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Search of human proteins with 26006461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
(778 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens] 1553 0.0
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens] 1134 0.0
gi|166295173 kin of IRRE like [Homo sapiens] 616 e-176
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 442 e-124
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 442 e-124
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 400 e-111
gi|118572606 hemicentin 1 [Homo sapiens] 112 1e-24
gi|4758822 nephrin precursor [Homo sapiens] 112 2e-24
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 111 3e-24
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 106 7e-23
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 105 1e-22
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 99 1e-20
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 99 1e-20
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 99 1e-20
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 99 2e-20
gi|21686977 cell adhesion molecule 4 [Homo sapiens] 94 4e-19
gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens] 94 6e-19
gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens] 94 6e-19
gi|110349719 titin isoform N2-A [Homo sapiens] 92 2e-18
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 92 2e-18
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 89 2e-17
gi|19743806 roundabout 1 isoform b [Homo sapiens] 87 6e-17
gi|109150416 peroxidasin [Homo sapiens] 87 6e-17
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 87 6e-17
gi|4506569 roundabout 1 isoform a [Homo sapiens] 87 6e-17
gi|224994173 roundabout 1 isoform d [Homo sapiens] 86 2e-16
gi|224994171 roundabout 1 isoform c [Homo sapiens] 86 2e-16
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 86 2e-16
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 86 2e-16
gi|31543106 basal cell adhesion molecule isoform 1 precursor [Ho... 80 6e-15
>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
Length = 778
Score = 1553 bits (4021), Expect = 0.0
Identities = 778/778 (100%), Positives = 778/778 (100%)
Query: 1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 60
MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV
Sbjct: 1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 60
Query: 61 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 120
SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ
Sbjct: 61 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 120
Query: 121 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 180
DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS
Sbjct: 121 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 180
Query: 181 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 240
IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET
Sbjct: 181 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 240
Query: 241 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 300
SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR
Sbjct: 241 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 300
Query: 301 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 360
TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG
Sbjct: 301 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 360
Query: 361 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 420
NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP
Sbjct: 361 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 420
Query: 421 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 480
IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI
Sbjct: 421 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 480
Query: 481 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 540
STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV
Sbjct: 481 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 540
Query: 541 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 600
AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ
Sbjct: 541 AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 600
Query: 601 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD 660
LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD
Sbjct: 601 LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD 660
Query: 661 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS 720
LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS
Sbjct: 661 LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS 720
Query: 721 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 778
SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV
Sbjct: 721 SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 778
>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
Length = 600
Score = 1134 bits (2932), Expect = 0.0
Identities = 566/569 (99%), Positives = 567/569 (99%)
Query: 1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 60
MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV
Sbjct: 1 MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV 60
Query: 61 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 120
SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ
Sbjct: 61 SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ 120
Query: 121 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 180
DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS
Sbjct: 121 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 180
Query: 181 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 240
IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET
Sbjct: 181 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 240
Query: 241 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 300
SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR
Sbjct: 241 SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR 300
Query: 301 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 360
TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG
Sbjct: 301 TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG 360
Query: 361 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 420
NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP
Sbjct: 361 NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP 420
Query: 421 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 480
IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI
Sbjct: 421 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 480
Query: 481 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 540
STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV
Sbjct: 481 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV 540
Query: 541 AVGAGVAFLVLMATIVAFCCARSQRNLKG 569
AVGAGVAFLVLMATIVAFCCARSQR+ G
Sbjct: 541 AVGAGVAFLVLMATIVAFCCARSQRSTGG 569
>gi|166295173 kin of IRRE like [Homo sapiens]
Length = 757
Score = 616 bits (1588), Expect = e-176
Identities = 340/760 (44%), Positives = 459/760 (60%), Gaps = 42/760 (5%)
Query: 43 NEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVV 102
++G FSQ+P DQ VV+GQ L C + Y G V W KDGLALG+G+ L ++P+Y VV
Sbjct: 16 SQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVV 75
Query: 103 GNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRA 162
G+ +G+++L+I AEL DDA YECQA +AA+RSR A+LTVL+PP+D I GGPVI L+A
Sbjct: 76 GSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQA 135
Query: 163 GDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
G P NLTC A NAKPAA+IIW R G GA S LL+DGKRE+ VS L I+P D++ G
Sbjct: 136 GTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIG 195
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQY 282
+ CR+ N+AIP GKETS+ +D+ HPP V LS+EPQ V E V F C A ANP + Y
Sbjct: 196 RVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGY 255
Query: 283 RWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQ 342
RWAK G +I++A Y T VDY++F+EPVSCEV N +GSTN+S V+V+F PR+ +P+
Sbjct: 256 RWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPK 315
Query: 343 SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVV 402
D+GSD +C W GNP LT+ W K+ S +VLSN L LKSV Q DAG Y CRA+V
Sbjct: 316 PTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIV 375
Query: 403 PRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLES 462
PR+G EREV L VNGPPIISS Q+A+ G+ G+++CFI STPPPDRIAW+WKEN LE
Sbjct: 376 PRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEV 435
Query: 463 GTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMK 522
GT RYTVE ++ GV+STLTI+N++ ADFQT YNCTAWNSFG T II+L+E+
Sbjct: 436 GTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEER----- 490
Query: 523 SGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIV 582
E +P+ +I G +GA + + +V F R + + K V K DI+VE V
Sbjct: 491 -------EVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETV 543
Query: 583 HKEPASGREGEEHSTIKQLMMDR------GEFQQDSVLKQ-LEVLKEEEKEFQNLKDPTN 635
++EP + E T R F+ D LKQ L + +E +KDPTN
Sbjct: 544 NREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTN 603
Query: 636 GYYSVNTFKEHHSTPTISLSSCQP------DLRPAGKQRVPTGMSFTNIYSTLSGQGRLY 689
GYY+V ++ S+ + + + D RP+ + +G + N YS +G
Sbjct: 604 GYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYS----RGPAS 659
Query: 690 DYGQR-------FVLGMGSSSIELCE--REFQRGSLSDSSSFLDTQC--DSSVSSSGKQD 738
DYG G ++S E +F ++ + + + S ++
Sbjct: 660 DYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERT 719
Query: 739 GYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 778
Y +D K + ++ +SQ+SD + Q+RMQTHV
Sbjct: 720 PYEAYDPIGKYATAT--RFSYTSQHSDYGQRFQQRMQTHV 757
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 442 bits (1137), Expect = e-124
Identities = 252/601 (41%), Positives = 342/601 (56%), Gaps = 30/601 (4%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
F QQP+D VV+ G+ L CA+ Y G V W K GLALG RDL + +Y + GN +G+
Sbjct: 26 FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
Query: 110 HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLT 169
H L I EL+D+A YECQA QA +RSRPA+L VLVPP+ P +LGGP +SL AG P NLT
Sbjct: 86 HDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 145
Query: 170 CHA-DNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
C + +A+P ++W R G +++GAT+ +TLL++G S+ STL ++P ++G + VCR
Sbjct: 146 CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 205
Query: 229 ATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
A ++A+P G++T++T+ +Q+PP V LS P V E V F C A A P VT YRWAK G
Sbjct: 206 ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG 265
Query: 289 QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDL 348
+ A G D ++ +EPVSCEV+NA+GS N S +DV FGP + +P+ + VD+
Sbjct: 266 SPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDV 325
Query: 349 GSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVG-- 406
G DA FSCAW GNP + W +RG VL + TL L SV EDAG YVCRA G
Sbjct: 326 GEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLR 385
Query: 407 AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSG 466
G E LTVN PP++++ + A +++C + ++P PD + WSW E LE+G+ G
Sbjct: 386 GGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQG 445
Query: 467 RYTVETISTEE-------GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGS 519
R+ VET E G+IS L IS +DF +NC+A N RL E G+
Sbjct: 446 RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARN---------RLGEGGA 496
Query: 520 EMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRV 579
+ A L + V I V A L+++ T VA CC R + KN +R+
Sbjct: 497 Q----ASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRI 552
Query: 580 EIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYS 639
+ +S R EE T + DRG V L EEK KDPTNGYY
Sbjct: 553 P-GSSDGSSSRGPEEEETGSR--EDRGPI----VHTDHSDLVLEEKGTLETKDPTNGYYK 605
Query: 640 V 640
V
Sbjct: 606 V 606
Score = 39.7 bits (91), Expect = 0.011
Identities = 50/200 (25%), Positives = 74/200 (37%), Gaps = 27/200 (13%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG-----------------SGVVL 377
P +P+ L+V LG +A CA L + W K G SG
Sbjct: 24 PHFLQQPEDLVVLLGEEARLPCALGAYWGL-VQWTKSGLALGGQRDLPGWSRYWISGNAA 82
Query: 378 SNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP---PIISSTQTQHALHGE 434
+ + L ++ V ED Y C+A + G R L V P P + + + G
Sbjct: 83 NGQHDLHIRPVELEDEASYECQAT--QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
Query: 435 KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQ 494
+ C R P +++ VL G + T+ T V STLT++ D
Sbjct: 141 PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 200
Query: 495 TIYNCTAWNS---FGSDTEI 511
T + C A + G DT I
Sbjct: 201 T-FVCRARSQALPTGRDTAI 219
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 442 bits (1137), Expect = e-124
Identities = 252/601 (41%), Positives = 342/601 (56%), Gaps = 30/601 (4%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
F QQP+D VV+ G+ L CA+ Y G V W K GLALG RDL + +Y + GN +G+
Sbjct: 26 FLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQ 85
Query: 110 HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLT 169
H L I EL+D+A YECQA QA +RSRPA+L VLVPP+ P +LGGP +SL AG P NLT
Sbjct: 86 HDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 145
Query: 170 CHA-DNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
C + +A+P ++W R G +++GAT+ +TLL++G S+ STL ++P ++G + VCR
Sbjct: 146 CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 205
Query: 229 ATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
A ++A+P G++T++T+ +Q+PP V LS P V E V F C A A P VT YRWAK G
Sbjct: 206 ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG 265
Query: 289 QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDL 348
+ A G D ++ +EPVSCEV+NA+GS N S +DV FGP + +P+ + VD+
Sbjct: 266 SPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDV 325
Query: 349 GSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVG-- 406
G DA FSCAW GNP + W +RG VL + TL L SV EDAG YVCRA G
Sbjct: 326 GEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLR 385
Query: 407 AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSG 466
G E LTVN PP++++ + A +++C + ++P PD + WSW E LE+G+ G
Sbjct: 386 GGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQG 445
Query: 467 RYTVETISTEE-------GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGS 519
R+ VET E G+IS L IS +DF +NC+A N RL E G+
Sbjct: 446 RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARN---------RLGEGGA 496
Query: 520 EMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRV 579
+ A L + V I V A L+++ T VA CC R + KN +R+
Sbjct: 497 Q----ASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRI 552
Query: 580 EIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYS 639
+ +S R EE T + DRG V L EEK KDPTNGYY
Sbjct: 553 P-GSSDGSSSRGPEEEETGSR--EDRGPI----VHTDHSDLVLEEKGTLETKDPTNGYYK 605
Query: 640 V 640
V
Sbjct: 606 V 606
Score = 39.7 bits (91), Expect = 0.011
Identities = 50/200 (25%), Positives = 74/200 (37%), Gaps = 27/200 (13%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG-----------------SGVVL 377
P +P+ L+V LG +A CA L + W K G SG
Sbjct: 24 PHFLQQPEDLVVLLGEEARLPCALGAYWGL-VQWTKSGLALGGQRDLPGWSRYWISGNAA 82
Query: 378 SNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP---PIISSTQTQHALHGE 434
+ + L ++ V ED Y C+A + G R L V P P + + + G
Sbjct: 83 NGQHDLHIRPVELEDEASYECQAT--QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
Query: 435 KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQ 494
+ C R P +++ VL G + T+ T V STLT++ D
Sbjct: 141 PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 200
Query: 495 TIYNCTAWNS---FGSDTEI 511
T + C A + G DT I
Sbjct: 201 T-FVCRARSQALPTGRDTAI 219
>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
Length = 583
Score = 400 bits (1028), Expect = e-111
Identities = 229/560 (40%), Positives = 316/560 (56%), Gaps = 30/560 (5%)
Query: 91 RDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDP 150
R + + +Y + GN +G+H L I EL+D+A YECQA QA +RSRPA+L VLVPP+ P
Sbjct: 17 RGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP 76
Query: 151 VILGGPVISLRAGDPLNLTCHA-DNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIV 209
+LGGP +SL AG P NLTC + +A+P ++W R G +++GAT+ +TLL++G S+
Sbjct: 77 QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE 136
Query: 210 STLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTF 269
STL ++P ++G + VCRA ++A+P G++T++T+ +Q+PP V LS P V E V F
Sbjct: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
Query: 270 HCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV 329
C A A P VT YRWAK G + A G D ++ +EPVSCEV+NA+GS N S +
Sbjct: 197 LCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTAL 256
Query: 330 DVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVR 389
DV FGP + +P+ + VD+G DA FSCAW GNP + W +RG VL + TL L SV
Sbjct: 257 DVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVG 316
Query: 390 QEDAGKYVCRAVVPRVG--AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPP 447
EDAG YVCRA G G E LTVN PP++++ + A +++C + ++P
Sbjct: 317 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPA 376
Query: 448 PDRIAWSWKENVLESGTSGRYTVETISTEE-------GVISTLTISNIVRADFQTIYNCT 500
PD + WSW E LE+G+ GR+ VET E G+IS L IS +DF +NC+
Sbjct: 377 PDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCS 436
Query: 501 AWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCC 560
A N RL E G++ A L + V I V A L+++ T VA CC
Sbjct: 437 ARN---------RLGEGGAQ----ASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCC 483
Query: 561 ARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVL 620
R + KN +R+ + +S R EE T + DRG V L
Sbjct: 484 WRHSKASASFSEQKNLMRIP-GSSDGSSSRGPEEEETGSR--EDRGPI----VHTDHSDL 536
Query: 621 KEEEKEFQNLKDPTNGYYSV 640
EEK KDPTNGYY V
Sbjct: 537 VLEEKGTLETKDPTNGYYKV 556
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 112 bits (281), Expect = 1e-24
Identities = 138/492 (28%), Positives = 202/492 (41%), Gaps = 73/492 (14%)
Query: 59 VVSGQPVTLLCA------IPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHL 112
V+ GQ +TL C IPE WIK+ L Y+ V + S L
Sbjct: 901 VIEGQQLTLPCTLLAGNPIPERR----WIKNSAML-------LQNPYITVRSDGS----L 945
Query: 113 KILRAELQDDAVYECQAIQAA-IRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCH 171
I R +LQD Y C A A ++ + V V P + G ++S G P+ L C
Sbjct: 946 HIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT--IQHGQQILSTIEGIPVTLPCK 1003
Query: 172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATN 231
A + P S+IW +KGE+I+ ++ + DG S +SPG E+G+ VC ATN
Sbjct: 1004 A-SGNPKPSVIWSKKGELISTSSAKFSAGADG------SLYVVSPGGEESGE-YVCTATN 1055
Query: 232 KAIPGGKETSVTIDIQHPPLV-----NLSVEPQ---PVLEDNVVTFHCSAKANPAVTQYR 283
A ++ +T+ ++ P V LS + VL VT C K+ P
Sbjct: 1056 TAGYAKRKVQLTVYVR--PRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI-IT 1112
Query: 284 WAKRGQIIKEASGE-------VYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
WAK Q+I S + T T S C TN G+ + ++V+ P+
Sbjct: 1113 WAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPK 1172
Query: 337 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK-------TLTLKSVR 389
+ P+ L V +G C G P I W K GS +++ E TL++
Sbjct: 1173 IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQAT 1232
Query: 390 QEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS------STQTQHALHGEKGQIKCFIR 443
DAG Y C A G E E+TL V PP + +T Q + ++ + C +
Sbjct: 1233 PSDAGIYTCVA-TNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAK 1291
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
TP P W N E +GR +I E+G + L I+++ D Y C A N
Sbjct: 1292 GTPKP---TIKWLHNGRE--LTGREPGISI-LEDGTL--LVIASVTPYD-NGEYICVAVN 1342
Query: 504 SFGSDTEIIRLK 515
G+ LK
Sbjct: 1343 EAGTTERKYNLK 1354
Score = 106 bits (265), Expect = 7e-23
Identities = 135/528 (25%), Positives = 200/528 (37%), Gaps = 67/528 (12%)
Query: 14 FLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVY---SFSQQPQDQVVVSGQPVTLLC- 69
FL Q + G L + A RR + QV+ S + P + V+ TL C
Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACE 3826
Query: 70 --AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYEC 127
IP+ + W K+G L V ++ +SY L L I+ + D A YEC
Sbjct: 3827 ATGIPKPS--INWRKNGHLLNVDQNQNSY--------RLLSSGSLVIISPSVDDTATYEC 3876
Query: 128 QAIQAA-IRSRPARLTVLVPP---DDPVILGGPVISLRAGDPLNLTCHADNAKPAASIIW 183
A R LTV VPP D+P +++ A P +TC A P SI W
Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDF---LVTKHA--PAVITCTASGV-PFPSIHW 3930
Query: 184 LRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVT 243
+ G + +L G E + + L + C A N A G VT
Sbjct: 3931 TKNGIRLLPRGDGYRILSSGAIEILATQL-------NHAGRYTCVARNAA--GSAHRHVT 3981
Query: 244 IDIQHPPLVNLSVEPQP----VLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVY 299
+ + PP++ +PQP V+ +N + C A P+ W K G + +
Sbjct: 3982 LHVHEPPVI----QPQPSELHVILNNPILLPCEATGTPSPF-ITWQKEGINVNTSGRNHA 4036
Query: 300 RTTVDYTYFSEPVS-------CEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDA 352
S V C N G+ ++V P ++ + ++ +
Sbjct: 4037 VLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096
Query: 353 IFSCAWTGNPSLTIVWMKRGSGVVLS------NEKTLTLKSVRQEDAGKYVCRAVVPRVG 406
SC G P I W K G +V S + +L + V+ DAG Y C A G
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANV-AG 4155
Query: 407 AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSG 466
+ LTV+ PP I ST+ + ++ I + P I W K+NVL + G
Sbjct: 4156 SSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWK-KDNVLLANLLG 4214
Query: 467 RYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRL 514
+YT E L + N+V D Y C A N+ G DT + L
Sbjct: 4215 KYTAEPYGE-------LILENVVLED-SGFYTCVANNAAGEDTHTVSL 4254
Score = 106 bits (264), Expect = 9e-23
Identities = 136/492 (27%), Positives = 197/492 (40%), Gaps = 78/492 (15%)
Query: 54 PQDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
PQ V++ + L C +P + W KDG L ++ +Y ++ N
Sbjct: 3719 PQSLVILLNKSTVLECIAEGVPTPR--ITWRKDGAVLA-----GNHARYSILENGF---- 3767
Query: 111 HLKILRAELQDDAVYECQAIQAA-IRSRPARLTVLVPPDDPVILGGPV-ISLRAGDPLNL 168
L I A + D Y C A AA R L V VPP I GP +++ L
Sbjct: 3768 -LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS---IAPGPTNMTVIVNVQTTL 3823
Query: 169 TCHADNAKPAASIIWLRKGEVIN--GATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
C A P SI W + G ++N S LL G S + ISP V++ +
Sbjct: 3824 ACEATGI-PKPSINWRKNGHLLNVDQNQNSYRLLSSG------SLVIISPS-VDDTATYE 3875
Query: 227 CRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFH------CSAKANPAVT 280
C TN A G + +V + +Q PP S+ +P D +VT H C+A P
Sbjct: 3876 CTVTNGA--GDDKRTVDLTVQVPP----SIADEPT--DFLVTKHAPAVITCTASGVP-FP 3926
Query: 281 QYRWAKRG----------QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVD 330
W K G +I+ + E+ T +++ + +C NA GS + T+
Sbjct: 3927 SIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNH---AGRYTCVARNAAGSAHRHVTLH 3983
Query: 331 VYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKS--- 387
V+ P + +P L V L + + C TG PS I W K G V S L S
Sbjct: 3984 VHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGL 4043
Query: 388 ----VRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKG-QIKCFI 442
+EDAG Y+C A P G ++ L V PP+IS ++ + +K + C
Sbjct: 4044 QISRAVREDAGTYMCVAQNP-AGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA 4102
Query: 443 RSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAW 502
PPPD I W GR VE+I +L I+ + D Y C A
Sbjct: 4103 DGLPPPD-ITWH---------KDGRAIVESIRQRVLSSGSLQIAFVQPGD-AGHYTCMAA 4151
Query: 503 NSFGSDTEIIRL 514
N GS + +L
Sbjct: 4152 NVAGSSSTSTKL 4163
Score = 103 bits (257), Expect = 6e-22
Identities = 109/390 (27%), Positives = 168/390 (43%), Gaps = 52/390 (13%)
Query: 59 VVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKIL 115
VV PV L C IP + W+KDG +SS+ L V LSG L +
Sbjct: 2023 VVVNNPVRLECEARGIPAPS--LTWLKDG------SPVSSFSNGLQV---LSGGRILALT 2071
Query: 116 RAELQDDAVYECQAIQAA-IRSRPARLTVLVPPDDPVILGGPV-ISLRAGDPLNLTCHAD 173
A++ D Y C A+ AA + R L V VPP+ I+G +S+ + L C +D
Sbjct: 2072 SAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPN---IMGEEQNVSVLISQAVELLCQSD 2128
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKA 233
A P ++ WL+ G + K L + S++ I V++ C ATN A
Sbjct: 2129 -AIPPPTLTWLKDGHPL----LKKPGLSISENRSVLK---IEDAQVQDTGRYTCEATNVA 2180
Query: 234 IPGGKETSVTIDIQHPPLVNLSVE--PQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQ-I 290
G E + ++I PP + S E V+E N+++ C + P W K+G +
Sbjct: 2181 --GKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLI-WKKKGSPV 2237
Query: 291 IKEASGEV--------YRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMT---T 339
+ ++ G V + ++ + SC +N G+ + VY P +T +
Sbjct: 2238 LTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGS 2297
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG------SGV-VLSNEKTLTLKSVRQED 392
P ++V G C G P T+ WMK G GV +L L LK++ D
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSD 2357
Query: 393 AGKYVCRAVVPRVGAGEREVTLTVNGPPII 422
G+YVC A V G +++ L+V+ PP I
Sbjct: 2358 TGRYVCVA-VNVAGMTDKKYDLSVHAPPSI 2386
Score = 101 bits (252), Expect = 2e-21
Identities = 128/495 (25%), Positives = 198/495 (40%), Gaps = 67/495 (13%)
Query: 51 SQQPQDQVVVSGQPVTLLCAIPEYDGF----VLWIKDGLALGVGRDLSSYPQYLVVGNHL 106
S ++ V+ G ++ C DG + W++DG LG+ L+ +V
Sbjct: 3439 SMGTEEITVLKGSSTSMACIT---DGTPAPSMAWLRDGQPLGLDAHLTVSTHGMV----- 3490
Query: 107 SGEHHLKILRAELQDDAVYECQAI-QAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDP 165
L++L+AE +D Y C A +A S+ L VL PP IS+ +P
Sbjct: 3491 -----LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP 3545
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
L LTC A PA + W++ G + +TL G E L IS VE+
Sbjct: 3546 LELTCIASGI-PAPKMTWMKDGRPLPQTDQVQTL---GGGE----VLRISTAQVEDTGRY 3597
Query: 226 VCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQP--VLEDNVVTFHCSAKA--NPAVTQ 281
C A++ A KE V + + PP + + EP+ VL + VT C + A P +T
Sbjct: 3598 TCLASSPAGDDDKEYLVRVHV--PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 282 YRWAKRGQI---IKEASGEVYRT--------TVDYTYFSEPVSCEVTNALGSTNLSRTVD 330
R +R Q ++ SG Y T +YT C +N G T +
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYT-------CVASNIAGKTTREFILT 3708
Query: 331 VYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK-------TL 383
V P + PQSL++ L + C G P+ I W K G+ + ++ + L
Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFL 3768
Query: 384 TLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQT-QHALHGEKGQIKCFI 442
++S D G+Y+C A G R + L V+ PP I+ T + + + C
Sbjct: 3769 HIQSAHVTDTGRYLCMA-TNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEA 3827
Query: 443 RSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAW 502
P P I W K L + + + +S+ VI + ++ D Y CT
Sbjct: 3828 TGIPKPS-INWR-KNGHLLNVDQNQNSYRLLSSGSLVIISPSV------DDTATYECTVT 3879
Query: 503 NSFGSDTEIIRLKEQ 517
N G D + L Q
Sbjct: 3880 NGAGDDKRTVDLTVQ 3894
Score = 100 bits (250), Expect = 4e-21
Identities = 115/447 (25%), Positives = 188/447 (42%), Gaps = 44/447 (9%)
Query: 92 DLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPV 151
DL P ++ + L G LKI + D Y C AI A R+ ++T+ V PV
Sbjct: 739 DLELRPSTFLIIDPLLGL--LKIQETQDLDAGDYTCVAINEAGRAT-GKITLDVG-SPPV 794
Query: 152 ILGGPV-ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVS 210
+ P +S+ G + L C+ P +I W R + N +S+ +
Sbjct: 795 FIQEPADVSMEIGSNVTLPCYVQGY-PEPTIKWRR---LDNMPIFSRPFSVSSISQLRTG 850
Query: 211 TLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFH 270
LFI + + +C A N+ ET+VT+ PL+ +S V+E +T
Sbjct: 851 ALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLP 910
Query: 271 CSAKANPAVTQYRWAKRGQIIKE-------ASGEVYRTTVDYTYFSEPVSCEVTNALGST 323
C+ A + + RW K ++ + + G ++ V E +C +N G+
Sbjct: 911 CTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGE-YTCVASNVAGTN 969
Query: 324 NLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK-- 381
N + +V V+ P + Q L G C +GNP +++W K+G + S+ K
Sbjct: 970 NKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFS 1029
Query: 382 -----TLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQ-------- 428
+L + S E++G+YVC A G +R+V LTV P + Q
Sbjct: 1030 AGADGSLYVVSPGGEESGEYVCTA-TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVE 1088
Query: 429 -HALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISN 487
L GE+ + C ++S PPP I W+ KE L S S R+T ++ I+
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPP-IITWA-KETQLISPFSPRHTFLP-------SGSMKITE 1139
Query: 488 IVRADFQTIYNCTAWNSFGSDTEIIRL 514
R +Y C A N G+ T+ ++L
Sbjct: 1140 -TRTSDSGMYLCVATNIAGNVTQAVKL 1165
Score = 95.5 bits (236), Expect = 2e-19
Identities = 120/478 (25%), Positives = 198/478 (41%), Gaps = 60/478 (12%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIPEYD-GFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
S + +P D +V P + C + W K+G+ L D G +
Sbjct: 3898 SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGD----------GYRIL 3947
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGDPL 166
++IL +L Y C A AA + R L + PVI P + + +P+
Sbjct: 3948 SSGAIEILATQLNHAGRYTCVARNAAGSAH--RHVTLHVHEPPVIQPQPSELHVILNNPI 4005
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
L C A P+ I W ++G +N + + +L G L IS E+ + +
Sbjct: 4006 LLPCEATGT-PSPFITWQKEGINVNTSGRNHAVLPSGG-------LQISRAVREDAGTYM 4057
Query: 227 CRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAK 286
C A N A G + +++Q PP+++ ++ + D +T C A P W K
Sbjct: 4058 CVAQNPA--GTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPP-PDITWHK 4114
Query: 287 RGQIIKEASGE-VYRTTVDYTYFSEP-----VSCEVTNALGSTNLSRTVDVYFGPRMTTE 340
G+ I E+ + V + F +P +C N GS++ S + V+ PR+ +
Sbjct: 4115 DGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRST 4174
Query: 341 PQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSN---------EKTLTLKSVRQE 391
V+ S AI C G P+ I W K V+L+N L L++V E
Sbjct: 4175 EGHYTVNENSQAILPCVADGIPTPAINWKK--DNVLLANLLGKYTAEPYGELILENVVLE 4232
Query: 392 DAGKYVCRAVVPRVGAGE--REVTLTVNGPPIISSTQTQHALH-GEKGQIKCFIRSTPPP 448
D+G Y C V AGE V+LTV+ P + +L+ GE+ ++ C P P
Sbjct: 4233 DSGFYTC---VANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLP 4289
Query: 449 DRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFG 506
++ W++ N++ + ++++ S L I + + D T Y CTA NS G
Sbjct: 4290 -KLTWTFNNNIIPA------HFDSVNGH----SELVIERVSKEDSGT-YVCTAENSVG 4335
Score = 91.7 bits (226), Expect = 2e-18
Identities = 124/495 (25%), Positives = 196/495 (39%), Gaps = 72/495 (14%)
Query: 53 QPQDQVVVSGQPVTLLCAIPEYDG-FVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHH 111
+P + V++G+ VTL C + + W K+ + S +L G+
Sbjct: 1085 KPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLIS---PFSPRHTFLPSGS------- 1134
Query: 112 LKILRAELQDDAVYECQAIQAAIR-SRPARLTVLVPPDDPVILGGPV-ISLRAGDPLNLT 169
+KI D +Y C A A ++ +L V VPP I GP + ++ G +++
Sbjct: 1135 MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPK---IQRGPKHLKVQVGQRVDIP 1191
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRE--SIVSTLFISPGDVENGQSIVC 227
C+A P I W + G T+L DG+ + TL I + C
Sbjct: 1192 CNAQGT-PLPVITWSKGGS---------TMLVDGEHHVSNPDGTLSIDQATPSDAGIYTC 1241
Query: 228 RATNKAIPGGKETSVTIDIQHPPLVNLSVEP------QPVLEDNVVTFHCSAKANPAVTQ 281
ATN I G ET +T+ +Q PP V +EP Q + + + F C AK P T
Sbjct: 1242 VATN--IAGTDETEITLHVQEPPTVE-DLEPPYNTTFQERVANQRIEFPCPAKGTPKPT- 1297
Query: 282 YRWAKRGQ----------IIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDV 331
+W G+ I+++ + V + Y + C N G+T + V
Sbjct: 1298 IKWLHNGRELTGREPGISILEDGTLLVIASVTPYD--NGEYICVAVNEAGTTERKYNLKV 1355
Query: 332 YFGPRMTTEPQ--SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVV-------LSNEKT 382
+ P + + Q ++ V L C G PS I+W K V ++N K
Sbjct: 1356 HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKI 1415
Query: 383 LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH---GEKGQIK 439
L L EDAG+Y C+A + G ++ + V PP I T + + ++
Sbjct: 1416 LKLFRATPEDAGRYSCKA-INIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALE 1474
Query: 440 CFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNC 499
C ++ TP PD I W L G VE + + L + N R D + Y C
Sbjct: 1475 CQVKGTPFPD-IHWFKDGKPLFLGDP---NVELLDRGQ----VLHLKNARRND-KGRYQC 1525
Query: 500 TAWNSFGSDTEIIRL 514
T N+ G + I+L
Sbjct: 1526 TVSNAAGKQAKDIKL 1540
Score = 87.4 bits (215), Expect = 5e-17
Identities = 123/489 (25%), Positives = 195/489 (39%), Gaps = 63/489 (12%)
Query: 54 PQDQVVVSGQPVTLLCAI---PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
P + VV + V L C + P D + W KDG L +G + L G L
Sbjct: 1460 PNEVSVVLNRDVALECQVKGTPFPD--IHWFKDGKPLFLG---DPNVELLDRGQVL---- 1510
Query: 111 HLKILRAELQDDAVYECQAIQAAIR-SRPARLTVLVPPDDPVILGGPV---ISLRAGDPL 166
HLK A D Y+C AA + ++ +LT+ +PP I GG V IS+ +
Sbjct: 1511 HLK--NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPS---IKGGNVTTDISVLINSLI 1565
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
L C P +I W + G+ I + S+ L D + L I V + +
Sbjct: 1566 KLECET-RGLPMPAITWYKDGQPIMSS--SQALYIDKGQY-----LHIPRAQVSDSATYT 1617
Query: 227 CRATNKAIPGGKETSVTIDIQHPPLV--NLSVE-PQPVLEDNVVTFHCSAKANPAVTQYR 283
C N A G E S +D+ PP++ NL+ + V+ + +T C A NP+
Sbjct: 1618 CHVANVA--GTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI-LT 1674
Query: 284 WAKRGQIIK-------EASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
W K G +K EA G+ C T+ G + VDV P
Sbjct: 1675 WLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPA 1734
Query: 337 MT--TEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV-------VLSNEKTLTLKS 387
+ E +V + + C TG+P TI+W+K G + +L N + L +
Sbjct: 1735 IEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQ 1794
Query: 388 VRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISST--QTQHALHGEKGQIKCFIRST 445
+ + G Y C A G ++E +TV+ PP I S+ + + + ++C
Sbjct: 1795 AQVSNTGLYRCMA-ANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGI 1853
Query: 446 PPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSF 505
P P I W K++ + G +++ + TL + + R Y C A N+
Sbjct: 1854 PNPS-ITW-LKDDQPVNTAQGNLKIQSSGRVLQIAKTL-LEDAGR------YTCVATNAA 1904
Query: 506 GSDTEIIRL 514
G + I+L
Sbjct: 1905 GETQQHIQL 1913
Score = 85.5 bits (210), Expect = 2e-16
Identities = 109/432 (25%), Positives = 180/432 (41%), Gaps = 58/432 (13%)
Query: 53 QPQDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
+ Q+ V+ Q V LLC AIP + W+KDG L LS V
Sbjct: 2109 EEQNVSVLISQAVELLCQSDAIPPPT--LTWLKDGHPLLKKPGLSISENRSV-------- 2158
Query: 110 HHLKILRAELQDDAVYECQAIQAAIRS-RPARLTVLVPPDDPVILGGP----VISLRAGD 164
LKI A++QD Y C+A A ++ + + + VPP+ +GG +++ G+
Sbjct: 2159 --LKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN----IGGSDELTQLTVIEGN 2212
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
++L C + P ++IW +KG + + + + G R+ L IS + +
Sbjct: 2213 LISLLCESSGIPPP-NLIWKKKGSPVLTDSMGRVRILSGGRQ-----LQISIAEKSDAAL 2266
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVL--EDNVVTFHCSAKANPAVTQY 282
C A+N A KE ++ + I+ P + N P ++ ++ C + P T
Sbjct: 2267 YSCVASNVAGTAKKEYNLQVYIR-PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPT-V 2324
Query: 283 RWAKRGQIIKEASG-----EVYRTTVDYTYFSEP--VSCEVTNALGSTNLSRTVDVYFGP 335
W K G + +A G E + + + S+ C N G T+ + V+ P
Sbjct: 2325 TWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPP 2384
Query: 336 RMT---TEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE-------KTLTL 385
+ P+++ V + +C +G P +I W K G V LSN + L L
Sbjct: 2385 SIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRL 2444
Query: 386 KSVRQEDAGKYVCRAVVPRVGAGEREV-TLTVNGPPIISSTQTQHALHGEKGQ---IKCF 441
EDAG+Y C VV ER++ L+V PP I T + ++ Q + C
Sbjct: 2445 MQTTMEDAGQYTC--VVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCE 2502
Query: 442 IRSTPPPDRIAW 453
+ P P+ I W
Sbjct: 2503 VTGNPVPE-ITW 2513
Score = 84.7 bits (208), Expect = 3e-16
Identities = 96/422 (22%), Positives = 167/422 (39%), Gaps = 48/422 (11%)
Query: 56 DQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 114
++ V+ PV L C A + W KD L ++ L+ + I
Sbjct: 1929 NETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMT----------FLNRGQIIDI 1978
Query: 115 LRAELQDDAVYECQAIQAAIRSRP-ARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHAD 173
A++ D +Y+C AI +A + L V V P + ++++ +P+ L C A
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS--ISGSNNMVAVVVNNPVRLECEA- 2035
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKA 233
PA S+ WL+ G ++ + +L G+ L ++ + + C A N A
Sbjct: 2036 RGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR------ILALTSAQISDTGRYTCVAVNAA 2089
Query: 234 IPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKE 293
G K+ + + + PP + + VL V C + A P T W K G + +
Sbjct: 2090 --GEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPT-LTWLKDGHPLLK 2146
Query: 294 ASG-------EVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRM--TTEPQSL 344
G V + + +CE TN G T + V+++ P + + E L
Sbjct: 2147 KPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQL 2206
Query: 345 LVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV---------VLSNEKTLTLKSVRQEDAGK 395
V G+ C +G P ++W K+GS V +LS + L + + DA
Sbjct: 2207 TVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAAL 2266
Query: 396 YVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQH----ALHGEKGQIKCFIRSTPPPDRI 451
Y C A G ++E L V P I+++ + G+ ++C ++ PPP +
Sbjct: 2267 YSCVA-SNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPP-TV 2324
Query: 452 AW 453
W
Sbjct: 2325 TW 2326
Score = 84.3 bits (207), Expect = 4e-16
Identities = 129/491 (26%), Positives = 193/491 (39%), Gaps = 73/491 (14%)
Query: 59 VVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKIL 115
V G V+L C A+P + W K+G + S++ + L G L H+K
Sbjct: 3071 VREGTSVSLECESNAVPP--PVITWYKNGRMITE----STHVEILADGQML----HIK-- 3118
Query: 116 RAELQDDAVYECQAIQAAIRS-RPARLTVLVPPDDPVILGGP---VISLRAGDPLNLTCH 171
+AE+ D Y C+AI A R + L V VPP + GP VI +P+ LTC
Sbjct: 3119 KAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPS----IEGPEREVIVETISNPVTLTCD 3174
Query: 172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATN 231
A P +I WL+ + I + + + G S L I+ + + C A+N
Sbjct: 3175 ATGIPPP-TIAWLKNHKRIENSDSLEVRILSGG-----SKLQIARSQHSDSGNYTCIASN 3228
Query: 232 KAIPGGKETSVTIDIQHPPLVNLSVEPQPV---LEDNVVTFHCSAKANPAVTQYRWAKRG 288
+ G + + IQ PP V + P V L +NV C+A P +W K G
Sbjct: 3229 --MEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELV-CNANGIPTPL-IQWLKDG 3284
Query: 289 QIIKEASGEVYRTTVD-----------YTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRM 337
+ I ASGE R V T + +C TN G + ++VY P +
Sbjct: 3285 KPI--ASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTI 3342
Query: 338 T---TEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTL-----TLKSVR 389
E + L+ + + C TG P I W+K G + LS+ L ++ VR
Sbjct: 3343 RGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVR 3402
Query: 390 QE--DAGKYVCRAVVPRVGAGEREVTLTVNGPPIISS---TQTQHALHGEKGQIKCFIRS 444
+ D Y C A R G + L V PP + + T+ L G + C
Sbjct: 3403 AQVSDVAVYTCVA-SNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDG 3461
Query: 445 TPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNS 504
TP P + +W + G TV T G++ L + + Y C A N
Sbjct: 3462 TPAP---SMAWLRDGQPLGLDAHLTVST----HGMVLQLLKA---ETEDSGKYTCIASNE 3511
Query: 505 FGSDTEIIRLK 515
G ++ LK
Sbjct: 3512 AGEVSKHFILK 3522
Score = 76.6 bits (187), Expect = 8e-14
Identities = 119/499 (23%), Positives = 181/499 (36%), Gaps = 65/499 (13%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIPEY-DGFVLWIKDGLALGVGRDLSSYP----QYLVVGN 104
F Q+P D + G VTL C + Y + + W R L + P + V
Sbjct: 795 FIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW----------RRLDNMPIFSRPFSVSSI 844
Query: 105 HLSGEHHLKILRAELQDDAVYECQAIQ--AAIRSR-PARLTVLVPPDDPVILGGPVISLR 161
L IL D Y C+A I+S +T LV P + + V ++
Sbjct: 845 SQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP--LIGISPSVANVI 902
Query: 162 AGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVEN 221
G L L C P W++ ++ Y T+ DG +L I +++
Sbjct: 903 EGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYI-TVRSDG-------SLHIERVQLQD 954
Query: 222 GQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQ 281
G C A+N A K TSV + + P + + +E VT C A NP +
Sbjct: 955 GGEYTCVASNVAGTNNKTTSVVVHVL--PTIQHGQQILSTIEGIPVTLPCKASGNPKPSV 1012
Query: 282 YRWAKRGQIIKEASGEVYRTTVDYTYFSEP-------VSCEVTNALGSTNLSRTVDVYFG 334
W+K+G++I +S + Y P C TN G + VY
Sbjct: 1013 I-WSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVR 1071
Query: 335 PRM--------TTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK----- 381
PR+ +P + V G + C P I W K + + +
Sbjct: 1072 PRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLP 1131
Query: 382 --TLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH-GEKGQI 438
++ + R D+G Y+C A G + V L V+ PP I + G++ I
Sbjct: 1132 SGSMKITETRTSDSGMYLCVA-TNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDI 1190
Query: 439 KCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYN 498
C + TP P +W + G + V S +G TL+I +D IY
Sbjct: 1191 PCNAQGTPLP---VITWSKGGSTMLVDGEHHV---SNPDG---TLSIDQATPSD-AGIYT 1240
Query: 499 CTAWNSFGSDTEIIRLKEQ 517
C A N G+D I L Q
Sbjct: 1241 CVATNIAGTDETEITLHVQ 1259
Score = 72.0 bits (175), Expect = 2e-12
Identities = 120/528 (22%), Positives = 199/528 (37%), Gaps = 74/528 (14%)
Query: 45 GQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVL-WIKDGLALGVGRDLSSYPQYLVVG 103
G + + + + V+ P++L C L W KDG L+S + L+
Sbjct: 2775 GNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG------HPLTSSDKVLI-- 2826
Query: 104 NHLSGEHHLKILRAELQDDAVYECQAI-QAAIRSRPARLTVLVPPDDPVILGG-----PV 157
L G L+I RA+++D Y C A+ +A S + VLVPP +I G
Sbjct: 2827 --LPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP---IIKGANSDLPEE 2881
Query: 158 ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPG 217
+++ + C + PA W + G+ + + K L +G+ I++T G
Sbjct: 2882 VTVLVNKSALIEC-LSSGSPAPRNSWQKDGQPLLEDDHHK-FLSNGRILQILNTQITDIG 2939
Query: 218 DVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANP 277
VC A N A K ++ + + P ++ E V+ +N ++ C P
Sbjct: 2940 ------RYVCVAENTAGSAKKYFNLNVHVP-PSVIGPKSENLTVVVNNFISLTCEVSGFP 2992
Query: 278 AVTQYRWAKRGQIIKEASG----------EVYRTTV----DYTYFSEPVSCEVTNALGST 323
W K Q IK + ++ R V +YT C N G +
Sbjct: 2993 P-PDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYT-------CIAINQAGES 3044
Query: 324 NLSRTVDVYFGPRMTTEPQSLL----VDLGSDAIFSCAWTGNPSLTIVWMKRGSGV---- 375
++ VY P + L V G+ C P I W K G +
Sbjct: 3045 KKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITEST 3104
Query: 376 ---VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH 432
+L++ + L +K D G+YVCRA + G ++ L V PP I + + +
Sbjct: 3105 HVEILADGQMLHIKKAEVSDTGQYVCRA-INVAGRDDKNFHLNVYVPPSIEGPEREVIVE 3163
Query: 433 GEKGQIKCFIRSTP-PPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRA 491
+ +T PP IAW +E+ S +E G S L I+ +
Sbjct: 3164 TISNPVTLTCDATGIPPPTIAWLKNHKRIENSDS----LEVRILSGG--SKLQIARSQHS 3217
Query: 492 DFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIG 539
D Y C A N G + L Q +GA + ++ ++V++G
Sbjct: 3218 DSGN-YTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD---VSVLLG 3261
Score = 68.2 bits (165), Expect = 3e-11
Identities = 78/308 (25%), Positives = 123/308 (39%), Gaps = 53/308 (17%)
Query: 119 LQDDAVYECQAIQAAIR-SRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKP 177
L+D Y C A AA + LTV V P + G +SL G+ L L+C A P
Sbjct: 4231 LEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGD--VSLNKGEQLRLSCKATGI-P 4287
Query: 178 AASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGG 237
+ W +I S +G E ++ + E+ + VC A N G
Sbjct: 4288 LPKLTWTFNNNIIPAHFDSV----NGHSELVIERV-----SKEDSGTYVCTAENSV--GF 4336
Query: 238 KETSVTIDIQHPPLVNLS-----VEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIK 292
+ + ++ PP+ +EP L N + +C K +P T +W ++G I+
Sbjct: 4337 VKAIGFVYVKEPPVFKGDYPSNWIEP---LGGNAI-LNCEVKGDPTPT-IQWNRKGVDIE 4391
Query: 293 EAS-------------GEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTT 339
+ G V DYT C TN G S ++ + P +T
Sbjct: 4392 ISHRIRQLGNGSLAIYGTVNEDAGDYT-------CVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV-------VLSNEKTLTLKSVRQED 392
EP +++ G I +C TG P TI W ++G + VLSN +L + ++ED
Sbjct: 4445 EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSN-NSLYIADAQKED 4503
Query: 393 AGKYVCRA 400
++ C A
Sbjct: 4504 TSEFECVA 4511
Score = 63.2 bits (152), Expect = 9e-10
Identities = 114/512 (22%), Positives = 186/512 (36%), Gaps = 98/512 (19%)
Query: 52 QQPQDQVVVSGQPVTLLCAIPEYDGFVL----WIKDGLALGVGRDLSSYPQYLVVGNHLS 107
+ P++ VV V+L C E G L W KDG + + + LS
Sbjct: 2391 RSPENISVVEKNSVSLTC---EASGIPLPSITWFKDGWPVSLSNSVRI----------LS 2437
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIRSRPA-RLTVLVPPDDPVILGGPV---ISLRAG 163
G L++++ ++D Y C AA R L+VLVPP I+G + ++
Sbjct: 2438 GGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPH---IVGENTLEDVKVKEK 2494
Query: 164 DPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVST---LFISPGDVE 220
+ LTC P I W + G+ L++ + I+S L I+ V
Sbjct: 2495 QSVTLTCEV-TGNPVPEITWHKDGQP----------LQEDEAHHIISGGRFLQITNVQVP 2543
Query: 221 NGQSIVCRATNKAIPGGKETSVTIDI-QHPPLVNLSVEPQP----VLEDNVVTFHCSAKA 275
+ C A++ A G K S ++++ P + + + P V+ ++ + C A +
Sbjct: 2544 HTGRYTCLASSPA--GHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYS 2601
Query: 276 NPAVTQYRWAKRGQIIKE-------ASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRT 328
P T W K G ++ G + + SC TN G
Sbjct: 2602 YPPAT-ITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYE 2660
Query: 329 VDVYFGPRMTT--------EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV----- 375
V VY P + P+ + + + + C PS ++ W K G +
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH 2720
Query: 376 --VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN---GPPIISSTQTQHA 430
+ +N TL +K + D G+Y C V AGE E+ VN P + +
Sbjct: 2721 VNIAANGHTLQIKEAQISDTGRYTC---VASNIAGEDELDFDVNIQVPPSFQKLWEIGNM 2777
Query: 431 LH-GEKGQIKCFIRSTP----------PPDRIAWSWKENVLESGTSGRYTVETISTEEGV 479
L G G+ K I + P PP + W + L T S + +
Sbjct: 2778 LDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL-----------TSSDKVLI 2826
Query: 480 ISTLTISNIVRADFQTI--YNCTAWNSFGSDT 509
+ + I RA + Y C A N G D+
Sbjct: 2827 LPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDS 2858
Score = 50.8 bits (120), Expect = 5e-06
Identities = 86/370 (23%), Positives = 144/370 (38%), Gaps = 48/370 (12%)
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P + C D+ P ++ ++R G + Y K ES L I+ + +
Sbjct: 446 PGQIPCSVDSLLPF-TLSFVRNGVTLGVDQYLK--------ESASVNLDIAKVTLSDEGF 496
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLV-----NLSVEPQPVLEDNVVTFHCSAKANPAV 279
C A + A G +T D+ PP V N++V P E V+T + + +
Sbjct: 497 YECIAVSSAGTGRAQTF--FDVSEPPPVIQVPNNVTVTPG---ERAVLTCLIISAVDYNL 551
Query: 280 TQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDV 331
T W + + ++ A RT + + + V C V++ GS+ S + V
Sbjct: 552 T---WQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTV 608
Query: 332 YFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVV------LSNEKTLTL 385
P++T P++ GS+ C+ TG P I W +V ++++ TL +
Sbjct: 609 QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFI 668
Query: 386 KSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH-GEKGQIKCFIRS 444
K+ +DAG Y C A G ++ TL P + Q++ + G+ ++C
Sbjct: 669 KNAAPKDAGIYGCLA-SNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSG 727
Query: 445 TPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNS 504
PPP W + LE S T I G++ ++ D Y C A N
Sbjct: 728 IPPPQ---VKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGD----YTCVAINE 777
Query: 505 FGSDTEIIRL 514
G T I L
Sbjct: 778 AGRATGKITL 787
>gi|4758822 nephrin precursor [Homo sapiens]
Length = 1241
Score = 112 bits (279), Expect = 2e-24
Identities = 100/376 (26%), Positives = 165/376 (43%), Gaps = 34/376 (9%)
Query: 20 LGLQKRGCCLVLGYMAKDKFRRMNEGQV-YSFSQQPQDQVVVSGQPVTLLCAIPEYDGFV 78
LG R L+LG + + + V F P++ VV G V L C + V
Sbjct: 3 LGTTLRASLLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAV 62
Query: 79 LWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQA----IQAAI 134
W KDGL LG + +P+Y + G+ GE HL I +L DDA YECQ + +
Sbjct: 63 QWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPEL 122
Query: 135 RSRPARLTVLVPPDDPVIL--GGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVING 192
S L++LVPP ++ G +++ AG + C + +AKPA I L G+ I+
Sbjct: 123 VSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISD 182
Query: 193 ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLV 252
+ + K ++ +T ++P +N Q +VC A++ A+ + S T+++ PP
Sbjct: 183 ISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-- 240
Query: 253 NLSVEPQPVLEDNVV------TFHCSAKANPAVTQYRWAKRGQIIKEASG-----EVYRT 301
V P L++ V C A+ + +W K GQ + A G V R+
Sbjct: 241 GPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS 300
Query: 302 TVDYTYFSE----PVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCA 357
+ T E +SCE N++ + + + T P S ++ LG S +
Sbjct: 301 VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITL-----QVTFPPSAIIILG-----SAS 350
Query: 358 WTGNPSLTIVWMKRGS 373
T N ++T+ + + S
Sbjct: 351 QTENKNVTLSCVSKSS 366
Score = 90.5 bits (223), Expect = 5e-18
Identities = 113/500 (22%), Positives = 189/500 (37%), Gaps = 53/500 (10%)
Query: 54 PQDQVVVSGQPVTLLCAI----PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
P+ Q + +G V L+C PE ++W KD + R + + SG
Sbjct: 450 PEGQKLRAGTRVRLVCLAIGGNPEPS--LMWYKDSRTVTESRLPQESRRVHLGSVEKSGS 507
Query: 110 ---HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPL 166
L ++ + A + C+A Q S +L V PP + IL +LR GD L
Sbjct: 508 TFSRELVLVTGPSDNQAKFTCKAGQL---SASTQLAVQFPPTNVTILAN-ASALRPGDAL 563
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
NLTC + ++ P ++ W ++GE + G + K + ++ + ++GQ +
Sbjct: 564 NLTCVSVSSNPPVNLSWDKEGERLEGVA-APPRRAPFKGSAAARSVLLQVSSRDHGQRVT 622
Query: 227 CRATNKAIPGGKETSVTIDIQH-PPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWA 285
CRA + + + +++ + P + V +E S ANPA + W
Sbjct: 623 CRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWT 682
Query: 286 KRGQIIKEASGEVYR------------TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYF 333
RG + A G +R T D + + C+ N+ G+ +DV++
Sbjct: 683 FRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQ--LHCQ--NSEGTAEARLRLDVHY 738
Query: 334 GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSL--TIVWMKRGSG-----------VVLSNE 380
P + V++G C NP L W + G +
Sbjct: 739 APTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPT 798
Query: 381 KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS--STQTQHALHGE---K 435
L + + AG Y C R + L V P + + T+ A G+
Sbjct: 799 GRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSS 858
Query: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSG-RYTVETISTEEGVISTLTISNIVRADFQ 494
+ C R P I ++W +N + RYT T S LTI+N+ A
Sbjct: 859 ATLHCRARGVP---NIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDY 915
Query: 495 TIYNCTAWNSFGSDTEIIRL 514
++ CTA N+ GSD I+L
Sbjct: 916 ALFTCTATNALGSDQTNIQL 935
Score = 62.4 bits (150), Expect = 2e-09
Identities = 86/377 (22%), Positives = 151/377 (40%), Gaps = 55/377 (14%)
Query: 129 AIQAAIRSRPARLTVLVPPDDPVIL--GGPVISLRAGDPLNLTCHADNAKPAASIIWLRK 186
A++A I++ + VL PP PVI G +RAG L L C A P A++ WL+
Sbjct: 223 ALEAPIKAS-FTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKN 281
Query: 187 GEVIN---GATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVT 243
G+ ++ G +++ + R V + + P D +G + C A N G +E +T
Sbjct: 282 GQPVSTAWGTEHTQAVARS------VLVMTVRPED--HGAQLSCEAHNSVSAGTQEHGIT 333
Query: 244 IDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKAN-PAVTQYRWAKRGQIIKEA-------- 294
+ + PP + + E+ VT C +K++ P V W Q++
Sbjct: 334 LQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLH 393
Query: 295 SGEVYRTTVDYTYFSE----PVSCEV-TNALGSTNLSRTVDV---YFGPRMTTE--PQSL 344
G + + + + E ++CE + A +++ + Y ++ E P+
Sbjct: 394 GGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQ 453
Query: 345 LVDLGSDAIFSC-AWTGNPSLTIVWMKRGSGVVLS----NEKTLTLKSVRQEDAGKYVCR 399
+ G+ C A GNP +++W K V S + + L SV E +G R
Sbjct: 454 KLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSV--EKSGSTFSR 511
Query: 400 AVVPRVGAGEREVTLTVNGPPIISSTQ--------------TQHALH-GEKGQIKCFIRS 444
+V G + + T + +STQ AL G+ + C S
Sbjct: 512 ELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVS 571
Query: 445 TPPPDRIAWSWKENVLE 461
+ PP ++W + LE
Sbjct: 572 SNPPVNLSWDKEGERLE 588
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 111 bits (277), Expect = 3e-24
Identities = 127/490 (25%), Positives = 191/490 (38%), Gaps = 58/490 (11%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+QP D +V G+P TL C A + W K+G + R+ + L+ L
Sbjct: 68 EQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPR 127
Query: 111 HLKILRAELQDDAVYECQAIQ--AAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNL 168
+ RA D+ VY C A A SR A L V V DD G V+ + G+P L
Sbjct: 128 IVHGRRAR-PDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVV-VAVGEPAVL 185
Query: 169 TCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
C P S+ W + G + + +R GK L +S + VC
Sbjct: 186 ECVPPRGHPEPSVSWRKDGARLKEEE-GRITIRGGK-------LMMSHTLKSDAGMYVCV 237
Query: 229 ATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
A+N A + + ++ P + V Q VL D VTF C K +P + RW K
Sbjct: 238 ASNMAGERESAAAEVMVLERPSFLRRPVN-QVVLADAPVTFLCEVKGDPP-PRLRWRKED 295
Query: 289 QIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDVYFGPRMTTE 340
+ Y D++ + VS C N++G S ++ V+ P++ T+
Sbjct: 296 GELPTGR---YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQ 352
Query: 341 PQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------SNEKTLTLK 386
PQ + G F C GNP I W K GS V+L S L +
Sbjct: 353 PQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNG-------PPIISSTQTQHALHGEKGQIK 439
+V++ DAG YVC+A V G+ + L + G P I+ Q + G +
Sbjct: 413 AVQRGDAGYYVCQA-VSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLP 471
Query: 440 CFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNC 499
C + P P + W L+ + + + TL I+N+ D Y+C
Sbjct: 472 CRVTGNPQPS-VRWKKDGQWLQG--------DDLQFKTMANGTLYIANVQEMD-MGFYSC 521
Query: 500 TAWNSFGSDT 509
A +S G T
Sbjct: 522 VAKSSTGEAT 531
Score = 63.9 bits (154), Expect = 5e-10
Identities = 97/389 (24%), Positives = 143/389 (36%), Gaps = 71/389 (18%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
F Q P + VV G+P L C P + V W KDG L + + G L
Sbjct: 168 FRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARL-----KEEEGRITIRGGKLM 222
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGD-PL 166
H LK D +Y C A A A V+V + P L PV + D P+
Sbjct: 223 MSHTLK------SDAGMYVCVASNMAGERESAAAEVMV-LERPSFLRRPVNQVVLADAPV 275
Query: 167 NLTCHADNAKPAASIIWLRK-GEVINGATYSKTLLRDGKRESIVS--TLFISPGDVENGQ 223
C P + W ++ GE+ G R I S +L+I E+
Sbjct: 276 TFLCEV-KGDPPPRLRWRKEDGELPTG------------RYEIRSDHSLWIGHVSAEDEG 322
Query: 224 SIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYR 283
+ C A N G E S ++ + PP + + Q V F C K NP +
Sbjct: 323 TYTCVAENSV--GRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIF- 379
Query: 284 WAKRG-QIIKEAS--------------GEVYRTTV---DYTYFSEPVSCEVTNALGSTNL 325
W K G Q++ S G++ T V D Y+ C+ + GS
Sbjct: 380 WQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYY----VCQAVSVAGSILA 435
Query: 326 SRTVDVY------FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV---- 375
+++ P + P + + LGS C TGNP ++ W K G +
Sbjct: 436 KALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD 495
Query: 376 ----VLSNEKTLTLKSVRQEDAGKYVCRA 400
++N TL + +V++ D G Y C A
Sbjct: 496 LQFKTMAN-GTLYIANVQEMDMGFYSCVA 523
Score = 52.4 bits (124), Expect = 2e-06
Identities = 92/388 (23%), Positives = 144/388 (37%), Gaps = 65/388 (16%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIP-EYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
SF ++P +QVV++ PVT LC + + + W K+ L GR +
Sbjct: 259 SFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGR------------YEIR 306
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIRSRPA-RLTVLVPPDDPVILGGPVISLRA-GDP 165
+H L I +D+ Y C A + R+ + L+V VPP ++ P + A G+
Sbjct: 307 SDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ---LVTQPQDQMAAPGES 363
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS- 224
+ C P +I W ++G + + L+ R S+ ++ V+ G +
Sbjct: 364 VAFQCET-KGNPPPAIFWQKEGSQV--LLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
Query: 225 -IVCRATNKAIPGGKETSVTIDIQH------PPLVNLSVEPQPVLEDNVVTFHCSAKANP 277
VC+A ++ G ++I+ PP++ Q ++ + V C NP
Sbjct: 421 YYVCQAV--SVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNP 478
Query: 278 AVTQYRWAKRGQIIK--------EASGEVYRTTV---DYTYFSEPVSCEVTNALGSTNLS 326
RW K GQ ++ A+G +Y V D ++S A S L
Sbjct: 479 Q-PSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLK 537
Query: 327 RTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLK 386
D P TEP S G PS +V + N TLT K
Sbjct: 538 MREDWGVSPDPPTEPSSP--------------PGAPSQPVV------TEITKNSITLTWK 577
Query: 387 SVRQEDAG--KYVCRAVVPRVGAGEREV 412
Q A YV A P G R V
Sbjct: 578 PNPQTGAAVTSYVIEAFSPAAGNTWRTV 605
Score = 35.4 bits (80), Expect = 0.20
Identities = 47/190 (24%), Positives = 64/190 (33%), Gaps = 28/190 (14%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE----KTLTLKS--- 387
PR+ +P LLV G A C G P I W K G+ V E L L S
Sbjct: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
Query: 388 ---------VRQEDAGKYVCRAVVPRVGAGEREVTL--TVNGPPIISSTQTQHALHGEKG 436
+ D G Y C A A R +L V S GE
Sbjct: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPA 183
Query: 437 QIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTI 496
++C P ++W K+ GR T+ L +S+ +++D +
Sbjct: 184 VLECVPPRGHPEPSVSWR-KDGARLKEEEGRITIRG--------GKLMMSHTLKSD-AGM 233
Query: 497 YNCTAWNSFG 506
Y C A N G
Sbjct: 234 YVCVASNMAG 243
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 106 bits (265), Expect = 7e-23
Identities = 137/529 (25%), Positives = 208/529 (39%), Gaps = 60/529 (11%)
Query: 33 YMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGR 91
Y+ D R E + P D +V G+P TL C A + W KDG + +
Sbjct: 16 YVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDK 75
Query: 92 DLSSYPQYLVVGNHLSGEHHLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVP 146
D + L+ L L+I+ R D+ Y C A + A+ SR A L V +
Sbjct: 76 DDPRSHRMLLPSGSL---FFLRIVHGRRSKPDEGSYVCVARNYLGEAV-SRNASLEVALL 131
Query: 147 PDDPVILGGPV-ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKR 205
DD P + + AG+P L C P +I W +K +V + +R GK
Sbjct: 132 RDD--FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYW-KKDKVRIDDKEERISIRGGK- 187
Query: 206 ESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDN 265
L IS + C TN + + + P + + Q VLE+
Sbjct: 188 ------LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPIN-QVVLEEE 240
Query: 266 VVTFHCSAKANPAVTQYRWAKRGQIIKEASGEV---YRTTVDYTYFSEPVS--CEVTNAL 320
V F C + +P T RW K + ++ Y + T ++ + C N +
Sbjct: 241 AVEFRCQVQGDPQPT-VRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRV 299
Query: 321 GSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--- 377
G S T+ V P+ P+ +V G F C GNP + W K GS +L
Sbjct: 300 GKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPN 359
Query: 378 -----------SNEKTLTLKSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPI 421
S LT+ ++++ DAG Y+C+A+ + + EVT LT PPI
Sbjct: 360 QPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPI 419
Query: 422 ISSTQTQHALHGE-KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI 480
I L + +KC P P I+W KE G R T++ E+G
Sbjct: 420 ILQGPANQTLAVDGTALLKCKATGDPLP-VISW-LKEGFTFPGRDPRATIQ----EQG-- 471
Query: 481 STLTISNIVRADFQTIYNCTAWNSFG--SDTEIIRLKEQGSEMKSGAGL 527
TL I N+ +D T Y C A +S G S + ++ + E G+ + L
Sbjct: 472 -TLQIKNLRISDTGT-YTCVATSSSGETSWSAVLDVTESGATISKNYDL 518
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 105 bits (263), Expect = 1e-22
Identities = 133/510 (26%), Positives = 203/510 (39%), Gaps = 60/510 (11%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+ P D +V G+P TL C A + W KDG + +D + L+ L
Sbjct: 51 EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL---F 107
Query: 111 HLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGD 164
L+I+ R D+ Y C A + A+ SR A L V + DD P + + AG+
Sbjct: 108 FLRIVHGRRSKPDEGSYVCVARNYLGEAV-SRNASLEVALLRDD--FRQNPTDVVVAAGE 164
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P L C P +I W +K +V + +R GK L IS +
Sbjct: 165 PAILECQPPRGHPEPTIYW-KKDKVRIDDKEERISIRGGK-------LMISNTRKSDAGM 216
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
C TN + + + P + + Q VLE+ V F C + +P T RW
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPIN-QVVLEEEAVEFRCQVQGDPQPT-VRW 274
Query: 285 AKRGQIIKEASGEV---YRTTVDYTYFSEPVS--CEVTNALGSTNLSRTVDVYFGPRMTT 339
K + ++ Y + T ++ + C N +G S T+ V P+
Sbjct: 275 KKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 334
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------SNEKTLTL 385
P+ +V G F C GNP + W K GS +L S LT+
Sbjct: 335 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 394
Query: 386 KSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPIISSTQTQHALHGE-KGQIK 439
++++ DAG Y+C+A+ + + EVT LT PPII L + +K
Sbjct: 395 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK 454
Query: 440 CFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNC 499
C P P I+W KE G R T++ E+G TL I N+ +D T Y C
Sbjct: 455 CKATGDPLP-VISW-LKEGFTFPGRDPRATIQ----EQG---TLQIKNLRISDTGT-YTC 504
Query: 500 TAWNSFG--SDTEIIRLKEQGSEMKSGAGL 527
A +S G S + ++ + E G+ + L
Sbjct: 505 VATSSSGETSWSAVLDVTESGATISKNYDL 534
Score = 65.1 bits (157), Expect = 2e-10
Identities = 104/485 (21%), Positives = 169/485 (34%), Gaps = 75/485 (15%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
F Q P D VV +G+P L C P + + W KD + + + S + G
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERIS-----IRGG--- 202
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIR--SRPARLTVLVPPDDPVILGGPVIS-LRAGD 164
L I D +Y C S PA LTV + P L P+ + +
Sbjct: 203 ---KLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF---ERPTFLRRPINQVVLEEE 256
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
+ C P ++ W + + Y ++D I T+ G +
Sbjct: 257 AVEFRCQV-QGDPQPTVRWKKDDADLPRGRYD---IKDDYTLRIKKTMSTDEG------T 306
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
+C A N+ G E S T+ ++ PP + Q V + VTF C K NP + W
Sbjct: 307 YMCIAENRV--GKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVF-W 363
Query: 285 AKRG---------------QIIKEASGEVYRTTV---DYTYFSEPVSCEVTNALGSTNLS 326
K G + +G++ T + D Y+ C+ GS
Sbjct: 364 QKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY----ICQALTVAGSILAK 419
Query: 327 RTVDVYF------GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG-------S 373
++V P + P + + + A+ C TG+P I W+K G
Sbjct: 420 AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP 479
Query: 374 GVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHG 433
+ + TL +K++R D G Y C A V IS L G
Sbjct: 480 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPG 539
Query: 434 --EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRA 491
K Q+ +++ + SW+ + + Y +E S + S T++N V+
Sbjct: 540 PPSKPQVTDVTKNS-----VTLSWQPGTPGTLPASAYIIEAFS-QSVSNSWQTVANHVKT 593
Query: 492 DFQTI 496
T+
Sbjct: 594 TLYTV 598
Score = 34.7 bits (78), Expect = 0.35
Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 16/84 (19%)
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV------------VLSNE 380
F PR+ P ++V G +C G P+ TI W K G V +L +
Sbjct: 45 FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104
Query: 381 KTLTLKSVR----QEDAGKYVCRA 400
L+ V + D G YVC A
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVA 128
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 99.4 bits (246), Expect = 1e-20
Identities = 123/455 (27%), Positives = 183/455 (40%), Gaps = 58/455 (12%)
Query: 78 VLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSR 137
V W KD AL +G ++ P G H L++ RA L D +Y C+A+ AA R +
Sbjct: 1778 VTWYKDSQALSLGEEVFLLP----------GTHTLQLGRARLSDSGMYTCEALNAAGRDQ 1827
Query: 138 P-ARLTVLVPPDDPVILGGP--VISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGAT 194
+L+VLVPP GP + +R GD L+C D A P ++ W + G+ + A
Sbjct: 1828 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD-ALPEPTVTWYKDGQPLVLAQ 1886
Query: 195 YSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPP-LVN 253
++ LR G+R L I V + C+ +N + G + T+ +Q PP N
Sbjct: 1887 RTQA-LRGGQR------LEIQEAQVSDKGLYSCKVSN--VAGEAVRTFTLTVQVPPTFEN 1937
Query: 254 LSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEAS--GEVYRTTVDYTYFSEP 311
E + + + C PA T W K ++ ++ G V R +P
Sbjct: 1938 PKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQP 1996
Query: 312 V-----SCEVTNALGSTNLSRTVDVYFGPRMTTE--PQSLLVDLGSDAIFSCAWTGNPSL 364
+C N V V PR+ + + V G + C G P
Sbjct: 1997 AQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPP 2056
Query: 365 TIVWMKRGSGV---------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLT 415
+ W+K GS + + +L LK +R DAG Y C A P G R T+
Sbjct: 2057 DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP-AGEDARLHTVN 2115
Query: 416 VNGPPII----SSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVE 471
V PP I + T + GE + C +R +PP I SW ++ L S R +
Sbjct: 2116 VLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP---IHVSWLKDGLPLPLSQRTLL- 2171
Query: 472 TISTEEGVISTLTISNIVRADFQTIYNCTAWNSFG 506
G TL IS + AD I+ C A + G
Sbjct: 2172 -----HGSGHTLRISKVQLAD-AGIFTCVAASPAG 2200
Score = 94.0 bits (232), Expect = 5e-19
Identities = 122/510 (23%), Positives = 207/510 (40%), Gaps = 85/510 (16%)
Query: 55 QDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHH 111
++ V P++L+C A P + + W+KDG R++ P G H
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLP----------GTHG 1405
Query: 112 LKILRAELQDDAVYEC---QAIQAAIRSRPARLTVLVPP----DDPV-ILGGPVISLRAG 163
L+IL A+ +D Y C + A+++ + VL+PP DDP+ +G + +
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAVKNY--HVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463
Query: 164 DPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQ 223
L L C + A P +I W + G+ + ++ + +L +G+ L I P V +
Sbjct: 1464 STLTLECESW-AVPPPTIRWYKDGQPVTPSSRLQ-VLGEGR------LLQIQPTQVSDSG 1515
Query: 224 SIVCRATNKAIPGGKETSVTIDIQHPPLVN-----------LSVEPQP---------VLE 263
+C ATN A G + + IQ PP+ LS E + ++E
Sbjct: 1516 RYLCVATNVA--GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 1573
Query: 264 DNVVTFHCSAKANPA--VTQYRWAKRGQIIKEAS----GEVYRTTVDYTYFSEPVSCEVT 317
+N +C A P +T YR + E S G V + + + SC+ +
Sbjct: 1574 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1633
Query: 318 NALGSTNLSRTVDVYFGPRMTTEPQSLL----VDLGSDAIFSCAWTGNPSLTIVWMKRGS 373
N +G L + V P + + + L+ V+ S C GNP TI W++ G
Sbjct: 1634 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL 1693
Query: 374 GV-------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQ 426
VL + + L + + DA Y+C A + G+ E+ TL V PP I+
Sbjct: 1694 PFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE-NQAGSAEKLFTLRVQVPPRIAGLD 1752
Query: 427 TQH--ALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLT 484
+ A+ + C + + P P+ + W L G E + G TL
Sbjct: 1753 LEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLG-------EEVFLLPGT-HTLQ 1803
Query: 485 ISNIVRADFQTIYNCTAWNSFGSDTEIIRL 514
+ +D +Y C A N+ G D ++++L
Sbjct: 1804 LGRARLSD-SGMYTCEALNAAGRDQKLVQL 1832
Score = 88.6 bits (218), Expect = 2e-17
Identities = 106/420 (25%), Positives = 166/420 (39%), Gaps = 52/420 (12%)
Query: 56 DQVVVSGQPVTLLCAIPEYD-GFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 114
D VVV G V L C V W+KDG L + + L P L++
Sbjct: 2224 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL-LSQSLEQGPS-------------LQL 2269
Query: 115 LRAELQDDAVYECQAI-QAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHAD 173
D Y C A+ +A R +LTV+ PP +SL G P+ L C A
Sbjct: 2270 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2329
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKA 233
P +I W + G+ + T L + R + V V + C A + A
Sbjct: 2330 GT-PQPNITWHKDGQAL-------TRLENNSRATRVLR-------VRDAGLYTCLAESPA 2374
Query: 234 IPGGKETSVTIDIQHPPLVNLSVEPQPV--LEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
G E S + +Q PP + P+ V L + CS +A PA + W + G ++
Sbjct: 2375 --GAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPA-PKITWHRDGIVL 2431
Query: 292 KEAS-------GEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSL 344
+E + G + T S SC NA GST+++ V+++ P + + P ++
Sbjct: 2432 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAV 2491
Query: 345 LVDLGSDAIFSCAWTGNPSLTIVWMK-------RGSGVVLSNEKTLTLKSVRQEDAGKYV 397
V + A+ C G P+ + W K R + E +L ++ V +DAG Y+
Sbjct: 2492 NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2551
Query: 398 CRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKE 457
C A G+ + L V PP I+ + + L + S P + W WK+
Sbjct: 2552 CLA-SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVW-WKD 2609
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/271 (28%), Positives = 114/271 (42%), Gaps = 28/271 (10%)
Query: 207 SIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNV 266
S+ L I D+ + C ATN A G + V + + PP + + VLE+
Sbjct: 654 SLPPPLQIEKVDLRDEGIYTCAATNLA--GESKREVALKVLVPPNIEPGPVNKAVLENAS 711
Query: 267 VTFHCSAKANPAVTQYRWAKRGQIIKE-------ASGEVYRTTVDYTYFSEPVSCEVTNA 319
VT C A P W K Q + G V R + C +N
Sbjct: 712 VTLECLASGVPP-PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNV 770
Query: 320 LGSTNLSRTVDVYFGPRMTTEPQ---SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV- 375
GST L + V PR+T P +LV+ + +C TG PS T++W+K G+ V
Sbjct: 771 AGSTELRYGLRVNVPPRITLPPSLPGPVLVN--TPVRLTCNATGAPSPTLMWLKDGNPVS 828
Query: 376 --------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP-IISSTQ 426
V + LTL S R D+G+Y C A V VG ++V L V+ PP I+
Sbjct: 829 PAGTPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGEDRQDVVLQVHMPPSILGEEL 887
Query: 427 TQHALHGEKGQIKCFIRSTPPPDRIAWSWKE 457
+ E ++C + PPP ++W WK+
Sbjct: 888 NVSVVANESVALECQSHAMPPP-VLSW-WKD 916
Score = 81.3 bits (199), Expect = 3e-15
Identities = 108/426 (25%), Positives = 165/426 (38%), Gaps = 46/426 (10%)
Query: 112 LKILRAELQDDAVYECQAIQAAIRS-RPARLTVLVPPDDPVILGGPVI-SLRAGDPLNLT 169
L+I + +L+D+ +Y C A A S R L VLVPP+ I GPV ++ + L
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASVTLE 715
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRA 229
C A P + W KG + T+ DG+ L I + + S C A
Sbjct: 716 CLASGVPPP-DVSWF-KGHQPVSSWMGVTVSVDGR------VLRIEQAQLSDAGSYRCVA 767
Query: 230 TNKAIPGGKETSVTIDIQHPPLVNLSVE-PQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
+N A G E + + PP + L P PVL + V C+A P+ T W K G
Sbjct: 768 SNVA--GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLKDG 824
Query: 289 QIIKEAS---------GEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTT 339
+ A G V S SC +A+G + V+ P +
Sbjct: 825 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 884
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG------SGVVLSNEKTLTLKSVRQE-- 391
E ++ V C P + W K G GV LS +K L L+ R +
Sbjct: 885 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL-LQVDRADVW 943
Query: 392 DAGKYVCRAVVPRVGAGEREVTLTVNGPPI--ISSTQTQHALHGEKGQIKCFIRSTPPPD 449
DAG Y C A + + G E+ L V P+ + + T G + C R P P
Sbjct: 944 DAGHYTCEA-LNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFP- 1001
Query: 450 RIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDT 509
+I+W L +G V + G + L + + + + Y C N G+ +
Sbjct: 1002 KISWRKDGQPLPGEGAGLQHVSAV----GRLLYLGQAQLAQ---EGTYTCECSNVVGNSS 1054
Query: 510 EIIRLK 515
+ ++L+
Sbjct: 1055 QDLQLE 1060
Score = 79.0 bits (193), Expect = 2e-14
Identities = 107/423 (25%), Positives = 161/423 (38%), Gaps = 57/423 (13%)
Query: 109 EHHLKILRAELQDDAVYECQAIQAAIRSRPAR-LTVLVPPDDPVILGGPV-ISLRAGDPL 166
E L+I QD Y C A +A R R L VL PP I P ++L A P
Sbjct: 2534 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP---AIAPSPSNLTLTAHTPA 2590
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVST--LFISPGDVENGQS 224
L C A + P ++W + G+ ++ L+ G + S L +PG ++ Q
Sbjct: 2591 LLPCEASGS-PKPLVVWWKDGQKLDFR------LQQGAYRLLPSNALLLTAPGPQDSAQ- 2642
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
C +N+ + VT+ + PP + V V C + PA T W
Sbjct: 2643 FECVVSNEVGEAHRLYQVTVHV--PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSW 2699
Query: 285 AKRGQIIKEASGEVYRTTVD--------YTYFSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
+K G + A G YR + + +C N+ G + + V P
Sbjct: 2700 SKAGAQLG-ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2758
Query: 337 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK------TLTLKSVRQ 390
+ P + + + C +G P TI W K G V L +
Sbjct: 2759 VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASP 2818
Query: 391 EDAGKYVCRAVVPRVGAGEREVTLTVNGPPII-------SSTQTQHALHGEKGQIKCFIR 443
EDAG Y+C A G+ + L V PP+I S+T+ HA + C R
Sbjct: 2819 EDAGNYLCIA-KNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAF------LPCKAR 2871
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
+P P+ I W K+ SG G++T++ L + N+ D T Y CTA N
Sbjct: 2872 GSPEPN-ITWD-KDGQPVSGAEGKFTIQP-------SGELLVKNLEGQDAGT-YTCTAEN 2921
Query: 504 SFG 506
+ G
Sbjct: 2922 AVG 2924
Score = 76.6 bits (187), Expect = 8e-14
Identities = 115/459 (25%), Positives = 175/459 (38%), Gaps = 63/459 (13%)
Query: 32 GYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALG 88
G A+D R++ S + + V+ V LLC +P + + W KDG L
Sbjct: 296 GQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN--ITWFKDGALLP 353
Query: 89 VGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQA-AIRSRPARLTVLVPP 147
+ + G L++ RA+ D VY C+A A + RL V VPP
Sbjct: 354 TSTKVV----------YTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP 403
Query: 148 DDPVILGGP-VISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRE 206
G P V+ AG P+ L C A P+ ++ W +G + + S+ L DG
Sbjct: 404 TIEGAGGRPYVVKAVAGRPVALECVA-RGHPSPTLSWHHEGLPVAESNESR-LETDG--- 458
Query: 207 SIVSTLFI-SPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPP--LVNLSVEPQPVLE 263
S L + SPG+ +G C A++ A G ++++Q PP LV + +
Sbjct: 459 ---SVLRLESPGEASSG-LYSCVASSPA--GEAVLQYSVEVQVPPQLLVAEGLGQVTTIV 512
Query: 264 DNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG---EVYRTTVDYTY----FSEPVSCEV 316
+ C A +P T +W + G+ +E +G TT+ + S +C+
Sbjct: 513 GQPLELPCQASGSPVPT-IQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 571
Query: 317 TNALGSTNLSRTVDVY--FGPRMTTEP---------QSLLVDLGSDAIFSCAWTGNPSLT 365
TN G+ V V+ + P + P D W +P
Sbjct: 572 TNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPP 631
Query: 366 IV--WMKRGS--------GVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLT 415
+V W GS V S L ++ V D G Y C A G +REV L
Sbjct: 632 LVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTC-AATNLAGESKREVALK 690
Query: 416 VNGPPIISSTQTQHA-LHGEKGQIKCFIRSTPPPDRIAW 453
V PP I A L ++C PPPD ++W
Sbjct: 691 VLVPPNIEPGPVNKAVLENASVTLECLASGVPPPD-VSW 728
Score = 70.5 bits (171), Expect = 6e-12
Identities = 122/526 (23%), Positives = 195/526 (37%), Gaps = 93/526 (17%)
Query: 59 VVSGQPVTLLCAIPEYDGFVL-WIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHL-KILR 116
V+ GQ L+C + + L W KDG L G +H+S + L ++L+
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD-----------AHHISPDGVLLQVLQ 1314
Query: 117 AELQDDAVYECQAIQAA-IRSRPARLTVLVPPDDPVILGGPV------ISLRAGDPLNLT 169
A L Y C A A +++ +L+VL+ P ILGG +++ +P++L
Sbjct: 1315 ANLSSAGHYSCIAANAVGEKTKHFQLSVLLAP---TILGGAEDSADEEVTVTVNNPISLI 1371
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRA 229
C A A P+ +I W++ G + + L L I E+ C
Sbjct: 1372 CEA-LAFPSPNITWMKDGAPFEASRNIQLLPG-------THGLQILNAQKEDAGQYTCVV 1423
Query: 230 TNKAIPGGKETSVTIDI-----QHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
TN+ K V + I + PL + V+ ++ +T C + A P T RW
Sbjct: 1424 TNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT-IRW 1482
Query: 285 AKRGQIIKEAS-----GEVYRTTVDYTYFSEP--VSCEVTNALGSTNLSRTVDVYFGPRM 337
K GQ + +S GE + T S+ C TN G + V + P
Sbjct: 1483 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMF 1542
Query: 338 ----------------------TTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
TE + ++ + + A C P + W + +
Sbjct: 1543 QKVGDFSAAFEILSREEEARGGVTEYREIVEN--NPAYLYCDTNAIPPPDLTWYREDQPL 1600
Query: 376 -------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQ 428
VL + L + VR E+AG+Y C+A VG L V PP+I T+
Sbjct: 1601 SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA-SNEVGEDWLHYELLVLTPPVILG-DTE 1658
Query: 429 HALH------GEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVIST 482
+ ++C P P SW +N L S R V E+G +
Sbjct: 1659 ELVEEVTVNASSTVSLQCPALGNPVP---TISWLQNGLPFSPSPRLQV----LEDGQVLQ 1711
Query: 483 LTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLE 528
++ + + A Y C A N GS ++ L+ Q +G LE
Sbjct: 1712 VSTAEVADA---ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLE 1754
Score = 70.1 bits (170), Expect = 7e-12
Identities = 123/504 (24%), Positives = 188/504 (37%), Gaps = 90/504 (17%)
Query: 51 SQQPQDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
S QP + + G P+ LLC P+ + + W KDG AL + S + L V
Sbjct: 2308 SGQPTELSLTPGAPMELLCDAQGTPQPN--ITWHKDGQALTRLENNSRATRVLRV----- 2360
Query: 108 GEHHLKILRAELQDDAVYECQAIQ-AAIRSRPARLTVLVPPDDPVILG--GP--VISLRA 162
+D +Y C A A + R+ V PP+ I+G GP V+ L
Sbjct: 2361 ------------RDAGLYTCLAESPAGAIEKSFRVRVQAPPN---IVGPRGPRFVVGLAP 2405
Query: 163 GDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
G L L C + A+PA I W R G V+ +++ R G+ + + GD
Sbjct: 2406 GQ-LVLECSVE-AEPAPKITWHRDGIVLQEDAHTQFPER-GRFLQLQALSTADSGDYS-- 2460
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQH-------PPLVNLSVEPQPVLEDNVVTFHCSAKA 275
C A N A G + ++I PP VN+SV +L C A
Sbjct: 2461 ----CTARNAA--GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLP-------CQADG 2507
Query: 276 NPAVTQYRWAK----------RGQIIKEASGEVYRTTV-DYTYFSEPVSCEVTNALGSTN 324
PA W K R +I+ E S + D ++ C +N+ GS
Sbjct: 2508 VPAPL-VSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL----CLASNSAGSDR 2562
Query: 325 LSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG---------SGV 375
R + V P + P +L + + A+ C +G+P +VW K G
Sbjct: 2563 QGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY 2622
Query: 376 VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEK 435
L L L + +D+ ++ C V VG R +TV+ PP I+ QT +
Sbjct: 2623 RLLPSNALLLTAPGPQDSAQFEC-VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMA 2681
Query: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQT 495
+ + P ++WS L + SG + + E G +
Sbjct: 2682 PVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR-------- 2733
Query: 496 IYNCTAWNSFGSDTEIIRLKEQGS 519
Y C+A NS G + + L Q S
Sbjct: 2734 -YTCSARNSAGVAHKHVFLTVQAS 2756
Score = 67.4 bits (163), Expect = 5e-11
Identities = 93/349 (26%), Positives = 136/349 (38%), Gaps = 44/349 (12%)
Query: 107 SGEHHLKILRAELQDDAVYECQAIQAAIRSRP-ARLTVLVPPDDPVILGGPVISLRAGDP 165
SGE L + E QD Y C A A R+R LT+LV P + G SLR GD
Sbjct: 2899 SGE--LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR--SLRLGDR 2954
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
L L C A P I W + + DG STL + E+ +
Sbjct: 2955 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQ----DGG-----STLQRAAVSREDSGTY 3004
Query: 226 VCRATNKAIPGGKETSVT-IDIQHPPLVN---LSVEPQPVLEDNVVTFHCSAKANPAVTQ 281
VC A N+ G+ +V+ + ++ P++ S +PV + C + +P V
Sbjct: 3005 VCWAENRV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPV--GGSIQLDCVVRGDP-VPD 3058
Query: 282 YRWAKRG---------QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVY 332
W K G ++ S ++RT D + C N +G + +
Sbjct: 3059 IHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDD---AGRYQCLAENEMGVAKKVVILVLQ 3115
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSN------EKTLTLK 386
P EPQ + V G D C TG P+ TI W++ G + S + +L L+
Sbjct: 3116 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE 3175
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEK 435
+V DAG Y C A +G+ L V G P S ++G K
Sbjct: 3176 NVETGDAGTYDCVA-HNLLGSATARAFLVVRGEPQGSWGSMTGVINGRK 3223
Score = 66.6 bits (161), Expect = 8e-11
Identities = 107/455 (23%), Positives = 174/455 (38%), Gaps = 64/455 (14%)
Query: 59 VVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRD--LSSYPQYLVVGNHLSGEHHLKIL 115
V+ PV L C A ++W+KDG + L +P G L +
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP----------GGRVLTLA 847
Query: 116 RAELQDDAVYECQAIQAAIRSRP-ARLTVLVPPDDPVILGGPV-ISLRAGDPLNLTCHAD 173
A D Y C A+ A R L V +PP ILG + +S+ A + + L C +
Sbjct: 848 SARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQS- 903
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLF-ISPGDVENGQSIVCRATNK 232
+A P + W + G + R G S L + DV + C A N+
Sbjct: 904 HAMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQ 955
Query: 233 AIPGGKETSVTIDIQHPPLVNL-SVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
A G E +++ P+ L V E + + C + P + W K GQ +
Sbjct: 956 A--GRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP-FPKISWRKDGQPL 1012
Query: 292 K-EASGEVYRTTVDYTYF--------SEPVSCEVTNALGSTNLSRTVDVYFGPRMT---T 339
E +G + + V + +CE +N +G+++ ++V+ P++
Sbjct: 1013 PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE 1072
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGS------GVVLSNE-KTLTLKSVRQED 392
P + V A C TG P T+ W + G G+ L N+ ++L ++ +
Sbjct: 1073 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAH 1132
Query: 393 AGKYVCRAVVPRVGAGEREVTLTVNGPPIISS-----TQTQHALHGEKGQIKCFIRSTPP 447
G+Y C A G ER+ L+V PP + T ALH + C PP
Sbjct: 1133 TGRYSCVA-ENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL-TLLCEAMGIPP 1190
Query: 448 PDRIAWSWKENVLESG-----TSGRYTVETISTEE 477
P I W E + G +G + ++ T+E
Sbjct: 1191 P-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQE 1224
Score = 65.9 bits (159), Expect = 1e-10
Identities = 114/494 (23%), Positives = 178/494 (36%), Gaps = 71/494 (14%)
Query: 60 VSGQPVTLLCAIPEYDGF----VLWIKDGLALGVGRDLSSYPQYL---VVGNH--LSGEH 110
++GQ +TL C + +GF ++W+KD +GV + Y L VG H L
Sbjct: 109 MAGQSLTLEC---DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 165
Query: 111 HLKILRAELQDDAVYECQAIQAAIRSRP--ARLT---------VLVPPDDPVILGG---- 155
L R + QA +A P A L PP P +LG
Sbjct: 166 SLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQ 225
Query: 156 PVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFIS 215
V+ L AG + L C P + W + + + + DG+ L I+
Sbjct: 226 EVLGL-AGADVELQCWTSGV-PTPQVEWTKDRQPVLPGGPHLQVQEDGQ------VLRIT 277
Query: 216 PGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPV--LEDNVVTFHCSA 273
V + C A + A G + + + PP + S E V +ED++V C A
Sbjct: 278 GSHVGDEGRYQCVAFSPA--GQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335
Query: 274 KANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVS-------CEVTNALGSTNLS 326
+ P W K G ++ ++ VY S C+ +NA+G+ +
Sbjct: 336 RGVPT-PNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 394
Query: 327 RTVDVYFGPRMTT---EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE--- 380
+DVY P + P + G C G+PS T+ W G V SNE
Sbjct: 395 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL 454
Query: 381 ----KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP---IISSTQTQHALHG 433
L L+S + +G Y C A P G + ++ V PP + + G
Sbjct: 455 ETDGSVLRLESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVG 513
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADF 493
+ ++ C +P P W +N GR E + T + V D
Sbjct: 514 QPLELPCQASGSPVP---TIQWLQN-------GRPAEELAGVQVASQGTTLHIDHVELDH 563
Query: 494 QTIYNCTAWNSFGS 507
++ C A N G+
Sbjct: 564 SGLFACQATNEAGT 577
Score = 63.5 bits (153), Expect = 7e-10
Identities = 106/495 (21%), Positives = 179/495 (36%), Gaps = 83/495 (16%)
Query: 64 PVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDD 122
P+TLLC A+ + W + + G D YL+ G + LK+ + + QD
Sbjct: 1178 PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDT-----YLLAGGWM-----LKMTQTQEQDS 1227
Query: 123 AVYECQAI-QAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASI 181
+Y C A +A R + VLVPP VI + G +L C+ P +
Sbjct: 1228 GLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKL 1286
Query: 182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETS 241
W + G + + + DG ++ S G C A N G K
Sbjct: 1287 TWFKDGRPLARGD-AHHISPDGVLLQVLQANLSSAGHYS------CIAANAV--GEKTKH 1337
Query: 242 VTIDIQHPPLV-----NLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG 296
+ + P + + + E V +N ++ C A A P+ W K G EAS
Sbjct: 1338 FQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPS-PNITWMKDGAPF-EASR 1395
Query: 297 EVYRTTVDY--------TYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEP------- 341
+ + + +C VTN LG + V+V P ++ +
Sbjct: 1396 NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGV 1455
Query: 342 QSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV-------VLSNEKTLTLKSVRQEDAG 394
+ + + S C P TI W K G V VL + L ++ + D+G
Sbjct: 1456 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSG 1515
Query: 395 KYVCRAVVPRVGAGEREVTLTVNGPPIISS---------------------TQTQHALHG 433
+Y+C A G +++ + + PP+ T+ + +
Sbjct: 1516 RYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVEN 1574
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADF 493
+ C + PPPD + W ++ L +G + +S +G + +VRA+
Sbjct: 1575 NPAYLYCDTNAIPPPD-LTWYREDQPLSAG-------DEVSVLQG--GRVLQIPLVRAEN 1624
Query: 494 QTIYNCTAWNSFGSD 508
Y+C A N G D
Sbjct: 1625 AGRYSCKASNEVGED 1639
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/109 (31%), Positives = 45/109 (41%), Gaps = 13/109 (11%)
Query: 356 CAWTGNPSLTIVWMKRGS--------GVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGA 407
C G P + W K S GV + E +L L SV D+G Y C+A VG+
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQA-TNEVGS 82
Query: 408 GEREVTLTVNGPPIISSTQTQHALHGEKGQ---IKCFIRSTPPPDRIAW 453
R L V PP I + + G GQ ++C P P+ I W
Sbjct: 83 TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE-IVW 130
Score = 31.2 bits (69), Expect = 3.8
Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 2/59 (3%)
Query: 314 CEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVD--LGSDAIFSCAWTGNPSLTIVWMK 370
C+ TN +GST+ + VY P + + + V G C G P IVW+K
Sbjct: 74 CQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLK 132
Score = 30.8 bits (68), Expect = 5.0
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 12/81 (14%)
Query: 50 FSQQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSG 108
F +PQD V SG V L C A E + W++ G L R L + P
Sbjct: 3120 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLP----------- 3168
Query: 109 EHHLKILRAELQDDAVYECQA 129
+ L + E D Y+C A
Sbjct: 3169 DGSLWLENVETGDAGTYDCVA 3189
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 99.4 bits (246), Expect = 1e-20
Identities = 123/455 (27%), Positives = 183/455 (40%), Gaps = 58/455 (12%)
Query: 78 VLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSR 137
V W KD AL +G ++ P G H L++ RA L D +Y C+A+ AA R +
Sbjct: 2969 VTWYKDSQALSLGEEVFLLP----------GTHTLQLGRARLSDSGMYTCEALNAAGRDQ 3018
Query: 138 P-ARLTVLVPPDDPVILGGP--VISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGAT 194
+L+VLVPP GP + +R GD L+C D A P ++ W + G+ + A
Sbjct: 3019 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD-ALPEPTVTWYKDGQPLVLAQ 3077
Query: 195 YSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPP-LVN 253
++ LR G+R L I V + C+ +N + G + T+ +Q PP N
Sbjct: 3078 RTQA-LRGGQR------LEIQEAQVSDKGLYSCKVSN--VAGEAVRTFTLTVQVPPTFEN 3128
Query: 254 LSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEAS--GEVYRTTVDYTYFSEP 311
E + + + C PA T W K ++ ++ G V R +P
Sbjct: 3129 PKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQP 3187
Query: 312 V-----SCEVTNALGSTNLSRTVDVYFGPRMTTE--PQSLLVDLGSDAIFSCAWTGNPSL 364
+C N V V PR+ + + V G + C G P
Sbjct: 3188 AQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPP 3247
Query: 365 TIVWMKRGSGV---------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLT 415
+ W+K GS + + +L LK +R DAG Y C A P G R T+
Sbjct: 3248 DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP-AGEDARLHTVN 3306
Query: 416 VNGPPII----SSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVE 471
V PP I + T + GE + C +R +PP I SW ++ L S R +
Sbjct: 3307 VLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP---IHVSWLKDGLPLPLSQRTLL- 3362
Query: 472 TISTEEGVISTLTISNIVRADFQTIYNCTAWNSFG 506
G TL IS + AD I+ C A + G
Sbjct: 3363 -----HGSGHTLRISKVQLAD-AGIFTCVAASPAG 3391
Score = 98.6 bits (244), Expect = 2e-20
Identities = 100/405 (24%), Positives = 170/405 (41%), Gaps = 41/405 (10%)
Query: 63 QPVTLLCAIPEYDGFVLWIKDGLA-LGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQD 121
QP+ + C++ F L ++ G A LG R SG +ILRA +
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQE-----------SGNSSWEILRASKAE 490
Query: 122 DAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASI 181
+ YEC A+ A R A+ ++V P ++ P +++ G+ L+C P ++
Sbjct: 491 EGTYECTAVSRAGTGR-AKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAP-YNL 548
Query: 182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETS 241
W+R V+ +T L D +L IS +G C A+N G S
Sbjct: 549 TWVRDWRVLPASTGRVAQLAD-------LSLEISGIIPTDGGRYQCVASN--ANGVTRAS 599
Query: 242 VTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG---EV 298
V + ++ P V++ Q + V CSA P W++ Q ++E S +
Sbjct: 600 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP-TPHISWSRESQALQEDSRIHVDA 658
Query: 299 YRTTVDYTYFSEPV---SCEVTNALGSTNLSRTVDVYF--GPRMTTEPQSLLVDLGSDAI 353
T + E SC+ TN +G+ TV +Y+ P ++ +LV +G +A+
Sbjct: 659 QGTLIIQGVAPEDAGNYSCQATNEVGTD--QETVTLYYTDPPSVSAVNAVVLVAVGEEAV 716
Query: 354 FSCAWTGNPSLTIVWMKRGSGVVLSNEKT----LTLKSVRQEDAGKYVCRAVVPRVGAGE 409
C +G P ++W + G ++L+ E + L + + ++ DAG Y CRA V +G
Sbjct: 717 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA-VNELGDAS 775
Query: 410 REVTLTVNGPPIISSTQTQHALH-GEKGQIKCFIRSTPPPDRIAW 453
E+ L V P ++ + G + C PPP + W
Sbjct: 776 AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVTW 819
Score = 94.0 bits (232), Expect = 5e-19
Identities = 122/510 (23%), Positives = 207/510 (40%), Gaps = 85/510 (16%)
Query: 55 QDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHH 111
++ V P++L+C A P + + W+KDG R++ P G H
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLP----------GTHG 2596
Query: 112 LKILRAELQDDAVYEC---QAIQAAIRSRPARLTVLVPP----DDPV-ILGGPVISLRAG 163
L+IL A+ +D Y C + A+++ + VL+PP DDP+ +G + +
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAVKNY--HVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654
Query: 164 DPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQ 223
L L C + A P +I W + G+ + ++ + +L +G+ L I P V +
Sbjct: 2655 STLTLECESW-AVPPPTIRWYKDGQPVTPSSRLQ-VLGEGR------LLQIQPTQVSDSG 2706
Query: 224 SIVCRATNKAIPGGKETSVTIDIQHPPLVN-----------LSVEPQP---------VLE 263
+C ATN A G + + IQ PP+ LS E + ++E
Sbjct: 2707 RYLCVATNVA--GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 2764
Query: 264 DNVVTFHCSAKANPA--VTQYRWAKRGQIIKEAS----GEVYRTTVDYTYFSEPVSCEVT 317
+N +C A P +T YR + E S G V + + + SC+ +
Sbjct: 2765 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 2824
Query: 318 NALGSTNLSRTVDVYFGPRMTTEPQSLL----VDLGSDAIFSCAWTGNPSLTIVWMKRGS 373
N +G L + V P + + + L+ V+ S C GNP TI W++ G
Sbjct: 2825 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL 2884
Query: 374 GV-------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQ 426
VL + + L + + DA Y+C A + G+ E+ TL V PP I+
Sbjct: 2885 PFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE-NQAGSAEKLFTLRVQVPPRIAGLD 2943
Query: 427 TQH--ALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLT 484
+ A+ + C + + P P+ + W L G E + G TL
Sbjct: 2944 LEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLG-------EEVFLLPGT-HTLQ 2994
Query: 485 ISNIVRADFQTIYNCTAWNSFGSDTEIIRL 514
+ +D +Y C A N+ G D ++++L
Sbjct: 2995 LGRARLSD-SGMYTCEALNAAGRDQKLVQL 3023
Score = 88.6 bits (218), Expect = 2e-17
Identities = 106/420 (25%), Positives = 166/420 (39%), Gaps = 52/420 (12%)
Query: 56 DQVVVSGQPVTLLCAIPEYD-GFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 114
D VVV G V L C V W+KDG L + + L P L++
Sbjct: 3415 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL-LSQSLEQGPS-------------LQL 3460
Query: 115 LRAELQDDAVYECQAI-QAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHAD 173
D Y C A+ +A R +LTV+ PP +SL G P+ L C A
Sbjct: 3461 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 3520
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKA 233
P +I W + G+ + T L + R + V V + C A + A
Sbjct: 3521 GT-PQPNITWHKDGQAL-------TRLENNSRATRVLR-------VRDAGLYTCLAESPA 3565
Query: 234 IPGGKETSVTIDIQHPPLVNLSVEPQPV--LEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
G E S + +Q PP + P+ V L + CS +A PA + W + G ++
Sbjct: 3566 --GAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPA-PKITWHRDGIVL 3622
Query: 292 KEAS-------GEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSL 344
+E + G + T S SC NA GST+++ V+++ P + + P ++
Sbjct: 3623 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAV 3682
Query: 345 LVDLGSDAIFSCAWTGNPSLTIVWMK-------RGSGVVLSNEKTLTLKSVRQEDAGKYV 397
V + A+ C G P+ + W K R + E +L ++ V +DAG Y+
Sbjct: 3683 NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 3742
Query: 398 CRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKE 457
C A G+ + L V PP I+ + + L + S P + W WK+
Sbjct: 3743 CLA-SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVW-WKD 3800
Score = 85.5 bits (210), Expect = 2e-16
Identities = 114/469 (24%), Positives = 176/469 (37%), Gaps = 84/469 (17%)
Query: 59 VVSGQPVTLLCAI------PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHL 112
V+ GQPV+L C + PE W+KDG L G S + + L
Sbjct: 896 VLEGQPVSLPCIVLAGRPLPERH----WLKDGRPLPPGSRHS-----------IRADGSL 940
Query: 113 KILRAELQDDAVYECQAIQAA-IRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCH 171
+ RA + Y C A A + R L V VPP + + G P +L C
Sbjct: 941 HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN--EGVPASLPCV 998
Query: 172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATN 231
A PA +I W ++ + + ++G TL I+ ++ + VC ATN
Sbjct: 999 ASGV-PAPTITWTKETNALTSRGPHYNVSKEG-------TLLIAQPSAQDAGAYVCTATN 1050
Query: 232 KAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
+E ++++ A+++Y W + G +
Sbjct: 1051 TVGFSSQEMRLSVN------------------------------RLALSKYVWEEYGLL- 1079
Query: 292 KEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSD 351
SG + V S C +N GS + + V P++ P+ L V +G
Sbjct: 1080 --PSGSLRLAQVQVGD-SGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEA 1136
Query: 352 AIFSCAWTGNPSLTIVWMKRGSGVVLSN---EKTLTLKSVRQEDAGKYVCRAVVPRVGAG 408
+C GNP + W K GVVL + ++ ++R DAG+Y C A G
Sbjct: 1137 LDLNCVAEGNPEPQLSWSK--DGVVLQGRGPQGSVHFAAIRTSDAGRYRCEA-SNSAGVD 1193
Query: 409 EREVTLTVNGPPIISSTQTQHALH---GEKGQIKCFIRSTPPPDRIAWSWKENVLESGTS 465
EV L V PP + +T L GE + C R TP P +W++
Sbjct: 1194 AWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQ---VTWRKGPSSEPLH 1250
Query: 466 GRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRL 514
G+ V + EEG + ++S D Y C A N GS + +L
Sbjct: 1251 GQPGVAVL--EEGSLFLASVSPADSGD----YECQATNEVGSTSRRAKL 1293
Score = 83.2 bits (204), Expect = 9e-16
Identities = 117/484 (24%), Positives = 182/484 (37%), Gaps = 64/484 (13%)
Query: 60 VSGQPVTLLCAIPEYDGF----VLWIKDGLALGVGRDLSSYPQYL---VVGNH--LSGEH 110
++GQ +TL C + +GF ++W+KD +GV + Y L VG H L
Sbjct: 1313 MAGQSLTLEC---DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 1369
Query: 111 HLKILRAELQDDAVYECQAI-QAAIRSRPARLTVLVPPDDPVILGG----PVISLRAGDP 165
L R + D +Y C+A QA R L VL PP +LG V+ L AG
Sbjct: 1370 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS---VLGAGAAQEVLGL-AGAD 1425
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
+ L C P + W + + + + DG+ L I+ V +
Sbjct: 1426 VELQCWTSGV-PTPQVEWTKDRQPVLPGGPHLQVQEDGQ------VLRITGSHVGDEGRY 1478
Query: 226 VCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPV--LEDNVVTFHCSAKANPAVTQYR 283
C A + A G + + + PP + S E V +ED++V C A+ P
Sbjct: 1479 QCVAFSPA--GQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPT-PNIT 1535
Query: 284 WAKRGQIIKEASGEVYRTTVDYTYFSEPVS-------CEVTNALGSTNLSRTVDVYFGPR 336
W K G ++ ++ VY S C+ +NA+G+ + +DVY P
Sbjct: 1536 WFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 1595
Query: 337 MTT---EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE-------KTLTLK 386
+ P + G C G+PS T+ W G V SNE L L+
Sbjct: 1596 IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLE 1655
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP---IISSTQTQHALHGEKGQIKCFIR 443
S + +G Y C A P G + ++ V PP + + G+ ++ C
Sbjct: 1656 SPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS 1714
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
+P P W +N GR E + T + V D ++ C A N
Sbjct: 1715 GSPVP---TIQWLQN-------GRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN 1764
Query: 504 SFGS 507
G+
Sbjct: 1765 EAGT 1768
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/271 (28%), Positives = 114/271 (42%), Gaps = 28/271 (10%)
Query: 207 SIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNV 266
S+ L I D+ + C ATN A G + V + + PP + + VLE+
Sbjct: 1845 SLPPPLQIEKVDLRDEGIYTCAATNLA--GESKREVALKVLVPPNIEPGPVNKAVLENAS 1902
Query: 267 VTFHCSAKANPAVTQYRWAKRGQIIKE-------ASGEVYRTTVDYTYFSEPVSCEVTNA 319
VT C A P W K Q + G V R + C +N
Sbjct: 1903 VTLECLASGVPP-PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNV 1961
Query: 320 LGSTNLSRTVDVYFGPRMTTEPQ---SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV- 375
GST L + V PR+T P +LV+ + +C TG PS T++W+K G+ V
Sbjct: 1962 AGSTELRYGLRVNVPPRITLPPSLPGPVLVN--TPVRLTCNATGAPSPTLMWLKDGNPVS 2019
Query: 376 --------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP-IISSTQ 426
V + LTL S R D+G+Y C A V VG ++V L V+ PP I+
Sbjct: 2020 PAGTPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGEDRQDVVLQVHMPPSILGEEL 2078
Query: 427 TQHALHGEKGQIKCFIRSTPPPDRIAWSWKE 457
+ E ++C + PPP ++W WK+
Sbjct: 2079 NVSVVANESVALECQSHAMPPP-VLSW-WKD 2107
Score = 80.9 bits (198), Expect = 4e-15
Identities = 108/426 (25%), Positives = 165/426 (38%), Gaps = 46/426 (10%)
Query: 112 LKILRAELQDDAVYECQAIQAAIRS-RPARLTVLVPPDDPVILGGPVI-SLRAGDPLNLT 169
L+I + +L+D+ +Y C A A S R L VLVPP+ I GPV ++ + L
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASVTLE 1906
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRA 229
C A P + W KG + T+ DG+ L I + + S C A
Sbjct: 1907 CLASGVPPP-DVSWF-KGHQPVSSWMGVTVSVDGR------VLRIEQAQLSDAGSYRCVA 1958
Query: 230 TNKAIPGGKETSVTIDIQHPPLVNLSVE-PQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
+N A G E + + PP + L P PVL + V C+A P+ T W K G
Sbjct: 1959 SNVA--GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLKDG 2015
Query: 289 QIIKEAS---------GEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTT 339
+ A G V S SC +A+G + V+ P +
Sbjct: 2016 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 2075
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG------SGVVLSNEKTLTLKSVRQE-- 391
E ++ V C P + W K G GV LS +K L L+ R +
Sbjct: 2076 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL-LQVDRADVW 2134
Query: 392 DAGKYVCRAVVPRVGAGEREVTLTVNGPPI--ISSTQTQHALHGEKGQIKCFIRSTPPPD 449
DAG Y C A + + G E+ L V P+ + + T G + C R P P
Sbjct: 2135 DAGHYTCEA-LNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFP- 2192
Query: 450 RIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDT 509
+I+W L +G V + G + L + + + + Y C N G+ +
Sbjct: 2193 KISWRKDGQPLPGEGAGLQHVSAV----GRLLYLGQAQLAQ---EGTYTCECSNVVGNSS 2245
Query: 510 EIIRLK 515
+ ++L+
Sbjct: 2246 QDLQLE 2251
Score = 79.3 bits (194), Expect = 1e-14
Identities = 102/416 (24%), Positives = 159/416 (38%), Gaps = 42/416 (10%)
Query: 121 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 180
D Y+C A A +R A + +LV V + G + ++C A + P
Sbjct: 581 DGGRYQCVASNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPH 638
Query: 181 IIWLRKGEVINGATYSKTLLRDGK-RESIVSTLFISPGDVENGQSIVCRATNKAIPGGKE 239
I W R+ S+ L D + TL I E+ + C+ATN+ G +
Sbjct: 639 ISWSRE---------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV--GTDQ 687
Query: 240 TSVTIDIQHPPLVNL--SVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGE 297
+VT+ PP V+ +V V E+ V+ S P V YR + E S
Sbjct: 688 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS 747
Query: 298 -VYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSC 356
R + +C N LG + + V P++T P+ + V+LG A+ +C
Sbjct: 748 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 807
Query: 357 AWTGNPSLTIVWMK-------------RGSGVVLSNEKTLTLKSVRQEDAGKYVCRA--V 401
TG P T+ W + RGS + L +SV ED YVC A V
Sbjct: 808 RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV 867
Query: 402 VPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLE 461
+V A R + P I SS T L G+ + C + + P W L
Sbjct: 868 FGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 927
Query: 462 SGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQ 517
G+ R+++ +L + ++ + Y+C A N+ GS + L Q
Sbjct: 928 PGS--RHSIR-------ADGSLHLDRALQ-EHAGRYSCVATNTAGSQHRDVELVVQ 973
Score = 79.0 bits (193), Expect = 2e-14
Identities = 107/423 (25%), Positives = 161/423 (38%), Gaps = 57/423 (13%)
Query: 109 EHHLKILRAELQDDAVYECQAIQAAIRSRPAR-LTVLVPPDDPVILGGPV-ISLRAGDPL 166
E L+I QD Y C A +A R R L VL PP I P ++L A P
Sbjct: 3725 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP---AIAPSPSNLTLTAHTPA 3781
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVST--LFISPGDVENGQS 224
L C A + P ++W + G+ ++ L+ G + S L +PG ++ Q
Sbjct: 3782 LLPCEASGS-PKPLVVWWKDGQKLDFR------LQQGAYRLLPSNALLLTAPGPQDSAQ- 3833
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
C +N+ + VT+ + PP + V V C + PA T W
Sbjct: 3834 FECVVSNEVGEAHRLYQVTVHV--PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSW 3890
Query: 285 AKRGQIIKEASGEVYRTTVD--------YTYFSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
+K G + A G YR + + +C N+ G + + V P
Sbjct: 3891 SKAGAQLG-ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 3949
Query: 337 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK------TLTLKSVRQ 390
+ P + + + C +G P TI W K G V L +
Sbjct: 3950 VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASP 4009
Query: 391 EDAGKYVCRAVVPRVGAGEREVTLTVNGPPII-------SSTQTQHALHGEKGQIKCFIR 443
EDAG Y+C A G+ + L V PP+I S+T+ HA + C R
Sbjct: 4010 EDAGNYLCIA-KNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAF------LPCKAR 4062
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
+P P+ I W K+ SG G++T++ L + N+ D T Y CTA N
Sbjct: 4063 GSPEPN-ITWD-KDGQPVSGAEGKFTIQP-------SGELLVKNLEGQDAGT-YTCTAEN 4112
Query: 504 SFG 506
+ G
Sbjct: 4113 AVG 4115
Score = 72.8 bits (177), Expect = 1e-12
Identities = 102/388 (26%), Positives = 149/388 (38%), Gaps = 59/388 (15%)
Query: 58 VVVSGQPVTLLCAIPEYDGF----VLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLK 113
+V G+ L+C E G V+W + GL + + + SS SG+ L+
Sbjct: 708 LVAVGEEAVLVC---EASGVPPPRVIWYRGGLEMILAPEGSS-----------SGK--LR 751
Query: 114 ILRAELQDDAVYECQA----------IQAAIRSRPARLTVLVPPDDPVILGGPVISLRAG 163
I A+ +D Y C+A IQ A+ P +LT L P D V LG +
Sbjct: 752 IPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-QLTEL-PRDVTVELGRSAL----- 804
Query: 164 DPLNLTCHADNAKPAASIIWLR-KGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
L C A +P ++ W R G+ + + R + +S V LF E+
Sbjct: 805 ----LACRA-TGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV--LFFESVAPEDQ 857
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQY 282
VC A N E + + PP + S VLE V+ C A + +
Sbjct: 858 APYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER 917
Query: 283 RWAKRGQIIKEASGEVYRTTVDYTY------FSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
W K G+ + S R + SC TN GS + + V PR
Sbjct: 918 HWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR 977
Query: 337 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK-------RGSGVVLSNEKTLTLKSVR 389
+ + + G A C +G P+ TI W K RG +S E TL +
Sbjct: 978 IHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 1037
Query: 390 QEDAGKYVCRAVVPRVGAGEREVTLTVN 417
+DAG YVC A VG +E+ L+VN
Sbjct: 1038 AQDAGAYVCTA-TNTVGFSSQEMRLSVN 1064
Score = 70.5 bits (171), Expect = 6e-12
Identities = 122/526 (23%), Positives = 195/526 (37%), Gaps = 93/526 (17%)
Query: 59 VVSGQPVTLLCAIPEYDGFVL-WIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHL-KILR 116
V+ GQ L+C + + L W KDG L G +H+S + L ++L+
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD-----------AHHISPDGVLLQVLQ 2505
Query: 117 AELQDDAVYECQAIQAA-IRSRPARLTVLVPPDDPVILGGPV------ISLRAGDPLNLT 169
A L Y C A A +++ +L+VL+ P ILGG +++ +P++L
Sbjct: 2506 ANLSSAGHYSCIAANAVGEKTKHFQLSVLLAP---TILGGAEDSADEEVTVTVNNPISLI 2562
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRA 229
C A A P+ +I W++ G + + L L I E+ C
Sbjct: 2563 CEA-LAFPSPNITWMKDGAPFEASRNIQLLPG-------THGLQILNAQKEDAGQYTCVV 2614
Query: 230 TNKAIPGGKETSVTIDI-----QHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
TN+ K V + I + PL + V+ ++ +T C + A P T RW
Sbjct: 2615 TNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT-IRW 2673
Query: 285 AKRGQIIKEAS-----GEVYRTTVDYTYFSEP--VSCEVTNALGSTNLSRTVDVYFGPRM 337
K GQ + +S GE + T S+ C TN G + V + P
Sbjct: 2674 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMF 2733
Query: 338 ----------------------TTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
TE + ++ + + A C P + W + +
Sbjct: 2734 QKVGDFSAAFEILSREEEARGGVTEYREIVEN--NPAYLYCDTNAIPPPDLTWYREDQPL 2791
Query: 376 -------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQ 428
VL + L + VR E+AG+Y C+A VG L V PP+I T+
Sbjct: 2792 SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA-SNEVGEDWLHYELLVLTPPVILG-DTE 2849
Query: 429 HALH------GEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVIST 482
+ ++C P P SW +N L S R V E+G +
Sbjct: 2850 ELVEEVTVNASSTVSLQCPALGNPVP---TISWLQNGLPFSPSPRLQV----LEDGQVLQ 2902
Query: 483 LTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLE 528
++ + + A Y C A N GS ++ L+ Q +G LE
Sbjct: 2903 VSTAEVADA---ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLE 2945
Score = 70.1 bits (170), Expect = 7e-12
Identities = 123/504 (24%), Positives = 188/504 (37%), Gaps = 90/504 (17%)
Query: 51 SQQPQDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
S QP + + G P+ LLC P+ + + W KDG AL + S + L V
Sbjct: 3499 SGQPTELSLTPGAPMELLCDAQGTPQPN--ITWHKDGQALTRLENNSRATRVLRV----- 3551
Query: 108 GEHHLKILRAELQDDAVYECQAIQ-AAIRSRPARLTVLVPPDDPVILG--GP--VISLRA 162
+D +Y C A A + R+ V PP+ I+G GP V+ L
Sbjct: 3552 ------------RDAGLYTCLAESPAGAIEKSFRVRVQAPPN---IVGPRGPRFVVGLAP 3596
Query: 163 GDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
G L L C + A+PA I W R G V+ +++ R G+ + + GD
Sbjct: 3597 GQ-LVLECSVE-AEPAPKITWHRDGIVLQEDAHTQFPER-GRFLQLQALSTADSGDYS-- 3651
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQH-------PPLVNLSVEPQPVLEDNVVTFHCSAKA 275
C A N A G + ++I PP VN+SV +L C A
Sbjct: 3652 ----CTARNAA--GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLP-------CQADG 3698
Query: 276 NPAVTQYRWAK----------RGQIIKEASGEVYRTTV-DYTYFSEPVSCEVTNALGSTN 324
PA W K R +I+ E S + D ++ C +N+ GS
Sbjct: 3699 VPAPL-VSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL----CLASNSAGSDR 3753
Query: 325 LSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG---------SGV 375
R + V P + P +L + + A+ C +G+P +VW K G
Sbjct: 3754 QGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY 3813
Query: 376 VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEK 435
L L L + +D+ ++ C V VG R +TV+ PP I+ QT +
Sbjct: 3814 RLLPSNALLLTAPGPQDSAQFEC-VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMA 3872
Query: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQT 495
+ + P ++WS L + SG + + E G +
Sbjct: 3873 PVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR-------- 3924
Query: 496 IYNCTAWNSFGSDTEIIRLKEQGS 519
Y C+A NS G + + L Q S
Sbjct: 3925 -YTCSARNSAGVAHKHVFLTVQAS 3947
Score = 67.4 bits (163), Expect = 5e-11
Identities = 93/349 (26%), Positives = 136/349 (38%), Gaps = 44/349 (12%)
Query: 107 SGEHHLKILRAELQDDAVYECQAIQAAIRSRP-ARLTVLVPPDDPVILGGPVISLRAGDP 165
SGE L + E QD Y C A A R+R LT+LV P + G SLR GD
Sbjct: 4090 SGE--LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR--SLRLGDR 4145
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
L L C A P I W + + DG STL + E+ +
Sbjct: 4146 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQ----DGG-----STLQRAAVSREDSGTY 4195
Query: 226 VCRATNKAIPGGKETSVT-IDIQHPPLVN---LSVEPQPVLEDNVVTFHCSAKANPAVTQ 281
VC A N+ G+ +V+ + ++ P++ S +PV + C + +P V
Sbjct: 4196 VCWAENRV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPV--GGSIQLDCVVRGDP-VPD 4249
Query: 282 YRWAKRG---------QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVY 332
W K G ++ S ++RT D + C N +G + +
Sbjct: 4250 IHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDD---AGRYQCLAENEMGVAKKVVILVLQ 4306
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSN------EKTLTLK 386
P EPQ + V G D C TG P+ TI W++ G + S + +L L+
Sbjct: 4307 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE 4366
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEK 435
+V DAG Y C A +G+ L V G P S ++G K
Sbjct: 4367 NVETGDAGTYDCVA-HNLLGSATARAFLVVRGEPQGSWGSMTGVINGRK 4414
Score = 66.6 bits (161), Expect = 8e-11
Identities = 107/455 (23%), Positives = 174/455 (38%), Gaps = 64/455 (14%)
Query: 59 VVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRD--LSSYPQYLVVGNHLSGEHHLKIL 115
V+ PV L C A ++W+KDG + L +P G L +
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP----------GGRVLTLA 2038
Query: 116 RAELQDDAVYECQAIQAAIRSRP-ARLTVLVPPDDPVILGGPV-ISLRAGDPLNLTCHAD 173
A D Y C A+ A R L V +PP ILG + +S+ A + + L C +
Sbjct: 2039 SARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQS- 2094
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLF-ISPGDVENGQSIVCRATNK 232
+A P + W + G + R G S L + DV + C A N+
Sbjct: 2095 HAMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQ 2146
Query: 233 AIPGGKETSVTIDIQHPPLVNL-SVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
A G E +++ P+ L V E + + C + P + W K GQ +
Sbjct: 2147 A--GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP-FPKISWRKDGQPL 2203
Query: 292 K-EASGEVYRTTVDYTYF--------SEPVSCEVTNALGSTNLSRTVDVYFGPRMT---T 339
E +G + + V + +CE +N +G+++ ++V+ P++
Sbjct: 2204 PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE 2263
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGS------GVVLSNE-KTLTLKSVRQED 392
P + V A C TG P T+ W + G G+ L N+ ++L ++ +
Sbjct: 2264 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAH 2323
Query: 393 AGKYVCRAVVPRVGAGEREVTLTVNGPPIISS-----TQTQHALHGEKGQIKCFIRSTPP 447
G+Y C A G ER+ L+V PP + T ALH + C PP
Sbjct: 2324 TGRYSCVA-ENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL-TLLCEAMGIPP 2381
Query: 448 PDRIAWSWKENVLESG-----TSGRYTVETISTEE 477
P I W E + G +G + ++ T+E
Sbjct: 2382 P-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQE 2415
Score = 65.5 bits (158), Expect = 2e-10
Identities = 106/447 (23%), Positives = 173/447 (38%), Gaps = 77/447 (17%)
Query: 112 LKILRAELQDDAVYECQAIQ-AAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTC 170
L++ + ++ D YEC A A S L V VPP V G V+ + G+ L+L C
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQ--VQPGPRVLKVLVGEALDLNC 1141
Query: 171 HADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRAT 230
A+ P + W + G V+ G G + S V I D + C A+
Sbjct: 1142 VAEG-NPEPQLSWSKDGVVLQGR---------GPQGS-VHFAAIRTSDAGRYR---CEAS 1187
Query: 231 NKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLE---DNVVTFHCSAKANPAVTQYRWAK- 286
N A G V + + PP E +LE + C A+ P Q W K
Sbjct: 1188 NSA--GVDAWEVELRVLEPPHWGAD-ETSGLLERVAGENASLPCPARGTPK-PQVTWRKG 1243
Query: 287 ------RGQ----IIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
GQ +++E G ++ +V S C+ TN +GST+ + VY P
Sbjct: 1244 PSSEPLHGQPGVAVLEE--GSLFLASVSPAD-SGDYECQATNEVGSTSRRAKLVVYVPPS 1300
Query: 337 MTTEPQSLLVD--LGSDAIFSCAWTGNPSLTIVWMKR----------------------G 372
+ + + V G C G P IVW+K G
Sbjct: 1301 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 373 SGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPII---SSTQTQH 429
+L ++L +++ D+G Y CRA + G +R+ L V PP + + Q
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRA-ENQAGTAQRDFHLLVLTPPSVLGAGAAQEVL 1419
Query: 430 ALHGEKGQIKCFIRSTPPPDRIAWSW-KENVLESGTSGRYTVETISTEEGVISTLTISNI 488
L G +++C+ P P ++ W+ ++ VL G + E+G + +T S++
Sbjct: 1420 GLAGADVELQCWTSGVPTP-QVEWTKDRQPVLPGGPHLQV------QEDGQVLRITGSHV 1472
Query: 489 VRADFQTIYNCTAWNSFGSDTEIIRLK 515
+ Y C A++ G +L+
Sbjct: 1473 ---GDEGRYQCVAFSPAGQQARDFQLR 1496
Score = 64.7 bits (156), Expect = 3e-10
Identities = 104/433 (24%), Positives = 151/433 (34%), Gaps = 49/433 (11%)
Query: 105 HLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGD 164
H+ + L I +D Y CQA + + +T+ V V+ + G+
Sbjct: 655 HVDAQGTLIIQGVAPEDAGNYSCQATNE-VGTDQETVTLYYTDPPSVSAVNAVVLVAVGE 713
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
L C A P +IW R G L +G S L I + +
Sbjct: 714 EAVLVCEASGVPPPR-VIWYRGG-------LEMILAPEG---SSSGKLRIPAAQERDAGT 762
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
CRA N+ G + + + H P + V C A P T W
Sbjct: 763 YTCRAVNEL--GDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 819
Query: 285 AKR-----GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDV 331
+ G + G R F E V+ CE N G + V
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 332 --YFGPRMTTEPQSLLVDLGSDAIFSC-AWTGNPSLTIVWMKRG------SGVVLSNEKT 382
+ P++ + ++ V G C G P W+K G S + + +
Sbjct: 880 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS 939
Query: 383 LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH-GEKGQIKCF 441
L L QE AG+Y C A G+ R+V L V PP I T T H + G + C
Sbjct: 940 LHLDRALQEHAGRYSCVAT-NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCV 998
Query: 442 IRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTA 501
P P I W+ + N L S Y V ++EG TL I+ D Y CTA
Sbjct: 999 ASGVPAP-TITWTKETNALTS-RGPHYNV----SKEG---TLLIAQPSAQD-AGAYVCTA 1048
Query: 502 WNSFGSDTEIIRL 514
N+ G ++ +RL
Sbjct: 1049 TNTVGFSSQEMRL 1061
Score = 63.5 bits (153), Expect = 7e-10
Identities = 106/495 (21%), Positives = 179/495 (36%), Gaps = 83/495 (16%)
Query: 64 PVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDD 122
P+TLLC A+ + W + + G D YL+ G + LK+ + + QD
Sbjct: 2369 PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDT-----YLLAGGWM-----LKMTQTQEQDS 2418
Query: 123 AVYECQAI-QAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASI 181
+Y C A +A R + VLVPP VI + G +L C+ P +
Sbjct: 2419 GLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKL 2477
Query: 182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETS 241
W + G + + + DG ++ S G C A N G K
Sbjct: 2478 TWFKDGRPLARGD-AHHISPDGVLLQVLQANLSSAGHYS------CIAANAV--GEKTKH 2528
Query: 242 VTIDIQHPPLV-----NLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG 296
+ + P + + + E V +N ++ C A A P+ W K G EAS
Sbjct: 2529 FQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPS-PNITWMKDGAPF-EASR 2586
Query: 297 EVYRTTVDY--------TYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEP------- 341
+ + + +C VTN LG + V+V P ++ +
Sbjct: 2587 NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGV 2646
Query: 342 QSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV-------VLSNEKTLTLKSVRQEDAG 394
+ + + S C P TI W K G V VL + L ++ + D+G
Sbjct: 2647 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSG 2706
Query: 395 KYVCRAVVPRVGAGEREVTLTVNGPPIISS---------------------TQTQHALHG 433
+Y+C A G +++ + + PP+ T+ + +
Sbjct: 2707 RYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVEN 2765
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADF 493
+ C + PPPD + W ++ L +G + +S +G + +VRA+
Sbjct: 2766 NPAYLYCDTNAIPPPD-LTWYREDQPLSAG-------DEVSVLQG--GRVLQIPLVRAEN 2815
Query: 494 QTIYNCTAWNSFGSD 508
Y+C A N G D
Sbjct: 2816 AGRYSCKASNEVGED 2830
Score = 61.6 bits (148), Expect = 3e-09
Identities = 115/493 (23%), Positives = 176/493 (35%), Gaps = 72/493 (14%)
Query: 60 VSGQPVTLLCAIPEYDGFVL-WIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAE 118
V+G+PV L C + L W +GL + N E +LR E
Sbjct: 1609 VAGRPVALECVARGHPSPTLSWHHEGLPVAES-------------NESRLETDGSVLRLE 1655
Query: 119 LQDDAVYECQAIQAAIRSRPARLTVL-------VPPDDPVILGGPVISLRAGDPLNLTCH 171
+A + + + S PA VL VPP V G ++ G PL L C
Sbjct: 1656 SPGEA---SSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQ 1712
Query: 172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATN 231
A + P +I WL+ G L + S +TL I ++++ C+ATN
Sbjct: 1713 ASGS-PVPTIQWLQNGRPAEE-------LAGVQVASQGTTLHIDHVELDHSGLFACQATN 1764
Query: 232 KAIPGGKETSVTIDIQHPPLVNLSV------------EPQPVLEDNVVTFHCSAKANPAV 279
+A G E V++ + P V L V P D V A P +
Sbjct: 1765 EAGTAGAEVEVSVHGEWAPGV-LEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPL 1823
Query: 280 TQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV--------SCEVTNALGSTNLSRTVDV 331
+ W G + E +G ++ E V +C TN G + + V
Sbjct: 1824 VE-GWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 1882
Query: 332 YFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK------RGSGVVLS-NEKTLT 384
P + P + V + C +G P + W K GV +S + + L
Sbjct: 1883 LVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLR 1942
Query: 385 LKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS--STQTQHALHGEKGQIKCFI 442
++ + DAG Y C A G+ E L VN PP I+ + L ++ C
Sbjct: 1943 IEQAQLSDAGSYRCVA-SNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNA 2001
Query: 443 RSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAW 502
P P + V +GT G G + TL + RA Y+C A
Sbjct: 2002 TGAPSPTLMWLKDGNPVSPAGTPGLQVF-----PGGRVLTLASA---RASDSGRYSCVAV 2053
Query: 503 NSFGSDTEIIRLK 515
++ G D + + L+
Sbjct: 2054 SAVGEDRQDVVLQ 2066
Score = 30.8 bits (68), Expect = 5.0
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 12/81 (14%)
Query: 50 FSQQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSG 108
F +PQD V SG V L C A E + W++ G L R L + P
Sbjct: 4311 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLP----------- 4359
Query: 109 EHHLKILRAELQDDAVYECQA 129
+ L + E D Y+C A
Sbjct: 4360 DGSLWLENVETGDAGTYDCVA 4380
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 99.4 bits (246), Expect = 1e-20
Identities = 123/455 (27%), Positives = 183/455 (40%), Gaps = 58/455 (12%)
Query: 78 VLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSR 137
V W KD AL +G ++ P G H L++ RA L D +Y C+A+ AA R +
Sbjct: 1687 VTWYKDSQALSLGEEVFLLP----------GTHTLQLGRARLSDSGMYTCEALNAAGRDQ 1736
Query: 138 P-ARLTVLVPPDDPVILGGP--VISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGAT 194
+L+VLVPP GP + +R GD L+C D A P ++ W + G+ + A
Sbjct: 1737 KLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD-ALPEPTVTWYKDGQPLVLAQ 1795
Query: 195 YSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPP-LVN 253
++ LR G+R L I V + C+ +N + G + T+ +Q PP N
Sbjct: 1796 RTQA-LRGGQR------LEIQEAQVSDKGLYSCKVSN--VAGEAVRTFTLTVQVPPTFEN 1846
Query: 254 LSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEAS--GEVYRTTVDYTYFSEP 311
E + + + C PA T W K ++ ++ G V R +P
Sbjct: 1847 PKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQP 1905
Query: 312 V-----SCEVTNALGSTNLSRTVDVYFGPRMTTE--PQSLLVDLGSDAIFSCAWTGNPSL 364
+C N V V PR+ + + V G + C G P
Sbjct: 1906 AQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPP 1965
Query: 365 TIVWMKRGSGV---------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLT 415
+ W+K GS + + +L LK +R DAG Y C A P G R T+
Sbjct: 1966 DVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNP-AGEDARLHTVN 2024
Query: 416 VNGPPII----SSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVE 471
V PP I + T + GE + C +R +PP I SW ++ L S R +
Sbjct: 2025 VLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP---IHVSWLKDGLPLPLSQRTLL- 2080
Query: 472 TISTEEGVISTLTISNIVRADFQTIYNCTAWNSFG 506
G TL IS + AD I+ C A + G
Sbjct: 2081 -----HGSGHTLRISKVQLAD-AGIFTCVAASPAG 2109
Score = 94.7 bits (234), Expect = 3e-19
Identities = 122/510 (23%), Positives = 207/510 (40%), Gaps = 85/510 (16%)
Query: 55 QDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHH 111
++ V P++L+C A P + + W+KDG R++ P G H
Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPN--ITWMKDGAPFEASRNIQLLP----------GTHG 1314
Query: 112 LKILRAELQDDAVYEC---QAIQAAIRSRPARLTVLVPP----DDPVI-LGGPVISLRAG 163
L+IL A+ +D Y C + A+++ + VL+PP DDP+ +G + +
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAVKNY--HVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372
Query: 164 DPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQ 223
L L C + A P +I W + G+ + ++ + +L +G+ L I P V +
Sbjct: 1373 STLTLECESW-AVPPPTIRWYKDGQPVTPSSRLQ-VLGEGR------LLQIQPTQVSDSG 1424
Query: 224 SIVCRATNKAIPGGKETSVTIDIQHPPLVN-----------LSVEPQP---------VLE 263
+C ATN A G + + IQ PP+ LS E + ++E
Sbjct: 1425 RYLCVATNVA--GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVE 1482
Query: 264 DNVVTFHCSAKANPA--VTQYRWAKRGQIIKEAS----GEVYRTTVDYTYFSEPVSCEVT 317
+N +C A P +T YR + E S G V + + + SC+ +
Sbjct: 1483 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS 1542
Query: 318 NALGSTNLSRTVDVYFGPRMTTEPQSLL----VDLGSDAIFSCAWTGNPSLTIVWMKRGS 373
N +G L + V P + + + L+ V+ S C GNP TI W++ G
Sbjct: 1543 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL 1602
Query: 374 GV-------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQ 426
VL + + L + + DA Y+C A + G+ E+ TL V PP I+
Sbjct: 1603 PFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE-NQAGSAEKLFTLRVQVPPRIAGLD 1661
Query: 427 TQH--ALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLT 484
+ A+ + C + + P P+ + W L G E + G TL
Sbjct: 1662 LEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLG-------EEVFLLPGT-HTLQ 1712
Query: 485 ISNIVRADFQTIYNCTAWNSFGSDTEIIRL 514
+ +D +Y C A N+ G D ++++L
Sbjct: 1713 LGRARLSD-SGMYTCEALNAAGRDQKLVQL 1741
Score = 88.6 bits (218), Expect = 2e-17
Identities = 106/420 (25%), Positives = 166/420 (39%), Gaps = 52/420 (12%)
Query: 56 DQVVVSGQPVTLLCAIPEYD-GFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 114
D VVV G V L C V W+KDG L + + L P L++
Sbjct: 2133 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL-LSQSLEQGPS-------------LQL 2178
Query: 115 LRAELQDDAVYECQAI-QAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHAD 173
D Y C A+ +A R +LTV+ PP +SL G P+ L C A
Sbjct: 2179 EAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ 2238
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKA 233
P +I W + G+ + T L + R + V V + C A + A
Sbjct: 2239 GT-PQPNITWHKDGQAL-------TRLENNSRATRVLR-------VRDAGLYTCLAESPA 2283
Query: 234 IPGGKETSVTIDIQHPPLVNLSVEPQPV--LEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
G E S + +Q PP + P+ V L + CS +A PA + W + G ++
Sbjct: 2284 --GAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPA-PKITWHRDGIVL 2340
Query: 292 KEAS-------GEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSL 344
+E + G + T S SC NA GST+++ V+++ P + + P ++
Sbjct: 2341 QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAV 2400
Query: 345 LVDLGSDAIFSCAWTGNPSLTIVWMK-------RGSGVVLSNEKTLTLKSVRQEDAGKYV 397
V + A+ C G P+ + W K R + E +L ++ V +DAG Y+
Sbjct: 2401 NVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL 2460
Query: 398 CRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKE 457
C A G+ + L V PP I+ + + L + S P + W WK+
Sbjct: 2461 CLA-SNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVW-WKD 2518
Score = 83.2 bits (204), Expect = 9e-16
Identities = 117/484 (24%), Positives = 182/484 (37%), Gaps = 64/484 (13%)
Query: 60 VSGQPVTLLCAIPEYDGF----VLWIKDGLALGVGRDLSSYPQYL---VVGNH--LSGEH 110
++GQ +TL C + +GF ++W+KD +GV + Y L VG H L
Sbjct: 31 MAGQSLTLEC---DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 87
Query: 111 HLKILRAELQDDAVYECQAI-QAAIRSRPARLTVLVPPDDPVILGG----PVISLRAGDP 165
L R + D +Y C+A QA R L VL PP +LG V+ L AG
Sbjct: 88 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS---VLGAGAAQEVLGL-AGAD 143
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
+ L C P + W + + + + DG+ L I+ V +
Sbjct: 144 VELQCWTSGV-PTPQVEWTKDRQPVLPGGPHLQVQEDGQ------VLRITGSHVGDEGRY 196
Query: 226 VCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPV--LEDNVVTFHCSAKANPAVTQYR 283
C A + A G + + + PP + S E V +ED++V C A+ P
Sbjct: 197 QCVAFSPA--GQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPT-PNIT 253
Query: 284 WAKRGQIIKEASGEVYRTTVDYTYFSEPVS-------CEVTNALGSTNLSRTVDVYFGPR 336
W K G ++ ++ VY S C+ +NA+G+ + +DVY P
Sbjct: 254 WFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 313
Query: 337 MTT---EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE-------KTLTLK 386
+ P + G C G+PS T+ W G V SNE L L+
Sbjct: 314 IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLE 373
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP---IISSTQTQHALHGEKGQIKCFIR 443
S + +G Y C A P G + ++ V PP + + G+ ++ C
Sbjct: 374 SPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQAS 432
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
+P P W +N GR E + T + V D ++ C A N
Sbjct: 433 GSPVP---TIQWLQN-------GRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN 482
Query: 504 SFGS 507
G+
Sbjct: 483 EAGT 486
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/271 (28%), Positives = 114/271 (42%), Gaps = 28/271 (10%)
Query: 207 SIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNV 266
S+ L I D+ + C ATN A G + V + + PP + + VLE+
Sbjct: 563 SLPPPLQIEKVDLRDEGIYTCAATNLA--GESKREVALKVLVPPNIEPGPVNKAVLENAS 620
Query: 267 VTFHCSAKANPAVTQYRWAKRGQIIKE-------ASGEVYRTTVDYTYFSEPVSCEVTNA 319
VT C A P W K Q + G V R + C +N
Sbjct: 621 VTLECLASGVPP-PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNV 679
Query: 320 LGSTNLSRTVDVYFGPRMTTEPQ---SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV- 375
GST L + V PR+T P +LV+ + +C TG PS T++W+K G+ V
Sbjct: 680 AGSTELRYGLRVNVPPRITLPPSLPGPVLVN--TPVRLTCNATGAPSPTLMWLKDGNPVS 737
Query: 376 --------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP-IISSTQ 426
V + LTL S R D+G+Y C A V VG ++V L V+ PP I+
Sbjct: 738 PAGTPGLQVFPGGRVLTLASARASDSGRYSCVA-VSAVGEDRQDVVLQVHMPPSILGEEL 796
Query: 427 TQHALHGEKGQIKCFIRSTPPPDRIAWSWKE 457
+ E ++C + PPP ++W WK+
Sbjct: 797 NVSVVANESVALECQSHAMPPP-VLSW-WKD 825
Score = 81.3 bits (199), Expect = 3e-15
Identities = 108/426 (25%), Positives = 166/426 (38%), Gaps = 46/426 (10%)
Query: 112 LKILRAELQDDAVYECQAIQAAIRS-RPARLTVLVPPDDPVILGGPVI-SLRAGDPLNLT 169
L+I + +L+D+ +Y C A A S R L VLVPP+ I GPV ++ + L
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASVTLE 624
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRA 229
C A P + W KG + T+ DG+ L I + + S C A
Sbjct: 625 CLASGVPPP-DVSWF-KGHQPVSSWMGVTVSVDGR------VLRIEQAQLSDAGSYRCVA 676
Query: 230 TNKAIPGGKETSVTIDIQHPPLVNLSVE-PQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
+N A G E + + PP + L P PVL + V C+A P+ T W K G
Sbjct: 677 SNVA--GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLKDG 733
Query: 289 QIIKEAS---------GEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTT 339
+ A G V S SC +A+G + V+ P +
Sbjct: 734 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 793
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG------SGVVLSNEKTLTLKSVRQE-- 391
E ++ V C P + W K G GV LS +K L L+ R +
Sbjct: 794 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL-LQVDRADVW 852
Query: 392 DAGKYVCRAVVPRVGAGEREVTLTVNGPPI--ISSTQTQHALHGEKGQIKCFIRSTPPPD 449
DAG Y C A + + G E+ L V P+ + + T G ++ C R P P
Sbjct: 853 DAGHYTCEA-LNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFP- 910
Query: 450 RIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDT 509
+I+W L +G V + G + L + + + + Y C N G+ +
Sbjct: 911 KISWRKDGQPLPGEGAGLQHVSAV----GRLLYLGQAQLAQ---EGTYTCECSNVVGNSS 963
Query: 510 EIIRLK 515
+ ++L+
Sbjct: 964 QDLQLE 969
Score = 79.0 bits (193), Expect = 2e-14
Identities = 107/423 (25%), Positives = 161/423 (38%), Gaps = 57/423 (13%)
Query: 109 EHHLKILRAELQDDAVYECQAIQAAIRSRPAR-LTVLVPPDDPVILGGPV-ISLRAGDPL 166
E L+I QD Y C A +A R R L VL PP I P ++L A P
Sbjct: 2443 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP---AIAPSPSNLTLTAHTPA 2499
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVST--LFISPGDVENGQS 224
L C A + P ++W + G+ ++ L+ G + S L +PG ++ Q
Sbjct: 2500 LLPCEASGS-PKPLVVWWKDGQKLDFR------LQQGAYRLLPSNALLLTAPGPQDSAQ- 2551
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
C +N+ + VT+ + PP + V V C + PA T W
Sbjct: 2552 FECVVSNEVGEAHRLYQVTVHV--PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSW 2608
Query: 285 AKRGQIIKEASGEVYRTTVD--------YTYFSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
+K G + A G YR + + +C N+ G + + V P
Sbjct: 2609 SKAGAQLG-ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2667
Query: 337 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK------TLTLKSVRQ 390
+ P + + + C +G P TI W K G V L +
Sbjct: 2668 VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASP 2727
Query: 391 EDAGKYVCRAVVPRVGAGEREVTLTVNGPPII-------SSTQTQHALHGEKGQIKCFIR 443
EDAG Y+C A G+ + L V PP+I S+T+ HA + C R
Sbjct: 2728 EDAGNYLCIA-KNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAF------LPCKAR 2780
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
+P P+ I W K+ SG G++T++ L + N+ D T Y CTA N
Sbjct: 2781 GSPEPN-ITWD-KDGQPVSGAEGKFTIQP-------SGELLVKNLEGQDAGT-YTCTAEN 2830
Query: 504 SFG 506
+ G
Sbjct: 2831 AVG 2833
Score = 71.6 bits (174), Expect = 3e-12
Identities = 122/526 (23%), Positives = 195/526 (37%), Gaps = 93/526 (17%)
Query: 59 VVSGQPVTLLCAIPEYDGFVL-WIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHL-KILR 116
V+ GQ L+C + + L W KDG L G +H+S + L ++L+
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD-----------AHHISPDGVLLQVLQ 1223
Query: 117 AELQDDAVYECQAIQAA-IRSRPARLTVLVPPDDPVILGGPV------ISLRAGDPLNLT 169
A L Y C A A +++ +L+VL+ P ILGG +++ +P++L
Sbjct: 1224 ANLSSAGHYSCIAANAVGEKTKHFQLSVLLAP---TILGGAEDSADEEVTVTVNNPISLI 1280
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRA 229
C A A P+ +I W++ G + + L L I E+ C
Sbjct: 1281 CEA-LAFPSPNITWMKDGAPFEASRNIQLLPG-------THGLQILNAQKEDAGQYTCVV 1332
Query: 230 TNKAIPGGKETSVTIDI-----QHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
TN+ K V + I + PL + V+ ++ +T C + A P T RW
Sbjct: 1333 TNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPT-IRW 1391
Query: 285 AKRGQIIKEAS-----GEVYRTTVDYTYFSEP--VSCEVTNALGSTNLSRTVDVYFGPRM 337
K GQ + +S GE + T S+ C TN G + V + P
Sbjct: 1392 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMF 1451
Query: 338 ----------------------TTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
TE + ++ + + A C P + W + +
Sbjct: 1452 QKVGDFSAAFEILSREEEARGGVTEYREIVEN--NPAYLYCDTNAIPPPDLTWYREDQPL 1509
Query: 376 -------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQ 428
VL + L + VR E+AG+Y C+A VG L V PP+I T+
Sbjct: 1510 SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKA-SNEVGEDWLHYELLVLTPPVILG-DTE 1567
Query: 429 HALH------GEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVIST 482
+ ++C P P SW +N L S R V E+G +
Sbjct: 1568 ELVEEVTVNASSTVSLQCPALGNPVP---TISWLQNGLPFSPSPRLQV----LEDGQVLQ 1620
Query: 483 LTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLE 528
++ + + A Y C A N GS ++ L+ Q +G LE
Sbjct: 1621 VSTAEVADA---ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLE 1663
Score = 70.1 bits (170), Expect = 7e-12
Identities = 123/504 (24%), Positives = 188/504 (37%), Gaps = 90/504 (17%)
Query: 51 SQQPQDQVVVSGQPVTLLC---AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
S QP + + G P+ LLC P+ + + W KDG AL + S + L V
Sbjct: 2217 SGQPTELSLTPGAPMELLCDAQGTPQPN--ITWHKDGQALTRLENNSRATRVLRV----- 2269
Query: 108 GEHHLKILRAELQDDAVYECQAIQ-AAIRSRPARLTVLVPPDDPVILG--GP--VISLRA 162
+D +Y C A A + R+ V PP+ I+G GP V+ L
Sbjct: 2270 ------------RDAGLYTCLAESPAGAIEKSFRVRVQAPPN---IVGPRGPRFVVGLAP 2314
Query: 163 GDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
G L L C + A+PA I W R G V+ +++ R G+ + + GD
Sbjct: 2315 GQ-LVLECSVE-AEPAPKITWHRDGIVLQEDAHTQFPER-GRFLQLQALSTADSGDYS-- 2369
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQH-------PPLVNLSVEPQPVLEDNVVTFHCSAKA 275
C A N A G + ++I PP VN+SV +L C A
Sbjct: 2370 ----CTARNAA--GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLP-------CQADG 2416
Query: 276 NPAVTQYRWAK----------RGQIIKEASGEVYRTTV-DYTYFSEPVSCEVTNALGSTN 324
PA W K R +I+ E S + D ++ C +N+ GS
Sbjct: 2417 VPAPL-VSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL----CLASNSAGSDR 2471
Query: 325 LSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG---------SGV 375
R + V P + P +L + + A+ C +G+P +VW K G
Sbjct: 2472 QGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY 2531
Query: 376 VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEK 435
L L L + +D+ ++ C V VG R +TV+ PP I+ QT +
Sbjct: 2532 RLLPSNALLLTAPGPQDSAQFEC-VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMA 2590
Query: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQT 495
+ + P ++WS L + SG + + E G +
Sbjct: 2591 PVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR-------- 2642
Query: 496 IYNCTAWNSFGSDTEIIRLKEQGS 519
Y C+A NS G + + L Q S
Sbjct: 2643 -YTCSARNSAGVAHKHVFLTVQAS 2665
Score = 65.9 bits (159), Expect = 1e-10
Identities = 107/455 (23%), Positives = 173/455 (38%), Gaps = 64/455 (14%)
Query: 59 VVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRD--LSSYPQYLVVGNHLSGEHHLKIL 115
V+ PV L C A ++W+KDG + L +P G L +
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFP----------GGRVLTLA 756
Query: 116 RAELQDDAVYECQAIQAAIRSRP-ARLTVLVPPDDPVILGGPV-ISLRAGDPLNLTCHAD 173
A D Y C A+ A R L V +PP ILG + +S+ A + + L C +
Sbjct: 757 SARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQS- 812
Query: 174 NAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLF-ISPGDVENGQSIVCRATNK 232
+A P + W + G + R G S L + DV + C A N+
Sbjct: 813 HAMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQ 864
Query: 233 AIPGGKETSVTIDIQHPPLVNL-SVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
A G E +++ P+ L V E + C + P + W K GQ +
Sbjct: 865 A--GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVP-FPKISWRKDGQPL 921
Query: 292 K-EASGEVYRTTVDYTYF--------SEPVSCEVTNALGSTNLSRTVDVYFGPRMT---T 339
E +G + + V + +CE +N +G+++ ++V+ P++
Sbjct: 922 PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPRE 981
Query: 340 EPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGS------GVVLSNE-KTLTLKSVRQED 392
P + V A C TG P T+ W + G G+ L N+ ++L ++ +
Sbjct: 982 PPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAH 1041
Query: 393 AGKYVCRAVVPRVGAGEREVTLTVNGPPIISS-----TQTQHALHGEKGQIKCFIRSTPP 447
G+Y C A G ER+ L+V PP + T ALH + C PP
Sbjct: 1042 TGRYSCVA-ENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL-TLLCEAMGIPP 1099
Query: 448 PDRIAWSWKENVLESG-----TSGRYTVETISTEE 477
P I W E + G +G + ++ T+E
Sbjct: 1100 P-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQE 1133
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/349 (26%), Positives = 135/349 (38%), Gaps = 44/349 (12%)
Query: 107 SGEHHLKILRAELQDDAVYECQAIQAAIRSRP-ARLTVLVPPDDPVILGGPVISLRAGDP 165
SGE L + E QD Y C A A R+R LT+LV P + G SLR GD
Sbjct: 2808 SGE--LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR--SLRLGDR 2863
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
L L C A P I W + + DG STL + E+ +
Sbjct: 2864 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQ----DGG-----STLQRAAVSREDSGTY 2913
Query: 226 VCRATNKAIPGGKETSVT-IDIQHPPLVN---LSVEPQPVLEDNVVTFHCSAKANPAVTQ 281
VC A N+ G+ +V+ + ++ P++ S +PV + C + +P V
Sbjct: 2914 VCWAENRV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPV--GGSIQLDCVVRGDP-VPD 2967
Query: 282 YRWAKRG---------QIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVY 332
W K G ++ S + RT D + C N +G + +
Sbjct: 2968 IHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDD---AGRYQCLAENEMGVAKKVVILVLQ 3024
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSN------EKTLTLK 386
P EPQ + V G D C TG P+ TI W++ G + S + +L L+
Sbjct: 3025 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLE 3084
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEK 435
+V DAG Y C A +G+ L V G P S ++G K
Sbjct: 3085 NVETGDAGTYDCVA-HNLLGSATARAFLVVRGEPQGSWGSMTGVINGRK 3132
Score = 63.5 bits (153), Expect = 7e-10
Identities = 106/495 (21%), Positives = 179/495 (36%), Gaps = 83/495 (16%)
Query: 64 PVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDD 122
P+TLLC A+ + W + + G D YL+ G + LK+ + + QD
Sbjct: 1087 PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDT-----YLLAGGWM-----LKMTQTQEQDS 1136
Query: 123 AVYECQAI-QAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASI 181
+Y C A +A R + VLVPP VI + G +L C+ P +
Sbjct: 1137 GLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV-TGHPQPKL 1195
Query: 182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETS 241
W + G + + + DG ++ S G C A N G K
Sbjct: 1196 TWFKDGRPLARGD-AHHISPDGVLLQVLQANLSSAGHYS------CIAANAV--GEKTKH 1246
Query: 242 VTIDIQHPPLV-----NLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG 296
+ + P + + + E V +N ++ C A A P+ W K G EAS
Sbjct: 1247 FQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPS-PNITWMKDGAPF-EASR 1304
Query: 297 EVYRTTVDY--------TYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEP------- 341
+ + + +C VTN LG + V+V P ++ +
Sbjct: 1305 NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGV 1364
Query: 342 QSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV-------VLSNEKTLTLKSVRQEDAG 394
+ + + S C P TI W K G V VL + L ++ + D+G
Sbjct: 1365 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSG 1424
Query: 395 KYVCRAVVPRVGAGEREVTLTVNGPPIISS---------------------TQTQHALHG 433
+Y+C A G +++ + + PP+ T+ + +
Sbjct: 1425 RYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVEN 1483
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADF 493
+ C + PPPD + W ++ L +G + +S +G + +VRA+
Sbjct: 1484 NPAYLYCDTNAIPPPD-LTWYREDQPLSAG-------DEVSVLQG--GRVLQIPLVRAEN 1533
Query: 494 QTIYNCTAWNSFGSD 508
Y+C A N G D
Sbjct: 1534 AGRYSCKASNEVGED 1548
Score = 61.6 bits (148), Expect = 3e-09
Identities = 115/493 (23%), Positives = 176/493 (35%), Gaps = 72/493 (14%)
Query: 60 VSGQPVTLLCAIPEYDGFVL-WIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAE 118
V+G+PV L C + L W +GL + N E +LR E
Sbjct: 327 VAGRPVALECVARGHPSPTLSWHHEGLPVAES-------------NESRLETDGSVLRLE 373
Query: 119 LQDDAVYECQAIQAAIRSRPARLTVL-------VPPDDPVILGGPVISLRAGDPLNLTCH 171
+A + + + S PA VL VPP V G ++ G PL L C
Sbjct: 374 SPGEA---SSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQ 430
Query: 172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATN 231
A + P +I WL+ G L + S +TL I ++++ C+ATN
Sbjct: 431 ASGS-PVPTIQWLQNGRPAEE-------LAGVQVASQGTTLHIDHVELDHSGLFACQATN 482
Query: 232 KAIPGGKETSVTIDIQHPPLVNLSV------------EPQPVLEDNVVTFHCSAKANPAV 279
+A G E V++ + P V L V P D V A P +
Sbjct: 483 EAGTAGAEVEVSVHGEWAPGV-LEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPL 541
Query: 280 TQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV--------SCEVTNALGSTNLSRTVDV 331
+ W G + E +G ++ E V +C TN G + + V
Sbjct: 542 VE-GWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 600
Query: 332 YFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK------RGSGVVLS-NEKTLT 384
P + P + V + C +G P + W K GV +S + + L
Sbjct: 601 LVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLR 660
Query: 385 LKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS--STQTQHALHGEKGQIKCFI 442
++ + DAG Y C A G+ E L VN PP I+ + L ++ C
Sbjct: 661 IEQAQLSDAGSYRCVA-SNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNA 719
Query: 443 RSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAW 502
P P + V +GT G G + TL + RA Y+C A
Sbjct: 720 TGAPSPTLMWLKDGNPVSPAGTPGLQVF-----PGGRVLTLASA---RASDSGRYSCVAV 771
Query: 503 NSFGSDTEIIRLK 515
++ G D + + L+
Sbjct: 772 SAVGEDRQDVVLQ 784
Score = 30.8 bits (68), Expect = 5.0
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 12/81 (14%)
Query: 50 FSQQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSG 108
F +PQD V SG V L C A E + W++ G L R L + P
Sbjct: 3029 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLP----------- 3077
Query: 109 EHHLKILRAELQDDAVYECQA 129
+ L + E D Y+C A
Sbjct: 3078 DGSLWLENVETGDAGTYDCVA 3098
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 98.6 bits (244), Expect = 2e-20
Identities = 100/405 (24%), Positives = 170/405 (41%), Gaps = 41/405 (10%)
Query: 63 QPVTLLCAIPEYDGFVLWIKDGLA-LGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQD 121
QP+ + C++ F L ++ G A LG R SG +ILRA +
Sbjct: 325 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQE-----------SGNSSWEILRASKAE 373
Query: 122 DAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASI 181
+ YEC A+ A R A+ ++V P ++ P +++ G+ L+C P ++
Sbjct: 374 EGTYECTAVSRAGTGR-AKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAP-YNL 431
Query: 182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETS 241
W+R V+ +T L D +L IS +G C A+N G S
Sbjct: 432 TWVRDWRVLPASTGRVAQLAD-------LSLEISGIIPTDGGRYQCVASN--ANGVTRAS 482
Query: 242 VTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG---EV 298
V + ++ P V++ Q + V CSA P W++ Q ++E S +
Sbjct: 483 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP-TPHISWSRESQALQEDSRIHVDA 541
Query: 299 YRTTVDYTYFSEPV---SCEVTNALGSTNLSRTVDVYF--GPRMTTEPQSLLVDLGSDAI 353
T + E SC+ TN +G+ TV +Y+ P ++ +LV +G +A+
Sbjct: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTD--QETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
Query: 354 FSCAWTGNPSLTIVWMKRGSGVVLSNEKT----LTLKSVRQEDAGKYVCRAVVPRVGAGE 409
C +G P ++W + G ++L+ E + L + + ++ DAG Y CRA V +G
Sbjct: 600 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA-VNELGDAS 658
Query: 410 REVTLTVNGPPIISSTQTQHALH-GEKGQIKCFIRSTPPPDRIAW 453
E+ L V P ++ + G + C PPP + W
Sbjct: 659 AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVTW 702
Score = 86.3 bits (212), Expect = 1e-16
Identities = 128/499 (25%), Positives = 191/499 (38%), Gaps = 81/499 (16%)
Query: 58 VVVSGQPVTLLCAIPEYDGF----VLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLK 113
+V G+ L+C E G V+W + GL + + + SS SG+ L+
Sbjct: 591 LVAVGEEAVLVC---EASGVPPPRVIWYRGGLEMILAPEGSS-----------SGK--LR 634
Query: 114 ILRAELQDDAVYECQA----------IQAAIRSRPARLTVLVPPDDPVILGGPVISLRAG 163
I A+ +D Y C+A IQ A+ P +LT L P D V LG +
Sbjct: 635 IPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-QLTEL-PRDVTVELGRSAL----- 687
Query: 164 DPLNLTCHADNAKPAASIIWLR-KGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
L C A +P ++ W R G+ + + R + +S V LF E+
Sbjct: 688 ----LACRA-TGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV--LFFESVAPEDQ 740
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQY 282
VC A N E + + PP + S VLE V+ C A + +
Sbjct: 741 APYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER 800
Query: 283 RWAKRGQIIKEASGEVYRTTVDYTY------FSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
W K G+ + S R + SC TN GS + + V PR
Sbjct: 801 HWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR 860
Query: 337 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK-------RGSGVVLSNEKTLTLKSVR 389
+ + + G A C +G P+ TI W K RG +S E TL +
Sbjct: 861 IHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPS 920
Query: 390 QEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQH--------ALHGEKGQIKCF 441
+DAG YVC A VG +E+ L+VN P I +++ A GE+ + C
Sbjct: 921 AQDAGAYVCTA-TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCE 979
Query: 442 IRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI--STLTISNIVRADFQTIYNC 499
+ +PPP L + T V I+ G++ +L ++ + D Y C
Sbjct: 980 AKGSPPP-----------LVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGD-SGHYEC 1027
Query: 500 TAWNSFGSDTEIIRLKEQG 518
TA N GS + L QG
Sbjct: 1028 TASNPAGSASHRYVLGVQG 1046
Score = 79.3 bits (194), Expect = 1e-14
Identities = 102/416 (24%), Positives = 159/416 (38%), Gaps = 42/416 (10%)
Query: 121 DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS 180
D Y+C A A +R A + +LV V + G + ++C A + P
Sbjct: 464 DGGRYQCVASNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPH 521
Query: 181 IIWLRKGEVINGATYSKTLLRDGK-RESIVSTLFISPGDVENGQSIVCRATNKAIPGGKE 239
I W R+ S+ L D + TL I E+ + C+ATN+ G +
Sbjct: 522 ISWSRE---------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV--GTDQ 570
Query: 240 TSVTIDIQHPPLVNL--SVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGE 297
+VT+ PP V+ +V V E+ V+ S P V YR + E S
Sbjct: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS 630
Query: 298 -VYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSC 356
R + +C N LG + + V P++T P+ + V+LG A+ +C
Sbjct: 631 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLAC 690
Query: 357 AWTGNPSLTIVWMK-------------RGSGVVLSNEKTLTLKSVRQEDAGKYVCRA--V 401
TG P T+ W + RGS + L +SV ED YVC A V
Sbjct: 691 RATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNV 750
Query: 402 VPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLE 461
+V A R + P I SS T L G+ + C + + P W L
Sbjct: 751 FGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 810
Query: 462 SGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQ 517
G+ R+++ +L + ++ + Y+C A N+ GS + L Q
Sbjct: 811 PGS--RHSIR-------ADGSLHLDRALQ-EHAGRYSCVATNTAGSQHRDVELVVQ 856
Score = 65.9 bits (159), Expect = 1e-10
Identities = 108/455 (23%), Positives = 157/455 (34%), Gaps = 49/455 (10%)
Query: 105 HLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGD 164
H+ + L I +D Y CQA + + +T+ V V+ + G+
Sbjct: 538 HVDAQGTLIIQGVAPEDAGNYSCQATNE-VGTDQETVTLYYTDPPSVSAVNAVVLVAVGE 596
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
L C A P +IW R G L +G S L I + +
Sbjct: 597 EAVLVCEASGVPPPR-VIWYRGG-------LEMILAPEG---SSSGKLRIPAAQERDAGT 645
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
CRA N+ G + + + H P + V C A P T W
Sbjct: 646 YTCRAVNEL--GDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTW 702
Query: 285 AKR-----GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDV 331
+ G + G R F E V+ CE N G + V
Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
Query: 332 --YFGPRMTTEPQSLLVDLGSDAIFSC-AWTGNPSLTIVWMKRG------SGVVLSNEKT 382
+ P++ + ++ V G C G P W+K G S + + +
Sbjct: 763 TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS 822
Query: 383 LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH-GEKGQIKCF 441
L L QE AG+Y C A G+ R+V L V PP I T T H + G + C
Sbjct: 823 LHLDRALQEHAGRYSCVAT-NTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCV 881
Query: 442 IRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTA 501
P P I W+ + N L S Y V ++EG TL I+ D Y CTA
Sbjct: 882 ASGVPAPT-ITWTKETNALTS-RGPHYNV----SKEG---TLLIAQPSAQDAGA-YVCTA 931
Query: 502 WNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAV 536
N+ G ++ +RL G +VP+ V
Sbjct: 932 TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQV 966
>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
Length = 388
Score = 94.4 bits (233), Expect = 4e-19
Identities = 74/300 (24%), Positives = 132/300 (44%), Gaps = 17/300 (5%)
Query: 53 QPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGL--ALGVGRDLSSYPQYLVVGNHLSGEH 110
Q ++ V G + C + +YDG ++ I++ L + + +
Sbjct: 28 QTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRV 87
Query: 111 HLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRA--GDPLNL 168
+++ A L+D+ Y CQ + A LTVLV P++PV+ + +A G + L
Sbjct: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVV----EVREQAVEGGEVEL 143
Query: 169 TCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
+C ++PAA++ W R + + G + S+ +GK S+ ST+ ++G I+C
Sbjct: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQ---ENGKVWSVASTVRFRVDRKDDGGIIICE 200
Query: 229 ATNKAIPGG--KETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAK 286
A N+A+P G K+T +D+Q+ P + V E + + C+ NP Q RW +
Sbjct: 201 AQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNR 260
Query: 287 RGQII---KEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQS 343
+ + EA GE + + +CE +N G + VY P E Q+
Sbjct: 261 GNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVY-DPGAVVEAQT 319
Score = 41.6 bits (96), Expect = 0.003
Identities = 46/188 (24%), Positives = 70/188 (37%), Gaps = 20/188 (10%)
Query: 259 QPVLEDNVVTFHCSAKANPAVTQYRWAK-----RGQIIKEASGEVY------RTTVDYTY 307
+ +E V C + RW + +G + +G+V+ R VD
Sbjct: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192
Query: 308 FSEPVSCEVTN-ALGSTNLSRT---VDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPS 363
+ CE N AL S + +T +DV + P +V G + +CA TGNP
Sbjct: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252
Query: 364 LTIVWMKRGSGVVLSNE----KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP 419
+ RG+ + +TLTL + D G Y C A + G L V P
Sbjct: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA-SNKHGHARALYVLVVYDP 311
Query: 420 PIISSTQT 427
+ QT
Sbjct: 312 GAVVEAQT 319
>gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens]
Length = 398
Score = 93.6 bits (231), Expect = 6e-19
Identities = 65/240 (27%), Positives = 106/240 (44%), Gaps = 8/240 (3%)
Query: 56 DQVVVSGQPVTLLCAIPEY-DGFVLW---IKDGLALGVGRDLSSYPQYLVVGNHLSGEHH 111
D+ VV+G V L C + ++ D + W + L G R L LV E
Sbjct: 37 DETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTST--PHELS 94
Query: 112 LKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCH 171
+ I L D+ Y C +R+ + +TVL P P+I G SLR D L C
Sbjct: 95 ISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKS-SLREKDTATLNCQ 153
Query: 172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATN 231
+ +KPAA + W + + ++G +GK ++ S++ ++G SIVC +
Sbjct: 154 SSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNH 213
Query: 232 KAIPGG-KETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQI 290
+++ G + TS I++ + P + +P E + HC + NP QY W K G +
Sbjct: 214 ESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSV 273
Score = 30.0 bits (66), Expect = 8.6
Identities = 39/186 (20%), Positives = 70/186 (37%), Gaps = 23/186 (12%)
Query: 373 SGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN---GPPIISSTQTQH 429
+G + ++T + R++D VC + +R + + P + H
Sbjct: 184 NGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPH 243
Query: 430 ALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIV 489
G+K + C R P P + W + +V T+E S L +
Sbjct: 244 PREGQKLLLHCEGRGNPVPQQYLWEKEGSV----------PPLKMTQE---SALIFPFLN 290
Query: 490 RADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFL 549
++D T Y CTA ++ GS L + + + + S IIG + A + FL
Sbjct: 291 KSDSGT-YGCTATSNMGSYKAYYTL-----NVNDPSPVPSSSSTYHAIIG-GIVAFIVFL 343
Query: 550 VLMATI 555
+L+ I
Sbjct: 344 LLIMLI 349
>gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens]
Length = 432
Score = 93.6 bits (231), Expect = 6e-19
Identities = 65/240 (27%), Positives = 106/240 (44%), Gaps = 8/240 (3%)
Query: 56 DQVVVSGQPVTLLCAIPEY-DGFVLW---IKDGLALGVGRDLSSYPQYLVVGNHLSGEHH 111
D+ VV+G V L C + ++ D + W + L G R L LV E
Sbjct: 71 DETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTST--PHELS 128
Query: 112 LKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCH 171
+ I L D+ Y C +R+ + +TVL P P+I G SLR D L C
Sbjct: 129 ISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKS-SLREKDTATLNCQ 187
Query: 172 ADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATN 231
+ +KPAA + W + + ++G +GK ++ S++ ++G SIVC +
Sbjct: 188 SSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNH 247
Query: 232 KAIPGG-KETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQI 290
+++ G + TS I++ + P + +P E + HC + NP QY W K G +
Sbjct: 248 ESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSV 307
Score = 30.0 bits (66), Expect = 8.6
Identities = 39/186 (20%), Positives = 70/186 (37%), Gaps = 23/186 (12%)
Query: 373 SGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN---GPPIISSTQTQH 429
+G + ++T + R++D VC + +R + + P + H
Sbjct: 218 NGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPH 277
Query: 430 ALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIV 489
G+K + C R P P + W + +V T+E S L +
Sbjct: 278 PREGQKLLLHCEGRGNPVPQQYLWEKEGSV----------PPLKMTQE---SALIFPFLN 324
Query: 490 RADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFL 549
++D T Y CTA ++ GS L + + + + S IIG + A + FL
Sbjct: 325 KSDSGT-YGCTATSNMGSYKAYYTL-----NVNDPSPVPSSSSTYHAIIG-GIVAFIVFL 377
Query: 550 VLMATI 555
+L+ I
Sbjct: 378 LLIMLI 383
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 92.0 bits (227), Expect = 2e-18
Identities = 104/437 (23%), Positives = 168/437 (38%), Gaps = 43/437 (9%)
Query: 35 AKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGF-VLWIKDGLALGVGRDL 93
+K FR SF++Q +D G PVTL C + V W +DG+ L +L
Sbjct: 6162 SKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENL 6221
Query: 94 SSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQA-AIRSRPARLTVLVPPDDPVI 152
+ + + LKIL+ +L Y C A S ARLT P P
Sbjct: 6222 QT--------SFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFF 6273
Query: 153 LGGPV-ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVIN-GATYSKTLLRDGKRESIVS 210
PV I + AG+ + CH A+P I W + + I G Y+ T + + I+
Sbjct: 6274 DIKPVSIDVIAGESADFECHVTGAQPMR-ITWSKDNKEIRPGGNYTITCVGNTPHLRILK 6332
Query: 211 TLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNV-VTF 269
G ++GQ C+ATN G S + ++ PP +E V + +
Sbjct: 6333 V-----GKGDSGQ-YTCQATNDV--GKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQL 6384
Query: 270 HCSAKANPAVTQYRWAKRGQIIKEA-------SGEVYRTTVDYTYFSEPVS--CEVTNAL 320
C +P + + W + + E+ V T++ + CE N +
Sbjct: 6385 ECKISGSPEI-KVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGV 6443
Query: 321 GSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE 380
G + S + V P T +P + GSD I C +G P +VW+K V S +
Sbjct: 6444 GDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKK 6503
Query: 381 KTLTLK---------SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP-IISSTQTQHA 430
+T K ++ D G+Y C+A VG+ ++ PP +
Sbjct: 6504 FKITSKHFDTSLHILNLEASDVGEYHCKA-TNEVGSDTCSCSVKFKEPPRFVKKLSDTST 6562
Query: 431 LHGEKGQIKCFIRSTPP 447
L G+ +++ + P
Sbjct: 6563 LIGDAVELRAIVEGFQP 6579
Score = 85.5 bits (210), Expect = 2e-16
Identities = 111/496 (22%), Positives = 185/496 (37%), Gaps = 72/496 (14%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIPEYDGF-VLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
+F +P+ G+ +C + +W KDG AL S P + + +
Sbjct: 3552 TFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAAL------SPSPNWRI--SDAE 3603
Query: 108 GEHHLKILRAELQDDAVYECQA----------IQAAIRSRPARLTVLVPPDDPVILGGPV 157
+H L++ +QD VY C+A + I +P + L P +
Sbjct: 3604 NKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAI------ 3657
Query: 158 ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPG 217
++L C D + ++ W + G+ + K D ++TL I
Sbjct: 3658 -----NKKVHLECQVDEDRKV-TVTWSKDGQKLPPGKDYKICFEDK-----IATLEIPLA 3706
Query: 218 DVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPV-LEDNVVTFHCSAKAN 276
+++ + VC A+N+A G S T+ ++ PP V+P + L HC K +
Sbjct: 3707 KLKDSGTYVCTASNEA--GSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGS 3764
Query: 277 PAVTQYRWAKRGQIIKEA---------SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSR 327
P + Q W K + + E+ S + T S SCE N +GS + S
Sbjct: 3765 PVI-QVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823
Query: 328 TVDVYFGPRM--TTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV------VLSN 379
+ + P T EP ++ G++A+ C +G I W K + L +
Sbjct: 3824 EIVIKEPPSFIKTLEPADIV--RGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFS 3881
Query: 380 EKTLT---LKSVRQEDAGKYVCRAVVPRVG-AGEREVTLTVNGPPIISSTQTQHALHGEK 435
+K+L + S D G+Y C V VG G L P + AL G+
Sbjct: 3882 QKSLVCLEIFSFNSADVGEYEC-VVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQT 3940
Query: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQT 495
++ +R + P +E + E G +S GV + I V+ F
Sbjct: 3941 VTLQAAVRGSEPISVTWMKGQEVIREDGKI------KMSFSNGV--AVLIIPDVQISFGG 3992
Query: 496 IYNCTAWNSFGSDTEI 511
Y C A N GS T +
Sbjct: 3993 KYTCLAENEAGSQTSV 4008
Score = 83.2 bits (204), Expect = 9e-16
Identities = 121/514 (23%), Positives = 197/514 (38%), Gaps = 86/514 (16%)
Query: 52 QQPQDQVVVSGQPVTLLCAIP-EYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
Q+ Q V SG+P I + W K+ L G H E+
Sbjct: 3243 QELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFL--------HDGQEY 3294
Query: 111 HLKILRAELQDDAVYECQAIQA-AIRSRPARLTVLVP----PDDPVILGGPVISL----- 160
L ++ A +D AVY C+A + + A L+V VP PD + + P I
Sbjct: 3295 TLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDT 3354
Query: 161 --RAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSK-TLLRDGKRESIVSTL----- 212
G P C S W K + I + + + T D + I
Sbjct: 3355 VTSEGQPARFQCRVSGTDLKVS--WYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3412
Query: 213 ---FISP---GDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNV 266
F++ G V + ++ A + E + ++++ P++ +EP V ++
Sbjct: 3413 TYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHL 3472
Query: 267 VTFHCSAKANPAVTQYRWAKRGQIIKEA------------SGEVYRTTV----DYTYFSE 310
F C ++ P V +++W K G+ I E+ S E+ RT V +YT
Sbjct: 3473 AKFTCEIQSAPNV-RFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYT---- 3527
Query: 311 PVSCEVTNALGSTNLSRTVDVY--FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVW 368
C+ +N GS + + T+ V + P + P+SL +G A F C TG P + +W
Sbjct: 3528 ---CKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIW 3584
Query: 369 MKRGSGVVLS---------NEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTL-TVNG 418
K G+ + S N+ L L ++ +D G Y C+A + GA + L ++
Sbjct: 3585 QKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKA-SNKFGADICQAELIIIDK 3643
Query: 419 PPIISSTQTQHALHGEKGQIKCFIRSTPPPDR---IAWSWKENVLESGTSGRYTVETIST 475
P I + + +K ++C + DR + WS L G +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQV----DEDRKVTVTWSKDGQKLPPGKDYKICF----- 3694
Query: 476 EEGVISTLTISNIVRADFQTIYNCTAWNSFGSDT 509
E I+TL I D T Y CTA N GS +
Sbjct: 3695 -EDKIATLEIPLAKLKDSGT-YVCTASNEAGSSS 3726
Score = 81.3 bits (199), Expect = 3e-15
Identities = 107/493 (21%), Positives = 202/493 (40%), Gaps = 71/493 (14%)
Query: 59 VVSGQPVTLLCAI---PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHL-------SG 108
V P+TL C + PE V W+KDG + R S + V + SG
Sbjct: 5152 VTEKDPMTLECVVAGTPELK--VKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSG 5209
Query: 109 EHHLKILRAELQDDAVYECQA-IQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLN 167
++ K+ D C A ++ ++ P T + D V+ G ++
Sbjct: 5210 QYTFKVEN----DFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL----------GSSIH 5255
Query: 168 LTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVC 227
+ C + P S W + G+ I+ + + + + V+ L ++E+ + C
Sbjct: 5256 MECKVSGSLPI-SAQWFKDGKEISTSAKYRLVCHERSVSLEVNNL-----ELEDTANYTC 5309
Query: 228 RATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKR 287
+ +N A G S + ++ PP + Q + D+ V F K P + +W K
Sbjct: 5310 KVSNVA--GDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPF-KIKWFKD 5366
Query: 288 GQIIKEASGE-----VYRTTVDYTYFSEPVS------CEVTNALGSTNLSRTVDVYFGPR 336
++ SG + +T +S S C VTN +GS + + + V P+
Sbjct: 5367 D--VELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPK 5424
Query: 337 MTTEPQ-SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLT---------LK 386
+ + S +V G + C G+P + +VW + + S++ +T +
Sbjct: 5425 FVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMN 5484
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISS-TQTQHALHGEKGQIKCFIRST 445
++ ED+G ++C A P G+ + V PP+ SS L + ++C + T
Sbjct: 5485 NLSTEDSGDFICEAQNP-AGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGT 5543
Query: 446 PPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSF 505
PP + + W ++ + +S +Y + + + +++ I N+ +D Y+C A N
Sbjct: 5544 PPFEVV---WYKDKRQLRSSKKYKIAS----KNFHTSIHILNVDTSDIGE-YHCKAQNEV 5595
Query: 506 GSDTEI--IRLKE 516
GSDT + ++LKE
Sbjct: 5596 GSDTCVCTVKLKE 5608
Score = 79.7 bits (195), Expect = 9e-15
Identities = 110/484 (22%), Positives = 191/484 (39%), Gaps = 60/484 (12%)
Query: 52 QQPQDQVVVSGQPVTLLCAI---PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSG 108
++P+ V +G P L C + PE W KD GR+LS+ ++ + ++
Sbjct: 6649 EKPEPMTVTTGNPFALECVVTGTPELS--AKWFKD------GRELSADSKHHI--TFINK 6698
Query: 109 EHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLR-----AG 163
LKI AE+ D +Y + + +S TV V D ++ + L+ G
Sbjct: 6699 VASLKIPCAEMSDKGLYSFEVKNSVGKS---NCTVSVHVSDRIVPPSFIRKLKDVNAILG 6755
Query: 164 DPLNLTCHADNAKPAASIIWLRKG-EVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
+ L C + P S+ W + G E+++G + + V TL +S + +
Sbjct: 6756 ASVVLECRVSGSAP-ISVGWFQDGNEIVSGPKCQSSFSEN------VCTLNLSLLEPSDT 6808
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQY 282
C A N + G E S + +Q PP + + VL +TF + P +
Sbjct: 6809 GIYTCVAAN--VAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPF-KV 6865
Query: 283 RWAKRGQIIK-----EASGEVYRTTVD----YTYFSEPVSCEVTNALGSTNLSRTVDVYF 333
+W K + + S E + T ++ S SC VTN GS + + + V
Sbjct: 6866 KWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKE 6925
Query: 334 GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK---------RGSGVVLSNEKTLT 384
V+ GS + +TG P +++ W+K R S + L
Sbjct: 6926 PATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILE 6985
Query: 385 LKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP-IISSTQTQHALHGEKGQIKCFIR 443
+ ED +Y C + G E ++V PP I + A+ GE ++C +
Sbjct: 6986 ILESTIEDYAQYSC-LIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVD 7044
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
T P RI+W + L S + + + +++L I+ + +D Y+C A N
Sbjct: 7045 GT-PEIRISWYKEHTKLRSAPAYKMQF------KNNVASLVINKVDHSDVGE-YSCKADN 7096
Query: 504 SFGS 507
S G+
Sbjct: 7097 SVGA 7100
Score = 77.4 bits (189), Expect = 5e-14
Identities = 87/376 (23%), Positives = 150/376 (39%), Gaps = 43/376 (11%)
Query: 158 ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPG 217
I G P+ LTC + + P + W R G ++ +T D V+TL I
Sbjct: 6184 IEQTVGLPVTLTCRLNGSAPI-QVCWYRDGVLLRDDENLQTSFVDN-----VATLKILQT 6237
Query: 218 DVENGQSIVCRATNKAIPGGKETSVTIDIQHP---PLVNLSVEPQPVLEDNVVTFHCSAK 274
D+ + C A+N G +S + + P P ++ V+ F C
Sbjct: 6238 DLSHSGQYSCSASNPL--GTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVT 6295
Query: 275 ANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYF----------SEPVSCEVTNALGSTN 324
+ + W+K + I+ G T V T S +C+ TN +G
Sbjct: 6296 GAQPM-RITWSKDNKEIRPG-GNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDM 6353
Query: 325 LSRTVDVYFGPRMTTEPQSLLVDLGSDAI-FSCAWTGNPSLTIVWMKRGSGV-------- 375
S + V P+ + ++ V ++I C +G+P + + W + S +
Sbjct: 6354 CSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNM 6413
Query: 376 -VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQ-HALHG 433
+++ LT+ ED+G Y+C A VG LTV PP+ + + AL G
Sbjct: 6414 SFINSVALLTINEASAEDSGDYICEAH-NGVGDASCSTALTVKAPPVFTQKPSPVGALKG 6472
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADF 493
++C I TPP + + W ++ + S ++ + T + ++L I N+ +D
Sbjct: 6473 SDVILQCEISGTPPFEVV---WVKDRKQVRNSKKFKI----TSKHFDTSLHILNLEASDV 6525
Query: 494 QTIYNCTAWNSFGSDT 509
Y+C A N GSDT
Sbjct: 6526 GE-YHCKATNEVGSDT 6540
Score = 72.8 bits (177), Expect = 1e-12
Identities = 103/460 (22%), Positives = 176/460 (38%), Gaps = 62/460 (13%)
Query: 78 VLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSR 137
VLW KD + ++ S + V + H+L + +D Y C+A AA
Sbjct: 7337 VLWYKDETEI---QESSKFRMSFVDSVAVLEMHNLSV-----EDSGDYTCEAHNAA--GS 7386
Query: 138 PARLTVLVPPDDPVILGGP-VISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYS 196
+ T L + P+ P I G ++L C P + W +
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPF-HVSWYK----------D 7435
Query: 197 KTLLRDGKRESIVSTLFISPGDVENGQSI-----VCRATNKAIPGGKETSV-TIDIQHPP 250
K LR GK+ I+S F++ + N + C+ATN G +T V +I ++ PP
Sbjct: 7436 KRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDV---GSDTCVGSIALKAPP 7492
Query: 251 LVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGE--VYRTTVDYTYF 308
+ + V + + ++ + +G+I++E+ Y + F
Sbjct: 7493 RFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQF 7552
Query: 309 S--EPVS-----CEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGN 361
S EP + C++ N G T+ V + +P+S+ V G C G
Sbjct: 7553 SRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGT 7612
Query: 362 PSLTIVWMKRGSGVVLSNE---------KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREV 412
P L+ W K G + N+ L + +V D+G Y P VG
Sbjct: 7613 PELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNP-VGKDSCTA 7671
Query: 413 TLTVNG----PPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRY 468
+L V+ P + + L G ++C + +PP ++W + N + SG +
Sbjct: 7672 SLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPIS-VSWFHEGNEISSGRKYQT 7730
Query: 469 TVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSD 508
T+ T +T LT++ + +D Y C A N GSD
Sbjct: 7731 TL-TDNT-----CALTVNMLEESD-SGDYTCIATNMAGSD 7763
Score = 70.1 bits (170), Expect = 7e-12
Identities = 106/486 (21%), Positives = 186/486 (38%), Gaps = 57/486 (11%)
Query: 53 QPQDQV-VVSGQPVTLLCAI---PEYDGFVLWIKDGLALGVGRDLSSYPQY-LVVGNHLS 107
+P + V V G+P TL C + PE + W K+ L S P Y + N+++
Sbjct: 7024 EPLEHVEAVIGEPATLQCKVDGTPEIR--ISWYKEHTKL------RSAPAYKMQFKNNVA 7075
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRA--GDP 165
L I + + D Y C+A + + + V+ P + + G P
Sbjct: 7076 S---LVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFP 7132
Query: 166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
+ C + ++P + W + G ++ +T V+TL I D +
Sbjct: 7133 VAFECRINGSEPL-QVSWYKDGVLLKDDANLQTSFVHN-----VATLQILQTDQSHIGQY 7186
Query: 226 VCRATNKAIPGGKETSVTI-DIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
C A+N + + + + PP +L + TF C + + W
Sbjct: 7187 NCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPI-KITW 7245
Query: 285 AKRGQIIKEASGEVYRTTVDYTYF----------SEPVSCEVTNALGSTNLSRTVDVYFG 334
AK + I+ G T V+ T + +C +N G + S + V
Sbjct: 7246 AKDNREIRPG-GNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEP 7304
Query: 335 PRMTTEPQ-SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE---------KTLT 384
PR + + S +V + C G+P + ++W K + + S++ L
Sbjct: 7305 PRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLE 7364
Query: 385 LKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPII-SSTQTQHALHGEKGQIKCFIR 443
+ ++ ED+G Y C A G+ +L V PPI L G ++C ++
Sbjct: 7365 MHNLSVEDSGDYTCEAH-NAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQ 7423
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
TPP ++W + L SG +Y + + E ++++ I N+ AD Y C A N
Sbjct: 7424 GTPP-FHVSWYKDKRELRSGK--KYKIMS----ENFLTSIHILNVDAADIGE-YQCKATN 7475
Query: 504 SFGSDT 509
GSDT
Sbjct: 7476 DVGSDT 7481
Score = 67.8 bits (164), Expect = 4e-11
Identities = 104/436 (23%), Positives = 174/436 (39%), Gaps = 57/436 (13%)
Query: 112 LKILRAELQDDAVYECQAIQAAIRSR-PARLTVLVPPD--DPVILGGPVISLRAGDPLNL 168
L+IL + ++D A Y C A + A ++VL PP +P+ VI G+P L
Sbjct: 6984 LEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVI----GEPATL 7039
Query: 169 TCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
C D P I W ++ + A K ++ V++L I+ D + C+
Sbjct: 7040 QCKVDGT-PEIRISWYKEHTKLRSAPAYKMQFKNN-----VASLVINKVDHSDVGEYSCK 7093
Query: 229 ATNKAIPGGKETSVTIDIQH---PPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWA 285
A N G +S + I+ PP ++ V F C + + Q W
Sbjct: 7094 ADNSV--GAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPL-QVSWY 7150
Query: 286 KRGQIIKE------------ASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV---D 330
K G ++K+ A+ ++ +T D ++ + +C +N LG+ + S + +
Sbjct: 7151 KDGVLLKDDANLQTSFVHNVATLQILQT--DQSHIGQ-YNCSASNPLGTASSSAKLILSE 7207
Query: 331 VYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK-----RGSG----VVLSNEK 381
P +P S+ + LG F C TG + I W K R G ++ N
Sbjct: 7208 HEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTA 7267
Query: 382 TLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP--IISSTQTQHALHGEKGQIK 439
TLT+ V + DAG+Y C A G L V PP I ++ E + +
Sbjct: 7268 TLTVLKVGKGDAGQYTCYA-SNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYE 7326
Query: 440 CFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNC 499
C I +P I W ++ E S ++ + + + ++ L + N+ D Y C
Sbjct: 7327 CKIGGSP---EIKVLWYKDETEIQESSKFRMSFVDS----VAVLEMHNLSVED-SGDYTC 7378
Query: 500 TAWNSFGSDTEIIRLK 515
A N+ GS + LK
Sbjct: 7379 EAHNAAGSASSSTSLK 7394
Score = 64.7 bits (156), Expect = 3e-10
Identities = 114/498 (22%), Positives = 198/498 (39%), Gaps = 57/498 (11%)
Query: 50 FSQQPQDQVVV-SGQPVTLLCAIPEYDGF-VLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
F ++P +V+ +GQ T C I V W DG ++++ ++ + + +
Sbjct: 4863 FIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDG------NEITAIQKHGI--SFID 4914
Query: 108 GEHHLKILRAELQDDAVYECQAIQ-AAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPL 166
G +I A +++ Y C+A A S L V PP L PV ++ D +
Sbjct: 4915 GLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELK-PVEVVKYSD-V 4972
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
L C P + WL+ I + K L D R S+ + L I+ D +
Sbjct: 4973 ELECEVTGTPPF-EVTWLKNNREIRSS--KKYTLTD--RVSVFN-LHITKCDPSDTGEYQ 5026
Query: 227 CRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAK 286
C +N+ G S + ++ PP +E + + TF + +P ++ W K
Sbjct: 5027 CIVSNEG--GSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPIS-ITWLK 5083
Query: 287 RGQIIKEASGEVYRTTVDYTY----------FSEPVSCEVTNALGSTNLSRTVDVYFGPR 336
QI+ E VY + VD S +C+ N G + V +
Sbjct: 5084 DDQILDE-DDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQ 5142
Query: 337 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLS---------NEKTLTLKS 387
+ + +S+ V C G P L + W+K G +V S N + ++S
Sbjct: 5143 IVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQS 5202
Query: 388 VRQEDAGKYVCRAVVPRVGAGEREVTLTV---NGPPIISSTQTQ-HALHGEKGQIKCFIR 443
V ++D+G+Y + V G+ + L V N PP + T+ + G ++C +
Sbjct: 5203 VMKQDSGQYTFK-VENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVS 5261
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
+ P I+ W ++ E TS +Y + + E V +L ++N+ D Y C N
Sbjct: 5262 GSLP---ISAQWFKDGKEISTSAKYRL--VCHERSV--SLEVNNLELEDTAN-YTCKVSN 5313
Query: 504 SFGSD--TEIIRLKEQGS 519
G D + I+ +KE S
Sbjct: 5314 VAGDDACSGILTVKEPPS 5331
Score = 63.5 bits (153), Expect = 7e-10
Identities = 116/495 (23%), Positives = 187/495 (37%), Gaps = 55/495 (11%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIPEYDGF-VLWIKDGLALGV-GRDLSSYPQYLVVGNHL 106
+F ++ D + + GQ VTL A+ + V W+K + G+ S+ + V
Sbjct: 3925 TFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAV---- 3980
Query: 107 SGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPL 166
L I ++ Y C A A S+ + ++V +I +I + AGDP
Sbjct: 3981 -----LIIPDVQISFGGKYTCLAENEA-GSQTSVGELIVKEPAKIIERAELIQVTAGDPA 4034
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
L + P W + G + + R + ++ F S ++GQ
Sbjct: 4035 TLE-YTVAGTPELKPKWYKDGRPL----VASKKYRISFKNNVAQLKFYSAELHDSGQ-YT 4088
Query: 227 CRATNKAIPGGKETSVTI-DIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWA 285
+N+ ET+ T+ D P + + + C A + W
Sbjct: 4089 FEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKI-AGSLPMRVSWF 4147
Query: 286 KRGQIIKEASGEVYRTT-VDYTYFSEPV----------SCEVTNALGSTNLSRTVDVYFG 334
K G+ I A+ + YR V+ T E + +C TN++GS + S + V
Sbjct: 4148 KDGKEI--AASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEP 4205
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSN---------EKTLTL 385
P T+P S V GS + G+ LTI W K +V E +L L
Sbjct: 4206 PSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLEL 4265
Query: 386 KSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP--IISSTQTQHALHGEKGQIKCFIR 443
V+ D+G Y C+ V G E L V P + +Q G+ Q+ C +
Sbjct: 4266 YLVKTSDSGTYTCK-VSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVT 4324
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
TPP I +W N E S ++ + + E + LT I + Y C A N
Sbjct: 4325 GTPP---IKITWFANDREIKESSKHRMSFV--ESTAVLRLTDVGI---EDSGEYMCEAQN 4376
Query: 504 SFGSD--TEIIRLKE 516
GSD + I+ +KE
Sbjct: 4377 EAGSDHCSSIVIVKE 4391
Score = 63.2 bits (152), Expect = 9e-10
Identities = 91/423 (21%), Positives = 156/423 (36%), Gaps = 48/423 (11%)
Query: 112 LKILRAELQDDAVYECQAIQAA-IRSRPARLTVLVPP---DDPVILGGPVISLRAGDPLN 167
L I A +D Y C+A S LTV PP P PV +L+ D +
Sbjct: 6422 LTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKP----SPVGALKGSDVI- 6476
Query: 168 LTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVC 227
L C P ++W++ + + + K + ++ + L + DV C
Sbjct: 6477 LQCEISGTPPF-EVVWVKDRKQVRNS--KKFKITSKHFDTSLHILNLEASDVGEYH---C 6530
Query: 228 RATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKR 287
+ATN+ G S ++ + PP + L + V + ++ R
Sbjct: 6531 KATNEV--GSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDR 6588
Query: 288 GQIIKEASGE--VYRTTVDYTYFSEPVS-------CEVTNALGSTNLSRTVDVYFGPRMT 338
G++I+E+ + + P + C++ N G S + V R+
Sbjct: 6589 GEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARII 6648
Query: 339 TEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV---------VLSNEKTLTLKSVR 389
+P+ + V G+ C TG P L+ W K G + ++ +L +
Sbjct: 6649 EKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAE 6708
Query: 390 QEDAGKYVCRAVVPRVGAGEREVTLTVNG----PPIISSTQTQHALHGEKGQIKCFIRST 445
D G Y V VG V++ V+ P I + +A+ G ++C + S
Sbjct: 6709 MSDKGLYSFE-VKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRV-SG 6766
Query: 446 PPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSF 505
P + W N + SG + S+ + TL +S + +D IY C A N
Sbjct: 6767 SAPISVGWFQDGNEIVSGPKCQ------SSFSENVCTLNLSLLEPSD-TGIYTCVAANVA 6819
Query: 506 GSD 508
GSD
Sbjct: 6820 GSD 6822
Score = 62.4 bits (150), Expect = 2e-09
Identities = 101/434 (23%), Positives = 164/434 (37%), Gaps = 69/434 (15%)
Query: 112 LKILRAELQDDAVYECQAIQ-AAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTC 170
L+ R E + Y CQ A ++ A L+VL P ++ I + GD L C
Sbjct: 7550 LQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPAT--IVEKPESIKVTTGDTCTLEC 7607
Query: 171 HADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGD-------VENGQ 223
P S W + G+ + +K + + S + + ++P D V+N
Sbjct: 7608 TVAGT-PELSTKWFKDGKELTSD--NKYKISFFNKVSGLKIINVAPSDSGVYSFEVQN-- 7662
Query: 224 SIVCRATNKAIPGGKETSVTIDIQH-----PPLVNLSVEPQPVLEDNVVTFHCSAKANPA 278
P GK+ S T +Q PP ++ L + V C +P
Sbjct: 7663 -----------PVGKD-SCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPP 7710
Query: 279 VTQYRWAKRGQIIKEASGEVYRTTV-DYTYF----------SEPVSCEVTNALGSTNLSR 327
++ W G I +SG Y+TT+ D T S +C TN GS S
Sbjct: 7711 IS-VSWFHEGNEI--SSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSA 7767
Query: 328 TVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLK- 386
+ V P +P + V G++ F+ G P ++ W K S +V + ++L+
Sbjct: 7768 PLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLED 7827
Query: 387 --------SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQ- 437
V +G+Y C V G L + P +++ EKG+
Sbjct: 7828 SVAELELFDVDTSQSGEYTC-IVSNEAGKASCTTHLYIKAPAKFVKRLNDYSI--EKGKP 7884
Query: 438 --IKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQT 495
++ TPP I+ +WK+N + S R + T TE+ I + S + A
Sbjct: 7885 LILEGTFTGTPP---ISVTWKKNGINVTPSQRCNITT--TEKSAILEIPSSTVEDAG--- 7936
Query: 496 IYNCTAWNSFGSDT 509
YNC N+ G D+
Sbjct: 7937 QYNCYIENASGKDS 7950
Score = 58.9 bits (141), Expect = 2e-08
Identities = 66/312 (21%), Positives = 111/312 (35%), Gaps = 31/312 (9%)
Query: 109 EHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNL 168
E L++ + D Y C+ A + + P V P L+ GD L
Sbjct: 4260 ESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQL 4319
Query: 169 TCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
C P I W I ++ + + + L ++ +E+ +C
Sbjct: 4320 ACKVTGTPPI-KITWFANDREIKESSKHRMSFVES-----TAVLRLTDVGIEDSGEYMCE 4373
Query: 229 ATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
A N+A G S + ++ P +P VL++ V P + W K
Sbjct: 4374 AQNEA--GSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPF-EITWFKDN 4430
Query: 289 QIIKEASGEVYRTTVDYTYFSEPV-----------SCEVTNALGSTNLSRTVDVYFGPRM 337
I++ SG Y+T + S + C VTN +GS+ S V + P
Sbjct: 4431 TILR--SGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSF 4488
Query: 338 TTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVV---------LSNEKTLTLKSV 388
+ +S G A F G+ +T+ W+K + +N +L L +
Sbjct: 4489 IKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGI 4548
Query: 389 RQEDAGKYVCRA 400
+ GKYVC+A
Sbjct: 4549 EVKHDGKYVCQA 4560
Score = 56.2 bits (134), Expect = 1e-07
Identities = 128/612 (20%), Positives = 216/612 (35%), Gaps = 78/612 (12%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIPEYDGF-VLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
SF+++ ++ +SG V + C + V W +G + GR Q + N +
Sbjct: 7683 SFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKY----QTTLTDNTCA 7738
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIRSR-PARLTVLVPPDDPVILGGPVISLRAGDPL 166
L + E D Y C A A A LTV PP + + + G +
Sbjct: 7739 ----LTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPS--FVQKPDPMDVLTGTNV 7792
Query: 167 NLTCHADNAKPAASIIWLR-KGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI 225
T P S+ W + E++ G + +L E V+ L + D
Sbjct: 7793 TFTSIVKGTPPF-SVSWFKGSSELVPGDRCNVSL------EDSVAELELFDVDTSQSGEY 7845
Query: 226 VCRATNKAIPGGKETSVT-IDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
C +N+A GK + T + I+ P + + + + + P ++ W
Sbjct: 7846 TCIVSNEA---GKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPIS-VTW 7901
Query: 285 AKRGQIIKEASGEVYRTTVDYTYFSEPVS---------CEVTNALGSTNLSRTVDVYFGP 335
K G + + TT P S C + NA G + S + + P
Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPP 7961
Query: 336 RMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV---------VLSNEKTLTLK 386
+ + + V +G A C G P + + W K + + +N TL
Sbjct: 7962 YFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFN 8021
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNG---PPIIS-STQTQHALHGEKGQIKCFI 442
V D+G+Y+C+A VG LTV PP S + G C I
Sbjct: 8022 QVDINDSGEYICKA-ENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAI 8080
Query: 443 RSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTI--YNCT 500
+ P I+ SW ++ G+ ++ + + + NI + D Y+CT
Sbjct: 8081 SGSEP---ISVSWYKD-------GKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130
Query: 501 AWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCC 560
A N GS + RL +E K+ + P+ ++G + F C
Sbjct: 8131 ATNPIGSASSSARLIL--TEGKNPPFFDIRLAPVDAVVGESAD--------------FEC 8174
Query: 561 ARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVL 620
+ V AK+ + K S E H T+ L +D+G+ Q + EV
Sbjct: 8175 HVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTV--LKVDKGDSGQYTCYAVNEVG 8232
Query: 621 KEEEKEFQNLKD 632
K+ N+K+
Sbjct: 8233 KDSCTAQLNIKE 8244
Score = 53.5 bits (127), Expect = 7e-07
Identities = 92/422 (21%), Positives = 152/422 (36%), Gaps = 50/422 (11%)
Query: 80 WIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPA 139
W KDG +++S+ +Y +V + S L++ EL+D A Y C+ A A
Sbjct: 5270 WFKDG------KEISTSAKYRLVCHERSVS--LEVNNLELEDTANYTCKVSNVA--GDDA 5319
Query: 140 RLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKG-EVINGATYSKT 198
+L + P L P D P I W + E+++G
Sbjct: 5320 CSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIG 5379
Query: 199 LLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEP 258
L E S L + D C TN G + + + PP +E
Sbjct: 5380 L------EGSTSFLNLYSVDASKTGQYTCHVTNDV--GSDSCTTMLLVTEPPKFVKKLEA 5431
Query: 259 QPVLE-DNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDY----------TY 307
+++ + C +P + + ++ AS + T +D T
Sbjct: 5432 SKIVKAGDSSRLECKIAGSPEIRVVWFRNEHEL--PASDKYRMTFIDSVAVIQMNNLSTE 5489
Query: 308 FSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIV 367
S CE N GST+ S V V P ++ P + ++ C +G P +V
Sbjct: 5490 DSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVV 5549
Query: 368 WMKRGSGVVLSNEKTLTLK---------SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNG 418
W K + S + + K +V D G+Y C+A VG+ T+ +
Sbjct: 5550 WYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKA-QNEVGSDTCVCTVKLKE 5608
Query: 419 PP-IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSW---KENVLESGTSGRYT-VETI 473
PP +S + + GE +++ I P I W KE V+ + R T VE +
Sbjct: 5609 PPRFVSKLNSLTVVAGEPAELQASIEGAQP---IFVQWLKEKEEVIRESENIRITFVENV 5665
Query: 474 ST 475
+T
Sbjct: 5666 AT 5667
Score = 53.5 bits (127), Expect = 7e-07
Identities = 115/533 (21%), Positives = 192/533 (36%), Gaps = 85/533 (15%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIPEYDGF-VLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
SFS+Q +D G PV CAI + V W KDG + L P V + L
Sbjct: 8058 SFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDG------KPLKDSPN--VQTSFLD 8109
Query: 108 GEHHLKILRAELQDDAVYECQAIQA-AIRSRPARLTVLVPPDDPV--ILGGPVISLRAGD 164
L I + + Y C A S ARL + + P I PV ++ G+
Sbjct: 8110 NTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAV-VGE 8168
Query: 165 PLNLTCHADNAKPAASIIWLRKG-EVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQ 223
+ CH +P + W + E+ +G Y + L + ++ L + GD +GQ
Sbjct: 8169 SADFECHVTGTQPI-KVSWAKDSREIRSGGKYQISYLENSAH---LTVLKVDKGD--SGQ 8222
Query: 224 SIVCRATNKAIPGGKETSVTIDIQH----PPLVNLSVEPQPVLEDNVVTFHCSAKANPAV 279
C A N+ G + ++I+ P E E N + +
Sbjct: 8223 -YTCYAVNEV--GKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPI 8279
Query: 280 TQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV---------------SCEVTNALGSTN 324
T W K I+ S + T+ + + +C+V+N GS
Sbjct: 8280 T-VAWYKNNIEIQPTSN------CEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSAL 8332
Query: 325 LSRTVDVYFGPRMTTEPQSLL---VDLGSDAIFSCAWTGNPSLTIVWMKRGSGV------ 375
+ ++ + + Q L V G SC G+ + I W+K G +
Sbjct: 8333 CTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRC 8392
Query: 376 ---VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH 432
S L L+ V + D+G YVC+A G+ + +T+ P ++ + A+
Sbjct: 8393 SFSFASGTAVLELRDVAKADSGDYVCKA-SNVAGSDTTKSKVTIKDKPAVAPATKKAAVD 8451
Query: 433 G------EKGQIKCFIRST---------PPPDRIAWSWKENVLESGTSGRYTVETISTEE 477
G E I+ ++T P + W+ K + GR + ++
Sbjct: 8452 GRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWT-KGKWRQLNQGGRVFIH----QK 8506
Query: 478 GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAE 530
G + L I + + D +Y C A+N G + L Q E K +E +
Sbjct: 8507 GDEAKLEIRDTTKTD-SGLYRCVAFNEHGEIESNVNL--QVDERKKQEKIEGD 8556
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/434 (22%), Positives = 156/434 (35%), Gaps = 67/434 (15%)
Query: 55 QDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 114
+D V +G+ T C + D V W G L P VV H L +
Sbjct: 12203 KDVTVTAGETATFDCELSYEDIPVEWYLKGKKLE--------PSDKVVPRSEGKVHTLTL 12254
Query: 115 LRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADN 174
+L+D E Q ++ A L V PP V P+ + +
Sbjct: 12255 RDVKLEDAG--EVQLTAKDFKTH-ANLFVKEPP---VEFTKPLEDQTVEEGATAVLECEV 12308
Query: 175 AKPAASIIWLRKG-EVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKA 233
++ A + W + G E++ Y ++ DG+ V L I E+ ++ C A +
Sbjct: 12309 SRENAKVKWFKNGTEILKSKKYE--IVADGR----VRKLVIHDCTPEDIKTYTCDAKDF- 12361
Query: 234 IPGGKETSVTIDIQHP------PLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKR 287
+TS +++ P PL +L V E + F C A + +W K
Sbjct: 12362 -----KTSCNLNVVPPHVEFLRPLTDLQVR-----EKEMARFECELSRENA--KVKWFKD 12409
Query: 288 GQIIKE-------ASGEVYRTTVDYTYFSEPV--SCEVTNALGSTNLSRTVDVYFGPRMT 338
G IK+ + G V ++ + SCEV A S L+ V +
Sbjct: 12410 GAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLT----VLEEEAVF 12465
Query: 339 TEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSN---------EKTLTLKSVR 389
T+ + + +D I P ++W K ++ + ++ L +++
Sbjct: 12466 TKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAH 12525
Query: 390 QEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPD 449
EDAG Y CR R + +V + IS Q L GEK + C I P
Sbjct: 12526 LEDAGNYNCRLPSSRT---DGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFP- 12581
Query: 450 RIAWSWKENVLESG 463
+ W + LESG
Sbjct: 12582 -VQWKRDDKTLESG 12594
Score = 50.8 bits (120), Expect = 5e-06
Identities = 50/196 (25%), Positives = 77/196 (39%), Gaps = 23/196 (11%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK-----------TL 383
P E ++L V S+A C TG+P + W ++G ++ K L
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 30987
Query: 384 TLKSVRQEDAGKYVCRAV-----VPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQI 438
+ SV +DA Y RA V + E EV ++ P + HAL GE I
Sbjct: 30988 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 31047
Query: 439 KCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYN 498
K P P I W ++++++ +G Y V + ++L N V Y
Sbjct: 31048 KIPFSGKPDP-VITWQKGQDLIDN--NGHYQVIVTRS----FTSLVFPNGVERKDAGFYV 31100
Query: 499 CTAWNSFGSDTEIIRL 514
A N FG D + + L
Sbjct: 31101 VCAKNRFGIDQKTVEL 31116
Score = 49.7 bits (117), Expect = 1e-05
Identities = 108/520 (20%), Positives = 186/520 (35%), Gaps = 68/520 (13%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIPEYDGF-VLWIKDGLALGVG-RDLSSYPQYLVVGNHL 106
SF ++ +D + G V L C + V W +DG + G + SS+ + + N
Sbjct: 6742 SFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLN-- 6799
Query: 107 SGEHHLKILRAELQDDAVYECQAIQAAIRSR-PARLTVLVPPDDPVILGGPVISLRAGDP 165
L +L E D +Y C A A A LTV PP + + G
Sbjct: 6800 -----LSLL--EPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDS--VEVLPGMS 6850
Query: 166 LNLTCHADNAKPAASIIWLRKG-EVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
L T P + W + E++ G + + +L E V+ L +
Sbjct: 6851 LTFTS-VIRGTPPFKVKWFKGSRELVPGESCNISL------EDFVTELELFEVQPLESGD 6903
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
C TN A G + + ++ P + V + + + P ++ W
Sbjct: 6904 YSCLVTNDA--GSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPIS-VSW 6960
Query: 285 AKRGQIIKEASG------------EVYRTTV-DYTYFSEPVSCEVTNALGSTNLSRTVDV 331
K +I ++ E+ +T+ DY +S C + N G V V
Sbjct: 6961 IKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYS----CLIENEAGQDICEALVSV 7016
Query: 332 YFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV---------VLSNEKT 382
P + + +G A C G P + I W K + + +N +
Sbjct: 7017 LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVAS 7076
Query: 383 LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNG---PPIIS-STQTQHALHGEKGQI 438
L + V D G+Y C+A VGA L + PP + + H G
Sbjct: 7077 LVINKVDHSDVGEYSCKA-DNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAF 7135
Query: 439 KCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTI-- 496
+C I + P +++W +K+ VL + + + + + I++ D I
Sbjct: 7136 ECRINGSEPL-QVSW-YKDGVL--------LKDDANLQTSFVHNVATLQILQTDQSHIGQ 7185
Query: 497 YNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAV 536
YNC+A N G+ + +L E+ L+ SV +A+
Sbjct: 7186 YNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLAL 7225
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/141 (25%), Positives = 60/141 (42%), Gaps = 16/141 (11%)
Query: 291 IKEASGEVYRTTVDYTYFSEPVSCEVTNA------LGSTNLSRTVDVYFGPRMTTEPQSL 344
++E ++ T + + S E+ +A L + +R + R+ T+P+S+
Sbjct: 32511 VREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSM 32570
Query: 345 LVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLS---------NEKTLTLKSVRQEDAGK 395
V G A FSC G P T+ W+++G + S + T + SV+ D G
Sbjct: 32571 TVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGN 32630
Query: 396 YVCRAVVPRVGAGEREVTLTV 416
Y V G E E TLT+
Sbjct: 32631 YSV-VVENSEGKQEAEFTLTI 32650
Score = 47.4 bits (111), Expect = 5e-05
Identities = 105/484 (21%), Positives = 184/484 (38%), Gaps = 71/484 (14%)
Query: 59 VVSGQPVTLLCAIPEYDG-FVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRA 117
VV+G+P L +I FV W+K+ V R+ S + V N + L+ +A
Sbjct: 5621 VVAGEPAELQASIEGAQPIFVQWLKEKEE--VIRE-SENIRITFVENVAT----LQFAKA 5673
Query: 118 ELQDDAVYECQAIQ-AAIRSRPARLTVLVPPDDPVIL--GGPVISLRAGDPLNLTCHADN 174
E + Y CQ +R A L VL P VI+ GP+ ++ G+ L C
Sbjct: 5674 EPANAGKYICQIKNDGGMRENMATLMVLEPA---VIVEKAGPM-TVTVGETCTLECKVAG 5729
Query: 175 AKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAI 234
P S+ W + G+++ + K + +S+L I + ++ + + N
Sbjct: 5730 T-PELSVEWYKDGKLLTSSQKHKFSFYNK-----ISSLRILSVERQDAGTYTFQVQNNV- 5782
Query: 235 PGGKETSVTIDIQH---PPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQII 291
G + +D+ PP ++ + C + ++ + ++ +I+
Sbjct: 5783 -GKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIV 5841
Query: 292 KEASGEVYRTTVDYTYFSEPV----------------SCEVTNALGSTNLSRTVDVYFGP 335
SG Y+TT FS+ V +C N GS + V P
Sbjct: 5842 ---SGAKYQTT-----FSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPP 5893
Query: 336 RMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK----------TLTL 385
EP+ L V G + F+ G P + W RG+ ++ ++ L L
Sbjct: 5894 SFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWF-RGARELVKGDRCNIYFEDTVAELEL 5952
Query: 386 KSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALH-GEKGQIKCFIRS 444
++ +G+Y C V G L V P + H++ G+ ++
Sbjct: 5953 FNIDISQSGEYTC-VVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTG 6011
Query: 445 TPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNS 504
T P I+ +WK++ TS + + ++TE+ I L I N + D Y+C N
Sbjct: 6012 TLP---ISVTWKKDGFNITTSEKCNI--VTTEKTCI--LEILNSTKRDAGQ-YSCEIENE 6063
Query: 505 FGSD 508
G D
Sbjct: 6064 AGRD 6067
Score = 46.2 bits (108), Expect = 1e-04
Identities = 91/476 (19%), Positives = 165/476 (34%), Gaps = 68/476 (14%)
Query: 49 SFSQQPQDQVVVSGQPVTLLCAIP-EYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107
SF+++ + + G + L C + + + W KD +++S+ +Y +
Sbjct: 4676 SFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDD------QEISASEKYKF--SFHD 4727
Query: 108 GEHHLKILRAELQDDAVYECQAIQAAIRSR-PARLTVLVPPDDPVILGGPVISLRAGDPL 166
L+I + E D Y C A A ++ LTV PP + + +
Sbjct: 4728 NTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPY--FVEKPQSQDVNPNTRV 4785
Query: 167 NLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV 226
L P +I W + + ++ R ++ ++L + + + +
Sbjct: 4786 QLKALVGGTAPM-TIKWFKDNKELHSGA-----ARSVWKDDTSTSLELFAAKATDSGTYI 4839
Query: 227 CRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVL---EDNVVTFHCSAKANPAVTQYR 283
C+ +N G + T+ ++ PP +P PVL TF C P + +
Sbjct: 4840 CQLSNDV--GTATSKATLFVKEPP--QFIKKPSPVLVLRNGQSTTFECQITGTPKI-RVS 4894
Query: 284 WAKRGQIIKEASGE---------VYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFG 334
W G I ++ + S CE N G+ + S + V
Sbjct: 4895 WYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEP 4954
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLT---------L 385
P E + + V SD C TG P + W+K + S + TLT +
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHI 5014
Query: 386 KSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP-IISSTQTQHALHGEKGQIKCFIRS 444
D G+Y C V G+ + + PP I + + + +
Sbjct: 5015 TKCDPSDTGEYQC-IVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAG 5073
Query: 445 TPP--------------PDRIAWSWKENV-------LESGTSGRYTVETISTEEGV 479
+PP D + S+ ++V +++G SGRYT + E GV
Sbjct: 5074 SPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQA-KNESGV 5128
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/242 (21%), Positives = 90/242 (37%), Gaps = 28/242 (11%)
Query: 313 SCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG 372
SCE+ N G V P TE + L +G C G P +T+ W K
Sbjct: 6057 SCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGD 6116
Query: 373 SGV---------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN----GP 419
+ + +N TL V D+G+Y C+A +G + + P
Sbjct: 6117 TKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKA-ENSIGTASSKTVFRIQERQLPP 6175
Query: 420 PIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYT--VETISTEE 477
+ G + C + + P ++ W +++ VL T V+ ++T +
Sbjct: 6176 SFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCW-YRDGVLLRDDENLQTSFVDNVATLK 6233
Query: 478 GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVI 537
+ + L+ S Y+C+A N G+ + RL + E K + + V + VI
Sbjct: 6234 ILQTDLSHSG--------QYSCSASNPLGTASSSARLTAR--EPKKSPFFDIKPVSIDVI 6283
Query: 538 IG 539
G
Sbjct: 6284 AG 6285
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 23/118 (19%)
Query: 324 NLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLS----- 378
+L+ + ++ P ++P+S ++ G + +F+C +G PS I W K + +S
Sbjct: 33123 DLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSI 33182
Query: 379 ----NEKTLTLKSVRQEDAGKYVCRA--------------VVPRVGAGEREVTLTVNG 418
N +L +++ D+GKY +A V+P V REV L +G
Sbjct: 33183 SRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSG 33240
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 24/123 (19%)
Query: 313 SCEVTNALGSTNLSRTVDVYFGPRMTTEP---QSLLVDLGSDAIFSCAWTGNPSLTIVWM 369
SCEVT + + VD P + + Q+ +V G+ A+ G P+ T VW
Sbjct: 28339 SCEVTGTI------KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWS 28392
Query: 370 KRGSGVVLSNE-------KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN----- 417
K S + L + TLT+++ + DAGKY + +G + +T TV
Sbjct: 28393 KPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKY---TLTVENNSGSKSITFTVKVLDTP 28449
Query: 418 GPP 420
GPP
Sbjct: 28450 GPP 28452
Score = 39.7 bits (91), Expect = 0.011
Identities = 72/366 (19%), Positives = 132/366 (36%), Gaps = 42/366 (11%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
F +PQ+ ++ G+ +C+I + V W +D + L S +Y V+ + G+
Sbjct: 12554 FISKPQNLEILEGEKAEFVCSISKESFPVQWKRD------DKTLESGDKYDVIAD---GK 12604
Query: 110 HHLKILR-AELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNL 168
+ +++ A LQD Y + A LTV+ + + + P+ R + +
Sbjct: 12605 KRVLVVKDATLQDMGTY---VVMVGAARAAAHLTVI----EKLRIVVPLKDTRVKEQQEV 12657
Query: 169 TCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
+ + A W R E I ++ L +D +V TL I +++ +
Sbjct: 12658 VFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKD-----LVYTLRIRDAHLDDQANYNVS 12712
Query: 229 ATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG 288
TN K + I + + ++ +E VTF C K N +W K G
Sbjct: 12713 LTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWC--KVNRLNVTLKWTKNG 12770
Query: 289 QIIKEASGEVYRTTVDYTYFSEPVSC-------EVTNALGSTNLSRTVDVYFGPRMTTEP 341
+ + + YR Y + C + A +++ + +
Sbjct: 12771 EEVPFDNRVSYRVD-KYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHL 12829
Query: 342 QSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG----SGVVLSNEK-----TLTLKSVRQED 392
+ V DA+FSC + W + G G EK L +K R +D
Sbjct: 12830 EDQTVTEFDDAVFSCQ-LSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDD 12888
Query: 393 AGKYVC 398
+Y C
Sbjct: 12889 ECEYAC 12894
Score = 38.5 bits (88), Expect = 0.024
Identities = 49/211 (23%), Positives = 80/211 (37%), Gaps = 21/211 (9%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE---------KTLTL 385
P + E + + LG A SC G P I W + G ++ S + TLT+
Sbjct: 30533 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 30592
Query: 386 KSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISS----TQTQHALHGEKGQIKCF 441
+ QED G Y C A VG E L + P + + G ++
Sbjct: 30593 MTEEQEDEGVYTCIA-TNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVM 30651
Query: 442 IRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTA 501
P P + W + +L++ S T+E +TE + L + N+ R Y
Sbjct: 30652 YIGRPVP-AMTWFHGQKLLQN--SENITIE--NTEH--YTHLVMKNVQRKTHAGKYKVQL 30704
Query: 502 WNSFGSDTEIIRLKEQGSEMKSGAGLEAESV 532
N FG+ I+ ++ Q K + E++
Sbjct: 30705 SNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 30735
Score = 35.8 bits (81), Expect = 0.16
Identities = 56/242 (23%), Positives = 87/242 (35%), Gaps = 47/242 (19%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL---------SNEKTLTL 385
P++ E Q + V G A F +G P I W K + E TL L
Sbjct: 3239 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLL 3298
Query: 386 KSVRQEDAGKYVCRA---------------VVPRVGAGEREVTLTVNGPPIISSTQTQHA 430
EDA Y C A VP V + ++E + V P II+ Q
Sbjct: 3299 IEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQE--MPVYPPAIITPLQDTVT 3356
Query: 431 LHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYT----------VETISTEEGVI 480
G+ + +C + T +++W K+ ++ R T E +EG
Sbjct: 3357 SEGQPARFQCRVSGTDL--KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTY 3414
Query: 481 STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLK---EQGSEMKSGAGLEAESVPMAVI 537
T SN V + TA S + I+ + E EMK+ ++ + P+ V
Sbjct: 3415 -TFVASNAVGQ-----VSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVA 3468
Query: 538 IG 539
+G
Sbjct: 3469 LG 3470
Score = 35.4 bits (80), Expect = 0.20
Identities = 63/286 (22%), Positives = 106/286 (37%), Gaps = 39/286 (13%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLS----------NEKTLT 384
P++ QS V GSDA F G P W K G + S N L
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELV 2137
Query: 385 LKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQ-TQHALHGEKGQIKCFIR 443
++ V ED+ + +A + G L V +I+ TQ Q + EK + F
Sbjct: 2138 IRDVTAEDSASIMVKA-INIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFEC 2196
Query: 444 STPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWN 503
T P + W ++ +E +Y + + + +S LTI D Y+C
Sbjct: 2197 ETSEP-FVKVKWYKDGMEVHEGDKYRMHS-DRKVHFLSILTIDTSDAED----YSCVLVE 2250
Query: 504 SFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARS 563
T +L +G+ ++ L+ VP + + C S
Sbjct: 2251 DENVKT-TAKLIVEGAVVEFVKELQDIEVPESYSGELE------------------CIVS 2291
Query: 564 QRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMM-DRGEF 608
N++G ND+ ++ K + R G ++ T+K + D+GE+
Sbjct: 2292 PENIEG-KWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEY 2336
Score = 35.4 bits (80), Expect = 0.20
Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 24/91 (26%)
Query: 346 VDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLS---------NEKTLTLKSVRQEDAGKY 396
V +G + + G P +I W+K G + S N+ TL++K+ ++E GKY
Sbjct: 27575 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKY 27634
Query: 397 -------VCRAVVPRVGAGEREVTLTVNGPP 420
VCR VP +T+ GPP
Sbjct: 27635 TVILDNAVCRIAVP--------ITVITLGPP 27657
Score = 32.3 bits (72), Expect = 1.7
Identities = 75/380 (19%), Positives = 136/380 (35%), Gaps = 71/380 (18%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGE 109
F +DQ V G+ T +C + V+W K+ L R + +S E
Sbjct: 11576 FMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVL-----------ISSE 11624
Query: 110 HHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLR-----AGD 164
K + E+++ + + I+A ++ + + V DP + L D
Sbjct: 11625 G--KTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYF----TVKLHDKTAVEKD 11678
Query: 165 PLNLTCHADNAKPAASIIWLRKG-EVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQ 223
+ L C P + W + G E++ YS + DG R L I D+++
Sbjct: 11679 EITLKCEVSKDVP---VKWFKDGEEIVPSPKYS--IKADGLRR----ILKIKKADLKDKG 11729
Query: 224 SIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVV---TFHCSAKANPAVT 280
VC G +T + ++ L +P+ V T H + +
Sbjct: 11730 EYVCDC------GTDKTKANVTVE----ARLIKVEKPLYGVEVFVGETAHFEIELSEPDV 11779
Query: 281 QYRWAKRGQ---------IIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLS-RTVD 330
+W +GQ II++ + + VS + NA + NL + +
Sbjct: 11780 HGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELP 11839
Query: 331 VYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEK--------- 381
+ F T + V +A F C + P T W+K G+ + +++
Sbjct: 11840 LIF----ITPLSDVKVFEKDEAKFECEVSREPK-TFRWLK-GTQEITGDDRFELIKDGTK 11893
Query: 382 -TLTLKSVRQEDAGKYVCRA 400
++ +KS ED KY+ A
Sbjct: 11894 HSMVIKSAAFEDEAKYMFEA 11913
Score = 32.3 bits (72), Expect = 1.7
Identities = 28/76 (36%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 433 GEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSG-RYTVETISTEEGVISTLTISNIVRA 491
GE I + P P +I WS E V+E T + T E +S E + L+I VR
Sbjct: 15413 GEPVHIPADVTGLPMP-KIEWSKNETVIEKPTDALQITKEEVSRSEAK-TELSIPKAVRE 15470
Query: 492 DFQTIYNCTAWNSFGS 507
D T Y TA N GS
Sbjct: 15471 DKGT-YTVTASNRLGS 15485
Score = 32.0 bits (71), Expect = 2.3
Identities = 68/332 (20%), Positives = 123/332 (37%), Gaps = 33/332 (9%)
Query: 150 PVILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVIN-GATYSKTLLRDGKRESI 208
PVI+ G + + D + +P + IW + G+ I G Y + + G I
Sbjct: 32852 PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEI 32911
Query: 209 VSTLFISPG----DVENGQSIV---CRATNKAIPGGKETSVT------IDIQHPPLVNLS 255
T G V+N V C+ T KAI + V+ I Q +V
Sbjct: 32912 HKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEE 32971
Query: 256 VEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCE 315
+ + + + + K + A +Q + A + + K E + + + V E
Sbjct: 32972 ISQKALRSEEI-------KMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEE 33024
Query: 316 VTNALGSTNLSRT---VDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG 372
+T ++ RT + + E Q L++ W N + + +
Sbjct: 33025 ITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLN-GVELTNSEEY 33083
Query: 373 SGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTV-----NGPPIISSTQT 427
V +++TLT+K D G C + + G + + LT+ + P IS ++
Sbjct: 33084 RYGVSGSDQTLTIKQASHRDEGILTCISKT-KEGIVKCQYDLTLSKELSDAPAFISQPRS 33142
Query: 428 QHALHGEKGQIKCFIRSTPPPDRIAWSWKENV 459
Q+ G+ C I P P+ I W +K N+
Sbjct: 33143 QNINEGQNVLFTCEISGEPSPE-IEW-FKNNL 33172
Score = 32.0 bits (71), Expect = 2.3
Identities = 17/73 (23%), Positives = 31/73 (42%), Gaps = 11/73 (15%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE-----------KTL 383
P++ P + +D G +CA+TG P+ + W G + + TL
Sbjct: 33329 PKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTL 33388
Query: 384 TLKSVRQEDAGKY 396
+ V+++D G Y
Sbjct: 33389 IIMDVQKQDGGLY 33401
Score = 31.2 bits (69), Expect = 3.8
Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 9/76 (11%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKS------V 388
P + + +++ V G C +G PS T+ W + + S + +T +S +
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMI 1002
Query: 389 RQ---EDAGKYVCRAV 401
R+ ED+G++ C AV
Sbjct: 1003 REAFAEDSGRFTCSAV 1018
Score = 31.2 bits (69), Expect = 3.8
Identities = 27/102 (26%), Positives = 39/102 (38%), Gaps = 11/102 (10%)
Query: 330 DVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNE--------- 380
D+ P + S V +G D +G P TI W K G + +
Sbjct: 23225 DLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDL 23284
Query: 381 KTLTLKSVRQEDAGKY--VCRAVVPRVGAGEREVTLTVNGPP 420
TL++K ++D G+Y VV + A VTL PP
Sbjct: 23285 TTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPP 23326
Score = 30.8 bits (68), Expect = 5.0
Identities = 49/234 (20%), Positives = 87/234 (37%), Gaps = 38/234 (16%)
Query: 182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETS 241
+WL+ G I + K +++ GK ++ + E + VC G + S
Sbjct: 2913 MWLKNGVEIEMSEKFKIVVQ-GKLHQLIIMNTSTEDSAE--YTFVC--------GNDQVS 2961
Query: 242 VTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRT 301
T+ + P ++ ++ E + +TF + N Y+W K G IK RT
Sbjct: 2962 ATLTVT-PIMITSMLKDINAEEKDTITFEVTV--NYEGISYKWLKNGVEIKSTDKCQMRT 3018
Query: 302 -------TVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPR---MTTEPQSLLVDLGSD 351
+ +F + + + T G + T +Y R + + V
Sbjct: 3019 KKLTHSLNIRNVHFGD--AADYTFVAGKA--TSTATLYVEARHIEFRKHIKDIKVLEKKR 3074
Query: 352 AIFSCAWTGNPSLTIVWMKRGSGVVLSNE---------KTLTLKSVRQEDAGKY 396
A+F C P +T+ WMK + +++ L + S R DAGKY
Sbjct: 3075 AMFECE-VSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKY 3127
Score = 30.8 bits (68), Expect = 5.0
Identities = 29/104 (27%), Positives = 42/104 (40%), Gaps = 16/104 (15%)
Query: 343 SLLVDLGSDAIFSCAWTGNPSLTIVWMK----RGSGVVLSNEKT-----LTLKSVRQEDA 393
S++ G D + G P T+ W K GS S E T LT+ V + D
Sbjct: 27280 SVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDT 27339
Query: 394 GKYVCRAVVPRVGAGE-REVTLTV---NGPPIISSTQTQHALHG 433
GKY+ + G GE + T++V + P Q +H G
Sbjct: 27340 GKYI---LTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRG 27380
Score = 30.8 bits (68), Expect = 5.0
Identities = 24/98 (24%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 163 GDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
G+ +C D +P ++ WLRKG+V+ +T ++ + K +S + D E
Sbjct: 32575 GESARFSCDTDG-EPVPTVTWLRKGQVL--STSARHQVTTTKYKSTFEISSVQASD-EGN 32630
Query: 223 QSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQP 260
S+V + G +E T+ IQ + +V P
Sbjct: 32631 YSVVVENSE----GKQEAEFTLTIQKARVTEKAVTSPP 32664
Score = 30.0 bits (66), Expect = 8.6
Identities = 51/254 (20%), Positives = 94/254 (37%), Gaps = 35/254 (13%)
Query: 256 VEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV-SC 314
+E Q VL+DN F K N + W K + ++ + + + ++D + V +C
Sbjct: 8662 IENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPS--DKFEISIDGDRHTLRVKNC 8719
Query: 315 EVTNALGSTNLSRTVDVYFGPRMTTEP------QSLLVDLGSDAIFSCAWTGNPSLTIVW 368
++ + G+ L + EP Q + + G +C ++ P++ W
Sbjct: 8720 QLKDQ-GNYRLVCGPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMTCQFSV-PNVKSEW 8777
Query: 369 MKRGSGV---------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP 419
+ G + V LT+ VR ED G+Y C + E L +
Sbjct: 8778 FRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTC-----KYEDLETSAELRIEAE 8832
Query: 420 PIISSTQTQHALHGE--KGQIKC-------FIRSTPPPDRIAWSWKENVLESGTSGRYTV 470
PI + + Q+ + E +C + P + S K N G T+
Sbjct: 8833 PIQFTKRIQNIVVSEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTI 8892
Query: 471 ETIS-TEEGVISTL 483
++ +EGV S +
Sbjct: 8893 HNVTPDDEGVYSVI 8906
Score = 30.0 bits (66), Expect = 8.6
Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 17/91 (18%)
Query: 344 LLVDLGSDAIFSCAWTGNPSLTIVWMKRGS------GVVLSNEK---TLTLKSVRQEDAG 394
L V G++ G P T+ W K G+ G+ ++ ++ TL L SV ++D+G
Sbjct: 19305 LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSG 19364
Query: 395 KYVCRAVVPRVGAGEREVTLTVN-----GPP 420
Y + +G + T+ + GPP
Sbjct: 19365 DY---TITAENSSGSKSATIKLKVLDKPGPP 19392
Score = 30.0 bits (66), Expect = 8.6
Identities = 44/196 (22%), Positives = 72/196 (36%), Gaps = 32/196 (16%)
Query: 330 DVYFGPRMTTEP---QSLLVDLGSDAIFSC-AWTGNPSLTIVWMKRGSGVVLSN------ 379
D Y P + +P L + G + + + G P W K G + S+
Sbjct: 20371 DEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITS 20430
Query: 380 ---EKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTV------NGPPIISSTQTQHA 430
LT+K ++DAG+Y A P G V +TV GP IS+ +
Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNP-FGTKVEHVKVTVLDVPGPPGPVEISNVSAE-- 20487
Query: 431 LHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVR 490
K + TPP + K +LE + R +S E + S ++ +
Sbjct: 20488 --------KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVS--EDIQSCRHVATKLI 20537
Query: 491 ADFQTIYNCTAWNSFG 506
+ I+ +A N +G
Sbjct: 20538 QGNEYIFRVSAVNHYG 20553
Score = 30.0 bits (66), Expect = 8.6
Identities = 45/186 (24%), Positives = 64/186 (34%), Gaps = 47/186 (25%)
Query: 349 GSDAIFSCAWTGNPSLTIVWMK---------RGSGVVLSNEKTLTLKSVRQEDAGKYVCR 399
G D + G P+ + W K R + N LT+K +ED G YV +
Sbjct: 22162 GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVK 22221
Query: 400 AVVPRVGAGEREVTLTV-----NGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWS 454
AGE TL V GPP G +K D I S
Sbjct: 22222 LT---NSAGEAIETLNVIVLDKPGPP--------------TGPVK---MDEVTADSITLS 22261
Query: 455 WKENVLESGTS-GRYTVE---TISTEEGVISTLTISNIVRA-------DFQTIYNCTAWN 503
W + G+S Y VE T +T ++S ++A ++Q + A N
Sbjct: 22262 WGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQ--FRIAAEN 22319
Query: 504 SFGSDT 509
+G T
Sbjct: 22320 RYGKST 22325
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 92.0 bits (227), Expect = 2e-18
Identities = 93/367 (25%), Positives = 158/367 (43%), Gaps = 39/367 (10%)
Query: 63 QPVTLLCAIPEYDGFVLWIKDGLA-LGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQD 121
QP+ + C++ F L ++ G A LG R SG +ILRA +
Sbjct: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQE-----------SGNSSWEILRASKAE 489
Query: 122 DAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASI 181
+ YEC A+ A R A+ ++V P ++ P +++ G+ L+C P ++
Sbjct: 490 EGTYECTAVSRAGTGR-AKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY-NL 547
Query: 182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETS 241
W+R V+ +T L D +L IS +G C A+N G S
Sbjct: 548 TWVRDWRVLPASTGRVAQLAD-------LSLEISGIIPTDGGRYQCVASNAN--GVTRAS 598
Query: 242 VTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG---EV 298
V + ++ P V++ Q + V CSA P W++ Q ++E S +
Sbjct: 599 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPT-PHISWSRESQALQEDSRIHVDA 657
Query: 299 YRTTVDYTYFSEPV---SCEVTNALGSTNLSRTVDVYF--GPRMTTEPQSLLVDLGSDAI 353
T + E SC+ TN +G+ TV +Y+ P ++ +LV +G +A+
Sbjct: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTD--QETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
Query: 354 FSCAWTGNPSLTIVWMKRGSGVVLSNEKT----LTLKSVRQEDAGKYVCRAVVPRVGAGE 409
C +G P ++W + G ++L+ E + L + + ++ DAG Y CRA V +G
Sbjct: 716 LVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA-VNELGDAS 774
Query: 410 REVTLTV 416
E+ L V
Sbjct: 775 AEIQLAV 781
Score = 49.7 bits (117), Expect = 1e-05
Identities = 48/209 (22%), Positives = 75/209 (35%), Gaps = 20/209 (9%)
Query: 314 CEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGS 373
C + G+ + V P ++ V G A+ SC G + W++
Sbjct: 495 CTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR 554
Query: 374 GVVLSNEKTLTLKSVRQE-------DAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS-ST 425
+ S + L + E D G+Y C A G V L V P +S T
Sbjct: 555 VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN-GVTRASVWLLVREAPQVSIHT 613
Query: 426 QTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTI 485
+QH G + ++ C P P I+WS + L+ + + TL I
Sbjct: 614 SSQHFSQGVEVKVSCSASGYPTP-HISWSRESQALQEDSRIHVDAQ---------GTLII 663
Query: 486 SNIVRADFQTIYNCTAWNSFGSDTEIIRL 514
+ D Y+C A N G+D E + L
Sbjct: 664 QGVAPEDAGN-YSCQATNEVGTDQETVTL 691
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 89.0 bits (219), Expect = 2e-17
Identities = 103/442 (23%), Positives = 173/442 (39%), Gaps = 60/442 (13%)
Query: 111 HLKILRAELQDDAVYECQAIQAAIRSR-PARLTVLVPPDDPVILGGPVISLRAGDPLNLT 169
H+ + +++D VY C A + AR+ V PP + I+ AG +
Sbjct: 529 HMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN---ITAVAGRDTLIN 585
Query: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS---IV 226
C P SI W + LL D R+ + + DV+ G +
Sbjct: 586 CRVIGY-PYYSIKWYKDA----------LLLPDNHRQVVFENGTLKLTDVQKGMDEGEYL 634
Query: 227 CRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAK 286
C + + SV + ++ PPL+ E P ++ C + + W K
Sbjct: 635 CSVLIQPQLSISQ-SVHVAVKVPPLIQ-PFEFPPASIGQLLYIPCVVSSGDMPIRITWRK 692
Query: 287 RGQIIKEASGEVYRTTVDYTYFSEPV-------------SCEVTNALGSTNLSRTVDVYF 333
GQ+I SG T++ F + +C +NA + + R + V
Sbjct: 693 DGQVIISGSG----VTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 748
Query: 334 GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWM-KRGSG-------------VVLSN 379
PR +P + G + +C+ G P ++W +GSG + +
Sbjct: 749 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP 808
Query: 380 EKTLTLKSVRQEDAGKYVCRAVVPRVGAG---EREVTLTVNGPPIISS-TQTQHALHGEK 435
+L ++ V +ED G Y+C+A G G + + LTV P +I+S T A+ G
Sbjct: 809 NSSLLIRHVLEEDIGYYLCQA---SNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHA 865
Query: 436 GQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQT 495
++ C R P I W + V++ RY + T + V+STL + R D
Sbjct: 866 KELNCTARG-ERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD-SV 923
Query: 496 IYNCTAWNSFGSDTEIIRLKEQ 517
++C A NS+G D +I+L Q
Sbjct: 924 FFSCHAINSYGEDRGLIQLTVQ 945
Score = 87.0 bits (214), Expect = 6e-17
Identities = 84/299 (28%), Positives = 124/299 (41%), Gaps = 24/299 (8%)
Query: 237 GKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG 296
G SVT + P + Q V + V C+A P + RW K G+ + S
Sbjct: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYP-IPAIRWLKDGRPLPADSR 331
Query: 297 EVYRTT----VDY-TYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSD 351
R T D T S CEVTN GS + + V +T P+ L +GS
Sbjct: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGST 391
Query: 352 AIFSCAWTGNPSLTIVWMKRGSGVV---------LSNEKTLTLKSVRQEDAGKYVCRAVV 402
I SCA TG+P TI W + V+ LSNE TL + S ++ +G Y C A
Sbjct: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE-TLLITSAQKSHSGAYQCFATR 450
Query: 403 PRVGAGEREVTLTVNGPP-IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLE 461
A + + +G P I+SS + GE+ + C + PPP + W+ + +
Sbjct: 451 KAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPP-TVTWALDDEPIV 509
Query: 462 SGTSGRYTVETISTEEGVISTLTISNIVRADFQT--IYNCTAWNSFGSDTEIIRLKEQG 518
S R T+S +T++ N+ + +Y CTA N GS R+ +G
Sbjct: 510 RDGSHRTNQYTMSDG----TTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG 564
Score = 71.2 bits (173), Expect = 3e-12
Identities = 110/470 (23%), Positives = 180/470 (38%), Gaps = 52/470 (11%)
Query: 57 QVVVSGQPVTLLCAIPEYD-GFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKIL 115
Q V +G V L C Y + W+KDG L + L + + L
Sbjct: 295 QEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISD----------L 344
Query: 116 RAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNA 175
R E D Y C+ + + +++ P V L + G + L+C A
Sbjct: 345 RTE--DSGTYICEVTNTFGSAEATGILMVIDPLH-VTLTPKKLKTGIGSTVILSC-ALTG 400
Query: 176 KPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIP 235
P +I W R E++ +R E TL I+ + + C AT KA
Sbjct: 401 SPEFTIRWYRNTELV--LPDEAISIRGLSNE----TLLITSAQKSHSGAYQCFATRKAQT 454
Query: 236 GGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQ-IIKEA 294
+ ++ P +V+ S + V + C+AK P T WA + I+++
Sbjct: 455 AQDFAIIALEDGTPRIVS-SFSEKVVNPGEQFSLMCAAKGAPPPT-VTWALDDEPIVRDG 512
Query: 295 SGEVYR------TTVDYTYFSEP-------VSCEVTNALGSTNLSRTVDVYFGPRMTTEP 341
S + TT+ + + P C N +GS ++V GP
Sbjct: 513 SHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR-GPPSIRAM 571
Query: 342 QSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV------VLSNEKTLTLKSVRQE-DAG 394
+++ G D + +C G P +I W K + V+ TL L V++ D G
Sbjct: 572 RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEG 631
Query: 395 KYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWS 454
+Y+C ++ + + V + V PP+I + A G+ I C + S P RI W
Sbjct: 632 EYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
Query: 455 WKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNS 504
V+ SG+ TI ++E +S+L IS+ V Y C A N+
Sbjct: 692 KDGQVIISGSG-----VTIESKE-FMSSLQISS-VSLKHNGNYTCIASNA 734
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 87.0 bits (214), Expect = 6e-17
Identities = 109/451 (24%), Positives = 170/451 (37%), Gaps = 56/451 (12%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+ P D +V G+P TL C A + W K G + +D + L+ L
Sbjct: 33 EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL---F 89
Query: 111 HLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGD 164
L+I+ R D+ VY C A + A+ S A L V + DD P + + G+
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDD--FRQNPSDVMVAVGE 146
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P + C P +I W + G ++ + +R GK L I+ +
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRGGK-------LMITYTRKSDAGK 198
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
VC TN E + ++ P V ++D+ F C A+ +P T RW
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA-EFKCEARGDPVPT-VRW 256
Query: 285 AKR-GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDVYFGP 335
K G++ K Y D+T V+ C N +G S T+ V P
Sbjct: 257 RKDDGELPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
Query: 336 RMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------SNEK 381
+P+ +V LG F C TGNP I W + GS +L S
Sbjct: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 382 TLTLKSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPIISSTQTQHALHGEKG 436
LT+ +V++ D G Y+C+ + + EVT + PP+I + +
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
Query: 437 QIKCFIRSTPPPDRIAWSWKENVLESGTSGR 467
+ + + P I W K+ VL S R
Sbjct: 433 FVLSCVATGSPVPTILWR-KDGVLVSTQDSR 462
Score = 71.6 bits (174), Expect = 3e-12
Identities = 114/500 (22%), Positives = 186/500 (37%), Gaps = 103/500 (20%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDG---------LALGVGRDLSSYP- 97
F Q P D +V G+P + C P + + W KDG + + G+ + +Y
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTR 192
Query: 98 -----QYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVI 152
+Y+ VG ++ GE +E+ + V E + + RP+ L V V
Sbjct: 193 KSDAGKYVCVGTNMVGER-----ESEVAELTVLE----RPSFVKRPSNLAVTV------- 236
Query: 153 LGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTL 212
D C A P ++ W + + + Y +RD + +
Sbjct: 237 ----------DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSRYE---IRD---DHTLKIR 279
Query: 213 FISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCS 272
++ GD+ S C A N + G E S T+ +Q PP + Q V VTF C
Sbjct: 280 KVTAGDM---GSYTCVAEN--MVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 334
Query: 273 AKANPAVTQYRWAKRG--------QIIKEASGEVYRTTVDYTYFSEPVS------CEVTN 318
A NP + W + G Q + +S T D T + S C+ N
Sbjct: 335 ATGNPQPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 393
Query: 319 ALGSTNLSRTVDVYF------GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG 372
GS ++V P + P + V + + SC TG+P TI+W K
Sbjct: 394 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK-- 451
Query: 373 SGVVLSNEKT---------LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN----GP 419
GV++S + + L ++ + D G+Y C A P +GE + + G
Sbjct: 452 DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP---SGEATWSAYIEVQEFGV 508
Query: 420 PIISSTQTQHAL---HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTE 476
P+ T L K ++ R+T + SW+ N+ T Y +E S
Sbjct: 509 PVQPPRPTDPNLIPSAPSKPEVTDVSRNT-----VTLSWQPNLNSGATPTSYIIEAFSHA 563
Query: 477 EGVISTLTISNIVRADFQTI 496
G S T++ V+ + I
Sbjct: 564 SG-SSWQTVAENVKTETSAI 582
Score = 36.6 bits (83), Expect = 0.092
Identities = 17/43 (39%), Positives = 21/43 (48%)
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
F PR+ P L+V G A +C G P+ TI W K G V
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 69
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 87.0 bits (214), Expect = 6e-17
Identities = 98/368 (26%), Positives = 154/368 (41%), Gaps = 46/368 (12%)
Query: 162 AGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSK-TLLRDGKRESIVSTLFISPGDVE 220
+G+ + TC A+ P IIWLR ++ T S+ LL DG TL I
Sbjct: 259 SGNTVYFTCRAEG-NPKPEIIWLRNNNELSMKTDSRLNLLDDG-------TLMIQNTQET 310
Query: 221 NGQSIVCRATNKAIPGGKETSVTIDIQH---PPLVNLSVEPQ--PVLEDNVVTFHCSAKA 275
+ C A N A G+ + + +++ P ++PQ VL VT CSA
Sbjct: 311 DQGIYQCMAKNVA---GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATG 367
Query: 276 NPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV-------SCEVTNALGSTNLSRT 328
+P + W + + V T Y V +C TN + S + +
Sbjct: 368 HPP-PRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAF 426
Query: 329 VDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV------VLSNEKT 382
+ V P+ T PQ +V G F C GNP I W K GS + ++ + T
Sbjct: 427 IIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT 486
Query: 383 LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNG--PPIISSTQTQHALH-GEKGQIK 439
L + V D G+Y C+A V +G+ + LTV P+ +S + + G Q+
Sbjct: 487 LRISGVALHDQGQYECQA-VNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLP 545
Query: 440 CFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNC 499
C + P P A +W ++ ++ SG++ + + EG LTI+++ AD Y C
Sbjct: 546 CSSQGEPEP---AITWNKDGVQVTESGKFHI----SPEGF---LTINDVGPADAGR-YEC 594
Query: 500 TAWNSFGS 507
A N+ GS
Sbjct: 595 VARNTIGS 602
Score = 67.8 bits (164), Expect = 4e-11
Identities = 56/187 (29%), Positives = 81/187 (43%), Gaps = 26/187 (13%)
Query: 335 PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVW--------MKRGSGVVLSNEKTLTLK 386
PR+T+EPQ V G+ F+C GNP I+W MK S + L ++ TL ++
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
Query: 387 SVRQEDAGKYVCRAVVPRVGAGEREVTLTVNG----PPIISSTQTQHALHGEKGQIKCFI 442
+ ++ D G Y C A +EVTL G P + Q L GE ++C
Sbjct: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
Query: 443 RSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVIST--LTISNIVRADFQTIYNCT 500
PPP RI+W T G T + + + L I N+V+ D Y C+
Sbjct: 366 TGHPPP-RISW----------TRGDRTPLPVDPRVNITPSGGLYIQNVVQGD-SGEYACS 413
Query: 501 AWNSFGS 507
A N+ S
Sbjct: 414 ATNNIDS 420
Score = 58.9 bits (141), Expect = 2e-08
Identities = 71/319 (22%), Positives = 114/319 (35%), Gaps = 35/319 (10%)
Query: 221 NGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQP--VLEDNVVTFHCSAKANPA 278
N Q+ + I G ++T + + ++ EPQ V N V F C A+ NP
Sbjct: 215 NAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPK 274
Query: 279 VTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV--------SCEVTNALGSTNLSRTVD 330
+ W + + + D T + C N G
Sbjct: 275 -PEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTL 333
Query: 331 VYFG----PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKR-------GSGVVLSN 379
YFG P +PQ+ V +G C+ TG+P I W + V ++
Sbjct: 334 RYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITP 393
Query: 380 EKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISST-QTQHALHGEKGQI 438
L +++V Q D+G+Y C A + + + V P + T Q + + G+
Sbjct: 394 SGGLYIQNVVQGDSGEYACSA-TNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDF 452
Query: 439 KCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYN 498
+C + PPP +W + + R+ V + TL IS + D Q Y
Sbjct: 453 QCEAKGNPPP---VIAWTKGGSQLSVDRRHLVLS-------SGTLRISGVALHD-QGQYE 501
Query: 499 CTAWNSFGSDTEIIRLKEQ 517
C A N GS + L Q
Sbjct: 502 CQAVNIIGSQKVVAHLTVQ 520
Score = 45.1 bits (105), Expect = 3e-04
Identities = 39/140 (27%), Positives = 58/140 (41%), Gaps = 14/140 (10%)
Query: 50 FSQQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSG 108
F+ PQD+VV+ GQ V C A + W K G L V R ++LV+ +
Sbjct: 435 FTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR------RHLVLSSGT-- 486
Query: 109 EHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGDPLN 167
L+I L D YECQA+ + + P PV P ++ G +
Sbjct: 487 ---LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQ 543
Query: 168 LTCHADNAKPAASIIWLRKG 187
L C + +P +I W + G
Sbjct: 544 LPC-SSQGEPEPAITWNKDG 562
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 87.0 bits (214), Expect = 6e-17
Identities = 133/525 (25%), Positives = 207/525 (39%), Gaps = 67/525 (12%)
Query: 33 YMAKDKFRRMNEGQVYSFSQQPQ------DQVVVSGQPVTLLCAIPEYD-GFVLWIKDGL 85
++ KDK + QV P+ ++VV +PV+L+C + + W D
Sbjct: 386 FVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDD 445
Query: 86 ALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAA-IRSRPARLTVL 144
+ G GN +S +L I ++++D VY C A +A + AR+ V
Sbjct: 446 PILKGGSHRISQMITSEGNVVS---YLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR 502
Query: 145 VPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGK 204
P I I+ AG + C P SI W + ++ +G
Sbjct: 503 GPAS---IRPMKNITAIAGRDTYIHCRVIGY-PYYSIKWYKNSNLLPFNHRQVAFENNG- 557
Query: 205 RESIVSTLFISP--GDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVL 262
TL +S +V+ G+ + + VT+ + PP + P+ +
Sbjct: 558 ------TLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV--PPFIQPFEFPRFSI 609
Query: 263 EDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV---------- 312
V C + W K G+ I + G T+D F+ +
Sbjct: 610 GQRVF-IPCVVVSGDLPITITWQKDGRPIPGSLG----VTIDNIDFTSSLRISNLSLMHN 664
Query: 313 ---SCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVW- 368
+C N + + V P+ +P+ G I +C+ G P TIVW
Sbjct: 665 GNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724
Query: 369 MKRGSGV-------------VLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAG-EREVTL 414
+G+GV VLSN +L +K V +ED+G Y+C+ V VGA + + L
Sbjct: 725 FSKGAGVPQFQPIALNGRIQVLSNG-SLLIKHVVEEDSGYYLCK-VSNDVGADVSKSMYL 782
Query: 415 TVNGPPIISS-TQTQHALHGEKGQIKCFIRSTPPPDRIAWSW-KENVLESGTSGRYTVET 472
TV P +I+S T A G+K ++ C P I W KE+ + + RY V T
Sbjct: 783 TVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKP---IIVRWEKEDRIINPEMARYLVST 839
Query: 473 ISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQ 517
E VISTL I VR D ++C A NS+G D II+L Q
Sbjct: 840 KEVGEEVISTLQILPTVRED-SGFFSCHAINSYGEDRGIIQLTVQ 883
Score = 70.9 bits (172), Expect = 4e-12
Identities = 67/255 (26%), Positives = 107/255 (41%), Gaps = 20/255 (7%)
Query: 267 VTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVS------CEVTNAL 320
V C A +P YRW K + E SG +T + S CEV+N
Sbjct: 242 VELPCKALGHPE-PDYRWLKDNMPL-ELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRY 299
Query: 321 GSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGS------- 373
G+ + + V + T P+ + +GS SC+ TG + W + G
Sbjct: 300 GTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN 359
Query: 374 -GVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGER-EVTLTVNGPPIISSTQTQHAL 431
+ N + L + + + D G Y C ++ A + +V L P IIS+ +
Sbjct: 360 VRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVS 419
Query: 432 HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRA 491
E + C ++ TP P I W+ ++ + G S R + + I++E V+S L IS+
Sbjct: 420 PAEPVSLMCNVKGTPLP-TITWTLDDDPILKGGSHRIS-QMITSEGNVVSYLNISSSQVR 477
Query: 492 DFQTIYNCTAWNSFG 506
D +Y CTA NS G
Sbjct: 478 D-GGVYRCTANNSAG 491
Score = 61.2 bits (147), Expect = 3e-09
Identities = 101/453 (22%), Positives = 161/453 (35%), Gaps = 54/453 (11%)
Query: 60 VSGQPVTLLCAI---PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILR 116
++GQ V L C PE D W+KD + L +LS Q V G L I
Sbjct: 237 MAGQRVELPCKALGHPEPD--YRWLKDNMPL----ELSGRFQKTVTG--------LLIEN 282
Query: 117 AELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAK 176
D Y C+ ++ + P I V S G ++L+C +
Sbjct: 283 IRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS-SVGSQVSLSCSVTGTE 341
Query: 177 PAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPG 236
+ W R GE++N + E+++ + +G + C +
Sbjct: 342 DQ-ELSWYRNGEILNPG--KNVRITGINHENLIMDHMVK----SDGGAYQCFVRKDKLSA 394
Query: 237 GKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASG 296
V ++ P +++ E + V V+ C+ K P T I+K S
Sbjct: 395 QDYVQVVLEDGTPKIISAFSE-KVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSH 453
Query: 297 EVYR------TTVDYTYFSEP-------VSCEVTNALGSTNLSRTVDVYFGPRMTTEPQS 343
+ + V Y S C N+ G ++V GP ++
Sbjct: 454 RISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRPMKN 512
Query: 344 LLVDLGSDAIFSCAWTGNPSLTIVWMKRGS-------GVVLSNEKTLTLKSVRQE-DAGK 395
+ G D C G P +I W K + V N TL L V++E D G+
Sbjct: 513 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGE 572
Query: 396 YVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSW 455
Y C +V + + V +TV PP I + G++ I C + S P I W
Sbjct: 573 YTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQ- 631
Query: 456 KENVLESGTSGRYTVETISTEEGVISTLTISNI 488
K+ G+ G T++ I S+L ISN+
Sbjct: 632 KDGRPIPGSLG-VTIDNID----FTSSLRISNL 659
Score = 34.7 bits (78), Expect = 0.35
Identities = 42/172 (24%), Positives = 71/172 (41%), Gaps = 36/172 (20%)
Query: 351 DAIFSCAWTGNPSLTIVWMKRGSG----VVLSNEKTL------TLKSVRQEDAGKYVCRA 400
D + C G+PS + WMK +G V + +++ +++V+ ED+G Y C A
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 401 VVPRVGAGEREVTLTVNGPP---------IISSTQTQHALHGEKG--QIKCFIRSTPPPD 449
G+ E + L V PP SS+ T L G+ G I+ +I +
Sbjct: 1362 -NNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDN 1420
Query: 450 RIAW----------SWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRA 491
W S++ L+ GT ++T+ T + + IS I+ A
Sbjct: 1421 SEQWGSFPISPSERSYRLENLKCGTWYKFTL----TAQNGVGPGRISEIIEA 1468
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 87.0 bits (214), Expect = 6e-17
Identities = 109/451 (24%), Positives = 170/451 (37%), Gaps = 56/451 (12%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+ P D +V G+P TL C A + W K G + +D + L+ L
Sbjct: 72 EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL---F 128
Query: 111 HLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGD 164
L+I+ R D+ VY C A + A+ S A L V + DD P + + G+
Sbjct: 129 FLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDD--FRQNPSDVMVAVGE 185
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P + C P +I W + G ++ + +R GK L I+ +
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRGGK-------LMITYTRKSDAGK 237
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
VC TN E + ++ P V ++D+ F C A+ +P T RW
Sbjct: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA-EFKCEARGDPVPT-VRW 295
Query: 285 AKR-GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDVYFGP 335
K G++ K Y D+T V+ C N +G S T+ V P
Sbjct: 296 RKDDGELPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
Query: 336 RMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------SNEK 381
+P+ +V LG F C TGNP I W + GS +L S
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 382 TLTLKSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPIISSTQTQHALHGEKG 436
LT+ +V++ D G Y+C+ + + EVT + PP+I + +
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
Query: 437 QIKCFIRSTPPPDRIAWSWKENVLESGTSGR 467
+ + + P I W K+ VL S R
Sbjct: 472 FVLSCVATGSPVPTILWR-KDGVLVSTQDSR 501
Score = 71.6 bits (174), Expect = 3e-12
Identities = 114/500 (22%), Positives = 186/500 (37%), Gaps = 103/500 (20%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDG---------LALGVGRDLSSYP- 97
F Q P D +V G+P + C P + + W KDG + + G+ + +Y
Sbjct: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTR 231
Query: 98 -----QYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVI 152
+Y+ VG ++ GE +E+ + V E + + RP+ L V V
Sbjct: 232 KSDAGKYVCVGTNMVGER-----ESEVAELTVLE----RPSFVKRPSNLAVTV------- 275
Query: 153 LGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTL 212
D C A P ++ W + + + Y +RD + +
Sbjct: 276 ----------DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSRYE---IRD---DHTLKIR 318
Query: 213 FISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCS 272
++ GD+ S C A N + G E S T+ +Q PP + Q V VTF C
Sbjct: 319 KVTAGDM---GSYTCVAEN--MVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 373
Query: 273 AKANPAVTQYRWAKRG--------QIIKEASGEVYRTTVDYTYFSEPVS------CEVTN 318
A NP + W + G Q + +S T D T + S C+ N
Sbjct: 374 ATGNPQPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 432
Query: 319 ALGSTNLSRTVDVYF------GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRG 372
GS ++V P + P + V + + SC TG+P TI+W K
Sbjct: 433 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK-- 490
Query: 373 SGVVLSNEKT---------LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN----GP 419
GV++S + + L ++ + D G+Y C A P +GE + + G
Sbjct: 491 DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP---SGEATWSAYIEVQEFGV 547
Query: 420 PIISSTQTQHAL---HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTE 476
P+ T L K ++ R+T + SW+ N+ T Y +E S
Sbjct: 548 PVQPPRPTDPNLIPSAPSKPEVTDVSRNT-----VTLSWQPNLNSGATPTSYIIEAFSHA 602
Query: 477 EGVISTLTISNIVRADFQTI 496
G S T++ V+ + I
Sbjct: 603 SG-SSWQTVAENVKTETSAI 621
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/65 (38%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 311 PVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK 370
P S N+LG T SR F PR+ P L+V G A +C G P+ TI W K
Sbjct: 45 PTSDNDDNSLGYTG-SRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 103
Query: 371 RGSGV 375
G V
Sbjct: 104 GGERV 108
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/454 (24%), Positives = 171/454 (37%), Gaps = 59/454 (12%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+ P D +V G+P TL C A + W K G + +D + L+ L
Sbjct: 33 EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL---F 89
Query: 111 HLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGD 164
L+I+ R D+ VY C A + A+ S A L V + DD P + + G+
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDD--FRQNPSDVMVAVGE 146
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P + C P +I W + G ++ + +R GK L I+ +
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRGGK-------LMITYTRKSDAGK 198
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
VC TN E + ++ P V ++D+ F C A+ +P T RW
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA-EFKCEARGDPVPT-VRW 256
Query: 285 AKR-GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDVYFG- 334
K G++ K Y D+T V+ C N +G S T+ V G
Sbjct: 257 RKDDGELPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 335 --PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------S 378
P +P+ +V LG F C TGNP I W + GS +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 379 NEKTLTLKSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPIISSTQTQHALHG 433
LT+ +V++ D G Y+C+ + + EVT + PP+I +
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGR 467
+ + + + P I W K+ VL S R
Sbjct: 433 DGTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR 465
Score = 66.2 bits (160), Expect = 1e-10
Identities = 114/503 (22%), Positives = 186/503 (36%), Gaps = 106/503 (21%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDG---------LALGVGRDLSSYP- 97
F Q P D +V G+P + C P + + W KDG + + G+ + +Y
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTR 192
Query: 98 -----QYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVI 152
+Y+ VG ++ GE +E+ + V E + + RP+ L V V
Sbjct: 193 KSDAGKYVCVGTNMVGER-----ESEVAELTVLE----RPSFVKRPSNLAVTV------- 236
Query: 153 LGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTL 212
D C A P ++ W + + + Y +RD + +
Sbjct: 237 ----------DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSRYE---IRD---DHTLKIR 279
Query: 213 FISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQ---HPPLVNLSVEPQPVLEDNVVTF 269
++ GD+ S C A N + G E S T+ +Q PP + Q V VTF
Sbjct: 280 KVTAGDM---GSYTCVAEN--MVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 270 HCSAKANPAVTQYRWAKRG--------QIIKEASGEVYRTTVDYTYFSEPVS------CE 315
C A NP + W + G Q + +S T D T + S C+
Sbjct: 335 QCEATGNPQPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 316 VTNALGSTNLSRTVDVYF------GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWM 369
N GS ++V P + P + V + + SC TG+P TI+W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 370 KRGSGVVLSNEKT---------LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN--- 417
K GV++S + + L ++ + D G+Y C A P +GE + +
Sbjct: 454 K--DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP---SGEATWSAYIEVQE 508
Query: 418 -GPPIISSTQTQHAL---HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETI 473
G P+ T L K ++ R+T + SW+ N+ T Y +E
Sbjct: 509 FGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT-----VTLSWQPNLNSGATPTSYIIEAF 563
Query: 474 STEEGVISTLTISNIVRADFQTI 496
S G S T++ V+ + I
Sbjct: 564 SHASG-SSWQTVAENVKTETSAI 585
Score = 36.6 bits (83), Expect = 0.092
Identities = 17/43 (39%), Positives = 21/43 (48%)
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
F PR+ P L+V G A +C G P+ TI W K G V
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 69
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/454 (24%), Positives = 171/454 (37%), Gaps = 59/454 (12%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+ P D +V G+P TL C A + W K G + +D + L+ L
Sbjct: 33 EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL---F 89
Query: 111 HLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGD 164
L+I+ R D+ VY C A + A+ S A L V + DD P + + G+
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDD--FRQNPSDVMVAVGE 146
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P + C P +I W + G ++ + +R GK L I+ +
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRGGK-------LMITYTRKSDAGK 198
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
VC TN E + ++ P V ++D+ F C A+ +P T RW
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA-EFKCEARGDPVPT-VRW 256
Query: 285 AKR-GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDVYFG- 334
K G++ K Y D+T V+ C N +G S T+ V G
Sbjct: 257 RKDDGELPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 335 --PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------S 378
P +P+ +V LG F C TGNP I W + GS +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 379 NEKTLTLKSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPIISSTQTQHALHG 433
LT+ +V++ D G Y+C+ + + EVT + PP+I +
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGR 467
+ + + + P I W K+ VL S R
Sbjct: 433 DGTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR 465
Score = 66.2 bits (160), Expect = 1e-10
Identities = 114/503 (22%), Positives = 186/503 (36%), Gaps = 106/503 (21%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDG---------LALGVGRDLSSYP- 97
F Q P D +V G+P + C P + + W KDG + + G+ + +Y
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTR 192
Query: 98 -----QYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVI 152
+Y+ VG ++ GE +E+ + V E + + RP+ L V V
Sbjct: 193 KSDAGKYVCVGTNMVGER-----ESEVAELTVLE----RPSFVKRPSNLAVTV------- 236
Query: 153 LGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTL 212
D C A P ++ W + + + Y +RD + +
Sbjct: 237 ----------DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSRYE---IRD---DHTLKIR 279
Query: 213 FISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQ---HPPLVNLSVEPQPVLEDNVVTF 269
++ GD+ S C A N + G E S T+ +Q PP + Q V VTF
Sbjct: 280 KVTAGDM---GSYTCVAEN--MVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 270 HCSAKANPAVTQYRWAKRG--------QIIKEASGEVYRTTVDYTYFSEPVS------CE 315
C A NP + W + G Q + +S T D T + S C+
Sbjct: 335 QCEATGNPQPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 316 VTNALGSTNLSRTVDVYF------GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWM 369
N GS ++V P + P + V + + SC TG+P TI+W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 370 KRGSGVVLSNEKT---------LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN--- 417
K GV++S + + L ++ + D G+Y C A P +GE + +
Sbjct: 454 K--DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP---SGEATWSAYIEVQE 508
Query: 418 -GPPIISSTQTQHAL---HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETI 473
G P+ T L K ++ R+T + SW+ N+ T Y +E
Sbjct: 509 FGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT-----VTLSWQPNLNSGATPTSYIIEAF 563
Query: 474 STEEGVISTLTISNIVRADFQTI 496
S G S T++ V+ + I
Sbjct: 564 SHASG-SSWQTVAENVKTETSAI 585
Score = 36.6 bits (83), Expect = 0.092
Identities = 17/43 (39%), Positives = 21/43 (48%)
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
F PR+ P L+V G A +C G P+ TI W K G V
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 69
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/454 (24%), Positives = 171/454 (37%), Gaps = 59/454 (12%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+ P D +V G+P TL C A + W K G + +D + L+ L
Sbjct: 33 EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL---F 89
Query: 111 HLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGD 164
L+I+ R D+ VY C A + A+ S A L V + DD P + + G+
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDD--FRQNPSDVMVAVGE 146
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P + C P +I W + G ++ + +R GK L I+ +
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRGGK-------LMITYTRKSDAGK 198
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
VC TN E + ++ P V ++D+ F C A+ +P T RW
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA-EFKCEARGDPVPT-VRW 256
Query: 285 AKR-GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDVYFG- 334
K G++ K Y D+T V+ C N +G S T+ V G
Sbjct: 257 RKDDGELPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 335 --PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------S 378
P +P+ +V LG F C TGNP I W + GS +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 379 NEKTLTLKSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPIISSTQTQHALHG 433
LT+ +V++ D G Y+C+ + + EVT + PP+I +
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGR 467
+ + + + P I W K+ VL S R
Sbjct: 433 DGTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR 465
Score = 66.2 bits (160), Expect = 1e-10
Identities = 114/503 (22%), Positives = 186/503 (36%), Gaps = 106/503 (21%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDG---------LALGVGRDLSSYP- 97
F Q P D +V G+P + C P + + W KDG + + G+ + +Y
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTR 192
Query: 98 -----QYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVI 152
+Y+ VG ++ GE +E+ + V E + + RP+ L V V
Sbjct: 193 KSDAGKYVCVGTNMVGER-----ESEVAELTVLE----RPSFVKRPSNLAVTV------- 236
Query: 153 LGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTL 212
D C A P ++ W + + + Y +RD + +
Sbjct: 237 ----------DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSRYE---IRD---DHTLKIR 279
Query: 213 FISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQ---HPPLVNLSVEPQPVLEDNVVTF 269
++ GD+ S C A N + G E S T+ +Q PP + Q V VTF
Sbjct: 280 KVTAGDM---GSYTCVAEN--MVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 270 HCSAKANPAVTQYRWAKRG--------QIIKEASGEVYRTTVDYTYFSEPVS------CE 315
C A NP + W + G Q + +S T D T + S C+
Sbjct: 335 QCEATGNPQPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 316 VTNALGSTNLSRTVDVYF------GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWM 369
N GS ++V P + P + V + + SC TG+P TI+W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 370 KRGSGVVLSNEKT---------LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN--- 417
K GV++S + + L ++ + D G+Y C A P +GE + +
Sbjct: 454 K--DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP---SGEATWSAYIEVQE 508
Query: 418 -GPPIISSTQTQHAL---HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETI 473
G P+ T L K ++ R+T + SW+ N+ T Y +E
Sbjct: 509 FGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT-----VTLSWQPNLNSGATPTSYIIEAF 563
Query: 474 STEEGVISTLTISNIVRADFQTI 496
S G S T++ V+ + I
Sbjct: 564 SHASG-SSWQTVAENVKTETSAI 585
Score = 36.6 bits (83), Expect = 0.092
Identities = 17/43 (39%), Positives = 21/43 (48%)
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
F PR+ P L+V G A +C G P+ TI W K G V
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 69
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/454 (24%), Positives = 171/454 (37%), Gaps = 59/454 (12%)
Query: 52 QQPQDQVVVSGQPVTLLC-AIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEH 110
+ P D +V G+P TL C A + W K G + +D + L+ L
Sbjct: 33 EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL---F 89
Query: 111 HLKIL--RAELQDDAVYECQA---IQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGD 164
L+I+ R D+ VY C A + A+ S A L V + DD P + + G+
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDD--FRQNPSDVMVAVGE 146
Query: 165 PLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQS 224
P + C P +I W + G ++ + +R GK L I+ +
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRGGK-------LMITYTRKSDAGK 198
Query: 225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRW 284
VC TN E + ++ P V ++D+ F C A+ +P T RW
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA-EFKCEARGDPVPT-VRW 256
Query: 285 AKR-GQIIKEASGEVYRTTVDYTYFSEPVS--------CEVTNALGSTNLSRTVDVYFG- 334
K G++ K Y D+T V+ C N +G S T+ V G
Sbjct: 257 RKDDGELPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 335 --PRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVL--------------S 378
P +P+ +V LG F C TGNP I W + GS +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 379 NEKTLTLKSVRQEDAGKYVCRAVVPR---VGAGEREVT--LTVNGPPIISSTQTQHALHG 433
LT+ +V++ D G Y+C+ + + EVT + PP+I +
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 434 EKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGR 467
+ + + + P I W K+ VL S R
Sbjct: 433 DGTFVLSCVATGSPVPTILWR-KDGVLVSTQDSR 465
Score = 66.2 bits (160), Expect = 1e-10
Identities = 114/503 (22%), Positives = 186/503 (36%), Gaps = 106/503 (21%)
Query: 50 FSQQPQDQVVVSGQPVTLLCAIP--EYDGFVLWIKDG---------LALGVGRDLSSYP- 97
F Q P D +V G+P + C P + + W KDG + + G+ + +Y
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTR 192
Query: 98 -----QYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVI 152
+Y+ VG ++ GE +E+ + V E + + RP+ L V V
Sbjct: 193 KSDAGKYVCVGTNMVGER-----ESEVAELTVLE----RPSFVKRPSNLAVTV------- 236
Query: 153 LGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTL 212
D C A P ++ W + + + Y +RD + +
Sbjct: 237 ----------DDSAEFKCEA-RGDPVPTVRWRKDDGELPKSRYE---IRD---DHTLKIR 279
Query: 213 FISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQ---HPPLVNLSVEPQPVLEDNVVTF 269
++ GD+ S C A N + G E S T+ +Q PP + Q V VTF
Sbjct: 280 KVTAGDM---GSYTCVAEN--MVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 270 HCSAKANPAVTQYRWAKRG--------QIIKEASGEVYRTTVDYTYFSEPVS------CE 315
C A NP + W + G Q + +S T D T + S C+
Sbjct: 335 QCEATGNPQPAIF-WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 316 VTNALGSTNLSRTVDVYF------GPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWM 369
N GS ++V P + P + V + + SC TG+P TI+W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 370 KRGSGVVLSNEKT---------LTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVN--- 417
K GV++S + + L ++ + D G+Y C A P +GE + +
Sbjct: 454 K--DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP---SGEATWSAYIEVQE 508
Query: 418 -GPPIISSTQTQHAL---HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETI 473
G P+ T L K ++ R+T + SW+ N+ T Y +E
Sbjct: 509 FGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT-----VTLSWQPNLNSGATPTSYIIEAF 563
Query: 474 STEEGVISTLTISNIVRADFQTI 496
S G S T++ V+ + I
Sbjct: 564 SHASG-SSWQTVAENVKTETSAI 585
Score = 36.6 bits (83), Expect = 0.092
Identities = 17/43 (39%), Positives = 21/43 (48%)
Query: 333 FGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGV 375
F PR+ P L+V G A +C G P+ TI W K G V
Sbjct: 27 FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 69
>gi|31543106 basal cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 628
Score = 80.5 bits (197), Expect = 6e-15
Identities = 126/539 (23%), Positives = 203/539 (37%), Gaps = 84/539 (15%)
Query: 106 LSGEHHLKILRAELQDDAVYEC--QAIQAAIRSRPARLTVLVPPDDPVILG--GPVISLR 161
L + L + A++ D+ Y C +A A ARL V P+ + G + +
Sbjct: 104 LDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVME 163
Query: 162 AGDPLNLTCHADNAKPAASIIWLRKGEVI--------NGATYSKTLLRDGKRESIVSTLF 213
TC++ N PA I W R G+ + G S+T+ S+ STL+
Sbjct: 164 DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLY 223
Query: 214 ISPGDVENGQSIVCRATNKAIPGGKE---TSVTIDIQ-HPPLVNL-------SVEPQPVL 262
+ + S C A + ++P G+ S T + H P ++ S V
Sbjct: 224 LRLRKDDRDASFHC-AAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVR 282
Query: 263 EDNVVTFHCSAKANPA--VTQYRWAKRGQIIKEASGEVYRTTVDYTY-FSEPVSCEVT-- 317
E + V C +P+ T +R + + + E T T S C V
Sbjct: 283 EGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDY 342
Query: 318 NALGSTNLSRTVDV---YFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSG 374
+A LS+T+++ Y P +E + L + L S A+ +C+ G P+ + W K
Sbjct: 343 DAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTK--DS 400
Query: 375 VVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGER--EVTLTVNGPPIISSTQTQHAL- 431
L + L+L S+ + G YVC A +P V R TL V G P + + + +
Sbjct: 401 TPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKAD 460
Query: 432 ----HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISN 487
G++ + C R P P +++WS G E I +G +S+
Sbjct: 461 GSWREGDEVTLICSARGHPDP-KLSWS---------QLGGSPAEPIPGRQGWVSSSLTLK 510
Query: 488 IVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVA 547
+ A + +C A N G+ + S S AG+ ++ VAV G
Sbjct: 511 VTSALSRDGISCEASNPHGNKRHVFHFGTV-SPQTSQAGV--------AVMAVAVSVG-- 559
Query: 548 FLVLMATIVAFCCARS------QRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ 600
L+L+ V +C R QR KG P G G HS +Q
Sbjct: 560 -LLLLVVAVFYCVRRKGGPCCRQRREKGA---------------PPPGEPGLSHSGSEQ 602
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,024,913
Number of Sequences: 37866
Number of extensions: 1456650
Number of successful extensions: 7762
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 253
Number of HSP's that attempted gapping in prelim test: 4934
Number of HSP's gapped (non-prelim): 1824
length of query: 778
length of database: 18,247,518
effective HSP length: 110
effective length of query: 668
effective length of database: 14,082,258
effective search space: 9406948344
effective search space used: 9406948344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.