Search of human proteins with 25282469

Search of human proteins with 25282469

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
         (341 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                   693   0.0  
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]          265   6e-71
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...   238   6e-63
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...   212   3e-55
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]        212   4e-55
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...   183   2e-46
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...   144   1e-34
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     84   2e-16
gi|40254992 carbonic reductase 4 [Homo sapiens]                        83   3e-16
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    76   4e-14
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    75   1e-13
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    73   4e-13
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    72   7e-13
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     68   1e-11
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           67   2e-11
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            67   3e-11
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]         67   3e-11
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    65   9e-11
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    60   4e-09
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo...    59   5e-09
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         59   6e-09
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    59   8e-09
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    58   1e-08
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    56   4e-08
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    56   4e-08
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    55   7e-08
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   55   9e-08
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          55   9e-08
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        55   1e-07
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...    54   2e-07

>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score =  693 bits (1789), Expect = 0.0
 Identities = 341/341 (100%), Positives = 341/341 (100%)

Query: 1   MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR 60
           MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR
Sbjct: 1   MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR 60

Query: 61  ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG 120
           ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG
Sbjct: 61  ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG 120

Query: 121 KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF 180
           KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF
Sbjct: 121 KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF 180

Query: 181 LPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTL 240
           LPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTL
Sbjct: 181 LPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTL 240

Query: 241 VCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMK 300
           VCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMK
Sbjct: 241 VCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMK 300

Query: 301 SILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI 341
           SILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI
Sbjct: 301 SILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI 341


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score =  265 bits (676), Expect = 6e-71
 Identities = 141/325 (43%), Positives = 201/325 (61%), Gaps = 26/325 (8%)

Query: 6   EFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVL 65
           + F+   K L++ + A    L+    K+VAG++ LITGAGSGLGRL AL+FAR  ++LVL
Sbjct: 10  KLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVL 69

Query: 66  WDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENV 125
           WDIN + NEET  M R              +AG            +V  YTCD  ++E V
Sbjct: 70  WDINKEGNEETCKMAR--------------EAGA----------TRVHAYTCDCSQKEGV 105

Query: 126 YLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTML 185
           Y  A++V+KEVG+VS+L+NNAG+V+G   L+CPDEL+E++  VN  AH WT KAFLP M+
Sbjct: 106 YRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMI 165

Query: 186 EINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYL 245
             +HGH+V ++SS GL    G+ DYCASKF   GF ES+  E    ++ GIKTT+VCP+ 
Sbjct: 166 ANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFF 225

Query: 246 VDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPF 305
           + TGMF GC         LP L+P Y V++ ++AIL ++  +  P+L+Y + F+KS LP 
Sbjct: 226 IKTGMFEGC--TTGCPSLLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPL 283

Query: 306 EAVVCMYRFLGADKCMYPFIAQRKQ 330
           +  + +  +LG    M  F+ Q+K+
Sbjct: 284 KTGLLIADYLGILHAMDGFVDQKKK 308


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score =  238 bits (607), Expect = 6e-63
 Identities = 128/337 (37%), Positives = 195/337 (57%), Gaps = 35/337 (10%)

Query: 1   MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR 60
           M+++ +  V+  K  + F+ +    ++  K+K+VAG++ L TGAGSGLGR  A+ FAR  
Sbjct: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60

Query: 61  ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG 120
           A+LVLWD+N + N ET  + +              + G            +VF YTCD  
Sbjct: 61  AILVLWDVNQEGNMETCRLAKE-------------KGGK-----------KVFPYTCDCS 96

Query: 121 KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF 180
            R+ VY  A++VRKE G+V++LVNNA +V+G   L+ PD ++E++ +VN   HFWT KAF
Sbjct: 97  NRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAF 156

Query: 181 LPTMLEINHGHIVTVASSLGLFSTAGVED-------YCASKFGVVGFHESLSHELKAAEK 233
           LP +++ NHGH+V ++S  G+    G+ D       Y ASKF   GF ESL  EL   +K
Sbjct: 157 LPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKK 216

Query: 234 DGIKTTLVCPYLVDTGMFRGCRIRKEIEPF-LPPLKPDYCVKQAMKAILTDQPMICTPRL 292
             +K+T+VCP+ ++TGMF GC  +    PF LP L+ +Y  K+ + AIL +Q  +  P+ 
Sbjct: 217 TEVKSTIVCPHFINTGMFEGCTSK---YPFLLPILEQEYVAKKILNAILEEQVYLMIPKF 273

Query: 293 MYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRK 329
            YI   +K I+  + ++    +LG D CM  F  ++K
Sbjct: 274 AYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGRKK 310


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score =  212 bits (540), Expect = 3e-55
 Identities = 119/313 (38%), Positives = 172/313 (54%), Gaps = 30/313 (9%)

Query: 1   MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR 60
           MNI++E  ++   ++++++ +  ++ +  + KSVAG++ LITGAG G+GR    EFA+R+
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60

Query: 61  ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG 120
           ++LVLWDIN +  EETA   R +                          +    Y  D  
Sbjct: 61  SILVLWDINKRGVEETAAECRKL-------------------------GVTAHAYVVDCS 95

Query: 121 KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF 180
            RE +Y +  +V+KEVG+V+++VNNAG V    LL   DE I +T  VN   HFW TKA 
Sbjct: 96  NREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKAL 155

Query: 181 LPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTL 240
           LP+M+E NHGHIVTVAS  G      +  YC+SKF  VGFH  L+ EL+A  K GIKT+ 
Sbjct: 156 LPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSC 215

Query: 241 VCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMK 300
           +CP  V+TG  +    R       P L+ D  V+  +  ILT++ MI  P  + I   ++
Sbjct: 216 LCPVFVNTGFTKNPSTR-----LWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQ 270

Query: 301 SILPFEAVVCMYR 313
             LP  A   + R
Sbjct: 271 KFLPERASAILNR 283


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score =  212 bits (539), Expect = 4e-55
 Identities = 119/275 (43%), Positives = 160/275 (58%), Gaps = 30/275 (10%)

Query: 30  KEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEA 89
           + KSV G++ LITGAG G+GRL A EFA+ ++ LVLWDIN    EETA   + +      
Sbjct: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGL------ 83

Query: 90  ADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVV 149
                                +V T+  D   RE++Y +A++V+ E+G+VS+LVNNAGVV
Sbjct: 84  -------------------GAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVV 124

Query: 150 SGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVED 209
               L    D  IE+T  VN  AHFWTTKAFLP M + NHGHIVTVAS+ G  S   +  
Sbjct: 125 YTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLA 184

Query: 210 YCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKP 269
           YC+SKF  VGFH++L+ EL A +  G+KTT +CP  V+TG      I+       P L+P
Sbjct: 185 YCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGF-----IKNPSTSLGPTLEP 239

Query: 270 DYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILP 304
           +  V + M  ILT+Q MI  P  +  +T ++ ILP
Sbjct: 240 EEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILP 274


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score =  183 bits (464), Expect = 2e-46
 Identities = 109/313 (34%), Positives = 167/313 (53%), Gaps = 30/313 (9%)

Query: 13  KVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRAL-LVLWDINTQ 71
           ++++  V AA   ++  K + ++ +  LITG G G+GR  A EFA R A  +VLW    +
Sbjct: 15  QMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEK 74

Query: 72  SNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAER 131
             +ET   +R +                           +   + CDVG RE VY TA+ 
Sbjct: 75  CLKETTEEIRQM-------------------------GTECHYFICDVGNREEVYQTAKA 109

Query: 132 VRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGH 191
           VR++VG++++LVNNA VV G  L++  D+ + ++  +N    FWTTKAFLP MLE+ +GH
Sbjct: 110 VREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGH 169

Query: 192 IVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMF 251
           IV + S L L +  G  DYC SK     F ESL+  L   +  G+  T V P+   T MF
Sbjct: 170 IVCLNSVLALSAIPGAIDYCTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMF 227

Query: 252 RGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCM 311
           +G R+R       PPLKP+   ++ ++A+  +Q ++  P  M+ +  +KSILP  A+  +
Sbjct: 228 QGMRVR--FPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEI 285

Query: 312 YRFLGADKCMYPF 324
           ++F G   CM  F
Sbjct: 286 HKFSGTYTCMNTF 298


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score =  144 bits (363), Expect = 1e-34
 Identities = 83/200 (41%), Positives = 115/200 (57%), Gaps = 7/200 (3%)

Query: 116 TCDVGKRENVYLTAE--RVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAH 173
           T +  KR+++ +  +  +V+KEVG+V+++VNNAG V    LL   DE I +T  VN   H
Sbjct: 53  TYEFAKRQSILVLWDINKVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGH 112

Query: 174 FWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEK 233
           FW TKA LP+M+E NHGHIVTVAS  G      +  YC+SKF  VGFH  L+ EL+A  K
Sbjct: 113 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 172

Query: 234 DGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLM 293
            GIKT+ +CP  V+TG  +    R       P L+ D  V+  +  ILT++ MI  P  +
Sbjct: 173 TGIKTSCLCPVFVNTGFTKNPSTR-----LWPVLETDEVVRSLIDGILTNKKMIFVPSYI 227

Query: 294 YIVTFMKSILPFEAVVCMYR 313
            I   ++  LP  A   + R
Sbjct: 228 NIFLRLQKFLPERASAILNR 247


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 70/238 (29%), Positives = 107/238 (44%), Gaps = 31/238 (13%)

Query: 36  GQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAAL 95
           G+V L+TGAG+GLGR +AL FA R AL+V+ D+                 D +     +L
Sbjct: 9   GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGG---------------DFKGVGKGSL 53

Query: 96  QAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLL 155
            A    EEI       V  Y   V + E V  TA       G + V+VNNAG++      
Sbjct: 54  AADKVVEEIRRRGGKAVANYD-SVEEGEKVVKTA---LDAFGRIDVVVNNAGILRDRSFA 109

Query: 156 ECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKF 215
              DE  +    V+    F  T+A    M +  +G I+  +S+ G++   G  +Y A+K 
Sbjct: 110 RISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKL 169

Query: 216 GVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEP--FLPPLKPDY 271
           G++G   SL+ E       G K+ + C  +       G R+ + + P   +  LKP+Y
Sbjct: 170 GLLGLANSLAIE-------GRKSNIHCNTIAPNA---GSRMTQTVMPEDLVEALKPEY 217


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 66/214 (30%), Positives = 94/214 (43%), Gaps = 31/214 (14%)

Query: 37  QVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQ 96
           +VC + G   G+GR  A   AR+   L +                 I R+LE A AAA  
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAV-----------------IARNLEGAKAAAGD 45

Query: 97  AGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLE 156
            G                ++CDV K  +V  T E + K +G V+ LVN AG+     L+ 
Sbjct: 46  LGGDH-----------LAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVR 94

Query: 157 CPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFG 216
              E +   +  N      T KA + TM++   G IV V S +GL   +G   Y ASK G
Sbjct: 95  TKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGG 154

Query: 217 VVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250
           +VGF  +L+ E+    +  I+  +V P  V T M
Sbjct: 155 LVGFSRALAKEV---ARKKIRVNVVAPGFVHTDM 185


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 65/221 (29%), Positives = 96/221 (43%), Gaps = 23/221 (10%)

Query: 23  ARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRH 82
           A W  R  E  +   V  +TGA SG+G   A + ++    LVL               R 
Sbjct: 37  AEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVL-------------SARR 83

Query: 83  IYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVL 142
           ++ +LE      L+ GN +E+ +    L +     D G  E      + V +E G + +L
Sbjct: 84  VH-ELERVKRRCLENGNLKEKDILVLPLDL----TDTGSHE---AATKAVLQEFGRIDIL 135

Query: 143 VNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLF 202
           VNN G+      ++   ++  + + +N       TK  LP M+E   G IVTV S LG+ 
Sbjct: 136 VNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGII 195

Query: 203 STAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCP 243
           S      YCASK  + GF   L  EL  A   GI  + +CP
Sbjct: 196 SVPLSIGYCASKHALRGFFNGLRTEL--ATYPGIIVSNICP 234


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 61/213 (28%), Positives = 95/213 (44%), Gaps = 22/213 (10%)

Query: 38  VCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQA 97
           V +ITGA SGLG+  A  F    A LVL   N        G +  + R+L A+ A  +Q 
Sbjct: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRN-------GGALEELIRELTASHATKVQT 106

Query: 98  GNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLEC 157
                        + +  T D+     +   A  + +  G V +LVNNAG+     +++ 
Sbjct: 107 H------------KPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDT 154

Query: 158 PDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGV 217
             ++ +R M  N       TKA LP+M++   GHIV ++S  G  S      Y ASK   
Sbjct: 155 TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHAT 214

Query: 218 VGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250
             F + L  E++  E   I+ T++ P  + T +
Sbjct: 215 QAFFDCLRAEMEQYE---IEVTVISPGYIHTNL 244


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 70/273 (25%), Positives = 117/273 (42%), Gaps = 30/273 (10%)

Query: 12  FKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQ 71
           F V +  +L     L+ PK  ++ G   ++TG  SG+G+  A+E  ++ A + L      
Sbjct: 8   FLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITL------ 61

Query: 72  SNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKREN-VYLTAE 130
                  + R+  + L+A     + + N ++ +L          + DV +  N V    +
Sbjct: 62  -------VARNEDKLLQAKKEIEMHSINDKQVVL--------CISVDVSQDYNQVENVIK 106

Query: 131 RVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHG 190
           + ++++G V +LVN AG+       +      ER M +N     + ++A + TM E   G
Sbjct: 107 QAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVG 166

Query: 191 HIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250
            IV V+S  G     G   Y ASKF + G  E+L  E+K      +  T+  P   DT  
Sbjct: 167 RIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPY---NVYITVAYPPDTDTPG 223

Query: 251 FRGCRIRKEIEPFL-----PPLKPDYCVKQAMK 278
           F      K +E  L        KP+   KQ +K
Sbjct: 224 FAEENRTKPLETRLISETTSVCKPEQVAKQIVK 256


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 66/229 (28%), Positives = 101/229 (44%), Gaps = 37/229 (16%)

Query: 34  VAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAA 93
           V G+V L+TGA  G+GR FA     + A + L D N ++  +                 A
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCK---------------A 47

Query: 94  ALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHH 153
           AL     +E+  P   L +    CDV  ++ +  T  +V    G + +LVNNAGV +   
Sbjct: 48  AL-----DEQFEPQKTLFI---QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNN--- 96

Query: 154 LLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGH---IVTVASSLGLFSTAGVEDY 210
                ++  E+T+ +N  +    T   L  M + N G    I+ ++S  GL   A    Y
Sbjct: 97  -----EKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVY 151

Query: 211 CASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKE 259
           CASK G+VGF  S +         G++   +CP  V+T +     I KE
Sbjct: 152 CASKHGIVGFTRSAALAANLM-NSGVRLNAICPGFVNTAILES--IEKE 197


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 42/216 (19%)

Query: 36  GQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAAL 95
           G+V ++T A  G+G+  AL FAR  A ++  DIN    +E                    
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQEL------------------- 46

Query: 96  QAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLL 155
                  E  P    +V     DV K++ +    ++   EV  + VL N AG V    +L
Sbjct: 47  -------EKYPGIQTRVL----DVTKKKQI----DQFANEVERLDVLFNVAGFVHHGTVL 91

Query: 156 ECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYC---A 212
           +C ++  + +M +N  + +   KAFLP ML    G+I+ ++S     S  GV + C    
Sbjct: 92  DCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVAS--SVKGVVNRCVYST 149

Query: 213 SKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDT 248
           +K  V+G  +S++ +     + GI+   VCP  VDT
Sbjct: 150 TKAAVIGLTKSVAADF---IQQGIRCNCVCPGTVDT 182


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 56/215 (26%), Positives = 95/215 (44%), Gaps = 23/215 (10%)

Query: 38  VCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQA 97
           + L+TGAGSG+GR  ++  A   A +   D++  + +ET  ++                 
Sbjct: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLL----------------G 56

Query: 98  GNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEV-SVLVNNAGVVSGHHLLE 156
           G G +E  P  N   F    DV +        E+V+       SV+V+ AG+     LL 
Sbjct: 57  GPGSKEGPPRGNHAAFQ--ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLH 114

Query: 157 CPDELIERTMMVNCHAHFWTTKAFLPTMLEIN-HGHIVTVASSLGLFSTAGVEDYCASKF 215
             ++  ++ + VN    F  T+A    ++     G I+ ++S +G     G  +Y ASK 
Sbjct: 115 MSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKA 174

Query: 216 GVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250
           GV+G  ++ + EL    + GI+   V P  + T M
Sbjct: 175 GVIGLTQTAAREL---GRHGIRCNSVLPGFIATPM 206


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 74/266 (27%), Positives = 117/266 (43%), Gaps = 50/266 (18%)

Query: 2   NIVVEFFVVTFKVLWAFVLAAA----------RWLVRPKE--KSVAGQVCLITGAGSGLG 49
           +++ +FF++T  ++    LA             W V PK   +S+ GQ  +ITGAG G+G
Sbjct: 3   DVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSM-GQWAVITGAGDGIG 61

Query: 50  RLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCN 109
           + ++ E A+R   +VL                 I R LE  +A A        EI     
Sbjct: 62  KAYSFELAKRGLNVVL-----------------ISRTLEKLEAIA-------TEIERTTG 97

Query: 110 LQVFTYTCDVGKRENVYLTAERVRKEVG--EVSVLVNNAGVVSG---HHLLECPDELIER 164
             V     D  K +++Y   E +++++   E+ +LVNN G++      H L  PDE I+ 
Sbjct: 98  RSVKIIQADFTK-DDIY---EHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDE-IQS 152

Query: 165 TMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESL 224
            +  N  +    T+  L  M     G I+ ++S + LF       Y ASK  V  F ++L
Sbjct: 153 LIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKAL 212

Query: 225 SHELKAAEKDGIKTTLVCPYLVDTGM 250
             E KA E   +   ++ PY V T M
Sbjct: 213 QEEYKAKE---VIIQVLTPYAVSTAM 235


>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
          Length = 418

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 49/204 (24%), Positives = 90/204 (44%), Gaps = 22/204 (10%)

Query: 29  PKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLE 88
           P    +AG    ITGA  G+G+  AL+ A+  A +V+     Q + +  G +     ++E
Sbjct: 3   PNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIE 62

Query: 89  AADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGV 148
           A    AL                      DV   + +    E+  K+ G + +LVNNA  
Sbjct: 63  AVGGKALPC------------------IVDVRDEQQISAAVEKAIKKFGGIDILVNNASA 104

Query: 149 VSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVE 208
           +S  + L+ P + ++  M VN    +  +KA +P + +    HI+ ++  L L +    +
Sbjct: 105 ISLTNTLDTPTKRLDLMMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNL-NPVWFK 163

Query: 209 DYCA---SKFGVVGFHESLSHELK 229
            +CA   +K+G+  +   ++ E K
Sbjct: 164 QHCAYTIAKYGMSMYVLGMAEEFK 187


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 58/193 (30%), Positives = 87/193 (45%), Gaps = 34/193 (17%)

Query: 34  VAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAA 93
           V G+V L+TGA  G+GR FA     + A + L D N ++  +                 A
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCK---------------A 47

Query: 94  ALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHH 153
           AL     +E+  P   L +    CDV  ++ +  T  +V    G + +LVNNAGV +   
Sbjct: 48  AL-----DEQFEPQKTLFI---QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNN--- 96

Query: 154 LLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGH---IVTVASSLGLFSTAGVEDY 210
                ++  E+T+ +N  +    T   L  M + N G    I+ ++S  GL   A    Y
Sbjct: 97  -----EKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVY 151

Query: 211 CASKFGVVGFHES 223
           CASK G+VGF  S
Sbjct: 152 CASKHGIVGFTRS 164


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 44/244 (18%)

Query: 14  VLWAFVLAAARWLVRPKEKSVAGQVCL-ITGAGSGLGRLFALEFARRRALLVLWDINTQS 72
           +L   +L A  WL+R ++   A    + ITG  SG GRL AL+  +R   ++        
Sbjct: 5   LLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVL-------- 56

Query: 73  NEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERV 132
                               A+    +G E++    + ++ T   D+   ++V   A+ V
Sbjct: 57  --------------------ASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWV 96

Query: 133 RKEVGEVSV--LVNNAGV--VSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEIN 188
              V E  +  LVNNAGV  + G       D+  +R + VN       T A LP +L+  
Sbjct: 97  EMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD-FQRVLNVNTMGPIGVTLALLP-LLQQA 154

Query: 189 HGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDT 248
            G ++ + S LG  +  G   YC SKFG+  F +SL  ++      GI+ ++V P     
Sbjct: 155 RGRVINITSVLGRLAANG-GGYCVSKFGLEAFSDSLRRDV---AHFGIRVSIVEP----- 205

Query: 249 GMFR 252
           G FR
Sbjct: 206 GFFR 209


>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
           sapiens]
          Length = 336

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 62/243 (25%), Positives = 97/243 (39%), Gaps = 35/243 (14%)

Query: 36  GQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAAL 95
           G+  LITGA SGLGR  A E  R  A +++   +    EE AG +R   R  +AA+    
Sbjct: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELR--QAAECGPE 100

Query: 96  QAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLL 155
              +G  E++            D+    +V    + + +E   + VL+NNAG+       
Sbjct: 101 PGVSGVGELI--------VRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGI------F 146

Query: 156 ECP----DELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVED-- 209
           +CP    ++  E    VN   HF  T   L  +       IV V+S L  +     +D  
Sbjct: 147 QCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLN 206

Query: 210 ----------YCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKE 259
                     Y  SK   + F   L+  L   E   +   ++ P +V T + R   I   
Sbjct: 207 SEQSYNKSFCYSRSKLANILFTRELARRL---EGTNVTVNVLHPGIVRTNLGRHIHIPLL 263

Query: 260 IEP 262
           ++P
Sbjct: 264 VKP 266


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 57/237 (24%), Positives = 98/237 (41%), Gaps = 41/237 (17%)

Query: 29  PKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLE 88
           P + ++ G+  ++TGA +G+G+  ALE ARR   ++L                   RD+E
Sbjct: 31  PSKATIPGKTVIVTGANTGIGKQTALELARRGGNIIL-----------------ACRDME 73

Query: 89  AADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGV 148
             +AAA       E +  H N +      D+   +++   A ++ +E   V +L+NNAGV
Sbjct: 74  KCEAAAKDIRG--ETLNHHVNAR----HLDLASLKSIREFAAKIIEEEERVDILINNAGV 127

Query: 149 VSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVE 208
           +   H     ++  E    VN   HF  T   L  +       I+ ++S   +      +
Sbjct: 128 MRCPHW--TTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFD 185

Query: 209 D-------------YCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFR 252
           D             YC SK  +V F + LS  L+ +   G+    + P +  T + R
Sbjct: 186 DLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGS---GVTVNALHPGVARTELGR 239


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 69/295 (23%), Positives = 119/295 (40%), Gaps = 40/295 (13%)

Query: 16  WAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEE 75
           W  V  A+  + R     +A +V L+T +  G+G   A   A+  A +V+     Q+ ++
Sbjct: 14  WNSVRMASSGMTR--RDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQ 71

Query: 76  TAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKE 135
                           A A   G G         L V    C VGK E+         K 
Sbjct: 72  ----------------AVATLQGEG---------LSVTGTVCHVGKAEDRERLVATAVKL 106

Query: 136 VGEVSVLVNNAGVVSGH-HLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVT 194
            G + +LV+NA V      +++  +E+ ++T+ +N  A    TKA +P M +   G +V 
Sbjct: 107 HGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVI 166

Query: 195 VASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGC 254
           V+S      + G   Y  SK  ++G  ++L+ EL       I+   + P L+ T   R  
Sbjct: 167 VSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPR---NIRVNCLAPGLIKTSFSRML 223

Query: 255 RIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVV 309
            + KE E           +K+ ++     +P  C   + ++ +   S +  E VV
Sbjct: 224 WMDKEKEE---------SMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVV 269


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 51/161 (31%), Positives = 80/161 (49%), Gaps = 8/161 (4%)

Query: 93  AALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSV--LVNNAGVVS 150
           AA     G E++    + ++ T T DV K E++    + V++ VG+  +  LVNNAG+++
Sbjct: 58  AACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILT 117

Query: 151 GHHLLECPDELIERTMM-VNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVED 209
              L E  +      M+ VN       T + LP ++    G IV V+S LG  +   V  
Sbjct: 118 PITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAFF-VGG 175

Query: 210 YCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250
           YC SK+GV  F + L  E+   +  G+K ++V P    TGM
Sbjct: 176 YCVSKYGVEAFSDILRREI---QHFGVKISIVEPGYFRTGM 213


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 58/197 (29%), Positives = 79/197 (40%), Gaps = 31/197 (15%)

Query: 34  VAGQVCLITGAGSGLGRLFALEFARR-----RALLVLWDINTQSNEETAGMVRHIYRDLE 88
           +A  V LITG  SG+G   A+  A       +    L D+ TQ             R  E
Sbjct: 1   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQG------------RLWE 48

Query: 89  AADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGV 148
           AA A A   G+ E              T  +  R++  + A R R   G V VLV NAG+
Sbjct: 49  AARALACPPGSLE--------------TLQLDVRDSKSVAAARERVTEGRVDVLVCNAGL 94

Query: 149 VSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVE 208
                L    ++ +   + VN        +AFLP M     G ++   S  GL      +
Sbjct: 95  GLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFND 154

Query: 209 DYCASKFGVVGFHESLS 225
            YCASKF + G  ESL+
Sbjct: 155 VYCASKFALEGLCESLA 171


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 15/171 (8%)

Query: 93  AALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSV--LVNNAGV-- 148
           AA     G +++    + ++ T   DV K E++   A+ VR +VGE  +  LVNNAGV  
Sbjct: 54  AACFTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGL 113

Query: 149 VSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVE 208
            SG +     D+ + + + VN       T   LP M++   G +V ++SS G  +  G  
Sbjct: 114 PSGPNEWLTKDDFV-KVINVNLVGLIEVTLHMLP-MVKRARGRVVNMSSSGGRVAVIG-G 170

Query: 209 DYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKE 259
            YC SKFGV  F +S+  EL      G+K   VC  +++ G +R   + KE
Sbjct: 171 GYCVSKFGVEAFSDSIRRELYYF---GVK---VC--IIEPGNYRTAILGKE 213


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 51/196 (26%), Positives = 84/196 (42%), Gaps = 26/196 (13%)

Query: 34  VAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAA 93
           +  +V L+T +  G+G   A   A+ RA +V+     Q+ ++                A 
Sbjct: 30  LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQ----------------AV 73

Query: 94  ALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGH- 152
           A   G G         L V    C VGK E+         K  G + +LV+NA V     
Sbjct: 74  ATLQGEG---------LSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFG 124

Query: 153 HLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCA 212
            L++  +E+ ++T+ +N  A    TKA +P M +   G +V V+S      + G   Y  
Sbjct: 125 SLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNV 184

Query: 213 SKFGVVGFHESLSHEL 228
           SK  ++G + +L+ EL
Sbjct: 185 SKTALLGLNNTLAIEL 200


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 54/177 (30%), Positives = 85/177 (48%), Gaps = 19/177 (10%)

Query: 77  AGMVRHIYRDLEAADAAALQA---GNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVR 133
           +G  + + R L+A     L A     G E++    + ++ T T DV K E+V   A+ V+
Sbjct: 39  SGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVK 98

Query: 134 KEVGEVSV--LVNNAGVVSGHHLLECPDELIERT-----MMVNCHAHFWTTKAFLPTMLE 186
           + V +  +  LVNNAG+     L   P+EL+ +      + VN       T + LP ++ 
Sbjct: 99  ECVRDKGLWGLVNNAGI----SLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLP-LVR 153

Query: 187 INHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCP 243
              G +V V+S +G  S  G   YC SK+GV  F +SL  EL      G+K  ++ P
Sbjct: 154 RARGRVVNVSSVMGRVSLFG-GGYCISKYGVEAFSDSLRRELSYF---GVKVAMIEP 206


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 56/196 (28%), Positives = 79/196 (40%), Gaps = 24/196 (12%)

Query: 33  SVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADA 92
           + A +  LI+G  SG+G   A++ A               + +    V    RDL   + 
Sbjct: 2   AAAPRTVLISGCSSGIGLELAVQLAH--------------DPKKRYQVVATMRDLGKKET 47

Query: 93  AALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGH 152
               AG    + L    L       DV   E+V      ++   GEV VLVNNAG+    
Sbjct: 48  LEAAAGEALGQTLTVAQL-------DVCSDESVAQCLSCIQ---GEVDVLVNNAGMGLVG 97

Query: 153 HLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCA 212
            L       ++     N        KA LP M     GHIV ++S +GL      + Y A
Sbjct: 98  PLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAA 157

Query: 213 SKFGVVGFHESLSHEL 228
           SKF + GF ESL+ +L
Sbjct: 158 SKFALEGFFESLAIQL 173


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 56/227 (24%), Positives = 94/227 (41%), Gaps = 28/227 (12%)

Query: 26  LVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYR 85
           + RP  +    ++ L+TGA  G+G   A      RAL+       Q   +  G  R +  
Sbjct: 1   MARPGMERWRDRLALVTGASGGIGAAVA------RALV-------QQGLKVVGCARTVGN 47

Query: 86  DLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNN 145
             E A  A  ++      ++P        Y CD+   E++      +R +   V + +NN
Sbjct: 48  IEELA--AECKSAGYPGTLIP--------YRCDLSNEEDILSMFSAIRSQHSGVDICINN 97

Query: 146 AGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLE--INHGHIVTVASSLG--L 201
           AG+     LL       +    VN  A    T+    +M E  ++ GHI+ + S  G  +
Sbjct: 98  AGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRV 157

Query: 202 FSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDT 248
              +    Y A+K+ V    E L  EL+ A+   I+ T + P +V+T
Sbjct: 158 LPLSVTHFYSATKYAVTALTEGLRQELREAQTH-IRATCISPGVVET 203


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 67/267 (25%), Positives = 107/267 (40%), Gaps = 44/267 (16%)

Query: 12  FKVLWAFVLAAARWLVRPKEK--SVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDIN 69
           F VL   +L    W  + K K   +  +   ITG  SG G L A  F ++   ++     
Sbjct: 3   FWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVI----- 57

Query: 70  TQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTA 129
                                  AA    +G   +    + ++ T   DV   ENV  TA
Sbjct: 58  -----------------------AACLTESGSTALKAETSERLRTVLLDVTDPENVKRTA 94

Query: 130 ERVRKEVGEVSV--LVNNAGVVSGHHLLECPDELI----ERTMMVNCHAHFWTTKAFLPT 183
           + V+ +VGE  +  L+NNAGV     +L   D L        + VN       T   LP 
Sbjct: 95  QWVKNQVGEKGLWGLINNAGVPG---VLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP- 150

Query: 184 MLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCP 243
           +++   G ++ V+S  G  +  G   Y  SK+ V GF++SL  ++KA    G+  + + P
Sbjct: 151 LVKKAQGRVINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMKAF---GVHVSCIEP 206

Query: 244 YLVDTGMFRGCRIRKEIEPFLPPLKPD 270
            L  T +    ++ ++       L PD
Sbjct: 207 GLFKTNLADPVKVIEKKLAIWEQLSPD 233


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,907,140
Number of Sequences: 37866
Number of extensions: 487412
Number of successful extensions: 1312
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1199
Number of HSP's gapped (non-prelim): 90
length of query: 341
length of database: 18,247,518
effective HSP length: 103
effective length of query: 238
effective length of database: 14,347,320
effective search space: 3414662160
effective search space used: 3414662160
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.