPNFSGERCDVC 461



 Score = 79.0 bits (193), Expect = 7e-14
 Identities = 61/245 (24%), Positives = 88/245 (35%), Gaps = 46/245 (18%)

Query: 290 YGHARACPLDPATNKSR-------CECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECE 342
           + + +AC  DP     +       C C     G +C +C PGFH  P       +     
Sbjct: 626 FPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSL 685

Query: 343 ACNCHGKAEECYYDENVARRNLSLNIRGKY----IGGGVC------------------IN 380
              C  ++ +C     V        + G Y       G C                    
Sbjct: 686 HAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCM 745

Query: 381 CTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPG 440
           C  +  G +C+ C  GF+   G+SP+ P  C  C CD  G+L  V       A      G
Sbjct: 746 CRAHVEGPSCDRCKPGFW---GLSPSNPEGCTRCSCDLRGTLGGV-------AECQPGTG 795

Query: 441 SCHCKTGFGGVSCDRCARGYTG-----YPDCKACNCSGLGSKNE--DPCFGPCICKENVE 493
            C CK    G +C  C  G+ G     Y  C++C C   G+  +  +P  G C C+ N +
Sbjct: 796 QCFCKPHVCGQACASCKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQ 855

Query: 494 GGDCS 498
           G  CS
Sbjct: 856 GPTCS 860



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 38/116 (32%), Positives = 49/116 (42%), Gaps = 14/116 (12%)

Query: 407  YPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDC 466
            Y    +PC C  +G+    C             G C C     G  C RCA GY G+P+C
Sbjct: 1431 YNNGARPCGCHEVGATGPTCEP---------FGGQCPCHAHVIGRDCSRCATGYWGFPNC 1481

Query: 467  KACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSG 522
            + C+C   G++  D   G CIC       DC  C+   F        GC+EC CSG
Sbjct: 1482 RPCDC---GARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHP--LVGCEECNCSG 1532



 Score = 62.4 bits (150), Expect = 7e-09
 Identities = 49/189 (25%), Positives = 62/189 (32%), Gaps = 47/189 (24%)

Query: 1014 CECSHLGNNCDPKTG------RCICPPNTIGEKCSKCAP----NTWGHSITTG---CKAC 1060
            C C    + CD K        +C C  NT G  C +C P      W  +       C++C
Sbjct: 300  CVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSC 359

Query: 1061 NC----------------STVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPR-- 1102
            NC                    SLD          +C    +G  C  C  G +  P   
Sbjct: 360  NCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHP 419

Query: 1103 ------CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLD 1156
                  C  C+C    TD T          C D TG+C C+ N  G  CD C  G  G  
Sbjct: 420  LDSPHVCRRCNCESDFTDGT----------CEDLTGRCYCRPNFSGERCDVCAEGFTGFP 469

Query: 1157 AKNPLGCSS 1165
            +  P   SS
Sbjct: 470  SCYPTPSSS 478



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 36/138 (26%), Positives = 45/138 (32%), Gaps = 43/138 (31%)

Query: 287  CICYGHARACPLDPA--TNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEAC 344
            C C G       DP   T+  +C+C  N  G  CD C PGFH  P           C  C
Sbjct: 1528 CNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP----------RCRPC 1577

Query: 345  NCHGKAEECYYDENVARRNLSLNIRGKYIGGGVC------INCTQNTAGINCETCTDGFF 398
            +CH                            GVC        C +N  G  C+ C+ G F
Sbjct: 1578 DCHEAG----------------------TAPGVCDPLTGQCYCKENVQGPKCDQCSLGTF 1615

Query: 399  RPKGVSPNYPRPCQPCHC 416
                +    P+ C  C C
Sbjct: 1616 ---SLDAANPKGCTRCFC 1630



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 36/125 (28%), Positives = 47/125 (37%), Gaps = 19/125 (15%)

Query: 1446 DFCERCAL-GYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYE-- 1502
            DF   CA  GY+         C+  A  L    NN +  C    +     T  P G +  
Sbjct: 1399 DFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCP 1458

Query: 1503 ------GQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556
                  G+ C RCA GY G P     +C+ C+C         CD +TG C C P      
Sbjct: 1459 CHAHVIGRDCSRCATGYWGFP-----NCRPCDCGAR-----LCDELTGQCICPPRTIPPD 1508

Query: 1557 CDGCK 1561
            C  C+
Sbjct: 1509 CLLCQ 1513



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 25/68 (36%), Positives = 27/68 (39%), Gaps = 11/68 (16%)

Query: 1118 CDSETKKCSCSDQTG----QCTCKVNVEGIHCDRCRPGKFGLDAKNPL------GCSSCY 1167
            C      C   D T     QCTC+ N  G  CDRC PG F      P        C SC 
Sbjct: 302  CHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPG-FNQQPWKPATANSANECQSCN 360

Query: 1168 CFGTTTQC 1175
            C+G  T C
Sbjct: 361  CYGHATDC 368



 Score = 39.7 bits (91), Expect = 0.047
 Identities = 18/63 (28%), Positives = 29/63 (46%), Gaps = 2/63 (3%)

Query: 467  KACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVS 524
            + C C  +G+     +P  G C C  +V G DCSRC +G++         C    C  ++
Sbjct: 1436 RPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELT 1495

Query: 525  NRC 527
             +C
Sbjct: 1496 GQC 1498



 Score = 38.9 bits (89), Expect = 0.080
 Identities = 35/135 (25%), Positives = 45/135 (33%), Gaps = 38/135 (28%)

Query: 291  GHARACPLDPATNKS-------RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEA 343
            G  R C   PA   S       +C C   T G  C +C PG+    W     L +  C  
Sbjct: 2065 GGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGY----WG----LPEQGCRR 2116

Query: 344  CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGV 403
            C C G    C  D +  R                  NC    +G  C+TC+     P   
Sbjct: 2117 CQCPG--GRC--DPHTGR-----------------CNCPPGLSGERCDTCSQQHQVPVPG 2155

Query: 404  SP-NYPRPCQPC-HC 416
             P  +   C+ C HC
Sbjct: 2156 GPVGHSIHCEVCDHC 2170


>gi|38045908 laminin alpha 3 subunit isoform 2 [Homo sapiens]
          Length = 1724

 Score =  430 bits (1105), Expect = e-119
 Identities = 459/1808 (25%), Positives = 759/1808 (41%), Gaps = 221/1808 (12%)

Query: 1392 EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAGDFCERC 1451
            + C PG+YR          G   G CVPC CNGHS+ C   + IC NCQH+TAG+ CERC
Sbjct: 57   QGCSPGYYRDHK-------GLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERC 109

Query: 1452 ALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAP 1511
              GYYG    +   C+ C CP    +N+F+  CV  G  D RC +C  GY G  CERCAP
Sbjct: 110  QEGYYG--NAVHGSCRACPCP---HTNSFATGCVVNG-GDVRC-SCKAGYTGTQCERCAP 162

Query: 1512 GYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFC---TCRPGATGRKCDGCKHWHAREG 1568
            GY G+P   GGSCQ C C+  G L   C P+TG C     +  +   +CD C        
Sbjct: 163  GYFGNPQKFGGSCQPCSCNSNGQLG-SCHPLTGDCINQEPKDSSPAEECDDC-------- 213

Query: 1569 WECVFCGDECTGLLLGDLARL-EQMVMSINLTGPLPAPYKMLYGLENMTQELK----HLL 1623
                   D C   LL DLA + EQ+ +  +    L A   +L  + +M  + K     LL
Sbjct: 214  -------DSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLL 266

Query: 1624 SPQRAPERLIQLAEGNLNTLVTEMN---ELLTRATKVTADGEQT-GQDAERTNTRAKSLG 1679
            + + A        EG L   +T++N   E L    +V +   QT   +  R    AK L 
Sbjct: 267  NYRSAISNHGSKIEG-LERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELD 325

Query: 1680 EFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEI 1739
              IK + R+   + +   +++ T G  +     +      E  +M++ELR +N       
Sbjct: 326  VKIKNVIRNVHILLK---QISGTDGEGNNVPSGDFSREWAEAQRMMRELRNRNFGKHLRE 382

Query: 1740 AEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIRE 1799
            AE +   ++ LL +++      +GEN  +   +R+ L +Y+ K+ D    L+EA  + ++
Sbjct: 383  AEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQ 442

Query: 1800 ANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDI 1859
            AN L   N++ + A++++ + + S +      L   +  L + N     +       E +
Sbjct: 443  ANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKL 502

Query: 1860 QTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAK--NI 1917
               L    +EL+DK+ +LS+      L E   +AE HA  L + +  L+ I   A    +
Sbjct: 503  AASLNEARQELSDKVRELSRSAGKTSLVE---EAEKHARSLQELAKQLEEIKRNASGDEL 559

Query: 1918 SFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRI 1977
               A  A  AY NI + I  AE  A  A   +  A  L T  +  L   AK     S ++
Sbjct: 560  VRCAVDAATAYENILNAIKAAEDAANRAASASESA--LQTVIKEDLPRKAKTLSSNSDKL 617

Query: 1978 LNEAKKLANDVK-ENEDHLNGLKTRIENADARNGDL---LRTLNDTLGKLSAIPNDTAAK 2033
            LNEAK     +K E    LN L+  +     +   +   L TL D L  +     D  A 
Sbjct: 618  LNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQR--GDIDAM 675

Query: 2034 LQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIA 2093
            + + K   R+AND   +VL  +  +  +++ +K  Y +  +   K           K + 
Sbjct: 676  ISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFK-----------KALT 724

Query: 2094 DADATVKNLEQEADRLIDKLKPIKEL---EDNLKKNISEIKELINQARKQANSIKVSV-- 2148
            DAD +V  L  +   L  K++ I +      N+  N+  I+ELI QAR  A+ + V +  
Sbjct: 725  DADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRF 784

Query: 2149 --SSGGDCIRTYKPEIKKGSYNNIVVNVKT-------AVADNLLFYLGSAKFI-DFLAIE 2198
               SG +       E  KG Y ++ + ++           +  + YLG+     D++ + 
Sbjct: 785  NGKSGVEVRLPNDLEDLKG-YTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMA 843

Query: 2199 MRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASI--- 2255
            +  G+++ ++++G     ++  D  +  S     V  R           L+  K +    
Sbjct: 844  VVDGQLTCVYNLGDREAELQV-DQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSK 902

Query: 2256 --VPSTHHSTSPPGYTILDVD-ANAMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKP 2312
               P  +        T+L++D  N + +VGG     K    +    + GC+     +   
Sbjct: 903  PETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENV 962

Query: 2313 IGLWNFREKEGDCKGCTVSP---QVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFR 2369
            + L+NF+ K  +     V P   + E+S+    F+G GYA V  P + +  I T     +
Sbjct: 963  LSLYNFK-KTFNLNTTEVEPCRRRKEESDKN-YFEGTGYARV--PTQPHAPIPTFGQTIQ 1018

Query: 2370 TFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGS------GMASVVSNQNHNDGKWK 2423
            T     LL +    D   F+S+ + DG + V Y L S      G+   ++N   +  + K
Sbjct: 1019 TTVDRGLLFFAENGD--RFISLNIEDGKLMVRYKLNSELPKERGVGDAINNGRDHSIQIK 1076

Query: 2424 SFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKA 2483
               + ++QK+  I+ VD+         T   G  F          Y GG+P    ++++ 
Sbjct: 1077 ---IGKLQKRMWIN-VDVQN-------TIIDGEVFDF-----STYYLGGIP----IAIRE 1116

Query: 2484 RPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCS--LENVYTVSFPKPG---FVE 2538
            R  ++   + GC+K++   +    ++   D VGVTK CS   + V + SF + G   F +
Sbjct: 1117 RFNISTPAFRGCMKNL---KKTSGVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLSFTD 1173

Query: 2539 LSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVH 2598
            L   P D   + +  F T   SGI+L               QT      + L  G +E+ 
Sbjct: 1174 LGLPPTD-HLQASFGFQTFQPSGILL-------------DHQTWTRNLQVTLEDGYIELS 1219

Query: 2599 LSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDE----NRRYMQNLTVEQP 2654
             S     + K      P  + DG  H V V        + +D+    N + +++++  + 
Sbjct: 1220 TSDSGSPIFK-----SPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKRLKHISSSR- 1273

Query: 2655 IEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVP-----MDFARPVSFKNADIGR 2709
               + L +GG+              FEGCI N+ +  +      +D       ++  +G 
Sbjct: 1274 ---QSLRLGGS-------------NFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGG 1317

Query: 2710 CAHQK----------LREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPAL 2759
            C+  K           R ++        ++Q  PV +P     +  +    C+   +   
Sbjct: 1318 CSLNKPPFLMLLKGSTRFNKTKTFRINQLLQDTPVASPR----SVKVWQDACSPLPKTQA 1373

Query: 2760 LIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLR 2819
              G+ QFG    SH+        +K R    ++++T +  GL+F+    N   F  + L 
Sbjct: 1374 NHGALQFGDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTGTKN--SFMALYLS 1431

Query: 2820 NGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADIL 2879
             G   F+              K NDG+WH +      ++G L VDG   R  S      +
Sbjct: 1432 KGRLVFALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTI 1491

Query: 2880 DVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-A 2938
             +   +Y+G  P   + +     T S  GC++N  +   P  L  P+SSF V +C     
Sbjct: 1492 SIRAPVYLGSPP---SGKPKSLPTNSFVGCLKNFQLDSKP--LYTPSSSFGVSSCLGGPL 1546

Query: 2939 QRGTYF-DGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKL 2997
            ++G YF +  G         +G +  + F  R  + TG+L+ I SQ    + + +   K+
Sbjct: 1547 EKGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQPGKHLCVYLEAGKV 1606

Query: 2998 MFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKH--RIELTVDGNQVEAQSPNPAS 3055
               +D+GAG  +          LCDGQWH V     +H   +EL  D +    Q P P  
Sbjct: 1607 TASMDSGAGGTST--SVTPKQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAGQIPFP-- 1662

Query: 3056 TSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQ 3115
              A T +P+ +GG P +L    +     F GC+R++ +       + V   +ALE++G  
Sbjct: 1663 -PASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNH-----IPVPVTEALEVQG-- 1714

Query: 3116 PVS---CP 3120
            PVS   CP
Sbjct: 1715 PVSLNGCP 1722



 Score =  139 bits (349), Expect = 6e-32
 Identities = 66/168 (39%), Positives = 94/168 (55%), Gaps = 13/168 (7%)

Query: 736 ESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGE 795
           + C P + R +  ++ G C PC C GH+  C D +G C+NC+ +T G +C++C  G+YG 
Sbjct: 57  QGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGN 116

Query: 796 PTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQP 855
              G+   C+ C CP    +N+F+  C ++   G +   C  GYTG +CERCA GYFG P
Sbjct: 117 AVHGS---CRACPCP---HTNSFATGCVVNG--GDVRCSCKAGYTGTQCERCAPGYFGNP 168

Query: 856 SVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP--GTTGRYCELC 901
              GGSCQPC CN N      GSC  L+G C+  +P   +    C+ C
Sbjct: 169 QKFGGSCQPCSCNSNGQL---GSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 54/161 (33%), Positives = 77/161 (47%), Gaps = 14/161 (8%)

Query: 847 CAEGYF-GQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGY 905
           C+ GY+     +  G C PC CN + +      C   SG C+ C+  T G +CE C +GY
Sbjct: 59  CSPGYYRDHKGLYTGRCVPCNCNGHSN-----QCQDGSGICVNCQHNTAGEHCERCQEGY 113

Query: 906 FGDAVDAKNCQPCRCNAGGSFSEVCHSQTG--QCECRANVQGQRCDKCKAGTFGLQSARG 963
           +G+AV   +C+ C C    SF+  C    G  +C C+A   G +C++C  G FG     G
Sbjct: 114 YGNAVHG-SCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFG 172

Query: 964 --CVPCNCNSFGSKSFDCEESGQCWCQ---PGVTGKKCDRC 999
             C PC+CNS G        +G C  Q        ++CD C
Sbjct: 173 GSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 91.7 bits (226), Expect = 1e-17
 Identities = 52/158 (32%), Positives = 74/158 (46%), Gaps = 17/158 (10%)

Query: 901  CADGYFGD--AVDAKNCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQGQRCDKCKAGTFG 957
            C+ GY+ D   +    C PC CN     S  C   +G C  C+ N  G+ C++C+ G +G
Sbjct: 59   CSPGYYRDHKGLYTGRCVPCNCNG---HSNQCQDGSGICVNCQHNTAGEHCERCQEGYYG 115

Query: 958  LQSARGCVPCNCNSFGSKSFDCEESG---QCWCQPGVTGKKCDRCAHGYFNFQE---GGC 1011
                  C  C C    S +  C  +G   +C C+ G TG +C+RCA GYF   +   G C
Sbjct: 116  NAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSC 175

Query: 1012 TACECSHLG--NNCDPKTGRCI---CPPNTIGEKCSKC 1044
              C C+  G   +C P TG CI      ++  E+C  C
Sbjct: 176  QPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 58/199 (29%), Positives = 79/199 (39%), Gaps = 43/199 (21%)

Query: 321 CCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCIN 380
           C PG++    R    L    C  CNC+G + +C                    G G+C+N
Sbjct: 59  CSPGYY----RDHKGLYTGRCVPCNCNGHSNQCQD------------------GSGICVN 96

Query: 381 CTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPG 440
           C  NTAG +CE C +G++            C+ C C    S    CV +    R      
Sbjct: 97  CQHNTAGEHCERCQEGYY-----GNAVHGSCRACPCPHTNSFATGCVVNGGDVR------ 145

Query: 441 SCHCKTGFGGVSCDRCARGYTGYP-----DCKACNCSGLGSKNE-DPCFGPCICKENVEG 494
            C CK G+ G  C+RCA GY G P      C+ C+C+  G      P  G CI +E  + 
Sbjct: 146 -CSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 204

Query: 495 G---DCSRCKSGFFNLQED 510
               +C  C S    L  D
Sbjct: 205 SPAEECDDCDSCVMTLLND 223



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 47/160 (29%), Positives = 72/160 (45%), Gaps = 15/160 (9%)

Query: 999  CAHGYFNFQEG----GCTACECSHLGNNCDPKTGRCI-CPPNTIGEKCSKCAPNTWGHSI 1053
            C+ GY+   +G     C  C C+   N C   +G C+ C  NT GE C +C    +G+++
Sbjct: 59   CSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAV 118

Query: 1054 TTGCKACNCSTVGSLDFQCNVNTG--QCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLP 1111
               C+AC C    S    C VN G  +C+C   ++G +C  C+ G++  P+      F  
Sbjct: 119  HGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQ-----KFGG 173

Query: 1112 GTDATTCDSETKKCSCSDQTGQC---TCKVNVEGIHCDRC 1148
                 +C+S  +  SC   TG C     K +     CD C
Sbjct: 174  SCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 62.0 bits (149), Expect = 9e-09
 Identities = 37/119 (31%), Positives = 49/119 (41%), Gaps = 14/119 (11%)

Query: 1054 TTGCKACNCSTVGSLDFQCNVNTGQC-NCHPKFSGAKCTECSRGHWN---YPRCNLCDCF 1109
            T  C  CNC+   +   QC   +G C NC    +G  C  C  G++    +  C  C C 
Sbjct: 72   TGRCVPCNCNGHSN---QCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPC- 127

Query: 1110 LPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC 1168
             P T+     S    C  +    +C+CK    G  C+RC PG FG   K    C  C C
Sbjct: 128  -PHTN-----SFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSC 180



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 48/180 (26%), Positives = 62/180 (34%), Gaps = 54/180 (30%)

Query: 274 YYYSVKDISVGGM--CICYGHARACPLDPATNKSRC-ECEHNTCGDSCDQCCPGFHQKPW 330
           YY   K +  G    C C GH+  C          C  C+HNT G+ C++C  G++    
Sbjct: 63  YYRDHKGLYTGRCVPCNCNGHSNQCQ----DGSGICVNCQHNTAGEHCERCQEGYYGN-- 116

Query: 331 RAGTFLTKTECEACNC---HGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAG 387
                     C AC C   +  A  C  +                 GG V  +C     G
Sbjct: 117 -----AVHGSCRACPCPHTNSFATGCVVN-----------------GGDVRCSCKAGYTG 154

Query: 388 INCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTG 447
             CE C  G+F   G    +   CQPC C+  G L                 GSCH  TG
Sbjct: 155 TQCERCAPGYF---GNPQKFGGSCQPCSCNSNGQL-----------------GSCHPLTG 194



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 30/69 (43%), Positives = 37/69 (53%), Gaps = 5/69 (7%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQC--FGHAESCDDVTGECLN--CKDH 779
           C C  GYTG+ CE C P +   N   FGG C+PC C   G   SC  +TG+C+N   KD 
Sbjct: 146 CSCKAGYTGTQCERCAPGYFG-NPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 204

Query: 780 TGGPYCDKC 788
           +    CD C
Sbjct: 205 SPAEECDDC 213



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 49/180 (27%), Positives = 69/180 (38%), Gaps = 32/180 (17%)

Query: 393 CTDGFFRP-KGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC-HCKTGFGG 450
           C+ G++R  KG+   Y   C PC+C+  G  N+   +D          G C +C+    G
Sbjct: 59  CSPGYYRDHKGL---YTGRCVPCNCN--GHSNQC--QD--------GSGICVNCQHNTAG 103

Query: 451 VSCDRCARGYTG---YPDCKACNCSGLGSKNEDPCFGP----CICKENVEGGDCSRCKSG 503
             C+RC  GY G   +  C+AC C    S             C CK    G  C RC  G
Sbjct: 104 EHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPG 163

Query: 504 FFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMSGWYLTDLPGRIRVAPQQDDLDS 563
           +F   +     C  C C        +S    G    ++G  +   P     A + DD DS
Sbjct: 164 YFGNPQKFGGSCQPCSC--------NSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDS 215



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 23/99 (23%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL--CDPETSIC 1436
            +C C  GY+G  CE C PG++          P    G+C PC CN +  L  C P T  C
Sbjct: 145  RCSCKAGYTGTQCERCAPGYF--------GNPQKFGGSCQPCSCNSNGQLGSCHPLTGDC 196

Query: 1437 QNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLIS 1475
             N Q        E C            +DC  C   L++
Sbjct: 197  IN-QEPKDSSPAEEC------------DDCDSCVMTLLN 222



 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 40/131 (30%), Positives = 49/131 (37%), Gaps = 24/131 (18%)

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRT-PGP-TLGTCVPCQCNGHSSLCDPETSICQN 1438
            +C    +G  CE C  G+Y        R  P P T      C  NG    C        +
Sbjct: 96   NCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRC--------S 147

Query: 1439 CQHHTAGDFCERCALGYYGIVKGLPNDCQQCAC----------PLISSSNNFSP--SCVA 1486
            C+    G  CERCA GY+G  +     CQ C+C          PL     N  P  S  A
Sbjct: 148  CKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPA 207

Query: 1487 EGLDDYRCTAC 1497
            E  DD  C +C
Sbjct: 208  EECDD--CDSC 216


>gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
          Length = 1816

 Score =  421 bits (1082), Expect = e-117
 Identities = 452/1862 (24%), Positives = 780/1862 (41%), Gaps = 227/1862 (12%)

Query: 1384 LGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHT 1443
            LG    + E C  GF+   S           G CVPC CNG+S+ C   +  C +CQ +T
Sbjct: 57   LGRLPPAAEKCNAGFFHTLS-----------GECVPCDCNGNSNECLDGSGYCVHCQRNT 105

Query: 1444 AGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYE 1502
             G+ CE+C  GY G  ++G P  CQ C CPL   +N F+ SC  +     RC  C   Y 
Sbjct: 106  TGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLAN-FAESCYRKN-GAVRCI-CNENYA 162

Query: 1503 GQYCERCAPGYTGSPGNPGGSCQECEC----DPYGSLPVPCDPVTGFC-TCRPGATGRKC 1557
            G  CERCAPGY G+P   G +C++C+C    DP   +   CD VTG C  C    TG KC
Sbjct: 163  GPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDP-NLIFEDCDEVTGQCRNCLRNTTGFKC 221

Query: 1558 DGCK---HWHAREGWECVFCG------DECTGLLLG-----------------DLARLEQ 1591
            + C    +  AR    C  C       D  TG  L                  D  RL  
Sbjct: 222  ERCAPGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFEPPTGCDKCVWDLTDALRLAA 281

Query: 1592 MVMSINLTGPLP-----APYKMLYGLENMTQELKHLLSPQRAPERL----IQLAEGNLNT 1642
            + +    +G L      A ++ +  +      LK  LS +     L    I  AE  + +
Sbjct: 282  LSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYALRKIQINNAENTMKS 341

Query: 1643 LVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNET 1702
            L++++ EL+ +  + +  G+   +++  T   A  L E   ++    + +N K +   E 
Sbjct: 342  LLSDVEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNKMLYYGEE 401

Query: 1703 LGTRDEAFERNLEGLQKEIDQMIKELR-RKNLETQKEIAEDELVAAEALLKKVKKLFGES 1761
                 +     L   QK    M++E+R R+   TQ+E+ ++E   A  LL + +  +   
Sbjct: 402  HELSPKEISEKLVLAQK----MLEEIRSRQPFFTQRELVDEEADEAYELLSQAES-WQRL 456

Query: 1762 RGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA---NRLFAVNQKNMTALEKKK 1818
              E   +   + E+L DY  K+ D  + L +A + +R+A   NR  A  Q++    EK++
Sbjct: 457  HNETRTLFPVVLEQLDDYNAKLSDLQEALDQALNYVRDAEDMNRATAARQRDH---EKQQ 513

Query: 1819 EAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLS 1878
            E V      +  +L    D L        E++ II     I  ++     EL  K+ +LS
Sbjct: 514  ERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQVKLSNLS 573

Query: 1879 QEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSNIKDYIDEA 1938
                D  + E +  A+    + N+ S  L     +   +   A  A   Y NI +Y+ EA
Sbjct: 574  NLSHDL-VQEAIDHAQDLQQEANELSRKLHS--SDMNGLVQKALDASNVYENIVNYVSEA 630

Query: 1939 EKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDH-LNG 1997
             + A+ A +         +G    +         +S  +LN+A++L    + + D  +  
Sbjct: 631  NETAEFALNTTDRIYDAVSG----IDTQIIYHKDESENLLNQARELQAKAESSSDEAVAD 686

Query: 1998 LKTRIENADARNGDLLRTLNDTLGKLSAIPN-DTAAKLQAVKDKARQANDTAKDVLAQIT 2056
               R+  A AR   L   L+D + +L A    D   +L   +    +AN T  +V     
Sbjct: 687  TSRRVGGALARKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTMEVQQATA 746

Query: 2057 ELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPI 2116
             +  NL    +N      S           + N  +  A   V+NL +   +L+D+L+ +
Sbjct: 747  PMANNLTNWSQNLQHFDSS-----------AYNTAVNSARDAVRNLTEVVPQLLDQLRTV 795

Query: 2117 KELE--DNLKKNISEIKELINQARKQANSIKVSVSSGGDCI-----RTYKPEIKKGSYNN 2169
            ++     N+  +I  I+ELI Q R  A+ I+VS+   G        RT   ++K  ++ +
Sbjct: 796  EQKRPASNVSASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDLK--AFTS 853

Query: 2170 IVVNVK--------TAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYP 2220
            + + +K        T  AD  + YLGS     +++ + ++   + +++++G+    +   
Sbjct: 854  LSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIPLD 913

Query: 2221 DLTIDD--SYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDA-NA 2277
               +    +Y+  +   R G++G + +        +              ++LD+D  + 
Sbjct: 914  SKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDT 973

Query: 2278 MLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDS 2337
            + +VGG+    K   ++ +  F GC+     +N  I L+NF+         +V P   D 
Sbjct: 974  VFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYNFKHIYNMDPSTSV-PCARDK 1032

Query: 2338 EGTIQ-------FDGEGYALVSRPIRW--YPNISTVMFKFRTFSSSALLMYLATRDLRDF 2388
                Q       FDG GYA+V    R   +  ++    + RT + + L++ +    +  F
Sbjct: 1033 LAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSM--F 1090

Query: 2389 MSVELTDGHIKVSYDLG-SG----MASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDT 2443
              +E+ +G++ V YD G SG    +   +     ND K+   ++     +  I +VD   
Sbjct: 1091 FRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVD--- 1147

Query: 2444 NQEENIATSSSGNNFGLDLKADDKIYFGGLPT--LRNLSMKARPEVNLKKYSGCLKDIEI 2501
                ++    S +N  + +   D IY GG P   L++ +++A   +++  + GC+K  + 
Sbjct: 1148 --RRHV---KSMDNEKMKIPFTD-IYIGGAPPEILQSRALRAHLPLDIN-FRGCMKGFQF 1200

Query: 2502 SRTPYNILSSPDYVGVTKGCSLENVYT--VSFPKPGFV-ELSPVPIDVGTEINLSFSTKN 2558
             +  +N+L   + +GV  GC  +++ +    F    F+  +  +    G E   +F T  
Sbjct: 1201 QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQ 1260

Query: 2559 ESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLF 2618
             +G++   + G+               + I L+ G       T    ++ I ++     +
Sbjct: 1261 PNGLLFYYASGSDV-------------FSISLDNG-------TVIMDVKGIKVQSVDKQY 1300

Query: 2619 HDGREHSVHVERTRGIFTVQVDENRRYMQNLT---VEQP-IEVKKLFVGGAPPEFQPSPL 2674
            +DG  H V    +   + + VD++R   +N T   +EQ     KK + GG+P   Q +  
Sbjct: 1301 NDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYAN- 1359

Query: 2675 RNIPPFEGCIWNLVINSVPMD-----FARPVSFKNADIGRC------------------- 2710
                 F GCI N     V  D     F R     +  +  C                   
Sbjct: 1360 -----FTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSK 1414

Query: 2711 --AHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGL 2768
              A Q  +  +   AP+      +PV        TP  +H  C   + P  +  + Q+G 
Sbjct: 1415 PKASQNKKGGKSKDAPSW-----DPVALKLPERNTPRNSH--CHLSNSPRAIEHAYQYGG 1467

Query: 2769 SRNSHIAIAF--DDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFS 2826
            + NS         D   K++ +I L  RT +  G++FY++     DF T+ L +G   + 
Sbjct: 1468 TANSRQEFEHLKGDFGAKSQFSIRL--RTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYM 1525

Query: 2827 YDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGM 2884
            +++G          K NDG WH +  +R +  G L +DG      ++ P +A    + G 
Sbjct: 1526 FNVGHKKLKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEA-TWKIKGP 1584

Query: 2885 LYVGGLPINYTTRRIG-PVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-AQRGT 2942
            +Y+GG+      + +     YS  GC+ NL +    A +   + +F V  CF    + GT
Sbjct: 1585 IYLGGVAPGKAVKNVQINSIYSFSGCLSNLQL--NGASITSASQTFSVTPCFEGPMETGT 1642

Query: 2943 YFDGT-GFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHV 3001
            YF    G+      F +GL   + FE R  +++G L+   S   + + + M + +++  V
Sbjct: 1643 YFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKV 1702

Query: 3002 DNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSP-NPASTSADT 3060
            +NG   F+          LCDG+WH++T  +  + ++L VD        P NP     D 
Sbjct: 1703 NNGIRDFST--SVTPKQSLCDGRWHRITVIRDSNVVQLDVDSEVNHVVGPLNP--KPIDH 1758

Query: 3061 NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPV-SC 3119
             +PVFVGG P+ L    L  S PF GCIR   +    G P  V+F+KA  + G   + SC
Sbjct: 1759 REPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI---DGHP--VSFSKAALVSGAVSINSC 1813

Query: 3120 PA 3121
            PA
Sbjct: 1814 PA 1815



 Score =  175 bits (444), Expect = 6e-43
 Identities = 88/216 (40%), Positives = 117/216 (54%), Gaps = 12/216 (5%)

Query: 740 PRHRRVNGTIF---GGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEP 796
           P   + N   F    G C PC C G++  C D +G C++C+ +T G +C+KCL G+ G+ 
Sbjct: 62  PAAEKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 797 TKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPS 856
            +G  + CQPC CPL   + NF+ +C+  R  G +   C   Y GP CERCA GY+G P 
Sbjct: 122 IRGAPQFCQPCPCPLPHLA-NFAESCY--RKNGAVRCICNENYAGPNCERCAPGYYGNPL 178

Query: 857 VPGGSCQPCQCNDNLDFS-IPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNC 915
           + G +C+ C C+ N D + I   CD ++G C  C   TTG  CE CA GY+GDA  AKNC
Sbjct: 179 LIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNC 238

Query: 916 QPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKC 951
             C C  G      C S TG+C          CDKC
Sbjct: 239 AVCNCGGG-----PCDSVTGECLEEGFEPPTGCDKC 269



 Score =  132 bits (332), Expect = 5e-30
 Identities = 79/223 (35%), Positives = 106/223 (47%), Gaps = 25/223 (11%)

Query: 837  VGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGR 896
            +G   P  E+C  G+F   S   G C PC CN N +  + GS     G C+ C+  TTG 
Sbjct: 57   LGRLPPAAEKCNAGFFHTLS---GECVPCDCNGNSNECLDGS-----GYCVHCQRNTTGE 108

Query: 897  YCELCADGYFGDAVDA--KNCQPCRCNAG--GSFSEVCHSQTG--QCECRANVQGQRCDK 950
            +CE C DGY GD++    + CQPC C      +F+E C+ + G  +C C  N  G  C++
Sbjct: 109  HCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCER 168

Query: 951  CKAGTFG--LQSARGCVPCNCNSFGSKSF---DCEE-SGQCW-CQPGVTGKKCDRCAHGY 1003
            C  G +G  L     C  C+C+     +    DC+E +GQC  C    TG KC+RCA GY
Sbjct: 169  CAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGY 228

Query: 1004 FNFQE--GGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKC 1044
            +        C  C C   G  CD  TG C+         C KC
Sbjct: 229  YGDARIAKNCAVCNCG--GGPCDSVTGECLEEGFEPPTGCDKC 269



 Score =  110 bits (275), Expect = 2e-23
 Identities = 74/199 (37%), Positives = 98/199 (49%), Gaps = 30/199 (15%)

Query: 949  DKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQC-WCQPGVTGKKCDRCAHGYFNFQ 1007
            +KC AG F   S   CVPC+CN   ++  D   SG C  CQ   TG+ C++C  GY    
Sbjct: 65   EKCNAGFFHTLSGE-CVPCDCNGNSNECLD--GSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 1008 EGG----CTACECS--HLGN---NCDPKTG--RCICPPNTIGEKCSKCAPNTWGHSITTG 1056
              G    C  C C   HL N   +C  K G  RCIC  N  G  C +CAP  +G+ +  G
Sbjct: 122  IRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIG 181

Query: 1057 --CKACNCS--TVGSLDFQ-CNVNTGQC-NCHPKFSGAKCTECSRGHWNYPR----CNLC 1106
              CK C+CS  +  +L F+ C+  TGQC NC    +G KC  C+ G++   R    C +C
Sbjct: 182  STCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVC 241

Query: 1107 DCFLPGTDATTCDSETKKC 1125
            +C         CDS T +C
Sbjct: 242  NC-----GGGPCDSVTGEC 255



 Score =  102 bits (254), Expect = 6e-21
 Identities = 63/200 (31%), Positives = 87/200 (43%), Gaps = 26/200 (13%)

Query: 997  DRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCI-CPPNTIGEKCSKCAPNTWGHSITT 1055
            ++C  G+F+   G C  C+C+   N C   +G C+ C  NT GE C KC     G SI  
Sbjct: 65   EKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRG 124

Query: 1056 G---CKACNCSTVGSLDF--QCNVNTG--QCNCHPKFSGAKCTECSRGHWNYP-----RC 1103
                C+ C C      +F   C    G  +C C+  ++G  C  C+ G++  P      C
Sbjct: 125  APQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTC 184

Query: 1104 NLCDCFLPGTDATTCDSETKKCSCSDQTGQC-TCKVNVEGIHCDRCRPGKFGLDAKNPLG 1162
              CDC      +   D       C + TGQC  C  N  G  C+RC PG +G DA+    
Sbjct: 185  KKCDC------SGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYG-DARIAKN 237

Query: 1163 CSSCYCFG-----TTTQCSE 1177
            C+ C C G      T +C E
Sbjct: 238  CAVCNCGGGPCDSVTGECLE 257



 Score = 99.8 bits (247), Expect = 4e-20
 Identities = 76/261 (29%), Positives = 105/261 (40%), Gaps = 48/261 (18%)

Query: 332 AGTFLTKT-ECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINC 390
           AG F T + EC  C+C+G + EC                    G G C++C +NT G +C
Sbjct: 69  AGFFHTLSGECVPCDCNGNSNECLD------------------GSGYCVHCQRNTTGEHC 110

Query: 391 ETCTDGFFRPK-GVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449
           E C DG+       +P + +PC PC    + +  E C +     R       C C   + 
Sbjct: 111 EKCLDGYIGDSIRGAPQFCQPC-PCPLPHLANFAESCYRKNGAVR-------CICNENYA 162

Query: 450 GVSCDRCARGYTGYP-----DCKACNCSGLGSKNE-----DPCFGPC-ICKENVEGGDCS 498
           G +C+RCA GY G P      CK C+CSG    N      D   G C  C  N  G  C 
Sbjct: 163 GPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCE 222

Query: 499 RCKSGFFNLQEDNWKGCDECFCSG-----VSNRCQSSYWTYGKIQDMSGWYLTDLPGRIR 553
           RC  G++       K C  C C G     V+  C    +      D   W LTD    +R
Sbjct: 223 RCAPGYYG-DARIAKNCAVCNCGGGPCDSVTGECLEEGFEPPTGCDKCVWDLTD---ALR 278

Query: 554 VAPQQDDLDSPQQISISNAEA 574
           +A    +      +S+S+  A
Sbjct: 279 LAALSIEEGKSGVLSVSSGAA 299



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 34/92 (36%), Positives = 50/92 (54%), Gaps = 9/92 (9%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHA------ESCDDVTGECLNCK 777
           C C   Y G +CE C P +   N  + G  C+ C C G++      E CD+VTG+C NC 
Sbjct: 155 CICNENYAGPNCERCAPGYYG-NPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCL 213

Query: 778 DHTGGPYCDKCLPGFYGEPTKGTSEDCQPCAC 809
            +T G  C++C PG+YG+     +++C  C C
Sbjct: 214 RNTTGFKCERCAPGYYGDAR--IAKNCAVCNC 243



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 67/239 (28%), Positives = 91/239 (38%), Gaps = 58/239 (24%)

Query: 287 CICYGHARACPLDPATNKSRC-ECEHNTCGDSCDQCCPGFHQKPWR-AGTFLTKTECEAC 344
           C C G++  C LD       C  C+ NT G+ C++C  G+     R A  F     C   
Sbjct: 82  CDCNGNSNEC-LD---GSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLP 137

Query: 345 NCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVS 404
           +    AE CY      R+N           G V   C +N AG NCE C  G++   G  
Sbjct: 138 HLANFAESCY------RKN-----------GAVRCICNENYAGPNCERCAPGYY---GNP 177

Query: 405 PNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC-HCKTGFGGVSCDRCARGYTG- 462
                 C+ C C      N +    ++        G C +C     G  C+RCA GY G 
Sbjct: 178 LLIGSTCKKCDCSGNSDPNLIFEDCDE------VTGQCRNCLRNTTGFKCERCAPGYYGD 231

Query: 463 ---YPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDEC 518
                +C  CNC G          GPC    +   G+C   + GF     +   GCD+C
Sbjct: 232 ARIAKNCAVCNCGG----------GPC----DSVTGEC--LEEGF-----EPPTGCDKC 269



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 54/208 (25%), Positives = 80/208 (38%), Gaps = 38/208 (18%)

Query: 996  CDRCAHG---YFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHS 1052
            C R A G    F F   G +A          +P+      PP    EKC+      + H+
Sbjct: 21   CSRAASGDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRLPP--AAEKCNA----GFFHT 74

Query: 1053 ITTGCKACNCSTVGSLDFQCNVNTGQC-NCHPKFSGAKCTECSRGHWN-----YPR-CNL 1105
            ++  C  C+C+   +   +C   +G C +C    +G  C +C  G+        P+ C  
Sbjct: 75   LSGECVPCDCNGNSN---ECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQP 131

Query: 1106 CDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPL---- 1161
            C C LP        +  + C   +   +C C  N  G +C+RC PG +G    NPL    
Sbjct: 132  CPCPLPHLA-----NFAESCYRKNGAVRCICNENYAGPNCERCAPGYYG----NPLLIGS 182

Query: 1162 GCSSCYCFGTT------TQCSEAKGLIR 1183
             C  C C G +        C E  G  R
Sbjct: 183  TCKKCDCSGNSDPNLIFEDCDEVTGQCR 210


>gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
          Length = 1816

 Score =  421 bits (1082), Expect = e-117
 Identities = 452/1862 (24%), Positives = 780/1862 (41%), Gaps = 227/1862 (12%)

Query: 1384 LGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHT 1443
            LG    + E C  GF+   S           G CVPC CNG+S+ C   +  C +CQ +T
Sbjct: 57   LGRLPPAAEKCNAGFFHTLS-----------GECVPCDCNGNSNECLDGSGYCVHCQRNT 105

Query: 1444 AGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYE 1502
             G+ CE+C  GY G  ++G P  CQ C CPL   +N F+ SC  +     RC  C   Y 
Sbjct: 106  TGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLAN-FAESCYRKN-GAVRCI-CNENYA 162

Query: 1503 GQYCERCAPGYTGSPGNPGGSCQECEC----DPYGSLPVPCDPVTGFC-TCRPGATGRKC 1557
            G  CERCAPGY G+P   G +C++C+C    DP   +   CD VTG C  C    TG KC
Sbjct: 163  GPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDP-NLIFEDCDEVTGQCRNCLRNTTGFKC 221

Query: 1558 DGCK---HWHAREGWECVFCG------DECTGLLLG-----------------DLARLEQ 1591
            + C    +  AR    C  C       D  TG  L                  D  RL  
Sbjct: 222  ERCAPGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFEPPTGCDKCVWDLTDALRLAA 281

Query: 1592 MVMSINLTGPLP-----APYKMLYGLENMTQELKHLLSPQRAPERL----IQLAEGNLNT 1642
            + +    +G L      A ++ +  +      LK  LS +     L    I  AE  + +
Sbjct: 282  LSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYALRKIQINNAENTMKS 341

Query: 1643 LVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNET 1702
            L++++ EL+ +  + +  G+   +++  T   A  L E   ++    + +N K +   E 
Sbjct: 342  LLSDVEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNKMLYYGEE 401

Query: 1703 LGTRDEAFERNLEGLQKEIDQMIKELR-RKNLETQKEIAEDELVAAEALLKKVKKLFGES 1761
                 +     L   QK    M++E+R R+   TQ+E+ ++E   A  LL + +  +   
Sbjct: 402  HELSPKEISEKLVLAQK----MLEEIRSRQPFFTQRELVDEEADEAYELLSQAES-WQRL 456

Query: 1762 RGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA---NRLFAVNQKNMTALEKKK 1818
              E   +   + E+L DY  K+ D  + L +A + +R+A   NR  A  Q++    EK++
Sbjct: 457  HNETRTLFPVVLEQLDDYNAKLSDLQEALDQALNYVRDAEDMNRATAARQRDH---EKQQ 513

Query: 1819 EAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLS 1878
            E V      +  +L    D L        E++ II     I  ++     EL  K+ +LS
Sbjct: 514  ERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQVKLSNLS 573

Query: 1879 QEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSNIKDYIDEA 1938
                D  + E +  A+    + N+ S  L     +   +   A  A   Y NI +Y+ EA
Sbjct: 574  NLSHDL-VQEAIDHAQDLQQEANELSRKLHS--SDMNGLVQKALDASNVYENIVNYVSEA 630

Query: 1939 EKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDH-LNG 1997
             + A+ A +         +G    +         +S  +LN+A++L    + + D  +  
Sbjct: 631  NETAEFALNTTDRIYDAVSG----IDTQIIYHKDESENLLNQARELQAKAESSSDEAVAD 686

Query: 1998 LKTRIENADARNGDLLRTLNDTLGKLSAIPN-DTAAKLQAVKDKARQANDTAKDVLAQIT 2056
               R+  A AR   L   L+D + +L A    D   +L   +    +AN T  +V     
Sbjct: 687  TSRRVGGALARKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTMEVQQATA 746

Query: 2057 ELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPI 2116
             +  NL    +N      S           + N  +  A   V+NL +   +L+D+L+ +
Sbjct: 747  PMANNLTNWSQNLQHFDSS-----------AYNTAVNSARDAVRNLTEVVPQLLDQLRTV 795

Query: 2117 KELE--DNLKKNISEIKELINQARKQANSIKVSVSSGGDCI-----RTYKPEIKKGSYNN 2169
            ++     N+  +I  I+ELI Q R  A+ I+VS+   G        RT   ++K  ++ +
Sbjct: 796  EQKRPASNVSASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDLK--AFTS 853

Query: 2170 IVVNVK--------TAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYP 2220
            + + +K        T  AD  + YLGS     +++ + ++   + +++++G+    +   
Sbjct: 854  LSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIPLD 913

Query: 2221 DLTIDD--SYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDA-NA 2277
               +    +Y+  +   R G++G + +        +              ++LD+D  + 
Sbjct: 914  SKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDT 973

Query: 2278 MLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDS 2337
            + +VGG+    K   ++ +  F GC+     +N  I L+NF+         +V P   D 
Sbjct: 974  VFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYNFKHIYNMDPSTSV-PCARDK 1032

Query: 2338 EGTIQ-------FDGEGYALVSRPIRW--YPNISTVMFKFRTFSSSALLMYLATRDLRDF 2388
                Q       FDG GYA+V    R   +  ++    + RT + + L++ +    +  F
Sbjct: 1033 LAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSM--F 1090

Query: 2389 MSVELTDGHIKVSYDLG-SG----MASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDT 2443
              +E+ +G++ V YD G SG    +   +     ND K+   ++     +  I +VD   
Sbjct: 1091 FRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVD--- 1147

Query: 2444 NQEENIATSSSGNNFGLDLKADDKIYFGGLPT--LRNLSMKARPEVNLKKYSGCLKDIEI 2501
                ++    S +N  + +   D IY GG P   L++ +++A   +++  + GC+K  + 
Sbjct: 1148 --RRHV---KSMDNEKMKIPFTD-IYIGGAPPEILQSRALRAHLPLDIN-FRGCMKGFQF 1200

Query: 2502 SRTPYNILSSPDYVGVTKGCSLENVYT--VSFPKPGFV-ELSPVPIDVGTEINLSFSTKN 2558
             +  +N+L   + +GV  GC  +++ +    F    F+  +  +    G E   +F T  
Sbjct: 1201 QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQ 1260

Query: 2559 ESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLF 2618
             +G++   + G+               + I L+ G       T    ++ I ++     +
Sbjct: 1261 PNGLLFYYASGSDV-------------FSISLDNG-------TVIMDVKGIKVQSVDKQY 1300

Query: 2619 HDGREHSVHVERTRGIFTVQVDENRRYMQNLT---VEQP-IEVKKLFVGGAPPEFQPSPL 2674
            +DG  H V    +   + + VD++R   +N T   +EQ     KK + GG+P   Q +  
Sbjct: 1301 NDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYAN- 1359

Query: 2675 RNIPPFEGCIWNLVINSVPMD-----FARPVSFKNADIGRC------------------- 2710
                 F GCI N     V  D     F R     +  +  C                   
Sbjct: 1360 -----FTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSK 1414

Query: 2711 --AHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGL 2768
              A Q  +  +   AP+      +PV        TP  +H  C   + P  +  + Q+G 
Sbjct: 1415 PKASQNKKGGKSKDAPSW-----DPVALKLPERNTPRNSH--CHLSNSPRAIEHAYQYGG 1467

Query: 2769 SRNSHIAIAF--DDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFS 2826
            + NS         D   K++ +I L  RT +  G++FY++     DF T+ L +G   + 
Sbjct: 1468 TANSRQEFEHLKGDFGAKSQFSIRL--RTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYM 1525

Query: 2827 YDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGM 2884
            +++G          K NDG WH +  +R +  G L +DG      ++ P +A    + G 
Sbjct: 1526 FNVGHKKLKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEA-TWKIKGP 1584

Query: 2885 LYVGGLPINYTTRRIG-PVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-AQRGT 2942
            +Y+GG+      + +     YS  GC+ NL +    A +   + +F V  CF    + GT
Sbjct: 1585 IYLGGVAPGKAVKNVQINSIYSFSGCLSNLQL--NGASITSASQTFSVTPCFEGPMETGT 1642

Query: 2943 YFDGT-GFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHV 3001
            YF    G+      F +GL   + FE R  +++G L+   S   + + + M + +++  V
Sbjct: 1643 YFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKV 1702

Query: 3002 DNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSP-NPASTSADT 3060
            +NG   F+          LCDG+WH++T  +  + ++L VD        P NP     D 
Sbjct: 1703 NNGIRDFST--SVTPKQSLCDGRWHRITVIRDSNVVQLDVDSEVNHVVGPLNP--KPIDH 1758

Query: 3061 NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPV-SC 3119
             +PVFVGG P+ L    L  S PF GCIR   +    G P  V+F+KA  + G   + SC
Sbjct: 1759 REPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI---DGHP--VSFSKAALVSGAVSINSC 1813

Query: 3120 PA 3121
            PA
Sbjct: 1814 PA 1815



 Score =  175 bits (444), Expect = 6e-43
 Identities = 88/216 (40%), Positives = 117/216 (54%), Gaps = 12/216 (5%)

Query: 740 PRHRRVNGTIF---GGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEP 796
           P   + N   F    G C PC C G++  C D +G C++C+ +T G +C+KCL G+ G+ 
Sbjct: 62  PAAEKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 797 TKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPS 856
            +G  + CQPC CPL   + NF+ +C+  R  G +   C   Y GP CERCA GY+G P 
Sbjct: 122 IRGAPQFCQPCPCPLPHLA-NFAESCY--RKNGAVRCICNENYAGPNCERCAPGYYGNPL 178

Query: 857 VPGGSCQPCQCNDNLDFS-IPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNC 915
           + G +C+ C C+ N D + I   CD ++G C  C   TTG  CE CA GY+GDA  AKNC
Sbjct: 179 LIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNC 238

Query: 916 QPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKC 951
             C C  G      C S TG+C          CDKC
Sbjct: 239 AVCNCGGG-----PCDSVTGECLEEGFEPPTGCDKC 269



 Score =  132 bits (332), Expect = 5e-30
 Identities = 79/223 (35%), Positives = 106/223 (47%), Gaps = 25/223 (11%)

Query: 837  VGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGR 896
            +G   P  E+C  G+F   S   G C PC CN N +  + GS     G C+ C+  TTG 
Sbjct: 57   LGRLPPAAEKCNAGFFHTLS---GECVPCDCNGNSNECLDGS-----GYCVHCQRNTTGE 108

Query: 897  YCELCADGYFGDAVDA--KNCQPCRCNAG--GSFSEVCHSQTG--QCECRANVQGQRCDK 950
            +CE C DGY GD++    + CQPC C      +F+E C+ + G  +C C  N  G  C++
Sbjct: 109  HCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCER 168

Query: 951  CKAGTFG--LQSARGCVPCNCNSFGSKSF---DCEE-SGQCW-CQPGVTGKKCDRCAHGY 1003
            C  G +G  L     C  C+C+     +    DC+E +GQC  C    TG KC+RCA GY
Sbjct: 169  CAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGY 228

Query: 1004 FNFQE--GGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKC 1044
            +        C  C C   G  CD  TG C+         C KC
Sbjct: 229  YGDARIAKNCAVCNCG--GGPCDSVTGECLEEGFEPPTGCDKC 269



 Score =  110 bits (275), Expect = 2e-23
 Identities = 74/199 (37%), Positives = 98/199 (49%), Gaps = 30/199 (15%)

Query: 949  DKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQC-WCQPGVTGKKCDRCAHGYFNFQ 1007
            +KC AG F   S   CVPC+CN   ++  D   SG C  CQ   TG+ C++C  GY    
Sbjct: 65   EKCNAGFFHTLSGE-CVPCDCNGNSNECLD--GSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 1008 EGG----CTACECS--HLGN---NCDPKTG--RCICPPNTIGEKCSKCAPNTWGHSITTG 1056
              G    C  C C   HL N   +C  K G  RCIC  N  G  C +CAP  +G+ +  G
Sbjct: 122  IRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIG 181

Query: 1057 --CKACNCS--TVGSLDFQ-CNVNTGQC-NCHPKFSGAKCTECSRGHWNYPR----CNLC 1106
              CK C+CS  +  +L F+ C+  TGQC NC    +G KC  C+ G++   R    C +C
Sbjct: 182  STCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVC 241

Query: 1107 DCFLPGTDATTCDSETKKC 1125
            +C         CDS T +C
Sbjct: 242  NC-----GGGPCDSVTGEC 255



 Score =  102 bits (254), Expect = 6e-21
 Identities = 63/200 (31%), Positives = 87/200 (43%), Gaps = 26/200 (13%)

Query: 997  DRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCI-CPPNTIGEKCSKCAPNTWGHSITT 1055
            ++C  G+F+   G C  C+C+   N C   +G C+ C  NT GE C KC     G SI  
Sbjct: 65   EKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRG 124

Query: 1056 G---CKACNCSTVGSLDF--QCNVNTG--QCNCHPKFSGAKCTECSRGHWNYP-----RC 1103
                C+ C C      +F   C    G  +C C+  ++G  C  C+ G++  P      C
Sbjct: 125  APQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTC 184

Query: 1104 NLCDCFLPGTDATTCDSETKKCSCSDQTGQC-TCKVNVEGIHCDRCRPGKFGLDAKNPLG 1162
              CDC      +   D       C + TGQC  C  N  G  C+RC PG +G DA+    
Sbjct: 185  KKCDC------SGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYG-DARIAKN 237

Query: 1163 CSSCYCFG-----TTTQCSE 1177
            C+ C C G      T +C E
Sbjct: 238  CAVCNCGGGPCDSVTGECLE 257



 Score = 99.8 bits (247), Expect = 4e-20
 Identities = 76/261 (29%), Positives = 105/261 (40%), Gaps = 48/261 (18%)

Query: 332 AGTFLTKT-ECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINC 390
           AG F T + EC  C+C+G + EC                    G G C++C +NT G +C
Sbjct: 69  AGFFHTLSGECVPCDCNGNSNECLD------------------GSGYCVHCQRNTTGEHC 110

Query: 391 ETCTDGFFRPK-GVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449
           E C DG+       +P + +PC PC    + +  E C +     R       C C   + 
Sbjct: 111 EKCLDGYIGDSIRGAPQFCQPC-PCPLPHLANFAESCYRKNGAVR-------CICNENYA 162

Query: 450 GVSCDRCARGYTGYP-----DCKACNCSGLGSKNE-----DPCFGPC-ICKENVEGGDCS 498
           G +C+RCA GY G P      CK C+CSG    N      D   G C  C  N  G  C 
Sbjct: 163 GPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCE 222

Query: 499 RCKSGFFNLQEDNWKGCDECFCSG-----VSNRCQSSYWTYGKIQDMSGWYLTDLPGRIR 553
           RC  G++       K C  C C G     V+  C    +      D   W LTD    +R
Sbjct: 223 RCAPGYYG-DARIAKNCAVCNCGGGPCDSVTGECLEEGFEPPTGCDKCVWDLTD---ALR 278

Query: 554 VAPQQDDLDSPQQISISNAEA 574
           +A    +      +S+S+  A
Sbjct: 279 LAALSIEEGKSGVLSVSSGAA 299



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 34/92 (36%), Positives = 50/92 (54%), Gaps = 9/92 (9%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHA------ESCDDVTGECLNCK 777
           C C   Y G +CE C P +   N  + G  C+ C C G++      E CD+VTG+C NC 
Sbjct: 155 CICNENYAGPNCERCAPGYYG-NPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCL 213

Query: 778 DHTGGPYCDKCLPGFYGEPTKGTSEDCQPCAC 809
            +T G  C++C PG+YG+     +++C  C C
Sbjct: 214 RNTTGFKCERCAPGYYGDAR--IAKNCAVCNC 243



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 67/239 (28%), Positives = 91/239 (38%), Gaps = 58/239 (24%)

Query: 287 CICYGHARACPLDPATNKSRC-ECEHNTCGDSCDQCCPGFHQKPWR-AGTFLTKTECEAC 344
           C C G++  C LD       C  C+ NT G+ C++C  G+     R A  F     C   
Sbjct: 82  CDCNGNSNEC-LD---GSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLP 137

Query: 345 NCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVS 404
           +    AE CY      R+N           G V   C +N AG NCE C  G++   G  
Sbjct: 138 HLANFAESCY------RKN-----------GAVRCICNENYAGPNCERCAPGYY---GNP 177

Query: 405 PNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC-HCKTGFGGVSCDRCARGYTG- 462
                 C+ C C      N +    ++        G C +C     G  C+RCA GY G 
Sbjct: 178 LLIGSTCKKCDCSGNSDPNLIFEDCDE------VTGQCRNCLRNTTGFKCERCAPGYYGD 231

Query: 463 ---YPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDEC 518
                +C  CNC G          GPC    +   G+C   + GF     +   GCD+C
Sbjct: 232 ARIAKNCAVCNCGG----------GPC----DSVTGEC--LEEGF-----EPPTGCDKC 269



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 54/208 (25%), Positives = 80/208 (38%), Gaps = 38/208 (18%)

Query: 996  CDRCAHG---YFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHS 1052
            C R A G    F F   G +A          +P+      PP    EKC+      + H+
Sbjct: 21   CSRAASGDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRLPP--AAEKCNA----GFFHT 74

Query: 1053 ITTGCKACNCSTVGSLDFQCNVNTGQC-NCHPKFSGAKCTECSRGHWN-----YPR-CNL 1105
            ++  C  C+C+   +   +C   +G C +C    +G  C +C  G+        P+ C  
Sbjct: 75   LSGECVPCDCNGNSN---ECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQP 131

Query: 1106 CDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPL---- 1161
            C C LP        +  + C   +   +C C  N  G +C+RC PG +G    NPL    
Sbjct: 132  CPCPLPHLA-----NFAESCYRKNGAVRCICNENYAGPNCERCAPGYYG----NPLLIGS 182

Query: 1162 GCSSCYCFGTT------TQCSEAKGLIR 1183
             C  C C G +        C E  G  R
Sbjct: 183  TCKKCDCSGNSDPNLIFEDCDEVTGQCR 210


>gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]
          Length = 1823

 Score =  418 bits (1075), Expect = e-116
 Identities = 452/1869 (24%), Positives = 780/1869 (41%), Gaps = 234/1869 (12%)

Query: 1384 LGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHT 1443
            LG    + E C  GF+   S           G CVPC CNG+S+ C   +  C +CQ +T
Sbjct: 57   LGRLPPAAEKCNAGFFHTLS-----------GECVPCDCNGNSNECLDGSGYCVHCQRNT 105

Query: 1444 AGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYE 1502
             G+ CE+C  GY G  ++G P  CQ C CPL   +N F+ SC  +     RC  C   Y 
Sbjct: 106  TGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLAN-FAESCYRKN-GAVRCI-CNENYA 162

Query: 1503 GQYCERCAPGYTGSPGNPGGSCQECEC----DPYGSLPVPCDPVTGFC-TCRPGATGRKC 1557
            G  CERCAPGY G+P   G +C++C+C    DP   +   CD VTG C  C    TG KC
Sbjct: 163  GPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDP-NLIFEDCDEVTGQCRNCLRNTTGFKC 221

Query: 1558 DGCK---HWHAREGWECVFCG------DECTGLLLG------------------------ 1584
            + C    +  AR    C  C       D  TG  L                         
Sbjct: 222  ERCAPGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFEPPTGMDCPTISCDKCVWDLT 281

Query: 1585 DLARLEQMVMSINLTGPLP-----APYKMLYGLENMTQELKHLLSPQRAPERL----IQL 1635
            D  RL  + +    +G L      A ++ +  +      LK  LS +     L    I  
Sbjct: 282  DALRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYALRKIQINN 341

Query: 1636 AEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEK 1695
            AE  + +L++++ EL+ +  + +  G+   +++  T   A  L E   ++    + +N K
Sbjct: 342  AENTMKSLLSDVEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDMRDKIQEINNK 401

Query: 1696 AIKLNETLGTRDEAFERNLEGLQKEIDQMIKELR-RKNLETQKEIAEDELVAAEALLKKV 1754
             +   E      +     L   QK    M++E+R R+   TQ+E+ ++E   A  LL + 
Sbjct: 402  MLYYGEEHELSPKEISEKLVLAQK----MLEEIRSRQPFFTQRELVDEEADEAYELLSQA 457

Query: 1755 KKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA---NRLFAVNQKNM 1811
            +  +     E   +   + E+L DY  K+ D  + L +A + +R+A   NR  A  Q++ 
Sbjct: 458  ES-WQRLHNETRTLFPVVLEQLDDYNAKLSDLQEALDQALNYVRDAEDMNRATAARQRDH 516

Query: 1812 TALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELN 1871
               EK++E V      +  +L    D L        E++ II     I  ++     EL 
Sbjct: 517  ---EKQQERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQ 573

Query: 1872 DKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSNI 1931
             K+ +LS    D  + E +  A+    + N+ S  L     +   +   A  A   Y NI
Sbjct: 574  VKLSNLSNLSHDL-VQEAIDHAQDLQQEANELSRKLHS--SDMNGLVQKALDASNVYENI 630

Query: 1932 KDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKEN 1991
             +Y+ EA + A+ A +         +G    +         +S  +LN+A++L    + +
Sbjct: 631  VNYVSEANETAEFALNTTDRIYDAVSG----IDTQIIYHKDESENLLNQARELQAKAESS 686

Query: 1992 EDH-LNGLKTRIENADARNGDLLRTLNDTLGKLSAIPN-DTAAKLQAVKDKARQANDTAK 2049
             D  +     R+  A AR   L   L+D + +L A    D   +L   +    +AN T  
Sbjct: 687  SDEAVADTSRRVGGALARKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTM 746

Query: 2050 DVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRL 2109
            +V      +  NL    +N      S           + N  +  A   V+NL +   +L
Sbjct: 747  EVQQATAPMANNLTNWSQNLQHFDSS-----------AYNTAVNSARDAVRNLTEVVPQL 795

Query: 2110 IDKLKPIKELE--DNLKKNISEIKELINQARKQANSIKVSVSSGGDCI-----RTYKPEI 2162
            +D+L+ +++     N+  +I  I+ELI Q R  A+ I+VS+   G        RT   ++
Sbjct: 796  LDQLRTVEQKRPASNVSASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDL 855

Query: 2163 KKGSYNNIVVNVK--------TAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSG 2213
            K  ++ ++ + +K        T  AD  + YLGS     +++ + ++   + +++++G+ 
Sbjct: 856  K--AFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTK 913

Query: 2214 VGRVEYPDLTIDD--SYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTIL 2271
               +      +    +Y+  +   R G++G + +        +              ++L
Sbjct: 914  DVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLL 973

Query: 2272 DVDA-NAMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTV 2330
            D+D  + + +VGG+    K   ++ +  F GC+     +N  I L+NF+         +V
Sbjct: 974  DLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYNFKHIYNMDPSTSV 1033

Query: 2331 SPQVEDSEGTIQ-------FDGEGYALVSRPIRW--YPNISTVMFKFRTFSSSALLMYLA 2381
             P   D     Q       FDG GYA+V    R   +  ++    + RT + + L++ + 
Sbjct: 1034 -PCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMV 1092

Query: 2382 TRDLRDFMSVELTDGHIKVSYDLG-SG----MASVVSNQNHNDGKWKSFTLSRIQKQANI 2436
               +  F  +E+ +G++ V YD G SG    +   +     ND K+   ++     +  I
Sbjct: 1093 NGSM--FFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMI 1150

Query: 2437 SIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPT--LRNLSMKARPEVNLKKYSG 2494
             +VD       ++    S +N  + +   D IY GG P   L++ +++A   +++  + G
Sbjct: 1151 LVVD-----RRHV---KSMDNEKMKIPFTD-IYIGGAPPEILQSRALRAHLPLDIN-FRG 1200

Query: 2495 CLKDIEISRTPYNILSSPDYVGVTKGCSLENVYT--VSFPKPGFV-ELSPVPIDVGTEIN 2551
            C+K  +  +  +N+L   + +GV  GC  +++ +    F    F+  +  +    G E  
Sbjct: 1201 CMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGG 1260

Query: 2552 LSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGARTMRKIVI 2611
             +F T   +G++   + G+               + I L+ G       T    ++ I +
Sbjct: 1261 FNFRTLQPNGLLFYYASGSDV-------------FSISLDNG-------TVIMDVKGIKV 1300

Query: 2612 RPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLT---VEQP-IEVKKLFVGGAPP 2667
            +     ++DG  H V    +   + + VD++R   +N T   +EQ     KK + GG+P 
Sbjct: 1301 QSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPI 1360

Query: 2668 EFQPSPLRNIPPFEGCIWNLVINSVPMD-----FARPVSFKNADIGRC------------ 2710
              Q +       F GCI N     V  D     F R     +  +  C            
Sbjct: 1361 SAQYAN------FTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHK 1414

Query: 2711 ---------AHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLI 2761
                     A Q  +  +   AP+      +PV        TP  +H  C   + P  + 
Sbjct: 1415 KGKNLSKPKASQNKKGGKSKDAPSW-----DPVALKLPERNTPRNSH--CHLSNSPRAIE 1467

Query: 2762 GSKQFGLSRNSHIAIAF--DDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLR 2819
             + Q+G + NS         D   K++ +I L  RT +  G++FY++     DF T+ L 
Sbjct: 1468 HAYQYGGTANSRQEFEHLKGDFGAKSQFSIRL--RTRSSHGMIFYVSDQEENDFMTLFLA 1525

Query: 2820 NGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKAD 2877
            +G   + +++G          K NDG WH +  +R +  G L +DG      ++ P +A 
Sbjct: 1526 HGRLVYMFNVGHKKLKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEA- 1584

Query: 2878 ILDVVGMLYVGGLPINYTTRRIG-PVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFA 2936
               + G +Y+GG+      + +     YS  GC+ NL +    A +   + +F V  CF 
Sbjct: 1585 TWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQL--NGASITSASQTFSVTPCFE 1642

Query: 2937 N-AQRGTYFDGT-GFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMID 2994
               + GTYF    G+      F +GL   + FE R  +++G L+   S   + + + M +
Sbjct: 1643 GPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKN 1702

Query: 2995 EKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSP-NP 3053
             +++  V+NG   F+          LCDG+WH++T  +  + ++L VD        P NP
Sbjct: 1703 GQVIVKVNNGIRDFST--SVTPKQSLCDGRWHRITVIRDSNVVQLDVDSEVNHVVGPLNP 1760

Query: 3054 ASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRG 3113
                 D  +PVFVGG P+ L    L  S PF GCIR   +    G P  V+F+KA  + G
Sbjct: 1761 --KPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI---DGHP--VSFSKAALVSG 1813

Query: 3114 VQPV-SCPA 3121
               + SCPA
Sbjct: 1814 AVSINSCPA 1822



 Score =  171 bits (433), Expect = 1e-41
 Identities = 84/202 (41%), Positives = 113/202 (55%), Gaps = 12/202 (5%)

Query: 740 PRHRRVNGTIF---GGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEP 796
           P   + N   F    G C PC C G++  C D +G C++C+ +T G +C+KCL G+ G+ 
Sbjct: 62  PAAEKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 797 TKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPS 856
            +G  + CQPC CPL   + NF+ +C+  R  G +   C   Y GP CERCA GY+G P 
Sbjct: 122 IRGAPQFCQPCPCPLPHLA-NFAESCY--RKNGAVRCICNENYAGPNCERCAPGYYGNPL 178

Query: 857 VPGGSCQPCQCNDNLDFS-IPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNC 915
           + G +C+ C C+ N D + I   CD ++G C  C   TTG  CE CA GY+GDA  AKNC
Sbjct: 179 LIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNC 238

Query: 916 QPCRCNAGGSFSEVCHSQTGQC 937
             C C  G      C S TG+C
Sbjct: 239 AVCNCGGG-----PCDSVTGEC 255



 Score =  130 bits (328), Expect = 2e-29
 Identities = 76/210 (36%), Positives = 103/210 (49%), Gaps = 25/210 (11%)

Query: 837  VGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGR 896
            +G   P  E+C  G+F   S   G C PC CN N +  + GS     G C+ C+  TTG 
Sbjct: 57   LGRLPPAAEKCNAGFFHTLS---GECVPCDCNGNSNECLDGS-----GYCVHCQRNTTGE 108

Query: 897  YCELCADGYFGDAVDA--KNCQPCRCNAG--GSFSEVCHSQTG--QCECRANVQGQRCDK 950
            +CE C DGY GD++    + CQPC C      +F+E C+ + G  +C C  N  G  C++
Sbjct: 109  HCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCER 168

Query: 951  CKAGTFG--LQSARGCVPCNCNSFGSKSF---DCEE-SGQCW-CQPGVTGKKCDRCAHGY 1003
            C  G +G  L     C  C+C+     +    DC+E +GQC  C    TG KC+RCA GY
Sbjct: 169  CAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGY 228

Query: 1004 FNFQE--GGCTACECSHLGNNCDPKTGRCI 1031
            +        C  C C   G  CD  TG C+
Sbjct: 229  YGDARIAKNCAVCNCG--GGPCDSVTGECL 256



 Score =  112 bits (281), Expect = 4e-24
 Identities = 78/222 (35%), Positives = 108/222 (48%), Gaps = 32/222 (14%)

Query: 949  DKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQC-WCQPGVTGKKCDRCAHGYFNFQ 1007
            +KC AG F   S   CVPC+CN   ++  D   SG C  CQ   TG+ C++C  GY    
Sbjct: 65   EKCNAGFFHTLSGE-CVPCDCNGNSNECLD--GSGYCVHCQRNTTGEHCEKCLDGYIGDS 121

Query: 1008 EGG----CTACECS--HLGN---NCDPKTG--RCICPPNTIGEKCSKCAPNTWGHSITTG 1056
              G    C  C C   HL N   +C  K G  RCIC  N  G  C +CAP  +G+ +  G
Sbjct: 122  IRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIG 181

Query: 1057 --CKACNCS--TVGSLDFQ-CNVNTGQC-NCHPKFSGAKCTECSRGHWNYPR----CNLC 1106
              CK C+CS  +  +L F+ C+  TGQC NC    +G KC  C+ G++   R    C +C
Sbjct: 182  STCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVC 241

Query: 1107 DCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRC 1148
            +C         CDS T +  C ++  +    ++   I CD+C
Sbjct: 242  NC-----GGGPCDSVTGE--CLEEGFEPPTGMDCPTISCDKC 276



 Score =  102 bits (254), Expect = 6e-21
 Identities = 63/200 (31%), Positives = 87/200 (43%), Gaps = 26/200 (13%)

Query: 997  DRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCI-CPPNTIGEKCSKCAPNTWGHSITT 1055
            ++C  G+F+   G C  C+C+   N C   +G C+ C  NT GE C KC     G SI  
Sbjct: 65   EKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRG 124

Query: 1056 G---CKACNCSTVGSLDF--QCNVNTG--QCNCHPKFSGAKCTECSRGHWNYP-----RC 1103
                C+ C C      +F   C    G  +C C+  ++G  C  C+ G++  P      C
Sbjct: 125  APQFCQPCPCPLPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLIGSTC 184

Query: 1104 NLCDCFLPGTDATTCDSETKKCSCSDQTGQC-TCKVNVEGIHCDRCRPGKFGLDAKNPLG 1162
              CDC      +   D       C + TGQC  C  N  G  C+RC PG +G DA+    
Sbjct: 185  KKCDC------SGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYG-DARIAKN 237

Query: 1163 CSSCYCFG-----TTTQCSE 1177
            C+ C C G      T +C E
Sbjct: 238  CAVCNCGGGPCDSVTGECLE 257



 Score = 97.8 bits (242), Expect = 1e-19
 Identities = 64/204 (31%), Positives = 85/204 (41%), Gaps = 40/204 (19%)

Query: 332 AGTFLTKT-ECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINC 390
           AG F T + EC  C+C+G + EC                    G G C++C +NT G +C
Sbjct: 69  AGFFHTLSGECVPCDCNGNSNECLD------------------GSGYCVHCQRNTTGEHC 110

Query: 391 ETCTDGFFRPK-GVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449
           E C DG+       +P + +PC PC    + +  E C +     R       C C   + 
Sbjct: 111 EKCLDGYIGDSIRGAPQFCQPC-PCPLPHLANFAESCYRKNGAVR-------CICNENYA 162

Query: 450 GVSCDRCARGYTGYP-----DCKACNCSGLGSKNE-----DPCFGPC-ICKENVEGGDCS 498
           G +C+RCA GY G P      CK C+CSG    N      D   G C  C  N  G  C 
Sbjct: 163 GPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTGFKCE 222

Query: 499 RCKSGFFNLQEDNWKGCDECFCSG 522
           RC  G++       K C  C C G
Sbjct: 223 RCAPGYYG-DARIAKNCAVCNCGG 245



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 34/92 (36%), Positives = 50/92 (54%), Gaps = 9/92 (9%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHA------ESCDDVTGECLNCK 777
           C C   Y G +CE C P +   N  + G  C+ C C G++      E CD+VTG+C NC 
Sbjct: 155 CICNENYAGPNCERCAPGYYG-NPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCL 213

Query: 778 DHTGGPYCDKCLPGFYGEPTKGTSEDCQPCAC 809
            +T G  C++C PG+YG+     +++C  C C
Sbjct: 214 RNTTGFKCERCAPGYYGDAR--IAKNCAVCNC 243



 Score = 69.7 bits (169), Expect = 4e-11
 Identities = 41/153 (26%), Positives = 65/153 (42%), Gaps = 32/153 (20%)

Query: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
           RC C  N  G +C++C PG++  P      L  + C+ C+C G ++     E+       
Sbjct: 154 RCICNENYAGPNCERCAPGYYGNP-----LLIGSTCKKCDCSGNSDPNLIFEDCDEVT-- 206

Query: 366 LNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHC--DPIGSLN 423
                     G C NC +NT G  CE C  G++    ++ N    C  C+C   P  S+ 
Sbjct: 207 ----------GQCRNCLRNTTGFKCERCAPGYYGDARIAKN----CAVCNCGGGPCDSVT 252

Query: 424 EVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRC 456
             C+++      G+      C T    +SCD+C
Sbjct: 253 GECLEEGFEPPTGM-----DCPT----ISCDKC 276



 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 59/207 (28%), Positives = 78/207 (37%), Gaps = 47/207 (22%)

Query: 287 CICYGHARACPLDPATNKSRC-ECEHNTCGDSCDQCCPGFHQKPWR-AGTFLTKTECEAC 344
           C C G++  C LD       C  C+ NT G+ C++C  G+     R A  F     C   
Sbjct: 82  CDCNGNSNEC-LD---GSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLP 137

Query: 345 NCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVS 404
           +    AE CY      R+N           G V   C +N AG NCE C  G++   G  
Sbjct: 138 HLANFAESCY------RKN-----------GAVRCICNENYAGPNCERCAPGYY---GNP 177

Query: 405 PNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC-HCKTGFGGVSCDRCARGYTG- 462
                 C+ C C      N +    ++        G C +C     G  C+RCA GY G 
Sbjct: 178 LLIGSTCKKCDCSGNSDPNLIFEDCDE------VTGQCRNCLRNTTGFKCERCAPGYYGD 231

Query: 463 ---YPDCKACNCSGLGSKNEDPCFGPC 486
                +C  CNC G          GPC
Sbjct: 232 ARIAKNCAVCNCGG----------GPC 248



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 54/208 (25%), Positives = 80/208 (38%), Gaps = 38/208 (18%)

Query: 996  CDRCAHG---YFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHS 1052
            C R A G    F F   G +A          +P+      PP    EKC+      + H+
Sbjct: 21   CSRAASGDDNAFPFDIEGSSAVGRQDPPETSEPRVALGRLPP--AAEKCNA----GFFHT 74

Query: 1053 ITTGCKACNCSTVGSLDFQCNVNTGQC-NCHPKFSGAKCTECSRGHWN-----YPR-CNL 1105
            ++  C  C+C+   +   +C   +G C +C    +G  C +C  G+        P+ C  
Sbjct: 75   LSGECVPCDCNGNSN---ECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQP 131

Query: 1106 CDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPL---- 1161
            C C LP        +  + C   +   +C C  N  G +C+RC PG +G    NPL    
Sbjct: 132  CPCPLPHLA-----NFAESCYRKNGAVRCICNENYAGPNCERCAPGYYG----NPLLIGS 182

Query: 1162 GCSSCYCFGTT------TQCSEAKGLIR 1183
             C  C C G +        C E  G  R
Sbjct: 183  TCKKCDCSGNSDPNLIFEDCDEVTGQCR 210



 Score = 33.9 bits (76), Expect = 2.6
 Identities = 25/70 (35%), Positives = 28/70 (40%), Gaps = 10/70 (14%)

Query: 726 CPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECL--NCKDHTGGP 783
           C    TG  CE C P +           C  C C G    CD VTGECL    +  TG  
Sbjct: 212 CLRNTTGFKCERCAPGY--YGDARIAKNCAVCNCGGGP--CDSVTGECLEEGFEPPTGMD 267

Query: 784 ----YCDKCL 789
                CDKC+
Sbjct: 268 CPTISCDKCV 277


>gi|189217428 laminin alpha 3 subunit isoform 4 [Homo sapiens]
          Length = 1668

 Score =  410 bits (1053), Expect = e-113
 Identities = 448/1801 (24%), Positives = 742/1801 (41%), Gaps = 263/1801 (14%)

Query: 1392 EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAGDFCERC 1451
            + C PG+YR          G   G CVPC CNGHS+ C   + IC NCQH+TAG+ CERC
Sbjct: 57   QGCSPGYYRDHK-------GLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERC 109

Query: 1452 ALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAP 1511
              GYYG    +   C+ C CP    +N+F+  CV  G  D RC+ C  GY G  CERCAP
Sbjct: 110  QEGYYG--NAVHGSCRACPCP---HTNSFATGCVVNG-GDVRCS-CKAGYTGTQCERCAP 162

Query: 1512 GYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTC---RPGATGRKCDGCKHWHAREG 1568
            GY G+P   GGSCQ C C+  G L   C P+TG C     +  +   +CD C        
Sbjct: 163  GYFGNPQKFGGSCQPCSCNSNGQLG-SCHPLTGDCINQEPKDSSPAEECDDC-------- 213

Query: 1569 WECVFCGDECTGLLLGDLARL-EQMVMSINLTGPLPAPYKMLYGLENMTQELKHLLSPQR 1627
                   D C   LL DLA + EQ+ +  +    L A   +L  + +M  + K L     
Sbjct: 214  -------DSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDL----- 261

Query: 1628 APERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQT-GQDAERTNTRAKSLGEFIKELA 1686
                                N+LL   + ++  G +  G + E T+     L +  + L 
Sbjct: 262  -------------------RNQLLNYRSAISNHGSKIEGLERELTD-----LNQEFETLQ 297

Query: 1687 RDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVA 1746
              A+  + KA  LN  +    ++         KE+D  IK + R                
Sbjct: 298  EKAQVNSRKAQTLNNNVNRATQS--------AKELDVKIKNVIRN--------------- 334

Query: 1747 AEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAV 1806
               +L +++      +GEN  +   +R+ L +Y+ K+ D    L+EA  + ++AN L   
Sbjct: 335  -VHMLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQE 393

Query: 1807 NQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPM 1866
            N++ + A++++ + + S +      L   +  L + N     +       E +   L   
Sbjct: 394  NERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEA 453

Query: 1867 SEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATA--A 1924
             +EL+DK+ +LS+      L E   +AE HA  L + +  L+ I   A        A  A
Sbjct: 454  RQELSDKVRELSRSAGKTSLVE---EAEKHARSLQELAKQLEEIKRNASGDELVRCAVDA 510

Query: 1925 FKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKL 1984
              AY NI + I  AE  A  A   +  A  L T  +  L   AK     S ++LNEAK  
Sbjct: 511  ATAYENILNAIKAAEDAANRAASASESA--LQTVIKEDLPRKAKTLSSNSDKLLNEAKMT 568

Query: 1985 ANDVKEN-EDHLNGLKTRIENADARNGDL---LRTLNDTLGKLSAIPNDTAAKLQAVKDK 2040
               +K+     LN L+  +     +   +   L TL D L  +     D  A + + K  
Sbjct: 569  QKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQR--GDIDAMISSAKSM 626

Query: 2041 ARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK 2100
             R+AND   +VL  +  +  +++ +K  Y +  +   K           K + DAD +V 
Sbjct: 627  VRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFK-----------KALTDADNSVN 675

Query: 2101 NLEQEADRLIDKLKPIKELE---DNLKKNISEIKELINQARKQANSIKVSVSSGGDC-IR 2156
             L  +   L  K++ I +      N+  N+  I+ELI QAR  A+ + V +   G   + 
Sbjct: 676  KLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVE 735

Query: 2157 TYKP---EIKKGSYNNIVVNVKT-------AVADNLLFYLGSAKFI-DFLAIEMRKGKVS 2205
               P   E  KG Y ++ + ++           +  + YLG+     D++ + +  G+++
Sbjct: 736  VRLPNDLEDLKG-YTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDGQLT 794

Query: 2206 FLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASI-----VPSTH 2260
             ++++G     ++  D  +  S     V  R           L+  K +       P  +
Sbjct: 795  CVYNLGDREAELQV-DQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVY 853

Query: 2261 HSTSPPGYTILDVDA-NAMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFR 2319
                    T+L++D  N + +VGG     K    +    + GC+     +   + L+NF+
Sbjct: 854  DMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFK 913

Query: 2320 EKEGDCKGCTVSP---QVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSAL 2376
             K  +     V P   + E+S+    F+G GYA V  P + +  I T     +T     L
Sbjct: 914  -KTFNLNTTEVEPCRRRKEESDKNY-FEGTGYARV--PTQPHAPIPTFGQTIQTTVDRGL 969

Query: 2377 LMYLATRDLRDFMSVELTDGHIKVSYDLGS------GMASVVSNQNHNDGKWKSFTLSRI 2430
            L +    D   F+S+ + DG + V Y L S      G+   ++N   +  + K   + ++
Sbjct: 970  LFFAENGDR--FISLNIEDGKLMVRYKLNSELPKERGVGDAINNGRDHSIQIK---IGKL 1024

Query: 2431 QKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLK 2490
            QK+  I+ VD+         T   G  F          Y GG+P    ++++ R  ++  
Sbjct: 1025 QKRMWIN-VDVQN-------TIIDGEVFDFST-----YYLGGIP----IAIRERFNISTP 1067

Query: 2491 KYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLE--NVYTVSFPKPG---FVELSPVPID 2545
             + GC+K+++ +     ++   D VGVTK CS +   V + SF + G   F +L   P D
Sbjct: 1068 AFRGCMKNLKKTS---GVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPPTD 1124

Query: 2546 VGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGART 2605
               + +  F T   SGI+L               QT      + L  G +E+  S     
Sbjct: 1125 -HLQASFGFQTFQPSGILL-------------DHQTWTRNLQVTLEDGYIELSTSDSGSP 1170

Query: 2606 MRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDE----NRRYMQNLTVEQPIEVKKLF 2661
            + K      P  + DG  H V V        + +D+    N + +++++  +    + L 
Sbjct: 1171 IFK-----SPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKRLKHISSSR----QSLR 1221

Query: 2662 VGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPM-----DFARPVSFKNADIGRCAHQK-- 2714
            +GG+              FEGCI N+ +  + +     D       ++  +G C+  K  
Sbjct: 1222 LGGSN-------------FEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPP 1268

Query: 2715 --------LREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQF 2766
                     R ++        ++Q  PV +P     +  +    C+   +     G+ QF
Sbjct: 1269 FLMLLKGSTRFNKTKTFRINQLLQDTPVASPR----SVKVWQDACSPLPKTQANHGALQF 1324

Query: 2767 GLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFS 2826
            G    SH+        +K R    ++++T +  GL+F+    N   F  + L  G   F+
Sbjct: 1325 GDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTGTKN--SFMALYLSKGRLVFA 1382

Query: 2827 YDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLY 2886
                          K NDG+WH +      ++G L VDG   R  S      + +   +Y
Sbjct: 1383 LGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAPVY 1442

Query: 2887 VGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-AQRGTYF- 2944
            +G  P   + +     T S  GC++N  +   P  L  P+SSF V +C     ++G YF 
Sbjct: 1443 LGSPP---SGKPKSLPTNSFVGCLKNFQLDSKP--LYTPSSSFGVSSCLGGPLEKGIYFS 1497

Query: 2945 DGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNG 3004
            +  G         +G +  + F  R  + TG+L+ I SQ    + + +   K+   +D+G
Sbjct: 1498 EEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQPGKHLCVYLEAGKVTASMDSG 1557

Query: 3005 AGRFTAVYDAGVPGHLCDGQWHKVTANKIKH--RIELTVDGNQVEAQSPNPASTSADTND 3062
            AG  +          LCDGQWH V     +H   +EL  D +    Q P P    A T +
Sbjct: 1558 AGGTST--SVTPKQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAGQIPFP---PASTQE 1612

Query: 3063 PVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVS---C 3119
            P+ +GG P +L    +     F GC+R++ +       + V   +ALE++G  PVS   C
Sbjct: 1613 PLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNH-----IPVPVTEALEVQG--PVSLNGC 1665

Query: 3120 P 3120
            P
Sbjct: 1666 P 1666



 Score =  139 bits (349), Expect = 6e-32
 Identities = 66/168 (39%), Positives = 94/168 (55%), Gaps = 13/168 (7%)

Query: 736 ESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGE 795
           + C P + R +  ++ G C PC C GH+  C D +G C+NC+ +T G +C++C  G+YG 
Sbjct: 57  QGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGN 116

Query: 796 PTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQP 855
              G+   C+ C CP    +N+F+  C ++   G +   C  GYTG +CERCA GYFG P
Sbjct: 117 AVHGS---CRACPCP---HTNSFATGCVVNG--GDVRCSCKAGYTGTQCERCAPGYFGNP 168

Query: 856 SVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP--GTTGRYCELC 901
              GGSCQPC CN N      GSC  L+G C+  +P   +    C+ C
Sbjct: 169 QKFGGSCQPCSCNSNGQL---GSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 54/161 (33%), Positives = 77/161 (47%), Gaps = 14/161 (8%)

Query: 847 CAEGYF-GQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGY 905
           C+ GY+     +  G C PC CN + +      C   SG C+ C+  T G +CE C +GY
Sbjct: 59  CSPGYYRDHKGLYTGRCVPCNCNGHSN-----QCQDGSGICVNCQHNTAGEHCERCQEGY 113

Query: 906 FGDAVDAKNCQPCRCNAGGSFSEVCHSQTG--QCECRANVQGQRCDKCKAGTFGLQSARG 963
           +G+AV   +C+ C C    SF+  C    G  +C C+A   G +C++C  G FG     G
Sbjct: 114 YGNAVHG-SCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFG 172

Query: 964 --CVPCNCNSFGSKSFDCEESGQCWCQ---PGVTGKKCDRC 999
             C PC+CNS G        +G C  Q        ++CD C
Sbjct: 173 GSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 91.7 bits (226), Expect = 1e-17
 Identities = 52/158 (32%), Positives = 74/158 (46%), Gaps = 17/158 (10%)

Query: 901  CADGYFGD--AVDAKNCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQGQRCDKCKAGTFG 957
            C+ GY+ D   +    C PC CN     S  C   +G C  C+ N  G+ C++C+ G +G
Sbjct: 59   CSPGYYRDHKGLYTGRCVPCNCNG---HSNQCQDGSGICVNCQHNTAGEHCERCQEGYYG 115

Query: 958  LQSARGCVPCNCNSFGSKSFDCEESG---QCWCQPGVTGKKCDRCAHGYFNFQE---GGC 1011
                  C  C C    S +  C  +G   +C C+ G TG +C+RCA GYF   +   G C
Sbjct: 116  NAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSC 175

Query: 1012 TACECSHLG--NNCDPKTGRCI---CPPNTIGEKCSKC 1044
              C C+  G   +C P TG CI      ++  E+C  C
Sbjct: 176  QPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 58/199 (29%), Positives = 79/199 (39%), Gaps = 43/199 (21%)

Query: 321 CCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCIN 380
           C PG++    R    L    C  CNC+G + +C                    G G+C+N
Sbjct: 59  CSPGYY----RDHKGLYTGRCVPCNCNGHSNQCQD------------------GSGICVN 96

Query: 381 CTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPG 440
           C  NTAG +CE C +G++            C+ C C    S    CV +    R      
Sbjct: 97  CQHNTAGEHCERCQEGYY-----GNAVHGSCRACPCPHTNSFATGCVVNGGDVR------ 145

Query: 441 SCHCKTGFGGVSCDRCARGYTGYP-----DCKACNCSGLGSKNE-DPCFGPCICKENVEG 494
            C CK G+ G  C+RCA GY G P      C+ C+C+  G      P  G CI +E  + 
Sbjct: 146 -CSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 204

Query: 495 G---DCSRCKSGFFNLQED 510
               +C  C S    L  D
Sbjct: 205 SPAEECDDCDSCVMTLLND 223



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 47/160 (29%), Positives = 72/160 (45%), Gaps = 15/160 (9%)

Query: 999  CAHGYFNFQEG----GCTACECSHLGNNCDPKTGRCI-CPPNTIGEKCSKCAPNTWGHSI 1053
            C+ GY+   +G     C  C C+   N C   +G C+ C  NT GE C +C    +G+++
Sbjct: 59   CSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAV 118

Query: 1054 TTGCKACNCSTVGSLDFQCNVNTG--QCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLP 1111
               C+AC C    S    C VN G  +C+C   ++G +C  C+ G++  P+      F  
Sbjct: 119  HGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQ-----KFGG 173

Query: 1112 GTDATTCDSETKKCSCSDQTGQC---TCKVNVEGIHCDRC 1148
                 +C+S  +  SC   TG C     K +     CD C
Sbjct: 174  SCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDC 213



 Score = 62.0 bits (149), Expect = 9e-09
 Identities = 37/119 (31%), Positives = 49/119 (41%), Gaps = 14/119 (11%)

Query: 1054 TTGCKACNCSTVGSLDFQCNVNTGQC-NCHPKFSGAKCTECSRGHWN---YPRCNLCDCF 1109
            T  C  CNC+   +   QC   +G C NC    +G  C  C  G++    +  C  C C 
Sbjct: 72   TGRCVPCNCNGHSN---QCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPC- 127

Query: 1110 LPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC 1168
             P T+     S    C  +    +C+CK    G  C+RC PG FG   K    C  C C
Sbjct: 128  -PHTN-----SFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSC 180



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 48/180 (26%), Positives = 62/180 (34%), Gaps = 54/180 (30%)

Query: 274 YYYSVKDISVGGM--CICYGHARACPLDPATNKSRC-ECEHNTCGDSCDQCCPGFHQKPW 330
           YY   K +  G    C C GH+  C          C  C+HNT G+ C++C  G++    
Sbjct: 63  YYRDHKGLYTGRCVPCNCNGHSNQCQ----DGSGICVNCQHNTAGEHCERCQEGYYGN-- 116

Query: 331 RAGTFLTKTECEACNC---HGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAG 387
                     C AC C   +  A  C  +                 GG V  +C     G
Sbjct: 117 -----AVHGSCRACPCPHTNSFATGCVVN-----------------GGDVRCSCKAGYTG 154

Query: 388 INCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTG 447
             CE C  G+F   G    +   CQPC C+  G L                 GSCH  TG
Sbjct: 155 TQCERCAPGYF---GNPQKFGGSCQPCSCNSNGQL-----------------GSCHPLTG 194



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 30/69 (43%), Positives = 37/69 (53%), Gaps = 5/69 (7%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQC--FGHAESCDDVTGECLN--CKDH 779
           C C  GYTG+ CE C P +   N   FGG C+PC C   G   SC  +TG+C+N   KD 
Sbjct: 146 CSCKAGYTGTQCERCAPGYFG-NPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 204

Query: 780 TGGPYCDKC 788
           +    CD C
Sbjct: 205 SPAEECDDC 213



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 49/180 (27%), Positives = 69/180 (38%), Gaps = 32/180 (17%)

Query: 393 CTDGFFRP-KGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC-HCKTGFGG 450
           C+ G++R  KG+   Y   C PC+C+  G  N+   +D          G C +C+    G
Sbjct: 59  CSPGYYRDHKGL---YTGRCVPCNCN--GHSNQC--QD--------GSGICVNCQHNTAG 103

Query: 451 VSCDRCARGYTG---YPDCKACNCSGLGSKNEDPCFGP----CICKENVEGGDCSRCKSG 503
             C+RC  GY G   +  C+AC C    S             C CK    G  C RC  G
Sbjct: 104 EHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPG 163

Query: 504 FFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMSGWYLTDLPGRIRVAPQQDDLDS 563
           +F   +     C  C C        +S    G    ++G  +   P     A + DD DS
Sbjct: 164 YFGNPQKFGGSCQPCSC--------NSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDS 215



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 23/99 (23%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL--CDPETSIC 1436
            +C C  GY+G  CE C PG++          P    G+C PC CN +  L  C P T  C
Sbjct: 145  RCSCKAGYTGTQCERCAPGYF--------GNPQKFGGSCQPCSCNSNGQLGSCHPLTGDC 196

Query: 1437 QNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLIS 1475
             N Q        E C            +DC  C   L++
Sbjct: 197  IN-QEPKDSSPAEEC------------DDCDSCVMTLLN 222



 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 40/131 (30%), Positives = 49/131 (37%), Gaps = 24/131 (18%)

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRT-PGP-TLGTCVPCQCNGHSSLCDPETSICQN 1438
            +C    +G  CE C  G+Y        R  P P T      C  NG    C        +
Sbjct: 96   NCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRC--------S 147

Query: 1439 CQHHTAGDFCERCALGYYGIVKGLPNDCQQCAC----------PLISSSNNFSP--SCVA 1486
            C+    G  CERCA GY+G  +     CQ C+C          PL     N  P  S  A
Sbjct: 148  CKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPA 207

Query: 1487 EGLDDYRCTAC 1497
            E  DD  C +C
Sbjct: 208  EECDD--CDSC 216


>gi|119703755 laminin, beta 2 precursor [Homo sapiens]
          Length = 1798

 Score =  404 bits (1038), Expect = e-112
 Identities = 350/1221 (28%), Positives = 498/1221 (40%), Gaps = 189/1221 (15%)

Query: 52   ITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNS-----SNPNQRHPITNAIDG- 105
            +T ++TCG  GP+ YC +V H+  +     +C +C+         NP+  H I N +   
Sbjct: 62   LTASSTCGLNGPQPYC-IVSHLQDEK----KCFLCDSRRPFSARDNPHS-HRIQNVVTSF 115

Query: 106  ----KNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDV 161
                +  WWQS   +NGI    VTI LDL+  F   ++I+    + RP   ++ERS D  
Sbjct: 116  APQRRAAWWQS---ENGIPA--VTIQLDLEAEFHFTHLIM-TFKTFRPAAMLVERSADFG 169

Query: 162  EYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLING 221
              + W  +     +C   +   P   P  +   D+V+C S YS+I P   GE+   +++ 
Sbjct: 170  --RTWHVYRYFSYDCGADFPGVPLAPPRHW---DDVVCESRYSEIEPSTEGEVIYRVLDP 224

Query: 222  RPSADDP-SPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKD 280
                 DP S  +        +R+   R+ TL  +L+     DPR     +  +YYY++ +
Sbjct: 225  AIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLL-----DPRRE---IREKYYYALYE 276

Query: 281  ISVGGMCICYGHARACPLDPATNK-------SRCECEHNTCGDSCDQCCPGFHQKPWRAG 333
            + V G C CYGHA  C   P             C C+HNT G +C+QC   +   PWR  
Sbjct: 277  LVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPA 336

Query: 334  TFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETC 393
                   C  C CHG    C++D       +++ +    + GGVC  C  NTAG +CE C
Sbjct: 337  EDGHSHACRKCECHGHTHSCHFD-------MAVYLASGNVSGGVCDGCQHNTAGRHCELC 389

Query: 394  TDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKT------- 446
               F+R        P  C+ C CDP+GS +            GL  G C CK        
Sbjct: 390  RPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRC 449

Query: 447  -----GFGGVS------CDRCARGYTGY--------PDCKACNCSGLGS-KNEDPCF-GP 485
                 GF G+S      C RC     G         P+  +C C  L + +  D C  G 
Sbjct: 450  QQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGH 509

Query: 486  CICKENVEGGDCSRCK---SGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGK-IQDMS 541
                 ++ G  C  C     G  + Q D   G   C    V  RC+     Y +   D  
Sbjct: 510  WGLSHDLLG--CRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYFRPFLDHL 567

Query: 542  GWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQ 601
             W   D  G++        LD  +++ ++  E        +        L   + +V   
Sbjct: 568  IWEAEDTRGQV--------LDVVERL-VTPGETPSWTGSGFVRLQEGQTLEFLVASVPKA 618

Query: 602  LTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFT 661
            + + +   LE +  +    L+L++   G   + S      +L P ++     L     + 
Sbjct: 619  MDYDLLLRLEPQVPEQWAELELIVQRPGPVPAHSLCG---HLVPKDDRIQGTLQPHARYL 675

Query: 662  IHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPT-------D 714
            I     PV  +  ++   +LK  L++   S   +  +    + ++S V  P         
Sbjct: 676  IFPN--PVCLEPGISYKLHLK--LVRTGGSAQPETPYSGPGLLIDSLVLLPRVLVLEMFS 731

Query: 715  GSIAAAVEV------CQCP-----PGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGH- 762
            G  AAA+E        QC      P  T  S E+C P    ++  I+ G   PCQC    
Sbjct: 732  GGDAAALERQATFERYQCHEEGLVPSKTSPS-EACAPLLISLSTLIYNGAL-PCQCNPQG 789

Query: 763  --AESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSP 820
              +  C+   G+CL CK    G  CD C PG+YG    G    CQ C C         S 
Sbjct: 790  SLSSECNPHGGQCL-CKPGVVGRRCDLCAPGYYGFGPTG----CQACQCS---HEGALSS 841

Query: 821  TCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCD 880
             C       L    C  G  G RC+RC  G +G PS     C+PC CN + D      C+
Sbjct: 842  LCEKTSGQCL----CRTGAFGLRCDRCQRGQWGFPS-----CRPCVCNGHAD-----ECN 887

Query: 881  SLSGSCLICKPGTTGRYCELCADGYFGDA--VDAKNCQPCRCNAG-GS---FSEVCH--- 931
            + +G+CL C+  T G +CE C  G+ GD        C+PC C  G GS   F+  CH   
Sbjct: 888  THTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDE 947

Query: 932  -SQTGQCECRANVQGQRCDKCKAGTFGLQSARG--CVPCNC--NSFGSKSFDCE-ESGQC 985
             SQ   C CRA   G RC+ C  G FG  S  G  C  C C  N        C+  +GQC
Sbjct: 948  YSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQC 1007

Query: 986  W-CQPGVTGKKCDRCAHGYFN-FQEGGCTACECSHLGNN-----------CDPKTGRCIC 1032
              C     G  C  C  G+        C  C C+ LG N           CDP +G+C C
Sbjct: 1008 LRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPC 1067

Query: 1033 PPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE 1092
             PN  G  C +CAPN W  +   GC+ C C    +    CN  TGQC+C   F G  C+E
Sbjct: 1068 LPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSE 1127

Query: 1093 CSRGHWNYP--RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRP 1150
            C   HW  P  +C+ CDC   G D            C   TG C+C+  V G+ CD+C  
Sbjct: 1128 CQELHWGDPGLQCHACDCDSRGIDTP---------QCHRFTGHCSCRPGVSGVRCDQCAR 1178

Query: 1151 GKFGLDAKNPLGCSSCY-CFG 1170
            G  G+       C  C+ CFG
Sbjct: 1179 GFSGIFP----ACHPCHACFG 1195



 Score =  159 bits (402), Expect = 4e-38
 Identities = 93/277 (33%), Positives = 127/277 (45%), Gaps = 29/277 (10%)

Query: 917  PCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKS 976
            PC+CN  GS S  C+   GQC C+  V G+RCD C  G +G     GC  C C+  G+ S
Sbjct: 782  PCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDLCAPGYYGF-GPTGCQACQCSHEGALS 840

Query: 977  FDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCI-CPP 1034
              CE+ SGQC C+ G  G +CDRC  G + F    C  C C+   + C+  TG C+ C  
Sbjct: 841  SLCEKTSGQCLCRTGAFGLRCDRCQRGQWGFPS--CRPCVCNGHADECNTHTGACLGCRD 898

Query: 1035 NTIGEKCSKCAPNTWGHS-ITTG--CKACNCSTVGSLDFQCNVNTGQ--------CNCHP 1083
            +T GE C +C     G   +  G  C+ C C            +  Q        C+C  
Sbjct: 899  HTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRA 958

Query: 1084 KFSGAKCTECSRGHWNYP-----RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT-CK 1137
             ++G +C  C+ GH+  P     RC LC+C     +    D +    +C   TGQC  C 
Sbjct: 959  GYTGLRCEACAPGHFGDPSRPGGRCQLCEC---SGNIDPMDPD----ACDPHTGQCLRCL 1011

Query: 1138 VNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQ 1174
             + EG HC  C+PG  G  A+      +C   GT  Q
Sbjct: 1012 HHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTNPQ 1048



 Score =  133 bits (334), Expect = 3e-30
 Identities = 188/834 (22%), Positives = 317/834 (38%), Gaps = 112/834 (13%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGH-----SSLCDPETS 1434
            C C  GY+GL CEAC PG +   S+PGGR        C  C+C+G+        CDP T 
Sbjct: 954  CHCRAGYTGLRCEACAPGHFGDPSRPGGR--------CQLCECSGNIDPMDPDACDPHTG 1005

Query: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPS---CVAEGLDD 1491
             C  C HHT G  C  C  G++G  +     C +C C L+ ++    PS   C  +    
Sbjct: 1006 QCLRCLHHTEGPHCAHCKPGFHG--QAARQSCHRCTCNLLGTNPQQCPSPDQCHCDP-SS 1062

Query: 1492 YRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPG 1551
             +C   P   +G  C+RCAP +       G  CQ C C P  +    C+  TG C CR G
Sbjct: 1063 GQCPCLP-NVQGPSCDRCAPNFWNL--TSGHGCQPCACHPSRARGPTCNEFTGQCHCRAG 1119

Query: 1552 ATGRKCDGCK--HWHAREGWECVFCGDECTGL-------LLGDLA--------RLEQMVM 1594
              GR C  C+  HW    G +C  C  +  G+         G  +        R +Q   
Sbjct: 1120 FGGRTCSECQELHW-GDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCAR 1178

Query: 1595 SINLTGPLPAPYKMLYG-LENMTQELKHLLSPQRAPERLIQLAE----GNLNTLVTEMNE 1649
              +   P   P    +G  + + Q+L      QR  +R  +L +    G   +    M E
Sbjct: 1179 GFSGIFPACHPCHACFGDWDRVVQDL--AARTQRLEQRAQELQQTGVLGAFESSFWHMQE 1236

Query: 1650 LLTRATKV----TADGEQTGQDAERTNTRAKSLG---EFIKELARDAEAVNEKAIKLNET 1702
             L     +          T Q  E T    + +G   E + +L  D   V ++    N  
Sbjct: 1237 KLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFNANHA 1296

Query: 1703 L-GTRDEAFERNLEGLQKEIDQMIKELRRKN-LETQKEIAEDELVAAEALLK-KVKKLFG 1759
            L G   +    NL    +++DQ +  L+  N L     I      +AEA  +     L  
Sbjct: 1297 LSGLERDRLALNL--TLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSALAV 1354

Query: 1760 ESRGENEEMEKDLREKLADYKNKVDDAWDLLRE-ATDKIREANRLFAVNQKNMTALEKKK 1818
             S   N    +   E L D + +  ++  +  + A  K+       ++   N        
Sbjct: 1355 PSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPG 1414

Query: 1819 EAV-------ESGKRQIENTLKEGNDILDEANRLADEINSIIDYVE-DIQTKLPPMSEEL 1870
            +A         +G R  +   + G    + A   AD       + + ++Q  L      L
Sbjct: 1415 DAPCATSPCGGAGCRDEDGQPRCGGLSCNGAAATADLALGRARHTQAELQRALAEGGSIL 1474

Query: 1871 NDKIDDLSQEIKDRKLAE-KVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYS 1929
            +   +   Q  + ++ A+  + +A +   Q+  ++  L  ++   K+      A   +  
Sbjct: 1475 SRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIE 1534

Query: 1930 NIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDA-----KGCLQKSFRILNEAKKL 1984
             +   + E   +   A+ + H A  +A   R L   DA      G ++++ ++L +A++ 
Sbjct: 1535 MVATRVLEL-SIPASAEQIQHLAGAIAERVRSLADVDAILARTVGDVRRAEQLLQDARRA 1593

Query: 1985 ANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDK---A 2041
             +  ++ +     ++  +E A    G     +   +    A   DT   L  V+++   A
Sbjct: 1594 RSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAV----ADTRDTEQTLYQVQERMAGA 1649

Query: 2042 RQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNA-------------------- 2081
             +A  +A +   Q+  L + L  LK+  N LA S A+  A                    
Sbjct: 1650 ERALSSAGERARQLDALLEALK-LKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLGD 1708

Query: 2082 ---VVKDPSKNKI--IADADATVKNLEQEADRLI----DKLKPIKELEDNLKKN 2126
                VK  ++ K   +  A A  + L  EA  L+    DKL+ ++ELE   ++N
Sbjct: 1709 QYQTVKALAERKAQGVLAAQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEEN 1762



 Score =  129 bits (324), Expect = 5e-29
 Identities = 73/191 (38%), Positives = 88/191 (46%), Gaps = 24/191 (12%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            +C C  G  GL C+ C  G +   S             C PC CNGH+  C+  T  C  
Sbjct: 849  QCLCRTGAFGLRCDRCQRGQWGFPS-------------CRPCVCNGHADECNTHTGACLG 895

Query: 1439 CQHHTAGDFCERCALGYYGIVKGLP--NDCQQCACPL-ISSSNNFSPSCVAEGLDDYRCT 1495
            C+ HT G+ CERC  G++G  + LP    C+ C CP    S  +F+ SC  +        
Sbjct: 896  CRDHTGGEHCERCIAGFHGDPR-LPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVC 954

Query: 1496 ACPRGYEGQYCERCAPGYTGSPGNPGGSCQECEC----DPYGSLPVPCDPVTGFC-TCRP 1550
             C  GY G  CE CAPG+ G P  PGG CQ CEC    DP    P  CDP TG C  C  
Sbjct: 955  HCRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPMD--PDACDPHTGQCLRCLH 1012

Query: 1551 GATGRKCDGCK 1561
               G  C  CK
Sbjct: 1013 HTEGPHCAHCK 1023



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 66/205 (32%), Positives = 90/205 (43%), Gaps = 25/205 (12%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSI---- 1435
            C C     GL+CE C   FYR    P           C  C+C+GH+  C  + ++    
Sbjct: 310  CICKHNTRGLNCEQC-QDFYR--DLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLAS 366

Query: 1436 -------CQNCQHHTAGDFCERCALGYY-GIVKGL--PNDCQQCACPLISSSNNF---SP 1482
                   C  CQH+TAG  CE C   +Y    K L  P  C+ C C  + S +     S 
Sbjct: 367  GNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSH 426

Query: 1483 SCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP--VPCD 1540
               A GL   +C  C     G  C++C  G+ G   +    C+ C+C+  G++P   PCD
Sbjct: 427  DDPALGLVSGQCR-CKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCD 485

Query: 1541 PVTGFCTCRPGATGRKCDGC--KHW 1563
            P +G C C+   TGR CD C   HW
Sbjct: 486  PNSGSCYCKRLVTGRGCDRCLPGHW 510



 Score = 85.9 bits (211), Expect = 6e-16
 Identities = 68/242 (28%), Positives = 94/242 (38%), Gaps = 54/242 (22%)

Query: 983  GQCWCQPGVTGKKCDRCAHGYFNF-----QEG---GCTACECSHLGNNC----------- 1023
            G C C+    G  C++C   Y +      ++G    C  CEC    ++C           
Sbjct: 308  GACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASG 367

Query: 1024 DPKTGRCI-CPPNTIGEKCSKCAPNTWGHSIT-----TGCKACNCSTVGSLDF-QCNVN- 1075
            +   G C  C  NT G  C  C P  +            C++C+C  +GS D  +C+ + 
Sbjct: 368  NVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHD 427

Query: 1076 -------TGQCNCHPKFSGAKCTECSRGHWNYP-----RCNLCDCFLPGT--DATTCDSE 1121
                   +GQC C     G +C +C  G +         C  C C   GT   +T CD  
Sbjct: 428  DPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPN 487

Query: 1122 TKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC---FGTTTQCSEA 1178
            +         G C CK  V G  CDRC PG +GL + + LGC  C C        QC E 
Sbjct: 488  S---------GSCYCKRLVTGRGCDRCLPGHWGL-SHDLLGCRPCDCDVGGALDPQCDEG 537

Query: 1179 KG 1180
             G
Sbjct: 538  TG 539



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 58/191 (30%), Positives = 81/191 (42%), Gaps = 23/191 (12%)

Query: 1380 CD-CPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CD---- 1430
            CD C    +G  CE C P FYR    P      P +  C  C C+   S     CD    
Sbjct: 374  CDGCQHNTAGRHCELCRPFFYR---DPTKDLRDPAV--CRSCDCDPMGSQDGGRCDSHDD 428

Query: 1431 PETSICQN---CQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAE 1487
            P   +      C+ H  G  C++C  G++G+       C++C C    +    +P     
Sbjct: 429  PALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNS 488

Query: 1488 GLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCT 1547
            G        C R   G+ C+RC PG+ G   +  G C+ C+CD  G+L   CD  TG C 
Sbjct: 489  G-----SCYCKRLVTGRGCDRCLPGHWGLSHDLLG-CRPCDCDVGGALDPQCDEGTGQCH 542

Query: 1548 CRPGATGRKCD 1558
            CR    GR+C+
Sbjct: 543  CRQHMVGRRCE 553



 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 68/217 (31%), Positives = 82/217 (37%), Gaps = 61/217 (28%)

Query: 1418 VPCQCNGHSSL---CDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCAC--- 1471
            +PCQCN   SL   C+P    C  C+    G  C+ CA GYYG     P  CQ C C   
Sbjct: 781  LPCQCNPQGSLSSECNPHGGQCL-CKPGVVGRRCDLCAPGYYGFG---PTGCQACQCSHE 836

Query: 1472 -PLISSSNNFSPSCVAE-GLDDYRCTACPRGY---------------------------- 1501
              L S     S  C+   G    RC  C RG                             
Sbjct: 837  GALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGC 896

Query: 1502 ----EGQYCERCAPGYTGSPGNP-GGSCQECECDPYG-----SLPVPC--DPVTG--FCT 1547
                 G++CERC  G+ G P  P GG C+ C C P G          C  D  +    C 
Sbjct: 897  RDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPC-PEGPGSQRHFATSCHQDEYSQQIVCH 955

Query: 1548 CRPGATGRKCDGCKHWH----AREGWECVFCGDECTG 1580
            CR G TG +C+ C   H    +R G  C  C  EC+G
Sbjct: 956  CRAGYTGLRCEACAPGHFGDPSRPGGRCQLC--ECSG 990



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 53/146 (36%), Positives = 65/146 (44%), Gaps = 21/146 (14%)

Query: 1457 GIVKGLPNDCQQCACPLISSS----NNFSP-SCVAEGLDDYRCTA------CPRGYEGQY 1505
            G+V    +  + CA  LIS S    N   P  C  +G     C        C  G  G+ 
Sbjct: 753  GLVPSKTSPSEACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRR 812

Query: 1506 CERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCK--HW 1563
            C+ CAPGY G    P G CQ C+C   G+L   C+  +G C CR GA G +CD C+   W
Sbjct: 813  CDLCAPGYYGF--GPTG-CQACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQW 869

Query: 1564 HAREGWECVFCG--DEC---TGLLLG 1584
                   CV  G  DEC   TG  LG
Sbjct: 870  GFPSCRPCVCNGHADECNTHTGACLG 895



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 47/171 (27%), Positives = 70/171 (40%), Gaps = 29/171 (16%)

Query: 1420 CQCNGHSSLCDPETSICQN----------CQHHTAGDFCERCA-----LGYYGIVKGLPN 1464
            C C GH+S C P      +          C+H+T G  CE+C      L +     G  +
Sbjct: 283  CFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSH 342

Query: 1465 DCQQCACPLISSSNNFSPSC-VAEG-LDDYRCTACPRGYEGQYCERCAPGYTGSPG---N 1519
             C++C C   + S +F  +  +A G +    C  C     G++CE C P +   P     
Sbjct: 343  ACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLR 402

Query: 1520 PGGSCQECECDPYGSLP-VPCDP--------VTGFCTCRPGATGRKCDGCK 1561
                C+ C+CDP GS     CD         V+G C C+    G +C  C+
Sbjct: 403  DPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCR 453



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 42/140 (30%), Positives = 58/140 (41%), Gaps = 22/140 (15%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGH-----SSLCDPET 1433
            +C C     G  C+ C  GF+       G +    LG C  CQCN       S+ CDP +
Sbjct: 437  QCRCKEHVVGTRCQQCRDGFF-------GLSISDRLG-CRRCQCNARGTVPGSTPCDPNS 488

Query: 1434 SICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYR 1493
              C  C+    G  C+RC  G++G+   L   C+ C C +        P C  EG     
Sbjct: 489  GSCY-CKRLVTGRGCDRCLPGHWGLSHDLLG-CRPCDCDV---GGALDPQC-DEGTGQCH 542

Query: 1494 CTACPRGYEGQYCERCAPGY 1513
            C    +   G+ CE+  PGY
Sbjct: 543  CR---QHMVGRRCEQVQPGY 559



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 39/146 (26%), Positives = 56/146 (38%), Gaps = 36/146 (24%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN---GHSSLCDPETSI 1435
            +C C     G SC+ C P F+ L S  G          C PC C+        C+  T  
Sbjct: 1064 QCPCLPNVQGPSCDRCAPNFWNLTSGHG----------CQPCACHPSRARGPTCNEFTGQ 1113

Query: 1436 CQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC- 1494
            C +C+    G  C  C   ++G   GL   C  C              C + G+D  +C 
Sbjct: 1114 C-HCRAGFGGRTCSECQELHWG-DPGL--QCHAC-------------DCDSRGIDTPQCH 1156

Query: 1495 -----TACPRGYEGQYCERCAPGYTG 1515
                  +C  G  G  C++CA G++G
Sbjct: 1157 RFTGHCSCRPGVSGVRCDQCARGFSG 1182



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/96 (32%), Positives = 40/96 (41%), Gaps = 15/96 (15%)

Query: 1366 RGTT--MTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN 1423
            RGT    TP       C C    +G  C+ CLPG + L     G         C PC C+
Sbjct: 475  RGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLG---------CRPCDCD 525

Query: 1424 GHSSL---CDPETSICQNCQHHTAGDFCERCALGYY 1456
               +L   CD  T  C +C+ H  G  CE+   GY+
Sbjct: 526  VGGALDPQCDEGTGQC-HCRQHMVGRRCEQVQPGYF 560



 Score = 39.3 bits (90), Expect = 0.062
 Identities = 51/226 (22%), Positives = 92/226 (40%), Gaps = 36/226 (15%)

Query: 1644 VTEMNELLTRATKVTADGEQTGQDAERTNTRA---KSLGEFIK---ELARDAEAVNEKAI 1697
            + +++ +L R        EQ  QDA R  + A   K   E ++   E A+ A+ + + AI
Sbjct: 1566 LADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAI 1625

Query: 1698 KLNETLGTRDEAFERNLEGLQKEIDQMIKEL-----RRKNLETQKEIAEDELVAAEALLK 1752
            +      TRD   E+ L  +Q+ +    + L     R + L+   E  + +         
Sbjct: 1626 R-GAVADTRDT--EQTLYQVQERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAAS 1682

Query: 1753 KVKKLFGESRGENEEMEKDLREKLADYKNKV----------------------DDAWDLL 1790
              ++  G ++G  +E E+ LR  L D    V                      D+A DLL
Sbjct: 1683 TAEETAGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLAAQARAEQLRDEARDLL 1742

Query: 1791 REATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGN 1836
            + A DK++    L    ++N  ALE K   ++  + ++ + L+  N
Sbjct: 1743 QAAQDKLQRLQELEGTYEENERALESKAAQLDGLEARMRSVLQAIN 1788



 Score = 36.6 bits (83), Expect = 0.40
 Identities = 69/363 (19%), Positives = 137/363 (37%), Gaps = 56/363 (15%)

Query: 1697 IKLNETLGTRDEAFERNLEGLQKEIDQMIKE---LRRKNLETQKEIAEDELVAAEALLKK 1753
            +  N    T D A  R     Q E+ + + E   +  +  ET+++ +E +   A+A L K
Sbjct: 1440 LSCNGAAATADLALGR-ARHTQAELQRALAEGGSILSRVAETRRQASEAQQ-RAQAALDK 1497

Query: 1754 VKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTA 1813
                 G+    N+E++ +L + + D+ N+     D +     ++ E +   +  Q    A
Sbjct: 1498 ANASRGQVEQANQELQ-ELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASAEQIQHLA 1556

Query: 1814 ---LEKKKEA--VESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSE 1868
                E+ +    V++   +    ++    +L +A R            E +Q  L     
Sbjct: 1557 GAIAERVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAALEEAQR 1616

Query: 1869 ELNDKIDDLSQEIKDRK--------LAEKVSQAESHAAQLNDSSAVLDGILDEAK-NISF 1919
                    +   + D +        + E+++ AE   +   + +  LD +L+  K   + 
Sbjct: 1617 AQGIAQGAIRGAVADTRDTEQTLYQVQERMAGAERALSSAGERARQLDALLEALKLKRAG 1676

Query: 1920 NATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRG------------------ 1961
            N+ AA             AE+ A  A+  A EA +L  GP G                  
Sbjct: 1677 NSLAA-----------STAEETAGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVL 1725

Query: 1962 -------LLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLR 2014
                    L+++A+  LQ +   L   ++L    +ENE  L     +++  +AR   +L+
Sbjct: 1726 AAQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALESKAAQLDGLEARMRSVLQ 1785

Query: 2015 TLN 2017
             +N
Sbjct: 1786 AIN 1788


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  358 bits (920), Expect = 4e-98
 Identities = 214/567 (37%), Positives = 274/567 (48%), Gaps = 43/567 (7%)

Query: 981  ESGQCWCQPGVTGKKCDRCAHGYFNFQEG----GCTACECSHLGNNCDPKTGRCI-CPPN 1035
            E  QC C PG  G  C  C  GY     G     C  C C      C+P+TG C  C  +
Sbjct: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHH 1181

Query: 1036 TIGEKCSKCAPNTWGHS---ITTGCKACNC---STVGSLDFQCNVNTG---QCN-CHPKF 1085
            T G +C +C P  +G +       C+ C C      G     C ++T     C+ C P  
Sbjct: 1182 TEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGH 1241

Query: 1086 SGAKCTECSRGHWNYPR----CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVE 1141
            SG  C  C+ G++  P     C   D  +PG     CD +    S  D  GQC CK  VE
Sbjct: 1242 SGRHCERCAPGYYGNPSQGQPCQR-DSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVE 1300

Query: 1142 GIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEA---KGLIRTWVTLKAEQTILPLV 1198
            G+ C  CRP  F L A NP GC  C+C G T QC+ +   + LI T       Q    + 
Sbjct: 1301 GLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVN 1360

Query: 1199 DEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIY 1258
             +     T +  V   PE           L  E FYW+LPE ++G K+ AYGGKL+Y + 
Sbjct: 1361 PQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLS 1420

Query: 1259 FEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDP 1318
            + A  + G    +P V I G       ++V    A    +   +EI   E+ W+     P
Sbjct: 1421 YTAGPQ-GSPLSDPDVQITGNNI----MLVASQPALQGPERRSYEIMFREEFWRRPDGQP 1475

Query: 1319 RVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIE 1378
                  TRE  L  L D+  +LI+AT+ +    + IS +S+EVA+ G      P A  +E
Sbjct: 1476 -----ATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNR--PRALEVE 1528

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            +C CP GY GLSC+ C PG+ R  S       G  LG C  C+CNGHS LC PET  C  
Sbjct: 1529 ECRCPPGYIGLSCQDCAPGYTRTGS-------GLYLGHCELCECNGHSDLCHPETGACSQ 1581

Query: 1439 CQHHTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
            CQH+ AG+FCE CA GYYG    G P DCQ CACPL +  N FS +C + G   YRCTAC
Sbjct: 1582 CQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTAC 1641

Query: 1498 PRGYEGQYCERCAPGYTGSPGNPGGSC 1524
              GY GQYCE+C PGY G+P   GG C
Sbjct: 1642 EPGYTGQYCEQCGPGYVGNPSVQGGQC 1668



 Score =  331 bits (848), Expect = 8e-90
 Identities = 199/590 (33%), Positives = 275/590 (46%), Gaps = 61/590 (10%)

Query: 299  DPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDEN 358
            DPA    +C C     G SC  C  G+ + P  +G +L    CE C+CHG +E C  +  
Sbjct: 1118 DPALEVEQCSCPPGYRGPSCQDCDTGYTRTP--SGLYLGT--CERCSCHGHSEACEPET- 1172

Query: 359  VARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQ--PCHC 416
                             G C  C  +T G  CE C  G++         P+ CQ  PC+ 
Sbjct: 1173 -----------------GACQGCQHHTEGPRCEQCQPGYYGD--AQRGTPQDCQLCPCYG 1213

Query: 417  DPI-GSLNEVCVKD-EKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD----CK--- 467
            DP  G     C  D + H      P    C  G  G  C+RCA GY G P     C+   
Sbjct: 1214 DPAAGQAAHTCFLDTDGH------PTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDS 1267

Query: 468  ------ACNCSGLGS-KNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
                   CNC   GS  ++    G C CK  VEG  CS C+   F+L   N  GC  CFC
Sbjct: 1268 QVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327

Query: 521  SGVSNRCQSSYWTYGKIQ------DMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEA 574
             G++ +C SS +T   I       D  G+ L +     R+  +      P+   +S    
Sbjct: 1328 MGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNF 1387

Query: 575  RQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSI 634
             Q    S+YW  P  Y G+K+ A GG+L +T+SY    +           + + GN++ +
Sbjct: 1388 AQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLS---DPDVQITGNNIML 1444

Query: 635  STAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGM 694
              +Q    L   E  +  ++ +EE F       P  R+  +  LA+L  +L++ T+S  +
Sbjct: 1445 VASQPA--LQGPERRSYEIMFREE-FWRRPDGQPATREHLLMALADLDELLIRATFS-SV 1500

Query: 695  DAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC 754
                 +S+V+LE A   P++   A  VE C+CPPGY G SC+ C P + R    ++ G C
Sbjct: 1501 PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC 1560

Query: 755  EPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIP 814
            E C+C GH++ C   TG C  C+ +  G +C+ C PG+YG+ T GT EDCQPCACPL  P
Sbjct: 1561 ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP 1620

Query: 815  SNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQP 864
             N FS TC    + G  C  C  GYTG  CE+C  GY G PSV GG C P
Sbjct: 1621 ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLP 1670



 Score =  327 bits (838), Expect = 1e-88
 Identities = 203/613 (33%), Positives = 285/613 (46%), Gaps = 63/613 (10%)

Query: 984  QCWCQPGVTGKKCDRCAHGYFNFQEGG-----CTACECSHLGNNCDPKTGRCI-CPPNTI 1037
            +C C  G +G  C+ C   +F    GG     C+ C C+   ++CDP  G C+ C  NT 
Sbjct: 730  ECRCPIGYSGLSCESC-DAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTE 788

Query: 1038 GEKCSKCAPNTWGHSI---TTGCKACNCSTVGS---LDFQCNVNT-GQCNCH---PKFSG 1087
            G +C+KC    +G ++    T C+ C C  + +       C ++T GQ  C    P ++G
Sbjct: 789  GPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTG 848

Query: 1088 AKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQ----CTCKVNVEGI 1143
             +C  C+ G+   P         PG      + E  +C      G     C CK NV G 
Sbjct: 849  RRCESCAPGYEGNP-------IQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGR 901

Query: 1144 HCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQ 1203
             C+ C  G F L  +NP GC  C+C G +  C+ +            E     L + A  
Sbjct: 902  LCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAST 961

Query: 1204 HTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEARE 1263
            HTT +GI    P  +      R  L   P++W LP +F G K+ +YGG+L++ +   ++ 
Sbjct: 962  HTTNEGIFSPTPGELGFSSFHR--LLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQP 1019

Query: 1264 ETGFSTYNPQVIIRGGTPTHARIIVRHMAA--PLIGQLTRHEIEMTEKEWKYYGDDPRVH 1321
             +      P V+++G       II+ H  A  P  GQ +   +   E+ W+     P   
Sbjct: 1020 GSTPLHGQPLVVLQGN-----NIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQP--- 1071

Query: 1322 RTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCD 1381
               TRE  L  L  I  +LI+A+Y     +SR+S ISM+VA      T   PA  +E+C 
Sbjct: 1072 --ATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEE--TGQDPALEVEQCS 1127

Query: 1382 CPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQH 1441
            CP GY G SC+ C  G+ R  S       G  LGTC  C C+GHS  C+PET  CQ CQH
Sbjct: 1128 CPPGYRGPSCQDCDTGYTRTPS-------GLYLGTCERCSCHGHSEACEPETGACQGCQH 1180

Query: 1442 HTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG 1500
            HT G  CE+C  GYYG   +G P DCQ C C    ++   + +C  +      C AC  G
Sbjct: 1181 HTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPG 1240

Query: 1501 YEGQYCERCAPGYTGSPGNPGGSCQE---------CECDPYGSLPVPCDPVTGFCTCRPG 1551
            + G++CERCAPGY G+P + G  CQ          C CDP GS+   CD   G C C+  
Sbjct: 1241 HSGRHCERCAPGYYGNP-SQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQCQCKAQ 1298

Query: 1552 ATGRKCDGCKHWH 1564
              G  C  C+  H
Sbjct: 1299 VEGLTCSHCRPHH 1311



 Score =  314 bits (805), Expect = 8e-85
 Identities = 203/650 (31%), Positives = 296/650 (45%), Gaps = 77/650 (11%)

Query: 301  ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
            A +   C C     G SC+ C   F + P   G +L    C  CNC+G A  C   + V 
Sbjct: 725  AHSVEECRCPIGYSGLSCESCDAHFTRVP--GGPYLGT--CSGCNCNGHASSC---DPVY 777

Query: 361  RRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIG 420
                           G C+NC  NT G  C  C  GFF     +      C+PC C  I 
Sbjct: 778  ---------------GHCLNCQHNTEGPQCNKCKAGFFGDAMKAT--ATSCRPCPCPYID 820

Query: 421  S---LNEVCVKDEKHARRGLAPGSCH-CKTGFGGVSCDRCARGYTGYP-----DCKACN- 470
            +    ++ C  D           +C  C  G+ G  C+ CA GY G P      C+  N 
Sbjct: 821  ASRRFSDTCFLDTD------GQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQ 874

Query: 471  ----CSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNR 526
                C   GS         C CK NV G  C+ C  G F+L   N  GC +CFC GVS  
Sbjct: 875  EIVRCDERGSMGTSG--EACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRH 932

Query: 527  CQSSYWTYGKIQDMSGWYLTDLPGRIRVA------PQQDDLDSPQQISISNAEARQALPH 580
            C SS W+  ++   S     + PG   +          + + SP    +  +   + L  
Sbjct: 933  CTSSSWSRAQLHGAS-----EEPGHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLLSG 987

Query: 581  SYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSIS--TAQ 638
             Y+WS P+ +LG+K+ + GG+L FT++     +   T    Q +++L+GN++ +    AQ
Sbjct: 988  PYFWSLPSRFLGDKVTSYGGELRFTVTQ--RSQPGSTPLHGQPLVVLQGNNIILEHHVAQ 1045

Query: 639  DEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIF 698
            +     P +  T ++  +E+++       P  R+  +  LA +  +L++ +Y+    A  
Sbjct: 1046 EP---SPGQPSTFIVPFREQAWQRPDGQ-PATREHLLMALAGIDTLLIRASYA-QQPAES 1100

Query: 699  RLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQ 758
            R+S ++++ AV   T    A  VE C CPPGY G SC+ C   + R    ++ G CE C 
Sbjct: 1101 RVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCS 1160

Query: 759  CFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNF 818
            C GH+E+C+  TG C  C+ HT GP C++C PG+YG+  +GT +DCQ C C  +  +   
Sbjct: 1161 CHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQA 1220

Query: 819  SPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQ-------PCQCNDNL 871
            + TC LD      CD C  G++G  CERCA GY+G PS  G  CQ       P  CN + 
Sbjct: 1221 AHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPS-QGQPCQRDSQVPGPIGCNCDP 1279

Query: 872  DFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG-DAVDAKNCQPCRC 920
              S+   CD+ +G C  CK    G  C  C   +F   A +   C PC C
Sbjct: 1280 QGSVSSQCDA-AGQCQ-CKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327



 Score =  252 bits (643), Expect = 5e-66
 Identities = 156/436 (35%), Positives = 215/436 (49%), Gaps = 29/436 (6%)

Query: 500 CKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQ-------DMSGWYLTDLPGRI 552
           C  G F L+      C  CFC G+++ CQS+     +I+       D  G  +T +P + 
Sbjct: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVT-MPAQ- 560

Query: 553 RVAPQQDDLDSPQ-QISISNAE------ARQALPHSYYWSAPAPYLGNKLPAVGGQLTFT 605
              P    L S Q QI  S  E      +R+ L H  +W+ P  +LGNK+ + GG L + 
Sbjct: 561 ---PGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYN 617

Query: 606 ISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGT 665
           + Y+L       E V +  ++L G    +  ++      P   +   +   EE + +H +
Sbjct: 618 VRYELARGM--LEPVQRPDVVLMGAGYRL-LSRGHTPTQPGALNQRQVQFSEEHW-VHES 673

Query: 666 HFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQ 725
             PV+R E + VL +L+ VL+Q  Y+  M ++  LS + +++ V++ T    A +VE C+
Sbjct: 674 GRPVQRAELLQVLQSLEAVLIQTVYNTKMASV-GLSDIAMDTTVTHATSHGRAHSVEECR 732

Query: 726 CPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYC 785
           CP GY+G SCESC     RV G  + G C  C C GHA SCD V G CLNC+ +T GP C
Sbjct: 733 CPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQC 792

Query: 786 DKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCE 845
           +KC  GF+G+  K T+  C+PC CP    S  FS TC LD      CD C  GYTG RCE
Sbjct: 793 NKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCE 852

Query: 846 RCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGY 905
            CA GY G P  PGG C+P   N  +           SG    CK    GR C  CADG 
Sbjct: 853 SCAPGYEGNPIQPGGKCRP--VNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGS 910

Query: 906 FG-DAVDAKNCQPCRC 920
           F     +   C  C C
Sbjct: 911 FHLSTRNPDGCLKCFC 926



 Score =  232 bits (592), Expect = 4e-60
 Identities = 145/445 (32%), Positives = 207/445 (46%), Gaps = 43/445 (9%)

Query: 1148 CRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQ--------TILPLVD 1199
            C  G F L+  +   C  C+CFG T+ C   +   R  + L+ +Q          +P   
Sbjct: 505  CPDGHFYLE--HSAACLPCFCFGITSVCQSTRRF-RDQIRLRFDQPDDFKGVNVTMPAQP 561

Query: 1200 EALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYF 1259
                 ++T+  +         +DL R  L  + F W LPEQF G K+ +YGG L+Y + +
Sbjct: 562  GTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSF-WALPEQFLGNKVDSYGGSLRYNVRY 620

Query: 1260 EAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPR 1319
            E           P V++ G      R++ R       G L + +++ +E+ W +    P 
Sbjct: 621  ELARGMLEPVQRPDVVLMGAG---YRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRP- 676

Query: 1320 VHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEK 1379
                V R + L +L  +  +LI+  Y   M    +S+I+M+        T    A  +E+
Sbjct: 677  ----VQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTH--ATSHGRAHSVEE 730

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNC 1439
            C CP+GYSGLSCE+C   F R+   PGG    P LGTC  C CNGH+S CDP    C NC
Sbjct: 731  CRCPIGYSGLSCESCDAHFTRV---PGG----PYLGTCSGCNCNGHASSCDPVYGHCLNC 783

Query: 1440 QHHTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACP 1498
            QH+T G  C +C  G++G  +K     C+ C CP I +S  FS +C  +      C AC 
Sbjct: 784  QHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACA 843

Query: 1499 RGYEGQYCERCAPGYTGSPGNPGGSCQE-----CECDPYGSLPVPCDPVTGFCTCRPGAT 1553
             GY G+ CE CAPGY G+P  PGG C+        CD  GS+    +     C C+    
Sbjct: 844  PGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEA----CRCKNNVV 899

Query: 1554 GRKC----DGCKHWHAREGWECVFC 1574
            GR C    DG  H   R    C+ C
Sbjct: 900  GRLCNECADGSFHLSTRNPDGCLKC 924



 Score =  117 bits (293), Expect = 2e-25
 Identities = 68/212 (32%), Positives = 97/212 (45%), Gaps = 28/212 (13%)

Query: 835  CPVGYTGPRCERCAEGYFGQPS-VPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGT 893
            CP GY GP C+ C  GY   PS +  G+C+ C C+ + +     +C+  +G+C  C+  T
Sbjct: 1128 CPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSE-----ACEPETGACQGCQHHT 1182

Query: 894  TGRYCELCADGYFGDAVDA--KNCQPCRCN---AGGSFSEVCHSQTG---QCE-CRANVQ 944
             G  CE C  GY+GDA     ++CQ C C    A G  +  C   T     C+ C     
Sbjct: 1183 EGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHS 1242

Query: 945  GQRCDKCKAGTFGLQS----------ARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGK 994
            G+ C++C  G +G  S            G + CNC+  GS S  C+ +GQC C+  V G 
Sbjct: 1243 GRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGL 1302

Query: 995  KCDRCAHGYFNFQEG---GCTACECSHLGNNC 1023
             C  C   +F+       GC  C C  +   C
Sbjct: 1303 TCSHCRPHHFHLSASNPDGCLPCFCMGITQQC 1334



 Score = 93.6 bits (231), Expect = 3e-18
 Identities = 54/144 (37%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 835  CPVGYTGPRCERCAEGYFGQPS-VPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGT 893
            CP GY G  C+ CA GY    S +  G C+ C+CN + D      C   +G+C  C+   
Sbjct: 1532 CPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL-----CHPETGACSQCQHNA 1586

Query: 894  TGRYCELCADGYFGDAV--DAKNCQPCRC---NAGGSFSEVCHSQTG---QC-ECRANVQ 944
             G +CELCA GY+GDA     ++CQPC C   N    FS  C S      +C  C     
Sbjct: 1587 AGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYT 1646

Query: 945  GQRCDKCKAGTFGLQSARG--CVP 966
            GQ C++C  G  G  S +G  C+P
Sbjct: 1647 GQYCEQCGPGYVGNPSVQGGQCLP 1670



 Score = 85.9 bits (211), Expect = 6e-16
 Identities = 59/162 (36%), Positives = 82/162 (50%), Gaps = 13/162 (8%)

Query: 2788 TIELEVRTEAESGLLFYMA-RINHA----DFATVQLRNGLPYFSYDLGSGDTHTMIPTKI 2842
            TIELEVRT   SGLL +    +  A    DF ++ L++G   F Y LGSG+   +    I
Sbjct: 4229 TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPI 4288

Query: 2843 NDGQWHKIKIMRSKQEGILYVDG---ASNRTISPKKADILDVVGMLYVGGLPINYTTRRI 2899
            NDG+WH++  +R  + G + VDG    S R+  P  A  ++  G +Y+GG P +  T   
Sbjct: 4289 NDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVA--VNAKGSVYIGGAP-DVATLTG 4345

Query: 2900 GPVTYSIDGCVRN--LHMAEAPADLEQPTSSFHVGTCFANAQ 2939
            G  +  I GCV+N  LH A   A   QP    H     AN +
Sbjct: 4346 GRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTR 4387



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 65/205 (31%), Positives = 84/205 (40%), Gaps = 36/205 (17%)

Query: 889  CKPGTTGRYCELCADGYFGDAVDAK---NCQPCRCNAGGSFSEVCHSQTGQC-ECRANVQ 944
            C  G +G  CE C D +F           C  C CN   S    C    G C  C+ N +
Sbjct: 733  CPIGYSGLSCESC-DAHFTRVPGGPYLGTCSGCNCNGHASS---CDPVYGHCLNCQHNTE 788

Query: 945  GQRCDKCKAGTFG---LQSARGCVPCNC------NSFGSKSF-DCEESGQC-WCQPGVTG 993
            G +C+KCKAG FG     +A  C PC C        F    F D +    C  C PG TG
Sbjct: 789  GPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTG 848

Query: 994  KKCDRCAHGYFN--FQEGGCTACECSHLGN---NCDPKTG------RCICPPNTIGEKCS 1042
            ++C+ CA GY     Q GG    +C  +      CD +         C C  N +G  C+
Sbjct: 849  RRCESCAPGYEGNPIQPGG----KCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCN 904

Query: 1043 KCAPNTWGHSITT--GCKACNCSTV 1065
            +CA  ++  S     GC  C C  V
Sbjct: 905  ECADGSFHLSTRNPDGCLKCFCMGV 929



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 53/169 (31%), Positives = 80/169 (47%), Gaps = 16/169 (9%)

Query: 2936 ANAQRGTYFDGTGFAKAVGG-FKVGLDLL---VEFEFRTTTTTGVLL------GISSQKM 2985
            A  Q G YF   GF    G  F   L  +   +E E RT+T +G+LL      G + Q  
Sbjct: 4198 APGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGK 4257

Query: 2986 DGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQ 3045
            D + + + D  L+F    G+G    V +  +     DG+WH+VTA +   R  + VDG +
Sbjct: 4258 DFISLGLQDGHLVFRYQLGSGEARLVSEDPIN----DGEWHRVTALREGRRGSIQVDGEE 4313

Query: 3046 -VEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKL 3093
             V  +SP P + + +    V++GG PD     G   S    GC+++L L
Sbjct: 4314 LVSGRSPGP-NVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 45/148 (30%), Positives = 73/148 (49%), Gaps = 17/148 (11%)

Query: 2338 EGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATR-----DLRDFMSVE 2392
            +G + F G  +   SR +   P   T+  + RT ++S LL++           +DF+S+ 
Sbjct: 4209 DGFLAFPGHVF---SRSLPEVPE--TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLG 4263

Query: 2393 LTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATS 2452
            L DGH+   Y LGSG A +VS    NDG+W   T  R  ++ +I +     + EE ++  
Sbjct: 4264 LQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQV-----DGEELVSGR 4318

Query: 2453 SSGNNFGLDLKADDKIYFGGLPTLRNLS 2480
            S G N  ++ K    +Y GG P +  L+
Sbjct: 4319 SPGPNVAVNAKG--SVYIGGAPDVATLT 4344



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 33/139 (23%), Positives = 69/139 (49%), Gaps = 14/139 (10%)

Query: 2367 KFRTFSSSALLMYLATRD--LRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKS 2424
            +F+  +   +L++   +   + DF+S+ +  GH++  Y+LGSG+A + S +    G+W  
Sbjct: 3956 EFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHR 4015

Query: 2425 FTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKAR 2484
             +  R+ K  ++ +     N    +  SS G + GL+L     +Y GG+      S+   
Sbjct: 4016 VSAERLNKDGSLRV-----NGGRPVLRSSPGKSQGLNLHT--LLYLGGVEP----SVPLS 4064

Query: 2485 PEVNLK-KYSGCLKDIEIS 2502
            P  N+   + GC+ ++ ++
Sbjct: 4065 PATNMSAHFRGCVGEVSVN 4083



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 13/142 (9%)

Query: 2786 RLTIELEVRTEAESGLLFYMARIN-----------HADFATVQLRNGLPYFSYDLGSGDT 2834
            +  I++  R ++  G+L Y  +               DF +  L  G P F +D GSG  
Sbjct: 3685 KFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMA 3744

Query: 2835 HTMIPTKINDGQWHKIKIMRSKQEGILYV-DGASNRTISPKKADILDVVGMLYVGGLPIN 2893
                PT +  G +H + ++RS  +G L V D A     S  K   LD+   LY+GG P +
Sbjct: 3745 TIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYP-D 3803

Query: 2894 YTTRRIGPVTYSIDGCVRNLHM 2915
            Y       ++    GCVR L +
Sbjct: 3804 YGAIPKAGLSSGFIGCVRELRI 3825



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 17/119 (14%)

Query: 2170 IVVNVKTAVADNLLFYLG-----SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTI 2224
            I + V+T+ A  LL + G     + +  DF+++ ++ G + F + +GSG  R+   D  I
Sbjct: 4230 IELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSED-PI 4288

Query: 2225 DDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGG 2283
            +D  W+R+ A R GR G+I V   DG +         S   PG  +  V+A   +++GG
Sbjct: 4289 NDGEWHRVTALREGRRGSIQV---DGEELV-------SGRSPGPNVA-VNAKGSVYIGG 4336



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 4/159 (2%)

Query: 2781 TKVKNRLTIELEVRTEAESGLLFYMARINHA--DFATVQLRNGLPYFSYDLGSGDTHTMI 2838
            T   + L +++E +  A  G+L +    +    DF ++ +  G   F Y+LGSG      
Sbjct: 3945 TNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRS 4004

Query: 2839 PTKINDGQWHKIKIMRSKQEGILYVDGASN-RTISPKKADILDVVGMLYVGGLPINYTTR 2897
               +  G+WH++   R  ++G L V+G       SP K+  L++  +LY+GG+  +    
Sbjct: 4005 AEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLS 4064

Query: 2898 RIGPVTYSIDGCVRNLHMAEAPADLEQP-TSSFHVGTCF 2935
                ++    GCV  + +     DL      S  +G C+
Sbjct: 4065 PATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCY 4103



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 11/150 (7%)

Query: 2961 DLLVEFEFRTTTTTGVLL---GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVP 3017
            +L ++ EF+     GVLL   G S    D + + M+   L F  + G+G   AV  +  P
Sbjct: 3950 ELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSG--LAVLRSAEP 4007

Query: 3018 GHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFG 3077
              L  G+WH+V+A ++     L V+G +   +S    S   + +  +++GG    +    
Sbjct: 4008 --LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSP 4065

Query: 3078 LTT-SIPFRGCIRSLKLTKGTGKPLEVNFA 3106
             T  S  FRGC+  + +    GK L++ ++
Sbjct: 4066 ATNMSAHFRGCVGEVSV---NGKRLDLTYS 4092



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 41/151 (27%), Positives = 68/151 (45%), Gaps = 26/151 (17%)

Query: 2364 VMFKFRTFSSSALLMY------------LATRDLRDFMSVELTDGHIKVSYDLGSGMASV 2411
            +   FR  S+  +L+Y            LA R   DF+S  L  G  +  +D GSGMA++
Sbjct: 3688 IKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ-PDFISFGLVGGRPEFRFDAGSGMATI 3746

Query: 2412 VSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFG 2471
                    G + + TL R   Q ++ + D+       +  +S G   GLDL  ++++Y G
Sbjct: 3747 RHPTPLALGHFHTVTLLRSLTQGSLIVGDL-----APVNGTSQGKFQGLDL--NEELYLG 3799

Query: 2472 GLPTLRNLSMKARPEVNLKK-YSGCLKDIEI 2501
            G P        A P+  L   + GC++++ I
Sbjct: 3800 GYP-----DYGAIPKAGLSSGFIGCVRELRI 3825



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 37/156 (23%), Positives = 76/156 (48%), Gaps = 16/156 (10%)

Query: 2172 VNVKTAVADNLLFYLG--SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYW 2229
            V  K    D +L + G  S    DF+++ M  G + F +++GSG+  +   +  +    W
Sbjct: 3955 VEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAE-PLALGRW 4013

Query: 2230 YRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLK 2289
            +R+ A R  ++G++ V   +G +  +        S PG +   ++ + +L++GG+   + 
Sbjct: 4014 HRVSAERLNKDGSLRV---NGGRPVL-------RSSPGKS-QGLNLHTLLYLGGVEPSVP 4062

Query: 2290 KADAVRVIT-FTGCMGETYFDNKPIGL-WNFREKEG 2323
             + A  +   F GC+GE   + K + L ++F   +G
Sbjct: 4063 LSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQG 4098



 Score = 41.6 bits (96), Expect = 0.012
 Identities = 31/140 (22%), Positives = 48/140 (34%), Gaps = 29/140 (20%)

Query: 286  MCICYGH------ARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKT 339
            +C CYG       A  C LD   + +   C     G  C++C PG++  P +       +
Sbjct: 1208 LCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDS 1267

Query: 340  ECE---ACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDG 396
            +      CNC  +                 ++  +    G C  C     G+ C  C   
Sbjct: 1268 QVPGPIGCNCDPQG----------------SVSSQCDAAGQC-QCKAQVEGLTCSHCRPH 1310

Query: 397  FFRPKGVSPNYPRPCQPCHC 416
             F    +S + P  C PC C
Sbjct: 1311 HFH---LSASNPDGCLPCFC 1327



 Score = 39.7 bits (91), Expect = 0.047
 Identities = 31/121 (25%), Positives = 36/121 (29%), Gaps = 23/121 (19%)

Query: 296 CPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYY 355
           C LD     +   C     G  C+ C PG+   P + G        E   C         
Sbjct: 829 CFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRC--------- 879

Query: 356 DENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCH 415
           DE           RG     G    C  N  G  C  C DG F    +S   P  C  C 
Sbjct: 880 DE-----------RGSMGTSGEACRCKNNVVGRLCNECADGSFH---LSTRNPDGCLKCF 925

Query: 416 C 416
           C
Sbjct: 926 C 926



 Score = 35.4 bits (80), Expect = 0.89
 Identities = 32/144 (22%), Positives = 63/144 (43%), Gaps = 20/144 (13%)

Query: 2964 VEFEFRTTTTTGVLL------------GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAV 3011
            ++  FR  +  G+LL             +++++ D +   ++  +  F  D G+G  T  
Sbjct: 3688 IKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIR 3747

Query: 3012 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3071
            +    P  L  G +H VT  +   +  L V        +        D N+ +++GG+PD
Sbjct: 3748 H----PTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPD 3803

Query: 3072 --DLKQFGLTTSIPFRGCIRSLKL 3093
               + + GL++   F GC+R L++
Sbjct: 3804 YGAIPKAGLSSG--FIGCVRELRI 3825



 Score = 33.9 bits (76), Expect = 2.6
 Identities = 19/59 (32%), Positives = 22/59 (37%), Gaps = 11/59 (18%)

Query: 723  VCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTG 781
            VC CP G+TGS CE     H           C P  C   A   +   G    C+ H G
Sbjct: 3868 VCVCPAGFTGSRCEHSQALH-----------CHPEACGPDATCVNRPDGRGYTCRCHLG 3915



 Score = 33.9 bits (76), Expect = 2.6
 Identities = 35/123 (28%), Positives = 47/123 (38%), Gaps = 21/123 (17%)

Query: 937  CECRANVQGQRCDKCKA--GTFGLQSARGCVPCN---CNSFGSKSFDCEESGQCWCQPGV 991
            C    +V G+R D   +  G+ G+       PC    C    +     E   QC C+ G 
Sbjct: 4076 CVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGF 4135

Query: 992  TGKKCDRCAHGYFNFQEGGCTACE-CSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWG 1050
             G   D C H     +E  C   E C H G  C     RC+C P   G +C + +    G
Sbjct: 4136 KG---DLCEH-----EENPCQLREPCLH-GGTCQGT--RCLCLPGFSGPRCQQGS----G 4180

Query: 1051 HSI 1053
            H I
Sbjct: 4181 HGI 4183



 Score = 32.7 bits (73), Expect = 5.8
 Identities = 24/89 (26%), Positives = 34/89 (38%), Gaps = 20/89 (22%)

Query: 1483 SCVAEGLDDYRCTACPRGYEGQYCERCA-PGYTGSPGNPGGSCQECECDPYGSLPVPCDP 1541
            +C+  G  +++C  C  G++G  CE    P     P   GG+CQ   C            
Sbjct: 4118 TCMPAGEYEFQCL-CRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRC------------ 4164

Query: 1542 VTGFCTCRPGATGRKC-DGCKHWHAREGW 1569
                  C PG +G +C  G  H  A   W
Sbjct: 4165 -----LCLPGFSGPRCQQGSGHGIAESDW 4188


>gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]
          Length = 1111

 Score =  312 bits (799), Expect = 4e-84
 Identities = 218/643 (33%), Positives = 296/643 (46%), Gaps = 100/643 (15%)

Query: 342 EACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGV-CINCTQNTAGINCETCTDGFFRP 400
           E C+C+GK+ +C +D  + R+           G G  C+NC  NT GI+CE C +GF+R 
Sbjct: 26  EVCDCNGKSRQCIFDRELHRQT----------GNGFRCLNCNDNTDGIHCEKCKNGFYRH 75

Query: 401 KGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGY 460
           +         C PC+C+  GSL+  C             G C CK G  G  CDRC  G+
Sbjct: 76  RERDR-----CLPCNCNSKGSLSARCDNS----------GRCSCKPGVTGARCDRCLPGF 120

Query: 461 TGYPDC----------KACNCSGLGSKNEDPC-FGPCICKENVEGGDCSRCKSGFFNLQE 509
               D             C+C   G     PC  G C+CK  V G  C RC+SG++NL  
Sbjct: 121 HMLTDAGCTQDQRLLDSKCDCDPAGIAG--PCDAGRCVCKPAVTGERCDRCRSGYYNLDG 178

Query: 510 DNWKGCDECFCSGVSNRCQSSY-WTYGKI-----QDMSGWYLTDLPGRIRVAPQQDDLDS 563
            N +GC +CFC G S  C+SS  ++  KI     QD+ GW      G    +P +     
Sbjct: 179 GNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRNG----SPAKLQWSQ 234

Query: 564 PQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQL 623
             Q   S+A+    +    Y+ APA +LGN+  + G  L+F    D          V   
Sbjct: 235 RHQDVFSSAQRLDPV----YFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDV--- 287

Query: 624 MIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHG----------THFPVRRKE 673
             ILEG  L I+       L P  +     L K  +F ++           ++F  RR  
Sbjct: 288 --ILEGAGLRITAP-----LMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRR-- 338

Query: 674 FMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGS 733
              +L NL  + ++ TY  G  +   + +V L SA   P  G+ A  VE C CP GY G 
Sbjct: 339 ---LLRNLTALRIRATY--GEYSTGYIDNVTLISA--RPVSGAPAPWVEQCICPVGYKGQ 391

Query: 734 SCESCWPRHRRVNGTIFG-GICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGF 792
            C+ C   ++R +  +   G C PC C G   +CD  TG+C +  D      C  C  GF
Sbjct: 392 FCQDCASGYKRDSARLGPFGTCIPCNCQGGG-ACDPDTGDCYS-GDENPDIECADCPIGF 449

Query: 793 YGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYF 852
           Y +P    S  C+PC C      N FS +  +  +  ++C+ CP G TG RCE CA+GYF
Sbjct: 450 YNDPHDPRS--CKPCPC-----HNGFSCSV-MPETEEVVCNNCPPGVTGARCELCADGYF 501

Query: 853 GQPSVPGGS---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDA 909
           G P    G    CQPCQCN+N+D S  G+CD L+G CL C   T G YC+ C  GYFGD 
Sbjct: 502 GDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDP 561

Query: 910 V---DAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCD 949
           +    A  C+ C CN  GS    C S  G C C+    G  C+
Sbjct: 562 LAPNPADKCRACNCNPMGSEPVGCRSD-GTCVCKPGFGGPNCE 603



 Score =  243 bits (620), Expect = 2e-63
 Identities = 278/1166 (23%), Positives = 454/1166 (38%), Gaps = 202/1166 (17%)

Query: 1014 CECSHLGNNC------DPKTG---RCI-CPPNTIGEKCSKCAPNTWGHSITTGCKACNCS 1063
            C+C+     C        +TG   RC+ C  NT G  C KC    + H     C  CNC+
Sbjct: 28   CDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCN 87

Query: 1064 TVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSET- 1122
            + GSL  +C+ N+G+C+C P  +GA+C  C  G            F   TDA     +  
Sbjct: 88   SKGSLSARCD-NSGRCSCKPGVTGARCDRCLPG------------FHMLTDAGCTQDQRL 134

Query: 1123 --KKCSCSD-------QTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTT 1173
               KC C           G+C CK  V G  CDRCR G + LD  NP GC+ C+C+G + 
Sbjct: 135  LDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSA 194

Query: 1174 QCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPF 1233
             C  +       +T    Q +     +  +     G   +      H D+      L+P 
Sbjct: 195  SCRSSAEYSVHKITSTFHQDV-----DGWKAVQRNGSPAKLQWSQRHQDVFSSAQRLDPV 249

Query: 1234 YWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAA 1293
            Y+  P +F G + ++YG  L     F+ R + G    +   +I  G        +  +  
Sbjct: 250  YFVAPAKFLGNQQVSYGQSLS----FDYRVDRGGRHPSAHDVILEGAGLRITAPLMPLGK 305

Query: 1294 PLIGQLTR-HEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQS 1352
             L   LT+ +   + E     +         ++  ++  +L ++  + I+ATYG +    
Sbjct: 306  TLPCGLTKTYTFRLNEHPSNNWSPQ------LSYFEYRRLLRNLTALRIRATYGEYST-G 358

Query: 1353 RISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGP 1412
             I  +++  A    G     PA  +E+C CP+GY G  C+ C  G+ R  ++ G      
Sbjct: 359  YIDNVTLISARPVSGA----PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLG------ 408

Query: 1413 TLGTCVPCQCNGHSSLCDPETS-------------------------------------- 1434
              GTC+PC C G  + CDP+T                                       
Sbjct: 409  PFGTCIPCNCQGGGA-CDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNG 467

Query: 1435 ------------ICQNCQHHTAGDFCERCALGYYGIV---KGLPNDCQQCACPLISSSNN 1479
                        +C NC     G  CE CA GY+G      G    CQ C C     +NN
Sbjct: 468  FSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQC-----NNN 522

Query: 1480 FSPSCVAEGLDDY---RCTACPRGYEGQYCERCAPGYTGSP--GNPGGSCQECECDPYGS 1534
              PS  A G  D    RC  C     G YC++C  GY G P   NP   C+ C C+P GS
Sbjct: 523  VDPS--ASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGS 580

Query: 1535 LPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDEC---TGLLLGDLARLEQ 1591
             PV C    G C C+PG  G  C+          + C  C ++        +  L R+E 
Sbjct: 581  EPVGCRS-DGTCVCKPGFGGPNCE-------HGAFSCPACYNQVKIQMDQFMQQLQRMEA 632

Query: 1592 MVMSINLTGPLPAPYKMLYG-LENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNEL 1650
            ++      G    P   L G ++   Q L+ +L       R  Q++EG   +L  ++ ++
Sbjct: 633  LISKAQ-GGDGVVPDTELEGRMQQAEQALQDIL-------RDAQISEGASRSLGLQLAKV 684

Query: 1651 LTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDA-EAVNEKAIKLNE---TLGTR 1706
             ++        +    D + T  R ++LG   +   RD    + +  + L E   +LG  
Sbjct: 685  RSQENSY----QSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGNT 740

Query: 1707 DEAFERNLEGLQ--KEIDQMIKELRRKNLET---QKEIAEDELVAAEALLKKVKKLFGES 1761
            +     +  G    K + Q    L   ++E+    +++  +    ++  L  V+K   E 
Sbjct: 741  NIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHEG 800

Query: 1762 RGENE-----EMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEK 1816
             G         + + L EKL   K+    A  L REAT    EA+R +  + + + ++  
Sbjct: 801  VGSGSGSPDGAVVQGLVEKLEKTKSL---AQQLTREATQAEIEADRSYQHSLRLLDSV-S 856

Query: 1817 KKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDD 1876
            + + V     Q+E    E   I  +A+ L+  +   +D  +  Q  L    EE    + +
Sbjct: 857  RLQGVSDQSFQVE----EAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQN 912

Query: 1877 -LSQEIKDRKLAEKVSQAESHA--------AQLNDSSAVLDGILD---EAKNISFNATAA 1924
              S   K  +L  + + A+S A        A   +  ++L  + +   +  N    A  A
Sbjct: 913  GKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEA 972

Query: 1925 FKAYSNIKDYIDEAEKVAKEAK----DLAHEATKLATGPRGLLKEDAKGCLQKSFRILN- 1979
             K  S I   + +A    ++A+      A +A +   G    L+  ++  +++    LN 
Sbjct: 973  MKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSE--IEQEIGSLNL 1030

Query: 1980 EAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKD 2039
            EA   A+     E  L  LK+ +   +   G+L R   +    + A+        Q V  
Sbjct: 1031 EANVTADGALAMEKGLASLKSEMREVE---GELERKELEFDTNMDAV--------QMVIT 1079

Query: 2040 KARQANDTAKDVLAQITELHQNLDGL 2065
            +A++ +  AK+    I +    LDGL
Sbjct: 1080 EAQKVDTRAKNAGVTIQDTLNTLDGL 1105



 Score =  127 bits (319), Expect = 2e-28
 Identities = 82/238 (34%), Positives = 103/238 (43%), Gaps = 30/238 (12%)

Query: 888  ICKPGTTGRYCELCADGYFGDAVDAK---NCQPCRCNAGGSFSEVCHSQTGQCECRANVQ 944
            IC  G  G++C+ CA GY  D+        C PC C  GG+    C   TG C       
Sbjct: 383  ICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQGGGA----CDPDTGDCYSGDENP 438

Query: 945  GQRCDKCKAGTFG-LQSARGCVPCNC-NSFGSKSFDCEESGQCW-CQPGVTGKKCDRCAH 1001
               C  C  G +      R C PC C N F        E   C  C PGVTG +C+ CA 
Sbjct: 439  DIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCAD 498

Query: 1002 GYFN--FQEGG----CTACECSH-----LGNNCDPKTGRCI-CPPNTIGEKCSKCAPNTW 1049
            GYF   F E G    C  C+C++        NCD  TGRC+ C  NT G  C +C    +
Sbjct: 499  GYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYF 558

Query: 1050 GHSITTG----CKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRC 1103
            G  +       C+ACNC+ +GS    C  + G C C P F G     C  G ++ P C
Sbjct: 559  GDPLAPNPADKCRACNCNPMGSEPVGCR-SDGTCVCKPGFGG---PNCEHGAFSCPAC 612



 Score =  120 bits (300), Expect = 3e-26
 Identities = 64/182 (35%), Positives = 80/182 (43%), Gaps = 17/182 (9%)

Query: 898  CELCADGYFGDAVDAKNCQPCRCNAGGS---FSEVCHSQTGQ----CECRANVQGQRCDK 950
            C LC       A      + C CN       F    H QTG       C  N  G  C+K
Sbjct: 8    CCLCFSLLLPAARATSRREVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEK 67

Query: 951  CKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGG 1010
            CK G +  +    C+PCNCNS GS S  C+ SG+C C+PGVTG +CDRC  G+    + G
Sbjct: 68   CKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAG 127

Query: 1011 CT--------ACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWG--HSITTGCKAC 1060
            CT         C+C   G       GRC+C P   GE+C +C    +        GC  C
Sbjct: 128  CTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQC 187

Query: 1061 NC 1062
             C
Sbjct: 188  FC 189



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 70/243 (28%), Positives = 87/243 (35%), Gaps = 60/243 (24%)

Query: 300 PATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHG------KAEEC 353
           PA    +C C     G  C  C  G+ +   R G F T   C  CNC G         +C
Sbjct: 375 PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGT---CIPCNCQGGGACDPDTGDC 431

Query: 354 YY-DEN-------------------------VARRNLSLNIRGKYIGGGVCINCTQNTAG 387
           Y  DEN                               S ++  +     VC NC     G
Sbjct: 432 YSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPE-TEEVVCNNCPPGVTG 490

Query: 388 INCETCTDGFFRPKGVSPNYPRPCQPCHC----DPIGSLNEVCVKDEKHARRGLAPGSC- 442
             CE C DG+F          RPCQPC C    DP  S N  C +           G C 
Sbjct: 491 ARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGN--CDR---------LTGRCL 539

Query: 443 HCKTGFGGVSCDRCARGYTGYP-------DCKACNCSGLGSKNED-PCFGPCICKENVEG 494
            C     G+ CD+C  GY G P        C+ACNC+ +GS+       G C+CK    G
Sbjct: 540 KCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGG 599

Query: 495 GDC 497
            +C
Sbjct: 600 PNC 602



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 61/203 (30%), Positives = 77/203 (37%), Gaps = 26/203 (12%)

Query: 984  QCWCQPGVTGKKCDRCAHGYFNFQE-----GGCTACECSHLGNNCDPKTGRCICPPNTIG 1038
            QC C  G  G+ C  CA GY          G C  C C   G  CDP TG C        
Sbjct: 381  QCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQG-GGACDPDTGDCYSGDENPD 439

Query: 1039 EKCSKCAPNTWGHSITT-GCKACNCSTVGSLDFQCNVNTGQCN-CHPKFSGAKCTECSRG 1096
             +C+ C    +        CK C C    S           CN C P  +GA+C  C+ G
Sbjct: 440  IECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADG 499

Query: 1097 HWNYP--------RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT-CKVNVEGIHCDR 1147
            ++  P         C  C C             +   +C   TG+C  C  N  GI+CD+
Sbjct: 500  YFGDPFGEHGPVRPCQPCQC-------NNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQ 552

Query: 1148 CRPGKFGLD-AKNPLG-CSSCYC 1168
            C+ G FG   A NP   C +C C
Sbjct: 553  CKAGYFGDPLAPNPADKCRACNC 575



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 57/169 (33%), Positives = 74/169 (43%), Gaps = 25/169 (14%)

Query: 816 NNFSPTCHLDRSL------GLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCND 869
           N  S  C  DR L      G  C  C     G  CE+C  G++         C PC CN 
Sbjct: 31  NGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRE--RDRCLPCNCNS 88

Query: 870 NLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQP-------CRCNA 922
               S+   CD+ SG C  CKPG TG  C+ C  G F    DA   Q        C C+ 
Sbjct: 89  K--GSLSARCDN-SGRCS-CKPGVTGARCDRCLPG-FHMLTDAGCTQDQRLLDSKCDCDP 143

Query: 923 GGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQ--SARGCVPCNC 969
            G  +  C +  G+C C+  V G+RCD+C++G + L   +  GC  C C
Sbjct: 144 AG-IAGPCDA--GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 53/184 (28%), Positives = 76/184 (41%), Gaps = 34/184 (18%)

Query: 287 CICYGHARACPLDPATNKSRCE-CEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACN 345
           C C+ +  +C + P T +  C  C     G  C+ C  G+   P+  G       C+ C 
Sbjct: 462 CPCH-NGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPF--GEHGPVRPCQPCQ 518

Query: 346 CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSP 405
           C+   +      N  R              G C+ C  NTAGI C+ C  G+F    ++P
Sbjct: 519 CNNNVDPSA-SGNCDRLT------------GRCLKCIHNTAGIYCDQCKAGYFGDP-LAP 564

Query: 406 NYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD 465
           N    C+ C+C+P+GS    C  D          G+C CK GFGG +C+       G   
Sbjct: 565 NPADKCRACNCNPMGSEPVGCRSD----------GTCVCKPGFGGPNCEH------GAFS 608

Query: 466 CKAC 469
           C AC
Sbjct: 609 CPAC 612



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/117 (26%), Positives = 41/117 (35%), Gaps = 28/117 (23%)

Query: 303 NKSRCECEHNTCGDSCDQCCPGFHQKPWRAGT---FLTKTECEACNCHGKAEECYYDENV 359
           N  RC C+    G  CD+C PGFH       T    L  ++C+ C+  G A  C      
Sbjct: 98  NSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCD-CDPAGIAGPC------ 150

Query: 360 ARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHC 416
                           G C+ C     G  C+ C  G++   G     P  C  C C
Sbjct: 151 --------------DAGRCV-CKPAVTGERCDRCRSGYYNLDG---GNPEGCTQCFC 189



 Score = 35.0 bits (79), Expect = 1.2
 Identities = 20/80 (25%), Positives = 31/80 (38%), Gaps = 19/80 (23%)

Query: 1106 CDCFLPGTDATTCDSETKKCSCSDQTGQC-----------------TCKVNVEGIHCDRC 1148
            C CF     A    S  + C C+ ++ QC                  C  N +GIHC++C
Sbjct: 9    CLCFSLLLPAARATSRREVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKC 68

Query: 1149 RPGKFGLDAKNPLGCSSCYC 1168
            + G +    ++   C  C C
Sbjct: 69   KNGFYRHRERD--RCLPCNC 86


>gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]
          Length = 1193

 Score =  312 bits (799), Expect = 4e-84
 Identities = 218/643 (33%), Positives = 296/643 (46%), Gaps = 100/643 (15%)

Query: 342 EACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGV-CINCTQNTAGINCETCTDGFFRP 400
           E C+C+GK+ +C +D  + R+           G G  C+NC  NT GI+CE C +GF+R 
Sbjct: 26  EVCDCNGKSRQCIFDRELHRQT----------GNGFRCLNCNDNTDGIHCEKCKNGFYRH 75

Query: 401 KGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGY 460
           +         C PC+C+  GSL+  C             G C CK G  G  CDRC  G+
Sbjct: 76  RERDR-----CLPCNCNSKGSLSARCDNS----------GRCSCKPGVTGARCDRCLPGF 120

Query: 461 TGYPDC----------KACNCSGLGSKNEDPC-FGPCICKENVEGGDCSRCKSGFFNLQE 509
               D             C+C   G     PC  G C+CK  V G  C RC+SG++NL  
Sbjct: 121 HMLTDAGCTQDQRLLDSKCDCDPAGIAG--PCDAGRCVCKPAVTGERCDRCRSGYYNLDG 178

Query: 510 DNWKGCDECFCSGVSNRCQSSY-WTYGKI-----QDMSGWYLTDLPGRIRVAPQQDDLDS 563
            N +GC +CFC G S  C+SS  ++  KI     QD+ GW      G    +P +     
Sbjct: 179 GNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRNG----SPAKLQWSQ 234

Query: 564 PQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQL 623
             Q   S+A+    +    Y+ APA +LGN+  + G  L+F    D          V   
Sbjct: 235 RHQDVFSSAQRLDPV----YFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDV--- 287

Query: 624 MIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHG----------THFPVRRKE 673
             ILEG  L I+       L P  +     L K  +F ++           ++F  RR  
Sbjct: 288 --ILEGAGLRITAP-----LMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRR-- 338

Query: 674 FMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGS 733
              +L NL  + ++ TY  G  +   + +V L SA   P  G+ A  VE C CP GY G 
Sbjct: 339 ---LLRNLTALRIRATY--GEYSTGYIDNVTLISA--RPVSGAPAPWVEQCICPVGYKGQ 391

Query: 734 SCESCWPRHRRVNGTIFG-GICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGF 792
            C+ C   ++R +  +   G C PC C G   +CD  TG+C +  D      C  C  GF
Sbjct: 392 FCQDCASGYKRDSARLGPFGTCIPCNCQGGG-ACDPDTGDCYS-GDENPDIECADCPIGF 449

Query: 793 YGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYF 852
           Y +P    S  C+PC C      N FS +  +  +  ++C+ CP G TG RCE CA+GYF
Sbjct: 450 YNDPHDPRS--CKPCPC-----HNGFSCSV-MPETEEVVCNNCPPGVTGARCELCADGYF 501

Query: 853 GQPSVPGGS---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDA 909
           G P    G    CQPCQCN+N+D S  G+CD L+G CL C   T G YC+ C  GYFGD 
Sbjct: 502 GDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDP 561

Query: 910 V---DAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCD 949
           +    A  C+ C CN  GS    C S  G C C+    G  C+
Sbjct: 562 LAPNPADKCRACNCNPMGSEPVGCRSD-GTCVCKPGFGGPNCE 603



 Score =  246 bits (627), Expect = 3e-64
 Identities = 291/1235 (23%), Positives = 483/1235 (39%), Gaps = 207/1235 (16%)

Query: 1014 CECSHLGNNC------DPKTG---RCI-CPPNTIGEKCSKCAPNTWGHSITTGCKACNCS 1063
            C+C+     C        +TG   RC+ C  NT G  C KC    + H     C  CNC+
Sbjct: 28   CDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCN 87

Query: 1064 TVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSET- 1122
            + GSL  +C+ N+G+C+C P  +GA+C  C  G            F   TDA     +  
Sbjct: 88   SKGSLSARCD-NSGRCSCKPGVTGARCDRCLPG------------FHMLTDAGCTQDQRL 134

Query: 1123 --KKCSCSD-------QTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTT 1173
               KC C           G+C CK  V G  CDRCR G + LD  NP GC+ C+C+G + 
Sbjct: 135  LDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSA 194

Query: 1174 QCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPF 1233
             C  +       +T    Q +     +  +     G   +      H D+      L+P 
Sbjct: 195  SCRSSAEYSVHKITSTFHQDV-----DGWKAVQRNGSPAKLQWSQRHQDVFSSAQRLDPV 249

Query: 1234 YWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAA 1293
            Y+  P +F G + ++YG  L     F+ R + G    +   +I  G        +  +  
Sbjct: 250  YFVAPAKFLGNQQVSYGQSLS----FDYRVDRGGRHPSAHDVILEGAGLRITAPLMPLGK 305

Query: 1294 PLIGQLTR-HEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQS 1352
             L   LT+ +   + E     +         ++  ++  +L ++  + I+ATYG +    
Sbjct: 306  TLPCGLTKTYTFRLNEHPSNNWSPQ------LSYFEYRRLLRNLTALRIRATYGEYST-G 358

Query: 1353 RISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGP 1412
             I  +++  A    G     PA  +E+C CP+GY G  C+ C  G+ R  ++ G      
Sbjct: 359  YIDNVTLISARPVSGA----PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLG------ 408

Query: 1413 TLGTCVPCQCNGHSSLCDPETS-------------------------------------- 1434
              GTC+PC C G  + CDP+T                                       
Sbjct: 409  PFGTCIPCNCQGGGA-CDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNG 467

Query: 1435 ------------ICQNCQHHTAGDFCERCALGYYGIV---KGLPNDCQQCACPLISSSNN 1479
                        +C NC     G  CE CA GY+G      G    CQ C C     +NN
Sbjct: 468  FSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQC-----NNN 522

Query: 1480 FSPSCVAEGLDDY---RCTACPRGYEGQYCERCAPGYTGSP--GNPGGSCQECECDPYGS 1534
              PS  A G  D    RC  C     G YC++C  GY G P   NP   C+ C C+P GS
Sbjct: 523  VDPS--ASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGS 580

Query: 1535 LPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDEC---TGLLLGDLARLEQ 1591
             PV C    G C C+PG  G  C+          + C  C ++        +  L R+E 
Sbjct: 581  EPVGCRS-DGTCVCKPGFGGPNCE-------HGAFSCPACYNQVKIQMDQFMQQLQRMEA 632

Query: 1592 MVMSINLTGPLPAPYKMLYG-LENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNEL 1650
            ++      G    P   L G ++   Q L+ +L       R  Q++EG   +L  ++ ++
Sbjct: 633  LISKAQ-GGDGVVPDTELEGRMQQAEQALQDIL-------RDAQISEGASRSLGLQLAKV 684

Query: 1651 LTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDA-EAVNEKAIKLNE---TLGTR 1706
             ++        +    D + T  R ++LG   +   RD    + +  + L E   +LG  
Sbjct: 685  RSQENSY----QSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGNT 740

Query: 1707 DEAFERNLEGLQ--KEIDQMIKELRRKNLET---QKEIAEDELVAAEALLKKVKKLFGES 1761
            +     +  G    K + Q    L   ++E+    +++  +    ++  L  V+K   E 
Sbjct: 741  NIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHEG 800

Query: 1762 RGENE-----EMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEK 1816
             G         + + L EKL   K+    A  L REAT    EA+R +  + + + ++  
Sbjct: 801  VGSGSGSPDGAVVQGLVEKLEKTKSL---AQQLTREATQAEIEADRSYQHSLRLLDSV-S 856

Query: 1817 KKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDD 1876
            + + V     Q+E    E   I  +A+ L+  +   +D  +  Q  L    EE    + +
Sbjct: 857  RLQGVSDQSFQVE----EAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQN 912

Query: 1877 -LSQEIKDRKLAEKVSQAESHA--------AQLNDSSAVLDGILD---EAKNISFNATAA 1924
              S   K  +L  + + A+S A        A   +  ++L  + +   +  N    A  A
Sbjct: 913  GKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEA 972

Query: 1925 FKAYSNIKDYIDEAEKVAKEAK----DLAHEATKLATGPRGLLKEDAKGCLQKSFRILN- 1979
             K  S I   + +A    ++A+      A +A +   G    L+  ++  +++    LN 
Sbjct: 973  MKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSE--IEQEIGSLNL 1030

Query: 1980 EAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKD 2039
            EA   A+     E  L  LK+ +   +   G+L R   +    + A+      + Q V  
Sbjct: 1031 EANVTADGALAMEKGLASLKSEMREVE---GELERKELEFDTNMDAV-QMVITEAQKVDT 1086

Query: 2040 KARQANDTAKDVLAQITELHQNLD--------GLKKNYNKLADSVAKTNAVVKDPSKNKI 2091
            +A+ A  T +D L  +  L   +D        GL     KL+ +  + N+ ++ P  +++
Sbjct: 1087 RAKNAGVTIQDTLNTLDGLLHLMDQPLSVDEEGLVLLEQKLSRAKTQINSQLR-PMMSEL 1145

Query: 2092 IADA---DATVKNLEQEADRLIDKLKPIKELEDNL 2123
               A      +  LE   D ++  +K ++ + DNL
Sbjct: 1146 EERARQQRGHLHLLETSIDGILADVKNLENIRDNL 1180



 Score =  127 bits (319), Expect = 2e-28
 Identities = 82/238 (34%), Positives = 103/238 (43%), Gaps = 30/238 (12%)

Query: 888  ICKPGTTGRYCELCADGYFGDAVDAK---NCQPCRCNAGGSFSEVCHSQTGQCECRANVQ 944
            IC  G  G++C+ CA GY  D+        C PC C  GG+    C   TG C       
Sbjct: 383  ICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQGGGA----CDPDTGDCYSGDENP 438

Query: 945  GQRCDKCKAGTFG-LQSARGCVPCNC-NSFGSKSFDCEESGQCW-CQPGVTGKKCDRCAH 1001
               C  C  G +      R C PC C N F        E   C  C PGVTG +C+ CA 
Sbjct: 439  DIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCAD 498

Query: 1002 GYFN--FQEGG----CTACECSH-----LGNNCDPKTGRCI-CPPNTIGEKCSKCAPNTW 1049
            GYF   F E G    C  C+C++        NCD  TGRC+ C  NT G  C +C    +
Sbjct: 499  GYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYF 558

Query: 1050 GHSITTG----CKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRC 1103
            G  +       C+ACNC+ +GS    C  + G C C P F G     C  G ++ P C
Sbjct: 559  GDPLAPNPADKCRACNCNPMGSEPVGCR-SDGTCVCKPGFGG---PNCEHGAFSCPAC 612



 Score =  120 bits (300), Expect = 3e-26
 Identities = 64/182 (35%), Positives = 80/182 (43%), Gaps = 17/182 (9%)

Query: 898  CELCADGYFGDAVDAKNCQPCRCNAGGS---FSEVCHSQTGQ----CECRANVQGQRCDK 950
            C LC       A      + C CN       F    H QTG       C  N  G  C+K
Sbjct: 8    CCLCFSLLLPAARATSRREVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEK 67

Query: 951  CKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGG 1010
            CK G +  +    C+PCNCNS GS S  C+ SG+C C+PGVTG +CDRC  G+    + G
Sbjct: 68   CKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAG 127

Query: 1011 CT--------ACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWG--HSITTGCKAC 1060
            CT         C+C   G       GRC+C P   GE+C +C    +        GC  C
Sbjct: 128  CTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQC 187

Query: 1061 NC 1062
             C
Sbjct: 188  FC 189



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 70/243 (28%), Positives = 87/243 (35%), Gaps = 60/243 (24%)

Query: 300 PATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHG------KAEEC 353
           PA    +C C     G  C  C  G+ +   R G F T   C  CNC G         +C
Sbjct: 375 PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGT---CIPCNCQGGGACDPDTGDC 431

Query: 354 YY-DEN-------------------------VARRNLSLNIRGKYIGGGVCINCTQNTAG 387
           Y  DEN                               S ++  +     VC NC     G
Sbjct: 432 YSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPE-TEEVVCNNCPPGVTG 490

Query: 388 INCETCTDGFFRPKGVSPNYPRPCQPCHC----DPIGSLNEVCVKDEKHARRGLAPGSC- 442
             CE C DG+F          RPCQPC C    DP  S N  C +           G C 
Sbjct: 491 ARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGN--CDR---------LTGRCL 539

Query: 443 HCKTGFGGVSCDRCARGYTGYP-------DCKACNCSGLGSKNED-PCFGPCICKENVEG 494
            C     G+ CD+C  GY G P        C+ACNC+ +GS+       G C+CK    G
Sbjct: 540 KCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGG 599

Query: 495 GDC 497
            +C
Sbjct: 600 PNC 602



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 61/203 (30%), Positives = 77/203 (37%), Gaps = 26/203 (12%)

Query: 984  QCWCQPGVTGKKCDRCAHGYFNFQE-----GGCTACECSHLGNNCDPKTGRCICPPNTIG 1038
            QC C  G  G+ C  CA GY          G C  C C   G  CDP TG C        
Sbjct: 381  QCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQG-GGACDPDTGDCYSGDENPD 439

Query: 1039 EKCSKCAPNTWGHSITT-GCKACNCSTVGSLDFQCNVNTGQCN-CHPKFSGAKCTECSRG 1096
             +C+ C    +        CK C C    S           CN C P  +GA+C  C+ G
Sbjct: 440  IECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADG 499

Query: 1097 HWNYP--------RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT-CKVNVEGIHCDR 1147
            ++  P         C  C C             +   +C   TG+C  C  N  GI+CD+
Sbjct: 500  YFGDPFGEHGPVRPCQPCQC-------NNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQ 552

Query: 1148 CRPGKFGLD-AKNPLG-CSSCYC 1168
            C+ G FG   A NP   C +C C
Sbjct: 553  CKAGYFGDPLAPNPADKCRACNC 575



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 57/169 (33%), Positives = 74/169 (43%), Gaps = 25/169 (14%)

Query: 816 NNFSPTCHLDRSL------GLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCND 869
           N  S  C  DR L      G  C  C     G  CE+C  G++         C PC CN 
Sbjct: 31  NGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRE--RDRCLPCNCNS 88

Query: 870 NLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQP-------CRCNA 922
               S+   CD+ SG C  CKPG TG  C+ C  G F    DA   Q        C C+ 
Sbjct: 89  K--GSLSARCDN-SGRCS-CKPGVTGARCDRCLPG-FHMLTDAGCTQDQRLLDSKCDCDP 143

Query: 923 GGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQ--SARGCVPCNC 969
            G  +  C +  G+C C+  V G+RCD+C++G + L   +  GC  C C
Sbjct: 144 AG-IAGPCDA--GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 53/184 (28%), Positives = 76/184 (41%), Gaps = 34/184 (18%)

Query: 287 CICYGHARACPLDPATNKSRCE-CEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACN 345
           C C+ +  +C + P T +  C  C     G  C+ C  G+   P+  G       C+ C 
Sbjct: 462 CPCH-NGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPF--GEHGPVRPCQPCQ 518

Query: 346 CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSP 405
           C+   +      N  R              G C+ C  NTAGI C+ C  G+F    ++P
Sbjct: 519 CNNNVDPSA-SGNCDRLT------------GRCLKCIHNTAGIYCDQCKAGYFGDP-LAP 564

Query: 406 NYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD 465
           N    C+ C+C+P+GS    C  D          G+C CK GFGG +C+       G   
Sbjct: 565 NPADKCRACNCNPMGSEPVGCRSD----------GTCVCKPGFGGPNCEH------GAFS 608

Query: 466 CKAC 469
           C AC
Sbjct: 609 CPAC 612



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/117 (26%), Positives = 41/117 (35%), Gaps = 28/117 (23%)

Query: 303 NKSRCECEHNTCGDSCDQCCPGFHQKPWRAGT---FLTKTECEACNCHGKAEECYYDENV 359
           N  RC C+    G  CD+C PGFH       T    L  ++C+ C+  G A  C      
Sbjct: 98  NSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCD-CDPAGIAGPC------ 150

Query: 360 ARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHC 416
                           G C+ C     G  C+ C  G++   G     P  C  C C
Sbjct: 151 --------------DAGRCV-CKPAVTGERCDRCRSGYYNLDG---GNPEGCTQCFC 189



 Score = 35.0 bits (79), Expect = 1.2
 Identities = 20/80 (25%), Positives = 31/80 (38%), Gaps = 19/80 (23%)

Query: 1106 CDCFLPGTDATTCDSETKKCSCSDQTGQC-----------------TCKVNVEGIHCDRC 1148
            C CF     A    S  + C C+ ++ QC                  C  N +GIHC++C
Sbjct: 9    CLCFSLLLPAARATSRREVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKC 68

Query: 1149 RPGKFGLDAKNPLGCSSCYC 1168
            + G +    ++   C  C C
Sbjct: 69   KNGFYRHRERD--RCLPCNC 86


>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
          Length = 1786

 Score =  306 bits (783), Expect = 3e-82
 Identities = 150/352 (42%), Positives = 197/352 (55%), Gaps = 25/352 (7%)

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGP 783
            C C  G     C+ C P H           C+PCQC GHA+ CD VTGECLNC+D+T G 
Sbjct: 840  CHCFQGVYARQCDRCLPGHWGFPS------CQPCQCNGHADDCDPVTGECLNCQDYTMGH 893

Query: 784  YCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNN-FSPTCHLDR-SLGLICDGCPVGYTG 841
             C++CL G+YG+P  G+ + C+PC CP    S   F+ +C+ D  +L L C  C  GY G
Sbjct: 894  NCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACV-CDPGYIG 952

Query: 842  PRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELC 901
             RC+ CA GYFG PS  GGSCQPCQC++N+D + P +CD  +G CL C   T G +C+ C
Sbjct: 953  SRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQFC 1012

Query: 902  ADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQ-------TGQCECRANVQGQRCDKCKAG 954
              GY+GDA+  ++C+ C CN  G+  E C+         TGQC C  NV GQ CD+C   
Sbjct: 1013 RFGYYGDALQ-QDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPN 1071

Query: 955  TFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTA 1013
            T+ L S  GC PCNCN+  S    C E +GQC C PG  G+ C  C   ++   +  C A
Sbjct: 1072 TWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPDVECRA 1131

Query: 1014 CECSHLG---NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHS-ITTGCKACN 1061
            C+C   G     CD  TG+C+C     G +C KC   T G+S +   C  C+
Sbjct: 1132 CDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKC---TRGYSGVFPDCTPCH 1180



 Score =  265 bits (677), Expect = 5e-70
 Identities = 158/453 (34%), Positives = 208/453 (45%), Gaps = 74/453 (16%)

Query: 752  GICEPCQCFGHAES-CDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACP 810
            G+   C   G   S CD   G+C  C+ +  G  C++C PG +G    G    C+PC C 
Sbjct: 770  GLACECDPQGSLSSVCDPNGGQC-QCRPNVVGRTCNRCAPGTFGFGPSG----CKPCECH 824

Query: 811  LNIPSNNF----SPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQ 866
            L    N F    +  CH           C  G    +C+RC  G++G PS     CQPCQ
Sbjct: 825  LQGSVNAFCNPVTGQCH-----------CFQGVYARQCDRCLPGHWGFPS-----CQPCQ 868

Query: 867  CNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAV--DAKNCQPCRC---- 920
            CN + D      CD ++G CL C+  T G  CE C  GY+GD +     +C+PC C    
Sbjct: 869  CNGHAD-----DCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGP 923

Query: 921  NAGGSFSEVCHSQTGQ----CECRANVQGQRCDKCKAGTFGLQSARG--CVPCNC-NSFG 973
            ++G  F+  C+         C C     G RCD C +G FG  S  G  C PC C N+  
Sbjct: 924  DSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNID 983

Query: 974  SKSFDC--EESGQCW-CQPGVTGKKCDRCAHGYF-NFQEGGCTACECSHLGN-------- 1021
            +   +   +E+G+C  C     G+ C  C  GY+ +  +  C  C C++LG         
Sbjct: 984  TTDPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGS 1043

Query: 1022 --NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQC 1079
               CD  TG+C+C PN IG+ C +CAPNTW  +  TGC  CNC+   S    CN  TGQC
Sbjct: 1044 DCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQC 1103

Query: 1080 NCHPKFSGAKCTECSRGHWNYP--RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCK 1137
             C P F G  C+EC    W  P   C  CDC   G +   CD           TGQC C 
Sbjct: 1104 QCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQCD---------QSTGQCVCV 1154

Query: 1138 VNVEGIHCDRCRPGKFGLDAKNPLGCSSCY-CF 1169
              VEG  CD+C  G  G+       C+ C+ CF
Sbjct: 1155 EGVEGPRCDKCTRGYSGVFP----DCTPCHQCF 1183



 Score =  229 bits (584), Expect = 3e-59
 Identities = 166/552 (30%), Positives = 243/552 (44%), Gaps = 64/552 (11%)

Query: 8   LLLLLLSGGLGGVQAQ-RPQQQRQSQAHQQRGLFPAV--LNLASNALITTNATCGEKGPE 64
           LL LL    L   +A+ R Q+   S    +   +PA   L +     ++  +TCG   PE
Sbjct: 3   LLQLLAFSFLALCRARVRAQEPEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPE 62

Query: 65  MYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKNT---------WWQSPSI 115
            YC +V H+      + +C ICN         +P ++ I+   T         WWQS   
Sbjct: 63  PYC-IVSHLQ----EDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQS--- 114

Query: 116 KNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTE 175
           +NG+E   VTI LDL+  F   ++I+    + RP   ++ERS D    K W  +     +
Sbjct: 115 ENGVEN--VTIQLDLEAEFHFTHLIM-TFKTFRPAAMLIERSSDFG--KTWGVYRYFAYD 169

Query: 176 CLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDP-SPELLE 234
           C   +   P        K D++IC S YS I P   GE+    ++     +DP SP +  
Sbjct: 170 CEASF---PGISTGPMKKVDDIICDSRYSDIEPSTEGEVIFRALDPAFKIEDPYSPRIQN 226

Query: 235 FTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHAR 294
                 +R++F ++ TL  D ++ +  + RE       +YYY+V D+ V G C CYGHA 
Sbjct: 227 LLKITNLRIKFVKLHTLG-DNLLDSRMEIRE-------KYYYAVYDMVVRGNCFCYGHAS 278

Query: 295 AC-PLDPATNK------SRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCH 347
            C P+D    +        C C HNT G +C+ C   +H  PWR         C+ CNC+
Sbjct: 279 ECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCN 338

Query: 348 GKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNY 407
             +  C++D       +++ +    + GGVC +C  NT G NCE C   +++        
Sbjct: 339 EHSISCHFD-------MAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRD 391

Query: 408 PRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD-- 465
           P  C+ C CDP GS NE           GL  G C CK    G  CD C  G+       
Sbjct: 392 PNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSED 451

Query: 466 ---CKACNCSGLGS-KNEDPC---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDEC 518
              CK+C C+ LG+    +PC    G C CK  V G  C +C    + L  D   GC  C
Sbjct: 452 PFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSND-LDGCRPC 510

Query: 519 FC---SGVSNRC 527
            C     ++N C
Sbjct: 511 DCDLGGALNNSC 522



 Score =  171 bits (434), Expect = 8e-42
 Identities = 100/292 (34%), Positives = 137/292 (46%), Gaps = 41/292 (14%)

Query: 918  CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSF 977
            C C+  GS S VC    GQC+CR NV G+ C++C  GTFG   + GC PC C+  GS + 
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPS-GCKPCECHLQGSVNA 831

Query: 978  DCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCI-CPPN 1035
             C   +GQC C  GV  ++CDRC  G++ F    C  C+C+   ++CDP TG C+ C   
Sbjct: 832  FCNPVTGQCHCFQGVYARQCDRCLPGHWGFPS--CQPCQCNGHADDCDPVTGECLNCQDY 889

Query: 1036 TIGEKCSKCAPNTWGHSITTG---CKACNCSTVGSLDFQCNVNTGQ--------CNCHPK 1084
            T+G  C +C    +G  I      C+ C C        Q   +  Q        C C P 
Sbjct: 890  TMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDPG 949

Query: 1085 FSGAKCTECSRGHWNYPR-----CNLCDCF--LPGTDATTCDSETKKCSCSDQTGQCTCK 1137
            + G++C +C+ G++  P      C  C C   +  TD   CD ET +C          C 
Sbjct: 950  YIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRC--------LKCL 1001

Query: 1138 VNVEGIHCDRCRPGKFGLDAK---------NPLGCSSCYCFGTTTQCSEAKG 1180
             + EG HC  CR G +G DA          N LG    +C G+  QC +A G
Sbjct: 1002 YHTEGEHCQFCRFGYYG-DALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATG 1052



 Score =  167 bits (424), Expect = 1e-40
 Identities = 181/835 (21%), Positives = 319/835 (38%), Gaps = 162/835 (19%)

Query: 1373 PADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGH-----SS 1427
            P  L   C C  GY G  C+ C  G++   S+ GG        +C PCQC+ +       
Sbjct: 937  PVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGG--------SCQPCQCHNNIDTTDPE 988

Query: 1428 LCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFS------ 1481
             CD ET  C  C +HT G+ C+ C  GYYG    L  DC++C C  + +           
Sbjct: 989  ACDKETGRCLKCLYHTEGEHCQFCRFGYYG--DALQQDCRKCVCNYLGTVQEHCNGSDCQ 1046

Query: 1482 -----------PSCVAE----------------GLDDYRCTA----------------CP 1498
                       P+ + +                G D   C A                C 
Sbjct: 1047 CDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCM 1106

Query: 1499 RGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558
             G+ G+ C  C   + G   +P   C+ C+CDP G     CD  TG C C  G  G +CD
Sbjct: 1107 PGFGGRTCSECQELFWG---DPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCD 1163

Query: 1559 GCKHWHAREGWECVFCGDECTGL---LLGDLA----RLEQMVMSINLTGPLPAPYKMLYG 1611
             C   ++    +C  C  +C  L   ++ +L     R  +   ++ ++G +    + +  
Sbjct: 1164 KCTRGYSGVFPDCTPC-HQCFALWDVIIAELTNRTHRFLEKAKALKISGVIGPYRETVDS 1222

Query: 1612 LENMTQELKHLLSPQRAPE------RLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTG 1665
            +E    E+K +L+   A E       L + AE  +  +   M ++  + +  T+    T 
Sbjct: 1223 VERKVSEIKDILAQSPAAEPLKNIGNLFEEAEKLIKDVTEMMAQVEVKLSDTTSQSNSTA 1282

Query: 1666 QDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQK------ 1719
            ++ +   T A+SL   +KELA   E +    I+    L +  + F+ +LE  ++      
Sbjct: 1283 KELDSLQTEAESLDNTVKELAEQLEFIKNSDIR--GALDSITKYFQMSLEAEERVNASTT 1340

Query: 1720 ----EIDQ------MIKELRRKNLETQKEIAEDELVAAEALLKKVKKLF----------- 1758
                 ++Q       ++++  +     KE  E++    + L  K++ L            
Sbjct: 1341 EPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELAGKLQSLDLSAAAEMTCGT 1400

Query: 1759 --GESRGENEEMEKDLREKLADYK--------------NKVDDAWDLLREATDKIREANR 1802
              G S  E E    + R    + K              N    A DL ++    + E  +
Sbjct: 1401 PPGASCSETECGGPNCRTDEGERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSALAEVEQ 1460

Query: 1803 LF-AVNQKNMTALEKK-------------KEAVESGKRQIENTLKEGNDILDEANRLADE 1848
            L   V++  + A E K             KE ++    ++ N +K+  + L + +   D 
Sbjct: 1461 LSKMVSEAKLRADEAKQSAEDILLKTNATKEKMDKSNEELRNLIKQIRNFLTQDSADLDS 1520

Query: 1849 INSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLD 1908
            I ++ +  E ++ ++P   ++L +  +D+      R+  E +SQ E          A  +
Sbjct: 1521 IEAVAN--EVLKMEMPSTPQQLQNLTEDI------RERVESLSQVEVILQHSAADIARAE 1572

Query: 1909 GILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLL----- 1963
             +L+EAK  S +AT        +K+ ++EAEK    A+    +A +   G + LL     
Sbjct: 1573 MLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIES 1632

Query: 1964 -----KEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTLND 2018
                 +E      Q+   +    ++L     +N      ++  +        D+ +TL+ 
Sbjct: 1633 ETAASEETLFNASQRISELERNVEELKRKAAQNSGEAEYIEKVVYTVKQSAEDVKKTLDG 1692

Query: 2019 TLG-KLSAIPNDTAAKLQAVKD---KARQANDTAKDVLAQITELHQNLDGLKKNY 2069
             L  K   + N  A K +   D   KA    + AK +LAQ     Q L  L++ Y
Sbjct: 1693 ELDEKYKKVENLIAKKTEESADARRKAEMLQNEAKTLLAQANSKLQLLKDLERKY 1747



 Score =  143 bits (360), Expect = 3e-33
 Identities = 89/287 (31%), Positives = 132/287 (45%), Gaps = 48/287 (16%)

Query: 757  CQCFGHAESCDDVT-----------GECLNCKDHTGGPYCDKCLPGFYG---EPTKG-TS 801
            C C+GHA  C  V            G C+ C+ +T G  C+ C+  ++     P +G  S
Sbjct: 271  CFCYGHASECAPVDGFNEEVEGMVHGHCM-CRHNTKGLNCELCMDFYHDLPWRPAEGRNS 329

Query: 802  EDCQPCACPLNIPSNNFSPTCHLDRSL--------GLICDGCPVGYTGPRCERCAEGYFG 853
              C+ C C      N  S +CH D ++        G +CD C     G  CE+C   Y+ 
Sbjct: 330  NACKKCNC------NEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQ 383

Query: 854  QPS---VPGGSCQPCQCNDNLDFSIPGSCDS--------LSGSCLICKPGTTGRYCELCA 902
             P         C+ C C D       G CDS        ++G C  CK    G +C++C 
Sbjct: 384  HPERDIRDPNFCERCTC-DPAGSQNEGICDSYTDFSTGLIAGQCR-CKLNVEGEHCDVCK 441

Query: 903  DGYFG-DAVDAKNCQPCRCNAGGSF--SEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQ 959
            +G++   + D   C+ C CN  G+      C S+TG C C+  V GQ CD+C    +GL 
Sbjct: 442  EGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLS 501

Query: 960  S-ARGCVPCNCNSFGSKSFDC-EESGQCWCQPGVTGKKCDRCAHGYF 1004
            +   GC PC+C+  G+ +  C  ESGQC C+P + G++C+    GY+
Sbjct: 502  NDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYY 548



 Score =  135 bits (340), Expect = 6e-31
 Identities = 80/278 (28%), Positives = 121/278 (43%), Gaps = 43/278 (15%)

Query: 860  GSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYF------GDAVDAK 913
            G    C   D  +  + G    + G C+ C+  T G  CELC D Y        +  ++ 
Sbjct: 275  GHASECAPVDGFNEEVEGM---VHGHCM-CRHNTKGLNCELCMDFYHDLPWRPAEGRNSN 330

Query: 914  NCQPCRCNAGG---SFSEVCHSQTGQC------ECRANVQGQRCDKCKAGTF-----GLQ 959
             C+ C CN       F    +  TG        +C+ N  G+ C++CK   +      ++
Sbjct: 331  ACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIR 390

Query: 960  SARGCVPCNCNSFGSKSFDCEES----------GQCWCQPGVTGKKCDRCAHGYFNFQEG 1009
                C  C C+  GS++    +S          GQC C+  V G+ CD C  G+++    
Sbjct: 391  DPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSE 450

Query: 1010 ---GCTACECSHLG-----NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITT-GCKAC 1060
               GC +C C+ LG     N CD +TG C C     G+ C +C P  WG S    GC+ C
Sbjct: 451  DPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPC 510

Query: 1061 NCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHW 1098
            +C   G+L+  C   +GQC+C P   G +C E   G++
Sbjct: 511  DCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYY 548



 Score =  133 bits (334), Expect = 3e-30
 Identities = 72/188 (38%), Positives = 89/188 (47%), Gaps = 18/188 (9%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            +C C  G     C+ CLPG +   S             C PCQCNGH+  CDP T  C N
Sbjct: 839  QCHCFQGVYARQCDRCLPGHWGFPS-------------CQPCQCNGHADDCDPVTGECLN 885

Query: 1439 CQHHTAGDFCERCALGYYG-IVKGLPNDCQQCACP-LISSSNNFSPSCVAEGLDDYRCTA 1496
            CQ +T G  CERC  GYYG  + G  + C+ C CP    S   F+ SC  + +       
Sbjct: 886  CQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACV 945

Query: 1497 CPRGYEGQYCERCAPGYTGSPGNPGGSCQECEC--DPYGSLPVPCDPVTGFC-TCRPGAT 1553
            C  GY G  C+ CA GY G+P   GGSCQ C+C  +   + P  CD  TG C  C     
Sbjct: 946  CDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTE 1005

Query: 1554 GRKCDGCK 1561
            G  C  C+
Sbjct: 1006 GEHCQFCR 1013



 Score =  127 bits (319), Expect = 2e-28
 Identities = 75/254 (29%), Positives = 119/254 (46%), Gaps = 24/254 (9%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGG----ICEPCQCFGHAESCD-DVT-------- 770
           C C     G +CE C   +  +      G     C+ C C  H+ SC  D+         
Sbjct: 298 CMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATGNV 357

Query: 771 --GECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED--CQPCACPLNIPSNNFSPTCHLDR 826
             G C +C+ +T G  C++C P +Y  P +   +   C+ C C      N      + D 
Sbjct: 358 SGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDF 417

Query: 827 SLGLICDGC--PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGS--CDSL 882
           S GLI   C   +   G  C+ C EG++   S     C+ C CN     +IPG   CDS 
Sbjct: 418 STGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPL--GTIPGGNPCDSE 475

Query: 883 SGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRAN 942
           +G C  CK   TG++C+ C   ++G + D   C+PC C+ GG+ +  C +++GQC CR +
Sbjct: 476 TGHCY-CKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPH 534

Query: 943 VQGQRCDKCKAGTF 956
           + G++C++ + G +
Sbjct: 535 MIGRQCNEVEPGYY 548



 Score =  110 bits (274), Expect = 3e-23
 Identities = 65/205 (31%), Positives = 93/205 (45%), Gaps = 25/205 (12%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSI---- 1435
            C C     GL+CE C+  ++ L  +P     G     C  C CN HS  C  + ++    
Sbjct: 298  CMCRHNTKGLNCELCMDFYHDLPWRPA---EGRNSNACKKCNCNEHSISCHFDMAVYLAT 354

Query: 1436 -------CQNCQHHTAGDFCERCALGYYGIVKGL---PNDCQQCACPLISSSNNF---SP 1482
                   C +CQH+T G  CE+C   YY   +     PN C++C C    S N     S 
Sbjct: 355  GNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSY 414

Query: 1483 SCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPV--PCD 1540
            +  + GL   +C  C    EG++C+ C  G+          C+ C C+P G++P   PCD
Sbjct: 415  TDFSTGLIAGQCR-CKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCD 473

Query: 1541 PVTGFCTCRPGATGRKCDGC--KHW 1563
              TG C C+   TG+ CD C  +HW
Sbjct: 474  SETGHCYCKRLVTGQHCDQCLPEHW 498



 Score =  107 bits (268), Expect = 1e-22
 Identities = 80/285 (28%), Positives = 109/285 (38%), Gaps = 56/285 (19%)

Query: 912  AKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGL-------QSARGC 964
            A  C P      G   EV     G C CR N +G  C+ C      L       +++  C
Sbjct: 277  ASECAP----VDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNAC 332

Query: 965  VPCNCNSFG-SKSFDCE--------ESGQCW-CQPGVTGKKCDRCAHGYFNFQEGG---- 1010
              CNCN    S  FD            G C  CQ    G+ C++C   Y+   E      
Sbjct: 333  KKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDP 392

Query: 1011 --CTACECSHLGNN----CDPKT--------GRCICPPNTIGEKCSKCAPNTWGHSITT- 1055
              C  C C   G+     CD  T        G+C C  N  GE C  C    +  S    
Sbjct: 393  NFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDP 452

Query: 1056 -GCKACNCSTVGSLDF--QCNVNTGQCNCHPKFSGAKCTECSRGHWNYPR----CNLCDC 1108
             GCK+C C+ +G++     C+  TG C C    +G  C +C   HW        C  CDC
Sbjct: 453  FGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDC 512

Query: 1109 FLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKF 1153
             L G    +C +E+         GQC+C+ ++ G  C+   PG +
Sbjct: 513  DLGGALNNSCFAES---------GQCSCRPHMIGRQCNEVEPGYY 548



 Score =  100 bits (249), Expect = 2e-20
 Identities = 73/269 (27%), Positives = 103/269 (38%), Gaps = 57/269 (21%)

Query: 293  ARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC---------EA 343
            AR+C  DP T +  C C+    G  CD C  G+   P   G      +C         EA
Sbjct: 930  ARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEA 989

Query: 344  CN----------CHGKAEEC------YYDENVAR--RNLSLNIRG---KYIGGGVC---- 378
            C+           H + E C      YY + + +  R    N  G   ++  G  C    
Sbjct: 990  CDKETGRCLKCLYHTEGEHCQFCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDK 1049

Query: 379  ----INCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHAR 434
                  C  N  G NC+ C    ++    +      C PC+C+   S    C +      
Sbjct: 1050 ATGQCLCLPNVIGQNCDRCAPNTWQLASGTG-----CDPCNCNAAHSFGPSCNE------ 1098

Query: 435  RGLAPGSCHCKTGFGGVSCDRCARGYTGYPD--CKACNCS--GLGSKNEDPCFGPCICKE 490
                 G C C  GFGG +C  C   + G PD  C+AC+C   G+ +   D   G C+C E
Sbjct: 1099 ---FTGQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVE 1155

Query: 491  NVEGGDCSRCKSGFFNLQEDNWKGCDECF 519
             VEG  C +C  G+  +  D    C +CF
Sbjct: 1156 GVEGPRCDKCTRGYSGVFPD-CTPCHQCF 1183



 Score = 89.7 bits (221), Expect = 4e-17
 Identities = 77/277 (27%), Positives = 105/277 (37%), Gaps = 54/277 (19%)

Query: 287  CICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNC 346
            C C GHA  C  DP T +    C+  T G +C++C  G++  P       +   C  C C
Sbjct: 867  CQCNGHADDC--DPVTGEC-LNCQDYTMGHNCERCLAGYYGDP----IIGSGDHCRPCPC 919

Query: 347  -----HGK--AEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFR 399
                  G+  A  CY D       ++L +         C+ C     G  C+ C  G+F 
Sbjct: 920  PDGPDSGRQFARSCYQDP------VTLQL--------ACV-CDPGYIGSRCDDCASGYF- 963

Query: 400  PKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC-HCKTGFGGVSCDRCAR 458
              G        CQPC C      N +   D +   +    G C  C     G  C  C  
Sbjct: 964  --GNPSEVGGSCQPCQCH-----NNIDTTDPEACDK--ETGRCLKCLYHTEGEHCQFCRF 1014

Query: 459  GYTG---YPDCKACNCSGLGSKNE---------DPCFGPCICKENVEGGDCSRCKSGFFN 506
            GY G     DC+ C C+ LG+  E         D   G C+C  NV G +C RC    + 
Sbjct: 1015 GYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQ 1074

Query: 507  LQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMSGW 543
            L      GCD C C+   +   S     G+ Q M G+
Sbjct: 1075 LASGT--GCDPCNCNAAHSFGPSCNEFTGQCQCMPGF 1109



 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 78/291 (26%), Positives = 114/291 (39%), Gaps = 74/291 (25%)

Query: 295  ACPLDPA--------TNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTF-LTKTECEACN 345
            AC  DP          N  +C+C  N  G +C++C P         GTF    + C+ C 
Sbjct: 772  ACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAP---------GTFGFGPSGCKPCE 822

Query: 346  CHGKAE----------ECYYDENVARRNLSLNIRGKY---------IGG---------GV 377
            CH +            +C+  + V  R     + G +           G         G 
Sbjct: 823  CHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQPCQCNGHADDCDPVTGE 882

Query: 378  CINCTQNTAGINCETCTDGFF-RPKGVSPNYPRPCQPCHCDPIG--SLNEVCVKDEKHAR 434
            C+NC   T G NCE C  G++  P   S ++ RPC PC   P         C +D    +
Sbjct: 883  CLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPC-PCPDGPDSGRQFARSCYQDPVTLQ 941

Query: 435  RGLAPGSCHCKTGFGGVSCDRCARGYTGYP-----DCKACNC-SGLGSKNEDPC---FGP 485
                  +C C  G+ G  CD CA GY G P      C+ C C + + + + + C    G 
Sbjct: 942  L-----ACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGR 996

Query: 486  CI-CKENVEGGDCSRCKSGFFN--LQEDNWKGCDECFCS---GVSNRCQSS 530
            C+ C  + EG  C  C+ G++   LQ+D    C +C C+    V   C  S
Sbjct: 997  CLKCLYHTEGEHCQFCRFGYYGDALQQD----CRKCVCNYLGTVQEHCNGS 1043



 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 55/168 (32%), Positives = 74/168 (44%), Gaps = 30/168 (17%)

Query: 1028 GRCICPPNTIGEKCSKCAPNTWGHSI---------TTGCKACNCSTVG-SLDFQC----- 1072
            G C+C  NT G  C  C    + H +         +  CK CNC+    S  F       
Sbjct: 296  GHCMCRHNTKGLNCELCMD--FYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLA 353

Query: 1073 --NVNTGQCN-CHPKFSGAKCTECSRGHWNYPR--------CNLCDCFLPGT-DATTCDS 1120
              NV+ G C+ C     G  C +C   ++ +P         C  C C   G+ +   CDS
Sbjct: 354  TGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDS 413

Query: 1121 ETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC 1168
             T   S     GQC CK+NVEG HCD C+ G + L +++P GC SC C
Sbjct: 414  YTD-FSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCAC 460



 Score = 72.4 bits (176), Expect = 7e-12
 Identities = 77/253 (30%), Positives = 104/253 (41%), Gaps = 49/253 (19%)

Query: 702 SVNLESAVSYPTDGSIAAAVEVCQ-CPPGYTGSSCESCWPRH-----RRVNGTIFGGICE 755
           S + + AV Y   G+++  V  C  C     G +CE C P +     R +    F   CE
Sbjct: 343 SCHFDMAV-YLATGNVSGGV--CDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNF---CE 396

Query: 756 PCQCFGHAES----CDDVT--------GECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED 803
            C C          CD  T        G+C  CK +  G +CD C  GFY      +SED
Sbjct: 397 RCTCDPAGSQNEGICDSYTDFSTGLIAGQC-RCKLNVEGEHCDVCKEGFYDL----SSED 451

Query: 804 ---CQPCAC-PLN-IPSNN--FSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPS 856
              C+ CAC PL  IP  N   S T H           C    TG  C++C   ++G  +
Sbjct: 452 PFGCKSCACNPLGTIPGGNPCDSETGHCY---------CKRLVTGQHCDQCLPEHWGLSN 502

Query: 857 VPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQ 916
              G C+PC C+  L  ++  SC + SG C  C+P   GR C     GY+   +D    +
Sbjct: 503 DLDG-CRPCDCD--LGGALNNSCFAESGQCS-CRPHMIGRQCNEVEPGYYFATLDHYLYE 558

Query: 917 PCRCNAGGSFSEV 929
               N G   S V
Sbjct: 559 AEEANLGPGVSIV 571



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 52/172 (30%), Positives = 69/172 (40%), Gaps = 31/172 (18%)

Query: 1420 CQCNGHSSLCDPETSICQN----------CQHHTAGDFCERCALGYYGIVKGLP------ 1463
            C C GH+S C P     +           C+H+T G  CE C + +Y  +   P      
Sbjct: 271  CFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELC-MDFYHDLPWRPAEGRNS 329

Query: 1464 NDCQQCACPLISSSNNFSPSC-VAEG-LDDYRCTACPRGYEGQYCERCAPGYTGSPG--- 1518
            N C++C C   S S +F  +  +A G +    C  C     G+ CE+C P Y   P    
Sbjct: 330  NACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDI 389

Query: 1519 NPGGSCQECECDPYGSLPVP-CDPVTGF--------CTCRPGATGRKCDGCK 1561
                 C+ C CDP GS     CD  T F        C C+    G  CD CK
Sbjct: 390  RDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCK 441



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 45/141 (31%), Positives = 62/141 (43%), Gaps = 24/141 (17%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQ-PGGRTPGPTLGTCVPCQCNGHSSL-----CDPE 1432
            +C C L   G  C+ C  GFY L S+ P G         C  C CN   ++     CD E
Sbjct: 425  QCRCKLNVEGEHCDVCKEGFYDLSSEDPFG---------CKSCACNPLGTIPGGNPCDSE 475

Query: 1433 TSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDY 1492
            T  C  C+    G  C++C   ++G+   L + C+ C C L  + NN   SC AE     
Sbjct: 476  TGHCY-CKRLVTGQHCDQCLPEHWGLSNDL-DGCRPCDCDLGGALNN---SCFAE---SG 527

Query: 1493 RCTACPRGYEGQYCERCAPGY 1513
            +C+  P    G+ C    PGY
Sbjct: 528  QCSCRPH-MIGRQCNEVEPGY 547



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 31/69 (44%), Positives = 36/69 (52%), Gaps = 5/69 (7%)

Query: 1497 CPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556
            C     G+ C RCAPG  G    P G C+ CEC   GS+   C+PVTG C C  G   R+
Sbjct: 794  CRPNVVGRTCNRCAPGTFGF--GPSG-CKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQ 850

Query: 1557 CDGC--KHW 1563
            CD C   HW
Sbjct: 851  CDRCLPGHW 859



 Score = 52.4 bits (124), Expect = 7e-06
 Identities = 39/121 (32%), Positives = 48/121 (39%), Gaps = 16/121 (13%)

Query: 1057 CKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLC-------DCF 1109
            CK+ +  TVG        N+        F   +C E SR     P  ++C          
Sbjct: 710  CKSLDIFTVGGSGDGVVTNSAW----ETFQRYRCLENSRSVVKTPMTDVCRNIIFSISAL 765

Query: 1110 LPGTD-ATTCDSETKKCS-CSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCY 1167
            L  T  A  CD +    S C    GQC C+ NV G  C+RC PG FG     P GC  C 
Sbjct: 766  LHQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGF---GPSGCKPCE 822

Query: 1168 C 1168
            C
Sbjct: 823  C 823



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 20/34 (58%), Positives = 21/34 (61%)

Query: 1527 CECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
            CECDP GSL   CDP  G C CRP   GR C+ C
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRC 806



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 25/78 (32%), Positives = 33/78 (42%), Gaps = 9/78 (11%)

Query: 468 ACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCD-------EC 518
           AC C   GS +   DP  G C C+ NV G  C+RC  G F       K C+         
Sbjct: 772 ACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 519 FCSGVSNRCQSSYWTYGK 536
           FC+ V+ +C      Y +
Sbjct: 832 FCNPVTGQCHCFQGVYAR 849


>gi|219842266 usherin isoform B [Homo sapiens]
          Length = 5202

 Score =  275 bits (704), Expect = 4e-73
 Identities = 171/471 (36%), Positives = 229/471 (48%), Gaps = 52/471 (11%)

Query: 723  VCQ-CPPGYTGSSCESCWPRHRRVNGTIFGGI--CEPCQCF-----GHAESCDDVTGECL 774
            VC  C    TG +CE C     R  G     I  C+PC C        +  CD + G+C 
Sbjct: 604  VCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC- 662

Query: 775  NCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDG 834
            NCK H  G  C++C  GFY        + C PC C  +   +    TCH +      C  
Sbjct: 663  NCKRHVSGRQCNQCQNGFYNLQELDP-DGCSPCNCNTSGTVDG-DITCHQNSGQ---CK- 716

Query: 835  CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTT 894
            C     G RC+ C  G+    S     C+PCQCN  L  S+   C+  SG C  CK    
Sbjct: 717  CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCN--LHGSVNKFCNPHSGQCE-CKKEAK 773

Query: 895  GRYCELCADGYFGDAVDAKNCQPCRCNAGGSF-SEVCHSQTGQCECRANVQGQRCDKCKA 953
            G  C+ C + ++G  +D  NC+ C C+  GS    VC+++TGQC C+ NV+G++C+KC  
Sbjct: 774  GLQCDTCRENFYG--LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLE 831

Query: 954  GTFGLQSARG--CVPCNCNSFGS--KSFDCEES-GQCWCQPGVTGKKCDRCA-HGYF--- 1004
            G F L+      C+PCNC+  G+   S  C +S GQC C+ GVTG +C++C  H Y    
Sbjct: 832  GNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTI 891

Query: 1005 -NFQEGGCTACECSHLGNN----CDPKTGRCICPPNTIGEKCSKCAPNTW-GHSITTGCK 1058
             NFQ   C  CEC  LG      CDP +G+C+C PN  G +C++C P  +      TGC 
Sbjct: 892  DNFQH--CQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCL 949

Query: 1059 ACNCSTVGSLDFQCNVNTGQCNCHP-KFSGAKCTECSRGHWNYP----RCNLCDCFLPGT 1113
             C+C T G+++  CN  TGQC C     +G +C +C   ++ +     RC  C+C L G 
Sbjct: 950  PCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGA 1009

Query: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCS 1164
               TC   T         GQC CK  V G  CD C P    LD  N LGCS
Sbjct: 1010 LNETCHLVT---------GQCFCKQFVTGSKCDACVPSASHLDVNNLLGCS 1051



 Score =  273 bits (699), Expect = 1e-72
 Identities = 154/456 (33%), Positives = 218/456 (47%), Gaps = 58/456 (12%)

Query: 757  CQCFGHAESCDDVTGECLNC----KDHTGGPYCDKCLPGFYGEPTKGTSE----DCQPCA 808
            CQC GHA++C D T +   C    +  T G +CD+CLP +  +P +   +    +C+PC 
Sbjct: 518  CQCHGHADNC-DTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQ 576

Query: 809  CPLNIPSNNFSPTCHLDRSL-----------GLICDGCPVGYTGPRCERCAEGYFGQPSV 857
            C      N+ S +CH + S+           G +CD C    TG  CE C + +F Q   
Sbjct: 577  C------NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGA 630

Query: 858  PGGS---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG-DAVDAK 913
               +   C+PC C+     +    CD + G C  CK   +GR C  C +G++    +D  
Sbjct: 631  DPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQELDPD 689

Query: 914  NCQPCRCNAGGSFSE--VCHSQTGQCECRANVQGQRCDKCKAGTFGLQSAR--GCVPCNC 969
             C PC CN  G+      CH  +GQC+C+ANV G RCD C  G   L+S    GC PC C
Sbjct: 690  GCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQC 749

Query: 970  NSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACEC----SHLGNNCD 1024
            N  GS +  C   SGQC C+    G +CD C   ++      C AC+C    S  G  C+
Sbjct: 750  NLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCN 809

Query: 1025 PKTGRCICPPNTIGEKCSKCAPNTW--GHSITTGCKACNCSTVGSLD--FQCNVNTGQCN 1080
             KTG+CIC PN  G +C+KC    +    + +  C  CNC   G+++    CN +TGQC 
Sbjct: 810  AKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCP 869

Query: 1081 CHPKFSGAKCTECSRGHW-----NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT 1135
            C    +G +C +C    +     N+  C +C+C   GT   T         C   +GQC 
Sbjct: 870  CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI--------CDPISGQCL 921

Query: 1136 CKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGT 1171
            C  N +G  C++C+PG F +   N  GC  C C  T
Sbjct: 922  CVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCHTT 956



 Score =  194 bits (492), Expect = 1e-48
 Identities = 138/449 (30%), Positives = 205/449 (45%), Gaps = 53/449 (11%)

Query: 92  NPNQRHPITNAIDGK-NTWWQSPSIKNGIEYHY-VTITLDLQQ-VFQIAYVIVKAANSPR 148
           NP + HP++   D    T W S    N  + +  VTI++DL+   +Q+ Y+I++   SP+
Sbjct: 336 NP-EAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFF-SPQ 393

Query: 149 PGNWILERSLDD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIH 207
           P    ++R  ++ ++++ WQY A     C      +         K D V C    S   
Sbjct: 394 PTEIRIQRKKENSLDWEDWQYFA---RNC----GAFGMKNNGDLEKPDSVNCLQL-SNFT 445

Query: 208 PLENGEIHISLI----NGRPSADD--PSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261
           P   G +  S++    N RP  ++   +P L EF  A  IR  F          +   H+
Sbjct: 446 PYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHR 505

Query: 262 DPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQC 321
                        YY+V +I++ G C C+GHA  C       +  C  E  T G  CD+C
Sbjct: 506 -------------YYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRC 552

Query: 322 CPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381
            P ++ KP+R G  +    C+ C C+  ++ C+Y+ +V       + RG   GGGVC +C
Sbjct: 553 LPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFE-HFRG---GGGVCDDC 608

Query: 382 TQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGS 441
             NT G NCE C D FFR  G  P+    C+PC CD +G+ N   + D+         G 
Sbjct: 609 EHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQ-------IGGQ 661

Query: 442 CHCKTGFGGVSCDRCARGYTGY----PD-CKACNCSGLGSKNED-PCF---GPCICKENV 492
           C+CK    G  C++C  G+       PD C  CNC+  G+ + D  C    G C CK NV
Sbjct: 662 CNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANV 721

Query: 493 EGGDCSRCKSGFFNLQEDNWKGCDECFCS 521
            G  C  C  GF  L+  N  GC+ C C+
Sbjct: 722 IGLRCDHCNFGFKFLRSFNDVGCEPCQCN 750



 Score =  181 bits (458), Expect = 1e-44
 Identities = 115/356 (32%), Positives = 165/356 (46%), Gaps = 66/356 (18%)

Query: 865  CQCNDNLDFSIPGSCDSLSGS--CLICKPG-TTGRYCELCADGYF------GDAVDAKNC 915
            CQC+ + D     +CD+ S    CL  +   T G +C+ C   Y       GD V A NC
Sbjct: 518  CQCHGHAD-----NCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNC 572

Query: 916  QPCRCNAGGSFSEVCHSQT--------------GQCE-CRANVQGQRCDKCKAGTFGLQS 960
            +PC+CN   S S+ CH                 G C+ C  N  G+ C+ CK   F    
Sbjct: 573  KPCQCN---SHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVG 629

Query: 961  ARG-----CVPCNCNSFGSK--SFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQE---G 1009
            A       C PC+C++ G++  S  C++  GQC C+  V+G++C++C +G++N QE    
Sbjct: 630  ADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPD 689

Query: 1010 GCTACECSHLGN-----NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSIT-----TGCKA 1059
            GC+ C C+  G       C   +G+C C  N IG +C  C    +G          GC+ 
Sbjct: 690  GCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHC---NFGFKFLRSFNDVGCEP 746

Query: 1060 CNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHW--NYPRCNLCDCFLPGTDATT 1117
            C C+  GS++  CN ++GQC C  +  G +C  C    +  +   C  CDC   G+   T
Sbjct: 747  CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGT 806

Query: 1118 CDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTT 1173
                     C+ +TGQC CK NVEG  C++C  G F L   N   C  C C  T T
Sbjct: 807  V--------CNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGT 854



 Score =  124 bits (312), Expect = 1e-27
 Identities = 86/289 (29%), Positives = 122/289 (42%), Gaps = 39/289 (13%)

Query: 692  FGMDAIFRLSSVNLESAVSYPTDGSIA-AAVEVCQCPPGYTGSSCESCWPR--HRRVNGT 748
            +G+D +    + + ++A S P  G++  A    C C P   G  C  C     + R N +
Sbjct: 785  YGLD-VTNCKACDCDTAGSLP--GTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNS 841

Query: 749  IFGGICEPCQC-----FGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED 803
                +C PC C        +  C+  TG+C  CK    G  C++C P  Y   T    + 
Sbjct: 842  F---LCLPCNCDKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQCEPHRYNL-TIDNFQH 896

Query: 804  CQPCACPLNIPSNNFSPTCHLDRSLGLICDG------CPVGYTGPRCERCAEGYFGQPSV 857
            CQ C C              L    G ICD       C     G RC +C  G++  P  
Sbjct: 897  CQMCECD------------SLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944

Query: 858  PGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQP 917
              G C PC C+     ++   C+SL+G C+       G+ C+ C D YFG       CQP
Sbjct: 945  ATG-CLPCSCHTT--GAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQP 1001

Query: 918  CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKC--KAGTFGLQSARGC 964
            C C+  G+ +E CH  TGQC C+  V G +CD C   A    + +  GC
Sbjct: 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050



 Score =  106 bits (264), Expect = 4e-22
 Identities = 70/223 (31%), Positives = 94/223 (42%), Gaps = 42/223 (18%)

Query: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
           +C C+ +  G  C+QC  GF+         L    C  CNC                N S
Sbjct: 661 QCNCKRHVSGRQCNQCQNGFYNLQE-----LDPDGCSPCNC----------------NTS 699

Query: 366 LNIRGK---YIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSL 422
             + G    +   G C  C  N  G+ C+ C  GF   K +       C+PC C+  GS+
Sbjct: 700 GTVDGDITCHQNSGQC-KCKANVIGLRCDHCNFGF---KFLRSFNDVGCEPCQCNLHGSV 755

Query: 423 NEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP--DCKACNCSGLGSKNED 480
           N+ C     H+      G C CK    G+ CD C   + G    +CKAC+C   GS    
Sbjct: 756 NKFC---NPHS------GQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGT 806

Query: 481 PC---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
            C    G CICK NVEG  C++C  G F L+++N   C  C C
Sbjct: 807 VCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 70/251 (27%), Positives = 102/251 (40%), Gaps = 51/251 (20%)

Query: 296 CPLDPATNK------SRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGK 349
           C L  + NK       +CEC+    G  CD C   F+         L  T C+AC+C   
Sbjct: 749 CNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYG--------LDVTNCKACDC--- 797

Query: 350 AEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPR 409
                 D   +      N +      G CI C  N  G  C  C +G F    +  N   
Sbjct: 798 ------DTAGSLPGTVCNAKT-----GQCI-CKPNVEGRQCNKCLEGNFY---LRQNNSF 842

Query: 410 PCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARG-----YTGYP 464
            C PC+CD  G++N   + ++       + G C CK G  G+ C++C           + 
Sbjct: 843 LCLPCNCDKTGTINGSLLCNK-------STGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895

Query: 465 DCKACNCSGLGSKNE---DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC- 520
            C+ C C  LG+      DP  G C+C  N +G  C++C+ GF+ +   N  GC  C C 
Sbjct: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCH 954

Query: 521 --SGVSNRCQS 529
               V++ C S
Sbjct: 955 TTGAVNHICNS 965



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 93/337 (27%), Positives = 149/337 (44%), Gaps = 38/337 (11%)

Query: 2789 IELEVRTEAESGLLFYMARI-NHADFATVQLRNGLPYFSYDLGSGDTHTMIPT----KIN 2843
            I+   RT+   GL+ + A   N  ++  +QL+ G  YF +D                + +
Sbjct: 1544 IKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYS 1603

Query: 2844 DGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGP 2901
            DG+WH+I  +R +  G + +DG    +  I      I D  G +++GGLP +YT  R  P
Sbjct: 1604 DGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTG-VFLGGLPRSYTILRKDP 1662

Query: 2902 --VTYSIDGCVRNLHMAE--------APADLEQPTSSFHVGT----CFANAQRGTYFDGT 2947
              +     GC++++H  +         P D +      +V      C A+   G  F G 
Sbjct: 1663 EIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGA 1722

Query: 2948 GFAKA-VGGFKVGLDLLVEFEFRTTTTTGVLLGI-SSQKMDGMGIEMIDEKLMFHVDNGA 3005
            GF +     F  G++  + F+FRT    G+LL + +    D + +E+    L F + N +
Sbjct: 1723 GFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRL-NTS 1781

Query: 3006 GRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSAD----TN 3061
              FT V D  +    C+G+W+KV   K    I  +V+G          AS S D     N
Sbjct: 1782 LAFTQV-DLLLGLSYCNGKWNKVIIKKEGSFISASVNGLM------KHASESGDQPLVVN 1834

Query: 3062 DPVFVGGFPDDL--KQFGLTTSIPFRGCIRSLKLTKG 3096
             PV+VGG P +L      L     F GC++ +K T+G
Sbjct: 1835 SPVYVGGIPQELLNSYQHLCLEQGFGGCMKDVKFTRG 1871



 Score = 92.0 bits (227), Expect = 8e-18
 Identities = 58/186 (31%), Positives = 75/186 (40%), Gaps = 21/186 (11%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
            +C C LG +GL C  C P  Y L               C  C+C+   +L    CDP + 
Sbjct: 867  QCPCKLGVTGLRCNQCEPHRYNLTID--------NFQHCQMCECDSLGTLPGTICDPISG 918

Query: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
             C  C  +  G  C +C  G+Y I  G    C  C+C    + N+   S   +      C
Sbjct: 919  QCL-CVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQ------C 970

Query: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATG 1554
                    GQ C++C   Y G     G  CQ C C   G+L   C  VTG C C+   TG
Sbjct: 971  VCQDASIAGQRCDQCKDHYFGFDPQTG-RCQPCNCHLSGALNETCHLVTGQCFCKQFVTG 1029

Query: 1555 RKCDGC 1560
             KCD C
Sbjct: 1030 SKCDAC 1035



 Score = 91.7 bits (226), Expect = 1e-17
 Identities = 60/219 (27%), Positives = 90/219 (41%), Gaps = 31/219 (14%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRS-QPGGRTPGPTLGTCVPCQCNGHSSL-----CDPE 1432
            +C+C    SG  C  C  GFY L+   P G         C PC CN   ++     C   
Sbjct: 661  QCNCKRHVSGRQCNQCQNGFYNLQELDPDG---------CSPCNCNTSGTVDGDITCHQN 711

Query: 1433 TSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDY 1492
            +  C+ C+ +  G  C+ C  G+  +       C+ C C L  S N F      +     
Sbjct: 712  SGQCK-CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQ----- 765

Query: 1493 RCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPG 1551
                C +  +G  C+ C   + G       +C+ C+CD  GSLP   C+  TG C C+P 
Sbjct: 766  --CECKKEAKGLQCDTCRENFYGLDVT---NCKACDCDTAGSLPGTVCNAKTGQCICKPN 820

Query: 1552 ATGRKCDGCK----HWHAREGWECVFCGDECTGLLLGDL 1586
              GR+C+ C     +      + C+ C  + TG + G L
Sbjct: 821  VEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSL 859



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 64/234 (27%), Positives = 99/234 (42%), Gaps = 31/234 (13%)

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN-----GHSSLCDPETSI 1435
            DC    +G +CE C   F+R      G  P   +  C PC C+       S LCD     
Sbjct: 607  DCEHNTTGRNCELCKDYFFR----QVGADPS-AIDVCKPCDCDTVGTRNGSILCDQIGGQ 661

Query: 1436 CQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC- 1494
            C NC+ H +G  C +C  G+Y + +  P+ C  C C         + S   +G  D  C 
Sbjct: 662  C-NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNC---------NTSGTVDG--DITCH 709

Query: 1495 -----TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCR 1549
                   C     G  C+ C  G+          C+ C+C+ +GS+   C+P +G C C+
Sbjct: 710  QNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECK 769

Query: 1550 PGATGRKCDGCK-HWHAREGWECVFCGDECTGLLLGDL--ARLEQMVMSINLTG 1600
              A G +CD C+ +++  +   C  C  +  G L G +  A+  Q +   N+ G
Sbjct: 770  KEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEG 823



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 54/188 (28%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
            +C+C     GL C+ C   FY           G  +  C  C C+   SL    C+ +T 
Sbjct: 765  QCECKKEAKGLQCDTCRENFY-----------GLDVTNCKACDCDTAGSLPGTVCNAKTG 813

Query: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
             C  C+ +  G  C +C  G + + +     C  C C    + N       + G    +C
Sbjct: 814  QCI-CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTG----QC 868

Query: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPGAT 1553
              C  G  G  C +C P       +    CQ CECD  G+LP   CDP++G C C P   
Sbjct: 869  P-CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQ 927

Query: 1554 GRKCDGCK 1561
            GR+C+ C+
Sbjct: 928  GRRCNQCQ 935



 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 53/192 (27%), Positives = 78/192 (40%), Gaps = 27/192 (14%)

Query: 1388 GLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETS------------- 1434
            GL C+ CLP +     +P  +        C PCQCN HS  C    S             
Sbjct: 546  GLHCDRCLPLY---NDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGG 602

Query: 1435 -ICQNCQHHTAGDFCERCALGYYGIVKGLPND---CQQCACPLISSSNNFSPSCVAEGLD 1490
             +C +C+H+T G  CE C   ++  V   P+    C+ C C  + + N  S  C   G  
Sbjct: 603  GVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNG-SILCDQIG-- 659

Query: 1491 DYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSL--PVPCDPVTGFCTC 1548
              +C  C R   G+ C +C  G+          C  C C+  G++   + C   +G C C
Sbjct: 660  -GQCN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKC 717

Query: 1549 RPGATGRKCDGC 1560
            +    G +CD C
Sbjct: 718  KANVIGLRCDHC 729



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 63/227 (27%), Positives = 84/227 (37%), Gaps = 48/227 (21%)

Query: 303  NKS--RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
            NKS  +C C+    G  C+QC P  H+       F     C+ C C              
Sbjct: 862  NKSTGQCPCKLGVTGLRCNQCEP--HRYNLTIDNF---QHCQMCECDSLG---------- 906

Query: 361  RRNLSLNIRGKYIG--GGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDP 418
                   + G       G C+ C  N  G  C  C  GF+    +SP     C PC C  
Sbjct: 907  ------TLPGTICDPISGQCL-CVPNRQGRRCNQCQPGFY----ISPGNATGCLPCSCHT 955

Query: 419  IGSLNEVCVKDEKHARRGLAPGSCHCK-TGFGGVSCDRCARGYTGYPD----CKACNCSG 473
             G++N +C             G C C+     G  CD+C   Y G+      C+ CNC  
Sbjct: 956  TGAVNHIC---------NSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006

Query: 474  LGSKNEDPCF---GPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDE 517
             G+ NE  C    G C CK+ V G  C  C     +L  +N  GC +
Sbjct: 1007 SGALNET-CHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 79/353 (22%), Positives = 159/353 (45%), Gaps = 39/353 (11%)

Query: 2167 YNNIVVNVKTAVADNLLFYLGS-AKFIDFLAIEMRKGKVSFLWDV-GSGVGRVEYPD--L 2222
            +  I  + +T V + L+ +  S     ++ A++++KG++ FL+D  GS V      D   
Sbjct: 1541 FTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGK 1600

Query: 2223 TIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVG 2282
               D  W+ I+A R    G I++  +    ++I+          G T+  +  N  +F+G
Sbjct: 1601 QYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILN---------GSTV--IGDNTGVFLG 1649

Query: 2283 GLTGK---LKKADAVRVITFTGCMGETYF--DNKPIGLWNFREKEGDCKGCTVSPQVEDS 2337
            GL      L+K   +    F GC+ + +F  +  P  +W   + +   +   V    E  
Sbjct: 1650 GLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGC 1709

Query: 2338 EGTI----QFDGEGYALVSRPIRWYPNIS-TVMFKFRTFSSSALLMYLATRDLRDFMSVE 2392
              ++    QF G G+ L   P  ++  ++  + FKFRT   + LL+++  +D  DF+++E
Sbjct: 1710 PASLNEGAQFLGAGF-LELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAME 1768

Query: 2393 LTDGHI--KVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIA 2450
            L  G +  +++  L      ++   ++ +GKW       I+K+ +     ++   +    
Sbjct: 1769 LKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVI---IKKEGSFISASVNGLMKH--- 1822

Query: 2451 TSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISR 2503
             S SG+     L  +  +Y GG+P  + L    +     + + GC+KD++ +R
Sbjct: 1823 ASESGDQ---PLVVNSPVYVGGIP--QELLNSYQHLCLEQGFGGCMKDVKFTR 1870



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 22/163 (13%)

Query: 1420 CQCNGHSSLCD----PETSICQNCQHHTAGDFCERCALGYYGIVKGLPND------CQQC 1469
            CQC+GH+  CD    P   +C   +  T G  C+RC L  Y        D      C+ C
Sbjct: 518  CQCHGHADNCDTTSQPYRCLCSQ-ESFTEGLHCDRC-LPLYNDKPFRQGDQVYAFNCKPC 575

Query: 1470 ACPLISSSNNFSPSCVAEGLDDYR-----CTACPRGYEGQYCERCAPGY---TGSPGNPG 1521
             C   S S +++ S      + +R     C  C     G+ CE C   +    G+  +  
Sbjct: 576  QCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAI 635

Query: 1522 GSCQECECDPYGSL--PVPCDPVTGFCTCRPGATGRKCDGCKH 1562
              C+ C+CD  G+    + CD + G C C+   +GR+C+ C++
Sbjct: 636  DVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQN 678



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 80/352 (22%), Positives = 146/352 (41%), Gaps = 50/352 (14%)

Query: 2341 IQFDGEGYALVSRPIRWYP---NISTVMFKFRTFSSSALLMYLATR-DLRDFMSVELTDG 2396
            I+F G GY     P   +P   + + +   FRT     L+++ A+  +  ++ +++L  G
Sbjct: 1520 IRFIGNGYCKF--PSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKG 1577

Query: 2397 HIKVSYDLGSGMASVVSNQNH----NDGKWKSFTLSRIQKQANISIVDIDTNQEENIATS 2452
             +   +D       V +  +H    +DGKW      R Q    I++  I T     +  S
Sbjct: 1578 RLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGS 1637

Query: 2453 SS-GNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRT------- 2504
            +  G+N G        ++ GGLP    + ++  PE+  K + GCLKD+   +        
Sbjct: 1638 TVIGDNTG--------VFLGGLPRSYTI-LRKDPEIIQKGFVGCLKDVHFMKNYNPSAIW 1688

Query: 2505 -PYNILSSPDYVGVT---KGCSLENVYTVSFPKPGFVELSPVPIDVGT--EINLSFSTKN 2558
             P +  SS + + V    +GC         F   GF+EL P     G   EI+  F T  
Sbjct: 1689 EPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQ 1748

Query: 2559 ESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTG-ARTMRKIVIRPEPNL 2617
             +G++L               + G  +  + L  G L   L+T  A T   +++      
Sbjct: 1749 LNGLLLF-----------VYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLS--- 1794

Query: 2618 FHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPE 2668
            + +G+ + V +++     +  V+   ++    + +QP+ V   ++VGG P E
Sbjct: 1795 YCNGKWNKVIIKKEGSFISASVNGLMKHASE-SGDQPLVVNSPVYVGGIPQE 1845



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 27/94 (28%), Positives = 39/94 (41%), Gaps = 18/94 (19%)

Query: 1492 YRCTACPRGY-EGQYCERCAPGYTGSPGNPGG-----SCQECECDPYGS---LPVPCDPV 1542
            YRC      + EG +C+RC P Y   P   G      +C+ C+C+ +       +  DP 
Sbjct: 534  YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPF 593

Query: 1543 T--------GFC-TCRPGATGRKCDGCKHWHARE 1567
                     G C  C    TGR C+ CK +  R+
Sbjct: 594  PFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627



 Score = 37.0 bits (84), Expect = 0.31
 Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 11/165 (6%)

Query: 2940 RGTYFDGTGFAKAVGG-FKVGLDLL-VEFEFRTTTTTGVLLGISS--QKMDGMGIEMIDE 2995
            +G  F G G+ K       V  D   ++  FRT    G+++  +S   + +   +++   
Sbjct: 1518 KGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKG 1577

Query: 2996 KLMFHVDNGAG--RFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNP 3053
            +L F  D        T   D G      DG+WH++ A + +   ++T+DG    + +   
Sbjct: 1578 RLYFLFDPQGSPVEVTTTNDHGK--QYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILN 1635

Query: 3054 ASTSADTNDPVFVGGFPDD---LKQFGLTTSIPFRGCIRSLKLTK 3095
             ST    N  VF+GG P     L++        F GC++ +   K
Sbjct: 1636 GSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMK 1680


>gi|219842259 usherin isoform A [Homo sapiens]
          Length = 1546

 Score =  275 bits (704), Expect = 4e-73
 Identities = 171/471 (36%), Positives = 229/471 (48%), Gaps = 52/471 (11%)

Query: 723  VCQ-CPPGYTGSSCESCWPRHRRVNGTIFGGI--CEPCQCF-----GHAESCDDVTGECL 774
            VC  C    TG +CE C     R  G     I  C+PC C        +  CD + G+C 
Sbjct: 604  VCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC- 662

Query: 775  NCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDG 834
            NCK H  G  C++C  GFY        + C PC C  +   +    TCH +      C  
Sbjct: 663  NCKRHVSGRQCNQCQNGFYNLQELDP-DGCSPCNCNTSGTVDG-DITCHQNSGQ---CK- 716

Query: 835  CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTT 894
            C     G RC+ C  G+    S     C+PCQCN  L  S+   C+  SG C  CK    
Sbjct: 717  CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCN--LHGSVNKFCNPHSGQCE-CKKEAK 773

Query: 895  GRYCELCADGYFGDAVDAKNCQPCRCNAGGSF-SEVCHSQTGQCECRANVQGQRCDKCKA 953
            G  C+ C + ++G  +D  NC+ C C+  GS    VC+++TGQC C+ NV+G++C+KC  
Sbjct: 774  GLQCDTCRENFYG--LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLE 831

Query: 954  GTFGLQSARG--CVPCNCNSFGS--KSFDCEES-GQCWCQPGVTGKKCDRCA-HGYF--- 1004
            G F L+      C+PCNC+  G+   S  C +S GQC C+ GVTG +C++C  H Y    
Sbjct: 832  GNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTI 891

Query: 1005 -NFQEGGCTACECSHLGNN----CDPKTGRCICPPNTIGEKCSKCAPNTW-GHSITTGCK 1058
             NFQ   C  CEC  LG      CDP +G+C+C PN  G +C++C P  +      TGC 
Sbjct: 892  DNFQH--CQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCL 949

Query: 1059 ACNCSTVGSLDFQCNVNTGQCNCHP-KFSGAKCTECSRGHWNYP----RCNLCDCFLPGT 1113
             C+C T G+++  CN  TGQC C     +G +C +C   ++ +     RC  C+C L G 
Sbjct: 950  PCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGA 1009

Query: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCS 1164
               TC   T         GQC CK  V G  CD C P    LD  N LGCS
Sbjct: 1010 LNETCHLVT---------GQCFCKQFVTGSKCDACVPSASHLDVNNLLGCS 1051



 Score =  273 bits (699), Expect = 1e-72
 Identities = 154/456 (33%), Positives = 218/456 (47%), Gaps = 58/456 (12%)

Query: 757  CQCFGHAESCDDVTGECLNC----KDHTGGPYCDKCLPGFYGEPTKGTSE----DCQPCA 808
            CQC GHA++C D T +   C    +  T G +CD+CLP +  +P +   +    +C+PC 
Sbjct: 518  CQCHGHADNC-DTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQ 576

Query: 809  CPLNIPSNNFSPTCHLDRSL-----------GLICDGCPVGYTGPRCERCAEGYFGQPSV 857
            C      N+ S +CH + S+           G +CD C    TG  CE C + +F Q   
Sbjct: 577  C------NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGA 630

Query: 858  PGGS---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG-DAVDAK 913
               +   C+PC C+     +    CD + G C  CK   +GR C  C +G++    +D  
Sbjct: 631  DPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQELDPD 689

Query: 914  NCQPCRCNAGGSFSE--VCHSQTGQCECRANVQGQRCDKCKAGTFGLQSAR--GCVPCNC 969
             C PC CN  G+      CH  +GQC+C+ANV G RCD C  G   L+S    GC PC C
Sbjct: 690  GCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQC 749

Query: 970  NSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACEC----SHLGNNCD 1024
            N  GS +  C   SGQC C+    G +CD C   ++      C AC+C    S  G  C+
Sbjct: 750  NLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCN 809

Query: 1025 PKTGRCICPPNTIGEKCSKCAPNTW--GHSITTGCKACNCSTVGSLD--FQCNVNTGQCN 1080
             KTG+CIC PN  G +C+KC    +    + +  C  CNC   G+++    CN +TGQC 
Sbjct: 810  AKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCP 869

Query: 1081 CHPKFSGAKCTECSRGHW-----NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT 1135
            C    +G +C +C    +     N+  C +C+C   GT   T         C   +GQC 
Sbjct: 870  CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI--------CDPISGQCL 921

Query: 1136 CKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGT 1171
            C  N +G  C++C+PG F +   N  GC  C C  T
Sbjct: 922  CVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCHTT 956



 Score =  194 bits (492), Expect = 1e-48
 Identities = 138/449 (30%), Positives = 205/449 (45%), Gaps = 53/449 (11%)

Query: 92  NPNQRHPITNAIDGK-NTWWQSPSIKNGIEYHY-VTITLDLQQ-VFQIAYVIVKAANSPR 148
           NP + HP++   D    T W S    N  + +  VTI++DL+   +Q+ Y+I++   SP+
Sbjct: 336 NP-EAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFF-SPQ 393

Query: 149 PGNWILERSLDD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIH 207
           P    ++R  ++ ++++ WQY A     C      +         K D V C    S   
Sbjct: 394 PTEIRIQRKKENSLDWEDWQYFA---RNC----GAFGMKNNGDLEKPDSVNCLQL-SNFT 445

Query: 208 PLENGEIHISLI----NGRPSADD--PSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261
           P   G +  S++    N RP  ++   +P L EF  A  IR  F          +   H+
Sbjct: 446 PYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHR 505

Query: 262 DPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQC 321
                        YY+V +I++ G C C+GHA  C       +  C  E  T G  CD+C
Sbjct: 506 -------------YYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRC 552

Query: 322 CPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381
            P ++ KP+R G  +    C+ C C+  ++ C+Y+ +V       + RG   GGGVC +C
Sbjct: 553 LPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFE-HFRG---GGGVCDDC 608

Query: 382 TQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGS 441
             NT G NCE C D FFR  G  P+    C+PC CD +G+ N   + D+         G 
Sbjct: 609 EHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQ-------IGGQ 661

Query: 442 CHCKTGFGGVSCDRCARGYTGY----PD-CKACNCSGLGSKNED-PCF---GPCICKENV 492
           C+CK    G  C++C  G+       PD C  CNC+  G+ + D  C    G C CK NV
Sbjct: 662 CNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANV 721

Query: 493 EGGDCSRCKSGFFNLQEDNWKGCDECFCS 521
            G  C  C  GF  L+  N  GC+ C C+
Sbjct: 722 IGLRCDHCNFGFKFLRSFNDVGCEPCQCN 750



 Score =  181 bits (458), Expect = 1e-44
 Identities = 115/356 (32%), Positives = 165/356 (46%), Gaps = 66/356 (18%)

Query: 865  CQCNDNLDFSIPGSCDSLSGS--CLICKPG-TTGRYCELCADGYF------GDAVDAKNC 915
            CQC+ + D     +CD+ S    CL  +   T G +C+ C   Y       GD V A NC
Sbjct: 518  CQCHGHAD-----NCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNC 572

Query: 916  QPCRCNAGGSFSEVCHSQT--------------GQCE-CRANVQGQRCDKCKAGTFGLQS 960
            +PC+CN   S S+ CH                 G C+ C  N  G+ C+ CK   F    
Sbjct: 573  KPCQCN---SHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVG 629

Query: 961  ARG-----CVPCNCNSFGSK--SFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQE---G 1009
            A       C PC+C++ G++  S  C++  GQC C+  V+G++C++C +G++N QE    
Sbjct: 630  ADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPD 689

Query: 1010 GCTACECSHLGN-----NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSIT-----TGCKA 1059
            GC+ C C+  G       C   +G+C C  N IG +C  C    +G          GC+ 
Sbjct: 690  GCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHC---NFGFKFLRSFNDVGCEP 746

Query: 1060 CNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHW--NYPRCNLCDCFLPGTDATT 1117
            C C+  GS++  CN ++GQC C  +  G +C  C    +  +   C  CDC   G+   T
Sbjct: 747  CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGT 806

Query: 1118 CDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTT 1173
                     C+ +TGQC CK NVEG  C++C  G F L   N   C  C C  T T
Sbjct: 807  V--------CNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGT 854



 Score =  124 bits (312), Expect = 1e-27
 Identities = 86/289 (29%), Positives = 122/289 (42%), Gaps = 39/289 (13%)

Query: 692  FGMDAIFRLSSVNLESAVSYPTDGSIA-AAVEVCQCPPGYTGSSCESCWPR--HRRVNGT 748
            +G+D +    + + ++A S P  G++  A    C C P   G  C  C     + R N +
Sbjct: 785  YGLD-VTNCKACDCDTAGSLP--GTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNS 841

Query: 749  IFGGICEPCQC-----FGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED 803
                +C PC C        +  C+  TG+C  CK    G  C++C P  Y   T    + 
Sbjct: 842  F---LCLPCNCDKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQCEPHRYNL-TIDNFQH 896

Query: 804  CQPCACPLNIPSNNFSPTCHLDRSLGLICDG------CPVGYTGPRCERCAEGYFGQPSV 857
            CQ C C              L    G ICD       C     G RC +C  G++  P  
Sbjct: 897  CQMCECD------------SLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944

Query: 858  PGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQP 917
              G C PC C+     ++   C+SL+G C+       G+ C+ C D YFG       CQP
Sbjct: 945  ATG-CLPCSCHTT--GAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQP 1001

Query: 918  CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKC--KAGTFGLQSARGC 964
            C C+  G+ +E CH  TGQC C+  V G +CD C   A    + +  GC
Sbjct: 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050



 Score =  106 bits (264), Expect = 4e-22
 Identities = 70/223 (31%), Positives = 94/223 (42%), Gaps = 42/223 (18%)

Query: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
           +C C+ +  G  C+QC  GF+         L    C  CNC                N S
Sbjct: 661 QCNCKRHVSGRQCNQCQNGFYNLQE-----LDPDGCSPCNC----------------NTS 699

Query: 366 LNIRGK---YIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSL 422
             + G    +   G C  C  N  G+ C+ C  GF   K +       C+PC C+  GS+
Sbjct: 700 GTVDGDITCHQNSGQC-KCKANVIGLRCDHCNFGF---KFLRSFNDVGCEPCQCNLHGSV 755

Query: 423 NEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP--DCKACNCSGLGSKNED 480
           N+ C     H+      G C CK    G+ CD C   + G    +CKAC+C   GS    
Sbjct: 756 NKFC---NPHS------GQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGT 806

Query: 481 PC---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
            C    G CICK NVEG  C++C  G F L+++N   C  C C
Sbjct: 807 VCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 70/251 (27%), Positives = 102/251 (40%), Gaps = 51/251 (20%)

Query: 296 CPLDPATNK------SRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGK 349
           C L  + NK       +CEC+    G  CD C   F+         L  T C+AC+C   
Sbjct: 749 CNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYG--------LDVTNCKACDC--- 797

Query: 350 AEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPR 409
                 D   +      N +      G CI C  N  G  C  C +G F    +  N   
Sbjct: 798 ------DTAGSLPGTVCNAKT-----GQCI-CKPNVEGRQCNKCLEGNFY---LRQNNSF 842

Query: 410 PCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARG-----YTGYP 464
            C PC+CD  G++N   + ++       + G C CK G  G+ C++C           + 
Sbjct: 843 LCLPCNCDKTGTINGSLLCNK-------STGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895

Query: 465 DCKACNCSGLGSKNE---DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC- 520
            C+ C C  LG+      DP  G C+C  N +G  C++C+ GF+ +   N  GC  C C 
Sbjct: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCH 954

Query: 521 --SGVSNRCQS 529
               V++ C S
Sbjct: 955 TTGAVNHICNS 965



 Score = 92.0 bits (227), Expect = 8e-18
 Identities = 58/186 (31%), Positives = 75/186 (40%), Gaps = 21/186 (11%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
            +C C LG +GL C  C P  Y L               C  C+C+   +L    CDP + 
Sbjct: 867  QCPCKLGVTGLRCNQCEPHRYNLTID--------NFQHCQMCECDSLGTLPGTICDPISG 918

Query: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
             C  C  +  G  C +C  G+Y I  G    C  C+C    + N+   S   +      C
Sbjct: 919  QCL-CVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQ------C 970

Query: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATG 1554
                    GQ C++C   Y G     G  CQ C C   G+L   C  VTG C C+   TG
Sbjct: 971  VCQDASIAGQRCDQCKDHYFGFDPQTG-RCQPCNCHLSGALNETCHLVTGQCFCKQFVTG 1029

Query: 1555 RKCDGC 1560
             KCD C
Sbjct: 1030 SKCDAC 1035



 Score = 91.7 bits (226), Expect = 1e-17
 Identities = 60/219 (27%), Positives = 90/219 (41%), Gaps = 31/219 (14%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRS-QPGGRTPGPTLGTCVPCQCNGHSSL-----CDPE 1432
            +C+C    SG  C  C  GFY L+   P G         C PC CN   ++     C   
Sbjct: 661  QCNCKRHVSGRQCNQCQNGFYNLQELDPDG---------CSPCNCNTSGTVDGDITCHQN 711

Query: 1433 TSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDY 1492
            +  C+ C+ +  G  C+ C  G+  +       C+ C C L  S N F      +     
Sbjct: 712  SGQCK-CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQ----- 765

Query: 1493 RCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPG 1551
                C +  +G  C+ C   + G       +C+ C+CD  GSLP   C+  TG C C+P 
Sbjct: 766  --CECKKEAKGLQCDTCRENFYGLDVT---NCKACDCDTAGSLPGTVCNAKTGQCICKPN 820

Query: 1552 ATGRKCDGCK----HWHAREGWECVFCGDECTGLLLGDL 1586
              GR+C+ C     +      + C+ C  + TG + G L
Sbjct: 821  VEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSL 859



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 64/234 (27%), Positives = 99/234 (42%), Gaps = 31/234 (13%)

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN-----GHSSLCDPETSI 1435
            DC    +G +CE C   F+R      G  P   +  C PC C+       S LCD     
Sbjct: 607  DCEHNTTGRNCELCKDYFFR----QVGADPS-AIDVCKPCDCDTVGTRNGSILCDQIGGQ 661

Query: 1436 CQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC- 1494
            C NC+ H +G  C +C  G+Y + +  P+ C  C C         + S   +G  D  C 
Sbjct: 662  C-NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNC---------NTSGTVDG--DITCH 709

Query: 1495 -----TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCR 1549
                   C     G  C+ C  G+          C+ C+C+ +GS+   C+P +G C C+
Sbjct: 710  QNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECK 769

Query: 1550 PGATGRKCDGCK-HWHAREGWECVFCGDECTGLLLGDL--ARLEQMVMSINLTG 1600
              A G +CD C+ +++  +   C  C  +  G L G +  A+  Q +   N+ G
Sbjct: 770  KEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEG 823



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 54/188 (28%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
            +C+C     GL C+ C   FY           G  +  C  C C+   SL    C+ +T 
Sbjct: 765  QCECKKEAKGLQCDTCRENFY-----------GLDVTNCKACDCDTAGSLPGTVCNAKTG 813

Query: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
             C  C+ +  G  C +C  G + + +     C  C C    + N       + G    +C
Sbjct: 814  QCI-CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTG----QC 868

Query: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPGAT 1553
              C  G  G  C +C P       +    CQ CECD  G+LP   CDP++G C C P   
Sbjct: 869  P-CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQ 927

Query: 1554 GRKCDGCK 1561
            GR+C+ C+
Sbjct: 928  GRRCNQCQ 935



 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 53/192 (27%), Positives = 78/192 (40%), Gaps = 27/192 (14%)

Query: 1388 GLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETS------------- 1434
            GL C+ CLP +     +P  +        C PCQCN HS  C    S             
Sbjct: 546  GLHCDRCLPLY---NDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGG 602

Query: 1435 -ICQNCQHHTAGDFCERCALGYYGIVKGLPND---CQQCACPLISSSNNFSPSCVAEGLD 1490
             +C +C+H+T G  CE C   ++  V   P+    C+ C C  + + N  S  C   G  
Sbjct: 603  GVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNG-SILCDQIG-- 659

Query: 1491 DYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSL--PVPCDPVTGFCTC 1548
              +C  C R   G+ C +C  G+          C  C C+  G++   + C   +G C C
Sbjct: 660  -GQCN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKC 717

Query: 1549 RPGATGRKCDGC 1560
            +    G +CD C
Sbjct: 718  KANVIGLRCDHC 729



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 63/227 (27%), Positives = 84/227 (37%), Gaps = 48/227 (21%)

Query: 303  NKS--RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
            NKS  +C C+    G  C+QC P  H+       F     C+ C C              
Sbjct: 862  NKSTGQCPCKLGVTGLRCNQCEP--HRYNLTIDNF---QHCQMCECDSLG---------- 906

Query: 361  RRNLSLNIRGKYIG--GGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDP 418
                   + G       G C+ C  N  G  C  C  GF+    +SP     C PC C  
Sbjct: 907  ------TLPGTICDPISGQCL-CVPNRQGRRCNQCQPGFY----ISPGNATGCLPCSCHT 955

Query: 419  IGSLNEVCVKDEKHARRGLAPGSCHCK-TGFGGVSCDRCARGYTGYPD----CKACNCSG 473
             G++N +C             G C C+     G  CD+C   Y G+      C+ CNC  
Sbjct: 956  TGAVNHIC---------NSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006

Query: 474  LGSKNEDPCF---GPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDE 517
             G+ NE  C    G C CK+ V G  C  C     +L  +N  GC +
Sbjct: 1007 SGALNET-CHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 22/163 (13%)

Query: 1420 CQCNGHSSLCD----PETSICQNCQHHTAGDFCERCALGYYGIVKGLPND------CQQC 1469
            CQC+GH+  CD    P   +C   +  T G  C+RC L  Y        D      C+ C
Sbjct: 518  CQCHGHADNCDTTSQPYRCLCSQ-ESFTEGLHCDRC-LPLYNDKPFRQGDQVYAFNCKPC 575

Query: 1470 ACPLISSSNNFSPSCVAEGLDDYR-----CTACPRGYEGQYCERCAPGY---TGSPGNPG 1521
             C   S S +++ S      + +R     C  C     G+ CE C   +    G+  +  
Sbjct: 576  QCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAI 635

Query: 1522 GSCQECECDPYGSL--PVPCDPVTGFCTCRPGATGRKCDGCKH 1562
              C+ C+CD  G+    + CD + G C C+   +GR+C+ C++
Sbjct: 636  DVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQN 678



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 27/94 (28%), Positives = 39/94 (41%), Gaps = 18/94 (19%)

Query: 1492 YRCTACPRGY-EGQYCERCAPGYTGSPGNPGG-----SCQECECDPYGS---LPVPCDPV 1542
            YRC      + EG +C+RC P Y   P   G      +C+ C+C+ +       +  DP 
Sbjct: 534  YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPF 593

Query: 1543 T--------GFC-TCRPGATGRKCDGCKHWHARE 1567
                     G C  C    TGR C+ CK +  R+
Sbjct: 594  PFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627


>gi|143770880 laminin, beta 4 [Homo sapiens]
          Length = 1761

 Score =  262 bits (670), Expect = 3e-69
 Identities = 129/344 (37%), Positives = 182/344 (52%), Gaps = 28/344 (8%)

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGP 783
            C C    +G  C+ C      + G      C PC C   AE CD  TG C NC   T G 
Sbjct: 836  CPCHGEVSGRRCDRC------LAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGR 889

Query: 784  YCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNN-FSPTCHLDR-SLGLICDGCPVGYTG 841
             C++C+ G+YG P+ G  + C+PC CP +  SN  F+ +C+ +  S  +IC+ C  GYTG
Sbjct: 890  NCERCIDGYYGNPSSG--QPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICN-CLQGYTG 946

Query: 842  PRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELC 901
             +C  C+ G++G P + G  CQPC CN+N+D + P SC  ++G CL C   T G  C+LC
Sbjct: 947  TQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQLC 1006

Query: 902  ADGYFGDAVDAKNCQPCRCNAG---------GSFSEVCHSQTGQCECRANVQGQRCDKCK 952
              G++G A++ + C+ C C+A          G  + +C   TG C C  NV G  CD+C 
Sbjct: 1007 KPGHYGSALN-QTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCA 1065

Query: 953  AGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGC 1011
             G + L   RGC  C+C+   S+S  C++ +GQC C+ G  GK+C  C   Y+    G C
Sbjct: 1066 DGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRC 1125

Query: 1012 TACECSHLGNN---CDPKTGRCICPPNTIGEKCSKCAPNTWGHS 1052
              C+C+  G     CDP TG C C     G++C +CA    GHS
Sbjct: 1126 IPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCAR---GHS 1166



 Score =  224 bits (570), Expect = 1e-57
 Identities = 150/487 (30%), Positives = 202/487 (41%), Gaps = 85/487 (17%)

Query: 757  CQCFGHAE---SCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNI 813
            C+C        SC  + G+C  CK    G  CD+C  G Y     G    C PC C    
Sbjct: 769  CKCHPQGSVGSSCSRLGGQC-QCKPLVVGRCCDRCSTGSYDLGHHG----CHPCHC---- 819

Query: 814  PSNNFSPTCHLDRSLGLICDG------CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQC 867
                     H   S   +CD       C    +G RC+RC  GYFG PS     C PC C
Sbjct: 820  ---------HPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS-----CHPCPC 865

Query: 868  NDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRC----NAG 923
            N   +      CD  +GSC  C   TTGR CE C DGY+G+    + C+PC C    ++ 
Sbjct: 866  NRFAEL-----CDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSN 920

Query: 924  GSFSEVCHSQTGQ----CECRANVQGQRCDKCKAGTFGLQSARG--CVPCNCNSF--GSK 975
              F+  C+         C C     G +C +C  G +G     G  C PC CN+    + 
Sbjct: 921  QYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTD 980

Query: 976  SFDCEE-SGQCW-CQPGVTGKKCDRCAHGYFNFQ-EGGCTACECSHLGNN---------- 1022
               C   +G+C  C     G  C  C  G++       C  C C   G +          
Sbjct: 981  PESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGA 1040

Query: 1023 --CDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCN 1080
              CDP TG C C PN  G  C +CA   W      GC++C+C    S    C+  TGQC 
Sbjct: 1041 CLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCP 1100

Query: 1081 CHPKFSGAKCTECSRGHWNYP--RCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKV 1138
            C   + G +C+EC   ++  P  RC  CDC   GT    CD +         TG C C+ 
Sbjct: 1101 CKLGYGGKRCSECQENYYGDPPGRCIPCDCNRAGTQKPICDPD---------TGMCRCRE 1151

Query: 1139 NVEGIHCDRCRPGKFGLDAKNPLGCSSCY-CFG----TTTQCSEA-KGLIRTWVTLKAEQ 1192
             V G  CDRC  G     ++    C  C+ CF     T +  S+A +GL+R    ++ ++
Sbjct: 1152 GVSGQRCDRCARG----HSQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANMEDKR 1207

Query: 1193 TILPLVD 1199
              LP+ +
Sbjct: 1208 ETLPVCE 1214



 Score =  216 bits (551), Expect = 2e-55
 Identities = 147/518 (28%), Positives = 240/518 (46%), Gaps = 68/518 (13%)

Query: 44  LNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNS-----SNPNQRHP 98
           L +  N  +  ++TCG    + YC ++ ++ G+     +C IC+          PN  H 
Sbjct: 35  LLVGRNTQLMASSTCGLSRAQKYC-ILSYLEGEQ----KCFICDSRFPYDPYDQPNS-HT 88

Query: 99  ITNAI-----DGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWI 153
           I N I     D +  WWQS   +NG+++  V+I LDL+ +F+ +++I+    + RP   +
Sbjct: 89  IENVIVSFEPDREKKWWQS---ENGLDH--VSIRLDLEALFRFSHLIL-TFKTFRPAAML 142

Query: 154 LERSLD-DVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENG 212
           +ERS D    +K ++Y A    +C T +   P           +++C S YS I P   G
Sbjct: 143 VERSTDYGHNWKVFKYFA---KDCATSF---PNITSGQAQGVGDIVCDSKYSDIEPSTGG 196

Query: 213 EIHISLINGRPSADDP-SPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVT 271
           E+ + +++     ++P SP + +  +   +R+ F ++ TL   L+     D  +      
Sbjct: 197 EVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDSLD------ 250

Query: 272 RRYYYSVKDISVGGMCICYGHARAC-PLD---------PATNKSRCECEHNTCGDSCDQC 321
            +YYY++ ++ V G C C GHA  C P+          P     +C C+HNT G +C++C
Sbjct: 251 -KYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERC 309

Query: 322 CPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381
              F   PWR    L    C +C+C+  +  C++D       ++  +    + GGVC +C
Sbjct: 310 KDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFD-------MTTYLASGGLSGGVCEDC 362

Query: 382 TQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLN-EVCVKDEKHARRGLAPG 440
             NT G +C+ C   F+R    + + P  C PC CDP G+++  +CV     A  G   G
Sbjct: 363 QHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPA-LGSVAG 421

Query: 441 SCHCKTGFGGVSCDRCARGYTGYP-----DCKACNCSGLGSKNEDPC---FGPCICKENV 492
            C CK    G  CD+C   + G        C+ C+C+ LGS     C    G C+C   V
Sbjct: 422 QCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYV 481

Query: 493 EGGDCSRCKSGFFNLQEDNWKGCDECFC---SGVSNRC 527
            G  C  C  G++ L  ++  GC  C C      SN C
Sbjct: 482 TGAHCEECTVGYWGL-GNHLHGCSPCDCDIGGAYSNVC 518



 Score =  164 bits (415), Expect = 1e-39
 Identities = 94/259 (36%), Positives = 119/259 (45%), Gaps = 32/259 (12%)

Query: 723  VCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGH-----AESCDDVTGECLNCK 777
            +C C  GYTG+ C  C       N  I G  C+PC C  +      ESC  VTGECL C 
Sbjct: 937  ICNCLQGYTGTQCGECSTGFYG-NPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCL 995

Query: 778  DHTGGPYCDKCLPGFYGEPTKGTSEDCQPCAC------PLNIPSNNFSPTCHLDRSLGLI 831
             +T G  C  C PG YG      ++ C+ C+C      P+  P    +  C        +
Sbjct: 996  HNTQGANCQLCKPGHYG---SALNQTCRRCSCHASGVSPMECPPGGGACLC------DPV 1046

Query: 832  CDGCPV--GYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLIC 889
               CP     TG  C+RCA+GY+    VPG  CQ C C+     S    CD L+G C  C
Sbjct: 1047 TGACPCLPNVTGLACDRCADGYWN--LVPGRGCQSCDCDPRTSQS--SHCDQLTGQC-PC 1101

Query: 890  KPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCD 949
            K G  G+ C  C + Y+GD      C PC CN  G+   +C   TG C CR  V GQRCD
Sbjct: 1102 KLGYGGKRCSECQENYYGD--PPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCD 1159

Query: 950  KCKAGTFGLQSARGCVPCN 968
            +C  G    Q    C+ C+
Sbjct: 1160 RCARG--HSQEFPTCLQCH 1176



 Score =  144 bits (364), Expect = 1e-33
 Identities = 83/254 (32%), Positives = 117/254 (46%), Gaps = 25/254 (9%)

Query: 724 CQCPPGYTGSSCESCWPRHR----RVNGTIFGGICEPCQCFGHAESCD-DVT-------- 770
           C C     G +CE C    +    R    +    C  C C  H+  C  D+T        
Sbjct: 295 CVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGL 354

Query: 771 --GECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED--CQPCACPLNIPSNNFSPTCHLDR 826
             G C +C+ +T G +CD+C P FY +P K  S+   C PC C  +   +      H D 
Sbjct: 355 SGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDP 414

Query: 827 SLGLICDGC--PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCND--NLDFSIPGSCDSL 882
           +LG +   C       G +C++C   ++G  +     CQPC CN   +L F    +CD  
Sbjct: 415 ALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFL---TCDVD 471

Query: 883 SGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRAN 942
           +G CL C    TG +CE C  GY+G       C PC C+ GG++S VC  + GQCECR +
Sbjct: 472 TGQCL-CLSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPH 530

Query: 943 VQGQRCDKCKAGTF 956
           V G+ C +   G F
Sbjct: 531 VTGRSCSEPAPGYF 544



 Score =  138 bits (348), Expect = 7e-32
 Identities = 94/287 (32%), Positives = 126/287 (43%), Gaps = 58/287 (20%)

Query: 912  AKNCQPCRCNAGGSFSE--VCHSQTGQCECRANVQGQRCDKCK--------AGTFGLQSA 961
            A  C+P +   G  FS   + H   GQC C+ N  G  C++CK             LQ  
Sbjct: 271  ASECRPMQKMRGDVFSPPGMVH---GQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQD- 326

Query: 962  RGCVPCNCNSFGSKS-FDCE--------ESGQCW-CQPGVTGKKCDRCAHGYFN------ 1005
              C  C+CNS  S+  FD            G C  CQ    G+ CDRC   ++       
Sbjct: 327  NACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTI 386

Query: 1006 FQEGGCTACECSHLG--------NNCDPK----TGRCICPPNTIGEKCSKCAPNTWGHSI 1053
                 C  CEC   G        ++ DP      G+C+C  N  G KC +C PN +G S 
Sbjct: 387  SDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSA 446

Query: 1054 TT--GCKACNCSTVGSLDF-QCNVNTGQCNCHPKFSGAKCTECSRGHWNYPR----CNLC 1106
            T   GC+ C+C+ +GSL F  C+V+TGQC C    +GA C EC+ G+W        C+ C
Sbjct: 447  TDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPC 506

Query: 1107 DCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKF 1153
            DC + G  +  C         S + GQC C+ +V G  C    PG F
Sbjct: 507  DCDIGGAYSNVC---------SPKNGQCECRPHVTGRSCSEPAPGYF 544



 Score =  136 bits (343), Expect = 3e-31
 Identities = 199/875 (22%), Positives = 327/875 (37%), Gaps = 173/875 (19%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPE-----TS 1434
            C+C  GY+G  C  C  GFY          P  +   C PC CN +  + DPE     T 
Sbjct: 938  CNCLQGYTGTQCGECSTGFYG--------NPRISGAPCQPCACNNNIDVTDPESCSRVTG 989

Query: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
             C  C H+T G  C+ C  G+YG    L   C++C+C     S    P      L D   
Sbjct: 990  ECLRCLHNTQGANCQLCKPGHYG--SALNQTCRRCSCHASGVSPMECPPGGGACLCDPVT 1047

Query: 1495 TACP--RGYEGQYCERCAPGYTGSPGNPGGSCQECECDP--------------------- 1531
             ACP      G  C+RCA GY      PG  CQ C+CDP                     
Sbjct: 1048 GACPCLPNVTGLACDRCADGYWNLV--PGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGY 1105

Query: 1532 ------------YGSLP---VPCD------------PVTGFCTCRPGATGRKCDGCKHWH 1564
                        YG  P   +PCD            P TG C CR G +G++CD C   H
Sbjct: 1106 GGKRCSECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165

Query: 1565 ARE---GWECVFCGDECTGLL------LGDLARLEQMVMSINLTGPL-PAPYKMLYG-LE 1613
            ++E     +C  C D+    +      +  L RL   +     T P+  A +K L G + 
Sbjct: 1166 SQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANMEDKRETLPVCEADFKDLRGNVS 1225

Query: 1614 NMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNT 1673
             + + LKH + P       ++    ++   + ++NE L    K   + +      ER   
Sbjct: 1226 EIERILKHPVFPS-GKFLKVKDYHDSVRRQIMQLNEQL----KAVYEFQDLKDTIERAKN 1280

Query: 1674 RAKSLGEFIKE-------------------------LARDAE-AVNEKAIKLNETLGTRD 1707
             A  L E ++E                         ++  AE  +NE +  +N +  TR+
Sbjct: 1281 EADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHISSSAEKKINETSSTINTSANTRN 1340

Query: 1708 EAF----------ERNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALL---KKV 1754
            +              +LE L++     I+ L  K       +    L    AL    K  
Sbjct: 1341 DLLTILDTLTSKGNLSLERLKQIKIPDIQILNEKVCGDPGNVPCVPLPCGGALCTGRKGH 1400

Query: 1755 KKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTAL 1814
            +K  G     +  +  +  +K  + K+ + +    +R   ++I   +    V++ N   L
Sbjct: 1401 RKCRGPGCHGSLTLSTNALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQL 1460

Query: 1815 EKK----KEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEEL 1870
             +K    +   +S +  I   +K+  + L E N   ++I  + + V DI   +P  S+ L
Sbjct: 1461 REKLGNIRNQSDSEEENINLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIP--SQNL 1518

Query: 1871 NDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSN 1930
             D++      +K +K  +      +   +LN+ +       D A+ +   A AA KA +N
Sbjct: 1519 TDEL------VKIQKHMQLCEDYRTDENRLNEEA-------DGAQKLLVKAKAAEKA-AN 1564

Query: 1931 IKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKE 1990
            I   +D+     ++A+     A    T                  ++     K+  +V +
Sbjct: 1565 ILLNLDKTLNQLQQAQITQGRANSTIT------------------QLTANITKIKKNVLQ 1606

Query: 1991 NEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKD 2050
             E+    +K+ +E A  R+G     L D L  L         KLQ  +D A  A   A+ 
Sbjct: 1607 AENQTREMKSELELAKQRSG-----LEDGLSLLQ-------TKLQRHQDHAVNAKVQAES 1654

Query: 2051 VLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIAD-ADATVKNLEQEADRL 2109
               Q   L +    LKK Y  L    + T    +   K K + D A+    + E +  R+
Sbjct: 1655 AQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRI 1714

Query: 2110 IDKLKPIKELEDNLKKNISEIKELINQARKQANSI 2144
             D  + I++L  + +    +++ L +Q     N I
Sbjct: 1715 TDLERKIQDLNLSRQAKADQLRILEDQVVAIKNEI 1749



 Score =  135 bits (341), Expect = 5e-31
 Identities = 86/282 (30%), Positives = 122/282 (43%), Gaps = 50/282 (17%)

Query: 862  CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDA-------VDAKN 914
            C+P Q      FS PG    + G C +C+  T G  CE C D +F DA       +    
Sbjct: 274  CRPMQKMRGDVFSPPGM---VHGQC-VCQHNTDGPNCERCKD-FFQDAPWRPAADLQDNA 328

Query: 915  CQPCRCNAGGSFSEVCHSQT-----------GQCE-CRANVQGQRCDKCKAGTFG----- 957
            C+ C CN   S S  CH              G CE C+ N +GQ CD+C+   +      
Sbjct: 329  CRSCSCN---SHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKT 385

Query: 958  LQSARGCVPCNCNSFGSKSFDC----------EESGQCWCQPGVTGKKCDRCAHGYFNFQ 1007
            +     C+PC C+  G+ S               +GQC C+  V G KCD+C   ++   
Sbjct: 386  ISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLS 445

Query: 1008 EG---GCTACECSHLGN----NCDPKTGRCICPPNTIGEKCSKCAPNTWG-HSITTGCKA 1059
                 GC  C+C+ LG+     CD  TG+C+C     G  C +C    WG  +   GC  
Sbjct: 446  ATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSP 505

Query: 1060 CNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYP 1101
            C+C   G+    C+   GQC C P  +G  C+E + G++  P
Sbjct: 506  CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAP 547



 Score =  118 bits (296), Expect = 8e-26
 Identities = 74/210 (35%), Positives = 91/210 (43%), Gaps = 22/210 (10%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            +C C    SG  C+ CL G++   S             C PC CN  + LCDPET  C N
Sbjct: 835  QCPCHGEVSGRRCDRCLAGYFGFPS-------------CHPCPCNRFAELCDPETGSCFN 881

Query: 1439 CQHHTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNN-FSPSCVAEGLDDYRCTA 1496
            C   T G  CERC  GYYG    G P  C+ C CP   SSN  F+ SC            
Sbjct: 882  CGGFTTGRNCERCIDGYYGNPSSGQP--CRPCLCPDDPSSNQYFAHSCYQNLWSSDVICN 939

Query: 1497 CPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSL--PVPCDPVTGFC-TCRPGAT 1553
            C +GY G  C  C+ G+ G+P   G  CQ C C+    +  P  C  VTG C  C     
Sbjct: 940  CLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQ 999

Query: 1554 GRKCDGCK--HWHAREGWECVFCGDECTGL 1581
            G  C  CK  H+ +     C  C    +G+
Sbjct: 1000 GANCQLCKPGHYGSALNQTCRRCSCHASGV 1029



 Score =  105 bits (263), Expect = 5e-22
 Identities = 69/213 (32%), Positives = 91/213 (42%), Gaps = 22/213 (10%)

Query: 1366 RGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGH 1425
            RG   +PP  +  +C C     G +CE C   F     +P           C  C CN H
Sbjct: 281  RGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQD---NACRSCSCNSH 337

Query: 1426 SSLCDPETS-----------ICQNCQHHTAGDFCERC-ALGYYGIVKGL--PNDCQQCAC 1471
            SS C  + +           +C++CQH+T G  C+RC  L Y   +K +  P  C  C C
Sbjct: 338  SSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCEC 397

Query: 1472 P---LISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECE 1528
                 IS     S S  A G    +C  C    EG  C++C P + G        CQ C+
Sbjct: 398  DPDGTISGGICVSHSDPALGSVAGQC-LCKENVEGAKCDQCKPNHYGLSATDPLGCQPCD 456

Query: 1529 CDPYGSLP-VPCDPVTGFCTCRPGATGRKCDGC 1560
            C+P GSLP + CD  TG C C    TG  C+ C
Sbjct: 457  CNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEEC 489



 Score =  100 bits (250), Expect = 2e-20
 Identities = 67/210 (31%), Positives = 86/210 (40%), Gaps = 54/210 (25%)

Query: 309  CEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAE---ECYYDENVARRNLS 365
            C HNT G +C  C PG +      G+ L +T C  C+CH       EC            
Sbjct: 994  CLHNTQGANCQLCKPGHY------GSALNQT-CRRCSCHASGVSPMECPP---------- 1036

Query: 366  LNIRGKYIGGGVCI--------NCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCD 417
                    GGG C+         C  N  G+ C+ C DG++    + P   R CQ C CD
Sbjct: 1037 --------GGGACLCDPVTGACPCLPNVTGLACDRCADGYWN---LVPG--RGCQSCDCD 1083

Query: 418  PIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD--CKACNCSGLG 475
            P  S +  C +           G C CK G+GG  C  C   Y G P   C  C+C+  G
Sbjct: 1084 PRTSQSSHCDQ---------LTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPCDCNRAG 1134

Query: 476  SKNE--DPCFGPCICKENVEGGDCSRCKSG 503
            ++    DP  G C C+E V G  C RC  G
Sbjct: 1135 TQKPICDPDTGMCRCREGVSGQRCDRCARG 1164



 Score = 97.8 bits (242), Expect = 1e-19
 Identities = 71/239 (29%), Positives = 98/239 (41%), Gaps = 34/239 (14%)

Query: 722  EVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCF------------GHAESCDDV 769
            E  +C     G++C+ C P H    G+     C  C C             G A  CD V
Sbjct: 990  ECLRCLHNTQGANCQLCKPGH---YGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPV 1046

Query: 770  TGECLNCKDHTGGPYCDKCLPGFYG-EPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSL 828
            TG C  C  +  G  CD+C  G++   P +G    CQ C C         S + H D+  
Sbjct: 1047 TGAC-PCLPNVTGLACDRCADGYWNLVPGRG----CQSCDC-----DPRTSQSSHCDQLT 1096

Query: 829  GLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLI 888
            G     C +GY G RC  C E Y+G P    G C PC CN       P  CD  +G C  
Sbjct: 1097 GQC--PCKLGYGGKRCSECQENYYGDPP---GRCIPCDCN-RAGTQKP-ICDPDTGMCR- 1148

Query: 889  CKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQR 947
            C+ G +G+ C+ CA G+  +      C  C      + S +  +  G     AN++ +R
Sbjct: 1149 CREGVSGQRCDRCARGHSQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANMEDKR 1207



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 67/226 (29%), Positives = 88/226 (38%), Gaps = 50/226 (22%)

Query: 983  GQCWCQPGVTGKKCDRCAHGY--------FNFQEGGCTACECSHLGNNC--DPKT----- 1027
            GQC CQ    G  C+RC   +         + Q+  C +C C+   + C  D  T     
Sbjct: 293  GQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASG 352

Query: 1028 ----GRCI-CPPNTIGEKCSKCAPNTWGHSITT-----GCKACNCSTVGSLDFQCNVN-- 1075
                G C  C  NT G+ C +C P  +   + T      C  C C   G++     V+  
Sbjct: 353  GLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHS 412

Query: 1076 -------TGQCNCHPKFSGAKCTECSRGHWNYPR-----CNLCDCFLPGT-DATTCDSET 1122
                    GQC C     GAKC +C   H+         C  CDC   G+    TCD +T
Sbjct: 413  DPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDT 472

Query: 1123 KKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC 1168
                     GQC C   V G HC+ C  G +GL   +  GCS C C
Sbjct: 473  ---------GQCLCLSYVTGAHCEECTVGYWGL-GNHLHGCSPCDC 508



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 73/249 (29%), Positives = 94/249 (37%), Gaps = 44/249 (17%)

Query: 287  CICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNC 346
            C C   A  C  DP T  S   C   T G +C++C  G++  P       +   C  C C
Sbjct: 863  CPCNRFAELC--DPETG-SCFNCGGFTTGRNCERCIDGYYGNP------SSGQPCRPCLC 913

Query: 347  HGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPN 406
                    Y  +   +NL            V  NC Q   G  C  C+ GF+    +S  
Sbjct: 914  PDDPSSNQYFAHSCYQNLW--------SSDVICNCLQGYTGTQCGECSTGFYGNPRISG- 964

Query: 407  YPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC-HCKTGFGGVSCDRCARGYTGYP- 464
               PCQPC C+     N + V D +   R    G C  C     G +C  C  G+ G   
Sbjct: 965  --APCQPCACN-----NNIDVTDPESCSR--VTGECLRCLHNTQGANCQLCKPGHYGSAL 1015

Query: 465  --DCKACNCSGLG-SKNE----------DPCFGPCICKENVEGGDCSRCKSGFFNLQEDN 511
               C+ C+C   G S  E          DP  G C C  NV G  C RC  G++NL    
Sbjct: 1016 NQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPG- 1074

Query: 512  WKGCDECFC 520
             +GC  C C
Sbjct: 1075 -RGCQSCDC 1082



 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 64/245 (26%), Positives = 93/245 (37%), Gaps = 45/245 (18%)

Query: 296  CPLDPATNKSR--------------CECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC 341
            CP DP++N+                C C     G  C +C  GF+  P  +G       C
Sbjct: 913  CPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGA-----PC 967

Query: 342  EACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPK 401
            + C C+   +     E+ +R              G C+ C  NT G NC+ C  G +   
Sbjct: 968  QPCACNNNIDVTD-PESCSRVT------------GECLRCLHNTQGANCQLCKPGHY--- 1011

Query: 402  GVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYT 461
            G + N  + C+ C C   G     C             G+C C     G++CDRCA GY 
Sbjct: 1012 GSALN--QTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYW 1069

Query: 462  GYPD---CKACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCD 516
                   C++C+C    S++   D   G C CK    G  CS C+  ++    D    C 
Sbjct: 1070 NLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYG---DPPGRCI 1126

Query: 517  ECFCS 521
             C C+
Sbjct: 1127 PCDCN 1131



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 58/179 (32%), Positives = 77/179 (43%), Gaps = 36/179 (20%)

Query: 1420 CQCNGHSSLCDPETSICQN-------------CQHHTAGDFCERCALGYYGIVKGLP--- 1463
            C CNGH+S C P   +  +             CQH+T G  CERC   ++      P   
Sbjct: 265  CFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCK-DFFQDAPWRPAAD 323

Query: 1464 ---NDCQQCACPLISSSNNFSPSC--VAEGLDDYRCTACPRGYEGQYCERCAPGYTGSP- 1517
               N C+ C+C   SS  +F  +    + GL    C  C    EGQ+C+RC P +   P 
Sbjct: 324  LQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPL 383

Query: 1518 ---GNPGGSCQECECDPYGSLP-----VPCDP----VTGFCTCRPGATGRKCDGCKHWH 1564
                +P  +C  CECDP G++         DP    V G C C+    G KCD CK  H
Sbjct: 384  KTISDPY-ACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNH 441



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 46/132 (34%), Positives = 57/132 (43%), Gaps = 23/132 (17%)

Query: 1056 GCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWN--YPRCNLCDCFLPGT 1113
            G  AC C   GS+   C+   GQC C P   G  C  CS G ++  +  C+ C C   G+
Sbjct: 765  GAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGS 824

Query: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCS--------- 1164
              T CD           TGQC C   V G  CDRC  G FG  + +P  C+         
Sbjct: 825  KDTVCD---------QVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPCNRFAELCDPE 875

Query: 1165 --SCY-CFGTTT 1173
              SC+ C G TT
Sbjct: 876  TGSCFNCGGFTT 887



 Score = 75.9 bits (185), Expect = 6e-13
 Identities = 46/147 (31%), Positives = 60/147 (40%), Gaps = 19/147 (12%)

Query: 375 GGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHAR 434
           GG C  C     G  C+ C+ G +            C PCHC P GS + VC +      
Sbjct: 785 GGQC-QCKPLVVGRCCDRCSTGSYDLGH------HGCHPCHCHPQGSKDTVCDQ------ 831

Query: 435 RGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCI-CKENVE 493
                G C C     G  CDRC  GY G+P C  C C+   ++  DP  G C  C     
Sbjct: 832 ---VTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPCNRF-AELCDPETGSCFNCGGFTT 887

Query: 494 GGDCSRCKSGFFNLQEDNWKGCDECFC 520
           G +C RC  G++     + + C  C C
Sbjct: 888 GRNCERCIDGYYG-NPSSGQPCRPCLC 913



 Score = 72.8 bits (177), Expect = 5e-12
 Identities = 48/188 (25%), Positives = 72/188 (38%), Gaps = 50/188 (26%)

Query: 284  GGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEA 343
            GG C+C         DP T    C C  N  G +CD+C  G+    W     +    C++
Sbjct: 1038 GGACLC---------DPVTGA--CPCLPNVTGLACDRCADGY----WN---LVPGRGCQS 1079

Query: 344  CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGV 403
            C+C  +  +  + + +                G C  C     G  C  C + ++     
Sbjct: 1080 CDCDPRTSQSSHCDQLT---------------GQC-PCKLGYGGKRCSECQENYYGDP-- 1121

Query: 404  SPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYT-G 462
                P  C PC C+  G+   +C  D          G C C+ G  G  CDRCARG++  
Sbjct: 1122 ----PGRCIPCDCNRAGTQKPICDPDT---------GMCRCREGVSGQRCDRCARGHSQE 1168

Query: 463  YPDCKACN 470
            +P C  C+
Sbjct: 1169 FPTCLQCH 1176



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 57/231 (24%), Positives = 83/231 (35%), Gaps = 59/231 (25%)

Query: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
           +C+C+    G  CD+C  G +         L    C  C+CH +  +    + V      
Sbjct: 787 QCQCKPLVVGRCCDRCSTGSYD--------LGHHGCHPCHCHPQGSKDTVCDQVT----- 833

Query: 366 LNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEV 425
                     G C  C    +G  C+ C  G+F        +P  C PC C+      E+
Sbjct: 834 ----------GQC-PCHGEVSGRRCDRCLAGYF-------GFPS-CHPCPCNRFA---EL 871

Query: 426 CVKDEKHARRGLAPGSCHCKTGFG-GVSCDRCARGYTGYPD----CKACNCSGLGSKNE- 479
           C  +          GSC    GF  G +C+RC  GY G P     C+ C C    S N+ 
Sbjct: 872 CDPET---------GSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQY 922

Query: 480 --DPCFGP-------CICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCS 521
               C+         C C +   G  C  C +GF+     +   C  C C+
Sbjct: 923 FAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACN 973



 Score = 65.5 bits (158), Expect = 8e-10
 Identities = 46/150 (30%), Positives = 63/150 (42%), Gaps = 18/150 (12%)

Query: 710 SYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAE----S 765
           S P  GS+A     C C     G+ C+ C P H  ++ T   G C+PC C         +
Sbjct: 412 SDPALGSVAGQ---CLCKENVEGAKCDQCKPNHYGLSATDPLG-CQPCDCNPLGSLPFLT 467

Query: 766 CDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLD 825
           CD  TG+CL C  +  G +C++C  G++G         C PC C +      +S  C   
Sbjct: 468 CDVDTGQCL-CLSYVTGAHCEECTVGYWG--LGNHLHGCSPCDCDI---GGAYSNVCSPK 521

Query: 826 RSLGLICDGCPVGYTGPRCERCAEGYFGQP 855
                 C+ C    TG  C   A GYF  P
Sbjct: 522 NGQ---CE-CRPHVTGRSCSEPAPGYFFAP 547



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 44/147 (29%), Positives = 59/147 (40%), Gaps = 23/147 (15%)

Query: 1418 VPCQCNGHSSL---CDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLI 1474
            V C+C+   S+   C      CQ C+    G  C+RC+ G Y +     + C  C C   
Sbjct: 767  VACKCHPQGSVGSSCSRLGGQCQ-CKPLVVGRCCDRCSTGSYDLGH---HGCHPCHCHPQ 822

Query: 1475 SSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGS 1534
             S +        +         C     G+ C+RC  GY G P     SC  C C+ +  
Sbjct: 823  GSKDTVCDQVTGQ-------CPCHGEVSGRRCDRCLAGYFGFP-----SCHPCPCNRFAE 870

Query: 1535 LPVPCDPVTGFC-TCRPGATGRKCDGC 1560
            L   CDP TG C  C    TGR C+ C
Sbjct: 871  L---CDPETGSCFNCGGFTTGRNCERC 894



 Score = 62.0 bits (149), Expect = 9e-09
 Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 15/83 (18%)

Query: 1376 LIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN---GHSSLCDPE 1432
            L  +C C LGY G  C  C   +Y           G   G C+PC CN       +CDP+
Sbjct: 1095 LTGQCPCKLGYGGKRCSECQENYY-----------GDPPGRCIPCDCNRAGTQKPICDPD 1143

Query: 1433 TSICQNCQHHTAGDFCERCALGY 1455
            T +C+ C+   +G  C+RCA G+
Sbjct: 1144 TGMCR-CREGVSGQRCDRCARGH 1165



 Score = 58.9 bits (141), Expect = 8e-08
 Identities = 50/179 (27%), Positives = 68/179 (37%), Gaps = 32/179 (17%)

Query: 1345 YGNFMRQS------RISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGF 1398
            YG+ + Q+        S +S      G G  +  P  +   C C    +GL+C+ C  G+
Sbjct: 1011 YGSALNQTCRRCSCHASGVSPMECPPGGGACLCDP--VTGACPCLPNVTGLACDRCADGY 1068

Query: 1399 YRLRSQPGGRTPGPTLGTCVPCQCN---GHSSLCDPETSICQNCQHHTAGDFCERCALGY 1455
            + L        PG     C  C C+     SS CD  T  C  C+    G  C  C   Y
Sbjct: 1069 WNL-------VPG---RGCQSCDCDPRTSQSSHCDQLTGQCP-CKLGYGGKRCSECQENY 1117

Query: 1456 YGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYT 1514
            YG     P  C  C C   + +    P C      D     C  G  GQ C+RCA G++
Sbjct: 1118 YG---DPPGRCIPCDC---NRAGTQKPICD----PDTGMCRCREGVSGQRCDRCARGHS 1166



 Score = 45.4 bits (106), Expect = 9e-04
 Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 13/81 (16%)

Query: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN---GHSSLCDPETSI 1435
            +C C    +G  CE C  G++ L         G  L  C PC C+    +S++C P+   
Sbjct: 474  QCLCLSYVTGAHCEECTVGYWGL---------GNHLHGCSPCDCDIGGAYSNVCSPKNGQ 524

Query: 1436 CQNCQHHTAGDFCERCALGYY 1456
            C+ C+ H  G  C   A GY+
Sbjct: 525  CE-CRPHVTGRSCSEPAPGYF 544



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 11/72 (15%)

Query: 484 GPCICKENVEGGDCSRCKSGFFNLQEDNWK--------GCDECFCSGVSNRCQSSYWTYG 535
           G C+C+ N +G +C RCK  F   Q+  W+         C  C C+  S+RC     TY 
Sbjct: 293 GQCVCQHNTDGPNCERCKDFF---QDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYL 349

Query: 536 KIQDMSGWYLTD 547
               +SG    D
Sbjct: 350 ASGGLSGGVCED 361



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 15/97 (15%)

Query: 1472 PLISSSNNFSPSCVAEGLDDYRCTAC--------PRGYEGQYCERCAPGYTGSPGNPGGS 1523
            P I+S  NF   C  + LD+Y+   C        P+   G  CER     +    +    
Sbjct: 713  PQINSLENF---CSKQDLDEYQLHNCVEIASAMGPQVLPGA-CERLIISMSAKLHD---G 765

Query: 1524 CQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
               C+C P GS+   C  + G C C+P   GR CD C
Sbjct: 766  AVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRC 802


>gi|148613884 netrin 1 [Homo sapiens]
          Length = 604

 Score =  246 bits (627), Expect = 3e-64
 Identities = 158/470 (33%), Positives = 235/470 (50%), Gaps = 54/470 (11%)

Query: 4   AAGVLLLLLLSGGLG----GVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCG 59
           AA   L+  + GG G      QA +P        H +R + P  +N A    +  ++TCG
Sbjct: 13  AAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCI-PDFVNAAFGKDVRVSSTCG 71

Query: 60  EKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKN----TWWQSPSI 115
            + P  YC + E   G+  R   C +CN  +S+P + HP     D  N    T WQS   
Sbjct: 72  -RPPARYCVVSER--GEE-RLRSCHLCN--ASDPKKAHPPAFLTDLNNPHNLTCWQS--- 122

Query: 116 KNGIEY-HYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLD-DVEYKPWQYHAVTD 173
           +N +++ H VT+TL L + F++ YV ++   SPRP +  + +S+D    + P+Q+++   
Sbjct: 123 ENYLQFPHNVTLTLSLGKKFEVTYVSLQFC-SPRPESMAIYKSMDYGRTWVPFQFYS--- 178

Query: 174 TECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADD--PSPE 231
           T+C  +YN  P   P +   + E +CT  ++ + PL  G I  S ++GRPSA D   SP 
Sbjct: 179 TQCRKMYN-RPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPV 237

Query: 232 LLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTR-RYYYSVKDISVGGMCICY 290
           L ++ +A  IR+ F R+ T           D  E D  + R  Y+Y+V D+ VGG C C 
Sbjct: 238 LQDWVTATDIRVAFSRLHTFG---------DENEDDSELARDSYFYAVSDLQVGGRCKCN 288

Query: 291 GHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKA 350
           GHA  C  D   +   C+C HNT G  CD+C P  + +PW+  T     EC ACNC+  A
Sbjct: 289 GHAARCVRD-RDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHA 347

Query: 351 EECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRP 410
             C       R N+ L        GGVC+NC  NTAG +C  C +G++R  G    + + 
Sbjct: 348 RRC-------RFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKA 400

Query: 411 CQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGY 460
           C+ C C P+G+  + C             G C CK G  G++C+RCA+GY
Sbjct: 401 CKACDCHPVGAAGKTC---------NQTTGQCPCKDGVTGITCNRCAKGY 441



 Score = 89.7 bits (221), Expect = 4e-17
 Identities = 52/169 (30%), Positives = 75/169 (44%), Gaps = 22/169 (13%)

Query: 816 NNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQP-----SVPGGSCQPCQCN-- 868
           N  +  C  DR   L+CD C     GP C+RC   ++ +P     +     C  C CN  
Sbjct: 288 NGHAARCVRDRDDSLVCD-CRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLH 346

Query: 869 -----DNLD-FSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDA----VDAKNCQPC 918
                 N++ + + G      G CL C+  T GR+C  C +GY+ D        K C+ C
Sbjct: 347 ARRCRFNMELYKLSGR--KSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKAC 404

Query: 919 RCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPC 967
            C+  G+  + C+  TGQC C+  V G  C++C  G    QS     PC
Sbjct: 405 DCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGY--QQSRSPIAPC 451



 Score = 87.8 bits (216), Expect = 2e-16
 Identities = 47/153 (30%), Positives = 71/153 (46%), Gaps = 12/153 (7%)

Query: 1420 CQCNGHSSLC--DPETSICQNCQHHTAGDFCERCALGYYG-----IVKGLPNDCQQCACP 1472
            C+CNGH++ C  D + S+  +C+H+TAG  C+RC   +Y            N+C  C C 
Sbjct: 285  CKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCN 344

Query: 1473 LISSSNNFSPSC--VAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNP---GGSCQEC 1527
            L +    F+     ++       C  C     G++C  C  GY    G P     +C+ C
Sbjct: 345  LHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKAC 404

Query: 1528 ECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC 1560
            +C P G+    C+  TG C C+ G TG  C+ C
Sbjct: 405  DCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRC 437



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 51/160 (31%), Positives = 71/160 (44%), Gaps = 14/160 (8%)

Query: 757 CQCFGHAESC--DDVTGECLNCKDHTGGPYCDKCLPGFYGEP----TKGTSEDCQPCACP 810
           C+C GHA  C  D       +C+ +T GP CD+C P  Y  P    T   + +C  C C 
Sbjct: 285 CKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCN 344

Query: 811 LNIPSNNFSPTCH--LDRSLGLICDGCPVGYTGPRCERCAEGYF---GQPSVPGGSCQPC 865
           L+     F+   +    R  G +C  C     G  C  C EGY+   G+P     +C+ C
Sbjct: 345 LHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKAC 404

Query: 866 QCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGY 905
            C+     +   +C+  +G C  CK G TG  C  CA GY
Sbjct: 405 DCHP--VGAAGKTCNQTTGQC-PCKDGVTGITCNRCAKGY 441



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 55/205 (26%), Positives = 82/205 (40%), Gaps = 31/205 (15%)

Query: 967  CNCNSFGSKSF-DCEESGQCWCQPGVTGKKCDRCAHGYFNF--------QEGGCTACECS 1017
            C CN   ++   D ++S  C C+    G +CDRC   +++         +   C AC C+
Sbjct: 285  CKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCN 344

Query: 1018 HLGNNCD-----------PKTGRCI-CPPNTIGEKCSKCAPNTW---GHSIT--TGCKAC 1060
                 C               G C+ C  NT G  C  C    +   G  IT    CKAC
Sbjct: 345  LHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKAC 404

Query: 1061 NCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCF----LPGTDAT 1116
            +C  VG+    CN  TGQC C    +G  C  C++G +   R  +  C      P T A 
Sbjct: 405  DCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKG-YQQSRSPIAPCIKIPVAPPTTAA 463

Query: 1117 TCDSETKKCSCSDQTGQCTCKVNVE 1141
            +   E + C    +  +   K+N++
Sbjct: 464  SSVEEPEDCDSYCKASKGKLKINMK 488



 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 49/173 (28%), Positives = 68/173 (39%), Gaps = 26/173 (15%)

Query: 899  ELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFG- 957
            EL  D YF    D +    C+CN   +        +  C+CR N  G  CD+CK   +  
Sbjct: 266  ELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDR 325

Query: 958  ------LQSARGCVPCNCNSFGSK-SFDCE--------ESGQCW-CQPGVTGKKCDRCAH 1001
                   + A  CV CNCN    +  F+ E          G C  C+    G+ C  C  
Sbjct: 326  PWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKE 385

Query: 1002 GYFN------FQEGGCTACECSHL---GNNCDPKTGRCICPPNTIGEKCSKCA 1045
            GY+            C AC+C  +   G  C+  TG+C C     G  C++CA
Sbjct: 386  GYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCA 438



 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 44/152 (28%), Positives = 57/152 (37%), Gaps = 26/152 (17%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCD--------- 1430
            CDC    +G  C+ C P  Y    +P  R        CV C CN H+  C          
Sbjct: 304  CDCRHNTAGPECDRCKPFHY---DRPWQRATAREANECVACNCNLHARRCRFNMELYKLS 360

Query: 1431 --PETSICQNCQHHTAGDFCERCALGYYGIVKGLP----NDCQQCACPLISSSNNFSPSC 1484
                  +C NC+H+TAG  C  C  GYY  + G P      C+ C C  + ++       
Sbjct: 361  GRKSGGVCLNCRHNTAGRHCHYCKEGYYRDM-GKPITHRKACKACDCHPVGAAGKTCNQT 419

Query: 1485 VAEGLDDYRCTACPRGYEGQYCERCAPGYTGS 1516
              +         C  G  G  C RCA GY  S
Sbjct: 420  TGQ-------CPCKDGVTGITCNRCAKGYQQS 444



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 44/149 (29%), Positives = 55/149 (36%), Gaps = 39/149 (26%)

Query: 1030 CICPPNTIGEKCSKCAP----NTWGHSIT---TGCKACNCSTVGSLDFQCNVNT------ 1076
            C C  NT G +C +C P      W  +       C ACNC+       +C  N       
Sbjct: 304  CDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHAR---RCRFNMELYKLS 360

Query: 1077 -----GQC-NCHPKFSGAKCTECSRGHW--------NYPRCNLCDCFLPGTDATTCDSET 1122
                 G C NC    +G  C  C  G++        +   C  CDC   G    TC+  T
Sbjct: 361  GRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTT 420

Query: 1123 KKCSCSDQTGQCTCKVNVEGIHCDRCRPG 1151
                     GQC CK  V GI C+RC  G
Sbjct: 421  ---------GQCPCKDGVTGITCNRCAKG 440



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 49/173 (28%), Positives = 70/173 (40%), Gaps = 28/173 (16%)

Query: 344 CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFF-RP-K 401
           C C+G A  C  D     R+ SL          VC +C  NTAG  C+ C    + RP +
Sbjct: 285 CKCNGHAARCVRD-----RDDSL----------VC-DCRHNTAGPECDRCKPFHYDRPWQ 328

Query: 402 GVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGY- 460
             +      C  C+C+         ++  K + R       +C+    G  C  C  GY 
Sbjct: 329 RATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYY 388

Query: 461 -------TGYPDCKACNCSGLGS--KNEDPCFGPCICKENVEGGDCSRCKSGF 504
                  T    CKAC+C  +G+  K  +   G C CK+ V G  C+RC  G+
Sbjct: 389 RDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGY 441



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 45/152 (29%), Positives = 58/152 (38%), Gaps = 36/152 (23%)

Query: 723 VCQCPPGYTGSSCESCWPRH----------RRVNGTIFGGICEPCQCFGHAESCD----- 767
           VC C     G  C+ C P H          R  N       C  C C  HA  C      
Sbjct: 303 VCDCRHNTAGPECDRCKPFHYDRPWQRATAREANE------CVACNCNLHARRCRFNMEL 356

Query: 768 ------DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFS 819
                    G CLNC+ +T G +C  C  G+Y +  K  +  + C+ C C    P     
Sbjct: 357 YKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCH---PVGAAG 413

Query: 820 PTCHLDRSLGLICDGCPVGYTGPRCERCAEGY 851
            TC  +++ G     C  G TG  C RCA+GY
Sbjct: 414 KTC--NQTTGQC--PCKDGVTGITCNRCAKGY 441



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 42/172 (24%), Positives = 62/172 (36%), Gaps = 39/172 (22%)

Query: 1079 CNCHPKFSGAKCTECSRGHWNYP----------RCNLCDCFLPGTDATTC--DSETKKCS 1126
            C+C    +G +C  C   H++ P           C  C+C L    A  C  + E  K S
Sbjct: 304  CDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNL---HARRCRFNMELYKLS 360

Query: 1127 CSDQTGQC-TCKVNVEGIHCDRCRPGKFGLDAK-------------NPLGCSSCYCFGTT 1172
                 G C  C+ N  G HC  C+ G +    K             +P+G +   C  TT
Sbjct: 361  GRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTT 420

Query: 1173 TQCSEAKGLIRTWVTL--------KAEQTILPLVDEALQHTTTKGIVFQHPE 1216
             QC    G+  T +T         ++   I P +   +   TT     + PE
Sbjct: 421  GQCPCKDGV--TGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPE 470



 Score = 39.7 bits (91), Expect = 0.047
 Identities = 30/119 (25%), Positives = 43/119 (36%), Gaps = 24/119 (20%)

Query: 442 CHCKTGFGGVSCDRCARGYTGYP----------DCKACNCS----------GLGSKNEDP 481
           C C+    G  CDRC   +   P          +C ACNC+           L   +   
Sbjct: 304 CDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRK 363

Query: 482 CFGPCI-CKENVEGGDCSRCKSGFF---NLQEDNWKGCDECFCSGVSNRCQSSYWTYGK 536
             G C+ C+ N  G  C  CK G++        + K C  C C  V    ++   T G+
Sbjct: 364 SGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQ 422



 Score = 35.0 bits (79), Expect = 1.2
 Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 9/57 (15%)

Query: 1527 CECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWH---------AREGWECVFC 1574
            C+C+ + +  V     +  C CR    G +CD CK +H         ARE  ECV C
Sbjct: 285  CKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVAC 341



 Score = 33.1 bits (74), Expect = 4.4
 Identities = 27/114 (23%), Positives = 37/114 (32%), Gaps = 21/114 (18%)

Query: 1468 QCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSP-----GNPGG 1522
            +C C      N  +  CV +  D   C  C     G  C+RC P +   P          
Sbjct: 284  RCKC------NGHAARCVRDRDDSLVCD-CRHNTAGPECDRCKPFHYDRPWQRATAREAN 336

Query: 1523 SCQECECDPYGS--------LPVPCDPVTGFC-TCRPGATGRKCDGCKHWHARE 1567
             C  C C+ +            +      G C  CR    GR C  CK  + R+
Sbjct: 337  ECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRD 390


>gi|93204871 netrin 4 [Homo sapiens]
          Length = 628

 Score =  209 bits (532), Expect = 3e-53
 Identities = 165/525 (31%), Positives = 231/525 (44%), Gaps = 103/525 (19%)

Query: 3   GAAGVLLLL----LLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATC 58
           G+   LLLL    +++ GL GV     + ++           P + NLA    +  + TC
Sbjct: 2   GSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACN--------PRMGNLALGRKLWADTTC 53

Query: 59  GEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGK----NTWWQSPS 114
           G+   E+YC   E+      R P+C  CN  ++ P+  H  +   D       TWWQS  
Sbjct: 54  GQNATELYCFYSENTD-LTCRQPKCDKCN--AAYPHLAHLPSAMADSSFRFPRTWWQSAE 110

Query: 115 IKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLD-DVEYKPWQYHAVTD 173
                + H   I LDL+  F   ++IV    SPRP   +L+RS D    +KP++Y A   
Sbjct: 111 -----DVHREKIQLDLEAEFYFTHLIVMF-KSPRPAAMVLDRSQDFGKTWKPYKYFA--- 161

Query: 174 TECLTLYNIYPRTGPPSYAKDDEV----ICTSFYSKIHPLENGEIHISLINGRPSADDPS 229
           T C   + +          +DD V    ICTS YS   P   GE+    ++  P  D  +
Sbjct: 162 TNCSATFGL----------EDDVVKKGAICTSKYSSPFPCTGGEVIFKALS--PPYDTEN 209

Query: 230 P------ELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISV 283
           P      E L+ T+ R   L+ Q       DL    +++P+          +Y++ D  V
Sbjct: 210 PYSAKVQEQLKITNLRVQLLKRQSCPCQRNDL----NEEPQHFT-------HYAIYDFIV 258

Query: 284 GGMCICYGHARAC-------PLD-PATNK---SRCECEHNTCGDSCDQCCPGFHQKPWRA 332
            G C C GHA  C       P+  P T      +C C+HNT G  C  C P ++ +PW A
Sbjct: 259 KGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEA 318

Query: 333 GTFLT--KTECEACNCHGKAEECYYDENV--ARRNLSLNIRGKYIGGGVCINCTQNTAGI 388
               T    EC  C C+G A+ C++D NV  A  N S         GGVC +C  NT G 
Sbjct: 319 ADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRS---------GGVCDDCQHNTEGQ 369

Query: 389 NCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGS----LNEVCVKDEKHARRGLAPGSCHC 444
            C+ C  GF+R      + P  C+PC C P+GS     N V   D  +       G C C
Sbjct: 370 YCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSN-------GDCPC 422

Query: 445 KTGFGGVSCDRCARGYTGYPD--CKACNCSGLGSKNEDPCFGPCI 487
           K G  G  CDRC  GY G+ D  C+ C+C+G    + DP  G CI
Sbjct: 423 KPGVAGRRCDRCMVGYWGFGDYGCRPCDCAG----SCDPITGDCI 463



 Score =  113 bits (283), Expect = 3e-24
 Identities = 78/270 (28%), Positives = 114/270 (42%), Gaps = 64/270 (23%)

Query: 865  CQCNDNLDFSIP----------GSCDSLSGSCLICKPGTTGRYCELCADGYFG---DAVD 911
            C CN + D  IP          G+   + G C+ CK  T G +C+ CA  Y     +A D
Sbjct: 262  CFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCM-CKHNTAGSHCQHCAPLYNDRPWEAAD 320

Query: 912  AKN-----CQPCRCNAGGSFSEVCHSQT-----------GQCE-CRANVQGQRCDKCKAG 954
             K      C+ C+CN     ++ CH              G C+ C+ N +GQ C +CK G
Sbjct: 321  GKTGAPNECRTCKCNG---HADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPG 377

Query: 955  TFG-----LQSARGCVPCNCNSFGSK-------SFDCEESGQCWCQPGVTGKKCDRCAHG 1002
             +        +   C PC+C+  GS        +F    +G C C+PGV G++CDRC  G
Sbjct: 378  FYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVG 437

Query: 1003 YFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNC 1062
            Y+ F + GC  C+C+    +CDP TG CI     I           W H +       N 
Sbjct: 438  YWGFGDYGCRPCDCA---GSCDPITGDCISSHTDI----------DWYHEVPDFRPVHNK 484

Query: 1063 STVG-----SLDFQCNVNTGQCNCHPKFSG 1087
            S        +  F   +++G+C C  +  G
Sbjct: 485  SEPAWEWEDAQGFSALLHSGKCECKEQTLG 514



 Score =  100 bits (248), Expect = 3e-20
 Identities = 66/217 (30%), Positives = 92/217 (42%), Gaps = 52/217 (23%)

Query: 757 CQCFGHAESC---------------DDVTGECLNCKDHTGGPYCDKCLPGFYGEPTK--- 798
           C C GHA+ C                 V G+C+ CK +T G +C  C P +   P +   
Sbjct: 262 CFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCM-CKHNTAGSHCQHCAPLYNDRPWEAAD 320

Query: 799 ---GTSEDCQPCACPLNIPSNNFSPTCHLDRSL--------GLICDGCPVGYTGPRCERC 847
              G   +C+ C C      N  + TCH D ++        G +CD C     G  C+RC
Sbjct: 321 GKTGAPNECRTCKC------NGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRC 374

Query: 848 AEGYF---GQPSVPGGSCQPCQCNDNLDFSIPGS----CDSLSGSCLICKPGTTGRYCEL 900
             G++    +P     +C+PC C+      +P +    CD  +G C  CKPG  GR C+ 
Sbjct: 375 KPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDC-PCKPGVAGRRCDR 433

Query: 901 CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQC 937
           C  GY+G       C+PC C AG      C   TG C
Sbjct: 434 CMVGYWG--FGDYGCRPCDC-AGS-----CDPITGDC 462



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 56/174 (32%), Positives = 75/174 (43%), Gaps = 34/174 (19%)

Query: 1420 CQCNGHSSLCDPETSI---------------CQNCQHHTAGDFCERCALGYYGIV----- 1459
            C CNGH+  C P                   C  C+H+TAG  C+ CA  Y         
Sbjct: 262  CFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCM-CKHNTAGSHCQHCAPLYNDRPWEAAD 320

Query: 1460 --KGLPNDCQQCACPLISSSNNFSPSC--VAEGLDDYRCTACPRGYEGQYCERCAPGYTG 1515
               G PN+C+ C C   + + +F  +    +       C  C    EGQYC+RC PG+  
Sbjct: 321  GKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYR 380

Query: 1516 S---PGNPGGSCQECECDPYGSLPVP------CDPVTGFCTCRPGATGRKCDGC 1560
                P +   +C+ C C P GS  +P      CDP  G C C+PG  GR+CD C
Sbjct: 381  DLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRC 434



 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 58/183 (31%), Positives = 87/183 (47%), Gaps = 27/183 (14%)

Query: 1379 KCDCPLGYSGLSCEACLPGFY-RLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETS--- 1434
            KC C    +G  C+ C P +  R      G+T  P    C  C+CNGH+  C  + +   
Sbjct: 292  KCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPN--ECRTCKCNGHADTCHFDVNVWE 349

Query: 1435 --------ICQNCQHHTAGDFCERCALGYYGIVK---GLPNDCQQCACPLISSSNNFSPS 1483
                    +C +CQH+T G +C+RC  G+Y  ++     P+ C+ C+C  + S+   + S
Sbjct: 350  ASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANS 409

Query: 1484 CVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVT 1543
                   +  C  C  G  G+ C+RC  GY G  G+ G  C+ C+C   GS    CDP+T
Sbjct: 410  VTFCDPSNGDC-PCKPGVAGRRCDRCMVGYWGF-GDYG--CRPCDC--AGS----CDPIT 459

Query: 1544 GFC 1546
            G C
Sbjct: 460  GDC 462



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 61/187 (32%), Positives = 86/187 (45%), Gaps = 39/187 (20%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGGI------CEPCQCFGHAESCD-DVT------ 770
           C C     GS C+ C P +         G       C  C+C GHA++C  DV       
Sbjct: 293 CMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASG 352

Query: 771 ----GECLNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCAC-PLN---IPSNNFSP 820
               G C +C+ +T G YC +C PGFY +  +  S  + C+PC+C P+    +P+N+ + 
Sbjct: 353 NRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVT- 411

Query: 821 TCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCD 880
               D S G  C  C  G  G RC+RC  GY+G        C+PC C         GSCD
Sbjct: 412 --FCDPSNG-DCP-CKPGVAGRRCDRCMVGYWGFGDY---GCRPCDC--------AGSCD 456

Query: 881 SLSGSCL 887
            ++G C+
Sbjct: 457 PITGDCI 463



 Score = 72.8 bits (177), Expect = 5e-12
 Identities = 50/181 (27%), Positives = 69/181 (38%), Gaps = 41/181 (22%)

Query: 983  GQCWCQPGVTGKKCDRCAHGY----FNFQEGG------CTACECSHLGNNC--------- 1023
            G+C C+    G  C  CA  Y    +   +G       C  C+C+   + C         
Sbjct: 291  GKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEA 350

Query: 1024 --DPKTGRCI-CPPNTIGEKCSKCAPNTWGH-----SITTGCKACNCSTVGSLDFQ---- 1071
              +   G C  C  NT G+ C +C P  +       S    CK C+C  VGS        
Sbjct: 351  SGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSV 410

Query: 1072 --CNVNTGQCNCHPKFSGAKCTECSRGHWNYP--RCNLCDCFLPGTDATTCDSETKKCSC 1127
              C+ + G C C P  +G +C  C  G+W +    C  CDC      A +CD  T  C  
Sbjct: 411  TFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDC------AGSCDPITGDCIS 464

Query: 1128 S 1128
            S
Sbjct: 465  S 465



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 51/170 (30%), Positives = 64/170 (37%), Gaps = 32/170 (18%)

Query: 1028 GRCICPPNTIGEKCSKCAP----NTWGHSI-TTG----CKACNCST-VGSLDFQCNV--- 1074
            G+C+C  NT G  C  CAP      W  +   TG    C+ C C+    +  F  NV   
Sbjct: 291  GKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEA 350

Query: 1075 ----NTGQCN-CHPKFSGAKCTECSRGHWNYPR--------CNLCDCFLPGTDATTCDSE 1121
                + G C+ C     G  C  C  G +   R        C  C C   G+     +S 
Sbjct: 351  SGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSV 410

Query: 1122 TKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGT 1171
            T    C    G C CK  V G  CDRC  G +G       GC  C C G+
Sbjct: 411  T---FCDPSNGDCPCKPGVAGRRCDRCMVGYWGF---GDYGCRPCDCAGS 454



 Score = 55.5 bits (132), Expect = 8e-07
 Identities = 36/119 (30%), Positives = 47/119 (39%), Gaps = 20/119 (16%)

Query: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSS---------LCDP 1431
            DC     G  C+ C PGFYR       R P      C PC C+   S          CDP
Sbjct: 361  DCQHNTEGQYCQRCKPGFYR-----DLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDP 415

Query: 1432 ETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLD 1490
                C  C+   AG  C+RC +GY+G        C+ C C    S +  +  C++   D
Sbjct: 416  SNGDCP-CKPGVAGRRCDRCMVGYWGFG---DYGCRPCDC--AGSCDPITGDCISSHTD 468



 Score = 42.0 bits (97), Expect = 0.010
 Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 9/53 (16%)

Query: 724 CQCPPGYTGSSCESCWPRHRRVNGTIFGGI-CEPCQCFGHAESCDDVTGECLN 775
           C C PG  G  C+ C      V    FG   C PC C G   SCD +TG+C++
Sbjct: 420 CPCKPGVAGRRCDRCM-----VGYWGFGDYGCRPCDCAG---SCDPITGDCIS 464


>gi|62868217 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  200 bits (509), Expect = 2e-50
 Identities = 145/521 (27%), Positives = 225/521 (43%), Gaps = 88/521 (16%)

Query: 32  QAHQQRGLFPAV--LNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQN 89
           QA  +   +P V  L +     +  ++TCG   PE YC              Q + C  +
Sbjct: 19  QACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEW--------QMKCCKCD 70

Query: 90  SSNPNQ--RHPITNAID--GKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAAN 145
           S  P+    H + N     G   WWQS +  N      V++ LDL + FQ+  V+++   
Sbjct: 71  SRQPHNYYSHRVENVASSSGPMRWWQSQNDVNP-----VSLQLDLDRRFQLQEVMMEF-Q 124

Query: 146 SPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSK 205
            P P   ++ERS D    K W+ +     +C + +    +  P S+    +V C S   +
Sbjct: 125 GPMPAGMLIERSSDFG--KTWRVYQYLAADCTSTFPRVRQGRPQSW---QDVRCQSLPQR 179

Query: 206 IHP-LENGEIHISL---INGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261
            +  L  G++ ++L   ++G P+    S ++ E      +R+ F R+             
Sbjct: 180 PNARLNGGKVQLNLMDLVSGIPATQ--SQKIQEVGEITNLRVNFTRLA------------ 225

Query: 262 DPREIDPIVTRRY-----YYSVKDISVGGMCICYGHARACPLDPATNKSR---------C 307
                 P+  R Y     YY+V  + + G C C+GHA  C   P  +            C
Sbjct: 226 ------PVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC 279

Query: 308 ECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLN 367
            C+HNT G +C++C P ++ +PWR        EC+ C+C+G +E C++D  V   +    
Sbjct: 280 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS---- 335

Query: 368 IRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCV 427
            +G Y  GGVC NC  +T G NCE C   +FR +    +    C  C CDP G++     
Sbjct: 336 -QGAY--GGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV----- 387

Query: 428 KDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGY-----PDCKACNCSGLGSKNEDPC 482
                A      G C CK    G  CD C  G+TG        C  C+C+ LGS+ + PC
Sbjct: 388 ---PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPC 444

Query: 483 ---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
               G C+C  NV G  C +C    + L   + +GC+ C C
Sbjct: 445 DEESGRCLCLPNVVGPKCDQCAPYHWKLA--SGQGCEPCAC 483



 Score =  182 bits (463), Expect = 3e-45
 Identities = 107/328 (32%), Positives = 153/328 (46%), Gaps = 50/328 (15%)

Query: 757  CQCFGHAESCDDVTG------------ECLNCKDHTGGPYCDKCLPGFYGEPTKGT---- 800
            C C GHA+ C    G            +   C+ +T GP C++C P +   P +      
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309

Query: 801  SEDCQPCACPLNIPSNNFSPTCHLDRSL--------GLICDGCPVGYTGPRCERCAEGYF 852
            + +CQ C C      N  S TCH D ++        G +CD C     G  CERC   YF
Sbjct: 310  AHECQRCDC------NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363

Query: 853  GQPSVPGGS----CQPCQCNDNLDFSIPGS-CDSLSGSCLICKPGTTGRYCELCADGYFG 907
             +   PG S    C  C+C+   D ++PG+ CD ++G C +CK    G  C+LC  G+ G
Sbjct: 364  -RNRRPGASIQETCISCECDP--DGAVPGAPCDPVTGQC-VCKEHVQGERCDLCKPGFTG 419

Query: 908  -DAVDAKNCQPCRCNAGGSFSEV-CHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCV 965
                + + C  C CN  GS  ++ C  ++G+C C  NV G +CD+C    + L S +GC 
Sbjct: 420  LTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCE 479

Query: 966  PCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCD-----RCAHGYFNFQEGGCTACECSHL 1019
            PC C+   S S  C + +GQC C+ G  G  C      +C    +     GC AC+C   
Sbjct: 480  PCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFR 539

Query: 1020 GN---NCDPKTGRCICPPNTIGEKCSKC 1044
            G     CD  +GRC+C P   G +C +C
Sbjct: 540  GTEGPGCDKASGRCLCRPGLTGPRCDQC 567



 Score =  171 bits (433), Expect = 1e-41
 Identities = 104/324 (32%), Positives = 148/324 (45%), Gaps = 56/324 (17%)

Query: 888  ICKPGTTGRYCELCADGYFG------DAVDAKNCQPCRCNAGGSFSEVCH---------- 931
            +C+  T G  CE CA  Y        +  DA  CQ C CN     SE CH          
Sbjct: 280  VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNG---HSETCHFDPAVFAASQ 336

Query: 932  -SQTGQCE-CRANVQGQRCDKCKAGTF-----GLQSARGCVPCNCNSFGS-KSFDCEE-S 982
             +  G C+ CR + +G+ C++C+   F     G      C+ C C+  G+     C+  +
Sbjct: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVT 396

Query: 983  GQCWCQPGVTGKKCDRCAHGYFNFQEG---GCTACECSHLGNN----CDPKTGRCICPPN 1035
            GQC C+  V G++CD C  G+         GC  C+C+ LG+     CD ++GRC+C PN
Sbjct: 397  GQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPN 456

Query: 1036 TIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCT---- 1091
             +G KC +CAP  W  +   GC+ C C    SL  QCN  TGQC C   F G  C+    
Sbjct: 457  VVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAI 516

Query: 1092 -ECSRGHWN--YPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRC 1148
             +C    +      C  CDC   GT+   CD           +G+C C+  + G  CD+C
Sbjct: 517  RQCPDRTYGDVATGCRACDCDFRGTEGPGCDK---------ASGRCLCRPGLTGPRCDQC 567

Query: 1149 RPGKFGLDAKNPLGCSSCY-CFGT 1171
            + G      + P+ C +C+ CF T
Sbjct: 568  QRGYCN---RYPV-CVACHPCFQT 587



 Score =  159 bits (403), Expect = 3e-38
 Identities = 104/321 (32%), Positives = 137/321 (42%), Gaps = 44/321 (13%)

Query: 722  EVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI----CEPCQCFGHAESCD---------- 767
            +VC C     G +CE C P +         G     C+ C C GH+E+C           
Sbjct: 277  DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336

Query: 768  -DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFSPTCHL 824
                G C NC+DHT G  C++C   ++     G S  E C  C C      +   P    
Sbjct: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAPC 392

Query: 825  DRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGS-----C 879
            D   G     C     G RC+ C  G+ G        C  C CN      I GS     C
Sbjct: 393  DPVTGQCV--CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCN------ILGSRRDMPC 444

Query: 880  DSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCEC 939
            D  SG CL C P   G  C+ CA  Y       + C+PC C+   S S  C+  TGQC C
Sbjct: 445  DEESGRCL-CLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPC 502

Query: 940  RANVQGQRCD-----KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTG 993
            R    G  C      +C   T+G   A GC  C+C+  G++   C++ SG+C C+PG+TG
Sbjct: 503  REGFGGLMCSAAAIRQCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTG 561

Query: 994  KKCDRCAHGYFNFQEGGCTAC 1014
             +CD+C  GY N +   C AC
Sbjct: 562  PRCDQCQRGYCN-RYPVCVAC 581



 Score =  113 bits (282), Expect = 3e-24
 Identities = 72/213 (33%), Positives = 92/213 (43%), Gaps = 28/213 (13%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC--DPET---- 1433
            C C    +G +CE C P FY  R  P     G     C  C CNGHS  C  DP      
Sbjct: 279  CVCQHNTAGPNCERCAP-FYNNR--PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS 335

Query: 1434 -----SICQNCQHHTAGDFCERCALGYYGIVK---GLPNDCQQCACPLISSSNNFSPSCV 1485
                  +C NC+ HT G  CERC L Y+   +    +   C  C C      +   P   
Sbjct: 336  QGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAP 391

Query: 1486 AEGLDDYRCTACPRGYEGQYCERCAPGYTG-SPGNPGGSCQECECDPYGS-LPVPCDPVT 1543
             + +   +C  C    +G+ C+ C PG+TG +  NP G C  C+C+  GS   +PCD  +
Sbjct: 392  CDPVTG-QC-VCKEHVQGERCDLCKPGFTGLTYANPQG-CHRCDCNILGSRRDMPCDEES 448

Query: 1544 GFCTCRPGATGRKCDGCK--HWHAREGWECVFC 1574
            G C C P   G KCD C   HW    G  C  C
Sbjct: 449  GRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPC 481



 Score =  102 bits (254), Expect = 6e-21
 Identities = 64/167 (38%), Positives = 83/167 (49%), Gaps = 27/167 (16%)

Query: 1420 CQCNGHSSLCDPET-------------SICQNCQHHTAGDFCERCALGY----YGIVKGL 1462
            C C+GH+  C P+               +C  CQH+TAG  CERCA  Y    +   +G 
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEGQ 308

Query: 1463 -PNDCQQCACPLISSSNNFSPSCVAEGLDDYR--CTACPRGYEGQYCERCAPGYTGSPGN 1519
              ++CQ+C C   S + +F P+  A     Y   C  C    EG+ CERC   Y  +   
Sbjct: 309  DAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN-RR 367

Query: 1520 PGGSCQE----CECDPYGSLP-VPCDPVTGFCTCRPGATGRKCDGCK 1561
            PG S QE    CECDP G++P  PCDPVTG C C+    G +CD CK
Sbjct: 368  PGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 65/246 (26%), Positives = 95/246 (38%), Gaps = 58/246 (23%)

Query: 1380 CD-CPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLG-TCVPCQCNGHSSL----CDPET 1433
            CD C     G +CE C   ++R       R PG ++  TC+ C+C+   ++    CDP T
Sbjct: 343  CDNCRDHTEGKNCERCQLHYFR------NRRPGASIQETCISCECDPDGAVPGAPCDPVT 396

Query: 1434 SICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSS---------------- 1477
              C  C+ H  G+ C+ C  G+ G+    P  C +C C ++ S                 
Sbjct: 397  GQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLP 455

Query: 1478 NNFSPSC---------VAEGLDDYRCTACPRGYEGQYCER------CAPGYTG------- 1515
            N   P C         +A G     C   P       C +      C  G+ G       
Sbjct: 456  NVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA 515

Query: 1516 -------SPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREG 1568
                   + G+    C+ C+CD  G+    CD  +G C CRPG TG +CD C+  +    
Sbjct: 516  IRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRY 575

Query: 1569 WECVFC 1574
              CV C
Sbjct: 576  PVCVAC 581



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 69/259 (26%), Positives = 102/259 (39%), Gaps = 50/259 (19%)

Query: 272 RRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWR 331
           RR   S+++  +   C   G     P DP T +  C C+ +  G+ CD C PGF      
Sbjct: 366 RRPGASIQETCISCECDPDGAVPGAPCDPVTGQ--CVCKEHVQGERCDLCKPGF-----T 418

Query: 332 AGTFLTKTECEACNCH--GKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGIN 389
             T+     C  C+C+  G   +   DE   R                C+ C  N  G  
Sbjct: 419 GLTYANPQGCHRCDCNILGSRRDMPCDEESGR----------------CL-CLPNVVGPK 461

Query: 390 CETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449
           C+ C    ++         + C+PC CDP  SL+  C +           G C C+ GFG
Sbjct: 462 CDQCAPYHWKLAS-----GQGCEPCACDPHNSLSPQCNQ---------FTGQCPCREGFG 507

Query: 450 GVSCDRCA------RGYTGYPD-CKACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRC 500
           G+ C   A      R Y      C+AC+C   G++    D   G C+C+  + G  C +C
Sbjct: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC 567

Query: 501 KSGFFNLQEDNWKGCDECF 519
           + G+ N +      C  CF
Sbjct: 568 QRGYCN-RYPVCVACHPCF 585



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 62/202 (30%), Positives = 88/202 (43%), Gaps = 29/202 (14%)

Query: 343 ACNCHGKAEECYYDENV-ARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPK 401
           +C CHG A+ C       A  + ++ +        VC+ C  NTAG NCE C   F+  +
Sbjct: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHD------VCV-CQHNTAGPNCERCAP-FYNNR 300

Query: 402 GVSP---NYPRPCQPCHCDPIGSLNEVCVKDEK--HARRGLAPGSC-HCKTGFGGVSCDR 455
              P        CQ C C+     +E C  D     A +G   G C +C+    G +C+R
Sbjct: 301 PWRPAEGQDAHECQRCDCN---GHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCER 357

Query: 456 CARGY--------TGYPDCKACNCSGLGSKNEDPC---FGPCICKENVEGGDCSRCKSGF 504
           C   Y        +    C +C C   G+    PC    G C+CKE+V+G  C  CK GF
Sbjct: 358 CQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417

Query: 505 FNLQEDNWKGCDECFCSGVSNR 526
             L   N +GC  C C+ + +R
Sbjct: 418 TGLTYANPQGCHRCDCNILGSR 439



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 57/191 (29%), Positives = 67/191 (35%), Gaps = 41/191 (21%)

Query: 1013 ACECSHLGNNCDPKTGR-------------CICPPNTIGEKCSKCAP--NTWGHSITTGC 1057
            +C C    + C PK G              C+C  NT G  C +CAP  N        G 
Sbjct: 249  SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQ 308

Query: 1058 KACNCSTVGSLDFQCNVNTGQCNCHPKF-------SGAKCTECSRGHWNYPRCNLCDCFL 1110
             A  C         CN ++  C+  P          G  C  C R H     C  C    
Sbjct: 309  DAHECQRC-----DCNGHSETCHFDPAVFAASQGAYGGVCDNC-RDHTEGKNCERCQLHY 362

Query: 1111 -----PGTD-ATTC-------DSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDA 1157
                 PG     TC       D       C   TGQC CK +V+G  CD C+PG  GL  
Sbjct: 363  FRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTY 422

Query: 1158 KNPLGCSSCYC 1168
             NP GC  C C
Sbjct: 423  ANPQGCHRCDC 433


>gi|62868215 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  200 bits (509), Expect = 2e-50
 Identities = 145/521 (27%), Positives = 225/521 (43%), Gaps = 88/521 (16%)

Query: 32  QAHQQRGLFPAV--LNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQN 89
           QA  +   +P V  L +     +  ++TCG   PE YC              Q + C  +
Sbjct: 19  QACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEW--------QMKCCKCD 70

Query: 90  SSNPNQ--RHPITNAID--GKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAAN 145
           S  P+    H + N     G   WWQS +  N      V++ LDL + FQ+  V+++   
Sbjct: 71  SRQPHNYYSHRVENVASSSGPMRWWQSQNDVNP-----VSLQLDLDRRFQLQEVMMEF-Q 124

Query: 146 SPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSK 205
            P P   ++ERS D    K W+ +     +C + +    +  P S+    +V C S   +
Sbjct: 125 GPMPAGMLIERSSDFG--KTWRVYQYLAADCTSTFPRVRQGRPQSW---QDVRCQSLPQR 179

Query: 206 IHP-LENGEIHISL---INGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261
            +  L  G++ ++L   ++G P+    S ++ E      +R+ F R+             
Sbjct: 180 PNARLNGGKVQLNLMDLVSGIPATQ--SQKIQEVGEITNLRVNFTRLA------------ 225

Query: 262 DPREIDPIVTRRY-----YYSVKDISVGGMCICYGHARACPLDPATNKSR---------C 307
                 P+  R Y     YY+V  + + G C C+GHA  C   P  +            C
Sbjct: 226 ------PVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC 279

Query: 308 ECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLN 367
            C+HNT G +C++C P ++ +PWR        EC+ C+C+G +E C++D  V   +    
Sbjct: 280 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS---- 335

Query: 368 IRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCV 427
            +G Y  GGVC NC  +T G NCE C   +FR +    +    C  C CDP G++     
Sbjct: 336 -QGAY--GGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV----- 387

Query: 428 KDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGY-----PDCKACNCSGLGSKNEDPC 482
                A      G C CK    G  CD C  G+TG        C  C+C+ LGS+ + PC
Sbjct: 388 ---PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPC 444

Query: 483 ---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
               G C+C  NV G  C +C    + L   + +GC+ C C
Sbjct: 445 DEESGRCLCLPNVVGPKCDQCAPYHWKLA--SGQGCEPCAC 483



 Score =  182 bits (463), Expect = 3e-45
 Identities = 107/328 (32%), Positives = 153/328 (46%), Gaps = 50/328 (15%)

Query: 757  CQCFGHAESCDDVTG------------ECLNCKDHTGGPYCDKCLPGFYGEPTKGT---- 800
            C C GHA+ C    G            +   C+ +T GP C++C P +   P +      
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309

Query: 801  SEDCQPCACPLNIPSNNFSPTCHLDRSL--------GLICDGCPVGYTGPRCERCAEGYF 852
            + +CQ C C      N  S TCH D ++        G +CD C     G  CERC   YF
Sbjct: 310  AHECQRCDC------NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363

Query: 853  GQPSVPGGS----CQPCQCNDNLDFSIPGS-CDSLSGSCLICKPGTTGRYCELCADGYFG 907
             +   PG S    C  C+C+   D ++PG+ CD ++G C +CK    G  C+LC  G+ G
Sbjct: 364  -RNRRPGASIQETCISCECDP--DGAVPGAPCDPVTGQC-VCKEHVQGERCDLCKPGFTG 419

Query: 908  -DAVDAKNCQPCRCNAGGSFSEV-CHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCV 965
                + + C  C CN  GS  ++ C  ++G+C C  NV G +CD+C    + L S +GC 
Sbjct: 420  LTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCE 479

Query: 966  PCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCD-----RCAHGYFNFQEGGCTACECSHL 1019
            PC C+   S S  C + +GQC C+ G  G  C      +C    +     GC AC+C   
Sbjct: 480  PCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFR 539

Query: 1020 GN---NCDPKTGRCICPPNTIGEKCSKC 1044
            G     CD  +GRC+C P   G +C +C
Sbjct: 540  GTEGPGCDKASGRCLCRPGLTGPRCDQC 567



 Score =  171 bits (433), Expect = 1e-41
 Identities = 104/324 (32%), Positives = 148/324 (45%), Gaps = 56/324 (17%)

Query: 888  ICKPGTTGRYCELCADGYFG------DAVDAKNCQPCRCNAGGSFSEVCH---------- 931
            +C+  T G  CE CA  Y        +  DA  CQ C CN     SE CH          
Sbjct: 280  VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNG---HSETCHFDPAVFAASQ 336

Query: 932  -SQTGQCE-CRANVQGQRCDKCKAGTF-----GLQSARGCVPCNCNSFGS-KSFDCEE-S 982
             +  G C+ CR + +G+ C++C+   F     G      C+ C C+  G+     C+  +
Sbjct: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVT 396

Query: 983  GQCWCQPGVTGKKCDRCAHGYFNFQEG---GCTACECSHLGNN----CDPKTGRCICPPN 1035
            GQC C+  V G++CD C  G+         GC  C+C+ LG+     CD ++GRC+C PN
Sbjct: 397  GQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPN 456

Query: 1036 TIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCT---- 1091
             +G KC +CAP  W  +   GC+ C C    SL  QCN  TGQC C   F G  C+    
Sbjct: 457  VVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAI 516

Query: 1092 -ECSRGHWN--YPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRC 1148
             +C    +      C  CDC   GT+   CD           +G+C C+  + G  CD+C
Sbjct: 517  RQCPDRTYGDVATGCRACDCDFRGTEGPGCDK---------ASGRCLCRPGLTGPRCDQC 567

Query: 1149 RPGKFGLDAKNPLGCSSCY-CFGT 1171
            + G      + P+ C +C+ CF T
Sbjct: 568  QRGYCN---RYPV-CVACHPCFQT 587



 Score =  159 bits (403), Expect = 3e-38
 Identities = 104/321 (32%), Positives = 137/321 (42%), Gaps = 44/321 (13%)

Query: 722  EVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI----CEPCQCFGHAESCD---------- 767
            +VC C     G +CE C P +         G     C+ C C GH+E+C           
Sbjct: 277  DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336

Query: 768  -DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFSPTCHL 824
                G C NC+DHT G  C++C   ++     G S  E C  C C      +   P    
Sbjct: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAPC 392

Query: 825  DRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGS-----C 879
            D   G     C     G RC+ C  G+ G        C  C CN      I GS     C
Sbjct: 393  DPVTGQCV--CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCN------ILGSRRDMPC 444

Query: 880  DSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCEC 939
            D  SG CL C P   G  C+ CA  Y       + C+PC C+   S S  C+  TGQC C
Sbjct: 445  DEESGRCL-CLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPC 502

Query: 940  RANVQGQRCD-----KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTG 993
            R    G  C      +C   T+G   A GC  C+C+  G++   C++ SG+C C+PG+TG
Sbjct: 503  REGFGGLMCSAAAIRQCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTG 561

Query: 994  KKCDRCAHGYFNFQEGGCTAC 1014
             +CD+C  GY N +   C AC
Sbjct: 562  PRCDQCQRGYCN-RYPVCVAC 581



 Score =  113 bits (282), Expect = 3e-24
 Identities = 72/213 (33%), Positives = 92/213 (43%), Gaps = 28/213 (13%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC--DPET---- 1433
            C C    +G +CE C P FY  R  P     G     C  C CNGHS  C  DP      
Sbjct: 279  CVCQHNTAGPNCERCAP-FYNNR--PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS 335

Query: 1434 -----SICQNCQHHTAGDFCERCALGYYGIVK---GLPNDCQQCACPLISSSNNFSPSCV 1485
                  +C NC+ HT G  CERC L Y+   +    +   C  C C      +   P   
Sbjct: 336  QGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAP 391

Query: 1486 AEGLDDYRCTACPRGYEGQYCERCAPGYTG-SPGNPGGSCQECECDPYGS-LPVPCDPVT 1543
             + +   +C  C    +G+ C+ C PG+TG +  NP G C  C+C+  GS   +PCD  +
Sbjct: 392  CDPVTG-QC-VCKEHVQGERCDLCKPGFTGLTYANPQG-CHRCDCNILGSRRDMPCDEES 448

Query: 1544 GFCTCRPGATGRKCDGCK--HWHAREGWECVFC 1574
            G C C P   G KCD C   HW    G  C  C
Sbjct: 449  GRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPC 481



 Score =  102 bits (254), Expect = 6e-21
 Identities = 64/167 (38%), Positives = 83/167 (49%), Gaps = 27/167 (16%)

Query: 1420 CQCNGHSSLCDPET-------------SICQNCQHHTAGDFCERCALGY----YGIVKGL 1462
            C C+GH+  C P+               +C  CQH+TAG  CERCA  Y    +   +G 
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEGQ 308

Query: 1463 -PNDCQQCACPLISSSNNFSPSCVAEGLDDYR--CTACPRGYEGQYCERCAPGYTGSPGN 1519
              ++CQ+C C   S + +F P+  A     Y   C  C    EG+ CERC   Y  +   
Sbjct: 309  DAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN-RR 367

Query: 1520 PGGSCQE----CECDPYGSLP-VPCDPVTGFCTCRPGATGRKCDGCK 1561
            PG S QE    CECDP G++P  PCDPVTG C C+    G +CD CK
Sbjct: 368  PGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 65/246 (26%), Positives = 95/246 (38%), Gaps = 58/246 (23%)

Query: 1380 CD-CPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLG-TCVPCQCNGHSSL----CDPET 1433
            CD C     G +CE C   ++R       R PG ++  TC+ C+C+   ++    CDP T
Sbjct: 343  CDNCRDHTEGKNCERCQLHYFR------NRRPGASIQETCISCECDPDGAVPGAPCDPVT 396

Query: 1434 SICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSS---------------- 1477
              C  C+ H  G+ C+ C  G+ G+    P  C +C C ++ S                 
Sbjct: 397  GQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLP 455

Query: 1478 NNFSPSC---------VAEGLDDYRCTACPRGYEGQYCER------CAPGYTG------- 1515
            N   P C         +A G     C   P       C +      C  G+ G       
Sbjct: 456  NVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA 515

Query: 1516 -------SPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREG 1568
                   + G+    C+ C+CD  G+    CD  +G C CRPG TG +CD C+  +    
Sbjct: 516  IRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRY 575

Query: 1569 WECVFC 1574
              CV C
Sbjct: 576  PVCVAC 581



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 69/259 (26%), Positives = 102/259 (39%), Gaps = 50/259 (19%)

Query: 272 RRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWR 331
           RR   S+++  +   C   G     P DP T +  C C+ +  G+ CD C PGF      
Sbjct: 366 RRPGASIQETCISCECDPDGAVPGAPCDPVTGQ--CVCKEHVQGERCDLCKPGF-----T 418

Query: 332 AGTFLTKTECEACNCH--GKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGIN 389
             T+     C  C+C+  G   +   DE   R                C+ C  N  G  
Sbjct: 419 GLTYANPQGCHRCDCNILGSRRDMPCDEESGR----------------CL-CLPNVVGPK 461

Query: 390 CETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449
           C+ C    ++         + C+PC CDP  SL+  C +           G C C+ GFG
Sbjct: 462 CDQCAPYHWKLAS-----GQGCEPCACDPHNSLSPQCNQ---------FTGQCPCREGFG 507

Query: 450 GVSCDRCA------RGYTGYPD-CKACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRC 500
           G+ C   A      R Y      C+AC+C   G++    D   G C+C+  + G  C +C
Sbjct: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC 567

Query: 501 KSGFFNLQEDNWKGCDECF 519
           + G+ N +      C  CF
Sbjct: 568 QRGYCN-RYPVCVACHPCF 585



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 62/202 (30%), Positives = 88/202 (43%), Gaps = 29/202 (14%)

Query: 343 ACNCHGKAEECYYDENV-ARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPK 401
           +C CHG A+ C       A  + ++ +        VC+ C  NTAG NCE C   F+  +
Sbjct: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHD------VCV-CQHNTAGPNCERCAP-FYNNR 300

Query: 402 GVSP---NYPRPCQPCHCDPIGSLNEVCVKDEK--HARRGLAPGSC-HCKTGFGGVSCDR 455
              P        CQ C C+     +E C  D     A +G   G C +C+    G +C+R
Sbjct: 301 PWRPAEGQDAHECQRCDCN---GHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCER 357

Query: 456 CARGY--------TGYPDCKACNCSGLGSKNEDPC---FGPCICKENVEGGDCSRCKSGF 504
           C   Y        +    C +C C   G+    PC    G C+CKE+V+G  C  CK GF
Sbjct: 358 CQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417

Query: 505 FNLQEDNWKGCDECFCSGVSNR 526
             L   N +GC  C C+ + +R
Sbjct: 418 TGLTYANPQGCHRCDCNILGSR 439



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 57/191 (29%), Positives = 67/191 (35%), Gaps = 41/191 (21%)

Query: 1013 ACECSHLGNNCDPKTGR-------------CICPPNTIGEKCSKCAP--NTWGHSITTGC 1057
            +C C    + C PK G              C+C  NT G  C +CAP  N        G 
Sbjct: 249  SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQ 308

Query: 1058 KACNCSTVGSLDFQCNVNTGQCNCHPKF-------SGAKCTECSRGHWNYPRCNLCDCFL 1110
             A  C         CN ++  C+  P          G  C  C R H     C  C    
Sbjct: 309  DAHECQRC-----DCNGHSETCHFDPAVFAASQGAYGGVCDNC-RDHTEGKNCERCQLHY 362

Query: 1111 -----PGTD-ATTC-------DSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDA 1157
                 PG     TC       D       C   TGQC CK +V+G  CD C+PG  GL  
Sbjct: 363  FRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTY 422

Query: 1158 KNPLGCSSCYC 1168
             NP GC  C C
Sbjct: 423  ANPQGCHRCDC 433


>gi|189083719 laminin, beta 3 precursor [Homo sapiens]
          Length = 1172

 Score =  200 bits (509), Expect = 2e-50
 Identities = 145/521 (27%), Positives = 225/521 (43%), Gaps = 88/521 (16%)

Query: 32  QAHQQRGLFPAV--LNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQN 89
           QA  +   +P V  L +     +  ++TCG   PE YC              Q + C  +
Sbjct: 19  QACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEW--------QMKCCKCD 70

Query: 90  SSNPNQ--RHPITNAID--GKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAAN 145
           S  P+    H + N     G   WWQS +  N      V++ LDL + FQ+  V+++   
Sbjct: 71  SRQPHNYYSHRVENVASSSGPMRWWQSQNDVNP-----VSLQLDLDRRFQLQEVMMEF-Q 124

Query: 146 SPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSK 205
            P P   ++ERS D    K W+ +     +C + +    +  P S+    +V C S   +
Sbjct: 125 GPMPAGMLIERSSDFG--KTWRVYQYLAADCTSTFPRVRQGRPQSW---QDVRCQSLPQR 179

Query: 206 IHP-LENGEIHISL---INGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261
            +  L  G++ ++L   ++G P+    S ++ E      +R+ F R+             
Sbjct: 180 PNARLNGGKVQLNLMDLVSGIPATQ--SQKIQEVGEITNLRVNFTRLA------------ 225

Query: 262 DPREIDPIVTRRY-----YYSVKDISVGGMCICYGHARACPLDPATNKSR---------C 307
                 P+  R Y     YY+V  + + G C C+GHA  C   P  +            C
Sbjct: 226 ------PVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC 279

Query: 308 ECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLN 367
            C+HNT G +C++C P ++ +PWR        EC+ C+C+G +E C++D  V   +    
Sbjct: 280 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS---- 335

Query: 368 IRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCV 427
            +G Y  GGVC NC  +T G NCE C   +FR +    +    C  C CDP G++     
Sbjct: 336 -QGAY--GGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAV----- 387

Query: 428 KDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGY-----PDCKACNCSGLGSKNEDPC 482
                A      G C CK    G  CD C  G+TG        C  C+C+ LGS+ + PC
Sbjct: 388 ---PGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPC 444

Query: 483 ---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
               G C+C  NV G  C +C    + L   + +GC+ C C
Sbjct: 445 DEESGRCLCLPNVVGPKCDQCAPYHWKLA--SGQGCEPCAC 483



 Score =  182 bits (463), Expect = 3e-45
 Identities = 107/328 (32%), Positives = 153/328 (46%), Gaps = 50/328 (15%)

Query: 757  CQCFGHAESCDDVTG------------ECLNCKDHTGGPYCDKCLPGFYGEPTKGT---- 800
            C C GHA+ C    G            +   C+ +T GP C++C P +   P +      
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQD 309

Query: 801  SEDCQPCACPLNIPSNNFSPTCHLDRSL--------GLICDGCPVGYTGPRCERCAEGYF 852
            + +CQ C C      N  S TCH D ++        G +CD C     G  CERC   YF
Sbjct: 310  AHECQRCDC------NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYF 363

Query: 853  GQPSVPGGS----CQPCQCNDNLDFSIPGS-CDSLSGSCLICKPGTTGRYCELCADGYFG 907
             +   PG S    C  C+C+   D ++PG+ CD ++G C +CK    G  C+LC  G+ G
Sbjct: 364  -RNRRPGASIQETCISCECDP--DGAVPGAPCDPVTGQC-VCKEHVQGERCDLCKPGFTG 419

Query: 908  -DAVDAKNCQPCRCNAGGSFSEV-CHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCV 965
                + + C  C CN  GS  ++ C  ++G+C C  NV G +CD+C    + L S +GC 
Sbjct: 420  LTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCE 479

Query: 966  PCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCD-----RCAHGYFNFQEGGCTACECSHL 1019
            PC C+   S S  C + +GQC C+ G  G  C      +C    +     GC AC+C   
Sbjct: 480  PCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFR 539

Query: 1020 GN---NCDPKTGRCICPPNTIGEKCSKC 1044
            G     CD  +GRC+C P   G +C +C
Sbjct: 540  GTEGPGCDKASGRCLCRPGLTGPRCDQC 567



 Score =  171 bits (433), Expect = 1e-41
 Identities = 104/324 (32%), Positives = 148/324 (45%), Gaps = 56/324 (17%)

Query: 888  ICKPGTTGRYCELCADGYFG------DAVDAKNCQPCRCNAGGSFSEVCH---------- 931
            +C+  T G  CE CA  Y        +  DA  CQ C CN     SE CH          
Sbjct: 280  VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNG---HSETCHFDPAVFAASQ 336

Query: 932  -SQTGQCE-CRANVQGQRCDKCKAGTF-----GLQSARGCVPCNCNSFGS-KSFDCEE-S 982
             +  G C+ CR + +G+ C++C+   F     G      C+ C C+  G+     C+  +
Sbjct: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVT 396

Query: 983  GQCWCQPGVTGKKCDRCAHGYFNFQEG---GCTACECSHLGNN----CDPKTGRCICPPN 1035
            GQC C+  V G++CD C  G+         GC  C+C+ LG+     CD ++GRC+C PN
Sbjct: 397  GQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPN 456

Query: 1036 TIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCT---- 1091
             +G KC +CAP  W  +   GC+ C C    SL  QCN  TGQC C   F G  C+    
Sbjct: 457  VVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAI 516

Query: 1092 -ECSRGHWN--YPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRC 1148
             +C    +      C  CDC   GT+   CD           +G+C C+  + G  CD+C
Sbjct: 517  RQCPDRTYGDVATGCRACDCDFRGTEGPGCDK---------ASGRCLCRPGLTGPRCDQC 567

Query: 1149 RPGKFGLDAKNPLGCSSCY-CFGT 1171
            + G      + P+ C +C+ CF T
Sbjct: 568  QRGYCN---RYPV-CVACHPCFQT 587



 Score =  159 bits (403), Expect = 3e-38
 Identities = 104/321 (32%), Positives = 137/321 (42%), Gaps = 44/321 (13%)

Query: 722  EVCQCPPGYTGSSCESCWPRHRRVNGTIFGGI----CEPCQCFGHAESCD---------- 767
            +VC C     G +CE C P +         G     C+ C C GH+E+C           
Sbjct: 277  DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQ 336

Query: 768  -DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFSPTCHL 824
                G C NC+DHT G  C++C   ++     G S  E C  C C      +   P    
Sbjct: 337  GAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAPC 392

Query: 825  DRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGS-----C 879
            D   G     C     G RC+ C  G+ G        C  C CN      I GS     C
Sbjct: 393  DPVTGQCV--CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCN------ILGSRRDMPC 444

Query: 880  DSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCEC 939
            D  SG CL C P   G  C+ CA  Y       + C+PC C+   S S  C+  TGQC C
Sbjct: 445  DEESGRCL-CLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPC 502

Query: 940  RANVQGQRCD-----KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTG 993
            R    G  C      +C   T+G   A GC  C+C+  G++   C++ SG+C C+PG+TG
Sbjct: 503  REGFGGLMCSAAAIRQCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTG 561

Query: 994  KKCDRCAHGYFNFQEGGCTAC 1014
             +CD+C  GY N +   C AC
Sbjct: 562  PRCDQCQRGYCN-RYPVCVAC 581



 Score =  113 bits (282), Expect = 3e-24
 Identities = 72/213 (33%), Positives = 92/213 (43%), Gaps = 28/213 (13%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLC--DPET---- 1433
            C C    +G +CE C P FY  R  P     G     C  C CNGHS  C  DP      
Sbjct: 279  CVCQHNTAGPNCERCAP-FYNNR--PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAAS 335

Query: 1434 -----SICQNCQHHTAGDFCERCALGYYGIVK---GLPNDCQQCACPLISSSNNFSPSCV 1485
                  +C NC+ HT G  CERC L Y+   +    +   C  C C      +   P   
Sbjct: 336  QGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCEC----DPDGAVPGAP 391

Query: 1486 AEGLDDYRCTACPRGYEGQYCERCAPGYTG-SPGNPGGSCQECECDPYGS-LPVPCDPVT 1543
             + +   +C  C    +G+ C+ C PG+TG +  NP G C  C+C+  GS   +PCD  +
Sbjct: 392  CDPVTG-QC-VCKEHVQGERCDLCKPGFTGLTYANPQG-CHRCDCNILGSRRDMPCDEES 448

Query: 1544 GFCTCRPGATGRKCDGCK--HWHAREGWECVFC 1574
            G C C P   G KCD C   HW    G  C  C
Sbjct: 449  GRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPC 481



 Score =  102 bits (254), Expect = 6e-21
 Identities = 64/167 (38%), Positives = 83/167 (49%), Gaps = 27/167 (16%)

Query: 1420 CQCNGHSSLCDPET-------------SICQNCQHHTAGDFCERCALGY----YGIVKGL 1462
            C C+GH+  C P+               +C  CQH+TAG  CERCA  Y    +   +G 
Sbjct: 250  CFCHGHADRCAPKPGASAGPSTAVQVHDVCV-CQHNTAGPNCERCAPFYNNRPWRPAEGQ 308

Query: 1463 -PNDCQQCACPLISSSNNFSPSCVAEGLDDYR--CTACPRGYEGQYCERCAPGYTGSPGN 1519
              ++CQ+C C   S + +F P+  A     Y   C  C    EG+ CERC   Y  +   
Sbjct: 309  DAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN-RR 367

Query: 1520 PGGSCQE----CECDPYGSLP-VPCDPVTGFCTCRPGATGRKCDGCK 1561
            PG S QE    CECDP G++P  PCDPVTG C C+    G +CD CK
Sbjct: 368  PGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCK 414



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 65/246 (26%), Positives = 95/246 (38%), Gaps = 58/246 (23%)

Query: 1380 CD-CPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLG-TCVPCQCNGHSSL----CDPET 1433
            CD C     G +CE C   ++R       R PG ++  TC+ C+C+   ++    CDP T
Sbjct: 343  CDNCRDHTEGKNCERCQLHYFR------NRRPGASIQETCISCECDPDGAVPGAPCDPVT 396

Query: 1434 SICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSS---------------- 1477
              C  C+ H  G+ C+ C  G+ G+    P  C +C C ++ S                 
Sbjct: 397  GQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLP 455

Query: 1478 NNFSPSC---------VAEGLDDYRCTACPRGYEGQYCER------CAPGYTG------- 1515
            N   P C         +A G     C   P       C +      C  G+ G       
Sbjct: 456  NVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAA 515

Query: 1516 -------SPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREG 1568
                   + G+    C+ C+CD  G+    CD  +G C CRPG TG +CD C+  +    
Sbjct: 516  IRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRY 575

Query: 1569 WECVFC 1574
              CV C
Sbjct: 576  PVCVAC 581



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 69/259 (26%), Positives = 102/259 (39%), Gaps = 50/259 (19%)

Query: 272 RRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWR 331
           RR   S+++  +   C   G     P DP T +  C C+ +  G+ CD C PGF      
Sbjct: 366 RRPGASIQETCISCECDPDGAVPGAPCDPVTGQ--CVCKEHVQGERCDLCKPGF-----T 418

Query: 332 AGTFLTKTECEACNCH--GKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGIN 389
             T+     C  C+C+  G   +   DE   R                C+ C  N  G  
Sbjct: 419 GLTYANPQGCHRCDCNILGSRRDMPCDEESGR----------------CL-CLPNVVGPK 461

Query: 390 CETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFG 449
           C+ C    ++         + C+PC CDP  SL+  C +           G C C+ GFG
Sbjct: 462 CDQCAPYHWKLAS-----GQGCEPCACDPHNSLSPQCNQ---------FTGQCPCREGFG 507

Query: 450 GVSCDRCA------RGYTGYPD-CKACNCSGLGSKNE--DPCFGPCICKENVEGGDCSRC 500
           G+ C   A      R Y      C+AC+C   G++    D   G C+C+  + G  C +C
Sbjct: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC 567

Query: 501 KSGFFNLQEDNWKGCDECF 519
           + G+ N +      C  CF
Sbjct: 568 QRGYCN-RYPVCVACHPCF 585



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 62/202 (30%), Positives = 88/202 (43%), Gaps = 29/202 (14%)

Query: 343 ACNCHGKAEECYYDENV-ARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPK 401
           +C CHG A+ C       A  + ++ +        VC+ C  NTAG NCE C   F+  +
Sbjct: 249 SCFCHGHADRCAPKPGASAGPSTAVQVHD------VCV-CQHNTAGPNCERCAP-FYNNR 300

Query: 402 GVSP---NYPRPCQPCHCDPIGSLNEVCVKDEK--HARRGLAPGSC-HCKTGFGGVSCDR 455
              P        CQ C C+     +E C  D     A +G   G C +C+    G +C+R
Sbjct: 301 PWRPAEGQDAHECQRCDCN---GHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCER 357

Query: 456 CARGY--------TGYPDCKACNCSGLGSKNEDPC---FGPCICKENVEGGDCSRCKSGF 504
           C   Y        +    C +C C   G+    PC    G C+CKE+V+G  C  CK GF
Sbjct: 358 CQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGF 417

Query: 505 FNLQEDNWKGCDECFCSGVSNR 526
             L   N +GC  C C+ + +R
Sbjct: 418 TGLTYANPQGCHRCDCNILGSR 439



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 57/191 (29%), Positives = 67/191 (35%), Gaps = 41/191 (21%)

Query: 1013 ACECSHLGNNCDPKTGR-------------CICPPNTIGEKCSKCAP--NTWGHSITTGC 1057
            +C C    + C PK G              C+C  NT G  C +CAP  N        G 
Sbjct: 249  SCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQ 308

Query: 1058 KACNCSTVGSLDFQCNVNTGQCNCHPKF-------SGAKCTECSRGHWNYPRCNLCDCFL 1110
             A  C         CN ++  C+  P          G  C  C R H     C  C    
Sbjct: 309  DAHECQRC-----DCNGHSETCHFDPAVFAASQGAYGGVCDNC-RDHTEGKNCERCQLHY 362

Query: 1111 -----PGTD-ATTC-------DSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDA 1157
                 PG     TC       D       C   TGQC CK +V+G  CD C+PG  GL  
Sbjct: 363  FRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTY 422

Query: 1158 KNPLGCSSCYC 1168
             NP GC  C C
Sbjct: 423  ANPQGCHRCDC 433


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  194 bits (494), Expect = 9e-49
 Identities = 163/544 (29%), Positives = 210/544 (38%), Gaps = 125/544 (22%)

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGP 783
            C+CPPG TG  CE+  P  R   G     IC  CQ   HA  CD  TG CL      G  
Sbjct: 758  CRCPPGRTGEDCEADCPEGRWGLGC--QEICPACQ---HAARCDPETGACLCLPGFVGSR 812

Query: 784  YCDKCLPGFYGEPTK-----GTSEDCQP------CA-------CPLNIPSNNFSPTCHLD 825
              D C  G+YG   +          C P      CA       C     + ++ P C   
Sbjct: 813  CQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHP 872

Query: 826  RSLGL---ICDG------CPVGYTGPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSI 875
             +       CD       C  GY GPRCE+ C +G+FG      G  Q CQC        
Sbjct: 873  CNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGP-----GCEQRCQCQHG----- 922

Query: 876  PGSCDSLSGSCLICKPGTTGRYCE-LCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQT 934
              +CD +SG+C  C  G  G +CE  C  G+FG  +D ++   C C AG +    C +  
Sbjct: 923  -AACDHVSGACT-CPAGWRGTFCEHACPAGFFG--LDCRSA--CNCTAGAA----CDAVN 972

Query: 935  GQCECRANVQGQRC-DKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTG 993
            G C C A  +G RC + C A T+G   ++ C       F   S D    GQC C PG  G
Sbjct: 973  GSCLCPAGRRGPRCAETCPAHTYGHNCSQACA-----CFNGASCD-PVHGQCHCAPGWMG 1026

Query: 994  KKC----------DRCAHGYFNFQEGGCT---------------ACE-----------CS 1017
              C          D C H       G C                ACE           C 
Sbjct: 1027 PSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCR 1086

Query: 1018 HLGNN-----CDPKTGRCICPPNTIGEKC-SKCAPNTWGHSITTGCKACNCSTVGSLDFQ 1071
            H G       CDP TGRC+CP    G+KC S C    +G +     + C+C    +    
Sbjct: 1087 HSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEAC---AQRCSCPPGAA---- 1139

Query: 1072 CNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQ 1130
            C+  TG C C P F+G+ C + C  G +      +C C  PG +           +C   
Sbjct: 1140 CHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQC--PGENP----------ACHPA 1187

Query: 1131 TGQCTCKVNVEGIHC-DRCRPGKFGLDAKNPLGC-SSCYCFGTTTQCSEAKGLIRTWVTL 1188
            TG C+C     G  C  RC PG++G   +   GC +   C   T  C    G + T   L
Sbjct: 1188 TGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNL 1247

Query: 1189 KAEQ 1192
               Q
Sbjct: 1248 TCPQ 1251



 Score =  186 bits (471), Expect = 4e-46
 Identities = 251/979 (25%), Positives = 337/979 (34%), Gaps = 256/979 (26%)

Query: 320  QCCPGFHQKPWRAGTFLTKTECEACNC-HG-----------------KAEECYYDENVAR 361
            +CC G+ Q+P   G      EC A  C HG                 +   C YD +  R
Sbjct: 109  RCCRGWMQQPDEEGCL--SAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECR 166

Query: 362  ------RNLSLNIRGKYI---GGGVCINCTQNTA-GINCETCTDGFFRPKGVSPNYPRPC 411
                  ++  +N  G Y+     G  ++    T   IN     +G  +   V     R  
Sbjct: 167  THNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITR-- 224

Query: 412  QPCHCDPIGSLNEV---CVKDEKHARRGLAPGSC--HCKTGFGGVSCDRCARGYTGYPDC 466
              C C P   L E    CV+    A R    GSC   C+   G   C+ C  GY    D 
Sbjct: 225  HRCQCRPGFQLQEDGRHCVRRSPCANRN---GSCMHRCQVVRGLARCE-CHVGYQLAADG 280

Query: 467  KACN-----CSGL-----GSKNEDPCFGPCICKENVE----GGDCSRCKSGFFNLQEDNW 512
            KAC       +GL     G  N    F  C+C    E    G  C R +    N  E N 
Sbjct: 281  KACEDVDECAAGLAQCAHGCLNTQGSF-KCVCHAGYELGADGRQCYRIEMEIVNSCEANN 339

Query: 513  KGCDECFCSGVSNRCQSSYWTYGKIQDMSGWYLTDLPGRIRVAPQQDDLDSP--QQISIS 570
             GC        S+ C  S+ + G +      Y  D   R  +    D  DSP  QQ+  +
Sbjct: 340  GGC--------SHGC--SHTSAGPLCTCPRGYELDTDQRTCI-DVDDCADSPCCQQVCTN 388

Query: 571  NAEARQALPHSYYWSAPAPYLGNKLPAVGG--------------------------QLTF 604
            N       P  Y       Y G +L A G                           Q + 
Sbjct: 389  N-------PGGYECGC---YAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSC 438

Query: 605  TISYDLEEEEEDTERVLQLMIILEGNDL------SISTAQDEVYLHPSEEHTNVLLLKEE 658
               Y L E+      + + M+ L+G          I+  QDE+   P     + +   EE
Sbjct: 439  EAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDEL---PQLFQDDDVGADEE 495

Query: 659  SFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIA 718
               + G H              L    + +  SFG D                   G+  
Sbjct: 496  EAELRGEH-------------TLTEKFVCLDDSFGHDCSLTCDDCR--------NGGTCL 534

Query: 719  AAVEVCQCPPGYTGSSC-ESCWPRHRRVNGTIFGGICE-PCQCFGHAESCDDVTGECLNC 776
              ++ C CP G+TG  C E+C P         FG  C   C C  +  +CD VTG C  C
Sbjct: 535  LGLDGCDCPEGWTGLICNETCPP-------DTFGKNCSFSCSC-QNGGTCDSVTGAC-RC 585

Query: 777  KDHTGGPYC-DKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSL-GLICD- 833
                 G  C D C  G+YG+  +      + C C      +     C  D  L G  C  
Sbjct: 586  PPGVSGTNCEDGCPKGYYGKHCR------KKCNCANRGRCHRLYGACLCDPGLYGRFCHL 639

Query: 834  GCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGT 893
             CP    GP C                  + CQC          SCD   GSC  CK G 
Sbjct: 640  TCPPWAFGPGCS-----------------EECQCVQ----PHTQSCDKRDGSCS-CKAGF 677

Query: 894  TGRYCEL-CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQC--ECRANVQGQRC-D 949
             G  C+  C  GYFG        Q C C  G +    C S +G+C   C A  QG+ C  
Sbjct: 678  RGERCQAECELGYFGPGC----WQACTCPVGVA----CDSVSGECGKRCPAGFQGEDCGQ 729

Query: 950  KCKAGTFGLQSARGC----VPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDR-CAHGYF 1004
            +C  GTFG+  +  C     PC+             +GQC C PG TG+ C+  C  G +
Sbjct: 730  ECPVGTFGVNCSSSCSCGGAPCH-----------GVTGQCRCPPGRTGEDCEADCPEGRW 778

Query: 1005 NFQEGGCTA-CECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTW-GHSITTGCKACNC 1062
                 GC   C        CDP+TG C+C P  +G +C    P  W G S  T C   N 
Sbjct: 779  GL---GCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCAN- 834

Query: 1063 STVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRCNLCDCFLPGTDATTCDSE 1121
                  D  C+  TG C+C P ++G  C   C  GHW     + C+C        +CD+ 
Sbjct: 835  ------DGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNC---SAGHGSCDAI 885

Query: 1122 TKKC----------------------------------SCSDQTGQCTCKVNVEGIHCDR 1147
            +  C                                  +C   +G CTC     G  C+ 
Sbjct: 886  SGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEH 945

Query: 1148 -CRPGKFGLDAKNPLGCSS 1165
             C  G FGLD ++   C++
Sbjct: 946  ACPAGFFGLDCRSACNCTA 964



 Score =  179 bits (454), Expect = 4e-44
 Identities = 138/439 (31%), Positives = 182/439 (41%), Gaps = 78/439 (17%)

Query: 710  SYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDV 769
            S P   +       C+CPPG+TGS CE   P      G+      + CQC G   +C   
Sbjct: 1133 SCPPGAACHHVTGACRCPPGFTGSGCEQACP-----PGSFGEDCAQMCQCPGENPACHPA 1187

Query: 770  TGECLNCKDHTGGPYC-DKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSL 828
            TG C +C     GP C  +C PG YG   +      Q C C      +  +  C      
Sbjct: 1188 TGTC-SCAAGYHGPSCQQRCPPGRYGPGCE------QLCGCLNGGSCDAATGACR----- 1235

Query: 829  GLICDGCPVGYTGPRCE-RCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCL 887
                  CP G+ G  C   C +G FG           C C          +CD ++G+CL
Sbjct: 1236 ------CPTGFLGTDCNLTCPQGRFGP-----NCTHVCGCGQG------AACDPVTGTCL 1278

Query: 888  ICKPGTTGRYCEL-CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQ 946
             C PG  G  CE  C    FG   +      C C  GG    +CH+  G C C     G+
Sbjct: 1279 -CPPGRAGVRCERGCPQNRFGVGCE----HTCSCRNGG----LCHASNGSCSCGLGWTGR 1329

Query: 947  RCD-KCKAGTFGLQSARGCVPCNCNSFGSKSFDCE-ESGQCWCQPGVTGKKCDR-CAHGY 1003
             C+  C  G +G   A   + C+C++    +  CE  +G C C PG  G+ C+  C  G 
Sbjct: 1330 HCELACPPGRYG---AACHLECSCHN----NSTCEPATGTCRCGPGFYGQACEHPCPPG- 1381

Query: 1004 FNFQEGGCTA-CECSHLGNNCDPKTGRCICPPNTIGEKCSK-CAPNTWGHSITTGC-KAC 1060
              F   GC   C C H G  CDP +GRC+CP    G  C + C P ++G     GC + C
Sbjct: 1382 --FHGAGCQGLCWCQH-GAPCDPISGRCLCPAGFHGHFCERGCEPGSFGE----GCHQRC 1434

Query: 1061 NCSTVGSLDFQCNVNTGQCNCHPKFSGAKCT-ECSRGHWNYPRCNL-CDCFLPGTDATTC 1118
            +C         C+  TG C C P  SGA C  +C RG +  P C L CDC         C
Sbjct: 1435 DCDG----GAPCDPVTGLCLCPPGRSGATCNLDCRRGQFG-PSCTLHCDC----GGGADC 1485

Query: 1119 DSETKKCSCSDQTGQCTCK 1137
            D  + +C C D     TC+
Sbjct: 1486 DPVSGQCHCVDGYMGPTCR 1504



 Score =  173 bits (438), Expect = 3e-42
 Identities = 162/545 (29%), Positives = 211/545 (38%), Gaps = 135/545 (24%)

Query: 713  TDGSIAAAVE-VCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC-EPCQCFGHAESCDDVT 770
            T G+   AV   C CP G  G  C    P H       +G  C + C CF  A SCD V 
Sbjct: 963  TAGAACDAVNGSCLCPAGRRGPRCAETCPAHT------YGHNCSQACACFNGA-SCDPVH 1015

Query: 771  GECLNCKDHTGGPYC-DKCLPGFYGEPTKGT-----SEDCQP----CACPLN-------- 812
            G+C +C     GP C   C  G YG+  + +        C P    CACP          
Sbjct: 1016 GQC-HCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEK 1074

Query: 813  --IPSNNFSPTCHLDRSL-GLICDG------CPVGYTGPRCER-CAEGYFGQPSVPGGSC 862
              +P +  +   H    L G +CD       CP G+TG +C+  C  G+FG+      SC
Sbjct: 1075 ECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSC 1134

Query: 863  QPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCE-LCADGYFGDAVDAKNCQPCRCN 921
             P             +C  ++G+C  C PG TG  CE  C  G FG+       Q C+C 
Sbjct: 1135 PP-----------GAACHHVTGACR-CPPGFTGSGCEQACPPGSFGEDC----AQMCQCP 1178

Query: 922  AGGSFSEVCHSQTGQCECRANVQGQRCD-KCKAGTFGLQSARGCVP-CNCNSFGSKSFDC 979
                 +  CH  TG C C A   G  C  +C  G +G     GC   C C + GS    C
Sbjct: 1179 GE---NPACHPATGTCSCAAGYHGPSCQQRCPPGRYG----PGCEQLCGCLNGGS----C 1227

Query: 980  EES-GQCWCQPGVTGKKCD-RCAHGYFNFQEGGCT-ACECSHLGNNCDPKTGRCICPPNT 1036
            + + G C C  G  G  C+  C  G F      CT  C C   G  CDP TG C+CPP  
Sbjct: 1228 DAATGACRCPTGFLGTDCNLTCPQGRFG---PNCTHVCGCGQ-GAACDPVTGTCLCPPGR 1283

Query: 1037 IGEKCSK-CAPNTWGHSITTGCK-ACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKC-TEC 1093
             G +C + C  N +G     GC+  C+C   G     C+ + G C+C   ++G  C   C
Sbjct: 1284 AGVRCERGCPQNRFG----VGCEHTCSCRNGG----LCHASNGSCSCGLGWTGRHCELAC 1335

Query: 1094 SRGHWNYPRCNL-CDCFLPGTDATTCDSETKKCSCSDQ---------------------- 1130
              G +    C+L C C     + +TC+  T  C C                         
Sbjct: 1336 PPGRYG-AACHLECSCH----NNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGL 1390

Query: 1131 ------------TGQCTCKVNVEGIHCDR-CRPGKFGLDAKNPLGC-SSCYCFGTTTQCS 1176
                        +G+C C     G  C+R C PG FG       GC   C C G    C 
Sbjct: 1391 CWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFG------EGCHQRCDCDG-GAPCD 1443

Query: 1177 EAKGL 1181
               GL
Sbjct: 1444 PVTGL 1448



 Score = 99.8 bits (247), Expect = 4e-20
 Identities = 81/283 (28%), Positives = 110/283 (38%), Gaps = 41/283 (14%)

Query: 900  LCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK-CKAGTFGL 958
            +C D  FG       C  CR N G      C      C+C     G  C++ C   TFG 
Sbjct: 510  VCLDDSFGHDCSL-TCDDCR-NGG-----TCLLGLDGCDCPEGWTGLICNETCPPDTFGK 562

Query: 959  QSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTA-CE 1015
              +     C+C + G+    C+  +G C C PGV+G  C D C  GY+      C   C 
Sbjct: 563  NCS---FSCSCQNGGT----CDSVTGACRCPPGVSGTNCEDGCPKGYYGKH---CRKKCN 612

Query: 1016 CSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCNV 1074
            C++ G  C    G C+C P   G  C   C P  +G     GC    C  V      C+ 
Sbjct: 613  CANRGR-CHRLYGACLCDPGLYGRFCHLTCPPWAFG----PGCSE-ECQCVQPHTQSCDK 666

Query: 1075 NTGQCNCHPKFSGAKC-TECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQ 1133
              G C+C   F G +C  EC  G++       C C +       CDS + +C        
Sbjct: 667  RDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPV----GVACDSVSGECGKR----- 717

Query: 1134 CTCKVNVEGIHCDR-CRPGKFGLDAKNPLGCSSCYCFGTTTQC 1175
              C    +G  C + C  G FG++  +   C    C G T QC
Sbjct: 718  --CPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQC 758



 Score = 91.7 bits (226), Expect = 1e-17
 Identities = 76/250 (30%), Positives = 95/250 (38%), Gaps = 49/250 (19%)

Query: 703  VNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICE-PCQCFG 761
            V  E   S    G   A+   C C  G+TG  CE   P  R      +G  C   C C  
Sbjct: 1299 VGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGR------YGAACHLECSCHN 1352

Query: 762  HAESCDDVTGECLNCKDHTGGPYCD-KCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSP 820
            ++ +C+  TG C  C     G  C+  C PGF+G   +G       C C    P +  S 
Sbjct: 1353 NS-TCEPATGTC-RCGPGFYGQACEHPCPPGFHGAGCQGL------CWCQHGAPCDPISG 1404

Query: 821  TCHLDRSLGLICDGCPVGYTGPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSC 879
             C            CP G+ G  CER C  G FG+     G  Q C C+          C
Sbjct: 1405 RCL-----------CPAGFHGHFCERGCEPGSFGE-----GCHQRCDCDGG------APC 1442

Query: 880  DSLSGSCLICKPGTTGRYCEL-CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCE 938
            D ++G CL C PG +G  C L C  G FG +        C C  G      C   +GQC 
Sbjct: 1443 DPVTGLCL-CPPGRSGATCNLDCRRGQFGPSCTLH----CDCGGGAD----CDPVSGQCH 1493

Query: 939  CRANVQGQRC 948
            C     G  C
Sbjct: 1494 CVDGYMGPTC 1503



 Score = 87.0 bits (214), Expect = 3e-16
 Identities = 62/184 (33%), Positives = 79/184 (42%), Gaps = 47/184 (25%)

Query: 1380 CDCPLGYSGLSCE-ACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHS-SLCDPETSICQ 1437
            C C LG++G  CE AC PG Y               G     +C+ H+ S C+P T  C+
Sbjct: 1320 CSCGLGWTGRHCELACPPGRY---------------GAACHLECSCHNNSTCEPATGTCR 1364

Query: 1438 NCQHHTAGDFCER-CALGYYGIVKGLPNDCQQ-CACPLISSSNNFSPSCVAEGLDDYRCT 1495
             C     G  CE  C  G++G        CQ  C C   +  +  S  C+          
Sbjct: 1365 -CGPGFYGQACEHPCPPGFHGA------GCQGLCWCQHGAPCDPISGRCL---------- 1407

Query: 1496 ACPRGYEGQYCER-CAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATG 1554
             CP G+ G +CER C PG  G      G  Q C+CD       PCDPVTG C C PG +G
Sbjct: 1408 -CPAGFHGHFCERGCEPGSFGE-----GCHQRCDCDG----GAPCDPVTGLCLCPPGRSG 1457

Query: 1555 RKCD 1558
              C+
Sbjct: 1458 ATCN 1461



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 63/214 (29%), Positives = 78/214 (36%), Gaps = 53/214 (24%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVP-CQCNGHSSLCDPETSICQN 1438
            C CP G++G  CE   P             PG     C   CQC G +  C P T  C +
Sbjct: 1147 CRCPPGFTGSGCEQACP-------------PGSFGEDCAQMCQCPGENPACHPATGTC-S 1192

Query: 1439 CQHHTAGDFCE-RCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
            C     G  C+ RC  G YG     P   Q C C    S +  + +C            C
Sbjct: 1193 CAAGYHGPSCQQRCPPGRYG-----PGCEQLCGCLNGGSCDAATGAC-----------RC 1236

Query: 1498 PRGYEGQYCERCAPGYTGSPGNPGGSCQE-CECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556
            P G+ G  C    P      G  G +C   C C    +    CDPVTG C C PG  G +
Sbjct: 1237 PTGFLGTDCNLTCP-----QGRFGPNCTHVCGCGQGAA----CDPVTGTCLCPPGRAGVR 1287

Query: 1557 CD----------GCKH-WHAREGWECVFCGDECT 1579
            C+          GC+H    R G  C      C+
Sbjct: 1288 CERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCS 1321



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 65/219 (29%), Positives = 83/219 (37%), Gaps = 56/219 (25%)

Query: 1367 GTTMTPPADLIEKCD--CPLGYSGLSCE----------------ACL--PGFY----RLR 1402
            G    PP      C+  CP GY G  C                 ACL  PG Y     L 
Sbjct: 581  GACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLT 640

Query: 1403 SQPGGRTPGPTLGTCVPCQC-NGHSSLCDPETSICQNCQHHTAGDFCE-RCALGYYGIVK 1460
              P    PG +      CQC   H+  CD     C +C+    G+ C+  C LGY+G   
Sbjct: 641  CPPWAFGPGCS----EECQCVQPHTQSCDKRDGSC-SCKAGFRGERCQAECELGYFG--- 692

Query: 1461 GLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNP 1520
              P   Q C CP+  + ++ S  C            CP G++G+ C +  P      G  
Sbjct: 693  --PGCWQACTCPVGVACDSVSGECGKR---------CPAGFQGEDCGQECP-----VGTF 736

Query: 1521 GGSCQE-CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558
            G +C   C C        PC  VTG C C PG TG  C+
Sbjct: 737  GVNCSSSCSCGG-----APCHGVTGQCRCPPGRTGEDCE 770



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 68/218 (31%), Positives = 87/218 (39%), Gaps = 55/218 (25%)

Query: 1367 GTTMTPPADLIEKC--DCPLGYSGLSCEA-------------------CLPGFYRLRSQ- 1404
            G    PP    E C  DCP G  GL C+                    CLPGF   R Q 
Sbjct: 756  GQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQD 815

Query: 1405 --PGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAGDFCER-CALGYYGIVKG 1461
              P G   GP+  T   C  +GH   C P T  C +C     G  C+R C  G++G    
Sbjct: 816  VCPAGWY-GPSCQTRCSCANDGH---CHPATGHC-SCAPGWTGFSCQRACDTGHWG---- 866

Query: 1462 LPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPG 1521
                   C+ P   S+ + S   ++ GL       C  GY G  CE+  P      G+ G
Sbjct: 867  -----PDCSHPCNCSAGHGSCDAIS-GL-----CLCEAGYVGPRCEQQCP-----QGHFG 910

Query: 1522 GSC-QECECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558
              C Q C+C  +G+    CD V+G CTC  G  G  C+
Sbjct: 911  PGCEQRCQCQ-HGAA---CDHVSGACTCPAGWRGTFCE 944



 Score = 65.5 bits (158), Expect = 8e-10
 Identities = 57/197 (28%), Positives = 78/197 (39%), Gaps = 44/197 (22%)

Query: 1379 KCDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437
            +C CP G +G  CEA C  G + L  Q            C  CQ   H++ CDPET  C 
Sbjct: 757  QCRCPPGRTGEDCEADCPEGRWGLGCQE----------ICPACQ---HAARCDPETGACL 803

Query: 1438 NCQHHTAGDFCER-CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTA 1496
             C     G  C+  C  G+YG     P+   +C+C      +  +  C           +
Sbjct: 804  -CLPGFVGSRCQDVCPAGWYG-----PSCQTRCSCANDGHCHPATGHC-----------S 846

Query: 1497 CPRGYEGQYCERCAPGYTGSPGNPGGSCQE-CECDP-YGSLPVPCDPVTGFCTCRPGATG 1554
            C  G+ G  C+R         G+ G  C   C C   +GS    CD ++G C C  G  G
Sbjct: 847  CAPGWTGFSCQRAC-----DTGHWGPDCSHPCNCSAGHGS----CDAISGLCLCEAGYVG 897

Query: 1555 RKCD-GCKHWHAREGWE 1570
             +C+  C   H   G E
Sbjct: 898  PRCEQQCPQGHFGPGCE 914



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 56/204 (27%), Positives = 79/204 (38%), Gaps = 45/204 (22%)

Query: 1377 IEKCDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSI 1435
            ++ CDCP G++GL C E C P            T G        CQ  G    CD  T  
Sbjct: 537  LDGCDCPEGWTGLICNETCPPD-----------TFGKNCSFSCSCQNGG---TCDSVTGA 582

Query: 1436 CQNCQHHTAGDFCE-RCALGYYGIVKGLPNDC-QQCACPLISSSNNFSPSCVAEGLDDYR 1493
            C+ C    +G  CE  C  GYYG        C ++C C      +    +C+        
Sbjct: 583  CR-CPPGVSGTNCEDGCPKGYYG------KHCRKKCNCANRGRCHRLYGACL-------- 627

Query: 1494 CTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECEC-DPYGSLPVPCDPVTGFCTCRPGA 1552
               C  G  G++C    P +   P    G  +EC+C  P+      CD   G C+C+ G 
Sbjct: 628  ---CDPGLYGRFCHLTCPPWAFGP----GCSEECQCVQPHTQ---SCDKRDGSCSCKAGF 677

Query: 1553 TGRKCDG-CKHWHAREG-WECVFC 1574
             G +C   C+  +   G W+   C
Sbjct: 678  RGERCQAECELGYFGPGCWQACTC 701



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 65/234 (27%), Positives = 81/234 (34%), Gaps = 66/234 (28%)

Query: 1380 CDCPLGYSGLSCE-ACLPGFYRLRSQ--------------------PGGRTPGPTLGTCV 1418
            C CP G+ G  CE AC  GF+ L  +                    P GR  GP      
Sbjct: 932  CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRR-GPRCAETC 990

Query: 1419 PCQCNGHS----------SLCDPETSICQNCQHHTAGDFC-ERCALGYYGIVKGLPNDCQ 1467
            P    GH+          + CDP    C +C     G  C + C  G YG      ++C+
Sbjct: 991  PAHTYGHNCSQACACFNGASCDPVHGQC-HCAPGWMGPSCLQACPAGLYG------DNCR 1043

Query: 1468 Q-CACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCER-CAPGYTGSPGNPGGSCQ 1525
              C C    + +  S  C           ACP G+ G  CE+ C P    +     G C 
Sbjct: 1044 HSCLCQNGGTCDPVSGHC-----------ACPEGWAGLACEKECLPRDVRAGCRHSGGCL 1092

Query: 1526 ECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDECT 1579
                   G L   CDP TG C C  G TG KC          GW    C   C+
Sbjct: 1093 N------GGL---CDPHTGRCLCPAGWTGDKCQS----PCLRGWFGEACAQRCS 1133



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 72/252 (28%), Positives = 92/252 (36%), Gaps = 54/252 (21%)

Query: 293 ARACPLDPATNKSRCECEHNTC----GDSCDQCCPGFHQKPWRAGTF----LTKTECEAC 344
           A  CP+  A +    EC         G+ C Q CP         GTF     +   C   
Sbjct: 698 ACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECP--------VGTFGVNCSSSCSCGGA 749

Query: 345 NCHGKAEECYYDENVARRNLSLNIRGKYIGGG---VCINCTQNTAGINCET----CTDGF 397
            CHG   +C         +   +      G G   +C  C Q+ A  + ET    C  GF
Sbjct: 750 PCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPAC-QHAARCDPETGACLCLPGF 808

Query: 398 F--RPKGVSPN--YPRPCQP-CHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVS 452
              R + V P   Y   CQ  C C   G  +              A G C C  G+ G S
Sbjct: 809 VGSRCQDVCPAGWYGPSCQTRCSCANDGHCHP-------------ATGHCSCAPGWTGFS 855

Query: 453 CDR-CARGYTGYPDCK-ACNCSGLGSKNEDPCFGPCICKENVEGGDC-SRCKSGFFNLQE 509
           C R C  G+ G PDC   CNCS  G  + D   G C+C+    G  C  +C  G F    
Sbjct: 856 CQRACDTGHWG-PDCSHPCNCSA-GHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFG--- 910

Query: 510 DNWKGCDE-CFC 520
               GC++ C C
Sbjct: 911 ---PGCEQRCQC 919



 Score = 55.5 bits (132), Expect = 8e-07
 Identities = 65/244 (26%), Positives = 89/244 (36%), Gaps = 46/244 (18%)

Query: 307 CECEHNTCGDSCDQCCP--------GFHQKPWRAGTFLTKTECEAC-------NCHGKAE 351
           C+C     G  C++ CP         F       GT  + T    C       NC     
Sbjct: 540 CDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCP 599

Query: 352 ECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCE-TCTDGFFRPKGVSPNYPRP 410
           + YY ++  ++    N    +   G C+ C     G  C  TC    F P G S      
Sbjct: 600 KGYYGKHCRKKCNCANRGRCHRLYGACL-CDPGLYGRFCHLTCPPWAFGP-GCS------ 651

Query: 411 CQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD-RCARGYTGYPDC-KA 468
            + C C  +    + C K +         GSC CK GF G  C   C  GY G P C +A
Sbjct: 652 -EECQC--VQPHTQSCDKRD---------GSCSCKAGFRGERCQAECELGYFG-PGCWQA 698

Query: 469 CNCS-GLGSKNEDPCFGPC--ICKENVEGGDCSR-CKSGFFNLQEDNWKGCDECFCSGVS 524
           C C  G+     D   G C   C    +G DC + C  G F +   +   C    C GV+
Sbjct: 699 CTCPVGVAC---DSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVT 755

Query: 525 NRCQ 528
            +C+
Sbjct: 756 GQCR 759



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 63/235 (26%), Positives = 84/235 (35%), Gaps = 69/235 (29%)

Query: 295  ACPLDPATNK--SRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC-EACNCHGKAE 351
            +CP   A +     C C     G  C+Q CP         G+F    +C + C C G+  
Sbjct: 1133 SCPPGAACHHVTGACRCPPGFTGSGCEQACP--------PGSF--GEDCAQMCQCPGENP 1182

Query: 352  ECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCET-CTDGFFRPKGVSPNYPRP 410
             C+                     G C +C     G +C+  C  G + P          
Sbjct: 1183 ACHP------------------ATGTC-SCAAGYHGPSCQQRCPPGRYGPG--------- 1214

Query: 411  C-QPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD-RCARGYTGYPDC-K 467
            C Q C C   GS +              A G+C C TGF G  C+  C +G  G P+C  
Sbjct: 1215 CEQLCGCLNGGSCDA-------------ATGACRCPTGFLGTDCNLTCPQGRFG-PNCTH 1260

Query: 468  ACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFFNLQEDNWKGCDE-CFC 520
             C C G G+   DP  G C+C     G  C R C    F +      GC+  C C
Sbjct: 1261 VCGC-GQGAAC-DPVTGTCLCPPGRAGVRCERGCPQNRFGV------GCEHTCSC 1307



 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 70/268 (26%), Positives = 89/268 (33%), Gaps = 62/268 (23%)

Query: 286  MCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACN 345
            +C C G   AC  DP T    C C     G  C++ CP   Q  +  G   T +      
Sbjct: 1261 VCGC-GQGAAC--DPVTGT--CLCPPGRAGVRCERGCP---QNRFGVGCEHTCSCRNGGL 1312

Query: 346  CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCET------CTDGFFR 399
            CH     C        R+  L       G    + C+ +     CE       C  GF+ 
Sbjct: 1313 CHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNS-TCEPATGTCRCGPGFY- 1370

Query: 400  PKGVSPNYPRP-------------CQP-CHCDPIGSLNEVCVKDEKHARRGLAPGSCHCK 445
              G +  +P P             CQ    CDPI                    G C C 
Sbjct: 1371 --GQACEHPCPPGFHGAGCQGLCWCQHGAPCDPIS-------------------GRCLCP 1409

Query: 446  TGFGGVSCDR-CARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCS-RCKSG 503
             GF G  C+R C  G  G    + C+C G      DP  G C+C     G  C+  C+ G
Sbjct: 1410 AGFHGHFCERGCEPGSFGEGCHQRCDCDG--GAPCDPVTGLCLCPPGRSGATCNLDCRRG 1467

Query: 504  FF----NLQEDNWKGCDECFCSGVSNRC 527
             F     L  D   G D   C  VS +C
Sbjct: 1468 QFGPSCTLHCDCGGGAD---CDPVSGQC 1492



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 32/95 (33%), Positives = 39/95 (41%), Gaps = 16/95 (16%)

Query: 1497 CPRGYEGQYCERCAPGYTGSPGNPGGSCQ-ECECDPYGSLPVPCDPVTGFCTCRPGATGR 1555
            CP G+ G  C    P     P   G +C   C C   G+    CD VTG C C PG +G 
Sbjct: 542  CPEGWTGLICNETCP-----PDTFGKNCSFSCSCQNGGT----CDSVTGACRCPPGVSGT 592

Query: 1556 KC-DGCKHWHAREGWECVFCGDECTGLLLGDLARL 1589
             C DGC      +G+    C  +C     G   RL
Sbjct: 593  NCEDGCP-----KGYYGKHCRKKCNCANRGRCHRL 622



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 75/290 (25%), Positives = 95/290 (32%), Gaps = 76/290 (26%)

Query: 282  SVGGMCICYGH------ARACP---LDPATNKSRCECEHNTCGDSCDQ-----CCPGFHQ 327
            ++ G+C+C          + CP     P   + RC+C+H   G +CD       CP    
Sbjct: 884  AISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQ-RCQCQH---GAACDHVSGACTCPA--- 936

Query: 328  KPWRAGTFLTKTECE-ACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTA 386
              WR GTF     CE AC       +C                        C NC   TA
Sbjct: 937  -GWR-GTF-----CEHACPAGFFGLDC---------------------RSAC-NC---TA 964

Query: 387  GINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKT 446
            G  C+        P G     PR  + C     G            A      G CHC  
Sbjct: 965  GAACDAVNGSCLCPAG--RRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAP 1022

Query: 447  GFGGVSC-DRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGF 504
            G+ G SC   C  G  G     +C C   G+   DP  G C C E   G  C + C    
Sbjct: 1023 GWMGPSCLQACPAGLYGDNCRHSCLCQNGGTC--DPVSGHCACPEGWAGLACEKEC---- 1076

Query: 505  FNLQEDNWKGCDEC-------FCSGVSNRCQ-SSYWTYGKIQD--MSGWY 544
              L  D   GC           C   + RC   + WT  K Q   + GW+
Sbjct: 1077 --LPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWF 1124



 Score = 45.4 bits (106), Expect = 9e-04
 Identities = 74/323 (22%), Positives = 105/323 (32%), Gaps = 75/323 (23%)

Query: 277  SVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGF--------HQK 328
            S  + + G  C     +  CP      +    C  +T G +C Q C  F        H +
Sbjct: 958  SACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQ 1017

Query: 329  PWRAGTFLTKTECEAC-------------------NCHGKAEECYYDENVA-----RRNL 364
               A  ++  +  +AC                    C   +  C   E  A     +  L
Sbjct: 1018 CHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECL 1077

Query: 365  SLNIR------GKYIGGGVC------INCTQNTAGINCET-CTDGFFRPKGVSPNYPRPC 411
              ++R      G  + GG+C        C     G  C++ C  G+F           P 
Sbjct: 1078 PRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPG 1137

Query: 412  QPCH----------------CD---PIGSLNEVCVK----DEKHARRGLAPGSCHCKTGF 448
              CH                C+   P GS  E C +      ++     A G+C C  G+
Sbjct: 1138 AACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGY 1197

Query: 449  GGVSC-DRCARGYTGYPDC-KACNCSGLGSKNEDPCFGPCICKENVEGGDCS-RCKSGFF 505
             G SC  RC  G  G P C + C C   GS   D   G C C     G DC+  C  G F
Sbjct: 1198 HGPSCQQRCPPGRYG-PGCEQLCGCLNGGSC--DAATGACRCPTGFLGTDCNLTCPQGRF 1254

Query: 506  NLQEDNWKGCDE-CFCSGVSNRC 527
                 +  GC +   C  V+  C
Sbjct: 1255 GPNCTHVCGCGQGAACDPVTGTC 1277



 Score = 38.1 bits (87), Expect = 0.14
 Identities = 39/142 (27%), Positives = 50/142 (35%), Gaps = 34/142 (23%)

Query: 1373 PADLIE-KCDCPLGYSGLSCE-ACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCD 1430
            P D I  +C CP G+ G  CE  C PG +               G    C C+G  + CD
Sbjct: 1398 PCDPISGRCLCPAGFHGHFCERGCEPGSF-------------GEGCHQRCDCDG-GAPCD 1443

Query: 1431 PETSICQNCQHHTAGDFCE-RCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGL 1489
            P T +C  C    +G  C   C  G +G     P+    C C   +  +  S  C     
Sbjct: 1444 PVTGLCL-CPPGRSGATCNLDCRRGQFG-----PSCTLHCDCGGGADCDPVSGQC----- 1492

Query: 1490 DDYRCTACPRGYEGQYCERCAP 1511
                   C  GY G  C    P
Sbjct: 1493 ------HCVDGYMGPTCREGGP 1508


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score =  183 bits (464), Expect = 3e-45
 Identities = 157/539 (29%), Positives = 206/539 (38%), Gaps = 126/539 (23%)

Query: 715  GSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICE-PCQCFG-HAESCDDVTGE 772
            G  +     C+C PGY G  C+      R     + G  C  PC C   +  SC  VTG 
Sbjct: 324  GQCSPTTGACECEPGYKGPRCQE-----RLCPEGLHGPGCTLPCPCDADNTISCHPVTGA 378

Query: 773  CLNCKDHTGGPYCDKCLP-GFYGEPTKGTSEDCQ-PCACPLNIPSNNFSPTCHLDRS-LG 829
            C  C+    G +C++  P G+YG+        CQ PC C      ++ +  C      +G
Sbjct: 379  C-TCQPGWSGHHCNESCPVGYYGD-------GCQLPCTCQNGADCHSITGGCTCAPGFMG 430

Query: 830  LICD-GCPVGYTGPRCER-CAEGYFGQPSVPGGSCQ------------PC-------QCN 868
             +C   C  G  GP C   C+    G  S   GSC             PC        CN
Sbjct: 431  EVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCN 490

Query: 869  DNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL-CADGYFG-------DAVDAKNCQP--- 917
            ++   +   +C  + GSC  C PG  G  CEL C DG FG       D   A  C P   
Sbjct: 491  ESCTCANGAACSPIDGSCS-CTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTG 549

Query: 918  -----------------------------CRCNAGGSFSEVCHSQTGQCECRANVQGQRC 948
                                         C C  GGS    C  + G CEC    +G  C
Sbjct: 550  HCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGS----CSPEDGSCECAPGFRGPLC 605

Query: 949  DK-CKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDR-CAHGYFN 1005
             + C  G +G   A+ C  C        S  C   SG C C PG +G  C++ CA GYF 
Sbjct: 606  QRICPPGFYGHGCAQPCPLCV-----HSSRPCHHISGICECLPGFSGALCNQVCAGGYFG 660

Query: 1006 FQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSK-CAPNTWGHSITTGCKACNCST 1064
              +     C C++ G  C P  G C C P  IG+ CS+ C P  WG +      AC+C  
Sbjct: 661  --QDCAQLCSCANNGT-CSPIDGSCQCFPGWIGKDCSQACPPGFWGPACF---HACSCHN 714

Query: 1065 VGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRCNLCDCFLPGTDATTCDSETK 1123
              S    C+   G C+C P ++G  CT+ C    +      +C C               
Sbjct: 715  GAS----CSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQC-------------QN 757

Query: 1124 KCSCSDQTGQCTCKVNVEGIHCD-RCRPGKFGLDAKNPLGCSS-CYCFGTTTQCSEAKG 1180
              SC   +G+CTC+    G HC+ RC PG FG       GC   C C   +T C    G
Sbjct: 758  GASCDHISGKCTCRTGFTGQHCEQRCAPGTFG------YGCQQLCECMNNST-CDHVTG 809



 Score =  182 bits (462), Expect = 5e-45
 Identities = 155/484 (32%), Positives = 197/484 (40%), Gaps = 103/484 (21%)

Query: 724  CQCPPGYTGSSCES-CWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGG 782
            C C  G+ G  CE  C P      GT   G   PCQC  H  SCD   GECL    +T G
Sbjct: 161  CVCAAGFRGWRCEELCAP------GTHGKGCQLPCQC-RHGASCDPRAGECLCAPGYT-G 212

Query: 783  PYCDK-CLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTG 841
             YC++ C PG +G              C L  P  N   TCH    +   C  CP G+TG
Sbjct: 213  VYCEELCPPGSHG------------AHCELRCPCQN-GGTCH---HITGEC-ACPPGWTG 255

Query: 842  PRC-ERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYC-E 899
              C + C  G FGQ        Q C C+        G CD ++G C  C  G  G  C E
Sbjct: 256  AVCAQPCPPGTFGQ-----NCSQDCPCHHG------GQCDHVTGQC-HCTAGYMGDRCQE 303

Query: 900  LCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK--CKAGTFG 957
             C  G FG     +  Q C C+ GG     C   TG CEC    +G RC +  C  G  G
Sbjct: 304  ECPFGSFG----FQCSQHCDCHNGGQ----CSPTTGACECEPGYKGPRCQERLCPEGLHG 355

Query: 958  LQSARGC-VPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTAC 1014
                 GC +PC C++    +  C   +G C CQPG +G  C + C  GY+   +G    C
Sbjct: 356  ----PGCTLPCPCDA--DNTISCHPVTGACTCQPGWSGHHCNESCPVGYYG--DGCQLPC 407

Query: 1015 ECSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCN 1073
             C + G +C   TG C C P  +GE C+  CA  T+G + ++    C+C+  G+    C+
Sbjct: 408  TCQN-GADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSS---ICSCNNGGT----CS 459

Query: 1074 VNTGQCNCHPKFSGAKCT-ECSRGHWNYPRCNLCDC--------------FLPGTDATTC 1118
               G C C   + G  CT  C  G W       C C                PG    TC
Sbjct: 460  PVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTC 519

Query: 1119 D------------SETKKCS----CSDQTGQCTCKVNVEGIHCD-RCRPGKFGLDAKNPL 1161
            +            SE   CS    C   TG C C     GI CD  C PG++G +     
Sbjct: 520  ELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSC 579

Query: 1162 GCSS 1165
             C +
Sbjct: 580  SCEN 583



 Score =  175 bits (444), Expect = 6e-43
 Identities = 154/532 (28%), Positives = 202/532 (37%), Gaps = 138/532 (25%)

Query: 724  CQCPPGYTGSSC-ESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGG 782
            C CPPG+TG+ C + C P      GT      + C C  H   CD VTG+C     + G 
Sbjct: 247  CACPPGWTGAVCAQPCPP------GTFGQNCSQDCPCH-HGGQCDHVTGQCHCTAGYMGD 299

Query: 783  PYCDKCLPGFYG---------------EPTKGTSE--------DCQPCACPLNIPSNNFS 819
               ++C  G +G                PT G  E         CQ   CP  +     +
Sbjct: 300  RCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCT 359

Query: 820  PTCHLDRSLGLICDG------CPVGYTGPRC-ERCAEGYFGQPSVPGGSCQ-PCQCNDNL 871
              C  D    + C        C  G++G  C E C  GY+G        CQ PC C +  
Sbjct: 360  LPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGD------GCQLPCTCQNGA 413

Query: 872  DFSIPGSCDSLSGSCLICKPGTTGRYCEL-CADGYFGDAVDAKNCQP-CRCNAGGSFSEV 929
            D      C S++G C  C PG  G  C + CA G +G      NC   C CN GG+ S V
Sbjct: 414  D------CHSITGGCT-CAPGFMGEVCAVSCAAGTYGP-----NCSSICSCNNGGTCSPV 461

Query: 930  CHSQTGQCECRANVQGQRCD-KCKAGTFGLQSARGC------------------------ 964
                 G C C+   QG  C   C +GT+GL     C                        
Sbjct: 462  ----DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGD 517

Query: 965  ---VPCNCNSFG---SKSFDCEES-------GQCWCQPGVTGKKCDR-CAHGYFNFQEGG 1010
               +PC   +FG   S+  DC  +       G C C  G TG +CD  C  G +      
Sbjct: 518  TCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWG---PN 574

Query: 1011 CT-ACECSHLGNNCDPKTGRCICPPNTIGEKCSK-CAPNTWGHSITTGCKACNCSTVGSL 1068
            C+ +C C + G +C P+ G C C P   G  C + C P  +GH     C  C  S+    
Sbjct: 575  CSVSCSCEN-GGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSS---- 629

Query: 1069 DFQCNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSC 1127
               C+  +G C C P FSGA C + C+ G++      LC C   GT             C
Sbjct: 630  -RPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGT-------------C 675

Query: 1128 SDQTGQCTCKVNVEGIHCDR-CRPGKFG------LDAKNPLGCS----SCYC 1168
            S   G C C     G  C + C PG +G          N   CS    +C+C
Sbjct: 676  SPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHC 727



 Score =  158 bits (400), Expect = 7e-38
 Identities = 125/393 (31%), Positives = 167/393 (42%), Gaps = 71/393 (18%)

Query: 708  AVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCD 767
            A   P DGS       C C PG+ G +CE   P     +GT      E C C  HA+ CD
Sbjct: 499  AACSPIDGS-------CSCTPGWLGDTCELPCP-----DGTFGLNCSEHCDC-SHADGCD 545

Query: 768  DVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRS 827
             VTG C      TG      C PG +G P    S     C+C      +    +C     
Sbjct: 546  PVTGHCCCLAGWTGIRCDSTCPPGRWG-PNCSVS-----CSCENGGSCSPEDGSCE---- 595

Query: 828  LGLICDGCPVGYTGPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSC 886
                   C  G+ GP C+R C  G++G      G  QPC     L       C  +SG C
Sbjct: 596  -------CAPGFRGPLCQRICPPGFYGH-----GCAQPCP----LCVHSSRPCHHISGIC 639

Query: 887  LICKPGTTGRYC-ELCADGYFGDAVDAKNC-QPCRCNAGGSFSEVCHSQTGQCECRANVQ 944
              C PG +G  C ++CA GYFG     ++C Q C C   G+ S +     G C+C     
Sbjct: 640  E-CLPGFSGALCNQVCAGGYFG-----QDCAQLCSCANNGTCSPI----DGSCQCFPGWI 689

Query: 945  GQRCDK-CKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKC-DRCAHG 1002
            G+ C + C  G +G      C   +C++  S S    E G C C PG TG  C  RC   
Sbjct: 690  GKDCSQACPPGFWGPACFHAC---SCHNGASCS---AEDGACHCTPGWTGLFCTQRCPAA 743

Query: 1003 YFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACN 1061
            +F    G    C+C + G +CD  +G+C C     G+ C  +CAP T+G+     C+  N
Sbjct: 744  FFGKDCG--RVCQCQN-GASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMN 800

Query: 1062 CSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECS 1094
             ST       C+  TG C C P F G +C + +
Sbjct: 801  NST-------CDHVTGTCYCSPGFKGIRCDQAA 826



 Score =  158 bits (399), Expect = 9e-38
 Identities = 139/464 (29%), Positives = 179/464 (38%), Gaps = 107/464 (23%)

Query: 787  KCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSP-TCHLDRSLGL--ICDGCPVGYTGPR 843
            +C PG+Y      + + C P      +     SP TCH +   G      GC   + GP 
Sbjct: 87   QCCPGYYE-----SGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPH 141

Query: 844  CER------------------CAEGYFG-------QPSVPGGSCQ-PCQCNDNLDFSIPG 877
            C                    CA G+ G        P   G  CQ PCQC          
Sbjct: 142  CSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHG------A 195

Query: 878  SCDSLSGSCLICKPGTTGRYCE-LCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQ 936
            SCD  +G CL C PG TG YCE LC  G  G   + +    C C  GG+    CH  TG+
Sbjct: 196  SCDPRAGECL-CAPGYTGVYCEELCPPGSHGAHCELR----CPCQNGGT----CHHITGE 246

Query: 937  CECRANVQGQRCDK-CKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGK 994
            C C     G  C + C  GTFG   ++ C PC+          C+  +GQC C  G  G 
Sbjct: 247  CACPPGWTGAVCAQPCPPGTFGQNCSQDC-PCHHGG------QCDHVTGQCHCTAGYMGD 299

Query: 995  KC-DRCAHGYFNFQEGGCTA-CECSHLGNNCDPKTGRCICPPNTIGEKCSK--CAPNTWG 1050
            +C + C  G F FQ   C+  C+C H G  C P TG C C P   G +C +  C     G
Sbjct: 300  RCQEECPFGSFGFQ---CSQHCDC-HNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHG 355

Query: 1051 HSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRCNL-CDC 1108
               T  C     +T+      C+  TG C C P +SG  C E C  G++    C L C C
Sbjct: 356  PGCTLPCPCDADNTI-----SCHPVTGACTCQPGWSGHHCNESCPVGYYG-DGCQLPCTC 409

Query: 1109 ------------------FLPGTDATTCDSET--KKCS----------CSDQTGQCTCKV 1138
                              F+    A +C + T    CS          CS   G CTCK 
Sbjct: 410  QNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKE 469

Query: 1139 NVEGIHCD-RCRPGKFGLDAKNPLGCSS-CYCFGTTTQCSEAKG 1180
              +G+ C   C  G +GL+      C++   C      CS   G
Sbjct: 470  GWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPG 513



 Score = 75.9 bits (185), Expect = 6e-13
 Identities = 61/183 (33%), Positives = 78/183 (42%), Gaps = 45/183 (24%)

Query: 1380 CDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            C C  G+ G  C +AC PGF+           GP       C C+  +S C  E   C +
Sbjct: 682  CQCFPGWIGKDCSQACPPGFW-----------GPACFHA--CSCHNGAS-CSAEDGAC-H 726

Query: 1439 CQHHTAGDFC-ERCALGYYGIVKGLPNDCQQ-CACPLISSSNNFSPSCVAEGLDDYRCTA 1496
            C     G FC +RC   ++G       DC + C C   +S ++ S  C            
Sbjct: 727  CTPGWTGLFCTQRCPAAFFG------KDCGRVCQCQNGASCDHISGKCT----------- 769

Query: 1497 CPRGYEGQYCE-RCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGR 1555
            C  G+ GQ+CE RCAPG  G      G  Q CEC    +    CD VTG C C PG  G 
Sbjct: 770  CRTGFTGQHCEQRCAPGTFGY-----GCQQLCECMNNST----CDHVTGTCYCSPGFKGI 820

Query: 1556 KCD 1558
            +CD
Sbjct: 821  RCD 823



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 70/247 (28%), Positives = 88/247 (35%), Gaps = 84/247 (34%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL-CDPETSICQN 1438
            C+C  GY G  C+  L          G   PG TL    PC C+  +++ C P T  C  
Sbjct: 333  CECEPGYKGPRCQERL-------CPEGLHGPGCTL----PCPCDADNTISCHPVTGAC-T 380

Query: 1439 CQHHTAGDFC-ERCALGYYGIVKGLPNDCQQ------------CA-------CPLISSSN 1478
            CQ   +G  C E C +GYYG    LP  CQ             CA       C +  ++ 
Sbjct: 381  CQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAG 440

Query: 1479 NFSPSCVA--------------------EGLDDYRCTA-CPRGYEGQYCER--------- 1508
             + P+C +                    EG     CT  CP G  G  C           
Sbjct: 441  TYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAA 500

Query: 1509 ---------CAPGYTGSP-------GNPGGSCQE-CECDPYGSLPVPCDPVTGFCTCRPG 1551
                     C PG+ G         G  G +C E C+C         CDPVTG C C  G
Sbjct: 501  CSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADG----CDPVTGHCCCLAG 556

Query: 1552 ATGRKCD 1558
             TG +CD
Sbjct: 557  WTGIRCD 563



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 76/247 (30%), Positives = 95/247 (38%), Gaps = 84/247 (34%)

Query: 1380 CDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            C C  G+ G  CE  C PG +       G+      G  +PCQC  H + CDP    C  
Sbjct: 161  CVCAAGFRGWRCEELCAPGTH-------GK------GCQLPCQCR-HGASCDPRAGECL- 205

Query: 1439 CQHHTAGDFCER-CALGYYGIVKGLPNDCQ----------QCACPLI------------- 1474
            C     G +CE  C  G +G    L   CQ          +CACP               
Sbjct: 206  CAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPG 265

Query: 1475 SSSNNFSPSCVAE--GLDDY-----RCTA----------CPRGYEG----QYCE-----R 1508
            +   N S  C     G  D+      CTA          CP G  G    Q+C+     +
Sbjct: 266  TFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQ 325

Query: 1509 CAPGYTGS----PGNPGGSCQECECD-----PYGSLPVPCD--------PVTGFCTCRPG 1551
            C+P  TG+    PG  G  CQE  C      P  +LP PCD        PVTG CTC+PG
Sbjct: 326  CSPT-TGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG 384

Query: 1552 ATGRKCD 1558
             +G  C+
Sbjct: 385  WSGHHCN 391



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 65/234 (27%), Positives = 84/234 (35%), Gaps = 67/234 (28%)

Query: 1380 CDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            C C  G++G+ C++ C PG +           GP     V C C    S C PE   C+ 
Sbjct: 551  CCCLAGWTGIRCDSTCPPGRW-----------GPNCS--VSCSCENGGS-CSPEDGSCE- 595

Query: 1439 CQHHTAGDFCER-CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
            C     G  C+R C  G+YG      + C Q  CPL   S+   P     G+ +     C
Sbjct: 596  CAPGFRGPLCQRICPPGFYG------HGCAQ-PCPLCVHSSR--PCHHISGICE-----C 641

Query: 1498 PRGYEGQYCER-CAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556
              G+ G  C + CA GY G         Q C C   G+    C P+ G C C PG  G+ 
Sbjct: 642  LPGFSGALCNQVCAGGYFGQD-----CAQLCSCANNGT----CSPIDGSCQCFPGWIGKD 692

Query: 1557 CD----------GCKH----------------WHAREGWECVFCGDECTGLLLG 1584
            C            C H                 H   GW  +FC   C     G
Sbjct: 693  CSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFG 746



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 63/211 (29%), Positives = 83/211 (39%), Gaps = 56/211 (26%)

Query: 1380 CDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL-CDPETSICQ 1437
            C+C  G+ G  C+  C PGFY               G   PC    HSS  C   + IC+
Sbjct: 594  CECAPGFRGPLCQRICPPGFYGH-------------GCAQPCPLCVHSSRPCHHISGICE 640

Query: 1438 NCQHHTAGDFCER-CALGYYGIVKGLPNDCQQ-CACPLISSSNNFSPSCVA-EGLDDYRC 1494
             C    +G  C + CA GY+G       DC Q C+C    + +    SC    G     C
Sbjct: 641  -CLPGFSGALCNQVCAGGYFG------QDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDC 693

Query: 1495 T-ACPRGYEGQYCER------------------CAPGYTG-------SPGNPGGSC-QEC 1527
            + ACP G+ G  C                    C PG+TG            G  C + C
Sbjct: 694  SQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVC 753

Query: 1528 ECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558
            +C    S    CD ++G CTCR G TG+ C+
Sbjct: 754  QCQNGAS----CDHISGKCTCRTGFTGQHCE 780



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 56/218 (25%), Positives = 78/218 (35%), Gaps = 63/218 (28%)

Query: 286 MCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCP-GFHQKPWRAGTFLTKTECEAC 344
           +C C  +    P+D +     C+C     G  C Q CP GF    W    F       AC
Sbjct: 666 LCSCANNGTCSPIDGS-----CQCFPGWIGKDCSQACPPGF----WGPACF------HAC 710

Query: 345 NCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINC-ETCTDGFFRPKGV 403
           +CH  A  C  ++                  G C +CT    G+ C + C   FF     
Sbjct: 711 SCHNGAS-CSAED------------------GAC-HCTPGWTGLFCTQRCPAAFFG---- 746

Query: 404 SPNYPRPC-QPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD-RCARGYT 461
                + C + C C    S + +              G C C+TGF G  C+ RCA G  
Sbjct: 747 -----KDCGRVCQCQNGASCDHIS-------------GKCTCRTGFTGQHCEQRCAPGTF 788

Query: 462 GYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSR 499
           GY   + C C  + +   D   G C C    +G  C +
Sbjct: 789 GYGCQQLCEC--MNNSTCDHVTGTCYCSPGFKGIRCDQ 824



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 66/248 (26%), Positives = 87/248 (35%), Gaps = 67/248 (27%)

Query: 287 CICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNC 346
           C C   A   P+D +     C C     GD+C+  CP         GTF      E C+C
Sbjct: 493 CTCANGAACSPIDGS-----CSCTPGWLGDTCELPCPD--------GTFGLNCS-EHCDC 538

Query: 347 HGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCE-TCTDGFFRPK---G 402
              A+ C                   + G  C  C     GI C+ TC  G + P     
Sbjct: 539 -SHADGC-----------------DPVTGHCC--CLAGWTGIRCDSTCPPGRWGPNCSVS 578

Query: 403 VSPNYPRPCQP----CHCDP--IGSLNE-----------------VCVKDEKHARRGLAP 439
            S      C P    C C P   G L +                 +CV   +        
Sbjct: 579 CSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHH--IS 636

Query: 440 GSCHCKTGFGGVSCDR-CARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCS 498
           G C C  GF G  C++ CA GY G    + C+C+  G+ +  P  G C C     G DCS
Sbjct: 637 GICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCS--PIDGSCQCFPGWIGKDCS 694

Query: 499 R-CKSGFF 505
           + C  GF+
Sbjct: 695 QACPPGFW 702



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 72/262 (27%), Positives = 100/262 (38%), Gaps = 49/262 (18%)

Query: 287 CICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNC 346
           C C+ H   C  D  T +  C C     GD C + CP         G+F  +   + C+C
Sbjct: 275 CPCH-HGGQC--DHVTGQ--CHCTAGYMGDRCQEECP--------FGSFGFQCS-QHCDC 320

Query: 347 HGKAE--------ECYYDENVARRNLSLNIRGKYIGGGVCINC---TQNTAGINCETCTD 395
           H   +        EC       R    L   G + G G  + C     NT  I+C   T 
Sbjct: 321 HNGGQCSPTTGACECEPGYKGPRCQERLCPEGLH-GPGCTLPCPCDADNT--ISCHPVTG 377

Query: 396 GFFRPKGVSPNYPRPCQPCHCD---PIGSLNEVCVKD---EKHARRGLAPGSCHCKTGFG 449
                 G S +        HC+   P+G   + C      +  A      G C C  GF 
Sbjct: 378 ACTCQPGWSGH--------HCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFM 429

Query: 450 GVSCD-RCARGYTGYPDCKA-CNCSGLGSKNEDPCFGPCICKENVEGGDCS-RCKSGFFN 506
           G  C   CA G  G P+C + C+C+  G+ +  P  G C CKE  +G DC+  C SG + 
Sbjct: 430 GEVCAVSCAAGTYG-PNCSSICSCNNGGTCS--PVDGSCTCKEGWQGLDCTLPCPSGTWG 486

Query: 507 LQEDNWKGC-DECFCSGVSNRC 527
           L  +    C +   CS +   C
Sbjct: 487 LNCNESCTCANGAACSPIDGSC 508



 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 48/181 (26%), Positives = 62/181 (34%), Gaps = 43/181 (23%)

Query: 1380 CDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            C C  G+ GL C   C  G + L                  C C  + + C P    C +
Sbjct: 465  CTCKEGWQGLDCTLPCPSGTWGLNCNES-------------CTC-ANGAACSPIDGSC-S 509

Query: 1439 CQHHTAGDFCER-CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
            C     GD CE  C  G +G+     N  + C C      +  +  C            C
Sbjct: 510  CTPGWLGDTCELPCPDGTFGL-----NCSEHCDCSHADGCDPVTGHC-----------CC 553

Query: 1498 PRGYEGQYCERCAPGYTGSPGNPGGSCQ-ECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556
              G+ G  C+   P     PG  G +C   C C+  GS    C P  G C C PG  G  
Sbjct: 554  LAGWTGIRCDSTCP-----PGRWGPNCSVSCSCENGGS----CSPEDGSCECAPGFRGPL 604

Query: 1557 C 1557
            C
Sbjct: 605  C 605



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 59/243 (24%), Positives = 79/243 (32%), Gaps = 62/243 (25%)

Query: 287 CICYGHARACPLDPATNKSRCECEHNTCGDSCDQ-CCPGFHQKPWRAGTFLTKTECEACN 345
           C C   A   P+  A     C C     G  C++ C PG H K    G  L        +
Sbjct: 146 CQCQNGALCNPITGA-----CVCAAGFRGWRCEELCAPGTHGK----GCQLPCQCRHGAS 196

Query: 346 CHGKAEECY--------YDENVA---RRNLSLNIRGKYIGGGVCINCTQN-------TAG 387
           C  +A EC         Y E +           +R     GG C + T         T  
Sbjct: 197 CDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGA 256

Query: 388 INCETCTDGFFRPKGVSPNYPRPCQPCH----CDPIGSLNEVCVKDEKHARRGLAPGSCH 443
           +  + C  G F       N  + C PCH    CD +                    G CH
Sbjct: 257 VCAQPCPPGTF-----GQNCSQDC-PCHHGGQCDHV-------------------TGQCH 291

Query: 444 CKTGFGGVSC-DRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSR--C 500
           C  G+ G  C + C  G  G+   + C+C   G  +  P  G C C+   +G  C    C
Sbjct: 292 CTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCS--PTTGACECEPGYKGPRCQERLC 349

Query: 501 KSG 503
             G
Sbjct: 350 PEG 352



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 29/99 (29%), Positives = 40/99 (40%), Gaps = 12/99 (12%)

Query: 425 VCVKDEKHARRGLAPGSCHCKTGFGGVSCDR-CARGYTGYPDCKACNCSGLGSKNEDPCF 483
           +C ++  H R  ++P +CHC+ G+GG  C   C   + G      C C      N  P  
Sbjct: 102 LCTEECVHGRC-VSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCN--PIT 158

Query: 484 GPCICKENVEGGDCSR-CKSGFFNLQEDNWKGCD-ECFC 520
           G C+C     G  C   C  G       + KGC   C C
Sbjct: 159 GACVCAAGFRGWRCEELCAPG------THGKGCQLPCQC 191



 Score = 40.4 bits (93), Expect = 0.028
 Identities = 60/243 (24%), Positives = 82/243 (33%), Gaps = 61/243 (25%)

Query: 320 QCCPGFHQKPWRAGTFLTKTECEACNCHGKA---EECYYDENVARRNLSLNIRGKYIGGG 376
           QCCPG+++    +G F      E C  HG+    + C+ +      + S      +  G 
Sbjct: 87  QCCPGYYE----SGDFCIPLCTEEC-VHGRCVSPDTCHCEPGWGGPDCSSGCDSDH-WGP 140

Query: 377 VCINCTQNTAGINCE------TCTDGF--------FRPKGVSPNYPRPCQPCH---CDPI 419
            C N  Q   G  C        C  GF          P         PCQ  H   CDP 
Sbjct: 141 HCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDP- 199

Query: 420 GSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDR-CARGYTGYPDCKACNCSGLGSKN 478
                               G C C  G+ GV C+  C  G  G      C C   G+ +
Sbjct: 200 ------------------RAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCH 241

Query: 479 EDPCFGPCICKENVEGGDCSR-CKSGFF--NLQED----NWKGCD----ECFCSG--VSN 525
                G C C     G  C++ C  G F  N  +D    +   CD    +C C+   + +
Sbjct: 242 H--ITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGD 299

Query: 526 RCQ 528
           RCQ
Sbjct: 300 RCQ 302



 Score = 35.4 bits (80), Expect = 0.89
 Identities = 27/89 (30%), Positives = 34/89 (38%), Gaps = 23/89 (25%)

Query: 1493 RCTACPRGYE-GQYC-----ERCAPGYTGSP-------GNPGGSCQE-CECDPYG----- 1533
            R   CP  YE G +C     E C  G   SP       G  G  C   C+ D +G     
Sbjct: 85   RSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSN 144

Query: 1534 ----SLPVPCDPVTGFCTCRPGATGRKCD 1558
                     C+P+TG C C  G  G +C+
Sbjct: 145  RCQCQNGALCNPITGACVCAAGFRGWRCE 173



 Score = 32.0 bits (71), Expect = 9.8
 Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 16/76 (21%)

Query: 1379 KCDCPLGYSGLSCE-ACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437
            KC C  G++G  CE  C PG +    Q               C+C  +S+ CD  T  C 
Sbjct: 767  KCTCRTGFTGQHCEQRCAPGTFGYGCQQ-------------LCECMNNST-CDHVTGTCY 812

Query: 1438 NCQHHTAGDFCERCAL 1453
             C     G  C++ AL
Sbjct: 813  -CSPGFKGIRCDQAAL 827


>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score =  181 bits (460), Expect = 8e-45
 Identities = 148/498 (29%), Positives = 205/498 (41%), Gaps = 105/498 (21%)

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGP 783
            C C  G+ G  CE      R   GT      + CQC   A +CD VTGEC  C     G 
Sbjct: 167  CHCAAGFRGWRCED-----RCEQGTYGNDCHQRCQCQNGA-TCDHVTGEC-RCPPGYTGA 219

Query: 784  YC-DKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGP 842
            +C D C PG +G   +      Q C C      ++ +  C            CP G+ G 
Sbjct: 220  FCEDLCPPGKHGPQCE------QRCPCQNGGVCHHVTGEC-----------SCPSGWMGT 262

Query: 843  RC-ERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYC-EL 900
             C + C EG FG+        Q CQC++       G+CD+ +G C  C PG TG  C + 
Sbjct: 263  VCGQPCPEGRFGK-----NCSQECQCHNG------GTCDAATGQC-HCSPGYTGERCQDE 310

Query: 901  CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK--CKAGTFGL 958
            C  G +G        + C+C  GG     C+  +G C C A   G+RC+   C  G +G+
Sbjct: 311  CPVGTYG----VLCAETCQCVNGGK----CYHVSGACLCEAGFAGERCEARLCPEGLYGI 362

Query: 959  QSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTACEC 1016
            +  + C PC+  +    +  C   SG+C C+PG +G  C + C+ G++   E     C C
Sbjct: 363  KCDKRC-PCHLEN----THSCHPMSGECACKPGWSGLYCNETCSPGFYG--EACQQICSC 415

Query: 1017 SHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVN 1075
             + G +CD  TG+C C P   G  CS  C   T+G + ++ C   N       D  C+  
Sbjct: 416  QN-GADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKN-------DAVCSPV 467

Query: 1076 TGQCNCHPKFSGAKCT-ECSRGHW-----------NYPRCNLCD-------------CFL 1110
             G C C   + G  C+  C  G W           N   CN  D             C L
Sbjct: 468  DGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCEL 527

Query: 1111 PGTDATTCDSETKKCSCS------DQTGQCTCKVNVEGIHCDR-CRPGKFGLDAKNPLGC 1163
            P  D T   +  ++C CS        TG C C     G+HCD  C  G++G +   P   
Sbjct: 528  PCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLP--- 584

Query: 1164 SSCYCFGTTTQCSEAKGL 1181
              CYC      CS   G+
Sbjct: 585  --CYC-KNGASCSPDDGI 599



 Score =  178 bits (451), Expect = 8e-44
 Identities = 161/550 (29%), Positives = 211/550 (38%), Gaps = 131/550 (23%)

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICE---PCQCFGHAESCDDVTGECLNCKDHT 780
            C+CPPGYTG+ CE   P  +       G  CE   PCQ  G    C  VTGEC +C    
Sbjct: 210  CRCPPGYTGAFCEDLCPPGKH------GPQCEQRCPCQNGG---VCHHVTGEC-SCPSGW 259

Query: 781  GGPYCDK-CLPGFYGEPTKGTSEDCQ------------PCACPLNIPSNNFSPTCHLDRS 827
             G  C + C  G +G   K  S++CQ             C C            C +  +
Sbjct: 260  MGTVCGQPCPEGRFG---KNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVG-T 315

Query: 828  LGLICDG------------------CPVGYTGPRCER--CAEGYFGQPSVPGGSCQPCQC 867
             G++C                    C  G+ G RCE   C EG +G   +      PC  
Sbjct: 316  YGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYG---IKCDKRCPCHL 372

Query: 868  NDNLDFSIPGSCDSLSGSCLICKPGTTGRYC-ELCADGYFGDAVDAKNCQPCRCNAGGSF 926
             +        SC  +SG C  CKPG +G YC E C+ G++G+A      Q C C  G   
Sbjct: 373  ENT------HSCHPMSGEC-ACKPGWSGLYCNETCSPGFYGEACQ----QICSCQNGAD- 420

Query: 927  SEVCHSQTGQCECRANVQGQRCD-KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQC 985
               C S TG+C C    +G  C   C  GT+G+  +  C  C  ++  S        G C
Sbjct: 421  ---CDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRC-GCKNDAVCS-----PVDGSC 471

Query: 986  WCQPGVTGKKCD-RCAHGYFNFQEGGCT-ACECSHLGNNCDPKTGRCICPPNTIGEKCS- 1042
             C+ G  G  C  RC  G + F   GC   C+C + G  C+   G C C P   GEKC  
Sbjct: 472  TCKAGWHGVDCSIRCPSGTWGF---GCNLTCQCLN-GGACNTLDGTCTCAPGWRGEKCEL 527

Query: 1043 KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKC-TECSRGHWNYP 1101
             C   T+G +     + C+CS        C+  TG C C P +SG  C + C+ G W  P
Sbjct: 528  PCQDGTYGLNC---AERCDCSHADG----CHPTTGHCRCLPGWSGVHCDSVCAEGRWG-P 579

Query: 1102 RCNL----------------CDCFLPGTDATTCDSETK------KCS------------C 1127
             C+L                C+C  PG   TTC           +CS            C
Sbjct: 580  NCSLPCYCKNGASCSPDDGICEC-APGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPC 638

Query: 1128 SDQTGQCTCKVNVEGIHCDR-CRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWV 1186
               TG C C     G  C+  C  G+FG   KN  G  +C   GT      +      W+
Sbjct: 639  HHITGLCDCLPGFTGALCNEVCPSGRFG---KNCAGICTCTNNGTCNPIDRSCQCYPGWI 695

Query: 1187 TLKAEQTILP 1196
                 Q   P
Sbjct: 696  GSDCSQPCPP 705



 Score =  174 bits (442), Expect = 9e-43
 Identities = 155/525 (29%), Positives = 207/525 (39%), Gaps = 115/525 (21%)

Query: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEP-CQC-FGHAESCDDVTGECLNCKDHTG 781
            C C  G+ G  CE+     R     ++G  C+  C C   +  SC  ++GEC  CK    
Sbjct: 339  CLCEAGFAGERCEA-----RLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECA-CKPGWS 392

Query: 782  GPYCDK-CLPGFYGEPTKG-----TSEDCQP------CA-----------CPLNIPSNNF 818
            G YC++ C PGFYGE  +         DC        CA           CPL     N 
Sbjct: 393  GLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINC 452

Query: 819  SPTCHLDRSLGLIC---DG---CPVGYTGPRCE-RCAEGYFGQPSVPGGSCQPCQCNDNL 871
            S  C        +C   DG   C  G+ G  C  RC  G +G      G    CQC +  
Sbjct: 453  SSRCGCKNDA--VCSPVDGSCTCKAGWHGVDCSIRCPSGTWGF-----GCNLTCQCLNG- 504

Query: 872  DFSIPGSCDSLSGSCLICKPGTTGRYCEL-CADGYFGDAVDAKNC-QPCRCNAGGSFSEV 929
                 G+C++L G+C  C PG  G  CEL C DG +G      NC + C C    S ++ 
Sbjct: 505  -----GACNTLDGTCT-CAPGWRGEKCELPCQDGTYG-----LNCAERCDC----SHADG 549

Query: 930  CHSQTGQCECRANVQGQRCDK-CKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQ 988
            CH  TG C C     G  CD  C  G +G   +   +PC C +  S S D    G C C 
Sbjct: 550  CHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCS---LPCYCKNGASCSPD---DGICECA 603

Query: 989  PGVTGKKCDR-CAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPN 1047
            PG  G  C R C+ G++  +    T  +C H    C   TG C C P   G  C++  P+
Sbjct: 604  PGFRGTTCQRICSPGFYGHRCSQ-TCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPS 662

Query: 1048 TWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRC-NL 1105
              G         C C+  G+    CN     C C+P + G+ C++ C   HW  P C + 
Sbjct: 663  --GRFGKNCAGICTCTNNGT----CNPIDRSCQCYPGWIGSDCSQPCPPAHWG-PNCIHT 715

Query: 1106 CDCF--------------LPGTDATTCDSET------KKCS----------CSDQTGQCT 1135
            C+C                PG     C          K C+          C   +GQCT
Sbjct: 716  CNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCT 775

Query: 1136 CKVNVEGIHCD-RCRPGKFGLDAKNPLGC---SSCYCFGTTTQCS 1176
            C+    G HC+ +C  G +G   +    C   S+C     T  CS
Sbjct: 776  CRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCS 820



 Score =  139 bits (350), Expect = 4e-32
 Identities = 115/379 (30%), Positives = 156/379 (41%), Gaps = 72/379 (18%)

Query: 724  CQCPPGYTGSSCE-SCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGG 782
            C C PG+ G  CE  C       +GT      E C C  HA+ C   TG C  C     G
Sbjct: 514  CTCAPGWRGEKCELPCQ------DGTYGLNCAERCDC-SHADGCHPTTGHC-RCLPGWSG 565

Query: 783  PYCDK-CLPGFYGEPTKGTSEDCQ-PCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT 840
             +CD  C  G +G        +C  PC C           +C  D     IC+ C  G+ 
Sbjct: 566  VHCDSVCAEGRWGP-------NCSLPCYC-------KNGASCSPDDG---ICE-CAPGFR 607

Query: 841  GPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYC- 898
            G  C+R C+ G++G       +C  C  +      I G CD        C PG TG  C 
Sbjct: 608  GTTCQRICSPGFYGHRC--SQTCPQCVHSSGPCHHITGLCD--------CLPGFTGALCN 657

Query: 899  ELCADGYFGDAVDAKNCQP-CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK-CKAGTF 956
            E+C  G FG     KNC   C C   G+    C+     C+C     G  C + C    +
Sbjct: 658  EVCPSGRFG-----KNCAGICTCTNNGT----CNPIDRSCQCYPGWIGSDCSQPCPPAHW 708

Query: 957  GLQSARGCV-PCNCNSFGSKSFDCEESGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTAC 1014
            G      C+  CNC++    +F     G+C C PG TG  C  RC  G++   +     C
Sbjct: 709  G----PNCIHTCNCHN---GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYG--KDCALIC 759

Query: 1015 ECSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCN 1073
            +C + G +CD  +G+C C    +G  C  KC   T+G+     C   N ST       C+
Sbjct: 760  QCQN-GADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNST-------CD 811

Query: 1074 VNTGQCNCHPKFSGAKCTE 1092
              TG C C P + GA+C +
Sbjct: 812  HITGTCYCSPGWKGARCDQ 830



 Score =  130 bits (327), Expect = 2e-29
 Identities = 112/405 (27%), Positives = 155/405 (38%), Gaps = 75/405 (18%)

Query: 787  KCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSP-TCHLDRSLGLICDGCPVGYTGPRCE 845
            +C PGFY      + E C P      +     +P TC            C  G+ G  C 
Sbjct: 93   QCCPGFYE-----SGEMCVPHCADKCVHGRCIAPNTCQ-----------CEPGWGGTNCS 136

Query: 846  RCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCE-LCADG 904
               +G    P         CQC +         C+ ++G+C  C  G  G  CE  C  G
Sbjct: 137  SACDGDHWGPHCTSR----CQCKNG------ALCNPITGACH-CAAGFRGWRCEDRCEQG 185

Query: 905  YFGDAVDAKNC-QPCRCNAGGSFSEVCHSQTGQCECRANVQGQRC-DKCKAGTFGLQSAR 962
             +G+     +C Q C+C  G +    C   TG+C C     G  C D C  G  G Q  +
Sbjct: 186  TYGN-----DCHQRCQCQNGAT----CDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQ 236

Query: 963  GCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDR-CAHGYFNFQEGGCTACECSHLG 1020
             C PC           C   +G+C C  G  G  C + C  G F   +     C+C H G
Sbjct: 237  RC-PCQNGGV------CHHVTGECSCPSGWMGTVCGQPCPEGRFG--KNCSQECQC-HNG 286

Query: 1021 NNCDPKTGRCICPPNTIGEKC-SKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQC 1079
              CD  TG+C C P   GE+C  +C   T+G       + C C   G    +C   +G C
Sbjct: 287  GTCDAATGQCHCSPGYTGERCQDECPVGTYG---VLCAETCQCVNGG----KCYHVSGAC 339

Query: 1080 NCHPKFSGAKCTE--CSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCK 1137
             C   F+G +C    C  G +       C C L  T            SC   +G+C CK
Sbjct: 340  LCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTH-----------SCHPMSGECACK 388

Query: 1138 VNVEGIHC-DRCRPGKFGLDAKNPLGC-SSCYCFGTTTQCSEAKG 1180
                G++C + C PG +G   +    C +   C   T +C+ A G
Sbjct: 389  PGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPG 433



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 70/242 (28%), Positives = 92/242 (38%), Gaps = 74/242 (30%)

Query: 1379 KCDCPLGYSGLSCE-ACLPGFY------RLRSQPGG---------RTPGPTLGTCV---- 1418
            +C CP GY+G  CE  C PG +      R   Q GG           P   +GT      
Sbjct: 209  ECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC 268

Query: 1419 -----------PCQCNGHSSLCDPETSICQNCQHHTAGDFCE-RCALGYYGIVKGLPNDC 1466
                        CQC+ +   CD  T  C +C     G+ C+  C +G YG++       
Sbjct: 269  PEGRFGKNCSQECQCH-NGGTCDAATGQC-HCSPGYTGERCQDECPVGTYGVLCA----- 321

Query: 1467 QQCACPLISSSNNFSPSCVAE-GLDDYRCTA--CPRGYEGQYCER--------------- 1508
            + C C       + S +C+ E G    RC A  CP G  G  C++               
Sbjct: 322  ETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPM 381

Query: 1509 -----CAPGYTG-------SPGNPGGSCQE-CECDPYGSLPVPCDPVTGFCTCRPGATGR 1555
                 C PG++G       SPG  G +CQ+ C C         CD VTG CTC PG  G 
Sbjct: 382  SGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD----CDSVTGKCTCAPGFKGI 437

Query: 1556 KC 1557
             C
Sbjct: 438  DC 439



 Score = 72.0 bits (175), Expect = 9e-12
 Identities = 69/241 (28%), Positives = 89/241 (36%), Gaps = 82/241 (34%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNC 1439
            C C  G+ G +C +   G +           GP   +   CQC  + +LC+P T  C +C
Sbjct: 124  CQCEPGWGGTNCSSACDGDHW----------GPHCTS--RCQCK-NGALCNPITGAC-HC 169

Query: 1440 QHHTAGDFCE-RCALGYYGIVKGLPNDC-QQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
                 G  CE RC  G YG      NDC Q+C C   ++ ++ +  C            C
Sbjct: 170  AAGFRGWRCEDRCEQGTYG------NDCHQRCQCQNGATCDHVTGEC-----------RC 212

Query: 1498 PRGYEGQYCER-CAPGYTGS------PGNPGGSC-------------------------- 1524
            P GY G +CE  C PG  G       P   GG C                          
Sbjct: 213  PPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGR 272

Query: 1525 ------QECECDPYGSLPVPCDPVTGFCTCRPGATGRKC-DGCKHWHAREGWECVFCGDE 1577
                  QEC+C   G+    CD  TG C C PG TG +C D C       G   V C + 
Sbjct: 273  FGKNCSQECQCHNGGT----CDAATGQCHCSPGYTGERCQDECP-----VGTYGVLCAET 323

Query: 1578 C 1578
            C
Sbjct: 324  C 324



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 63/228 (27%), Positives = 74/228 (32%), Gaps = 67/228 (29%)

Query: 1379 KCDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437
            +C C  G+SGL C E C PGFY    Q               C C   +  CD  T  C 
Sbjct: 384  ECACKPGWSGLYCNETCSPGFYGEACQQ-------------ICSCQNGAD-CDSVTGKCT 429

Query: 1438 NCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
                    D    C LG YGI     N   +C C   +  +    SC            C
Sbjct: 430  CAPGFKGIDCSTPCPLGTYGI-----NCSSRCGCKNDAVCSPVDGSCT-----------C 473

Query: 1498 PRGYEGQYCE-RCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556
              G+ G  C  RC  G  G      G    C+C   G+    C+ + G CTC PG  G K
Sbjct: 474  KAGWHGVDCSIRCPSGTWGF-----GCNLTCQCLNGGA----CNTLDGTCTCAPGWRGEK 524

Query: 1557 C----------------------DGCK----HWHAREGWECVFCGDEC 1578
            C                      DGC     H     GW  V C   C
Sbjct: 525  CELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVC 572



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 61/213 (28%), Positives = 80/213 (37%), Gaps = 62/213 (29%)

Query: 1380 CDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVP----CQC------NGHSSL 1428
            CDC  G++G  C E C  G  R      G       GTC P    CQC      +  S  
Sbjct: 645  CDCLPGFTGALCNEVCPSG--RFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQP 702

Query: 1429 CDP--------ETSICQN------------CQHHTAGDFC-ERCALGYYGIVKGLPNDCQ 1467
            C P         T  C N            C     G +C +RC LG+YG       DC 
Sbjct: 703  CPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYG------KDCA 756

Query: 1468 Q-CACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQE 1526
              C C   +  ++ S  C            C  G+ G++CE+  P      G  G  C++
Sbjct: 757  LICQCQNGADCDHISGQCT-----------CRTGFMGRHCEQKCPS-----GTYGYGCRQ 800

Query: 1527 -CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558
             C+C    +    CD +TG C C PG  G +CD
Sbjct: 801  ICDCLNNST----CDHITGTCYCSPGWKGARCD 829



 Score = 62.4 bits (150), Expect = 7e-09
 Identities = 56/219 (25%), Positives = 74/219 (33%), Gaps = 63/219 (28%)

Query: 285 GMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC-EA 343
           G+C C  +    P+D +     C+C     G  C Q CP  H  P           C   
Sbjct: 671 GICTCTNNGTCNPIDRS-----CQCYPGWIGSDCSQPCPPAHWGP----------NCIHT 715

Query: 344 CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINC-ETCTDGFFRPKG 402
           CNCH  A    YD                   G C  CT    G+ C + C  GF     
Sbjct: 716 CNCHNGAFCSAYD-------------------GEC-KCTPGWTGLYCTQRCPLGF----- 750

Query: 403 VSPNYPRPCQ-PCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD-RCARGY 460
               Y + C   C C      + +              G C C+TGF G  C+ +C  G 
Sbjct: 751 ----YGKDCALICQCQNGADCDHI-------------SGQCTCRTGFMGRHCEQKCPSGT 793

Query: 461 TGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSR 499
            GY   + C+C  L +   D   G C C    +G  C +
Sbjct: 794 YGYGCRQICDC--LNNSTCDHITGTCYCSPGWKGARCDQ 830



 Score = 62.0 bits (149), Expect = 9e-09
 Identities = 55/182 (30%), Positives = 73/182 (40%), Gaps = 41/182 (22%)

Query: 1380 CDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
            C C  G+ G  CE  C  G Y L                  C C+ H+  C P T  C+ 
Sbjct: 514  CTCAPGWRGEKCELPCQDGTYGLNCAER-------------CDCS-HADGCHPTTGHCR- 558

Query: 1439 CQHHTAGDFCER-CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
            C    +G  C+  CA G +G     PN    C C    +  + SP       DD  C   
Sbjct: 559  CLPGWSGVHCDSVCAEGRWG-----PNCSLPCYC---KNGASCSP-------DDGICECA 603

Query: 1498 PRGYEGQYCER-CAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556
            P G+ G  C+R C+PG+ G   +   +C +C          PC  +TG C C PG TG  
Sbjct: 604  P-GFRGTTCQRICSPGFYGHRCSQ--TCPQCVHSSG-----PCHHITGLCDCLPGFTGAL 655

Query: 1557 CD 1558
            C+
Sbjct: 656  CN 657



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 69/270 (25%), Positives = 94/270 (34%), Gaps = 53/270 (19%)

Query: 289 CYGHARACPLDPATNKSRCE---CEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACN 345
           CY  + AC  +      RCE   C     G  CD+ CP            L  T     +
Sbjct: 332 CYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCP----------CHLENTH----S 377

Query: 346 CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCT-QNTAGINCE------TCTDGFF 398
           CH  + EC      +    +      + G      C+ QN  G +C+      TC  GF 
Sbjct: 378 CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQN--GADCDSVTGKCTCAPGF- 434

Query: 399 RPKGVSPNYPRPCQPCHCDPIGSLNEVCVKD---EKHARRGLAPGSCHCKTGFGGVSCD- 454
             KG+  +      PC   P+G+    C      +  A      GSC CK G+ GV C  
Sbjct: 435 --KGIDCS-----TPC---PLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSI 484

Query: 455 RCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCS-RCKSGFFNLQEDNWK 513
           RC  G  G+     C C   G+ N     G C C     G  C   C+ G + L      
Sbjct: 485 RCPSGTWGFGCNLTCQCLNGGACN--TLDGTCTCAPGWRGEKCELPCQDGTYGL-----N 537

Query: 514 GCDECFCSGVSNRCQSSYWTYGKIQDMSGW 543
             + C CS         + T G  + + GW
Sbjct: 538 CAERCDCS----HADGCHPTTGHCRCLPGW 563



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 70/295 (23%), Positives = 91/295 (30%), Gaps = 62/295 (21%)

Query: 284 GGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKT---- 339
           G MC+ +  A  C        + C+CE    G +C   C G H  P        K     
Sbjct: 102 GEMCVPHC-ADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALC 160

Query: 340 -------ECEA----CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGI 388
                   C A      C  + E+  Y  +  +R    N        G C  C     G 
Sbjct: 161 NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGEC-RCPPGYTGA 219

Query: 389 NCE-TCTDGFFRPKGVSPNYPRPCQ----------PCHCDPIGSLNEVCVKDEKHARRG- 436
            CE  C  G     G       PCQ           C C P G +  VC +     R G 
Sbjct: 220 FCEDLCPPG---KHGPQCEQRCPCQNGGVCHHVTGECSC-PSGWMGTVCGQPCPEGRFGK 275

Query: 437 ---------------LAPGSCHCKTGFGGVSC-DRCARGYTGYPDCKACNCSGLGSKNED 480
                           A G CHC  G+ G  C D C  G  G    + C C      N  
Sbjct: 276 NCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQC-----VNGG 330

Query: 481 PCF---GPCICKENVEGGDCSR--CKSGFFNLQEDNWKGC---DECFCSGVSNRC 527
            C+   G C+C+    G  C    C  G + ++ D    C   +   C  +S  C
Sbjct: 331 KCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGEC 385



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 73/301 (24%), Positives = 100/301 (33%), Gaps = 60/301 (19%)

Query: 281 ISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTE 340
           I+    C C   A   P+D +     C C+    G  C   CP      W  G  LT  +
Sbjct: 450 INCSSRCGCKNDAVCSPVDGS-----CTCKAGWHGVDCSIRCPS---GTWGFGCNLT-CQ 500

Query: 341 C---EACN----------------CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381
           C    ACN                C    ++  Y  N A R    +  G +   G C  C
Sbjct: 501 CLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHC-RC 559

Query: 382 TQNTAGINCET-CTDGFFRPKGVSPNYPR---PCQP----CHCDP------------IGS 421
               +G++C++ C +G + P    P Y +    C P    C C P             G 
Sbjct: 560 LPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGF 619

Query: 422 LNEVCVKDEKHARRGLAP-----GSCHCKTGFGGVSCDR-CARGYTGYPDCKACNCSGLG 475
               C +          P     G C C  GF G  C+  C  G  G      C C+  G
Sbjct: 620 YGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNG 679

Query: 476 SKNEDPCFGPCICKENVEGGDCSR-CKSGFFNLQEDNWKGC-DECFCSGVSNRCQ-SSYW 532
           + N  P    C C     G DCS+ C    +     +   C +  FCS     C+ +  W
Sbjct: 680 TCN--PIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW 737

Query: 533 T 533
           T
Sbjct: 738 T 738



 Score = 48.9 bits (115), Expect = 8e-05
 Identities = 65/232 (28%), Positives = 78/232 (33%), Gaps = 57/232 (24%)

Query: 307 CECEHNTCGDSCDQ------CCPGFH----QKPWRAGTFLTKTECEACNCHGKAEECYYD 356
           C C++   G  CD       C PGF       P   GT+         NC  +   C  D
Sbjct: 413 CSCQN---GADCDSVTGKCTCAPGFKGIDCSTPCPLGTY-------GINCSSRCG-CKND 461

Query: 357 ENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCE------------------TCTDGFF 398
              +  + S   +  + G    I C   T G  C                   TC  G+ 
Sbjct: 462 AVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWR 521

Query: 399 RPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAP--GSCHCKTGFGGVSCDR- 455
             K        PCQ    D    LN     D  HA  G  P  G C C  G+ GV CD  
Sbjct: 522 GEK-----CELPCQ----DGTYGLNCAERCDCSHAD-GCHPTTGHCRCLPGWSGVHCDSV 571

Query: 456 CARGYTGYPDCK-ACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFF 505
           CA G  G P+C   C C    S + D   G C C     G  C R C  GF+
Sbjct: 572 CAEGRWG-PNCSLPCYCKNGASCSPDD--GICECAPGFRGTTCQRICSPGFY 620



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 47/182 (25%), Positives = 59/182 (32%), Gaps = 57/182 (31%)

Query: 320 QCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCI 379
           QCCPGF++              E C  H  A++C              + G+ I    C 
Sbjct: 93  QCCPGFYESG------------EMCVPH-CADKC--------------VHGRCIAPNTC- 124

Query: 380 NCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQ---PCHCDPIGSLNEVCVKDEKHARRG 436
            C     G NC +  DG        P+    CQ      C+PI                 
Sbjct: 125 QCEPGWGGTNCSSACDG----DHWGPHCTSRCQCKNGALCNPI----------------- 163

Query: 437 LAPGSCHCKTGFGGVSC-DRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGG 495
              G+CHC  GF G  C DRC +G  G    + C C        D   G C C     G 
Sbjct: 164 --TGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQ--NGATCDHVTGECRCPPGYTGA 219

Query: 496 DC 497
            C
Sbjct: 220 FC 221



 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 17/120 (14%)

Query: 416 CDPIGSLNEVCVK---DEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKA-CNC 471
           C       E+CV    D+    R +AP +C C+ G+GG +C     G    P C + C C
Sbjct: 95  CPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQC 154

Query: 472 SGLGSKNEDPCFGPCICKENVEGGDC-SRCKSGFF------NLQEDNWKGCD----ECFC 520
                 N  P  G C C     G  C  RC+ G +        Q  N   CD    EC C
Sbjct: 155 KNGALCN--PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRC 212



 Score = 36.2 bits (82), Expect = 0.52
 Identities = 38/157 (24%), Positives = 61/157 (38%), Gaps = 35/157 (22%)

Query: 1379 KCDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437
            +C C  G++GL C + C  GFY       G+         + CQC   +  CD  +  C 
Sbjct: 730  ECKCTPGWTGLYCTQRCPLGFY-------GK------DCALICQCQNGAD-CDHISGQC- 774

Query: 1438 NCQHHTAGDFCE-RCALGYYGIVKGLPNDCQQ-CACPLISSSNNFSPSCVAEGLDDYRCT 1495
             C+    G  CE +C  G YG        C+Q C C   S+ ++ + +C           
Sbjct: 775  TCRTGFMGRHCEQKCPSGTYGY------GCRQICDCLNNSTCDHITGTCY---------- 818

Query: 1496 ACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPY 1532
             C  G++G  C++      G+  +   +      D Y
Sbjct: 819  -CSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSY 854


>gi|164414431 netrin G1 isoform 1 [Homo sapiens]
          Length = 539

 Score =  169 bits (429), Expect = 3e-41
 Identities = 134/482 (27%), Positives = 207/482 (42%), Gaps = 88/482 (18%)

Query: 57  TCGEKGPEMYCKLVEHVPGQPVR-NPQCRICNQNSSNPNQRHPITNAIDGK----NTWWQ 111
           TCG+  PE +C +     G P   N +C     ++S P   HP     D +    +T+WQ
Sbjct: 71  TCGDP-PETFCAM-----GNPYMCNNEC-----DASTPELAHPPELMFDFEGRHPSTFWQ 119

Query: 112 SPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLD-DVEYKPWQYHA 170
           S + K   +   V ITL   +  ++   IV    S RP   ILE+SLD    ++P+QY+A
Sbjct: 120 SATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYA 179

Query: 171 VTDTECLTLYNIYPRTGPP-SYAKDDEVICTSFYSKIHPLENGEIHISLING-------- 221
              T+CL  +++ P++    S     E+ICT  YS  +   +  IH  + +         
Sbjct: 180 ---TDCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPR 236

Query: 222 -RPSAD-----DPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYY 275
            R  A      D + +L +F +   +R+R   +R    ++          +D +   RY+
Sbjct: 237 LRNMASLYGQLDTTKKLRDFFTVTDLRIRL--LRPAVGEIF---------VDELHLARYF 285

Query: 276 YSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTF 335
           Y++ DI V G C C  HA  C  D   +K  CECEHNT G  C +C   +  +PW  G++
Sbjct: 286 YAISDIKVRGRCKCNLHATVCVYD--NSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSY 343

Query: 336 L-----TKTECEA-------CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQ 383
           L     T   C         C C G +  C Y +               +   +C++C  
Sbjct: 344 LPIPKGTANTCIPSISSIGNCECFGHSNRCSYID--------------LLNTVICVSCKH 389

Query: 384 NTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCH 443
           NT G +CE C  G+FR      +    C  C+C+P+GS+++ C             G C 
Sbjct: 390 NTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRC----------NGSGFCE 439

Query: 444 CKTGFGGVSCDRCARGYTGYPDCK--ACNCSGLGSKNEDPCFG--PCICKENVEGGDCSR 499
           CKTG  G  CD C  G + +  C+   C+   L  +N   C     C+C     G  C +
Sbjct: 440 CKTGTTGPKCDECLPGNSWHYGCQPNVCDNELLHCQNGGTCHNNVRCLCPAAYTGILCEK 499

Query: 500 CK 501
            +
Sbjct: 500 LR 501



 Score = 87.8 bits (216), Expect = 2e-16
 Identities = 65/215 (30%), Positives = 92/215 (42%), Gaps = 35/215 (16%)

Query: 807 CACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQ 866
           C C L+      +  C  D S  L C+ C    TGP C +C + Y G+P  PG      +
Sbjct: 297 CKCNLH------ATVCVYDNSK-LTCE-CEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPK 348

Query: 867 CNDNL---DFSIPGSCDSLSGS-------------CLICKPGTTGRYCELCADGYFGDA- 909
              N      S  G+C+    S             C+ CK  T G++CELC  GYF +A 
Sbjct: 349 GTANTCIPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNAS 408

Query: 910 --VDAKN-CQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVP 966
             +D +N C  C CN  GS  + C+  +G CEC+    G +CD+C  G        GC P
Sbjct: 409 AQLDDENVCIECYCNPLGSIHDRCNG-SGFCECKTGTTGPKCDECLPGN---SWHYGCQP 464

Query: 967 CNCNS---FGSKSFDCEESGQCWCQPGVTGKKCDR 998
             C++          C  + +C C    TG  C++
Sbjct: 465 NVCDNELLHCQNGGTCHNNVRCLCPAAYTGILCEK 499



 Score = 87.8 bits (216), Expect = 2e-16
 Identities = 57/168 (33%), Positives = 77/168 (45%), Gaps = 28/168 (16%)

Query: 1420 CQCNGHSSLCDPETS-ICQNCQHHTAGDFCERCALGYYG----------IVKGLPNDCQQ 1468
            C+CN H+++C  + S +   C+H+T G  C +C   Y G          I KG  N C  
Sbjct: 297  CKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTC-- 354

Query: 1469 CACPLISSSNN-----FSPSC-VAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPG---N 1519
               P ISS  N      S  C   + L+   C +C     GQ+CE C  GY  +     +
Sbjct: 355  --IPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLD 412

Query: 1520 PGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGC---KHWH 1564
                C EC C+P GS+   C+  +GFC C+ G TG KCD C     WH
Sbjct: 413  DENVCIECYCNPLGSIHDRCNG-SGFCECKTGTTGPKCDECLPGNSWH 459



 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 51/167 (30%), Positives = 69/167 (41%), Gaps = 29/167 (17%)

Query: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGP--TLGTCVP-------CQCNGHSSLCD 1430
            C+C    +G  C  C   +      PG   P P  T  TC+P       C+C GHS+ C 
Sbjct: 315  CECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCS 374

Query: 1431 P----ETSICQNCQHHTAGDFCERCALGYYGIVKGLPND---CQQCACPLISSSNNFSPS 1483
                  T IC +C+H+T G  CE C LGY+       +D   C +C C  + S ++    
Sbjct: 375  YIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHD---R 431

Query: 1484 CVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECD 1530
            C   G  +     C  G  G  C+ C PG +   G     CQ   CD
Sbjct: 432  CNGSGFCE-----CKTGTTGPKCDECLPGNSWHYG-----CQPNVCD 468



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 62/225 (27%), Positives = 85/225 (37%), Gaps = 38/225 (16%)

Query: 899  ELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGL 958
            EL    YF    D K    C+CN   +     +S+   CEC  N  G  C KCK    G 
Sbjct: 278  ELHLARYFYAISDIKVRGRCKCNLHATVCVYDNSKL-TCECEHNTTGPDCGKCKKNYQGR 336

Query: 959  Q------------SARGCVPC-----NCNSFGSKS----FDCEESGQCW-CQPGVTGKKC 996
                         +A  C+P      NC  FG  +     D   +  C  C+    G+ C
Sbjct: 337  PWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHC 396

Query: 997  DRCAHGYFNF------QEGGCTACECSHLGNNCDPKTGR--CICPPNTIGEKCSKCAP-N 1047
            + C  GYF         E  C  C C+ LG+  D   G   C C   T G KC +C P N
Sbjct: 397  ELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCDECLPGN 456

Query: 1048 TWGHSITTGCK--ACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKC 1090
            +W +    GC+   C+   +   +     N  +C C   ++G  C
Sbjct: 457  SWHY----GCQPNVCDNELLHCQNGGTCHNNVRCLCPAAYTGILC 497



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 54/218 (24%), Positives = 78/218 (35%), Gaps = 48/218 (22%)

Query: 967  CNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGY----------FNFQEGGCTAC-- 1014
            C CN   +          C C+   TG  C +C   Y              +G    C  
Sbjct: 297  CKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIP 356

Query: 1015 ECSHLGN-NCDPKTGRCI------------CPPNTIGEKCSKCAPNTWGHSIT-----TG 1056
              S +GN  C   + RC             C  NT G+ C  C    + ++         
Sbjct: 357  SISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENV 416

Query: 1057 CKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGH-WNYPRCNLCDCFLPGTDA 1115
            C  C C+ +GS+  +CN  +G C C    +G KC EC  G+ W+Y           G   
Sbjct: 417  CIECYCNPLGSIHDRCN-GSGFCECKTGTTGPKCDECLPGNSWHY-----------GCQP 464

Query: 1116 TTCDSETKKC----SCSDQTGQCTCKVNVEGIHCDRCR 1149
              CD+E   C    +C +   +C C     GI C++ R
Sbjct: 465  NVCDNELLHCQNGGTCHNNV-RCLCPAAYTGILCEKLR 501



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 65/243 (26%), Positives = 90/243 (37%), Gaps = 73/243 (30%)

Query: 724 CQCPPGYTGSSCESCWPRHRR-----------VNGTIFGGICEP-------CQCFGHAES 765
           C+C    TG  C  C   ++              GT     C P       C+CFGH+  
Sbjct: 315 CECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGT--ANTCIPSISSIGNCECFGHSNR 372

Query: 766 CDDV----TGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED--CQPCACPLNIPSNNFS 819
           C  +    T  C++CK +T G +C+ C  G++   +    ++  C  C C       N  
Sbjct: 373 CSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYC-------NPL 425

Query: 820 PTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGS----CQPCQCNDNLDFSI 875
            + H DR  G     C  G TGP+C+ C         +PG S    CQP  C++ L    
Sbjct: 426 GSIH-DRCNGSGFCECKTGTTGPKCDEC---------LPGNSWHYGCQPNVCDNEL---- 471

Query: 876 PGSCDSLSGSCLICKPGTT--GRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQ 933
                      L C+ G T       LC   Y G       C+  RC   GS    C S 
Sbjct: 472 -----------LHCQNGGTCHNNVRCLCPAAYTGIL-----CEKLRCEEAGS----CGSD 511

Query: 934 TGQ 936
           +GQ
Sbjct: 512 SGQ 514



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 49/151 (32%), Positives = 57/151 (37%), Gaps = 31/151 (20%)

Query: 726 CPPGYTGSSCESCWPRHRRVNGTIFG--GICEPCQC--FGHAESCDDVTGECLNCKDHTG 781
           C     G  CE C   + R          +C  C C   G      + +G C  CK  T 
Sbjct: 387 CKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFC-ECKTGTT 445

Query: 782 GPYCDKCLPG---FYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLD-RSLGLICDGCPV 837
           GP CD+CLPG    YG         CQP  C   +       TCH + R L      CP 
Sbjct: 446 GPKCDECLPGNSWHYG---------CQPNVCDNELLHCQNGGTCHNNVRCL------CPA 490

Query: 838 GYTGPRCE--RCAE-----GYFGQPSVPGGS 861
            YTG  CE  RC E        GQ + P GS
Sbjct: 491 AYTGILCEKLRCEEAGSCGSDSGQGAPPHGS 521



 Score = 45.8 bits (107), Expect = 7e-04
 Identities = 38/160 (23%), Positives = 54/160 (33%), Gaps = 23/160 (14%)

Query: 1014 CECSHLGNNC--DPKTGRCICPPNTIGEKCSKCAPNTWGHSITTG---------CKACNC 1062
            C+C+     C  D     C C  NT G  C KC  N  G   + G            C  
Sbjct: 297  CKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIP 356

Query: 1063 STVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSET 1122
            S     + +C  ++ +C+     +   C  C   +     C LC        +   D E 
Sbjct: 357  SISSIGNCECFGHSNRCSYIDLLNTVICVSCKH-NTRGQHCELCRLGYFRNASAQLDDEN 415

Query: 1123 K--KCSCS---------DQTGQCTCKVNVEGIHCDRCRPG 1151
               +C C+         + +G C CK    G  CD C PG
Sbjct: 416  VCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCDECLPG 455



 Score = 45.4 bits (106), Expect = 9e-04
 Identities = 31/110 (28%), Positives = 41/110 (37%), Gaps = 22/110 (20%)

Query: 1079 CNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCD---SETKKCSCSDQTGQCT 1135
            C C    +G  C +C + +   P        +P   A TC    S    C C   + +C+
Sbjct: 315  CECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCS 374

Query: 1136 ------------CKVNVEGIHCDRCRPGKF-----GLDAKNPLGCSSCYC 1168
                        CK N  G HC+ CR G F      LD +N   C  CYC
Sbjct: 375  YIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENV--CIECYC 422



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 36/138 (26%), Positives = 50/138 (36%), Gaps = 39/138 (28%)

Query: 425 VCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTG----------YPDCKACNC-SG 473
           VCV D           +C C+    G  C +C + Y G           P   A  C   
Sbjct: 305 VCVYDNSKL-------TCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPS 357

Query: 474 LGSKNEDPCFGP--------------CI-CKENVEGGDCSRCKSGFF---NLQEDNWKGC 515
           + S     CFG               C+ CK N  G  C  C+ G+F   + Q D+   C
Sbjct: 358 ISSIGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVC 417

Query: 516 DECFCS---GVSNRCQSS 530
            EC+C+    + +RC  S
Sbjct: 418 IECYCNPLGSIHDRCNGS 435



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 51/209 (24%), Positives = 67/209 (32%), Gaps = 52/209 (24%)

Query: 344 CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFF-RPKG 402
           C C+  A  C YD +                  +   C  NT G +C  C   +  RP  
Sbjct: 297 CKCNLHATVCVYDNSK-----------------LTCECEHNTTGPDCGKCKKNYQGRPWS 339

Query: 403 VSPNYPRP------CQPC-----HCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGV 451
                P P      C P      +C+  G  N     D  +    ++     CK    G 
Sbjct: 340 PGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTVICVS-----CKHNTRGQ 394

Query: 452 SCDRCARGYTGYPD--------CKACNCSGLGSKNEDPCFGP--CICKENVEGGDCSRCK 501
            C+ C  GY             C  C C+ LGS + D C G   C CK    G  C  C 
Sbjct: 395 HCELCRLGYFRNASAQLDDENVCIECYCNPLGSIH-DRCNGSGFCECKTGTTGPKCDECL 453

Query: 502 SGFFNLQEDNWK-GCDECFCSGVSNRCQS 529
            G      ++W  GC    C      CQ+
Sbjct: 454 PG------NSWHYGCQPNVCDNELLHCQN 476


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 132,391,756
Number of Sequences: 37866
Number of extensions: 7034002
Number of successful extensions: 43256
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 1068
Number of HSP's that attempted gapping in prelim test: 25606
Number of HSP's gapped (non-prelim): 8809
length of query: 3122
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3001
effective length of database: 13,665,732
effective search space: 41010861732
effective search space used: 41010861732
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.