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Search of human proteins with 239787821
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239787821 syncoilin, intermediate filament 1 isoform 2 [Homo
sapiens]
(476 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239787821 syncoilin, intermediate filament 1 isoform 2 [Homo ... 927 0.0
gi|166706887 syncoilin, intermediate filament 1 isoform 1 [Homo ... 878 0.0
gi|14249342 internexin neuronal intermediate filament protein, a... 103 3e-22
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 97 4e-20
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 97 4e-20
gi|21264345 peripherin [Homo sapiens] 94 2e-19
gi|62414289 vimentin [Homo sapiens] 91 2e-18
gi|55749932 desmin [Homo sapiens] 87 4e-17
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 82 1e-15
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 81 2e-15
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 79 7e-15
gi|221139761 zinc finger protein 853 [Homo sapiens] 78 2e-14
gi|14917115 keratin 31 [Homo sapiens] 74 2e-13
gi|4504919 keratin 8 [Homo sapiens] 74 3e-13
gi|153791158 keratin 75 [Homo sapiens] 74 3e-13
gi|28173564 keratin 73 [Homo sapiens] 73 5e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 73 5e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 73 5e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 73 5e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 73 5e-13
gi|10337581 type I hair keratin 3B [Homo sapiens] 73 6e-13
gi|119395754 keratin 5 [Homo sapiens] 72 8e-13
gi|14917117 keratin 33A [Homo sapiens] 72 1e-12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 72 1e-12
gi|131412228 keratin 13 isoform b [Homo sapiens] 72 1e-12
gi|131412225 keratin 13 isoform a [Homo sapiens] 72 1e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 72 1e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 72 1e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 72 1e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 72 1e-12
>gi|239787821 syncoilin, intermediate filament 1 isoform 2 [Homo
sapiens]
Length = 476
Score = 927 bits (2396), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY
Sbjct: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
Query: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF
Sbjct: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
Query: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ
Sbjct: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
Query: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR
Sbjct: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
Query: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE
Sbjct: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
Query: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA
Sbjct: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
Query: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER
Sbjct: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
Query: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLEIYGQICNPETAKNFLAKDH 476
QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLEIYGQICNPETAKNFLAKDH
Sbjct: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLEIYGQICNPETAKNFLAKDH 476
>gi|166706887 syncoilin, intermediate filament 1 isoform 1 [Homo
sapiens]
Length = 482
Score = 878 bits (2269), Expect = 0.0
Identities = 454/456 (99%), Positives = 454/456 (99%)
Query: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY
Sbjct: 1 MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILY 60
Query: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF
Sbjct: 61 LEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF 120
Query: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ
Sbjct: 121 VEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQ 180
Query: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR
Sbjct: 181 QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIR 240
Query: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE
Sbjct: 241 LVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKE 300
Query: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA
Sbjct: 301 QLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA 360
Query: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER
Sbjct: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
Query: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCL 456
QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYK L
Sbjct: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAML 456
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 103 bits (258), Expect = 3e-22
Identities = 79/306 (25%), Positives = 150/306 (49%), Gaps = 18/306 (5%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR----EPAL------QEVQQVHQDIL 219
E L+ L RF ++ V QLE + L EL LR EP+ +E++ + +
Sbjct: 96 EQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLE 155
Query: 220 AAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTT 279
A +QA LERDGL EE++ ++ + + ++ + L+ +Q+DV R L
Sbjct: 156 EASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEK 215
Query: 280 RATQLSEELAQLRDAYQKQKEQLRQQLEAPP--------SQRDGHFLQESRRLSAQFENL 331
+ L +ELA +R + ++ +L L+A + R + AQ+E+L
Sbjct: 216 KVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESL 275
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
A++ Q EE Y+ +F L E+ T+A++ ++ EI E + L+ E LR N +
Sbjct: 276 AAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANES 335
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELST 451
LE QI + ++ EV Y++ + ++E R ++ + ++ +++ ++++L E++
Sbjct: 336 LERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAA 395
Query: 452 YKGCLE 457
Y+ LE
Sbjct: 396 YRKLLE 401
Score = 33.1 bits (74), Expect = 0.57
Identities = 36/169 (21%), Positives = 68/169 (40%), Gaps = 9/169 (5%)
Query: 310 PSQRDGHFLQESRRLSAQFENLMAESRQDLE--EEYEPQFLRLLERKEAGTKALQRTQAE 367
P DG L ++ + +++ + ++ L+ + F+ + + E +AL+ A
Sbjct: 69 PPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAA 128
Query: 368 IQ----EMKEALRPLQAEARQLRLQNR---NLEDQIALVRQKRDEEVQQYREQLEEMEER 420
++ E Q E R LR Q + Q L R EEVQ+ R + EE
Sbjct: 129 LRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRG 188
Query: 421 QRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLEIYGQICNPETAK 469
+ ++ QQ+ RL L +++ + L Q+ + E A+
Sbjct: 189 REGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAE 237
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 96.7 bits (239), Expect = 4e-20
Identities = 83/359 (23%), Positives = 159/359 (44%), Gaps = 26/359 (7%)
Query: 119 QFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP-----EESLRAEQSPSVEENLSIEDLE 173
+ + G + PG+ P G ++ A P + SL + +E + E E
Sbjct: 19 EMMVGGLAPGRRLGP------GTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAE 72
Query: 174 LLE--GRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLH------ 225
++E RF ++ V LE++ L EL LR ++ V+Q L +L
Sbjct: 73 MMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTA 132
Query: 226 --AQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQ 283
A+ E+ERD L +++ V+QKL T + + L +Q+ + R L +
Sbjct: 133 NSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIES 192
Query: 284 LSEELAQLRDAYQKQKEQL-----RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQD 338
L EE+ LR ++++ +L RQQ+ + + Q+E + + + +
Sbjct: 193 LEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHE 252
Query: 339 LEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIAL 398
EE Y +F L + + L++ + E + + L+ L + LR N +LE Q+
Sbjct: 253 AEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMRE 312
Query: 399 VRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
++ E Y+E L +EE + L++ + Q+ +++ ++L+L E++TY+ LE
Sbjct: 313 QEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLE 371
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 96.7 bits (239), Expect = 4e-20
Identities = 83/359 (23%), Positives = 159/359 (44%), Gaps = 26/359 (7%)
Query: 119 QFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP-----EESLRAEQSPSVEENLSIEDLE 173
+ + G + PG+ P G ++ A P + SL + +E + E E
Sbjct: 19 EMMVGGLAPGRRLGP------GTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAE 72
Query: 174 LLE--GRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLH------ 225
++E RF ++ V LE++ L EL LR ++ V+Q L +L
Sbjct: 73 MMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTA 132
Query: 226 --AQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQ 283
A+ E+ERD L +++ V+QKL T + + L +Q+ + R L +
Sbjct: 133 NSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIES 192
Query: 284 LSEELAQLRDAYQKQKEQL-----RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQD 338
L EE+ LR ++++ +L RQQ+ + + Q+E + + + +
Sbjct: 193 LEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHE 252
Query: 339 LEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIAL 398
EE Y +F L + + L++ + E + + L+ L + LR N +LE Q+
Sbjct: 253 AEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMRE 312
Query: 399 VRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
++ E Y+E L +EE + L++ + Q+ +++ ++L+L E++TY+ LE
Sbjct: 313 QEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLE 371
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 94.4 bits (233), Expect = 2e-19
Identities = 72/303 (23%), Positives = 151/303 (49%), Gaps = 15/303 (4%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR--EPAL------QEVQQVHQDILAA 221
++L+ L RF ++ V LE++ L EL R EPA QE++++ +++
Sbjct: 99 QELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELL 158
Query: 222 YKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRA 281
+ + ++ERDGL E++ +KQ+L + T++ ++ L ++DV R L +
Sbjct: 159 GRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKI 218
Query: 282 TQLSEELAQLRDAYQKQKEQLRQQLEAPPSQR-------DGHFLQESRRLSAQFENLMAE 334
L +E+ L+ ++++ L+ +E+ Q+ R + AQ+E++ A+
Sbjct: 219 ESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAK 278
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ Q+ EE Y+ ++ L + +AL++ + E+ E + ++ L E LR N L
Sbjct: 279 NLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLR 338
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKG 454
Q+ + ++ E Y+ +EE RQL+ + ++ +E+ ++++L E++TY+
Sbjct: 339 QLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRK 398
Query: 455 CLE 457
LE
Sbjct: 399 LLE 401
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 90.9 bits (224), Expect = 2e-18
Identities = 67/300 (22%), Positives = 148/300 (49%), Gaps = 13/300 (4%)
Query: 171 DLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPAL--------QEVQQVHQDILAAY 222
+L+ L RF + V LE++ L+ EL L+ +E++++ + +
Sbjct: 106 ELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLT 165
Query: 223 KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRAT 282
A+ E+ERD L E+I +++KL + + + L+ +QDV + R L +
Sbjct: 166 NDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVE 225
Query: 283 QLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQES-----RRLSAQFENLMAESRQ 337
L EE+A L+ ++++ ++L+ Q++ Q D + R + Q+E++ A++ Q
Sbjct: 226 SLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQ 285
Query: 338 DLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIA 397
+ EE Y+ +F L E AL++ + E E + ++ L E L+ N +LE Q+
Sbjct: 286 EAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMR 345
Query: 398 LVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
+ + E Y++ + +++ + ++ + ++ +++ ++++L E++TY+ LE
Sbjct: 346 EMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLE 405
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 86.7 bits (213), Expect = 4e-17
Identities = 67/300 (22%), Positives = 145/300 (48%), Gaps = 13/300 (4%)
Query: 171 DLELLEGRFQQCVQAVAQLEEERDQLIHELVLL--REPAL------QEVQQVHQDILAAY 222
+L+ L RF ++ V LE++ L E+ L REP +E++++ + +
Sbjct: 111 ELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEELRELRRQVEVLT 170
Query: 223 KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRAT 282
A+ ++ERD L ++++ +K KL + + + L + DV R L R
Sbjct: 171 NQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIE 230
Query: 283 QLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQES-----RRLSAQFENLMAESRQ 337
L+EE+A L+ ++++ +L+ QL+ Q + + R + AQ+E + A++
Sbjct: 231 SLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNIS 290
Query: 338 DLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIA 397
+ EE Y+ + L + AL++ + E+ E + ++ E L+ N +L Q+
Sbjct: 291 EAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMR 350
Query: 398 LVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
+ + E Y++ + +EE R L++ + ++ +++ ++++L E++TY+ LE
Sbjct: 351 ELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLE 410
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 82.0 bits (201), Expect = 1e-15
Identities = 75/319 (23%), Positives = 139/319 (43%), Gaps = 31/319 (9%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPAL----------QEVQQVHQDIL 219
E L+ L RF + V QLE L E LR+ +EV+++ +L
Sbjct: 99 EQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVL 158
Query: 220 AAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV--- 276
Q LE++ L E+I V+Q+L ++ + + E + +A+FA E
Sbjct: 159 RLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQ----REEAEAAARALARFAQEAEAARV 214
Query: 277 -LTTRATQLSEELAQLRDAYQKQKEQLRQQLEA--------PPSQRDG---HFLQESRRL 324
L +A L EE LR +Q++ +L Q++ RD R +
Sbjct: 215 DLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREI 274
Query: 325 SAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQ 384
AQ E +S EE + + RL E + T A++ Q EI E + L+ E
Sbjct: 275 RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA 334
Query: 385 LRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLS 444
L+ +LE Q + + + ++ Y+E +++++ R + + Q ++ +++ ++++
Sbjct: 335 LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMA 394
Query: 445 LAEELSTYKGCLEIYGQIC 463
L E++ Y+ LE G+ C
Sbjct: 395 LDIEIAAYRKLLE--GEEC 411
Score = 47.0 bits (110), Expect = 4e-05
Identities = 41/147 (27%), Positives = 73/147 (49%), Gaps = 19/147 (12%)
Query: 303 RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKAL- 361
++QL+A + R ++ + R+L A +L E+ L +++AG A+
Sbjct: 98 KEQLQAL-NDRFAGYIDKVRQLEAHNRSLEGEAAA-------------LRQQQAGRSAMG 143
Query: 362 QRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQ 421
+ + E++EM+ A+ L A QLRL+ +L + IA VRQ+ D+E + Q EE E
Sbjct: 144 ELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEAR----QREEAEAAA 199
Query: 422 RQLRNGVQLQQQKNKEMEQLRLSLAEE 448
R L Q + ++++ +L EE
Sbjct: 200 RALARFAQEAEAARVDLQKKAQALQEE 226
Score = 30.0 bits (66), Expect = 4.8
Identities = 55/289 (19%), Positives = 119/289 (41%), Gaps = 48/289 (16%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEE-RDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQA 228
E++ L G+ Q A AQ++ E RD L ++ AL+E++ + L ++
Sbjct: 236 EEVGELLGQIQGSGAAQAQMQAETRDALKCDVT----SALREIRAQLEGHAVQSTLQSEE 291
Query: 229 --ELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSE 286
+ D L E ++ + +E Y+ QL+ R ++ E
Sbjct: 292 WFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL------------------E 333
Query: 287 ELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQ 346
L +D+ ++Q+ +L + +A + + + ++L A+ N E L E +
Sbjct: 334 ALKSTKDSLERQRSELEDRHQADIAS----YQEAIQQLDAELRNTKWEMAAQLREYQDLL 389
Query: 347 FLRLLERKE--AGTKALQRTQAEIQ------EMKEALRPLQAEARQLRLQNRNLEDQIAL 398
+++ E A K L+ + I + E L + + + +++++ E++I +
Sbjct: 390 NVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKS---EEKIKV 446
Query: 399 VRQKRDE--------EVQQYREQLEEMEERQRQLRNGVQLQQQKNKEME 439
V + E E Q E++ E EE++ + G + + + +E E
Sbjct: 447 VEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE 495
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 80.9 bits (198), Expect = 2e-15
Identities = 57/304 (18%), Positives = 146/304 (48%), Gaps = 16/304 (5%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPAL----------QEVQQVHQDIL 219
E L+ L RF ++ V LE++ ++ E+ LR+ QE++++ +
Sbjct: 103 EQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLE 162
Query: 220 AAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTT 279
AQ +L+ D L E+I +K++ + + + + ++D+ + + + L
Sbjct: 163 MVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDK 222
Query: 280 RATQLSEELAQLRDAYQKQKEQLRQQLEAP--PSQRDGHFLQE----SRRLSAQFENLMA 333
+ L +E+A LR ++++ L Q++A +R + + + + +Q E+
Sbjct: 223 KVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSD 282
Query: 334 ESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLE 393
++ EE ++ ++ +L E E +A++ + EI E + L+ E +R +LE
Sbjct: 283 QNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLE 342
Query: 394 DQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYK 453
Q++ + ++ + ++ Y++ ++++E R + + ++ +++ ++++L E++ Y+
Sbjct: 343 RQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYR 402
Query: 454 GCLE 457
LE
Sbjct: 403 KLLE 406
Score = 38.1 bits (87), Expect = 0.018
Identities = 69/384 (17%), Positives = 158/384 (41%), Gaps = 61/384 (15%)
Query: 135 HVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQ------ 188
H+ E + + + S + +R++ ++N+ + E + R+ + +A Q
Sbjct: 253 HITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAE-EWFKCRYAKLTEAAEQNKEAIR 311
Query: 189 -----LEEERDQLIHELVLLR---------EPALQEVQQVHQDILAAYKLHAQAELERDG 234
+ E R QL + + L E L ++++ H L++Y+ Q
Sbjct: 312 SAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQ------ 365
Query: 235 LREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDA 294
L E+R K ++ + +E YQ L + + A +R++L T+ S +
Sbjct: 366 LENELRGTKWEMARHLRE---YQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGP 422
Query: 295 YQKQKEQL-------RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQF 347
+ + + ++EAP + F++E E + + + ++EE
Sbjct: 423 LYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIE-----ETKVEDEKSEMEEALTAIT 477
Query: 348 LRLL-----ERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQK 402
L E+KEA + + +AE +E+ P++A A +++ + E++ ++
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 403 RDEE------------VQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
++E ++ + EE E+ + + + ++ + KE +++ +EE++
Sbjct: 538 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE-EKSEEVA 596
Query: 451 TYKGCLEIYGQICNPETAKNFLAK 474
T K L ++ PE AK+ + K
Sbjct: 597 T-KEELVADAKVEKPEKAKSPVPK 619
Score = 31.2 bits (69), Expect = 2.2
Identities = 39/163 (23%), Positives = 68/163 (41%), Gaps = 13/163 (7%)
Query: 73 VQETEKAEEALYIEEAMQP-DEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPT 131
++ET+ +E +EEA+ E L V +E +E + V P K T
Sbjct: 457 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 516
Query: 132 SPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIED--LELLEGRFQQCVQAVAQL 189
+PE EGE + EE +S EE S ++ E EG Q+ + A+
Sbjct: 517 APEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE-QEEGETEAEA 575
Query: 190 EEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELER 232
E E + E ++V++ +++ +L A A++E+
Sbjct: 576 EGEEAEAKEE---------KKVEEKSEEVATKEELVADAKVEK 609
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 79.3 bits (194), Expect = 7e-15
Identities = 70/328 (21%), Positives = 153/328 (46%), Gaps = 32/328 (9%)
Query: 149 SNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR---- 204
SN +S+R ++ +++ L RF ++ V +LE++ L EL++LR
Sbjct: 80 SNDLKSIRTQEKAQLQD---------LNDRFASFIERVHELEQQNKVLEAELLVLRQKHS 130
Query: 205 EPAL------QEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQY 258
EP+ QE++ + A + ER+GL E +R ++ + +E V +
Sbjct: 131 EPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARY----EEEVLSRE 186
Query: 259 QLECRQQDVAQFAD----FREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRD 314
E R + + AD R L R L +E++ L+ ++++ +L+ Q++ +
Sbjct: 187 DAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVE 246
Query: 315 GHFLQES-----RRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQ 369
+ + + AQ+E L A++ Q+ EE ++ +F L E T A++ + E+
Sbjct: 247 MDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVS 306
Query: 370 EMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQ 429
E + L+ E R N LE Q+ + K++ ++ ++ + ++E R ++ +
Sbjct: 307 ESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMA 366
Query: 430 LQQQKNKEMEQLRLSLAEELSTYKGCLE 457
++ +++ ++++L E++ Y+ LE
Sbjct: 367 RYLKEYQDLLNVKMALDIEIAAYRKLLE 394
Score = 33.1 bits (74), Expect = 0.57
Identities = 38/174 (21%), Positives = 68/174 (39%), Gaps = 35/174 (20%)
Query: 279 TRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQD 338
++ +S +L +R + Q + L + R F++ L Q + L AE
Sbjct: 74 SQVAAISNDLKSIRTQEKAQLQDL--------NDRFASFIERVHELEQQNKVLEAELLVL 125
Query: 339 LEEEYEPQFLRLLERKEA---------GTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
++ EP R L +E T Q Q E + ++E LR LQA + L
Sbjct: 126 RQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSR 185
Query: 390 RNLE----------DQIALVRQKRDEEVQQYREQL--------EEMEERQRQLR 425
+ E D+ AL R + ++ + +++ EE+ E Q Q++
Sbjct: 186 EDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQ 239
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 78.2 bits (191), Expect = 2e-14
Identities = 92/383 (24%), Positives = 173/383 (45%), Gaps = 31/383 (8%)
Query: 95 LHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEES 154
LH PGN T +E + +E G P P+ + E+ P+E
Sbjct: 2 LHQPTPGNRGLTARMEVGPATETFVLELQCLEDGGP-GPDTLSGGSGGSESQEEEEPQER 60
Query: 155 LRAEQSPSVEENLSIEDL--ELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
+ Q P+V + ++ E G+ + +Q + Q E + Q HE + +P L+ Q
Sbjct: 61 NSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQ 120
Query: 213 QVHQD---ILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQ 269
Q QD L+ + + L+ E++L+ Q+ ++ + V Q +L+ +QQ+ Q
Sbjct: 121 QPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQ-QLQPQQVQEQQRLQ-QQQEQLQ 178
Query: 270 FADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQ--LEAPPSQRDGHFLQESRRLSAQ 327
+E + + ++ Q + Q+Q+EQL+QQ L+ + F Q+ +L Q
Sbjct: 179 TQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQ 238
Query: 328 FENLMAESRQDLEEEYEPQFL-----RLLERKEAGTKAL----QRTQAEIQEMKEALRPL 378
+ L+ + + L+++ Q +LLE+++A + Q+ Q + Q+ ++ L+
Sbjct: 239 QQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQ 298
Query: 379 QAEARQLRLQNRNLE----DQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
Q + +Q +LQ LE +++ L D +Q EQ + ERQ++L ++
Sbjct: 299 QEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQEL--------ER 350
Query: 435 NKEMEQLRLSLAEELSTYKGCLE 457
+E QL+L L EEL + LE
Sbjct: 351 QQEQRQLQLKLQEELQQLEQQLE 373
Score = 68.6 bits (166), Expect = 1e-11
Identities = 98/406 (24%), Positives = 184/406 (45%), Gaps = 39/406 (9%)
Query: 61 LEDTGDLDETLYV----QETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPD 116
LED G +TL E+++ EE +E + V P E + E T P
Sbjct: 32 LEDGGPGPDTLSGGSGGSESQEEEEP---QERNSSPQRPAVSAPVGASE---IAEETRPG 85
Query: 117 R--IQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEES-------LRAEQSPSVEENL 167
+ +Q + +P P+H + + P++ L+ E+ SV
Sbjct: 86 QRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQE 145
Query: 168 SIEDLELLEGRFQ---QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKL 224
+L+L+ + Q Q VQ +L+++++QL + + LQ+ +Q+ Q + L
Sbjct: 146 LKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQ-EQQVLQQQEQLQQQVQEQQLL 204
Query: 225 HAQAE-LERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQ 283
Q E L++ L ++ ++Q+ F+ +E + Q QL QQ Q +++L + Q
Sbjct: 205 QQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQ---QGQLQQQLLQQQQAQ 261
Query: 284 LSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEY 343
L ++L + + A Q Q++ L QQ E Q+ LQ+ + Q + + EEE
Sbjct: 262 LQQQLLEQQQA-QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEV 320
Query: 344 EPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKR 403
E L L+ + L++ + E++ +E R Q E RQL+L+ L++++ + Q+
Sbjct: 321 E---LELMPVDLGSEQELEQQRQELERQQELER--QQEQRQLQLK---LQEELQQLEQQL 372
Query: 404 DEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+++ QQ +Q ++E +L G Q QQ+ E+ ++ L EL
Sbjct: 373 EQQQQQLEQQEVQLELTPVEL--GAQ-QQEVQLELTPVQPELQLEL 415
>gi|14917115 keratin 31 [Homo sapiens]
Length = 416
Score = 74.3 bits (181), Expect = 2e-13
Identities = 73/324 (22%), Positives = 144/324 (44%), Gaps = 44/324 (13%)
Query: 170 EDLELLEGRFQQCVQAVAQLEE---ERDQLIHELVLLREPAL--------QEVQQVHQDI 218
E ++ L R ++ V QLE E + LI E +EP L + ++++ Q I
Sbjct: 58 ETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKI 117
Query: 219 LAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLT 278
L +A+ ++ D + + K YQ +L RQ + R +L
Sbjct: 118 LCTKSENARLVVQIDNAKLAADDFRTK----------YQTELSLRQLVESDINGLRRILD 167
Query: 279 ----------TRATQLSEELAQLRDAYQKQKEQLRQQL--------EAPPSQRDGHFLQE 320
+ L EEL L+ ++++ LR QL +A P+ L E
Sbjct: 168 ELTLCKSDLEAQVESLKEELLCLKSNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNRVLNE 227
Query: 321 SRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQA 380
+R +Q+E L+ +R+++E+ + Q L ++ + ++ LQ QAEI E++ + L+
Sbjct: 228 TR---SQYEALVETNRREVEQWFTTQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEI 284
Query: 381 EARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQ 440
E + +LE+ + + ++ Q + + +E + ++R+ ++ Q Q+ + +
Sbjct: 285 ELQAQHNLRDSLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLD 344
Query: 441 LRLSLAEELSTYKGCLEIYGQICN 464
+R L E++TY+ LE + CN
Sbjct: 345 VRARLECEINTYRSLLE--SEDCN 366
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 73.9 bits (180), Expect = 3e-13
Identities = 71/307 (23%), Positives = 138/307 (44%), Gaps = 22/307 (7%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREP--ALQEVQQVHQ----------D 217
E ++ L +F + V LE++ L + LL++ A + + + +
Sbjct: 93 EQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLE 152
Query: 218 ILAAYKLHAQAEL-ERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV 276
L KL +AEL GL E+ K K + + + ++DV + +
Sbjct: 153 TLGQEKLKLEAELGNMQGLVEDF---KNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVE 209
Query: 277 LTTRATQLSEELAQLRDAYQKQKEQLRQQLE------APPSQRDGHFLQESRRLSAQFEN 330
L +R L++E+ LR Y+++ +L+ Q+ + + R + AQ+E+
Sbjct: 210 LESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYED 269
Query: 331 LMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR 390
+ SR + E Y+ ++ L L+RT+ EI EM + LQAE L+ Q
Sbjct: 270 IANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRA 329
Query: 391 NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
+LE IA Q+ + ++ +L E+E ++ + + Q ++ +E+ ++L+L E++
Sbjct: 330 SLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIA 389
Query: 451 TYKGCLE 457
TY+ LE
Sbjct: 390 TYRKLLE 396
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/312 (22%), Positives = 143/312 (45%), Gaps = 20/312 (6%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAE 229
E ++ L +F + V LE++ L + LL+E + V+Q + + +Y + +
Sbjct: 151 EQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQ 210
Query: 230 LE-----RDGLREEIRLVKQKL--FKVTKEC-----VAYQYQLECRQQDVAQFADFREVL 277
LE R L E+R ++ + FKV E A + + ++DV + L
Sbjct: 211 LESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVEL 270
Query: 278 TTRATQLSEELAQLRDAYQKQKEQLRQQLE------APPSQRDGHFLQESRRLSAQFENL 331
+ L EE+ + + + QL+ Q+ + + R+ + AQ+E++
Sbjct: 271 EAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDI 330
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
SR + E Y+ ++ L L+ T+ EI EM ++ L+AE ++ Q +
Sbjct: 331 ANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSS 390
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELST 451
L+ IA Q+ + ++ R +L ++EE ++ + + ++ +E+ ++L+L E++T
Sbjct: 391 LQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIAT 450
Query: 452 YKGCLEIYGQIC 463
Y+ LE G+ C
Sbjct: 451 YRKLLE--GEEC 460
>gi|28173564 keratin 73 [Homo sapiens]
Length = 540
Score = 73.2 bits (178), Expect = 5e-13
Identities = 74/316 (23%), Positives = 141/316 (44%), Gaps = 28/316 (8%)
Query: 170 EDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAE 229
E +++L +F + V LE++ L + LL++ L + + IL Y + + +
Sbjct: 134 EQIKVLNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQ 193
Query: 230 LE-----RDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQL 284
LE R L E+R V++ + K Y+ ++ R +F ++ + T
Sbjct: 194 LETLSGDRVRLDSELRSVREVVEDYKKR---YEEEINKRTTAENEFVVLKKDVDAAYTSK 250
Query: 285 SEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLS-----------------AQ 327
E A++ DA + + + E +Q H S LS AQ
Sbjct: 251 VELQAKV-DALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLDSIIAEVRAQ 309
Query: 328 FENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRL 387
+E + +S+ + E Y+ +F L L+ T+ EI E+ ++ L++E ++
Sbjct: 310 YEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRLRSEIESVKK 369
Query: 388 QNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAE 447
Q NLE IA Q+ D ++ R +L+E+E +Q + + ++ +E+ ++LSL
Sbjct: 370 QCANLETAIADAEQRGDCALKDARAKLDELEGALQQAKEELARMLREYQELLSVKLSLDI 429
Query: 448 ELSTYKGCLEIYGQIC 463
E++TY+ LE G+ C
Sbjct: 430 EIATYRKLLE--GEEC 443
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 73.2 bits (178), Expect = 5e-13
Identities = 109/482 (22%), Positives = 204/482 (42%), Gaps = 62/482 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1468 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1640
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1641 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1819 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1866
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKG 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 455 CL 456
L
Sbjct: 1927 KL 1928
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 904 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 963 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1005
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1066 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1122 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1234 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Score = 59.3 bits (142), Expect = 7e-09
Identities = 78/329 (23%), Positives = 145/329 (44%), Gaps = 47/329 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 923 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1037
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1038 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1067
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
++ + E+ + L EEL K LE
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELE 1156
Score = 47.4 bits (111), Expect = 3e-05
Identities = 74/356 (20%), Positives = 158/356 (44%), Gaps = 68/356 (19%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1353 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1402
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELS 450
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 16/123 (13%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 911 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 956
Query: 447 EEL 449
E+L
Sbjct: 957 EQL 959
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 863
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 73.2 bits (178), Expect = 5e-13
Identities = 109/482 (22%), Positives = 204/482 (42%), Gaps = 62/482 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1475 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1647
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1648 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1826 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1873
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKG 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 455 CL 456
L
Sbjct: 1934 KL 1935
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 911 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 970 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1012
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1073 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1129 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1241 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Score = 59.3 bits (142), Expect = 7e-09
Identities = 78/329 (23%), Positives = 145/329 (44%), Gaps = 47/329 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 930 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1044
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1045 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1074
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
++ + E+ + L EEL K LE
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELE 1163
Score = 47.4 bits (111), Expect = 3e-05
Identities = 74/356 (20%), Positives = 158/356 (44%), Gaps = 68/356 (19%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1360 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1409
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELS 450
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 16/123 (13%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 918 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 963
Query: 447 EEL 449
E+L
Sbjct: 964 EQL 966
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 870
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 73.2 bits (178), Expect = 5e-13
Identities = 109/482 (22%), Positives = 204/482 (42%), Gaps = 62/482 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1475 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1647
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1648 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1826 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1873
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKG 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 455 CL 456
L
Sbjct: 1934 KL 1935
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 911 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 970 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1012
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1073 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1129 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1241 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Score = 59.3 bits (142), Expect = 7e-09
Identities = 78/329 (23%), Positives = 145/329 (44%), Gaps = 47/329 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 930 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1044
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1045 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1074
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
++ + E+ + L EEL K LE
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELE 1163
Score = 47.4 bits (111), Expect = 3e-05
Identities = 74/356 (20%), Positives = 158/356 (44%), Gaps = 68/356 (19%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1360 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1409
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELS 450
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 16/123 (13%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 918 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 963
Query: 447 EEL 449
E+L
Sbjct: 964 EQL 966
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 811 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 870
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 73.2 bits (178), Expect = 5e-13
Identities = 109/482 (22%), Positives = 204/482 (42%), Gaps = 62/482 (12%)
Query: 16 AARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDL-----DET 70
A + R EA + K + +L+ A AL E L ++ L + + + DL D
Sbjct: 1468 ADERDRAEAEAR-EKETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 71 LYVQETEKAEEAL--YIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQF-----VEG 123
V E EK++ AL +EE E L E + + +E + + QF
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 124 PVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLEL-----LEGR 178
K + ++E ET E+ + +L A +E +L +DLEL ++GR
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDL--KDLELQADSAIKGR 1640
Query: 179 FQQCVQAVAQLEEERDQLIHELVLLREPALQ-----------------EVQQVHQDILAA 221
++ ++ + +L+ + EL R + ++ Q+ +D+ AA
Sbjct: 1641 -EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 222 YKLHAQAELERDGLREEI-------RLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFR 274
+ QA+LE++ L EE+ ++ + ++ + +LE Q ++ +D
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
T +A QLS ELA R QK E RQQLE + + + ++F++ +A
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLED 394
+ + E Q + K+A TK+L++ +++E+ LQ E R + +
Sbjct: 1819 LEAKIAQ-LEEQVEQEAREKQAATKSLKQKDKKLKEIL-----LQVE------DERKMAE 1866
Query: 395 QIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKG 454
Q +K + V+Q + QLEE EE +++ + Q++ E + ++ E++ K
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 455 CL 456
L
Sbjct: 1927 KL 1928
Score = 62.8 bits (151), Expect = 7e-10
Identities = 85/414 (20%), Positives = 187/414 (45%), Gaps = 40/414 (9%)
Query: 38 AEALNPEVTLSSEGSLNLEDILY-----LEDTGDLDETLYVQETEKAEEALYIEEAMQPD 92
AEA V L+++ LE+IL+ LE+ D + L + + A++ L +EE ++ +
Sbjct: 904 AEAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 93 EALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPE 152
EA + + +E+ T +I+ +E + V+ + E+ E
Sbjct: 963 EA--------ARQKLQLEKVTAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLE 1005
Query: 153 ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQ 212
E + + EE ++L L+ + + + + ++ ++ EL L+ +
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 213 QVHQDILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
H+ I L AQ AEL+ ++E L + L ++ E L+ ++ +
Sbjct: 1066 DFHEQIA---DLQAQIAELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHF--LQESRRLSAQFE 329
D +E L SE A R+ +KQK L ++LEA ++ + + L A+ E
Sbjct: 1122 DLQEDLD------SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 330 NLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQN 389
+ ++ L+EE ++ E ++ +A++ ++++ K A L + L +N
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 390 RNLEDQIALVRQKRDEEVQQYREQLE-EMEERQRQLRNGVQLQQQKNKEMEQLR 442
+L ++ ++ Q + +EV+ +++LE +++E Q + +G + + + N ++ +L+
Sbjct: 1234 ADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Score = 59.3 bits (142), Expect = 7e-09
Identities = 78/329 (23%), Positives = 145/329 (44%), Gaps = 47/329 (14%)
Query: 141 ETVTRAEKSNPE-ESLRAEQSPSVEE-NLSIEDLEL---LEGRFQQCVQAVAQLEEERDQ 195
+T R +K+ E + L + S EE NL E L+ L ++ +A ++E ++
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 196 LIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLF--KVTKEC 253
++HE+ E L+E + Q + A K AQ L+ + EE +QKL KVT E
Sbjct: 923 ILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978
Query: 254 VAYQYQLECRQQDVA--QFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPS 311
+ + E D + + R++L R + L+ LA+ + K +L+ + E+ S
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMIS 1037
Query: 312 QRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEM 371
+ + +E + SRQ+LE+ L+RK G + +
Sbjct: 1038 ELEVRLKKEEK------------SRQELEK---------LKRKLEG---------DASDF 1067
Query: 372 KEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYR---EQLEEMEERQRQLRNGV 428
E + LQA+ +L++Q E+++ + D+E+ Q +++ E+E L+ +
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
++ + E+ + L EEL K LE
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELE 1156
Score = 47.4 bits (111), Expect = 3e-05
Identities = 74/356 (20%), Positives = 158/356 (44%), Gaps = 68/356 (19%)
Query: 152 EESLRAEQSPSVEENLSIEDLELLEGR--FQQCVQAVAQLEEERDQLIHELVLLREPALQ 209
+E + A+Q+ +E ++S +++L + + Q V LEE + + E+ +
Sbjct: 1353 DEEMEAKQN--LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--------E 1402
Query: 210 EVQQVHQDILAAY----KLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
+ Q +++ AAY K + + E D L ++ +Q + + K+ + L +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 266 DVAQFADFREVLT-------TRATQLS---EELAQLRDAYQKQKEQLRQQLEAPPSQRDG 315
+++AD R+ T+A L+ EE + ++ ++ + L+ ++E S +D
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 316 -----HFLQESRR-LSAQFENLMAESRQDLEEEYEP-----------------QFLRLL- 351
H L++S+R L Q E + + ++LE+E + QF R L
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 352 ---ERKEAGTKALQRT----QAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
E+ E + LQR + E+++ ++ A ++L ++LE Q + R+
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 405 EEVQQYREQLEEMEERQRQLRNG----------VQLQQQKNKEMEQLRLSLAEELS 450
E ++Q R+ +M++ QR+L + + ++K K +E + L E+L+
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 16/123 (13%)
Query: 329 ENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE--IQEMKEALRPLQAEARQLR 386
E M +L++ E Q E KE K Q T+ + +QE +A L AEA ++R
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 387 LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLA 446
++ +A +Q+ +E + + +LEE E+R +QL Q + K+M Q L L
Sbjct: 911 VR-------LAAKKQELEEILHEMEARLEEEEDRGQQL-------QAERKKMAQQMLDLE 956
Query: 447 EEL 449
E+L
Sbjct: 957 EQL 959
Score = 35.0 bits (79), Expect = 0.15
Identities = 23/93 (24%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 359 KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQ--KRDEEVQQYREQLEE 416
KA + Q ++ MK R A + Q L ++ + Q +++EE+Q ++L++
Sbjct: 804 KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK 863
Query: 417 MEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
+ERQ++ N ++ +QK+ ++ + + L E+L
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
>gi|10337581 type I hair keratin 3B [Homo sapiens]
Length = 404
Score = 72.8 bits (177), Expect = 6e-13
Identities = 66/307 (21%), Positives = 139/307 (45%), Gaps = 22/307 (7%)
Query: 170 EDLELLEGRFQQCVQAVAQLEE---ERDQLIHELVLLREPAL--------QEVQQVHQDI 218
E ++ L R ++ V QLE E + LI E +EP L + ++++ Q I
Sbjct: 58 ETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKI 117
Query: 219 LAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLT 278
L + +A+ ++ D + + K + + ++ + + R L
Sbjct: 118 LCSKSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCRSDLE 177
Query: 279 TRATQLSEELAQLRDAYQKQKEQLRQQL--------EAPPSQRDGHFLQESRRLSAQFEN 330
+ L EEL L+ ++++ LR QL +A P+ L E+R Q+E
Sbjct: 178 AQMESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRN---QYEA 234
Query: 331 LMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR 390
L+ +R+++E+ + Q L ++ + ++ LQ QAEI E++ + L+ E +
Sbjct: 235 LVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLRY 294
Query: 391 NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
+LE+ + + ++ Q + + +E + ++R+ ++ Q Q+ + + +R L E++
Sbjct: 295 SLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEIN 354
Query: 451 TYKGCLE 457
TY+ LE
Sbjct: 355 TYRSLLE 361
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 72.4 bits (176), Expect = 8e-13
Identities = 84/359 (23%), Positives = 154/359 (42%), Gaps = 31/359 (8%)
Query: 127 PGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAV 186
PG P P + E VT + +L+ + S E ++ L +F + V
Sbjct: 130 PGFPVCPPGGIQE---VTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKV 186
Query: 187 AQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAEL-----ERDGLREEIRL 241
LE++ L + LL+E + V+Q + + Y + + +L ER L E+R
Sbjct: 187 RFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRN 246
Query: 242 VKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQ 301
+ Q L + K Y+ ++ R +F ++ + A EL DA +
Sbjct: 247 M-QDLVEDFKN--KYEDEINKRTTAENEFVMLKKDVDA-AYMNKVELEAKVDALMDEINF 302
Query: 302 LRQQLEAPPSQRDGHFLQESRRLS-----------------AQFENLMAESRQDLEEEYE 344
++ +A SQ H S LS AQ+E + SR + E Y+
Sbjct: 303 MKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQ 362
Query: 345 PQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRD 404
++ L + L+ T+ EI EM ++ L+AE ++ Q NL++ IA Q+ +
Sbjct: 363 TKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGE 422
Query: 405 EEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLEIYGQIC 463
++ R +L E+EE ++ + + ++ +E+ +L+L E++TY+ LE G+ C
Sbjct: 423 LALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLE--GEEC 479
>gi|14917117 keratin 33A [Homo sapiens]
Length = 404
Score = 71.6 bits (174), Expect = 1e-12
Identities = 69/317 (21%), Positives = 142/317 (44%), Gaps = 42/317 (13%)
Query: 170 EDLELLEGRFQQCVQAVAQLEE---ERDQLIHELVLLREPAL--------QEVQQVHQDI 218
E ++ L R ++ V QLE E + LI E +EP + + ++++ Q I
Sbjct: 58 ETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFKTIEELQQKI 117
Query: 219 LAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLT 278
L + +A+ ++ D + + K Y+ +L RQ + R +L
Sbjct: 118 LCSKSENARLVVQIDNAKLASDDFRTK----------YETELSLRQLVESDINGLRRILD 167
Query: 279 ----------TRATQLSEELAQLRDAYQKQKEQLRQQL--------EAPPSQRDGHFLQE 320
+ L EEL L+ ++++ LR QL +A P+ L E
Sbjct: 168 ELTLCRSDLEAQVESLKEELLCLKQNHEQEVNTLRCQLGDRLNVEVDAAPTVDLNQVLNE 227
Query: 321 SRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQA 380
+R +Q+E L+ +R+++E+ + Q L ++ + ++ LQ QAEI E++ + L+
Sbjct: 228 TR---SQYEALVETNRREVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEI 284
Query: 381 EARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQ 440
E + +LE+ + + ++ Q + + +E + ++R+ ++ Q Q+ + +
Sbjct: 285 ELQAQHNLRDSLENTLTESEARYSSQLSQVQRLITNVESQLAEIRSDLERQNQEYQVLLD 344
Query: 441 LRLSLAEELSTYKGCLE 457
+R L E++TY+ LE
Sbjct: 345 VRARLECEINTYRSLLE 361
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 71.6 bits (174), Expect = 1e-12
Identities = 115/507 (22%), Positives = 209/507 (41%), Gaps = 72/507 (14%)
Query: 12 GAAQAARKTRVEANSPLPKNSGSLNEAEALNPE--------VTLSSEGSLNLEDILYLE- 62
G Q + R EA + + E EAL E V EG E+ L
Sbjct: 845 GREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL 904
Query: 63 DTGDLDETLY-----VQETEKAEEALYIE--EAMQPDEALHVEEPGNPEETVCVEETTEP 115
+ L+ +L+ + + E E L E + E L E G ++ + +E
Sbjct: 905 EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASL 964
Query: 116 DRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIEDLELL 175
D+ + V+ + E + R +++ EE L+ Q E+ + +LE
Sbjct: 965 DKELMAQKLVQAER---------EAQASLREQRAAHEEDLQRLQR---EKEAAWRELEAE 1012
Query: 176 EGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQD----ILAAYKLHAQA--- 228
+ Q +QL+ E+++L+ L +E +E+ + Q+ +L A QA
Sbjct: 1013 RAQLQ------SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSL 1066
Query: 229 -ELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEE 287
E E+ L E++ + L ++ E + + RQ+ Q LT+ L +
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQE---QDRSTVNALTSELRDLRAQ 1123
Query: 288 LAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEY---- 343
+ A+ ++ +L++Q QRD L+E+ L Q L+ ++R L E
Sbjct: 1124 REEAAAAHAQEVRRLQEQARDLGKQRDS-CLREAEELRTQLR-LLEDARDGLRRELLEAQ 1181
Query: 344 ----EPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEAR-----------QLRLQ 388
E Q R ++R+EAG L+R+ E + +EALR E R L+L
Sbjct: 1182 RKLRESQEGREVQRQEAGE--LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
Query: 389 NRNLEDQIALVRQKR---DEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSL 445
N + E ++AL+ + R +E + R L+E+E + + R +Q +++ K ++ L
Sbjct: 1240 NEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRL 1299
Query: 446 AEELSTYKGCLEIYGQICNPETAKNFL 472
EL+ +G L + G+ E+ + L
Sbjct: 1300 GRELAELQGRLAL-GERAEKESRRETL 1325
Score = 60.5 bits (145), Expect = 3e-09
Identities = 74/300 (24%), Positives = 136/300 (45%), Gaps = 43/300 (14%)
Query: 196 LIHELVLLREPALQEVQ---QVHQDILAAYKLH-AQAELERDGLREEIRLVKQKLFKVTK 251
LIH + R+ +Q+++ + QD+L + + +E ER L E+++ ++ K +
Sbjct: 523 LIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQ 582
Query: 252 ECVAYQYQLECRQQDVAQFADFREVLTTR----------ATQLSEELAQLRDAYQKQKEQ 301
E Q++V + E+L+ A Q +EEL Q R+ Q +E+
Sbjct: 583 AH-------EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE 635
Query: 302 LRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKA- 360
LR+Q + +++ +Q+ R+ + E + Q LE + L+E +EA ++A
Sbjct: 636 LRRQRDRLEEEQEDA-VQDGARVRRELERSHRQLEQ-LEGKRSVLAKELVEVREALSRAT 693
Query: 361 LQRT--QAEIQEMKEALRPLQA-------EARQLRLQNRNLEDQIA--------LVRQKR 403
LQR QAE E+ EAL +A +LR + +L+D ++ L + K
Sbjct: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
Query: 404 DEE--VQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLEIYGQ 461
D V Q E+ ++ RQRQ + +++ + +E+LRL +G L + Q
Sbjct: 754 DLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQ 813
Score = 55.8 bits (133), Expect = 8e-08
Identities = 95/420 (22%), Positives = 167/420 (39%), Gaps = 54/420 (12%)
Query: 74 QETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSP 133
QE EK + A EE + + L E+ ++ V E Q + +E +
Sbjct: 624 QEREKLQAAQ--EELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQ--LEGKRSVLA 679
Query: 134 EHVVYEGETVTRA---------EKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCV- 183
+ +V E ++RA EK+ E+L ++ VE LS+ L E Q +
Sbjct: 680 KELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLS 739
Query: 184 -----------------QAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHA 226
+ VAQLEEE+ L + A QE ++ +L
Sbjct: 740 KLSALNESLAQDKLDLNRLVAQLEEEKSALQGR----QRQAEQEATVAREEQERLEELRL 795
Query: 227 QAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA---DFREVLTTRATQ 283
+ E+ R GL +R+ +Q + ++ +++ Q+ +AQ + RE +A +
Sbjct: 796 EQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
Query: 284 LSEELAQLRDAYQKQKEQLRQQ-----LEAPPSQRDGHFL-QESRRLSAQFENL---MAE 334
++ + + ++KE L ++ ++ ++R+G L +E+ RL + E L + E
Sbjct: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE 915
Query: 335 SRQDL------EEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQ 388
++ L E+ E + LL KE T L + +I +E L E +L
Sbjct: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS-LDKELMAQKLV 974
Query: 389 NRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEE 448
E Q +L Q+ E R Q E+ + QLQ Q +E E+L L E
Sbjct: 975 QAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAE 1034
Score = 55.1 bits (131), Expect = 1e-07
Identities = 78/309 (25%), Positives = 133/309 (43%), Gaps = 28/309 (9%)
Query: 156 RAEQSPSV--EENLSIEDLEL--------LEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
+AEQ +V EE +E+L L LEG + QA LE++ L HE L+E
Sbjct: 775 QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQE 834
Query: 206 PALQEVQQV--HQDILAAYKLHAQAELE--RDGLREEIRLVKQKLFKVTKECVAYQYQLE 261
Q +Q+ + L + AQ ++E RE+ L K+ + + VA + +
Sbjct: 835 QLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA-GLAVQLVAAEREGR 893
Query: 262 CRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQES 321
++ + +E L ++ +LAQL +A ++Q E Q L G
Sbjct: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQL-EARREQLEAEGQALLLAKETLTGELAGLR 952
Query: 322 RRLSAQFEN------LMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEAL 375
+++ A E LMA+ E E + L E++ A + LQR Q +E + A
Sbjct: 953 QQIIATQEKASLDKELMAQKLVQAEREAQAS---LREQRAAHEEDLQRLQ---REKEAAW 1006
Query: 376 RPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKN 435
R L+AE QL+ Q + ++++ + EE+ + L++ + L + Q
Sbjct: 1007 RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSL 1066
Query: 436 KEMEQLRLS 444
KE E+ LS
Sbjct: 1067 KESEKTALS 1075
Score = 51.2 bits (121), Expect = 2e-06
Identities = 80/322 (24%), Positives = 138/322 (42%), Gaps = 48/322 (14%)
Query: 154 SLRAEQSPSVEENLSIED-LELLEGRFQQCVQAVAQ--------------LEEERDQLIH 198
+LR + S S E ++E+ L+ L + +QA L E+ L H
Sbjct: 551 TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAH 610
Query: 199 ELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQY 258
L + ++ A +E++Q + + AA + + +RD L EE Q +V +E
Sbjct: 611 SLQVAQQQA-EELRQEREKLQAAQE---ELRRQRDRLEEEQEDAVQDGARVRRELERSHR 666
Query: 259 QLEC----RQQDVAQFADFREVLTTRATQ---LSEELAQLRDAYQKQKE-QLRQQLEAPP 310
QLE R + + RE L+ Q L E A++ +A K + ++ +L
Sbjct: 667 QLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTK 726
Query: 311 SQRDGHFLQES-RRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQ 369
+ + LQ+S +LSA E+L A+ + DL RL+ + E ALQ Q + +
Sbjct: 727 LRAEEASLQDSLSKLSALNESL-AQDKLDLN--------RLVAQLEEEKSALQGRQRQAE 777
Query: 370 EMKEALRPLQAEARQLRLQN----RNLEDQIALVRQKRDEEVQQY------REQL-EEME 418
+ R Q +LRL+ + LE + + Q ++ QQ R QL E++
Sbjct: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
Query: 419 ERQRQLRNGVQLQQQKNKEMEQ 440
+ RQL Q +Q +E ++
Sbjct: 838 QLSRQLSGREQELEQARREAQR 859
Score = 50.1 bits (118), Expect = 4e-06
Identities = 64/315 (20%), Positives = 141/315 (44%), Gaps = 29/315 (9%)
Query: 145 RAEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLR 204
+AE + EES+R + E +++ + LE Q + +E+ ++
Sbjct: 1578 QAELALQEESVRRSER---ERRATLDQVATLERSLQATESELRASQEKISKM-----KAN 1629
Query: 205 EPALQEVQQVHQDILAAYKLHA-QAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECR 263
E L+ ++ +++L A + + EL+R L E++ + L + A Q +++
Sbjct: 1630 ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSL 1689
Query: 264 QQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRR 323
Q+ VA L +L+ LA++ ++ ++++R EA Q S
Sbjct: 1690 QRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEA--------LAQSSAS 1741
Query: 324 LSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEAR 383
L++ + + + E++ Q L+ ER +A +AL + + + E ++ L+ E
Sbjct: 1742 LNSTRDKNLHLQKALTACEHDRQVLQ--ERLDAARQALSEARKQSSSLGEQVQTLRGEVA 1799
Query: 384 QLRLQNRNLEDQIA----LVRQKRDEE------VQQYREQLEEMEERQRQLRNGVQLQQQ 433
L LQ E Q+ ++RQ+++ E VQ+ +++ ++ER L+ + +
Sbjct: 1800 DLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEA 1859
Query: 434 KNKEMEQLRLSLAEE 448
+ +E+E+ L L ++
Sbjct: 1860 EKREVERSALRLEKD 1874
Score = 43.9 bits (102), Expect = 3e-04
Identities = 94/464 (20%), Positives = 182/464 (39%), Gaps = 93/464 (20%)
Query: 46 TLSSEGSLNLEDILYLEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPE- 104
TL+ E + + I+ ++ LD+ L Q+ +AE + +++ A H E+ +
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREA--QASLREQRAAHEEDLQRLQR 1000
Query: 105 ETVCVEETTEPDRIQFVE----------GPVEPGKPTSPEHVVY------EGETVTRAEK 148
E E +R Q +E K E + EG + +EK
Sbjct: 1001 EKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
Query: 149 SNP------EESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQL------ 196
E++ +E+ +L+ LE+ +Q A ++ E++R +
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEME----RQKRDAQSRQEQDRSTVNALTSE 1116
Query: 197 IHELVLLREPAL----QEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKE 252
+ +L RE A QEV+++ + K E + LR ++RL++ + +E
Sbjct: 1117 LRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRE 1176
Query: 253 CVAYQYQLECRQQDVAQFADFREVLTTRATQLSEEL---AQLRDAYQKQKEQLRQQLEAP 309
+ Q +L Q+ REV A +L L A+ R+A ++ E+LR ++
Sbjct: 1177 LLEAQRKLRESQEG-------REVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA 1229
Query: 310 PSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAE-- 367
ES R+S + N E + L EE + G + ++R++ E
Sbjct: 1230 ----------ESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEAR 1279
Query: 368 --IQEMKEALRPLQAEARQLRLQNRNLEDQIAL--------------------------- 398
+QE++ ++ L +E +L + L+ ++AL
Sbjct: 1280 RELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLE 1339
Query: 399 -VRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQL 441
+RQ+ ++ +EQ E R+R+L L++ + E +QL
Sbjct: 1340 VMRQELQVAQRKLQEQEGEFRTRERRLLG--SLEEARGTEKQQL 1381
Score = 43.9 bits (102), Expect = 3e-04
Identities = 64/257 (24%), Positives = 109/257 (42%), Gaps = 40/257 (15%)
Query: 148 KSNPE--ESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
+SN E +++ +S + L+ ED E Q +A LEE R + E LR
Sbjct: 1217 RSNEELRSAVKKAESERISLKLANEDKE----------QKLALLEEARTAVGKEAGELRT 1266
Query: 206 PALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
LQEV++ +L A+ EL+ LR +++++ + ++ +E Q +L ++
Sbjct: 1267 -GLQEVERS--------RLEARRELQE--LRRQMKMLDSENTRLGRELAELQGRLALGER 1315
Query: 266 DVAQFADFREVLTTRATQLSEE--LAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRR 323
A+ RE L R L E L +R Q + +L++Q +G F RR
Sbjct: 1316 --AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQ--------EGEFRTRERR 1365
Query: 324 LSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEAR 383
L E +Q L+ + R EA L+ + AE + L+AE
Sbjct: 1366 LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAE-----GRAQGLEAELA 1420
Query: 384 QLRLQNRNLEDQIALVR 400
++ +Q R E Q+ +R
Sbjct: 1421 RVEVQRRAAEAQLGGLR 1437
Score = 41.2 bits (95), Expect = 0.002
Identities = 67/282 (23%), Positives = 132/282 (46%), Gaps = 53/282 (18%)
Query: 175 LEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDIL-AAYKLHAQAELERD 233
+ G + Q+ A L RD+ +H L A + +QV Q+ L AA + ++A +
Sbjct: 1728 VRGLTEALAQSSASLNSTRDKNLHLQKALT--ACEHDRQVLQERLDAARQALSEARKQSS 1785
Query: 234 GLREEIRLVKQKLFKVTKECVAYQYQLE-----CRQQD---------VAQFADFREVLTT 279
L E+++ ++ ++ + + V + QL+ RQ+ V + D R +L
Sbjct: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE 1845
Query: 280 RATQLSEELAQL--------RDAYQKQKEQ--LRQQLEAPPSQR-DGHFLQESRRLSAQF 328
R L LAQL R A + +K++ LR+ L+ ++ H +++ RLSA+
Sbjct: 1846 RLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSH--EDTVRLSAEK 1903
Query: 329 ENL----------MAESRQDLEEEYEPQFLRLLERKEAGTKA---LQRTQAEIQEMKEAL 375
L +AE+++ +++ E Q + +LE+ + + Q+ Q E+Q+ E L
Sbjct: 1904 GRLDRTLTGAELELAEAQRQIQQ-LEAQVV-VLEQSHSPAQLEVDAQQQQLELQQEVERL 1961
Query: 376 RPLQAEA--------RQLRLQNRNLEDQIALVRQKRDEEVQQ 409
R QA+ R R + R LE+Q++ ++ + +E+++
Sbjct: 1962 RSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRR 2003
Score = 39.3 bits (90), Expect = 0.008
Identities = 39/135 (28%), Positives = 67/135 (49%), Gaps = 16/135 (11%)
Query: 318 LQESRRLSAQ----FENLMAESRQDLEE---EYEPQFLRLLE--RKEAGTKALQRTQAEI 368
LQE +L Q E+L+A+SR + +E +Y RL + R E G Q + +
Sbjct: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
Query: 369 QEMKEALRPLQAEA----RQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQL 424
++ E R LQ E R+L+ + Q LV Q+ ++ QY+++ E+E Q+ L
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLV-QRLQGKILQYKKRCSELE--QQLL 195
Query: 425 RNGVQLQQQKNKEME 439
+L+QQ+ ++ E
Sbjct: 196 ERSGELEQQRLRDTE 210
Score = 39.3 bits (90), Expect = 0.008
Identities = 107/491 (21%), Positives = 184/491 (37%), Gaps = 59/491 (12%)
Query: 14 AQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEG--SLNLEDILYLEDTGDLDETL 71
AQ R+ + +A + L EAE L ++ L + L E + + E
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191
Query: 72 YVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFV---------- 121
VQ E E + E + EAL EE + E +RI
Sbjct: 1192 EVQRQEAGELRRSLGEGAKEREALRRSN----EELRSAVKKAESERISLKLANEDKEQKL 1247
Query: 122 ----EGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSI-EDLELLE 176
E GK + +R E + LR + EN + +L L+
Sbjct: 1248 ALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQ 1307
Query: 177 GRFQQCVQAVAQLEEERDQL-IHELVLLREPALQEVQQVHQDILAAYKLHAQA------E 229
GR + A+ E R+ L + + +L E +L+ ++Q Q +A KL Q E
Sbjct: 1308 GRL--ALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQ--VAQRKLQEQEGEFRTRE 1363
Query: 230 LERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELA 289
G EE R +++ + + +LE + + A+ RA L ELA
Sbjct: 1364 RRLLGSLEEARGTEKQQLDHAR---GLELKLEAARAEAAELGLRLSAAEGRAQGLEAELA 1420
Query: 290 QL---RDAYQKQKEQLRQQLE-------AP---PSQRDGHFLQESRRLSAQFENLMAESR 336
++ R A + Q LR L AP P G +++ E L + S
Sbjct: 1421 RVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPA-EGSGEGLNSPST 1479
Query: 337 QDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQI 396
+ +P + + + ++E + LR Q E +LR Q L Q+
Sbjct: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQL 1539
Query: 397 ALVRQKRD---EEVQQYREQLEEMEERQRQL---RNGVQ----LQQQKNKEMEQLRLSLA 446
A + +RD +Q ++ + E EE +R + +GVQ LQ++ + E+ R +
Sbjct: 1540 AEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATL 1599
Query: 447 EELSTYKGCLE 457
++++T + L+
Sbjct: 1600 DQVATLERSLQ 1610
Score = 38.5 bits (88), Expect = 0.013
Identities = 85/376 (22%), Positives = 151/376 (40%), Gaps = 51/376 (13%)
Query: 100 PGNPEETVCVEETTE----PDRIQFVEG--PVEPGKPTSPEHVVYEGETVTRAEKSNPEE 153
PG+P E + E P ++ G P PG TSP + E V A + +E
Sbjct: 1458 PGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQE 1517
Query: 154 SLRAE--------QSPSVEENLSIEDLEL--LEGRFQQCVQAVAQLEEERDQLIHELVLL 203
A+ Q+ ++ L+ + E R +Q +AVA+ EE R + L +
Sbjct: 1518 LRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
Query: 204 R-EPALQE--VQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQL 260
+ E ALQE V++ ++ A A E E+R ++K+ K+ A + +L
Sbjct: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMK----ANETKL 1633
Query: 261 ECRQQDVAQFADFREVLTTRAT----QLSEELAQLR----------DAYQKQKEQLRQQL 306
E ++ + + D E T + L EL + R A Q + + L++Q+
Sbjct: 1634 EGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693
Query: 307 EAPPSQRDGHFLQESRRLSA------QFENLMAESRQDLEEEYEPQFLRLLERKEAGT-- 358
A + G RL+ + E + + + L E L ++
Sbjct: 1694 -ADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHL 1752
Query: 359 -KALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEM 417
KAL + + Q ++E L + + R Q+ +L +Q+ +R EV Q E
Sbjct: 1753 QKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRG----EVADLELQRVEA 1808
Query: 418 EERQRQLRNGVQLQQQ 433
E + +QLR ++ +Q+
Sbjct: 1809 EGQLQQLREVLRQRQE 1824
Score = 37.7 bits (86), Expect = 0.023
Identities = 25/88 (28%), Positives = 46/88 (52%), Gaps = 2/88 (2%)
Query: 374 ALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQ 433
+L LQ E + L+ + +ED +A R +RDE +Y E +E+ R ++ Q+
Sbjct: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
Query: 434 KN--KEMEQLRLSLAEELSTYKGCLEIY 459
+ ++ +LR L EE ++Y+ L+ Y
Sbjct: 135 RGLVRQSVELRRQLQEEQASYRRKLQAY 162
Score = 32.0 bits (71), Expect = 1.3
Identities = 30/144 (20%), Positives = 66/144 (45%), Gaps = 2/144 (1%)
Query: 146 AEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
AEK E S + V +++ +E + R + ++ + D+ + L
Sbjct: 1859 AEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELA 1918
Query: 206 PALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQ 265
A +++QQ+ ++ + H+ A+LE D ++++ L +Q++ ++ + LE R++
Sbjct: 1919 EAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-QQEVERLRSAQAQTERTLEARER 1977
Query: 266 DVAQ-FADFREVLTTRATQLSEEL 288
Q E ++T QL +EL
Sbjct: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
>gi|131412228 keratin 13 isoform b [Homo sapiens]
Length = 420
Score = 71.6 bits (174), Expect = 1e-12
Identities = 69/323 (21%), Positives = 141/323 (43%), Gaps = 46/323 (14%)
Query: 165 ENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQE---------VQQVH 215
E +++++L + + V+A+ + + + I + L + PA E ++++
Sbjct: 104 EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELR 163
Query: 216 QDILAAYKLHAQAELERDGLR---EEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFAD 272
IL A + + LE D R ++ RL Y+ +L RQ A
Sbjct: 164 DKILTATIENNRVILEIDNARLAADDFRL-------------KYENELALRQSVEADING 210
Query: 273 FREVLTT----------RATQLSEELAQLRDAYQKQKEQLRQQ--------LEAPPSQRD 314
R VL + L+EELA ++ ++++ ++ Q ++A P
Sbjct: 211 LRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDL 270
Query: 315 GHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
L E R Q+E + +R+D EE + + L + T +Q ++ EI E++
Sbjct: 271 TRVLAEMRE---QYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRT 327
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+ E + LE+ +A + ++QQ + + +E + +LR+ ++ Q Q+
Sbjct: 328 LQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQE 387
Query: 435 NKEMEQLRLSLAEELSTYKGCLE 457
K + ++ L +E++TY+ LE
Sbjct: 388 YKMLLDIKTRLEQEIATYRSLLE 410
>gi|131412225 keratin 13 isoform a [Homo sapiens]
Length = 458
Score = 71.6 bits (174), Expect = 1e-12
Identities = 69/323 (21%), Positives = 141/323 (43%), Gaps = 46/323 (14%)
Query: 165 ENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQE---------VQQVH 215
E +++++L + + V+A+ + + + I + L + PA E ++++
Sbjct: 104 EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELR 163
Query: 216 QDILAAYKLHAQAELERDGLR---EEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFAD 272
IL A + + LE D R ++ RL Y+ +L RQ A
Sbjct: 164 DKILTATIENNRVILEIDNARLAADDFRL-------------KYENELALRQSVEADING 210
Query: 273 FREVLTT----------RATQLSEELAQLRDAYQKQKEQLRQQ--------LEAPPSQRD 314
R VL + L+EELA ++ ++++ ++ Q ++A P
Sbjct: 211 LRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDL 270
Query: 315 GHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
L E R Q+E + +R+D EE + + L + T +Q ++ EI E++
Sbjct: 271 TRVLAEMRE---QYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRT 327
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+ E + LE+ +A + ++QQ + + +E + +LR+ ++ Q Q+
Sbjct: 328 LQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQE 387
Query: 435 NKEMEQLRLSLAEELSTYKGCLE 457
K + ++ L +E++TY+ LE
Sbjct: 388 YKMLLDIKTRLEQEIATYRSLLE 410
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 71.6 bits (174), Expect = 1e-12
Identities = 124/501 (24%), Positives = 202/501 (40%), Gaps = 61/501 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYL 61
A+ R G +G QA R EA + + + EAE L +V S+ E L
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 62 EDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPD----- 116
+ + Q +A E L ++ A + + L E + ET +
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQ-AEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 117 ---RIQFVEGPVEPGKPTSPEHVVY---EGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
R F E + + EHV E RA++ E R E +E ++
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER-WQLK 1637
Query: 171 DLELLEGRFQ------QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKL 224
E L R Q Q A A+ E+++++ E R E Q V Q LA +L
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELAEQEL 1694
Query: 225 HAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQL 284
Q +L +G ++ +Q+L ++ E + Q + ++++A+ T + +L
Sbjct: 1695 EKQRQLA-EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 285 SEELAQLR--------------DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFEN 330
ELA++R + + E+ +Q+LEA R +E+ RL A E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEE 1812
Query: 331 LMAESRQDLEEEYEPQFL---RLLERKEA--GTKALQRTQAEIQEMKEALRPLQAEARQL 385
+ RQ EE+ Q R+L K A G +T+AEI AL+ +AE +L
Sbjct: 1813 AKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI-----ALKEKEAENERL 1866
Query: 386 R-------LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEM 438
R Q R LE+Q A + +E + Q R+ + ERQ+ L L+Q++ E
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT-LRQRRQVEE 1925
Query: 439 EQLRLSLA-EELSTYKGCLEI 458
E L L + E+ + K LE+
Sbjct: 1926 EILALKASFEKAAAGKAELEL 1946
Score = 66.2 bits (160), Expect = 6e-11
Identities = 65/278 (23%), Positives = 126/278 (45%), Gaps = 43/278 (15%)
Query: 152 EESLRAEQSPSVEENLSIEDLEL-------LEGRFQQCVQAVAQLEEERDQLIHELVLLR 204
+ +L AE+ +E + E L+L + R ++ Q + EE + +H L
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 205 EPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQ 264
+ + VQ + Q++ + + LRE I ++++ K+ +E Q + E
Sbjct: 2425 QEKVTLVQTLEIQ-------RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE--- 2474
Query: 265 QDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRL 324
E+ T + QL +E L+ ++ +K+ L Q R+ QE +L
Sbjct: 2475 ----------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ--------RERFIEQEKAKL 2516
Query: 325 SAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQ 384
F++ +A+++Q L EE + Q ++ + ++ +++ + E +E +R Q E +Q
Sbjct: 2517 EQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 385 LRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQR 422
L Q R E+ +A EE Q+ REQL+ +EE+ R
Sbjct: 2576 LEQQRRQQEELLA-------EENQRLREQLQLLEEQHR 2606
Score = 63.5 bits (153), Expect = 4e-10
Identities = 101/446 (22%), Positives = 184/446 (41%), Gaps = 72/446 (16%)
Query: 54 NLEDILYLEDTGDLDET----LYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCV 109
N ED L ++ +L+ L +E + EA EE +Q ++L EE + +
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQ--KSLAAEEEAARQRKAAL 2008
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSP-------- 161
EE ++ ++ VE + E E + + ++ L+AE+
Sbjct: 2009 EE------VERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 162 --SVEENLSIED--LELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQD 217
+++ L E L+ L G + +A + EE R Q E R ++E +++ Q
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-VEEAERLKQS 2120
Query: 218 ILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVL 277
+ AQA+ + LR+E +Q+ + + A Q + ++ + F E
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKE---AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 278 TTRATQLSEELAQLR---DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
+ Q+ +EL LR + QK L ++L+ ++ E+ R +Q E +
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-----EAARQRSQVEEELFS 2232
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKAL-----QRTQAEIQEMKEALRPLQAEARQLRLQN 389
R +EE +L R EA +AL TQ +QE E ++ + EA +L +
Sbjct: 2233 VRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 390 RNLEDQIALVRQKRDEEVQQYR--------EQLEEMEERQRQLRNGVQLQQQKN------ 435
+ + A +RQ +E++ Q R E+++ ++E R LQQQK
Sbjct: 2288 Q----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 436 ----KEMEQLRLSLAEELSTYKGCLE 457
++ EQ+ LAEE ++ LE
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLE 2369
Score = 62.4 bits (150), Expect = 9e-10
Identities = 99/460 (21%), Positives = 200/460 (43%), Gaps = 40/460 (8%)
Query: 5 EPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPE--VTLSSEGSLNLEDILYLE 62
E +R A + A + R EA L + ++ EA L E + L + + N E
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 63 DTGDLDETLYVQETE-KAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFV 121
D L Q + KA+ + + + ++ + G E+T+ E + I +
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE-EEILAL 1930
Query: 122 EGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVE----ENLSIEDLELLEG 177
+ E E + G +SN E++LR+++ +E L+ E+
Sbjct: 1931 KASFEKAAAGKAELELELGRI-----RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 178 RFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE 237
++ +++A EE Q R+ AL+EV+++ + A +L +AE E +
Sbjct: 1986 AEERVQKSLAAEEEAARQ--------RKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 238 EIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQK 297
+ QK + ++ A+ + ++ ++Q++ Q + + + +E A R A +
Sbjct: 2038 LAQEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE--AARRAAEEA 2093
Query: 298 QKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAG 357
++ +++ + EA S+R ++E+ RL E A++R + E RKEA
Sbjct: 2094 EEARVQAEREAAQSRRQ---VEEAERLKQSAEE-QAQARAQAQAAAEKL------RKEAE 2143
Query: 358 TKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEM 417
+A +R QAE + ALR QA ++ +++ +Q + + ++E+ R QLEE
Sbjct: 2144 QEAARRAQAE----QAALRQKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 418 EERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
+ ++ L +Q + + E + R + EEL + + +E
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Score = 62.0 bits (149), Expect = 1e-09
Identities = 60/297 (20%), Positives = 139/297 (46%), Gaps = 16/297 (5%)
Query: 153 ESLRAEQSPSVEENLSIE-DLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEV 211
E + E+ +V+E ++ + ELL+ + + + +L+E+++Q+ +L E
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA--------EE 2360
Query: 212 QQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
Q Q L A + Q E+ + R ++R+ + + E A +++ + +++ +
Sbjct: 2361 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA--EEIGEKL 2417
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENL 331
E+ T L + L R E+LR+ + +++ QE++ L + E +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEM 2476
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
++ L +E + L K++ + + + E ++++ + A+A+QLR + +
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEE 448
+ Q+ RQ+ +++ R + E EE R+ + +Q +Q+ ++ E+L LAEE
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL---LAEE 2590
Score = 60.8 bits (146), Expect = 3e-09
Identities = 80/352 (22%), Positives = 153/352 (43%), Gaps = 53/352 (15%)
Query: 139 EGETVTRAEKSNPEESLR--AEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQL 196
E + +K N + L+ AE+ V E + R Q A+L + ++
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---------RLSVAAQEAARLRQLAEED 2300
Query: 197 IHELVLLREPALQEVQQVHQDILAAYKLHAQAEL---ERDGLREEIRLVK----QKLFKV 249
+ + L E L+E Q Q+ A +L A+AEL +++ +E+ R ++ Q ++
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQE---ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 250 TKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRD---AYQKQKEQL---- 302
+E +Q LE +Q + + E L R ++S A+ + ++KQ E++
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 303 -RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEP--QFLRLLERKEAGTK 359
R +L L+ R+ S + E+ +LE E E Q +LL+ K +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 360 ALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLE-----------DQIALVRQKRDEEVQ 408
+Q+ Q +QE + + +E L + R +E D++A +Q R+E+ +
Sbjct: 2478 TVQQEQL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 409 QYREQ----------LEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
Q ++ +EE RQ + GV+ +Q++ +++EQ R E L+
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588
Score = 60.5 bits (145), Expect = 3e-09
Identities = 97/384 (25%), Positives = 172/384 (44%), Gaps = 59/384 (15%)
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP---EESLRAEQSP--SVE 164
+ E +R+ VE +E + + H + + A++ EE +R E++ + +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 165 ENLSI-EDLELLEGRFQQCVQAVAQLEE--ERDQLIHE----LVLLREPALQEVQQVHQD 217
+ SI E+L+ L + +QA A+ E ER +L E +V L+ A + + +
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 218 ILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV 276
L A + A+ AE ++ +EE +++++ ++ + +L R + A+ A ++
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ- 1532
Query: 277 LTTRATQLSEELA--------QLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQF 328
RA Q EEL +LR A ++ Q++ LE +QR +S+R S
Sbjct: 1533 ---RALQALEELRLQAEEAERRLRQAEVERARQVQVALET--AQRSAEAELQSKRAS--- 1584
Query: 329 ENLMAESRQDLEEEYEPQFLRLLE-RKEAGTKALQRTQAEIQEMKEALRPLQA------E 381
AE LE + + + + + R+EA +A Q+ +AE + +EA R L+ E
Sbjct: 1585 ---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELERWQLKANE 1640
Query: 382 ARQLRLQNRNLEDQIALV-----------------RQKRDEEVQQYREQLEEMEERQRQL 424
A +LRLQ + Q +L R K +E+ + RE E+ E+QRQL
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 425 RNGVQLQQQKNKEMEQLRLSLAEE 448
G QQ+ E E +RL E
Sbjct: 1701 AEGT-AQQRLAAEQELIRLRAETE 1723
Score = 55.5 bits (132), Expect = 1e-07
Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 25/303 (8%)
Query: 156 RAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVH 215
RAE+ S + LE GRF++ + A+L ++ + L E A + Q+
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR--QRAE 1830
Query: 216 QDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVA-QFADFR 274
+ + A KL A E R EI L KE A +L +D A Q
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIAL---------KEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
E + E LAQLR A + E+ + +E QR +E L A FE A
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAG 1940
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR---- 390
+ E E + R+ R A + QAE++ ++ + E R+ + R
Sbjct: 1941 -----KAELELELGRI--RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 391 -NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
E++ A R+ EEV++ + ++EE + + Q Q +E Q RL E+
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 450 STY 452
+
Sbjct: 2054 HAF 2056
Score = 54.3 bits (129), Expect = 2e-07
Identities = 63/313 (20%), Positives = 137/313 (43%), Gaps = 15/313 (4%)
Query: 146 AEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
A+ E LR EQ+ E E +E + +Q + A+ E + +L +
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 206 PALQ-EVQQVHQDILAAYKLHAQAELERDGLREE-IRLVKQKLFKVTKECVAYQYQLECR 263
PA + +VQ + ++ Y E L + I+ + + L ++ +E + Q
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 264 QQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFL---QE 320
++ +A+ E + QL+E AQ + +++ ++L+Q+++ +R+ + Q+
Sbjct: 1359 RERLAEV----EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 321 SRRLSAQFENLMAESRQDLE------EEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
R + + + L S +++ E E LR+ E L+ T+ + +
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+A A + Q R +++ +R++ +E Q+ R+ E+ R + + +Q+
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 435 NKEMEQLRLSLAE 447
+ +E+LRL E
Sbjct: 1535 LQALEELRLQAEE 1547
Score = 53.5 bits (127), Expect = 4e-07
Identities = 112/509 (22%), Positives = 191/509 (37%), Gaps = 65/509 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAE---ALNPEVTL-----SSEGSL 53
A E R A QA + R++A + L +AE A +V L S+E L
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 54 NLEDILYLEDTGDLDETL---YVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVE 110
+ + E T L+ +L +V + EEA A Q EA E E
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAE--RRAQQQAEAERAREEAERELERWQL 1636
Query: 111 ETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
+ E R++ V K + + E R + + +A + + E +
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 171 DLELLEGRFQQCVQAVAQL----------EEERDQLIHELVLLREPALQEVQQ------- 213
+L EG QQ + A +L E++R L EL L+ A Q+
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 214 -----VHQDILAAYKLHAQAELERDGLREEIRLVKQ--KLFKVTKECVAYQY-------Q 259
++L A K A+ E + + RL + + ++ +E + Q
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 260 LECRQQDVA-QFADFREVLTTR------ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQ 312
+ ++D A Q A+ VL + AT+L E + + E+LR+ E Q
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 313 RDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMK 372
R +++ + A E +A+ R+ + E E Q + E + ++ + EI +K
Sbjct: 1877 RR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALK 1931
Query: 373 EALRPLQAEARQLRLQ----NRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGV 428
+ A +L L+ N ED + Q E +Q R+ E E R+R+ V
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERV 1990
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
Q +E + R + EE+ K +E
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Score = 45.8 bits (107), Expect = 8e-05
Identities = 110/485 (22%), Positives = 189/485 (38%), Gaps = 75/485 (15%)
Query: 10 GDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDE 69
G G A+ + + P P + +E E+TL + +YLE +
Sbjct: 1037 GKGVARLSAEAEKVLALPEPSPAAPTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTI-- 1091
Query: 70 TLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGK 129
+L ++ T+ AEE L E Q EA V P E + + + R Q E +
Sbjct: 1092 SLVIRGTQGAEEVLRAHEE-QLKEAQAV--PATLPELEATKASLKKLRAQ-----AEAQQ 1143
Query: 130 PTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LELLEGRFQQCVQ 184
PT R E +E Q E ++ +E +LLE R+Q +
Sbjct: 1144 PTFD---------ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE-RWQAVLA 1193
Query: 185 AVAQLEEERDQLIHELVLLREPA------LQEVQQVHQDILAAYKLHAQA---------- 228
+ E +QL +L RE A LQ+ ++ + I A +QA
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1253
Query: 229 ---ELERDGLREEI--RLVKQKLFKVTK---ECVAYQYQLECRQQDVAQFADFREVLTTR 280
E+ER G + E R KQ + + + V Y+ QLE VA A +V +
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE----PVASPAKKPKV-QSG 1308
Query: 281 ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLE 340
+ + +E LR Y + Q ++ F+ E+ R + E L + R +
Sbjct: 1309 SESVIQEYVDLRTHYSELTTLTSQYIK---------FISETLRRMEEEERLAEQQRAEER 1359
Query: 341 EEY-EPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAE-------ARQLRLQNRNL 392
E E + +R+ A A + QAE +E KE + +Q E A + Q R++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 393 EDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTY 452
++++ +RQ + E+Q Q E E + ++ +++ + + + E+ R EL
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 453 KGCLE 457
+ E
Sbjct: 1479 RARAE 1483
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 71.6 bits (174), Expect = 1e-12
Identities = 124/501 (24%), Positives = 202/501 (40%), Gaps = 61/501 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYL 61
A+ R G +G QA R EA + + + EAE L +V S+ E L
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523
Query: 62 EDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPD----- 116
+ + Q +A E L ++ A + + L E + ET +
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQ-AEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 117 ---RIQFVEGPVEPGKPTSPEHVVY---EGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
R F E + + EHV E RA++ E R E +E ++
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER-WQLK 1641
Query: 171 DLELLEGRFQ------QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKL 224
E L R Q Q A A+ E+++++ E R E Q V Q LA +L
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELAEQEL 1698
Query: 225 HAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQL 284
Q +L +G ++ +Q+L ++ E + Q + ++++A+ T + +L
Sbjct: 1699 EKQRQLA-EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 285 SEELAQLR--------------DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFEN 330
ELA++R + + E+ +Q+LEA R +E+ RL A E
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEE 1816
Query: 331 LMAESRQDLEEEYEPQFL---RLLERKEA--GTKALQRTQAEIQEMKEALRPLQAEARQL 385
+ RQ EE+ Q R+L K A G +T+AEI AL+ +AE +L
Sbjct: 1817 AKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI-----ALKEKEAENERL 1870
Query: 386 R-------LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEM 438
R Q R LE+Q A + +E + Q R+ + ERQ+ L L+Q++ E
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT-LRQRRQVEE 1929
Query: 439 EQLRLSLA-EELSTYKGCLEI 458
E L L + E+ + K LE+
Sbjct: 1930 EILALKASFEKAAAGKAELEL 1950
Score = 66.2 bits (160), Expect = 6e-11
Identities = 65/278 (23%), Positives = 126/278 (45%), Gaps = 43/278 (15%)
Query: 152 EESLRAEQSPSVEENLSIEDLEL-------LEGRFQQCVQAVAQLEEERDQLIHELVLLR 204
+ +L AE+ +E + E L+L + R ++ Q + EE + +H L
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428
Query: 205 EPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQ 264
+ + VQ + Q++ + + LRE I ++++ K+ +E Q + E
Sbjct: 2429 QEKVTLVQTLEIQ-------RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE--- 2478
Query: 265 QDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRL 324
E+ T + QL +E L+ ++ +K+ L Q R+ QE +L
Sbjct: 2479 ----------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ--------RERFIEQEKAKL 2520
Query: 325 SAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQ 384
F++ +A+++Q L EE + Q ++ + ++ +++ + E +E +R Q E +Q
Sbjct: 2521 EQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Query: 385 LRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQR 422
L Q R E+ +A EE Q+ REQL+ +EE+ R
Sbjct: 2580 LEQQRRQQEELLA-------EENQRLREQLQLLEEQHR 2610
Score = 63.5 bits (153), Expect = 4e-10
Identities = 101/446 (22%), Positives = 184/446 (41%), Gaps = 72/446 (16%)
Query: 54 NLEDILYLEDTGDLDET----LYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCV 109
N ED L ++ +L+ L +E + EA EE +Q ++L EE + +
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQ--KSLAAEEEAARQRKAAL 2012
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSP-------- 161
EE ++ ++ VE + E E + + ++ L+AE+
Sbjct: 2013 EE------VERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 162 --SVEENLSIED--LELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQD 217
+++ L E L+ L G + +A + EE R Q E R ++E +++ Q
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-VEEAERLKQS 2124
Query: 218 ILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVL 277
+ AQA+ + LR+E +Q+ + + A Q + ++ + F E
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKE---AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Query: 278 TTRATQLSEELAQLR---DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
+ Q+ +EL LR + QK L ++L+ ++ E+ R +Q E +
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-----EAARQRSQVEEELFS 2236
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKAL-----QRTQAEIQEMKEALRPLQAEARQLRLQN 389
R +EE +L R EA +AL TQ +QE E ++ + EA +L +
Sbjct: 2237 VRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 390 RNLEDQIALVRQKRDEEVQQYR--------EQLEEMEERQRQLRNGVQLQQQKN------ 435
+ + A +RQ +E++ Q R E+++ ++E R LQQQK
Sbjct: 2292 Q----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347
Query: 436 ----KEMEQLRLSLAEELSTYKGCLE 457
++ EQ+ LAEE ++ LE
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLE 2373
Score = 62.4 bits (150), Expect = 9e-10
Identities = 99/460 (21%), Positives = 200/460 (43%), Gaps = 40/460 (8%)
Query: 5 EPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPE--VTLSSEGSLNLEDILYLE 62
E +R A + A + R EA L + ++ EA L E + L + + N E
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1875
Query: 63 DTGDLDETLYVQETE-KAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFV 121
D L Q + KA+ + + + ++ + G E+T+ E + I +
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE-EEILAL 1934
Query: 122 EGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVE----ENLSIEDLELLEG 177
+ E E + G +SN E++LR+++ +E L+ E+
Sbjct: 1935 KASFEKAAAGKAELELELGRI-----RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989
Query: 178 RFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE 237
++ +++A EE Q R+ AL+EV+++ + A +L +AE E +
Sbjct: 1990 AEERVQKSLAAEEEAARQ--------RKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 238 EIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQK 297
+ QK + ++ A+ + ++ ++Q++ Q + + + +E A R A +
Sbjct: 2042 LAQEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE--AARRAAEEA 2097
Query: 298 QKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAG 357
++ +++ + EA S+R ++E+ RL E A++R + E RKEA
Sbjct: 2098 EEARVQAEREAAQSRRQ---VEEAERLKQSAEE-QAQARAQAQAAAEKL------RKEAE 2147
Query: 358 TKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEM 417
+A +R QAE + ALR QA ++ +++ +Q + + ++E+ R QLEE
Sbjct: 2148 QEAARRAQAE----QAALRQKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
Query: 418 EERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
+ ++ L +Q + + E + R + EEL + + +E
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242
Score = 62.0 bits (149), Expect = 1e-09
Identities = 60/297 (20%), Positives = 139/297 (46%), Gaps = 16/297 (5%)
Query: 153 ESLRAEQSPSVEENLSIE-DLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEV 211
E + E+ +V+E ++ + ELL+ + + + +L+E+++Q+ +L E
Sbjct: 2313 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA--------EE 2364
Query: 212 QQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
Q Q L A + Q E+ + R ++R+ + + E A +++ + +++ +
Sbjct: 2365 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA--EEIGEKL 2421
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENL 331
E+ T L + L R E+LR+ + +++ QE++ L + E +
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEM 2480
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
++ L +E + L K++ + + + E ++++ + A+A+QLR + +
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEE 448
+ Q+ RQ+ +++ R + E EE R+ + +Q +Q+ ++ E+L LAEE
Sbjct: 2541 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL---LAEE 2594
Score = 60.8 bits (146), Expect = 3e-09
Identities = 80/352 (22%), Positives = 153/352 (43%), Gaps = 53/352 (15%)
Query: 139 EGETVTRAEKSNPEESLR--AEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQL 196
E + +K N + L+ AE+ V E + R Q A+L + ++
Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---------RLSVAAQEAARLRQLAEED 2304
Query: 197 IHELVLLREPALQEVQQVHQDILAAYKLHAQAEL---ERDGLREEIRLVK----QKLFKV 249
+ + L E L+E Q Q+ A +L A+AEL +++ +E+ R ++ Q ++
Sbjct: 2305 LAQQRALAEKMLKEKMQAVQE---ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 250 TKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRD---AYQKQKEQL---- 302
+E +Q LE +Q + + E L R ++S A+ + ++KQ E++
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 303 -RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEP--QFLRLLERKEAGTK 359
R +L L+ R+ S + E+ +LE E E Q +LL+ K +
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2481
Query: 360 ALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLE-----------DQIALVRQKRDEEVQ 408
+Q+ Q +QE + + +E L + R +E D++A +Q R+E+ +
Sbjct: 2482 TVQQEQL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 409 QYREQ----------LEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
Q ++ +EE RQ + GV+ +Q++ +++EQ R E L+
Sbjct: 2541 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2592
Score = 60.5 bits (145), Expect = 3e-09
Identities = 97/384 (25%), Positives = 172/384 (44%), Gaps = 59/384 (15%)
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP---EESLRAEQSP--SVE 164
+ E +R+ VE +E + + H + + A++ EE +R E++ + +
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1417
Query: 165 ENLSI-EDLELLEGRFQQCVQAVAQLEE--ERDQLIHE----LVLLREPALQEVQQVHQD 217
+ SI E+L+ L + +QA A+ E ER +L E +V L+ A + + +
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477
Query: 218 ILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV 276
L A + A+ AE ++ +EE +++++ ++ + +L R + A+ A ++
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ- 1536
Query: 277 LTTRATQLSEELA--------QLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQF 328
RA Q EEL +LR A ++ Q++ LE +QR +S+R S
Sbjct: 1537 ---RALQALEELRLQAEEAERRLRQAEVERARQVQVALET--AQRSAEAELQSKRAS--- 1588
Query: 329 ENLMAESRQDLEEEYEPQFLRLLE-RKEAGTKALQRTQAEIQEMKEALRPLQA------E 381
AE LE + + + + + R+EA +A Q+ +AE + +EA R L+ E
Sbjct: 1589 ---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELERWQLKANE 1644
Query: 382 ARQLRLQNRNLEDQIALV-----------------RQKRDEEVQQYREQLEEMEERQRQL 424
A +LRLQ + Q +L R K +E+ + RE E+ E+QRQL
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Query: 425 RNGVQLQQQKNKEMEQLRLSLAEE 448
G QQ+ E E +RL E
Sbjct: 1705 AEGT-AQQRLAAEQELIRLRAETE 1727
Score = 55.5 bits (132), Expect = 1e-07
Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 25/303 (8%)
Query: 156 RAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVH 215
RAE+ S + LE GRF++ + A+L ++ + L E A + Q+
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR--QRAE 1834
Query: 216 QDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVA-QFADFR 274
+ + A KL A E R EI L KE A +L +D A Q
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIAL---------KEKEAENERLRRLAEDEAFQRRRLE 1885
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
E + E LAQLR A + E+ + +E QR +E L A FE A
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAG 1944
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR---- 390
+ E E + R+ R A + QAE++ ++ + E R+ + R
Sbjct: 1945 -----KAELELELGRI--RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 391 -NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
E++ A R+ EEV++ + ++EE + + Q Q +E Q RL E+
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2057
Query: 450 STY 452
+
Sbjct: 2058 HAF 2060
Score = 54.3 bits (129), Expect = 2e-07
Identities = 63/313 (20%), Positives = 137/313 (43%), Gaps = 15/313 (4%)
Query: 146 AEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
A+ E LR EQ+ E E +E + +Q + A+ E + +L +
Sbjct: 1243 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1302
Query: 206 PALQ-EVQQVHQDILAAYKLHAQAELERDGLREE-IRLVKQKLFKVTKECVAYQYQLECR 263
PA + +VQ + ++ Y E L + I+ + + L ++ +E + Q
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 264 QQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFL---QE 320
++ +A+ E + QL+E AQ + +++ ++L+Q+++ +R+ + Q+
Sbjct: 1363 RERLAEV----EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1418
Query: 321 SRRLSAQFENLMAESRQDLE------EEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
R + + + L S +++ E E LR+ E L+ T+ + +
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+A A + Q R +++ +R++ +E Q+ R+ E+ R + + +Q+
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538
Query: 435 NKEMEQLRLSLAE 447
+ +E+LRL E
Sbjct: 1539 LQALEELRLQAEE 1551
Score = 53.5 bits (127), Expect = 4e-07
Identities = 112/509 (22%), Positives = 191/509 (37%), Gaps = 65/509 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAE---ALNPEVTL-----SSEGSL 53
A E R A QA + R++A + L +AE A +V L S+E L
Sbjct: 1527 AEAEAAREKQRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 54 NLEDILYLEDTGDLDETL---YVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVE 110
+ + E T L+ +L +V + EEA A Q EA E E
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAE--RRAQQQAEAERAREEAERELERWQL 1640
Query: 111 ETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
+ E R++ V K + + E R + + +A + + E +
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1700
Query: 171 DLELLEGRFQQCVQAVAQL----------EEERDQLIHELVLLREPALQEVQQ------- 213
+L EG QQ + A +L E++R L EL L+ A Q+
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760
Query: 214 -----VHQDILAAYKLHAQAELERDGLREEIRLVKQ--KLFKVTKECVAYQY-------Q 259
++L A K A+ E + + RL + + ++ +E + Q
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 260 LECRQQDVA-QFADFREVLTTR------ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQ 312
+ ++D A Q A+ VL + AT+L E + + E+LR+ E Q
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 313 RDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMK 372
R +++ + A E +A+ R+ + E E Q + E + ++ + EI +K
Sbjct: 1881 RR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALK 1935
Query: 373 EALRPLQAEARQLRLQ----NRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGV 428
+ A +L L+ N ED + Q E +Q R+ E E R+R+ V
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERV 1994
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
Q +E + R + EE+ K +E
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVE 2023
Score = 45.8 bits (107), Expect = 8e-05
Identities = 110/485 (22%), Positives = 189/485 (38%), Gaps = 75/485 (15%)
Query: 10 GDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDE 69
G G A+ + + P P + +E E+TL + +YLE +
Sbjct: 1041 GKGVARLSAEAEKVLALPEPSPAAPTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTI-- 1095
Query: 70 TLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGK 129
+L ++ T+ AEE L E Q EA V P E + + + R Q E +
Sbjct: 1096 SLVIRGTQGAEEVLRAHEE-QLKEAQAV--PATLPELEATKASLKKLRAQ-----AEAQQ 1147
Query: 130 PTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LELLEGRFQQCVQ 184
PT R E +E Q E ++ +E +LLE R+Q +
Sbjct: 1148 PTFD---------ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE-RWQAVLA 1197
Query: 185 AVAQLEEERDQLIHELVLLREPA------LQEVQQVHQDILAAYKLHAQA---------- 228
+ E +QL +L RE A LQ+ ++ + I A +QA
Sbjct: 1198 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1257
Query: 229 ---ELERDGLREEI--RLVKQKLFKVTK---ECVAYQYQLECRQQDVAQFADFREVLTTR 280
E+ER G + E R KQ + + + V Y+ QLE VA A +V +
Sbjct: 1258 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE----PVASPAKKPKV-QSG 1312
Query: 281 ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLE 340
+ + +E LR Y + Q ++ F+ E+ R + E L + R +
Sbjct: 1313 SESVIQEYVDLRTHYSELTTLTSQYIK---------FISETLRRMEEEERLAEQQRAEER 1363
Query: 341 EEY-EPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAE-------ARQLRLQNRNL 392
E E + +R+ A A + QAE +E KE + +Q E A + Q R++
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 393 EDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTY 452
++++ +RQ + E+Q Q E E + ++ +++ + + + E+ R EL
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 453 KGCLE 457
+ E
Sbjct: 1483 RARAE 1487
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 71.6 bits (174), Expect = 1e-12
Identities = 124/501 (24%), Positives = 202/501 (40%), Gaps = 61/501 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYL 61
A+ R G +G QA R EA + + + EAE L +V S+ E L
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 62 EDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPD----- 116
+ + Q +A E L ++ A + + L E + ET +
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQ-AEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 117 ---RIQFVEGPVEPGKPTSPEHVVY---EGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
R F E + + EHV E RA++ E R E +E ++
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER-WQLK 1637
Query: 171 DLELLEGRFQ------QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKL 224
E L R Q Q A A+ E+++++ E R E Q V Q LA +L
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELAEQEL 1694
Query: 225 HAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQL 284
Q +L +G ++ +Q+L ++ E + Q + ++++A+ T + +L
Sbjct: 1695 EKQRQLA-EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 285 SEELAQLR--------------DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFEN 330
ELA++R + + E+ +Q+LEA R +E+ RL A E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEE 1812
Query: 331 LMAESRQDLEEEYEPQFL---RLLERKEA--GTKALQRTQAEIQEMKEALRPLQAEARQL 385
+ RQ EE+ Q R+L K A G +T+AEI AL+ +AE +L
Sbjct: 1813 AKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI-----ALKEKEAENERL 1866
Query: 386 R-------LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEM 438
R Q R LE+Q A + +E + Q R+ + ERQ+ L L+Q++ E
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT-LRQRRQVEE 1925
Query: 439 EQLRLSLA-EELSTYKGCLEI 458
E L L + E+ + K LE+
Sbjct: 1926 EILALKASFEKAAAGKAELEL 1946
Score = 66.2 bits (160), Expect = 6e-11
Identities = 65/278 (23%), Positives = 126/278 (45%), Gaps = 43/278 (15%)
Query: 152 EESLRAEQSPSVEENLSIEDLEL-------LEGRFQQCVQAVAQLEEERDQLIHELVLLR 204
+ +L AE+ +E + E L+L + R ++ Q + EE + +H L
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 205 EPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQ 264
+ + VQ + Q++ + + LRE I ++++ K+ +E Q + E
Sbjct: 2425 QEKVTLVQTLEIQ-------RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE--- 2474
Query: 265 QDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRL 324
E+ T + QL +E L+ ++ +K+ L Q R+ QE +L
Sbjct: 2475 ----------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ--------RERFIEQEKAKL 2516
Query: 325 SAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQ 384
F++ +A+++Q L EE + Q ++ + ++ +++ + E +E +R Q E +Q
Sbjct: 2517 EQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 385 LRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQR 422
L Q R E+ +A EE Q+ REQL+ +EE+ R
Sbjct: 2576 LEQQRRQQEELLA-------EENQRLREQLQLLEEQHR 2606
Score = 63.5 bits (153), Expect = 4e-10
Identities = 101/446 (22%), Positives = 184/446 (41%), Gaps = 72/446 (16%)
Query: 54 NLEDILYLEDTGDLDET----LYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCV 109
N ED L ++ +L+ L +E + EA EE +Q ++L EE + +
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQ--KSLAAEEEAARQRKAAL 2008
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSP-------- 161
EE ++ ++ VE + E E + + ++ L+AE+
Sbjct: 2009 EE------VERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 162 --SVEENLSIED--LELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQD 217
+++ L E L+ L G + +A + EE R Q E R ++E +++ Q
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-VEEAERLKQS 2120
Query: 218 ILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVL 277
+ AQA+ + LR+E +Q+ + + A Q + ++ + F E
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKE---AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 278 TTRATQLSEELAQLR---DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
+ Q+ +EL LR + QK L ++L+ ++ E+ R +Q E +
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-----EAARQRSQVEEELFS 2232
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKAL-----QRTQAEIQEMKEALRPLQAEARQLRLQN 389
R +EE +L R EA +AL TQ +QE E ++ + EA +L +
Sbjct: 2233 VRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 390 RNLEDQIALVRQKRDEEVQQYR--------EQLEEMEERQRQLRNGVQLQQQKN------ 435
+ + A +RQ +E++ Q R E+++ ++E R LQQQK
Sbjct: 2288 Q----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 436 ----KEMEQLRLSLAEELSTYKGCLE 457
++ EQ+ LAEE ++ LE
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLE 2369
Score = 62.4 bits (150), Expect = 9e-10
Identities = 99/460 (21%), Positives = 200/460 (43%), Gaps = 40/460 (8%)
Query: 5 EPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPE--VTLSSEGSLNLEDILYLE 62
E +R A + A + R EA L + ++ EA L E + L + + N E
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 63 DTGDLDETLYVQETE-KAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFV 121
D L Q + KA+ + + + ++ + G E+T+ E + I +
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE-EEILAL 1930
Query: 122 EGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVE----ENLSIEDLELLEG 177
+ E E + G +SN E++LR+++ +E L+ E+
Sbjct: 1931 KASFEKAAAGKAELELELGRI-----RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 178 RFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE 237
++ +++A EE Q R+ AL+EV+++ + A +L +AE E +
Sbjct: 1986 AEERVQKSLAAEEEAARQ--------RKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 238 EIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQK 297
+ QK + ++ A+ + ++ ++Q++ Q + + + +E A R A +
Sbjct: 2038 LAQEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE--AARRAAEEA 2093
Query: 298 QKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAG 357
++ +++ + EA S+R ++E+ RL E A++R + E RKEA
Sbjct: 2094 EEARVQAEREAAQSRRQ---VEEAERLKQSAEE-QAQARAQAQAAAEKL------RKEAE 2143
Query: 358 TKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEM 417
+A +R QAE + ALR QA ++ +++ +Q + + ++E+ R QLEE
Sbjct: 2144 QEAARRAQAE----QAALRQKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 418 EERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
+ ++ L +Q + + E + R + EEL + + +E
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Score = 62.0 bits (149), Expect = 1e-09
Identities = 60/297 (20%), Positives = 139/297 (46%), Gaps = 16/297 (5%)
Query: 153 ESLRAEQSPSVEENLSIE-DLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEV 211
E + E+ +V+E ++ + ELL+ + + + +L+E+++Q+ +L E
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA--------EE 2360
Query: 212 QQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
Q Q L A + Q E+ + R ++R+ + + E A +++ + +++ +
Sbjct: 2361 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA--EEIGEKL 2417
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENL 331
E+ T L + L R E+LR+ + +++ QE++ L + E +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEM 2476
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
++ L +E + L K++ + + + E ++++ + A+A+QLR + +
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEE 448
+ Q+ RQ+ +++ R + E EE R+ + +Q +Q+ ++ E+L LAEE
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL---LAEE 2590
Score = 60.8 bits (146), Expect = 3e-09
Identities = 80/352 (22%), Positives = 153/352 (43%), Gaps = 53/352 (15%)
Query: 139 EGETVTRAEKSNPEESLR--AEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQL 196
E + +K N + L+ AE+ V E + R Q A+L + ++
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---------RLSVAAQEAARLRQLAEED 2300
Query: 197 IHELVLLREPALQEVQQVHQDILAAYKLHAQAEL---ERDGLREEIRLVK----QKLFKV 249
+ + L E L+E Q Q+ A +L A+AEL +++ +E+ R ++ Q ++
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQE---ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 250 TKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRD---AYQKQKEQL---- 302
+E +Q LE +Q + + E L R ++S A+ + ++KQ E++
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 303 -RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEP--QFLRLLERKEAGTK 359
R +L L+ R+ S + E+ +LE E E Q +LL+ K +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 360 ALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLE-----------DQIALVRQKRDEEVQ 408
+Q+ Q +QE + + +E L + R +E D++A +Q R+E+ +
Sbjct: 2478 TVQQEQL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 409 QYREQ----------LEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
Q ++ +EE RQ + GV+ +Q++ +++EQ R E L+
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2588
Score = 60.5 bits (145), Expect = 3e-09
Identities = 97/384 (25%), Positives = 172/384 (44%), Gaps = 59/384 (15%)
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP---EESLRAEQSP--SVE 164
+ E +R+ VE +E + + H + + A++ EE +R E++ + +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 165 ENLSI-EDLELLEGRFQQCVQAVAQLEE--ERDQLIHE----LVLLREPALQEVQQVHQD 217
+ SI E+L+ L + +QA A+ E ER +L E +V L+ A + + +
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 218 ILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV 276
L A + A+ AE ++ +EE +++++ ++ + +L R + A+ A ++
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ- 1532
Query: 277 LTTRATQLSEELA--------QLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQF 328
RA Q EEL +LR A ++ Q++ LE +QR +S+R S
Sbjct: 1533 ---RALQALEELRLQAEEAERRLRQAEVERARQVQVALET--AQRSAEAELQSKRAS--- 1584
Query: 329 ENLMAESRQDLEEEYEPQFLRLLE-RKEAGTKALQRTQAEIQEMKEALRPLQA------E 381
AE LE + + + + + R+EA +A Q+ +AE + +EA R L+ E
Sbjct: 1585 ---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELERWQLKANE 1640
Query: 382 ARQLRLQNRNLEDQIALV-----------------RQKRDEEVQQYREQLEEMEERQRQL 424
A +LRLQ + Q +L R K +E+ + RE E+ E+QRQL
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 425 RNGVQLQQQKNKEMEQLRLSLAEE 448
G QQ+ E E +RL E
Sbjct: 1701 AEGT-AQQRLAAEQELIRLRAETE 1723
Score = 55.5 bits (132), Expect = 1e-07
Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 25/303 (8%)
Query: 156 RAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVH 215
RAE+ S + LE GRF++ + A+L ++ + L E A + Q+
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR--QRAE 1830
Query: 216 QDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVA-QFADFR 274
+ + A KL A E R EI L KE A +L +D A Q
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIAL---------KEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
E + E LAQLR A + E+ + +E QR +E L A FE A
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAG 1940
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR---- 390
+ E E + R+ R A + QAE++ ++ + E R+ + R
Sbjct: 1941 -----KAELELELGRI--RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 391 -NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
E++ A R+ EEV++ + ++EE + + Q Q +E Q RL E+
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 450 STY 452
+
Sbjct: 2054 HAF 2056
Score = 54.3 bits (129), Expect = 2e-07
Identities = 63/313 (20%), Positives = 137/313 (43%), Gaps = 15/313 (4%)
Query: 146 AEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
A+ E LR EQ+ E E +E + +Q + A+ E + +L +
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 206 PALQ-EVQQVHQDILAAYKLHAQAELERDGLREE-IRLVKQKLFKVTKECVAYQYQLECR 263
PA + +VQ + ++ Y E L + I+ + + L ++ +E + Q
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 264 QQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFL---QE 320
++ +A+ E + QL+E AQ + +++ ++L+Q+++ +R+ + Q+
Sbjct: 1359 RERLAEV----EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 321 SRRLSAQFENLMAESRQDLE------EEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
R + + + L S +++ E E LR+ E L+ T+ + +
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+A A + Q R +++ +R++ +E Q+ R+ E+ R + + +Q+
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 435 NKEMEQLRLSLAE 447
+ +E+LRL E
Sbjct: 1535 LQALEELRLQAEE 1547
Score = 53.5 bits (127), Expect = 4e-07
Identities = 112/509 (22%), Positives = 191/509 (37%), Gaps = 65/509 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAE---ALNPEVTL-----SSEGSL 53
A E R A QA + R++A + L +AE A +V L S+E L
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 54 NLEDILYLEDTGDLDETL---YVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVE 110
+ + E T L+ +L +V + EEA A Q EA E E
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAE--RRAQQQAEAERAREEAERELERWQL 1636
Query: 111 ETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
+ E R++ V K + + E R + + +A + + E +
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 171 DLELLEGRFQQCVQAVAQL----------EEERDQLIHELVLLREPALQEVQQ------- 213
+L EG QQ + A +L E++R L EL L+ A Q+
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 214 -----VHQDILAAYKLHAQAELERDGLREEIRLVKQ--KLFKVTKECVAYQY-------Q 259
++L A K A+ E + + RL + + ++ +E + Q
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 260 LECRQQDVA-QFADFREVLTTR------ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQ 312
+ ++D A Q A+ VL + AT+L E + + E+LR+ E Q
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 313 RDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMK 372
R +++ + A E +A+ R+ + E E Q + E + ++ + EI +K
Sbjct: 1877 RR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALK 1931
Query: 373 EALRPLQAEARQLRLQ----NRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGV 428
+ A +L L+ N ED + Q E +Q R+ E E R+R+ V
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERV 1990
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
Q +E + R + EE+ K +E
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Score = 45.8 bits (107), Expect = 8e-05
Identities = 110/485 (22%), Positives = 189/485 (38%), Gaps = 75/485 (15%)
Query: 10 GDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDE 69
G G A+ + + P P + +E E+TL + +YLE +
Sbjct: 1037 GKGVARLSAEAEKVLALPEPSPAAPTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTI-- 1091
Query: 70 TLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGK 129
+L ++ T+ AEE L E Q EA V P E + + + R Q E +
Sbjct: 1092 SLVIRGTQGAEEVLRAHEE-QLKEAQAV--PATLPELEATKASLKKLRAQ-----AEAQQ 1143
Query: 130 PTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LELLEGRFQQCVQ 184
PT R E +E Q E ++ +E +LLE R+Q +
Sbjct: 1144 PTFD---------ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE-RWQAVLA 1193
Query: 185 AVAQLEEERDQLIHELVLLREPA------LQEVQQVHQDILAAYKLHAQA---------- 228
+ E +QL +L RE A LQ+ ++ + I A +QA
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1253
Query: 229 ---ELERDGLREEI--RLVKQKLFKVTK---ECVAYQYQLECRQQDVAQFADFREVLTTR 280
E+ER G + E R KQ + + + V Y+ QLE VA A +V +
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE----PVASPAKKPKV-QSG 1308
Query: 281 ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLE 340
+ + +E LR Y + Q ++ F+ E+ R + E L + R +
Sbjct: 1309 SESVIQEYVDLRTHYSELTTLTSQYIK---------FISETLRRMEEEERLAEQQRAEER 1359
Query: 341 EEY-EPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAE-------ARQLRLQNRNL 392
E E + +R+ A A + QAE +E KE + +Q E A + Q R++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 393 EDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTY 452
++++ +RQ + E+Q Q E E + ++ +++ + + + E+ R EL
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 453 KGCLE 457
+ E
Sbjct: 1479 RARAE 1483
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 71.6 bits (174), Expect = 1e-12
Identities = 124/501 (24%), Positives = 202/501 (40%), Gaps = 61/501 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYL 61
A+ R G +G QA R EA + + + EAE L +V S+ E L
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1487
Query: 62 EDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPD----- 116
+ + Q +A E L ++ A + + L E + ET +
Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQ-AEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 117 ---RIQFVEGPVEPGKPTSPEHVVY---EGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
R F E + + EHV E RA++ E R E +E ++
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER-WQLK 1605
Query: 171 DLELLEGRFQ------QCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKL 224
E L R Q Q A A+ E+++++ E R E Q V Q LA +L
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELAEQEL 1662
Query: 225 HAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQL 284
Q +L +G ++ +Q+L ++ E + Q + ++++A+ T + +L
Sbjct: 1663 EKQRQLA-EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 285 SEELAQLR--------------DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFEN 330
ELA++R + + E+ +Q+LEA R +E+ RL A E
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRALAEE 1780
Query: 331 LMAESRQDLEEEYEPQFL---RLLERKEA--GTKALQRTQAEIQEMKEALRPLQAEARQL 385
+ RQ EE+ Q R+L K A G +T+AEI AL+ +AE +L
Sbjct: 1781 AKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI-----ALKEKEAENERL 1834
Query: 386 R-------LQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEM 438
R Q R LE+Q A + +E + Q R+ + ERQ+ L L+Q++ E
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT-LRQRRQVEE 1893
Query: 439 EQLRLSLA-EELSTYKGCLEI 458
E L L + E+ + K LE+
Sbjct: 1894 EILALKASFEKAAAGKAELEL 1914
Score = 66.2 bits (160), Expect = 6e-11
Identities = 65/278 (23%), Positives = 126/278 (45%), Gaps = 43/278 (15%)
Query: 152 EESLRAEQSPSVEENLSIEDLEL-------LEGRFQQCVQAVAQLEEERDQLIHELVLLR 204
+ +L AE+ +E + E L+L + R ++ Q + EE + +H L
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392
Query: 205 EPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQ 264
+ + VQ + Q++ + + LRE I ++++ K+ +E Q + E
Sbjct: 2393 QEKVTLVQTLEIQ-------RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE--- 2442
Query: 265 QDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRL 324
E+ T + QL +E L+ ++ +K+ L Q R+ QE +L
Sbjct: 2443 ----------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ--------RERFIEQEKAKL 2484
Query: 325 SAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQ 384
F++ +A+++Q L EE + Q ++ + ++ +++ + E +E +R Q E +Q
Sbjct: 2485 EQLFQDEVAKAQQ-LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543
Query: 385 LRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQR 422
L Q R E+ +A EE Q+ REQL+ +EE+ R
Sbjct: 2544 LEQQRRQQEELLA-------EENQRLREQLQLLEEQHR 2574
Score = 63.5 bits (153), Expect = 4e-10
Identities = 101/446 (22%), Positives = 184/446 (41%), Gaps = 72/446 (16%)
Query: 54 NLEDILYLEDTGDLDET----LYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCV 109
N ED L ++ +L+ L +E + EA EE +Q ++L EE + +
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQ--KSLAAEEEAARQRKAAL 1976
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSP-------- 161
EE ++ ++ VE + E E + + ++ L+AE+
Sbjct: 1977 EE------VERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 162 --SVEENLSIED--LELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQD 217
+++ L E L+ L G + +A + EE R Q E R ++E +++ Q
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-VEEAERLKQS 2088
Query: 218 ILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVL 277
+ AQA+ + LR+E +Q+ + + A Q + ++ + F E
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKE---AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Query: 278 TTRATQLSEELAQLR---DAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
+ Q+ +EL LR + QK L ++L+ ++ E+ R +Q E +
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-----EAARQRSQVEEELFS 2200
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKAL-----QRTQAEIQEMKEALRPLQAEARQLRLQN 389
R +EE +L R EA +AL TQ +QE E ++ + EA +L +
Sbjct: 2201 VRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 390 RNLEDQIALVRQKRDEEVQQYR--------EQLEEMEERQRQLRNGVQLQQQKN------ 435
+ + A +RQ +E++ Q R E+++ ++E R LQQQK
Sbjct: 2256 Q----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311
Query: 436 ----KEMEQLRLSLAEELSTYKGCLE 457
++ EQ+ LAEE ++ LE
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLE 2337
Score = 62.4 bits (150), Expect = 9e-10
Identities = 99/460 (21%), Positives = 200/460 (43%), Gaps = 40/460 (8%)
Query: 5 EPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPE--VTLSSEGSLNLEDILYLE 62
E +R A + A + R EA L + ++ EA L E + L + + N E
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1839
Query: 63 DTGDLDETLYVQETE-KAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFV 121
D L Q + KA+ + + + ++ + G E+T+ E + I +
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE-EEILAL 1898
Query: 122 EGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVE----ENLSIEDLELLEG 177
+ E E + G +SN E++LR+++ +E L+ E+
Sbjct: 1899 KASFEKAAAGKAELELELGRI-----RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953
Query: 178 RFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLRE 237
++ +++A EE Q R+ AL+EV+++ + A +L +AE E +
Sbjct: 1954 AEERVQKSLAAEEEAARQ--------RKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005
Query: 238 EIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQK 297
+ QK + ++ A+ + ++ ++Q++ Q + + + +E A R A +
Sbjct: 2006 LAQEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE--AARRAAEEA 2061
Query: 298 QKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAG 357
++ +++ + EA S+R ++E+ RL E A++R + E RKEA
Sbjct: 2062 EEARVQAEREAAQSRRQ---VEEAERLKQSAEE-QAQARAQAQAAAEKL------RKEAE 2111
Query: 358 TKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEM 417
+A +R QAE + ALR QA ++ +++ +Q + + ++E+ R QLEE
Sbjct: 2112 QEAARRAQAE----QAALRQKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
Query: 418 EERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
+ ++ L +Q + + E + R + EEL + + +E
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206
Score = 62.0 bits (149), Expect = 1e-09
Identities = 60/297 (20%), Positives = 139/297 (46%), Gaps = 16/297 (5%)
Query: 153 ESLRAEQSPSVEENLSIE-DLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEV 211
E + E+ +V+E ++ + ELL+ + + + +L+E+++Q+ +L E
Sbjct: 2277 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA--------EE 2328
Query: 212 QQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFA 271
Q Q L A + Q E+ + R ++R+ + + E A +++ + +++ +
Sbjct: 2329 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA--EEIGEKL 2385
Query: 272 DFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENL 331
E+ T L + L R E+LR+ + +++ QE++ L + E +
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEM 2444
Query: 332 MAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRN 391
++ L +E + L K++ + + + E ++++ + A+A+QLR + +
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 392 LEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEE 448
+ Q+ RQ+ +++ R + E EE R+ + +Q +Q+ ++ E+L LAEE
Sbjct: 2505 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL---LAEE 2558
Score = 60.8 bits (146), Expect = 3e-09
Identities = 80/352 (22%), Positives = 153/352 (43%), Gaps = 53/352 (15%)
Query: 139 EGETVTRAEKSNPEESLR--AEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQL 196
E + +K N + L+ AE+ V E + R Q A+L + ++
Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---------RLSVAAQEAARLRQLAEED 2268
Query: 197 IHELVLLREPALQEVQQVHQDILAAYKLHAQAEL---ERDGLREEIRLVK----QKLFKV 249
+ + L E L+E Q Q+ A +L A+AEL +++ +E+ R ++ Q ++
Sbjct: 2269 LAQQRALAEKMLKEKMQAVQE---ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 250 TKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRD---AYQKQKEQL---- 302
+E +Q LE +Q + + E L R ++S A+ + ++KQ E++
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 303 -RQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEP--QFLRLLERKEAGTK 359
R +L L+ R+ S + E+ +LE E E Q +LL+ K +
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2445
Query: 360 ALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLE-----------DQIALVRQKRDEEVQ 408
+Q+ Q +QE + + +E L + R +E D++A +Q R+E+ +
Sbjct: 2446 TVQQEQL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 409 QYREQ----------LEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELS 450
Q ++ +EE RQ + GV+ +Q++ +++EQ R E L+
Sbjct: 2505 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLA 2556
Score = 60.5 bits (145), Expect = 3e-09
Identities = 97/384 (25%), Positives = 172/384 (44%), Gaps = 59/384 (15%)
Query: 110 EETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNP---EESLRAEQSP--SVE 164
+ E +R+ VE +E + + H + + A++ EE +R E++ + +
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1381
Query: 165 ENLSI-EDLELLEGRFQQCVQAVAQLEE--ERDQLIHE----LVLLREPALQEVQQVHQD 217
+ SI E+L+ L + +QA A+ E ER +L E +V L+ A + + +
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441
Query: 218 ILAAYKLHAQ-AELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREV 276
L A + A+ AE ++ +EE +++++ ++ + +L R + A+ A ++
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ- 1500
Query: 277 LTTRATQLSEELA--------QLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQF 328
RA Q EEL +LR A ++ Q++ LE +QR +S+R S
Sbjct: 1501 ---RALQALEELRLQAEEAERRLRQAEVERARQVQVALET--AQRSAEAELQSKRAS--- 1552
Query: 329 ENLMAESRQDLEEEYEPQFLRLLE-RKEAGTKALQRTQAEIQEMKEALRPLQA------E 381
AE LE + + + + + R+EA +A Q+ +AE + +EA R L+ E
Sbjct: 1553 ---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELERWQLKANE 1608
Query: 382 ARQLRLQNRNLEDQIALV-----------------RQKRDEEVQQYREQLEEMEERQRQL 424
A +LRLQ + Q +L R K +E+ + RE E+ E+QRQL
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Query: 425 RNGVQLQQQKNKEMEQLRLSLAEE 448
G QQ+ E E +RL E
Sbjct: 1669 AEGT-AQQRLAAEQELIRLRAETE 1691
Score = 55.5 bits (132), Expect = 1e-07
Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 25/303 (8%)
Query: 156 RAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVH 215
RAE+ S + LE GRF++ + A+L ++ + L E A + Q+
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR--QRAE 1798
Query: 216 QDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVA-QFADFR 274
+ + A KL A E R EI L KE A +L +D A Q
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIAL---------KEKEAENERLRRLAEDEAFQRRRLE 1849
Query: 275 EVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAE 334
E + E LAQLR A + E+ + +E QR +E L A FE A
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAG 1908
Query: 335 SRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNR---- 390
+ E E + R+ R A + QAE++ ++ + E R+ + R
Sbjct: 1909 -----KAELELELGRI--RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1961
Query: 391 -NLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEEL 449
E++ A R+ EEV++ + ++EE + + Q Q +E Q RL E+
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2021
Query: 450 STY 452
+
Sbjct: 2022 HAF 2024
Score = 54.3 bits (129), Expect = 2e-07
Identities = 63/313 (20%), Positives = 137/313 (43%), Gaps = 15/313 (4%)
Query: 146 AEKSNPEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
A+ E LR EQ+ E E +E + +Q + A+ E + +L +
Sbjct: 1207 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1266
Query: 206 PALQ-EVQQVHQDILAAYKLHAQAELERDGLREE-IRLVKQKLFKVTKECVAYQYQLECR 263
PA + +VQ + ++ Y E L + I+ + + L ++ +E + Q
Sbjct: 1267 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1326
Query: 264 QQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFL---QE 320
++ +A+ E + QL+E AQ + +++ ++L+Q+++ +R+ + Q+
Sbjct: 1327 RERLAEV----EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Query: 321 SRRLSAQFENLMAESRQDLE------EEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEA 374
R + + + L S +++ E E LR+ E L+ T+ + +
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 375 LRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQK 434
L+ L+A A + Q R +++ +R++ +E Q+ R+ E+ R + + +Q+
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502
Query: 435 NKEMEQLRLSLAE 447
+ +E+LRL E
Sbjct: 1503 LQALEELRLQAEE 1515
Score = 53.5 bits (127), Expect = 4e-07
Identities = 112/509 (22%), Positives = 191/509 (37%), Gaps = 65/509 (12%)
Query: 2 ASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAE---ALNPEVTL-----SSEGSL 53
A E R A QA + R++A + L +AE A +V L S+E L
Sbjct: 1491 AEAEAAREKQRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 54 NLEDILYLEDTGDLDETL---YVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVE 110
+ + E T L+ +L +V + EEA A Q EA E E
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAE--RRAQQQAEAERAREEAERELERWQL 1604
Query: 111 ETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIE 170
+ E R++ V K + + E R + + +A + + E +
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1664
Query: 171 DLELLEGRFQQCVQAVAQL----------EEERDQLIHELVLLREPALQEVQQ------- 213
+L EG QQ + A +L E++R L EL L+ A Q+
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1724
Query: 214 -----VHQDILAAYKLHAQAELERDGLREEIRLVKQ--KLFKVTKECVAYQY-------Q 259
++L A K A+ E + + RL + + ++ +E + Q
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784
Query: 260 LECRQQDVA-QFADFREVLTTR------ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQ 312
+ ++D A Q A+ VL + AT+L E + + E+LR+ E Q
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 313 RDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMK 372
R +++ + A E +A+ R+ + E E Q + E + ++ + EI +K
Sbjct: 1845 RR-RLEEQAAQHKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALK 1899
Query: 373 EALRPLQAEARQLRLQ----NRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGV 428
+ A +L L+ N ED + Q E +Q R+ E E R+R+ V
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERV 1958
Query: 429 QLQQQKNKEMEQLRLSLAEELSTYKGCLE 457
Q +E + R + EE+ K +E
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVE 1987
Score = 45.8 bits (107), Expect = 8e-05
Identities = 110/485 (22%), Positives = 189/485 (38%), Gaps = 75/485 (15%)
Query: 10 GDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDE 69
G G A+ + + P P + +E E+TL + +YLE +
Sbjct: 1005 GKGVARLSAEAEKVLALPEPSPAAPTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTI-- 1059
Query: 70 TLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGK 129
+L ++ T+ AEE L E Q EA V P E + + + R Q E +
Sbjct: 1060 SLVIRGTQGAEEVLRAHEE-QLKEAQAV--PATLPELEATKASLKKLRAQ-----AEAQQ 1111
Query: 130 PTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSVEENLSIED-----LELLEGRFQQCVQ 184
PT R E +E Q E ++ +E +LLE R+Q +
Sbjct: 1112 PTFD---------ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE-RWQAVLA 1161
Query: 185 AVAQLEEERDQLIHELVLLREPA------LQEVQQVHQDILAAYKLHAQA---------- 228
+ E +QL +L RE A LQ+ ++ + I A +QA
Sbjct: 1162 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1221
Query: 229 ---ELERDGLREEI--RLVKQKLFKVTK---ECVAYQYQLECRQQDVAQFADFREVLTTR 280
E+ER G + E R KQ + + + V Y+ QLE VA A +V +
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE----PVASPAKKPKV-QSG 1276
Query: 281 ATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLE 340
+ + +E LR Y + Q ++ F+ E+ R + E L + R +
Sbjct: 1277 SESVIQEYVDLRTHYSELTTLTSQYIK---------FISETLRRMEEEERLAEQQRAEER 1327
Query: 341 EEY-EPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAE-------ARQLRLQNRNL 392
E E + +R+ A A + QAE +E KE + +Q E A + Q R++
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 393 EDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTY 452
++++ +RQ + E+Q Q E E + ++ +++ + + + E+ R EL
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 453 KGCLE 457
+ E
Sbjct: 1447 RARAE 1451
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,950,825
Number of Sequences: 37866
Number of extensions: 878502
Number of successful extensions: 13486
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 456
Number of HSP's successfully gapped in prelim test: 985
Number of HSP's that attempted gapping in prelim test: 5503
Number of HSP's gapped (non-prelim): 4764
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.