Search of human proteins with 119395748

Search of human proteins with 119395748

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119395748 potassium voltage-gated channel subfamily A member
1 [Homo sapiens]
         (495 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119395748 potassium voltage-gated channel subfamily A member ...   990   0.0  
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   776   0.0  
gi|88758565 potassium voltage-gated channel, shaker-related subf...   706   0.0  
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   656   0.0  
gi|25952087 potassium voltage-gated channel, shaker-related subf...   613   e-175
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   605   e-173
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   582   e-166
gi|25952092 potassium voltage-gated channel, shaker-related subf...   568   e-162
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   280   2e-75
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   278   8e-75
gi|163792201 Shaw-related voltage-gated potassium channel protei...   278   8e-75
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   275   5e-74
gi|88758576 Shaw-related voltage-gated potassium channel protein...   271   1e-72
gi|24497462 Shaw-related voltage-gated potassium channel protein...   271   1e-72
gi|24497464 Shaw-related voltage-gated potassium channel protein...   271   1e-72
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   270   3e-72
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   265   7e-71
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   265   7e-71
gi|21217561 Shaw-related voltage-gated potassium channel protein...   258   9e-69
gi|21217563 Shaw-related voltage-gated potassium channel protein...   258   9e-69
gi|24497458 Shaw-related voltage-gated potassium channel protein...   258   9e-69
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   258   1e-68
gi|24497460 Shaw-related voltage-gated potassium channel protein...   242   6e-64
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   235   6e-62
gi|20070166 potassium voltage-gated channel, subfamily F, member...   234   2e-61
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   233   4e-61
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   230   2e-60
gi|19071574 potassium voltage-gated channel, subfamily G, member...   224   2e-58
gi|27436993 potassium voltage-gated channel, subfamily G, member...   219   4e-57
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    216   4e-56

>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  990 bits (2560), Expect = 0.0
 Identities = 495/495 (100%), Positives = 495/495 (100%)

Query: 1   MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 60
           MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN
Sbjct: 1   MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 60

Query: 61  TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY 120
           TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY
Sbjct: 61  TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY 120

Query: 121 ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS 180
           ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS
Sbjct: 121 ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS 180

Query: 181 IVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRF 240
           IVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRF
Sbjct: 181 IVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRF 240

Query: 241 FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF 300
           FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF
Sbjct: 241 FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF 300

Query: 301 RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP 360
           RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP
Sbjct: 301 RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP 360

Query: 361 DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE 420
           DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE
Sbjct: 361 DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE 420

Query: 421 GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTT 480
           GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTT
Sbjct: 421 GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTT 480

Query: 481 ANQNCVNKSKLLTDV 495
           ANQNCVNKSKLLTDV
Sbjct: 481 ANQNCVNKSKLLTDV 495


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  776 bits (2005), Expect = 0.0
 Identities = 404/503 (80%), Positives = 440/503 (87%), Gaps = 12/503 (2%)

Query: 1   MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 60
           MTV +G+  DEA+A PGHPQD +Y  +ADH   ECCERVVINISGLRFETQLKTLAQFP 
Sbjct: 1   MTVATGDPADEAAALPGHPQD-TYDPEADH---ECCERVVINISGLRFETQLKTLAQFPE 56

Query: 61  TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY 120
           TLLG+PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLD+FSEEI+FY
Sbjct: 57  TLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFY 116

Query: 121 ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS 180
           ELGEEAME FREDEG+IKEEERPLPE E+QRQVWLLFEYPESSGPAR+IAIVSVMVILIS
Sbjct: 117 ELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILIS 176

Query: 181 IVIFCLETLPELKDD-KDFTG---TVHRIDNTTVIY-NSNIFTDPFFIVETLCIIWFSFE 235
           IV FCLETLP  +D+ +D  G   T H   N+T+ Y  S  FTDPFFIVETLCIIWFSFE
Sbjct: 177 IVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFE 236

Query: 236 LVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ-EGNQKGEQATSLAILRVI 294
            +VRFFACPSK  FF NIMN IDIVAIIPYFITLGTE+AE+ E  Q+G+QA SLAILRVI
Sbjct: 237 FLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVI 296

Query: 295 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 354
           RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEA+E ES
Sbjct: 297 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERES 356

Query: 355 HFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 414
            F SIPDAFWWAVVSMTTVGYGDM P TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF
Sbjct: 357 QFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 416

Query: 415 YHRETEGEEQAQLLHVSS-PNLASDSDLSR-RSSSTMSKSEYMEIEEDMNNSIAHYRQVN 472
           YHRETEGEEQAQ L V+S P + S  DL + RS+ST+SKS+YMEI+E +NNS   +R+ N
Sbjct: 417 YHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREEN 476

Query: 473 IRTANCTTANQNCVNKSKLLTDV 495
           ++TANCT AN N VN +K+LTDV
Sbjct: 477 LKTANCTLANTNYVNITKMLTDV 499


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  706 bits (1823), Expect = 0.0
 Identities = 380/528 (71%), Positives = 431/528 (81%), Gaps = 38/528 (7%)

Query: 1   MTVMSGENVDEASAAPGH---PQDGSYPRQADH-----------DDHECC-ERVVINISG 45
           MTV+ G+++ E   A G    PQ G      D             + +CC ERVVINISG
Sbjct: 53  MTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISG 112

Query: 46  LRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRP 105
           LRFETQLKTL QFP TLLG+PK+RMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGR+RRP
Sbjct: 113 LRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRP 172

Query: 106 VNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGP 165
           VNVP+D+FSEEI+FY+LGEEAMEKFREDEGF++EEERPLP +++QRQVWLLFEYPESSGP
Sbjct: 173 VNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGP 232

Query: 166 ARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNS--------NIF 217
           AR IAIVSV+VILISIVIFCLETLPE +D+KD+  +  + D+     NS        + F
Sbjct: 233 ARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQ-DSFEAAGNSTSGSRAGASSF 291

Query: 218 TDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQE 277
           +DPFF+VETLCIIWFSFEL+VRFFACPSK  F +NIMN IDIVAIIPYFITLGTE+AE++
Sbjct: 292 SDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQ 351

Query: 278 GNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGV 337
           GN  G+QA SLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGV
Sbjct: 352 GN--GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGV 409

Query: 338 ILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGV 397
           ILFSSAVYFAEA++  S FSSIPDAFWWAVV+MTTVGYGDM+PVTIGGKIVGSLCAIAGV
Sbjct: 410 ILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGV 469

Query: 398 LTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSS-PNLASDSDLSR--RSSSTMSKSEY 454
           LTIALPVPVIVSNFNYFYHRETEGEEQ+Q +HV S  +L+S ++  R  RS+ST+SKSEY
Sbjct: 470 LTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEY 529

Query: 455 MEIEE-DMNNSIAHYRQVNIRTAN----CTTAN--QNCVNKSKLLTDV 495
           M IEE  MN+S   + Q   +T N    CTT N   +CVN  K+ TDV
Sbjct: 530 MVIEEGGMNHSA--FPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV 575


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  656 bits (1692), Expect = 0.0
 Identities = 345/505 (68%), Positives = 400/505 (79%), Gaps = 19/505 (3%)

Query: 10  DEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKR 69
           DE S     PQD      +     +CCERVVIN+SGLRFETQ+KTLAQFP TLLG+P+KR
Sbjct: 149 DECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKR 208

Query: 70  MRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEK 129
            +YFDPLRNEYFFDRNRPSFDAILYYYQSGGRL+RPVNVP D+F+EE+KFY+LGEEA+ K
Sbjct: 209 TQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLK 268

Query: 130 FREDEGFIKEEE-RPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLET 188
           FREDEGF++EEE R LPE E+++Q+WLLFEYPESS PAR IAIVSV+VILISIVIFCLET
Sbjct: 269 FREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLET 328

Query: 189 LPELKDDKDFT------GTVHRIDNTTVIYNSN----IFTDPFFIVETLCIIWFSFELVV 238
           LPE +DD+D        G    +++T+  +  N    IF DPFFIVET+CI+WFSFE VV
Sbjct: 329 LPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVV 388

Query: 239 RFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQ--ATSLAILRVIRL 296
           R FACPS+  FFKNIMN IDIV+I+PYFITLGT++A+Q+G   G+Q  A S AILR+IRL
Sbjct: 389 RCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRL 448

Query: 297 VRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHF 356
           VRVFRIFKLSRHSKGLQILG TL+ASMRELGLLIFFLFIGVILFSSAVYFAEA+E  +HF
Sbjct: 449 VRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHF 508

Query: 357 SSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 416
            SIPDAFWWAVV+MTTVGYGDM P+T+GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH
Sbjct: 509 QSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 568

Query: 417 RETEGEEQAQLLH--VSSPNLASDSDLSRRSSSTMS---KSEYMEIEEDMNNSI-AHYRQ 470
           RETE EEQ QL    VS P L S+     RSS++ S   KSEY+E+EE +  S+ A   +
Sbjct: 569 RETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEK 628

Query: 471 VNIRTANCTTANQNCVNKSKLLTDV 495
              +  +  T   NC N   + TDV
Sbjct: 629 CQGKGDDSETDKNNCSNAKAVETDV 653


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  613 bits (1581), Expect = e-175
 Identities = 311/416 (74%), Positives = 348/416 (83%), Gaps = 25/416 (6%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 96
           +RV INISGLRFETQL TLAQFPNTLLG+P KR+RYFDPLRNEYFFDRNRPSFD ILYYY
Sbjct: 120 QRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYY 179

Query: 97  QSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLL 156
           QSGGRLRRPVNV LD+F++EI+FY+LG+EAME+FREDEGFIKEEE+PLP  E+QRQVWL+
Sbjct: 180 QSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLI 239

Query: 157 FEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDF------------------ 198
           FEYPESSG AR IAIVSV+VILISI+ FCLETLPE +D+++                   
Sbjct: 240 FEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGAN 299

Query: 199 -TGTVHRIDNTTVI-YNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNF 256
            +G +      TV         DPFFIVET C+IWF+FEL+VRFFACPSK  F +NIMN 
Sbjct: 300 GSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNI 359

Query: 257 IDIVAIIPYFITLGTEIAEQE-----GNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKG 311
           ID+VAI PYFITLGTE+AEQ+     G Q G+QA SLAILRVIRLVRVFRIFKLSRHSKG
Sbjct: 360 IDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKG 419

Query: 312 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMT 371
           LQILG+TL+ASMRELGLLIFFLFIGVILFSSAVYFAEA+   +HFSSIPDAFWWAVV+MT
Sbjct: 420 LQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMT 479

Query: 372 TVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQL 427
           TVGYGDM P+T+GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET+ EE A L
Sbjct: 480 TVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVL 535


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  605 bits (1561), Expect = e-173
 Identities = 323/503 (64%), Positives = 376/503 (74%), Gaps = 54/503 (10%)

Query: 11  EASAAPGHPQD-GSYPRQADHDDHECC--ERVVINISGLRFETQLKTLAQFPNTLLGNPK 67
           E     G  QD G +P         CC  ER+VINISGLRFETQL+TL+ FP+TLLG+P 
Sbjct: 14  EVRGPEGEQQDAGDFPEAGGGGG--CCSSERLVINISGLRFETQLRTLSLFPDTLLGDPG 71

Query: 68  KRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAM 127
           +R+R+FDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLD+F EEI+FY+LG+EA+
Sbjct: 72  RRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEAL 131

Query: 128 EKFREDEGFIKE---EERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIF 184
             FREDEG + E   +E+PLP + +QRQVWLLFEYPESSGPAR IAIVSV+VILISIVIF
Sbjct: 132 AAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIF 191

Query: 185 CLETLPELK-------------------------DDKDFTGTVHRI----------DNTT 209
           CLETLP+ +                         +D+D + T H             ++ 
Sbjct: 192 CLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSL 251

Query: 210 VIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITL 269
                + FTDPFF+VETLCI+WF+FEL+VRF ACPSK  FF+NIMN ID+VAI PYFITL
Sbjct: 252 STLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITL 311

Query: 270 GTEIAEQE--------GNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 321
           GTE+ +Q+        G Q G+QA SLAILRVIRLVRVFRIFKLSRHSKGLQILG+TL+A
Sbjct: 312 GTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQA 371

Query: 322 SMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPV 381
           SMRELGLLIFFLFIGVILFSSAVYFAEA++ +S F SIPDAFWWAVV+MTTVGYGDMYP+
Sbjct: 372 SMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPM 431

Query: 382 TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDL 441
           T+GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE EEQ Q  HV+    A D   
Sbjct: 432 TVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPD--- 488

Query: 442 SRRSSSTMSKSEYMEIEEDMNNS 464
            R + + + K ++ E   +   S
Sbjct: 489 LRATDNGLGKPDFPEANRERRPS 511


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  582 bits (1501), Expect = e-166
 Identities = 283/392 (72%), Positives = 334/392 (85%), Gaps = 2/392 (0%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 96
           +RV+INI+GLRFETQL+TL+QFP TLLG+ +KRM++FD +RNEYFFDRNRPSFD ILYYY
Sbjct: 86  QRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYY 145

Query: 97  QSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLL 156
           QSGG++RRP NVP+D+F++EI FYELG EAM++FREDEGFIK+ E  LP  +  RQ WLL
Sbjct: 146 QSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLL 205

Query: 157 FEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVH-RIDNTTVIYNSN 215
           FEYPESS  AR +A+VSV+V++ISI IFCLETLPE ++D++        ++ +  + +  
Sbjct: 206 FEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQT 265

Query: 216 IFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAE 275
           +FTDPFF+VE+ CI+WF+FELV+RF  CPSKTDFF+NIMN IDI++IIPYF TL TE+  
Sbjct: 266 MFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELV- 324

Query: 276 QEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI 335
           QE     +Q  SLAILR+IRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI
Sbjct: 325 QETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI 384

Query: 336 GVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIA 395
           GVILFSSAVYFAE +E ESHFSSIPD FWWAVV+MTTVGYGDM P T GGKIVG+LCAIA
Sbjct: 385 GVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIA 444

Query: 396 GVLTIALPVPVIVSNFNYFYHRETEGEEQAQL 427
           GVLTIALPVPVIVSNFNYFYHRETE EE+  +
Sbjct: 445 GVLTIALPVPVIVSNFNYFYHRETENEEKQNI 476


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  568 bits (1465), Expect = e-162
 Identities = 281/408 (68%), Positives = 331/408 (81%), Gaps = 14/408 (3%)

Query: 35  CCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILY 94
           CCER+V+N++GLRFET+ +TL +FP+TLLG+P +R R++D  R EYFFDR+RPSFDA+LY
Sbjct: 11  CCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLY 70

Query: 95  YYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVW 154
           YYQSGGRLRRP +VPLD+F EE+ FY LG  A+ + REDEG     ERPLP + + RQ+W
Sbjct: 71  YYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLW 130

Query: 155 LLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRID-------- 206
           LLFE+PESS  ARV+A+VSV+VIL+SIV+FCLETLP+ +DD+D TG              
Sbjct: 131 LLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPL 190

Query: 207 NTTVIYNSNI----FTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAI 262
           N +     N     F DPFF+VETLCI WFSFEL+VR   CPSK  FFKN+MN ID VAI
Sbjct: 191 NGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAI 250

Query: 263 IPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKAS 322
           +PYF+ LGTE+A Q G   G+QA SLAILRVIRLVRVFRIFKLSRHSKGLQILGQTL+AS
Sbjct: 251 LPYFVALGTELARQRG--VGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRAS 308

Query: 323 MRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382
           MRELGLLIFFLFIGV+LFSSAVYFAE +  +SHF+SIP++FWWAVV+MTTVGYGDM PVT
Sbjct: 309 MRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVT 368

Query: 383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHV 430
           +GGKIVGSLCAIAGVLTI+LPVPVIVSNF+YFYHRETEGEE     HV
Sbjct: 369 VGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHV 416


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  280 bits (717), Expect = 2e-75
 Identities = 171/459 (37%), Positives = 259/459 (56%), Gaps = 50/459 (10%)

Query: 35  CCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLR---------NEYFFDRN 85
           C  RV +N+ GL  E   +TL + P T LG  +    +   L          NEYFFDR+
Sbjct: 29  CSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRH 88

Query: 86  RPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME---------KFREDEGF 136
             +F +IL +Y++G RL     +    FS+E+ ++ + E  +E         K  +    
Sbjct: 89  PGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEE 147

Query: 137 IKEEERPLPEKEYQ-----------RQVWLLFEYPESSGPARVIAIVSVMVILISIVIFC 185
           +K E   L E+E +           +++W L E P SS  A+++AI+S+M I++S +   
Sbjct: 148 LKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALS 207

Query: 186 LETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPS 245
           L TLPEL+   +F  +    DN  + +           VE +CI WF+ E ++RF + P 
Sbjct: 208 LNTLPELQSLDEFGQST---DNPQLAH-----------VEAVCIAWFTMEYLLRFLSSPK 253

Query: 246 KTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA-ILRVIRLVRVFRIFK 304
           K  FFK  +N ID++AI+PY++T    I   E N+   Q  ++  ++++ R++R+ RI K
Sbjct: 254 KWKFFKGPLNAIDLLAILPYYVT----IFLTESNKSVLQFQNVRRVVQIFRIMRILRILK 309

Query: 305 LSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFW 364
           L+RHS GLQ LG TL+ S  ELGLLI FL +G+++FSS V+FAE +E ++ F SIP +FW
Sbjct: 310 LARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFW 369

Query: 365 WAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424
           WA ++MTTVGYGD+YP T+ GKIVG LC IAGVL IALP+P+IV+NF+ FY  +   E+ 
Sbjct: 370 WATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKA 429

Query: 425 AQLLHVSSPNLASDSDLSRRSSSTMSKS-EYMEIEEDMN 462
            +          + S +S       ++S E M+I  + N
Sbjct: 430 IKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKN 468


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  278 bits (711), Expect = 8e-75
 Identities = 165/423 (39%), Positives = 254/423 (60%), Gaps = 54/423 (12%)

Query: 35  CCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLR---------NEYFFDRN 85
           C  RV IN+ GL  E   +TL + P T LG  +    +   L          NEYFFDR+
Sbjct: 33  CSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRH 92

Query: 86  RPSFDAILYYYQSGGRLRRPVNVPLDMFSEEI----------------KFYELGEEAMEK 129
             +F +IL +Y++G +L     +    F +E+                ++++  E+  E+
Sbjct: 93  PGAFTSILNFYRTG-KLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEE 151

Query: 130 FREDEGFIKEEERP------LPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVI 183
            R +   ++E E         P+K  ++++W L E P SS  A+++AIVS++ I++S + 
Sbjct: 152 LRREAETMREREGEEFDNTCCPDK--RKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIA 209

Query: 184 FCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFAC 243
             L TLPEL++  +F G ++  DN  + +           VE +CI WF+ E ++RF + 
Sbjct: 210 LSLNTLPELQETDEF-GQLN--DNRQLAH-----------VEAVCIAWFTMEYLLRFLSS 255

Query: 244 PSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA-ILRVIRLVRVFRI 302
           P+K  FFK  +N ID++AI+PY++T    I   E N+   Q  ++  ++++ R++R+ RI
Sbjct: 256 PNKWKFFKGPLNVIDLLAILPYYVT----IFLTESNKSVLQFQNVRRVVQIFRIMRILRI 311

Query: 303 FKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDA 362
            KL+RHS GLQ LG TL+ S  ELGLLI FL +G+++FSS V+FAE +E  + F+SIP +
Sbjct: 312 LKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPAS 371

Query: 363 FWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGE 422
           FWWA ++MTTVGYGD+YP T+ GKIVG LC IAGVL IALP+P+IV+NF+ FY +E + +
Sbjct: 372 FWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY-KEQKRQ 430

Query: 423 EQA 425
           E+A
Sbjct: 431 EKA 433


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  278 bits (711), Expect = 8e-75
 Identities = 185/528 (35%), Positives = 273/528 (51%), Gaps = 79/528 (14%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLG---NPKKRMRY-FDPLRNEYFFDRNRPSFDAI 92
           ER+VIN+ G R +T   TL   P T L     P     + +DP  +E+FFDR+   F  I
Sbjct: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67

Query: 93  LYYYQSGGRLRRPVNVPLDMFSEEIKFYEL------------------GEEAMEKFRE-- 132
           L YY++G +L  P +V   ++ EE+ F+ +                   EEA++ F    
Sbjct: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126

Query: 133 --------------DEGFIKEEERPLPE---------------KEYQRQVWLLFEYPESS 163
                         D G  ++E                     + +Q ++W LFE P SS
Sbjct: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186

Query: 164 GPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFI 223
             AR +A  S+  IL+SI  FCLET        + T   +  + T V Y     T+ F  
Sbjct: 187 RYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLT 246

Query: 224 -VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKG 282
            +E +C++WF+FE ++R   CP+K +F KN +N ID VAI+P+++ +G       G    
Sbjct: 247 YIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS-----GLSSK 301

Query: 283 EQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSS 342
                L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++
Sbjct: 302 AAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFAT 361

Query: 343 AVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCA 393
            +Y+AE   A+         +HF +IP  FWWAVV+MTT+GYGDMYP T  G +VG+LCA
Sbjct: 362 MIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA 421

Query: 394 IAGVLTIALPVPVIVSNFNYFYHRETEGEE--QAQLLHV------SSPNLASDSDLSRRS 445
           +AGVLTIA+PVPVIV+NF  +Y      ++  + +  H+       SPN    S ++   
Sbjct: 422 LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCK-SVVNSPH 480

Query: 446 SSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLT 493
            ST S +  +  EE +  + A   ++N   A    AN++C +  + LT
Sbjct: 481 HSTQSDTCPLAQEEILEINRAD-SKLNGEVAKAALANEDCPHIDQALT 527


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  275 bits (704), Expect = 5e-74
 Identities = 167/442 (37%), Positives = 238/442 (53%), Gaps = 69/442 (15%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLG---NPKKRMRY-FDPLRNEYFFDRNRPSFDAI 92
           ER+VIN+ G R +T   TL   P T L     P     + +DP  +E+FFDR+   F  I
Sbjct: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67

Query: 93  LYYYQSGGRLRRPVNVPLDMFSEEIKFYEL------------------GEEAMEKFRE-- 132
           L YY++G +L  P +V   ++ EE+ F+ +                   EEA++ F    
Sbjct: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126

Query: 133 --------------DEGFIKEEERPLPE---------------KEYQRQVWLLFEYPESS 163
                         D G  ++E                     + +Q ++W LFE P SS
Sbjct: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186

Query: 164 GPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFI 223
             AR +A  S+  IL+SI  FCLET        + T   +  + T V Y     T+ F  
Sbjct: 187 RYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLT 246

Query: 224 -VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKG 282
            +E +C++WF+FE ++R   CP+K +F KN +N ID VAI+P+++ +G       G    
Sbjct: 247 YIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS-----GLSSK 301

Query: 283 EQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSS 342
                L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++
Sbjct: 302 AAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFAT 361

Query: 343 AVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCA 393
            +Y+AE   A+         +HF +IP  FWWAVV+MTT+GYGDMYP T  G +VG+LCA
Sbjct: 362 MIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA 421

Query: 394 IAGVLTIALPVPVIVSNFNYFY 415
           +AGVLTIA+PVPVIV+NF  +Y
Sbjct: 422 LAGVLTIAMPVPVIVNNFGMYY 443


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  271 bits (692), Expect = 1e-72
 Identities = 167/453 (36%), Positives = 240/453 (52%), Gaps = 77/453 (16%)

Query: 34  ECCERVVINISGLRFETQLKTLAQFPNTLL---------GNPKKRMRYFDPLRN------ 78
           E  E+++IN+ G R ET   TL   P T L         G P+          +      
Sbjct: 33  EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGC 92

Query: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 93  EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151

Query: 123 --GEEAMEKFREDEGF---------IKEEERPLPEKE-------------------YQRQ 152
              EEA++ F   +G            ++ER L  +                    +Q +
Sbjct: 152 RDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPR 211

Query: 153 VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIY 212
           +W LFE P SS  ARV+A  S+  IL+SI  FCLET      D++ T  +   + T+V +
Sbjct: 212 MWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHF 271

Query: 213 NSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGT 271
              + T+P    +E +C++WF+ E +VR   CP   DF KN++N ID VAI+P+++ +G 
Sbjct: 272 RREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGL 331

Query: 272 EIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIF 331
                 G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI 
Sbjct: 332 S-----GLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386

Query: 332 FLFIGVILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382
           FL +GV++F++ +Y+AE   A          + F +IP  FWWAVV+MTT+GYGDMYP T
Sbjct: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446

Query: 383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 415
             G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  271 bits (692), Expect = 1e-72
 Identities = 167/453 (36%), Positives = 240/453 (52%), Gaps = 77/453 (16%)

Query: 34  ECCERVVINISGLRFETQLKTLAQFPNTLL---------GNPKKRMRYFDPLRN------ 78
           E  E+++IN+ G R ET   TL   P T L         G P+          +      
Sbjct: 33  EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGC 92

Query: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 93  EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151

Query: 123 --GEEAMEKFREDEGF---------IKEEERPLPEKE-------------------YQRQ 152
              EEA++ F   +G            ++ER L  +                    +Q +
Sbjct: 152 RDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPR 211

Query: 153 VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIY 212
           +W LFE P SS  ARV+A  S+  IL+SI  FCLET      D++ T  +   + T+V +
Sbjct: 212 MWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHF 271

Query: 213 NSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGT 271
              + T+P    +E +C++WF+ E +VR   CP   DF KN++N ID VAI+P+++ +G 
Sbjct: 272 RREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGL 331

Query: 272 EIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIF 331
                 G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI 
Sbjct: 332 S-----GLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386

Query: 332 FLFIGVILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382
           FL +GV++F++ +Y+AE   A          + F +IP  FWWAVV+MTT+GYGDMYP T
Sbjct: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446

Query: 383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 415
             G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  271 bits (692), Expect = 1e-72
 Identities = 167/453 (36%), Positives = 240/453 (52%), Gaps = 77/453 (16%)

Query: 34  ECCERVVINISGLRFETQLKTLAQFPNTLL---------GNPKKRMRYFDPLRN------ 78
           E  E+++IN+ G R ET   TL   P T L         G P+          +      
Sbjct: 33  EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGC 92

Query: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 93  EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151

Query: 123 --GEEAMEKFREDEGF---------IKEEERPLPEKE-------------------YQRQ 152
              EEA++ F   +G            ++ER L  +                    +Q +
Sbjct: 152 RDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPR 211

Query: 153 VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIY 212
           +W LFE P SS  ARV+A  S+  IL+SI  FCLET      D++ T  +   + T+V +
Sbjct: 212 MWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHF 271

Query: 213 NSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGT 271
              + T+P    +E +C++WF+ E +VR   CP   DF KN++N ID VAI+P+++ +G 
Sbjct: 272 RREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGL 331

Query: 272 EIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIF 331
                 G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI 
Sbjct: 332 S-----GLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386

Query: 332 FLFIGVILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382
           FL +GV++F++ +Y+AE   A          + F +IP  FWWAVV+MTT+GYGDMYP T
Sbjct: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446

Query: 383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 415
             G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  270 bits (689), Expect = 3e-72
 Identities = 160/406 (39%), Positives = 241/406 (59%), Gaps = 39/406 (9%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 96
           E +V+N+SG RFET   TL ++P+TLLG+ +K   ++D    EYFFDR+   F  +L +Y
Sbjct: 40  EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFY 98

Query: 97  QSGGRLRRPVNVPLDMFSEEIKFYEL-----GEEAMEKFR-----------EDEGFIKEE 140
           ++G RL  P    +  F EE+ FY L     G+  +E++R           EDE   +  
Sbjct: 99  RTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAG 157

Query: 141 ERP-LPEKEYQRQ-VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDF 198
           + P LP     RQ +W  FE P +S  A V   V+   I +S++   +ET+P        
Sbjct: 158 DGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP-------C 210

Query: 199 TGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFID 258
            G+  R            F   FF ++T C++ F+ E ++R FA PS+  F +++M+ ID
Sbjct: 211 RGSARRSSREQPC--GERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLID 268

Query: 259 IVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQT 318
           +VAI+PY+I L   +  +  +  G   T       +R+ RVFRIFK SRHS+GL+ILG T
Sbjct: 269 VVAILPYYIGL---LVPKNDDVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYT 318

Query: 319 LKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDM 378
           LK+   ELG L+F L + +I+F++ +++AE    +++F+SIP AFW+ +V+MTT+GYGDM
Sbjct: 319 LKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDM 378

Query: 379 YPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424
            P TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 379 VPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 424


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  265 bits (677), Expect = 7e-71
 Identities = 148/403 (36%), Positives = 241/403 (59%), Gaps = 38/403 (9%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 96
           E +V+N+SG RF+T   TL ++P+TLLG+ +K   +F+    EYFFDR+   F  +L +Y
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFY 98

Query: 97  QSGGRLRRPVNVPLDMFSEEIKFYEL-----GEEAMEKFRE----------DEGFIKEEE 141
           ++G +L  P    +  + +E+ FY +     G+   E++++          D+   +  +
Sbjct: 99  RTG-KLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQ 157

Query: 142 RPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGT 201
             +P   +++ +W  FE P +S  A V   V+   I +S++   +ET+P         GT
Sbjct: 158 ESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVP--------CGT 209

Query: 202 VHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVA 261
           V     +  +     ++  FF ++T C++ F+ E ++R FA PS+  F +++M+ ID+VA
Sbjct: 210 V---PGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVA 266

Query: 262 IIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 321
           I+PY+I L   +     +  G   T       +R+ RVFRIFK SRHS+GL+ILG TLK+
Sbjct: 267 IMPYYIGL---VMTNNEDVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYTLKS 316

Query: 322 SMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPV 381
              ELG L+F L + +I+F++ +++AE   + S F+SIP +FW+ +V+MTT+GYGDM P 
Sbjct: 317 CASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPK 376

Query: 382 TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424
           TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 377 TIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 419


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  265 bits (677), Expect = 7e-71
 Identities = 148/403 (36%), Positives = 241/403 (59%), Gaps = 38/403 (9%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 96
           E +V+N+SG RF+T   TL ++P+TLLG+ +K   +F+    EYFFDR+   F  +L +Y
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFY 98

Query: 97  QSGGRLRRPVNVPLDMFSEEIKFYEL-----GEEAMEKFRE----------DEGFIKEEE 141
           ++G +L  P    +  + +E+ FY +     G+   E++++          D+   +  +
Sbjct: 99  RTG-KLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQ 157

Query: 142 RPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGT 201
             +P   +++ +W  FE P +S  A V   V+   I +S++   +ET+P         GT
Sbjct: 158 ESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVP--------CGT 209

Query: 202 VHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVA 261
           V     +  +     ++  FF ++T C++ F+ E ++R FA PS+  F +++M+ ID+VA
Sbjct: 210 V---PGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVA 266

Query: 262 IIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 321
           I+PY+I L   +     +  G   T       +R+ RVFRIFK SRHS+GL+ILG TLK+
Sbjct: 267 IMPYYIGL---VMTNNEDVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYTLKS 316

Query: 322 SMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPV 381
              ELG L+F L + +I+F++ +++AE   + S F+SIP +FW+ +V+MTT+GYGDM P 
Sbjct: 317 CASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPK 376

Query: 382 TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424
           TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 377 TIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 419


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  258 bits (659), Expect = 9e-69
 Identities = 156/388 (40%), Positives = 218/388 (56%), Gaps = 59/388 (15%)

Query: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 123 --GEEAMEKFREDE--GFIKEEERPLPEKEY---------------------QRQVWLLF 157
              EEA++ F   +  G    ++  L  K                       Q ++W LF
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219

Query: 158 EYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIF 217
           E P SS  AR IA  S+  IL+SI  FCLET       K+ T  V  I+ T+V+    I 
Sbjct: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV--INGTSVVLQYEIE 277

Query: 218 TDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ 276
           TDP    VE +C++WF+FE +VR    P+K +F KN++N ID VAI+P+++ +G      
Sbjct: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLS---- 333

Query: 277 EGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 336
            G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +G
Sbjct: 334 -GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392

Query: 337 VILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKI 387
           V++F++ +Y+AE   A+         + F +IP  FWWAVV+MTT+GYGDMYP T  G +
Sbjct: 393 VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452

Query: 388 VGSLCAIAGVLTIALPVPVIVSNFNYFY 415
           VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 453 VGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  258 bits (659), Expect = 9e-69
 Identities = 156/388 (40%), Positives = 218/388 (56%), Gaps = 59/388 (15%)

Query: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 123 --GEEAMEKFREDE--GFIKEEERPLPEKEY---------------------QRQVWLLF 157
              EEA++ F   +  G    ++  L  K                       Q ++W LF
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219

Query: 158 EYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIF 217
           E P SS  AR IA  S+  IL+SI  FCLET       K+ T  V  I+ T+V+    I 
Sbjct: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV--INGTSVVLQYEIE 277

Query: 218 TDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ 276
           TDP    VE +C++WF+FE +VR    P+K +F KN++N ID VAI+P+++ +G      
Sbjct: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLS---- 333

Query: 277 EGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 336
            G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +G
Sbjct: 334 -GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392

Query: 337 VILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKI 387
           V++F++ +Y+AE   A+         + F +IP  FWWAVV+MTT+GYGDMYP T  G +
Sbjct: 393 VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452

Query: 388 VGSLCAIAGVLTIALPVPVIVSNFNYFY 415
           VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 453 VGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  258 bits (659), Expect = 9e-69
 Identities = 156/388 (40%), Positives = 218/388 (56%), Gaps = 59/388 (15%)

Query: 79  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYEL---------------- 122
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 123 --GEEAMEKFREDE--GFIKEEERPLPEKEY---------------------QRQVWLLF 157
              EEA++ F   +  G    ++  L  K                       Q ++W LF
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219

Query: 158 EYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIF 217
           E P SS  AR IA  S+  IL+SI  FCLET       K+ T  V  I+ T+V+    I 
Sbjct: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV--INGTSVVLQYEIE 277

Query: 218 TDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ 276
           TDP    VE +C++WF+FE +VR    P+K +F KN++N ID VAI+P+++ +G      
Sbjct: 278 TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLS---- 333

Query: 277 EGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 336
            G         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +G
Sbjct: 334 -GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392

Query: 337 VILFSSAVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKI 387
           V++F++ +Y+AE   A+         + F +IP  FWWAVV+MTT+GYGDMYP T  G +
Sbjct: 393 VLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 452

Query: 388 VGSLCAIAGVLTIALPVPVIVSNFNYFY 415
           VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 453 VGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  258 bits (658), Expect = 1e-68
 Identities = 149/402 (37%), Positives = 238/402 (59%), Gaps = 38/402 (9%)

Query: 39  VVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQS 98
           +V+N+SG RF+T   TL ++P+TLLG+ ++   ++ P   +YFFDR+   F  IL +Y++
Sbjct: 43  IVLNVSGTRFQTWQDTLERYPDTLLGSSERDF-FYHPETQQYFFDRDPDIFRHILNFYRT 101

Query: 99  GGRLRRPVNVPLDMFSEEIKFYEL---------GEEAMEKFREDEGFIKEE-------ER 142
           G +L  P +  +  + EE+ F+ L          EE  ++ RE+   ++++       E 
Sbjct: 102 G-KLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160

Query: 143 PLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTV 202
            LP    +++VW  FE P +S  A V   V+   I +S++   +ET+P         G +
Sbjct: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP----CGSSPGHI 216

Query: 203 HRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAI 262
             +           +   FF ++T C++ F+ E ++R  A PS+  F +++M+ ID+VAI
Sbjct: 217 KELPC------GERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAI 270

Query: 263 IPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKAS 322
           +PY+I L   +     +  G   T       +R+ RVFRIFK SRHS+GL+ILG TLK+ 
Sbjct: 271 LPYYIGL---VMTDNEDVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYTLKSC 320

Query: 323 MRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382
             ELG L+F L + +I+F++ +++AE   + S F+SIP AFW+ +V+MTT+GYGDM P T
Sbjct: 321 ASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKT 380

Query: 383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424
           I GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 381 IAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 422


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  242 bits (617), Expect = 6e-64
 Identities = 133/292 (45%), Positives = 180/292 (61%), Gaps = 38/292 (13%)

Query: 147 KEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRID 206
           + +Q +VW LFE P SS  AR +A  S+  ILISI  FCLET           G +H I 
Sbjct: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLET---------HEGFIH-IS 319

Query: 207 NTTV-------------IYNSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKN 252
           N TV             I N  + T+PF   VE +C++WF+FE ++R   CP K +F K+
Sbjct: 320 NKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKS 379

Query: 253 IMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGL 312
            +N ID VAI+P+++ +G       G         L  LRV+R VR+ RIFKL+RH  GL
Sbjct: 380 SLNIIDCVAILPFYLEVGLS-----GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL 434

Query: 313 QILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAE---------SHFSSIPDAF 363
           ++LG TL+AS  E  LLI FL +GV++F++ +Y+AE   A+         ++F +IP  F
Sbjct: 435 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGF 494

Query: 364 WWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 415
           WWAVV+MTT+GYGDMYP T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 495 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 35/95 (36%), Positives = 55/95 (57%), Gaps = 5/95 (5%)

Query: 38  RVVINISGLRFETQLKTLAQFPNTLLGN---PKKRMRY-FDPLRNEYFFDRNRPSFDAIL 93
           ++VIN+ G+R ET   TL   P T L     P+   R+ +DP  +E+FFDR+   F  +L
Sbjct: 89  KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVL 148

Query: 94  YYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME 128
            YY++ G+L  P +V   +F EE+ F+ + E  +E
Sbjct: 149 NYYRT-GKLHCPADVCGPLFEEELGFWGIDETDVE 182


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  235 bits (600), Expect = 6e-62
 Identities = 147/462 (31%), Positives = 244/462 (52%), Gaps = 61/462 (13%)

Query: 2   TVMSGENVDE-ASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 60
           T + G + +   S  PG P  G   R++D       E + +N+ G+R +   + LA+FP 
Sbjct: 22  TPLGGRSTETFVSEFPG-PDTGIRWRRSD-------EALRVNVGGVRRQLSARALARFPG 73

Query: 61  TLLGN---------PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLD 111
           T LG           ++    +D    E++FDR+   F ++L++Y++G  L     + + 
Sbjct: 74  TRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTG-HLHVLDELCVF 132

Query: 112 MFSEEIKFYELGEEAM----------EKFREDEGFIKEEERP-----LPEK--------- 147
            F +E  ++ LGE A+           +  +   + ++ + P      P++         
Sbjct: 133 AFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELA 192

Query: 148 --------EYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFT 199
                     +R++WL  E P  S P+++ + VS+ V+L SI   C+ +LPE +  +   
Sbjct: 193 RYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAA 252

Query: 200 GTVHRIDNTTVIYNSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFID 258
                    +      +  DP    +E  CI WFSFE+  R    PS  +FF + +N ID
Sbjct: 253 AVAAVAAGRSP---EGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLID 309

Query: 259 IVAIIPYFITL--GTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILG 316
           IV+++P+++TL  G  + +Q G + G       +++V RL+R+FR+ KL+RHS GL+ LG
Sbjct: 310 IVSVLPFYLTLLAGVALGDQGGKEFGHLGK---VVQVFRLMRIFRVLKLARHSTGLRSLG 366

Query: 317 QTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYG 376
            TLK S RE+G+L+ +L +GV +FS   Y AE EE +  F++IP  +WW  VSMTTVGYG
Sbjct: 367 ATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEE-DVGFNTIPACWWWGTVSMTTVGYG 425

Query: 377 DMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 418
           D+ PVT+ GK+  S C + G+L +ALP+ +I + F++FY R+
Sbjct: 426 DVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQ 467


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  234 bits (596), Expect = 2e-61
 Identities = 150/452 (33%), Positives = 243/452 (53%), Gaps = 65/452 (14%)

Query: 19  PQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRY------ 72
           P+ GS    A  DD E    +V+N+ G+R       L+Q+P T L      +        
Sbjct: 10  PEPGSQSSAAS-DDIE----IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIF 64

Query: 73  -----FDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPL------DMFSEEIKFYE 121
                +DP + E++FDR+  +F  ++  Y  G    +    P+      D +  ++KF +
Sbjct: 65  SLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLD 124

Query: 122 --LGEEAMEKFREDEGFIKEEERPLPE----------KEYQRQVWLLFEYPESSGPARVI 169
                   EK  E E   +  +  L +          +  Q+ VW   E PESS PARV+
Sbjct: 125 DCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVV 184

Query: 170 AIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCI 229
           A++S ++IL+S V+ C+ T+PEL+   D  G  +R+++ T+             VET CI
Sbjct: 185 AVLSFLLILVSSVVMCMGTIPELQV-LDAEG--NRVEHPTLEN-----------VETACI 230

Query: 230 IWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITL-----GTEIAEQEGNQKGEQ 284
            WF+ E ++R F+ P+K  F  + MN +D++AI+P++++L     G  + E    Q+  Q
Sbjct: 231 GWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQ 290

Query: 285 ATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAV 344
           A        +R++R+ RIFKL+RHS GLQ L   LK S +ELGLL+ +L +G+ +FS+  
Sbjct: 291 A--------LRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALG 342

Query: 345 YFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPV 404
           Y  E    E+ F SIP +FWWA+++MTTVGYGD+YP T  GK+  ++  + GV+ IALP+
Sbjct: 343 YTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPI 402

Query: 405 PVIVSNFNYFYHR----ETEGEEQAQLLHVSS 432
             I++NF  +Y++    ET  + + +L+ ++S
Sbjct: 403 HPIINNFVRYYNKQRVLETAAKHELELMELNS 434


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  233 bits (593), Expect = 4e-61
 Identities = 155/478 (32%), Positives = 241/478 (50%), Gaps = 89/478 (18%)

Query: 41  INISGLRFETQLKTLAQFPNTLLGNPK---------KRMRYFDPLRNEYFFDRNRPSFDA 91
           IN+ G +   +  TL +FP T LG            +    +D ++ E++FDRN   F  
Sbjct: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80

Query: 92  ILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGE--------------------------- 124
           +L++Y +G +L     + +  FS+EI+++ + E                           
Sbjct: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139

Query: 125 ---EAMEKFREDEGFIKEEER--PLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILI 179
                   F E   F  +  +    P   ++RQ+WL  + P  S  +RV +I+S++V++ 
Sbjct: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199

Query: 180 SIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFF-IVETLCIIWFSFELVV 238
           SI+  CL +LP+ +                     N   DP F IVE   I WF+FELV 
Sbjct: 200 SIITMCLNSLPDFQIPDS---------------QGNPGEDPRFEIVEHFGIAWFTFELVA 244

Query: 239 RFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA----ILRVI 294
           RF   P    FFKN +N ID+++I+P++ITL   +         E   +LA    + +V+
Sbjct: 245 RFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV-------ESTPTLANLGRVAQVL 297

Query: 295 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 354
           RL+R+FRI KL+RHS GL+ LG TLK S +E+GLL+ +L +G+ +FS   Y  E EE E 
Sbjct: 298 RLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG 357

Query: 355 HFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 414
             ++IP  +WWA VSMTTVGYGD+ P T  GK+  S C +AG+L + LP+ +I + F++F
Sbjct: 358 -LATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHF 416

Query: 415 YHRETEGEEQAQ-------LLHVSSPNL------------ASDSDLSRRSSSTMSKSE 453
           Y R+ + E   +       +  V S NL            AS +++SR S S +S ++
Sbjct: 417 YRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLND 474


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  230 bits (587), Expect = 2e-60
 Identities = 156/500 (31%), Positives = 251/500 (50%), Gaps = 71/500 (14%)

Query: 37  ERVVINISGLRFETQLKTLAQFPNTLLG------NPKKRMRYFDPLR---NEYFFDRNRP 87
           E V +N+ G +      TL +FP+T LG      + +  +   D       EY+FDRN  
Sbjct: 15  ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPS 74

Query: 88  SFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF-------REDEGFIKE- 139
            F  +L +Y +G +L     + +  F +EI+++ + E  ++         R++E   K+ 
Sbjct: 75  LFRYVLNFYYTG-KLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDW 133

Query: 140 -------------EERPLPEKEYQR-----------QVWLLFEYPESSGPARVIAIVSVM 175
                        EE  L EKE ++           ++W+  E P     A++IAI S+ 
Sbjct: 134 DQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLS 193

Query: 176 VILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFI-VETLCIIWFSF 234
           V+L SIV  C+ ++ E +++         +D            DP    VE  CI WF+ 
Sbjct: 194 VVLASIVAMCVHSMSEFQNEDG------EVD------------DPVLEGVEIACIAWFTG 235

Query: 235 ELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVI 294
           EL VR  A P +  F+KN +N ID V+IIP++ TL  +  E+E            +++++
Sbjct: 236 ELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGK---VVQIL 292

Query: 295 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 354
           RL+R+FRI KL+RHS GL+ LG TL+ S  E+GLL+ FL +G+ +FS  +Y  E ++  S
Sbjct: 293 RLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTS 352

Query: 355 HFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 414
             +SIP  +WWA +SMTTVGYGD +PVT+ GK++ S C I G+L +ALP+ +I + F+ +
Sbjct: 353 SLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKY 412

Query: 415 YHRETE------GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHY 468
           Y ++ +       E+  +  H        D    R  +   S S    +  D +++ A  
Sbjct: 413 YQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASS 472

Query: 469 RQVNIRTANCTTANQNCVNK 488
            + N    N TT+ +NC  K
Sbjct: 473 IEDNEDICN-TTSLENCTAK 491


>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
           isoform 1 [Homo sapiens]
          Length = 436

 Score =  224 bits (570), Expect = 2e-58
 Identities = 137/414 (33%), Positives = 223/414 (53%), Gaps = 43/414 (10%)

Query: 39  VVINISGLRFETQLKTLAQFP----NTLLGNPKKR-----MRYFDPLRNEYFFDRNRPSF 89
           VV+N+ G R+    + L  FP    + L G   +R        +D  RNEYFFDR+  +F
Sbjct: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70

Query: 90  DAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEK----------------FRED 133
             IL Y +  G+LR    +    F  E+ ++ L    +E                 +  D
Sbjct: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130

Query: 134 EGFI--KEEERP-----LPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCL 186
           E  +  ++E RP      P + +  ++   FE P SS  A+++A VSV+ +++S+V+ C 
Sbjct: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190

Query: 187 ETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSK 246
            TLP+ ++        +R  +    Y++    +P  I+E +CI WF+ E +VRF    +K
Sbjct: 191 STLPDWRN----AAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNK 246

Query: 247 TDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLS 306
            +F K  +N ID++AI PY+I++   +   E +Q      +L   RV+R++R+F + KL+
Sbjct: 247 CEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTL---RVLRMMRIFWVIKLA 303

Query: 307 RHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE----AEEAESHFSSIPDA 362
           RH  GLQ LG TLK   RE+ +L+ F+ + + +FS+     E     E +   F+SIP A
Sbjct: 304 RHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAA 363

Query: 363 FWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 416
            WW ++SMTTVGYGDMYP+T+ G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 364 CWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417


>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
           isoform 2 [Homo sapiens]
          Length = 425

 Score =  219 bits (558), Expect = 4e-57
 Identities = 137/414 (33%), Positives = 220/414 (53%), Gaps = 54/414 (13%)

Query: 39  VVINISGLRFETQLKTLAQFP----NTLLGNPKKR-----MRYFDPLRNEYFFDRNRPSF 89
           VV+N+ G R+    + L  FP    + L G   +R        +D  RNEYFFDR+  +F
Sbjct: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70

Query: 90  DAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEK----------------FRED 133
             IL Y +  G+LR    +    F  E+ ++ L    +E                 +  D
Sbjct: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130

Query: 134 EGFI--KEEERP-----LPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCL 186
           E  +  ++E RP      P + +  ++   FE P SS  A+++A VSV+ +++S+V+ C 
Sbjct: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190

Query: 187 ETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSK 246
            TLP+ ++           DN ++   S I       +E +CI WF+ E +VRF    +K
Sbjct: 191 STLPDWRNAA--------ADNRSLDDRSRI-------IEAICIGWFTAECIVRFIVSKNK 235

Query: 247 TDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLS 306
            +F K  +N ID++AI PY+I++   +   E +Q      +L   RV+R++R+F + KL+
Sbjct: 236 CEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTL---RVLRMMRIFWVIKLA 292

Query: 307 RHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE----AEEAESHFSSIPDA 362
           RH  GLQ LG TLK   RE+ +L+ F+ + + +FS+     E     E +   F+SIP A
Sbjct: 293 RHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAA 352

Query: 363 FWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 416
            WW ++SMTTVGYGDMYP+T+ G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 353 CWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 406


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  216 bits (550), Expect = 4e-56
 Identities = 141/448 (31%), Positives = 235/448 (52%), Gaps = 71/448 (15%)

Query: 41  INISGLRFETQLKTLAQFPNTLLG-------------------NPKKRMRYFDPLRNEYF 81
           +N+ G RF    + L+ FP+T LG                   +P +     +P+ NEYF
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102

Query: 82  FDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEE- 140
           FDR+  +F  +L+YY++G RL     +    F +EI+++ + E +++    D  F ++E 
Sbjct: 103 FDRSSQAFRYVLHYYRTG-RLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKEL 161

Query: 141 ------ERPLPEKEYQRQ----------------VWLLFEYPESSGPARVIAIVSVMVIL 178
                 ++   ++E Q +                +W + E P SS  AR+  ++S++ ++
Sbjct: 162 SETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVV 221

Query: 179 ISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVV 238
           +SI+   L +  EL                     S +      I+E +CI WF+ E V+
Sbjct: 222 VSIINMALMSA-EL---------------------SWLDLQLLEILEYVCISWFTGEFVL 259

Query: 239 RFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA-ILRVIRLV 297
           RF     +  F + + N ID++AI+P++ITL  E     G+Q  ++  ++  I++V+RL+
Sbjct: 260 RFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVE--SLSGSQTTQELENVGRIVQVLRLL 317

Query: 298 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFS 357
           R  R+ KL RHS GL+ LG T+     E+GLL+ FL +G+ +FS+  YFAE    ++ F+
Sbjct: 318 RALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFT 377

Query: 358 SIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFN--YFY 415
           S+P A+WWA  SMTTVGYGD+ P T  GKIV  +C ++G+L +ALP+ +I   F+  YF 
Sbjct: 378 SVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFT 437

Query: 416 HRETEGE-EQAQLLHVSSPNLASDSDLS 442
            +  E    Q + L   + N+A+DS +S
Sbjct: 438 LKLKEAAVRQREALKKLTKNIATDSYIS 465


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,776,633
Number of Sequences: 37866
Number of extensions: 777351
Number of successful extensions: 2954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 150
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2392
Number of HSP's gapped (non-prelim): 396
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.