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Search of human proteins with 24497458
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24497458 Shaw-related voltage-gated potassium channel
protein 2 isoform KV3.2c [Homo sapiens]
(558 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24497458 Shaw-related voltage-gated potassium channel protein... 1147 0.0
gi|21217561 Shaw-related voltage-gated potassium channel protein... 1108 0.0
gi|21217563 Shaw-related voltage-gated potassium channel protein... 1108 0.0
gi|163792201 Shaw-related voltage-gated potassium channel protei... 746 0.0
gi|4826786 Shaw-related voltage-gated potassium channel protein ... 743 0.0
gi|88758576 Shaw-related voltage-gated potassium channel protein... 742 0.0
gi|24497462 Shaw-related voltage-gated potassium channel protein... 742 0.0
gi|24497464 Shaw-related voltage-gated potassium channel protein... 739 0.0
gi|24497460 Shaw-related voltage-gated potassium channel protein... 689 0.0
gi|4826784 potassium voltage-gated channel, Shab-related subfami... 293 3e-79
gi|27436974 potassium voltage-gated channel, Shab-related subfam... 290 2e-78
gi|119395748 potassium voltage-gated channel subfamily A member ... 258 1e-68
gi|5031819 potassium voltage-gated channel, shaker-related subfa... 257 2e-68
gi|27436981 potassium voltage-gated channel, Shal-related subfam... 251 9e-67
gi|25952092 potassium voltage-gated channel, shaker-related subf... 251 9e-67
gi|20070166 potassium voltage-gated channel, subfamily F, member... 251 1e-66
gi|4504817 potassium voltage-gated channel, shaker-related subfa... 247 2e-65
gi|27436984 potassium voltage-gated channel, Shal-related subfam... 246 4e-65
gi|27436986 potassium voltage-gated channel, Shal-related subfam... 246 4e-65
gi|4826782 potassium voltage-gated channel, shaker-related subfa... 246 4e-65
gi|25952108 potassium voltage-gated channel delayed-rectifier pr... 246 5e-65
gi|88758565 potassium voltage-gated channel, shaker-related subf... 245 7e-65
gi|4504821 potassium voltage-gated channel, shaker-related subfa... 242 7e-64
gi|9789987 potassium voltage-gated channel, Shal-related subfami... 241 2e-63
gi|25952087 potassium voltage-gated channel, shaker-related subf... 238 1e-62
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens] 229 4e-60
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ... 229 4e-60
gi|13492973 potassium voltage-gated channel delayed-rectifier pr... 223 5e-58
gi|27436988 potassium voltage-gated channel, subfamily G, member... 217 2e-56
gi|6912444 potassium voltage-gated channel, subfamily G, member ... 210 3e-54
>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2c [Homo sapiens]
Length = 558
Score = 1147 bits (2967), Expect = 0.0
Identities = 558/558 (100%), Positives = 558/558 (100%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP
Sbjct: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT
Sbjct: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
Query: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL
Sbjct: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
Query: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR
Sbjct: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
Query: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK
Sbjct: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
Query: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ
Sbjct: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY
Sbjct: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
Query: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSDN 540
SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSDN
Sbjct: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSDN 540
Query: 541 CKEVVITGYTQAEARSLT 558
CKEVVITGYTQAEARSLT
Sbjct: 541 CKEVVITGYTQAEARSLT 558
>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2a [Homo sapiens]
Length = 613
Score = 1108 bits (2865), Expect = 0.0
Identities = 538/538 (100%), Positives = 538/538 (100%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP
Sbjct: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT
Sbjct: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
Query: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL
Sbjct: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
Query: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR
Sbjct: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
Query: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK
Sbjct: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
Query: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ
Sbjct: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY
Sbjct: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
Query: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS 538
SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS
Sbjct: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS 538
>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2b [Homo sapiens]
Length = 638
Score = 1108 bits (2865), Expect = 0.0
Identities = 538/538 (100%), Positives = 538/538 (100%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP
Sbjct: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT
Sbjct: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPG 180
Query: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL
Sbjct: 181 DDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFIL 240
Query: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR
Sbjct: 241 VSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVR 300
Query: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK
Sbjct: 301 IVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFK 360
Query: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ
Sbjct: 361 LTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ 420
Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY
Sbjct: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
Query: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS 538
SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS
Sbjct: 481 SLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRS 538
>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
isoform A [Homo sapiens]
Length = 585
Score = 746 bits (1925), Expect = 0.0
Identities = 390/555 (70%), Positives = 426/555 (76%), Gaps = 67/555 (12%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
MG+ + +ER+++NVGGTRH+TYRSTL+TLPGTRLA LA +
Sbjct: 1 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSH--------------- 45
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
PRA EFFFDRHPGVFA++LNYYRT
Sbjct: 46 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT 73
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 171
GKLHCPADVCGPL+EEELAFWGIDETDVEPCCWMTYRQHRDAEEALD F +
Sbjct: 74 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133
Query: 172 PDLIG-GDPGDDEDLA--AKRLGIEDAAGLGGPDGKSGR-WRRLQPRMWALFEDPYSSRA 227
D G GD GD ED KRL + D+ PDG+ G WRR QPR+WALFEDPYSSR
Sbjct: 134 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY 188
Query: 228 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 285
AR++AFASLFFILVSITTFCLETHE FN + NKTE V NGT V E ET+ LTY+
Sbjct: 189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI 248
Query: 286 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 345
EGVCVVWFTFEFL+R++F PNK+EFIKN LNIIDFVAILPFYLEVGLSGLSSKAAKDVLG
Sbjct: 249 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 308
Query: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405
FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER
Sbjct: 309 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 368
Query: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465
+GAQPNDPSASEHT FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI
Sbjct: 369 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428
Query: 466 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 525
AMPVPVIVNNFGMYYSLAMAKQKLP+K+KKHIP PQ SP +CK+ +N +STQSDTC
Sbjct: 429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC 488
Query: 526 LGKDNRLLEHNRSDN 540
+LE NR+D+
Sbjct: 489 PLAQEEILEINRADS 503
>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
isoform B [Homo sapiens]
Length = 511
Score = 743 bits (1918), Expect = 0.0
Identities = 389/553 (70%), Positives = 424/553 (76%), Gaps = 67/553 (12%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
MG+ + +ER+++NVGGTRH+TYRSTL+TLPGTRLA LA +
Sbjct: 1 MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSH--------------- 45
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
PRA EFFFDRHPGVFA++LNYYRT
Sbjct: 46 FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT 73
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 171
GKLHCPADVCGPL+EEELAFWGIDETDVEPCCWMTYRQHRDAEEALD F +
Sbjct: 74 GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133
Query: 172 PDLIG-GDPGDDEDLA--AKRLGIEDAAGLGGPDGKSGR-WRRLQPRMWALFEDPYSSRA 227
D G GD GD ED KRL + D+ PDG+ G WRR QPR+WALFEDPYSSR
Sbjct: 134 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY 188
Query: 228 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 285
AR++AFASLFFILVSITTFCLETHE FN + NKTE V NGT V E ET+ LTY+
Sbjct: 189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI 248
Query: 286 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 345
EGVCVVWFTFEFL+R++F PNK+EFIKN LNIIDFVAILPFYLEVGLSGLSSKAAKDVLG
Sbjct: 249 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 308
Query: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405
FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER
Sbjct: 309 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 368
Query: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465
+GAQPNDPSASEHT FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI
Sbjct: 369 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428
Query: 466 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 525
AMPVPVIVNNFGMYYSLAMAKQKLP+K+KKHIP PQ SP +CK+ +N +STQSDTC
Sbjct: 429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC 488
Query: 526 LGKDNRLLEHNRS 538
+LE NR+
Sbjct: 489 PLAQEEILEINRA 501
>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
isoform c [Homo sapiens]
Length = 626
Score = 742 bits (1915), Expect = 0.0
Identities = 391/550 (71%), Positives = 432/550 (78%), Gaps = 48/550 (8%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA + G
Sbjct: 29 MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
P + G GG G+ S GG GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 74 --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177
GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD G
Sbjct: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172
Query: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233
+ GDDE +LA +RLG + G G SG R QPRMWALFEDPYSSRAAR +AF
Sbjct: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230
Query: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291
ASLFFILVSITTFCLETHEAFNI +N TE V N TSV + E+ET+P LTY+EGVCV+
Sbjct: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290
Query: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351
WFT EFLVRIV P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350
Query: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411
FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410
Query: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471
DP ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470
Query: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530
IVNNFGMYYSLAMAKQKLP+KRKKH+P Q SP +CK+E +ST SDT ++
Sbjct: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530
Query: 531 RLLEHNRSDN 540
++E R+D+
Sbjct: 531 GMIERKRADS 540
>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
isoform a [Homo sapiens]
Length = 635
Score = 742 bits (1915), Expect = 0.0
Identities = 391/550 (71%), Positives = 432/550 (78%), Gaps = 48/550 (8%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA + G
Sbjct: 29 MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
P + G GG G+ S GG GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 74 --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177
GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD G
Sbjct: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172
Query: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233
+ GDDE +LA +RLG + G G SG R QPRMWALFEDPYSSRAAR +AF
Sbjct: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230
Query: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291
ASLFFILVSITTFCLETHEAFNI +N TE V N TSV + E+ET+P LTY+EGVCV+
Sbjct: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290
Query: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351
WFT EFLVRIV P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350
Query: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411
FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410
Query: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471
DP ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470
Query: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530
IVNNFGMYYSLAMAKQKLP+KRKKH+P Q SP +CK+E +ST SDT ++
Sbjct: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530
Query: 531 RLLEHNRSDN 540
++E R+D+
Sbjct: 531 GMIERKRADS 540
>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
isoform b [Homo sapiens]
Length = 582
Score = 739 bits (1908), Expect = 0.0
Identities = 390/548 (71%), Positives = 430/548 (78%), Gaps = 48/548 (8%)
Query: 1 MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60
M K E +E++I+NVGGTRHETYRSTL+TLPGTRLA LA + G
Sbjct: 29 MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR--------------- 73
Query: 61 LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120
P + G GG G+ S GG GG EFFFDRHPGVFAYVLNYYRT
Sbjct: 74 --------PETDG------GGVGSSGSSGG-------GGCEFFFDRHPGVFAYVLNYYRT 112
Query: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG--- 177
GKLHCPADVCGPLFEEEL FWGIDETDVEPCCWMTYRQHRDAEEALDIFE+PD G
Sbjct: 113 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAG 172
Query: 178 ---DPGDDE-DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAF 233
+ GDDE +LA +RLG + G G SG R QPRMWALFEDPYSSRAAR +AF
Sbjct: 173 PSDEAGDDERELALQRLGPHE--GGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAF 230
Query: 234 ASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYVEGVCVV 291
ASLFFILVSITTFCLETHEAFNI +N TE V N TSV + E+ET+P LTY+EGVCV+
Sbjct: 231 ASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVL 290
Query: 292 WFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVR 351
WFT EFLVRIV P+ L+F+KNLLNIIDFVAILPFYLEVGLSGLSSKAA+DVLGFLRVVR
Sbjct: 291 WFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVR 350
Query: 352 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPN 411
FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER+GA+P+
Sbjct: 351 FVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPS 410
Query: 412 DPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPV 471
DP ++HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPV
Sbjct: 411 DPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPV 470
Query: 472 IVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC-LGKDN 530
IVNNFGMYYSLAMAKQKLP+KRKKH+P Q SP +CK+E +ST SDT ++
Sbjct: 471 IVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREE 530
Query: 531 RLLEHNRS 538
++E R+
Sbjct: 531 GMIERKRA 538
>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
[Homo sapiens]
Length = 757
Score = 689 bits (1778), Expect = 0.0
Identities = 364/541 (67%), Positives = 394/541 (72%), Gaps = 88/541 (16%)
Query: 9 RVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAP 68
++++NVGG RHETYRSTL+TLPGTRLA L E
Sbjct: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPE--------------------------- 121
Query: 69 PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPAD 128
D+ G EFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 122 --------------------AAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPAD 161
Query: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG----------D 178
VCGPLFEEEL FWGIDETDVE CCWMTYRQHRDAEEALD FE PD G D
Sbjct: 162 VCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHD 221
Query: 179 PGDDEDLAA------------KRLGIEDAAG-LGGPDGKSGR-----WRRLQPRMWALFE 220
G D++ A KRL +DA G GGP G +G WRR QPR+WALFE
Sbjct: 222 GGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFE 281
Query: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKT---------EPVINGTSVV 271
DPYSSRAAR++AFASLFFIL+SITTFCLETHE F + NKT P N T+V
Sbjct: 282 DPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV- 340
Query: 272 LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVG 331
E+ET+P LTYVEGVCVVWFTFEFL+RI F P+K+EF+K+ LNIID VAILPFYLEVG
Sbjct: 341 ---EVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVG 397
Query: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL
Sbjct: 398 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 457
Query: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451
GVLIFATMIYYAER+GA P+D S HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGM
Sbjct: 458 GVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM 517
Query: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKT 511
LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLP+K+ KHIP PQ SP +CK
Sbjct: 518 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKP 577
Query: 512 E 512
+
Sbjct: 578 D 578
>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
member 1 [Homo sapiens]
Length = 858
Score = 293 bits (750), Expect = 3e-79
Identities = 181/492 (36%), Positives = 251/492 (51%), Gaps = 91/492 (18%)
Query: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66
+ RV LNVGG HE TL LP TRL L DC T D L
Sbjct: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLR------DCNTH--DSLLEV--------- 72
Query: 67 APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126
D+ E+FFDRHPG F +LN+YRTG+LH
Sbjct: 73 -------------------------CDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMM 107
Query: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184
++C F +EL +WGIDE +E CC Y Q ++ EE ET G+ D+
Sbjct: 108 EEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTC 167
Query: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244
A KR ++W L E P SS AA+ +A S+ FI++S
Sbjct: 168 CAEKR-----------------------KKLWDLLEKPNSSVAAKILAIISIMFIVLSTI 204
Query: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304
L T + + N P L +VE VC+ WFT E+L+R + S
Sbjct: 205 ALSLNTLPELQSLDEFGQSTDN-------------PQLAHVEAVCIAWFTMEYLLRFLSS 251
Query: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362
P K +F K LN ID +AILP+Y+ + L S S ++V +++ R +RILRI KL
Sbjct: 252 PKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 311
Query: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
RH GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ + T+FK
Sbjct: 312 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDDTKFK 362
Query: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482
+IP FWWA +TMTT+GYGD+YP+T G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 422
Query: 483 AMAKQKLPRKRK 494
++K ++R+
Sbjct: 423 QKRQEKAIKRRE 434
>gi|27436974 potassium voltage-gated channel, Shab-related
subfamily, member 2 [Homo sapiens]
Length = 911
Score = 290 bits (743), Expect = 2e-78
Identities = 181/492 (36%), Positives = 253/492 (51%), Gaps = 91/492 (18%)
Query: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66
+ RV +NVGG HE TL LP TRL L DC T
Sbjct: 34 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR------DCNT------------------ 69
Query: 67 APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126
E C D+ E+FFDRHPG F +LN+YRTGKLH
Sbjct: 70 -----------HESLLEVCD-------DYNLNENEYFFDRHPGAFTSILNFYRTGKLHMM 111
Query: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184
++C F +EL +WGIDE +E CC Y Q ++ EE ET G+ D+
Sbjct: 112 EEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTC 171
Query: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244
KR ++W L E P SS AA+ +A S+ FI++S
Sbjct: 172 CPDKR-----------------------KKLWDLLEKPNSSVAAKILAIVSILFIVLSTI 208
Query: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304
L T P + T Q + + L +VE VC+ WFT E+L+R + S
Sbjct: 209 ALSLNTL-----------PELQETDEFGQ--LNDNRQLAHVEAVCIAWFTMEYLLRFLSS 255
Query: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362
PNK +F K LN+ID +AILP+Y+ + L S S ++V +++ R +RILRI KL
Sbjct: 256 PNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 315
Query: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422
RH GL+ LG TLR S NE LLI+FLA+G++IF++++++AE+ + T+F
Sbjct: 316 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFT 366
Query: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482
+IP FWWA +TMTT+GYGD+YP+T G +VG LC +AGVL IA+P+P+IVNNF +Y
Sbjct: 367 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 426
Query: 483 AMAKQKLPRKRK 494
++K ++R+
Sbjct: 427 QKRQEKAIKRRE 438
>gi|119395748 potassium voltage-gated channel subfamily A member 1
[Homo sapiens]
Length = 495
Score = 258 bits (659), Expect = 1e-68
Identities = 156/388 (40%), Positives = 218/388 (56%), Gaps = 59/388 (15%)
Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
E+FFDR+ F +L YY++G +L P +V +F EE+ F+ +
Sbjct: 79 EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122
Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
EEA++ F + G ++ L K Q ++W LF
Sbjct: 123 --GEEAMEKFREDE--GFIKEEERPLPEKEY---------------------QRQVWLLF 157
Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV--INGTSVVLQYEIE 277
E P SS AR IA S+ IL+SI FCLET K+ T V I+ T+V+ I
Sbjct: 158 EYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIF 217
Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLS---- 333
TDP VE +C++WF+FE +VR P+K +F KN++N ID VAI+P+++ +G
Sbjct: 218 TDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ 276
Query: 334 -GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392
G L LRV+R VR+ RIFKL+RH GL++LG TL+AS E LLI FL +G
Sbjct: 277 EGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 336
Query: 393 VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452
V++F++ +Y+AE A+ + F +IP FWWAVV+MTT+GYGDMYP T G +
Sbjct: 337 VILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKI 387
Query: 453 VGALCALAGVLTIAMPVPVIVNNFGMYY 480
VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 388 VGSLCAIAGVLTIALPVPVIVSNFNYFY 415
>gi|5031819 potassium voltage-gated channel, shaker-related
subfamily, member 10 [Homo sapiens]
Length = 511
Score = 257 bits (656), Expect = 2e-68
Identities = 163/433 (37%), Positives = 237/433 (54%), Gaps = 62/433 (14%)
Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
E+FFDR+ F +L YY++G K+ PA+V +F +E++F+ +
Sbjct: 128 EYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYEL---------------- 171
Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
EA+D F + DP E L L D + + W LF
Sbjct: 172 --GSEAMDQFREDEGFIKDP---ETL----LPTND----------------IHRQFWLLF 206
Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNI---VKNKTEPVINGTSVVLQYEI 276
E P SS AAR +A S+ +++SIT FCLET F +K +P +N + VL +
Sbjct: 207 EYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTM 266
Query: 277 ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYL----EVGL 332
TDP VE C+VWFTFE ++R V P+K +F +N++NIID ++I+P++ E+
Sbjct: 267 FTDPFFM-VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQ 325
Query: 333 SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392
S L LR++R VR+ RIFKL+RH GL++LG TL+AS E LLI FL +G
Sbjct: 326 ETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 385
Query: 393 VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452
V++F++ +Y+AE ++P + F +IP GFWWAVVTMTT+GYGDM P T G +
Sbjct: 386 VILFSSAVYFAE-----VDEPES----HFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKI 436
Query: 453 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAM---AKQKLPRKRKKHIPPAPQASSPTFC 509
VG LCA+AGVLTIA+PVPVIV+NF +Y KQ +P + ++ + T
Sbjct: 437 VGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDS 496
Query: 510 KTELNMACNSTQS 522
+ N C++ +S
Sbjct: 497 LNKTNGGCSTEKS 509
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/30 (50%), Positives = 18/30 (60%)
Query: 5 ENNERVILNVGGTRHETYRSTLKTLPGTRL 34
E N+RVI+N+ G R ET TL P T L
Sbjct: 83 EGNQRVIINIAGLRFETQLRTLSQFPETLL 112
>gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
Length = 647
Score = 251 bits (642), Expect = 9e-67
Identities = 151/438 (34%), Positives = 226/438 (51%), Gaps = 46/438 (10%)
Query: 101 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR 160
E+FFDR P +F +VLN+YRTG+LHCP C F+EELAF+G+ V CC YR +
Sbjct: 81 EYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK 140
Query: 161 DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFE 220
A+RL ++ A G L+ R+W FE
Sbjct: 141 KEN-----------------------AERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFE 177
Query: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDP 280
+P++S AA + + FFI VS+ +ET + + G
Sbjct: 178 NPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERF--------PQ 229
Query: 281 ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAA 340
A ++ CV+ FT E+L+R+ +P++ F+++++++ID VAILP+Y+ GL
Sbjct: 230 AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPKN 284
Query: 341 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 400
DV G +R R+ RIFK +RH GLR+LG+TL++ +E L+ L + ++IFAT++
Sbjct: 285 DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344
Query: 401 YYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALA 460
+YAE+ + T F +IP FW+ +VTMTTLGYGDM P T +G + G++C+L+
Sbjct: 345 FYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLS 395
Query: 461 GVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNST 520
GVL IA+PVPVIV+NF Y K ++K + A S T L N
Sbjct: 396 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGT-TNAFLQYKQNGG 454
Query: 521 QSDTCLGKDNRLLEHNRS 538
D+ G++ L NRS
Sbjct: 455 LEDSGSGEEQALCVRNRS 472
Score = 30.0 bits (66), Expect = 5.8
Identities = 16/35 (45%), Positives = 23/35 (65%), Gaps = 3/35 (8%)
Query: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
+E +++NV G R ET+++TL P T LL SSE
Sbjct: 39 DEVLVVNVSGRRFETWKNTLDRYPDT---LLGSSE 70
>gi|25952092 potassium voltage-gated channel, shaker-related
subfamily, member 7 [Homo sapiens]
Length = 456
Score = 251 bits (642), Expect = 9e-67
Identities = 180/494 (36%), Positives = 243/494 (49%), Gaps = 126/494 (25%)
Query: 8 ERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRA 67
ER++LNV G R ET TL P T L GD
Sbjct: 13 ERLVLNVAGLRFETRARTLGRFPDTLL----------------GDP-------------- 42
Query: 68 PPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTG-KLHCP 126
+R GR D RE+FFDRH F VL YY++G +L P
Sbjct: 43 -------------------ARRGRFYDD--ARREYFFDRHRPSFDAVLYYYQSGGRLRRP 81
Query: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLA 186
A V +F EE+AF+G+ A
Sbjct: 82 AHVPLDVFLEEVAFYGLG-----------------------------------------A 100
Query: 187 AKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTF 246
A + + G P + R ++W LFE P SS+AAR +A S+ ILVSI F
Sbjct: 101 AALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVF 160
Query: 247 CLETHEAFNIVKNKT-----------EPVINGTSVVLQY--EIETDPALTYVEGVCVVWF 293
CLET F ++ T +NG+S + + + VE +C+ WF
Sbjct: 161 CLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWF 220
Query: 294 TFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLS-----GLSSKAAKDVLGFLR 348
+FE LVR++ P+K F KN++N+IDFVAILP+++ +G G+ +A L LR
Sbjct: 221 SFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMS--LAILR 278
Query: 349 VVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAE--RV 406
V+R VR+ RIFKL+RH GL++LG TLRAS E LLI FL +GV++F++ +Y+AE RV
Sbjct: 279 VIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRV 338
Query: 407 GAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIA 466
+ F +IP FWWAVVTMTT+GYGDM P T G +VG+LCA+AGVLTI+
Sbjct: 339 DSH-----------FTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTIS 387
Query: 467 MPVPVIVNNFGMYY 480
+PVPVIV+NF +Y
Sbjct: 388 LPVPVIVSNFSYFY 401
>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
[Homo sapiens]
Length = 494
Score = 251 bits (641), Expect = 1e-66
Identities = 163/489 (33%), Positives = 234/489 (47%), Gaps = 90/489 (18%)
Query: 10 VILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPP 69
+++NVGG R Y L P TRLA L +
Sbjct: 25 IVVNVGGVRQVLYGDLLSQYPETRLAELIN------------------------------ 54
Query: 70 LSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADV 129
C GG S D+ G REF+FDR P F V+ Y G++H +
Sbjct: 55 -------CLAGGYDTIFSL---CDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Query: 130 CGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKR 189
C F+ E+ FW +D ++ CC + R EE +I LI D
Sbjct: 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEKR--EELEEIARRVQLILDD----------- 151
Query: 190 LGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLE 249
LG+ D GRWRR Q +W E P SS AR +A S ILVS C+
Sbjct: 152 LGV---------DAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMG 202
Query: 250 THEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLE 309
T ++ + V + P L VE C+ WFT E+L+R+ SPNKL
Sbjct: 203 TIPELQVLDAEGNRVEH-------------PTLENVETACIGWFTLEYLLRLFSSPNKLH 249
Query: 310 FIKNLLNIIDFVAILPFYLEVGLSGLSSKAAK--DVLGFLRVVRFVRILRIFKLTRHFVG 367
F + +NI+D +AILPFY+ + L+ L ++ + +V ++ +R +RI RIFKL RH G
Sbjct: 250 FALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSG 309
Query: 368 LRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIG 427
L+ L + L+ S E LL+++LA+G+ +F+ + Y E+ + T FK+IP
Sbjct: 310 LQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQ---------SHPETLFKSIPQS 360
Query: 428 FWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQ 487
FWWA++TMTT+GYGD+YP+T G L A+ L GV+ IA+P+ I+NNF YY+ KQ
Sbjct: 361 FWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYN----KQ 416
Query: 488 KLPRKRKKH 496
++ KH
Sbjct: 417 RVLETAAKH 425
>gi|4504817 potassium voltage-gated channel, shaker-related
subfamily, member 4 [Homo sapiens]
Length = 653
Score = 247 bits (630), Expect = 2e-65
Identities = 159/400 (39%), Positives = 223/400 (55%), Gaps = 70/400 (17%)
Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
E+FFDR+ F +L YY++G +L P +V +F EE+ F+ +
Sbjct: 218 EYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQL---------------- 261
Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
EEAL F + G ++ED A + ++W LF
Sbjct: 262 --GEEALLKFREDE---GFVREEEDRALPE-------------------NEFKKQIWLLF 297
Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV--------INGTSVV 271
E P SS AR IA S+ IL+SI FCLET F ++ + +N TS
Sbjct: 298 EYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAP 357
Query: 272 ----LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFY 327
+ I DP VE VC+VWF+FEF+VR P++ F KN++NIID V+ILP++
Sbjct: 358 HLENSGHTIFNDPFFI-VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYF 416
Query: 328 LEVGLS-----GLSSKAAKDVLGF--LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 380
+ +G G + + + F LR++R VR+ RIFKL+RH GL++LGHTLRAS
Sbjct: 417 ITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMR 476
Query: 381 EFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGY 440
E LLI FL +GV++F++ +Y+AE ++P+ T F++IP FWWAVVTMTT+GY
Sbjct: 477 ELGLLIFFLFIGVILFSSAVYFAEA-----DEPT----THFQSIPDAFWWAVVTMTTVGY 527
Query: 441 GDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
GDM P T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 528 GDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 567
>gi|27436984 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 1 [Homo sapiens]
Length = 655
Score = 246 bits (628), Expect = 4e-65
Identities = 156/457 (34%), Positives = 244/457 (53%), Gaps = 65/457 (14%)
Query: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTY--R 157
+E+FFDR P VF VLN+YRTGKLH P C +++ELAF+GI + CC+ Y R
Sbjct: 80 KEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDR 139
Query: 158 QHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217
+ +AE +D D D + + + + MW
Sbjct: 140 KRENAERLMD--------------DNDSENNQESMPSLS--------------FRQTMWR 171
Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
FE+P++S A + + FFI VS+ T +ET + +K P SV
Sbjct: 172 AFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSV------- 224
Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
A ++ CV+ FT E+L+R+ +P++ FI+++++IID VAI+P+Y+ GL
Sbjct: 225 ---AFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----GLVM 276
Query: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397
+DV G +R R+ RIFK +RH GLR+LG+TL++ +E L+ L + ++IFA
Sbjct: 277 TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 336
Query: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457
T+++YAE+ S ++F +IP FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 337 TVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 387
Query: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514
+L+GVL IA+PVPVIV+NF +Y+ A ++ +K+ + I A SS + ++ N
Sbjct: 388 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRN 447
Query: 515 MACN------STQSDTCLGKDNRLLE--HNRSDNCKE 543
N T + +GK L+E H+ +C E
Sbjct: 448 GLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLE 484
Score = 32.0 bits (71), Expect = 1.5
Identities = 16/35 (45%), Positives = 24/35 (68%), Gaps = 3/35 (8%)
Query: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
+E ++LNV G R +T+R+TL+ P T LL S+E
Sbjct: 39 DELIVLNVSGRRFQTWRTTLERYPDT---LLGSTE 70
>gi|27436986 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 2 [Homo sapiens]
Length = 636
Score = 246 bits (628), Expect = 4e-65
Identities = 156/457 (34%), Positives = 244/457 (53%), Gaps = 65/457 (14%)
Query: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTY--R 157
+E+FFDR P VF VLN+YRTGKLH P C +++ELAF+GI + CC+ Y R
Sbjct: 80 KEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDR 139
Query: 158 QHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217
+ +AE +D D D + + + + MW
Sbjct: 140 KRENAERLMD--------------DNDSENNQESMPSLS--------------FRQTMWR 171
Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
FE+P++S A + + FFI VS+ T +ET + +K P SV
Sbjct: 172 AFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSV------- 224
Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
A ++ CV+ FT E+L+R+ +P++ FI+++++IID VAI+P+Y+ GL
Sbjct: 225 ---AFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----GLVM 276
Query: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397
+DV G +R R+ RIFK +RH GLR+LG+TL++ +E L+ L + ++IFA
Sbjct: 277 TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 336
Query: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457
T+++YAE+ S ++F +IP FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 337 TVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 387
Query: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514
+L+GVL IA+PVPVIV+NF +Y+ A ++ +K+ + I A SS + ++ N
Sbjct: 388 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRN 447
Query: 515 MACN------STQSDTCLGKDNRLLE--HNRSDNCKE 543
N T + +GK L+E H+ +C E
Sbjct: 448 GLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLE 484
Score = 32.0 bits (71), Expect = 1.5
Identities = 16/35 (45%), Positives = 24/35 (68%), Gaps = 3/35 (8%)
Query: 7 NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
+E ++LNV G R +T+R+TL+ P T LL S+E
Sbjct: 39 DELIVLNVSGRRFQTWRTTLERYPDT---LLGSTE 70
>gi|4826782 potassium voltage-gated channel, shaker-related
subfamily, member 2 [Homo sapiens]
Length = 499
Score = 246 bits (628), Expect = 4e-65
Identities = 157/399 (39%), Positives = 223/399 (55%), Gaps = 75/399 (18%)
Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
E+FFDR+ F +L YY++G +L P +V +F EE+ F+ +
Sbjct: 75 EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------------- 118
Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
EEA+++F +DE E+ L P+ + Q ++W LF
Sbjct: 119 --GEEAMEMFR----------EDEGYIK-----EEERPL--PENE------FQRQVWLLF 153
Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV----------INGTS 269
E P SS AR IA S+ IL+SI +FCLET F +++ E + N T
Sbjct: 154 EYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSGVTFHTYSNSTI 210
Query: 270 VVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLE 329
Q TDP VE +C++WF+FEFLVR P+K F N++NIID VAI+P+++
Sbjct: 211 GYQQSTSFTDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFIT 269
Query: 330 VGLSGLSSKAAKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 381
+G ++ +D L LRV+R VR+ RIFKL+RH GL++LG TL+AS E
Sbjct: 270 LGTE--LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 327
Query: 382 FLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYG 441
LLI FL +GV++F++ +Y+AE + +QF +IP FWWAVV+MTT+GYG
Sbjct: 328 LGLLIFFLFIGVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYG 378
Query: 442 DMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
DM P T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 379 DMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
>gi|25952108 potassium voltage-gated channel delayed-rectifier
protein S3 [Homo sapiens]
Length = 491
Score = 246 bits (627), Expect = 5e-65
Identities = 154/480 (32%), Positives = 235/480 (48%), Gaps = 82/480 (17%)
Query: 5 ENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPP 64
++ E V LNVGG + +STL P TRL L + L
Sbjct: 12 QDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELC-------------- 57
Query: 65 PRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLH 124
D+ +E++FDR+P +F YVLN+Y TGKLH
Sbjct: 58 ----------------------------DDYSVADKEYYFDRNPSLFRYVLNFYYTGKLH 89
Query: 125 CPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDED 184
++C F +E+ +WGI+E ++ CC Y++ ++ D + + D +E
Sbjct: 90 VMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEES 149
Query: 185 -LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSI 243
L K L D G +L+ ++W E+P +A+ IA +SL +L SI
Sbjct: 150 SLFEKELEKFDTLRFG----------QLRKKIWIRMENPAYCLSAKLIAISSLSVVLASI 199
Query: 244 TTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVF 303
C+ + F + + DP L VE C+ WFT E VR+
Sbjct: 200 VAMCVHSMSEFQNEDGEVD----------------DPVLEGVEIACIAWFTGELAVRLAA 243
Query: 304 SPNKLEFIKNLLNIIDFVAILPFY--LEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKL 361
+P + +F KN LNIIDFV+I+PFY L V S+ +++ ++++R +RI RI KL
Sbjct: 244 APCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKL 303
Query: 362 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQ- 420
RH VGLR LG TLR S +E LL++FL++G+ IF+ +IY E+ +HT
Sbjct: 304 ARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEK----------DDHTSS 353
Query: 421 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
+IPI +WWA ++MTT+GYGD +P T +G L+ + C + G+L +A+P+ +I N F YY
Sbjct: 354 LTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYY 413
>gi|88758565 potassium voltage-gated channel, shaker-related
subfamily, member 3 [Homo sapiens]
Length = 575
Score = 245 bits (626), Expect = 7e-65
Identities = 155/394 (39%), Positives = 215/394 (54%), Gaps = 66/394 (16%)
Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
E+FFDR+ F +L YY++G ++ P +V +F EE+ F+ +
Sbjct: 146 EYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQL---------------- 189
Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
EEA++ F ED L + R R Q ++W LF
Sbjct: 190 --GEEAMEKFR----------------------EDEGFLREEERPLPR-RDFQRQVWLLF 224
Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKN--------KTEPVINGTSVV 271
E P SS AR IA S+ IL+SI FCLET F K+ E N TS
Sbjct: 225 EYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGS 284
Query: 272 LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVG 331
VE +C++WF+FE LVR P+K F +N++N+ID VAI+P+++ +G
Sbjct: 285 RAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLG 344
Query: 332 LS-----GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLI 386
G +A L LRV+R VR+ RIFKL+RH GL++LG TL+AS E LLI
Sbjct: 345 TELAERQGNGQQAMS--LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLI 402
Query: 387 IFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQ 446
FL +GV++F++ +Y+AE +DP++ F +IP FWWAVVTMTT+GYGDM+P
Sbjct: 403 FFLFIGVILFSSAVYFAEA-----DDPTSG----FSSIPDAFWWAVVTMTTVGYGDMHPV 453
Query: 447 TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 454 TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 487
>gi|4504821 potassium voltage-gated channel, shaker-related
subfamily, member 6 [Homo sapiens]
Length = 529
Score = 242 bits (617), Expect = 7e-64
Identities = 161/435 (37%), Positives = 222/435 (51%), Gaps = 107/435 (24%)
Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
E+FFDR+ F +L YY++G +L P +V +F EE+ F+ +
Sbjct: 83 EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLG--------------- 127
Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGL--GGPDGKSGRWRRLQPRMWA 217
DE LAA R ED L GG D K + Q ++W
Sbjct: 128 ----------------------DEALAAFR---EDEGCLPEGGEDEKPLPSQPFQRQVWL 162
Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVK--------NKTEPVINGTS 269
LFE P SS AR IA S+ IL+SI FCLET F + ++ PV G+
Sbjct: 163 LFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQ 222
Query: 270 VVLQYEIETDPALTY-------------------------------VEGVCVVWFTFEFL 298
+ E + D + T+ VE +C+VWFTFE L
Sbjct: 223 ---EEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELL 279
Query: 299 VRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG------------- 345
VR P+K F +N++NIID VAI P+++ +G + + + G
Sbjct: 280 VRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLA 339
Query: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405
LRV+R VR+ RIFKL+RH GL++LG TL+AS E LLI FL +GV++F++ +Y+AE
Sbjct: 340 ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE- 398
Query: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465
+ + + F +IP FWWAVVTMTT+GYGDMYP T G +VG+LCA+AGVLTI
Sbjct: 399 --------ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTI 450
Query: 466 AMPVPVIVNNFGMYY 480
A+PVPVIV+NF +Y
Sbjct: 451 ALPVPVIVSNFNYFY 465
>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
member 2 [Homo sapiens]
Length = 630
Score = 241 bits (614), Expect = 2e-63
Identities = 146/429 (34%), Positives = 235/429 (54%), Gaps = 56/429 (13%)
Query: 100 REFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
+++FFDR P +F ++LN+YRTGKLH P C ++EELAF+G+ + CC+ Y+
Sbjct: 81 QQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDR 140
Query: 160 R--DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWA 217
R +AE D +T D AG + R R+W
Sbjct: 141 RRENAERLQDDADT----------------------DTAGESALPTMTAR-----QRVWR 173
Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
FE+P++S A + + FFI VS+ +ET + + E V + ++
Sbjct: 174 AFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLD 233
Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
T CV+ FT E+L+R+ +P++ F++++++IID VAILP+Y+ GL
Sbjct: 234 T---------ACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVM 279
Query: 338 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 397
+DV G +R R+ RIFK +RH GLR+LG+TL++ +E L+ L + ++IFA
Sbjct: 280 TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
Query: 398 TMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 457
T+++YAE+ S ++F +IP FW+ +VTMTTLGYGDM P+T +G + G++C
Sbjct: 340 TVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
Query: 458 ALAGVLTIAMPVPVIVNNFG-MYYSLAMAKQKLPRKRKK--HIPPAPQASSPTFCKTELN 514
+L+GVL IA+PVPVIV+NF +Y+ A ++ +K+ + I A S+ + +++ N
Sbjct: 391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRN 450
Query: 515 -MACNSTQS 522
+ N QS
Sbjct: 451 GLLSNQLQS 459
Score = 32.0 bits (71), Expect = 1.5
Identities = 16/32 (50%), Positives = 22/32 (68%), Gaps = 3/32 (9%)
Query: 10 VILNVGGTRHETYRSTLKTLPGTRLALLASSE 41
++LNV GTR +T++ TL+ P T LL SSE
Sbjct: 43 IVLNVSGTRFQTWQDTLERYPDT---LLGSSE 71
>gi|25952087 potassium voltage-gated channel, shaker-related
subfamily, member 5 [Homo sapiens]
Length = 613
Score = 238 bits (607), Expect = 1e-62
Identities = 156/413 (37%), Positives = 217/413 (52%), Gaps = 84/413 (20%)
Query: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159
E+FFDR+ F +L YY++G +L P +V +F +E+ F+ +
Sbjct: 162 EYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQL---------------- 205
Query: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219
+EA++ F +DE G + K Q ++W +F
Sbjct: 206 --GDEAMERFR----------EDE-------------GFIKEEEKPLPRNEFQRQVWLIF 240
Query: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE------------PVING 267
E P SS +AR IA S+ IL+SI TFCLET F + P NG
Sbjct: 241 EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG 300
Query: 268 TSVVLQYEIETDPALT---------YVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNII 318
+ V+ T L VE CV+WFTFE LVR P+K F +N++NII
Sbjct: 301 SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII 360
Query: 319 DFVAILPFYLEVGLS-----------GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVG 367
D VAI P+++ +G G + + A L LRV+R VR+ RIFKL+RH G
Sbjct: 361 DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMS-LAILRVIRLVRVFRIFKLSRHSKG 419
Query: 368 LRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIG 427
L++LG TL+AS E LLI FL +GV++F++ +Y+AE + ++ T F +IP
Sbjct: 420 LQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE---------ADNQGTHFSSIPDA 470
Query: 428 FWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480
FWWAVVTMTT+GYGDM P T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 471 FWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 523
>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
Length = 500
Score = 229 bits (585), Expect = 4e-60
Identities = 153/491 (31%), Positives = 238/491 (48%), Gaps = 92/491 (18%)
Query: 12 LNVGGTRHETYRSTLKTLPGTRLALLA----SSEPPGDCLTTAGDKLQPSPPPLSPPPRA 67
+NVGG+R + L P TRL LA S PG L P PL A
Sbjct: 43 VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPG--------ALAAVPSPLELCDDA 94
Query: 68 PPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPA 127
P+ E+FFDR F YVL+YYRTG+LH
Sbjct: 95 NPVD----------------------------NEYFFDRSSQAFRYVLHYYRTGRLHVME 126
Query: 128 DVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAA 187
+C F +E+ +WGIDE ++ CC Y + ++ E LD + D ED +
Sbjct: 127 QLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKK----------DTEDQES 176
Query: 188 KRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFC 247
+ +D + G ++ ++W + E P SS AAR S+ F++VSI
Sbjct: 177 QHESEQDFS--------QGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMA 228
Query: 248 LETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNK 307
L + E + + LQ L +E VC+ WFT EF++R + ++
Sbjct: 229 LMSAEL--------------SWLDLQ-------LLEILEYVCISWFTGEFVLRFLCVRDR 267
Query: 308 LEFIKNLLNIIDFVAILPFYLEVGLSGLS----SKAAKDVLGFLRVVRFVRILRIFKLTR 363
F++ + NIID +AILPFY+ + + LS ++ ++V ++V+R +R LR+ KL R
Sbjct: 268 CRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGR 327
Query: 364 HFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKN 423
H GLR LG T+ E LL++FL++G+ IF+T+ Y+AE+ + T F +
Sbjct: 328 HSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQ---------SIPDTTFTS 378
Query: 424 IPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLA 483
+P +WWA +MTT+GYGD+ P T +G +V +C L+G+L +A+P+ +I + F Y
Sbjct: 379 VPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTL 438
Query: 484 MAKQKLPRKRK 494
K+ R+R+
Sbjct: 439 KLKEAAVRQRE 449
>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
subfamily S, member 2 [Homo sapiens]
Length = 477
Score = 229 bits (585), Expect = 4e-60
Identities = 137/389 (35%), Positives = 205/389 (52%), Gaps = 34/389 (8%)
Query: 94 DHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCW 153
D+ REF+FDR+P +F YVL++Y TGKLH A++C F +E+ +WGI+E ++ CC
Sbjct: 61 DYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCS 120
Query: 154 MTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQP 213
+Y + E E D DE LA DA+ G G +RR
Sbjct: 121 YSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAF----YNDASKFDGQ--PLGNFRR--- 171
Query: 214 RMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQ 273
++W ++P S +R + S+ ++ SI T CL + F I ++ P
Sbjct: 172 QLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNP---------- 221
Query: 274 YEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFY--LEVG 331
DP VE + WFTFE + R +P+ L+F KN LN+ID ++I+PFY L V
Sbjct: 222 ---GEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVN 278
Query: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
L S+ ++ +V+R +RI RI KL RH GLR LG TL+ S E LL+++L++
Sbjct: 279 LVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSV 338
Query: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451
G+ IF+ + Y E+ E+ IP +WWA V+MTT+GYGD+ P T +G
Sbjct: 339 GISIFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGK 388
Query: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYY 480
L + C LAG+L + +P+ +I N F +Y
Sbjct: 389 LTASACILAGILVVVLPITLIFNKFSHFY 417
>gi|13492973 potassium voltage-gated channel delayed-rectifier
protein S1 [Homo sapiens]
Length = 526
Score = 223 bits (567), Expect = 5e-58
Identities = 148/483 (30%), Positives = 225/483 (46%), Gaps = 74/483 (15%)
Query: 6 NNERVILNVGGTRHETYRSTLKTLPGTRLALL--ASSEPPGDCLTTAGDKLQPSPPPLSP 63
++E + +NVGG R + L PGTRL L A+SE L
Sbjct: 48 SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRL---------------- 91
Query: 64 PPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKL 123
D+ REF+FDRHPG F +L++YRTG L
Sbjct: 92 ----------------------------CDDYDEAAREFYFDRHPGFFLSLLHFYRTGHL 123
Query: 124 HCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL--DIFETPDLIGGDPGD 181
H ++C F +E +WG+ E + CC Y + R + + +TP + DP
Sbjct: 124 HVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSV--DPCP 181
Query: 182 DEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILV 241
DE +R + A G + R RL+ R+W E+P S ++ + S+ +L
Sbjct: 182 DEISDVQR----ELARYG-----AARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLA 232
Query: 242 SITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRI 301
SI C+ + + + V + + DP L +E C+ WF+FE R+
Sbjct: 233 SIAAMCIHSLPEYQ-AREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRL 291
Query: 302 VFSPNKLEFIKNLLNIIDFVAILPFYLE----VGLSGLSSKAAKDVLGFLRVVRFVRILR 357
+ +P+ F + LN+ID V++LPFYL V L K + ++V R +RI R
Sbjct: 292 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFR 351
Query: 358 IFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASE 417
+ KL RH GLR LG TL+ S E +L+++LA+GV +F+ + Y AE+ E
Sbjct: 352 VLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK----------EE 401
Query: 418 HTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFG 477
F IP +WW V+MTT+GYGD+ P T +G L + C L G+L +A+P+ +I N F
Sbjct: 402 DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFS 461
Query: 478 MYY 480
+Y
Sbjct: 462 HFY 464
>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
[Homo sapiens]
Length = 513
Score = 217 bits (553), Expect = 2e-56
Identities = 145/486 (29%), Positives = 223/486 (45%), Gaps = 88/486 (18%)
Query: 5 ENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPP 64
+ R+I+NVGG ++ +TL P TRL L + D L
Sbjct: 60 DRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVC-------------- 105
Query: 65 PRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLH 124
D+ EFFFDR+PG F +L + R GKL
Sbjct: 106 ----------------------------DDYDVTCNEFFFDRNPGAFGTILTFLRAGKLR 137
Query: 125 CPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH-RDAEEALDIFETPDLIGGDPGDDE 183
++C F+EEL +WGI E ++ CC Y Q + E ++ E D + + D E
Sbjct: 138 LLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSE 197
Query: 184 DLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSI 243
GP GR R R+ + E P+S + A S+ F+ V+
Sbjct: 198 ----------------GPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTA 241
Query: 244 TTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVF 303
+ T + + E G + + + VE VCV WF+ EFL+R++
Sbjct: 242 VNLSVST------LPSLREEEEQGHCSQMCHNV------FIVESVCVGWFSLEFLLRLIQ 289
Query: 304 SPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG---------FLRVVRFVR 354
+P+K F+++ L +ID VAILP+Y+ + + G ++ K G LRV+R +R
Sbjct: 290 APSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALR 349
Query: 355 ILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPS 414
IL + +L RH +GL+ LG T R T EF LL++FL + + +FA ++Y E
Sbjct: 350 ILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIEN--------E 401
Query: 415 ASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN 474
++ +F +IP +WWAV+TMTT+GYGDM P++ G +V L+G+L +A PV I +
Sbjct: 402 MADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFH 461
Query: 475 NFGMYY 480
F Y
Sbjct: 462 TFSRSY 467
>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
[Homo sapiens]
Length = 466
Score = 210 bits (534), Expect = 3e-54
Identities = 139/447 (31%), Positives = 219/447 (48%), Gaps = 64/447 (14%)
Query: 101 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR 160
EFFFDR P F ++ R GKL C F +ELA+WGIDE +E CC R+
Sbjct: 68 EFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRR- 126
Query: 161 DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPD---GKSGRWRRLQPRMWA 217
+E+ A R G + G P G GR +R + R+
Sbjct: 127 ---------------------EEEAAEARAGPTERGAQGSPARALGPRGRLQRGRRRLRD 165
Query: 218 LFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIE 277
+ ++P+S A + A S+ F+ V+ CL T + + E S+ +
Sbjct: 166 VVDNPHSGLAGKLFACVSVSFVAVTAVGLCLSTMPDIRAEEERGECSPKCRSLFV----- 220
Query: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSS 337
+E VCV WF+FEFL+R + + +K F++ LNIID +A+LPFY+ + L +
Sbjct: 221 -------LETVCVAWFSFEFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAG 273
Query: 338 KAAKDVLG----FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGV 393
+L LR++R +R+L + +L RH +GLR LG T+R EF LL++FL + +
Sbjct: 274 PGGTKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAM 333
Query: 394 LIFATMIYYAER-VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452
+FA +++ AER +GA+ + F ++P +WWAV++MTT+GYGDM P++ G +
Sbjct: 334 ALFAPLVHLAERELGARRD---------FSSVPASYWWAVISMTTVGYGDMVPRSLPGQV 384
Query: 453 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTE 512
V L+G+L +A PV I + F YS +Q+ +A+SP E
Sbjct: 385 VALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQ-------------RAASPEPALQE 431
Query: 513 LNMACNSTQSDTCLGKDNRLLEHNRSD 539
+ + D+ G D+ L + +D
Sbjct: 432 DSTHSATATEDSSQGPDSAGLADDSAD 458
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,417,227
Number of Sequences: 37866
Number of extensions: 1380307
Number of successful extensions: 14884
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 300
Number of HSP's successfully gapped in prelim test: 255
Number of HSP's that attempted gapping in prelim test: 11255
Number of HSP's gapped (non-prelim): 2821
length of query: 558
length of database: 18,247,518
effective HSP length: 107
effective length of query: 451
effective length of database: 14,195,856
effective search space: 6402331056
effective search space used: 6402331056
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.