Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 25777608
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
(975 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens] 1948 0.0
gi|25777610 NLR family member X1 isoform 2 [Homo sapiens] 1742 0.0
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 119 1e-26
gi|5174617 nucleotide-binding oligomerization domain containing ... 108 2e-23
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 105 2e-22
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 105 2e-22
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 105 2e-22
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 101 3e-21
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 101 3e-21
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 101 3e-21
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 101 3e-21
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 101 3e-21
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 101 3e-21
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 100 5e-21
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 100 5e-21
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 100 5e-21
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 100 5e-21
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 100 5e-21
gi|118918429 NOD3 protein [Homo sapiens] 100 7e-21
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 96 2e-19
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 94 6e-19
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 93 1e-18
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 92 2e-18
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 84 5e-16
gi|11545912 nucleotide-binding oligomerization domain containing... 83 1e-15
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 83 1e-15
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 73 1e-12
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 73 1e-12
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 72 3e-12
gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain... 57 8e-08
>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
Length = 975
Score = 1948 bits (5047), Expect = 0.0
Identities = 975/975 (100%), Positives = 975/975 (100%)
Query: 1 MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSA 60
MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSA
Sbjct: 1 MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSA 60
Query: 61 PPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTP 120
PPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTP
Sbjct: 61 PPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTP 120
Query: 121 DELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMV 180
DELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMV
Sbjct: 121 DELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMV 180
Query: 181 LDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFV 240
LDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFV
Sbjct: 181 LDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFV 240
Query: 241 LHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPS 300
LHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPS
Sbjct: 241 LHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPS 300
Query: 301 KYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEG 360
KYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEG
Sbjct: 301 KYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEG 360
Query: 361 HHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLS 420
HHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLS
Sbjct: 361 HHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLS 420
Query: 421 LMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAP 480
LMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAP
Sbjct: 421 LMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAP 480
Query: 481 CVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIM 540
CVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIM
Sbjct: 481 CVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIM 540
Query: 541 AKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGAS 600
AKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGAS
Sbjct: 541 AKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGAS 600
Query: 601 ILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKK 660
ILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKK
Sbjct: 601 ILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKK 660
Query: 661 KLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVL 720
KLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVL
Sbjct: 661 KLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVL 720
Query: 721 GSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQ 780
GSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQ
Sbjct: 721 GSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQ 780
Query: 781 ITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQEL 840
ITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQEL
Sbjct: 781 ITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQEL 840
Query: 841 NVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSL 900
NVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSL
Sbjct: 841 NVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSL 900
Query: 901 TEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVE 960
TEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVE
Sbjct: 901 TEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVE 960
Query: 961 GEVRALLEQLGSSGS 975
GEVRALLEQLGSSGS
Sbjct: 961 GEVRALLEQLGSSGS 975
>gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]
Length = 921
Score = 1742 bits (4511), Expect = 0.0
Identities = 868/868 (100%), Positives = 868/868 (100%)
Query: 1 MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSA 60
MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSA
Sbjct: 1 MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSA 60
Query: 61 PPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTP 120
PPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTP
Sbjct: 61 PPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTP 120
Query: 121 DELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMV 180
DELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMV
Sbjct: 121 DELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMV 180
Query: 181 LDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFV 240
LDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFV
Sbjct: 181 LDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFV 240
Query: 241 LHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPS 300
LHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPS
Sbjct: 241 LHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPS 300
Query: 301 KYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEG 360
KYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEG
Sbjct: 301 KYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEG 360
Query: 361 HHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLS 420
HHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLS
Sbjct: 361 HHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLS 420
Query: 421 LMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAP 480
LMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAP
Sbjct: 421 LMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAP 480
Query: 481 CVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIM 540
CVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIM
Sbjct: 481 CVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIM 540
Query: 541 AKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGAS 600
AKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGAS
Sbjct: 541 AKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGAS 600
Query: 601 ILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKK 660
ILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKK
Sbjct: 601 ILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKK 660
Query: 661 KLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVL 720
KLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVL
Sbjct: 661 KLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVL 720
Query: 721 GSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQ 780
GSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQ
Sbjct: 721 GSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQ 780
Query: 781 ITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQEL 840
ITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQEL
Sbjct: 781 ITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQEL 840
Query: 841 NVAYNGAGDTAALALARAAREHPSLELL 868
NVAYNGAGDTAALALARAAREHPSLELL
Sbjct: 841 NVAYNGAGDTAALALARAAREHPSLELL 868
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 119 bits (299), Expect = 1e-26
Identities = 207/850 (24%), Positives = 330/850 (38%), Gaps = 123/850 (14%)
Query: 74 SATEAIQRHRRNLAEWFSRLP-REERQFGPTFALDTVHVDPVIRESTPDELLRPPAELAL 132
S +E +++R ++ + +R+ R R T + + P + P+E L P A
Sbjct: 114 SVSEYKKKYREHVLQLHARVKERNARSVKITKRFTKLLIAP--ESAAPEEALGP----AE 167
Query: 133 EHQPPQAGLPPL-ALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAF 191
E +P +A ++LF D GRR TVVL G G GK+ +K++ DW G+L
Sbjct: 168 EPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQG 227
Query: 192 ELLIPF--SCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
++ F C +L P SL L+ + +P M A LLF+L G + L
Sbjct: 228 QVDFAFFMPCGELLE-RPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELP- 285
Query: 250 DFRLAG--TGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVG-RY 306
L G C+DP E A ++ LL K +LP A +LVTTR +A GR+ + +
Sbjct: 286 --ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQC 343
Query: 307 GEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAA 366
E+ GFSD + +K +++ + + + R ++ + + A
Sbjct: 344 AEVRGFSDKDKKKYFYKF--------------------FRDERRAERAYRFVKENETLFA 383
Query: 367 ACFLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAY 424
CF+P CW+VC L G+ L TS T+ + L F L S ++ +
Sbjct: 384 LCFVPFVCWIVCTV---LRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQG 440
Query: 425 AARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
R + +LA EGV R+ F+ E+E + L + FL+ P
Sbjct: 441 DLRNLCRLAREGVLGRRAQFA--------------EKELEQLELRGSKVQTLFLSKKELP 486
Query: 485 G---RAGTFVFTVPAMQEYLAALYIVL---GLRKTTLQKVGKEVAELVGRVGEDVSLVLG 538
G T+ F + QE+LAAL +L G+ +T VG L G LVL
Sbjct: 487 GVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAAGGVG---TLLRGDAQPHSHLVL- 542
Query: 539 IMAKLLPLRALPLLFNLIKV-----VPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDV 593
LF L+ + R FG MV E V Q L + + V
Sbjct: 543 ---------TTRFLFGLLSAERMRDIERHFGCMVS---ERVKQE-ALRWVQGQGQGCPGV 589
Query: 594 LDQMGASILGVEGPRRHPDEPPEDEVFE--LFPM-FMGGLLSAHNRAVLAQLGCPIKNLD 650
++ G+E +EP E+E E +P+ + L A + Q C L
Sbjct: 590 APEVTEGAKGLE----DTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPEL- 644
Query: 651 ALENAQAIKKKLGKLGRQV--LPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRM 708
AL+ + + + L V P + L + ++ + L+ G
Sbjct: 645 ALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSS 704
Query: 709 TPVKCTVVAAVLGSGRHALDE-------VNLASCQLDPAGLRTLLPVFLRA---RKLGLQ 758
+ A++L A+ + + L+ C+L A R L A +LGL
Sbjct: 705 QGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLL 764
Query: 759 LNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS----- 813
N L + L + L QC++ T+R+ P G+ L+ L + ++T L
Sbjct: 765 HNRLSEAGLRMLSEGLAWPQCRVQTVRV-QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQ 823
Query: 814 ------------LLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAARE 861
L H G G + L L + +L + LQEL D A
Sbjct: 824 LPAPMVTYLCAVLQHQGCGLQTLSLASVELS-EQSLQELQAVKRAKPDLVITHPALDGHP 882
Query: 862 HPSLELLHLY 871
P EL+ +
Sbjct: 883 QPPKELISTF 892
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 108 bits (271), Expect = 2e-23
Identities = 180/757 (23%), Positives = 293/757 (38%), Gaps = 125/757 (16%)
Query: 160 QTVVLYGTVGTGKSTLVRKMVLDWCYGRLPA-FELLIPFSCEDLSSLGPAPASLCQ-LVA 217
+T+ + G G GKS L++++ W GRL A + F C S + Q L+
Sbjct: 196 ETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLF 255
Query: 218 QRYT----PLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIV 273
+ Y +EV + LF GL+ L+ D L+ S P EP P ++
Sbjct: 256 KHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLA 315
Query: 274 NLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGY 333
NLL +L AS L+T R +P +++ + + GFS ++L+ Y
Sbjct: 316 NLLSGKLLKGASKLLTARTGI--EVPRQFLRKKVLLRGFSPSHLR-------------AY 360
Query: 334 AVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATL-HFLHAPTPAGQ 392
A + A +D L+ L E + + + C +P +CW++ HF A + Q
Sbjct: 361 A---RRMFPERALQDRLLSQL----EANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQ 413
Query: 393 ------TLTSIYTSFLRLNFSGETLDSTDPSNLSLM--------AYAAR----TMGKLAY 434
TLT ++ ++ L+ PS+L +A R ++G++A+
Sbjct: 414 LPDCTMTLTDVFLLVTEVH-----LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAH 468
Query: 435 EGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAG---TFV 491
G+ F T+EE Q + RD FL E G G ++
Sbjct: 469 RGMEKSLFVF--------------TQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYE 514
Query: 492 FTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPL 551
F +Q + A ++VL R T Q++ + E + G + LP + L
Sbjct: 515 FFHLTLQAFFTAFFLVLDDRVGT-QELLRFFQEWMPPAG---AATTSCYPPFLPFQCL-- 568
Query: 552 LFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHP 611
+ G +RE ++F+ +D++ L G + RH
Sbjct: 569 -------------QGSGPARE--------DLFKNKDHFQFTNLFLCGLLSKAKQKLLRH- 606
Query: 612 DEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKN-LDALENAQAIKKKLGKLGRQVL 670
+ L +A+ A L ++ L +L Q + QV
Sbjct: 607 -------------LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQV------ESFNQVQ 647
Query: 671 PPSELLDHLFFHYEFQNQRFSAEVLSSL--RQLNLAGVRMTPVKCTVVAAVLGS--GRHA 726
+ L YE Q+Q+ + L L C+ ++ VL R A
Sbjct: 648 AMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLA 707
Query: 727 LDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRL 786
LD L + L+ G+R L P F R L L +N + K L + L + +T L L
Sbjct: 708 LD---LDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKI-VTYLGL 763
Query: 787 SNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNG 846
NN +T G + + L +THL L + EG + LA + ++ + E+ + N
Sbjct: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
Query: 847 AGDTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
GD A A A A R HPSL L L N +S+EG + L
Sbjct: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSL 860
Score = 46.2 bits (108), Expect = 1e-04
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 1/132 (0%)
Query: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
++G+ N +G E K + L + +TTL L++N ++ G L L NTS+ L
Sbjct: 816 EVGMWGNQVGDEGAKAFAEAL-RNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILW 874
Query: 814 LLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFN 873
L L DE E LA L N+ L+ L + N LA A + + + + L N
Sbjct: 875 LTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
Query: 874 ELSSEGRQVLRD 885
+ E +V D
Sbjct: 935 LIKPEEAKVYED 946
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 105 bits (263), Expect = 2e-22
Identities = 100/356 (28%), Positives = 161/356 (45%), Gaps = 54/356 (15%)
Query: 161 TVVLYGTVGTGKSTLVRKMVLDWCYGRL-PAFELLIPFSCEDLSSLGPAPASLCQLVAQR 219
TVVL+G G GK+TL +K +LDW L P SC++LS +GP S +L+++
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPC--SFAELISKD 230
Query: 220 YTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKY 279
+ L++ +P + A +LFV+ GL+ L + +C D E+ + ++ +LL++
Sbjct: 231 WPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRK 290
Query: 280 MLPQASILVTTRPSAIGRIP-SKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGS 338
MLP+A++LVTTRP A+ + Y + GF + + ++ YF G
Sbjct: 291 MLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEED-RRAYFLRHF----------GD 339
Query: 339 GVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFL----HAPTPAGQTL 394
A A L R+ Q+ +A P+ CW+VC TL P P T
Sbjct: 340 EDQAMRAFE------LMRSNAALFQLGSA---PAVCWIVCTTLKLQMEKGEDPVPTCLTR 390
Query: 395 TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV--CGC 452
T ++ FL F P L A RT+ LA +G+ ++ + F ED+ G
Sbjct: 391 TGLFLRFLCSRF---------PQGAQLRG-ALRTLSLLAAQGLWAQMSVFHREDLERLGV 440
Query: 453 LEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVL 508
E+ +R F I R+D + G + F + Q++L AL+ L
Sbjct: 441 QESDLRL---FLDGDILRQDRV-----------SKGCYSFIHLSFQQFLTALFYAL 482
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 5/187 (2%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLG 756
SL+ L L+ + ++ + +H L ++L +C+L A + L V + ++KL
Sbjct: 790 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 849
Query: 757 ---LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
L N +G K L + L + C++ TL L +T G L E L S+T+L
Sbjct: 850 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 909
Query: 814 LLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYF 872
L + GL +L L+ N L+ L + L A + LE L L
Sbjct: 910 LSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQ 968
Query: 873 NELSSEG 879
N L G
Sbjct: 969 NHLWKSG 975
Score = 32.7 bits (73), Expect = 1.7
Identities = 23/71 (32%), Positives = 32/71 (45%)
Query: 770 LRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAA 829
L DLL + +C + LRL + T A L N S+ HL L L DEG LL
Sbjct: 752 LCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYK 811
Query: 830 QLDRNRQLQEL 840
+ R + ++
Sbjct: 812 TMTRPKHFLQM 822
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 105 bits (263), Expect = 2e-22
Identities = 100/356 (28%), Positives = 161/356 (45%), Gaps = 54/356 (15%)
Query: 161 TVVLYGTVGTGKSTLVRKMVLDWCYGRL-PAFELLIPFSCEDLSSLGPAPASLCQLVAQR 219
TVVL+G G GK+TL +K +LDW L P SC++LS +GP S +L+++
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPC--SFAELISKD 230
Query: 220 YTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKY 279
+ L++ +P + A +LFV+ GL+ L + +C D E+ + ++ +LL++
Sbjct: 231 WPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRK 290
Query: 280 MLPQASILVTTRPSAIGRIP-SKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGS 338
MLP+A++LVTTRP A+ + Y + GF + + ++ YF G
Sbjct: 291 MLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEED-RRAYFLRHF----------GD 339
Query: 339 GVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFL----HAPTPAGQTL 394
A A L R+ Q+ +A P+ CW+VC TL P P T
Sbjct: 340 EDQAMRAFE------LMRSNAALFQLGSA---PAVCWIVCTTLKLQMEKGEDPVPTCLTR 390
Query: 395 TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV--CGC 452
T ++ FL F P L A RT+ LA +G+ ++ + F ED+ G
Sbjct: 391 TGLFLRFLCSRF---------PQGAQLRG-ALRTLSLLAAQGLWAQMSVFHREDLERLGV 440
Query: 453 LEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVL 508
E+ +R F I R+D + G + F + Q++L AL+ L
Sbjct: 441 QESDLRL---FLDGDILRQDRV-----------SKGCYSFIHLSFQQFLTALFYAL 482
Score = 43.9 bits (102), Expect = 7e-04
Identities = 40/150 (26%), Positives = 68/150 (45%), Gaps = 5/150 (3%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLG 756
SL+ L L+ + ++ + +H L ++L +C+L A + L V + ++KL
Sbjct: 790 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 849
Query: 757 ---LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
L N +G K L + L + C++ TL L +T G L E L S+T+L
Sbjct: 850 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 909
Query: 814 LLHTGLGDEGLELLAAQLDR-NRQLQELNV 842
L + GL +L L+ N L+ L +
Sbjct: 910 LSINQIA-RGLWILCQALENPNCNLKHLRL 938
Score = 32.7 bits (73), Expect = 1.7
Identities = 23/71 (32%), Positives = 32/71 (45%)
Query: 770 LRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAA 829
L DLL + +C + LRL + T A L N S+ HL L L DEG LL
Sbjct: 752 LCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYK 811
Query: 830 QLDRNRQLQEL 840
+ R + ++
Sbjct: 812 TMTRPKHFLQM 822
Score = 32.3 bits (72), Expect = 2.2
Identities = 34/125 (27%), Positives = 51/125 (40%), Gaps = 1/125 (0%)
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHL 812
+ L L N L E L + + + L L N LT A L L + +THL
Sbjct: 792 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 851
Query: 813 SLLHTGLGDEGLELLAAQLD-RNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLY 871
L +GD G++ L L + +LQ L + L+ A +E SL L L
Sbjct: 852 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS 911
Query: 872 FNELS 876
N+++
Sbjct: 912 INQIA 916
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 105 bits (263), Expect = 2e-22
Identities = 100/356 (28%), Positives = 161/356 (45%), Gaps = 54/356 (15%)
Query: 161 TVVLYGTVGTGKSTLVRKMVLDWCYGRL-PAFELLIPFSCEDLSSLGPAPASLCQLVAQR 219
TVVL+G G GK+TL +K +LDW L P SC++LS +GP S +L+++
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPC--SFAELISKD 230
Query: 220 YTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKY 279
+ L++ +P + A +LFV+ GL+ L + +C D E+ + ++ +LL++
Sbjct: 231 WPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRK 290
Query: 280 MLPQASILVTTRPSAIGRIP-SKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGS 338
MLP+A++LVTTRP A+ + Y + GF + + ++ YF G
Sbjct: 291 MLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEED-RRAYFLRHF----------GD 339
Query: 339 GVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFL----HAPTPAGQTL 394
A A L R+ Q+ +A P+ CW+VC TL P P T
Sbjct: 340 EDQAMRAFE------LMRSNAALFQLGSA---PAVCWIVCTTLKLQMEKGEDPVPTCLTR 390
Query: 395 TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV--CGC 452
T ++ FL F P L A RT+ LA +G+ ++ + F ED+ G
Sbjct: 391 TGLFLRFLCSRF---------PQGAQLRG-ALRTLSLLAAQGLWAQMSVFHREDLERLGV 440
Query: 453 LEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVL 508
E+ +R F I R+D + G + F + Q++L AL+ L
Sbjct: 441 QESDLRL---FLDGDILRQDRV-----------SKGCYSFIHLSFQQFLTALFYAL 482
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 5/187 (2%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLG 756
SL+ L L+ + ++ + +H L ++L +C+L A + L V + ++KL
Sbjct: 762 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 821
Query: 757 ---LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
L N +G K L + L + C++ TL L +T G L E L S+T+L
Sbjct: 822 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 881
Query: 814 LLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYF 872
L + GL +L L+ N L+ L + L A + LE L L
Sbjct: 882 LSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQ 940
Query: 873 NELSSEG 879
N L G
Sbjct: 941 NHLWKSG 947
Score = 32.7 bits (73), Expect = 1.7
Identities = 23/71 (32%), Positives = 32/71 (45%)
Query: 770 LRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAA 829
L DLL + +C + LRL + T A L N S+ HL L L DEG LL
Sbjct: 724 LCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYK 783
Query: 830 QLDRNRQLQEL 840
+ R + ++
Sbjct: 784 TMTRPKHFLQM 794
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 101 bits (252), Expect = 3e-21
Identities = 87/341 (25%), Positives = 152/341 (44%), Gaps = 45/341 (13%)
Query: 112 DPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTG 171
DP+++ S PD + L + + LF P + + V+L G G G
Sbjct: 293 DPLVKRSWPDYVEENRGHL-------------IEIRDLFGPGLDTQEPRIVILQGAAGIG 339
Query: 172 KSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPL 229
KSTL R++ W G+L F+ + FSC +L+ SL +L+ + T +
Sbjct: 340 KSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ--SKVVSLAELIGKDGTATPAPIRQ 397
Query: 230 MAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVT 289
+ + LLF+L G++ + + LC +PQ A++ +LL K +LP+AS L+T
Sbjct: 398 ILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLIT 457
Query: 290 TRPSAI-GRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRD 348
R +A+ IPS R+ E+ GFS+++ ++ +++ ++ A
Sbjct: 458 ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF------------- 504
Query: 349 HLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSG 408
R ++ + ++ A C +P WL C L TLTS T+ L L++
Sbjct: 505 -------RLVKSNKELWALCLVPWVSWLACTCL-MQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 409 ETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV 449
+ L + + R + LA EG+ +KT FS +D+
Sbjct: 557 QALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDL 591
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 1/143 (0%)
Query: 742 LRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLME 801
L ++L V ++L L NSL A K L L +C + TLRL+ LTA L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 802 GLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAR 860
GL N ++T L L L D G + L +L + + +LQ L + G LA
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 861 EHPSLELLHLYFNELSSEGRQVL 883
PSL+ L L N L G ++L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLL 942
Score = 50.4 bits (119), Expect = 8e-06
Identities = 56/197 (28%), Positives = 85/197 (43%), Gaps = 30/197 (15%)
Query: 693 EVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRA 752
+V +L++L+L+G ++ + L R L+ + LA C
Sbjct: 805 KVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGC----------------- 847
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL-AGNTSVTH 811
L E CKDL L +Q +T L LS N LT AG L + L + +
Sbjct: 848 --------GLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQR 898
Query: 812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLY 871
L L+ GL + + LA+ L + L+EL++ N D L R HP+ +L+ L
Sbjct: 899 LQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRLG 957
Query: 872 FNE--LSSEGRQVLRDL 886
++ LS E RQ LR L
Sbjct: 958 LDQTTLSDEMRQELRAL 974
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 101 bits (252), Expect = 3e-21
Identities = 87/341 (25%), Positives = 152/341 (44%), Gaps = 45/341 (13%)
Query: 112 DPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTG 171
DP+++ S PD + L + + LF P + + V+L G G G
Sbjct: 293 DPLVKRSWPDYVEENRGHL-------------IEIRDLFGPGLDTQEPRIVILQGAAGIG 339
Query: 172 KSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPL 229
KSTL R++ W G+L F+ + FSC +L+ SL +L+ + T +
Sbjct: 340 KSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ--SKVVSLAELIGKDGTATPAPIRQ 397
Query: 230 MAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVT 289
+ + LLF+L G++ + + LC +PQ A++ +LL K +LP+AS L+T
Sbjct: 398 ILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLIT 457
Query: 290 TRPSAI-GRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRD 348
R +A+ IPS R+ E+ GFS+++ ++ +++ ++ A
Sbjct: 458 ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF------------- 504
Query: 349 HLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSG 408
R ++ + ++ A C +P WL C L TLTS T+ L L++
Sbjct: 505 -------RLVKSNKELWALCLVPWVSWLACTCL-MQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 409 ETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV 449
+ L + + R + LA EG+ +KT FS +D+
Sbjct: 557 QALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDL 591
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 1/143 (0%)
Query: 742 LRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLME 801
L ++L V ++L L NSL A K L L +C + TLRL+ LTA L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 802 GLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAR 860
GL N ++T L L L D G + L +L + + +LQ L + G LA
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 861 EHPSLELLHLYFNELSSEGRQVL 883
PSL+ L L N L G ++L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLL 942
Score = 44.3 bits (103), Expect = 6e-04
Identities = 48/179 (26%), Positives = 75/179 (41%), Gaps = 28/179 (15%)
Query: 693 EVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRA 752
+V +L++L+L+G ++ + L R L+ + LA C
Sbjct: 805 KVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGC----------------- 847
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL-AGNTSVTH 811
L E CKDL L +Q +T L LS N LT AG L + L + +
Sbjct: 848 --------GLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQR 898
Query: 812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHL 870
L L+ GL + + LA+ L + L+EL++ N D L R HP+ +L+ L
Sbjct: 899 LQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRL 956
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 101 bits (252), Expect = 3e-21
Identities = 87/341 (25%), Positives = 152/341 (44%), Gaps = 45/341 (13%)
Query: 112 DPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTG 171
DP+++ S PD + L + + LF P + + V+L G G G
Sbjct: 293 DPLVKRSWPDYVEENRGHL-------------IEIRDLFGPGLDTQEPRIVILQGAAGIG 339
Query: 172 KSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPL 229
KSTL R++ W G+L F+ + FSC +L+ SL +L+ + T +
Sbjct: 340 KSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ--SKVVSLAELIGKDGTATPAPIRQ 397
Query: 230 MAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVT 289
+ + LLF+L G++ + + LC +PQ A++ +LL K +LP+AS L+T
Sbjct: 398 ILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLIT 457
Query: 290 TRPSAI-GRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRD 348
R +A+ IPS R+ E+ GFS+++ ++ +++ ++ A
Sbjct: 458 ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF------------- 504
Query: 349 HLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSG 408
R ++ + ++ A C +P WL C L TLTS T+ L L++
Sbjct: 505 -------RLVKSNKELWALCLVPWVSWLACTCL-MQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 409 ETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV 449
+ L + + R + LA EG+ +KT FS +D+
Sbjct: 557 QALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDL 591
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 1/143 (0%)
Query: 742 LRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLME 801
L ++L V ++L L NSL A K L L +C + TLRL+ LTA L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 802 GLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAR 860
GL N ++T L L L D G + L +L + + +LQ L + G LA
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 861 EHPSLELLHLYFNELSSEGRQVL 883
PSL+ L L N L G ++L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLL 942
Score = 50.4 bits (119), Expect = 8e-06
Identities = 56/197 (28%), Positives = 85/197 (43%), Gaps = 30/197 (15%)
Query: 693 EVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRA 752
+V +L++L+L+G ++ + L R L+ + LA C
Sbjct: 805 KVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGC----------------- 847
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL-AGNTSVTH 811
L E CKDL L +Q +T L LS N LT AG L + L + +
Sbjct: 848 --------GLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQR 898
Query: 812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLY 871
L L+ GL + + LA+ L + L+EL++ N D L R HP+ +L+ L
Sbjct: 899 LQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRLG 957
Query: 872 FNE--LSSEGRQVLRDL 886
++ LS E RQ LR L
Sbjct: 958 LDQTTLSDEMRQELRAL 974
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 101 bits (252), Expect = 3e-21
Identities = 87/341 (25%), Positives = 152/341 (44%), Gaps = 45/341 (13%)
Query: 112 DPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTG 171
DP+++ S PD + L + + LF P + + V+L G G G
Sbjct: 293 DPLVKRSWPDYVEENRGHL-------------IEIRDLFGPGLDTQEPRIVILQGAAGIG 339
Query: 172 KSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPL 229
KSTL R++ W G+L F+ + FSC +L+ SL +L+ + T +
Sbjct: 340 KSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ--SKVVSLAELIGKDGTATPAPIRQ 397
Query: 230 MAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVT 289
+ + LLF+L G++ + + LC +PQ A++ +LL K +LP+AS L+T
Sbjct: 398 ILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLIT 457
Query: 290 TRPSAI-GRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRD 348
R +A+ IPS R+ E+ GFS+++ ++ +++ ++ A
Sbjct: 458 ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF------------- 504
Query: 349 HLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSG 408
R ++ + ++ A C +P WL C L TLTS T+ L L++
Sbjct: 505 -------RLVKSNKELWALCLVPWVSWLACTCL-MQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 409 ETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV 449
+ L + + R + LA EG+ +KT FS +D+
Sbjct: 557 QALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDL 591
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 1/143 (0%)
Query: 742 LRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLME 801
L ++L V ++L L NSL A K L L +C + TLRL+ LTA L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 802 GLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAR 860
GL N ++T L L L D G + L +L + + +LQ L + G LA
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 861 EHPSLELLHLYFNELSSEGRQVL 883
PSL+ L L N L G ++L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLL 942
Score = 44.3 bits (103), Expect = 6e-04
Identities = 48/179 (26%), Positives = 75/179 (41%), Gaps = 28/179 (15%)
Query: 693 EVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRA 752
+V +L++L+L+G ++ + L R L+ + LA C
Sbjct: 805 KVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGC----------------- 847
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL-AGNTSVTH 811
L E CKDL L +Q +T L LS N LT AG L + L + +
Sbjct: 848 --------GLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQR 898
Query: 812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHL 870
L L+ GL + + LA+ L + L+EL++ N D L R HP+ +L+ L
Sbjct: 899 LQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRL 956
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 101 bits (252), Expect = 3e-21
Identities = 87/341 (25%), Positives = 152/341 (44%), Gaps = 45/341 (13%)
Query: 112 DPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTG 171
DP+++ S PD + L + + LF P + + V+L G G G
Sbjct: 293 DPLVKRSWPDYVEENRGHL-------------IEIRDLFGPGLDTQEPRIVILQGAAGIG 339
Query: 172 KSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPL 229
KSTL R++ W G+L F+ + FSC +L+ SL +L+ + T +
Sbjct: 340 KSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ--SKVVSLAELIGKDGTATPAPIRQ 397
Query: 230 MAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVT 289
+ + LLF+L G++ + + LC +PQ A++ +LL K +LP+AS L+T
Sbjct: 398 ILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLIT 457
Query: 290 TRPSAI-GRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRD 348
R +A+ IPS R+ E+ GFS+++ ++ +++ ++ A
Sbjct: 458 ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF------------- 504
Query: 349 HLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSG 408
R ++ + ++ A C +P WL C L TLTS T+ L L++
Sbjct: 505 -------RLVKSNKELWALCLVPWVSWLACTCL-MQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 409 ETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV 449
+ L + + R + LA EG+ +KT FS +D+
Sbjct: 557 QALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDL 591
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/143 (32%), Positives = 65/143 (45%), Gaps = 1/143 (0%)
Query: 742 LRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLME 801
L ++L V ++L L NSL A K L L +C + TLRL+ LTA L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 802 GLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAR 860
GL N ++T L L L D G + L +L + + +LQ L + G LA
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 861 EHPSLELLHLYFNELSSEGRQVL 883
PSL+ L L N L G ++L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLL 942
Score = 50.4 bits (119), Expect = 8e-06
Identities = 56/197 (28%), Positives = 85/197 (43%), Gaps = 30/197 (15%)
Query: 693 EVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRA 752
+V +L++L+L+G ++ + L R L+ + LA C
Sbjct: 805 KVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGC----------------- 847
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL-AGNTSVTH 811
L E CKDL L +Q +T L LS N LT AG L + L + +
Sbjct: 848 --------GLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQR 898
Query: 812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLY 871
L L+ GL + + LA+ L + L+EL++ N D L R HP+ +L+ L
Sbjct: 899 LQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRLG 957
Query: 872 FNE--LSSEGRQVLRDL 886
++ LS E RQ LR L
Sbjct: 958 LDQTTLSDEMRQELRAL 974
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 101 bits (252), Expect = 3e-21
Identities = 103/357 (28%), Positives = 160/357 (44%), Gaps = 56/357 (15%)
Query: 161 TVVLYGTVGTGKSTLVRKMVLDWCYGRL-PAFELLIPFSCEDLSSLGPAPASLCQLVAQR 219
TVVLYG G GK+TL +K++LDW L F+ SC +LS LG P S +LV +
Sbjct: 208 TVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLG--PCSFAELVFRD 265
Query: 220 YTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKY 279
+ L++ +P + A +LFV+ G + L +C D E+ + ++ +LL +
Sbjct: 266 WPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRV 325
Query: 280 MLPQASILVTTRPSAIG--RIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGG 337
MLP+A++LVTTRP A+ RI ++ Y + GF + + ++ YF G
Sbjct: 326 MLPKAALLVTTRPRALRDLRILAE-EPIYIRVEGFLEED-RRAYFLRHF----------G 373
Query: 338 SGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFL----HAPTPAGQT 393
A A L R+ Q+ +A P+ CW+VC TL P P T
Sbjct: 374 DEDQAMRAFE------LMRSNAALFQLGSA---PAVCWIVCTTLKLQMEKGEDPVPTCLT 424
Query: 394 LTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDV--CG 451
T ++ FL F P L A RT+ LA +G+ ++ + ED+ G
Sbjct: 425 RTGLFLRFLCSRF---------PQGAQLRG-ALRTLSLLAAQGLWAQTSVLHREDLERLG 474
Query: 452 CLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVL 508
E+ +R F I R+D + G + F + Q++L AL+ L
Sbjct: 475 VQESDLRL---FLDGDILRQDRV-----------SKGCYSFIHLSFQQFLTALFYTL 517
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/142 (26%), Positives = 66/142 (46%), Gaps = 3/142 (2%)
Query: 693 EVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRA 752
EV SL +NL+ + ++ L + L ++L +C L A + L V + +
Sbjct: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
Query: 753 RKLG---LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSV 809
R+L L N +G K L + L + +C++ TL L N +T+ G L + L +S+
Sbjct: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
Query: 810 THLSLLHTGLGDEGLELLAAQL 831
L L +G +G++ L L
Sbjct: 928 LCLDLGLNHIGVKGMKFLCEAL 949
Score = 34.3 bits (77), Expect = 0.58
Identities = 27/78 (34%), Positives = 41/78 (52%), Gaps = 2/78 (2%)
Query: 761 SLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL-AGNTSVTHLSLLHTGL 819
S+ P +C+DL L +Q + TL L NPL ++GV +L E L + ++ L L
Sbjct: 965 SIPPFSCEDLCSALSCNQ-SLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
Query: 820 GDEGLELLAAQLDRNRQL 837
DE +LL ++N QL
Sbjct: 1024 NDELNKLLEEIEEKNPQL 1041
Score = 33.9 bits (76), Expect = 0.76
Identities = 44/170 (25%), Positives = 70/170 (41%), Gaps = 7/170 (4%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRAR--- 753
+LR L L T + ++ L + +L VNL+ +L G + L +
Sbjct: 784 NLRYLGLVSCSATTQQWADLSLALEVNQ-SLTCVNLSDNELLDEGAKLLYTTLRHPKCFL 842
Query: 754 -KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLA-GNTSVTH 811
+L L+ L CKDL +L+ + ++T L L+ NP+ GV L EGL +
Sbjct: 843 QRLSLENCHLTEANCKDLAAVLVVSR-ELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQT 901
Query: 812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAARE 861
L L + + +G L L L L++ N G L A R+
Sbjct: 902 LVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRK 951
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 100 bits (250), Expect = 5e-21
Identities = 106/413 (25%), Positives = 183/413 (44%), Gaps = 60/413 (14%)
Query: 138 QAGLPPLALSQLFNPD-ACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELL 194
++ + P+ + LF+PD V TVV G G GK+ L RKM+LDW G L F+ L
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 195 IPFSCEDLS-----SLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
C ++S SLG S C P+ +++ S +LF++ G + L
Sbjct: 257 FYIHCREVSLVTQRSLGDLIMSCCP---DPNPPIHKIV----RKPSRILFLMDGFDELQG 309
Query: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKY-VGRYGE 308
F LC+D ++ + ++ +L+RK +LP+AS+L+TTRP A+ ++ R+ E
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 309 ICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAAC 368
I GFS+ ++ +F+ ++ AQ ++ N + C
Sbjct: 370 ILGFSEAKRKEYFFKYFSDE----------------AQARAAFSLIQEN----EVLFTMC 409
Query: 369 FLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAA 426
F+P CW+VC L +G++L TS T+ + + F L S +
Sbjct: 410 FIPLVCWIVCTG---LKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHL 466
Query: 427 RTMGKLAYEGVSSRKTYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
+ LA +G+ ++K F E D+ G +A + F +++F+++ C +
Sbjct: 467 WGLCSLAADGIWNQKILFEESDLRNHGLQKADV---SAFLRMNLFQKE------VDCEK- 516
Query: 485 GRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVL 537
+ F QE+ AA+Y +L K V +L R DV+++L
Sbjct: 517 ----FYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSR---DVTVLL 562
Score = 45.8 bits (107), Expect = 2e-04
Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 36/195 (18%)
Query: 727 LDEVNLASCQLDPAGLRTLLPVFLRAR---KLGLQLNSLGPEACKDLRDLLLHDQCQITT 783
L ++ L SC L A + L V + +L + N+LG L + + QC +
Sbjct: 829 LKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQK 888
Query: 784 LRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLEL----------------- 826
L L N+ LT+ + L L+ N ++THL L LGD+G++L
Sbjct: 889 LGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 948
Query: 827 ------------LAAQLDRNRQLQELNVAYNGAGDTAALALARAAREH----PSLELLHL 870
L+ L ++ L++L++ N GD + ++ +L L +
Sbjct: 949 DNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEM 1008
Query: 871 YFNELSSEGRQVLRD 885
YFN + + L++
Sbjct: 1009 YFNYETKSALETLQE 1023
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/215 (23%), Positives = 87/215 (40%), Gaps = 36/215 (16%)
Query: 703 LAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVF----LRARKLGLQ 758
L +T C + +VL + + +L E++L+ L G+R L R+L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQ-SLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLG 778
Query: 759 LNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL--------------- 803
L E C D+ L+L ++ L LS+N L G+ +L GL
Sbjct: 779 RCGLSHECCFDI-SLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSC 837
Query: 804 --------------AGNTSVTHLSLLHTGLGDEGLELLAAQLDRNR-QLQELNVAYNGAG 848
+ + S+T L + LGD G+ +L + + LQ+L + +G
Sbjct: 838 CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
Query: 849 DTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
AL+ + +L L+L N L +G ++L
Sbjct: 898 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL 932
Score = 41.6 bits (96), Expect = 0.004
Identities = 53/207 (25%), Positives = 84/207 (40%), Gaps = 32/207 (15%)
Query: 694 VLSSLRQLNLAGVRMTPVKCTVVAAVLGS---------GRHALDEVNLA---------SC 735
+L +L++L L +T C +A+VL + G +AL + +A C
Sbjct: 825 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
Query: 736 QLDPAGL-------------RTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQIT 782
L GL ++L L L+ N+LG + K L + LLH C++
Sbjct: 885 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
Query: 783 TLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL-DRNRQLQELN 841
L L N LT+ L L + S+ LSL + LGD G+ + L ++ LQ L
Sbjct: 945 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Query: 842 VAYNGAGDTAALALARAAREHPSLELL 868
++ AL E P L ++
Sbjct: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
Score = 39.7 bits (91), Expect = 0.014
Identities = 36/120 (30%), Positives = 49/120 (40%), Gaps = 3/120 (2%)
Query: 715 VVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRAR---KLGLQLNSLGPEACKDLR 771
+V VL S HA L + L + R L V ++ +L L NSLG + L
Sbjct: 703 MVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLC 762
Query: 772 DLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL 831
+ L H C I L L L+ + L+ N + L L LGD G+ LL L
Sbjct: 763 ETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGL 822
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 100 bits (250), Expect = 5e-21
Identities = 106/413 (25%), Positives = 183/413 (44%), Gaps = 60/413 (14%)
Query: 138 QAGLPPLALSQLFNPD-ACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELL 194
++ + P+ + LF+PD V TVV G G GK+ L RKM+LDW G L F+ L
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 195 IPFSCEDLS-----SLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
C ++S SLG S C P+ +++ S +LF++ G + L
Sbjct: 257 FYIHCREVSLVTQRSLGDLIMSCCP---DPNPPIHKIV----RKPSRILFLMDGFDELQG 309
Query: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKY-VGRYGE 308
F LC+D ++ + ++ +L+RK +LP+AS+L+TTRP A+ ++ R+ E
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 309 ICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAAC 368
I GFS+ ++ +F+ ++ AQ ++ N + C
Sbjct: 370 ILGFSEAKRKEYFFKYFSDE----------------AQARAAFSLIQEN----EVLFTMC 409
Query: 369 FLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAA 426
F+P CW+VC L +G++L TS T+ + + F L S +
Sbjct: 410 FIPLVCWIVCTG---LKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHL 466
Query: 427 RTMGKLAYEGVSSRKTYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
+ LA +G+ ++K F E D+ G +A + F +++F+++ C +
Sbjct: 467 WGLCSLAADGIWNQKILFEESDLRNHGLQKADV---SAFLRMNLFQKE------VDCEK- 516
Query: 485 GRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVL 537
+ F QE+ AA+Y +L K V +L R DV+++L
Sbjct: 517 ----FYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSR---DVTVLL 562
Score = 47.0 bits (110), Expect = 9e-05
Identities = 48/173 (27%), Positives = 72/173 (41%), Gaps = 4/173 (2%)
Query: 715 VVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRAR---KLGLQLNSLGPEACKDLR 771
+V VL S HA L + L + R L V ++ +L L NSLG + L
Sbjct: 703 MVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLC 762
Query: 772 DLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL 831
+ L H C I L L L+ + L+ N + L L LGD G+ LL L
Sbjct: 763 ETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGL 822
Query: 832 DRNR-QLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
L++L + +G AL+ + +L L+L N L +G ++L
Sbjct: 823 KHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL 875
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/165 (23%), Positives = 68/165 (41%), Gaps = 33/165 (20%)
Query: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
+L L N+LG + L L H C + L L N+ LT+ + L L+ N ++THL
Sbjct: 802 ELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
Query: 814 LLHTGLGDEGLEL-----------------------------LAAQLDRNRQLQELNVAY 844
L LGD+G++L L+ L ++ L++L++
Sbjct: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
Query: 845 NGAGDTAALALARAAREH----PSLELLHLYFNELSSEGRQVLRD 885
N GD + ++ +L L +YFN + + L++
Sbjct: 922 NDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 966
Score = 41.6 bits (96), Expect = 0.004
Identities = 45/176 (25%), Positives = 76/176 (43%), Gaps = 27/176 (15%)
Query: 694 VLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRAR 753
+L +L++L L +T V C+ +++VL + ++ L ++LR
Sbjct: 825 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQN-------------------LTHLYLRG- 864
Query: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
N+LG + K L + LLH C++ L L N LT+ L L + S+ LS
Sbjct: 865 ------NTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 918
Query: 814 LLHTGLGDEGLELLAAQL-DRNRQLQELNVAYNGAGDTAALALARAAREHPSLELL 868
L + LGD G+ + L ++ LQ L ++ AL E P L ++
Sbjct: 919 LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVV 974
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 100 bits (250), Expect = 5e-21
Identities = 106/413 (25%), Positives = 183/413 (44%), Gaps = 60/413 (14%)
Query: 138 QAGLPPLALSQLFNPD-ACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELL 194
++ + P+ + LF+PD V TVV G G GK+ L RKM+LDW G L F+ L
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 195 IPFSCEDLS-----SLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
C ++S SLG S C P+ +++ S +LF++ G + L
Sbjct: 257 FYIHCREVSLVTQRSLGDLIMSCCP---DPNPPIHKIV----RKPSRILFLMDGFDELQG 309
Query: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKY-VGRYGE 308
F LC+D ++ + ++ +L+RK +LP+AS+L+TTRP A+ ++ R+ E
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 309 ICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAAC 368
I GFS+ ++ +F+ ++ AQ ++ N + C
Sbjct: 370 ILGFSEAKRKEYFFKYFSDE----------------AQARAAFSLIQEN----EVLFTMC 409
Query: 369 FLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAA 426
F+P CW+VC L +G++L TS T+ + + F L S +
Sbjct: 410 FIPLVCWIVCTG---LKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHL 466
Query: 427 RTMGKLAYEGVSSRKTYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
+ LA +G+ ++K F E D+ G +A + F +++F+++ C +
Sbjct: 467 WGLCSLAADGIWNQKILFEESDLRNHGLQKADV---SAFLRMNLFQKE------VDCEK- 516
Query: 485 GRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVL 537
+ F QE+ AA+Y +L K V +L R DV+++L
Sbjct: 517 ----FYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSR---DVTVLL 562
Score = 45.8 bits (107), Expect = 2e-04
Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 36/195 (18%)
Query: 727 LDEVNLASCQLDPAGLRTLLPVFLRAR---KLGLQLNSLGPEACKDLRDLLLHDQCQITT 783
L ++ L SC L A + L V + +L + N+LG L + + QC +
Sbjct: 772 LKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQK 831
Query: 784 LRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLEL----------------- 826
L L N+ LT+ + L L+ N ++THL L LGD+G++L
Sbjct: 832 LGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
Query: 827 ------------LAAQLDRNRQLQELNVAYNGAGDTAALALARAAREH----PSLELLHL 870
L+ L ++ L++L++ N GD + ++ +L L +
Sbjct: 892 DNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEM 951
Query: 871 YFNELSSEGRQVLRD 885
YFN + + L++
Sbjct: 952 YFNYETKSALETLQE 966
Score = 44.3 bits (103), Expect = 6e-04
Identities = 47/173 (27%), Positives = 75/173 (43%), Gaps = 4/173 (2%)
Query: 715 VVAAVLGSGRHALDEVNLASCQLDPA---GLRTLLPVFLRARKLGLQLNSLGPEACKDLR 771
+V VL S HA L C L + +L + +L L N+LG + L
Sbjct: 703 MVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 762
Query: 772 DLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL 831
L H C + L L + LT+A L L+ + S+T L + LGD G+ +L +
Sbjct: 763 VGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKA 822
Query: 832 DRNR-QLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
+ LQ+L + +G AL+ + +L L+L N L +G ++L
Sbjct: 823 KNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL 875
Score = 41.6 bits (96), Expect = 0.004
Identities = 53/207 (25%), Positives = 84/207 (40%), Gaps = 32/207 (15%)
Query: 694 VLSSLRQLNLAGVRMTPVKCTVVAAVLGS---------GRHALDEVNLA---------SC 735
+L +L++L L +T C +A+VL + G +AL + +A C
Sbjct: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
Query: 736 QLDPAGL-------------RTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQIT 782
L GL ++L L L+ N+LG + K L + LLH C++
Sbjct: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
Query: 783 TLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL-DRNRQLQELN 841
L L N LT+ L L + S+ LSL + LGD G+ + L ++ LQ L
Sbjct: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
Query: 842 VAYNGAGDTAALALARAAREHPSLELL 868
++ AL E P L ++
Sbjct: 948 LSEMYFNYETKSALETLQEEKPELTVV 974
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 100 bits (250), Expect = 5e-21
Identities = 106/413 (25%), Positives = 183/413 (44%), Gaps = 60/413 (14%)
Query: 138 QAGLPPLALSQLFNPD-ACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELL 194
++ + P+ + LF+PD V TVV G G GK+ L RKM+LDW G L F+ L
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 195 IPFSCEDLS-----SLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
C ++S SLG S C P+ +++ S +LF++ G + L
Sbjct: 257 FYIHCREVSLVTQRSLGDLIMSCCP---DPNPPIHKIV----RKPSRILFLMDGFDELQG 309
Query: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKY-VGRYGE 308
F LC+D ++ + ++ +L+RK +LP+AS+L+TTRP A+ ++ R+ E
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 309 ICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAAC 368
I GFS+ ++ +F+ ++ AQ ++ N + C
Sbjct: 370 ILGFSEAKRKEYFFKYFSDE----------------AQARAAFSLIQEN----EVLFTMC 409
Query: 369 FLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAA 426
F+P CW+VC L +G++L TS T+ + + F L S +
Sbjct: 410 FIPLVCWIVCTG---LKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHL 466
Query: 427 RTMGKLAYEGVSSRKTYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
+ LA +G+ ++K F E D+ G +A + F +++F+++ C +
Sbjct: 467 WGLCSLAADGIWNQKILFEESDLRNHGLQKADV---SAFLRMNLFQKE------VDCEK- 516
Query: 485 GRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVL 537
+ F QE+ AA+Y +L K V +L R DV+++L
Sbjct: 517 ----FYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSR---DVTVLL 562
Score = 45.8 bits (107), Expect = 2e-04
Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 36/195 (18%)
Query: 727 LDEVNLASCQLDPAGLRTLLPVFLRAR---KLGLQLNSLGPEACKDLRDLLLHDQCQITT 783
L ++ L SC L A + L V + +L + N+LG L + + QC +
Sbjct: 829 LKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQK 888
Query: 784 LRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLEL----------------- 826
L L N+ LT+ + L L+ N ++THL L LGD+G++L
Sbjct: 889 LGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 948
Query: 827 ------------LAAQLDRNRQLQELNVAYNGAGDTAALALARAAREH----PSLELLHL 870
L+ L ++ L++L++ N GD + ++ +L L +
Sbjct: 949 DNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEM 1008
Query: 871 YFNELSSEGRQVLRD 885
YFN + + L++
Sbjct: 1009 YFNYETKSALETLQE 1023
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/215 (23%), Positives = 87/215 (40%), Gaps = 36/215 (16%)
Query: 703 LAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVF----LRARKLGLQ 758
L +T C + +VL + + +L E++L+ L G+R L R+L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQ-SLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLG 778
Query: 759 LNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGL--------------- 803
L E C D+ L+L ++ L LS+N L G+ +L GL
Sbjct: 779 RCGLSHECCFDI-SLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSC 837
Query: 804 --------------AGNTSVTHLSLLHTGLGDEGLELLAAQLDRNR-QLQELNVAYNGAG 848
+ + S+T L + LGD G+ +L + + LQ+L + +G
Sbjct: 838 CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
Query: 849 DTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
AL+ + +L L+L N L +G ++L
Sbjct: 898 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL 932
Score = 41.6 bits (96), Expect = 0.004
Identities = 53/207 (25%), Positives = 84/207 (40%), Gaps = 32/207 (15%)
Query: 694 VLSSLRQLNLAGVRMTPVKCTVVAAVLGS---------GRHALDEVNLA---------SC 735
+L +L++L L +T C +A+VL + G +AL + +A C
Sbjct: 825 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
Query: 736 QLDPAGL-------------RTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQIT 782
L GL ++L L L+ N+LG + K L + LLH C++
Sbjct: 885 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
Query: 783 TLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL-DRNRQLQELN 841
L L N LT+ L L + S+ LSL + LGD G+ + L ++ LQ L
Sbjct: 945 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Query: 842 VAYNGAGDTAALALARAAREHPSLELL 868
++ AL E P L ++
Sbjct: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
Score = 39.7 bits (91), Expect = 0.014
Identities = 36/120 (30%), Positives = 49/120 (40%), Gaps = 3/120 (2%)
Query: 715 VVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRAR---KLGLQLNSLGPEACKDLR 771
+V VL S HA L + L + R L V ++ +L L NSLG + L
Sbjct: 703 MVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLC 762
Query: 772 DLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL 831
+ L H C I L L L+ + L+ N + L L LGD G+ LL L
Sbjct: 763 ETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGL 822
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 100 bits (250), Expect = 5e-21
Identities = 106/413 (25%), Positives = 183/413 (44%), Gaps = 60/413 (14%)
Query: 138 QAGLPPLALSQLFNPD-ACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELL 194
++ + P+ + LF+PD V TVV G G GK+ L RKM+LDW G L F+ L
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 195 IPFSCEDLS-----SLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
C ++S SLG S C P+ +++ S +LF++ G + L
Sbjct: 257 FYIHCREVSLVTQRSLGDLIMSCCP---DPNPPIHKIV----RKPSRILFLMDGFDELQG 309
Query: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKY-VGRYGE 308
F LC+D ++ + ++ +L+RK +LP+AS+L+TTRP A+ ++ R+ E
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 309 ICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAAC 368
I GFS+ ++ +F+ ++ AQ ++ N + C
Sbjct: 370 ILGFSEAKRKEYFFKYFSDE----------------AQARAAFSLIQEN----EVLFTMC 409
Query: 369 FLPSYCWLVCATLHFLHAPTPAGQTL--TSIYTSFLRLNFSGETLDSTDPSNLSLMAYAA 426
F+P CW+VC L +G++L TS T+ + + F L S +
Sbjct: 410 FIPLVCWIVCTG---LKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHL 466
Query: 427 RTMGKLAYEGVSSRKTYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEP 484
+ LA +G+ ++K F E D+ G +A + F +++F+++ C +
Sbjct: 467 WGLCSLAADGIWNQKILFEESDLRNHGLQKADV---SAFLRMNLFQKE------VDCEK- 516
Query: 485 GRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVL 537
+ F QE+ AA+Y +L K V +L R DV+++L
Sbjct: 517 ----FYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSR---DVTVLL 562
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/207 (23%), Positives = 82/207 (39%), Gaps = 36/207 (17%)
Query: 715 VVAAVLGSGRHALDEVNLASCQLDPA---GLRTLLPVFLRARKLGLQLNSLGPEACKDLR 771
+V VL S HA L C L + +L + +L L N+LG + L
Sbjct: 703 MVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 762
Query: 772 DLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLEL----- 826
L H C + L L N+ LT+ + L L+ N ++THL L LGD+G++L
Sbjct: 763 VGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL 822
Query: 827 ------------------------LAAQLDRNRQLQELNVAYNGAGDTAALALARAAREH 862
L+ L ++ L++L++ N GD + ++
Sbjct: 823 LHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQ 882
Query: 863 ----PSLELLHLYFNELSSEGRQVLRD 885
+L L +YFN + + L++
Sbjct: 883 SCLLQNLGLSEMYFNYETKSALETLQE 909
Score = 41.6 bits (96), Expect = 0.004
Identities = 45/176 (25%), Positives = 76/176 (43%), Gaps = 27/176 (15%)
Query: 694 VLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRAR 753
+L +L++L L +T V C+ +++VL + ++ L ++LR
Sbjct: 768 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQN-------------------LTHLYLRG- 807
Query: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
N+LG + K L + LLH C++ L L N LT+ L L + S+ LS
Sbjct: 808 ------NTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 861
Query: 814 LLHTGLGDEGLELLAAQL-DRNRQLQELNVAYNGAGDTAALALARAAREHPSLELL 868
L + LGD G+ + L ++ LQ L ++ AL E P L ++
Sbjct: 862 LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVV 917
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 100 bits (249), Expect = 7e-21
Identities = 87/323 (26%), Positives = 147/323 (45%), Gaps = 41/323 (12%)
Query: 144 LALSQLFNP-DACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPA-FELLIPFSCED 201
+AL +LF P + + G G GK+TLVR V W +G++ F L++P + D
Sbjct: 122 VALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRD 181
Query: 202 LSSLGPAPASLC--QLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLC 259
L++ LC +L+ + + E L A + L +L GL+ + T C
Sbjct: 182 LNT----HEKLCADRLICSVFPHVGEP-SLAVAVPARALLILDGLDECRTPLDFSNTVAC 236
Query: 260 SDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQK 319
+DP++ +I N++R + P+ SI +T+RPSA G+IP V R EI GF++ ++
Sbjct: 237 TDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKV 296
Query: 320 LYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCA 379
Q+ P + L MLS+ ++ + C +P++C L
Sbjct: 297 CLEQM------------------FPEDQALLGWMLSQ-VQADRALYLMCTVPAFCRLTGM 337
Query: 380 TLHFLHAPTPAGQ--------TLTSIYTSFLRLNFSGETLDSTDPS-NLSLMAYAAR--- 427
L L Q TL +Y+ + R+ SGE + S + +A+ R
Sbjct: 338 ALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMV 397
Query: 428 -TMGKLAYEGVSSRKTYFSEEDV 449
T+G+LA+ G+ +K F E+D+
Sbjct: 398 GTLGRLAFHGLLKKKYVFYEQDM 420
Score = 87.0 bits (214), Expect = 8e-17
Identities = 80/276 (28%), Positives = 123/276 (44%), Gaps = 15/276 (5%)
Query: 616 EDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPP--- 672
ED ++F F+ GLLS A+LA +L A QA + ++ +L + L P
Sbjct: 506 EDGRLDVFLRFLSGLLSPRVNALLAG------SLLAQGEHQAYRTQVAELLQGCLRPDAA 559
Query: 673 --SELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMT-PVKCTVVAAVLGSGRHALDE 729
+ ++ L +E Q+ + V ++ LA R+T P +A +L E
Sbjct: 560 VCARAINVLHCLHELQHTELARSVEEAMESGALA--RLTGPAHRAALAYLLQVSDACAQE 617
Query: 730 VNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNN 789
NL S L L++LLP L RKL L N + L +L C+I + L+ N
Sbjct: 618 ANL-SLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAEN 676
Query: 790 PLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGD 849
++ G L L N S+T L L +G +G + LA L NR L L++ N D
Sbjct: 677 QISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRD 736
Query: 850 TAALALARAAREHPSLELLHLYFNELSSEGRQVLRD 885
A ++A A + +L +LHL N + G Q + D
Sbjct: 737 DGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMAD 772
Score = 77.4 bits (189), Expect = 6e-14
Identities = 60/197 (30%), Positives = 94/197 (47%), Gaps = 6/197 (3%)
Query: 715 VVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKL---GLQLNSLGPEACKDLR 771
++ +VL + +++LA Q+ G + L L R L L+ NS+GP+ K L
Sbjct: 656 LLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALA 715
Query: 772 DLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQL 831
D L ++ +T+L L N + G + E LA N +++ L L +G G + +A L
Sbjct: 716 DALKINRT-LTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADAL 774
Query: 832 DRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAE 891
+NR L+EL + N GD A ALA A + + LE L L N +S G L +G
Sbjct: 775 KQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAAL--MGALCT 832
Query: 892 GGARVVVSLTEGTAVSE 908
+ +SL E + E
Sbjct: 833 NQTLLSLSLRENSISPE 849
Score = 72.0 bits (175), Expect = 3e-12
Identities = 99/362 (27%), Positives = 148/362 (40%), Gaps = 29/362 (8%)
Query: 637 AVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSEL--LDHLFFHYEFQNQRFSAEV 694
+VL+ C I+ + EN Q K L R +L L LD Q + A+
Sbjct: 659 SVLSGKDCRIQKISLAEN-QISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADA 717
Query: 695 LS---SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLR 751
L +L L+L G + +A L S R L ++L + P G + + +
Sbjct: 718 LKINRTLTSLSLQGNTVRDDGARSMAEALASNR-TLSMLHLQKNSIGPMGAQRMADALKQ 776
Query: 752 ARKLG---LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTS 808
R L NS+G K L + L +Q + +L L +N ++ AGVA LM L N +
Sbjct: 777 NRSLKELMFSSNSIGDGGAKALAEALKVNQ-GLESLDLQSNSISDAGVAALMGALCTNQT 835
Query: 809 VTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELL 868
+ LSL + EG + +A L N L+ L++ N D A A+A A RE+ +L L
Sbjct: 836 LLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSL 895
Query: 869 HLYFNELSSEGRQVL------------RDLGGAA---EGGARVVVSLTEGTAVSEYWSVI 913
HL +N + + Q L DL A +G V +L TA++ + +
Sbjct: 896 HLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQV 955
Query: 914 LSEVQRNLNSWDRA-RVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGS 972
S A V R LE+L DL + A L+V +R L Q S
Sbjct: 956 ASIGASGAQVLGEALAVNRTLEIL--DLRGNAIGVAGAKALANALKVNSSLRRLNLQENS 1013
Query: 973 SG 974
G
Sbjct: 1014 LG 1015
Score = 34.3 bits (77), Expect = 0.58
Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 755 LGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSL 814
L L+ N++G K L + L + + L L N L G + L+GN + H++L
Sbjct: 979 LDLRGNAIGVAGAKALANALKVNS-SLRRLNLQENSLGMDGAICIATALSGNHRLQHINL 1037
Query: 815 LHTGLGDEGLELLAAQLDRN 834
+GD G +++ + N
Sbjct: 1038 QGNHIGDSGARMISEAIKTN 1057
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 95.5 bits (236), Expect = 2e-19
Identities = 92/377 (24%), Positives = 163/377 (43%), Gaps = 52/377 (13%)
Query: 143 PLALSQLFNPDA-CGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELLIPFSC 199
P+ + LF PD +TVV+ G G GKS L K++LDW G+L F+ L +C
Sbjct: 193 PIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINC 252
Query: 200 EDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLC 259
+++ S+ L+ + L + LLF++ G + L F C
Sbjct: 253 REMNQ-SATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
Query: 260 SDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYV-GRYGEICGFSDTNLQ 318
EE + ++ +L+RK +LP+ S+L+TTRP+A+ ++ R+ EI GFS+ +
Sbjct: 312 LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
Query: 319 KLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVC 378
+ +++ N G + + + + CF+P CW+VC
Sbjct: 372 EYFYKYFHNAEQAG--------------------QVFNYVRDNEPLFTMCFVPLVCWVVC 411
Query: 379 ATLHFL----HAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYA-ARTMGKLA 433
L +T T++Y +L +L P L R + LA
Sbjct: 412 TCLQQQLEGGGLLRQTSRTTTAVYMLYLL------SLMQPKPGAPRLQPPPNQRGLCSLA 465
Query: 434 YEGVSSRKTYFSEEDVCGCLEAGIRTEE--EFQLLHIFRRDALRFFLAPCVEPGRAGTFV 491
+G+ ++K F E+D+ + G+ E+ F ++IF++D + R +F+
Sbjct: 466 ADGLWNQKILFEEQDL---RKHGLDGEDVSAFLNMNIFQKD---------INCERYYSFI 513
Query: 492 FTVPAMQEYLAALYIVL 508
+ QE+ AA+Y +L
Sbjct: 514 HL--SFQEFFAAMYYIL 528
Score = 51.6 bits (122), Expect = 4e-06
Identities = 55/189 (29%), Positives = 80/189 (42%), Gaps = 27/189 (14%)
Query: 698 LRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGL 757
L+ + L ++ C +A+VLG+ H L E++L L+ GLR L
Sbjct: 801 LQMIQLRKCQLESGACQEMASVLGTNPH-LVELDLTGNALEDLGLRLL------------ 847
Query: 758 QLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHT 817
C+ LR H C++ TL L LTAA L L+ N S+ L L
Sbjct: 848 ---------CQGLR----HPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLN 894
Query: 818 GLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELS 876
LGD G+ LL L +LQ L + G A L+ + + +L L L FN+L
Sbjct: 895 ELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLG 954
Query: 877 SEGRQVLRD 885
G +L +
Sbjct: 955 DWGLWLLAE 963
Score = 48.5 bits (114), Expect = 3e-05
Identities = 43/141 (30%), Positives = 63/141 (44%), Gaps = 3/141 (2%)
Query: 694 VLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPA---GLRTLLPVFL 750
V SLR+L+L+ + + ++ L L + L C+L A GL +L
Sbjct: 882 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANH 941
Query: 751 RARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVT 810
R+L L N LG L + L H C++ L L + LTA L L N ++T
Sbjct: 942 NLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLT 1001
Query: 811 HLSLLHTGLGDEGLELLAAQL 831
L L + LGD G+ LL +L
Sbjct: 1002 DLYLTNNALGDTGVRLLCKRL 1022
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/131 (27%), Positives = 57/131 (43%), Gaps = 1/131 (0%)
Query: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
+L L N+LG K L L H C++ LRL ++++ L L N ++T +
Sbjct: 717 ELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMD 776
Query: 814 LLHTGLGDEGLELLAAQLDRNR-QLQELNVAYNGAGDTAALALARAAREHPSLELLHLYF 872
L G+G G+ LL L + +LQ + + A +A +P L L L
Sbjct: 777 LSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTG 836
Query: 873 NELSSEGRQVL 883
N L G ++L
Sbjct: 837 NALEDLGLRLL 847
Score = 39.7 bits (91), Expect = 0.014
Identities = 49/204 (24%), Positives = 74/204 (36%), Gaps = 42/204 (20%)
Query: 727 LDEVNLASCQLDPAGLRTLLPVFLRARKL---GLQLNSLGPEACKDLRDLLLHDQCQITT 783
L + L C++ + L + + L L N +G L + L H QC++
Sbjct: 744 LQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQM 803
Query: 784 LRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLEL----------------- 826
++L L + + L N + L L L D GL L
Sbjct: 804 IQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWL 863
Query: 827 ------------LAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNE 874
LA+ L N+ L+EL+++ N GD L L R HP+ +L L
Sbjct: 864 KICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLR-HPTCKLQTL---- 918
Query: 875 LSSEGRQVLRDLGGAAEGGARVVV 898
R + LG AA G VV+
Sbjct: 919 -----RLGICRLGSAACEGLSVVL 937
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 94.0 bits (232), Expect = 6e-19
Identities = 94/373 (25%), Positives = 165/373 (44%), Gaps = 50/373 (13%)
Query: 146 LSQLFNPDA-CGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELLIPFSCEDL 202
L LF+ D G + Q VVL G G GK+TLVRK +LDW G L F+ + + ++
Sbjct: 162 LEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREI 221
Query: 203 SSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDP 262
+ L S QL+++ + + + + S LLF++ + LN F LC D
Sbjct: 222 NQL--KERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDW 279
Query: 263 EEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVG-RYGEICGFSDTNLQKLY 321
+ + ++ +LLRK MLP+AS+LVTTR + R+ Y E+ G S+ ++
Sbjct: 280 TQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYI 339
Query: 322 FQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATL 381
+Q ++ + + +L+ + + + C +P CW C L
Sbjct: 340 YQFFEDKRW--------------------AMKVFSSLKSNEMLFSMCQVPLVCWAACTCL 379
Query: 382 HFLHAP----TPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGV 437
T QT T+++T ++ F+ +D PS L A R + ++A +G+
Sbjct: 380 KQQMEKGGDVTLTCQTTTALFTCYISSLFT--PVDGGSPS-LPNQA-QLRRLCQVAAKGI 435
Query: 438 SSRKTYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVP 495
+ F E++ G ++ + F +I ++DA +VFT
Sbjct: 436 WTMTYVFYRENLRRLGLTQSDV---SSFMDSNIIQKDA-----------EYENCYVFTHL 481
Query: 496 AMQEYLAALYIVL 508
+QE+ AA++ +L
Sbjct: 482 HVQEFFAAMFYML 494
Score = 59.7 bits (143), Expect = 1e-08
Identities = 56/193 (29%), Positives = 84/193 (43%), Gaps = 4/193 (2%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLG 756
SL LNL+ + ++ L + L+ ++L SC L AG L + ++L
Sbjct: 787 SLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLT 846
Query: 757 ---LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
L N LG K + D L H QC + +L L T+ L L N S+THL
Sbjct: 847 HLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLD 906
Query: 814 LLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYF 872
L L D G++LL + LQ+L + + L LA +P+L L L
Sbjct: 907 LGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGN 966
Query: 873 NELSSEGRQVLRD 885
N+L +G ++L D
Sbjct: 967 NDLQDDGVKILCD 979
Score = 48.1 bits (113), Expect = 4e-05
Identities = 45/164 (27%), Positives = 73/164 (44%), Gaps = 4/164 (2%)
Query: 727 LDEVNLASCQLDPAGLRTLLPVFLRARKL---GLQLNSLGPEACKDLRDLLLHDQCQITT 783
L + L SC L + +R++ L L N+L + + L + L H +C +
Sbjct: 760 LQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLER 819
Query: 784 LRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNR-QLQELNV 842
L L + LT AG L L N +THL L LGD G++L++ L + L+ L +
Sbjct: 820 LSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVL 879
Query: 843 AYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDL 886
++ L+ + + SL L L N L G ++L D+
Sbjct: 880 RRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDV 923
Score = 43.9 bits (102), Expect = 7e-04
Identities = 47/157 (29%), Positives = 62/157 (39%), Gaps = 33/157 (21%)
Query: 755 LGLQLNSLGPEACKDLRDLLLHDQCQITTLR----------------------------L 786
L L+ + +G K L + L H +C++ TLR L
Sbjct: 734 LDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNL 793
Query: 787 SNNPLTAAGVAVLMEGLA-GNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYN 845
S N L GV +L E L + LSL GL + G E L+ L N++L L +A N
Sbjct: 794 STNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADN 853
Query: 846 GAGDTAAL----ALARAAREHPSLELLHLYFNELSSE 878
GD AL A SL L +F LSSE
Sbjct: 854 VLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSE 890
Score = 36.6 bits (83), Expect = 0.12
Identities = 36/132 (27%), Positives = 55/132 (41%), Gaps = 2/132 (1%)
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHL 812
R+L L ++L A L L H C++ L L G + L N ++ HL
Sbjct: 676 RELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDISTSLIHNKNLMHL 734
Query: 813 SLLHTGLGDEGLELLAAQLDRNR-QLQELNVAYNGAGDTAALALARAAREHPSLELLHLY 871
L + +GD G++ L L +LQ L + L ++ A SL L+L
Sbjct: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
Query: 872 FNELSSEGRQVL 883
N L +G Q+L
Sbjct: 795 TNNLLDDGVQLL 806
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 92.8 bits (229), Expect = 1e-18
Identities = 90/372 (24%), Positives = 162/372 (43%), Gaps = 49/372 (13%)
Query: 146 LSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLS 203
L +LF P G++ +TV++ G G GK+TL+ K+++ W ++ F F C +L
Sbjct: 135 LDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELR 194
Query: 204 SLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPE 263
L P SL L+++ + + + + LLFV+ E L + LC D
Sbjct: 195 EL--PPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLM 252
Query: 264 EPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKY-VGRYGEICGFSDTNLQKLYF 322
E + ++ +LLRK MLP+AS+L+ +P + + + + GF++++ + +YF
Sbjct: 253 EKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESD-RLVYF 311
Query: 323 QLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLH 382
P +R L R E Q+ + C +P CW++C +L
Sbjct: 312 CCFFKDP----------------KRAMEAFNLVRESE---QLFSICQIPLLCWILCTSLK 352
Query: 383 FLHAP----TPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVS 438
Q+ TS+Y+SF+ F+ E + P + + + LA EG+
Sbjct: 353 QEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQT----QHQLKALCSLAAEGMW 408
Query: 439 SRKTYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPA 496
+ F E+D+ G ++A I ++L + R ++VF
Sbjct: 409 TDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGE--------------RESSYVFLHVC 454
Query: 497 MQEYLAALYIVL 508
+QE+ AAL+ +L
Sbjct: 455 IQEFCAALFYLL 466
Score = 52.4 bits (124), Expect = 2e-06
Identities = 64/257 (24%), Positives = 103/257 (40%), Gaps = 32/257 (12%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRH---------------------------ALDE 729
++++L L ++P+ C V+A +L + + L
Sbjct: 724 NVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTVLVY 783
Query: 730 VNLASCQLDPAGLRTLLPVFLR---ARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRL 786
+ LA C L + + LR R L L N L E K L + L H C + +L L
Sbjct: 784 LMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCL 843
Query: 787 SNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYN 845
+TAAG L L N ++ L + +GD G++LL L + +L+ L +
Sbjct: 844 VKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEEC 903
Query: 846 GAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTA 905
G T LA +L+ L+L N L G VL + E A V+ L +
Sbjct: 904 GLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPE-CALQVLGLRKTDF 962
Query: 906 VSEYWSVILSEVQRNLN 922
E +++ +E +RN N
Sbjct: 963 DEETQALLTAEEERNPN 979
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 92.0 bits (227), Expect = 2e-18
Identities = 182/814 (22%), Positives = 313/814 (38%), Gaps = 132/814 (16%)
Query: 146 LSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLS 203
L +L +P+ + QT+VL G G GK+TL + +L W G L F + SC +
Sbjct: 215 LQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIR 274
Query: 204 SLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHL----NLDFRLAGTGLC 259
+ + +L++ + + + LLF++ G E + + L C
Sbjct: 275 YM--KETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPC 332
Query: 260 SDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGR-YGEICGFSDTNLQ 318
+D + I+ +LL+K ++P A++L+T + + + + V + +I GF+ +L
Sbjct: 333 TDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDL- 391
Query: 319 KLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVC 378
++YF + ++ + ++Q L +N H +C P CW VC
Sbjct: 392 RVYFMRHFDD---------------SSEVEKILQQLRKNETLFH----SCSAPMVCWTVC 432
Query: 379 ATL-------HFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGK 431
+ L + L + T QT TS+Y F FS +D D S R +
Sbjct: 433 SCLKQPKVRYYDLQSIT---QTTTSLYAYFFSNLFSTAEVDLADDS----WPGQWRALCS 485
Query: 432 LAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFV 491
LA EG+ S F++ED E + L + D+L F G
Sbjct: 486 LAIEGLWSMNFTFNKEDT------------EIEGLEVPFIDSLYEFNILQKINDCGGCTT 533
Query: 492 FTVPAMQEYLAALYIVLGLRKTTLQKVGK--EVAELVGRVGED--------VSLVLGIMA 541
FT + QE+ AA+ VL + K E+ L+ V D V G++
Sbjct: 534 FTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLN 593
Query: 542 KLLPLRALPLLFNLIKVVPRV------FGRMVGKSREAVAQAMVLEMFR-EEDYYNDDVL 594
K + L K+ PRV +G +GK+ A Q +L +F + +D
Sbjct: 594 KNIARELEDTLH--CKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFT 651
Query: 595 DQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALEN 654
+M I V+ EDE + + + + ++L+ LE
Sbjct: 652 KKMLGRIFEVD------LNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILET 705
Query: 655 AQ-AIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSL-----------RQLN 702
++ + L +E L L + N + A + L ++L
Sbjct: 706 SKFDSRMHAWNSICSTLVTNENLHEL----DLSNSKLHASSVKGLCLALKNPRCKVQKLT 761
Query: 703 LAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLD---PAGLRTLLPVFLRARKLGLQL 759
V V ++ A+ G+ + L +N +S +L P L+ L + L L+
Sbjct: 762 CKSVTPEWVLQDLIIALQGNSK--LTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEK 819
Query: 760 NSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAV--------------------- 798
+L +C+DL L L +T L L N L G+ +
Sbjct: 820 CNLSAASCQDLA-LFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQ 878
Query: 799 --------LMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGD 849
L + L N S+THL+L L DEG++ L L R + LQ LN++
Sbjct: 879 LAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTR 938
Query: 850 TAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
LA A + ++++L L N+L +G ++L
Sbjct: 939 EGCGELANALSHNHNVKILDLGENDLQDDGVKLL 972
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 84.3 bits (207), Expect = 5e-16
Identities = 96/372 (25%), Positives = 159/372 (42%), Gaps = 48/372 (12%)
Query: 146 LSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSL 205
L+ F+ D G R +TVVL+G G GKS L R++VL W G L F
Sbjct: 266 LAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQ 325
Query: 206 GPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEP 265
+S+ + +++ + + + + + LLF++ G + L T LC D E
Sbjct: 326 RKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLN-NDTKLCKDWAEK 384
Query: 266 QEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVG-RYGEICGFSDTNLQKLYFQL 324
Q P +I +LLRK +LP++ ++VT R ++ S+ V RY + G S Q+++ L
Sbjct: 385 QPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGE--QRIHLLL 442
Query: 325 RLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFL 384
G G +H R + + ++ C +P+ L+C L
Sbjct: 443 E----------RGIG--------EHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQ 484
Query: 385 ----HAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSL-MAYAARTMGKLAYEGVSS 439
+ P QTLT ++ +F+ F T L+L + ++A EGV +
Sbjct: 485 DVVGESVAPFNQTLTGLHAAFV---FHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWN 541
Query: 440 RKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAP---CVEPGRAGTFVFTVPA 496
RK+ F +D+ + G+ E L H+ L P C E + F +
Sbjct: 542 RKSVFDGDDL---MVQGLGESELRALFHM-------NILLPDSHCEE-----YYTFFHLS 586
Query: 497 MQEYLAALYIVL 508
+Q++ AALY VL
Sbjct: 587 LQDFCAALYYVL 598
Score = 57.0 bits (136), Expect = 8e-08
Identities = 47/180 (26%), Positives = 73/180 (40%), Gaps = 9/180 (5%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPA---GLRTLLPVFLRAR 753
+LR LNL G + + L + L+ + L C L A + +L +
Sbjct: 838 NLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLK 897
Query: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
L L N + + L D L QC + L L + +TA G L L N S+THL
Sbjct: 898 SLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLC 957
Query: 814 LLHTGLGDEGLELLAAQLD------RNRQLQELNVAYNGAGDTAALALARAAREHPSLEL 867
L + LG+EG+ LL + + L + ++ G G A + + H SL +
Sbjct: 958 LSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSM 1017
Score = 57.0 bits (136), Expect = 8e-08
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 32/201 (15%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLG 756
SL+ L+LAG ++T ++ L + AL ++ L C + G ++L + R L
Sbjct: 895 SLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLT 954
Query: 757 ---LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
L NSLG E L + C + L L+ L AG L L GN+ +THLS
Sbjct: 955 HLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLS 1014
Query: 814 LLHTGLGDEGLEL-----------------------------LAAQLDRNRQLQELNVAY 844
L + D G++L L+ + R+R L+ L++
Sbjct: 1015 LSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTD 1074
Query: 845 NGAGDTAALALARAAREHPSL 865
N GD AL ++ S+
Sbjct: 1075 NALGDGGVAALCEGLKQKNSV 1095
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/196 (26%), Positives = 86/196 (43%), Gaps = 8/196 (4%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVF----LRA 752
SL++L L + C +A L G L ++L+ ++ G++ L V
Sbjct: 981 SLQRLMLNQCHLDTAGCGFLALAL-MGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHL 1039
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSV-TH 811
+ L L L C+ L ++ + + +L L++N L GVA L EGL SV
Sbjct: 1040 QDLELVKCHLTAACCESLSCVISRSR-HLKSLDLTDNALGDGGVAALCEGLKQKNSVLAR 1098
Query: 812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARA-AREHPSLELLHL 870
L L GL + E L+ L NR L LN+ N + L A A +L+++ L
Sbjct: 1099 LGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
Query: 871 YFNELSSEGRQVLRDL 886
+ + + R++L ++
Sbjct: 1159 WKWQYPVQIRKLLEEV 1174
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 82.8 bits (203), Expect = 1e-15
Identities = 94/385 (24%), Positives = 154/385 (40%), Gaps = 47/385 (12%)
Query: 136 PPQAGLPPLALSQLFN-PDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGR-LPAFEL 193
PPQ L L +LF+ P TV++ G G+GKSTL++++ L W G+ F
Sbjct: 268 PPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLF 327
Query: 194 LIPFSCEDLSSLGPAPASLCQLVAQRY----TPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
+ PFSC L + P S+ L+ + +++ L+ +L G +
Sbjct: 328 VFPFSCRQLQCMAK-PLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFK- 385
Query: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEI 309
FR P +P ++ NLL+ +L A +VT+RP+A+ KY+ +
Sbjct: 386 -FRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNL 444
Query: 310 CGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACF 369
GFS+ ++ LY + R ++P GV+ D L+++L H C
Sbjct: 445 KGFSEQGIE-LYLRKRHHEP---------GVA------DRLIRLLQETSALH----GLCH 484
Query: 370 LPSYCWLVC-ATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAART 428
LP + W+V L + +T T +Y L+ T + L R
Sbjct: 485 LPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRL 544
Query: 429 -----MGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVE 483
+G+LA G+ FS + L+A + ++ L + R A V
Sbjct: 545 PTLLHLGRLALWGLGMCCYVFSAQQ----LQAAQVSPDDISLGFLVR--------AKGVV 592
Query: 484 PGRAGTFVFTVPAMQEYLAALYIVL 508
PG F Q + AA Y+ L
Sbjct: 593 PGSTAPLEFLHITFQCFFAAFYLAL 617
Score = 77.0 bits (188), Expect = 8e-14
Identities = 76/270 (28%), Positives = 116/270 (42%), Gaps = 38/270 (14%)
Query: 683 YEFQNQRFSAEVLSSLRQLNLAGVRMT-----PVKCTVVAAVLGSGRHALDEVNLASCQL 737
YE Q +R + + + R LN+ +++T P +C +A VL R + + L +
Sbjct: 747 YEMQEERLARK---AARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPV-ALQLDYNSV 802
Query: 738 DPAGLRTLLPVFLRARKLGLQLNSLGPEA----------CKDLRDLLLH-----DQC--- 779
G+ LLP + L L+ N++ C+ L+ L L D C
Sbjct: 803 GDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHS 862
Query: 780 ---------QITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQ 830
LRL NN +TAAG VL EGL GNTS+ L +GDEG + LA
Sbjct: 863 MAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEA 922
Query: 831 LDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAA 890
L ++ L+ L++ N G A ALA ++ LE L L N L EG L + G
Sbjct: 923 LGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAE--GLK 980
Query: 891 EGGARVVVSLTEGTAVSEYWSVILSEVQRN 920
+ + ++ L+ +L ++RN
Sbjct: 981 KNSSLKILKLSNNCITYLGAEALLQALERN 1010
Score = 35.4 bits (80), Expect = 0.26
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 1/88 (1%)
Query: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHL 812
R L L N++G + L L+L + L L N L GV L EGL N+S+ L
Sbjct: 930 RWLSLVGNNIGSVGAQALA-LMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKIL 988
Query: 813 SLLHTGLGDEGLELLAAQLDRNRQLQEL 840
L + + G E L L+RN + E+
Sbjct: 989 KLSNNCITYLGAEALLQALERNDTILEV 1016
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 82.8 bits (203), Expect = 1e-15
Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 57/305 (18%)
Query: 162 VVLYGTVGTGKSTLVRKMVLDWCYGRL--PAFELLIPFSCEDLSSLGPAPASLCQLV--- 216
VVL G+ GTGK+TL RKMVLDW G L F+ + SC+++ L + L QL+
Sbjct: 169 VVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLL--LESKLEQLLFWC 226
Query: 217 -AQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDF--RLAGTGLCSDPEEPQEPAAIIV 273
P+ E+L LLF+L G + L F +L GL P+E +++
Sbjct: 227 CGDNQAPVTEIL----RQPERLLFILDGFDELQRPFEEKLKKRGL--SPKE-----SLLH 275
Query: 274 NLLRKYMLPQASILVTTRPSAIGRI-PSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCG 332
L+R++ LP S+L+TTRP A+ + P R+ I GFS+ + +
Sbjct: 276 LLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYF----------- 324
Query: 333 YAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLH--------FL 384
S Q D ++ +N + AC +P CW+VC+ L L
Sbjct: 325 -----SSYFTDEKQADRAFDIVQKN----DILYKACQVPGICWVVCSWLQGQMERGKVVL 375
Query: 385 HAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYF 444
P + + ++FL + D S LS R++ LA EG+ ++ F
Sbjct: 376 ETPRNSTDIFMAYVSTFLPPD------DDGGCSELS-RHRVLRSLCSLAAEGIQHQRFLF 428
Query: 445 SEEDV 449
E ++
Sbjct: 429 EEAEL 433
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 72.8 bits (177), Expect = 1e-12
Identities = 80/302 (26%), Positives = 126/302 (41%), Gaps = 40/302 (13%)
Query: 158 RVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVA 217
R TVVL G G GK+TL+RK++LDW G L F G A SL +L++
Sbjct: 144 RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLS 203
Query: 218 QRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLR 277
+ + E + + + +LF++ G E L + +L L D + Q I+ +LL+
Sbjct: 204 RDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQLK-ADLSDDWRQRQPMPIILSSLLQ 262
Query: 278 KYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGG 337
K MLP++S+L+ A+G++ +QK YF LR P +G
Sbjct: 263 KKMLPESSLLI-----ALGKLA-----------------MQKHYFMLR--HPKLIKLLGF 298
Query: 338 SGVSATPAQRDHLVQMLSRNLE------GHHQIAAACFLPSYCWLVCA----TLHFLHAP 387
S S + + S+ L+ + + C P CWLVC L
Sbjct: 299 S-ESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDL 357
Query: 388 TPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEE 447
Q T +Y SFL F + N + + +++ LA EG+ + FS
Sbjct: 358 EINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARL----KSLCALAAEGIWTYTFVFSHG 413
Query: 448 DV 449
D+
Sbjct: 414 DL 415
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/126 (28%), Positives = 54/126 (42%), Gaps = 1/126 (0%)
Query: 755 LGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSL 814
L L SL + L + L H C+I L L +++ + LA N+ + HLSL
Sbjct: 690 LSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSL 749
Query: 815 LHTGLGDEGLELLAAQLDRNR-QLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFN 873
+ L DEG+ LL L + L+ L + Y + +++ SL LL L N
Sbjct: 750 VENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSN 809
Query: 874 ELSSEG 879
L G
Sbjct: 810 ALEDNG 815
Score = 37.0 bits (84), Expect = 0.090
Identities = 39/141 (27%), Positives = 56/141 (39%), Gaps = 7/141 (4%)
Query: 696 SSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKL 755
S L+ L+L + T++ L AL+ + L C L ++ V L ++ L
Sbjct: 742 SKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSL 801
Query: 756 GLQLNSLGPEACKD-----LRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVT 810
L LG A +D L L H C I L L LT+ + L N +
Sbjct: 802 SLL--DLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
Query: 811 HLSLLHTGLGDEGLELLAAQL 831
L L H +GD G+ L A L
Sbjct: 860 TLKLGHNEIGDTGVRQLCAAL 880
Score = 35.8 bits (81), Expect = 0.20
Identities = 40/185 (21%), Positives = 76/185 (41%), Gaps = 7/185 (3%)
Query: 692 AEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRH---ALDEVNLASCQLDPAGLRTLLPV 748
+EVL + L+L + ++ VA++ + +H ++ E+ L C L + + V
Sbjct: 792 SEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAV 851
Query: 749 FL---RARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAG 805
+ + + L L N +G + L L H C++ L L P+T A + L
Sbjct: 852 LICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIA 911
Query: 806 NTSVTHLSLLHTGLGDEGLELLAAQLDR-NRQLQELNVAYNGAGDTAALALARAAREHPS 864
++ L+L L + + +L L + LQ L + +G + L + P
Sbjct: 912 CKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPH 971
Query: 865 LELLH 869
L + H
Sbjct: 972 LTISH 976
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 72.8 bits (177), Expect = 1e-12
Identities = 103/443 (23%), Positives = 177/443 (39%), Gaps = 79/443 (17%)
Query: 76 TEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQ 135
T A QR+R S++P G A V+V P++R +T L P +
Sbjct: 153 TSAQQRYR-------SQIPGS----GQPHAFHQVYVPPILRRATAS--LDTPEGAIMGDV 199
Query: 136 PPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLI 195
+ G +++S LFN + + VL G G GK+TL ++ W G L F+ L
Sbjct: 200 KVEDGAD-VSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALF 257
Query: 196 PFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAG 255
F L+ L+ + TP + + L + S V LE L
Sbjct: 258 LFEFRQLN-----------LITRFLTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIF 306
Query: 256 TGL--CSDPEEPQEPAAIIV---NLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYG--E 308
GL P P P ++ +L +LP ++ T+RP G++P+
Sbjct: 307 DGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRP---GKLPACLPAEAAMVH 363
Query: 309 ICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAAC 368
+ GF +++ SA P++ LV+ L+ + ++ + C
Sbjct: 364 MLGFDGPRVEEYVNHF---------------FSAQPSREGALVE-----LQTNGRLRSLC 403
Query: 369 FLPSYCWLVCATLHFL---HAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYA 425
+P+ C + C LH L HAP + L ++ ++++ L + P +L +
Sbjct: 404 AVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQM-----VLALSPPGHLPTSSLL 458
Query: 426 ARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPG 485
+G++A G+ + K F +D+ L A F H +L C PG
Sbjct: 459 --DLGEVALRGLETGKVIFYAKDIAPPLIA-------FGATH-----SLLTSFCVCTGPG 504
Query: 486 RAGT-FVFTVPAMQEYLAALYIV 507
T + FT ++QE+LAAL+++
Sbjct: 505 HQQTGYAFTHLSLQEFLAALHLM 527
Score = 57.0 bits (136), Expect = 8e-08
Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 35/216 (16%)
Query: 695 LSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARK 754
LS L+ L ++ +A+ LG H L+E++L++ Q D G + L+ L +
Sbjct: 1493 LSELKTFRLTSSCVSTEGLAHLASGLGHCHH-LEELDLSNNQFDEEGTKALMRA-LEGKW 1550
Query: 755 LGLQLNSLGPEACKDLRDLLLHDQCQIT---TLRLSNNPLTAAGVAVLMEGLAGNTSVTH 811
+ +L+ LL H Q+T +LRL+ N + G L E L TS+
Sbjct: 1551 MLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
Query: 812 LSLLHTGLGDEGLELLAA------------------------QLDRN----RQLQELNVA 843
L L H +GD G++ LA QL + R+L+EL +
Sbjct: 1611 LDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLG 1670
Query: 844 YNGAGDTAALALARAAREHPSLELLHLYFNELSSEG 879
N GD AL LA+ +H L +LHL F+ L G
Sbjct: 1671 CNALGDPTALGLAQELPQH--LRVLHLPFSHLGPGG 1704
Score = 55.8 bits (133), Expect = 2e-07
Identities = 51/161 (31%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 726 ALDEVNLASCQLDPAG---LRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQIT 782
+L +VNL C+ D A L++LL + L + + E L L H +
Sbjct: 1469 SLSQVNL--CEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCH-HLE 1525
Query: 783 TLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNV 842
L LSNN G LM L G + L L H L L LL +L + LQ L +
Sbjct: 1526 ELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRL 1585
Query: 843 AYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
N GD L+ A R SLE L L N++ G Q L
Sbjct: 1586 NRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHL 1626
Score = 38.5 bits (88), Expect = 0.031
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
+L L N +G + L +L ++ + LS N +++AG L E L + L
Sbjct: 1610 ELDLSHNQIGDAGVQHLATIL-PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELM 1668
Query: 814 LLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFN 873
L LGD LA +L ++ L+ L++ ++ G AL+LA+A P LE + L N
Sbjct: 1669 LGCNALGDPTALGLAQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAEN 1726
Query: 874 ELS 876
L+
Sbjct: 1727 NLA 1729
Score = 38.1 bits (87), Expect = 0.040
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 4/110 (3%)
Query: 727 LDEVNLASCQLDPAGLRTLLPVFLRARKLGLQL---NSLGPEACKDLRDLLLHDQCQITT 783
L +++L SC++D + L F L + L N LG EA +L +L ++
Sbjct: 1742 LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL-PQMGRLKR 1800
Query: 784 LRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDR 833
+ L N +TA G +L EGLA +S+ + L + + + + L +Q R
Sbjct: 1801 VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPR 1850
Score = 37.7 bits (86), Expect = 0.053
Identities = 28/76 (36%), Positives = 38/76 (50%), Gaps = 2/76 (2%)
Query: 784 LRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTG--LGDEGLELLAAQLDRNRQLQELN 841
+RL++ L + L + L G+ + HL L +G LGDEG LA L LQ LN
Sbjct: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQSLN 1038
Query: 842 VAYNGAGDTAALALAR 857
++ NG A L L R
Sbjct: 1039 LSENGLSLDAVLGLVR 1054
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 72.0 bits (175), Expect = 3e-12
Identities = 87/369 (23%), Positives = 154/369 (41%), Gaps = 63/369 (17%)
Query: 156 GRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFE--LLIPFSCEDLSSLGPAPASLC 213
GR+ +TV + G G GK+ L +K++ +W + A + F C++++ S
Sbjct: 200 GRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQ--TTDQSFS 257
Query: 214 QLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIV 273
+L+ Q++ ++++ + + LL +L G E L L D + + ++
Sbjct: 258 ELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLS 317
Query: 274 NLLRKYMLPQASILVTTRPSA------IGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLN 327
+LL K MLP+A++L+ R ++ + + PS + GF+ K YFQ+
Sbjct: 318 SLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVT-----LPGFNTMEKIK-YFQM--- 368
Query: 328 QPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFL--- 384
Y G+ G V + + L M C +P CW+VC+ L
Sbjct: 369 --YFGHTEEGDQVLSFAMENTILFSM--------------CRVPVVCWMVCSGLKQQMER 412
Query: 385 -HAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMG--KLAYEGVSSRK 441
+ T + TS++ ++ +L T N S + A+ G LA + + RK
Sbjct: 413 GNNLTQSCPNATSVFVRYI------SSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRK 466
Query: 442 TYFSEEDV--CGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQE 499
+ED+ + G+ F + I RR A G +VFT+ QE
Sbjct: 467 WVLGKEDLEEAKLDQTGVTA---FLGMSILRRIA-----------GEEDHYVFTLVTFQE 512
Query: 500 YLAALYIVL 508
+ AAL+ VL
Sbjct: 513 FFAALFYVL 521
Score = 33.1 bits (74), Expect = 1.3
Identities = 50/191 (26%), Positives = 74/191 (38%), Gaps = 20/191 (10%)
Query: 698 LRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDP---AGLRTLLPVFLRARK 754
LR L + V + ++ VL S R L + L C P L L +
Sbjct: 761 LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKT 820
Query: 755 LGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSL 814
L L+ NSL E C Q+ L + N LT L L + +THLSL
Sbjct: 821 LILRKNSL--ENC----GAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSL 874
Query: 815 LHTGLGDEGLELLAAQLDRNR------QLQELNVAYNGAGDTAALALARAAREHPSLELL 868
L DEG + + L R L++ ++ +N D + A ++ +L+ L
Sbjct: 875 AENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQD-----MISALCKNKTLKSL 929
Query: 869 HLYFNELSSEG 879
L FN L +G
Sbjct: 930 DLSFNSLKDDG 940
>gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain
and proline-rich containing [Homo sapiens]
Length = 1435
Score = 57.0 bits (136), Expect = 8e-08
Identities = 55/221 (24%), Positives = 94/221 (42%), Gaps = 38/221 (17%)
Query: 697 SLRQLNLAGVRMTPVKCTVVAAVLGSGRHALD-EVNLASCQLDPAGLRTLLPVFLRA--- 752
+LR L LAG ++ P + L H D ++L++C+L AG + + + A
Sbjct: 463 TLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAV 522
Query: 753 RKLGLQLNSLGPEA-------------------------CKDLRDLLLH--------DQC 779
L L N G + CK+ D +LH D C
Sbjct: 523 SSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDC 582
Query: 780 QITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQE 839
+ +L ++ + L G +VL+ LA N ++T L + +GD G +LLA L N +L+
Sbjct: 583 PLQSLSVAESRLKL-GASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRS 641
Query: 840 LNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGR 880
+ N L +A+A ++ SL+ + L N+++ R
Sbjct: 642 VVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQR 682
Score = 37.7 bits (86), Expect = 0.053
Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 2/108 (1%)
Query: 739 PAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRD-LLLHDQCQITTLRLSNNPLTAAGVA 797
PA L+ L R LGL L P+A + L D L L+ + L LS L +AG
Sbjct: 451 PAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQ 510
Query: 798 VLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYN 845
V+ + + +V+ L L G G + + L+ A + R+R L+ + + N
Sbjct: 511 VIQDLVCDAGAVSSLDLADNGFGSDMVTLVLA-IGRSRSLRHVALGRN 557
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,581,329
Number of Sequences: 37866
Number of extensions: 1821084
Number of successful extensions: 5221
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 4791
Number of HSP's gapped (non-prelim): 276
length of query: 975
length of database: 18,247,518
effective HSP length: 112
effective length of query: 863
effective length of database: 14,006,526
effective search space: 12087631938
effective search space used: 12087631938
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.