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Search of human proteins with 24497453
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24497453 nucleoporin 88kDa [Homo sapiens]
(741 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24497453 nucleoporin 88kDa [Homo sapiens] 1504 0.0
gi|94721321 coiled-coil domain containing 11 [Homo sapiens] 49 2e-05
gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens] 48 4e-05
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 46 1e-04
gi|58530840 desmoplakin isoform I [Homo sapiens] 45 2e-04
gi|71061468 centromere protein E [Homo sapiens] 45 2e-04
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 44 4e-04
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 44 5e-04
gi|148746195 trichohyalin [Homo sapiens] 44 5e-04
gi|55770834 centromere protein F [Homo sapiens] 43 0.001
gi|41352705 kinesin family member 3C [Homo sapiens] 43 0.001
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 43 0.001
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 43 0.001
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 42 0.002
gi|224451082 cytospin A [Homo sapiens] 42 0.003
gi|224451080 cytospin A [Homo sapiens] 42 0.003
gi|46249351 homer 2 isoform 2 [Homo sapiens] 42 0.003
gi|46249349 homer 2 isoform 1 [Homo sapiens] 42 0.003
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 41 0.004
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 41 0.004
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 41 0.004
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 41 0.004
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 41 0.005
gi|112734867 retinitis pigmentosa GTPase regulator interacting p... 41 0.005
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 41 0.005
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 41 0.005
gi|216548091 leucine zipper protein 1 [Homo sapiens] 41 0.005
gi|216548085 leucine zipper protein 1 [Homo sapiens] 41 0.005
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 41 0.005
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 41 0.005
>gi|24497453 nucleoporin 88kDa [Homo sapiens]
Length = 741
Score = 1504 bits (3893), Expect = 0.0
Identities = 741/741 (100%), Positives = 741/741 (100%)
Query: 1 MAAAEGPVGDGELWQTWLPNHVVFLRLREGLKNQSPTEAEKPASSSLPSSPPPQLLTRNV 60
MAAAEGPVGDGELWQTWLPNHVVFLRLREGLKNQSPTEAEKPASSSLPSSPPPQLLTRNV
Sbjct: 1 MAAAEGPVGDGELWQTWLPNHVVFLRLREGLKNQSPTEAEKPASSSLPSSPPPQLLTRNV 60
Query: 61 VFGLGGELFLWDGEDSSFLVVRLRGPSGGGEEPALSQYQRLLCINPPLFEIYQVLLSPTQ 120
VFGLGGELFLWDGEDSSFLVVRLRGPSGGGEEPALSQYQRLLCINPPLFEIYQVLLSPTQ
Sbjct: 61 VFGLGGELFLWDGEDSSFLVVRLRGPSGGGEEPALSQYQRLLCINPPLFEIYQVLLSPTQ 120
Query: 121 HHVALIGIKGLMVLELPKRWGKNSEFEGGKSTVNCSTTPVAERFFTSSTSLTLKHAAWYP 180
HHVALIGIKGLMVLELPKRWGKNSEFEGGKSTVNCSTTPVAERFFTSSTSLTLKHAAWYP
Sbjct: 121 HHVALIGIKGLMVLELPKRWGKNSEFEGGKSTVNCSTTPVAERFFTSSTSLTLKHAAWYP 180
Query: 181 SEILDPHVVLLTSDNVIRIYSLREPQTPTNVIILSEAEEESLVLNKGRAYTASLGETAVA 240
SEILDPHVVLLTSDNVIRIYSLREPQTPTNVIILSEAEEESLVLNKGRAYTASLGETAVA
Sbjct: 181 SEILDPHVVLLTSDNVIRIYSLREPQTPTNVIILSEAEEESLVLNKGRAYTASLGETAVA 240
Query: 241 FDFGPLAAVPKTLFGQNGKDEVVAYPLYILYENGETFLTYISLLHSPGNIGKLLGPLPMH 300
FDFGPLAAVPKTLFGQNGKDEVVAYPLYILYENGETFLTYISLLHSPGNIGKLLGPLPMH
Sbjct: 241 FDFGPLAAVPKTLFGQNGKDEVVAYPLYILYENGETFLTYISLLHSPGNIGKLLGPLPMH 300
Query: 301 PAAEDNYGYDACAVLCLPCVPNILVIATESGMLYHCVVLEGEEEDDHTSEKSWDSRIDLI 360
PAAEDNYGYDACAVLCLPCVPNILVIATESGMLYHCVVLEGEEEDDHTSEKSWDSRIDLI
Sbjct: 301 PAAEDNYGYDACAVLCLPCVPNILVIATESGMLYHCVVLEGEEEDDHTSEKSWDSRIDLI 360
Query: 361 PSLYVFECVELELALKLASGEDDPFDSDFSCPVKLHRDPKCPSRYHCTHEAGVHSVGLTW 420
PSLYVFECVELELALKLASGEDDPFDSDFSCPVKLHRDPKCPSRYHCTHEAGVHSVGLTW
Sbjct: 361 PSLYVFECVELELALKLASGEDDPFDSDFSCPVKLHRDPKCPSRYHCTHEAGVHSVGLTW 420
Query: 421 IHKLHKFLGSDEEDKDSLQELSTEQKCFVEHILCTKPLPCRQPAPIRGFWIVPDILGPTM 480
IHKLHKFLGSDEEDKDSLQELSTEQKCFVEHILCTKPLPCRQPAPIRGFWIVPDILGPTM
Sbjct: 421 IHKLHKFLGSDEEDKDSLQELSTEQKCFVEHILCTKPLPCRQPAPIRGFWIVPDILGPTM 480
Query: 481 ICITSTYECLIWPLLSTVHPASPPLLCTREDVEVAESPLRVLAETPDSFEKHIRSILQRS 540
ICITSTYECLIWPLLSTVHPASPPLLCTREDVEVAESPLRVLAETPDSFEKHIRSILQRS
Sbjct: 481 ICITSTYECLIWPLLSTVHPASPPLLCTREDVEVAESPLRVLAETPDSFEKHIRSILQRS 540
Query: 541 VANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKK 600
VANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKK
Sbjct: 541 VANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKK 600
Query: 601 QLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERD 660
QLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERD
Sbjct: 601 QLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERD 660
Query: 661 MKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKE 720
MKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKE
Sbjct: 661 MKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKE 720
Query: 721 EGEHIREMVKQINDIRNHVNF 741
EGEHIREMVKQINDIRNHVNF
Sbjct: 721 EGEHIREMVKQINDIRNHVNF 741
>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
Length = 514
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/165 (23%), Positives = 82/165 (49%), Gaps = 10/165 (6%)
Query: 574 EQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEA---K 630
EQ +LK+ AK+E + ++ ++ + ++ Y E+ +++ + L D EEA K
Sbjct: 271 EQDMLKKQKAKQETRTILQKALQERIEHIQQ-EYRDEQDLNMKLVQRALQDLQEEADKKK 329
Query: 631 EKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLI--PDQLRHLGNAIKQVTMKKDY 688
+K+ED++ K +H L + E+ +KE I D+ + L K++ ++K+
Sbjct: 330 QKREDMIREQK----IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEA 385
Query: 689 QQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQIN 733
++Q +++V+ K + + Q E +HI E +K++N
Sbjct: 386 RRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELN 430
Score = 36.2 bits (82), Expect = 0.11
Identities = 37/167 (22%), Positives = 75/167 (44%), Gaps = 13/167 (7%)
Query: 570 QVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEA 629
Q FRE+ ++L E + K +C+++K Q+ ++ +M +L ++ A
Sbjct: 155 QQFRERC---EELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLA 211
Query: 630 KEKQE-DIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDY 688
KEK+E R K+L+ + L S + ++ QL+ ++ L + +K +
Sbjct: 212 KEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVES-NNAQIKHEN 270
Query: 689 QQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQINDI 735
+Q ++K + + IL Q L+E EHI++ + D+
Sbjct: 271 EQDMLKKQKAKQETRTIL--------QKALQERIEHIQQEYRDEQDL 309
>gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]
Length = 388
Score = 47.8 bits (112), Expect = 4e-05
Identities = 52/252 (20%), Positives = 111/252 (44%), Gaps = 31/252 (12%)
Query: 508 TREDVEVAESPLRV-LAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLS 566
TRE+V ++ + L S E+ ++ Q+ +++ + + E ++A + L
Sbjct: 55 TREEVLTLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFE 114
Query: 567 RATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSY------------CREERKS 614
+F+E+ L+ D+ KE+ Q ++ + KK+ E+L R+E +
Sbjct: 115 EQALLFKEETKLQLDIEKEKHQDVIQ----KYKKEQEELQMKISDLITGATRDLRQEVTT 170
Query: 615 LREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDS----ERDMKKELQLIPD 670
L+E + +Y E +E + +K L+ F S L DS +++KE++ D
Sbjct: 171 LKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSD 230
Query: 671 QLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSI-LKEEGEHIREMV 729
+L+ + + Q + + + Q + E T + +R+C + L E RE +
Sbjct: 231 ELKRV--MLAQTQLIEQFNQSQEEN-------TFLQETVRRECEERFELTEALSQAREQL 281
Query: 730 KQINDIRNHVNF 741
+++ +R + F
Sbjct: 282 LELSKLRGSLPF 293
Score = 32.3 bits (72), Expect = 1.6
Identities = 29/154 (18%), Positives = 73/154 (47%), Gaps = 15/154 (9%)
Query: 559 EECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREM 618
E+ L + + +E+ +K+ +E+I+RR+ L ++ + L+ REE +L+
Sbjct: 7 EDSLMTCQQIYKALQEELTVKEK-QEEDIKRRINLAENELEITKTLLNQTREEVLTLKNE 65
Query: 619 AERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNA 678
E + ++++ E+ ++ + + +LSD K E +L ++ +HL
Sbjct: 66 RELMLISHQKSIEQLQETLRQ------------KLLSDDNWKEKIEAELAKERAQHLVEF 113
Query: 679 IKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRK 712
+Q + K ++ K++ + K ++ Y+++
Sbjct: 114 EEQALLFK--EETKLQLDIEKEKHQDVIQKYKKE 145
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/179 (21%), Positives = 82/179 (45%), Gaps = 29/179 (16%)
Query: 564 LLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQL---EDLSYCREERKSLREMAE 620
L + QV ++QY + + +E+ C+Q+K+ L +++ + + + EM E
Sbjct: 626 LWTEKLQVLKQQYQTEMEKLREK--------CEQEKETLLKDKEIIF----QAHIEEMNE 673
Query: 621 RLADKYEEAKEKQEDIMNRMKKLL---HSFHSELPVLSDSERDMKKELQL-IPDQLRHLG 676
+ +K + + + E + + + ++L H EL VL D MK+EL+ + +Q H
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ 733
Query: 677 NAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQINDI 735
+ + + + Q+ EK L Q ++ +LKE +H++E + ++
Sbjct: 734 QQVDSIIKEHEVSIQRTEKALK----------DQINQLELLLKERDKHLKEHQAHVENL 782
Score = 37.4 bits (85), Expect = 0.051
Identities = 39/168 (23%), Positives = 74/168 (44%), Gaps = 24/168 (14%)
Query: 548 KASEKDIAPPPEECLQLLSRATQVFREQYIL------------------KQDLAKEEIQR 589
K EK++A +E + L + F+EQ + ++ LA EE++
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 590 RVKLLCDQKKKQLEDLSYCREE-RKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFH 648
+ K + + + +L DL E R + E+ L +E K + +D+ ++ + +
Sbjct: 543 QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602
Query: 649 SELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
E+ V+ + K EL+ + Q L QV +K+ YQ + MEK+
Sbjct: 603 KEITVMVEKH---KTELESLKHQQDALWTEKLQV-LKQQYQTE-MEKL 645
Score = 34.7 bits (78), Expect = 0.33
Identities = 42/193 (21%), Positives = 88/193 (45%), Gaps = 20/193 (10%)
Query: 508 TREDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSR 567
T E + E L L + E R +L + VA ++A +KD+ C +L +
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLETE-RILLTKQVAE---VEAQKKDV------CTELDAH 859
Query: 568 ATQVFREQYILKQDLAKE--EIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADK 625
QV L Q L K+ E++++VK L + +LED + +E+ K + E + +
Sbjct: 860 KIQV----QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
Query: 626 YEEAKEKQEDIM-NRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTM 684
E ++K+ +I+ ++ S H ++ +K+++ + + + + +K+ +
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
Query: 685 KKDYQQQKMEKVL 697
Q+ K++K L
Sbjct: 976 D---QEAKLKKEL 985
Score = 33.9 bits (76), Expect = 0.56
Identities = 47/220 (21%), Positives = 101/220 (45%), Gaps = 20/220 (9%)
Query: 521 VLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQ 580
V+AET ++ + L+ A L++ K + EE + ++ + E+
Sbjct: 365 VIAET----KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL 420
Query: 581 DLAK--EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEA-KEKQEDIM 637
A+ EE +R++K D++ K +E S EER SL++ R+ + + K+ E+ +
Sbjct: 421 STAQKTEEARRKLKAEMDEQIKTIEKTS--EEERISLQQELSRVKQEVVDVMKKSSEEQI 478
Query: 638 NRMKKL----LHSFHSEL-PVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQK 692
+++KL L EL L ER+ ++++++ L + +++ +K+ Q+
Sbjct: 479 AKLQKLHEKELARKEQELTKKLQTREREFQEQMKV---ALEKSQSEYLKISQEKEQQESL 535
Query: 693 MEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQI 732
+ L L K I+ + + L++E E R + ++
Sbjct: 536 ALEELELQKKAILTESENK---LRDLQQEAETYRTRILEL 572
Score = 33.9 bits (76), Expect = 0.56
Identities = 32/141 (22%), Positives = 76/141 (53%), Gaps = 18/141 (12%)
Query: 574 EQYILKQDLAKEEIQRRVKLL--CDQKKKQ-----LEDLSYCREERKSLREMAER----- 621
++ + +++L + +++++K L C ++K+ +E+L+ E+ ++L++M R
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898
Query: 622 LADKYEEAKEKQEDIMNRMKKLLHSFHSELPV-LSDSERDMKK---ELQLIPDQLRHLGN 677
L ++ E K K + ++ + + H++L L+ +ER+ +K E+ + LR L
Sbjct: 1899 LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
Query: 678 AIKQVT--MKKDYQQQKMEKV 696
+Q +KK+Y Q++ EK+
Sbjct: 1959 EHQQELEILKKEYDQEREEKI 1979
Score = 33.1 bits (74), Expect = 0.96
Identities = 27/133 (20%), Positives = 61/133 (45%), Gaps = 29/133 (21%)
Query: 585 EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLL 644
E +Q+RVK +Q L C+E +S +E L + E +E+ ++ + ++K+
Sbjct: 282 ETLQQRVK-------RQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
Query: 645 HSFHSELP----------------------VLSDSERDMKKELQLIPDQLRHLGNAIKQV 682
+E V+++++R M + L++ +++ L + IKQ+
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
Query: 683 TMKKDYQQQKMEK 695
T + + +++ EK
Sbjct: 395 TTQGEELREQKEK 407
Score = 30.8 bits (68), Expect = 4.7
Identities = 29/129 (22%), Positives = 62/129 (48%), Gaps = 20/129 (15%)
Query: 588 QRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYE-EAKEKQEDIMNRMKKLLHS 646
+ +++ L + +++L D+ E K L + AE L + +E + +EK++++ +K+L
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWE--KKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL-- 1081
Query: 647 FHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEK---VLSLPKPT 703
+ + +M KE+ + ++ +KQ T + Q+Q +K V SL +
Sbjct: 1082 ------LFGCEKEEMNKEITWLKEE------GVKQDTTLNELQEQLKQKSAHVNSLAQDE 1129
Query: 704 IILSAYQRK 712
L A+ K
Sbjct: 1130 TKLKAHLEK 1138
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 45.1 bits (105), Expect = 2e-04
Identities = 47/220 (21%), Positives = 94/220 (42%), Gaps = 11/220 (5%)
Query: 521 VLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQ 580
+L E D ++I +L RS FL K + E L+L + +V E+ L +
Sbjct: 992 ILQEAADVHARYIE-LLTRSGDYYRFLSEMLKSL-----EDLKLKNTKIEVLEEELRLAR 1045
Query: 581 DLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRM 640
D E + K L +K + S + + SL E+ + + AK+ + ++
Sbjct: 1046 DANSENCNKN-KFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQI 1104
Query: 641 KKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLP 700
K+L + ++ L+ D K+ + + D+ N Q+ + +++ +
Sbjct: 1105 KEL----NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES 1160
Query: 701 KPTIILSAYQRKCIQSILKEEGEHIREMVKQINDIRNHVN 740
+ I Y+ + ++ +L+EEG RE ++ +RNH N
Sbjct: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
Score = 37.0 bits (84), Expect = 0.066
Identities = 47/206 (22%), Positives = 94/206 (45%), Gaps = 31/206 (15%)
Query: 559 EECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLS---------YCR 609
+E +L +V +E+ + QD+ + Q +K L QK+K E+L+ C+
Sbjct: 1533 QELTRLRIDYERVSQERTVKDQDITR--FQNSLKELQLQKQKVEEELNRLKRTASEDSCK 1590
Query: 610 EE---------RKSLREMA---ERLADKYEEA---KEKQEDIMNRMKKLLHSFHSELPVL 654
+ R+SL+E A L + E+A K++ ED + + + +L E
Sbjct: 1591 RKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRT 1650
Query: 655 SDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKME-KVLSLPKPTIILSAYQRKC 713
+ R + E++ + QL ++KQ ++ ++ Q+ +E K SL + I + Q
Sbjct: 1651 QEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ-SL 1709
Query: 714 IQSILKEE---GEHIREMVKQINDIR 736
+++ KE E +R + + +D+R
Sbjct: 1710 TENLTKEHLMLEEELRNLRLEYDDLR 1735
Score = 31.2 bits (69), Expect = 3.6
Identities = 30/134 (22%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 609 REERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLI 668
+ ER++LR+ E+ + EA + ++ N+ +++ S L + E+D K LQ +
Sbjct: 1774 QRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD-KARLQRL 1832
Query: 669 PDQLRHLGNAIK---QVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHI 725
D+L + ++ +V + + ++Q+++ L+ K + Y RK ++I K E E
Sbjct: 1833 EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWK-----TQYSRK-EEAIRKIESER- 1885
Query: 726 REMVKQINDIRNHV 739
+ ++ N +R+ +
Sbjct: 1886 EKSEREKNSLRSEI 1899
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/237 (23%), Positives = 103/237 (43%), Gaps = 41/237 (17%)
Query: 524 ETPDSFEKHIRSILQRS---VANPAFLKASEKD---------IAPPPEECLQLLSRATQV 571
ET D F++ + I ++ N L A KD I +E +L V
Sbjct: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESV 1062
Query: 572 FREQYILKQDLAKE-----EIQRRVKLLCDQKKKQLEDLSYCREER-----------KSL 615
E+ LK DL + E Q ++LL D+ KKQ E ++ + L
Sbjct: 1063 IAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRL 1122
Query: 616 REMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHL 675
E+ E+L +K ++ +EKQ+ ++N +++ SE+ + ++K EL+ L H+
Sbjct: 1123 AEVEEKLKEKSQQLQEKQQQLLNVQEEM-----SEMQKKINEIENLKNELKNKELTLEHM 1177
Query: 676 GNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQI 732
++ K + + E+V S+ K +L K +Q + E +H+R +++I
Sbjct: 1178 ETERLELAQKLN---ENYEEVKSITKERKVL-----KELQKSFETERDHLRGYIREI 1226
Score = 38.5 bits (88), Expect = 0.023
Identities = 37/206 (17%), Positives = 91/206 (44%), Gaps = 7/206 (3%)
Query: 521 VLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQ 580
VL D +++I+ I+ + + LK + + E +L ++ E +++
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 581 DLA--KEEIQRRVKLLCDQKKK-QLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIM 637
L +++Q +++ + +++++ ++ +S +E+ L++ E K + A + E M
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK-DSALQSIESKM 1571
Query: 638 NRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVL 697
+ L E+ ++ + +MK+ + + + L K++ K Q+K + L
Sbjct: 1572 LELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFL 1631
Query: 698 SLPKPTIILSAYQRKCIQSILKEEGE 723
K T + ++ C LKE+ E
Sbjct: 1632 ---KMTAVNETQEKMCEIEHLKEQFE 1654
Score = 35.8 bits (81), Expect = 0.15
Identities = 36/194 (18%), Positives = 89/194 (45%), Gaps = 23/194 (11%)
Query: 570 QVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEA 629
+ +E +K D KE I+ + + + + KQ + L+ ++ ++ + ++E K +++
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414
Query: 630 KEKQEDI-MNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK--- 685
+ +I M + K L H E+ ++ + D+++ +++ + L IK++ K
Sbjct: 1415 ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLE 1474
Query: 686 ------------KDYQQQKMEKVLSLPKPTIILSAYQR--KCIQSILKEEGEHIREM--- 728
K+ ++ E ++L + +S Q+ + I L+ + + I E
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534
Query: 729 --VKQINDIRNHVN 740
+KQI++++ VN
Sbjct: 1535 FNIKQISEVQEKVN 1548
Score = 33.9 bits (76), Expect = 0.56
Identities = 26/151 (17%), Positives = 71/151 (47%), Gaps = 1/151 (0%)
Query: 547 LKASEKDIAPPPEECLQLLSRATQVFR-EQYILKQDLAKEEIQRRVKLLCDQKKKQLEDL 605
LKA+E + ++ + + +++ + ++ I Q L +++ L + + LE++
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
Query: 606 SYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKEL 665
+ER +LR + E L + ++ KE ++ R ++ + + + + + K
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 666 QLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
+ I ++ + + K + KD Q+K++++
Sbjct: 1945 EKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975
Score = 31.2 bits (69), Expect = 3.6
Identities = 33/174 (18%), Positives = 80/174 (45%), Gaps = 25/174 (14%)
Query: 585 EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQ----------- 633
+E Q ++++ +K++ + ER L+E + + K +E++EK+
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 634 -EDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQK 692
++ M ++ L F ++ L + E + + Q++ + L + + VT ++D +
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM----RSVTKERD-DLRS 1693
Query: 693 MEKVLSLPKPTIILSAYQRKCIQSILKEEGE------HIREMVKQINDIRNHVN 740
+E+ L + + L R+ I L+++ E H++E + I+ +R V+
Sbjct: 1694 VEETLKVERDQ--LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS 1745
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 44.3 bits (103), Expect = 4e-04
Identities = 52/212 (24%), Positives = 91/212 (42%), Gaps = 24/212 (11%)
Query: 510 EDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRAT 569
+D+ ES + L F++H LQ SV N L E + EE QL +
Sbjct: 1145 QDILEKESIILKLERNLKEFQEH----LQDSVKNTKDLNVKELKLK---EEITQLTNNLQ 1197
Query: 570 QVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEA 629
+ +++L+ +EE R+ + +K E+LS ++L+ +R + Y +
Sbjct: 1198 DM---KHLLQLKEEEEETNRQ------ETEKLKEELSASSARTQNLKADLQRKEEDYADL 1248
Query: 630 KEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQ 689
KEK D KK + E+ V+ RD K L++ ++L N Q K
Sbjct: 1249 KEKLTD----AKKQIKQVQKEVSVM----RDEDKLLRIKINELEKKKNQCSQELDMKQRT 1300
Query: 690 QQKMEKVLSLPKPTIILSAYQRKCIQSILKEE 721
Q++++ L+ K + Y+R C +KE+
Sbjct: 1301 IQQLKEQLNNQKVEEAIQQYERACKDLNVKEK 1332
Score = 35.4 bits (80), Expect = 0.19
Identities = 27/112 (24%), Positives = 55/112 (49%), Gaps = 15/112 (13%)
Query: 596 DQKKKQ--------LEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSF 647
DQKK + +ED+ +E + LR + ++ + KE++ ++ K+++H F
Sbjct: 820 DQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAEL---NKQIVH-F 875
Query: 648 HSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSL 699
EL + + KE+Q I + AI ++ ++K Q++ EK++ L
Sbjct: 876 QQELSLSEKKNLTLSKEVQQIQS---NYDIAIAELHVQKSKNQEQEEKIMKL 924
Score = 31.6 bits (70), Expect = 2.8
Identities = 41/178 (23%), Positives = 73/178 (41%), Gaps = 23/178 (12%)
Query: 509 REDVEVAESPLRVLAETPDSFEKHIRSILQRSVA----NPAFLKASEKDIAPPPEECLQL 564
+ D++ E L E +K I+ + Q+ V+ L+ ++ +C Q
Sbjct: 1235 KADLQRKEEDYADLKEKLTDAKKQIKQV-QKEVSVMRDEDKLLRIKINELEKKKNQCSQE 1293
Query: 565 LS---RATQVFREQYILKQDLAKEEIQRRVKLLCDQ--KKKQLEDLSYCREERKSLR--- 616
L R Q +EQ L +E IQ+ + D K+K +ED+ EE++ +
Sbjct: 1294 LDMKQRTIQQLKEQ--LNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQ 1351
Query: 617 --------EMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQ 666
E ERLA + E+ KEK D+ + + + H + +++ ELQ
Sbjct: 1352 DQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQ 1409
Score = 31.2 bits (69), Expect = 3.6
Identities = 41/211 (19%), Positives = 97/211 (45%), Gaps = 33/211 (15%)
Query: 550 SEKDIAPPPEECLQLLSRATQVFRE--QYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSY 607
SE+D P + L LL V ++ +Y +++ + ++ + ++ K+ ++ S
Sbjct: 976 SEEDNLPNTQ--LDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1033
Query: 608 CREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSE---RDMKKE 664
+ + L + E+L + + K++ NR+K+ H +L L + E + +K+E
Sbjct: 1034 KSHQIEELEQQIEKLQAEVKGYKDEN----NRLKEKEHKNQDDL--LKEKETLIQQLKEE 1087
Query: 665 LQ----LIPDQLRHL---GNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSI 717
LQ + Q++H+ A+ ++T + K++++ ++ + + ++ K Q I
Sbjct: 1088 LQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDI 1147
Query: 718 LKEEG-------------EHIREMVKQINDI 735
L++E EH+++ VK D+
Sbjct: 1148 LEKESIILKLERNLKEFQEHLQDSVKNTKDL 1178
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/214 (20%), Positives = 102/214 (47%), Gaps = 20/214 (9%)
Query: 530 EKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEEIQR 589
E+ +R +R L+ E+ + E + R + +E+ + +Q+ E ++
Sbjct: 198 EERLREQEERLREQEERLREQEERLCEQEERLREQEERLRE--QEERLCEQE---ERLRE 252
Query: 590 RVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHS 649
+ LC+Q+++ E RE+ + L E ERL ++ E +E++E + + ++L
Sbjct: 253 HEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLR---EQ 309
Query: 650 ELPVLSDSERDMKKELQL-----IPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTI 704
E + ER ++E +L +P Q R L K ++++ +Q++ E++L +
Sbjct: 310 EERLCEQEERLREQEERLCEQEKLPGQERLLEEVEK--LLEQERRQEEQERLLERER--- 364
Query: 705 ILSAYQRKCIQSILKEEGEHI--REMVKQINDIR 736
+L + Q L+++ E + +E ++++ +R
Sbjct: 365 LLEEVEELLEQERLRQQDERLWQQETLQELERLR 398
Score = 33.5 bits (75), Expect = 0.73
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 4/118 (3%)
Query: 530 EKHIRSILQRSVANPAFLKASEKDIAPP--PEECLQLLSRATQVFRE-QYILKQDLAKEE 586
E H+ L RS+ A PP P + QL + +E + + +Q A+ E
Sbjct: 126 EIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVE 185
Query: 587 IQRRVKLLCDQKKKQL-EDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKL 643
+ + LL +++++L E RE+ + LRE ERL ++ E +E++E + + ++L
Sbjct: 186 NNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERL 243
Score = 32.0 bits (71), Expect = 2.1
Identities = 30/144 (20%), Positives = 72/144 (50%), Gaps = 7/144 (4%)
Query: 588 QRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSF 647
+R+ + L +Q+++ E RE+ + L E ERL ++ E +E++E + + ++L
Sbjct: 195 RRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLRE-- 252
Query: 648 HSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILS 707
H E L + E + ++ + + +Q L +++ +++ +++ E++ + +
Sbjct: 253 HEER--LCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCE--QEERLRE 308
Query: 708 AYQRKCIQ-SILKEEGEHIREMVK 730
+R C Q L+E+ E + E K
Sbjct: 309 QEERLCEQEERLREQEERLCEQEK 332
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 43.9 bits (102), Expect = 5e-04
Identities = 39/168 (23%), Positives = 82/168 (48%), Gaps = 17/168 (10%)
Query: 563 QLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERL 622
QLL R + EQ +Q L +E+ +RR +LL +++++ + L +EER + +RL
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER-----LEQRL 602
Query: 623 ADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQV 682
+ E E++E R+K+ +L E++ +++ QL +Q ++
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER-----REQ 657
Query: 683 TMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVK 730
+K++ +++++E+ L + + Q + +EE E RE +K
Sbjct: 658 RLKREEEEERLEQRLKREHE-------EERREQELAEEEQEQARERIK 698
Score = 37.4 bits (85), Expect = 0.051
Identities = 46/211 (21%), Positives = 98/211 (46%), Gaps = 16/211 (7%)
Query: 530 EKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQD--LAKEEI 587
EK R +R L+ E+ + E + R Q +++ + +++ L EE
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 588 QRRVKLLCDQKKKQLEDLSYCREERKSLREMAE-RLADKYEEAKEKQEDIMNRMKKLLHS 646
++R + ++K ++ E+L +EE + LRE E R ++E K++++ ++LL
Sbjct: 979 EKRRRQEREKKYREEEELQ--QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 647 FHSELPVLSDSERDMKKELQLIPDQLRHLG--------NAIKQVTMKKDYQQQKMEKVLS 698
E L + ER ++E +L ++ + LG +++ K++ QQ+ E++L
Sbjct: 1037 -EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 699 LPKPTIILSAYQRKC--IQSILKEEGEHIRE 727
+R+C + + +EE + +RE
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLRE 1126
Score = 35.8 bits (81), Expect = 0.15
Identities = 44/229 (19%), Positives = 110/229 (48%), Gaps = 11/229 (4%)
Query: 509 REDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRA 568
RE+ ++ + ++L E EK R +R L+ E+ + E + R
Sbjct: 931 REEEQLQQEEEQLLREER---EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Query: 569 TQVFREQYILKQD---LAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADK 625
+ +RE+ L+Q+ L +EE ++R + +++ ++ ++L +EE + LRE E+ +
Sbjct: 988 KK-YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ--QEEEQLLREEREKRRLQ 1044
Query: 626 YEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK 685
E + ++E+ + + ++ L E + ER +KE +L ++ + L ++ +
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Query: 686 KDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKE--EGEHIREMVKQI 732
+ +Q + E+ L + ++ +++ Q + ++ E E +++ +Q+
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Score = 34.7 bits (78), Expect = 0.33
Identities = 41/190 (21%), Positives = 91/190 (47%), Gaps = 12/190 (6%)
Query: 509 REDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRA 568
RE+ E+ + ++L E EK R +R L+ E+ + E +L R
Sbjct: 991 REEEELQQEEEQLLREER---EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Query: 569 TQVFREQYILKQD---LAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADK 625
Q +RE+ L+Q+ L EE + R + +++ ++ E+L +EE + LRE E+ +
Sbjct: 1048 RQ-YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ--QEEEQLLREEPEKRRRQ 1104
Query: 626 YEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ---LRHLGNAIKQV 682
E + ++E+ + + ++ L E + ER ++E ++ ++ LR ++
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 683 TMKKDYQQQK 692
+++ Y++++
Sbjct: 1165 ELERQYREEE 1174
Score = 34.7 bits (78), Expect = 0.33
Identities = 26/100 (26%), Positives = 53/100 (53%), Gaps = 8/100 (8%)
Query: 572 FREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKE 631
FRE+ L+Q+ +E+++R+ + +K + E L REE++ R+ +R + E+ ++
Sbjct: 1725 FREEEQLRQETEQEQLRRQERY---RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ 1781
Query: 632 KQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ 671
++E+ R ++ F E + R ++E QL P Q
Sbjct: 1782 EREEQQLRSQESDRKFREE-----EQLRQEREEQQLRPQQ 1816
Score = 33.9 bits (76), Expect = 0.56
Identities = 35/191 (18%), Positives = 86/191 (45%), Gaps = 7/191 (3%)
Query: 548 KASEKDIAPPPEECLQLLSRATQV--FREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDL 605
K EK P+ +L Q+ Q + ++ +E+ Q+R++ ++KQ E+
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 606 SYCREERKSLREMAERLADKYEE--AKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKK 663
+EER+ +E E+ ++ E+ +E++E ++++ E + + E + ++
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 664 ELQLIPDQLRHLGNAIKQVTMKKDYQ---QQKMEKVLSLPKPTIILSAYQRKCIQSILKE 720
+ QLR ++ ++++ Q +Q++ + L + + Q + Q +
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 721 EGEHIREMVKQ 731
E +H +E +Q
Sbjct: 435 EQKHEQERREQ 445
Score = 33.9 bits (76), Expect = 0.56
Identities = 43/174 (24%), Positives = 73/174 (41%), Gaps = 20/174 (11%)
Query: 504 PLLCTREDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQ 563
PL D + E LR + E+ R L+R FLK ++ E+ Q
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQR--LRRQERERKFLKEEQQLRCQEREQ--Q 1407
Query: 564 LLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLA 623
L + FRE+ +Q L+++E R+ + Q ++Q ERK L E +
Sbjct: 1408 LRQDRDRKFREE---EQQLSRQERDRKFREEEQQVRRQ-------ERERKFLEEEQQLRQ 1457
Query: 624 DKYEEAKEKQEDIMNRMKKLLH------SFHSELPVLSDSERDMKKELQLIPDQ 671
+++ + +E+++ + R ++ LH F E L ERD K Q + Q
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Score = 32.7 bits (73), Expect = 1.2
Identities = 41/200 (20%), Positives = 89/200 (44%), Gaps = 18/200 (9%)
Query: 546 FLKASEKDIAPPPEECLQLLSRATQVFREQYILK--QDLAKEEIQRRVKLLCDQKKKQLE 603
+LK E+ E Q L R + R + LK ++ +E+ +RR + L +++++ E
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Query: 604 DLSYCREERKSLREMAERLADKYEEAKEKQEDIMNR-MKKLLHSFHSELPVLSDSE---- 658
+EE + L++ E +E++E ++ R +K L E + + E
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Query: 659 -----RDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKP------TIILS 707
+ +++ +L +Q L +K+ +++ Q+++ E+ L +P ++ S
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 708 AYQRKCIQSILKEEGEHIRE 727
Q + Q L+ E + RE
Sbjct: 637 EEQEERRQQQLRREQQERRE 656
Score = 32.7 bits (73), Expect = 1.2
Identities = 34/151 (22%), Positives = 67/151 (44%), Gaps = 18/151 (11%)
Query: 563 QLLSRATQVFREQYILKQDLAKEEIQRRVKLLC---DQKKKQLEDLSYCREERKS----- 614
QLL + R Q + +Q +EE+Q+ + L +K+++ E CREE +
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 615 --LREMAER-----LADKY---EEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKE 664
LRE E+ L +Y EE ++++E ++ + E + E ++E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 665 LQLIPDQLRHLGNAIKQVTMKKDYQQQKMEK 695
L +Q + +Q +++ Q+QK ++
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Score = 31.6 bits (70), Expect = 2.8
Identities = 38/169 (22%), Positives = 72/169 (42%), Gaps = 28/169 (16%)
Query: 563 QLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERL 622
Q L R Q+ REQ + ++ + E Q R +++QL R E++ RE E
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLR-------REQQLRREQQLRREQQLRREQEE-- 431
Query: 623 ADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQV 682
+ E K +QE R+K+ + + + L+ + RH KQ
Sbjct: 432 --ERHEQKHEQERREQRLKR--------------EQEERRDWLKREEETERHEQERRKQ- 474
Query: 683 TMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQ 731
+K+D ++++ E+ L L + Q + Q + +E+ E + +K+
Sbjct: 475 QLKRDQEEERRERWLKLEEEE--RREQQERREQQLRREQEERREQRLKR 521
Score = 31.6 bits (70), Expect = 2.8
Identities = 35/162 (21%), Positives = 75/162 (46%), Gaps = 10/162 (6%)
Query: 509 REDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRA 568
RE+ E+ + ++L E E R L+R L+ E+ + E + R
Sbjct: 1051 REEEELQQEEEQLLGEER---ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 569 TQVFREQYILKQD--LAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAE-RLADK 625
Q E+ + +++ L +EE ++R + +++ ++ E++ +EE + LRE E R +
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ--QEEEQLLREEPEKRRRQE 1165
Query: 626 YEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQL 667
E ++E++ ++LL + + ER ++E +L
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKR--RQERERQYREEEEL 1205
Score = 31.2 bits (69), Expect = 3.6
Identities = 29/144 (20%), Positives = 62/144 (43%), Gaps = 14/144 (9%)
Query: 568 ATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREER--------------K 613
A +EQ +Q L +EE + + +++++Q ++ Y EE+ K
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950
Query: 614 SLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLR 673
R+ ER K ++ ++K+E ++ + E + E ++E L ++ +
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 674 HLGNAIKQVTMKKDYQQQKMEKVL 697
++ KKD QQ+ E++L
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLL 1034
Score = 30.0 bits (66), Expect = 8.1
Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 12/104 (11%)
Query: 556 PPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSL 615
P E QLL Q R Q Q L +E+ +RR + L +++++ + RE +
Sbjct: 625 PEEERRQQLLKSEEQEERRQ----QQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 616 REMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSER 659
RE E A+E+QE R+K + + +L +D+ +
Sbjct: 681 REQ--------ELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 43.1 bits (100), Expect = 0.001
Identities = 54/252 (21%), Positives = 105/252 (41%), Gaps = 46/252 (18%)
Query: 509 REDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRA 568
+ ++E L E S + +++Q+S + ++ EK I+ ++ Q
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQ----- 1020
Query: 569 TQVFREQYILKQDL-----AKEEIQRRVKLLCDQKKKQLEDL-----SYCREERKSLREM 618
E+ IL Q A E++ ++ K +K +LE L S C + L ++
Sbjct: 1021 -----EKLILLQRCEETGNAYEDLSQKYKA-AQEKNSKLECLLNECTSLCENRKNELEQL 1074
Query: 619 AERLADKYEE-------AKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ 671
E A +++E A+E+ +++M ++ + + SE+ +D++ + K E
Sbjct: 1075 KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM---TDNQNNSKSE------- 1124
Query: 672 LRHLGNAIKQVTMKKDYQQQKMEKVLS--LPKPTIILSAYQRKCIQSILKEEGEHIREMV 729
+KQ M +Q KM+K ++ L + ++ + K E E IR V
Sbjct: 1125 ----AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK--HECQNLESEPIRNSV 1178
Query: 730 KQINDIRNHVNF 741
K+ RN NF
Sbjct: 1179 KERESERNQCNF 1190
Score = 38.1 bits (87), Expect = 0.030
Identities = 55/242 (22%), Positives = 106/242 (43%), Gaps = 38/242 (15%)
Query: 505 LLCTREDVEVAESPL-RVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQ 563
L C R++ E A L + + E F++ L ++ +EC+Q
Sbjct: 371 LSCQRQNAESARCSLEQKIKEKEKEFQEE--------------LSRQQRSFQTLDQECIQ 416
Query: 564 LLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLA 623
+ +R TQ ++ + ++ + E+ + + K+QLE+ +++ E A + +
Sbjct: 417 MKARLTQELQQAKNM-HNVLQAELDKLTSV-----KQQLENNLEEFKQKLCRAEQAFQAS 470
Query: 624 DKYEEAKEKQEDIMNRMKKLLHSFHSELPV--LSDSERDMKKELQLIPDQLRHLGNAIK- 680
E + + M + LL S HSE + E ++K Q + +Q ++ +K
Sbjct: 471 QIKENELRRSMEEMKKENNLLKS-HSEQKAREVCHLEAELKNIKQCL-NQSQNFAEEMKA 528
Query: 681 ----QVTMKKDYQQQ--KMEKVLSLPKPTIILSAY--QRKCIQSILKEEGEHIREMVKQI 732
Q TM +D Q++ + E L+L K + ++ QR C Q +LK+ HI +Q+
Sbjct: 529 KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHI----EQL 584
Query: 733 ND 734
ND
Sbjct: 585 ND 586
Score = 36.2 bits (82), Expect = 0.11
Identities = 54/229 (23%), Positives = 99/229 (43%), Gaps = 34/229 (14%)
Query: 519 LRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYIL 578
LRV E + + HI L+ + E D E L+ + ++ +E IL
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKE--------RERENDSLKDKVENLERELQMSEENQELVIL 2175
Query: 579 KQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMN 638
+ +K E++ L Q ++ L + +LR E L + +E + + ++
Sbjct: 2176 DAENSKAEVET----LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ----LS 2227
Query: 639 RMKKLLHSFHSELPVLSDSERDMKKE----LQLIPDQLRHLGNAI-----KQVTMKKDYQ 689
+ KLL SF S L +E +K+E ++++ +QL+ L A+ Q MK Q
Sbjct: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2287
Query: 690 ------QQKMEKVLSLPKPTIILSAYQRK--CIQSILKEEGEHIREMVK 730
+++ + S+ K L A ++K C+ LK E EH +++K
Sbjct: 2288 SLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK-ESEHHADLLK 2335
Score = 35.4 bits (80), Expect = 0.19
Identities = 44/242 (18%), Positives = 106/242 (43%), Gaps = 21/242 (8%)
Query: 512 VEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQV 571
++VAE+ ++ E + + +L+ L++ EKD +L ++ Q+
Sbjct: 2002 IQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQL 2061
Query: 572 FREQYIL------------KQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMA 619
+E+ +L + D K + + ++ +K + LS +EE LR
Sbjct: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI 2121
Query: 620 ERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ----LRHL 675
E+L + E ++KQ I ++K+ E L D ++++ELQ+ + +
Sbjct: 2122 EKLRVRIEADEKKQLHIAEKLKER----ERENDSLKDKVENLERELQMSEENQELVILDA 2177
Query: 676 GNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQINDI 735
N+ +V K Q ++M + L + + ++ +++ + ++E+ + E+ K ++
Sbjct: 2178 ENSKAEVETLKT-QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
Query: 736 RN 737
++
Sbjct: 2237 KS 2238
Score = 34.3 bits (77), Expect = 0.43
Identities = 44/195 (22%), Positives = 80/195 (41%), Gaps = 33/195 (16%)
Query: 513 EVAESPLRV----------LAETPDSFEKHIRSILQRSVANPAFLKASEKDI---APPPE 559
E+AE LR+ L +T +E I++ ++ + L + + +I E
Sbjct: 2695 EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKE 2754
Query: 560 ECLQLLSRATQVFREQYILKQDLAK---------EEIQRRVKLL---CDQ-------KKK 600
E L TQ+ E K D K E Q ++KLL C Q +K
Sbjct: 2755 ELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQK 2814
Query: 601 QLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERD 660
+L L +E++K+ M ++ + E KE +E + + K+ +L E+
Sbjct: 2815 ELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEK- 2873
Query: 661 MKKELQLIPDQLRHL 675
++K +++ Q+ HL
Sbjct: 2874 LEKAKEMLETQVAHL 2888
Score = 33.1 bits (74), Expect = 0.96
Identities = 47/232 (20%), Positives = 103/232 (44%), Gaps = 18/232 (7%)
Query: 516 ESPLRVLAETPDSFEKHIRSILQRSVAN-PAFLKASEKDIAPPPEECLQLLSRATQVFRE 574
E ++VL S + + +LQ S N L+ ++ D E+ ++ ++ T++ RE
Sbjct: 2566 EQKIQVLQSKNASLQDTLE-VLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQRE 2624
Query: 575 QYILKQDLAK--EEIQRRVKLLCDQKKKQLEDLSYCREERKSLR----EMAERLADKYEE 628
+ + Q A+ EE+ L + + LE++ +++ K L E+ + L +++
Sbjct: 2625 MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD 2684
Query: 629 AKEKQ----EDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTM 684
EK+ E+I +L + +L D+ + + E+Q ++L + +
Sbjct: 2685 QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL 2744
Query: 685 KKDYQQQKMEKV-LSLPKPTIILSAYQRKCIQSI-----LKEEGEHIREMVK 730
+ D + E++ SL T IL ++ + ++ LK+E E + +K
Sbjct: 2745 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
Score = 32.7 bits (73), Expect = 1.2
Identities = 37/190 (19%), Positives = 84/190 (44%), Gaps = 29/190 (15%)
Query: 560 ECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQL-----EDLSYCREERKS 614
E ++ S + E L+ DL + ++ ++ K+++ E+LS ER
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ 1962
Query: 615 LREMAERLADKY-------EEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQL 667
LR + ++ K E+ KEK +++ + + LH + +E ++K++ +L
Sbjct: 1963 LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH-------CIQVAEAEVKEKTEL 2015
Query: 668 IPDQLRHLGNAIKQVTMKKDYQQQKME------KVLSLPKPTIILSAYQRKCIQSILKEE 721
L+ L + + ++ K + Q+K++ + LSL K + Q + +L +E
Sbjct: 2016 ----LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKE 2071
Query: 722 GEHIREMVKQ 731
E ++ + +
Sbjct: 2072 SESLQARLSE 2081
Score = 32.0 bits (71), Expect = 2.1
Identities = 25/164 (15%), Positives = 70/164 (42%), Gaps = 3/164 (1%)
Query: 580 QDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNR 639
Q ++Q++ + L K + E+L + +S + K +E ++++
Sbjct: 842 QKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAE 901
Query: 640 MKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKD---YQQQKMEKV 696
L + EL +L+D + E+Q + L +++K++ + + ++++M +
Sbjct: 902 TLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI 961
Query: 697 LSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQINDIRNHVN 740
+SL K I + ++ I + ++++ N+++
Sbjct: 962 ISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID 1005
Score = 30.8 bits (68), Expect = 4.7
Identities = 35/152 (23%), Positives = 72/152 (47%), Gaps = 14/152 (9%)
Query: 585 EEIQRRVKLLC-DQK--KKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMK 641
+E+ V LC DQ+ K + L EE LR E+L + E ++KQ ++ ++K
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325
Query: 642 KLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQK-----MEKV 696
+ H H++L L ++++EL++ H A++ K + + K M +
Sbjct: 2326 ESEH--HADL--LKGRVENLERELEIARTNQEHA--ALEAENSKGEVETLKAKIEGMTQS 2379
Query: 697 LSLPKPTIILSAYQRKCIQSILKEEGEHIREM 728
L + ++ +++ + + L++E E I E+
Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERISEL 2411
>gi|41352705 kinesin family member 3C [Homo sapiens]
Length = 793
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/151 (23%), Positives = 69/151 (45%), Gaps = 14/151 (9%)
Query: 557 PPEECLQLLSRATQVFREQYILKQDLAKEE----IQRRVKLLCDQKKKQLEDLSYCREER 612
PP+ +L A + E Y+ +Q EE IQ L+ ++K+K LE+ E+
Sbjct: 444 PPQP---ILESALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDL 500
Query: 613 KSLREMAERLADKYEEAKEKQ-------EDIMNRMKKLLHSFHSELPVLSDSERDMKKEL 665
+ ++ E LA KY+ + K D N +K+L E+ ER+M++E+
Sbjct: 501 RREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEM 560
Query: 666 QLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
L ++ L + + + + +K++K+
Sbjct: 561 MLRDEETMELRGTYTSLQQEVEVKTKKLKKL 591
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/179 (23%), Positives = 85/179 (47%), Gaps = 13/179 (7%)
Query: 533 IRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVF-REQYILKQDLAKEE---IQ 588
+ S L + + ++ K+IA E + L ++ + +E++ L+ + KE +
Sbjct: 531 LESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALS 590
Query: 589 RRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKL----- 643
R+ D + LE L++ E KSL++ + +K + +E+ RMKKL
Sbjct: 591 RKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR 650
Query: 644 -LHSFH--SELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSL 699
L FH SEL V + ++ + Q++ Q +H N +K + K++ ++ E++ +L
Sbjct: 651 KLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH-QNDLKMLAAKEEQLREFQEEMAAL 708
Score = 37.4 bits (85), Expect = 0.051
Identities = 35/196 (17%), Positives = 84/196 (42%), Gaps = 10/196 (5%)
Query: 538 QRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKE---EIQRRVKLL 594
QR + L + D + LQ+L + + + ++ + +E E+ ++ L
Sbjct: 359 QRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKL 418
Query: 595 --CDQKKKQLEDLSYCREERKSLREMAERLADKYEEA---KEKQEDIMNRMKKLLHSFHS 649
D++K+QL+ E+ + +M +R+ ++ E K K E+ + KLL
Sbjct: 419 ENSDKEKRQLQKT--VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 476
Query: 650 ELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAY 709
+L + E+ M+ EL+ + + + +K+ + K + + + + L + S
Sbjct: 477 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 536
Query: 710 QRKCIQSILKEEGEHI 725
+ Q ++++ + I
Sbjct: 537 KYNTSQQVIQDLNKEI 552
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/179 (23%), Positives = 85/179 (47%), Gaps = 13/179 (7%)
Query: 533 IRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVF-REQYILKQDLAKEE---IQ 588
+ S L + + ++ K+IA E + L ++ + +E++ L+ + KE +
Sbjct: 676 LESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALS 735
Query: 589 RRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKL----- 643
R+ D + LE L++ E KSL++ + +K + +E+ RMKKL
Sbjct: 736 RKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR 795
Query: 644 -LHSFH--SELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSL 699
L FH SEL V + ++ + Q++ Q +H N +K + K++ ++ E++ +L
Sbjct: 796 KLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH-QNDLKMLAAKEEQLREFQEEMAAL 853
Score = 37.4 bits (85), Expect = 0.051
Identities = 35/196 (17%), Positives = 84/196 (42%), Gaps = 10/196 (5%)
Query: 538 QRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKE---EIQRRVKLL 594
QR + L + D + LQ+L + + + ++ + +E E+ ++ L
Sbjct: 504 QRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKL 563
Query: 595 --CDQKKKQLEDLSYCREERKSLREMAERLADKYEEA---KEKQEDIMNRMKKLLHSFHS 649
D++K+QL+ E+ + +M +R+ ++ E K K E+ + KLL
Sbjct: 564 ENSDKEKRQLQKT--VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 621
Query: 650 ELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAY 709
+L + E+ M+ EL+ + + + +K+ + K + + + + L + S
Sbjct: 622 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
Query: 710 QRKCIQSILKEEGEHI 725
+ Q ++++ + I
Sbjct: 682 KYNTSQQVIQDLNKEI 697
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/171 (22%), Positives = 81/171 (47%), Gaps = 21/171 (12%)
Query: 579 KQDLAKEEIQRRVKLLCDQKKKQLEDLSYCRE----ERKSLREMAERLADKYEEAKEKQE 634
KQDL K+ RV+L +LE++ C E E+ L E L + E +++Q
Sbjct: 358 KQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQL 417
Query: 635 DIMNRMKKLLHSF--------HSELPV--LSDSERDMKKELQLIPDQLRHLGNAIKQVTM 684
+++R+K++ + F H++L + L+ D K+ + R+L + ++Q
Sbjct: 418 QMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAE------RYL-SELQQSEA 470
Query: 685 KKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQINDI 735
K+ +++ E + + +I + K ++ L+++ E + E+ + N I
Sbjct: 471 LKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQI 521
Score = 32.7 bits (73), Expect = 1.2
Identities = 34/144 (23%), Positives = 63/144 (43%), Gaps = 5/144 (3%)
Query: 596 DQKKKQL-EDLSYCREERKSLREMAERLADKYEEAKEKQE---DIMNRMKKLLHSFHSEL 651
D+ K QL L RK L ++ + A + EE K+E DI + L + L
Sbjct: 526 DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585
Query: 652 PVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQR 711
+ E ++KK+ ++ + +++ K Q Q K+L + + LSA R
Sbjct: 586 DTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAI-R 644
Query: 712 KCIQSILKEEGEHIREMVKQINDI 735
+ + L EE + ++K ++D+
Sbjct: 645 ADLANKLAEEERAKKAVLKDLSDL 668
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/193 (24%), Positives = 82/193 (42%), Gaps = 18/193 (9%)
Query: 494 LLSTVHPASPPLLCTREDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKD 553
LL S L +D + A+ + L E E+ I S + A A L+ +
Sbjct: 509 LLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKAT 568
Query: 554 IAPPPEECLQL---LSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQ-------LE 603
+A E +L L Q E Y + K +IQ ++ + K+K E
Sbjct: 569 VASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQE 628
Query: 604 DLSYCREERKSLREMAERLADKY----EEAKEKQEDIMNRMKKLLHSFHSELPVLSDSER 659
DL++ R + L++ ++ D+Y EEAK++ ED+ ++KL S+L
Sbjct: 629 DLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKL----RSDLDEKETERS 684
Query: 660 DMKKELQLIPDQL 672
DMK+ + + D++
Sbjct: 685 DMKETIFELEDEV 697
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/193 (24%), Positives = 82/193 (42%), Gaps = 18/193 (9%)
Query: 494 LLSTVHPASPPLLCTREDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKD 553
LL S L +D + A+ + L E E+ I S + A A L+ +
Sbjct: 509 LLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKAT 568
Query: 554 IAPPPEECLQL---LSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQ-------LE 603
+A E +L L Q E Y + K +IQ ++ + K+K E
Sbjct: 569 VASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQE 628
Query: 604 DLSYCREERKSLREMAERLADKY----EEAKEKQEDIMNRMKKLLHSFHSELPVLSDSER 659
DL++ R + L++ ++ D+Y EEAK++ ED+ ++KL S+L
Sbjct: 629 DLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKL----RSDLDEKETERS 684
Query: 660 DMKKELQLIPDQL 672
DMK+ + + D++
Sbjct: 685 DMKETIFELEDEV 697
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/141 (23%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 596 DQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLS 655
+Q K+Q S CR+E LR + L ++ E ++E ++K+ + +EL
Sbjct: 209 EQWKRQF---SICRDENDRLRNKIDELEEQCSEINREKEK-NTQLKRRIEELEAELREKE 264
Query: 656 DSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQ 715
+D++K+ ++IP + +++ + Q +KV SL K I S Y+++ ++
Sbjct: 265 TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL-KTDIEESKYRQRHLK 323
Query: 716 SILKEEGEHIREMVKQINDIR 736
LK E + + ++D R
Sbjct: 324 VELKSFLEVLDGKIDDLHDFR 344
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/141 (23%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 596 DQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLS 655
+Q K+Q S CR+E LR + L ++ E ++E ++K+ + +EL
Sbjct: 198 EQWKRQF---SICRDENDRLRNKIDELEEQCSEINREKEK-NTQLKRRIEELEAELREKE 253
Query: 656 DSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQ 715
+D++K+ ++IP + +++ + Q +KV SL K I S Y+++ ++
Sbjct: 254 TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL-KTDIEESKYRQRHLK 312
Query: 716 SILKEEGEHIREMVKQINDIR 736
LK E + + ++D R
Sbjct: 313 VELKSFLEVLDGKIDDLHDFR 333
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 41.2 bits (95), Expect = 0.004
Identities = 48/192 (25%), Positives = 85/192 (44%), Gaps = 17/192 (8%)
Query: 563 QLLSRATQVFREQYILKQDLAKEEIQRRV----KLLCDQKKKQLEDL--------SYCRE 610
QL + ++ ++ L++ L +EE R+ K+ + K K+LED + +
Sbjct: 940 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 611 ERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPD 670
ERK L E L E +EK ++ + ++K S SEL V E ++EL+ +
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 671 QLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEG--EHIREM 728
+L G+A D Q Q E + L K L A + I ++ + IRE+
Sbjct: 1059 KLE--GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116
Query: 729 VKQINDIRNHVN 740
I+D++ ++
Sbjct: 1117 EGHISDLQEDLD 1128
Score = 38.5 bits (88), Expect = 0.023
Identities = 38/141 (26%), Positives = 67/141 (47%), Gaps = 20/141 (14%)
Query: 580 QDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNR 639
Q+L +EE R KL K +QLE EER SL++ D+ EAK+ E ++
Sbjct: 1321 QELLQEET--RQKLNVSTKLRQLE------EERNSLQDQL----DEEMEAKQNLERHIST 1368
Query: 640 M-------KKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQK 692
+ KK L F S + L + ++ +KE++ + Q A ++ K+ QQ+
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 693 MEK-VLSLPKPTIILSAYQRK 712
++ V+ L ++S ++K
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKK 1449
Score = 32.7 bits (73), Expect = 1.2
Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 8/100 (8%)
Query: 586 EIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLH 645
E Q K L + KK E L +ERK +A++Y+E EK + ++K+ L
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERK--------MAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 646 SFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK 685
E ++ + R +++EL + +G + + K
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 31.6 bits (70), Expect = 2.8
Identities = 35/173 (20%), Positives = 73/173 (42%), Gaps = 17/173 (9%)
Query: 517 SPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEK----------DIAPPPEECLQLLS 566
S + L E F+K I ++ Q+ A EK D+ + QL+S
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 567 ---RATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLA 623
+ + F + +++++ + R + + ++K+ + LS R ++L E E L
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1503
Query: 624 DKYEEAKEKQEDIMNR---MKKLLHSFHSELPVLSDSERDMKKELQLIPDQLR 673
+ K + ED+++ + K +H L +MK +L+ + D+L+
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Score = 31.2 bits (69), Expect = 3.6
Identities = 25/112 (22%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 585 EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLL 644
+E++++ L ++K E L E EM RLA K K++ E+I++ M+ L
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK----KQELEEILHEMEARL 931
Query: 645 HSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
L + M +++ + +QL A +++ ++K + K++K+
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983
Score = 30.8 bits (68), Expect = 4.7
Identities = 19/87 (21%), Positives = 43/87 (49%)
Query: 612 RKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ 671
+K+L E + +E ++K + + + L F L +++ ++KE + +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 672 LRHLGNAIKQVTMKKDYQQQKMEKVLS 698
LR LG A ++V KK + +++++ S
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQS 1266
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 41.2 bits (95), Expect = 0.004
Identities = 48/192 (25%), Positives = 85/192 (44%), Gaps = 17/192 (8%)
Query: 563 QLLSRATQVFREQYILKQDLAKEEIQRRV----KLLCDQKKKQLEDL--------SYCRE 610
QL + ++ ++ L++ L +EE R+ K+ + K K+LED + +
Sbjct: 947 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 611 ERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPD 670
ERK L E L E +EK ++ + ++K S SEL V E ++EL+ +
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 671 QLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEG--EHIREM 728
+L G+A D Q Q E + L K L A + I ++ + IRE+
Sbjct: 1066 KLE--GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123
Query: 729 VKQINDIRNHVN 740
I+D++ ++
Sbjct: 1124 EGHISDLQEDLD 1135
Score = 38.5 bits (88), Expect = 0.023
Identities = 38/141 (26%), Positives = 67/141 (47%), Gaps = 20/141 (14%)
Query: 580 QDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNR 639
Q+L +EE R KL K +QLE EER SL++ D+ EAK+ E ++
Sbjct: 1328 QELLQEET--RQKLNVSTKLRQLE------EERNSLQDQL----DEEMEAKQNLERHIST 1375
Query: 640 M-------KKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQK 692
+ KK L F S + L + ++ +KE++ + Q A ++ K+ QQ+
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 693 MEK-VLSLPKPTIILSAYQRK 712
++ V+ L ++S ++K
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKK 1456
Score = 32.7 bits (73), Expect = 1.2
Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 8/100 (8%)
Query: 586 EIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLH 645
E Q K L + KK E L +ERK +A++Y+E EK + ++K+ L
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERK--------MAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 646 SFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK 685
E ++ + R +++EL + +G + + K
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 31.6 bits (70), Expect = 2.8
Identities = 35/173 (20%), Positives = 73/173 (42%), Gaps = 17/173 (9%)
Query: 517 SPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEK----------DIAPPPEECLQLLS 566
S + L E F+K I ++ Q+ A EK D+ + QL+S
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 567 ---RATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLA 623
+ + F + +++++ + R + + ++K+ + LS R ++L E E L
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1510
Query: 624 DKYEEAKEKQEDIMNR---MKKLLHSFHSELPVLSDSERDMKKELQLIPDQLR 673
+ K + ED+++ + K +H L +MK +L+ + D+L+
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Score = 31.2 bits (69), Expect = 3.6
Identities = 25/112 (22%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 585 EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLL 644
+E++++ L ++K E L E EM RLA K K++ E+I++ M+ L
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK----KQELEEILHEMEARL 938
Query: 645 HSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
L + M +++ + +QL A +++ ++K + K++K+
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Score = 30.8 bits (68), Expect = 4.7
Identities = 19/87 (21%), Positives = 43/87 (49%)
Query: 612 RKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ 671
+K+L E + +E ++K + + + L F L +++ ++KE + +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 672 LRHLGNAIKQVTMKKDYQQQKMEKVLS 698
LR LG A ++V KK + +++++ S
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQS 1273
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 41.2 bits (95), Expect = 0.004
Identities = 48/192 (25%), Positives = 85/192 (44%), Gaps = 17/192 (8%)
Query: 563 QLLSRATQVFREQYILKQDLAKEEIQRRV----KLLCDQKKKQLEDL--------SYCRE 610
QL + ++ ++ L++ L +EE R+ K+ + K K+LED + +
Sbjct: 947 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006
Query: 611 ERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPD 670
ERK L E L E +EK ++ + ++K S SEL V E ++EL+ +
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 671 QLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEG--EHIREM 728
+L G+A D Q Q E + L K L A + I ++ + IRE+
Sbjct: 1066 KLE--GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123
Query: 729 VKQINDIRNHVN 740
I+D++ ++
Sbjct: 1124 EGHISDLQEDLD 1135
Score = 38.5 bits (88), Expect = 0.023
Identities = 38/141 (26%), Positives = 67/141 (47%), Gaps = 20/141 (14%)
Query: 580 QDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNR 639
Q+L +EE R KL K +QLE EER SL++ D+ EAK+ E ++
Sbjct: 1328 QELLQEET--RQKLNVSTKLRQLE------EERNSLQDQL----DEEMEAKQNLERHIST 1375
Query: 640 M-------KKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQK 692
+ KK L F S + L + ++ +KE++ + Q A ++ K+ QQ+
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 693 MEK-VLSLPKPTIILSAYQRK 712
++ V+ L ++S ++K
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKK 1456
Score = 32.7 bits (73), Expect = 1.2
Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 8/100 (8%)
Query: 586 EIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLH 645
E Q K L + KK E L +ERK +A++Y+E EK + ++K+ L
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERK--------MAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 646 SFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK 685
E ++ + R +++EL + +G + + K
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 31.6 bits (70), Expect = 2.8
Identities = 35/173 (20%), Positives = 73/173 (42%), Gaps = 17/173 (9%)
Query: 517 SPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEK----------DIAPPPEECLQLLS 566
S + L E F+K I ++ Q+ A EK D+ + QL+S
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 567 ---RATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLA 623
+ + F + +++++ + R + + ++K+ + LS R ++L E E L
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1510
Query: 624 DKYEEAKEKQEDIMNR---MKKLLHSFHSELPVLSDSERDMKKELQLIPDQLR 673
+ K + ED+++ + K +H L +MK +L+ + D+L+
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Score = 31.2 bits (69), Expect = 3.6
Identities = 25/112 (22%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 585 EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLL 644
+E++++ L ++K E L E EM RLA K K++ E+I++ M+ L
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK----KQELEEILHEMEARL 938
Query: 645 HSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
L + M +++ + +QL A +++ ++K + K++K+
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Score = 30.8 bits (68), Expect = 4.7
Identities = 19/87 (21%), Positives = 43/87 (49%)
Query: 612 RKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ 671
+K+L E + +E ++K + + + L F L +++ ++KE + +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 672 LRHLGNAIKQVTMKKDYQQQKMEKVLS 698
LR LG A ++V KK + +++++ S
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQS 1273
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 41.2 bits (95), Expect = 0.004
Identities = 48/192 (25%), Positives = 85/192 (44%), Gaps = 17/192 (8%)
Query: 563 QLLSRATQVFREQYILKQDLAKEEIQRRV----KLLCDQKKKQLEDL--------SYCRE 610
QL + ++ ++ L++ L +EE R+ K+ + K K+LED + +
Sbjct: 940 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 611 ERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPD 670
ERK L E L E +EK ++ + ++K S SEL V E ++EL+ +
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 671 QLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEG--EHIREM 728
+L G+A D Q Q E + L K L A + I ++ + IRE+
Sbjct: 1059 KLE--GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116
Query: 729 VKQINDIRNHVN 740
I+D++ ++
Sbjct: 1117 EGHISDLQEDLD 1128
Score = 38.5 bits (88), Expect = 0.023
Identities = 38/141 (26%), Positives = 67/141 (47%), Gaps = 20/141 (14%)
Query: 580 QDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNR 639
Q+L +EE R KL K +QLE EER SL++ D+ EAK+ E ++
Sbjct: 1321 QELLQEET--RQKLNVSTKLRQLE------EERNSLQDQL----DEEMEAKQNLERHIST 1368
Query: 640 M-------KKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQK 692
+ KK L F S + L + ++ +KE++ + Q A ++ K+ QQ+
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 693 MEK-VLSLPKPTIILSAYQRK 712
++ V+ L ++S ++K
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKK 1449
Score = 32.7 bits (73), Expect = 1.2
Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 8/100 (8%)
Query: 586 EIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLH 645
E Q K L + KK E L +ERK +A++Y+E EK + ++K+ L
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERK--------MAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 646 SFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK 685
E ++ + R +++EL + +G + + K
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 31.6 bits (70), Expect = 2.8
Identities = 35/173 (20%), Positives = 73/173 (42%), Gaps = 17/173 (9%)
Query: 517 SPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEK----------DIAPPPEECLQLLS 566
S + L E F+K I ++ Q+ A EK D+ + QL+S
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 567 ---RATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLA 623
+ + F + +++++ + R + + ++K+ + LS R ++L E E L
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1503
Query: 624 DKYEEAKEKQEDIMNR---MKKLLHSFHSELPVLSDSERDMKKELQLIPDQLR 673
+ K + ED+++ + K +H L +MK +L+ + D+L+
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Score = 31.2 bits (69), Expect = 3.6
Identities = 25/112 (22%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 585 EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLL 644
+E++++ L ++K E L E EM RLA K K++ E+I++ M+ L
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK----KQELEEILHEMEARL 931
Query: 645 HSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
L + M +++ + +QL A +++ ++K + K++K+
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 983
Score = 30.8 bits (68), Expect = 4.7
Identities = 19/87 (21%), Positives = 43/87 (49%)
Query: 612 RKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQ 671
+K+L E + +E ++K + + + L F L +++ ++KE + +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 672 LRHLGNAIKQVTMKKDYQQQKMEKVLS 698
LR LG A ++V KK + +++++ S
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQS 1266
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 40.8 bits (94), Expect = 0.005
Identities = 43/197 (21%), Positives = 97/197 (49%), Gaps = 25/197 (12%)
Query: 547 LKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKK------K 600
L+ EK I E+ + R + REQ ++ +E++ R+ K L +Q+K K
Sbjct: 281 LREQEKKIRKQEEK----MWRQEERLREQEGKMRE-QEEKMWRQEKRLREQEKELREQEK 335
Query: 601 QLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERD 660
+L + RE+ + ++E E++ ++ E+ +E++E + + ++L + E+
Sbjct: 336 ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW-----------EQEKQ 384
Query: 661 MKKELQLIPDQLRHLGNAIKQVTMKKD--YQQQKM-EKVLSLPKPTIILSAYQRKCIQSI 717
M+++ Q + DQ + +++ K++ +Q+KM E+V + + + ++ Q
Sbjct: 385 MREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE 444
Query: 718 LKEEGEHIREMVKQIND 734
+E E IRE K++ +
Sbjct: 445 KMQEEERIREREKKMRE 461
Score = 40.4 bits (93), Expect = 0.006
Identities = 34/156 (21%), Positives = 72/156 (46%), Gaps = 7/156 (4%)
Query: 579 KQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMN 638
K+ +EE R + + +++KK E+ RE+ + ++E E++ ++ E+ E++E +
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Query: 639 RMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLS 698
+ +K+ + E + E+ E Q +P+Q L K +K Q++ EK+
Sbjct: 636 QEEKM---WEQEEKMWEQEEK--MWEQQRLPEQKEKLWEHEKMQEQEK--MQEQEEKIWE 688
Query: 699 LPKPTIILSAYQRKCIQSILKEEGEHIREMVKQIND 734
K ++K E E +RE K++ +
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE 724
Score = 38.9 bits (89), Expect = 0.017
Identities = 27/125 (21%), Positives = 62/125 (49%), Gaps = 17/125 (13%)
Query: 573 REQYILKQDLAKEEIQRRVKLLCDQKKKQLEDL-----SYCREERKSLREMAERLADKYE 627
+E+ I +Q+ +++ Q + K DQ+K + E+ REE + +RE E++ ++ E
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 628 EAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKD 687
+ +E++E++ + +K+ + + E Q +P+Q L K +K
Sbjct: 742 KMQEQEEEMWEQEEKMW------------EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
Query: 688 YQQQK 692
++Q++
Sbjct: 790 WEQEE 794
Score = 35.4 bits (80), Expect = 0.19
Identities = 25/112 (22%), Positives = 59/112 (52%), Gaps = 4/112 (3%)
Query: 584 KEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKL 643
+E++ R+ + L +Q+K+ E R++ + + E ERL +K EE +QE + +++K+
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMWEQVEKM 426
Query: 644 LHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEK 695
++ RD ++++Q +++R +++ Q++KM+K
Sbjct: 427 RE--EKKMQEQEKKTRDQEEKMQ-EEERIREREKKMREEEETMREQEEKMQK 475
Score = 30.8 bits (68), Expect = 4.7
Identities = 18/88 (20%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 584 KEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKL 643
+EE++ + K + Q++K RE+ +RE E++ + + +E+++++ + K+L
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
Query: 644 LHSFHSELPVLSDSERDMKKELQLIPDQ 671
E L + E M+++ + + +Q
Sbjct: 338 -----REQKELREQEEQMQEQEEKMWEQ 360
Score = 30.0 bits (66), Expect = 8.1
Identities = 34/128 (26%), Positives = 66/128 (51%), Gaps = 20/128 (15%)
Query: 573 REQYILKQ---DLAKEEIQRRVKLLCDQKKK--QLEDLSYCREERKSLREMAERLADKYE 627
R +++L Q + +EE+ R+ + L +Q+KK + E+ + +EER LRE ++
Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER--LREQEGKM----- 309
Query: 628 EAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMK--KELQLIPDQLRHLGNAIKQVTMK 685
+QE+ M R +K L E L + E++++ KEL+ +Q++ + + K
Sbjct: 310 ---REQEEKMWRQEKRLREQEKE---LREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363
Query: 686 KDYQQQKM 693
Q++KM
Sbjct: 364 MREQEEKM 371
>gi|112734867 retinitis pigmentosa GTPase regulator interacting
protein 1 [Homo sapiens]
Length = 1286
Score = 40.8 bits (94), Expect = 0.005
Identities = 56/228 (24%), Positives = 96/228 (42%), Gaps = 32/228 (14%)
Query: 509 REDVEVAESPLRVLAETPDSFEK-HIRSILQRSVANPAFLKASEKDIAPPPEECLQ---- 563
R +E A+ + A + E ++ +L A+ KA ++ E LQ
Sbjct: 254 RSSLECAQKAAELRASIKEKVELIRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQG 313
Query: 564 LLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLA 623
+LS A + +Q + KEE ++ V L K QLED+S + +L+E ER+
Sbjct: 314 ILSAAHEALLKQVNELRAELKEESKKAVSL-----KSQLEDVSIL---QMTLKEFQERVE 365
Query: 624 DKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVT 683
D +E K ++ ++ +L S SDS +LI +QL+ +QV+
Sbjct: 366 DLEKERKLLNDNYDKLLESMLDS--------SDSSSQPHWSNELIAEQLQ------QQVS 411
Query: 684 MKKDYQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEEGEHIREMVKQ 731
+D ++E K ++L + K LK E +I + KQ
Sbjct: 412 QLQDQLDAELE-----DKRKVLLELSREKAQNEDLKLEVTNILQKHKQ 454
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/245 (19%), Positives = 113/245 (46%), Gaps = 28/245 (11%)
Query: 509 REDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRA 568
+E ++V +P+ E F+ + + + SE+++ +E +L
Sbjct: 965 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK--- 1021
Query: 569 TQVFREQYILKQDLAKE--------EIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAE 620
+E + L++DL + E++R + D+ KQL+DLS E K+++E
Sbjct: 1022 ----KEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE--- 1074
Query: 621 RLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAI- 679
K E KQ + ++ LL H L + ++ + ++ + ++L+ +
Sbjct: 1075 ----KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE 1130
Query: 680 -KQVTMKKDYQQQKMEKVLSLP--KPTIILSAYQRK--CIQSILKEEGEHIREMVKQIND 734
+Q T+ K +Q + +K S+P + I A++++ I++ L+E+ E + +++++
Sbjct: 1131 KEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK 1190
Query: 735 IRNHV 739
+++ V
Sbjct: 1191 LQSEV 1195
Score = 37.4 bits (85), Expect = 0.051
Identities = 35/156 (22%), Positives = 64/156 (41%), Gaps = 36/156 (23%)
Query: 577 ILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERK-----------SLREMAERL--- 622
I + ++ EE +R L ++ K+ ++LS C ER+ +E++ +L
Sbjct: 554 IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 613
Query: 623 --ADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLR------- 673
A+K+E K + +N K L E R +K+EL+ + +L
Sbjct: 614 IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 673
Query: 674 -------------HLGNAIKQVTMKKDYQQQKMEKV 696
LG I ++T+K Q+++EKV
Sbjct: 674 HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 709
Score = 30.4 bits (67), Expect = 6.2
Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 13/114 (11%)
Query: 584 KEEIQRRVKLLCDQKKKQLEDLSYCREER-------KSLREMAERLADKYEEAKE----- 631
+ E+Q + L + +++ DLS + + SL E L KYEE E
Sbjct: 1192 QSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHA 1251
Query: 632 KQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK 685
K+++I + +K L F E + ER K L I + R + + KQ+ K
Sbjct: 1252 KKKEISAKDEKELLHFSIEQEIKDQKER-CDKSLTTITELQRRIQESAKQIEAK 1304
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/245 (19%), Positives = 113/245 (46%), Gaps = 28/245 (11%)
Query: 509 REDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRA 568
+E ++V +P+ E F+ + + + SE+++ +E +L
Sbjct: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK--- 1034
Query: 569 TQVFREQYILKQDLAKE--------EIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAE 620
+E + L++DL + E++R + D+ KQL+DLS E K+++E
Sbjct: 1035 ----KEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE--- 1087
Query: 621 RLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAI- 679
K E KQ + ++ LL H L + ++ + ++ + ++L+ +
Sbjct: 1088 ----KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE 1143
Query: 680 -KQVTMKKDYQQQKMEKVLSLP--KPTIILSAYQRK--CIQSILKEEGEHIREMVKQIND 734
+Q T+ K +Q + +K S+P + I A++++ I++ L+E+ E + +++++
Sbjct: 1144 KEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK 1203
Query: 735 IRNHV 739
+++ V
Sbjct: 1204 LQSEV 1208
Score = 37.4 bits (85), Expect = 0.051
Identities = 35/156 (22%), Positives = 64/156 (41%), Gaps = 36/156 (23%)
Query: 577 ILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERK-----------SLREMAERL--- 622
I + ++ EE +R L ++ K+ ++LS C ER+ +E++ +L
Sbjct: 567 IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 626
Query: 623 --ADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLR------- 673
A+K+E K + +N K L E R +K+EL+ + +L
Sbjct: 627 IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 686
Query: 674 -------------HLGNAIKQVTMKKDYQQQKMEKV 696
LG I ++T+K Q+++EKV
Sbjct: 687 HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Score = 30.4 bits (67), Expect = 6.2
Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 13/114 (11%)
Query: 584 KEEIQRRVKLLCDQKKKQLEDLSYCREER-------KSLREMAERLADKYEEAKE----- 631
+ E+Q + L + +++ DLS + + SL E L KYEE E
Sbjct: 1205 QSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHA 1264
Query: 632 KQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMK 685
K+++I + +K L F E + ER K L I + R + + KQ+ K
Sbjct: 1265 KKKEISAKDEKELLHFSIEQEIKDQKER-CDKSLTTITELQRRIQESAKQIEAK 1317
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 40.8 bits (94), Expect = 0.005
Identities = 46/214 (21%), Positives = 95/214 (44%), Gaps = 21/214 (9%)
Query: 531 KHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQ-------VFREQYILKQDLA 583
+H+R LQ L+ + K++ +E L L + Q + E +L+Q +
Sbjct: 14 RHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVL 73
Query: 584 K-----EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMN 638
+ EEI+R L K+K E+ + RE + + + +R+A+ EK E+ +
Sbjct: 74 RIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE-----LEKLEEAFS 128
Query: 639 RMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLS 698
R K + ++L + + ER++ K++ + LR ++ + D +Q + L
Sbjct: 129 RSK----NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELE 184
Query: 699 LPKPTIILSAYQRKCIQSILKEEGEHIREMVKQI 732
K + +RK + KE + I+E+ +++
Sbjct: 185 KLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL 218
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 40.8 bits (94), Expect = 0.005
Identities = 46/214 (21%), Positives = 95/214 (44%), Gaps = 21/214 (9%)
Query: 531 KHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQ-------VFREQYILKQDLA 583
+H+R LQ L+ + K++ +E L L + Q + E +L+Q +
Sbjct: 14 RHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVL 73
Query: 584 K-----EEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMN 638
+ EEI+R L K+K E+ + RE + + + +R+A+ EK E+ +
Sbjct: 74 RIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE-----LEKLEEAFS 128
Query: 639 RMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLS 698
R K + ++L + + ER++ K++ + LR ++ + D +Q + L
Sbjct: 129 RSK----NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELE 184
Query: 699 LPKPTIILSAYQRKCIQSILKEEGEHIREMVKQI 732
K + +RK + KE + I+E+ +++
Sbjct: 185 KLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL 218
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/136 (27%), Positives = 65/136 (47%), Gaps = 17/136 (12%)
Query: 547 LKASEKDIAPPPEECLQLLSRATQVFREQYILKQ--DLAKEEIQRRVKLLCDQKKKQLED 604
L+A EK++ +QL + T EQY K+ DL E L ++K K E
Sbjct: 471 LQAREKEVHDLE---IQLTAITTS---EQYYSKEVKDLKTE--------LENEKLKNTEL 516
Query: 605 LSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKE 664
S+C + +E+ + +D E K +QEDI N KK ++ L ++E ++ E
Sbjct: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDI-NNNKKQEERMLKQIENLQETETQLRNE 575
Query: 665 LQLIPDQLRHLGNAIK 680
L+ + ++L+ + +K
Sbjct: 576 LEYVREELKQKRDEVK 591
Score = 30.8 bits (68), Expect = 4.7
Identities = 28/126 (22%), Positives = 61/126 (48%), Gaps = 18/126 (14%)
Query: 578 LKQDLAKE--EIQRRVKLLCDQ---KKKQLEDLSYCREERKSLREMAERLADKYEEAKEK 632
L+Q+ KE + +++V LL Q K+ +++DL++ EE + DK + +EK
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESR----------DKVNQLEEK 302
Query: 633 QEDIMNRMKKLLHSFHSELPVLSDSERDMKKEL---QLIPDQLRHLGNAIKQVTMKKDYQ 689
+ +K+ + H L D + +++ + + + + L+ I Q+T +K+ Q
Sbjct: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
Query: 690 QQKMEK 695
++ K
Sbjct: 363 MEESNK 368
Score = 30.0 bits (66), Expect = 8.1
Identities = 22/113 (19%), Positives = 52/113 (46%), Gaps = 7/113 (6%)
Query: 584 KEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKL 643
+E + ++++ L + + + +L Y REE K R+ + DK EE N ++K
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN-------CNNLRKQ 607
Query: 644 LHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKV 696
+ + + + L + +KK+ QL + ++ ++ + +QK ++
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEI 660
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 40.8 bits (94), Expect = 0.005
Identities = 47/227 (20%), Positives = 92/227 (40%), Gaps = 31/227 (13%)
Query: 527 DSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEE 586
+++E+ IR + Q + L+ S + + + L SRA +K+ EE
Sbjct: 441 EAYERRIRRLEQEKLELSRKLQESTQTV-----QSLHGSSRALSNSNRDKEIKK--LNEE 493
Query: 587 IQRRVKLLCDQKK--KQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLL 644
I+R + D + +QLED R+ER+ + L ++ ++++E++ ++ +
Sbjct: 494 IERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEAS 553
Query: 645 HSFHSELPVLSDSER-----------------DMKKELQLIPDQLRHLGNAIKQVTMKKD 687
S+ L D+ + +++ + Q + QLR ++ T K D
Sbjct: 554 ERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVD 613
Query: 688 YQQQKMEKVLSLPKPTIILSAYQRKCIQSILKEE--GEHIREMVKQI 732
+Q+M + L K L A + KE EH KQ+
Sbjct: 614 AMRQEMRRAEKLRKE---LEAQLDDAVAEASKERKLREHSENFCKQM 657
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,070,928
Number of Sequences: 37866
Number of extensions: 1613019
Number of successful extensions: 7942
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 407
Number of HSP's that attempted gapping in prelim test: 6498
Number of HSP's gapped (non-prelim): 1538
length of query: 741
length of database: 18,247,518
effective HSP length: 110
effective length of query: 631
effective length of database: 14,082,258
effective search space: 8885904798
effective search space used: 8885904798
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.