Search of human proteins with 239916002

Search of human proteins with 239916002

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239916002 lens intrinsic membrane protein 2, 19kDa isoform 2
[Homo sapiens]
         (173 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239916002 lens intrinsic membrane protein 2, 19kDa isoform 2 ...   363   e-101
gi|21361300 lens intrinsic membrane protein 2, 19kDa isoform 1 [...   343   4e-95
gi|4503559 epithelial membrane protein 1 [Homo sapiens]                56   1e-08
gi|22748765 claudin domain containing 2 [Homo sapiens]                 55   4e-08
gi|5031949 natural killer cell group 7 sequence [Homo sapiens]         51   6e-07
gi|122937323 transmembrane protein 202 [Homo sapiens]                  49   2e-06
gi|4503561 epithelial membrane protein 2 [Homo sapiens]                45   3e-05
gi|4505907 peripheral myelin protein 22 [Homo sapiens]                 43   2e-04
gi|24430165 peripheral myelin protein 22 [Homo sapiens]                43   2e-04
gi|24430163 peripheral myelin protein 22 [Homo sapiens]                43   2e-04
gi|50345279 claudin 18 isoform 2 [Homo sapiens]                        43   2e-04
gi|5174405 voltage-dependent calcium channel gamma-2 subunit [Ho...    38   0.004
gi|5729756 voltage-dependent calcium channel gamma-3 subunit [Ho...    38   0.004
gi|239747698 PREDICTED: similar to hCG1784039 [Homo sapiens]           37   0.009
gi|7705961 claudin 18 isoform 1 [Homo sapiens]                         37   0.009
gi|4502539 voltage-dependent calcium channel gamma-1 subunit [Ho...    37   0.009
gi|22027551 voltage-dependent calcium channel gamma-5 subunit is...    36   0.015
gi|24586686 voltage-dependent calcium channel gamma-8 subunit [H...    36   0.019
gi|13899273 transmembrane protein 47 [Homo sapiens]                    35   0.025
gi|7656948 voltage-dependent calcium channel gamma-4 subunit [Ho...    35   0.025
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14...    34   0.055
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14...    34   0.055
gi|239756473 PREDICTED: transmembrane protein 114 [Homo sapiens]       34   0.072
gi|239752599 PREDICTED: transmembrane protein 114, partial [Homo...    34   0.072
gi|226437592 transmembrane protein 114 [Homo sapiens]                  34   0.072
gi|7656981 claudin 15 [Homo sapiens]                                   34   0.072
gi|10938016 claudin 11 [Homo sapiens]                                  33   0.094
gi|7656950 voltage-dependent calcium channel gamma-5 subunit iso...    33   0.12 
gi|5729970 claudin 16 [Homo sapiens]                                   32   0.21 
gi|33598916 claudin 10 isoform a [Homo sapiens]                        32   0.27 

>gi|239916002 lens intrinsic membrane protein 2, 19kDa isoform 2
           [Homo sapiens]
          Length = 173

 Score =  363 bits (933), Expect = e-101
 Identities = 173/173 (100%), Positives = 173/173 (100%)

Query: 1   MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAY 60
           MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAY
Sbjct: 1   MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAY 60

Query: 61  WNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYT 120
           WNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYT
Sbjct: 61  WNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYT 120

Query: 121 GVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR 173
           GVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR
Sbjct: 121 GVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR 173


>gi|21361300 lens intrinsic membrane protein 2, 19kDa isoform 1
           [Homo sapiens]
          Length = 215

 Score =  343 bits (880), Expect = 4e-95
 Identities = 173/215 (80%), Positives = 173/215 (80%), Gaps = 42/215 (19%)

Query: 1   MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSI-- 58
           MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSI  
Sbjct: 1   MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIGE 60

Query: 59  ----------------------------------------AYWNATRAFMILSALCAISG 78
                                                   AYWNATRAFMILSALCAISG
Sbjct: 61  PPGQGPGRAWGKSRADLGAQGHLYSRWRTLRLKEGKGATQAYWNATRAFMILSALCAISG 120

Query: 79  IIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFGDWRFSW 138
           IIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFGDWRFSW
Sbjct: 121 IIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFGDWRFSW 180

Query: 139 SYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR 173
           SYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR
Sbjct: 181 SYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR 215


>gi|4503559 epithelial membrane protein 1 [Homo sapiens]
          Length = 157

 Score = 56.2 bits (134), Expect = 1e-08
 Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 19/158 (12%)

Query: 8   GLFCAWVGT-ILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAYWN---- 62
           G+F   + T I+L V+   + W+        A  GLW+ C    C   +DS++Y +    
Sbjct: 7   GIFVVHIATVIMLFVSTIANVWLVSNTVD--ASVGLWKNCTNISC---SDSLSYASEDAL 61

Query: 63  -ATRAFMILSAL-CAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYT 120
              +AFMILS + C I+ ++     F    T  + +R F +G       L +++ ++IYT
Sbjct: 62  KTVQAFMILSIIFCVIALLVFVFQLF----TMEKGNRFFLSGATTLVCWLCILVGVSIYT 117

Query: 121 GVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYM 158
                +  R    +   +SYILGW+    +F  G+ Y+
Sbjct: 118 S---HYANRDGTQYHHGYSYILGWICFCFSFIIGVLYL 152


>gi|22748765 claudin domain containing 2 [Homo sapiens]
          Length = 167

 Score = 54.7 bits (130), Expect = 4e-08
 Identities = 42/158 (26%), Positives = 70/158 (44%), Gaps = 13/158 (8%)

Query: 3   SFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAYWN 62
           S   GG+  + V  +L+V++ AT++W + +      H GLW+ C    C           
Sbjct: 6   SLQSGGILLSLVANVLMVLSTATNYWTRQQEG----HSGLWQECNHGICS-SIPCQTTLA 60

Query: 63  ATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGV 122
            T A M+L+    + G++MG+     +       R  +     F   L ++ AL  YT V
Sbjct: 61  VTVACMVLAVGVGVVGMVMGLRIRCDE---GESLRGQTTSAFLFLGGLLLLTALIGYT-V 116

Query: 123 TVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCA 160
             ++    F    FSWSY  GW+A+  +  AG  ++ A
Sbjct: 117 KNAWKNNVF----FSWSYFSGWLALPFSILAGFCFLLA 150


>gi|5031949 natural killer cell group 7 sequence [Homo sapiens]
          Length = 165

 Score = 50.8 bits (120), Expect = 6e-07
 Identities = 40/160 (25%), Positives = 72/160 (45%), Gaps = 14/160 (8%)

Query: 3   SFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIA-YW 61
           + +GG L     G +  ++A++TD W +       AH GLW    G       D I+ Y 
Sbjct: 8   ALLGGSL-----GLMFCLIALSTDFWFEAVGPTHSAHSGLWPTGHG-------DIISGYI 55

Query: 62  NATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTG 121
           + T+ F I++ L A+  +   +++      F     P  +    F++ + +V+A+A+YT 
Sbjct: 56  HVTQTFSIMAVLWALVSVSFLVLS-CFPSLFPPGHGPLVSTTAAFAAAISMVVAMAVYTS 114

Query: 122 VTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAY 161
                         FSWS+ LGWV+ ++    G   + A+
Sbjct: 115 ERWDQPPHPQIQTFFSWSFYLGWVSAILLLCTGALSLGAH 154


>gi|122937323 transmembrane protein 202 [Homo sapiens]
          Length = 273

 Score = 49.3 bits (116), Expect = 2e-06
 Identities = 35/157 (22%), Positives = 72/157 (45%), Gaps = 6/157 (3%)

Query: 8   GLFCAWVGTILLVVAMATDHWMQYRL--SGSFAHQGLWRYCLGNKCYLQTDSIAYW-NAT 64
           G  C++  ++L+++AM+  +W+Q+ +  +G   + GLW  C    C+  T    Y+   +
Sbjct: 61  GSLCSF--SLLMLIAMSPLNWVQFLVIKNGLELYAGLWTLCNHELCWSHTPKPPYYLQYS 118

Query: 65  RAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTV 124
           RAF ++S    ++G+     ++         +      ++ F S   ++L L ++    V
Sbjct: 119 RAFFLISVFTILTGLGWLFSSWILNRGSMTTNLDLKVSMLSFISATCLLLCLNLFVA-QV 177

Query: 125 SFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAY 161
            +  R   +    W+Y L W + +   FAGI  +  Y
Sbjct: 178 HWHTRDAMESDLLWTYYLNWCSDIFYMFAGIISLLNY 214


>gi|4503561 epithelial membrane protein 2 [Homo sapiens]
          Length = 167

 Score = 45.1 bits (105), Expect = 3e-05
 Identities = 43/152 (28%), Positives = 64/152 (42%), Gaps = 19/152 (12%)

Query: 18  LLVVAMATDHWMQYRLSGSFAHQGLWRYCLGN-KCYLQTDSIAYWN---ATRAFMILSA- 72
           LL +A   + W      G      +WR C  N  C +  DS   ++   A +A MILS  
Sbjct: 18  LLFIATVDNAWWV----GDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTI 73

Query: 73  LCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFG 132
           LC I+  I  +  F       +  R     I+   S L V++A +IYT        +   
Sbjct: 74  LCCIAFFIFVLQLFR----LKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAK 129

Query: 133 ------DWRFSWSYILGWVAVLMTFFAGIFYM 158
                 +  + +SYIL WVA   TF +G+ Y+
Sbjct: 130 FYPVTREGSYGYSYILAWVAFACTFISGMMYL 161


>gi|4505907 peripheral myelin protein 22 [Homo sapiens]
          Length = 160

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 14/147 (9%)

Query: 17  ILLVVAMATDHWMQYRLSGSFAHQGLWRYCL----GNKCYLQTDSIAYW-NATRAFMILS 71
           +LL V+     W    + G+     LW+ C     GN  +  + S   W  + +A MILS
Sbjct: 17  VLLFVSTIVSQW----IVGNGHATDLWQNCSTSSSGNVHHCFSSSPNEWLQSVQATMILS 72

Query: 72  ALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRF 131
            + +I  + +    F    T ++  R +  GI    + L V+ A AIYT     +     
Sbjct: 73  IIFSILSLFL---FFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYTVRHPEW--HLN 127

Query: 132 GDWRFSWSYILGWVAVLMTFFAGIFYM 158
            D+ + ++YIL WVA  +   +G+ Y+
Sbjct: 128 SDYSYGFAYILAWVAFPLALLSGVIYV 154


>gi|24430165 peripheral myelin protein 22 [Homo sapiens]
          Length = 160

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 14/147 (9%)

Query: 17  ILLVVAMATDHWMQYRLSGSFAHQGLWRYCL----GNKCYLQTDSIAYW-NATRAFMILS 71
           +LL V+     W    + G+     LW+ C     GN  +  + S   W  + +A MILS
Sbjct: 17  VLLFVSTIVSQW----IVGNGHATDLWQNCSTSSSGNVHHCFSSSPNEWLQSVQATMILS 72

Query: 72  ALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRF 131
            + +I  + +    F    T ++  R +  GI    + L V+ A AIYT     +     
Sbjct: 73  IIFSILSLFL---FFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYTVRHPEW--HLN 127

Query: 132 GDWRFSWSYILGWVAVLMTFFAGIFYM 158
            D+ + ++YIL WVA  +   +G+ Y+
Sbjct: 128 SDYSYGFAYILAWVAFPLALLSGVIYV 154


>gi|24430163 peripheral myelin protein 22 [Homo sapiens]
          Length = 160

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 14/147 (9%)

Query: 17  ILLVVAMATDHWMQYRLSGSFAHQGLWRYCL----GNKCYLQTDSIAYW-NATRAFMILS 71
           +LL V+     W    + G+     LW+ C     GN  +  + S   W  + +A MILS
Sbjct: 17  VLLFVSTIVSQW----IVGNGHATDLWQNCSTSSSGNVHHCFSSSPNEWLQSVQATMILS 72

Query: 72  ALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRF 131
            + +I  + +    F    T ++  R +  GI    + L V+ A AIYT     +     
Sbjct: 73  IIFSILSLFL---FFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYTVRHPEW--HLN 127

Query: 132 GDWRFSWSYILGWVAVLMTFFAGIFYM 158
            D+ + ++YIL WVA  +   +G+ Y+
Sbjct: 128 SDYSYGFAYILAWVAFPLALLSGVIYV 154


>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
          Length = 261

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 40/191 (20%), Positives = 72/191 (37%), Gaps = 35/191 (18%)

Query: 6   GGGLFCAWVGTILLVVAMATDHWMQYRLSGS-----FAHQGLWRYCLGNKCYLQTDSIAY 60
           G G   + +G   ++ A   D W    L  +     F +QGLWR C+       T+   Y
Sbjct: 8   GLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGF-TECRGY 66

Query: 61  W---------NATRAFMILSALCAISGIIMGIMA-----FAHQPTFSRISRPFSAGIMFF 106
           +          A RA MI+  +    G+++ I A            ++ +   ++GIMF 
Sbjct: 67  FTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFI 126

Query: 107 SSTLFVVLALAIYTGVTVSFLGRRFGD---------------WRFSWSYILGWVAVLMTF 151
            S L  +  ++++  + V+       +               + F  +  +GWVA  +T 
Sbjct: 127 VSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTL 186

Query: 152 FAGIFYMCAYR 162
             G+    A R
Sbjct: 187 IGGVMMCIACR 197


>gi|5174405 voltage-dependent calcium channel gamma-2 subunit [Homo
           sapiens]
          Length = 323

 Score = 38.1 bits (87), Expect = 0.004
 Identities = 39/179 (21%), Positives = 67/179 (37%), Gaps = 35/179 (19%)

Query: 12  AWVGTILLVVAMATDHWMQYR----------------LSGSFAHQGLWRYCL--GN---- 49
           A+    L+ +A+ TD+W+  R                      H GLWR C   GN    
Sbjct: 17  AFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGL 76

Query: 50  ---------KCYLQTDSIAYW-NATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPF 99
                        + D+  Y+  A RA  I   L  I   + G+   A +   +R +   
Sbjct: 77  CKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIIL 136

Query: 100 SAGIMFFSSTLFVVLALAIYTGVTV---SFLGRRFGDWRFSWSYILGWVAVLMTFFAGI 155
           SAGI F S+ L  ++ + +Y        S    +   + + WS+  G ++ ++    G+
Sbjct: 137 SAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGV 195


>gi|5729756 voltage-dependent calcium channel gamma-3 subunit [Homo
           sapiens]
          Length = 315

 Score = 38.1 bits (87), Expect = 0.004
 Identities = 40/187 (21%), Positives = 67/187 (35%), Gaps = 40/187 (21%)

Query: 12  AWVGTILLVVAMATDHWMQYR----------------LSGSFAHQGLWRYCLGNKCY--- 52
           A+    L+ +A+ TD+W+  R                      H GLWR C     +   
Sbjct: 17  AFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGV 76

Query: 53  ------------LQTDSIAYW----NATRAFMILSALCAISGIIMGIMAFAHQPTFSRIS 96
                        + D+  Y      A+  F ILS      G   G+   A +   SR +
Sbjct: 77  CKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFG---GLCVAASEFHRSRHN 133

Query: 97  RPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFG--DWRFSWSYILGWVAVLMTFFAG 154
              SAGI F S+ L  ++ + +Y        G+R     + + WS+  G  + ++    G
Sbjct: 134 VILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVG 193

Query: 155 IFYMCAY 161
           +  +  Y
Sbjct: 194 VVAVHIY 200


>gi|239747698 PREDICTED: similar to hCG1784039 [Homo sapiens]
          Length = 161

 Score = 37.0 bits (84), Expect = 0.009
 Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 15/147 (10%)

Query: 18  LLVVAMATDHWMQYRLSGSFAHQGLWRYCLGN-KCYLQTDSIAYWNATRAFMILSALCAI 76
           LL +A   + W      G+     +WR C  N KC +  DS   ++  RA  +   + A+
Sbjct: 18  LLFIATIDNAWWV----GNEFFADVWRICTKNTKCTVINDSFKEYSMGRARWLTPVIPAL 73

Query: 77  -SGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTG----VTVSFLGRRF 131
                 G+     + + + I +      M   S L +++A +IYT      T  +   + 
Sbjct: 74  WEAEACGLXGQEIETSLANIMKLLHHATM---SYLCLMIAASIYTDRRDETTDFYYLTKE 130

Query: 132 GDWRFSWSYILGWVAVLMTFFAGIFYM 158
           G   + +SYIL WVA   TF + + Y+
Sbjct: 131 GS--YGYSYILAWVAFAFTFISSMMYL 155


>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
          Length = 261

 Score = 37.0 bits (84), Expect = 0.009
 Identities = 36/177 (20%), Positives = 66/177 (37%), Gaps = 35/177 (19%)

Query: 20  VVAMATDHWMQYRL-----SGSFAHQGLWRYCLGNKCYLQTDSIAYW---------NATR 65
           + A   D W    L     +  F ++GLWR C+       T+   Y+          A R
Sbjct: 22  IAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGF-TECRPYFTILGLPAMLQAVR 80

Query: 66  AFMILSALCAISGIIMGIMA-----FAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYT 120
           A MI+  +    G+++ I A            ++ +   ++GIMF  S L  +  ++++ 
Sbjct: 81  ALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFA 140

Query: 121 GVTVSFLGRRFGD---------------WRFSWSYILGWVAVLMTFFAGIFYMCAYR 162
            + V+       +               + F  +  +GWVA  +T   G+    A R
Sbjct: 141 NMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACR 197


>gi|4502539 voltage-dependent calcium channel gamma-1 subunit
          [Homo sapiens]
          Length = 222

 Score = 37.0 bits (84), Expect = 0.009
 Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 7/45 (15%)

Query: 9  LFCAWVGTILLVVAMATDHWM-------QYRLSGSFAHQGLWRYC 46
          LFC   G +L + A+ TDHW         +  +   AH GLWR C
Sbjct: 13 LFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRIC 57


>gi|22027551 voltage-dependent calcium channel gamma-5 subunit
           isoform a [Homo sapiens]
          Length = 275

 Score = 36.2 bits (82), Expect = 0.015
 Identities = 40/179 (22%), Positives = 71/179 (39%), Gaps = 42/179 (23%)

Query: 15  GTILLVVAMATDHWMQYRLSGSFA------------HQGLWRYCL-----GNKCY----- 52
           G  LL +A++TD+W+ Y   G               H GLWR C        +C+     
Sbjct: 20  GLGLLGIAVSTDYWL-YLEEGVIVPQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYV 78

Query: 53  ------LQTDS----IAYWNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAG 102
                 L ++S    +    +   F ++S      G I+  +         R    F +G
Sbjct: 79  MPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIRP---HRTILAFVSG 135

Query: 103 IMFFSSTLFVVLALAIY-TGVTVSFLGRR-----FGDWRFSWSYILGWVAVLMTFFAGI 155
           I F  S L +V+ L +Y + +    L R      + ++++ WS+    ++ L+T  AG+
Sbjct: 136 IFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLTESAGV 194


>gi|24586686 voltage-dependent calcium channel gamma-8 subunit [Homo
           sapiens]
          Length = 425

 Score = 35.8 bits (81), Expect = 0.019
 Identities = 37/194 (19%), Positives = 66/194 (34%), Gaps = 50/194 (25%)

Query: 18  LLVVAMATDHWMQYRL-----------------------------SGSFAHQGLWRYC-- 46
           L+ +A++TD+W+  R                               G   H GLWR C  
Sbjct: 34  LMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCL 93

Query: 47  -------------LGNKCYLQTDSIAY-WNATRAFMILSALCAISGIIMGIMAFAHQPTF 92
                                 DS  Y     RA  I   L AI  ++ G+   A +   
Sbjct: 94  EGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYK 153

Query: 93  SRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLG-----RRFGDWRFSWSYILGWVAV 147
           S+ +    AGI+F ++ L  ++ + +Y        G      +   + + WS+  G ++ 
Sbjct: 154 SKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSF 213

Query: 148 LMTFFAGIFYMCAY 161
           ++    G+  +  Y
Sbjct: 214 ILAEVIGVLAVNIY 227


>gi|13899273 transmembrane protein 47 [Homo sapiens]
          Length = 181

 Score = 35.4 bits (80), Expect = 0.025
 Identities = 36/159 (22%), Positives = 68/159 (42%), Gaps = 20/159 (12%)

Query: 8   GLFCAWVGTILLVVAMATDHWM----QYRLSGSFAHQGLWRYCLGNKC----YLQTDSIA 59
           GL C ++   L + A+ +  W+    QY LS       LW  C         + ++   +
Sbjct: 23  GLVCIFLALCLDLGAVLSPAWVTADHQYYLS-------LWESCRKPASLDIWHCESTLSS 75

Query: 60  YWN-ATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAI 118
            W  AT A ++  A   +   ++G+++     +  R  RP +  +M F++ +  V +L +
Sbjct: 76  DWQIATLALLLGGAAIILIAFLVGLISIC-VGSRRRFYRPVA--VMLFAAVVLQVCSLVL 132

Query: 119 YTGVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFY 157
           Y    +  +  +     F+W Y L W A + +F   I Y
Sbjct: 133 YPIKFIETVSLKIYH-EFNWGYGLAWGATIFSFGGAILY 170


>gi|7656948 voltage-dependent calcium channel gamma-4 subunit [Homo
           sapiens]
          Length = 327

 Score = 35.4 bits (80), Expect = 0.025
 Identities = 41/193 (21%), Positives = 72/193 (37%), Gaps = 46/193 (23%)

Query: 12  AWVGTILLVVAMATDHWMQY-------------------RLSGSFAHQGLWRYCLGNKCY 52
           A+    L+ +A+ TD+W+                     R  G   H GLWR C     Y
Sbjct: 17  AFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDDGPPPRRARGDLTHSGLWRVCCIEGIY 76

Query: 53  ---------------LQTDSIAYW----NATRAFMILSALCAISGIIMGIMAFAHQPTFS 93
                             DS  Y      A+  F ILS +  + G   G+   A +    
Sbjct: 77  KGHCFRINHFPEDNDYDHDSSEYLLRIVRASSVFPILSTILLLLG---GLCIGAGRIYSR 133

Query: 94  RISRPFSAGIMFFSSTLFVVLALAIY-TGVTVSFLGRRFGD----WRFSWSYILGWVAVL 148
           + +   SAGI+F ++ L  ++ + +Y +  T     +R  D    + + WS+  G ++ +
Sbjct: 134 KNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFI 193

Query: 149 MTFFAGIFYMCAY 161
           +    G+  +  Y
Sbjct: 194 VAETVGVLAVNIY 206


>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
           isoform 2 [Homo sapiens]
          Length = 662

 Score = 34.3 bits (77), Expect = 0.055
 Identities = 18/46 (39%), Positives = 29/46 (63%), Gaps = 2/46 (4%)

Query: 69  ILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVL 114
           ++S+L AI+GI   I+++ HQ  + ++  P    I  FS TLF+VL
Sbjct: 98  VISSLVAITGITFTILSYRHQDKYCQM--PSFEEICVFSRTLFIVL 141


>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
           isoform 1 [Homo sapiens]
          Length = 679

 Score = 34.3 bits (77), Expect = 0.055
 Identities = 18/46 (39%), Positives = 29/46 (63%), Gaps = 2/46 (4%)

Query: 69  ILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVL 114
           ++S+L AI+GI   I+++ HQ  + ++  P    I  FS TLF+VL
Sbjct: 115 VISSLVAITGITFTILSYRHQDKYCQM--PSFEEICVFSRTLFIVL 158


>gi|239756473 PREDICTED: transmembrane protein 114 [Homo sapiens]
          Length = 223

 Score = 33.9 bits (76), Expect = 0.072
 Identities = 33/158 (20%), Positives = 58/158 (36%), Gaps = 31/158 (19%)

Query: 38  AHQGLWRYC-LGNKCYLQTDSIAYWNATRA------------FMIL---SALCAISGIIM 81
           +H GLWR C + + C    +     N T +            F+IL   S +  + G + 
Sbjct: 64  SHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFGGMT 123

Query: 82  GIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFG--------- 132
           G ++F  Q     +      GI+F    +  +  +++Y   + +                
Sbjct: 124 GFLSFLLQAYLLLLL----TGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLD 179

Query: 133 --DWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRR 168
             D  F WS  LGW++ +     G  ++ A R    RR
Sbjct: 180 QVDISFGWSLALGWISFIAELLTGAAFLAAARELSLRR 217


>gi|239752599 PREDICTED: transmembrane protein 114, partial [Homo
           sapiens]
          Length = 217

 Score = 33.9 bits (76), Expect = 0.072
 Identities = 33/158 (20%), Positives = 58/158 (36%), Gaps = 31/158 (19%)

Query: 38  AHQGLWRYC-LGNKCYLQTDSIAYWNATRA------------FMIL---SALCAISGIIM 81
           +H GLWR C + + C    +     N T +            F+IL   S +  + G + 
Sbjct: 58  SHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFGGMT 117

Query: 82  GIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFG--------- 132
           G ++F  Q     +      GI+F    +  +  +++Y   + +                
Sbjct: 118 GFLSFLLQAYLLLLL----TGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLD 173

Query: 133 --DWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRR 168
             D  F WS  LGW++ +     G  ++ A R    RR
Sbjct: 174 QVDISFGWSLALGWISFIAELLTGAAFLAAARELSLRR 211


>gi|226437592 transmembrane protein 114 [Homo sapiens]
          Length = 223

 Score = 33.9 bits (76), Expect = 0.072
 Identities = 33/158 (20%), Positives = 58/158 (36%), Gaps = 31/158 (19%)

Query: 38  AHQGLWRYC-LGNKCYLQTDSIAYWNATRA------------FMIL---SALCAISGIIM 81
           +H GLWR C + + C    +     N T +            F+IL   S +  + G + 
Sbjct: 64  SHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFGGMT 123

Query: 82  GIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFG--------- 132
           G ++F  Q     +      GI+F    +  +  +++Y   + +                
Sbjct: 124 GFLSFLLQAYLLLLL----TGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLD 179

Query: 133 --DWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRR 168
             D  F WS  LGW++ +     G  ++ A R    RR
Sbjct: 180 QVDISFGWSLALGWISFIAELLTGAAFLAAARELSLRR 217


>gi|7656981 claudin 15 [Homo sapiens]
          Length = 228

 Score = 33.9 bits (76), Expect = 0.072
 Identities = 36/169 (21%), Positives = 67/169 (39%), Gaps = 21/169 (12%)

Query: 8   GLFCAWVGTILLVVAMATDHWMQYRLSGSF-----AHQGLWRYCLGN-----KCYLQTDS 57
           G F A VG ++L V +   +W    + G+        + LW  C  +      C+     
Sbjct: 9   GFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNCWEFPSM 68

Query: 58  IA---YWNATRAFMILSALCAISGIIMGIMA-----FAHQPTFSRISRPFSAGIMFFSST 109
           +A   Y  A RA MI + L    G+++GI               +     +AG +   + 
Sbjct: 69  LALSGYIQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHILAG 128

Query: 110 LFVVLALAIYT-GVTVSFLGRRFGDWRFSW--SYILGWVAVLMTFFAGI 155
           +  ++A++ Y   +T  F    +   ++    +  LGW A L++   G+
Sbjct: 129 ICGMVAISWYAFNITRDFFDPLYPGTKYELGPALYLGWSASLISILGGL 177


>gi|10938016 claudin 11 [Homo sapiens]
          Length = 207

 Score = 33.5 bits (75), Expect = 0.094
 Identities = 36/172 (20%), Positives = 67/172 (38%), Gaps = 24/172 (13%)

Query: 8   GLFCAWVGTILLVVAMATDHWM--------QYRLSGSFAHQGLWRYCLGNK----CYLQT 55
           G   ++VG I ++V  +T+ W+          R       +GLW  C+       C    
Sbjct: 10  GFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLV 69

Query: 56  DSI---AYWNATRAFMILSALCAISGIIMGI-----MAFAHQPTFSRISRPFSAGIMFFS 107
           D +    Y  A RA MI +++  +  I++ +     +    +P  ++  R   AG++   
Sbjct: 70  DILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLIL 129

Query: 108 STLFVVLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMC 159
             L  ++A  I+  V      R      F +S   GW+  ++    G   +C
Sbjct: 130 LALCALVA-TIWFPVCAH---RETTIVSFGYSLYAGWIGAVLCLVGGCVILC 177


>gi|7656950 voltage-dependent calcium channel gamma-5 subunit
           isoform b [Homo sapiens]
          Length = 296

 Score = 33.1 bits (74), Expect = 0.12
 Identities = 38/174 (21%), Positives = 68/174 (39%), Gaps = 42/174 (24%)

Query: 15  GTILLVVAMATDHWMQYRLSGSFA------------HQGLWRYCL-----GNKCY----- 52
           G  LL +A++TD+W+ Y   G               H GLWR C        +C+     
Sbjct: 20  GLGLLGIAVSTDYWL-YLEEGVIVPQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYV 78

Query: 53  ------LQTDS----IAYWNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAG 102
                 L ++S    +    +   F ++S      G I+  +         R    F +G
Sbjct: 79  MPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIRP---HRTILAFVSG 135

Query: 103 IMFFSSTLFVVLALAIY-TGVTVSFLGR-----RFGDWRFSWSYILGWVAVLMT 150
           I F  S L +V+ L +Y + +    L R      + ++++ WS+    ++ L+T
Sbjct: 136 IFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLT 189


>gi|5729970 claudin 16 [Homo sapiens]
          Length = 305

 Score = 32.3 bits (72), Expect = 0.21
 Identities = 45/181 (24%), Positives = 71/181 (39%), Gaps = 37/181 (20%)

Query: 10  FCAWVGTILLVVAMATDHWM---QYRLSGSFAHQGLWRYCLGN-----KCYLQTDSIAYW 61
           F A+     L+VA  TD WM      L  S   +GLW  C+ N     +   + DSI   
Sbjct: 81  FFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAE 140

Query: 62  N-----ATRAFMILSALCAISG---IIMGI---------------MAFAHQPTFSRISRP 98
           +      TRA MI + + A  G   +++G+               + F    T      P
Sbjct: 141 HPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTP 200

Query: 99  FSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYM 158
              G ++++  ++V  +  +   +   FLG ++   +F WS  LG    L  F AG    
Sbjct: 201 GIIGSVWYAVDVYVERSTLVLHNI---FLGIQY---KFGWSCWLGMAGSLGCFLAGAVLT 254

Query: 159 C 159
           C
Sbjct: 255 C 255


>gi|33598916 claudin 10 isoform a [Homo sapiens]
          Length = 226

 Score = 32.0 bits (71), Expect = 0.27
 Identities = 34/161 (21%), Positives = 60/161 (37%), Gaps = 24/161 (14%)

Query: 19  LVVAMATDHWMQYR-----LSGSFAHQGLWRYCLGN-------KCYLQTDSIA-YWNATR 65
           LV A  ++ W         ++ ++ +QGLW  C GN       + +     +A Y  A R
Sbjct: 19  LVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGYIQACR 78

Query: 66  AFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTG---- 121
             MI +      G I  +  F  + T    S    A I   +  +F++  L   TG    
Sbjct: 79  GLMIAAVSLGFFGSIFAL--FGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLY 136

Query: 122 ---VTVSFLGRRFGDWRFSW--SYILGWVAVLMTFFAGIFY 157
              +T  F    F + ++    +  +GW    +    G+ +
Sbjct: 137 ANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIF 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.335    0.142    0.492 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,935,661
Number of Sequences: 37866
Number of extensions: 212751
Number of successful extensions: 876
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 828
Number of HSP's gapped (non-prelim): 70
length of query: 173
length of database: 18,247,518
effective HSP length: 95
effective length of query: 78
effective length of database: 14,650,248
effective search space: 1142719344
effective search space used: 1142719344
T: 11
A: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.7 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.