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Search of human proteins with 119709825
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119709825 neuroblastoma breakpoint family, member 11-like
[Homo sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119709825 neuroblastoma breakpoint family, member 11-like [Ho... 1581 0.0
gi|156071420 hypothetical protein LOC728912 [Homo sapiens] 1580 0.0
gi|92110019 hypothetical protein LOC55672 [Homo sapiens] 1342 0.0
gi|239741309 PREDICTED: hypothetical protein XP_002344485 [Homo ... 1334 0.0
gi|224589132 hypothetical protein LOC100132406 [Homo sapiens] 1330 0.0
gi|83415174 hypothetical protein LOC400818 [Homo sapiens] 1318 0.0
gi|169162915 PREDICTED: hypothetical protein LOC728841 [Homo sap... 1023 0.0
gi|157266285 hypothetical protein LOC728936 [Homo sapiens] 998 0.0
gi|29789405 hypothetical protein LOC284565 [Homo sapiens] 995 0.0
gi|7657017 hypothetical protein LOC25832 [Homo sapiens] 880 0.0
gi|14149997 neuroblastoma breakpoint family, member 3 [Homo sapi... 806 0.0
gi|239741297 PREDICTED: neuroblastoma breakpoint family, member ... 538 e-153
gi|221136844 neuroblastoma breakpoint family, member 6 isoform 1... 481 e-136
gi|221218991 neuroblastoma breakpoint family, member 4 [Homo sap... 477 e-134
gi|221136848 neuroblastoma breakpoint family, member 6 isoform 2... 476 e-134
gi|114158664 hypothetical protein LOC343505 [Homo sapiens] 467 e-131
gi|239758011 PREDICTED: hypothetical protein LOC728841, partial ... 159 1e-38
gi|239747446 PREDICTED: similar to Neuroblastoma breakpoint fami... 113 8e-25
gi|239741304 PREDICTED: similar to Neuroblastoma breakpoint fami... 110 5e-24
gi|239741281 PREDICTED: Neuroblastoma breakpoint family member 6... 110 5e-24
gi|239752894 PREDICTED: Neuroblastoma breakpoint family member 6... 107 3e-23
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 79 1e-14
gi|21735548 centrosomal protein 2 [Homo sapiens] 64 7e-10
gi|71061468 centromere protein E [Homo sapiens] 59 2e-08
gi|148746195 trichohyalin [Homo sapiens] 59 2e-08
gi|154813191 IQ motif containing E isoform 1 [Homo sapiens] 58 4e-08
gi|154813193 IQ motif containing E isoform 2 [Homo sapiens] 58 4e-08
gi|7657138 golgi integral membrane protein 4 [Homo sapiens] 57 5e-08
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 56 1e-07
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 54 6e-07
>gi|119709825 neuroblastoma breakpoint family, member 11-like [Homo
sapiens]
Length = 790
Score = 1581 bits (4094), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MFSNSTGRLPGQPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDE 60
MFSNSTGRLPGQPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDE
Sbjct: 1 MFSNSTGRLPGQPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDE 60
Query: 61 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAE 120
PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAE
Sbjct: 61 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAE 120
Query: 121 ESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDAL 180
ESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDAL
Sbjct: 121 ESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDAL 180
Query: 181 NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFV 240
NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFV
Sbjct: 181 NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFV 240
Query: 241 TQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER 300
TQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER
Sbjct: 241 TQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER 300
Query: 301 ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP
Sbjct: 301 ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
Query: 361 ENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH 420
ENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH
Sbjct: 361 ENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH 420
Query: 421 RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEE 480
RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEE
Sbjct: 421 RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEE 480
Query: 481 VPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT 540
VPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT
Sbjct: 481 VPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT 540
Query: 541 GPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMD 600
GPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMD
Sbjct: 541 GPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMD 600
Query: 601 EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAV 660
EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAV
Sbjct: 601 EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAV 660
Query: 661 YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVV 720
YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVV
Sbjct: 661 YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVV 720
Query: 721 LNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIK 780
LNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIK
Sbjct: 721 LNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIK 780
Query: 781 THHAPGSAAC 790
THHAPGSAAC
Sbjct: 781 THHAPGSAAC 790
>gi|156071420 hypothetical protein LOC728912 [Homo sapiens]
Length = 790
Score = 1580 bits (4091), Expect = 0.0
Identities = 789/790 (99%), Positives = 790/790 (100%)
Query: 1 MFSNSTGRLPGQPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDE 60
MFSNSTGRLPGQPT+EIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDE
Sbjct: 1 MFSNSTGRLPGQPTQEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDE 60
Query: 61 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAE 120
PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAE
Sbjct: 61 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAE 120
Query: 121 ESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDAL 180
ESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDAL
Sbjct: 121 ESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDAL 180
Query: 181 NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFV 240
NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFV
Sbjct: 181 NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFV 240
Query: 241 TQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER 300
TQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER
Sbjct: 241 TQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQER 300
Query: 301 ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP
Sbjct: 301 ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
Query: 361 ENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH 420
ENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH
Sbjct: 361 ENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH 420
Query: 421 RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEE 480
RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEE
Sbjct: 421 RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEE 480
Query: 481 VPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT 540
VPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT
Sbjct: 481 VPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT 540
Query: 541 GPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMD 600
GPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMD
Sbjct: 541 GPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMD 600
Query: 601 EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAV 660
EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAV
Sbjct: 601 EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAV 660
Query: 661 YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVV 720
YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVV
Sbjct: 661 YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVV 720
Query: 721 LNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIK 780
LNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIK
Sbjct: 721 LNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGKKIK 780
Query: 781 THHAPGSAAC 790
THHAPGSAAC
Sbjct: 781 THHAPGSAAC 790
>gi|92110019 hypothetical protein LOC55672 [Homo sapiens]
Length = 1214
Score = 1342 bits (3472), Expect = 0.0
Identities = 685/768 (89%), Positives = 703/768 (91%), Gaps = 17/768 (2%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 361 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 421 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 480
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194
TCSNSHGPCDS QPHKNI ITFEEDKVNS+LVVDRESSHD CQDA+NILPVPGPTSSATN
Sbjct: 481 TCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDECQDAVNILPVPGPTSSATN 540
Query: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254
VSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFR+LKEKCFVTQ+ACFLA QQNKY
Sbjct: 541 VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLACFLANQQNKY 600
Query: 255 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314
KYEECKDLIKS+LRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD
Sbjct: 601 KYEECKDLIKSVLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 660
Query: 315 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374
ASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ L QKLSPENDND DEDVQVEV
Sbjct: 661 ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLFQKLSPENDNDHDEDVQVEV 720
Query: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434
AEKVQKSS+PREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS
Sbjct: 721 AEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 780
Query: 435 TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 494
TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS
Sbjct: 781 TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 840
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554
IPPE LASYQSYS TFHSLEEQQVCMAVDIG HRWDQVKKEDQEATGPRLSRELLDEK P
Sbjct: 841 IPPEMLASYQSYSGTFHSLEEQQVCMAVDIGGHRWDQVKKEDQEATGPRLSRELLDEKGP 900
Query: 555 EVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 614
EVLQDSLDRCYSTPS YL LTDSCQPYRSAFY+LEQQR+G A+DMDEIEKYQEVEEDQDP
Sbjct: 901 EVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQQRVGWALDMDEIEKYQEVEEDQDP 960
Query: 615 SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 674
SCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV
Sbjct: 961 SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 1020
Query: 675 DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVP 733
DRIKKDQEEEEDQGPPCPRLSRELLE VEPEVLQDSLD P L P
Sbjct: 1021 DRIKKDQEEEEDQGPPCPRLSRELLEAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSS 1080
Query: 734 FMHWRKNMLAFLLTWEKL----------------KRRGRGRKEGEEDQ 765
F + + F L ++ KRR RGRKEGEEDQ
Sbjct: 1081 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSTKKRRRRGRKEGEEDQ 1128
Score = 810 bits (2092), Expect = 0.0
Identities = 470/750 (62%), Positives = 538/750 (71%), Gaps = 58/750 (7%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQERELTQLREKLREGRDASRSLN+HLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 90 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 150 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 209
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194
TCSNSHGPCDS QPHKNI ITFEEDKVNS+LVVDRESSHD CQDA+NILPVPGPTSSATN
Sbjct: 210 TCSNSHGPCDSNQPHKNINITFEEDKVNSTLVVDRESSHDECQDAVNILPVPGPTSSATN 269
Query: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254
VSMVVSAGPLSSEKAEMNILE+NEKL PQLAEKKQQFR+LKEKCFVTQ+A FLA QQNKY
Sbjct: 270 VSMVVSAGPLSSEKAEMNILEMNEKLRPQLAEKKQQFRNLKEKCFVTQLAGFLANQQNKY 329
Query: 255 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314
KYEEC+DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD
Sbjct: 330 KYEECEDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 389
Query: 315 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374
ASRSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE
Sbjct: 390 ASRSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEE 449
Query: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434
AEKV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+ ITFEEDKV+S
Sbjct: 450 AEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNS 509
Query: 435 TLI--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ 483
L+ SSH E +DAV+I+P + ++ GP+S N+ E E+ PQ
Sbjct: 510 ALVVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQ 569
Query: 484 -ESWDEGYSTLSIP--PERLASYQSYSSTFHSLEE-QQVCMAVDIGRHRWDQVKKEDQ-- 537
+ + L +LA + + + EE + + +V ++ + K +Q
Sbjct: 570 LAEKKQQFRNLKEKCFVTQLACFLANQQNKYKYEECKDLIKSVLRNERQFKEEKLAEQLK 629
Query: 538 EATGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQ 591
+A R + L+ +E E+ L++ D S L +P +S L++Q
Sbjct: 630 QAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQ 689
Query: 592 -----RIGLAV----------DMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSL 636
R+ + D DE + + E+ Q S P RE+ +E EV +DSL
Sbjct: 690 LAEGCRLAQQLFQKLSPENDNDHDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSL 746
Query: 637 DRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLAL--------------DVDRIKKDQE 682
+ C T S D QP+R + EE + L + + D E
Sbjct: 747 EECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDE 806
Query: 683 EEEDQGPPCPRLSRELLEVVEPEVLQDSLD 712
EEE++GP P R L E E EV Q+S D
Sbjct: 807 EEEEKGPVSP---RNLQESEEEEVPQESWD 833
Score = 449 bits (1155), Expect = e-126
Identities = 279/524 (53%), Positives = 340/524 (64%), Gaps = 41/524 (7%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
MVVSAGP SSEKAE NILEINEKL PQLAE KQQFR+LKEKCFVTQ+A FLA +Q KYKY
Sbjct: 1 MVVSAGPWSSEKAETNILEINEKLRPQLAENKQQFRNLKEKCFVTQLAGFLANRQKKYKY 60
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316
EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
Query: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376
RSLN+HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNQHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
Query: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436
KV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+ ITFEEDKV+STL
Sbjct: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNINITFEEDKVNSTL 240
Query: 437 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQ-E 484
+ SSH E +DAV+I+P + ++ GP+S N+ E E+ PQ
Sbjct: 241 VVDRESSHDECQDAVNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEMNEKLRPQLA 300
Query: 485 SWDEGYSTLSIP--PERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW---DQVKKEDQEA 539
+ + L +LA + + + EE + + + R +++ ++ ++A
Sbjct: 301 EKKQQFRNLKEKCFVTQLAGFLANQQNKYKYEECEDLIKSMLRNERQFKEEKLAEQLKQA 360
Query: 540 TGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQ--- 590
R + L+ +E E+ L++ D S L +P +S L++
Sbjct: 361 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNQHLQALLTPDEPDKSQGQDLQEQLA 420
Query: 591 ----------QRIGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLAEKEPEVLQDSLDR 638
Q++ D DE E Q E E+ + S P RE+ +E +V +DSL+
Sbjct: 421 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAP---REVQKAEESKVPEDSLEE 477
Query: 639 CYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQE 682
C T S D QP+++ + EE + AL VDR E
Sbjct: 478 CAITCSNSHGPCDSNQPHKNINITFEEDKVNSALVVDRESSHDE 521
Score = 231 bits (589), Expect = 2e-60
Identities = 143/326 (43%), Positives = 188/326 (57%), Gaps = 34/326 (10%)
Query: 373 EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429
+V ++ Q+++ PR E+ + EV +DSL+ C T S DS QP+R E+
Sbjct: 877 QVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYILEQ 936
Query: 430 DKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEG 489
+V W + I + + +E+++ P R L + +E EV Q+S D
Sbjct: 937 QRVG-----------WALDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 985
Query: 490 YSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELL 549
YST S E Q Y S +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL
Sbjct: 986 YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 1045
Query: 550 DEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---- 605
+ EPEVLQDSLDRCYSTPS L DSC PY S+FY LE++ +G ++D+ EIEK
Sbjct: 1046 EAVEPEVLQDSLDRCYSTPSSCLEQPDSCLPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1105
Query: 606 ----------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649
+E EEDQ+P CPRLS L+ +EPEVLQDSLDRCYSTPS Y EL
Sbjct: 1106 KRRGRRSTKKRRRRGRKEGEEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFEL 1165
Query: 650 PDLGQPYRSAVYSLEEQYLGLALDVD 675
PD Q YRS YS EEQ++ ALDVD
Sbjct: 1166 PDSFQHYRSVFYSFEEQHISFALDVD 1191
Score = 34.3 bits (77), Expect = 0.46
Identities = 21/67 (31%), Positives = 35/67 (52%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ + + EE +V +DSL+ C T S DS Q ++++ +FEE +
Sbjct: 1125 EEDQNPPCPRLSGMLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHI 1184
Query: 162 NSSLVVD 168
+ +L VD
Sbjct: 1185 SFALDVD 1191
>gi|239741309 PREDICTED: hypothetical protein XP_002344485 [Homo
sapiens]
Length = 4621
Score = 1334 bits (3453), Expect = 0.0
Identities = 683/765 (89%), Positives = 706/765 (92%), Gaps = 6/765 (0%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLT DEPDKSQGQDLQEQLA
Sbjct: 90 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTLDEPDKSQGQDLQEQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKV +SSAPREVQK EESKVPEDSLEECAI
Sbjct: 150 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVQKSSAPREVQKTEESKVPEDSLEECAI 209
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194
TCSNSHGPCDS QPHKNIKITFEED+VNS+LVVDRESSHD CQDALNILPVPGPTSSATN
Sbjct: 210 TCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNILPVPGPTSSATN 269
Query: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254
VSMVVSAGPLSSEKAEMNILEINEKL PQLAEKKQQFR+LKE+CFVTQ+A FLA QQ KY
Sbjct: 270 VSMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKERCFVTQLAGFLANQQKKY 329
Query: 255 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314
KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRD
Sbjct: 330 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRD 389
Query: 315 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374
ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVE+
Sbjct: 390 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEL 449
Query: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434
AEKVQKSS+PREMQKAEEKEVPEDS EECAIT SNSHGPYDSNQPHRKTKITFEEDKVDS
Sbjct: 450 AEKVQKSSAPREMQKAEEKEVPEDSQEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDS 509
Query: 435 TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 494
TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS
Sbjct: 510 TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 569
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554
IPPE LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK P
Sbjct: 570 IPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGP 629
Query: 555 EVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 614
EVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP
Sbjct: 630 EVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 689
Query: 615 SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 674
SCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDV
Sbjct: 690 SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDV 749
Query: 675 DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVP 733
DR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L P
Sbjct: 750 DRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSS 809
Query: 734 FMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 810 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 854
Score = 452 bits (1162), Expect = e-127
Identities = 301/595 (50%), Positives = 360/595 (60%), Gaps = 72/595 (12%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
MVVSAGP SSEKAEMNILEINEKL PQLAE KQQF +LKE+CFVTQ+A FLA QQ KY Y
Sbjct: 1 MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFVTQLAGFLANQQKKYNY 60
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316
EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
Query: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376
RSLNEHLQALLT DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
Query: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436
KVQKSS+PRE+QK EE +VPEDSLEECAITCSNSHGP DSNQPH+ KITFEED+V+STL
Sbjct: 181 KVQKSSAPREVQKTEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240
Query: 437 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQES 485
+ SSH E +DA++I+P + ++ GP+S N+ E E+ PQ +
Sbjct: 241 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLA 300
Query: 486 WDEGYSTLSIPPER-----LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT 540
E ER LA + + + EE C + R ++ KE++ A
Sbjct: 301 --EKKQQFRNLKERCFVTQLAGFLANQQKKYKYEE---CKDLIKSMLRNERQFKEEKLAE 355
Query: 541 GPRLSREL--------LDEKE----PEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVL 588
+ + EL E+E E L++ D S L +P +S L
Sbjct: 356 QLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDL 415
Query: 589 EQQ-----RIGLAV----------DMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQ 633
++Q R+ + D DE + + E+ Q S P RE+ +E EV +
Sbjct: 416 QEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVELAEKVQKSSAP---REMQKAEEKEVPE 472
Query: 634 DSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLAL--------------DVDRIKK 679
DS + C T S D QP+R + EE + L + +
Sbjct: 473 DSQEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 532
Query: 680 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD----VIQLLPVVLNSLTPASPT 730
D EEEE++GP P R L E E EV Q+S D + + P +L S S T
Sbjct: 533 DDEEEEEKGPVSP---RNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSST 584
Score = 413 bits (1062), Expect = e-115
Identities = 300/733 (40%), Positives = 383/733 (52%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 666 QRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 725
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 726 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 764
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 765 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 807
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 808 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 863
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+S +L + C R A +++++ D DE +
Sbjct: 864 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 923
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 924 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 983
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 984 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 1029
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 1030 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 1089
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFY
Sbjct: 1090 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY 1149
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 1150 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 1209
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 1210 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 1269
Query: 707 LQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 1270 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 1329
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 1330 KKERRRGRKEGEE 1342
Score = 413 bits (1061), Expect = e-115
Identities = 300/733 (40%), Positives = 383/733 (52%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 1154 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 1213
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 1214 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 1252
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 1253 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 1295
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 1296 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1351
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+S +L + C R A +++++ D DE +
Sbjct: 1352 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 1411
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 1412 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 1471
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 1472 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 1517
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 1518 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 1577
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFY
Sbjct: 1578 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY 1637
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 1638 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 1697
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 1698 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 1757
Query: 707 LQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 1758 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 1817
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 1818 KKERRRGRKEGEE 1830
Score = 411 bits (1056), Expect = e-114
Identities = 297/733 (40%), Positives = 380/733 (51%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 3369 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 3428
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 3429 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 3467
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 3468 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 3510
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHL 323
S E E+ + L E ++ K R + R +EG + L
Sbjct: 3511 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 3566
Query: 324 QALLTPDEPDKSQGQDLQE---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
L ++ + L +L + C R A +++++ D DE +
Sbjct: 3567 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 3626
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 3627 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 3686
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 3687 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 3732
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 3733 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 3792
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFY
Sbjct: 3793 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY 3852
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 3853 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 3912
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 3913 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 3972
Query: 707 LQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 3973 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 4032
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 4033 KKERRRGRKEGEE 4045
Score = 410 bits (1055), Expect = e-114
Identities = 297/733 (40%), Positives = 380/733 (51%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 3613 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 3672
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 3673 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 3711
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 3712 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 3754
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHL 323
S E E+ + L E ++ K R + R +EG + L
Sbjct: 3755 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 3810
Query: 324 QALLTPDEPDKSQGQDLQE---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
L ++ + L +L + C R A +++++ D DE +
Sbjct: 3811 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 3870
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 3871 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 3930
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 3931 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 3976
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 3977 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 4036
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFY
Sbjct: 4037 RRGRKEGEEDQTPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY 4096
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 4097 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 4156
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 4157 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 4216
Query: 707 LQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 4217 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 4276
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 4277 KKERRRGRKEGEE 4289
Score = 410 bits (1053), Expect = e-114
Identities = 296/740 (40%), Positives = 382/740 (51%), Gaps = 95/740 (12%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 3857 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 3916
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 3917 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 3955
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 3956 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 3998
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 3999 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQTPPCPRL 4054
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+ +L + C R A +++++ D DE +
Sbjct: 4055 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 4114
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 4115 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 4174
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 4175 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 4220
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 4221 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 4280
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFY
Sbjct: 4281 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY 4340
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 4341 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 4400
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 4401 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 4460
Query: 707 LQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQ 765
LQDSLD P L P F + + F L +++++G+G+K
Sbjct: 4461 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 4520
Query: 766 RRKEEGEEKKGKKIKTHHAP 785
++K K+G++ + P
Sbjct: 4521 KKKRRRGRKEGEEDQNPPCP 4540
Score = 409 bits (1051), Expect = e-114
Identities = 299/733 (40%), Positives = 382/733 (52%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 1642 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 1701
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 1702 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 1740
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 1741 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 1783
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 1784 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1839
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+S +L + C R A +++++ D DE +
Sbjct: 1840 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 1899
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 1900 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 1959
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 1960 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 2005
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 2006 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 2065
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDR YSTPS L LTDSCQPYRSAFY
Sbjct: 2066 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFY 2125
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 2126 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 2185
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 2186 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 2245
Query: 707 LQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 2246 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 2305
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 2306 KKERRRGRKEGEE 2318
Score = 409 bits (1051), Expect = e-114
Identities = 299/733 (40%), Positives = 382/733 (52%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 1886 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 1945
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 1946 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 1984
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 1985 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 2027
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 2028 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 2083
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+S +L + C R A +++++ D DE +
Sbjct: 2084 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 2143
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 2144 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 2203
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 2204 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 2249
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 2250 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 2309
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDR YSTPS L LTDSCQPYRSAFY
Sbjct: 2310 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFY 2369
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 2370 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 2429
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 2430 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 2489
Query: 707 LQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 2490 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 2549
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 2550 KKERRRGRKEGEE 2562
Score = 409 bits (1051), Expect = e-114
Identities = 299/733 (40%), Positives = 382/733 (52%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 2130 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 2189
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 2190 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 2228
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 2229 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 2271
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 2272 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 2327
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+S +L + C R A +++++ D DE +
Sbjct: 2328 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 2387
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 2388 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 2447
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 2448 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 2493
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 2494 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 2553
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDR YSTPS L LTDSCQPYRSAFY
Sbjct: 2554 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFY 2613
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 2614 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 2673
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 2674 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 2733
Query: 707 LQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 2734 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 2793
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 2794 KKERRRGRKEGEE 2806
Score = 407 bits (1046), Expect = e-113
Identities = 296/733 (40%), Positives = 379/733 (51%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 1398 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 1457
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 1458 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 1496
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 1497 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 1539
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHL 323
S E E+ + L E ++ K R + R +EG + L
Sbjct: 1540 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1595
Query: 324 QALLTPDEPDKSQGQDLQE---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
L ++ + L +L + C R A +++++ D DE +
Sbjct: 1596 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 1655
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 1656 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 1715
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 1716 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 1761
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 1762 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 1821
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDR YSTPS L LTDSCQPYRSAFY
Sbjct: 1822 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFY 1881
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 1882 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 1941
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 1942 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 2001
Query: 707 LQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 2002 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 2061
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 2062 KKERRRGRKEGEE 2074
Score = 406 bits (1043), Expect = e-113
Identities = 290/715 (40%), Positives = 371/715 (51%), Gaps = 99/715 (13%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ +E +V +DSL+ C T S D QP+ + + EE +
Sbjct: 3143 EEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL 3202
Query: 162 NSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLC 221
+L VDR ++ GP + +LE+ E
Sbjct: 3203 GLALDVDRTKKDQEEEE---------------------DQGP-PCPRLSRELLEVVE--- 3237
Query: 222 PQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQ 281
P++ + ++C+ T +C + + C+ S E E+ +
Sbjct: 3238 PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYGSSFYALE----EKHVGFS 3280
Query: 282 LKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQ 341
L E ++ K R + R +EG + L L ++ + L
Sbjct: 3281 LDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLD 3340
Query: 342 E---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---E 386
+L + C R A +++++ D DE + + E+ Q S PR E
Sbjct: 3341 RCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRE 3400
Query: 387 MQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWE 446
+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 3401 LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------- 3451
Query: 447 DAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLASY 503
+ + D EEEE++GP PR L E E EV Q+S D YST S E+ S
Sbjct: 3452 -----VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 3506
Query: 504 QSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKEDQEATGPRL 544
Q Y S+F++LEE+ V ++D+G R R + +EDQ PRL
Sbjct: 3507 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 3566
Query: 545 SRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEK 604
SRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+GLAVDMDEIEK
Sbjct: 3567 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 3626
Query: 605 YQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLE 664
YQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLE
Sbjct: 3627 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 3686
Query: 665 EQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPV-VLNS 723
EQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L
Sbjct: 3687 EQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 3746
Query: 724 LTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 3747 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 3801
Score = 362 bits (928), Expect = e-99
Identities = 281/736 (38%), Positives = 370/736 (50%), Gaps = 87/736 (11%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 2618 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 2677
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 2678 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 2716
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQNKYKYE 257
+ +LE+ E L + + S C +C F A ++ +
Sbjct: 2717 -PCPRLSRELLEVVEP--EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFS 2773
Query: 258 ----ECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGR 313
E + K R R+ K+E+ + K+ EE + S+E + E L++
Sbjct: 2774 LDVGEIEKKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKEPEVLQDSL 2832
Query: 314 DASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVE 373
D S L +P S L+EQ +L L + D E+
Sbjct: 2833 DRCYSTPSGYLELPDLGQPYSSAVYSLEEQ---------YLGLALDVDRTKKDQEE---- 2879
Query: 374 VAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEED 430
E+ Q PR E+ + E EV +DSL+ C T S+ DS QP+ + EE
Sbjct: 2880 --EEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEK 2937
Query: 431 KVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPR---NLQESEEEEVP 482
V +L + + ++ + E EE++ P PR L + +E EV
Sbjct: 2938 HVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVL 2997
Query: 483 QESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGP 542
Q+S D YST S E Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ P
Sbjct: 2998 QDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCP 3057
Query: 543 RLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEI 602
RLSRELL+ EPEVLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EI
Sbjct: 3058 RLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEI 3117
Query: 603 EKY-------------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTP 643
EK +E EEDQ+P CPRLSRELL EKEPEVLQDSLDRCYSTP
Sbjct: 3118 EKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTP 3177
Query: 644 SGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVE 703
SGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVE
Sbjct: 3178 SGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVE 3237
Query: 704 PEVLQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RG 757
PEVLQDSLD P L P F + + F L +++++G RG
Sbjct: 3238 PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 3297
Query: 758 RKEGEEDQRRKEEGEE 773
R+ +E +R ++EGEE
Sbjct: 3298 RRSKKERRRGRKEGEE 3313
Score = 358 bits (918), Expect = 1e-98
Identities = 283/779 (36%), Positives = 387/779 (49%), Gaps = 98/779 (12%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 2374 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 2433
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP + ++ P
Sbjct: 2434 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEED------QGPPCPRLSRELLEVVEP 2487
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQ----QFRSLKEKCFVTQVACFLAKQQNKYKYEEC 259
+ + ++ C + + Q F +L+EK + +++ K K
Sbjct: 2488 EVLQDS-LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 2546
Query: 260 KDLIKSMLRNERQFKEEKLAEQLKQAEELRQYK---VLVHSQERELT------QLREKLR 310
+ K R ++ +E++ + + EL K VL S +R + +L + +
Sbjct: 2547 RRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQ 2606
Query: 311 EGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGC-RLAQHLVQKLSPENDNDD--- 366
R A L E + L D + + Q+++E C RL++ L+ + PE D
Sbjct: 2607 PYRSAFYVL-EQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 2665
Query: 367 ----------------------------------DEDVQVEVAEKVQKSSSP-----REM 387
D D + E+ + P RE+
Sbjct: 2666 CYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSREL 2725
Query: 388 QKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWED 447
+ E EV +DSL+ C T S+ DS QP+ + EE V +L + +
Sbjct: 2726 LEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKG 2785
Query: 448 AVHIIPENESD-----DEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPER 499
++ + E EE++ P PR L + +E EV Q+S D YST S E
Sbjct: 2786 KKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLEL 2845
Query: 500 LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQD 559
Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL+ EPEVLQD
Sbjct: 2846 PDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQD 2905
Query: 560 SLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY-------------- 605
SLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 2906 SLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKE 2965
Query: 606 -----QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAV 660
+E EEDQ+P CPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAV
Sbjct: 2966 RRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAV 3025
Query: 661 YSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPV- 719
YSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P
Sbjct: 3026 YSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSS 3085
Query: 720 VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
L P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 3086 CLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 3144
Score = 296 bits (759), Expect = 4e-80
Identities = 259/796 (32%), Positives = 368/796 (46%), Gaps = 96/796 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 919 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 978
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 979 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 1031
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTS 190
C T S+ DS QP+ + EE V SL V E G G
Sbjct: 1032 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG-EIEKKG----------KGKKR 1080
Query: 191 SATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEK------KQQFRSLKEKCFVTQVA 244
G E E CP+L+ + + + ++C+ T
Sbjct: 1081 RGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSG 1133
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C + C+ R+ E++ +E+ +Y+ + Q+ +
Sbjct: 1134 CLELT-------DSCQP-----YRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPR 1181
Query: 305 LREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
L +L + ++ + + TP + PD Q E Q+L L
Sbjct: 1182 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE----EQYLGLALDV 1237
Query: 361 ENDNDDDEDVQVEVAEKVQKSSSP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSN 417
+ D E+ E+ Q P RE+ + E EV +DSL+ C T S+ DS
Sbjct: 1238 DRTKKDQEE------EEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 1291
Query: 418 QPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRN 472
QP+ + EE V +L + + ++ + E EE++ P PR
Sbjct: 1292 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1351
Query: 473 LQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW 529
+E +E EV Q+S D YST S E S Q Y S F+ LE+Q+V +AVD+
Sbjct: 1352 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 1411
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY SA Y LE
Sbjct: 1412 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 1471
Query: 590 QQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649
+Q +GLA+D+D +K QE EEDQ P CPRLSRELL EPEVLQDSLDRCYSTPS LE
Sbjct: 1472 EQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 1531
Query: 650 PDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQGPP 690
PD QPY S+ Y+LEE+++G +LDV I+K +E EEDQ PP
Sbjct: 1532 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPP 1591
Query: 691 CPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA-SPTEVPFMHWRKNMLAFLLTWE 749
CPRLSRELL+ PEVLQDSLD P LT + P F + + + +
Sbjct: 1592 CPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 1651
Query: 750 KLKRRGRGRKEGEEDQ 765
++++ +E EEDQ
Sbjct: 1652 EIEK----YQEVEEDQ 1663
Score = 295 bits (754), Expect = 1e-79
Identities = 259/796 (32%), Positives = 368/796 (46%), Gaps = 96/796 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 3378 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 3437
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 3438 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 3490
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTS 190
C T S+ DS QP+ + EE V SL V E G G
Sbjct: 3491 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG-EIEKKG----------KGKKR 3539
Query: 191 SATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEK------KQQFRSLKEKCFVTQVA 244
G E E CP+L+ + + + ++C+ T
Sbjct: 3540 RGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSG 3592
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C + C+ R+ E++ +E+ +Y+ + Q+ +
Sbjct: 3593 CLELT-------DSCQP-----YRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPR 3640
Query: 305 LREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
L +L + ++ + + TP + PD Q E Q+L L
Sbjct: 3641 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE----EQYLGLALDV 3696
Query: 361 ENDNDDDEDVQVEVAEKVQKSSSP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSN 417
+ D E+ E+ Q P RE+ + E EV +DSL+ C T S+ DS
Sbjct: 3697 DRTKKDQEE------EEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 3750
Query: 418 QPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRN 472
QP+ + EE V +L + + ++ + E EE++ P PR
Sbjct: 3751 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 3810
Query: 473 LQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW 529
+E +E EV Q+S D YST S E S Q Y S F+ LE+Q+V +AVD+
Sbjct: 3811 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 3870
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY SA Y LE
Sbjct: 3871 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 3930
Query: 590 QQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649
+Q +GLA+D+D +K QE EEDQ P CPRLSRELL EPEVLQDSLDRCYSTPS LE
Sbjct: 3931 EQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 3990
Query: 650 PDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQGPP 690
PD QPY S+ Y+LEE+++G +LDV I+K +E EEDQ PP
Sbjct: 3991 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQTPP 4050
Query: 691 CPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA-SPTEVPFMHWRKNMLAFLLTWE 749
CPRLSRELL+ PEVLQDSLD P LT + P F + + + +
Sbjct: 4051 CPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 4110
Query: 750 KLKRRGRGRKEGEEDQ 765
++++ +E EEDQ
Sbjct: 4111 EIEK----YQEVEEDQ 4122
Score = 295 bits (754), Expect = 1e-79
Identities = 256/776 (32%), Positives = 360/776 (46%), Gaps = 101/776 (13%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 3866 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 3925
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 3926 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 3978
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTS 190
C T S+ DS QP+ + EE V SL V E G G
Sbjct: 3979 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG-EIEKKG----------KGKKR 4027
Query: 191 SATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEK------KQQFRSLKEKCFVTQVA 244
G E E CP+L+ + + + ++C+ T
Sbjct: 4028 RGRRSKKERRRGRKEGE-------EDQTPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSG 4080
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C + C+ R+ E++ +E+ +Y+ + Q+ +
Sbjct: 4081 CLELT-------DSCQPY-----RSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPR 4128
Query: 305 LREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
L +L + ++ + + TP + PD Q E Q+L L
Sbjct: 4129 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE----EQYLGLALDV 4184
Query: 361 ENDNDDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSN 417
+ D E+ E+ Q PR E+ + E EV +DSL+ C T S+ DS
Sbjct: 4185 DRTKKDQEE------EEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 4238
Query: 418 QPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRN 472
QP+ + EE V +L + + ++ + E EE++ P PR
Sbjct: 4239 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 4298
Query: 473 LQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW 529
+E +E EV Q+S D YST S E S Q Y S F+ LE+Q+V +AVD+
Sbjct: 4299 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 4358
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY SA Y LE
Sbjct: 4359 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 4418
Query: 590 QQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649
+Q +GLA+D+D +K QE EEDQ P CPRLSRELL EPEVLQDSLDRCYSTPS LE
Sbjct: 4419 EQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 4478
Query: 650 PDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQGPP 690
PD QPY S+ Y+LEE+++G +LDV I+K +E EEDQ PP
Sbjct: 4479 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPP 4538
Query: 691 CPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPASPTEVP--FMHWRKNMLAF 744
CPRL+ L+EV EPEVLQDSLD TP+ E+P F H+R +F
Sbjct: 4539 CPRLNGVLMEVEEPEVLQDSLDGCY--------STPSMYFELPDSFQHYRSVFYSF 4586
Score = 290 bits (742), Expect = 4e-78
Identities = 255/796 (32%), Positives = 367/796 (46%), Gaps = 96/796 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 1651 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 1710
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 1711 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 1763
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVV-------------DRESSHDGCQ 177
C T S+ DS QP+ + EE V SL V R S + +
Sbjct: 1764 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRR 1823
Query: 178 DALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEK 237
P + ++ GP + + ++ C +L + Q +RS
Sbjct: 1824 GRKEGEEDQNPPCPRLSRELLDEKGPEVLQDS-LDRSYSTPSGCLELTDSCQPYRSAFYV 1882
Query: 238 CFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHS 297
+V + + + E +D S R R+ +EK E L+ + + +S
Sbjct: 1883 LEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLD------RCYS 1936
Query: 298 QERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQK 357
+L + + A SL E L + K ++ ++Q RL++ L++
Sbjct: 1937 TPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEV 1996
Query: 358 LSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSN 417
+ P EV +DSL+ C T S+ DS
Sbjct: 1997 VEP---------------------------------EVLQDSLDRCYSTPSSCLEQPDSC 2023
Query: 418 QPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRN 472
QP+ + EE V +L + + ++ + E EE++ P PR
Sbjct: 2024 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 2083
Query: 473 LQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW 529
+E +E EV Q+S D YST S E S Q Y S F+ LE+Q+V +AVD+
Sbjct: 2084 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 2143
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY SA Y LE
Sbjct: 2144 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 2203
Query: 590 QQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649
+Q +GLA+D+D +K QE EEDQ P CPRLSRELL EPEVLQDSLDRCYSTPS LE
Sbjct: 2204 EQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 2263
Query: 650 PDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQGPP 690
PD QPY S+ Y+LEE+++G +LDV I+K +E EEDQ PP
Sbjct: 2264 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPP 2323
Query: 691 CPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA-SPTEVPFMHWRKNMLAFLLTWE 749
CPRLSRELL+ PEVLQDSLD P LT + P F + + + +
Sbjct: 2324 CPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 2383
Query: 750 KLKRRGRGRKEGEEDQ 765
++++ +E EEDQ
Sbjct: 2384 EIEK----YQEVEEDQ 2395
Score = 226 bits (577), Expect = 5e-59
Identities = 142/313 (45%), Positives = 179/313 (57%), Gaps = 36/313 (11%)
Query: 385 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 444
RE+ + EV +DSL+ C T S DS QP+R E+ +V +
Sbjct: 4300 RELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVD------- 4352
Query: 445 WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLA 501
+ E E E EE++ P PR L + +E EV Q+S D YST S E
Sbjct: 4353 -------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD 4405
Query: 502 SYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSL 561
Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL+ EPEVLQDSL
Sbjct: 4406 LGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSL 4465
Query: 562 DRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---------------- 605
DRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 4466 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRR 4525
Query: 606 ---QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 662
+E EEDQ+P CPRL+ L+ +EPEVLQDSLD CYSTPS Y ELPD Q YRS YS
Sbjct: 4526 RGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYS 4585
Query: 663 LEEQYLGLALDVD 675
EEQ++ AL VD
Sbjct: 4586 FEEQHISFALYVD 4598
Score = 35.8 bits (81), Expect = 0.16
Identities = 39/157 (24%), Positives = 67/157 (42%), Gaps = 11/157 (7%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 2627 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2686
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 2687 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 2739
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVV 167
C T S+ DS QP+ + EE V SL V
Sbjct: 2740 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 2776
Score = 33.9 bits (76), Expect = 0.60
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 116 VQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVD 168
+ + EE +V +DSL+ C T S DS Q ++++ +FEE ++ +L VD
Sbjct: 4546 LMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVD 4598
>gi|224589132 hypothetical protein LOC100132406 [Homo sapiens]
Length = 3628
Score = 1330 bits (3441), Expect = 0.0
Identities = 679/765 (88%), Positives = 705/765 (92%), Gaps = 6/765 (0%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQERELTQLREKLREGRDASRSL EHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 90 EELRQYKVLVHSQERELTQLREKLREGRDASRSLYEHLQALLTPDEPDKSQGQDLQEQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPENDEDEDEDVQVEE EKVLESSAPREVQKAEESKVPEDSLEECAI
Sbjct: 150 EGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAI 209
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194
TCSNSHGPCDS QPHKNIKITFEED+VNS+LVVDRESSHD CQDALNILPVPGPTSSATN
Sbjct: 210 TCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNILPVPGPTSSATN 269
Query: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254
VSMVVSAGPLSSEKAEMNILEINEKL PQLAEKKQQFR+LKEKCF+TQ++ FLA QQ KY
Sbjct: 270 VSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLSGFLANQQKKY 329
Query: 255 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314
KYEECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQL+EKLREGRD
Sbjct: 330 KYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLKEKLREGRD 389
Query: 315 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374
ASRSLNEHLQALLTP EPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV
Sbjct: 390 ASRSLNEHLQALLTPYEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 449
Query: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434
AEKVQKSS+PREMQKAEEKEVPEDSLEECAIT SNSHG YDSNQPHRKTKITFEEDKVDS
Sbjct: 450 AEKVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGSYDSNQPHRKTKITFEEDKVDS 509
Query: 435 TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 494
TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS
Sbjct: 510 TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 569
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554
IPPE LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK P
Sbjct: 570 IPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGP 629
Query: 555 EVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 614
EV QDS DRCYSTPS L LTDSCQPYRSAFY+LEQQR+GLA+DMDEIEKYQEVEEDQDP
Sbjct: 630 EVFQDSQDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAIDMDEIEKYQEVEEDQDP 689
Query: 615 SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 674
SCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDV
Sbjct: 690 SCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDV 749
Query: 675 DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPV-VLNSLTPASPTEVP 733
DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L P
Sbjct: 750 DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSS 809
Query: 734 FMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 810 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 854
Score = 642 bits (1657), Expect = 0.0
Identities = 406/800 (50%), Positives = 483/800 (60%), Gaps = 103/800 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVH+QERELTQL+EKLREGRDASRSLNEHLQALLTP EPDKSQGQDLQEQLA
Sbjct: 361 EELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQLA 420
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPEND D+DEDVQVE EKV +SSAPRE+QKAEE +VPEDSLEECAI
Sbjct: 421 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 480
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV--------- 185
T SNSHG DS QPH+ KITFEEDKV+S+L+ SSH +DA++I+P
Sbjct: 481 TYSNSHGSYDSNQPHRKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 538
Query: 186 -PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVA 244
GP S P S + L I ++ F SL+E Q
Sbjct: 539 EKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEE-----QQV 593
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C +A ++++++ K KE++ A + + EL K
Sbjct: 594 C-MAVDIGRHRWDQVK-------------KEDQEATGPRLSRELLDEKG----------- 628
Query: 305 LREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN 364
E ++ +D S L +P +S L++Q G +
Sbjct: 629 -PEVFQDSQDRCYSTPSGCLELTDSCQPYRSAFYILEQQRV-GLAI-------------- 672
Query: 365 DDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 421
D DE + + E+ Q S PR E+ +E EV +DSL+ C T S D QP+
Sbjct: 673 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 732
Query: 422 KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEE 478
+ EE + L + + D EEEE++GP PR L E E
Sbjct: 733 SAVYSLEEQYLGLALD--------------VDRIKKDQEEEEDQGPPCPRLSRELLEVVE 778
Query: 479 EEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG------------- 525
EV Q+S D YST S E+ S Q Y S+F++LEE+ V ++D+G
Sbjct: 779 PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 838
Query: 526 ------RHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQ 579
R R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQ
Sbjct: 839 RRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQ 898
Query: 580 PYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRC 639
PYRSAFYVLEQQR+G AVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRC
Sbjct: 899 PYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 958
Query: 640 YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 699
YSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL
Sbjct: 959 YSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 1018
Query: 700 EVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG--- 755
EVVEPEVLQDSLD P L P F + + F L +++++G
Sbjct: 1019 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1078
Query: 756 --RGRKEGEEDQRRKEEGEE 773
RGR+ +E +R ++EGEE
Sbjct: 1079 KRRGRRSKKERRRGRKEGEE 1098
Score = 455 bits (1170), Expect = e-128
Identities = 294/591 (49%), Positives = 368/591 (62%), Gaps = 64/591 (10%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
MVVSAGP SSEKAEMNILEINE L PQLAEKKQQFR+LKEKCF+TQ+A FLA +Q KYKY
Sbjct: 1 MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316
EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
Query: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376
RSL EHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE AE
Sbjct: 121 RSLYEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAE 180
Query: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436
KV +SS+PRE+QKAEE +VPEDSLEECAITCSNSHGP DSNQPH+ KITFEED+V+STL
Sbjct: 181 KVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240
Query: 437 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQES 485
+ SSH E +DA++I+P + ++ GP+S N+ E E+ PQ +
Sbjct: 241 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA 300
Query: 486 WDEGYSTLSIPPE----RLASYQSYSSTFHSLEEQQVCMAVDIGRHRW---DQVKKEDQE 538
++ ++ + +L+ + + + EE + + + R +++ ++ ++
Sbjct: 301 -EKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQ 359
Query: 539 ATGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQ- 591
A R + L+ +E E+ L++ D S L +P +S L++Q
Sbjct: 360 AEELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQL 419
Query: 592 ----RIGLAV----------DMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLD 637
R+ + D DE + + E+ Q S P RE+ +E EV +DSL+
Sbjct: 420 AEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLE 476
Query: 638 RCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLAL--------------DVDRIKKDQEE 683
C T S D QP+R + EE + L + + D EE
Sbjct: 477 ECAITYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEE 536
Query: 684 EEDQGPPCPRLSRELLEVVEPEVLQDSLD----VIQLLPVVLNSLTPASPT 730
EE++GP P R L E E EV Q+S D + + P +L S S T
Sbjct: 537 EEEKGPVSP---RNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSST 584
Score = 415 bits (1067), Expect = e-116
Identities = 310/736 (42%), Positives = 384/736 (52%), Gaps = 104/736 (14%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL C T S
Sbjct: 1398 QRVGMAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLNRCYSTPSGYLELP 1457
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDR-----ESSHDGCQDALNILPVPGPTSSATNVSMV 198
D QP+ + + EE + +L VDR E D QD P P
Sbjct: 1458 DLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDEDQDP----PCPR----------- 1502
Query: 199 VSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQN 252
LS E E+ E+ L + + S C +C F A ++N
Sbjct: 1503 -----LSRELLEVVEPEV-------LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEN 1550
Query: 253 KYKYE----ECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREK 308
+ E + K R R+ K+E+ + K+ EE + S+E + E
Sbjct: 1551 HVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEV 1609
Query: 309 LREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDE 368
L++ D S L +P +S L++Q H+ + D DE
Sbjct: 1610 LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ---------HVGLAV------DMDE 1654
Query: 369 DVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKI 425
+ + E+ Q S PR E+ +E EV +DSL+ C T S D QP+
Sbjct: 1655 IEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVY 1714
Query: 426 TFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVP 482
+ EE + L + + D EEEE++GP PR L E E EV
Sbjct: 1715 SLEEQYLGLALD--------------VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVL 1760
Query: 483 QESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG----------------- 525
Q+S D YST S E+ S Q Y S+F++LEE V ++D+G
Sbjct: 1761 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSK 1820
Query: 526 --RHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRS 583
R R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRS
Sbjct: 1821 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRS 1880
Query: 584 AFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTP 643
AFYVLEQQ +GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTP
Sbjct: 1881 AFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTP 1940
Query: 644 SGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVE 703
SGYLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVE
Sbjct: 1941 SGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVE 2000
Query: 704 PEVLQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RG 757
PEVLQDSLD P L P F +N + F L +++++G RG
Sbjct: 2001 PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRG 2060
Query: 758 RKEGEEDQRRKEEGEE 773
R+ +E +R ++EGEE
Sbjct: 2061 RRSKKERRRGRKEGEE 2076
Score = 412 bits (1060), Expect = e-115
Identities = 303/724 (41%), Positives = 379/724 (52%), Gaps = 96/724 (13%)
Query: 92 DEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHK 150
D DE E Q VEED+ RE+ +E +V +DSL+ C T S D QP+
Sbjct: 1651 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1710
Query: 151 NIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAE 210
+ + EE + +L VDR ++ GP +
Sbjct: 1711 SAVYSLEEQYLGLALDVDRIKKDQEEEE---------------------DQGP-PCPRLS 1748
Query: 211 MNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQNKYKYE----ECK 260
+LE+ E L + + S C +C F A ++N + E +
Sbjct: 1749 RELLEVVEP--EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIE 1806
Query: 261 DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN 320
K R R+ K+E+ + K+ EE + S+E + E L++ D S
Sbjct: 1807 KKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTP 1865
Query: 321 EHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQK 380
L +P +S L++Q H+ + D DE + + E+ Q
Sbjct: 1866 SGCLELTDSCQPYRSAFYVLEQQ---------HVGLAV------DMDEIEKYQEVEEDQD 1910
Query: 381 SSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI 437
S PR E+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 1911 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD 1970
Query: 438 GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLS 494
+ + D EEEE++GP PR L E E EV Q+S D YST S
Sbjct: 1971 --------------VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPS 2016
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKE 535
E+ S Q Y S+F++LEE V ++D+G R R + +E
Sbjct: 2017 SCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2076
Query: 536 DQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGL 595
DQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQ +GL
Sbjct: 2077 DQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGL 2136
Query: 596 AVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 655
AVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQP
Sbjct: 2137 AVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 2196
Query: 656 YRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQ 715
Y SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD
Sbjct: 2197 YSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCY 2256
Query: 716 LLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKE 769
P L P F +N + F L +++++G RGR+ +E +R ++
Sbjct: 2257 STPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK 2316
Query: 770 EGEE 773
EGEE
Sbjct: 2317 EGEE 2320
Score = 412 bits (1060), Expect = e-115
Identities = 303/724 (41%), Positives = 379/724 (52%), Gaps = 96/724 (13%)
Query: 92 DEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHK 150
D DE E Q VEED+ RE+ +E +V +DSL+ C T S D QP+
Sbjct: 1895 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1954
Query: 151 NIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAE 210
+ + EE + +L VDR ++ GP +
Sbjct: 1955 SAVYSLEEQYLGLALDVDRIKKDQEEEE---------------------DQGP-PCPRLS 1992
Query: 211 MNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQNKYKYE----ECK 260
+LE+ E L + + S C +C F A ++N + E +
Sbjct: 1993 RELLEVVEP--EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIE 2050
Query: 261 DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN 320
K R R+ K+E+ + K+ EE + S+E + E L++ D S
Sbjct: 2051 KKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTP 2109
Query: 321 EHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQK 380
L +P +S L++Q H+ + D DE + + E+ Q
Sbjct: 2110 SGCLELTDSCQPYRSAFYVLEQQ---------HVGLAV------DMDEIEKYQEVEEDQD 2154
Query: 381 SSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI 437
S PR E+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 2155 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD 2214
Query: 438 GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLS 494
+ + D EEEE++GP PR L E E EV Q+S D YST S
Sbjct: 2215 --------------VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPS 2260
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKE 535
E+ S Q Y S+F++LEE V ++D+G R R + +E
Sbjct: 2261 SCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2320
Query: 536 DQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGL 595
DQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQ +GL
Sbjct: 2321 DQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGL 2380
Query: 596 AVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 655
AVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQP
Sbjct: 2381 AVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 2440
Query: 656 YRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQ 715
Y SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD
Sbjct: 2441 YSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCY 2500
Query: 716 LLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKE 769
P L P F +N + F L +++++G RGR+ +E +R ++
Sbjct: 2501 STPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK 2560
Query: 770 EGEE 773
EGEE
Sbjct: 2561 EGEE 2564
Score = 411 bits (1056), Expect = e-114
Identities = 308/745 (41%), Positives = 383/745 (51%), Gaps = 111/745 (14%)
Query: 92 DEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHK 150
D DE E Q VEED+ RE+ +E +V +DSL+ C T S D QP+
Sbjct: 2383 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2442
Query: 151 NIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAE 210
+ + EE + +L VDR ++ GP +
Sbjct: 2443 SAVYSLEEQYLGLALDVDRIKKDQEEEE---------------------DQGP-PCPRLS 2480
Query: 211 MNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQNKYKYE----ECK 260
+LE+ E L + + S C +C F A ++N + E +
Sbjct: 2481 RELLEVVEP--EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIE 2538
Query: 261 DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN 320
K R R+ K+E+ + K+ EE + S+E + E L++ D S
Sbjct: 2539 KKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTP 2597
Query: 321 EHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQK 380
L +P +S L++Q H+ + D DE + + E+ Q
Sbjct: 2598 SGCLELTDSCQPYRSAFYVLEQQ---------HVGLAV------DMDEIEKYQEVEEDQD 2642
Query: 381 SSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI 437
S PR E+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 2643 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD 2702
Query: 438 GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLS 494
+ + D EEEE++GP PR L E E EV Q+S D YST S
Sbjct: 2703 --------------VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPS 2748
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKE 535
E+ S Q Y S+F++LEE+ V ++D+G R R + +E
Sbjct: 2749 SCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2808
Query: 536 DQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGL 595
DQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQ +GL
Sbjct: 2809 DQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGL 2868
Query: 596 AVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 655
AVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQP
Sbjct: 2869 AVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 2928
Query: 656 YRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQ 715
Y SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD
Sbjct: 2929 YSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCY 2988
Query: 716 LLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG---------------RGRK 759
P L P F + + F L +++++G RGRK
Sbjct: 2989 STPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRK 3048
Query: 760 EGEEDQ-----RRKEEGEEKKGKKI 779
EGEEDQ R E ++KG K+
Sbjct: 3049 EGEEDQNPPCPRLSRELLDEKGPKV 3073
Score = 405 bits (1040), Expect = e-112
Identities = 316/835 (37%), Positives = 413/835 (49%), Gaps = 124/835 (14%)
Query: 5 STGRLPGQPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP------ 58
ST +P + Q Y HS E + Q+ + GR + + Q P
Sbjct: 566 STLSIPPEMLASYQSYSSTFHSLEEQ--QVCMAVDIGRHRWDQVKKEDQEATGPRLSREL 623
Query: 59 -DEPDKSQGQDLQE----------QLAEGC---RLAQHLV--QKLSPENDEDEDEDVQ-V 101
DE QD Q+ +L + C R A +++ Q++ D DE E Q V
Sbjct: 624 LDEKGPEVFQDSQDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAIDMDEIEKYQEV 683
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ +E +V +DSL+ C T S D QP+ + + EE +
Sbjct: 684 EEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL 743
Query: 162 NSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLC 221
+L VDR ++ GP + +LE+ E
Sbjct: 744 GLALDVDRIKKDQEEEE---------------------DQGP-PCPRLSRELLEVVE--- 778
Query: 222 PQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQ 281
P++ + ++C+ T +C + + C+ S E E+ +
Sbjct: 779 PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYGSSFYALE----EKHVGFS 821
Query: 282 LKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQ 341
L E ++ K R + R +EG + L L ++ + L
Sbjct: 822 LDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLD 881
Query: 342 E---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---E 386
+L + C R A +++++ D DE + + E+ Q S PR E
Sbjct: 882 RCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRE 941
Query: 387 MQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWE 446
+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 942 LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------- 992
Query: 447 DAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLASY 503
+ + D EEEE++GP PR L E E EV Q+S D YST S E+ S
Sbjct: 993 -----VDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 1047
Query: 504 QSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKEDQEATGPRL 544
Q Y S+F++LEE+ V ++D+G R R + +EDQ PRL
Sbjct: 1048 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1107
Query: 545 SRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEK 604
SRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+G AVDMDEIEK
Sbjct: 1108 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEK 1167
Query: 605 YQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLE 664
YQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLE
Sbjct: 1168 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 1227
Query: 665 EQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNS 723
EQYLGLALDVDRIKKD+EEEEDQ PPCPRLSRELLEVV PEVLQDSLD P L
Sbjct: 1228 EQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVAPEVLQDSLDRCYSTPSSCLEQ 1287
Query: 724 LTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 1288 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 1342
Score = 403 bits (1036), Expect = e-112
Identities = 306/800 (38%), Positives = 409/800 (51%), Gaps = 98/800 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPD---------EPDKSQ 65
+EI++Y+ + Q+ +L +L + ++ + + TP +P S
Sbjct: 2629 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2688
Query: 66 GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVP 125
L+EQ G L V ++ + +E+ED+ RE+ + E +V
Sbjct: 2689 VYSLEEQYL-GLALD---VDRIKKDQEEEEDQGPPCPR--------LSRELLEVVEPEVL 2736
Query: 126 EDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV 185
+DSL+ C T S+ DS QP+ + EE V SL V E G
Sbjct: 2737 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG-EIEKKG---------- 2785
Query: 186 PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEK------KQQFRSLKEKCF 239
G G E E CP+L+ + + + ++C+
Sbjct: 2786 KGKKRRGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKGPEVLQDSLDRCY 2838
Query: 240 VTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE 299
T C + C+ + E+Q LA + +E+ +Y+ + Q+
Sbjct: 2839 STPSGCLELT-------DSCQPYRSAFYVLEQQ--HVGLAVDM---DEIEKYQEVEEDQD 2886
Query: 300 RELTQLREKLREGRDASRSLNEHLQALLTPD---------EPDKSQGQDLQEQLAEGCRL 350
+L +L + ++ + + TP +P S L+EQ G L
Sbjct: 2887 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLAL 2945
Query: 351 AQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITC 407
++K D +++ED Q PR E+ + E EV +DSL+ C T
Sbjct: 2946 DVDRIKK-----DQEEEED---------QGPPCPRLSRELLEVVEPEVLQDSLDRCYSTP 2991
Query: 408 SNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEE 462
S+ DS QP+ + EE V +L + + ++ + E E
Sbjct: 2992 SSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGE 3051
Query: 463 EEKGPVSPRNLQESEEEEVP---QESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVC 519
E++ P PR +E +E+ P Q+S D YST S E S Q Y S F+ LE+Q+V
Sbjct: 3052 EDQNPPCPRLSRELLDEKGPKVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRVG 3111
Query: 520 MAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQ 579
+AVD+ Q +EDQ+ + PRLSRELLDEK PEVLQDSLDRCYSTPS L L DSCQ
Sbjct: 3112 LAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQ 3171
Query: 580 PYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRC 639
PYRSAFY+LEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRC
Sbjct: 3172 PYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 3231
Query: 640 YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 699
YSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL
Sbjct: 3232 YSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 3291
Query: 700 EVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG--- 755
EVVEPEVLQDSLD P L P F + + F L +++++G
Sbjct: 3292 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 3351
Query: 756 --RGRKEGEEDQRRKEEGEE 773
RGR+ +E +R ++EGEE
Sbjct: 3352 KRRGRRSKKERRRGRKEGEE 3371
Score = 398 bits (1023), Expect = e-111
Identities = 293/728 (40%), Positives = 377/728 (51%), Gaps = 102/728 (14%)
Query: 92 DEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHK 150
D DE E Q VEED+ RE+ +E +V +DSL+ C T S D QP+
Sbjct: 917 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 976
Query: 151 NIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAE 210
+ + EE + +L VDR ++ GP +
Sbjct: 977 SAVYSLEEQYLGLALDVDRIKKDQEEEE---------------------DQGP-PCPRLS 1014
Query: 211 MNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNE 270
+LE+ E P++ + ++C+ T +C + + C+ S E
Sbjct: 1015 RELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYGSSFYALE 1058
Query: 271 RQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPD 330
E+ + L E ++ K R + R +EG + L L +
Sbjct: 1059 ----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDE 1114
Query: 331 EPDKSQGQDLQE---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQVEVAEKV 378
+ + L +L + C R A +++++ D DE + + E+
Sbjct: 1115 KGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEED 1174
Query: 379 QKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST 435
Q S PR E+ +E EV +DSL+ C T S D QP+ + EE +
Sbjct: 1175 QDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLA 1234
Query: 436 LIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYST 492
L + + D+EEEE++ P PR L E EV Q+S D YST
Sbjct: 1235 LD--------------VDRIKKDEEEEEDQDPPCPRLSRELLEVVAPEVLQDSLDRCYST 1280
Query: 493 LSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVK 533
S E+ S Q Y S+F++LEE+ V ++D+G R R +
Sbjct: 1281 PSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEG 1340
Query: 534 KEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRI 593
+EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+
Sbjct: 1341 EEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRV 1400
Query: 594 GLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLG 653
G+AVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSL+RCYSTPSGYLELPDLG
Sbjct: 1401 GMAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLNRCYSTPSGYLELPDLG 1460
Query: 654 QPYRSAVYSLEEQYLGLALDVDRIKKDQEEE--EDQGPPCPRLSRELLEVVEPEVLQDSL 711
QPY SAVYSLEEQYLGLALDVDRIKKDQEEE EDQ PPCPRLSRELLEVVEPEVLQDSL
Sbjct: 1461 QPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDEDQDPPCPRLSRELLEVVEPEVLQDSL 1520
Query: 712 DVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQ 765
D P L P F +N + F L +++++G RGR+ +E +
Sbjct: 1521 DRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERR 1580
Query: 766 RRKEEGEE 773
R ++EGEE
Sbjct: 1581 RGRKEGEE 1588
Score = 360 bits (923), Expect = 4e-99
Identities = 287/794 (36%), Positives = 380/794 (47%), Gaps = 137/794 (17%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPD---------EPDKSQ 65
+EI++Y+ + Q+ +L +L + ++ + + TP +P S
Sbjct: 2873 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2932
Query: 66 GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVP 125
L+EQ G L V ++ + +E+ED+ RE+ + E +V
Sbjct: 2933 VYSLEEQYL-GLALD---VDRIKKDQEEEEDQGPPCPR--------LSRELLEVVEPEVL 2980
Query: 126 EDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV 185
+DSL+ C T S+ DS QP+ + EE V SL V E G
Sbjct: 2981 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG-EIEKKG---------- 3029
Query: 186 PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLK------EKCF 239
G G E E CP+L+ + + K ++C+
Sbjct: 3030 KGKKRRGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKGPKVLQDSLDRCY 3082
Query: 240 VTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE 299
T C E C R+ E++ +E+ +Y+ + Q+
Sbjct: 3083 STPSGCL----------ELCDSC--QPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQD 3130
Query: 300 RELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGC---RLAQHLVQ 356
+L +L + + + + TP +L + C R A ++++
Sbjct: 3131 PSCPRLSRELLDEKGPEVLQDSLDRCYSTPSGC---------LELCDSCQPYRSAFYILE 3181
Query: 357 KLSPENDNDDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGP 413
+ D DE + + E+ Q S PR E+ +E EV +DSL+ C T S
Sbjct: 3182 QQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLEL 3241
Query: 414 YDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR-- 471
D QP+ + EE + L + + D EEEE++GP PR
Sbjct: 3242 PDLGQPYSSAVYSLEEQYLGLALD--------------VDRIKKDQEEEEDQGPPCPRLS 3287
Query: 472 -NLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG----- 525
L E E EV Q+S D YST S E+ S Q Y S+F++LEE+ V ++D+G
Sbjct: 3288 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK 3347
Query: 526 --------------RHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVY 571
R R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS
Sbjct: 3348 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGC 3407
Query: 572 LGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEV 631
L L DSCQPYRSAFYVLEQQ +GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEV
Sbjct: 3408 LELCDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEV 3467
Query: 632 LQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD----------- 680
LQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD+I+K
Sbjct: 3468 LQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRS 3527
Query: 681 --------QEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPASPTEV 732
+E EEDQ PPCPRL+ L+EV E EVLQDSLD TP+ E+
Sbjct: 3528 KKERRRGRKEGEEDQNPPCPRLNGVLMEVEEREVLQDSLDRCY--------STPSMYFEL 3579
Query: 733 P--FMHWRKNMLAF 744
P F H+R +F
Sbjct: 3580 PDSFQHYRSVFYSF 3593
Score = 320 bits (821), Expect = 2e-87
Identities = 257/726 (35%), Positives = 352/726 (48%), Gaps = 100/726 (13%)
Query: 92 DEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHK 150
D DE E Q VEED+ RE+ +E +V +DSL+ C T S D QP+
Sbjct: 2871 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2930
Query: 151 NIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAE 210
+ + EE + +L VDR ++ GP +
Sbjct: 2931 SAVYSLEEQYLGLALDVDRIKKDQEEEE---------------------DQGP-PCPRLS 2968
Query: 211 MNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNE 270
+LE+ E P++ + ++C+ T +C + + C+ S E
Sbjct: 2969 RELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYGSSFYALE 3012
Query: 271 RQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPD 330
E+ + L E ++ K R + R +EG + L L +
Sbjct: 3013 ----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDE 3068
Query: 331 EPDKSQGQDLQE---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQVEVAEKV 378
+ K L +L + C R A +++++ D DE + + E+
Sbjct: 3069 KGPKVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEED 3128
Query: 379 QKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDST 435
Q S PR E+ + EV +DSL+ C T S DS QP+R E+ +V
Sbjct: 3129 QDPSCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYILEQQRVGLA 3188
Query: 436 LIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYST 492
+ + E E E EE++ P PR L + +E EV Q+S D YST
Sbjct: 3189 VD--------------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST 3234
Query: 493 LSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK 552
S E Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL+
Sbjct: 3235 PSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVV 3294
Query: 553 EPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY------- 605
EPEVLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 3295 EPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRR 3354
Query: 606 ------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLG 653
+E EEDQ+P CPRLSRELL EK PEVLQDSLDRCYSTPSG LEL D
Sbjct: 3355 GRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSC 3414
Query: 654 QPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDV 713
QPYRSA Y LE+Q++GLA+D+D I+K QE EEDQ P CPRLSRELL+ EPEVLQDSLD
Sbjct: 3415 QPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDR 3474
Query: 714 IQLLPVVLNSLTP-ASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRR 767
P L P + L L +K++++G RGR+ +E +R
Sbjct: 3475 CYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRSKKERRRG 3534
Query: 768 KEEGEE 773
++EGEE
Sbjct: 3535 RKEGEE 3540
Score = 303 bits (776), Expect = 4e-82
Identities = 271/803 (33%), Positives = 377/803 (46%), Gaps = 108/803 (13%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDAS---RSLNEHLQA----LLTPD--EPDKSQ 65
+EI++Y+ + Q+ +L +L + ++ SLN L PD +P S
Sbjct: 1407 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLNRCYSTPSGYLELPDLGQPYSSA 1466
Query: 66 GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVP 125
L+EQ G L ++K E +EDED+D RE+ + E +V
Sbjct: 1467 VYSLEEQYL-GLALDVDRIKK-DQEEEEDEDQDPPCPR--------LSRELLEVVEPEVL 1516
Query: 126 EDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV 185
+DSL+ C T S+ DS QP+ + EE+ V SL V E G
Sbjct: 1517 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVG-EIEKKG---------- 1565
Query: 186 PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEK------KQQFRSLKEKCF 239
G G E E CP+L+ + + + ++C+
Sbjct: 1566 KGKKRRGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKGPEVLQDSLDRCY 1618
Query: 240 VTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE 299
T C + C+ R+ E++ +E+ +Y+ + Q+
Sbjct: 1619 STPSGCLELT-------DSCQP-----YRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQD 1666
Query: 300 -------RELTQLREK--LREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRL 350
REL +E L++ D S L +P S L+EQ G L
Sbjct: 1667 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLAL 1725
Query: 351 AQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNS 410
++K D +++ED Q ++ RE+ + E EV +DSL+ C T S+
Sbjct: 1726 DVDRIKK-----DQEEEED-QGPPCPRLS-----RELLEVVEPEVLQDSLDRCYSTPSSC 1774
Query: 411 HGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEK 465
DS QP+ + EE+ V +L + + ++ + E EE++
Sbjct: 1775 LEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQ 1834
Query: 466 GPVSPRNLQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAV 522
P PR +E +E EV Q+S D YST S E S Q Y S F+ LE+Q V +AV
Sbjct: 1835 NPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAV 1894
Query: 523 DIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYR 582
D+ Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY
Sbjct: 1895 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 1954
Query: 583 SAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYST 642
SA Y LE+Q +GLA+D+D I+K QE EEDQ P CPRLSRELL EPEVLQDSLDRCYST
Sbjct: 1955 SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYST 2014
Query: 643 PSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEE 683
PS LE PD QPY S+ Y+LEE ++G +LDV I+K +E
Sbjct: 2015 PSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEG 2074
Query: 684 EEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA-SPTEVPFMHWRKNML 742
EEDQ PPCPRLSRELL+ PEVLQDSLD P LT + P F + +
Sbjct: 2075 EEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHV 2134
Query: 743 AFLLTWEKLKRRGRGRKEGEEDQ 765
+ +++++ +E EEDQ
Sbjct: 2135 GLAVDMDEIEK----YQEVEEDQ 2153
Score = 298 bits (763), Expect = 1e-80
Identities = 264/803 (32%), Positives = 375/803 (46%), Gaps = 110/803 (13%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPD---------EPDKSQ 65
+EI++Y+ + Q+ +L +L + ++ + + TP +P S
Sbjct: 2141 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2200
Query: 66 GQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVP 125
L+EQ G L V ++ + +E+ED+ RE+ + E +V
Sbjct: 2201 VYSLEEQYL-GLALD---VDRIKKDQEEEEDQGPPCPR--------LSRELLEVVEPEVL 2248
Query: 126 EDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV 185
+DSL+ C T S+ DS QP+ + EE+ V SL V E G
Sbjct: 2249 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVG-EIEKKG---------- 2297
Query: 186 PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEK------KQQFRSLKEKCF 239
G G E E CP+L+ + + + ++C+
Sbjct: 2298 KGKKRRGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKGPEVLQDSLDRCY 2350
Query: 240 VTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQE 299
T C + C+ R+ E++ +E+ +Y+ + Q+
Sbjct: 2351 STPSGCLELT-------DSCQP-----YRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQD 2398
Query: 300 -------RELTQLREK--LREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRL 350
REL +E L++ D S L +P S L+EQ G L
Sbjct: 2399 PSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL-GLAL 2457
Query: 351 AQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNS 410
++K D +++ED Q ++ RE+ + E EV +DSL+ C T S+
Sbjct: 2458 DVDRIKK-----DQEEEED-QGPPCPRLS-----RELLEVVEPEVLQDSLDRCYSTPSSC 2506
Query: 411 HGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEK 465
DS QP+ + EE+ V +L + + ++ + E EE++
Sbjct: 2507 LEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQ 2566
Query: 466 GPVSPRNLQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAV 522
P PR +E +E EV Q+S D YST S E S Q Y S F+ LE+Q V +AV
Sbjct: 2567 NPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAV 2626
Query: 523 DIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYR 582
D+ Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY
Sbjct: 2627 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 2686
Query: 583 SAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYST 642
SA Y LE+Q +GLA+D+D I+K QE EEDQ P CPRLSRELL EPEVLQDSLDRCYST
Sbjct: 2687 SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYST 2746
Query: 643 PSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEE 683
PS LE PD QPY S+ Y+LEE+++G +LDV I+K +E
Sbjct: 2747 PSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEG 2806
Query: 684 EEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA-SPTEVPFMHWRKNML 742
EEDQ PPCPRLSRELL+ PEVLQDSLD P LT + P F + +
Sbjct: 2807 EEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHV 2866
Query: 743 AFLLTWEKLKRRGRGRKEGEEDQ 765
+ +++++ +E EEDQ
Sbjct: 2867 GLAVDMDEIEK----YQEVEEDQ 2885
Score = 239 bits (611), Expect = 6e-63
Identities = 209/606 (34%), Positives = 291/606 (48%), Gaps = 83/606 (13%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ + KV +DSL+ C T S CDS QP+++ E+ +V
Sbjct: 3051 EEDQNPPCPRLSRELLDEKGPKVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRV 3110
Query: 162 NSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLC 221
++ +D + ++ + P+ + ++ GP + + ++ C
Sbjct: 3111 GLAVDMDEIEKYQEVEEDQD------PSCPRLSRELLDEKGPEVLQDS-LDRCYSTPSGC 3163
Query: 222 PQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY-KYEECK-DLIKSMLRNERQFKEEKLA 279
+L + Q +RS + Q LA ++ KY+E + D S R R+ +EK
Sbjct: 3164 LELCDSCQPYRSAFY--ILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEP 3221
Query: 280 EQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQD 339
E L+ + + R Y S EL L +P S
Sbjct: 3222 EVLQDSLD-RCYST--PSGYLELPDL------------------------GQPYSSAVYS 3254
Query: 340 LQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVP 396
L+EQ G L ++K D +++ED Q PR E+ + E EV
Sbjct: 3255 LEEQYL-GLALDVDRIKK-----DQEEEED---------QGPPCPRLSRELLEVVEPEVL 3299
Query: 397 EDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENE 456
+DSL+ C T S+ DS QP+ + EE V +L + + ++
Sbjct: 3300 QDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSK 3359
Query: 457 SD-----DEEEEEKGPVSPRNLQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSS 508
+ E EE++ P PR +E +E EV Q+S D YST S E S Q Y S
Sbjct: 3360 KERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRS 3419
Query: 509 TFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTP 568
F+ LE+Q V +AVD+ Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTP
Sbjct: 3420 AFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTP 3479
Query: 569 SVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY-------------------QEVE 609
S YL L D QPY SA Y LE+Q +GLA+D+D+IEK +E E
Sbjct: 3480 SGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRSKKERRRGRKEGE 3539
Query: 610 EDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLG 669
EDQ+P CPRL+ L+ +E EVLQDSLDRCYSTPS Y ELPD Q YRS YS EEQ++
Sbjct: 3540 EDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHIS 3599
Query: 670 LALDVD 675
AL VD
Sbjct: 3600 FALYVD 3605
>gi|83415174 hypothetical protein LOC400818 [Homo sapiens]
Length = 942
Score = 1318 bits (3412), Expect = 0.0
Identities = 678/765 (88%), Positives = 704/765 (92%), Gaps = 6/765 (0%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQERELTQL+EKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 90 EELRQYKVLVHSQERELTQLKEKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLES APREVQKAEESKV EDSLEECAI
Sbjct: 150 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESPAPREVQKAEESKVTEDSLEECAI 209
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194
TCSNSHGPCDS QPHKNIKITFEED+VNS+LVVDRESSHD CQDALNILPVPGPTSSATN
Sbjct: 210 TCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNILPVPGPTSSATN 269
Query: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKY 254
VSMVVSAGPLSSEKAEMNILEINEKL PQLAEKKQQFR+LKEKCF+TQ+A FLA QQNKY
Sbjct: 270 VSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANQQNKY 329
Query: 255 KYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD 314
KYEECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRD
Sbjct: 330 KYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRD 389
Query: 315 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374
ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDD+EDVQVEV
Sbjct: 390 ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDNEDVQVEV 449
Query: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDS 434
AEKVQKSS+PREMQKAEEKEVPEDSLEECAIT SNSHGPYDSNQPHRKTKITFEEDKVDS
Sbjct: 450 AEKVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDS 509
Query: 435 TLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLS 494
TLIGSSSHVE EDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYST S
Sbjct: 510 TLIGSSSHVEREDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTPS 569
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554
IPPE LASY+SYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK P
Sbjct: 570 IPPEMLASYKSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGP 629
Query: 555 EVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 614
EVLQDSL RCYSTPS L LTDSCQPYRSAFYVLEQQR+GLAVDMDEIEKYQEVEEDQDP
Sbjct: 630 EVLQDSLYRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDP 689
Query: 615 SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDV 674
SCPRLSRELL EKEPEVLQDSL R YSTPSGY ELPDLGQPY SAVYSLEEQYLGLALD+
Sbjct: 690 SCPRLSRELLDEKEPEVLQDSLGRWYSTPSGYPELPDLGQPYSSAVYSLEEQYLGLALDL 749
Query: 675 DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPV-VLNSLTPASPTEVP 733
DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L P
Sbjct: 750 DRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSWQPYGSS 809
Query: 734 FMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 810 FYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 854
Score = 447 bits (1151), Expect = e-125
Identities = 287/569 (50%), Positives = 359/569 (63%), Gaps = 60/569 (10%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
MVVSAGP SSEKAEMNILEINEKL PQLAE KQQF +LKE+CF+TQ+A FLA +Q KYKY
Sbjct: 1 MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFGNLKERCFLTQLAGFLANRQKKYKY 60
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316
EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQL+EKLREGRDAS
Sbjct: 61 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDAS 120
Query: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376
RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND D+DEDVQVE E
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDE 180
Query: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436
KV +S +PRE+QKAEE +V EDSLEECAITCSNSHGP DSNQPH+ KITFEED+V+STL
Sbjct: 181 KVLESPAPREVQKAEESKVTEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 240
Query: 437 I--GSSSHVEWEDAVHIIP-----ENESDDEEEEEKGPVSPR----NLQESEEEEVPQES 485
+ SSH E +DA++I+P + ++ GP+S N+ E E+ PQ +
Sbjct: 241 VVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLA 300
Query: 486 WDEGYSTLSIPPE----RLASYQSYSSTFHSLEEQQVCMAVDIGRHRW---DQVKKEDQE 538
++ ++ + +LA + + + EE + + + R +++ ++ ++
Sbjct: 301 -EKKQQFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQ 359
Query: 539 ATGPRLSRELLDEKEPEV------LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQ-- 590
A R + L+ +E E+ L++ D S L +P +S L++
Sbjct: 360 AEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQL 419
Query: 591 -----------QRIGLAVDMDEIEKYQ--EVEEDQDPSCPRLSRELLAEKEPEVLQDSLD 637
Q++ D D+ E Q E+ Q S P RE+ +E EV +DSL+
Sbjct: 420 AEGCRLAQHLVQKLSPENDNDDNEDVQVEVAEKVQKSSAP---REMQKAEEKEVPEDSLE 476
Query: 638 RCYSTPSGYLELPDLGQPYRSAVYSLEEQ-----YLGLALDVDR---------IKKDQEE 683
C T S D QP+R + EE +G + V+R + D EE
Sbjct: 477 ECAITYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEREDAVHIIPENESDDEE 536
Query: 684 EEDQGPPCPRLSRELLEVVEPEVLQDSLD 712
EE++GP P R L E E EV Q+S D
Sbjct: 537 EEEKGPVSP---RNLQESEEEEVPQESWD 562
Score = 223 bits (569), Expect = 4e-58
Identities = 144/328 (43%), Positives = 186/328 (56%), Gaps = 39/328 (11%)
Query: 373 EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429
+V ++ Q+++ PR E+ + EV +DSL C T S DS QP+R E+
Sbjct: 606 QVKKEDQEATGPRLSRELLDEKGPEVLQDSLYRCYSTPSGCLELTDSCQPYRSAFYVLEQ 665
Query: 430 DKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESW 486
+V + + E E E EE++ P PR L + +E EV Q+S
Sbjct: 666 QRVGLAVD--------------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSL 711
Query: 487 DEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSR 546
YST S PE Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSR
Sbjct: 712 GRWYSTPSGYPELPDLGQPYSSAVYSLEEQYLGLALDLDRIKKDQEEEEDQGPPCPRLSR 771
Query: 547 ELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY- 605
ELL+ EPEVLQDSLDRCYSTPS L DS QPY S+FY LE++ +G ++D+ EIEK
Sbjct: 772 ELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSWQPYGSSFYALEEKHVGFSLDVGEIEKKG 831
Query: 606 ------------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYL 647
+E EEDQ+P CPRL+ L+ +EPEVLQDSLD CYSTPS Y
Sbjct: 832 KGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEPEVLQDSLDGCYSTPSMYF 891
Query: 648 ELPDLGQPYRSAVYSLEEQYLGLALDVD 675
ELPD Q YRS YS EEQ++ AL VD
Sbjct: 892 ELPDSFQHYRSVFYSFEEQHISFALYVD 919
Score = 33.9 bits (76), Expect = 0.60
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 116 VQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVD 168
+ + EE +V +DSL+ C T S DS Q ++++ +FEE ++ +L VD
Sbjct: 867 LMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVD 919
>gi|169162915 PREDICTED: hypothetical protein LOC728841 [Homo
sapiens]
Length = 3815
Score = 1023 bits (2646), Expect = 0.0
Identities = 525/596 (88%), Positives = 543/596 (91%), Gaps = 6/596 (1%)
Query: 184 PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQV 243
PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKL PQLAEKKQQFR+LKE+CFVTQ+
Sbjct: 8 PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLHPQLAEKKQQFRNLKERCFVTQL 67
Query: 244 ACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 303
A FLA QQ KYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELT
Sbjct: 68 AGFLANQQKKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELT 127
Query: 304 QLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 363
QLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND
Sbjct: 128 QLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 187
Query: 364 NDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKT 423
NDDDEDVQVE+AEKVQKSS+PREMQKAEEKEVPEDS EECAIT SNSHGPYDSNQPHRKT
Sbjct: 188 NDDDEDVQVELAEKVQKSSAPREMQKAEEKEVPEDSQEECAITYSNSHGPYDSNQPHRKT 247
Query: 424 KITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ 483
KITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ
Sbjct: 248 KITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ 307
Query: 484 ESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPR 543
ESWDEGYSTLSIPPE LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPR
Sbjct: 308 ESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPR 367
Query: 544 LSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIE 603
LSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQRIGLAVDMDEIE
Sbjct: 368 LSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRIGLAVDMDEIE 427
Query: 604 KYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSL 663
KYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSL
Sbjct: 428 KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSL 487
Query: 664 EEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLN 722
EEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L
Sbjct: 488 EEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLE 547
Query: 723 SLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 548 QPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 603
Score = 649 bits (1673), Expect = 0.0
Identities = 409/800 (51%), Positives = 485/800 (60%), Gaps = 103/800 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVH+QERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 110 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 169
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPEND D+DEDVQVE EKV +SSAPRE+QKAEE +VPEDS EECAI
Sbjct: 170 EGCRLAQHLVQKLSPENDNDDDEDVQVELAEKVQKSSAPREMQKAEEKEVPEDSQEECAI 229
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV--------- 185
T SNSHGP DS QPH+ KITFEEDKV+S+L+ SSH +DA++I+P
Sbjct: 230 TYSNSHGPYDSNQPHRKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 287
Query: 186 -PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVA 244
GP S P S + L I ++ F SL+E Q
Sbjct: 288 EKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEE-----QQV 342
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C +A ++++++ K KE++ A + + EL K
Sbjct: 343 C-MAVDIGRHRWDQVK-------------KEDQEATGPRLSRELLDEKG----------- 377
Query: 305 LREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN 364
E L++ D S L +P +S L++Q R+ +
Sbjct: 378 -PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQ-----RIGLAV---------- 421
Query: 365 DDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 421
D DE + + E+ Q S PR E+ +E EV +DSL+ C T S D QP+
Sbjct: 422 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 481
Query: 422 KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEE 478
+ EE + L + + D EEEE++GP PR L E E
Sbjct: 482 SAVYSLEEQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVE 527
Query: 479 EEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG------------- 525
EV Q+S D YST S E+ S Q Y S+F++LEE+ V ++D+G
Sbjct: 528 PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 587
Query: 526 ------RHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQ 579
R R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQ
Sbjct: 588 RRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQ 647
Query: 580 PYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRC 639
PYRSAFYVLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRC
Sbjct: 648 PYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRC 707
Query: 640 YSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELL 699
YSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELL
Sbjct: 708 YSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELL 767
Query: 700 EVVEPEVLQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG--- 755
EVVEPEVLQDSLD P L P F + + F L +++++G
Sbjct: 768 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 827
Query: 756 --RGRKEGEEDQRRKEEGEE 773
RGR+ +E +R ++EGEE
Sbjct: 828 KRRGRRSKKERRRGRKEGEE 847
Score = 413 bits (1061), Expect = e-115
Identities = 300/733 (40%), Positives = 383/733 (52%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 1898 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 1957
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 1958 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 1996
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 1997 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 2039
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 2040 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 2095
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+S +L + C R A +++++ D DE +
Sbjct: 2096 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 2155
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 2156 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 2215
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 2216 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 2261
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 2262 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 2321
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFY
Sbjct: 2322 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFY 2381
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 2382 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 2441
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 2442 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 2501
Query: 707 LQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 2502 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 2561
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 2562 KKERRRGRKEGEE 2574
Score = 407 bits (1046), Expect = e-113
Identities = 298/733 (40%), Positives = 381/733 (51%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 1654 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 1713
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 1714 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 1752
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 1753 -PCPRLSRELLEVVE---PEVLQDS------LDRCYSTPSSCL-------EQPDSCQPYG 1795
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRD--------A 315
S E E+ + L E ++ K R + R +EG +
Sbjct: 1796 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1851
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
SR L + + D D+ +L + C R A +++++ D DE +
Sbjct: 1852 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 1911
Query: 372 VEVAEKVQKSSSP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S P RE+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 1912 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 1971
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP---RNLQESEEEEVPQES 485
E + L + + D EEEE++GP P R L E E EV Q+S
Sbjct: 1972 EQYLGLAL--------------DVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 2017
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 2018 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 2077
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEK PEVLQDSLDR YSTPS L LTDSCQPYRSAFY
Sbjct: 2078 RRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFY 2137
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
VLEQQR+GLAVDMDEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 2138 VLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 2197
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 2198 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 2257
Query: 707 LQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 2258 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 2317
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 2318 KKERRRGRKEGEE 2330
Score = 406 bits (1043), Expect = e-113
Identities = 290/715 (40%), Positives = 371/715 (51%), Gaps = 99/715 (13%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ +E +V +DSL+ C T S D QP+ + + EE +
Sbjct: 1428 EEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL 1487
Query: 162 NSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLC 221
+L VDR ++ GP + +LE+ E
Sbjct: 1488 GLALDVDRTKKDQEEEE---------------------DQGP-PCPRLSRELLEVVE--- 1522
Query: 222 PQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQ 281
P++ + ++C+ T +C + + C+ S E E+ +
Sbjct: 1523 PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYGSSFYALE----EKHVGFS 1565
Query: 282 LKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQ 341
L E ++ K R + R +EG + L L ++ + L
Sbjct: 1566 LDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLD 1625
Query: 342 E---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---E 386
+L + C R A +++++ D DE + + E+ Q S PR E
Sbjct: 1626 RCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRE 1685
Query: 387 MQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWE 446
+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 1686 LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------- 1736
Query: 447 DAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLASY 503
+ + D EEEE++GP PR L E E EV Q+S D YST S E+ S
Sbjct: 1737 -----VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 1791
Query: 504 QSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKEDQEATGPRL 544
Q Y S+F++LEE+ V ++D+G R R + +EDQ PRL
Sbjct: 1792 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1851
Query: 545 SRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEK 604
SRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+GLAVDMDEIEK
Sbjct: 1852 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 1911
Query: 605 YQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLE 664
YQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLE
Sbjct: 1912 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 1971
Query: 665 EQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNS 723
EQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L
Sbjct: 1972 EQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 2031
Query: 724 LTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 2032 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2086
Score = 398 bits (1022), Expect = e-110
Identities = 234/417 (56%), Positives = 269/417 (64%), Gaps = 42/417 (10%)
Query: 385 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 444
RE+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 2585 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD------- 2637
Query: 445 WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLA 501
+ + D EEEE++GP PR L E E EV Q+S D YST S E+
Sbjct: 2638 -------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPD 2690
Query: 502 SYQSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKEDQEATGP 542
S Q Y S+F++LEE+ V ++D+G R R + +EDQ P
Sbjct: 2691 SCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCP 2750
Query: 543 RLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEI 602
RLSRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+GLAVDMDEI
Sbjct: 2751 RLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEI 2810
Query: 603 EKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 662
EKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYS
Sbjct: 2811 EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS 2870
Query: 663 LEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVL 721
LEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L
Sbjct: 2871 LEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL 2930
Query: 722 NSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 2931 EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2987
Score = 394 bits (1012), Expect = e-109
Identities = 289/733 (39%), Positives = 375/733 (51%), Gaps = 100/733 (13%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 415 QRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 474
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 475 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 513
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLI 263
+ +LE+ E P++ + ++C+ T +C + + C+
Sbjct: 514 -PCPRLSRELLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYG 556
Query: 264 KSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHL 323
S E E+ + L E ++ K R + R +EG + L
Sbjct: 557 SSFYALE----EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 612
Query: 324 QALLTPDEPDKSQGQDLQE---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQ 371
L ++ + L +L + C R A +++++ D DE +
Sbjct: 613 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 672
Query: 372 VEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q S PR E+ +E EV +DSL+ C T S D QP+ + E
Sbjct: 673 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 732
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQES 485
E + L + + D EEEE++GP PR L E E EV Q+S
Sbjct: 733 EQYLGLALD--------------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 778
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------R 526
D YST S E+ S Q Y S+F++LEE+ V ++D+G R
Sbjct: 779 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 838
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
R + +EDQ PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY SA Y
Sbjct: 839 RRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVY 898
Query: 587 VLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGY 646
LE+Q +GLA+D+DEIEKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGY
Sbjct: 899 SLEEQYLGLALDVDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGY 958
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEV 706
LELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEV
Sbjct: 959 LELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEV 1018
Query: 707 LQDSLDVIQLLP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKE 760
LQDSLD P L P F + + F L +++++G RGR+
Sbjct: 1019 LQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRS 1078
Query: 761 GEEDQRRKEEGEE 773
+E +R ++EGEE
Sbjct: 1079 KKERRRGRKEGEE 1091
Score = 394 bits (1012), Expect = e-109
Identities = 233/417 (55%), Positives = 268/417 (64%), Gaps = 42/417 (10%)
Query: 385 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 444
RE+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 3336 RELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD------- 3388
Query: 445 WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLA 501
+ + D EEEE++GP PR L E E EV Q+S D YST S E+
Sbjct: 3389 -------VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPD 3441
Query: 502 SYQSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKEDQEATGP 542
S Q Y S+F++LEE+ V ++D+G R R + +EDQ P
Sbjct: 3442 SCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCP 3501
Query: 543 RLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEI 602
RLSRELLDEK PEVLQDSLDR YSTPS L LTDSCQPYRSAFYVLEQQR+GLAVDMDEI
Sbjct: 3502 RLSRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEI 3561
Query: 603 EKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 662
EKYQEVEEDQDPSCPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYS
Sbjct: 3562 EKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS 3621
Query: 663 LEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVL 721
LEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L
Sbjct: 3622 LEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL 3681
Query: 722 NSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 3682 EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 3738
Score = 362 bits (928), Expect = e-99
Identities = 281/736 (38%), Positives = 370/736 (50%), Gaps = 87/736 (11%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 2799 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 2858
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGP 203
D QP+ + + EE + +L VDR ++ GP
Sbjct: 2859 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP 2897
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQNKYKYE 257
+ +LE+ E L + + S C +C F A ++ +
Sbjct: 2898 -PCPRLSRELLEVVEP--EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFS 2954
Query: 258 ----ECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGR 313
E + K R R+ K+E+ + K+ EE + S+E + E L++
Sbjct: 2955 LDVGEIEKKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKEPEVLQDSL 3013
Query: 314 DASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVE 373
D S L +P S L+EQ +L L + D E+
Sbjct: 3014 DRCYSTPSGYLELPDLGQPYSSAVYSLEEQ---------YLGLALDVDRTKKDQEE---- 3060
Query: 374 VAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEED 430
E+ Q PR E+ + E EV +DSL+ C T S+ DS QP+ + EE
Sbjct: 3061 --EEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEK 3118
Query: 431 KVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPR---NLQESEEEEVP 482
V +L + + ++ + E EE++ P PR L + +E EV
Sbjct: 3119 HVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVL 3178
Query: 483 QESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGP 542
Q+S D YST S E Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ P
Sbjct: 3179 QDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCP 3238
Query: 543 RLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEI 602
RLSRELL+ EPEVLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EI
Sbjct: 3239 RLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEI 3298
Query: 603 EKY-------------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTP 643
EK +E EEDQ+P CPRLSRELL EKEPEVLQDSLDRCYSTP
Sbjct: 3299 EKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTP 3358
Query: 644 SGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVE 703
SGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVE
Sbjct: 3359 SGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVE 3418
Query: 704 PEVLQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RG 757
PEVLQDSLD P L P F + + F L +++++G RG
Sbjct: 3419 PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 3478
Query: 758 RKEGEEDQRRKEEGEE 773
R+ +E +R ++EGEE
Sbjct: 3479 RRSKKERRRGRKEGEE 3494
Score = 361 bits (927), Expect = 1e-99
Identities = 280/729 (38%), Positives = 367/729 (50%), Gaps = 87/729 (11%)
Query: 92 DEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHK 150
D DE E Q VEED+ RE+ +E +V +DSL+ C T S D QP+
Sbjct: 910 DVDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYS 969
Query: 151 NIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAE 210
+ + EE + +L VDR ++ GP +
Sbjct: 970 SAVYSLEEQYLGLALDVDRTKKDQEEEE---------------------DQGP-PCPRLS 1007
Query: 211 MNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQNKYKYE----ECK 260
+LE+ E L + + S C +C F A ++ + E +
Sbjct: 1008 RELLEVVEP--EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIE 1065
Query: 261 DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLN 320
K R R+ K+E+ + K+ EE + S+E + E L++ D S
Sbjct: 1066 KKGKGKKRRGRRSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTP 1124
Query: 321 EHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQK 380
L +P S L+EQ +L L + D E+ E+ Q
Sbjct: 1125 SGYLELPDLGQPYSSAVYSLEEQ---------YLGLALDVDRTKKDQEE------EEDQG 1169
Query: 381 SSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI 437
PR E+ + E EV +DSL+ C T S+ DS QP+ + EE V +L
Sbjct: 1170 PPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLD 1229
Query: 438 GSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPR---NLQESEEEEVPQESWDEG 489
+ + ++ + E EE++ P PR L + +E EV Q+S D
Sbjct: 1230 VGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRC 1289
Query: 490 YSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELL 549
YST S E Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL
Sbjct: 1290 YSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELL 1349
Query: 550 DEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---- 605
+ EPEVLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 1350 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 1409
Query: 606 ---------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELP 650
+E EEDQ+P CPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELP
Sbjct: 1410 KRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 1469
Query: 651 DLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 710
DLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS
Sbjct: 1470 DLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 1529
Query: 711 LDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEED 764
LD P L P F + + F L +++++G RGR+ +E
Sbjct: 1530 LDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKER 1589
Query: 765 QRRKEEGEE 773
+R ++EGEE
Sbjct: 1590 RRGRKEGEE 1598
Score = 361 bits (926), Expect = 2e-99
Identities = 289/809 (35%), Positives = 395/809 (48%), Gaps = 97/809 (11%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 668 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 727
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 728 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 780
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTS 190
C T S+ DS QP+ + EE V SL V E G G
Sbjct: 781 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG-EIEKKG----------KGKKR 829
Query: 191 SATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLA------EKKQQFRSLKEKCFVTQVA 244
G E E CP+L+ ++ + + ++C+ T
Sbjct: 830 RGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 882
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
Y E DL + +E+ L L +E+ +Y+ + Q+ +
Sbjct: 883 -----------YLELPDLGQPYSSAVYSLEEQYLGLAL-DVDEIEKYQEVEEDQDPSCPR 930
Query: 305 LREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
L +L + ++ + + TP + PD Q E Q+L L
Sbjct: 931 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE----EQYLGLALDV 986
Query: 361 ENDNDDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSN 417
+ D E+ E+ Q PR E+ + E EV +DSL+ C T S+ DS
Sbjct: 987 DRTKKDQEE------EEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 1040
Query: 418 QPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPR- 471
QP+ + EE V +L + + ++ + E EE++ P PR
Sbjct: 1041 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 1100
Query: 472 --NLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW 529
L + +E EV Q+S D YST S E Q YSS +SLEEQ + +A+D+ R +
Sbjct: 1101 SRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKK 1160
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
DQ ++EDQ PRLSRELL+ EPEVLQDSLDRCYSTPS L DSCQPY S+FY LE
Sbjct: 1161 DQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALE 1220
Query: 590 QQRIGLAVDMDEIEKY-------------------QEVEEDQDPSCPRLSRELLAEKEPE 630
++ +G ++D+ EIEK +E EEDQ+P CPRLSRELL EKEPE
Sbjct: 1221 EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPE 1280
Query: 631 VLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPP 690
VLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPP
Sbjct: 1281 VLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPP 1340
Query: 691 CPRLSRELLEVVEPEVLQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAFLLTWE 749
CPRLSRELLEVVEPEVLQDSLD P L P F + + F L
Sbjct: 1341 CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG 1400
Query: 750 KLKRRG-----RGRKEGEEDQRRKEEGEE 773
+++++G RGR+ +E +R ++EGEE
Sbjct: 1401 EIEKKGKGKKRRGRRSKKERRRGRKEGEE 1429
Score = 358 bits (918), Expect = 1e-98
Identities = 271/723 (37%), Positives = 361/723 (49%), Gaps = 86/723 (11%)
Query: 97 EDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITF 156
+D + EED+ RE+ + E +V +DSL+ C T S+ DS QP+ +
Sbjct: 2643 KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYAL 2702
Query: 157 EEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEI 216
EE V SL V E G G G E E
Sbjct: 2703 EEKHVGFSLDVG-EIEKKG----------KGKKRRGRRSKKERRRGRKEGE-------ED 2744
Query: 217 NEKLCPQLAEK------KQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNE 270
CP+L+ + + + ++C+ T C + C+ R+
Sbjct: 2745 QNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELT-------DSCQPY-----RSA 2792
Query: 271 RQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP- 329
E++ +E+ +Y+ + Q+ +L +L + ++ + + TP
Sbjct: 2793 FYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPS 2852
Query: 330 ---DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR- 385
+ PD Q E Q+L L + D E+ E+ Q PR
Sbjct: 2853 GYLELPDLGQPYSSAVYSLE----EQYLGLALDVDRTKKDQEE------EEDQGPPCPRL 2902
Query: 386 --EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHV 443
E+ + E EV +DSL+ C T S+ DS QP+ + EE V +L
Sbjct: 2903 SRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEK 2962
Query: 444 EWEDAVHIIPENESD-----DEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSI 495
+ + ++ + E EE++ P PR L + +E EV Q+S D YST S
Sbjct: 2963 KGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSG 3022
Query: 496 PPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPE 555
E Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL+ EPE
Sbjct: 3023 YLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPE 3082
Query: 556 VLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---------- 605
VLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 3083 VLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRR 3142
Query: 606 ---------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY 656
+E EEDQ+P CPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY
Sbjct: 3143 SKKERRRGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPY 3202
Query: 657 RSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQL 716
SAVYSLEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD
Sbjct: 3203 SSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYS 3262
Query: 717 LP-VVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEE 770
P L P F + + F L +++++G RGR+ +E +R ++E
Sbjct: 3263 TPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKE 3322
Query: 771 GEE 773
GEE
Sbjct: 3323 GEE 3325
Score = 351 bits (901), Expect = 1e-96
Identities = 213/417 (51%), Positives = 257/417 (61%), Gaps = 42/417 (10%)
Query: 385 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 444
RE+ + EV +DSL+ C T S DS QP+R E+ +V +
Sbjct: 2341 RELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVD------- 2393
Query: 445 WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLA 501
+ E E E EE++ P PR L + +E EV Q+S D YST S E
Sbjct: 2394 -------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD 2446
Query: 502 SYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSL 561
Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL+ EPEVLQDSL
Sbjct: 2447 LGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSL 2506
Query: 562 DRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---------------- 605
DRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 2507 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERR 2566
Query: 606 ---QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 662
+E EEDQ+P CPRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYS
Sbjct: 2567 RGRKEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYS 2626
Query: 663 LEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPV-VL 721
LEEQYLGLALDVDR KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L
Sbjct: 2627 LEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL 2686
Query: 722 NSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
P F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 2687 EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 2743
Score = 296 bits (759), Expect = 4e-80
Identities = 259/796 (32%), Positives = 368/796 (46%), Gaps = 96/796 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 1663 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 1722
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 1723 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 1775
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTS 190
C T S+ DS QP+ + EE V SL V E G G
Sbjct: 1776 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVG-EIEKKG----------KGKKR 1824
Query: 191 SATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEK------KQQFRSLKEKCFVTQVA 244
G E E CP+L+ + + + ++C+ T
Sbjct: 1825 RGRRSKKERRRGRKEGE-------EDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSG 1877
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C + C+ R+ E++ +E+ +Y+ + Q+ +
Sbjct: 1878 CLELT-------DSCQP-----YRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPR 1925
Query: 305 LREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 360
L +L + ++ + + TP + PD Q E Q+L L
Sbjct: 1926 LSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE----EQYLGLALDV 1981
Query: 361 ENDNDDDEDVQVEVAEKVQKSSSP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSN 417
+ D E+ E+ Q P RE+ + E EV +DSL+ C T S+ DS
Sbjct: 1982 DRTKKDQEE------EEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 2035
Query: 418 QPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRN 472
QP+ + EE V +L + + ++ + E EE++ P PR
Sbjct: 2036 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 2095
Query: 473 LQESEEE---EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW 529
+E +E EV Q+S D YST S E S Q Y S F+ LE+Q+V +AVD+
Sbjct: 2096 SRELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEK 2155
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
Q +EDQ+ + PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY SA Y LE
Sbjct: 2156 YQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLE 2215
Query: 590 QQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLEL 649
+Q +GLA+D+D +K QE EEDQ P CPRLSRELL EPEVLQDSLDRCYSTPS LE
Sbjct: 2216 EQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQ 2275
Query: 650 PDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQGPP 690
PD QPY S+ Y+LEE+++G +LDV I+K +E EEDQ PP
Sbjct: 2276 PDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPP 2335
Query: 691 CPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA-SPTEVPFMHWRKNMLAFLLTWE 749
CPRLSRELL+ PEVLQDSLD P LT + P F + + + +
Sbjct: 2336 CPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 2395
Query: 750 KLKRRGRGRKEGEEDQ 765
++++ +E EEDQ
Sbjct: 2396 EIEK----YQEVEEDQ 2407
Score = 293 bits (749), Expect = 6e-79
Identities = 237/651 (36%), Positives = 316/651 (48%), Gaps = 80/651 (12%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ +E +V +DSL+ C T S D QP+ + + EE +
Sbjct: 3155 EEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL 3214
Query: 162 NSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLC 221
+L VDR ++ GP + +LE+ E
Sbjct: 3215 GLALDVDRTKKDQEEEE---------------------DQGP-PCPRLSRELLEVVEP-- 3250
Query: 222 PQLAEKKQQFRSLKEKCFVTQVAC------FLAKQQNKYKYE----ECKDLIKSMLRNER 271
L + + S C +C F A ++ + E + K R R
Sbjct: 3251 EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGR 3310
Query: 272 QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDE 331
+ K+E+ + K+ EE + S+E + E L++ D S L +
Sbjct: 3311 RSKKERRRGR-KEGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQ 3369
Query: 332 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---EMQ 388
P S L+EQ +L L + D E+ E+ Q PR E+
Sbjct: 3370 PYSSAVYSLEEQ---------YLGLALDVDRTKKDQEE------EEDQGPPCPRLSRELL 3414
Query: 389 KAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDA 448
+ E EV +DSL+ C T S+ DS QP+ + EE V +L + +
Sbjct: 3415 EVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGK 3474
Query: 449 VHIIPENESD-----DEEEEEKGPVSPRNLQESEEE---EVPQESWDEGYSTLSIPPERL 500
++ + E EE++ P PR +E +E EV Q+S D YST S E
Sbjct: 3475 KRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRSYSTPSGCLELT 3534
Query: 501 ASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDS 560
S Q Y S F+ LE+Q+V +AVD+ Q +EDQ+ + PRLSRELLDEKEPEVLQDS
Sbjct: 3535 DSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDS 3594
Query: 561 LDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLS 620
LDRCYSTPS YL L D QPY SA Y LE+Q +GLA+D+D +K QE EEDQ P CPRLS
Sbjct: 3595 LDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLS 3654
Query: 621 RELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD 680
RELL EPEVLQDSLDRCYSTPS LE PD QPY S+ Y+LEE+++G +LDV I+K
Sbjct: 3655 RELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKK 3714
Query: 681 -------------------QEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD 712
+E EEDQ PPCPRLSRELL+ PEVLQDSLD
Sbjct: 3715 GKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLD 3765
Score = 238 bits (608), Expect = 1e-62
Identities = 149/313 (47%), Positives = 185/313 (59%), Gaps = 36/313 (11%)
Query: 385 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 444
RE+ + EV +DSL+ T S DS QP+R E+ +V +
Sbjct: 3505 RELLDEKGPEVLQDSLDRSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVD------- 3557
Query: 445 WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLA 501
+ E E E EE++ P PR L + +E EV Q+S D YST S E
Sbjct: 3558 -------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPD 3610
Query: 502 SYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSL 561
Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL+ EPEVLQDSL
Sbjct: 3611 LGQPYSSAVYSLEEQYLGLALDVDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSL 3670
Query: 562 DRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY---------------- 605
DRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 3671 DRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERR 3730
Query: 606 ---QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYS 662
+E EEDQ+P CPRLSRELL EK PEVLQDSLDRCYSTPSG LEL D QPYRSA Y
Sbjct: 3731 RGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYV 3790
Query: 663 LEEQYLGLALDVD 675
LE+Q +GLA+D+D
Sbjct: 3791 LEQQRVGLAVDMD 3803
Score = 178 bits (452), Expect = 2e-44
Identities = 168/536 (31%), Positives = 237/536 (44%), Gaps = 93/536 (17%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ +E +V +DSL+ C T S D QP+ + + EE +
Sbjct: 3324 EEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL 3383
Query: 162 NSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLC 221
+L VDR ++ GP + +LE+ E
Sbjct: 3384 GLALDVDRTKKDQEEEE---------------------DQGP-PCPRLSRELLEVVE--- 3418
Query: 222 PQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQ 281
P++ + ++C+ T +C + + C+ S E E+ +
Sbjct: 3419 PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYGSSFYALE----EKHVGFS 3461
Query: 282 LKQAEELRQYKVLVHSQERELTQLREKLREGRD--------ASRSLNEHLQALLTPDEPD 333
L E ++ K R + R +EG + SR L + + D D
Sbjct: 3462 LDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLD 3521
Query: 334 KSQGQDLQ-EQLAEGC---RLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR---E 386
+S +L + C R A +++++ D DE + + E+ Q S PR E
Sbjct: 3522 RSYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRE 3581
Query: 387 MQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWE 446
+ +E EV +DSL+ C T S D QP+ + EE + L
Sbjct: 3582 LLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD--------- 3632
Query: 447 DAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLASY 503
+ + D EEEE++GP PR L E E EV Q+S D YST S E+ S
Sbjct: 3633 -----VDRTKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSC 3687
Query: 504 QSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKEDQEATGPRL 544
Q Y S+F++LEE+ V ++D+G R R + +EDQ PRL
Sbjct: 3688 QPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRL 3747
Query: 545 SRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMD 600
SRELLDEK PEVLQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+GLAVDMD
Sbjct: 3748 SRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMD 3803
Score = 37.0 bits (84), Expect = 0.071
Identities = 29/86 (33%), Positives = 42/86 (48%), Gaps = 1/86 (1%)
Query: 85 QKLSPENDEDEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPC 143
Q++ D DE E Q VEED+ RE+ +E +V +DSL+ C T S
Sbjct: 3550 QRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELP 3609
Query: 144 DSIQPHKNIKITFEEDKVNSSLVVDR 169
D QP+ + + EE + +L VDR
Sbjct: 3610 DLGQPYSSAVYSLEEQYLGLALDVDR 3635
Score = 35.8 bits (81), Expect = 0.16
Identities = 39/157 (24%), Positives = 67/157 (42%), Gaps = 11/157 (7%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 2395 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2454
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 2455 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 2507
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVV 167
C T S+ DS QP+ + EE V SL V
Sbjct: 2508 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 2544
Score = 35.8 bits (81), Expect = 0.16
Identities = 39/157 (24%), Positives = 67/157 (42%), Gaps = 11/157 (7%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 2808 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 2867
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 2868 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 2920
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVV 167
C T S+ DS QP+ + EE V SL V
Sbjct: 2921 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 2957
Score = 35.8 bits (81), Expect = 0.16
Identities = 39/157 (24%), Positives = 67/157 (42%), Gaps = 11/157 (7%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP----DEPDKSQGQDLQ 70
+EI++Y+ + Q+ +L +L + ++ + + TP + PD Q
Sbjct: 3559 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSA 3618
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E Q+L L + + + E+ EED+ RE+ + E +V +DSL+
Sbjct: 3619 VYSLE----EQYLGLALDVDRTKKDQEE---EEDQGPPCPRLSRELLEVVEPEVLQDSLD 3671
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVV 167
C T S+ DS QP+ + EE V SL V
Sbjct: 3672 RCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 3708
Score = 32.3 bits (72), Expect = 1.8
Identities = 20/69 (28%), Positives = 34/69 (49%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ + +V +DSL+ C T S DS QP+++ E+ +V
Sbjct: 3737 EEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRV 3796
Query: 162 NSSLVVDRE 170
++ +D E
Sbjct: 3797 GLAVDMDGE 3805
>gi|157266285 hypothetical protein LOC728936 [Homo sapiens]
Length = 670
Score = 998 bits (2580), Expect = 0.0
Identities = 506/582 (86%), Positives = 528/582 (90%), Gaps = 1/582 (0%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
MVVSAGPLSSEKAEMNILEINEKL PQLAEKKQQFR+LKEKCF+TQ+A FLA +Q KYKY
Sbjct: 1 MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316
EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120
Query: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376
RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRL QHLVQKLSPENDNDDDEDVQVEVAE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180
Query: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436
KVQKSS+PREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH+KTKITFEEDKVDSTL
Sbjct: 181 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240
Query: 437 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 496
IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP
Sbjct: 241 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 300
Query: 497 PERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV 556
PE LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV
Sbjct: 301 PEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV 360
Query: 557 LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSC 616
LQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+GLA+DMDEIEKYQEVEEDQDPSC
Sbjct: 361 LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSC 420
Query: 617 PRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDR 676
PRLSRELL EKEPEVLQDSLDRCYSTPS YLELPDLGQPY SAVYSLEEQYLGLALDVDR
Sbjct: 421 PRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALDVDR 480
Query: 677 IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVPFM 735
IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L P F
Sbjct: 481 IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY 540
Query: 736 HWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGK 777
+ + F L +++++G+G+K ++K K+G+
Sbjct: 541 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGE 582
Score = 383 bits (984), Expect = e-106
Identities = 261/620 (42%), Positives = 337/620 (54%), Gaps = 96/620 (15%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVH+QERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 90 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRL QHLVQKLSPEND D+DEDVQVE EKV +SSAPRE+QKAEE +VPEDSLEECAI
Sbjct: 150 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 209
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILP---------- 184
TCSNSHGP DS QPHK KITFEEDKV+S+L+ SSH +DA++I+P
Sbjct: 210 TCSNSHGPYDSNQPHKKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 267
Query: 185 VPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVA 244
GP S P S + L I ++ F SL+E Q
Sbjct: 268 EKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEE-----QQV 322
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C +A ++++++ K + +++ +L+ +L +E
Sbjct: 323 C-MAVDIGRHRWDQVK-------KEDQEATGPRLSRELLDEKE----------------- 357
Query: 305 LREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN 364
E L++ D S L +P +S L++Q G +
Sbjct: 358 -PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRV-GLAI-------------- 401
Query: 365 DDDEDVQVEVAEKVQKSSSP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 421
D DE + + E+ Q S P RE+ +E EV +DSL+ C T S+ D QP+
Sbjct: 402 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYS 461
Query: 422 KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP---RNLQESEE 478
+ EE + L + + D EEEE++GP P R L E E
Sbjct: 462 SAVYSLEEQYLGLAL--------------DVDRIKKDQEEEEDQGPPCPRLSRELLEVVE 507
Query: 479 EEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG------------- 525
EV Q+S D YST S E+ S Q Y S+F++LEE+ V ++D+G
Sbjct: 508 PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 567
Query: 526 -----RHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQP 580
+ R + + ED PRL+ L++ +EPEVLQDSLDRCYST S+Y L DS Q
Sbjct: 568 RRSKKKRRRGRKEGEDDNPPCPRLNGVLMEVEEPEVLQDSLDRCYSTQSMYFELPDSFQH 627
Query: 581 YRSAFYVLEQQRIGLAVDMD 600
YRS FY E++ I A+ +D
Sbjct: 628 YRSVFYSFEEEHISFALYVD 647
Score = 224 bits (572), Expect = 2e-58
Identities = 142/327 (43%), Positives = 187/327 (57%), Gaps = 38/327 (11%)
Query: 373 EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429
+V ++ Q+++ PR E+ +E EV +DSL+ C T S DS QP+R E+
Sbjct: 335 QVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQ 394
Query: 430 DKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESW 486
+V + + E E E EE++ P PR L + +E EV Q+S
Sbjct: 395 QRVGLAID--------------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSL 440
Query: 487 DEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSR 546
D YST S E Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSR
Sbjct: 441 DRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSR 500
Query: 547 ELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY- 605
ELL+ EPEVLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 501 ELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKG 560
Query: 606 -----------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLE 648
++ ED +P CPRL+ L+ +EPEVLQDSLDRCYST S Y E
Sbjct: 561 KGKKRRGRRSKKKRRRGRKEGEDDNPPCPRLNGVLMEVEEPEVLQDSLDRCYSTQSMYFE 620
Query: 649 LPDLGQPYRSAVYSLEEQYLGLALDVD 675
LPD Q YRS YS EE+++ AL VD
Sbjct: 621 LPDSFQHYRSVFYSFEEEHISFALYVD 647
Score = 38.1 bits (87), Expect = 0.032
Identities = 48/186 (25%), Positives = 77/186 (41%), Gaps = 21/186 (11%)
Query: 5 STGRLPGQPTEEIQQYKVLVHSQERELTQLREKLREGR--DASRSLNEHLQALLTPDEPD 62
ST +P + Q Y HS E + + + R + E L+ + D
Sbjct: 295 STLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLD 354
Query: 63 KSQGQDLQEQL------AEGC----------RLAQHLV--QKLSPENDEDEDEDVQ-VEE 103
+ + + LQ+ L GC R A +++ Q++ D DE E Q VEE
Sbjct: 355 EKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEE 414
Query: 104 DEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNS 163
D+ RE+ +E +V +DSL+ C T S+ D QP+ + + EE +
Sbjct: 415 DQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGL 474
Query: 164 SLVVDR 169
+L VDR
Sbjct: 475 ALDVDR 480
>gi|29789405 hypothetical protein LOC284565 [Homo sapiens]
Length = 670
Score = 995 bits (2572), Expect = 0.0
Identities = 505/582 (86%), Positives = 527/582 (90%), Gaps = 1/582 (0%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
MVVSAGPLSSEKAEMNILEINEKL PQLAEKKQQFR+LKEKCF+TQ+A FLA +Q KYKY
Sbjct: 1 MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKY 60
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316
EECKDLIK MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDAS
Sbjct: 61 EECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDAS 120
Query: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376
RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRL QHLVQKLSPENDNDDDEDVQVEVAE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAE 180
Query: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436
KVQKSS+PREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPH+KTKITFEEDKVDSTL
Sbjct: 181 KVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL 240
Query: 437 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 496
IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP
Sbjct: 241 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIP 300
Query: 497 PERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV 556
PE LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV
Sbjct: 301 PEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV 360
Query: 557 LQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSC 616
LQDSLDRCYSTPS L LTDSCQPYRSAFYVLEQQR+GLA+DMDEIEKYQEVEEDQDPSC
Sbjct: 361 LQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSC 420
Query: 617 PRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDR 676
PRLSRELL EKEPEVLQDSLDRCYSTPS YLELPDLGQPY SAVYSLEEQYLGLAL VDR
Sbjct: 421 PRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALAVDR 480
Query: 677 IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNSLTPASPTEVPFM 735
IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L P F
Sbjct: 481 IKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFY 540
Query: 736 HWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEKKGK 777
+ + F L +++++G+G+K ++K K+G+
Sbjct: 541 ALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGE 582
Score = 384 bits (985), Expect = e-106
Identities = 261/620 (42%), Positives = 336/620 (54%), Gaps = 96/620 (15%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVH+QERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 90 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRL QHLVQKLSPEND D+DEDVQVE EKV +SSAPRE+QKAEE +VPEDSLEECAI
Sbjct: 150 EGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 209
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILP---------- 184
TCSNSHGP DS QPHK KITFEEDKV+S+L+ SSH +DA++I+P
Sbjct: 210 TCSNSHGPYDSNQPHKKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 267
Query: 185 VPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVA 244
GP S P S + L I ++ F SL+E Q
Sbjct: 268 EKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEE-----QQV 322
Query: 245 CFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ 304
C +A ++++++ K + +++ +L+ +L +E
Sbjct: 323 C-MAVDIGRHRWDQVK-------KEDQEATGPRLSRELLDEKE----------------- 357
Query: 305 LREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN 364
E L++ D S L +P +S L++Q G +
Sbjct: 358 -PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRV-GLAI-------------- 401
Query: 365 DDDEDVQVEVAEKVQKSSSP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 421
D DE + + E+ Q S P RE+ +E EV +DSL+ C T S+ D QP+
Sbjct: 402 DMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYS 461
Query: 422 KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSP---RNLQESEE 478
+ EE + L + + D EEEE++GP P R L E E
Sbjct: 462 SAVYSLEEQYLGLAL--------------AVDRIKKDQEEEEDQGPPCPRLSRELLEVVE 507
Query: 479 EEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG------------- 525
EV Q+S D YST S E+ S Q Y S+F++LEE+ V ++D+G
Sbjct: 508 PEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRG 567
Query: 526 -----RHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQP 580
+ R + + ED PRL L++ +EPEVLQDSLDRCYSTPS+Y DS Q
Sbjct: 568 RRSKKKRRRGRKEGEDDNPPCPRLYGVLMEVEEPEVLQDSLDRCYSTPSMYFEQPDSFQH 627
Query: 581 YRSAFYVLEQQRIGLAVDMD 600
YRS FY E++ I A+ +D
Sbjct: 628 YRSVFYSFEEEHISFALYVD 647
Score = 221 bits (563), Expect = 2e-57
Identities = 141/327 (43%), Positives = 185/327 (56%), Gaps = 38/327 (11%)
Query: 373 EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429
+V ++ Q+++ PR E+ +E EV +DSL+ C T S DS QP+R E+
Sbjct: 335 QVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQ 394
Query: 430 DKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESW 486
+V + + E E E EE++ P PR L + +E EV Q+S
Sbjct: 395 QRVGLAID--------------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSL 440
Query: 487 DEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSR 546
D YST S E Q YSS +SLEEQ + +A+ + R + DQ ++EDQ PRLSR
Sbjct: 441 DRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALAVDRIKKDQEEEEDQGPPCPRLSR 500
Query: 547 ELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY- 605
ELL+ EPEVLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 501 ELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKG 560
Query: 606 -----------------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLE 648
++ ED +P CPRL L+ +EPEVLQDSLDRCYSTPS Y E
Sbjct: 561 KGKKRRGRRSKKKRRRGRKEGEDDNPPCPRLYGVLMEVEEPEVLQDSLDRCYSTPSMYFE 620
Query: 649 LPDLGQPYRSAVYSLEEQYLGLALDVD 675
PD Q YRS YS EE+++ AL VD
Sbjct: 621 QPDSFQHYRSVFYSFEEEHISFALYVD 647
Score = 39.3 bits (90), Expect = 0.014
Identities = 48/186 (25%), Positives = 77/186 (41%), Gaps = 21/186 (11%)
Query: 5 STGRLPGQPTEEIQQYKVLVHSQERELTQLREKLREGR--DASRSLNEHLQALLTPDEPD 62
ST +P + Q Y HS E + + + R + E L+ + D
Sbjct: 295 STLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLD 354
Query: 63 KSQGQDLQEQL------AEGC----------RLAQHLV--QKLSPENDEDEDEDVQ-VEE 103
+ + + LQ+ L GC R A +++ Q++ D DE E Q VEE
Sbjct: 355 EKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEE 414
Query: 104 DEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNS 163
D+ RE+ +E +V +DSL+ C T S+ D QP+ + + EE +
Sbjct: 415 DQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGL 474
Query: 164 SLVVDR 169
+L VDR
Sbjct: 475 ALAVDR 480
>gi|7657017 hypothetical protein LOC25832 [Homo sapiens]
Length = 921
Score = 880 bits (2273), Expect = 0.0
Identities = 449/514 (87%), Positives = 466/514 (90%), Gaps = 6/514 (1%)
Query: 266 MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQA 325
MLRNERQFKEEKLAEQLKQAEELRQYKVLVH+QERELTQLREKLREGRDASRSLNEHLQA
Sbjct: 1 MLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQA 60
Query: 326 LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR 385
LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSS+PR
Sbjct: 61 LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPR 120
Query: 386 EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW 445
EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW
Sbjct: 121 EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW 180
Query: 446 EDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQS 505
EDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPE LASY+S
Sbjct: 181 EDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYKS 240
Query: 506 YSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCY 565
YSSTFHSLEEQQVCMAVDIGRHRWDQVKKED EATGPRLSRELLDEK PEVLQDSLDRCY
Sbjct: 241 YSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDHEATGPRLSRELLDEKGPEVLQDSLDRCY 300
Query: 566 STPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLA 625
STPS L LTDSCQPYRSAFYVLEQQR+GLAV+MDEIEKYQEVEEDQDPSCPRLSRELL
Sbjct: 301 STPSGCLELTDSCQPYRSAFYVLEQQRVGLAVNMDEIEKYQEVEEDQDPSCPRLSRELLD 360
Query: 626 EKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEE 685
EKEPEVLQDSL RCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVDRIKKDQEEEE
Sbjct: 361 EKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEE 420
Query: 686 DQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPV-VLNSLTPASPTEVPFMHWRKNMLAF 744
DQGPPCPRLSRELLEVVEPEVLQDSLD P L P F + + F
Sbjct: 421 DQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGF 480
Query: 745 LLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
L +++++G RGR+ +E +R ++EGEE
Sbjct: 481 SLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 514
Score = 647 bits (1670), Expect = 0.0
Identities = 413/829 (49%), Positives = 503/829 (60%), Gaps = 86/829 (10%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVH+QERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 21 EELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 80
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPEND D+DEDVQVE EKV +SSAPRE+QKAEE +VPEDSLEECAI
Sbjct: 81 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAI 140
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV--------- 185
TCSNSHGP DS QPH+ KITFEEDKV+S+L+ SSH +DA++I+P
Sbjct: 141 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 198
Query: 186 -PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVA 244
GP S P S + L I ++ F SL+E Q
Sbjct: 199 EKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYKSYSSTFHSLEE-----QQV 253
Query: 245 CFLAKQQNKYKYEECK--DLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQEREL 302
C +A ++++++ K D + R R+ +EK E L+ + + +S
Sbjct: 254 C-MAVDIGRHRWDQVKKEDHEATGPRLSRELLDEKGPEVLQDSLDR------CYSTPSGC 306
Query: 303 TQLREKLREGRDASRSLNEHLQAL-LTPDEPDKSQGQDLQEQLAEGC-RLAQHLVQKLSP 360
+L + + R A L + L + DE +K Q +++E C RL++ L+ + P
Sbjct: 307 LELTDSCQPYRSAFYVLEQQRVGLAVNMDEIEKYQ--EVEEDQDPSCPRLSRELLDEKEP 364
Query: 361 ENDNDD-------------------------------------DEDVQVEVAEKVQKSSS 383
E D D D + E+ +
Sbjct: 365 EVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGP 424
Query: 384 P-----REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIG 438
P RE+ + E EV +DSL+ C T S+ DS QP+ + EE V +L
Sbjct: 425 PCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDV 484
Query: 439 SSSHVEWEDAVHIIPENESD-----DEEEEEKGPVSPRNLQESEEE---EVPQESWDEGY 490
+ + ++ + E EE++ P PR +E +E EV Q+S D Y
Sbjct: 485 GEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCY 544
Query: 491 STLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLD 550
ST S E S Q Y S F+ LE+Q+V +AVD+ Q +EDQ+ + PRLS ELLD
Sbjct: 545 STPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSGELLD 604
Query: 551 EKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEE 610
EKEPEVLQ+SLDRCYSTPS L LTDSCQPYRSAFY+LEQQR+GLAVDMDEIEKYQEVEE
Sbjct: 605 EKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEE 664
Query: 611 DQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGL 670
DQDPSCPRLSRELL EKEPEVLQDSL RCYSTPSGYLELPDLGQPY SAVYSLEEQYLGL
Sbjct: 665 DQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGL 724
Query: 671 ALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLP-VVLNSLTPASP 729
ALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLD P L P
Sbjct: 725 ALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQP 784
Query: 730 TEVPFMHWRKNMLAFLLTWEKLKRRG-----RGRKEGEEDQRRKEEGEE 773
F + + F L +++++G RGR+ +E +R ++EGEE
Sbjct: 785 YGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEE 833
Score = 292 bits (747), Expect = 9e-79
Identities = 184/384 (47%), Positives = 225/384 (58%), Gaps = 46/384 (11%)
Query: 385 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVE 444
RE+ + EV +DSL+ C T S DS QP+R E+ +V +
Sbjct: 525 RELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVD------- 577
Query: 445 WEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLA 501
+ E E E EE++ P PR L + +E EV QES D YST S E
Sbjct: 578 -------MDEIEKYQEVEEDQDPSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELTD 630
Query: 502 SYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSL 561
S Q Y S F+ LE+Q+V +AVD+ Q +EDQ+ + PRLSRELLDEKEPEVLQDSL
Sbjct: 631 SCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSL 690
Query: 562 DRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSR 621
RCYSTPS YL L D QPY SA Y LE+Q +GLA+D+D I+K QE EEDQ P CPRLSR
Sbjct: 691 GRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSR 750
Query: 622 ELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD- 680
ELL EPEVLQDSLDRCYSTPS LE PD QPY S+ Y+LEE+++G +LDV I+K
Sbjct: 751 ELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKG 810
Query: 681 ------------------QEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLN 722
+E EEDQ PPCPRL+ L+EV EPEVLQDSLD+
Sbjct: 811 KGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNSMLMEVEEPEVLQDSLDICY------- 863
Query: 723 SLTPASPTEVP--FMHWRKNMLAF 744
TP+ E+P F H+R +F
Sbjct: 864 -STPSMYFELPDSFQHYRSVFYSF 886
Score = 232 bits (592), Expect = 9e-61
Identities = 201/620 (32%), Positives = 285/620 (45%), Gaps = 94/620 (15%)
Query: 94 DEDEDVQ-VEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNI 152
DE E Q VEED+ RE+ +E +V +DSL C T S D QP+ +
Sbjct: 335 DEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSA 394
Query: 153 KITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMN 212
+ EE + +L VDR ++ GP +
Sbjct: 395 VYSLEEQYLGLALDVDRIKKDQEEEE---------------------DQGP-PCPRLSRE 432
Query: 213 ILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQ 272
+LE+ E P++ + ++C+ T +C + + C+ S E
Sbjct: 433 LLEVVE---PEVLQDSL------DRCYSTPSSCL-------EQPDSCQPYGSSFYALE-- 474
Query: 273 FKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEP 332
E+ + L E ++ K R + R +EG + L L ++
Sbjct: 475 --EKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKG 532
Query: 333 DKSQGQDLQE---------QLAEGC---RLAQHLVQKLSPENDNDDDEDVQVEVAEKVQK 380
+ L +L + C R A +++++ D DE + + E+ Q
Sbjct: 533 PEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQD 592
Query: 381 SSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI 437
S PR E+ +E EV ++SL+ C T S DS QP+R E+ +V +
Sbjct: 593 PSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVD 652
Query: 438 GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLS 494
+ E E E EE++ P PR L + +E EV Q+S YST S
Sbjct: 653 --------------MDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPS 698
Query: 495 IPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554
E Q YSS +SLEEQ + +A+D+ R + DQ ++EDQ PRLSRELL+ EP
Sbjct: 699 GYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEP 758
Query: 555 EVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKY--------- 605
EVLQDSLDRCYSTPS L DSCQPY S+FY LE++ +G ++D+ EIEK
Sbjct: 759 EVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGR 818
Query: 606 ----------QEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 655
+E EEDQ+P CPRL+ L+ +EPEVLQDSLD CYSTPS Y ELPD Q
Sbjct: 819 RSKKERRRGRKEGEEDQNPPCPRLNSMLMEVEEPEVLQDSLDICYSTPSMYFELPDSFQH 878
Query: 656 YRSAVYSLEEQYLGLALDVD 675
YRS YS EE+++ AL VD
Sbjct: 879 YRSVFYSFEEEHISFALYVD 898
>gi|14149997 neuroblastoma breakpoint family, member 3 [Homo
sapiens]
Length = 633
Score = 806 bits (2082), Expect = 0.0
Identities = 420/555 (75%), Positives = 461/555 (83%), Gaps = 1/555 (0%)
Query: 159 DKVNSSLVVDRESSHD-GCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEIN 217
D S R +SH G L VPGPTSSATNVSMVVSAGP S EKAEMNILEIN
Sbjct: 18 DVETSPFGAPRAASHGVGRHQELRDPTVPGPTSSATNVSMVVSAGPWSGEKAEMNILEIN 77
Query: 218 EKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEK 277
+K PQLAE KQQFR+LK+KC VTQVA FLA +QN Y YE+CKDLIKSMLR+ER EEK
Sbjct: 78 KKSRPQLAENKQQFRNLKQKCLVTQVAYFLANRQNNYDYEDCKDLIKSMLRDERLLTEEK 137
Query: 278 LAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQG 337
LAE+L QAEELRQYKVLVHSQERELTQLREKL+EGRDASRSLN+HLQALLTPDEPD SQG
Sbjct: 138 LAEELGQAEELRQYKVLVHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPDNSQG 197
Query: 338 QDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPE 397
+DL+EQLAEGCRLAQHLVQKLSPEND+D+DEDV+VE AEKVQ+ +PRE+QKAEEKEVPE
Sbjct: 198 RDLREQLAEGCRLAQHLVQKLSPENDDDEDEDVKVEEAEKVQELYAPREVQKAEEKEVPE 257
Query: 398 DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENES 457
DSLEECAITCSNSH P +SNQP+ T+ITFEED+VDSTLI SSSH EW DAV IIPENES
Sbjct: 258 DSLEECAITCSNSHHPCESNQPYGNTRITFEEDQVDSTLIDSSSHDEWLDAVCIIPENES 317
Query: 458 DDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQ 517
D E+EEEKGPVSPRNLQESEEEE PQESWDEG TLSIPP+ ASYQS STFHS+EEQQ
Sbjct: 318 DHEQEEEKGPVSPRNLQESEEEEAPQESWDEGDWTLSIPPDMSASYQSDRSTFHSVEEQQ 377
Query: 518 VCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDS 577
V +A+DIGRH DQVKKEDQEAT PRLSRELLDEKEPEVLQDSLDR YSTP YL L D
Sbjct: 378 VGLALDIGRHWCDQVKKEDQEATSPRLSRELLDEKEPEVLQDSLDRFYSTPFEYLELPDL 437
Query: 578 CQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLD 637
CQPYRS FY L++Q +GLA+D+D ++K QE EEDQ P CPRLSREL EPE LQDSLD
Sbjct: 438 CQPYRSDFYSLQEQHLGLALDLDRMKKDQEEEEDQGPPCPRLSRELPEVVEPEDLQDSLD 497
Query: 638 RCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRE 697
R YSTP Y ELPD QPY S YSLEE+++G +LDVD I+K QE EEDQ PPCPRL+
Sbjct: 498 RWYSTPFSYPELPDSCQPYGSCFYSLEEEHVGFSLDVDEIEKYQEGEEDQKPPCPRLNEV 557
Query: 698 LLEVVEPEVLQDSLD 712
L+E EPEVLQDSLD
Sbjct: 558 LMEAEEPEVLQDSLD 572
Score = 310 bits (793), Expect = 4e-84
Identities = 215/517 (41%), Positives = 292/517 (56%), Gaps = 60/517 (11%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQERELTQLREKL+EGRDASRSLN+HLQALLTPDEPD SQG+DL+EQLA
Sbjct: 146 EELRQYKVLVHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPDNSQGRDLREQLA 205
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPEND+DEDEDV+VEE EKV E APREVQKAEE +VPEDSLEECAI
Sbjct: 206 EGCRLAQHLVQKLSPENDDDEDEDVKVEEAEKVQELYAPREVQKAEEKEVPEDSLEECAI 265
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATN 194
TCSNSH PC+S QP+ N +ITFEED+V+S+L+ SSHD DA+ I+P + ++
Sbjct: 266 TCSNSHHPCESNQPYGNTRITFEEDQVDSTLI--DSSSHDEWLDAVCIIP-----ENESD 318
Query: 195 VSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAK--QQN 252
GP+S N+ E E+ PQ S E + + ++ Q +
Sbjct: 319 HEQEEEKGPVSPR----NLQESEEEEAPQ--------ESWDEGDWTLSIPPDMSASYQSD 366
Query: 253 KYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 312
+ + ++ + + + +++ ++ ++A R + L+ +E E+ Q
Sbjct: 367 RSTFHSVEEQQVGLALDIGRHWCDQVKKEDQEATSPRLSRELLDEKEPEVLQ-------- 418
Query: 313 RDASRSLNEHLQALLTPD--EPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDV 370
R + + L PD +P +S LQE QHL L + D E+
Sbjct: 419 DSLDRFYSTPFEYLELPDLCQPYRSDFYSLQE---------QHLGLALDLDRMKKDQEE- 468
Query: 371 QVEVAEKVQKSSSP---REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITF 427
E+ Q P RE+ + E E +DSL+ T + DS QP+ +
Sbjct: 469 -----EEDQGPPCPRLSRELPEVVEPEDLQDSLDRWYSTPFSYPELPDSCQPYGSCFYSL 523
Query: 428 EEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWD 487
EE+ V +L V I + + +E+++ P L E+EE EV Q+S D
Sbjct: 524 EEEHVGFSL-----------DVDEIEKYQEGEEDQKPPCPRLNEVLMEAEEPEVLQDSLD 572
Query: 488 EGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDI 524
YST S + AS+Q Y S F+S EEQ V +A+D+
Sbjct: 573 RCYSTTSTYFQLHASFQQYRSAFYSFEEQDVSLALDV 609
Score = 38.5 bits (88), Expect = 0.025
Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 19/132 (14%)
Query: 56 LTPDEPDKSQGQDLQE-------------QLAEGCRLAQHLVQKLSPEN-----DEDEDE 97
L+ + P+ + +DLQ+ +L + C+ L E+ D DE E
Sbjct: 479 LSRELPEVVEPEDLQDSLDRWYSTPFSYPELPDSCQPYGSCFYSLEEEHVGFSLDVDEIE 538
Query: 98 DVQV-EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITF 156
Q EED+K + +AEE +V +DSL+ C T S S Q +++ +F
Sbjct: 539 KYQEGEEDQKPPCPRLNEVLMEAEEPEVLQDSLDRCYSTTSTYFQLHASFQQYRSAFYSF 598
Query: 157 EEDKVNSSLVVD 168
EE V+ +L VD
Sbjct: 599 EEQDVSLALDVD 610
>gi|239741297 PREDICTED: neuroblastoma breakpoint family, member 9
[Homo sapiens]
Length = 299
Score = 538 bits (1386), Expect = e-153
Identities = 274/287 (95%), Positives = 277/287 (96%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
MVVSAGPLSSEKAEMNILEINEKL PQLAEKKQQFRSLKEKCFVTQ+A FLAKQQNKYKY
Sbjct: 1 MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKY 60
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 316
EECKDLIKSMLRNE QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS
Sbjct: 61 EECKDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120
Query: 317 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 376
RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE
Sbjct: 121 RSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAE 180
Query: 377 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 436
KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL
Sbjct: 181 KVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTL 240
Query: 437 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQ 483
IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR S E+ P+
Sbjct: 241 IGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTSVGSSEKGGPR 287
Score = 279 bits (713), Expect = 8e-75
Identities = 146/199 (73%), Positives = 162/199 (81%), Gaps = 12/199 (6%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA
Sbjct: 90 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLAQHLVQKLSPEND D+DEDVQVE EKV +SS+PRE+QKAEE +VPEDSLEECAI
Sbjct: 150 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAI 209
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILP---------- 184
TCSNSHGP DS QPH+ KITFEEDKV+S+L+ SSH +DA++I+P
Sbjct: 210 TCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEE 267
Query: 185 VPGPTSSATNVSMVVSAGP 203
GP S T+V GP
Sbjct: 268 EKGPVSPRTSVGSSEKGGP 286
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/112 (31%), Positives = 49/112 (43%), Gaps = 17/112 (15%)
Query: 598 DMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYR 657
D DE + + E+ Q S PR E+ +E EV +DSL+ C T S D QP+R
Sbjct: 169 DDDEDVQVEVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHR 225
Query: 658 SAVYSLEEQYLGLAL--------------DVDRIKKDQEEEEDQGPPCPRLS 695
+ EE + L + + D EEEE++GP PR S
Sbjct: 226 KTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTS 277
Score = 40.0 bits (92), Expect = 0.008
Identities = 61/280 (21%), Positives = 115/280 (41%), Gaps = 49/280 (17%)
Query: 367 DEDVQVEVAEKVQKSSSPREMQKAEE------KEVPEDSLEECAITCSNSHGPYDSNQPH 420
+E ++ ++AEK Q+ S +E + K+ + EEC D +
Sbjct: 21 NEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKYEECK----------DLIKSM 70
Query: 421 RKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEE- 479
+ ++ F+E+K+ L + +++ VH + E+ +G + R+L E +
Sbjct: 71 LRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQAL 130
Query: 480 ---EVPQESWDEGYSTLSIPPERLASY--QSYSSTFHSLEEQQVCMAVDIGRHRWDQVKK 534
+ P +S + RLA + Q S + +++ V + +V +
Sbjct: 131 LTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQV----------EVAE 180
Query: 535 EDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIG 594
+ Q+++ PR E+ +E EV +DSL+ C T S G DS QP+R E+ ++
Sbjct: 181 KVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 237
Query: 595 LAV--------------DMDEIEKYQEVEEDQDPSCPRLS 620
+ + E E E EE++ P PR S
Sbjct: 238 STLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRTS 277
>gi|221136844 neuroblastoma breakpoint family, member 6 isoform 1
[Homo sapiens]
Length = 667
Score = 481 bits (1239), Expect = e-136
Identities = 293/551 (53%), Positives = 363/551 (65%), Gaps = 34/551 (6%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACF-LAKQQNKYK 255
MVVSA PLSSE+AEMNILEIN++L QLAE QQFR LKEK +TQ + LA Q KYK
Sbjct: 1 MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60
Query: 256 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 315
EE KD+I S+LR+E Q EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61 CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDV--QVE 373
SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPEND D+DED + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179
Query: 374 VAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 433
EKVQ+S +PRE+QK EEKEVP+DSLEECA+TCSNSH P +SNQPHR TKITF+E +VD
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239
Query: 434 STLIGSSSHV--EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQES---WDE 488
S L+ S H E E+A++I PEN++D EEEE K PV PRN Q E E+
Sbjct: 240 SALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRNRQSLEPGELTNLRDFLISP 299
Query: 489 GYSTLSIP--PERLASYQSYSSTFHSLEEQQVCMAVDIGRH----RWDQV------KKED 536
S ++ P ++ SY+ +F +L+EQ+VC A D+ R +WD+ K+ D
Sbjct: 300 VVSHVANPGHHDKSNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSD 359
Query: 537 ------QEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQ 590
QE PRLSR L + E+ Q+SLD C TPS+ LT S PY S Y E
Sbjct: 360 LEEVKGQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFED 419
Query: 591 QRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELP 650
+++ LA+ +D+I+K QE EDQ P CPRLS+EL KE EV +DS++ Y TPS + ++
Sbjct: 420 KQVSLAL-VDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVS 478
Query: 651 DLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDS 710
D QPY S + SLE+Q ALDV E QG LS EV ++ Q
Sbjct: 479 DCHQPYSSTLSSLEDQLACSALDV---ASPTEAACPQGTWSGDLSHHRSEV---QISQAQ 532
Query: 711 LDVIQLLPVVL 721
L+ L+P L
Sbjct: 533 LEPSTLVPSCL 543
Score = 259 bits (662), Expect = 7e-69
Identities = 179/448 (39%), Positives = 245/448 (54%), Gaps = 63/448 (14%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYK LVHSQ +ELTQLREKLREGRDASR LN+HL+ LLTPD+PDKSQGQDL+EQLA
Sbjct: 90 EELRQYKALVHSQAKELTQLREKLREGRDASRWLNKHLKTLLTPDDPDKSQGQDLREQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDV--QVEEDEKVLESSAPREVQKAEESKVPEDSLEEC 132
EG RLA+HLV KLSPENDEDEDED + EE EKV ES APREVQK EE +VP+DSLEEC
Sbjct: 150 EGHRLAEHLVHKLSPENDEDEDEDEDDKDEEVEKVQESPAPREVQKTEEKEVPQDSLEEC 209
Query: 133 AITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV-PGPTSS 191
A+TCSNSH P +S QPH++ KITF+E +V+S+LVV+ E HD ++ALNI P
Sbjct: 210 AVTCSNSHNPSNSNQPHRSTKITFKEHEVDSALVVESEHPHDEEEEALNIPPENQNDHEE 269
Query: 192 ATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQ 251
+ V S E E+ L + + P ++ K + + FLA +
Sbjct: 270 EEGKAPVPPRNRQSLEPGELTNLR-DFLISPVVSHVANPGHHDKSNSYRHREVSFLALDE 328
Query: 252 NKYKYEECKDLIKSMLRNERQFKEEKLAEQ----LKQAEELRQYKVLVHSQERELTQLRE 307
K + S R + K E L++ +L + K QE +
Sbjct: 329 QK---------VCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVK----GQE----TVAP 371
Query: 308 KLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND---- 363
+L G P DK + + ++ +GC L ++ L+P
Sbjct: 372 RLSRG----------------PLRVDKHE---IPQESLDGCCLTPSILPDLTPSYHPYWS 412
Query: 364 ---NDDDEDVQVEVAEKVQK------SSSP------REMQKAEEKEVPEDSLEECAITCS 408
+ +D+ V + + +K++K SP +E+ + +E+EVPEDS+ E +T S
Sbjct: 413 TLYSFEDKQVSLALVDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPS 472
Query: 409 NSHGPYDSNQPHRKTKITFEEDKVDSTL 436
H D +QP+ T + E+ S L
Sbjct: 473 VHHDVSDCHQPYSSTLSSLEDQLACSAL 500
Score = 58.9 bits (141), Expect = 2e-08
Identities = 69/236 (29%), Positives = 100/236 (42%), Gaps = 45/236 (19%)
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
D+ ++ QE+ PR E+ +E EV QDSL+ C T S ++S QP+RS +
Sbjct: 178 DEEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFK 234
Query: 590 QQRIGLAVDMD----------------EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQ 633
+ + A+ ++ E + E EE + P PR + L EP L
Sbjct: 235 EHEVDSALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRNRQSL----EPGELT 290
Query: 634 DSLDRCYSTPSGYLELP---DLGQPYRSAVYS---LEEQYLGLALDVDRI---------- 677
+ D S ++ P D YR S L+EQ + A DV R
Sbjct: 291 NLRDFLISPVVSHVANPGHHDKSNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETS 350
Query: 678 ------KKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA 727
+ D EE + Q PRLSR L V + E+ Q+SLD L P +L LTP+
Sbjct: 351 LGFLEKQSDLEEVKGQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPS 406
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/126 (23%), Positives = 60/126 (47%), Gaps = 19/126 (15%)
Query: 61 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND-------EDEDEDV------QVEEDEKV 107
P + ++ ++ +GC L ++ L+P ED+ V ++++D++
Sbjct: 377 PLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEE 436
Query: 108 LESSAP------REVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
+E +P +E+ + +E +VPEDS+ E +T S H D QP+ + + E+
Sbjct: 437 IEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLA 496
Query: 162 NSSLVV 167
S+L V
Sbjct: 497 CSALDV 502
>gi|221218991 neuroblastoma breakpoint family, member 4 [Homo
sapiens]
Length = 638
Score = 477 bits (1227), Expect = e-134
Identities = 289/546 (52%), Positives = 355/546 (65%), Gaps = 53/546 (9%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACF-LAKQQNKYK 255
MVVSA PLSSE+AEMNILEIN++L QLAE QQFR LKEK +TQ + LA Q KYK
Sbjct: 1 MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60
Query: 256 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 315
EE KD+I S+LR+E Q EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61 CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDV--QVE 373
SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPEND D+DED + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179
Query: 374 VAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 433
EKVQ+S +PRE+QK EEKEVP+DSLEECA+TCSNSH P +SNQPHR TKITF+E +VD
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239
Query: 434 STLIGSSSHV--EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYS 491
S L+ S H E E+A++I PEN++D EEEE K PV PR+ +S
Sbjct: 240 SALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSN-------------- 285
Query: 492 TLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRH----RWDQV------KKED----- 536
SY+ +F +L+EQ+VC A D+ R +WD+ K+ D
Sbjct: 286 ----------SYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVK 335
Query: 537 -QEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGL 595
QE PRLSR L + E+ Q+SLD C TPS+ LT S PY S Y E +++ L
Sbjct: 336 GQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSL 395
Query: 596 AVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 655
A+ +D+I+K QE EDQ P CPRLS+EL KE EV +DS++ Y TPS + ++ D QP
Sbjct: 396 AL-VDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQP 454
Query: 656 YRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQ 715
Y S + SLE+Q ALDV E QG LS EV +V Q L+
Sbjct: 455 YSSTLSSLEDQLACSALDV---ASPTEAACPQGTWSGDLSHHQSEV---QVSQAQLEPST 508
Query: 716 LLPVVL 721
L+P L
Sbjct: 509 LVPSCL 514
Score = 257 bits (656), Expect = 3e-68
Identities = 175/427 (40%), Positives = 239/427 (55%), Gaps = 50/427 (11%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYK LVHSQ +ELTQLREKLREGRDASR LN+HL+ LLTPD+PDKSQGQDL+EQLA
Sbjct: 90 EELRQYKALVHSQAKELTQLREKLREGRDASRWLNKHLKTLLTPDDPDKSQGQDLREQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDV--QVEEDEKVLESSAPREVQKAEESKVPEDSLEEC 132
EG RLA+HLV KLSPENDEDEDED + EE EKV ES APREVQK EE +VP+DSLEEC
Sbjct: 150 EGHRLAEHLVHKLSPENDEDEDEDEDDKDEEVEKVQESPAPREVQKTEEKEVPQDSLEEC 209
Query: 133 AITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSA 192
A+TCSNSH P +S QPH++ KITF+E +V+S+LVV+ E HD ++ALNI P
Sbjct: 210 AVTCSNSHNPSNSNQPHRSTKITFKEHEVDSALVVESEHPHDEEEEALNIPP-------- 261
Query: 193 TNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQN 252
+ E+ + + + ++ F +L E+ + A +A+ +
Sbjct: 262 ------ENQNDHEEEEGKAPVPPRHHDKSNSYRHREVSFLALDEQKVCS--AQDVARDYS 313
Query: 253 KYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 312
K++E S+ E+Q E++ Q A L + + V E + ++ +G
Sbjct: 314 NPKWDE-----TSLGFLEKQSDLEEVKGQETVAPRLSRGPLRVDKHE-----IPQESLDG 363
Query: 313 RDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQV 372
+ S+ L P +D Q LA LV K+ + + +D
Sbjct: 364 CCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLA--------LVDKIKKDQEEIED----- 410
Query: 373 EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429
Q PR E+ + +E+EVPEDS+ E +T S H D +QP+ T + E+
Sbjct: 411 ------QSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLED 464
Query: 430 DKVDSTL 436
S L
Sbjct: 465 QLACSAL 471
Score = 55.8 bits (133), Expect = 1e-07
Identities = 60/214 (28%), Positives = 94/214 (43%), Gaps = 30/214 (14%)
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
D+ ++ QE+ PR E+ +E EV QDSL+ C T S ++S QP+RS +
Sbjct: 178 DEEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFK 234
Query: 590 QQRIGLAVDMD----------------EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQ 633
+ + A+ ++ E + E EE + P PR + + + EV
Sbjct: 235 EHEVDSALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSNSYRHREVSF 294
Query: 634 DSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPR 693
+LD D+ + Y + + +E LG + D EE + Q PR
Sbjct: 295 LALDE-----QKVCSAQDVARDYSNPKW--DETSLGFL----EKQSDLEEVKGQETVAPR 343
Query: 694 LSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA 727
LSR L V + E+ Q+SLD L P +L LTP+
Sbjct: 344 LSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPS 377
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/126 (23%), Positives = 60/126 (47%), Gaps = 19/126 (15%)
Query: 61 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND-------EDEDEDV------QVEEDEKV 107
P + ++ ++ +GC L ++ L+P ED+ V ++++D++
Sbjct: 348 PLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEE 407
Query: 108 LESSAP------REVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
+E +P +E+ + +E +VPEDS+ E +T S H D QP+ + + E+
Sbjct: 408 IEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLA 467
Query: 162 NSSLVV 167
S+L V
Sbjct: 468 CSALDV 473
>gi|221136848 neuroblastoma breakpoint family, member 6 isoform 2
[Homo sapiens]
Length = 638
Score = 476 bits (1226), Expect = e-134
Identities = 288/546 (52%), Positives = 355/546 (65%), Gaps = 53/546 (9%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACF-LAKQQNKYK 255
MVVSA PLSSE+AEMNILEIN++L QLAE QQFR LKEK +TQ + LA Q KYK
Sbjct: 1 MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK 60
Query: 256 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 315
EE KD+I S+LR+E Q EKLAE+L+QAEELRQYK LVHSQ +ELTQLREKLREGRDA
Sbjct: 61 CEEYKDIIDSVLRDELQ-SMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDA 119
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDV--QVE 373
SR LN+HL+ LLTPD+PDKSQGQDL+EQLAEG RLA+HLV KLSPEND D+DED + E
Sbjct: 120 SRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDE 179
Query: 374 VAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 433
EKVQ+S +PRE+QK EEKEVP+DSLEECA+TCSNSH P +SNQPHR TKITF+E +VD
Sbjct: 180 EVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVD 239
Query: 434 STLIGSSSHV--EWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYS 491
S L+ S H E E+A++I PEN++D EEEE K PV PR+ +S
Sbjct: 240 SALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSN-------------- 285
Query: 492 TLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRH----RWDQV------KKED----- 536
SY+ +F +L+EQ+VC A D+ R +WD+ K+ D
Sbjct: 286 ----------SYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVK 335
Query: 537 -QEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGL 595
QE PRLSR L + E+ Q+SLD C TPS+ LT S PY S Y E +++ L
Sbjct: 336 GQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSL 395
Query: 596 AVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQP 655
A+ +D+I+K QE EDQ P CPRLS+EL KE EV +DS++ Y TPS + ++ D QP
Sbjct: 396 AL-VDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQP 454
Query: 656 YRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQ 715
Y S + SLE+Q ALDV E QG LS EV ++ Q L+
Sbjct: 455 YSSTLSSLEDQLACSALDV---ASPTEAACPQGTWSGDLSHHRSEV---QISQAQLEPST 508
Query: 716 LLPVVL 721
L+P L
Sbjct: 509 LVPSCL 514
Score = 257 bits (656), Expect = 3e-68
Identities = 175/427 (40%), Positives = 239/427 (55%), Gaps = 50/427 (11%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYK LVHSQ +ELTQLREKLREGRDASR LN+HL+ LLTPD+PDKSQGQDL+EQLA
Sbjct: 90 EELRQYKALVHSQAKELTQLREKLREGRDASRWLNKHLKTLLTPDDPDKSQGQDLREQLA 149
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDV--QVEEDEKVLESSAPREVQKAEESKVPEDSLEEC 132
EG RLA+HLV KLSPENDEDEDED + EE EKV ES APREVQK EE +VP+DSLEEC
Sbjct: 150 EGHRLAEHLVHKLSPENDEDEDEDEDDKDEEVEKVQESPAPREVQKTEEKEVPQDSLEEC 209
Query: 133 AITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSA 192
A+TCSNSH P +S QPH++ KITF+E +V+S+LVV+ E HD ++ALNI P
Sbjct: 210 AVTCSNSHNPSNSNQPHRSTKITFKEHEVDSALVVESEHPHDEEEEALNIPP-------- 261
Query: 193 TNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQN 252
+ E+ + + + ++ F +L E+ + A +A+ +
Sbjct: 262 ------ENQNDHEEEEGKAPVPPRHHDKSNSYRHREVSFLALDEQKVCS--AQDVARDYS 313
Query: 253 KYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 312
K++E S+ E+Q E++ Q A L + + V E + ++ +G
Sbjct: 314 NPKWDE-----TSLGFLEKQSDLEEVKGQETVAPRLSRGPLRVDKHE-----IPQESLDG 363
Query: 313 RDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQV 372
+ S+ L P +D Q LA LV K+ + + +D
Sbjct: 364 CCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLA--------LVDKIKKDQEEIED----- 410
Query: 373 EVAEKVQKSSSPR---EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEE 429
Q PR E+ + +E+EVPEDS+ E +T S H D +QP+ T + E+
Sbjct: 411 ------QSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLED 464
Query: 430 DKVDSTL 436
S L
Sbjct: 465 QLACSAL 471
Score = 55.8 bits (133), Expect = 1e-07
Identities = 60/214 (28%), Positives = 94/214 (43%), Gaps = 30/214 (14%)
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
D+ ++ QE+ PR E+ +E EV QDSL+ C T S ++S QP+RS +
Sbjct: 178 DEEVEKVQESPAPR---EVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFK 234
Query: 590 QQRIGLAVDMD----------------EIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQ 633
+ + A+ ++ E + E EE + P PR + + + EV
Sbjct: 235 EHEVDSALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSNSYRHREVSF 294
Query: 634 DSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPR 693
+LD D+ + Y + + +E LG + D EE + Q PR
Sbjct: 295 LALDE-----QKVCSAQDVARDYSNPKW--DETSLGFL----EKQSDLEEVKGQETVAPR 343
Query: 694 LSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA 727
LSR L V + E+ Q+SLD L P +L LTP+
Sbjct: 344 LSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPS 377
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/126 (23%), Positives = 60/126 (47%), Gaps = 19/126 (15%)
Query: 61 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND-------EDEDEDV------QVEEDEKV 107
P + ++ ++ +GC L ++ L+P ED+ V ++++D++
Sbjct: 348 PLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEE 407
Query: 108 LESSAP------REVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
+E +P +E+ + +E +VPEDS+ E +T S H D QP+ + + E+
Sbjct: 408 IEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLA 467
Query: 162 NSSLVV 167
S+L V
Sbjct: 468 CSALDV 473
>gi|114158664 hypothetical protein LOC343505 [Homo sapiens]
Length = 421
Score = 467 bits (1202), Expect = e-131
Identities = 255/385 (66%), Positives = 292/385 (75%), Gaps = 11/385 (2%)
Query: 184 PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQV 243
PVPG TSSATNV+MVVSAGP SSEKAEMNILEINEKL PQLAE KQQFR++K+K VTQ+
Sbjct: 8 PVPGSTSSATNVTMVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNMKQKFLVTQM 67
Query: 244 ACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 303
A FLA QQNKYKYEECKDLIKSMLR E QFKEEKLAEQLKQAEELRQYKVLVHSQEREL
Sbjct: 68 AGFLANQQNKYKYEECKDLIKSMLREELQFKEEKLAEQLKQAEELRQYKVLVHSQERELI 127
Query: 304 QLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 363
QLREKLREGRDAS SLN+HLQALLTPD+ D SQGQD +EQLAEGCRLA+HLV KLSPEND
Sbjct: 128 QLREKLREGRDASHSLNQHLQALLTPDKHDNSQGQDFREQLAEGCRLARHLVHKLSPEND 187
Query: 364 NDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKT 423
D+DE+ + + +KVQ+S +PRE QKAEEKEVPEDSLEECAIT SNSHGP DSN PH+
Sbjct: 188 TDEDENDKTKELDKVQESPAPREEQKAEEKEVPEDSLEECAITYSNSHGPSDSNPPHKNI 247
Query: 424 KITFEEDKVDSTLI--GSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR--------NL 473
KIT EEDKV+S L+ SS EW+DA++I+ EN++DDEEEE K PV P+ L
Sbjct: 248 KITSEEDKVNSILVVDSESSQDEWQDALNILLENQNDDEEEEGKAPVPPQVTLWICGLKL 307
Query: 474 QESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVK 533
QESEE+EV Q+S +E +T + SYQ TF +L EQ+VC A D+ K
Sbjct: 308 QESEEKEVLQDSPEERVTTSCSDHDVSQSYQPCEGTFLALVEQKVCSAQDVASEH-SNSK 366
Query: 534 KEDQEATGPRLSRELLDEKEPEVLQ 558
E+ P DEK+ + Q
Sbjct: 367 GEETPLGFPDTKYCWKDEKDERMSQ 391
Score = 259 bits (663), Expect = 5e-69
Identities = 134/169 (79%), Positives = 145/169 (85%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++QYKVLVHSQEREL QLREKLREGRDAS SLN+HLQALLTPD+ D SQGQD +EQLA
Sbjct: 110 EELRQYKVLVHSQERELIQLREKLREGRDASHSLNQHLQALLTPDKHDNSQGQDFREQLA 169
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAI 134
EGCRLA+HLV KLSPEND DEDE+ + +E +KV ES APRE QKAEE +VPEDSLEECAI
Sbjct: 170 EGCRLARHLVHKLSPENDTDEDENDKTKELDKVQESPAPREEQKAEEKEVPEDSLEECAI 229
Query: 135 TCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNIL 183
T SNSHGP DS PHKNIKIT EEDKVNS LVVD ESS D QDALNIL
Sbjct: 230 TYSNSHGPSDSNPPHKNIKITSEEDKVNSILVVDSESSQDEWQDALNIL 278
Score = 47.0 bits (110), Expect = 7e-05
Identities = 45/158 (28%), Positives = 69/158 (43%), Gaps = 27/158 (17%)
Query: 574 LTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQ 633
L + C+ R + L + D DE +K +E+++ Q+ P RE +E EV +
Sbjct: 168 LAEGCRLARHLVHKLSPEN---DTDEDENDKTKELDKVQESPAP---REEQKAEEKEVPE 221
Query: 634 DSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD----------------RI 677
DSL+ C T S D P+++ + EE + L VD
Sbjct: 222 DSLEECAITYSNSHGPSDSNPPHKNIKITSEEDKVNSILVVDSESSQDEWQDALNILLEN 281
Query: 678 KKDQEEEEDQGPPCPRLS-----RELLEVVEPEVLQDS 710
+ D EEEE + P P+++ +L E E EVLQDS
Sbjct: 282 QNDDEEEEGKAPVPPQVTLWICGLKLQESEEKEVLQDS 319
Score = 45.4 bits (106), Expect = 2e-04
Identities = 48/177 (27%), Positives = 77/177 (43%), Gaps = 22/177 (12%)
Query: 530 DQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLE 589
D+ K+ D+ P RE +E EV +DSL+ C T S G +DS P+++ E
Sbjct: 194 DKTKELDKVQESPA-PREEQKAEEKEVPEDSLEECAITYSNSHGPSDSNPPHKNIKITSE 252
Query: 590 QQRIG--LAVDMD--------------EIEKYQEVEEDQDPSCPRLS-----RELLAEKE 628
+ ++ L VD + E + E EE + P P+++ +L +E
Sbjct: 253 EDKVNSILVVDSESSQDEWQDALNILLENQNDDEEEEGKAPVPPQVTLWICGLKLQESEE 312
Query: 629 PEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEE 685
EVLQDS + +T ++ QP +L EQ + A DV + + EE
Sbjct: 313 KEVLQDSPEERVTTSCSDHDVSQSYQPCEGTFLALVEQKVCSAQDVASEHSNSKGEE 369
>gi|239758011 PREDICTED: hypothetical protein LOC728841, partial
[Homo sapiens]
Length = 166
Score = 159 bits (401), Expect = 1e-38
Identities = 81/119 (68%), Positives = 90/119 (75%), Gaps = 19/119 (15%)
Query: 576 DSCQPYRSAFYVLEQQRIGLAVDMDEIEKY-------------------QEVEEDQDPSC 616
DSCQPY S+FY LE++ +G ++D+ EIEK +E EEDQ+P C
Sbjct: 5 DSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPC 64
Query: 617 PRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 675
PRLSRELL EKEPEVLQDSLDRCYSTPSGYLELPDLGQPY SAVYSLEEQYLGLALDVD
Sbjct: 65 PRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVD 123
Score = 110 bits (275), Expect = 5e-24
Identities = 63/122 (51%), Positives = 77/122 (63%), Gaps = 19/122 (15%)
Query: 498 ERLASYQSYSSTFHSLEEQQVCMAVDIG-------------------RHRWDQVKKEDQE 538
E+ S Q Y S+F++LEE+ V ++D+G R R + +EDQ
Sbjct: 2 EQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQN 61
Query: 539 ATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVD 598
PRLSRELLDEKEPEVLQDSLDRCYSTPS YL L D QPY SA Y LE+Q +GLA+D
Sbjct: 62 PPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALD 121
Query: 599 MD 600
+D
Sbjct: 122 VD 123
Score = 79.7 bits (195), Expect = 1e-14
Identities = 44/85 (51%), Positives = 53/85 (62%), Gaps = 19/85 (22%)
Query: 647 LELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKD-------------------QEEEEDQ 687
LE PD QPY S+ Y+LEE+++G +LDV I+K +E EEDQ
Sbjct: 1 LEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQ 60
Query: 688 GPPCPRLSRELLEVVEPEVLQDSLD 712
PPCPRLSRELL+ EPEVLQDSLD
Sbjct: 61 NPPCPRLSRELLDEKEPEVLQDSLD 85
Score = 43.5 bits (101), Expect = 8e-04
Identities = 29/68 (42%), Positives = 39/68 (57%), Gaps = 3/68 (4%)
Query: 460 EEEEEKGPVSPR---NLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQ 516
E EE++ P PR L + +E EV Q+S D YST S E Q YSS +SLEEQ
Sbjct: 55 EGEEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQ 114
Query: 517 QVCMAVDI 524
+ +A+D+
Sbjct: 115 YLGLALDV 122
Score = 31.6 bits (70), Expect = 3.0
Identities = 22/69 (31%), Positives = 33/69 (47%)
Query: 102 EEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKV 161
EED+ RE+ +E +V +DSL+ C T S D QP+ + + EE +
Sbjct: 57 EEDQNPPCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYL 116
Query: 162 NSSLVVDRE 170
+L VD E
Sbjct: 117 GLALDVDSE 125
>gi|239747446 PREDICTED: similar to Neuroblastoma breakpoint family
member 6-like protein [Homo sapiens]
Length = 298
Score = 113 bits (282), Expect = 8e-25
Identities = 73/190 (38%), Positives = 106/190 (55%), Gaps = 9/190 (4%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACF-LAKQQNKYK 255
M VSA +AEM+ILE N+ L +L + KQ F+ L EK ++ + L KYK
Sbjct: 1 MAVSATTCFGPRAEMSILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60
Query: 256 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 315
EECKDLI+S+L E QF+E +LAE + A LR + L+ +Q ELT LR+K++EGR
Sbjct: 61 CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKIQEGRGV 120
Query: 316 SRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN-DDD 367
+H+ + LL + Q Q EQ+ +G +L + LV+KL+ EN N +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180
Query: 368 EDVQVEVAEK 377
ED Q +A +
Sbjct: 181 EDRQKPLAPR 190
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 8/86 (9%)
Query: 23 LVHSQERELTQLREKLREGRDASRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAE 75
L+ +Q ELT LR+K++EGR +H+ + LL + Q Q EQ+ +
Sbjct: 99 LIQAQAEELTHLRQKIQEGRGVCYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQ 158
Query: 76 GCRLAQHLVQKLSPEN-DEDEDEDVQ 100
G +L + LV+KL+ EN + ++ED Q
Sbjct: 159 GSQLTEILVRKLATENHNGKKNEDRQ 184
>gi|239741304 PREDICTED: similar to Neuroblastoma breakpoint family
member 6-like protein [Homo sapiens]
Length = 298
Score = 110 bits (275), Expect = 5e-24
Identities = 72/190 (37%), Positives = 105/190 (55%), Gaps = 9/190 (4%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACF-LAKQQNKYK 255
M VSA +AE++ILE N+ L +L + KQ F+ L EK ++ + L KYK
Sbjct: 1 MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60
Query: 256 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 315
EECKDLI+S+L E QF+E +LAE + A LR + L+ +Q ELT LR+K +EGR
Sbjct: 61 CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120
Query: 316 SRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN-DDD 367
+H+ + LL + Q Q EQ+ +G +L + LV+KL+ EN N +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180
Query: 368 EDVQVEVAEK 377
ED Q +A +
Sbjct: 181 EDRQKPLAPR 190
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 8/86 (9%)
Query: 23 LVHSQERELTQLREKLREGRDASRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAE 75
L+ +Q ELT LR+K +EGR +H+ + LL + Q Q EQ+ +
Sbjct: 99 LIQAQAEELTHLRQKTQEGRGVCYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQ 158
Query: 76 GCRLAQHLVQKLSPEN-DEDEDEDVQ 100
G +L + LV+KL+ EN + ++ED Q
Sbjct: 159 GSQLTEILVRKLATENHNGKKNEDRQ 184
>gi|239741281 PREDICTED: Neuroblastoma breakpoint family member
6-like protein [Homo sapiens]
Length = 322
Score = 110 bits (275), Expect = 5e-24
Identities = 72/190 (37%), Positives = 105/190 (55%), Gaps = 9/190 (4%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACF-LAKQQNKYK 255
M VSA +AE++ILE N+ L +L + KQ F+ L EK ++ + L KYK
Sbjct: 1 MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60
Query: 256 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 315
EECKDLI+S+L E QF+E +LAE + A LR + L+ +Q ELT LR+K +EGR
Sbjct: 61 CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120
Query: 316 SRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN-DDD 367
+H+ + LL + Q Q EQ+ +G +L + LV+KL+ EN N +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQGSQLTEILVRKLATENHNGKKN 180
Query: 368 EDVQVEVAEK 377
ED Q +A +
Sbjct: 181 EDRQKPLAPR 190
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 8/86 (9%)
Query: 23 LVHSQERELTQLREKLREGRDASRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAE 75
L+ +Q ELT LR+K +EGR +H+ + LL + Q Q EQ+ +
Sbjct: 99 LIQAQAEELTHLRQKTQEGRGVCYLFTQHVKNTVKSFEGLLRNTDIAYYQRQRFCEQMVQ 158
Query: 76 GCRLAQHLVQKLSPEN-DEDEDEDVQ 100
G +L + LV+KL+ EN + ++ED Q
Sbjct: 159 GSQLTEILVRKLATENHNGKKNEDRQ 184
>gi|239752894 PREDICTED: Neuroblastoma breakpoint family member
6-like protein [Homo sapiens]
Length = 298
Score = 107 bits (268), Expect = 3e-23
Identities = 72/190 (37%), Positives = 103/190 (54%), Gaps = 9/190 (4%)
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACF-LAKQQNKYK 255
M VSA +AE++ILE N+ L +L + KQ F+ L EK ++ + L KYK
Sbjct: 1 MAVSATTCFGPRAEISILETNQYLRSELEKCKQNFQDLTEKFLTSKATAYSLTNHLQKYK 60
Query: 256 YEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDA 315
EECKDLI+S+L E QF+E +LAE + A LR + L+ +Q ELT LR+K +EGR
Sbjct: 61 CEECKDLIESVLEEEVQFQERELAELPRSAARLRIHDPLIQAQAEELTHLRQKTQEGRGV 120
Query: 316 SRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN-DDD 367
+H+ + LL Q Q EQ+ +G +L + LV+KL EN N +
Sbjct: 121 CYLFTQHVKNTVKSFEGLLRNTGIAYYQRQRFCEQMVQGSQLTEILVRKLVTENHNGKKN 180
Query: 368 EDVQVEVAEK 377
ED Q +A +
Sbjct: 181 EDRQKPLAPR 190
Score = 40.4 bits (93), Expect = 0.006
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 23 LVHSQERELTQLREKLREGRDASRSLNEHL-------QALLTPDEPDKSQGQDLQEQLAE 75
L+ +Q ELT LR+K +EGR +H+ + LL Q Q EQ+ +
Sbjct: 99 LIQAQAEELTHLRQKTQEGRGVCYLFTQHVKNTVKSFEGLLRNTGIAYYQRQRFCEQMVQ 158
Query: 76 GCRLAQHLVQKLSPEN-DEDEDEDVQ 100
G +L + LV+KL EN + ++ED Q
Sbjct: 159 GSQLTEILVRKLVTENHNGKKNEDRQ 184
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo
sapiens]
Length = 2346
Score = 79.3 bits (194), Expect = 1e-14
Identities = 61/204 (29%), Positives = 106/204 (51%), Gaps = 18/204 (8%)
Query: 257 EECKDLIKSMLRNERQFK----EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREG 312
++ + LI+ + + E Q EEKLAE+L+ A +Y L+ Q REL+ LR+K+REG
Sbjct: 1436 KDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREG 1495
Query: 313 RDASRSLNEH-------LQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDND 365
R + H + LL ++ D GQ +EQLA+G +L + L KLS ++
Sbjct: 1496 RGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKS 1555
Query: 366 DDEDVQVE-VAEKVQKSSSPREMQKAEEK-EVPEDSLEECAITCSNSHGPYDSNQPHRKT 423
+ + +E +A ++ RE+Q+ E+ EV + L+ ++T S+SH DS++ T
Sbjct: 1556 EKDQAGLEPLALRLS-----RELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSST 1610
Query: 424 KITFEEDKVDSTLIGSSSHVEWED 447
+E + S + S + +E+
Sbjct: 1611 SFLSDELEACSDMDIVSEYTHYEE 1634
Score = 67.4 bits (163), Expect = 5e-11
Identities = 58/207 (28%), Positives = 99/207 (47%), Gaps = 20/207 (9%)
Query: 19 QYKVLVHSQERELTQLREKLREGRDASRSLNEH-------LQALLTPDEPDKSQGQDLQE 71
+Y L+ Q REL+ LR+K+REGR + H + LL ++ D GQ +E
Sbjct: 1473 KYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFRE 1532
Query: 72 QLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEE-SKVPEDSLE 130
QLA+G +L + L KLS ++ + E + +E L RE+Q+ E+ +V + L+
Sbjct: 1533 QLAQGSQLTERLTSKLSTKDHKSEKDQAGLEP----LALRLSRELQEKEKVIEVLQAKLD 1588
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTS 190
++T S+SH DS + + +E + S + + E +H + P +
Sbjct: 1589 ARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTH---YEEKKASPSHSDSI 1645
Query: 191 SATNVSMVVSAGPLSSE-----KAEMN 212
++ S V+S+ P S+ KAE N
Sbjct: 1646 HHSSHSAVLSSKPSSTSASQGAKAESN 1672
Score = 47.8 bits (112), Expect = 4e-05
Identities = 138/673 (20%), Positives = 261/673 (38%), Gaps = 131/673 (19%)
Query: 28 ERELTQLREKLREGRDASRSLNEHLQALLTP-DEPDKSQGQDLQEQLAEGC----RLAQH 82
+ E+ LR + + + R E L+ L +E S ++ + C L +
Sbjct: 1003 QEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQ 1062
Query: 83 LVQKLSP--ENDEDEDE-DVQVEE---DEKVLESSAPREVQKAEESKVPEDSLEECA--- 133
+ + +S E +ED+++ +V VE E + ESS E +K + ++
Sbjct: 1063 MGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQ 1122
Query: 134 ITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSAT 193
+ S+ G + P + +T +++N+ LV + + + P P P S
Sbjct: 1123 LVLSSKEGN-SKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDL 1181
Query: 194 NVSMVVSAGPLSSE--------KAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC 245
+ V A L ++ ++ ++ + L QL++ KQ+++ L+EK +++
Sbjct: 1182 GATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATV 1241
Query: 246 F-----------------LAKQQNKYKYEECKDL-IKSMLRNERQFKEEKLAE------- 280
F L KQ +K + +DL ++ R+E + + E+
Sbjct: 1242 FAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHN 1301
Query: 281 QLKQ--------AEELRQYKVLVHSQERE--------------------LTQLREKLREG 312
LK+ +E+ R+ L S ER+ + LR+ +++
Sbjct: 1302 SLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDL 1361
Query: 313 RDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRL-AQHLVQKLSPENDNDDDEDVQ 371
+ ++ N+ +Q L + S D L +L A ++ SP + D+DE
Sbjct: 1362 KAQLQNANKVIQNLKSRVR-SLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWL 1420
Query: 372 VE----------VAEKVQKSSSPREMQKAEEKEVPEDSLEECA---ITCSNSHGPYDSNQ 418
+ A+K +S R Q E ++P++ LEE + ++ G YDS
Sbjct: 1421 SDGTGAFYSPGLQAKKDLESLIQRVSQL--EAQLPKNGLEEKLAEELRSASWPGKYDSLI 1478
Query: 419 PHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEE 478
+ ++++ K+ E ++I + D + E L+ ++
Sbjct: 1479 QDQARELSYLRQKIR----------EGRGICYLITRHAKDTVKSFED------LLRSNDI 1522
Query: 479 EEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQE 538
+ +S+ E + S ERL S S+ H E+ Q + E
Sbjct: 1523 DYYLGQSFREQLAQGSQLTERLTS--KLSTKDHKSEKDQAGL-----------------E 1563
Query: 539 ATGPRLSRELLD-EKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAV 597
RLSREL + EK EVLQ LD TPS L+DS + S ++ ++ +
Sbjct: 1564 PLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDE--LEACS 1621
Query: 598 DMDEIEKYQEVEE 610
DMD + +Y EE
Sbjct: 1622 DMDIVSEYTHYEE 1634
Score = 38.9 bits (89), Expect = 0.019
Identities = 86/425 (20%), Positives = 171/425 (40%), Gaps = 45/425 (10%)
Query: 9 LPGQPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALL-TPDEPDKSQGQ 67
+PG + QY + +++ + +L + L L+ Q LL +EP + Q
Sbjct: 154 VPGDQVKP-DQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQ 212
Query: 68 DLQEQLAEGCRLAQHLV----QKLSPENDEDEDEDVQ-VEEDEKVLESSAPR---EVQKA 119
+ E+L + +L H Q +S + + E +Q E K+L+ E++ A
Sbjct: 213 PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCA 272
Query: 120 EESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDA 179
+ES +D T N S + E + N ++ RE H
Sbjct: 273 QESSQKQDG------TIQNLKETLKSRERETEELYQVIEGQ-NDTMAKLREMLHQSQLGQ 325
Query: 180 LNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCF 239
L+ G + + V+++ L + E+ +KL + +K++Q K+
Sbjct: 326 LH--SSEGTSPAQQQVALLDLQSALFCSQLEI------QKLQRVVRQKERQLADAKQCVQ 377
Query: 240 VTQVACFLAKQQNKYKYEECKDLIKSM------LRNE----RQFKEEKLAEQLKQAEELR 289
+ A ++QQ + ++ ++L K++ L+N+ R ++ EK E Q + ++
Sbjct: 378 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ 437
Query: 290 QYKVLVHSQERELTQLREKL--REGRDASRSLNEHLQALLTPDEPDKSQGQD--LQEQLA 345
+ +E+ L + RE L R+ D + NE L L DK+ + + E+ +
Sbjct: 438 HLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFS 497
Query: 346 EGCRLAQHLVQ-KLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECA 404
+ L Q +L+ + D E ++ ++ S + +A+ EV E+ +
Sbjct: 498 ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEV-----EQLS 552
Query: 405 ITCSN 409
TC N
Sbjct: 553 TTCQN 557
Score = 35.4 bits (80), Expect = 0.21
Identities = 41/187 (21%), Positives = 79/187 (42%), Gaps = 34/187 (18%)
Query: 210 EMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRN 269
E NI +N L + K+Q + +E L + N K E +++ LR
Sbjct: 433 EQNIQHLNHSL----SHKEQLLQEFRE---------LLQYRDNSDKTLEANEMLLEKLRQ 479
Query: 270 ERQFK--------EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNE 321
K +EK + ++ +ELRQ ++ V ++ +L +LR+ L +S+
Sbjct: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMES 539
Query: 322 HLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKS 381
L+A +G ++ EQL+ C+ Q L +++ + E Q + +++Q S
Sbjct: 540 LLRA----------KGLEV-EQLSTTCQNLQWLKEEMETKFSRWQKE--QESIIQQLQTS 586
Query: 382 SSPREMQ 388
R +
Sbjct: 587 LHDRNKE 593
Score = 31.2 bits (69), Expect = 3.9
Identities = 26/80 (32%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 286 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 345
E+ R+ + + RE +Q E LRE +SRS HLQ L E K + Q L E L
Sbjct: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRS---HLQELEKELEHQKVERQQLLEDLR 1965
Query: 346 EGCRLAQHLVQKLSPENDND 365
E + H ++ +ND
Sbjct: 1966 EKQQEVLHFREERLSLQEND 1985
Score = 30.4 bits (67), Expect = 6.7
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 14/116 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
E+ ++ + + RE +Q E LRE +SRS HLQ L E K + Q L E L
Sbjct: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRS---HLQELEKELEHQKVERQQLLEDLR 1965
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
E + H +E + ++E++ L+ Q+ EE + +SL+
Sbjct: 1966 EKQQEVLHF-----------REERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQ 2010
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 63.5 bits (153), Expect = 7e-10
Identities = 179/851 (21%), Positives = 332/851 (39%), Gaps = 137/851 (16%)
Query: 27 QERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQK 86
+E E+ LR +++E + R + + LL+ D ++Q DLQ++ + + +++
Sbjct: 1433 REEEVETLRGQIQE-LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH 1491
Query: 87 LSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSI 146
L P ++ ++ + V+ E++ E RE Q+ V E L E +
Sbjct: 1492 L-PMAVQEREQKLTVQR-EQIRELEKDRETQR----NVLEHQLLELEKKDQMIESQRGQV 1545
Query: 147 QPHKNIKITFEEDKVNSSLVVDRESSHDG--CQDALNILPVPGPTSSAT------NVSMV 198
Q K +T E L ++ E +H CQ L I + G + + +
Sbjct: 1546 QDLKKQLVTLE------CLALELEENHHKMECQQKL-IKELEGQRETQRVALTHLTLDLE 1598
Query: 199 VSAGPLSSEKAEMNILEINEK-LCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYE 257
+ L ++ ++++ LE + L +L E+ Q+ +S +E Q+ ++++ +
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE-----QIEELQRQKEHLTQDL 1653
Query: 258 ECKDLIKSMLRNER-QFKEEKLAEQLKQAEE-LRQYKVLVHSQERELTQLREKLREGRD- 314
E +D + ML+ ER Q E++ Q K EE L Q K+ + + RELT R+ ++E +
Sbjct: 1654 ERRDQ-ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
Query: 315 ------ASRSLNEHLQALLTPDEPD--------------------KSQG----------- 337
A R EH++ +L E + + QG
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Query: 338 ------------QDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR 385
Q LQE +G Q L +L D ++E ++ Q+ + +
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832
Query: 386 EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW 445
E + E+ + + +LE+ +T HG Q H++ EE+ L V+
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGEL---QDHKEQARRLEEE-----LAVEGRRVQ- 1883
Query: 446 EDAVHIIPENESDDEEEEEKG--PVSPRNLQESEEEEVP----QESWDEGYSTLSIPPER 499
A+ + + + E+EK + + ++++E EV Q+SW + + L +
Sbjct: 1884 --ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
Query: 500 LASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVL-Q 558
L + ++ S + EE A + QEA G + L KE +L Q
Sbjct: 1942 LEALRAESQSSRHQEEAARARAEAL------------QEALGK--AHAALQGKEQHLLEQ 1987
Query: 559 DSLDRCYSTPSVYLGLT-DSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCP 617
L R + L + D+CQ + + + E RI D+ +YQE + +
Sbjct: 1988 AELSRSLEASTATLQASLDACQAH--SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA 2045
Query: 618 RLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQ-----PYRSAVYSLEEQYLGLAL 672
+ EL ++E E L + + E +LGQ R S+ E L LA
Sbjct: 2046 QRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQ 2105
Query: 673 DVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPA-SPTE 731
I + +E ++ S + + E + DSL+ L L L A TE
Sbjct: 2106 KEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE--PRLQRELERLQAALRQTE 2163
Query: 732 VPFMHWRKNMLAFLLTWEKLKRRGRGRKE------------GEEDQRRKEEGE-EKKGKK 778
+ WR+ L+ + K +E E QR ++E E ++ +
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
Query: 779 IKTHHAPGSAA 789
+ H+PG+ +
Sbjct: 2224 KERLHSPGATS 2234
Score = 61.6 bits (148), Expect = 3e-09
Identities = 160/714 (22%), Positives = 269/714 (37%), Gaps = 133/714 (18%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHL-------QALLTPDEPDKSQGQ 67
E +Q V +Q L E LR R A + NE + QAL E +QG+
Sbjct: 1358 EHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGK 1417
Query: 68 DLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKA-------- 119
LQE LA L Q L+ +E E Q++E EK RE+QKA
Sbjct: 1418 ALQENLA-------LLTQTLAEREEEVETLRGQIQELEK------QREMQKAALELLSLD 1464
Query: 120 -----EESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHD 174
+E + ++ ++E C S+ H + + E K L V RE +
Sbjct: 1465 LKKRNQEVDLQQEQIQELE--------KCRSVLEHLPMAVQEREQK----LTVQREQIRE 1512
Query: 175 GCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSL 234
+D + NV E +LE+ EK + ++ Q + L
Sbjct: 1513 LEKD----------RETQRNV-------------LEHQLLEL-EKKDQMIESQRGQVQDL 1548
Query: 235 KEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLA----EQLKQAEELRQ 290
K K VT L ++N +K E + LIK L +R+ + L + ++++EL+
Sbjct: 1549 K-KQLVTLECLALELEENHHKMECQQKLIKE-LEGQRETQRVALTHLTLDLEERSQELQA 1606
Query: 291 YKVLVHSQERELTQLREKLREGRDASRSLNEHLQAL------LTPDEPDKSQGQDLQE-- 342
+H E T L +L+E +S E ++ L LT D + Q LQ+
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKER 1666
Query: 343 -QLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREM--QKAEEKEVP--- 396
Q+ E R Q + + +D E +++ + E+ ++ ++ R++ ++AEE + P
Sbjct: 1667 IQVLEDQRTRQTKILE-------EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 397 -EDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPEN 455
SLE + + + Q H ++ +D+++ L G V E
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIH-ELQELKDQLEQQLQGLHRKV---------GET 1769
Query: 456 ESDDEEEEEKGPVSPRNLQESEE-----EEVPQESWDEGYSTLSIPPERLASYQSYSSTF 510
+ E++ V + LQE+ E E+ Q DE L+ + L + Q
Sbjct: 1770 SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA 1829
Query: 511 HSLEEQQVCMAVDIGRHRWDQV---------KKEDQEATGPRLSRELLDEKE-----PEV 556
+E++V D + +Q + +D + RL EL E EV
Sbjct: 1830 QG-QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888
Query: 557 LQDSLDRCYSTPSVYLGLTDSC--QPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDP 614
L D L L C Q Q L E+ QE+E +
Sbjct: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948
Query: 615 SCPRLSRELLAEKEPEVLQDSLDRCYSTPSG----YLELPDLGQPYRSAVYSLE 664
S +E A E LQ++L + ++ G LE +L + ++ +L+
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQ 2002
Score = 45.1 bits (105), Expect = 3e-04
Identities = 85/398 (21%), Positives = 159/398 (39%), Gaps = 81/398 (20%)
Query: 14 TEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQL 73
++E+Q +H E T L +L+E D+ KSQ +EQ+
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARELQE-----------------RDQEVKSQ----REQI 1639
Query: 74 AEGCRLAQHLVQKLSPENDEDEDEDVQVEEDE-KVLESSAPREVQKAEESKVPEDSLEEC 132
E R +HL Q L E D+++ ++++ +VLE Q+ ++K+ E+ LE+
Sbjct: 1640 EELQRQKEHLTQDL-----ERRDQELMLQKERIQVLED------QRTRQTKILEEDLEQ- 1687
Query: 133 AITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSA 192
IK++ E L R+ + ++ P S
Sbjct: 1688 -------------------IKLSLRER--GRELTTQRQLMQERAEEGKG--PSKAQRGSL 1724
Query: 193 TNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQN 252
++ +++ E + +I E+ E L QL +QQ + L K T + +Q+
Sbjct: 1725 EHMKLILRDKEKEVECQQEHIHELQE-LKDQL---EQQLQGLHRKVGETSLLLSQREQEI 1780
Query: 253 KYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEEL---RQYKVLVHSQERELTQ-LREK 308
++ ++ R + + KE+ L QL +A+ R ++ QE++ Q E+
Sbjct: 1781 VVLQQQLQE-----AREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
Query: 309 LREGRDASRSLNEHLQALLTPD----EPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDN 364
++E DA + E L + K Q + L+E+LA R Q L + L
Sbjct: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG----- 1890
Query: 365 DDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEE 402
D + EK + + ++A+E EV +L++
Sbjct: 1891 --DLRAESREQEKALLALQQQCAEQAQEHEVETRALQD 1926
Score = 44.7 bits (104), Expect = 3e-04
Identities = 84/336 (25%), Positives = 137/336 (40%), Gaps = 39/336 (11%)
Query: 24 VHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQG----QDLQEQLAEGCRL 79
V S +L Q K ++ RD R + L+ LT E +KSQ QDLQ QL++
Sbjct: 1241 VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQN--- 1297
Query: 80 AQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECA--ITCS 137
Q K + + E E +++ E L+S R + E++ + L+ +T
Sbjct: 1298 -QEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
Query: 138 NSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSM 197
H ++ E + +S E + AL L S
Sbjct: 1357 VEH-----------LQAAVVEARAQASAAGILEEDLRTARSALK-LKNEEVESERERAQA 1404
Query: 198 VVSAGPLSSEKAEMNILEINEKLCPQ-LAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
+ G L + A+ L+ N L Q LAE++++ +L+ + L KQ+ K
Sbjct: 1405 LQEQGEL--KVAQGKALQENLALLTQTLAEREEEVETLRGQIQE------LEKQREMQKA 1456
Query: 257 E-ECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE---G 312
E L E ++E++ E K L + V +E++LT RE++RE
Sbjct: 1457 ALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD 1516
Query: 313 RDASRSLNEH-LQALLTPD---EPDKSQGQDLQEQL 344
R+ R++ EH L L D E + Q QDL++QL
Sbjct: 1517 RETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/201 (24%), Positives = 89/201 (44%), Gaps = 38/201 (18%)
Query: 207 EKAEMNILEINEKLCPQLAEKKQ-QFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKS 265
E E +E+ +L Q E + Q + +E+ C + + K E L+++
Sbjct: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK----ERVSLLET 933
Query: 266 MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT------------QLREKLREGR 313
+L+ +++ LA+ +Q E LRQ + +E+E T +L+E R+ R
Sbjct: 934 LLQTQKE-----LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 314 DASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVE 373
D +L E +LL + Q +DL+ QL +AQ Q+L V+ E
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLKSQL-----VAQDDSQRL-----------VEQE 1032
Query: 374 VAEKVQKSSSPREMQKAEEKE 394
V EK++++ +QK E+E
Sbjct: 1033 VQEKLRETQEYNRIQKELERE 1053
Score = 38.5 bits (88), Expect = 0.025
Identities = 55/217 (25%), Positives = 95/217 (43%), Gaps = 34/217 (15%)
Query: 204 LSSEKAEMNILEINEKLCPQLAEKKQQFRSLK-----------EKCFVTQVACFLAKQQN 252
L +EK +++LE + +LA+ QQ L+ E + Q A+++
Sbjct: 921 LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQREL 980
Query: 253 KYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQ-LREKLRE 311
K + +D + ++ ++K+ Q KQ E+L+ V +R + Q ++EKLRE
Sbjct: 981 KEAARQHRDDLAALQEESSSLLQDKMDLQ-KQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Query: 312 GRDASR--------------SLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQK 357
++ +R SL E Q LL E D + Q+L L + + AQ ++
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQEL-SALRQDMQEAQGEQKE 1098
Query: 358 LSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKE 394
LS + E ++ EV EK + +E Q EE E
Sbjct: 1099 LSAQM-----ELLRQEVKEK-EADFLAQEAQLLEELE 1129
Score = 32.7 bits (73), Expect = 1.3
Identities = 79/375 (21%), Positives = 128/375 (34%), Gaps = 35/375 (9%)
Query: 28 ERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKL 87
++ LT +R L R A + L + L + Q +E EG L Q L QKL
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE---EGKALRQRL-QKL 440
Query: 88 SPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQ 147
+ E D + V ++ + L + EE + + LE+ A
Sbjct: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV-------- 492
Query: 148 PHKNIKITFEEDKVNSSLVVDRESSH------DGCQDALNILPVPGPTSSATNVSM--VV 199
N+++ + D +E H + Q+ L L S + +++ +
Sbjct: 493 ---NVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549
Query: 200 SAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEEC 259
+ L E E+ L AE+ S E T+VA A E
Sbjct: 550 ESSHLEGELLRQEQTEVTAALAR--AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEA 607
Query: 260 KDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSL 319
L K L + EE+ + E Q + + E + RE L E
Sbjct: 608 LALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK------- 660
Query: 320 NEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQ 379
N HL+A L E G +LQ L + + + +KLS + Q+E +
Sbjct: 661 NTHLEAQLQKAE---EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717
Query: 380 KSSSPREMQKAEEKE 394
K + +EKE
Sbjct: 718 KRQEEVLARAVQEKE 732
Score = 31.2 bits (69), Expect = 3.9
Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 12 QPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQE 71
Q +E + +L + +L+E R+ RD +L E +LL + Q +DL+
Sbjct: 958 QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
Query: 72 QLA---EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQK 118
QL + RL + VQ+ E E ++E ++ L S + Q+
Sbjct: 1018 QLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQR 1067
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 58.9 bits (141), Expect = 2e-08
Identities = 130/686 (18%), Positives = 273/686 (39%), Gaps = 71/686 (10%)
Query: 28 ERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKL 87
E E +L EK +E ++ +SL + L T E + + L+E + E + K+
Sbjct: 1327 EMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRE-------TLAKI 1379
Query: 88 SPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAIT--CSNSHGPCDS 145
+ E E+D + + + E K ++S + +E ++ SH S
Sbjct: 1380 QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKS 1439
Query: 146 IQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLS 205
+ K+ +E V+ ES Q NI + T + V+ L
Sbjct: 1440 VAKEKDDLQRLQE-------VLQSESD----QLKENIKEIVAKHLE-TEEELKVAHCCLK 1487
Query: 206 SEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKS 265
++ +N L +N L+EK+ + ++++ Q+ K QNK I+
Sbjct: 1488 EQEETINELRVN------LSEKETEISTIQK-----QLEAINDKLQNK---------IQE 1527
Query: 266 MLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQA 325
+ E QF ++++E ++ EL+Q+K +++ L + K+ E + + E +Q
Sbjct: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 326 LLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPR 385
++ E K + LQ + + + +V K+ E+ + + +++ + Q+
Sbjct: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK-ESQEKEYQFLKMTAVNETQEKMCEI 1646
Query: 386 EMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEW 445
E K E+ E + +LE N ++ +T E D + S + + VE
Sbjct: 1647 EHLK-EQFETQKLNLENIETENIRLTQILHENLEEMRS-VTKERDDLRS--VEETLKVER 1702
Query: 446 EDAVHIIPENESDDEEEEEKGPVSPRNLQESEE-------------EEVPQESWDEGYST 492
+ + E + D E++E+ + +L+E +E E+ D +S
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
Query: 493 LSIPPERLASYQSYSSTFHSLEEQQ--VCMAVDIGRHRWDQVK--KEDQEATGPRLSREL 548
++ + L + L+EQQ + I + D++ ++D E + +L ++
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822
Query: 549 LDEKEPE----VLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDE-IE 603
+ K E L+ ++ S L + LE + + LA + E +E
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLE 1882
Query: 604 KYQEVEEDQDPSCPRLSRELLAEKE--PEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVY 661
+ + V +++D + R+ L E++ E LQ++ R L + ++ V
Sbjct: 1883 EMKSVMKERD-NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
Query: 662 SLEEQYLGLALDVDRIKKDQEEEEDQ 687
L E+ + + I+KD ++ +D+
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDE 1967
Score = 45.1 bits (105), Expect = 3e-04
Identities = 147/714 (20%), Positives = 275/714 (38%), Gaps = 93/714 (13%)
Query: 26 SQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQ 85
SQE+E L+ EHL+ E ++Q +L+ E RL Q L +
Sbjct: 1623 SQEKEYQFLKMTAVNETQEKMCEIEHLK------EQFETQKLNLENIETENIRLTQILHE 1676
Query: 86 KL------SPENDE--DEDEDVQVEEDE--KVLESSAPREVQKAEESKVPEDSLEECAIT 135
L + E D+ +E ++VE D+ + L + R+++K EE K+ L+E T
Sbjct: 1677 NLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQET 1736
Query: 136 CSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGC-------QDALNI--LPVP 186
G I E+ S++ D E S+D Q+ L I + +
Sbjct: 1737 IDKLRG------------IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK 1784
Query: 187 GPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKK---QQFRSLKEKCFVTQV 243
+ + +VS + ++ N KL ++ E K Q +LK+ TQ
Sbjct: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQK 1844
Query: 244 ACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELT 303
+++ + K + + L S L E +KL E L++ + + + + + E L
Sbjct: 1845 K--VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Query: 304 QLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND 363
R++L+E +++ + +Q L + ++ ++L E ++++ +Q + D
Sbjct: 1903 LERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE--KISEKTIQISDIQKD 1960
Query: 364 NDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEEC-----------AITCSNSHG 412
D +D E+ +K+Q+ +E+Q KE S ++ A S
Sbjct: 1961 LDKSKD---ELQKKIQELQK-KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSV 2016
Query: 413 PYDSNQPHRKTKITFEEDKV------DSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKG 466
D+ Q +K + EE ++ + I S +E + + + E + D + +
Sbjct: 2017 RMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ-- 2074
Query: 467 PVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGR 526
V P S+ ++ ES E S + E L Y + L + + +I
Sbjct: 2075 -VKPEKRLLSDGQQHLTESLREKCSRIK---ELLKRYSEMDDHYECLNRLSLDLEKEI-- 2128
Query: 527 HRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFY 586
+ +KE LS L K E L + RC + Y +
Sbjct: 2129 ----EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIK 2184
Query: 587 VLEQQRIG-LAVD-MDEIEKYQEVE---EDQDPSCPRLSRELLAEKE--------PEVLQ 633
+ + I +D +DE+EK +E+ + C SREL K E+L+
Sbjct: 2185 EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244
Query: 634 DSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQ 687
D + + PS E + + LEE +L D++++K ++E D+
Sbjct: 2245 DFSESEF--PSIKTEFQQVLSNRKEMTQFLEE-WLNTRFDIEKLKNGIQKENDR 2295
Score = 40.4 bits (93), Expect = 0.006
Identities = 79/395 (20%), Positives = 153/395 (38%), Gaps = 52/395 (13%)
Query: 30 ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP 89
E +L+EK++E + + +Q + E K DL+++L L +
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 90 ENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPH 149
+ +D ++++E L+ +EV++ E + EE + P + +
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALR------EEVILLSELKSLPSEVERLR 760
Query: 150 KNIK--------ITFEEDKVNSSLVVDRESSHDGCQDAL-----NILPVPGPTSSATNVS 196
K I+ IT E+DK+ S VV +ES G + + ++ S
Sbjct: 761 KEIQDKSEELHIITSEKDKLFSE-VVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF 819
Query: 197 MVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKY 256
+ E+ +LE NE++ Q+ +L ++ + K + YK
Sbjct: 820 QNFKTLHMDFEQKYKMVLEENERM-------NQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 257 EECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLR------ 310
+E ++ + + ER + E+L EQL+ + Q + ERE T + EKL+
Sbjct: 873 QELQEKTREV--QERLNEMEQLKEQLENRDSTLQ------TVEREKTLITEKLQQTLEEV 924
Query: 311 ----EGRDASRSLNEHLQ----ALLTPDEPDKSQGQDLQEQL---AEGCRLAQHLVQKLS 359
+ +D + L E LQ L + + D QEQL E + Q + L
Sbjct: 925 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984
Query: 360 PENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKE 394
+ + ++ +E K ++M ++K+
Sbjct: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQ 1019
Score = 37.4 bits (85), Expect = 0.055
Identities = 133/683 (19%), Positives = 266/683 (38%), Gaps = 126/683 (18%)
Query: 2 FSNSTGRLPGQ---PTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTP 58
F +S G L + T+E+Q+ V + E+ QL+E+L E RD++ E + L+T
Sbjct: 857 FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL-ENRDSTLQTVEREKTLIT- 914
Query: 59 DEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDED--EDVQVEEDE--KVLESSAPR 114
+ LQ+ L E V+ L+ E D+ + E +Q+E D+ + +
Sbjct: 915 --------EKLQQTLEE--------VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNM 958
Query: 115 EVQKAEESKVPEDSLEECAITCSNSHGPCD---SIQPHKNIKITFEEDKVNSSLV-VDRE 170
+ E+ + +SL++ T + S H +D+ +V +D++
Sbjct: 959 NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018
Query: 171 SSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEM-----NILEINEKLCPQLA 225
+A N + + L EK E+ +++ E+L L
Sbjct: 1019 QD----LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074
Query: 226 E-------------------KKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSM 266
E KKQQ +EK + L++ ++ E K KS
Sbjct: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134
Query: 267 LRNERQFK----EEKLAEQLKQAEELRQYK-------VLVHSQERELTQLREKLREGRDA 315
E+Q + +E+++E K+ E+ K + + E E +L +KL E +
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194
Query: 316 SRSLNEHLQALLTPDEPDKSQGQDLQEQLAE----GCRLAQHL-VQKLSPENDNDDDEDV 370
+S+ + + L + +++ L+ + E G + + L + + + + +++
Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1254
Query: 371 QVEVAEKVQKSSSPREMQKAEEK---EVPEDSLEECAITCSNSHGPYDSNQPHRKTKITF 427
+ V+EK + + ++++K+ K E+P L E N ++ + + ++
Sbjct: 1255 RRSVSEKTAQIINTQDLEKSHTKLQEEIP--VLHEEQELLPNVKEVSETQETMNELELLT 1312
Query: 428 EEDKV-DSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPR--NLQESEEE-EVPQ 483
E+ DST + + +E E + NE E +EE ++ NL+ +E EV
Sbjct: 1313 EQSTTKDSTTL---ARIEMER----LRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365
Query: 484 ESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPR 543
+ E E LA Q S +EQ + M K++D E T
Sbjct: 1366 DQLKEHIR------ETLAKIQESQSK----QEQSLNM------------KEKDNETTKIV 1403
Query: 544 LSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIE 603
E K+ +L+ ++ LGL+ Q + +A + D+++
Sbjct: 1404 SEMEQFKPKDSALLRIEIE--------MLGLSKRLQE-------SHDEMKSVAKEKDDLQ 1448
Query: 604 KYQEVEEDQDPSCPRLSRELLAE 626
+ QEV + + +E++A+
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAK 1471
Score = 35.8 bits (81), Expect = 0.16
Identities = 76/387 (19%), Positives = 155/387 (40%), Gaps = 26/387 (6%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE++ + QE + +LR L E ++ + L+A+ LQ ++
Sbjct: 1477 EELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI----------NDKLQNKIQ 1526
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPR-EVQKAEESKVPEDSLEECA 133
E + K E E +E Q +E K +S+ E + E + ++S EE
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 134 ITCSNSHGPCDSIQPHKNIKITFEEDKVNS-SLVVDRESSHDGCQDALNILPVPGPTSSA 192
I + + + ++I ++ K N+ +V + S + L + V
Sbjct: 1587 IMIKEKE---EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643
Query: 193 TNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSL-KEKCFVTQVACFLAKQQ 251
+ + E NI N +L L E ++ RS+ KE+ + V L ++
Sbjct: 1644 CEIEHLKEQFETQKLNLE-NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVER 1702
Query: 252 NKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEE-LRQYKVLVHSQERELTQLREKLR 310
++ K E ++ I L + + K + LK+ +E + + + +V + E++ +++ L
Sbjct: 1703 DQLK-ENLRETITRDLEKQEELKIVHM--HLKEHQETIDKLRGIVSEKTNEISNMQKDLE 1759
Query: 311 EGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDV 370
DA ++ + +Q L + Q+ ++L + KLS N D E+
Sbjct: 1760 HSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR---GIVSEKTDKLS--NMQKDLENS 1814
Query: 371 QVEVAEKVQKSSSPREMQKAEEKEVPE 397
++ EK+Q+ + +K+V E
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNE 1841
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 58.5 bits (140), Expect = 2e-08
Identities = 172/818 (21%), Positives = 318/818 (38%), Gaps = 111/818 (13%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLR-EGRDASRSLNEHLQALLTPDEPDKSQGQDLQE-- 71
EE +Q + +E+EL L E+ + + R+ ++ L E L E +SQ Q +
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 72 --QLAEGCRLAQH-------LVQKLSPEND--EDEDEDVQVEEDEKVLESSAPRE----- 115
QL E + +H L ++L E ++E+E++Q EE EK R+
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934
Query: 116 -VQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSH- 173
+Q+ EE + E+ + + +Q + + E +K +RE +
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ---EREKKYR 991
Query: 174 ---DGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQ 230
+ Q+ +L ++ E + E EK +L E+++Q
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR--RLQERERQ 1049
Query: 231 FRS-----LKEKCFVTQVACFLAKQQNKYKY---EECKDLIKSMLRNERQFKEEKLAE-Q 281
+R +E+ + + +Q+ + +Y EE + + +LR E + + + E Q
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109
Query: 282 LKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQ 341
++ EEL+Q + + +ERE + +E R+ R+ E Q L +EP+K + Q+L+
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR--EEPEKRRRQELE 1167
Query: 342 EQLAEGCRLAQHLVQKLSPENDND---------DDEDVQVEVAEKVQKSSSPREMQKAEE 392
Q E L Q Q L E + ++E++Q + ++ + R K +
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Query: 393 KEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHII 452
+ E+++ + + C N+ R+ + DS L S +D H++
Sbjct: 1228 EPEKENAVRDNKVYCKGRE-----NEQFRQLE--------DSQLRDRQSQ---QDLQHLL 1271
Query: 453 PENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHS 512
E + D E+E + R+ EEE++ +E E S +
Sbjct: 1272 GEQQERDREQERRR-WQQRDRHFPEEEQLEREEQKEAKR------RDRKSQEEKQLLREE 1324
Query: 513 LEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK--EPEVLQDSLDRCYSTPSV 570
EE++ D +Q+ +E +E L R+ D K E E+ R +
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQP---LRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 571 YLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPE 630
L + + + L Q + D K++E E+Q S R+ E+E +
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE--EEQQLSRQERDRKF-REEEQQ 1438
Query: 631 VLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPP 690
V + +R +LE + R + EEQ L QE EE Q
Sbjct: 1439 VRRQERER------KFLEEEQQLRQERHRKFREEEQLL------------QEREEQQ--- 1477
Query: 691 CPRLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPASP--TEVPFMHWRKNMLAFLLTW 748
R R+ + E + L+ + L S P E +H ++ FL
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 749 EKLKRRGRG--------RKEGEEDQRRKEEGEEKKGKK 778
++L+R+ RG RK EE+Q R+E E++ ++
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575
Score = 58.2 bits (139), Expect = 3e-08
Identities = 167/808 (20%), Positives = 298/808 (36%), Gaps = 102/808 (12%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE +Q ++ +ER L ++L+ E + L +EP++ + Q QL
Sbjct: 583 EERRQQRLKREQEER----LEQRLKREEVERLEQEERREQRLKREEPEEERRQ----QLL 634
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPRE-VQKAEESKVPEDSLEECA 133
+ + Q+L E E ++ ++ EE+E+ LE RE ++ E ++ E+ E+
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ-- 692
Query: 134 ITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSAT 193
+ S P ++ E D S V R +G + S
Sbjct: 693 -----ARERIKSRIPKWQWQLESEAD-ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746
Query: 194 NVSMVVSAGPLSSE-----------KAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQ 242
A E +AE ++L + ++Q+ R L+ + +
Sbjct: 747 QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 243 VACFLAKQQNK-----YKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEE-LRQYKVLVH 296
FL +++ K + E K+L L E Q + + A+QL++ E+ L++ +
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKEL--QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 297 SQER--------ELTQLREKLREGRDASRSLNEHL---QALLTPDEPDKSQGQDLQEQLA 345
SQE+ +L + R++ R A +L E L Q LL +E ++LQ +
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE------EELQREER 918
Query: 346 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAI 405
E R + Q E ++E + E EK ++ R+ +K ++ + E+ L
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL----- 973
Query: 406 TCSNSHGPYDSNQPHRKTKITFEED--KVDSTLIGSS----SHVEWEDAVHIIPENESDD 459
P + R+ K EE+ + + L+ EWE E + ++
Sbjct: 974 ---LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 460 E----EEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEE 515
E EE EK + R Q EEEE+ QE + Q EE
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 516 QQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLT 575
+Q+ R R ++ ++ +E + +LL E+ + + L+R Y
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE------ 1144
Query: 576 DSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDS 635
++Q+ L + E + QE+E R EL E+E + ++
Sbjct: 1145 -----------EVQQEEEQLLREEPEKRRRQELERQY-----REEEELQQEEEQLLREEQ 1188
Query: 636 LDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLS 695
R Y E +L + R Y E+Q L + K + D C
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK--ENAVRDNKVYCKGRE 1246
Query: 696 RELLEVVEPEVLQDSLDVIQLLPVVLNSLTPASPTEVPFMHWRKNMLAF-----LLTWEK 750
E +E L+D L ++ E W++ F L E+
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLL--GEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 751 LKRRGRGRKEGEEDQRRKEEGEEKKGKK 778
+ + R RK EE Q +EE EEK+ ++
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Score = 46.2 bits (108), Expect = 1e-04
Identities = 143/777 (18%), Positives = 291/777 (37%), Gaps = 120/777 (15%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 74
EE+QQ + + +ERE + +E R+ R+ E Q L +EP+K + Q+L+ Q
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR--EEPEKRRRQELERQYR 1171
Query: 75 EGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVP--------- 125
E L Q Q L E ++ E + +E+ L+ ++ + E+ +
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Query: 126 EDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPV 185
E+++ + + C +N + ED S + DR+S QD ++L
Sbjct: 1232 ENAVRDNKVYCKG----------RENEQFRQLED----SQLRDRQSQ----QDLQHLL-- 1271
Query: 186 PGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVAC 245
G E LE E Q K++ +S +EK + +
Sbjct: 1272 -GEQQERDREQERRRWQQRDRHFPEEEQLEREE----QKEAKRRDRKSQEEKQLLRE--- 1323
Query: 246 FLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKV--LVHSQE-REL 302
+++ K + +E R E Q +E+ + L++ E R+++ L H ++ R+
Sbjct: 1324 ---EREEKRRRQETD----RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKF 1376
Query: 303 TQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEN 362
+ ++LR + L E Q E Q +D + + E Q +K E
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 363 DNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRK 422
++ + + E+ Q+ R + EE+++ ++ E+ Q HR+
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ---------------QLHRQ 1481
Query: 423 TK-ITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEV 481
+ F E++ ++ PE + +EE++ R + E++
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 482 PQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQ--VKKEDQEA 539
QE + +R ++ EEQQ+ + R ++ V++++QE
Sbjct: 1542 RQERGQQRRQ------DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 540 TGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVD- 598
++L ++ + L+ DR + L + Q +R E+ R L +
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ-----ERDRKFLEEEP 1650
Query: 599 -MDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYR 657
+ E+ Q++ D+D + L +E ++ + DR + E L + R
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE-----EEQQLRRQER 1705
Query: 658 SAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDVIQLL 717
+ EEQ L + +++++ ++ R +++E E L+ +
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE---- 1761
Query: 718 PVVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRGRGRKEGEEDQRRKEEGEEK 774
++L+R+ R RK EE+Q R+E E++
Sbjct: 1762 -------------------------------QQLRRQERDRKFREEEQLRQEREEQQ 1787
Score = 45.4 bits (106), Expect = 2e-04
Identities = 116/555 (20%), Positives = 225/555 (40%), Gaps = 55/555 (9%)
Query: 268 RNERQFKEEKLAEQLKQAEELRQYKVLVHSQ-ERELTQLREKLREGRDASRSLNEHLQAL 326
R +RQ +E +LAE +Q+E+ + + + + EL + R++ +E R+ R+ E LQ+
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE-REERRAEEEQLQSC 196
Query: 327 L---TPDEPDKSQGQDLQ---------EQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEV 374
T + PD+ Q + + E+ + R Q V + E + E V +
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKE 256
Query: 375 AEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITF--EEDKV 432
EK+Q+ R+ + EE+E LE + + R+ ++ EE++
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLR-KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 433 DSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYST 492
+ E + ++EE + + +E E+++ +E +E
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 493 LSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK 552
++L Q EQQ+ + R + Q+++E Q +L RE +E+
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ--QLRREQQLRREQQLRREQEEER 433
Query: 553 -----EPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEI--EKY 605
E E + L R +L + + + E+++ L D +E E++
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQ-----ERRKQQLKRDQEEERRERW 488
Query: 606 QEVEED-----QDPSCPRLSRELLAEKEPEVL-QDSLDRCYSTPSGYLELPDLGQPYRSA 659
++EE+ Q+ +L RE +E + Q+ +R +L + R
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 660 VYSLEEQY-LGLALDVDRIKKDQEEEEDQ------GPPCPRLSRELLEVVEPEVLQDSLD 712
+ EE+ L R+K++QEE DQ RL RE E +E + ++ ++
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 713 VIQLLPVVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLKRRG----RGRKEGEEDQRRK 768
++ L P E R+ L L + E+ +RR R ++E E + ++
Sbjct: 609 RLEQEERREQRLKREEPEEE-----RRQQL--LKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 769 EEGEEKKGKKIKTHH 783
EE EE+ +++K H
Sbjct: 662 EEEEERLEQRLKREH 676
Score = 45.4 bits (106), Expect = 2e-04
Identities = 110/570 (19%), Positives = 208/570 (36%), Gaps = 52/570 (9%)
Query: 226 EKKQQFRSLKEKCFVTQV-------ACFLAKQQNKYKYE------ECKDLIKSMLRNERQ 272
EK+QQ R +++ F + L K++ K + E E ++ + + + ERQ
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 273 FKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEP 332
+ E+ +Q + LR+ + L QE E + +E+ RE ++ E + L ++
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 333 DKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEE 392
++ + Q +EQ E Q+L E + + E + ++ RE Q E
Sbjct: 345 ERREQQLRREQEEE------RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Query: 393 KEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHII 452
+++ + Q R+ + E K + E E+ +
Sbjct: 399 QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL 458
Query: 453 PENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHS 512
E + E+E+ + QE E E + +E E+ +
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518
Query: 513 LEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSVYL 572
L+ Q+ + Q+++E +E L RE E E + L R L
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 573 GLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVL 632
L + + +++R+ + +E+E+ ++ E + RL RE E E E
Sbjct: 579 -LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ----RLKRE---EPEEERR 630
Query: 633 QDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCP 692
Q L +L Q R EE+ L R+K++ EEE
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE---QRLKREHEEE-------- 679
Query: 693 RLSRELLEVVEPEVLQDSLDVIQLLPVVLNSLTPASPTEVPFMHWRKNMLAFLLTWEKLK 752
R +EL E + + + I L S A ++V K
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV--------------YSRPRK 725
Query: 753 RRGRGRKEGEEDQRRKEEGEEKKGKKIKTH 782
+ G+ R++ +E++RR+ E E + ++ + H
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAH 755
Score = 40.8 bits (94), Expect = 0.005
Identities = 89/435 (20%), Positives = 167/435 (38%), Gaps = 71/435 (16%)
Query: 15 EEIQQYKVLVHSQERELTQLREKLREGR----DASRSLNEHLQALLTPDEPDKSQGQDLQ 70
EE QQ + H + RE QL ++ E + + R E Q L + K + Q+L+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLE 130
Q E L + + E+ Q+ E+ + R+ + EE ++ ++ E
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE 1569
Query: 131 ECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTS 190
+ + ++ K EE KV +E +D + G
Sbjct: 1570 Q------------QLSRQERDRKFRLEEQKVRR-----QEQERKFMEDEQQLRRQEGQQQ 1612
Query: 191 SATNVSMVVSAGPL---SSEKAEMNILEINEKLC---PQLA--EKKQQFRSLKEKCFVTQ 242
E+ +++ E + K PQL E++QQ R +++ F +
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 243 VACF-------LAKQQNKYKYEECKDLI------KSMLRNERQFKEEKLAEQLKQAEELR 289
L +Q+ K+ E + + + L+ E+Q + ++L + ++ E+LR
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 290 Q-------------YKVLVHSQ---ERELTQLR--EKLREGRDASRSLNEHLQALLTPDE 331
Q K+L Q ERE QLR E+ R+ R+ + E + L E
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQE 1792
Query: 332 PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDND----DDEDVQVEVAEKVQKSSSPREM 387
D+ + +EQL + + Q+L P+ + ++E +Q+E E+ + R+
Sbjct: 1793 SDRKFRE--EEQLRQ-----EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQY 1845
Query: 388 QKAEEKEVPEDSLEE 402
+ E+ E S E
Sbjct: 1846 RAEEQFATQEKSRRE 1860
Score = 38.1 bits (87), Expect = 0.032
Identities = 70/354 (19%), Positives = 139/354 (39%), Gaps = 46/354 (12%)
Query: 224 LAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLK 283
L E++Q R +++ F Q L Q+ + K+ E + + R + +EE+ + +
Sbjct: 1488 LEEEQQLRRQERDRKFREQE---LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 284 QAEELRQYKVLVHSQERELTQLREK---LREGRDASRSLNEHL-------------QALL 327
+ ++ RQ + +E +L Q RE+ R+ RD L E + L
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Query: 328 TPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDD---DEDVQVEVAEKVQKSSSP 384
E + Q+ + E +L Q ++ + D +E+ Q+ E+ Q+
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664
Query: 385 REMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQ----PHRKTKITFEEDKVDSTLIGSS 440
R+ + EE+++ ++ E+ + Q R+ K EE ++ +
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724
Query: 441 SHVE--------------WEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESW 486
E E I+ E + E EE++ R+ + EEE++ QE
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 487 DEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRW--DQVKKEDQE 538
++ + E ++ EEQQ+ G++RW +Q++ E+QE
Sbjct: 1785 EQQLRS----QESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834
Score = 37.4 bits (85), Expect = 0.055
Identities = 103/566 (18%), Positives = 206/566 (36%), Gaps = 80/566 (14%)
Query: 25 HSQERELTQLREKLREGRD-------ASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGC 77
H QER +L+ + E RD R E + L D+ ++ + + L+ + E
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Query: 78 RLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSL----EECA 133
+ Q+L E +E ++ ++ +E+E+ L+ E Q E + + L EE
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 134 ITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSAT 193
+ Q + ++ E+++ L+ E
Sbjct: 558 LE-----------QERREQRLKREQEERRDQLLKREEERRQQ------------------ 588
Query: 194 NVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNK 253
L E+ E + + +L +++++ + LK + + ++Q
Sbjct: 589 ---------RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE------RRQQL 633
Query: 254 YKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLRE-G 312
K EE ++ + LR E+Q + E+ ++ ++ E L Q H +ER +L E+ +E
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693
Query: 313 RDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQK---LSPENDNDDDED 369
R+ +S Q L + + + + EG R Q +K E ++E
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 370 VQVEVAEKVQKSSSPREMQKAEEKEVPEDSLE-ECAITCSNSHGPYDSNQPHRKTKITFE 428
+ E+ Q+ + Q E+ E L + + R+ + E
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 429 EDKVDSTLIGSSSHVEWEDAVHIIPENE-------SDDEEEEEKGPVSPRNLQESEEEEV 481
E++ + E E + + E E + +EEE G LQE +E
Sbjct: 814 EEEKEQR---RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG------LQEDQERRR 864
Query: 482 PQESWDEGYSTLSIPPERL----ASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQ 537
QE + + ER Y + +EQQ+ + R ++ K+ Q
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 538 EATGPRLSRELLDEKEPEVLQDSLDR 563
E E L ++E ++L++ ++
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREK 950
Score = 33.1 bits (74), Expect = 1.0
Identities = 24/108 (22%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 15 EEIQQYKVLVHSQER----ELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQ 70
EE Q+ + L +E+ E +LR + +E + L Q +E + Q ++ +
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 71 EQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQK 118
EQ + + Q+L E +E ++ ++ E++E+ E RE ++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Score = 32.0 bits (71), Expect = 2.3
Identities = 87/479 (18%), Positives = 188/479 (39%), Gaps = 60/479 (12%)
Query: 226 EKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLAE---QL 282
E++Q R +E+ F+ + ++ K++ EE + + RQ ++ K E QL
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494
Query: 283 KQAE---ELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQD 339
++ E + R+ ++ ER+ + ++L + + L E Q L E + + QD
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ--LRRQERGQQRRQD 1552
Query: 340 LQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDS 399
+ E +L Q ++ + D ++ +KV++ R+ + E++ ++
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLE---EQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 400 LEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDD 459
++ + R+ + +++ D + + ++ + +
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQER-DRKFLEEEPQLRRQEREQQLRHDRDRK 1668
Query: 460 EEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVC 519
EEE + LQE EE+++ ++ D + EEQQ+
Sbjct: 1669 FREEE------QLLQEGEEQQLRRQERDRKFRE---------------------EEQQLR 1701
Query: 520 MAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKE--PEVLQDSLDRCYSTPSVYLGLTDS 577
+ R + +E+Q+ L R+ +E++ E Q+ L R + +
Sbjct: 1702 R-----QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL--EEEQ 1754
Query: 578 CQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQDPSCPRLSRE---LLAEKEPEVLQ- 633
+P R + Q+R + +++ + +E ++ + R RE L E+E + L+
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Query: 634 DSLDRCYSTPSGYLELPDLGQ---PYRSAVYSLEEQYLGLALDVDRIKKDQE--EEEDQ 687
D Y L+L + Q R Y EEQ+ A +++QE +EE+Q
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF---ATQEKSRREEQELWQEEEQ 1870
>gi|154813191 IQ motif containing E isoform 1 [Homo sapiens]
Length = 695
Score = 57.8 bits (138), Expect = 4e-08
Identities = 90/417 (21%), Positives = 171/417 (41%), Gaps = 56/417 (13%)
Query: 3 SNSTGRLPGQPT--------EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQA 54
S S G +PG P +EI + K +H Q+ ++ +R KLR + + + ++
Sbjct: 128 SASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQ 187
Query: 55 LLTPDEPDKSQGQDLQEQLAE----GCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLES 110
LL P S+G D LAE + L Q++ + +++D + + + +++
Sbjct: 188 LLDP-----SRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKT 242
Query: 111 SAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRE 170
+ E++ A E+ E + + S + G + K + K+ S+L+
Sbjct: 243 TNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAK---RQKKMGSALLSLSR 299
Query: 171 SSHDGCQDALNIL-PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKK- 228
S + ++ ++ + S++ +S S + I+E+ +KL + K
Sbjct: 300 SVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSH 359
Query: 229 --QQFRSLKEKCFVTQVACFLAKQQNKYK-YEECKDLIKSMLRNERQFKEEKLAEQLKQA 285
+ RS C + A + ++ K +E + ++ L+ ER +E+L ++ +
Sbjct: 360 AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD-LKEERTALQEQLLQRDLEV 418
Query: 286 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 345
++L Q K E+EL RE E R+ L E +Q L S+ Q+LQE
Sbjct: 419 KQLLQAKA---DLEKELECAREGEEERREREEVLREEIQTL-------TSKLQELQEMKK 468
Query: 346 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEE 402
E + ED EV K Q+ +P + E++ P DS EE
Sbjct: 469 E-------------------EKEDCP-EVPHKAQELPAPTPSSRHCEQDWPPDSSEE 505
>gi|154813193 IQ motif containing E isoform 2 [Homo sapiens]
Length = 679
Score = 57.8 bits (138), Expect = 4e-08
Identities = 90/417 (21%), Positives = 171/417 (41%), Gaps = 56/417 (13%)
Query: 3 SNSTGRLPGQPT--------EEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQA 54
S S G +PG P +EI + K +H Q+ ++ +R KLR + + + ++
Sbjct: 112 SASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQ 171
Query: 55 LLTPDEPDKSQGQDLQEQLAE----GCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLES 110
LL P S+G D LAE + L Q++ + +++D + + + +++
Sbjct: 172 LLDP-----SRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKT 226
Query: 111 SAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRE 170
+ E++ A E+ E + + S + G + K + K+ S+L+
Sbjct: 227 TNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAK---RQKKMGSALLSLSR 283
Query: 171 SSHDGCQDALNIL-PVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKK- 228
S + ++ ++ + S++ +S S + I+E+ +KL + K
Sbjct: 284 SVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSH 343
Query: 229 --QQFRSLKEKCFVTQVACFLAKQQNKYK-YEECKDLIKSMLRNERQFKEEKLAEQLKQA 285
+ RS C + A + ++ K +E + ++ L+ ER +E+L ++ +
Sbjct: 344 AAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD-LKEERTALQEQLLQRDLEV 402
Query: 286 EELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLA 345
++L Q K E+EL RE E R+ L E +Q L S+ Q+LQE
Sbjct: 403 KQLLQAKA---DLEKELECAREGEEERREREEVLREEIQTL-------TSKLQELQEMKK 452
Query: 346 EGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEE 402
E + ED EV K Q+ +P + E++ P DS EE
Sbjct: 453 E-------------------EKEDCP-EVPHKAQELPAPTPSSRHCEQDWPPDSSEE 489
>gi|7657138 golgi integral membrane protein 4 [Homo sapiens]
Length = 696
Score = 57.4 bits (137), Expect = 5e-08
Identities = 121/590 (20%), Positives = 230/590 (38%), Gaps = 76/590 (12%)
Query: 15 EEIQQYKVLVHSQERE-----LTQLREKLREGRDASRS----LNEHLQALLTPDEPDKSQ 65
E+ Q + L H + +E + +E L +GR S S LN Q L + E K Q
Sbjct: 72 EKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQ 131
Query: 66 GQDLQE----QLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEE 121
DL+E Q + R QK E E E +++E L R+++KA +
Sbjct: 132 HSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREEN-RQLRKAHQ 190
Query: 122 SKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALN 181
L++ N + H+ + +T E+ K + + + + +D LN
Sbjct: 191 DI--HTQLQDVKQQHKNL------LSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLN 242
Query: 182 ILPV-----PGPTSSATNVSMVVSAGPLSSEKAEMNILEI--------NEKLCPQLAEKK 228
+P P + T V+ + EK + E+ N + P AE
Sbjct: 243 RIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDT 302
Query: 229 QQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNE-RQFKEEKLAEQLKQAEE 287
+ + ++ A F A + + E ++ + + E R+ EE+ EQ+ QAE
Sbjct: 303 KLYAPTHKE------AEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEH 356
Query: 288 LRQ-YKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAE 346
L + + Q+RE + E+ R+A+ L H +A + P + Q E+ E
Sbjct: 357 LEEEHDPSPEEQDREWKEQHEQ----REAANLLEGHARAEVYPSAKPMIKFQSPYEEQLE 412
Query: 347 GCRLAQHLVQKLSPENDNDD--------------DEDVQVEVAEKV--QKSSSPREMQKA 390
RLA V++ ++ + E Q +VA ++ Q+ + E +
Sbjct: 413 QQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQ 472
Query: 391 EEKEVPE----DSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWE 446
++++ + D+++ + + G + + +E + D G+ +
Sbjct: 473 HQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDP---GNRHEPREQ 529
Query: 447 DAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSY 506
PE+E+D E+ P N Q +E E ++ +E ++P E QS
Sbjct: 530 GPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREE-----NLPDENEEQKQSN 584
Query: 507 SSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEV 556
++ E+ + MA + + D V ++ QE + +L +EK+ E+
Sbjct: 585 QKQENTEVEEHLVMAGNPDQQE-DNVDEQYQEEAEEEVQEDLTEEKKREL 633
Score = 56.6 bits (135), Expect = 9e-08
Identities = 101/508 (19%), Positives = 198/508 (38%), Gaps = 69/508 (13%)
Query: 18 QQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGC 77
Q+Y L +E+EL++L+E + R+ +R L + Q + T Q QD+++Q
Sbjct: 155 QKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHT-------QLQDVKQQHKNLL 207
Query: 78 RLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCS 137
+ LV L QV E +++ ++ + + + P D E+ +T
Sbjct: 208 SEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDT-----LNRIPSLRKP-DPAEQQNVT-Q 260
Query: 138 NSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSM 197
+H P + +E N+ + + E+ +D + PT
Sbjct: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDT----KLYAPTHKEAEFQA 316
Query: 198 VVSAGPLSSEKAEMNILEINEKLCPQLAEKK-------------------QQFRSLKEKC 238
E+ E ++ E+ L E++ +Q R KE+
Sbjct: 317 PPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQH 376
Query: 239 FVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKLA-EQLKQAEELRQYKVLVHS 297
+ A L Y K +IK E Q ++++LA +Q+++A++LR+++ +H
Sbjct: 377 EQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQ 436
Query: 298 QERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQK 357
Q + LR++ ++ + +R + QA L E + Q Q+ Q A + +VQ
Sbjct: 437 QRLQGHLLRQQEQQQQQVAREMALQRQAEL---EEGRPQHQEQLRQQAHYDAMDNDIVQG 493
Query: 358 LSP----------ENDNDDDEDVQVEVAEKVQ-KSSSPREMQKAEEKE------------ 394
E DN ++ + + + + + PRE E +
Sbjct: 494 AEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADD 553
Query: 395 ---VPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHI 451
ED EE A + P D N+ +++ E +V+ L+ + + + ED V
Sbjct: 554 PNNQGEDEFEE-AEQVREENLP-DENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDE 611
Query: 452 IPENESDDEEEEEKGPVSPRNLQESEEE 479
+ E+++E +E+ R L+ + EE
Sbjct: 612 QYQEEAEEEVQEDLTEEKKRELEHNAEE 639
Score = 43.9 bits (102), Expect = 6e-04
Identities = 100/524 (19%), Positives = 187/524 (35%), Gaps = 99/524 (18%)
Query: 16 EIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAE 75
E +Q V + + L + ++ E + +LN + +L PD P + Q +
Sbjct: 209 EHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNR-IPSLRKPD-PAEQQNVTQVAHSPQ 266
Query: 76 GCRLAQHL----VQKLSPEND----------EDEDEDVQVEEDEKVLESSAPREVQKAEE 121
G A+ VQ++S ND ED + ++ + P +Q+ E
Sbjct: 267 GYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVE 326
Query: 122 SKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQ-DAL 180
+ PE+ E + + + +++ EE+ S DRE Q +A
Sbjct: 327 RREPEEHQVEEEHRKALEEEEMEQVGQAEHL----EEEHDPSPEEQDREWKEQHEQREAA 382
Query: 181 NILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLCPQLAEKKQQFRSLKEKCFV 240
N+L + SA P+ ++ ++L Q E+ QQ R +E
Sbjct: 383 NLL------EGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQ 436
Query: 241 TQVACFLAKQQNKYKYEECKDLI---KSMLRNERQFKEEKLAEQLK-------------- 283
++ L +QQ + + + +++ ++ L R +E+L +Q
Sbjct: 437 QRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAED 496
Query: 284 ---QAEELRQYKVLVHSQERELT--QLREKLREG-------RDASRSLNEHLQALLTPDE 331
Q EE + H E E E +G +A R+ E + P+
Sbjct: 497 QGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNN 556
Query: 332 -----------------PDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDD-DEDVQVE 373
PD+++ Q Q E + +HLV +P+ D+ DE Q E
Sbjct: 557 QGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEE 616
Query: 374 VAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVD 433
E+VQ +++ E+ E ++G D N + +E + D
Sbjct: 617 AEEEVQ-------------EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
Query: 434 STLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESE 477
+ G H E ++EEEE+ V+ ++ + +E
Sbjct: 664 NRPKGREEHY------------EEEEEEEEDGAAVAEKSHRRAE 695
Score = 39.3 bits (90), Expect = 0.014
Identities = 96/497 (19%), Positives = 188/497 (37%), Gaps = 77/497 (15%)
Query: 213 ILEINEKLCPQLAEKKQQFRSLKEKCFV----TQVACFLAKQQNKYKYEECK---DLIKS 265
+ E +L L +++ + + KE V Q +Q + +Y ++KS
Sbjct: 64 VYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKS 123
Query: 266 MLRNERQFKEEKLAEQLKQAEEL--------RQYKVLVHSQERELTQLREKLREGRDASR 317
++ + E KQ E+ ++Y L +E+EL++L+E + R+ +R
Sbjct: 124 QHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENR 183
Query: 318 SLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEK 377
L + Q + T + K Q ++L L++H ++ E+ Q +VAE
Sbjct: 184 QLRKAHQDIHTQLQDVKQQHKNL---------LSEHEQLVVTLEDHKSALAAAQTQVAEY 234
Query: 378 VQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLI 437
Q + + + D E+ +T +H P N K T E +V
Sbjct: 235 KQLKDTLNRIPSLRK----PDPAEQQNVT-QVAHSPQGYNTAREKP--TREVQEV----- 282
Query: 438 GSSSHVEWEDAVHIIPENESDDE-----EEEEKGPVSPRNLQESEEEEVPQESWDEGYST 492
S ++ W++ +P D + +E + P +Q+ E P+E E
Sbjct: 283 -SRNNDVWQNH-EAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVE---- 336
Query: 493 LSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEK 552
+ + E +QV A + +++D+E +E +++
Sbjct: 337 -----------EEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDRE------WKEQHEQR 379
Query: 553 EPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRIGLAVDMDEIEKYQEVEEDQ 612
E L + R PS + PY LEQQR+ + ++E+ Q++ E Q
Sbjct: 380 EAANLLEGHARAEVYPSA-KPMIKFQSPYEEQ---LEQQRLA----VQQVEEAQQLREHQ 431
Query: 613 DP-SCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLA 671
+ RL LL ++E + Q + + + E G+P + Y +
Sbjct: 432 EALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEE----GRPQHQEQLRQQAHYDAMD 487
Query: 672 LDVDRIKKDQEEEEDQG 688
D+ + +DQ + ++G
Sbjct: 488 NDIVQGAEDQGIQGEEG 504
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 56.2 bits (134), Expect = 1e-07
Identities = 103/507 (20%), Positives = 198/507 (39%), Gaps = 64/507 (12%)
Query: 40 EGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP-----ENDED 94
E D S+ + E + + + D+S + LQ R Q QK P +ED
Sbjct: 166 EDEDNSKKIKERSRINSSGESGDESD-EFLQS------RKGQKKNQKNKPGPNIESGNED 218
Query: 95 EDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKI 154
+D +++ + RE +K +E K L+E G D + K +
Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE---ELETGKKDQSK-QKESQR 274
Query: 155 TFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNIL 214
FEE+ V S + VD ++P + + + G + +
Sbjct: 275 KFEEETVKSKVTVDT-----------GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG 323
Query: 215 EINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLIKSMLRNERQFK 274
E EK EK+++ K Q A K++ + + E ++ IK + E + K
Sbjct: 324 EKEEK------EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRK 377
Query: 275 EEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQA--LLTPDEP 332
EE+ EQ K+ + ++ K ++E L + RE R + + + LQA + P +
Sbjct: 378 EEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKD 437
Query: 333 DKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDE-DVQVEVAEK--VQKSSSPREMQK 389
+ + + E + + + Q+L + ++ E VEV E+ +K +P ++
Sbjct: 438 SLPKKRPIYED-----KKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP 492
Query: 390 AEEKEVPEDSLEECAITCSNSHGP-YDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDA 448
EE++ + L++ S+ + N+ H + K EE++ +
Sbjct: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEE------------- 539
Query: 449 VHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSS 508
E E ++ EEEE+ + EE+E + D G + P + ++S Y S
Sbjct: 540 ----EEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
Query: 509 TFHSLEEQQVCMAVDIGRHRWDQVKKE 535
+E++ A D + R ++ + E
Sbjct: 596 DDDRTKEER---AYDKAKRRIEKRRLE 619
Score = 35.0 bits (79), Expect = 0.27
Identities = 48/250 (19%), Positives = 97/250 (38%), Gaps = 24/250 (9%)
Query: 311 EGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSP-----ENDND 365
E D S+ + E + + + D+S + LQ R Q QK P + D
Sbjct: 166 EDEDNSKKIKERSRINSSGESGDESD-EFLQS------RKGQKKNQKNKPGPNIESGNED 218
Query: 366 DDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKI 425
DD +++ + + RE +K +E++ L+E + + RK
Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRK--- 275
Query: 426 TFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQES 485
FEE+ V S + + + + P ++D+ E +K + + +EE+ ++
Sbjct: 276 -FEEETVKSKVTVDTGVIPASEEKAETP-TAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK 333
Query: 486 WDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLS 545
+T+ E LA + EE+++ ++ R ++ + E ++
Sbjct: 334 KGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEK------- 386
Query: 546 RELLDEKEPE 555
RE +KE E
Sbjct: 387 RERKKQKEKE 396
Score = 32.3 bits (72), Expect = 1.8
Identities = 42/230 (18%), Positives = 99/230 (43%), Gaps = 10/230 (4%)
Query: 333 DKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEE 392
D + ++L+++ ++ + A+ V+ S +D+DD + + K QKS+ ++ +EE
Sbjct: 109 DDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSN--KKWDGSEE 166
Query: 393 KEVPEDSLEECAITCSNSHGPYDSNQ--PHRKTKITFEEDKVDSTLIGSSSHVEWEDAVH 450
E ++E + S+ +S++ RK + +++K + + + +
Sbjct: 167 DEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIK 226
Query: 451 IIPENESDDEEEEEK----GPVSPRNLQESEEEEV-PQESWDEGYSTLSIPPERLASYQS 505
+ + +++ +E E K R L+E EE E ++ + S E + S +
Sbjct: 227 TVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVT 286
Query: 506 Y-SSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEP 554
+ + EE+ + D+ KK+ ++ G + +E +K P
Sbjct: 287 VDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGP 336
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform
1 [Homo sapiens]
Length = 1722
Score = 53.9 bits (128), Expect = 6e-07
Identities = 87/422 (20%), Positives = 173/422 (40%), Gaps = 55/422 (13%)
Query: 90 ENDEDEDEDVQVEEDEKVLES-SAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQP 148
E D+ + VE E VL + + KA E + +D + ++CS +G +
Sbjct: 36 ETQSDDSDTDSVELPESVLHCINIIKNRSKAVEELILQDLEDTDILSCS--YGAVSNNHM 93
Query: 149 HKNIKITFEEDKVNSSLV-----VDRESSHDGCQDAL--NILPVPGPTSSATNVSMVVSA 201
H ++ E ++ + L+ +++E D + +P P P + ++
Sbjct: 94 HLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDD 153
Query: 202 GPLS------SEKAEMNI---------LEINEK--LCPQLAEKKQQFRSLKEK--CFVTQ 242
++ EK + LE EK L Q +++QF+ +EK C++ Q
Sbjct: 154 ADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQ 213
Query: 243 VACFLAKQQNKYKYEECKDLIKSMLRNERQFKEEKL-AEQLKQAEE-LRQYKVLVHSQER 300
K +N K E+ K N+ +KEEK+ E+ KQ EE +R + + +
Sbjct: 214 FKVEKKKLENIQKQEQDK-------MNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERT 266
Query: 301 ELTQLREK-----LREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLV 355
+EK L++ +A+ + +A + + G ++EQ+ R AQ
Sbjct: 267 RFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQK----YGPIIKEQIESKKRKAQEWK 322
Query: 356 QKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYD 415
+K + +++ ++E +++++ R+ QK EE++ E EE + +
Sbjct: 323 EKEAKIRQKEEENRKRLEEEQRIKEE---RKKQKEEERKRREKEYEE-----KKNIVKQE 374
Query: 416 SNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQE 475
Q K KI ED +I S+ + H+ E+ S+D+ + K V + ++
Sbjct: 375 REQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQ 434
Query: 476 SE 477
+
Sbjct: 435 ED 436
Score = 43.1 bits (100), Expect = 0.001
Identities = 76/403 (18%), Positives = 162/403 (40%), Gaps = 82/403 (20%)
Query: 12 QPTEEIQQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQE 71
Q EE ++K QE+E L L++ +A+ + +A + + G ++E
Sbjct: 260 QMEEERTRFK---DQQEKEKNSL---LKQQNNAAVKIQAKYKAFVAYQK----YGPIIKE 309
Query: 72 QLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEE 131
Q+ R AQ +K + ++E+ ++EE++++ E R+ QK EE K E EE
Sbjct: 310 QIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEE---RKKQKEEERKRREKEYEE 366
Query: 132 CAITCSNSHGPCDSIQPHKNIKITFEEDKVNSSLVVDRESSHDGCQDALNILPVPGPTSS 191
KNI E ++ ++ RE DA L +
Sbjct: 367 -----------------KKNIVKQEREQLISKEKIILRE-------DASQQLIISSALKK 402
Query: 192 ATNVSMVVSAGPLSSEKAEM--NILEINEKLCPQLAEKKQQFRSLKEKCFVTQVACFLAK 249
+ + +S +S++K ++ N+++ N KKQ+ V +L +
Sbjct: 403 SGYNNKHLSLEDISNDKGDIAKNLVDEN--------SKKQE-----------DVLLWLVE 443
Query: 250 QQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQ-------EREL 302
+ N + + + ++K + + KL E + L +K+ ++ EL
Sbjct: 444 ESNMKENVDRQTILKESI-------QVKLKESISSQTILADFKMEEKNENLAKKRCSEEL 496
Query: 303 TQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPE- 361
+ K + + N L+ L P + D Q++ ++ +H++ + + +
Sbjct: 497 VKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEE----KIMKHVINENTGQK 552
Query: 362 -----NDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDS 399
N + +V+ +K+ K + +++QK E++E+ E +
Sbjct: 553 TQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQN 595
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,410,054
Number of Sequences: 37866
Number of extensions: 1791009
Number of successful extensions: 19764
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 809
Number of HSP's that attempted gapping in prelim test: 11572
Number of HSP's gapped (non-prelim): 6001
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.