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Search of human proteins with 119703744
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119703744 desmoglein 1 preproprotein [Homo sapiens]
(1049 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119703744 desmoglein 1 preproprotein [Homo sapiens] 2113 0.0
gi|119964718 desmoglein 3 preproprotein [Homo sapiens] 719 0.0
gi|197313787 desmoglein 4 isoform 1 [Homo sapiens] 605 e-173
gi|29789445 desmoglein 4 isoform 2 [Homo sapiens] 605 e-173
gi|116534898 desmoglein 2 preproprotein [Homo sapiens] 548 e-155
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 277 4e-74
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 258 2e-68
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 253 7e-67
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 253 7e-67
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 249 1e-65
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 246 1e-64
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 244 4e-64
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 226 7e-59
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 218 3e-56
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 218 3e-56
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 212 1e-54
gi|29570800 cadherin-like 26 isoform a [Homo sapiens] 196 7e-50
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 193 6e-49
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 164 4e-40
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 163 7e-40
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 157 4e-38
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 154 5e-37
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 152 2e-36
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 150 8e-36
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 150 8e-36
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 145 2e-34
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 145 2e-34
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 144 4e-34
gi|221316595 cadherin 17 precursor [Homo sapiens] 139 1e-32
gi|221316593 cadherin 17 precursor [Homo sapiens] 139 1e-32
>gi|119703744 desmoglein 1 preproprotein [Homo sapiens]
Length = 1049
Score = 2113 bits (5476), Expect = 0.0
Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)
Query: 1 MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE 60
MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE
Sbjct: 1 MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE 60
Query: 61 GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT 120
GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT
Sbjct: 61 GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT 120
Query: 121 PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN 180
PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN
Sbjct: 121 PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN 180
Query: 181 ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS 240
ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS
Sbjct: 181 ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS 240
Query: 241 DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS 300
DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS
Sbjct: 241 DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS 300
Query: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS
Sbjct: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
Query: 361 IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTT 420
IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTT
Sbjct: 361 IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTT 420
Query: 421 VRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN 480
VRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN
Sbjct: 421 VRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN 480
Query: 481 INIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLL 540
INIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLL
Sbjct: 481 INIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLL 540
Query: 541 SDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE 600
SDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE
Sbjct: 541 SDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE 600
Query: 601 GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGV 660
GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGV
Sbjct: 601 GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGV 660
Query: 661 KTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLI 720
KTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLI
Sbjct: 661 KTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLI 720
Query: 721 YDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQST 780
YDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQST
Sbjct: 721 YDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQST 780
Query: 781 EPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES 840
EPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES
Sbjct: 781 EPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES 840
Query: 841 YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIA 900
YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIA
Sbjct: 841 YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIA 900
Query: 901 PSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAG 960
PSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAG
Sbjct: 901 PSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAG 960
Query: 961 VTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSD 1020
VTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSD
Sbjct: 961 VTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSD 1020
Query: 1021 HHFNQTIGSASPSTARSRITKYSTVQYSK 1049
HHFNQTIGSASPSTARSRITKYSTVQYSK
Sbjct: 1021 HHFNQTIGSASPSTARSRITKYSTVQYSK 1049
>gi|119964718 desmoglein 3 preproprotein [Homo sapiens]
Length = 999
Score = 719 bits (1856), Expect = 0.0
Identities = 430/1003 (42%), Positives = 581/1003 (57%), Gaps = 126/1003 (12%)
Query: 5 FFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDN 64
F R L IF+VV+ V+ E RI+ + + + RRQKREW+KFA CREGEDN
Sbjct: 5 FPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDN 64
Query: 65 SKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFI 124
SKRNPIAKI SD A Q++TYRISGVGIDQPP+GIFV+++ TG+INIT+IVDRE TP F+
Sbjct: 65 SKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFL 124
Query: 125 IYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDA 184
I CRALN+ G D+E+PL L V++LDINDNPPVFS F G+IEENS +N+LVMILNATDA
Sbjct: 125 ITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDA 184
Query: 185 DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDG 244
DEPN+LNSKIAFKI+ QEP+ +PMF+++RNTGE+RT+ N LDREQ Y L V G+D+DG
Sbjct: 185 DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDG 244
Query: 245 GADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWM 304
+G+S +CECNIK+ DVNDN P S Y+ I+EN L+S LL +V DLDEE++ NW+
Sbjct: 245 --EGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWL 302
Query: 305 AVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQ 364
AV FF SGNEGNWFEI+ + RTN GILKVVK LDYE +QS++LSI V+NKAEFH S++S+
Sbjct: 303 AVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISR 362
Query: 365 YKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKV----GDFVATDLDTGRPSTT 420
Y+++++ +++ V+NV EG FRP SKT+ V + S V G + A D DT + ++
Sbjct: 363 YRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASN 422
Query: 421 VRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN 480
V+YVMG N L +DS+T ++ + ++ ++ +L+ID+ +T TGT+
Sbjct: 423 VKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVY 482
Query: 481 INIQSFGNDDRT---------NTEPNTKITTNT--------------------------- 504
+ + F ++ T ++ P+ ++ T
Sbjct: 483 VRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSIT 542
Query: 505 ---------GRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDL---------------L 540
QE Y S TDS P + ++
Sbjct: 543 TLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTT 602
Query: 541 SDNVHFGPAGIGLL---IMGFLVLGLV-----PFLMICCDCGGAPRS--AAGFEPVPECS 590
S +G G L +G L+LGL+ P L++ CDCG GF PVP+ S
Sbjct: 603 SPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGS 662
Query: 591 DGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYG-GREMQDLGGGE 649
+G IH W +EG PE ++IT + +PP AN + +++S V TN Y G ++ G E
Sbjct: 663 EGTIHQWGIEGAHPEDKEITNIC--VPPVTANGADFMESSEVCTNTYARGTAVEGTSGME 720
Query: 650 RMTGF-ELTEGVKTSGMPE-----------------ICQE-YSGTLRR-----NSMRECR 685
T TE +G IC SGT+R + ++
Sbjct: 721 MTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYA 780
Query: 686 EGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEG---VGSPAGSVGCCSFIGED 742
+G ++MNF++SYF QKA+A A+ED+G+ +NDCLLIYD EG GSP GSVGCCSFI +D
Sbjct: 781 DGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADD 840
Query: 743 LDDSFLDTLGPKFKKLADISLGKESY------PDLDPSWPPQSTEPVCLPQETEPVVSGH 796
LDDSFLD+LGPKFKKLA+ISLG + P D + +S Q+T G
Sbjct: 841 LDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQT-----GF 895
Query: 797 PPISPHFGTTTVISESTYPS-GPGVLHPKPILDPLGYGNVTVTESYTTSDTL-KPSVHVH 854
G+ + ST S P V P DPL +GN VTE+Y+ S +L +PS
Sbjct: 896 VKCQTLSGSQGASALSTSGSVQPAVSIP----DPLQHGNYLVTETYSASGSLVQPSTAGF 951
Query: 855 DNRPASNVVVTERVVGPISGADLHGMLEMP-DLRDGSNVIVTE 896
D NV+VTERV+ PIS + G L P LR ++ TE
Sbjct: 952 DPLLTQNVIVTERVICPIS--SVPGNLAGPTQLRGSHTMLCTE 992
Score = 211 bits (538), Expect = 2e-54
Identities = 234/940 (24%), Positives = 386/940 (41%), Gaps = 158/940 (16%)
Query: 60 EGEDNSKRNPIAKIHSDCAANQ--QVTYRISGVGIDQPPYG--IFVINQKTGEIN-ITSI 114
E E+NS N + I + A++ + +I+ + Q P G +F++++ TGE+ +T+
Sbjct: 165 EIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNS 224
Query: 115 VDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANT 174
+DRE + + + G+ L E ++V D+NDN P+F + ++ +IEEN ++
Sbjct: 225 LDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSE 284
Query: 175 LVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGE-IRTMNNFLDREQYGQY 233
L+ TD DE N + + + T E I + LD EQ
Sbjct: 285 LLRF-QVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSV 343
Query: 234 ALAVRGSDRDGGADGMSAECECN-----IKILDVNDNIPYMEQSSYTIEIQENTLNSNLL 288
L++ ++ + + I++++V + I + +S T +Q+ + L+
Sbjct: 344 KLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAF-RPASKTFTVQKGISSKKLV 402
Query: 289 EI-----RVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQ 343
+ + ID D +A+ V + + N+G + I+ + +K VK ++ ++
Sbjct: 403 DYILGTYQAIDEDTNKAAS--NVKYVMGRNDGGYLMID----SKTAEIKFVKNMNRDSTF 456
Query: 344 SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK 403
+ +I A + +Y K S +V V P F T V+ + +
Sbjct: 457 IVNKTITAEVLA------IDEYTGKTSTGTVYV----RVPDFNDNCPTAVLEKDAVCSSS 506
Query: 404 VGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGT 463
V+ R + + + + P L AV S T L + + + Q + G Y +
Sbjct: 507 PSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSIT-TLNATSALLRAQEQIPPGVYHIS 565
Query: 464 ILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTD 523
++ D R C ++ ++ D+R T+Y T++ T
Sbjct: 566 LVLTDSQNNR-CEMPRSLTLEVCQCDNR-----------------GICGTSYPTTSPGTR 607
Query: 524 SSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAA-- 581
+ +S GPA IGLL++G L+L L P L++ CDCG
Sbjct: 608 YGRPHSGR--------------LGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTG 653
Query: 582 GFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYG-GR 640
GF PVP+ S+G IH W +EG PE ++IT + +PP AN + +++S V TN Y G
Sbjct: 654 GFIPVPDGSEGTIHQWGIEGAHPEDKEITNIC--VPPVTANGADFMESSEVCTNTYARGT 711
Query: 641 EMQDLGGGERMTGF-ELTEGVKTSGMPE-----------------ICQE-YSGTLRRN-- 679
++ G E T TE +G IC SGT+R
Sbjct: 712 AVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHS 771
Query: 680 ---SMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGV---GSPAGSV 733
+ ++ +G ++MNF++SYF QKA+A A+ED+G+ +NDCLLIYD EG GSP GSV
Sbjct: 772 TGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSV 831
Query: 734 GCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVV 793
GCCSFI + DLD S+
Sbjct: 832 GCCSFIAD----------------------------DLDDSFLDS--------------- 848
Query: 794 SGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHV 853
+ P F IS G V P GYG + T
Sbjct: 849 -----LGPKFKKLAEISLGVDGEGKEVQPPSK---DSGYGIESCGHPIEVQQTGFVKCQT 900
Query: 854 HDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHH 913
++ + T V P + +PD N +VTE A S + S
Sbjct: 901 LSGSQGASALSTSGSVQPA--------VSIPDPLQHGNYLVTETYSASGSLVQPSTAGFD 952
Query: 914 PRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTE 953
P + NV+VTERVI P S + G+L+ +L +H ++ TE
Sbjct: 953 PLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTE 992
>gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
Length = 1059
Score = 605 bits (1560), Expect = e-173
Identities = 291/503 (57%), Positives = 385/503 (76%), Gaps = 5/503 (0%)
Query: 1 MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE 60
MDW FFR + +L I +VV+EVNSEF ++V++++ +NGT KW ++RRQKREWIKFAAACRE
Sbjct: 1 MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
Query: 61 GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT 120
GEDNSKRNPIAKI SDC +NQ++TYRISGVGID+PPYG+F IN +TGEINITS+VDRE+T
Sbjct: 61 GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
Query: 121 PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN 180
P F+IYCRALNS G+DLERPLELRV+V+DINDN PVFS + + IEENS+ANTLV+ L
Sbjct: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
Query: 181 ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS 240
ATDADE N+LNSKIA+KI+ QEPS +PMFI+NR TGE+ TM++FLDREQ+ Y L VRGS
Sbjct: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
Query: 241 DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS 300
DRDG ADG+S+EC+C IK+LDVNDN P +E++SY+ I+EN L+S L+ ++ IDLDEE +
Sbjct: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
Query: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
NW+A +SGN+GNWF+I+ + +TN GILKVVK LDYE ++QLSIGV+N+A+FH+S
Sbjct: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
Query: 361 IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVV-TGNMGS---NDKVGDFVATDLDTGR 416
+ SQ+++ + + + V++V EGP F P + + V G GS N +G + A DLDTG
Sbjct: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
Query: 417 PSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCT 476
P+T VRY++G++ L +DSRTG++ + K+ ++ G Y IL+IDD +T T
Sbjct: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
Query: 477 GTININIQSFGNDDRTNTEPNTK 499
GTI I + ND N P +
Sbjct: 481 GTICIEVPDI-NDYCPNIFPERR 502
Score = 257 bits (657), Expect = 4e-68
Identities = 278/1023 (27%), Positives = 441/1023 (43%), Gaps = 208/1023 (20%)
Query: 80 NQQVTYRISGVGIDQPPYG--IFVINQKTGEI-NITSIVDREVTPFFIIYCRALNSMG-- 134
N ++ Y+I + Q P G +F++N+ TGE+ ++S +DRE + + R + G
Sbjct: 191 NSKIAYKI----VSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAA 246
Query: 135 QDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKI 194
L + R++VLD+NDN P +++ IEEN ++ L+ L A D DE N
Sbjct: 247 DGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIR-LQAIDLDEEGTDNWLA 305
Query: 195 AFKIIRQEPSDSPMFIINR----NTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMS 250
+ I+ +D F I N G ++ + LD EQ L++ ++ ++
Sbjct: 306 QYLIL--SGNDGNWFDIQTDPQTNEGILKVVK-MLDYEQAPNIQLSIGVKNQADFHYSVA 362
Query: 251 AECECN-----IKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEI-----RVIDLDEEFS 300
++ + + I+++DV + P S+ ++E S+LL IDLD
Sbjct: 363 SQFQMHPTPVRIQVVDVREG-PAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNP 421
Query: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
A V + I + G+W ++++ RT G ++ + D ++ + G+ AE
Sbjct: 422 AT--DVRYIIGHDAGSW--LKIDSRT--GEIQFSREFDKKSKYIIN---GIYT-AEILAI 471
Query: 361 IMSQYKLKASAISVTVLNVIEG-PVFRPGSKTYVVTGNMGSNDKVGDFVATDLDT-GRPS 418
K I + V ++ + P P +T + D ++ + + G P
Sbjct: 472 DDGSGKTATGTICIEVPDINDYCPNIFPERRTICI-------DSPSVLISVNEHSYGSPF 524
Query: 419 TTVRYVMGNNPA-----DLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQR 473
T V+ P D+ + ++ + LT K ++ G Y+ IL + D+ R
Sbjct: 525 TFC--VVDEPPGIADMWDVRSTNATSAILTAKQVLSP-------GFYEIPIL-VKDSYNR 574
Query: 474 TCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPG 533
C + + + DD N +S ++ Y T V + G
Sbjct: 575 ACELAQMVQLYACDCDD------------NHMCLDSGAAGIYTEDITGDTYGPVTEDQAG 622
Query: 534 NGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAG--FEPVPECSD 591
NV GPAGIG++++G L+L L P L++ C C G F PVPE +
Sbjct: 623 -------VSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGE 675
Query: 592 GAIHSWAVEGPQPEPRDITT-VIP----------------QIPPDNANIIECIDNSGVYT 634
G + SW +EG PE R + +P + A + + S +YT
Sbjct: 676 GVMQSWRIEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYT 735
Query: 635 NEY--GGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNS-----MRECREG 687
N Y GG + G E TG G+ +G SG R+ S +R+ +
Sbjct: 736 NTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGA----SGAARKRSSTMGTLRDYADA 791
Query: 688 GLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSF 747
+NM F++SYF +KAYAYADEDEGRP+NDCLLIYD EGVGSP GS+GCCS+I +DLD+S
Sbjct: 792 DINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESC 851
Query: 748 LDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTT 807
++TL PKF+ LA+I L E P +P + C+P T+
Sbjct: 852 METLDPKFRTLAEICLNTEIEP-----FP---SHQACIPISTD----------------- 886
Query: 808 VISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPS-VHVHDNRPASNVVVTE 866
P+L P N V ES L PS V + AS VV
Sbjct: 887 ----------------LPLLGP----NYFVNES----SGLTPSEVEFQEEMAASEPVV-- 920
Query: 867 RVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERV 926
HG ++IVTE + + I P+ + NVVVTE V
Sbjct: 921 -----------HG-----------DIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAV 958
Query: 927 IQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGA 986
+ P + G++ + ELA+ +NVI ERV++ GV +S ++ G +G
Sbjct: 959 MAPVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGP---------- 1008
Query: 987 GSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQ 1046
+SG + G I + + S D QT+GS SP T+R R+T+YS +
Sbjct: 1009 ---VMSGNILVGPEIQVMQM----------MSPDLPIGQTVGSTSPMTSRHRVTRYSNIH 1055
Query: 1047 YSK 1049
Y++
Sbjct: 1056 YTQ 1058
>gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
Length = 1040
Score = 605 bits (1560), Expect = e-173
Identities = 291/503 (57%), Positives = 385/503 (76%), Gaps = 5/503 (0%)
Query: 1 MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACRE 60
MDW FFR + +L I +VV+EVNSEF ++V++++ +NGT KW ++RRQKREWIKFAAACRE
Sbjct: 1 MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE 60
Query: 61 GEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT 120
GEDNSKRNPIAKI SDC +NQ++TYRISGVGID+PPYG+F IN +TGEINITS+VDRE+T
Sbjct: 61 GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT 120
Query: 121 PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN 180
P F+IYCRALNS G+DLERPLELRV+V+DINDN PVFS + + IEENS+ANTLV+ L
Sbjct: 121 PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC 180
Query: 181 ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS 240
ATDADE N+LNSKIA+KI+ QEPS +PMFI+NR TGE+ TM++FLDREQ+ Y L VRGS
Sbjct: 181 ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS 240
Query: 241 DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFS 300
DRDG ADG+S+EC+C IK+LDVNDN P +E++SY+ I+EN L+S L+ ++ IDLDEE +
Sbjct: 241 DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT 300
Query: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
NW+A +SGN+GNWF+I+ + +TN GILKVVK LDYE ++QLSIGV+N+A+FH+S
Sbjct: 301 DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS 360
Query: 361 IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVV-TGNMGS---NDKVGDFVATDLDTGR 416
+ SQ+++ + + + V++V EGP F P + + V G GS N +G + A DLDTG
Sbjct: 361 VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN 420
Query: 417 PSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCT 476
P+T VRY++G++ L +DSRTG++ + K+ ++ G Y IL+IDD +T T
Sbjct: 421 PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT 480
Query: 477 GTININIQSFGNDDRTNTEPNTK 499
GTI I + ND N P +
Sbjct: 481 GTICIEVPDI-NDYCPNIFPERR 502
Score = 278 bits (712), Expect = 1e-74
Identities = 280/1006 (27%), Positives = 445/1006 (44%), Gaps = 193/1006 (19%)
Query: 80 NQQVTYRISGVGIDQPPYG--IFVINQKTGEI-NITSIVDREVTPFFIIYCRALNSMG-- 134
N ++ Y+I + Q P G +F++N+ TGE+ ++S +DRE + + R + G
Sbjct: 191 NSKIAYKI----VSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAA 246
Query: 135 QDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKI 194
L + R++VLD+NDN P +++ IEEN ++ L+ L A D DE N
Sbjct: 247 DGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIR-LQAIDLDEEGTDNWLA 305
Query: 195 AFKIIRQEPSDSPMFIINR----NTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMS 250
+ I+ +D F I N G ++ + LD EQ L++ ++ ++
Sbjct: 306 QYLIL--SGNDGNWFDIQTDPQTNEGILKVVK-MLDYEQAPNIQLSIGVKNQADFHYSVA 362
Query: 251 AECECN-----IKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEI-----RVIDLDEEFS 300
++ + + I+++DV + P S+ ++E S+LL IDLD
Sbjct: 363 SQFQMHPTPVRIQVVDVREG-PAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNP 421
Query: 301 ANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS 360
A V + I + G+W ++++ RT G ++ + D ++ + G+ AE
Sbjct: 422 AT--DVRYIIGHDAGSW--LKIDSRT--GEIQFSREFDKKSKYIIN---GIYT-AEILAI 471
Query: 361 IMSQYKLKASAISVTVLNVIEG-PVFRPGSKTYVVTGNMGSNDKVGDFVATDLDT-GRPS 418
K I + V ++ + P P +T + D ++ + + G P
Sbjct: 472 DDGSGKTATGTICIEVPDINDYCPNIFPERRTICI-------DSPSVLISVNEHSYGSPF 524
Query: 419 TTVRYVMGNNPA-----DLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQR 473
T V+ P D+ + ++ + LT K ++ G Y+ IL + D+ R
Sbjct: 525 TFC--VVDEPPGIADMWDVRSTNATSAILTAKQVLSP-------GFYEIPIL-VKDSYNR 574
Query: 474 TCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPG 533
C + + + DD N +S ++ Y T V + G
Sbjct: 575 ACELAQMVQLYACDCDD------------NHMCLDSGAAGIYTEDITGDTYGPVTEDQAG 622
Query: 534 NGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAG--FEPVPECSD 591
NV GPAGIG++++G L+L L P L++ C C G F PVPE +
Sbjct: 623 -------VSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGE 675
Query: 592 GAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEY--GGREMQDLGGGE 649
G + SW +EG PE RD++ + P +N + +D+S +YTN Y GG + G E
Sbjct: 676 GVMQSWRIEGAHPEDRDVSNICA--PMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVE 733
Query: 650 RMTGFELTEGVKTSGMPEICQEYSGTLRRNS-----MRECREGGLNMNFMESYFCQKAYA 704
TG G+ +G SG R+ S +R+ + +NM F++SYF +KAYA
Sbjct: 734 LNTGMGTAVGLMAAGAAGA----SGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYA 789
Query: 705 YADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLG 764
YADEDEGRP+NDCLLIYD EGVGSP GS+GCCS+I +DLD+S ++TL PKF+ LA+I L
Sbjct: 790 YADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLN 849
Query: 765 KESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPK 824
E P +P + C+P T+
Sbjct: 850 TEIEP-----FP---SHQACIPISTD---------------------------------L 868
Query: 825 PILDPLGYGNVTVTESYTTSDTLKPS-VHVHDNRPASNVVVTERVVGPISGADLHGMLEM 883
P+L P N V ES L PS V + AS VV HG
Sbjct: 869 PLLGP----NYFVNES----SGLTPSEVEFQEEMAASEPVV-------------HG---- 903
Query: 884 PDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPEL 943
++IVTE + + I P+ + NVVVTE V+ P + G++ + EL
Sbjct: 904 -------DIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAEL 956
Query: 944 ANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGL 1003
A+ +NVI ERV++ GV +S ++ G +G +SG + G I +
Sbjct: 957 ADYNNVIYAERVLASPGVPDMSNSSTTEGCMGP-------------VMSGNILVGPEIQV 1003
Query: 1004 SSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK 1049
+ S D QT+GS SP T+R R+T+YS + Y++
Sbjct: 1004 MQM----------MSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQ 1039
>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
Length = 1118
Score = 548 bits (1412), Expect = e-155
Identities = 409/1165 (35%), Positives = 579/1165 (49%), Gaps = 187/1165 (16%)
Query: 12 LFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHS-IRRQKREWIKFAAACREGEDNSKRNPI 70
L + L+ V S +QV +N + H + RQKR WI A REGED SK+NPI
Sbjct: 11 LLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPI 70
Query: 71 AKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCR 128
AKIHSD A + ++TY+ +G GI +PP+GIFV N+ TGE+N+TSI+DRE TPFF++
Sbjct: 71 AKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGY 130
Query: 129 ALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPN 188
AL++ G ++E+PLELR++VLDINDN PVF+ F G +EE S A+TLVM +NATDADEPN
Sbjct: 131 ALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPN 190
Query: 189 NLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGG-AD 247
LNSKI+++I+ EP+ P+F +N++TGEI T + LDRE++ Y L V D +G D
Sbjct: 191 TLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTD 250
Query: 248 GMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVI 307
+ + I+ILDVNDNIP +E ++EN +N + I+V D DE S NW+A
Sbjct: 251 KPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANF 310
Query: 308 FFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKL 367
F SGNEG +F IE + +TN GI+ ++K +DYE M++L S+ V NKA FH SI S+YK
Sbjct: 311 TFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKP 370
Query: 368 KASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK---VGDFVATDLDTGRPSTTVRYV 424
I V V NV EG F+ + V+ +M + K +G+F A D DTG P+ RYV
Sbjct: 371 TPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPA-HARYV 429
Query: 425 MGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSI-DDNLQRTCTGTININI 483
+ + ++VDS T ++ L E + G Y I++I +D ++T TGT+ IN+
Sbjct: 430 KLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINV 489
Query: 484 QSFGNDDRTNTEPNTKIT----------------TNTG--------------------RQ 507
+ ++ T EP I N+G RQ
Sbjct: 490 EDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQ 549
Query: 508 ESTSSTNY----------------DTSTTSTDSSQVYSSE-----PGNGAKDLLSDN-VH 545
ESTS D S QV + G+G ++ D+ V
Sbjct: 550 ESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVG 609
Query: 546 FGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPE 605
GPA I L+I+ FL+L LVP L++ C CG + A GF P+P + +H W EG PE
Sbjct: 610 LGPAAIALMILAFLLLLLVPLLLLMCHCG---KGAKGFTPIPGTIE-MLHPWNNEGAPPE 665
Query: 606 PRDITTVIPQ-IPPDNANIIECIDNSGVYTNE------------YGGREMQDLGG----- 647
+ V+P +P D + + G E G EM ++ G
Sbjct: 666 DK----VVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEH 721
Query: 648 ----GERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAY 703
R T F G + +G R + + LN F+ +YF KA
Sbjct: 722 RSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAA 781
Query: 704 AYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISL 763
+Y +EDE + DCLL+Y E S S+GCCSFI +LDD FLD LG KFK LA++ L
Sbjct: 782 SYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCL 841
Query: 764 GKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPH--FGTTTVISESTYPSGPGVL 821
G++ D++ + Q +P + H T V SE+TY SG
Sbjct: 842 GQKI--DINKE----------IEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFP 889
Query: 822 HPK------------------------------PILDPLGYGNVTVTE-SYTTSDTLKPS 850
PK P+ DP+ NV TE SY T T+ P+
Sbjct: 890 VPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPT 949
Query: 851 VHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLT 910
+ +++VTERV P S +++ P +G+ V+VTERVI P L
Sbjct: 950 TVILGPSQPQSLIVTERVYAPAS-----TLVDQPYANEGT-VVVTERVIQPHGGGSNPLE 1003
Query: 911 -IHHPRESSNVVVTER--VIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGT 967
H ++ V+V ER + P+SG+ +L+M P +A NV VTERV++ A
Sbjct: 1004 GTQHLQDVPYVMVRERESFLAPSSGVQPTLAM-PNIAVGQNVTVTERVLAPAST------ 1056
Query: 968 TGISGGIGSSGLVGT--SMGAGSGALSGAGISG--GGIGLSSLGGTASIGHMRSSSDHHF 1023
+ SS + T SM A + +SGAG+ G GL G H
Sbjct: 1057 ------LQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESG--------------HS 1096
Query: 1024 NQTIGSASPSTARSRITKYSTVQYS 1048
N TI +T+ +R+TK+STVQ+S
Sbjct: 1097 NSTI-----TTSSTRVTKHSTVQHS 1116
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 277 bits (708), Expect = 4e-74
Identities = 220/774 (28%), Positives = 344/774 (44%), Gaps = 64/774 (8%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
+RR KR W + E + ++ SD A N + Y I G G+DQ P +F +
Sbjct: 130 LRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVE 189
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
+ TG + T VDRE F I A G E PL L +++ D NDN P+F+ T+
Sbjct: 190 RDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYT 249
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNN 223
I EN T V + ATD DEP+ +++++ + II Q P +F ++ TG I T ++
Sbjct: 250 FTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSS 309
Query: 224 FLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTL 283
LDRE +Y L ++ D DG G+ C I I DVND++P ++SY ++ENT+
Sbjct: 310 QLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTV 369
Query: 284 NSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQ 343
+ +L + V D D +ANW A + GNE F+I + +TN G+L VVKPL+YE Q
Sbjct: 370 DVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQ 429
Query: 344 SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK 403
+ L IGV N+A F + + + ++V V + EGP P +T + N
Sbjct: 430 QMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTT 489
Query: 404 VGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGT 463
+ A D +T R S+ +RY +P + +D TG + + + +E + G Y T
Sbjct: 490 SNGYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNIT 548
Query: 464 ILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTN----------TGRQESTSST 513
+L+ D RTCTGT+ I +Q ND+ T I E
Sbjct: 549 VLASDQG-GRTCTGTLGIILQDV-NDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGP 606
Query: 514 NYDTSTTSTDS--SQVYSSEPGNGAKDLLS--DNVHFGPAGIGLLIMGFLVLGLVPFL-M 568
+D S S+ S +++ + N LS ++ FG + + + L + V L +
Sbjct: 607 PFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDV 666
Query: 569 ICCDCGGAPRSAAGFEPVPECSDGAIH--SWAV---------------------EGPQPE 605
CDC + P G + WA+ G +
Sbjct: 667 TLCDC--ITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQ 724
Query: 606 PRDITTVIPQ----IPPDNANIIECIDNSGVYTNEYGGREMQ----DLGGGERMTGFELT 657
P+ I + Q + A + + ++ +T + G Q +G G + G E
Sbjct: 725 PKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETI 784
Query: 658 EGVKTSGMPEICQEYSGTLRRNSMRECREGGLNM-----------NFMESYFCQKAYAYA 706
E VK G + + G +++ CR G + +F + +K Y
Sbjct: 785 EMVK--GGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCN 842
Query: 707 DEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLAD 760
++ + + D +L Y+ EG GS AGSVGCCS E+ FLD L PKF+ LA+
Sbjct: 843 QDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAE 896
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 258 bits (659), Expect = 2e-68
Identities = 217/758 (28%), Positives = 345/758 (45%), Gaps = 61/758 (8%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
+RRQKR+W+ +C E E + +I S+ +V Y I+G G D PP G+F+I
Sbjct: 149 LRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIE 208
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
++TG + +T +DRE + ++ A++S G +E P+E+ + V D NDN P F+ F
Sbjct: 209 RETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFK 268
Query: 164 GQIEENSNANTLVMILNATDADEP-NNLNSKIAFKIIRQEPS--DSPMFIINRNTGEIRT 220
G + E + T VM + ATDAD+ N N+ IA+ I+ Q+P D MF INRNTG I
Sbjct: 269 GSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISV 328
Query: 221 MNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
+ LDRE + Y L V+ +D G +G+S I + D NDN P ++Y ++ E
Sbjct: 329 VTTGLDRESFPTYTLVVQAADLQG--EGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPE 386
Query: 281 NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
N N + ++V D D + W AV + I ++G F + N N GILK K LD+E
Sbjct: 387 NEANVVITTLKVTDADAPNTPAWEAV-YTILNDDGGQFVVTTNPVNNDGILKTAKGLDFE 445
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS 400
A Q L + V N F S+ + + ++V VL+V E P+F P K V+ + G
Sbjct: 446 AKQQYILHVAVTNVVPFEVSLTT----STATVTVDVLDVNEAPIFVPPEKRVEVSEDFGV 501
Query: 401 NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKY 460
++ + A + DT + Y + + A+ L ++ TG ++ + ++ +E + +
Sbjct: 502 GQEITSYTAQEPDTFM-EQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNST 560
Query: 461 QGTILSIDDNLQRTCTGT-ININIQSFGNDDRTNTEPNTKI---------TTNTGRQEST 510
++ DN TGT + I S ND+ EP T N +
Sbjct: 561 YTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLP 620
Query: 511 SSTNYDTSTTSTDSSQVYSSEPGNGAKDLL----SDNVHFGPAGIGLLIMGFLVLGLVPF 566
+T+ T+ + +S ++ + + ++ + + G I L +M V
Sbjct: 621 PNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTT 680
Query: 567 LMI-CCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVI------------ 613
L + CDC GA +PV + + A+ G + +I
Sbjct: 681 LEVSVCDCEGAAGVCRKAQPV----EAGLQIPAILGILGGILALLILILLLLLFLRRRAV 736
Query: 614 ---PQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQ 670
P +PP++ + DN Y E GG E QD + G + V + +
Sbjct: 737 VKEPLLPPED----DTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLM 792
Query: 671 EYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPA 730
L R + + E G NF++ KA AD D P D LL++D EG GS A
Sbjct: 793 SVPRYLPRPANPD--EIG---NFIDENL--KA---ADTDPTAPPYDSLLVFDYEGSGSEA 842
Query: 731 GSVGC--CSFIGEDLDDSFLDTLGPKFKKLADISLGKE 766
S+ S +D D +L+ G +FKKLAD+ G E
Sbjct: 843 ASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGE 880
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 253 bits (646), Expect = 7e-67
Identities = 144/446 (32%), Positives = 235/446 (52%), Gaps = 2/446 (0%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
+RR KR W + +E + ++ SD A N V Y ISG G+D+ P +F I
Sbjct: 130 LRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIE 189
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
+ TG + T VDRE F + A + G + PL L +RV D NDN PVF+ A +
Sbjct: 190 RDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNN 223
++ E+S T V ++ ATD DEP+ +++++ + I++Q P +F ++ +TG I T+++
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSH 309
Query: 224 FLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTL 283
+LDRE +Y+L ++ D DG G+ C I + D NDN P Q++Y ++EN
Sbjct: 310 YLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAF 369
Query: 284 NSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQ 343
N +L I + D D +ANW + GNE F+I ++ TN G+L VVKPL+YE +
Sbjct: 370 NVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENR 429
Query: 344 SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK 403
+ L IGV N+A F I L + ++V V ++ EGP P ++ + N+ K
Sbjct: 430 QVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSK 489
Query: 404 VGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGT 463
+ + A D + R +RY ++P + +D +G + + +E Y T
Sbjct: 490 INGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNIT 548
Query: 464 ILSIDDNLQRTCTGTININIQSFGND 489
+L+ID + R+CTGT+ +NI+ ++
Sbjct: 549 VLAIDKD-DRSCTGTLAVNIEDVNDN 573
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/166 (24%), Positives = 69/166 (41%), Gaps = 14/166 (8%)
Query: 96 PYGIFVINQKTGEINITSIVDREV-TPFFIIYCRALNSMGQDLERPLE--LRVRVLDIND 152
P G I++ +G I + I+DREV TP +Y + ++ +D +R L V + D+ND
Sbjct: 514 PKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKD-DRSCTGTLAVNIEDVND 572
Query: 153 NPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIIN 212
NPP + + L A D DEP + + F + P S ++ +
Sbjct: 573 NPPEILQEYVVICKPKMGYTDIL-----AVDPDEPVH-GAPFYFSLPNTSPEISRLWSLT 626
Query: 213 RNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAE---CEC 255
+ + ++ + +Y + + DR G A CEC
Sbjct: 627 K-VNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCEC 671
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 253 bits (646), Expect = 7e-67
Identities = 144/446 (32%), Positives = 235/446 (52%), Gaps = 2/446 (0%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
+RR KR W + +E + ++ SD A N V Y ISG G+D+ P +F I
Sbjct: 130 LRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIE 189
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
+ TG + T VDRE F + A + G + PL L +RV D NDN PVF+ A +
Sbjct: 190 RDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNN 223
++ E+S T V ++ ATD DEP+ +++++ + I++Q P +F ++ +TG I T+++
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSH 309
Query: 224 FLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTL 283
+LDRE +Y+L ++ D DG G+ C I + D NDN P Q++Y ++EN
Sbjct: 310 YLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAF 369
Query: 284 NSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQ 343
N +L I + D D +ANW + GNE F+I ++ TN G+L VVKPL+YE +
Sbjct: 370 NVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENR 429
Query: 344 SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK 403
+ L IGV N+A F I L + ++V V ++ EGP P ++ + N+ K
Sbjct: 430 QVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSK 489
Query: 404 VGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGT 463
+ + A D + R +RY ++P + +D +G + + +E Y T
Sbjct: 490 INGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNIT 548
Query: 464 ILSIDDNLQRTCTGTININIQSFGND 489
+L+ID + R+CTGT+ +NI+ ++
Sbjct: 549 VLAIDKD-DRSCTGTLAVNIEDVNDN 573
Score = 58.2 bits (139), Expect = 4e-08
Identities = 40/127 (31%), Positives = 60/127 (47%), Gaps = 13/127 (10%)
Query: 645 LGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMN-----------F 693
+G G + G E E +K G + + G +++ CR G ++ F
Sbjct: 767 MGSGMKNGGQETIEMMK--GGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSF 824
Query: 694 MESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGP 753
+ +K + ++ PS D +L Y+ EG GSPAGSVGCCS E+ FL+ L P
Sbjct: 825 TQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEP 884
Query: 754 KFKKLAD 760
KF LA+
Sbjct: 885 KFITLAE 891
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/166 (24%), Positives = 69/166 (41%), Gaps = 14/166 (8%)
Query: 96 PYGIFVINQKTGEINITSIVDREV-TPFFIIYCRALNSMGQDLERPLE--LRVRVLDIND 152
P G I++ +G I + I+DREV TP +Y + ++ +D +R L V + D+ND
Sbjct: 514 PKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKD-DRSCTGTLAVNIEDVND 572
Query: 153 NPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIIN 212
NPP + + L A D DEP + + F + P S ++ +
Sbjct: 573 NPPEILQEYVVICKPKMGYTDIL-----AVDPDEPVH-GAPFYFSLPNTSPEISRLWSLT 626
Query: 213 RNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAE---CEC 255
+ + ++ + +Y + + DR G A CEC
Sbjct: 627 K-VNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCEC 671
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 249 bits (636), Expect = 1e-65
Identities = 205/771 (26%), Positives = 335/771 (43%), Gaps = 64/771 (8%)
Query: 42 HSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFV 101
+ +RR+KR+W+ E + +I SD + + Y I+GVG DQPP +F
Sbjct: 162 NGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFS 221
Query: 102 INQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMAT 161
I+ +G + +T +DRE + + A++ G +E P++L + V+D+NDN P F
Sbjct: 222 IDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQV 281
Query: 162 FAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPS--DSPMFIINRNTGEIR 219
+ G ++E S T VM + A DAD+ N + ++I+ Q P MF IN TG+I
Sbjct: 282 YNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIV 341
Query: 220 TMNNFLDREQYGQYALAVRGSDRDGGAD-GMSAECECNIKILDVNDNIPYMEQSSYTIEI 278
T+ LDRE+ QY + V+ +D +G + G+S I + DVNDN P S++ E+
Sbjct: 342 TVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEV 401
Query: 279 QENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLD 338
EN + + + + V+D D+ S NW AV ISG+ F + + TN G++ VVK +D
Sbjct: 402 PENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVD 461
Query: 339 YEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNM 398
YE ++ L++ V N+A I ++ + ++++++++ E P F K + +
Sbjct: 462 YELNRAFMLTVMVSNQAPLASGIQMSFQ-STAGVTISIMDINEAPYFPSNHKLIRLEEGV 520
Query: 399 GSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGG 458
+ F A D D VRY ++PA L +++ G++T + +E
Sbjct: 521 PPGTVLTTFSAVDPDRFM-QQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNN 579
Query: 459 KYQGTILSIDDNL-QRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDT 517
Y+ T L+ D+ + + TGT+ I + ND+ P + + T D
Sbjct: 580 VYEATFLAADNGIPPASGTGTLQIYLIDI-NDNAPELLPKEAQICEKPNLNAINITAADA 638
Query: 518 STTSTDSSQVYSSE--PGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGG 575
V+ P K+ ++ A + L I+ +L G+ +I D G
Sbjct: 639 DVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRIL-YLEAGMYDVPIIVTDSGN 697
Query: 576 APRSAAGFEPVPEC-------------------SDGAIHS--------------WAVEGP 602
P S V C GAI + + +
Sbjct: 698 PPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMK 757
Query: 603 QPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKT 662
+ E T + P D+ DN Y E GG E QD ++L++ +
Sbjct: 758 RREKERHTKQLLIDPEDDVR-----DNILKYDEEGGGEEDQD---------YDLSQLQQP 803
Query: 663 SGMPEICQEYSGTLRRNSMRECREGGLNMNFMESY------FCQKAYAYADEDEGRPSND 716
M + + G R + E + M + F + AD D P D
Sbjct: 804 EAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYD 863
Query: 717 CLLIYDIEGVGSPAGSVGCC-SFIGEDLDDSFLDTLGPKFKKLADISLGKE 766
LL++D EG GS AGSV S D D +L+ GP+FKKLAD+ G E
Sbjct: 864 SLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGE 914
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 246 bits (627), Expect = 1e-64
Identities = 148/446 (33%), Positives = 227/446 (50%), Gaps = 2/446 (0%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
+RR KR W + E + ++ SD A N + Y I G G+DQ P +F +
Sbjct: 130 LRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVE 189
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
+ TG + T VDRE F I A G E PL L +++ D NDN P+F+ T+
Sbjct: 190 RDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYT 249
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNN 223
I EN T V + ATD DEP+ +++++ + II Q P +F ++ TG I T ++
Sbjct: 250 FTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSS 309
Query: 224 FLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTL 283
LDRE +Y L ++ D DG G+ C I I DVND++P ++SY ++ENT+
Sbjct: 310 QLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTV 369
Query: 284 NSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQ 343
+ +L + V D D +ANW A + GNE F+I + +TN G+L VVKPL+YE Q
Sbjct: 370 DVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQ 429
Query: 344 SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDK 403
+ L IGV N+A F + + + ++V V + EGP P +T + N
Sbjct: 430 QMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTT 489
Query: 404 VGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGT 463
+ A D +T R S+ +RY +P + +D TG + + + +E + G Y T
Sbjct: 490 SNGYKAYDPET-RSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNIT 548
Query: 464 ILSIDDNLQRTCTGTININIQSFGND 489
+L+ D RTCTGT+ I +Q ++
Sbjct: 549 VLASDQG-GRTCTGTLGIILQDVNDN 573
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 244 bits (622), Expect = 4e-64
Identities = 205/757 (27%), Positives = 335/757 (44%), Gaps = 49/757 (6%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
++RQKR+W+ E + +I SD N + Y ++G G DQPP GIF+IN
Sbjct: 154 LQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIIN 213
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
+G++++T +DRE F + A++ G +E P+++ + V+D+NDN P F +
Sbjct: 214 PISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWN 273
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPS-DSP-MFIINRNTGEIRTM 221
G + E S T VM + A DAD+PN LN + ++I+ Q PS SP MF IN TG+I T+
Sbjct: 274 GTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITV 333
Query: 222 NNFLDREQYGQYALAVRGSDRDGGAD-GMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
LDRE+ QY L ++ +D +G G+S I + DVNDN P ++ E+ E
Sbjct: 334 AAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPE 393
Query: 281 NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
N ++ + + V D D+ + W AV G+ F I+ + +N G++ VVKP+D+E
Sbjct: 394 NRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFE 453
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS 400
+ L++ N+ I + A+ +SVTV++V E P F P K + +
Sbjct: 454 TNRMFVLTVAAENQVPLAKGIQHPPQSTAT-VSVTVIDVNENPYFAPNPKIIRQEEGLHA 512
Query: 401 NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKY 460
+ F A D D +RY ++PA+ L +D G++T + +E N+ Y
Sbjct: 513 GTMLTTFTAQDPDR-YMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIY 571
Query: 461 QGTILSIDDNL-QRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSST--NYDT 517
T L+ D+ + + TGT+ I + ND+ P T T S + T +YD
Sbjct: 572 NATFLASDNGIPPMSGTGTLQIYLLDI-NDNAPQVLPQEAETCETPDPNSINITALDYDI 630
Query: 518 STTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAP 577
+ + P ++ ++ A + L I FL G+ +I D G P
Sbjct: 631 DPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIK-FLEAGIYEVPIIITDSGNPP 689
Query: 578 RSAAGFEPVPECS----------DGAIHSWAVEGP--------------------QPEPR 607
+S V C D + + G + R
Sbjct: 690 KSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRR 749
Query: 608 DITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGE-RMTGFELTEGVKTSGMP 666
D Q+ D + + DN Y E GG E QD + + + +K G+
Sbjct: 750 DKERQAKQLLIDPEDDVR--DNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIR 807
Query: 667 EICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGV 726
+ + + R + + + + A ++ P + L+ +D EG
Sbjct: 808 RMDER---PIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLV-FDYEGS 863
Query: 727 GSPAGSVGC--CSFIGEDLDDSFLDTLGPKFKKLADI 761
GS AGS+ S G + D +L+ GP+FKKLAD+
Sbjct: 864 GSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADM 900
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 226 bits (577), Expect = 7e-59
Identities = 206/757 (27%), Positives = 334/757 (44%), Gaps = 65/757 (8%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
+RR KR+W+ + E + ++ S+ + ++ Y I+G G D PP G+F +
Sbjct: 102 LRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVE 161
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
++TG + + +DRE + ++ A++ G +E P+ + + V D ND+ P F+ TF
Sbjct: 162 KETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFR 221
Query: 164 GQIEENSNANTLVMILNATDADEP-NNLNSKIAFKIIRQEPSD--SPMFIINRNTGEIRT 220
G + E T VM + ATD D+ N +A+ I QEP D MF I+R+TG I
Sbjct: 222 GSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISV 281
Query: 221 MNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
+++ LDRE+ +Y L ++ +D DG DG + ++ILD NDN P + Y + E
Sbjct: 282 ISSGLDREKVPEYTLTIQATDMDG--DGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPE 339
Query: 281 NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
N + + + V DLD S W A + G++G+ F I + +N GIL K LD+E
Sbjct: 340 NAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFE 399
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS 400
A L + V N+A F + + + I V V +V E PVF P SK V + +
Sbjct: 400 AKNQHTLYVEVTNEAPF----VLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPT 455
Query: 401 NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGK- 459
+ V + A D D + + + Y + +PA LA+D +G++T + +E +
Sbjct: 456 GEPVCVYTAEDPD--KENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNI 513
Query: 460 YQGTILSIDDNLQRTC-TGTININIQSFGNDDRTNTEP-NTKITTNTGRQESTSSTNYDT 517
Y+ +L++D+ T TGT+ + + ND EP I + ++ + T+ D
Sbjct: 514 YEVMVLAMDNGSPPTTGTGTLLLTLIDV-NDHGPVPEPRQITICNQSPVRQVLNITDKDL 572
Query: 518 STTS-------TDSSQVYSSEPGNGAKDLL-----------SDNVHFGPAGIGLLIMGFL 559
S + TD S +Y + N D + + +VH + G +
Sbjct: 573 SPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTV 632
Query: 560 VLGLVPFLMICCDCGGAPRSAAG------FEPVPECSDGAIHSWAVEGPQPEPRDITTVI 613
+ V CDC G + G PV + V +
Sbjct: 633 IRATV------CDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRKIKEP 686
Query: 614 PQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEIC--QE 671
+P D+ DN Y E GG E QD + G E PE+ +
Sbjct: 687 LLLPEDDTR-----DNVFYYGEEGGGEEDQDYDITQLHRGLE--------ARPEVVLRND 733
Query: 672 YSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAG 731
+ T+ M R N + + ++ + A A+ D P D LL++D EG GS A
Sbjct: 734 VAPTIIPTPMYRPRPA--NPDEIGNFIIENLKA-ANTDPTAPPYDTLLVFDYEGSGSDAA 790
Query: 732 SVG--CCSFIGEDLDDSFLDTLGPKFKKLADISLGKE 766
S+ S +D D +L+ G +FKKLAD+ G E
Sbjct: 791 SLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGE 827
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 218 bits (554), Expect = 3e-56
Identities = 138/462 (29%), Positives = 229/462 (49%), Gaps = 4/462 (0%)
Query: 43 SIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVI 102
+++R KR W A+ E + +I SD A N + Y ISG G+D+ P+ +F I
Sbjct: 128 ALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYI 187
Query: 103 NQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATF 162
+ TG+I T +DRE F +Y A + G E PL L +++ D NDN P F
Sbjct: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVT 247
Query: 163 AGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMN 222
+ EN + T V + ATD DEP+ L++++ +KI++Q P F I+ +TG I T
Sbjct: 248 IFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTT 307
Query: 223 NFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENT 282
FLDRE+ Y L + D G G+ I + D NDN P ++SY E++EN
Sbjct: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENR 367
Query: 283 LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAM 342
++ +L ++V D D + + AV + GNE F I + TN G+L VVKPL+YE
Sbjct: 368 IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVN 427
Query: 343 QSLQLSIGVRNKAEFHHSIMSQY-KLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSN 401
+ + L +GV N+A+F + SQ + + ++V +++ EGP P K +
Sbjct: 428 RQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAG 487
Query: 402 DKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQ 461
++ + A D + +RY + + ++ TG L + +E + +Y
Sbjct: 488 QELLGYKALDPEIS-SGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYN 546
Query: 462 GTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTN 503
+++++ D + R+CTGT+ +++ + ND + I N
Sbjct: 547 ISVVAV-DAVGRSCTGTLVVHLDDY-NDHAPQIDKEVTICQN 586
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 218 bits (554), Expect = 3e-56
Identities = 138/462 (29%), Positives = 229/462 (49%), Gaps = 4/462 (0%)
Query: 43 SIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVI 102
+++R KR W A+ E + +I SD A N + Y ISG G+D+ P+ +F I
Sbjct: 128 ALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYI 187
Query: 103 NQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATF 162
+ TG+I T +DRE F +Y A + G E PL L +++ D NDN P F
Sbjct: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVT 247
Query: 163 AGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMN 222
+ EN + T V + ATD DEP+ L++++ +KI++Q P F I+ +TG I T
Sbjct: 248 IFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTT 307
Query: 223 NFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENT 282
FLDRE+ Y L + D G G+ I + D NDN P ++SY E++EN
Sbjct: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENR 367
Query: 283 LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAM 342
++ +L ++V D D + + AV + GNE F I + TN G+L VVKPL+YE
Sbjct: 368 IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVN 427
Query: 343 QSLQLSIGVRNKAEFHHSIMSQY-KLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSN 401
+ + L +GV N+A+F + SQ + + ++V +++ EGP P K +
Sbjct: 428 RQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAG 487
Query: 402 DKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQ 461
++ + A D + +RY + + ++ TG L + +E + +Y
Sbjct: 488 QELLGYKALDPEIS-SGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYN 546
Query: 462 GTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTN 503
+++++ D + R+CTGT+ +++ + ND + I N
Sbjct: 547 ISVVAV-DAVGRSCTGTLVVHLDDY-NDHAPQIDKEVTICQN 586
Score = 93.2 bits (230), Expect = 1e-18
Identities = 166/731 (22%), Positives = 279/731 (38%), Gaps = 114/731 (15%)
Query: 58 CREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITS-IVD 116
CR G K D + ++ Y+I D P + F I+ TG I T+ +D
Sbjct: 255 CRSGTSVGKVTATDLDEPD-TLHTRLKYKILQQIPDHPKH--FSIHPDTGVITTTTPFLD 311
Query: 117 REVTPFFIIYCRALNSMGQD--LERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANT 174
RE + + + GQ L + + + D NDNPP F+ ++ ++EEN +
Sbjct: 312 REKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN-RIDV 370
Query: 175 LVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGE-----IRTMNNFLDREQ 229
++ + D D PN +SK +KI++ + + + + NT E ++ +N ++R+
Sbjct: 371 EILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQV 430
Query: 230 YGQYALAVRGSDRDGGADGMSAECECNI--KILDVNDNIPYMEQSSYTIEIQEN-TLNSN 286
Q + + C + KI+D +D P I+ Q+
Sbjct: 431 ILQVGVINEAQFSKAASSQTPTMCTTTVTVKIID-SDEGPECHPPVKVIQSQDGFPAGQE 489
Query: 287 LLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQ 346
LL + LD E S+ + + G+E NWFEI N+ T G L+ +K LD E
Sbjct: 490 LLGYKA--LDPEISSG-EGLRYQKLGDEDNWFEI--NQHT--GDLRTLKVLDRE------ 536
Query: 347 LSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPG-SKTYVVTGNMGSNDKVG 405
S V+N +++ S+++ + S V+++ + P K + N N+
Sbjct: 537 -SKFVKNN-QYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQN---NEDFA 591
Query: 406 DFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTIL 465
D D ++ + N+ + ++ + GK + + YN Y +
Sbjct: 592 VLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYN-----YYSVPI 646
Query: 466 SIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSS 525
I D T + + + D T +E K D ST
Sbjct: 647 QIKDRHGLVATHMLTVRVC----DCSTPSECRMK----------------DKSTRD---- 682
Query: 526 QVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEP 585
+ NV G I +++G ++L + F C C A R+ P
Sbjct: 683 --------------VRPNVILGRWAILAMVLGSVLLLCILFT---CFCVTAKRTVKKCFP 725
Query: 586 VPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIEC------IDNSGVYTNEY-- 637
I S EGP E +T ++P +NI + + G+ T +
Sbjct: 726 EDIAQQNLIVS-NTEGPGEE---VTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSFE 781
Query: 638 ---GGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFM 694
GG + GG G + E VK G G R + + + +F
Sbjct: 782 MVKGGYTLDSNKGG----GHQTLESVKGVGQ--------GDTGRYAYTDWQ------SFT 823
Query: 695 ESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPK 754
+ +K Y ++E + D + Y+ EG GS AGSVGCCS E+ FLD L PK
Sbjct: 824 QPRLGEKVYLCGQDEEHKHCEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPK 883
Query: 755 FKKLADISLGK 765
F+ LA + K
Sbjct: 884 FRTLAKTCIKK 894
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 212 bits (540), Expect = 1e-54
Identities = 143/444 (32%), Positives = 226/444 (50%), Gaps = 12/444 (2%)
Query: 43 SIRRQKREWIKFAAACREGEDNSKR--NPIAKIHSDCAANQQVTYRISGVGIDQPPYGIF 100
++ R +R W+ + E N KR P+ +I SD V Y I G G+D+ P G+F
Sbjct: 39 ALSRVRRAWVIPPISVSE---NHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVF 95
Query: 101 VINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMA 160
I++ TG++ + +++DRE T F + AL+ G LE P +L + V+D NDN P F
Sbjct: 96 SIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQE 155
Query: 161 TFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRT 220
F G++ E + T V ATDAD+P N+ + F I++Q +F I+ TGEIRT
Sbjct: 156 AFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEIRT 213
Query: 221 MNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
+ LDRE Y L ++ +D G DG++A I + D+NDN P + + +E E
Sbjct: 214 VQVGLDREVVAVYNLTLQVADMSG--DGLTATASAIITLDDINDNAPEFTRDEFFMEAIE 271
Query: 281 NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
++ + V D D S NW+A + G+ F I + +TN G+L +VK LDYE
Sbjct: 272 AVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYE 331
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS 400
+ + +L + V+N+A + + + +A + V V + E PVF+ +
Sbjct: 332 SCEHYELKVSVQNEAPLQAAALRAERGQAK-VRVHVQDTNEPPVFQENPLRTSLAEGAPP 390
Query: 401 NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKY 460
V F A D DT + Y +P D L VD+ TG++ ++ ++ + GG Y
Sbjct: 391 GTLVATFSARDPDT-EQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWY 449
Query: 461 QGTILSIDDNLQ-RTCTGTININI 483
+ +L+ DD Q RT TGT++I I
Sbjct: 450 RAIVLAQDDASQPRTATGTLSIEI 473
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/58 (44%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 706 ADEDEGRPSNDCLLIYDIEGVGSPAGSVG--CCSFIGEDLDDSFLDTLGPKFKKLADI 761
AD D P D LIYD EG GS AG++ S ED D +L GP+F +LAD+
Sbjct: 722 ADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADM 779
>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
Length = 832
Score = 196 bits (499), Expect = 7e-50
Identities = 140/504 (27%), Positives = 248/504 (49%), Gaps = 23/504 (4%)
Query: 8 VVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKR 67
++ +L ++L+ V + + + D + + +RR KR W+ E +
Sbjct: 13 LLLVLLLWLLQVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFP 72
Query: 68 NPIAKIHSDCAANQQVTYRISGVGIDQ-PPYGIFVI-NQKTGEINITSIVDREVTPFFII 125
I ++ ++ + N + Y ISG G+D+ P G+F + + + G I + VDRE+TP F +
Sbjct: 73 KLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTV 132
Query: 126 YCRALN-SMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDA 184
Y + S G+ ++ L +R+ D+ND+ P F F ++EN +A + + A D
Sbjct: 133 YFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDL 192
Query: 185 DEPNNLNSKIAFKIIRQEPS-DSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRD 243
DE N NS++ + +I Q P F ++R +GEIR ++ LD E Q+ L +R RD
Sbjct: 193 DEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIR-LSGCLDYETAPQFTLLIRA--RD 249
Query: 244 GGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANW 303
G +S+ ++ + + N++ P Q +Y ++I E + +L + V D D F++ W
Sbjct: 250 CGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAW 309
Query: 304 MAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEF----HH 359
A + GNE F+I + TN GIL V+KPLDYE + L I V N+
Sbjct: 310 RAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCERG 369
Query: 360 SIMSQYKLKASA-ISVTVLNVIEGPVFRPGSKTYVVTGNMGS--NDKVGDFVATDLDTGR 416
+ K ASA +SV V + + P F P ++++V G+ +G F A D
Sbjct: 370 KLQPPRKAAASATVSVQVTDANDPPAFHP--QSFIVNKEEGARPGTLLGTFNAMD----- 422
Query: 417 PSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNL-QRTC 475
P + +RY + ++PA+ ++VD +G + + +E ++ Y I ++DD +T
Sbjct: 423 PDSQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTA 482
Query: 476 TGTININIQSFGNDDRTNTEPNTK 499
TGT+ + + ND+ P ++
Sbjct: 483 TGTLMLFLSDI-NDNVPTLRPRSR 505
Score = 45.1 bits (105), Expect = 4e-04
Identities = 50/192 (26%), Positives = 91/192 (47%), Gaps = 19/192 (9%)
Query: 145 VRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPS 204
V+V D ND PP F +F EE + TL+ NA D D S+I ++++ +P+
Sbjct: 385 VQVTDAND-PPAFHPQSFIVNKEEGARPGTLLGTFNAMDPD------SQIRYELVH-DPA 436
Query: 205 DSPMFIINRNTGEIRTMNNFLDREQ----YGQYALAVRGSDRDGGADGMSAECECNIKIL 260
+ +++N+G + T+ +DRE Y + + D G +A + +
Sbjct: 437 N--WVSVDKNSGVVITVEP-IDRESPHVNNSFYVIIIHAVD--DGFPPQTATGTLMLFLS 491
Query: 261 DVNDNIPYMEQSSYTIEIQENTLNSNL-LEIRVIDLDEEFSANWMAVIFFISGNEGNWFE 319
D+NDN+P + S +E+ E+ ++ L +E DL E FS + + GN + ++
Sbjct: 492 DINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDL-EPFSDPFTFELDNTWGNAEDTWK 550
Query: 320 IEMNERTNVGIL 331
+ N +V +L
Sbjct: 551 LGRNWGQSVELL 562
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 193 bits (491), Expect = 6e-49
Identities = 139/454 (30%), Positives = 219/454 (48%), Gaps = 13/454 (2%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVIN 103
+ RQKR + E + + K+ D ++ +R++G G+DQ P GIF IN
Sbjct: 133 VPRQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERSKFRLTGKGVDQEPKGIFRIN 191
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFA 163
+ TG +++T +DREV + ++ + G+ LE P+ L V V+D NDN P+F +
Sbjct: 192 ENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSP---MFIINRNTGEIRT 220
G + E S T VM + A DAD+P N+ + + IRQ+ D P MF I+ G+I T
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPATDNALLRYN-IRQQTPDKPSPNMFYIDPEKGDIVT 310
Query: 221 MNN--FLDRE--QYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTI 276
+ + LDRE + +Y L + D G G++ I I D ND+ P + +
Sbjct: 311 VVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQA 370
Query: 277 EIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKP 336
++E + ++ + V D D+ + W A I+GN G FEI N +TN G+L VVKP
Sbjct: 371 TVEEGAVGV-IVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKP 429
Query: 337 LDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTG 396
LDYE L I V N+ + S + + +TVL+V EGPVF P
Sbjct: 430 LDYEISAFHTLLIKVENEDPLVPDV-SYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQE 488
Query: 397 NMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNML 456
++ + ATD D+ T+RY + +PA L ++ G + + +E +
Sbjct: 489 DLSVGSVLLTVNATDPDS-LQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVD 547
Query: 457 GGKYQGTILSIDD-NLQRTCTGTININIQSFGND 489
Y L+ID N T TGT+ I ++ ++
Sbjct: 548 NSVYTALFLAIDSGNPPATGTGTLLITLEDVNDN 581
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 164 bits (415), Expect = 4e-40
Identities = 129/439 (29%), Positives = 210/439 (47%), Gaps = 25/439 (5%)
Query: 45 RRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQ-QVTYRISGVGIDQPPYGIFVIN 103
+R KR W+ E S+ + K+HSD + V Y +SG G +F I+
Sbjct: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFTID 105
Query: 104 QKTGEINITSIVDREVTPFFIIYCRALN-SMGQDLERPLELRVRVLDINDNPPVFSMATF 162
+ TG+I+ +DRE PF+ + +A++ + LE E ++V DINDN P F +
Sbjct: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165
Query: 163 AGQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTGEIRTM 221
+ E S V+ + ATDAD+P NS ++ + I++ +P F I+ TG IRT
Sbjct: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP----YFSIDPKTGVIRTA 221
Query: 222 NNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQEN 281
+DRE QY + ++ D G G++ NI + DVNDN P +S + +++ E+
Sbjct: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281
Query: 282 T-LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
+ + S + IR +D D F N + G+ GN F+I +E T G++K+ KPLD+E
Sbjct: 282 SPIGSAIGRIRAVDPD--FGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKASA-ISVTVLNVIEGPVFRPGSKTYVVTGNMG 399
++ + N H S K +A + ++VL+V E PVF T V +
Sbjct: 340 TKKAYTFKVEASN-LHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTP 398
Query: 400 SNDKVGDFVATDLDTGRPSTTVRYVMG--NNPADLLAVDSRTGKLTLKNKVTKE---QYN 454
+G A DLD G S+ VRY + ++ +D G + + +E QYN
Sbjct: 399 VGTIIGAVTAQDLDVG--SSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYN 456
Query: 455 --MLGGKYQGTILSIDDNL 471
++ K +L+ N+
Sbjct: 457 FSIIASKVSNPLLTSKVNI 475
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 12/144 (8%)
Query: 100 FVINQKTGEINITSIVDREVTP---FFIIYCRALNSMGQDLERPLELRVRVLDINDNPPV 156
F I+ G I ++DRE T F II + N + L + + + VLD+N+ PP
Sbjct: 432 FTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPL---LTSKVNILINVLDVNEFPPE 488
Query: 157 FSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFII---NR 213
S+ + + EN+ ++ I++A D D + + +F+ + E + P F +
Sbjct: 489 ISV-PYETAVCENAKPGQIIQIVSAADRD-LSPAGQQFSFR-LSPEAAIKPNFTVRDFRN 545
Query: 214 NTGEIRTMNNFLDREQYGQYALAV 237
NT I T N R Q Y L V
Sbjct: 546 NTAGIETRRNGYSRRQQELYFLPV 569
Score = 37.7 bits (86), Expect = 0.057
Identities = 26/67 (38%), Positives = 33/67 (49%), Gaps = 3/67 (4%)
Query: 707 DEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSF--LDTLGPKFKKLADISLG 764
D D P D L Y EG GS A S+ + + D + L GP+FK LAD+
Sbjct: 725 DVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGE 784
Query: 765 KESY-PD 770
+ESY PD
Sbjct: 785 EESYNPD 791
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 163 bits (413), Expect = 7e-40
Identities = 194/767 (25%), Positives = 310/767 (40%), Gaps = 71/767 (9%)
Query: 40 KWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDC-AANQQVTYRISGVGIDQPPYG 98
K S +R KR W+ E + + K+HSD + + Y +SG G
Sbjct: 50 KPQSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGI---- 105
Query: 99 IFVINQKTGEINITSIVDREVTPFFIIYCRALNSM-GQDLERPLELRVRVLDINDNPPVF 157
+F I+ TG+I+ +DRE + + +AL+ G+ +E E +++ DINDN P F
Sbjct: 106 VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165
Query: 158 SMATFAGQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTG 216
+ + E S T V+ + ATDAD+P NS ++ + I++ +P F ++ TG
Sbjct: 166 LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQP----YFSVDSKTG 221
Query: 217 EIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTI 276
IRT +DRE Y + ++ D G G++ NI + DVNDN P Q Y +
Sbjct: 222 VIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQM 281
Query: 277 EIQENT-LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVK 335
+ E+ ++S + + DLDE +A I + G+ + F+I + VGI+ V K
Sbjct: 282 SVLESAPISSTVGRVFAKDLDEGINAEMKYTI--VDGDGADAFDISTDPNFQVGIITVKK 339
Query: 336 PLDYEAMQSLQLSI-GVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVV 394
PL +E+ +S L + G E + ++ + + ++V +V E PVF PG V
Sbjct: 340 PLSFESKKSYTLKVEGANPHLEMRFLNLGPFQ-DTTTVHISVEDVDEPPVFEPGFYFVEV 398
Query: 395 TGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYN 454
++ + A D D S ++P VD TG L + +E+++
Sbjct: 399 PEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDREEFS 458
Query: 455 MLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEP---NTKITTNTGRQ---E 508
+ T+L+++ N + G++ + I+ +D P + N +
Sbjct: 459 W----HNITVLAMEMN-NPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQ 513
Query: 509 STSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLM 568
+ S+ + D + E N + DN A I GF F +
Sbjct: 514 TVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDN-QDNTARILTRRSGFRQQEQSVFHL 572
Query: 569 --ICCDCGGAPRSAAGFEPVPECS---DGAIHSWAVEG---PQPEPRDITTVI------- 613
+ D G S+ G + CS DG + S + E P R I
Sbjct: 573 PILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVSLSRGALIAILACIFVL 632
Query: 614 ----------------PQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERM-TGFEL 656
P I D NI E N Y +E GG E + M E
Sbjct: 633 LVLVLLILSMRRHRKQPYIIDDEENIHE---NIVRYDDEGGGEEDTEAFDIAAMWNPREA 689
Query: 657 TEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSND 716
G ++ E +L R + C + + SY K Y AD D P D
Sbjct: 690 QAGAAPKTRQDMLPEIE-SLSRYVPQTCAVN----STVHSYVLAKLYE-ADMDLWAPPFD 743
Query: 717 CLLIYDIEGVGSPAGSVGCCSFIGEDLDDS--FLDTLGPKFKKLADI 761
L Y EG GS AGS+ D + S FL GP+F+KLA++
Sbjct: 744 SLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAEL 790
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 157 bits (398), Expect = 4e-38
Identities = 122/414 (29%), Positives = 203/414 (49%), Gaps = 20/414 (4%)
Query: 46 RQKREWIKFAAACREGEDNSKRNPIAKIHSDC-AANQQVTYRISGVGIDQPPYGIFVINQ 104
R KR W+ E + K+HS+ + V Y ++G G IF+I+
Sbjct: 50 RPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGT----IFIIDD 105
Query: 105 KTGEINITSIVDREVTPFFIIYCRALNSM-GQDLERPLELRVRVLDINDNPPVFSMATFA 163
TG+I+ T +DRE ++++ +A++ + LE E ++V DINDN P F+ +
Sbjct: 106 TTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYI 165
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTGEIRTMN 222
+ E S+ T V+ + ATDAD+P NS ++ + I++ +P F ++ TG IRT
Sbjct: 166 VTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQP----YFSVDPKTGVIRTAL 221
Query: 223 NFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENT 282
+ +DRE Y++ ++ D G G+S NI + DVNDN P Q Y + + E+
Sbjct: 222 HNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESA 281
Query: 283 -LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEA 341
+ S + +I+ D D +A+ I I+G+ F I ++ T GIL + KPL+YE
Sbjct: 282 QVGSAVGKIKANDADTGSNADMTYSI--INGDGMGIFSISTDKETREGILSLKKPLNYEK 339
Query: 342 MQSLQLSI-GVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS 400
+S L+I G +F S + +K A+ + + V +V E P+F S V N
Sbjct: 340 KKSYTLNIEGANTHLDFRFSHLGPFK-DATMLKIIVGDVDEPPLFSMPSYLMEVYENAKI 398
Query: 401 NDKVGDFVATDLDTGRPSTTVRYVMGNNPAD--LLAVDSRTGKLTLKNKVTKEQ 452
VG +A D D+ ++ VRY + N D +D+ TG + + +E+
Sbjct: 399 GTVVGTVLAQDPDS--TNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREE 450
Score = 67.0 bits (162), Expect = 9e-11
Identities = 53/168 (31%), Positives = 83/168 (49%), Gaps = 10/168 (5%)
Query: 143 LRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQE 202
L++ V D+ D PP+FSM ++ ++ EN+ T+V + A D D N+L I
Sbjct: 370 LKIIVGDV-DEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSL----VRYFINYN 424
Query: 203 PSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDV 262
D F I+ NTG IRT LDRE+ Y + V S+ D + + I++LDV
Sbjct: 425 VEDDRFFNIDANTGTIRT-TKVLDREETPWYNITVTASEIDN--PDLLSHVTVGIRVLDV 481
Query: 263 NDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFI 310
NDN P + + Y I + EN+ ++ + D++ AN FF+
Sbjct: 482 NDNPPELAR-EYDIIVCENSKPGQVIH-TISATDKDDFANGPRFNFFL 527
Score = 60.1 bits (144), Expect = 1e-08
Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 8/163 (4%)
Query: 100 FVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSM 159
F I+ TG I T ++DRE TP++ I A DL + + +RVLD+NDNPP +
Sbjct: 431 FNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELA- 489
Query: 160 ATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFII---NRNTG 216
+ + ENS ++ ++ATD D+ N + F + + P +P F + NT
Sbjct: 490 REYDIIVCENSKPGQVIHTISATDKDDFAN-GPRFNFFLDERLPV-NPNFTLKDNEDNTA 547
Query: 217 EIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKI 259
I T R Y L + S DGG +S+ I++
Sbjct: 548 SILTRRRRFSRTVQDVYYLPIMIS--DGGIPSLSSSSTLTIRV 588
Score = 39.3 bits (90), Expect = 0.020
Identities = 40/125 (32%), Positives = 55/125 (44%), Gaps = 11/125 (8%)
Query: 644 DLGGGERMT-GFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESY----F 698
D GGGE T F++T S E+ +Y +R R + +ES F
Sbjct: 660 DEGGGEEDTEAFDITALRNPSAAEEL--KYRRDIRPEVKLTPRHQ--TSSTLESIDVQEF 715
Query: 699 CQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCC--SFIGEDLDDSFLDTLGPKFK 756
++ A AD D P D L Y EG S AGS+ + D D +L GP+FK
Sbjct: 716 IKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFK 775
Query: 757 KLADI 761
KLA++
Sbjct: 776 KLAEL 780
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 154 bits (388), Expect = 5e-37
Identities = 115/416 (27%), Positives = 195/416 (46%), Gaps = 18/416 (4%)
Query: 42 HSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDC-AANQQVTYRISGVGIDQPPYGIF 100
+ + R KR W+ E S + K+HSD + + Y +SG G +F
Sbjct: 46 NELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD----LF 101
Query: 101 VINQKTGEINITSIVDREVTPFFIIYCRALNSM-GQDLERPLELRVRVLDINDNPPVFSM 159
+IN+ TG+I T +DRE P +I+ +A+N G+ +E E +++ DINDN P+F+
Sbjct: 102 IINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTK 161
Query: 160 ATFAGQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTGEI 218
+ + E S+ T V+ + ATDAD+P NS K+ + I++ +P F + TG I
Sbjct: 162 EVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP----YFSVESETGII 217
Query: 219 RTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEI 278
+T +DRE QY + ++ D G G+S NI + DVNDN P QS+Y +
Sbjct: 218 KTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKT 277
Query: 279 QENT-LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEG-NWFEIEMNERTNVGILKVVKP 336
E++ + + I+ D D +A + + I+ EG + F++ ++ T GI+ V K
Sbjct: 278 PESSPPGTPIGRIKASDADVGENAE---IEYSITDGEGLDMFDVITDQETQEGIITVKKL 334
Query: 337 LDYEAMQSLQLSIGVRNK-AEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVT 395
LD+E + L + N E + +K ++ + + V +V E PVF + +
Sbjct: 335 LDFEKKKVYTLKVEASNPYVEPRFLYLGPFK-DSATVRIVVEDVDEPPVFSKLAYILQIR 393
Query: 396 GNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKE 451
+ N +G A D D R + + +DS G + + +E
Sbjct: 394 EDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRE 449
Score = 70.1 bits (170), Expect = 1e-11
Identities = 77/328 (23%), Positives = 139/328 (42%), Gaps = 33/328 (10%)
Query: 62 EDNSKRNPIAKIHS---DCAANQQVTYRIS-GVGIDQPPYGIFVINQKTGE--INITSIV 115
E + PI +I + D N ++ Y I+ G G+D + +Q+T E I + ++
Sbjct: 279 ESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDV---ITDQETQEGIITVKKLL 335
Query: 116 DREVTPFFIIYCRALNSMGQD-------LERPLELRVRVLDINDNPPVFSMATFAGQIEE 168
D E + + A N + + +R+ V D+ D PPVFS + QI E
Sbjct: 336 DFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFSKLAYILQIRE 394
Query: 169 NSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE 228
++ NT + + A D D N + + + R D +F I+ G I T + LDRE
Sbjct: 395 DAQINTTIGSVTAQDPDAARN---PVKYSVDRHTDMDR-IFNIDSGNGSIFT-SKLLDRE 449
Query: 229 QYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLL 288
+ + V ++ + S+ IK+LDVNDN P + T ++ + +
Sbjct: 450 TLLWHNITVIATEINNPKQ--SSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQ 507
Query: 289 EIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLS 348
+ +D D+ +S + + G+ F I+ N+ GIL + M + L
Sbjct: 508 TLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLP 567
Query: 349 IGVRNKAEFHHSIMSQYKLKASAISVTV 376
+ + + + Y +++S +VTV
Sbjct: 568 VVISD---------NDYPVQSSTGTVTV 586
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/66 (39%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 707 DEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSF--LDTLGPKFKKLADISLG 764
D D P D L Y EG GS A S+ + D D + L GP+FKKLAD+ G
Sbjct: 724 DTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGG 783
Query: 765 KESYPD 770
+S D
Sbjct: 784 VDSDKD 789
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 152 bits (383), Expect = 2e-36
Identities = 112/384 (29%), Positives = 181/384 (47%), Gaps = 16/384 (4%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDC-AANQQVTYRISGVGIDQPPYGIFVI 102
++R KR W+ E + ++HSD + + + Y +SG G IFVI
Sbjct: 48 LQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGT----IFVI 103
Query: 103 NQKTGEINITSIVDREVTPFFIIYCRALN-SMGQDLERPLELRVRVLDINDNPPVFSMAT 161
+ K+G I+ T +DRE + + +A++ + LE P E V+V DINDNPP F T
Sbjct: 104 DDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHET 163
Query: 162 FAGQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTGEIRT 220
+ + E SN T V+ + A+DAD+P NS K+ + I+ + P F + TG IRT
Sbjct: 164 YHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQ----PYFSVEAQTGIIRT 219
Query: 221 MNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
+DRE +Y + ++ D G G+S + I + DVNDN P QS Y + + E
Sbjct: 220 ALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSE 279
Query: 281 NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
+ + RV D + N + + G+ FEI + T G++K+ KP+D+E
Sbjct: 280 AAVPGEEVG-RVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFE 338
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKAS-AISVTVLNVIEGPVFRPGSKTYVVTGNMG 399
++ L + N +S K + + ++V + E P+F S + V N
Sbjct: 339 TKRAYSLKVEAAN-VHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAA 397
Query: 400 SNDKVGDFVATDLDTGRPSTTVRY 423
+ VG A D D ++ +RY
Sbjct: 398 AGTVVGRVHAKDPDAA--NSPIRY 419
Score = 54.7 bits (130), Expect = 5e-07
Identities = 60/209 (28%), Positives = 93/209 (44%), Gaps = 19/209 (9%)
Query: 78 AANQQVTYRISG-VGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQD 136
AAN + Y I +D+ F IN + G I T +DRE T + I A +
Sbjct: 412 AANSPIRYSIDRHTDLDR----FFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRH 467
Query: 137 LERPLELRVRVLDINDNPPVFSMATFAGQIEENSN----ANTLVMILNATDADEPNNLNS 192
E + + +RVLD+NDN P F+ A + G I E+ +N ++ ++A D D+ N
Sbjct: 468 QEAKVPVAIRVLDVNDNAPKFA-APYEGFICESDQTKPLSNQPIVTISADDKDDTAN-GP 525
Query: 193 KIAFKIIRQEPSDSPMFII--NR-NTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGM 249
+ F + E +P F + NR NT + R++ Y L + S DGG M
Sbjct: 526 RFIFS-LPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVIS--DGGIPPM 582
Query: 250 SAECECNIKI--LDVNDNIPYMEQSSYTI 276
S+ IK+ DVN + +Y +
Sbjct: 583 SSTNTLTIKVCGCDVNGALLSCNAEAYIL 611
Score = 50.1 bits (118), Expect = 1e-05
Identities = 28/67 (41%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 706 ADEDEGRPSNDCLLIYDIEGVGSPAGSVGCC--SFIGEDLDDSFLDTLGPKFKKLADISL 763
AD D P D + IY EG GS AGS+ + DLD +L GP+FKKLAD+
Sbjct: 728 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYG 787
Query: 764 GKESYPD 770
K+++ D
Sbjct: 788 SKDTFDD 794
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 150 bits (378), Expect = 8e-36
Identities = 107/383 (27%), Positives = 176/383 (45%), Gaps = 12/383 (3%)
Query: 43 SIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVT-YRISGVGIDQPPYGIFV 101
++ R +R W+ E + I K+HSD + T Y ++G G +FV
Sbjct: 38 ALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGT----VFV 93
Query: 102 INQKTGEINITSIVDREVTPFFIIYCRALN-SMGQDLERPLELRVRVLDINDNPPVFSMA 160
I++ TG I++T +DRE +++ +A++ + + LE P E ++V DINDNPP+F +
Sbjct: 94 IDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLG 153
Query: 161 TFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRT 220
+ + E SN T V+ + A DAD+P+ NS K++ P F ++ TG +RT
Sbjct: 154 PYHATVPEMSNVGTSVIQVTAHDADDPSYGNSA---KLVYTVLDGLPFFSVDPQTGVVRT 210
Query: 221 MNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
+DRE ++ + ++ D G G+S + + DVNDN P QS Y + E
Sbjct: 211 AIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVE 270
Query: 281 NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
T L R+ D + N + + G F I + + G+L V KPLD+E
Sbjct: 271 -TAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFE 329
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS 400
+ +S + N + +++ V V + E P F + V N
Sbjct: 330 SQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAP 389
Query: 401 NDKVGDFVATDLDTGRPSTTVRY 423
VG A DLD+ P++ +RY
Sbjct: 390 GTLVGQISAADLDS--PASPIRY 410
Score = 35.4 bits (80), Expect = 0.28
Identities = 25/68 (36%), Positives = 33/68 (48%), Gaps = 10/68 (14%)
Query: 706 ADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSF-------LDTLGPKFKKL 758
ADED G P D + +Y EG GS GS+ S +G + LD GP F+ L
Sbjct: 713 ADEDPGVPPYDSVQVYGYEGRGSSCGSL---SSLGSGSEAGGAPGPAEPLDDWGPLFRTL 769
Query: 759 ADISLGKE 766
A++ KE
Sbjct: 770 AELYGAKE 777
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 150 bits (378), Expect = 8e-36
Identities = 107/383 (27%), Positives = 176/383 (45%), Gaps = 12/383 (3%)
Query: 43 SIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVT-YRISGVGIDQPPYGIFV 101
++ R +R W+ E + I K+HSD + T Y ++G G +FV
Sbjct: 38 ALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGT----VFV 93
Query: 102 INQKTGEINITSIVDREVTPFFIIYCRALN-SMGQDLERPLELRVRVLDINDNPPVFSMA 160
I++ TG I++T +DRE +++ +A++ + + LE P E ++V DINDNPP+F +
Sbjct: 94 IDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLG 153
Query: 161 TFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRT 220
+ + E SN T V+ + A DAD+P+ NS K++ P F ++ TG +RT
Sbjct: 154 PYHATVPEMSNVGTSVIQVTAHDADDPSYGNSA---KLVYTVLDGLPFFSVDPQTGVVRT 210
Query: 221 MNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
+DRE ++ + ++ D G G+S + + DVNDN P QS Y + E
Sbjct: 211 AIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVE 270
Query: 281 NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYE 340
T L R+ D + N + + G F I + + G+L V KPLD+E
Sbjct: 271 -TAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFE 329
Query: 341 AMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS 400
+ +S + N + +++ V V + E P F + V N
Sbjct: 330 SQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAP 389
Query: 401 NDKVGDFVATDLDTGRPSTTVRY 423
VG A DLD+ P++ +RY
Sbjct: 390 GTLVGQISAADLDS--PASPIRY 410
Score = 35.4 bits (80), Expect = 0.28
Identities = 25/68 (36%), Positives = 33/68 (48%), Gaps = 10/68 (14%)
Query: 706 ADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSF-------LDTLGPKFKKL 758
ADED G P D + +Y EG GS GS+ S +G + LD GP F+ L
Sbjct: 751 ADEDPGVPPYDSVQVYGYEGRGSSCGSL---SSLGSGSEAGGAPGPAEPLDDWGPLFRTL 807
Query: 759 ADISLGKE 766
A++ KE
Sbjct: 808 AELYGAKE 815
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 145 bits (366), Expect = 2e-34
Identities = 114/412 (27%), Positives = 192/412 (46%), Gaps = 18/412 (4%)
Query: 46 RQKREWIKFAAACREGEDNSKRNPIAKIHSDC-AANQQVTYRISGVGIDQPPYGIFVINQ 104
R KR W+ E S + K+HSD + + Y +SG G IF+I++
Sbjct: 44 RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IFIIDE 99
Query: 105 KTGEINITSIVDREVTPFFIIYCRALNSM-GQDLERPLELRVRVLDINDNPPVFSMATFA 163
TG+I+ T +DRE ++ + +AL+ + + +E E +++ DINDN P F +
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTGEIRTMN 222
+ E S T V+ + ATDAD+P NS ++ + I++ +P F + TG I+T
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
Query: 223 NFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENT 282
+DRE QY L ++ D G G+S + + DVNDN P + SY + E+
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
Query: 283 LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAM 342
++++ R+ D + AN + G+ F+I +++ T GI+ + K LD+EA
Sbjct: 276 PVASVV-ARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAK 334
Query: 343 QSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSND 402
S L I NK + + + + V +V E PVF V+ +
Sbjct: 335 TSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGN 394
Query: 403 KVGDFVATDLDTGRPSTTVRYVMGNNPADL---LAVDSRTGKLTLKNKVTKE 451
+G A D D+ ++ VRY + N DL +D+ +G +T + +E
Sbjct: 395 IIGTVAAHDPDSS--NSPVRYSIDRN-TDLERYFNIDANSGVITTAKSLDRE 443
Score = 55.1 bits (131), Expect = 3e-07
Identities = 65/270 (24%), Positives = 110/270 (40%), Gaps = 27/270 (10%)
Query: 75 SDCAANQQVTYRISGVGIDQPPYGIFVIN----QKTGEINITSIVDREVTPFFIIYCRAL 130
+D AN ++ Y+I +D GIF I+ + G I I +D E + + A
Sbjct: 289 ADIGANAEMEYKI----VDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAA 344
Query: 131 N--------SMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNAT 182
N S+G +++ V D+ D PPVFS + ++ E + I+
Sbjct: 345 NKDADPRFLSLGP-FSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGN---IIGTV 399
Query: 183 DADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDR 242
A +P++ NS + + I R + F I+ N+G I T + LDRE + + V +
Sbjct: 400 AAHDPDSSNSPVRYSIDRNTDLER-YFNIDANSGVITTAKS-LDRETNAIHNITVLAMES 457
Query: 243 DGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLE-IRVIDLDEEFSA 301
+ I ILD+NDN P Y + EN +++ I +D DE +
Sbjct: 458 QNPSQ--VGRGYVAITILDINDNAPEFAM-DYETTVCENAQPGQVIQKISAVDKDEPSNG 514
Query: 302 NWMAVIFFISGNEGNWFEIEMNERTNVGIL 331
+ + F ++ N+ IL
Sbjct: 515 HQFYFSLTTDATNNHNFSLKDNKDNTASIL 544
Score = 52.4 bits (124), Expect = 2e-06
Identities = 48/190 (25%), Positives = 80/190 (42%), Gaps = 9/190 (4%)
Query: 74 HSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSM 133
H ++N V Y I D Y F I+ +G I +DRE I A+ S
Sbjct: 402 HDPDSSNSPVRYSIDR-NTDLERY--FNIDANSGVITTAKSLDRETNAIHNITVLAMESQ 458
Query: 134 GQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSK 193
+ + +LDINDN P F+M + + EN+ ++ ++A D DEP+N +
Sbjct: 459 NPSQVGRGYVAITILDINDNAPEFAM-DYETTVCENAQPGQVIQKISAVDKDEPSN-GHQ 516
Query: 194 IAFKIIRQEPSDSPMFIINR--NTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSA 251
F + ++ + + NT I T N R++ Y L + D G+ +S+
Sbjct: 517 FYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPI--FIVDSGSPSLSS 574
Query: 252 ECECNIKILD 261
I++ D
Sbjct: 575 TNTLTIRVCD 584
Score = 42.7 bits (99), Expect = 0.002
Identities = 27/65 (41%), Positives = 35/65 (53%), Gaps = 3/65 (4%)
Query: 706 ADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDS--FLDTLGPKFKKLADI-S 762
AD D G P D L Y EG GS A S+ I + D + +L GP+FK+LAD+
Sbjct: 718 ADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
Query: 763 LGKES 767
G+ES
Sbjct: 778 TGQES 782
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 145 bits (366), Expect = 2e-34
Identities = 114/412 (27%), Positives = 192/412 (46%), Gaps = 18/412 (4%)
Query: 46 RQKREWIKFAAACREGEDNSKRNPIAKIHSDC-AANQQVTYRISGVGIDQPPYGIFVINQ 104
R KR W+ E S + K+HSD + + Y +SG G IF+I++
Sbjct: 44 RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IFIIDE 99
Query: 105 KTGEINITSIVDREVTPFFIIYCRALNSM-GQDLERPLELRVRVLDINDNPPVFSMATFA 163
TG+I+ T +DRE ++ + +AL+ + + +E E +++ DINDN P F +
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159
Query: 164 GQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTGEIRTMN 222
+ E S T V+ + ATDAD+P NS ++ + I++ +P F + TG I+T
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215
Query: 223 NFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENT 282
+DRE QY L ++ D G G+S + + DVNDN P + SY + E+
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275
Query: 283 LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAM 342
++++ R+ D + AN + G+ F+I +++ T GI+ + K LD+EA
Sbjct: 276 PVASVV-ARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAK 334
Query: 343 QSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSND 402
S L I NK + + + + V +V E PVF V+ +
Sbjct: 335 TSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGN 394
Query: 403 KVGDFVATDLDTGRPSTTVRYVMGNNPADL---LAVDSRTGKLTLKNKVTKE 451
+G A D D+ ++ VRY + N DL +D+ +G +T + +E
Sbjct: 395 IIGTVAAHDPDSS--NSPVRYSIDRN-TDLERYFNIDANSGVITTAKSLDRE 443
Score = 55.1 bits (131), Expect = 3e-07
Identities = 65/270 (24%), Positives = 110/270 (40%), Gaps = 27/270 (10%)
Query: 75 SDCAANQQVTYRISGVGIDQPPYGIFVIN----QKTGEINITSIVDREVTPFFIIYCRAL 130
+D AN ++ Y+I +D GIF I+ + G I I +D E + + A
Sbjct: 289 ADIGANAEMEYKI----VDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAA 344
Query: 131 N--------SMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNAT 182
N S+G +++ V D+ D PPVFS + ++ E + I+
Sbjct: 345 NKDADPRFLSLGP-FSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGN---IIGTV 399
Query: 183 DADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDR 242
A +P++ NS + + I R + F I+ N+G I T + LDRE + + V +
Sbjct: 400 AAHDPDSSNSPVRYSIDRNTDLER-YFNIDANSGVITTAKS-LDRETNAIHNITVLAMES 457
Query: 243 DGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLE-IRVIDLDEEFSA 301
+ I ILD+NDN P Y + EN +++ I +D DE +
Sbjct: 458 QNPSQ--VGRGYVAITILDINDNAPEFAM-DYETTVCENAQPGQVIQKISAVDKDEPSNG 514
Query: 302 NWMAVIFFISGNEGNWFEIEMNERTNVGIL 331
+ + F ++ N+ IL
Sbjct: 515 HQFYFSLTTDATNNHNFSLKDNKDNTASIL 544
Score = 52.4 bits (124), Expect = 2e-06
Identities = 48/190 (25%), Positives = 80/190 (42%), Gaps = 9/190 (4%)
Query: 74 HSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSM 133
H ++N V Y I D Y F I+ +G I +DRE I A+ S
Sbjct: 402 HDPDSSNSPVRYSIDR-NTDLERY--FNIDANSGVITTAKSLDRETNAIHNITVLAMESQ 458
Query: 134 GQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSK 193
+ + +LDINDN P F+M + + EN+ ++ ++A D DEP+N +
Sbjct: 459 NPSQVGRGYVAITILDINDNAPEFAM-DYETTVCENAQPGQVIQKISAVDKDEPSN-GHQ 516
Query: 194 IAFKIIRQEPSDSPMFIINR--NTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSA 251
F + ++ + + NT I T N R++ Y L + D G+ +S+
Sbjct: 517 FYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPI--FIVDSGSPSLSS 574
Query: 252 ECECNIKILD 261
I++ D
Sbjct: 575 TNTLTIRVCD 584
Score = 42.7 bits (99), Expect = 0.002
Identities = 27/65 (41%), Positives = 35/65 (53%), Gaps = 3/65 (4%)
Query: 706 ADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDS--FLDTLGPKFKKLADI-S 762
AD D G P D L Y EG GS A S+ I + D + +L GP+FK+LAD+
Sbjct: 718 ADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
Query: 763 LGKES 767
G+ES
Sbjct: 778 TGQES 782
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 144 bits (363), Expect = 4e-34
Identities = 106/376 (28%), Positives = 183/376 (48%), Gaps = 16/376 (4%)
Query: 44 IRRQKREWIKFAAACREGEDNSKRNPIAKIHSDC-AANQQVTYRISGVGIDQPPYGIFVI 102
+ RQKR W+ E S + K+HSD + + Y +SG G +F+I
Sbjct: 49 LHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGT----LFII 104
Query: 103 NQKTGEINITSIVDREVTPFFIIYCRALNSMG-QDLERPLELRVRVLDINDNPPVFSMAT 161
++KTG+I+ T +DRE F+ + +A+N + +E E +++ DINDN P F
Sbjct: 105 DEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEI 164
Query: 162 FAGQIEENSNANTLVMILNATDADEPNNLNS-KIAFKIIRQEPSDSPMFIINRNTGEIRT 220
+ + E S T V+ + ATDAD+P+ NS ++ + I++ +P F + TG IRT
Sbjct: 165 YTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQP----YFSVEPETGIIRT 220
Query: 221 MNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE 280
++RE QY + ++ D G G+S NI + DVNDN P Q++ + + E
Sbjct: 221 ALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLE 280
Query: 281 NT-LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDY 339
++ + + + ++ D D N I G+ + F+I + T GI+ V KPLDY
Sbjct: 281 SSPVGTAIGSVKATDADT--GKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDY 338
Query: 340 EAMQSLQLSIGVRN-KAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNM 398
E+ + L + N + + +K + + +++ +V E PVF S + V ++
Sbjct: 339 ESRRLYTLKVEAENTHVDPRFYYLGPFK-DTTIVKISIEDVDEPPVFSRSSYLFEVHEDI 397
Query: 399 GSNDKVGDFVATDLDT 414
+G +A D D+
Sbjct: 398 EVGTIIGTVMARDPDS 413
Score = 63.2 bits (152), Expect = 1e-09
Identities = 78/365 (21%), Positives = 152/365 (41%), Gaps = 35/365 (9%)
Query: 195 AFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECE 254
+ K I +FII+ TG+I +DRE+ Y L + +R + E E
Sbjct: 88 SLKYILSGDGAGTLFIIDEKTGDIHATRR-IDREEKAFYTLRAQAINRRT-LRPVEPESE 145
Query: 255 CNIKILDVNDNIPYMEQSSYTIEIQE-NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGN 313
IKI D+NDN P + YT + E + + ++++++ D D+ N VI+ I
Sbjct: 146 FVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQG 205
Query: 314 EGNWFEIEMNERTNVGILKVVKP-LDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAI 372
+ +F +E GI++ P ++ E + Q+ I ++ + + +
Sbjct: 206 QP-YFSVE----PETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSG-----TTTV 255
Query: 373 SVTVLNVIEGPVFRPGSKTYV-VTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPAD 431
++T+ +V + P P + ++ V + +G ATD DTG+ + ++ + D
Sbjct: 256 NITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTD 315
Query: 432 LLAV----DSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQR----TCTGTININI 483
+ + D++ G +T+K + E + K + +D T + I+I
Sbjct: 316 MFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISI 375
Query: 484 Q-----------SFGNDDRTNTEPNTKITTNTGRQ-ESTSSTNYDTSTTSTDSSQVYSSE 531
+ S+ + + E T I T R +S SS + TD ++++
Sbjct: 376 EDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIH 435
Query: 532 PGNGA 536
GNG+
Sbjct: 436 SGNGS 440
Score = 53.1 bits (126), Expect = 1e-06
Identities = 66/270 (24%), Positives = 116/270 (42%), Gaps = 30/270 (11%)
Query: 75 SDCAANQQVTYRI-SGVGIDQPPYGIFVINQKT---GEINITSIVDREVTPFFIIYCRAL 130
+D N +V YRI G G D ++ +K G I + +D E + + A
Sbjct: 296 ADTGKNAEVEYRIIDGDGTDM----FDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAE 351
Query: 131 NS--------MGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNAT 182
N+ +G + + +++ + D+ D PPVFS +++ ++ E+ T++ + A
Sbjct: 352 NTHVDPRFYYLGPFKDTTI-VKISIEDV-DEPPVFSRSSYLFEVHEDIEVGTIIGTVMAR 409
Query: 183 DADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDR 242
D P++++S I F + R D +F I+ G + T LDRE + L V ++
Sbjct: 410 D---PDSISSPIRFSLDRHTDLDR-IFNIHSGNGSLYTSKP-LDRELSQWHNLTVIAAEI 464
Query: 243 DGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLE-IRVIDLDEEFSA 301
+ + + ++ILDVNDN P Y + EN L++ I +D D+
Sbjct: 465 NNPKE--TTRVAVFVRILDVNDNAPQF-AVFYDTFVCENARPGQLIQTISAVDKDDPLGG 521
Query: 302 NWMAVIFFISGNEGNWFEIEMNERTNVGIL 331
FF F ++ NE IL
Sbjct: 522 Q---KFFFSLAAVNPNFTVQDNEDNTARIL 548
Score = 49.3 bits (116), Expect = 2e-05
Identities = 40/148 (27%), Positives = 66/148 (44%), Gaps = 9/148 (6%)
Query: 99 IFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFS 158
IF I+ G + + +DRE++ + + A + + VR+LD+NDN P F+
Sbjct: 431 IFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFA 490
Query: 159 MATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFII---NRNT 215
+ + + EN+ L+ ++A D D+P K F + P+ F + NT
Sbjct: 491 V-FYDTFVCENARPGQLIQTISAVDKDDPLG-GQKFFFSLAAVNPN----FTVQDNEDNT 544
Query: 216 GEIRTMNNFLDREQYGQYALAVRGSDRD 243
I T N +R + Y L V SD D
Sbjct: 545 ARILTRKNGFNRHEISTYLLPVVISDND 572
>gi|221316595 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 139 bits (350), Expect = 1e-32
Identities = 99/350 (28%), Positives = 164/350 (46%), Gaps = 21/350 (6%)
Query: 100 FVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSM 159
F I+Q+ G+I +T +DRE ++ Y A + G+ L PLE+ V+V DINDNPP
Sbjct: 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPS 342
Query: 160 ATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPS--DSPMFIINRNTGE 217
+++EN + L A D DE N NS + ++I+ Q P +F+I G
Sbjct: 343 PVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGM 402
Query: 218 IRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSY-TI 276
++ L ++ QY L + SD+D C I ++D+ND IP E+S Y +
Sbjct: 403 LQLAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYGNL 457
Query: 277 EIQENT-LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVK 335
+ E+T + S +L I+ D DE F+ + + I G+ ++ + TN G + + K
Sbjct: 458 TLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKK 517
Query: 336 PLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASA---ISVTVLNVIEGPVFRPGSKTY 392
PLD+E + KAE ++ K AS+ ++ V +V E P F
Sbjct: 518 PLDFETAAVSNIVF----KAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQA 573
Query: 393 VVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKL 442
V+ ++ KVG+ A D + + Y + + L +D TG++
Sbjct: 574 KVSEDVAIGTKVGNVTAKDPE----GLDISYSLRGDTRGWLKIDHVTGEI 619
Score = 72.0 bits (175), Expect = 3e-12
Identities = 96/395 (24%), Positives = 169/395 (42%), Gaps = 36/395 (9%)
Query: 99 IFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFS 158
IFVI ++ G + +DRE + AL++ G +E P+ + ++V DINDN P F
Sbjct: 69 IFVI-EREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127
Query: 159 MATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEP--SDSPMFIINRNTG 216
+ + G + +NS + +NATD D+P N ++ ++I+ Q P ++ F IN TG
Sbjct: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187
Query: 217 EI---RTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSS 273
I R + L+ + Y L + D GG S ++ I+ V +NI ++
Sbjct: 188 AISLTREGSQELNPAKNPSYNLVISVKDM-GGQSENSFSDTTSVDII-VTENI---WKAP 242
Query: 274 YTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKV 333
+E+ EN+ + + ++I + ++ A + + F +++ G + V
Sbjct: 243 KPVEMVENSTDPHPIKITQVRWNDP-----GAQYSLVDKEKLPRFPFSIDQE---GDIYV 294
Query: 334 VKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKT-Y 392
+PLD E + +++ + Y L+ I V V ++ + P P T +
Sbjct: 295 TQPLDREEKDAYVFYAVAKDE----YGKPLSYPLE---IHVKVKDINDNPPTCPSPVTVF 347
Query: 393 VVTGNMGSNDKVGDFVATDLD---TGRPSTTVRYV--MGNNPAD-LLAVDSRTGKLTLKN 446
V N + +G A D D T R V P D L + + G L L
Sbjct: 348 EVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAK 407
Query: 447 KVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTINI 481
+ K+Q +Y TI D + + C IN+
Sbjct: 408 QSLKKQDT---PQYNLTIEVSDKDFKTLCFVQINV 439
Score = 34.7 bits (78), Expect = 0.48
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 14/122 (11%)
Query: 147 VLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDS 206
V D+N+ P FS F ++ E+ T V + A D P L+ + + D+
Sbjct: 557 VTDVNEAPQ-FSQHVFQAKVSEDVAIGTKVGNVTAKD---PEGLDISYSLR------GDT 606
Query: 207 PMFI-INRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDN 265
++ I+ TGEI ++ LDRE Y + V ++ G + +S+ E ++ ++DVNDN
Sbjct: 607 RGWLKIDHVTGEIFSVAP-LDREAGSPYRVQVVATEVGGSS--LSSVSEFHLILMDVNDN 663
Query: 266 IP 267
P
Sbjct: 664 PP 665
Score = 33.5 bits (75), Expect = 1.1
Identities = 19/58 (32%), Positives = 28/58 (48%)
Query: 98 GIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPP 155
G I+ TGEI + +DRE + + A G L E + ++D+NDNPP
Sbjct: 608 GWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPP 665
>gi|221316593 cadherin 17 precursor [Homo sapiens]
Length = 832
Score = 139 bits (350), Expect = 1e-32
Identities = 99/350 (28%), Positives = 164/350 (46%), Gaps = 21/350 (6%)
Query: 100 FVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSM 159
F I+Q+ G+I +T +DRE ++ Y A + G+ L PLE+ V+V DINDNPP
Sbjct: 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPS 342
Query: 160 ATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPS--DSPMFIINRNTGE 217
+++EN + L A D DE N NS + ++I+ Q P +F+I G
Sbjct: 343 PVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGM 402
Query: 218 IRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSY-TI 276
++ L ++ QY L + SD+D C I ++D+ND IP E+S Y +
Sbjct: 403 LQLAKQSLKKQDTPQYNLTIEVSDKD-----FKTLCFVQINVIDINDQIPIFEKSDYGNL 457
Query: 277 EIQENT-LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVK 335
+ E+T + S +L I+ D DE F+ + + I G+ ++ + TN G + + K
Sbjct: 458 TLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKK 517
Query: 336 PLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASA---ISVTVLNVIEGPVFRPGSKTY 392
PLD+E + KAE ++ K AS+ ++ V +V E P F
Sbjct: 518 PLDFETAAVSNIVF----KAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQA 573
Query: 393 VVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKL 442
V+ ++ KVG+ A D + + Y + + L +D TG++
Sbjct: 574 KVSEDVAIGTKVGNVTAKDPE----GLDISYSLRGDTRGWLKIDHVTGEI 619
Score = 72.0 bits (175), Expect = 3e-12
Identities = 96/395 (24%), Positives = 169/395 (42%), Gaps = 36/395 (9%)
Query: 99 IFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFS 158
IFVI ++ G + +DRE + AL++ G +E P+ + ++V DINDN P F
Sbjct: 69 IFVI-EREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPTFL 127
Query: 159 MATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEP--SDSPMFIINRNTG 216
+ + G + +NS + +NATD D+P N ++ ++I+ Q P ++ F IN TG
Sbjct: 128 QSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYFQINNKTG 187
Query: 217 EI---RTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSS 273
I R + L+ + Y L + D GG S ++ I+ V +NI ++
Sbjct: 188 AISLTREGSQELNPAKNPSYNLVISVKDM-GGQSENSFSDTTSVDII-VTENI---WKAP 242
Query: 274 YTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKV 333
+E+ EN+ + + ++I + ++ A + + F +++ G + V
Sbjct: 243 KPVEMVENSTDPHPIKITQVRWNDP-----GAQYSLVDKEKLPRFPFSIDQE---GDIYV 294
Query: 334 VKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKT-Y 392
+PLD E + +++ + Y L+ I V V ++ + P P T +
Sbjct: 295 TQPLDREEKDAYVFYAVAKDE----YGKPLSYPLE---IHVKVKDINDNPPTCPSPVTVF 347
Query: 393 VVTGNMGSNDKVGDFVATDLD---TGRPSTTVRYV--MGNNPAD-LLAVDSRTGKLTLKN 446
V N + +G A D D T R V P D L + + G L L
Sbjct: 348 EVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAK 407
Query: 447 KVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTINI 481
+ K+Q +Y TI D + + C IN+
Sbjct: 408 QSLKKQDT---PQYNLTIEVSDKDFKTLCFVQINV 439
Score = 34.7 bits (78), Expect = 0.48
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 14/122 (11%)
Query: 147 VLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDS 206
V D+N+ P FS F ++ E+ T V + A D P L+ + + D+
Sbjct: 557 VTDVNEAPQ-FSQHVFQAKVSEDVAIGTKVGNVTAKD---PEGLDISYSLR------GDT 606
Query: 207 PMFI-INRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDN 265
++ I+ TGEI ++ LDRE Y + V ++ G + +S+ E ++ ++DVNDN
Sbjct: 607 RGWLKIDHVTGEIFSVAP-LDREAGSPYRVQVVATEVGGSS--LSSVSEFHLILMDVNDN 663
Query: 266 IP 267
P
Sbjct: 664 PP 665
Score = 33.5 bits (75), Expect = 1.1
Identities = 19/58 (32%), Positives = 28/58 (48%)
Query: 98 GIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPP 155
G I+ TGEI + +DRE + + A G L E + ++D+NDNPP
Sbjct: 608 GWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPP 665
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,227,318
Number of Sequences: 37866
Number of extensions: 2075221
Number of successful extensions: 11474
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 249
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 6395
Number of HSP's gapped (non-prelim): 2795
length of query: 1049
length of database: 18,247,518
effective HSP length: 113
effective length of query: 936
effective length of database: 13,968,660
effective search space: 13074665760
effective search space used: 13074665760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.