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Search of human proteins with 118918407
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118918407 spectrin repeat containing, nuclear envelope 2
isoform 5 [Homo sapiens]
(6907 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 1.358e+04 0.0
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 1.352e+04 0.0
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 2278 0.0
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 2248 0.0
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 1956 0.0
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo... 1077 0.0
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof... 965 0.0
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo... 814 0.0
gi|221316624 dystonin isoform 4 [Homo sapiens] 234 3e-60
gi|221316622 dystonin isoform 3 [Homo sapiens] 234 3e-60
gi|221316618 dystonin isoform 2 [Homo sapiens] 234 3e-60
gi|34577047 dystonin isoform 1 [Homo sapiens] 234 3e-60
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 234 3e-60
gi|19923599 calmin [Homo sapiens] 224 3e-57
gi|110611228 utrophin [Homo sapiens] 223 5e-57
gi|33188445 microfilament and actin filament cross-linker protei... 212 1e-53
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 206 6e-52
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 204 2e-51
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 204 2e-51
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 204 2e-51
gi|33188443 microfilament and actin filament cross-linker protei... 203 4e-51
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 203 4e-51
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 203 4e-51
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 203 4e-51
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 203 4e-51
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 202 7e-51
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 202 1e-50
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 200 5e-50
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 198 2e-49
gi|67782321 spectrin beta isoform a [Homo sapiens] 197 3e-49
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 1.358e+04 bits (35246), Expect = 0.0
Identities = 6907/6907 (100%), Positives = 6907/6907 (100%)
Query: 1 MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD
Sbjct: 1 MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
Query: 61 IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN
Sbjct: 61 IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
Query: 121 PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ
Sbjct: 121 PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
Query: 181 MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD
Sbjct: 181 MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
Query: 241 NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300
NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK
Sbjct: 241 NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300
Query: 301 DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360
DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD
Sbjct: 301 DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360
Query: 361 KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420
KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV
Sbjct: 361 KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420
Query: 421 TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480
TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL
Sbjct: 421 TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480
Query: 481 LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
Sbjct: 481 LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540
Query: 541 KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600
KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA
Sbjct: 541 KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600
Query: 601 CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660
CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK
Sbjct: 601 CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660
Query: 661 LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720
LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE
Sbjct: 661 LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720
Query: 721 KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780
KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF
Sbjct: 721 KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780
Query: 781 DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840
DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV
Sbjct: 781 DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840
Query: 841 SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV
Sbjct: 841 SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
Query: 901 EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960
EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI
Sbjct: 901 EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960
Query: 961 NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK
Sbjct: 961 NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
Query: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE
Sbjct: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
Query: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140
KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD
Sbjct: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140
Query: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200
FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK
Sbjct: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200
Query: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260
ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH
Sbjct: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260
Query: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320
LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED
Sbjct: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320
Query: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380
TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC
Sbjct: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380
Query: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440
LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL
Sbjct: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440
Query: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500
KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG
Sbjct: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500
Query: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560
REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL
Sbjct: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560
Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA
Sbjct: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE
Sbjct: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740
RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC
Sbjct: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740
Query: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800
HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL
Sbjct: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800
Query: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860
ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE
Sbjct: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860
Query: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920
CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ
Sbjct: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920
Query: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980
EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC
Sbjct: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980
Query: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040
QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP
Sbjct: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040
Query: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100
TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI
Sbjct: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100
Query: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE
Sbjct: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
Query: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220
LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE
Sbjct: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220
Query: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280
EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV
Sbjct: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280
Query: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340
DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK
Sbjct: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340
Query: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400
DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE
Sbjct: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400
Query: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460
EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK
Sbjct: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460
Query: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC
Sbjct: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
Query: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK
Sbjct: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
Query: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI
Sbjct: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK
Sbjct: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760
NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD
Sbjct: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760
Query: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL
Sbjct: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS
Sbjct: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
Query: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940
QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH
Sbjct: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940
Query: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000
KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK
Sbjct: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000
Query: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL
Sbjct: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
Query: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180
LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL
Sbjct: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180
Query: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL
Sbjct: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
Query: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300
NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ
Sbjct: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300
Query: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN
Sbjct: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
Query: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL
Sbjct: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
Query: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480
RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER
Sbjct: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480
Query: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN
Sbjct: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
Query: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600
VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ
Sbjct: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600
Query: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660
QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ
Sbjct: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660
Query: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ
Sbjct: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL
Sbjct: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900
LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK
Sbjct: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900
Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG
Sbjct: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS
Sbjct: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
Query: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080
LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER
Sbjct: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080
Query: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140
DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW
Sbjct: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140
Query: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200
SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ
Sbjct: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200
Query: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE
Sbjct: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
Query: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK
Sbjct: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
Query: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
Query: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
Query: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
Query: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
Query: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
Query: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680
AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV
Sbjct: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680
Query: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740
ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ
Sbjct: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740
Query: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800
DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI
Sbjct: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800
Query: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860
LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST
Sbjct: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860
Query: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920
LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK
Sbjct: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920
Query: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980
LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD
Sbjct: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980
Query: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040
LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML
Sbjct: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040
Query: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100
ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK
Sbjct: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100
Query: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160
HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR
Sbjct: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160
Query: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220
KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA
Sbjct: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220
Query: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK
Sbjct: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
Query: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV
Sbjct: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR
Sbjct: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460
LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA
Sbjct: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460
Query: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520
ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL
Sbjct: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520
Query: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580
DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA
Sbjct: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580
Query: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640
TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE
Sbjct: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640
Query: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700
VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR
Sbjct: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700
Query: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL
Sbjct: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880
ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL
Sbjct: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880
Query: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940
VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV
Sbjct: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940
Query: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN
Sbjct: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
Query: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ
Sbjct: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
Query: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120
KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI
Sbjct: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120
Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE
Sbjct: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
Query: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240
AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL
Sbjct: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240
Query: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300
RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI
Sbjct: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300
Query: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360
DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA
Sbjct: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360
Query: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420
SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD
Sbjct: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420
Query: 6421 HTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 6480
HTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP
Sbjct: 6421 HTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 6480
Query: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6540
DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE
Sbjct: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6540
Query: 6541 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6600
DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML
Sbjct: 6541 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6600
Query: 6601 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660
KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ
Sbjct: 6601 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660
Query: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720
LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR
Sbjct: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720
Query: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR
Sbjct: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
Query: 6781 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRV 6840
EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRV
Sbjct: 6781 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRV 6840
Query: 6841 PGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRY 6900
PGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRY
Sbjct: 6841 PGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRY 6900
Query: 6901 TNGPPPT 6907
TNGPPPT
Sbjct: 6901 TNGPPPT 6907
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 1.352e+04 bits (35085), Expect = 0.0
Identities = 6884/6908 (99%), Positives = 6884/6908 (99%), Gaps = 24/6908 (0%)
Query: 1 MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD
Sbjct: 1 MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
Query: 61 IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN
Sbjct: 61 IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
Query: 121 PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ
Sbjct: 121 PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
Query: 181 MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD
Sbjct: 181 MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
Query: 241 NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300
NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK
Sbjct: 241 NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300
Query: 301 DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360
DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD
Sbjct: 301 DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360
Query: 361 KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420
KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV
Sbjct: 361 KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420
Query: 421 TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480
TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL
Sbjct: 421 TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480
Query: 481 LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
Sbjct: 481 LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540
Query: 541 KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600
KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA
Sbjct: 541 KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600
Query: 601 CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660
CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK
Sbjct: 601 CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660
Query: 661 LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720
LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE
Sbjct: 661 LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720
Query: 721 KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780
KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF
Sbjct: 721 KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780
Query: 781 DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840
DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV
Sbjct: 781 DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840
Query: 841 SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV
Sbjct: 841 SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
Query: 901 EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960
EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI
Sbjct: 901 EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960
Query: 961 NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK
Sbjct: 961 NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
Query: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE
Sbjct: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
Query: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140
KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD
Sbjct: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140
Query: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200
FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK
Sbjct: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200
Query: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260
ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH
Sbjct: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260
Query: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320
LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED
Sbjct: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320
Query: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380
TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC
Sbjct: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380
Query: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440
LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL
Sbjct: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440
Query: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500
KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG
Sbjct: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500
Query: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560
REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL
Sbjct: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560
Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA
Sbjct: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE
Sbjct: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740
RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC
Sbjct: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740
Query: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800
HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL
Sbjct: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800
Query: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860
ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE
Sbjct: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860
Query: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920
CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ
Sbjct: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920
Query: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980
EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC
Sbjct: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980
Query: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040
QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP
Sbjct: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040
Query: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100
TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI
Sbjct: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100
Query: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE
Sbjct: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
Query: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220
LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE
Sbjct: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220
Query: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280
EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV
Sbjct: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280
Query: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340
DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK
Sbjct: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340
Query: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400
DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE
Sbjct: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400
Query: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460
EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK
Sbjct: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460
Query: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC
Sbjct: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
Query: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK
Sbjct: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
Query: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI
Sbjct: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK
Sbjct: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760
NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD
Sbjct: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760
Query: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL
Sbjct: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS
Sbjct: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
Query: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940
QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH
Sbjct: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940
Query: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000
KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK
Sbjct: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000
Query: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL
Sbjct: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
Query: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180
LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL
Sbjct: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180
Query: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL
Sbjct: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
Query: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300
NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ
Sbjct: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300
Query: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN
Sbjct: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
Query: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL
Sbjct: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
Query: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480
RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER
Sbjct: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480
Query: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN
Sbjct: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
Query: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600
VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ
Sbjct: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600
Query: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660
QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ
Sbjct: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660
Query: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ
Sbjct: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL
Sbjct: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900
LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK
Sbjct: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900
Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG
Sbjct: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS
Sbjct: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
Query: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080
LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER
Sbjct: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080
Query: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140
DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW
Sbjct: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140
Query: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200
SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ
Sbjct: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200
Query: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE
Sbjct: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
Query: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK
Sbjct: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
Query: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
Query: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
Query: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
Query: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
Query: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
Query: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680
AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV
Sbjct: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680
Query: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740
ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ
Sbjct: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740
Query: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800
DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI
Sbjct: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800
Query: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860
LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST
Sbjct: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860
Query: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920
LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK
Sbjct: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920
Query: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980
LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD
Sbjct: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980
Query: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040
LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML
Sbjct: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040
Query: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100
ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK
Sbjct: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100
Query: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160
HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR
Sbjct: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160
Query: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220
KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA
Sbjct: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220
Query: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK
Sbjct: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
Query: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV
Sbjct: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR
Sbjct: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460
LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA
Sbjct: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460
Query: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520
ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL
Sbjct: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520
Query: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580
DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA
Sbjct: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580
Query: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640
TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE
Sbjct: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640
Query: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700
VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR
Sbjct: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700
Query: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL
Sbjct: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880
ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL
Sbjct: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880
Query: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940
VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV
Sbjct: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940
Query: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN
Sbjct: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
Query: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ
Sbjct: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
Query: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120
KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI
Sbjct: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120
Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE
Sbjct: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
Query: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240
AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL
Sbjct: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240
Query: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300
RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI
Sbjct: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300
Query: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360
DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA
Sbjct: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360
Query: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420
SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD
Sbjct: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420
Query: 6421 HTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 6480
HTGDVGGSSSHEEDEEGPYYSAL SGKSISDGHSWHVP
Sbjct: 6421 HTGDVGGSSSHEEDEEGPYYSAL-----------------------SGKSISDGHSWHVP 6457
Query: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6540
DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE
Sbjct: 6458 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6517
Query: 6541 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6600
DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML
Sbjct: 6518 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6577
Query: 6601 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660
KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ
Sbjct: 6578 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
Query: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720
LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR
Sbjct: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6697
Query: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR
Sbjct: 6698 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6757
Query: 6781 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTEGEEETESR 6839
EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTEGEEETESR
Sbjct: 6758 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESR 6817
Query: 6840 VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLR 6899
VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLR
Sbjct: 6818 VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLR 6877
Query: 6900 YTNGPPPT 6907
YTNGPPPT
Sbjct: 6878 YTNGPPPT 6885
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 2278 bits (5902), Expect = 0.0
Identities = 1828/6565 (27%), Positives = 3144/6565 (47%), Gaps = 553/6565 (8%)
Query: 733 LKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDT-----------SMEESLKHLIAKGSMFD 781
LK KD++K E+ ++ Q+++++ S+ ++ LI K
Sbjct: 2346 LKKVKDIQK-----ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400
Query: 782 ELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVS 841
+L ++++ LQ ++ S ES Q L AK AA K +D +
Sbjct: 2401 QLCSKTQASLQESLEKHFS-ESMQEFQEWFLGAK----------------AAAKESSDRT 2443
Query: 842 PDLDI-RLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
D + K+ + Q L+S + Q L G+ + H I+S+ + + KA
Sbjct: 2444 GDSKVLEAKLHDLQNILDS-VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE--QITKAN 2500
Query: 901 EELKNNVTEDIKMSLEEKSRDVCAK----WESLHHELSLYVQQLKIDIEKGKLSDNILKL 956
EE + + + +K ++++ CA +E H +L+L++ +++ L ++ +
Sbjct: 2501 EEFQAFLKQCLK---DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHI 2557
Query: 957 EKQINKEKK-------LIRRGRTKGLIKEHEACFSEEG---------CLYQLNHHMEVLR 1000
++ N+ K L+ + + + SEEG C L H +LR
Sbjct: 2558 PEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLR 2617
Query: 1001 ELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTS------------ 1048
E+L S + + L++ Q + +K + + T G
Sbjct: 2618 MTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDI 2677
Query: 1049 ---KNEGTITTSENRGGDPHSEAPFAKSDN---QPSTEKAMEPTMKFSLASVLRPLQEES 1102
K EG + + G + K Q E E +SV ES
Sbjct: 2678 LLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES 2737
Query: 1103 IMEK--DYSASINSLLERYDTYRDILEHHLQ-----NNKF----RITSDFSSEEDRSSSC 1151
++ + DY N L + ++ +EH LQ KF + S S ED + +
Sbjct: 2738 VISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL 2797
Query: 1152 LQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLN 1211
+ ++ + D +K+ LK + NDI KE+ R+++ +
Sbjct: 2798 HRLIAKSRELYEKTEDESFKDTAQEELKTQ--FNDIMT--------VAKEKMRKVEEIVK 2847
Query: 1212 TRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQ 1271
+ L+ V + + L + LH+ + + ++ + DS
Sbjct: 2848 DHLMYLDA-------VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIG 2900
Query: 1272 IEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLAS 1331
+R+E V + M + + ++ V +++ L+ L +A
Sbjct: 2901 ASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA- 2959
Query: 1332 LRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD------KCLKMLD 1385
LS + + A Q ++ + +K ++ L++ K + K ++LD
Sbjct: 2960 -----LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILD 3014
Query: 1386 MSFKDAERGDDTSCE-NLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQ 1444
K R +D + N L FS LS T+ V E N L C+ + Q
Sbjct: 3015 ALQKAEPRTEDLKSQLNELCRFSRDLS-TYSGKVSGLIKEYNCL---CLQASKGCQNKEQ 3070
Query: 1445 DVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT 1504
+Q + K A + ++ L+ + + +++ E++ SL ++ ++
Sbjct: 3071 ILQQRFRK---------AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3121
Query: 1505 VNQQCQNTVVLWENTKALVTECLEQC-GRVLELLKQYQNFKSILTTLIQKEESVISLQAS 1563
N Q + ++L + E+ G ++ +++K+ + L QKE ++
Sbjct: 3122 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESAL------ 3175
Query: 1564 YMGKENLKKRIAEIEIVKEEFNEHLEVVDK---------------------INQVCKNLQ 1602
ENLK ++ + E+ E + L +K + V + +
Sbjct: 3176 ----ENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIH 3231
Query: 1603 FY---LNKMKTFEEPPFEKEA---------NIIVDRWLDINEKTEDYYENLGRALALWDK 1650
Y LN++K + +E +A + + ++L ++ T++ L R +A ++
Sbjct: 3232 CYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQ 3291
Query: 1651 LFNLKNVIDEWTEKALQKMELHQLTEEDRE-------RLKEELQVHEQKTSEFSRRVAEI 1703
+ +W A+ ++ + D+ +L+ L V ++K + V
Sbjct: 3292 FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRG 3351
Query: 1704 QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA-LSGSTAELREDLDQAKTQIG 1762
+ +LQ++ P + ++ + + + L+ C + L G+ ++ D + G
Sbjct: 3352 ESVLQNTS-PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3410
Query: 1763 MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS 1822
+S+ L+ S E Q L+ K +M+ L+E Y S+
Sbjct: 3411 WMDSMEANLNES----------ERQHAELRDKTTMLGKAKL-------LNEEVLSYSSLL 3453
Query: 1823 DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQ------ 1876
+ K + + +H+ L + ++ + + I+ KE SE + Q+ Q
Sbjct: 3454 ETIEVKGAGMTEHYVTQL--ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAF 3511
Query: 1877 ---------KLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKM 1927
KL + LEG + L+ ++ H + L S L +E +
Sbjct: 3512 EVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL-LNSVLHTREDVIPS- 3569
Query: 1928 ESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKR 1987
I QA + LE Q Q R N K + ME+ ++ + + + A ++
Sbjct: 3570 -GIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKT-AEEK 3627
Query: 1988 EQFESVAQLNNSLKEYGFTEEE---------EIIMEATCLMDRYQTLLRQLSE----IEE 2034
+ E V + ++E G +E + +AT L RYQ LL Q+ E +EE
Sbjct: 3628 KWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEE 3687
Query: 2035 EDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI-ILLKP-- 2091
E + L + S + + W ++ + + K+ +K+K + +LLK
Sbjct: 3688 EIQSLEESESSLSSYSD----WYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3743
Query: 2092 EGDARI-------ETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEG 2144
+G + + E +K E EA ++K + D Q EK L
Sbjct: 3744 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3803
Query: 2145 EKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKS 2204
+++ + L + E ++ + L EKKAQL YK + +K ++
Sbjct: 3804 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVRE 3863
Query: 2205 QGNYLLECTKNPSFSEE------PWLEIKHLHESLLQQL---QDSVQNLDGHVREHDSYQ 2255
+G LLE ++ + ++ + ++ + +++++++ +D + NL ++
Sbjct: 3864 KGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQ--MKGDTLIG 3921
Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIA--VEEKLQKLQ-ELENRLSLQDGTLKKILAL 2312
C L L + + I + Q L+ EL+ +S QD TL++ A
Sbjct: 3922 QCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQD-TLQQCQAW 3980
Query: 2313 AKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGK 2372
+V+ + Q + Q K A ++ C + + + T K
Sbjct: 3981 LSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAK-- 4038
Query: 2373 FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTED 2432
+ Q T E Q+ + L + WE K E+ + Q + ++MK
Sbjct: 4039 ------DIQQTEQTIE--QKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4090
Query: 2433 ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPL-EQTECLNKTETGALVL 2491
E ++N QN + +++ +L++K+A++ + E+ L K E
Sbjct: 4091 ELELNIAQNM------------VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHK 4138
Query: 2492 HNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
+ Q LD L + L +E RD+ + + VE ++ T+ ++L
Sbjct: 4139 EINHLNDQWLD-LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA 4197
Query: 2552 DSVT-YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQV 2610
+S +L+ +KK ++++ K ++ +LK + + + H+ DK+L++ Q LE W Q+
Sbjct: 4198 ESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL 4257
Query: 2611 EQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS--PEERAGNQSM--I 2666
E I++K V +E + ++ Q+ ++QQ ++ LK P + A N M +
Sbjct: 4258 EDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHL 4317
Query: 2667 ALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQ 2726
A+ ++L+A + L A+ M + G E++ ++ +++ + L L +
Sbjct: 4318 AICSELEAKQMLLKSLIKDADRVMADL-GLNERQVIQKALSDAQSHVNCLSDLVGQRRKY 4376
Query: 2727 IKKC-DIRNKMKETILWAKNLLGE------LNPSIPLLPDDILSQIRKCKVTHDGILARQ 2779
+ K + + + A + + + I LLPDD+ Q++ CK + Q
Sbjct: 4377 LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ 4436
Query: 2780 QSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNF 2839
V L + ++ + +T E S++ L++L++ Y ++ K + R Q+LE L R +F
Sbjct: 4437 NEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHF 4496
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELT 2899
K +++++ + P + +EL + ++ E ++ + T +
Sbjct: 4497 KEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQ 4556
Query: 2900 NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEA 2959
I LN + +L ++L L + N I ++ +V+ I +++ +
Sbjct: 4557 TILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSL 4616
Query: 2960 DSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKC-------CILQVLKLKKVFDYIGLNW 3012
++ L +++ EE +L+D AI + ++ + K+ F G W
Sbjct: 4617 SELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPW 4676
Query: 3013 DFSQLDQLQTQVFEKEKELEEKIKQLD----TFEEEHGKYQALLSKMRAIDLQIKKMTEV 3068
++ L T +++ E+++ L+ ++E Q L +++++ + K+ E
Sbjct: 4677 QPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE 4736
Query: 3069 VLKAPDSSPESRRLNAQILSQRI--EKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLN 3126
L A + L + I ++ +++ L D EK QI+
Sbjct: 4737 TLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHL------DPLAYEKARHQIQSW 4790
Query: 3127 AEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQ 3186
E L + V E + + + Q ++ SL L ++K++L P+ ++L ++ IQ
Sbjct: 4791 QGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQ 4850
Query: 3187 NEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE--ASDVETKLREFEDLQMQLNTSI 3244
E + QE+V + + + A++ EK++ + E ++D+E L E +L + ++
Sbjct: 4851 EEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL 4910
Query: 3245 DLRTNVLNDAYENLTRYKEAVTRAVESITSLEAII--IPYRVDVGNPEESLEMPLR---K 3299
R L + Y RY + A + + + ++ +DV + EE+L+ +
Sbjct: 4911 RTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFST 4970
Query: 3300 QEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLE 3359
+++ S + + L L + P K L+ + L ++ M AQ +R
Sbjct: 4971 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTA 5030
Query: 3360 NYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
+ Y+K E++ ++ E L + S EA E+L + KALVS + S E+++
Sbjct: 5031 QWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVA 5090
Query: 3420 LRQILRLLRLRCTENDG--ICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEE 3477
L + + +L T ND L + ++ +W++W L A++ E E+ EW + +
Sbjct: 5091 LEE--KASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
Query: 3478 IEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRS 3537
+++ ++D LQ++LP + E A+ EL LL+ + +E+QQ L +L Q+ S
Sbjct: 5149 VKKATEMIDQLQDKLP--GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLS 5206
Query: 3538 IQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKN 3597
+ + E P QEIT+M++RC + +KV+ N +LV+ E+++R +I ++K
Sbjct: 5207 MLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKC 5266
Query: 3598 FFQQTTTSFQNMAFQ----------------DHPEKSEQFEELQSILKKGKLTF------ 3635
+ Q+T N + +H + E+ E Q G T
Sbjct: 5267 WVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELS 5326
Query: 3636 -------------ENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKIS----NE 3678
+ I +K IK E E+ Q+++ K L I K+ N
Sbjct: 5327 LQLAEVALDLKIRDQIQDK--IKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNV 5384
Query: 3679 VLKSSPSYAMRRKIEEINNGLHN----VEKMLQQK-------SKNIEKAQEIQKKMWDEL 3727
V + + +++ N+ L V+K L+Q +K I K E+ ++ +
Sbjct: 5385 VQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQA 5444
Query: 3728 DLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKM 3787
+ SKLN+ S +++ E +W++ + + ++ R + T+ +
Sbjct: 5445 ENRLSKLNQAASHLEEYNEMLE-LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL-L 5502
Query: 3788 EEYSDLLKSTEAWIENTSHLLA-------NPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
EE ++ EA E +L + + + R +++ L++ +
Sbjct: 5503 EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD 5562
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQE-----LSNQVTALQQKI--MESL-PQIQ------ 3886
+ +L+ L E + T + E L Q++ Q + MESL P++Q
Sbjct: 5563 MKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ 5622
Query: 3887 ---RMADDVVA----------IESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVI 3933
R+ +DVVA ++ E ++ + I+ + + E+ +KH + +
Sbjct: 5623 SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQL 5682
Query: 3934 LE--------------NIRPMKKTIA-------EIVSYQVELRLPQTGMKPLPVFQRTNQ 3972
+E NI+ ++ I+ +I YQ ++ + K L + +
Sbjct: 5683 IEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT 5742
Query: 3973 LLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIEN--------LKQILNNYSAQFSLEHM 4024
+L + +E + + +L ++ + + L + + + +
Sbjct: 5743 MLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI 5802
Query: 4025 SPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLP 4084
S A + P + Q ++ Q L+ +H QE E P
Sbjct: 5803 SSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAAKIHPSTSASQEFYEPGLEP 5860
Query: 4085 AVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQ 4138
+ T++ G + + SE++ ++ ++ ++ S K + + K SP+
Sbjct: 5861 SATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE 5920
Query: 4139 SWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRP 4198
S + M E +A ++Q+ +I+ +S+A+ L +S + + +L+
Sbjct: 5921 PGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAEELVSESCEADPAEQLALQS 5974
Query: 4199 NQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQA 4255
T E +T ++A + L ++E+ R E + L + + EL+ WL
Sbjct: 5975 TLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--QALQRYRCEADELDSWLLST 6031
Query: 4256 NVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETC---KDQGLGDNGATQHEA 4312
++ +E QL+ CQ ML EIE KV L E ++ L T+ EA
Sbjct: 6032 KATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEA 6091
Query: 4313 EALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTE 4372
E L+ KL+ +K +L ++Q L +K Q K+ S+ + P L T
Sbjct: 6092 EQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTT 6151
Query: 4373 RPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASS 4432
Q RQ QQQ+ LE + EQK ++ + +++ Q+ + T+ ++ S
Sbjct: 6152 WTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAE--TSGDAGEKPDVLS 6208
Query: 4433 PENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQ----VSTNMGILPSVTMY 4488
E + S + Q KW+ LH E S+K KL L + Q S +L V +Y
Sbjct: 6209 QELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLY 6268
Query: 4489 NFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVE 4548
PT ++ T+ L+ L Q + +Q + I+L++KL++ S L VE
Sbjct: 6269 KGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVE 6327
Query: 4549 EMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECF 4607
E L + L E+ + E LA ++K++ + K +A G+N +++ +
Sbjct: 6328 ERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTL 6387
Query: 4608 DNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQS 4667
L L + R +K L ++QN++K L+ L +K + Q L + Q
Sbjct: 6388 GCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP 6447
Query: 4668 VAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARY 4727
VAEQ++ L+ ++ + +L+ G++L + +QE+ KL+D+ D + ++ +R
Sbjct: 6448 VAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRR 6507
Query: 4728 TELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV 4787
+ L+ +SQ + LQ + +L++ G+EK+A SK +Q ++ HK +FQ L
Sbjct: 6508 SGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE 6567
Query: 4788 ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENY 4847
+ M+L + KI+ +Q F E + + + +++ + G++L+ +L+ W DE+
Sbjct: 6568 SHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6627
Query: 4848 ASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA 4907
L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++ +LYQ L++GK+L+
Sbjct: 6628 QELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
Query: 4908 SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTL 4967
S+SC +LE Q+ +L E WLS K+ ELHRL+ +LKH Y +S L WL+S++ L
Sbjct: 6688 SISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL 6747
Query: 4968 NYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLR 5027
+W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V+S GNQLL LK+ DTATLR
Sbjct: 6748 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6807
Query: 5028 ASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS-DEDSVH 5086
+ L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E++SW++ +E+ DED++
Sbjct: 6808 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIK 6867
Query: 5087 SPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGE 5146
+ + LQK+K F+++++ KQ VDFVNQS+LQ+S+ DVESKR ++T+FAE LG
Sbjct: 6868 NSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGA 6927
Query: 5147 MNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQ 5206
MN+ W + G++ KIQ LE LLES +E EN +Q L W E QE+RLK + SVQ
Sbjct: 6928 MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQ 6987
Query: 5207 KLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLEDTASRIDELFQKRSSVLTQV 5265
L DCQD+E+ + K K +++++Q+ L L ++ + S + EL Q +++ V
Sbjct: 6988 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7047
Query: 5266 NQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQD 5325
QLK ++SVL +W + +D++N + Y + + + SLE ++ QV+NLQ+LQD
Sbjct: 7048 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQD 7107
Query: 5326 EAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLL 5384
+ E E S +K + +L C P V E + + + RW + + IA+QLQ +++LL
Sbjct: 7108 DLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL 7167
Query: 5385 QLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKE 5444
QLW+ Y + + A+ ++QQE + +L + + + + + +QD +L + K+
Sbjct: 7168 QLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKD 7227
Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFG 5503
+ + ++L Q ++S + SL Q LE+ L + + + ++ F
Sbjct: 7228 SLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFA 7287
Query: 5504 VRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNHVLALTAQSPDIEHLNEVSL 5556
LE+L+ I+ EE L D H + +E + +L ++ +PD++ LNE+
Sbjct: 7288 KSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGY 7347
Query: 5557 KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEA 5615
+LPL+D +K +QN+NR W ++ ER S+LQ L ++ FL CE W++ L + E+
Sbjct: 7348 RLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK 7407
Query: 5616 LKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFS 5675
L V+++ + LLEQQ+ +++ +AE+ Q I S + +LL+ ++++R EF + +
Sbjct: 7408 LAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLT 7467
Query: 5676 KLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLY 5735
L+++WQ ++ +QR+G +D +RQWQ + E L ++L + S+L + G L
Sbjct: 7468 LLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ 7527
Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
Q R+L E++ KE F R++ + LT+EAG++LLL+ D + ++ ++++Q+ WK
Sbjct: 7528 QARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSAS 7587
Query: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE 5855
+L E K+ ++ W++CEK I + +L+ K + LP+ HE+LH E+ KELE
Sbjct: 7588 MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7647
Query: 5856 QSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDR 5915
++ SWT +L +L +K L+ ++ +D+ +L E++E L RQWE+LC ++++R+Q+I +R
Sbjct: 7648 NAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGER 7707
Query: 5916 LNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQ 5975
LN W VF+EKNKELC WL QME+KV Q DI IEEMIEKL+KD EEI + ENK+QL+Q
Sbjct: 7708 LNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ 7767
Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
MG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET +QQLDKNMS+LR
Sbjct: 7768 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 7827
Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
TWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD D
Sbjct: 7828 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 7887
Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
ACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+
Sbjct: 7888 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 7947
Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRL 6215
ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A L
Sbjct: 7948 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8007
Query: 6216 KQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFS 6275
KQMVHEGNQRWDNLQ+RVT++LRRL+HF QREEFE R+SILVWLTEMDLQLTN+EHFS
Sbjct: 8008 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8067
Query: 6276 ESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
E D K++QL FQQEI+LN NKI+Q+I GEQLI+KSEPLDA +IE+EL+EL RYCQE
Sbjct: 8068 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8127
Query: 6336 VFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQ 6391
VFGRV R+H++L P +DE + S+ E ++ED + W R S +PSS
Sbjct: 8128 VFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 8186
Query: 6392 SLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG-------GSSSHEEDEEG----PYY 6440
SL ERSG +TP SVDSIPLEWDH D+ + EDEEG +Y
Sbjct: 8187 SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246
Query: 6441 ----SALSDVEIPENPEAYLKMTTKTLKASSG-KSISDGHSWHVPDSPSCPEHHYKQMEG 6495
LSDV IPE+PEAY+K+T +K +SG S + + + +Q E
Sbjct: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 8306
Query: 6496 -DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE----- 6549
R+ P P T YK G + L + + L ++E+ L G
Sbjct: 8307 IIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 8363
Query: 6550 -QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP 6605
Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I WL TE ELE L+ +
Sbjct: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8423
Query: 6606 PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 6665
+DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W
Sbjct: 8424 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 8483
Query: 6666 EAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 6725
+ ++ WRG L+ +LMQCQ FH++S LLL L + R+ + D D L +
Sbjct: 8484 DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 8543
Query: 6726 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS- 6784
++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI +LK L ++VS
Sbjct: 8544 HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 8603
Query: 6785 -----QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT-----------------SVPAPR 6821
+ L+ + +Q S S DE+D SG P + S P P
Sbjct: 8604 HIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPS 8663
Query: 6822 AKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEED 6881
R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+ LACL+P SEED
Sbjct: 8664 VSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEED 8723
Query: 6882 YSCTQANNFARSFYPMLRYTNGPPP 6906
YSC +NNFARSF+PMLRYTNGPPP
Sbjct: 8724 YSCALSNNFARSFHPMLRYTNGPPP 8748
Score = 597 bits (1538), Expect = e-169
Identities = 1215/5875 (20%), Positives = 2344/5875 (39%), Gaps = 933/5875 (15%)
Query: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
LQ EQE QK+ FT WINS LA+ P V+ DLF D+K G LL LLEVLSGQ+LP ++G
Sbjct: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
Query: 85 SNTFQCRI--NIEHALTFLRNRS-------IKLINIHVTDIIDGNPSIILGLIWTIILHF 135
+ NI AL FL R IKL+NI+ TDI DG PSI+LGL+WTIIL+F
Sbjct: 81 RRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYF 140
Query: 136 HIEKLAQTL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQ 194
IE+L L S V + SS SPP+K+ KV + Q +A+KALL W Q
Sbjct: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYT 198
Query: 195 CATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELK 254
+ V DF SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL
Sbjct: 199 AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 258
Query: 255 IPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK---- 310
IPRLL+PEDVDV PDEKSIMTYVAQFL++ D + Q + G+ +
Sbjct: 259 IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQN 318
Query: 311 ---------EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSI 352
++++ ++ E D KY S F + ++K ++
Sbjct: 319 FKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQP 378
Query: 353 KRDLDELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSA 412
+L D ++++WD + ++ W I+L+ +LP PL AWL E + E+++
Sbjct: 379 LHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITV 438
Query: 413 SQDHSQAVTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRIN 471
Q H + IQ K+ K L+ + H + + N +P VPP++LE+M R +
Sbjct: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFH 497
Query: 472 NI--LEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEK 529
+ + ++ +EF K +L L+ +SKL W IKYG RESVE LL+++ FIE
Sbjct: 498 FVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENS 557
Query: 530 EFLARLDTSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQK 583
+F + + ++Q + E+Y G + + +R + +V+S L++
Sbjct: 558 KFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEE 617
Query: 584 VLACWATYVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEV 638
V++ W Y + L+A E+ +K E K+ F L W +H +N+AGNFL+E
Sbjct: 618 VISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIET 677
Query: 639 SNDVVGSSISKELRRLNKRWRKLVSKTQ-------------------------------- 666
+++V + ++L LN RWR+L + +
Sbjct: 678 CDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKK 737
Query: 667 ----LE---MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQ 714
LE MN+ L+I+ +Q P D I++K + S E E +
Sbjct: 738 LSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFAT 795
Query: 715 NIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESL 770
K E+ K E ++ L + ++L+ +E E + S D +++ T +E
Sbjct: 796 MSKLKEQLTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREA 852
Query: 771 KHLIAKGSMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQ 824
+ EL+A E+ +++ Q++ + +VL Q ++Q +
Sbjct: 853 QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 912
Query: 825 I---NVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKH 881
+ ++VK K V + + K EES+ ELE + AQ+ L ++ P EL+ +H
Sbjct: 913 VAFQSMVKKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRH 970
Query: 882 KEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLK 941
E + + L +LKA +EL + + E + L+E R + +W+ L E ++ LK
Sbjct: 971 TEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1030
Query: 942 IDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRE 1001
ID+EK + ++ + ++++E KL+ + ++ +IKEH FS++G + ++++ E
Sbjct: 1031 IDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090
Query: 1002 LCEELPSQKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTS 1057
LC +LP + ++ LK+ I+ + E + S+ I+T+
Sbjct: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTN 1150
Query: 1058 ENRGGDPHSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIME 1105
E + EA + N ++A+E T+ + S VL + E+ +
Sbjct: 1151 ETQLKGIKGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ 1208
Query: 1106 K--DYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIK 1163
K D A ++S + T +E L N C+Q K +++K
Sbjct: 1209 KQGDELAKLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVK 1249
Query: 1164 NETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRL 1223
N + E+IS KE + + + L+T E+L A +L
Sbjct: 1250 NSLE------ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQL 1281
Query: 1224 VLPVEKASLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEP 1281
+L ++ + + + + Q DR ++ LR ++ ++ R E
Sbjct: 1282 LLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERR 1341
Query: 1282 GNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEP 1341
L++ F+ + + +++Y Q G +H S +L++L L + E
Sbjct: 1342 IQVTLRKWERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1398
Query: 1342 VTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCEN 1401
+ + + + A E L +NK+ L++ +AK + + +K L +DT E+
Sbjct: 1399 IAVQAENLVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEED 1444
Query: 1402 LLDAFSIKLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLK 1456
+ +K H +G E TE+ K L N L + + QIS+I +
Sbjct: 1445 IKTMEMVKTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV- 1495
Query: 1457 DPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLW 1516
T+ ++ + S++ L+E A S F E + + +
Sbjct: 1496 --TIQEIESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRY 1539
Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
+CLE G +L L Q Q F+ L + ++SV + + E
Sbjct: 1540 GEELREHAQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATE 1594
Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTED 1636
V +E + + ++ ++ F + K +EA + ++ DI + ++
Sbjct: 1595 TYKVLQEHMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1652
Query: 1637 YYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSE 1695
L LA W +L + W E+ K ++ DR +++ ELQ+ + +E
Sbjct: 1653 RQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE 1712
Query: 1696 FSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLD 1755
+ + LLQ E + + + K+ H+++ E DL
Sbjct: 1713 VVSQASFYSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLP 1757
Query: 1756 Q-AKTQIGMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSE 1813
Q +I +S++ D L + F+ ++ LQ + ++++Q+
Sbjct: 1758 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA-------- 1809
Query: 1814 LKKQYESVSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
L + + +++ + K + LQ H +KL D ++ ++CF+ E V
Sbjct: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQV 1866
Query: 1872 EQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESIC 1931
++ Q L + ++ H + + + V + K ES
Sbjct: 1867 VERRQLALSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES-- 1909
Query: 1932 QARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQF 1990
K+L D+LQ L+ +L L+ + K G E L + E+
Sbjct: 1910 DLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERI 1969
Query: 1991 ESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
+++ S E + + + D+ + LL+ + +IEE T+ + +
Sbjct: 1970 QNLLGTKQS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPT 2017
Query: 2051 HDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAP 2110
+ +++ L V N E ++ E E+ LK + + Q + + AP
Sbjct: 2018 R------QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAP 2061
Query: 2111 LVQKTLTDISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
V + + + WD+T L + + L K L++ + +
Sbjct: 2062 EVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT 2121
Query: 2161 LKKKQEAGFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPS 2217
+K +++ +A +H + K + K F K + L S LK++ S L++ +
Sbjct: 2122 IKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMEST 2181
Query: 2218 FSEEPWLEI-KHLHESL---------------------------LQQLQDSVQNLDGHVR 2249
+ WL++ + L E++ + Q+ +++ NLD H+R
Sbjct: 2182 V--DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLR 2239
Query: 2250 ----------EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRL 2299
E + + + +L++ +++ + + P Q + +QKL+ +
Sbjct: 2240 AEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
Query: 2300 SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASA 2349
+ GTLK A + V++ + + K + + C Q KD++ L S
Sbjct: 2300 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQ 2359
Query: 2350 KQEMECC---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDW 2403
+ + LNS+ + S E + T ++ +A S + TQ S E LE+ +
Sbjct: 2360 QSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHF 2418
Query: 2404 EINKDSAVEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ----- 2454
+ E + + + A+ES T D E K+++LQN LD++ +
Sbjct: 2419 SESMQEFQEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAV 2473
Query: 2455 LEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKN 2514
+E + LY L + I Q + E L Q L + L + +
Sbjct: 2474 TQEGQTLYAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQ 2530
Query: 2515 KESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSL 2574
+ + +E + + L K+ + + + K++ F+ + ++SL
Sbjct: 2531 HRKLNLWIHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESL 2581
Query: 2575 GNLKIKWENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLM 2632
L + + LS H + +L QL + + + ++K V E L
Sbjct: 2582 DKLSQRGQLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALE 2637
Query: 2633 NKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKR 2692
+Q S+ + +Q RL E G++ + + ++KG+ E+++
Sbjct: 2638 EALQ----SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNM 2690
Query: 2693 IWGEKE---KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGE 2749
G+ E + + ++G ++ Q ETL+ +WA +
Sbjct: 2691 AIGKGEQALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSS 2728
Query: 2750 LNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDL 2804
++ L + ++SQ + + R+ +E E V K+ P E L
Sbjct: 2729 VHAQSTL--ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL 2779
Query: 2805 NNTLEDLRNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRV 2861
+ L+ + ++ + + + +S++L K E+ S F + +L Q ++ + + +
Sbjct: 2780 LDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKE 2837
Query: 2862 ETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKN 2919
+ E +K H + L+A + + S L +++ + + ++ +++ + +
Sbjct: 2838 KMRKVEEIVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDS 2896
Query: 2920 LKIRTNRIQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEV 2973
+I +R+ R +++ EV+ C H + AL+ + DS+ + + L V
Sbjct: 2897 REIGASRLSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV 2955
Query: 2974 NKGVKEE------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQ 3019
++ E + L+ L + L +L+ K + I W Q LD
Sbjct: 2956 SQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDA 3015
Query: 3020 LQTQVFEKEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAP 3073
LQ + + ++L+ ++ +L F + GK L+ + + LQ K + +
Sbjct: 3016 LQ-KAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQ 3074
Query: 3074 DSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKL 3133
R +++ +I AKC +I + ++E T K +E L N + +
Sbjct: 3075 RFRKAFRDFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNM 3130
Query: 3134 YKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDN 3191
++ L KE K Q K+ + S L Q L NL+I+ +++ + +
Sbjct: 3131 MLSKGELLSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVS 3188
Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
E Q+ W ++ EK E+S+ D+ K RE + LQ L
Sbjct: 3189 AEPIQD--W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI-------- 3230
Query: 3252 NDAYE-NLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI 3310
YE L R KE + E + ++ + +L S +
Sbjct: 3231 -HCYEPQLNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLAL 3271
Query: 3311 QDLT-EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRK 3366
+LT EK+ L +V++++ K + T+A L++Y C+
Sbjct: 3272 SNLTKEKVS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPT 3317
Query: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
++ + + +L L EAL ++Q K + +I T+ E +
Sbjct: 3318 SDKSVLDS------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV-------- 3354
Query: 3427 LRLRCTENDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
L+ T +GI + + + ++ + W SLL A + E +W + + + + +
Sbjct: 3355 --LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWM 3412
Query: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
D+++ L E + + +EL D G K +LL +L ++ + E
Sbjct: 3413 DSMEANLNE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVK 3459
Query: 3546 GAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTS 3605
GA T +T ++ LQ +Q+ +Q +E + +++++ L +Q+ +
Sbjct: 3460 GAGMTE---HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA 3510
Query: 3606 FQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
F+ Q+ EK +Q+ L+ + T ++ E L++ +E ++ + + ++ +
Sbjct: 3511 FEVWLGQEQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIP 3568
Query: 3666 KALEDIDEKISNEVLKSSPSY-----AMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
+ +++ + + +Y R + + N L +E+ QQ + ++ A+E
Sbjct: 3569 SGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-- 3626
Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
KK +E+ + ++ E+ + Q+I+++ ++ + +YQ + + + L
Sbjct: 3627 KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQALLLQVLEQIKFL 3685
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHASTVQMALEDSEQK 3837
+ +EE L S W +T N A D + T + T+++ L+D E+
Sbjct: 3686 EEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKG 3745
Query: 3838 HNLLHS----------IFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQR 3887
H+LL S + E + E + + ++EL++ V + + L +
Sbjct: 3746 HSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKE 3805
Query: 3888 MADDVVAI---------------ESEVKSMEKRVSKIKTILLSKEIFDFSP--EEHLKHG 3930
+D A+ E +++ EK+ K L + + P + + G
Sbjct: 3806 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3865
Query: 3931 EVILENIR--PMKKTIAEIVS-YQVELRLPQTGMKPLPVFQ-RTNQLLQ----------- 3975
E +LE ++ +K I ++ S YQ + + M+ + F+ R N L
Sbjct: 3866 EALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCAD 3925
Query: 3976 --DIKLLENV---TQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEH----MSP 4026
KL +NV Q + + + +E+ ++ + S Q +L+ +S
Sbjct: 3926 HLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH--ELQKHVSRQDTLQQCQAWLSA 3983
Query: 4027 DQADKLPQLQGEIERME--KQILSLNQRKE------DLLVDL----KATVLNLHQHLKQE 4074
Q D P Q + R E KQ+ +E DLL + A+V + ++Q
Sbjct: 3984 VQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQT 4043
Query: 4075 QEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
++ +E+ + A +G E K + YL +++++ ++K + + +
Sbjct: 4044 EQTIEQKLVQAQNLTQGW------EEIKHLKSELWIYLQDADQQLQ--NMKRRHSELELN 4095
Query: 4135 PSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC 4194
+ S + K ++ +AS ++ + E K++ + S + + LN + C
Sbjct: 4096 IAQNMVSQVKDFVKKLQSKQASVNT---IIEKVNKLTKKEES-PEHKEINHLNDQWLDLC 4151
Query: 4195 SLRPN---QTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA----- 4246
N Q EE T D D +E +EK E + + A
Sbjct: 4152 RQSNNLCLQREEDL-----QRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEA 4206
Query: 4247 --ELELWLQQANVAVEP---------ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLE 4295
+L L LQ+ A+E E LN D ++++++Q + ++E
Sbjct: 4207 LKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE-------- 4258
Query: 4296 TCKDQGLGDNGATQHEAEALSLKLKTVKCNLEK---VQMMLQE--KHSEDQHPTI---LK 4347
+ + K++ NLE+ VQ QE + +E+Q P I LK
Sbjct: 4259 -----------------DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4301
Query: 4348 KSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAK 4407
+S P+ + L L + +I +E LE K M K IK +A
Sbjct: 4302 QSPPPDMAQNL----LMDHLAICSE---------------LEAKQMLLKSLIK----DAD 4338
Query: 4408 KMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPL 4467
++ ++ Q+ A + A S N + D + G + +YL+ LS K + +
Sbjct: 4339 RVMADLGLNERQVIQK--ALSDAQSHVNCLSDLV-------GQRRKYLNKALSEKTQFLM 4389
Query: 4468 P--------QLVEPQV--STNMGILPSVTMYNFRYPTTEE--LKTYTTQLEDLRQEASNL 4515
Q E ++ ++ +LP + + + LKTY ++ L + L
Sbjct: 4390 AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGREL 4449
Query: 4516 QTQENMTEEAYINLDKKLFEL----FLTLSQC---LSSVEEMLEMPRLYREDGSGQQVHY 4568
+ +TE+ + KL EL L +C L +E+ L + ++ED + H+
Sbjct: 4450 --MKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKED-FDKACHW 4506
Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLEC--FDNLQVCLEHTQAAAVCRSK 4626
A + + L ++ +L T + N+L + ++NL + L+ T +
Sbjct: 4507 LKQADIVTFPEINLMNESSEL---HTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563
Query: 4627 SLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNE--ISGQSVAEQLQKADAYTVELEN 4684
+ Y N + R ++ ++ + E ++ + A ++ ELE
Sbjct: 4564 EVDH--SYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621
Query: 4685 AESRVAKLRDE---GERLHLP---YALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTES 4738
R++K+ + E L L A+L EV L + +D + + + P+ +
Sbjct: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL-NQKKEGFRSTGQPWQPDK 4680
Query: 4739 QQDALLQGMVELVKIGKEKLAHGHLKQTKSKVAL----QAQIENHKVFFQKLVADMLLIQ 4794
M+ LV L H +QT+ +V+L + + H+ Q+L + ++
Sbjct: 4681 --------MLHLV-----TLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4727
Query: 4795 AYSAKILPSLLQNRETFWAEQVTEV-KILEEKSRQCGMKLQSLL------------QKWE 4841
+K+ N ET AE+ ++ L + G+ L+ + +E
Sbjct: 4728 EEQSKV------NEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4781
Query: 4842 EFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNE 4901
+ S + +L++L S + V E E R+V+ I F ++ R++ R+ L+
Sbjct: 4782 KARHQIQSWQGELKLLTSAIGET--VTECESRMVQSIDFQTEMSRSLDWLR-RVKAELSG 4838
Query: 4902 GKQLVASVSCPELEGQIAKL----EEQWLSL----------NKKIDHELHRLQALLKHLL 4947
L ++ +++ +I K+ EE SL +K + A L+H L
Sbjct: 4839 PVYL--DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSL 4896
Query: 4948 SYNRDSD-QLTKWLESSQHTL-----------------NYWKEQSLNVSQ------DLDT 4983
+ + D + + L + Q TL N W E + + Q D+++
Sbjct: 4897 AELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVES 4956
Query: 4984 IRSNINNFFEFSKEVDE-KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLIT 5042
N+ + EF D+ S+L+ + +K T L +A E + +
Sbjct: 4957 AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSR 5016
Query: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
+ L + + +KA E+I MN+ E + S E S+ SS+ + + L +HK
Sbjct: 5017 DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS-EFSLLKTSSSHEAEEKLSEHK 5075
Query: 5103 EFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT-------EFAEHLGEMNRQWHRVH 5155
+V VN ++ + ++ + E+T + + + ++W R+
Sbjct: 5076 A----------LVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLR 5125
Query: 5156 GMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQD- 5214
+ + + LE ++ T NK++ ++ +++L ++ + LL+ D
Sbjct: 5126 AVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDT 5185
Query: 5215 IENQLAIKSKALDELKQSYLT-LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQ 5273
+L + AL L+Q L+ L+ GA P + + E+ + L ++KT+ +
Sbjct: 5186 FVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245
Query: 5274 SVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGS 5333
V QE K + + ++N +++ W E + + + Q+E LQ L EA + +
Sbjct: 5246 LVKQELKDREMVETQIN--SVKCW-VQETKEYLGNPTIEIDAQLEELQILLTEATNHRQN 5302
Query: 5334 WEKL-QEVIGKLKGL---CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389
EK+ +E K GL PS + + K Q+ I + Q + +L +
Sbjct: 5303 IEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQ 5362
Query: 5390 YSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKE 5444
+ L + +AK + L E L + EL VQK E
Sbjct: 5363 IQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLE 5417
Score = 117 bits (292), Expect = 5e-25
Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)
Query: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
Y+ +K +LI +Q+ +I + Q + QK + + + + ++
Sbjct: 1244 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1303
Query: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
A+ + +GE LP +E+ KLE LD G+ R+R + VT + +
Sbjct: 1304 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1358
Query: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
+V+ + + +H S +L +++E K F ++ + + +QA + A +P
Sbjct: 1359 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1416
Query: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
QN++ + + +VK LE+ + ++ + KW+ F N+ +L EK+L
Sbjct: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
Query: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
L ++ ++ + ++E E +L E SF Q + + A+L Q
Sbjct: 1477 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1536
Query: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
G++L C LEG I LS +K + L ++Q S + D+L
Sbjct: 1537 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1584
Query: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
++ +K ++ +++ Q L+++ S I F +++V + S ++ Q
Sbjct: 1585 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1644
Query: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
L KE TA L A + E++ + +T L + K +M+ R + +
Sbjct: 1645 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1704
Query: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
+ ++++ + S +S LLQ + +SL +++ D
Sbjct: 1705 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1737
Query: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
+ HL +++ +W + ++N++I L+ ++ + + + + W++
Sbjct: 1738 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
Query: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
L+T + S++ Q L +D ++ K L L+ L S + LL+
Sbjct: 1793 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1851
Query: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
A +LF++ S V+ + + + LQ + ++ T+ M ++
Sbjct: 1852 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1910
Query: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
++ + L ++N ++L+ A S +G K Q + I Q T R
Sbjct: 1911 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1957
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
T + ++++ Q+LL KQ EA LA + + + E L
Sbjct: 1958 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1998
Query: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
+++DI+E + + T++A Q V ++L S H L +A + +
Sbjct: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2054
Query: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
+ A E + +++ + V + K LI HE + +L R +Q K L
Sbjct: 2055 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2110
Query: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
+ ++ I+ ++ + A + + T+ SEL+ I ++
Sbjct: 2111 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2170
Query: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
L +KW+ + EK+EE L+V ++ N +P++ E
Sbjct: 2171 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2230
Query: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
++ K E+EV + ++ L + T+ +E P+ + L
Sbjct: 2231 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2290
Query: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
+ ++A + KG + +DFT + +F+ D + L++ + +
Sbjct: 2291 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2343
Query: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
+L + + + EL++++ + + + C A + L +T +K E+V +
Sbjct: 2344 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2403
Query: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
S+ Q S ++ +E +E +++FQ K+ + +VL+A+ LH D
Sbjct: 2404 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2455
Query: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
L N + + + + L + TQ E QT+ A L++ + V ++EQI + +++
Sbjct: 2456 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2508
Query: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
+ KQ ++D + F +++++L W+ +ME + T ++ + +K+ + ++
Sbjct: 2509 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2567
Query: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
+F L ++ D+L + S + A + +L +++ Q+L + +++ +
Sbjct: 2568 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2627
Query: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
+ L++ + ++ W+ I+ L+ + ++KRL++ QD+ +
Sbjct: 2628 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2686
Query: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
+ + L S N+ IQ +L W +I + S+ + +E W
Sbjct: 2687 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
Query: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
+++ ++ E W++S ++ P + VL + L E R +H +
Sbjct: 2743 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
Query: 6192 QLELINKQYRRLARENRTDTA 6212
+ + Y + E+ DTA
Sbjct: 2803 K---SRELYEKTEDESFKDTA 2820
Score = 105 bits (262), Expect = 2e-21
Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)
Query: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
+ K T L ++ + SN E +L+ EL + E++L+
Sbjct: 1218 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1273
Query: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
L+ + +H++ + K++ D + + +A G + E L+ L
Sbjct: 1274 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1328
Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
+ + + + + ++ L ++ + + L ++ +S ++ L+ S +S++ +L++
Sbjct: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1388
Query: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
++ E+ + L E + L ++ ++V KLED L+
Sbjct: 1389 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1448
Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
M++ ++ S F T S V I +++ L+ + S A+ QI K
Sbjct: 1449 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1494
Query: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
V Q++ ++ ++ ++ + + ++T+++ E+ R+ L+
Sbjct: 1495 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1554
Query: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
L + ++F+EN +++ + + L + S ET + L E + Q ++
Sbjct: 1555 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1610
Query: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
+ + +++V SC + + A L++Q+ + ++ L+ LL H
Sbjct: 1611 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1667
Query: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
++ WLE + + +++S D + + EV ++S + ++
Sbjct: 1668 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1724
Query: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
+ L + + D ++ L Q +++W LP I K + + E+
Sbjct: 1725 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1780
Query: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
+ W+ E QT+ E S+ A L +HK+ E++ K+ + + L
Sbjct: 1781 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1834
Query: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
+L + + S+ ER + A HL E + + G+L +
Sbjct: 1835 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1894
Query: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
Q +E L++ E+ L+ L + LK + Q+
Sbjct: 1895 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1954
Query: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
+ +L + + I+N L K AL LK+++ + + +ED R D+ K
Sbjct: 1955 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2014
Query: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
+ + Q++ Q ++++QL DE+N + + +K + +V
Sbjct: 2015 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2063
Query: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
+ E E +W+ + +I + +G C + +++ E + + A++ L
Sbjct: 2064 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2109
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
+ A S++ + A K + AK + L N + G +L +E+
Sbjct: 2110 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2169
Query: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
D ++ D++ T + +L S L DRL E ++ +P
Sbjct: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2229
Query: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
++ +L L+K EFE S+ K+ +RLE L + +L L + + PD
Sbjct: 2230 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2280
Query: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
L + A Q +EH E++ K L D ++ Q N W +L
Sbjct: 2281 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2336
Query: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
C++ NE CE K ++ ++K ++ + +++++ L + Y E E S+
Sbjct: 2337 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2385
Query: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
+ + QL T+ + FS+ +Q G + R GD
Sbjct: 2386 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
Query: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
L + D ++N+ ++D L AV QE +LY H K Q +
Sbjct: 2446 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2495
Query: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
T +A K L D + + + +D + + + EM ++F + E +
Sbjct: 2496 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2552
Query: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
++ I E K+ + ++ + L E + L +L+ E + +L T
Sbjct: 2553 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2612
Query: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
+L R + KE++ +VA+++ E E + + W
Sbjct: 2613 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2646
Query: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
+ +++++ + + ++ +EK + + + E +++L G+Q +++SNK
Sbjct: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2706
Query: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
I +L + + W D++ S V + I Q + + + L W+ ++ ++
Sbjct: 2707 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2763
Query: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
P+ + Q L E+ L ++ + E L+ S +TE +S
Sbjct: 2764 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2815
Query: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
+ T + L ++ +I ++ E+ K+EE + +LD F DWL SA+ +
Sbjct: 2816 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2875
Query: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
++ +++L + + R+I RL+++E + + ++ + + Q +
Sbjct: 2876 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2935
Query: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
++W++ L+ V+ + + F+ Q + E E L QLT +E
Sbjct: 2936 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2994
Query: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
+ D+++ + QEI +QK+EP L + +L EL R+
Sbjct: 2995 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3037
Query: 6334 QEV 6336
+++
Sbjct: 3038 RDL 3040
Score = 98.6 bits (244), Expect = 2e-19
Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)
Query: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
+L D ER H + + + K+E L +Y LS + ES+ + +
Sbjct: 488 QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 534
Query: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807
+K G+ + L+ S + E ++V +Q K A+M + S + ++++
Sbjct: 535 -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 592
Query: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867
F E + + L + R L+ ++ W+ + ASL+ + +
Sbjct: 593 ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 636
Query: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927
E+ E+ L + + + RN+ + + +N+ + +C E+ + L++Q L
Sbjct: 637 EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 692
Query: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984
LN R + L + Y + + D++ K TL+ + E +S+ L+
Sbjct: 693 LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 745
Query: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042
N+ + ++++++ + A I + HL KE+ + A + L
Sbjct: 746 FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 805
Query: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
L++ Q +P + +M S+ +++ + + +S + QKH+
Sbjct: 806 VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 863
Query: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159
E + +++ +QS+ + T K +++T + +++ + +
Sbjct: 864 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 923
Query: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219
+H+E + + E L L +E L+ PE ++ D + L
Sbjct: 924 DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 982
Query: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277
KA DEL + +L + Q L+ +++ + +
Sbjct: 983 NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1013
Query: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337
+WK L E + +E ++ + S+E R +++ L + EGS + +
Sbjct: 1014 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1065
Query: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379
+E V KG LC ++IEE C H ++ AI +K
Sbjct: 1066 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1125
Query: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439
WK Y++ E ++ + E + + + ++ N E+ + ++E+++ V
Sbjct: 1126 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1181
Query: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
K E S + RL E S+ L + + K L+ +E E +LS F
Sbjct: 1182 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1238
Query: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558
D K ++ + E L ++ +E + L+ AQ + H + +
Sbjct: 1239 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1294
Query: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605
DV + Q + + +T LER E Q + KW
Sbjct: 1295 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1350
Query: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646
Q E L SL LEQ K + ++AE + +
Sbjct: 1351 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1410
Query: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706
Q+ QLL + + KL D + ++ + K +W F
Sbjct: 1411 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1459
Query: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760
++ E L ++T+ L+A++ + Q + I E+++K + + + A
Sbjct: 1460 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1519
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
+ GE + L + R +L++ + +E + + Q Q E + ++ +
Sbjct: 1520 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1576
Query: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879
E + +L V +K S E ++ L +L + LE +L T + R V
Sbjct: 1577 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1626
Query: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939
+ D V ++ L +Q+ED+ R R+ +E+ L W ++ WL + E K
Sbjct: 1627 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1684
Query: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990
DIS + ++I+ LQ + + + + +S +L Q+ + L ++K
Sbjct: 1685 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1740
Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
+ L ++++RW+ L +I R+ L+ A QQ D+ + + W+ SEL
Sbjct: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800
Query: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099
+ D Q E++ + E Q LQ H A + S+ D+ L A
Sbjct: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1853
Query: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159
E ++ ++ ++RR + ++ +FL ++ L+ +T
Sbjct: 1854 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1898
Query: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
NS S+++ + L+ +A + L + + E RT +
Sbjct: 1899 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1958
Query: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270
Q+ E +R NL Q A+ + F +Q+EE + E I E
Sbjct: 1959 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2012
Query: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
++ + ++R N + E+ + +++ L +Q+ QK
Sbjct: 2013 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
Score = 91.3 bits (225), Expect = 3e-17
Identities = 427/2312 (18%), Positives = 886/2312 (38%), Gaps = 391/2312 (16%)
Query: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 6511 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6566
Query: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 6567 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6623
Query: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 6624 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6683
Query: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 6684 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6738
Query: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 6739 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6798
Query: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 6799 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6858
Query: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
QK E +K + IH LQ G N +T + +S
Sbjct: 6859 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6918
Query: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 6919 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 6964
Query: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 6965 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7024
Query: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 7025 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7083
Query: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 7084 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7143
Query: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 7144 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7203
Query: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 7204 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7260
Query: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 7261 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7313
Query: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 7314 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7373
Query: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 7374 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7430
Query: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 7431 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7487
Query: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 7488 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7547
Query: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
+ + + L S LQ + I K + L + A L
Sbjct: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7601
Query: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 7602 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7657
Query: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
Query: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 7718 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7772
Query: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 7773 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7829
Query: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
L + E +E + I+ +C
Sbjct: 7830 LAHIE------------------------------------------SELAKPIVYDSCN 7847
Query: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7907
Query: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
R + I + E +IE + L QK L D S W + + + S
Sbjct: 7908 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 7956
Query: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 7957 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 7999
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 8000 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
Query: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 8047 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8097
Query: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
+ + + + + II++++ L+ C + +R +K
Sbjct: 8098 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8140
Query: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 8141 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
Query: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
R + + PLE D L LE+ + P E E + +
Sbjct: 8198 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8246
Query: 2490 VLHNIGYSAQHLDNLLQALITLK----KNKESQYCVLRDFQEYLAAVESSMKALLTDKES 2545
+ +G S + +A + L KN + L L + + E+
Sbjct: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 8306
Query: 2546 L-----KVGP-LDS--VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLE 2597
+ GP LD+ Y+ + + +SI+ K LK + E+L V + E
Sbjct: 8307 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV---NLHSTE 8363
Query: 2598 SQIKQLEHGWEQVEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ--- 2647
+Q + WE ++ Q K Q + ++ +F + +N + DTE L+Q Q+
Sbjct: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8423
Query: 2648 -------HLQL-RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
LQ+ +LK ++ ++ I L+ +L + + QA+ KE
Sbjct: 8424 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKES 8469
Query: 2700 KNLEDGINNLKKQWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSI 2754
++L+D ++ + +W+ LE ++ + +C ++M +L +N+ N +
Sbjct: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
Query: 2755 PL---LPDDILSQIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLE 2809
P+ L +IL K ++ H+ +L Q V SL + L EG+D E
Sbjct: 8530 PIDSNLDAEILQDHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKE 8585
Query: 2810 DLR---NQYQMLVLKSTQRSQQLEFKLEERSN 2838
+ N+ ++L+ + ++ ++LE L+ S+
Sbjct: 8586 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS 8617
Score = 66.2 bits (160), Expect = 1e-09
Identities = 672/3633 (18%), Positives = 1382/3633 (38%), Gaps = 481/3633 (13%)
Query: 706 VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
V L E +Q K G K + +T VA+D EK++ V+ W
Sbjct: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
Query: 756 VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
V ++ +++ L A+ + EL+ E D ++++ Q+S +L
Sbjct: 5149 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5205
Query: 814 AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
+ +Q+ L+ + + D L+++ K++ + K ++ + + + Q S
Sbjct: 5206 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5263
Query: 874 PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
+ + KE L + T + L+ ++ L T ++I+ EE+ + L
Sbjct: 5264 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5322
Query: 931 HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
ELSL + ++ +D++ + ++ D I ++E+ ++L R+ + K L ++
Sbjct: 5323 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5382
Query: 988 CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
+ Q +VL EEL S+ L + + +++ L+ ++ L G
Sbjct: 5383 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5433
Query: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
T ++ TI +ENR + A + N+ EKA T+ ++ AS LR
Sbjct: 5434 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5493
Query: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
+ ++++E K+ + + ++ E+ + + + ++ E + ++
Sbjct: 5494 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5550
Query: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
+L +LQ + E + + LE + P V R +LKE+ Q L +
Sbjct: 5551 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5607
Query: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
MESL+ ++ V LC S L + + + L A R+ + +Q + +Q
Sbjct: 5608 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5658
Query: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
CN MQ +++Y+ + M H Q E + +ED
Sbjct: 5659 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5692
Query: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
++ + +L A ++ +E +K + +I + K K L K M E
Sbjct: 5693 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749
Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
LD + H V + LL ++ E + S+IS
Sbjct: 5750 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5804
Query: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
+ P T +V L + + K H A S ++ G E +
Sbjct: 5805 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5863
Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
+ + WE K +++E LE ++YQ+ ++T ++ E + L S
Sbjct: 5864 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5921
Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA-----N 1621
+ + ++AE + + +E L + D+IN++ +L L ++ E P E+ A
Sbjct: 5922 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQLALQSTLT 5977
Query: 1622 IIVDRWLDI-----------NEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKME 1670
++ +R I EK D E + AL + + +D W ++
Sbjct: 5978 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL-QRYRCEADELDSWLLSTKATLD 6036
Query: 1671 LHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHV 1730
++ ++ +L + E ++V + L + E ++E K E
Sbjct: 6037 TALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL----SVHNENLLLEGKAHTKDEAE 6092
Query: 1731 QKCLTGESNCHALSGSTAELREDLDQAKTQIGMT----ESLLKALSPSDSLEIFTKLEEI 1786
Q L G+ L GS EL+ L + + T E L+ + S + L +
Sbjct: 6093 Q--LAGK--LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQA 6148
Query: 1787 QQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLND---- 1842
+ QQ+ S + + + L EL+E K SV+ ++ ++Q ++ D
Sbjct: 6149 RTTWTQQRQSSLQQQKE---LEQELAEQKSLLRSVAS--RGEEILIQHSAAETSGDAGEK 6203
Query: 1843 -----QCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
Q S+ + ++ +ES + S +QKL L + L E + + +
Sbjct: 6204 PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL--LQNVLEQEQEQVLYSRPNRL 6261
Query: 1898 LKHV---KKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRN 1954
L V K +P + S L G E++ S AK L+Q +L D
Sbjct: 6262 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSS-QSGGAKRQSIHLEQ--KLYDGVSA 6318
Query: 1955 LRKWLTNQEEK-WKGMEEPGEKTE--LFCQ-ALARKREQFESVAQLNNSLKEYGFTE--E 2008
WL + EE+ + E+TE LF Q LA+ ++ N +L F E +
Sbjct: 6319 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 6378
Query: 2009 EEIIMEAT--CLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
++E T CL+ R L +++ + K + +F + + + + K ++
Sbjct: 6379 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQ 6438
Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE--SSEAPLVQKTLTDISNQWD 2124
++ + P+ E+I+ I++ E DA I + ++ + E P +Q+ L+ + + +D
Sbjct: 6439 KLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE-LSKLQDMYD 6497
Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG-----FALQHGLQEKK 2179
+ + + S + L +Y ++ +DL L+E +++ AG + + +Q+
Sbjct: 6498 ELMMIIGSRRSGLNQNLTLKSQYERALQDL-ADLLETGQEKMAGDQKIIVSSKEEIQQLL 6556
Query: 2180 AQLKIYKKFLKKAQDLTSLL----------KELKSQGNYLLECTKNPSFSEEPWLEIKHL 2229
+ K Y + L+ LT L KE + + + + + + +E++++
Sbjct: 6557 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6616
Query: 2230 HESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKL 2289
E+ L + Q L R+ + + + + +N D+ +D+I + + L
Sbjct: 6617 LET-WSHLDEDQQELS---RQLEVVESSIPSVGLVEEN--------EDRLIDRITLYQHL 6664
Query: 2290 Q-KLQELENRL--SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRL 2346
+ L E + +L L DG I ++ + +G+ + + K K+L
Sbjct: 6665 KSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK----MSKELHR-- 6718
Query: 2347 ASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEIN 2406
L +ILK + + + + A ++ TQ+S V ++ E+
Sbjct: 6719 ----------LETILKHWTRYQSESADLIHWLQ-SAKDRLEFWTQQSVTV---PQELEMV 6764
Query: 2407 KDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLEL---DTMLRNEQLEEIEKLYT 2463
+D + + ++AQ S+K++ V NQ L L DT +L I+ +T
Sbjct: 6765 RDH-LNAFLEFSKEVDAQSSLKSS-----VLSTGNQLLRLKKVDTATLRSELSRIDSQWT 6818
Query: 2464 QLEAKKAAIK---------PLEQTECLNKTETGALVLHN------------IGYSAQH-- 2500
L A++ L +++ + ++ N IGY A H
Sbjct: 6819 DLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEY 6878
Query: 2501 -----------------LDNLLQALITL-KKNKESQYCVLRDFQEYLAAVESS---MKAL 2539
+D + Q+++ + ++ ES+ DF E L A+ S ++ L
Sbjct: 6879 LQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 6938
Query: 2540 LTDKESLKVGPLDSVT-YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES 2598
+T+K L G L+S + Y + ++ E ++ L + S D + LE
Sbjct: 6939 VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLED 6998
Query: 2599 QIKQLEHGWEQVEQQ----IQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLK 2654
IK E E++EQ IQ K ++ V +TL ++ T +L L++ LK
Sbjct: 6999 LIKAKEKEVEKIEQNGLALIQNK--KEDVSSIVMSTL-RELGQTWANLDHMVGQLKILLK 7055
Query: 2655 SPEERAGNQSMI--ALTTDLQATKHG---FSVLKGQAELQMKRIWGEKEKKNLEDGINNL 2709
S ++ + + + + L ++ F +L G E ++ NL++ ++L
Sbjct: 7056 SVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV------DNLQNLQDDL 7109
Query: 2710 KKQWETLEPLHLEAENQIKKC------DIRNKMKETILWAKNLLGE----LNPSIPLL-- 2757
+KQ +L+ +K+C + N +KE + NLL E L S LL
Sbjct: 7110 EKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL 7169
Query: 2758 -----------------PDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYE 2800
+D +++ K D V + ++ D + L T +
Sbjct: 7170 WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVK 7226
Query: 2801 GS--DLNNTLEDLRNQYQMLVLKSTQRSQ--------QLEFKL-EERSNFFAIIRKFQLM 2849
S L+ E L+ Q + Q Q LE L +++++ A + ++
Sbjct: 7227 DSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETF 7286
Query: 2850 VQESETLIIPRVET-AATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELN-V 2907
+ E L VE + + H L Q+ ++E+ G + + LN +
Sbjct: 7287 AKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL-KGQMLKFSSMAPDLDRLNEL 7345
Query: 2908 FERLFLED----QLKNLK-----IRTNRIQRFIQNTCNEVEHK--IKFCRQFHE-KTSAL 2955
RL L D +++NL I + +RF + ++H+ ++ C + E
Sbjct: 7346 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTE 7405
Query: 2956 QEEADSIQRN--ELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWD 3013
Q+ A I N LL Q ++ + E+++ + L +I ++L+ +V D N
Sbjct: 7406 QKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7465
Query: 3014 FSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVV 3069
+ L V + ++ ++ +I+Q + E K + L ++ + + +
Sbjct: 7466 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP 7525
Query: 3070 LKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEE 3129
L+ + + + ++ R + + L E K+L + DS E LQ +L AE
Sbjct: 7526 LQQARTLFDEVQFKEKVF-LRQQGSYILTVEAGKQLLLSA---DSGAE-AALQAEL-AEI 7579
Query: 3130 NDKLYKVLQNMVLELSPKEL-----DEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKH 3184
+K +M LE K+L D + C+ + SL L K +L Q L + E H
Sbjct: 7580 QEKWKSA--SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELH 7637
Query: 3185 IQNEKDNCEAFQEQV--W----AEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQM 3238
E+ C+ + V W ++ +K + ++ S VE R++E+L
Sbjct: 7638 A--EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7695
Query: 3239 QLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEA-------IIIPYRVDVGNPEE 3291
QL+ LR + + + E E +T +E+ I+I ++ +
Sbjct: 7696 QLS----LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDY 7751
Query: 3292 SLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE 3351
E+ + ++ +++ +Q + E+L S +++Y L ++ + + + A+
Sbjct: 7752 QEEIAIAQENKIQ-----LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 7806
Query: 3352 TEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLI 3411
+ + L + K + T L+ +E+ L + + + E +L + + L ++
Sbjct: 7807 KKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 7866
Query: 3412 STKEELMKLRQILRLLRLRC----TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEEL 3467
+ + + +L C T+ + + + L +W ++ + E + EE
Sbjct: 7867 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 7926
Query: 3468 KQEWKFVSEEIEREAIILDNLQE--ELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ 3525
+ W+ ++ R L + + P S EEL + + V +
Sbjct: 7927 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE----AFQRQVHECL 7982
Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
L L+ ++ R + + A E + K + + + + + +E
Sbjct: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
+ I+ T+ ++ + D K +Q + Q + E I+ +
Sbjct: 8043 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8102
Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
+ + A IE +++E R+ +++ ++ R + I L + E
Sbjct: 8103 IEKSEPLDAAIIEEELDELRRYCQEVFGRVE------------RYHKKLIRLPLPDDEHD 8150
Query: 3706 LQQKSKNIEKAQEIQKKMW-----DELDLWHSKLNELDSEVQDIVEQDPGQ-AQEWMDNL 3759
L + +E + + W D L N S Q + + G+ +D++
Sbjct: 8151 LSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI 8210
Query: 3760 MIPFQQYQQVSQRAECRTSQLNKATVKMEE---------------YSDLL--KSTEAWIE 3802
+ + +S+ E S +++A +E SD++ +S EA+++
Sbjct: 8211 PLEWDHDYDLSRDLE---SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVK 8267
Query: 3803 NTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQ 3862
T + + N + S L + AL+DS + I +T+ + +
Sbjct: 8268 LTENAIKNTSGDHS--ALESQIRQLGKALDDSRFQ----------------IQQTENIIR 8309
Query: 3863 SIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSK-EIFDF 3921
S ++ + M+ L + D V +E ++K E+ + + ++ +
Sbjct: 8310 SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8369
Query: 3922 SPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLE 3981
L + + + +R MK+ + + + +L + T + L+ ++ LE
Sbjct: 8370 IDRWELLQAQALSKELR-MKQNLQKWQQFNSDLNSIWAWLGD------TEEELEQLQRLE 8422
Query: 3982 NVTQEQNELLKVVIKQTNEWDEEIENLKQI---LNNYSAQFSL--EHMSPDQADKLPQLQ 4036
T Q +++ IK+ E + +++ K I +N S +F+ S D D+L Q+
Sbjct: 8423 LSTDIQT--IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMN 8480
Query: 4037 GEIERMEKQILSLNQRKEDLLVDLKATVLNLHQ 4069
G +R + SL + LL D H+
Sbjct: 8481 GRWDR----VCSLLEEWRGLLQDALMQCQGFHE 8509
Score = 65.1 bits (157), Expect = 2e-09
Identities = 325/1714 (18%), Positives = 644/1714 (37%), Gaps = 315/1714 (18%)
Query: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 6994 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7040
Query: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 7041 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7100
Query: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 7101 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7156
Query: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 7157 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7212
Query: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Q C ++ K L A I + + +C + +
Sbjct: 7213 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7272
Query: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 7273 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7332
Query: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 7333 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7386
Query: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 7387 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7442
Query: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 7443 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7502
Query: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 7503 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7562
Query: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 7563 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7622
Query: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 7623 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7682
Query: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 7683 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7742
Query: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 7743 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7801
Query: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 7802 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7861
Query: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 7862 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7919
Query: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 7920 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 7979
Query: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 7980 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8039
Query: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 8040 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8099
Query: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
++++ P D ++ + + + + + RV+R L
Sbjct: 8100 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8159
Query: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQ------VAQENTLTVKN----KEGEIH 1368
AL D R+A LS +P ++LS S Q ++ +V + + +
Sbjct: 8160 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 8219
Query: 1369 LMKDKAKHLDKCLKMLDMSFKDAE----RG----DDTSCENLLDAFSIKLSETHGYGVQE 1420
L +D + + L D +D + RG D +A+ +KL+E +
Sbjct: 8220 LSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAY-VKLTE----NAIK 8274
Query: 1421 EFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKKSLIRL--- 1473
+ ++ LE+ I +L K + D + QI + I K PT P + K ++L
Sbjct: 8275 NTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8331
Query: 1474 -DKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGR 1532
+D + + L+E SLP F + + Q + WE L + L + R
Sbjct: 8332 CSSSIDSVKRLEHKLKEEEESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELR 8386
Query: 1533 VLELLKQYQNFKSILTT----LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHL 1588
+ + L+++Q F S L + L EE + LQ + L I IE+ ++ E
Sbjct: 8387 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQ 8441
Query: 1589 EVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW 1648
+ VD + ++ P F + ++++ D + L + W
Sbjct: 8442 KAVDHRKAIILSINLC--------SPEFTQAD----------SKESRDLQDRLSQMNGRW 8483
Query: 1649 DKLFNLKNVIDEW----TEKALQKMELHQLTE------EDRERLKEEL-----QVHEQKT 1693
D++ +L ++EW + +Q H+++ E+ +R K E+ + +
Sbjct: 8484 DRVCSL---LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 8540
Query: 1694 SEFSRRVAEIQFLLQSSEIPL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELRE 1752
+ +++ +I+ L S++ + LQ M +L E CL + H + L+
Sbjct: 8541 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKL 8596
Query: 1753 DLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEI 1786
L + I E LL S L ++ +E+
Sbjct: 8597 LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 8630
Score = 41.2 bits (95), Expect = 0.036
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
Query: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 8433 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8488
Query: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
L++E L + + + E +LL EN D +VP
Sbjct: 8489 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
Query: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8596
Query: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
LL++ + I+E E L + +S Q
Sbjct: 8597 LLKEVSRHIKELEKLLDVSSSQQ 8619
Score = 39.3 bits (90), Expect = 0.14
Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)
Query: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
++ + KE++ + + ++L Q ++++L +H V+ M K QIEHL HR
Sbjct: 323 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 381
Query: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
+ L L A+ KQ + RL W + +K+ + AWL + E V +I++
Sbjct: 382 DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 438
Query: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
+++ E+ ++ + N K+ ++ + + + D+L + +R+
Sbjct: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 498
Query: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
+ + K L+ + + L S L++W+ + S +++ +
Sbjct: 499 VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 549
Query: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
+ + EQ+ + + ++ + A + E +++ + +WRN+
Sbjct: 550 YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 606
Query: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
R +EE W ++ + + + WL+ AE+ N SE +AK++ F
Sbjct: 607 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 653
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
R + + Q +N L + LKQ + N RW L V +
Sbjct: 654 FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 712
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
++E+ ++ + TE +L+ S + ++ L +Q + + + +
Sbjct: 713 MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 771
Query: 6303 LIVFGEQLIQKSEP 6316
+I LI K P
Sbjct: 772 IITKTAHLITKESP 785
Score = 35.4 bits (80), Expect = 2.0
Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)
Query: 6572 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6631
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 1451 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1505
Query: 6632 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6690
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q F
Sbjct: 1506 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1565
Query: 6691 Q 6691
+
Sbjct: 1566 E 1566
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 2248 bits (5826), Expect = 0.0
Identities = 1817/6606 (27%), Positives = 3154/6606 (47%), Gaps = 580/6606 (8%)
Query: 733 LKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDT-----------SMEESLKHLIAKGSMFD 781
LK KD++K E+ ++ Q+++++ S+ ++ LI K
Sbjct: 2339 LKKVKDIQK-----ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2393
Query: 782 ELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVS 841
+L ++++ LQ ++ S ES Q L AK AA K +D +
Sbjct: 2394 QLCSKTQASLQESLEKHFS-ESMQEFQEWFLGAK----------------AAAKESSDRT 2436
Query: 842 PDLDI-RLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
D + K+ + Q L+S + Q L G+ + H I+S+ + + KA
Sbjct: 2437 GDSKVLEAKLHDLQNILDS-VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE--QITKAN 2493
Query: 901 EELKNNVTEDIKMSLEEKSRDVCAK----WESLHHELSLYVQQLKIDIEKGKLSDNILKL 956
EE + + + +K ++++ CA +E H +L+L++ +++ L ++ +
Sbjct: 2494 EEFQAFLKQCLK---DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHI 2550
Query: 957 EKQINKEKK-------LIRRGRTKGLIKEHEACFSEEG---------CLYQLNHHMEVLR 1000
++ N+ K L+ + + + SEEG C L H +LR
Sbjct: 2551 PEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLR 2610
Query: 1001 ELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTS------------ 1048
E+L S + + L++ Q + +K + + T G
Sbjct: 2611 MTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDI 2670
Query: 1049 ---KNEGTITTSENRGGDPHSEAPFAKSDN---QPSTEKAMEPTMKFSLASVLRPLQEES 1102
K EG + + G + K Q E E +SV ES
Sbjct: 2671 LLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES 2730
Query: 1103 IMEK--DYSASINSLLERYDTYRDILEHHLQ-----NNKF----RITSDFSSEEDRSSSC 1151
++ + DY N L + ++ +EH LQ KF + S S ED + +
Sbjct: 2731 VISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL 2790
Query: 1152 LQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLN 1211
+ ++ + D +K+ LK + NDI KE+ R+++ +
Sbjct: 2791 HRLIAKSRELYEKTEDESFKDTAQEELKTQ--FNDIMT--------VAKEKMRKVEEIVK 2840
Query: 1212 TRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQ 1271
+ L+ V + + L + LH+ + + ++ + DS
Sbjct: 2841 DHLMYLDA-------VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIG 2893
Query: 1272 IEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLAS 1331
+R+E V + M + + ++ V +++ L+ L +A
Sbjct: 2894 ASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA- 2952
Query: 1332 LRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD------KCLKMLD 1385
LS + + A Q ++ + +K ++ L++ K + K ++LD
Sbjct: 2953 -----LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILD 3007
Query: 1386 MSFKDAERGDDTSCE-NLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQ 1444
K R +D + N L FS LS T+ V E N L C+ + Q
Sbjct: 3008 ALQKAEPRTEDLKSQLNELCRFSRDLS-TYSGKVSGLIKEYNCL---CLQASKGCQNKEQ 3063
Query: 1445 DVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT 1504
+Q + K A + ++ L+ + + +++ E++ SL ++ ++
Sbjct: 3064 ILQQRFRK---------AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3114
Query: 1505 VNQQCQNTVVLWENTKALVTECLEQC-GRVLELLKQYQNFKSILTTLIQKEESVISLQAS 1563
N Q + ++L + E+ G ++ +++K+ + L QKE ++
Sbjct: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESAL------ 3168
Query: 1564 YMGKENLKKRIAEIEIVKEEFNEHLEVVDK---------------------INQVCKNLQ 1602
ENLK ++ + E+ E + L +K + V + +
Sbjct: 3169 ----ENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIH 3224
Query: 1603 FY---LNKMKTFEEPPFEKEA---------NIIVDRWLDINEKTEDYYENLGRALALWDK 1650
Y LN++K + +E +A + + ++L ++ T++ L R +A ++
Sbjct: 3225 CYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQ 3284
Query: 1651 LFNLKNVIDEWTEKALQKMELHQLTEEDRE-------RLKEELQVHEQKTSEFSRRVAEI 1703
+ +W A+ ++ + D+ +L+ L V ++K + V
Sbjct: 3285 FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRG 3344
Query: 1704 QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA-LSGSTAELREDLDQAKTQIG 1762
+ +LQ++ P + ++ + + + L+ C + L G+ ++ D + G
Sbjct: 3345 ESVLQNTS-PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3403
Query: 1763 MTESLLKALSPS--------DSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTP----- 1809
+S+ L+ S D + K + + +++L + +E + +T
Sbjct: 3404 WMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQ 3463
Query: 1810 -ELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQ----CKNFNDWFSNIKVNLKECFES 1864
EL +L+++Y ++ + K++V + L+ + K F W + L +
Sbjct: 3464 LELQDLQERYRAIQE--RAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVL 3521
Query: 1865 SETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFEL 1924
+ E L+ L + + ++SVL H ++ + + + + ++ L
Sbjct: 3522 EGDAHTHETTLRDLQELQVHCAEGQAL--LNSVL-HTREDVIPSGIPQ------AEDRAL 3572
Query: 1925 EKMESICQARAKELEDSLQQL------LRLQDDH-RNLRKWLTNQEEKWKGMEEPGEKTE 1977
E + QA L ++ Q LRL + + + +WL EEK
Sbjct: 3573 ESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRA 3632
Query: 1978 LFCQALARKREQFESVAQLNNSLKEYGFTEEE---------EIIMEATCLMDRYQTLLRQ 2028
L + ++ E V + ++E G +E + +AT L RYQ LL Q
Sbjct: 3633 TKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQ 3692
Query: 2029 LSE----IEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIK 2084
+ E +EEE + L + S + + W ++ + + K+ +K+K
Sbjct: 3693 VLEQIKFLEEEIQSLEESESSLSSYSD----WYGSTHKNFKNVATKIDKVDTVMMGKKLK 3748
Query: 2085 EI-ILLKP--EGDARI-------ETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYL 2134
+ +LLK +G + + E +K E EA ++K + D Q
Sbjct: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEH 3808
Query: 2135 SHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQD 2194
EK L +++ + L + E ++ + L EKKAQL YK +
Sbjct: 3809 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLS 3868
Query: 2195 LTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSY 2254
+K ++ +G LLE ++ + ++ +++ ++ L ++ V +L+ V++H+ Y
Sbjct: 3869 HEPSVKSVREKGEALLELVQDVTLKDKID-QLQSDYQDLCSIGKEHVFSLEAKVKDHEDY 3927
Query: 2255 QVCVTDLNTTLDNFSKEFVS-----------FSDKPVDQIAVEEKLQKLQELENRLSLQD 2303
+ ++ L S V+ + + A+ E++ ++ N L ++
Sbjct: 3928 NSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKG 3987
Query: 2304 GTLKKILA--LAKSVKQNTSSVGQKIIKDDIKSL----QCKQKDLENRLAS------AKQ 2351
TL A L +KQN + Q KD ++ Q + LE+ L Q
Sbjct: 3988 DTLIGQCADHLQAKLKQNVHAHLQGT-KDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
Query: 2352 EMECCLNSI--------------------LKSKRSTEKKGKFTLP----------GREKQ 2381
+ + L+++ +K R+ +++ + L K
Sbjct: 4047 QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
Query: 2382 ATSDVQESTQ----ESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVN 2437
D+Q++ Q + + L + WE K E+ + Q + ++MK E ++N
Sbjct: 4107 TAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELN 4166
Query: 2438 ELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPL-EQTECLNKTETGALVLHNIGY 2496
QN + +++ +L++K+A++ + E+ L K E
Sbjct: 4167 IAQNM------------VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHL 4214
Query: 2497 SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVT- 2555
+ Q LD L + L +E RD+ + + VE ++ T+ ++L +S
Sbjct: 4215 NDQWLD-LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAV 4273
Query: 2556 YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQ 2615
+L+ +KK ++++ K ++ +LK + + + H+ DK+L++ Q LE W Q+E I+
Sbjct: 4274 HLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK 4333
Query: 2616 KKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS--PEERAGNQSM--IALTTD 2671
+K V +E + ++ Q+ ++QQ ++ LK P + A N M +A+ ++
Sbjct: 4334 RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
Query: 2672 LQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKC- 2730
L+A + L A+ M + G E++ ++ +++ + L L + + K
Sbjct: 4394 LEAKQMLLKSLIKDADRVMADL-GLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKAL 4452
Query: 2731 DIRNKMKETILWAKNLLGE------LNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
+ + + A + + + I LLPDD+ Q++ CK + Q V
Sbjct: 4453 SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTG 4512
Query: 2785 LAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIR 2844
L + ++ + +T E S++ L++L++ Y ++ K + R Q+LE L R +F
Sbjct: 4513 LWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFD 4572
Query: 2845 KFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEE 2904
K +++++ + P + +EL + ++ E ++ + T + I
Sbjct: 4573 KACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS 4632
Query: 2905 LNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQR 2964
LN + +L ++L L + N I ++ +V+ I +++ + ++
Sbjct: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4692
Query: 2965 NELLLNQEVNKGVKEEIYNLKDRLTAIKC-------CILQVLKLKKVFDYIGLNWDFSQL 3017
L +++ EE +L+D AI + ++ + K+ F G W ++
Sbjct: 4693 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKM 4752
Query: 3018 DQLQTQVFEKEKELEEKIKQLD----TFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAP 3073
L T +++ E+++ L+ ++E Q L +++++ + K+ E L A
Sbjct: 4753 LHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAE 4812
Query: 3074 DSSPESRRLNAQILSQRI--EKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEEND 3131
+ L + I ++ +++ L D EK QI+ E
Sbjct: 4813 EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHL------DPLAYEKARHQIQSWQGELK 4866
Query: 3132 KLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
L + V E + + + Q ++ SL L ++K++L P+ ++L ++ IQ E
Sbjct: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRK 4926
Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSE--ASDVETKLREFEDLQMQLNTSIDLRTN 3249
+ QE+V + + + A++ EK++ + E ++D+E L E +L + ++ R
Sbjct: 4927 IQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQA 4986
Query: 3250 VLNDAYENLTRYKEAVTRAVESITSLEAII--IPYRVDVGNPEESLEMPLR---KQEELE 3304
L + Y RY + A + + + ++ +DV + EE+L+ + +++
Sbjct: 4987 TLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFH 5046
Query: 3305 STVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCY 3364
S + + L L + P K L+ + L ++ M AQ +R + Y
Sbjct: 5047 SNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5106
Query: 3365 RKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQIL 3424
+K E++ ++ E L + S EA E+L + KALVS + S E+++ L +
Sbjct: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEE-- 5164
Query: 3425 RLLRLRCTENDG--ICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREA 3482
+ +L T ND L + ++ +W++W L A++ E E+ EW + ++++
Sbjct: 5165 KASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT 5224
Query: 3483 IILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542
++D LQ++LP + E A+ EL LL+ + +E+QQ L +L Q+ S+
Sbjct: 5225 EMIDQLQDKLP--GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDG 5282
Query: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
+ E P QEIT+M++RC + +KV+ N +LV+ E+++R +I ++K + Q+T
Sbjct: 5283 AAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQET 5342
Query: 3603 TTSFQNMAFQ----------------DHPEKSEQFEELQSILKKGKLTF----------- 3635
N + +H + E+ E Q G T
Sbjct: 5343 KEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5402
Query: 3636 --------ENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKIS----NEVLKSS 3683
+ I +K IK E E+ Q+++ K L I K+ N V +
Sbjct: 5403 VALDLKIRDQIQDK--IKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT 5460
Query: 3684 PSYAMRRKIEEINNGLHN----VEKMLQQK-------SKNIEKAQEIQKKMWDELDLWHS 3732
+ +++ N+ L V+K L+Q +K I K E+ ++ + + S
Sbjct: 5461 DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS 5520
Query: 3733 KLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSD 3792
KLN+ S +++ E +W++ + + ++ R + T+ +EE +
Sbjct: 5521 KLNQAASHLEEYNEMLE-LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL-LEESKE 5578
Query: 3793 LLKSTEAWIENTSHLLA-------NPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIF 3845
+ EA E +L + + + R +++ L++ + +
Sbjct: 5579 IDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
Query: 3846 MDLEDLSIIFETDELTQSIQE-----LSNQVTALQQKI--MESL-PQIQ---------RM 3888
+L+ L E + T + E L Q++ Q + MESL P++Q R+
Sbjct: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRI 5698
Query: 3889 ADDVVA----------IESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILE--- 3935
+DVVA ++ E ++ + I+ + + E+ +KH + ++E
Sbjct: 5699 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5758
Query: 3936 -----------NIRPMKKTIA-------EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDI 3977
NI+ ++ I+ +I YQ ++ + K L + + +L +
Sbjct: 5759 REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
Query: 3978 KLLENVTQEQNELLKVVIKQTNEWDEEIEN--------LKQILNNYSAQFSLEHMSPDQA 4029
+E + + +L ++ + + L + + + +S A
Sbjct: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
Query: 4030 DKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSE 4089
+ P + Q ++ Q L+ +H QE E P+ T++
Sbjct: 5879 CRSPSPVANTDASVNQDIAYYQALS--AERLQTDAAKIHPSTSASQEFYEPGLEPSATAK 5936
Query: 4090 EGGVA------ERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSL 4143
G + + SE++ ++ ++ ++ S K + + K SP+ S
Sbjct: 5937 LGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS- 5995
Query: 4144 WKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQT-- 4201
+ M E +A ++Q+ +I+ +S+A+ L +S + + +L+ T
Sbjct: 5996 --PESQMAEHQALMDEILMLQD---EINELQSSLAEELVSESCEADPAEQLALQSTLTVL 6050
Query: 4202 -EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
E +T ++A + L ++E+ R E + L + + EL+ WL ++
Sbjct: 6051 AERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--QALQRYRCEADELDSWLLSTKATLD 6107
Query: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETC---KDQGLGDNGATQHEAEALSL 4317
+E QL+ CQ ML EIE KV L E ++ L T+ EAE L+
Sbjct: 6108 TALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAG 6167
Query: 4318 KLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFS 4377
KL+ +K +L ++Q L +K Q K+ S+ + P L T Q
Sbjct: 6168 KLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ-Q 6226
Query: 4378 RQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDV 4437
RQ QQQ+ LE + EQK ++ + +++ Q+ + T+ ++ S E +
Sbjct: 6227 RQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAE--TSGDAGEKPDVLSQELGM 6284
Query: 4438 PDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQ----VSTNMGILPSVTMYNFRYP 4493
S + Q KW+ LH E S+K KL L + Q S +L V +Y P
Sbjct: 6285 EGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVP 6344
Query: 4494 TTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
T ++ T+ L+ L Q + +Q + I+L++KL++ S L VEE L +
Sbjct: 6345 TQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFV 6403
Query: 4554 PR-LYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQV 4612
L E+ + E LA ++K++ + K +A G+N +++ + L
Sbjct: 6404 ATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 6463
Query: 4613 CLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQL 4672
L + R +K L ++QN++K L+ L +K + Q L + Q VAEQ+
Sbjct: 6464 RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 6523
Query: 4673 QKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSS 4732
+ L+ ++ + +L+ G++L + +QE+ KL+D+ D + ++ +R + L+
Sbjct: 6524 EAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQ 6583
Query: 4733 PFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLL 4792
+SQ + LQ + +L++ G+EK+A SK +Q ++ HK +FQ L + M+L
Sbjct: 6584 NLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMIL 6643
Query: 4793 IQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEK 4852
+ KI+ +Q F E + + + +++ + G++L+ +L+ W DE+ L +
Sbjct: 6644 TETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR 6703
Query: 4853 DLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCP 4912
LE++ S++PSV LVEE E+RL++RI+ YQ +K ++ +LYQ L++GK+L+ S+SC
Sbjct: 6704 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6763
Query: 4913 ELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972
+LE Q+ +L E WLS K+ ELHRL+ +LKH Y +S L WL+S++ L +W +
Sbjct: 6764 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ 6823
Query: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQ 5032
QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V+S GNQLL LK+ DTATLR+ L++
Sbjct: 6824 QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSR 6883
Query: 5033 FEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS-DEDSVHSPSSA 5091
+ +WT L+T +P +QEKLHQLQM+KLPSR AI+E++SW++ +E+ DED++ +
Sbjct: 6884 IDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943
Query: 5092 SQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
+ LQK+K F+++++ KQ VDFVNQS+LQ+S+ DVESKR ++T+FAE LG MN+ W
Sbjct: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003
Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
+ G++ KIQ LE LLES +E EN +Q L W E QE+RLK + SVQ L D
Sbjct: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKD 7063
Query: 5212 CQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKT 5270
CQD+E+ + K K +++++Q+ L L ++ + S + EL Q +++ V QLK
Sbjct: 7064 CQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKI 7123
Query: 5271 SMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESS 5330
++SVL +W + +D++N + Y + + + SLE ++ QV+NLQ+LQD+ E
Sbjct: 7124 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 7183
Query: 5331 EGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389
E S +K + +L C P V E + + + RW + + IA+QLQ +++LLQLW+
Sbjct: 7184 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 7243
Query: 5390 YSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQN 5449
Y + + A+ ++QQE + +L + + + + + +QD +L + K++
Sbjct: 7244 YKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFL 7303
Query: 5450 SSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLES 5508
+ ++L Q ++S + SL Q LE+ L + + + ++ F LE+
Sbjct: 7304 HELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEA 7363
Query: 5509 LKGLIMHEEENL---DRLHQQE----KENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLS 5561
L+ I+ EE L D H + +E + +L ++ +PD++ LNE+ +LPL+
Sbjct: 7364 LEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLN 7423
Query: 5562 DVAVKTLQNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEALKVDV 5620
D +K +QN+NR W ++ ER S+LQ L ++ FL CE W++ L + E+ L V++
Sbjct: 7424 DKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483
Query: 5621 ANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
+ + LLEQQ+ +++ +AE+ Q I S + +LL+ ++++R EF + + L+++
Sbjct: 7484 SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQ 7543
Query: 5681 WQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSL 5740
WQ ++ +QR+G +D +RQWQ + E L ++L + S+L + G L Q R+L
Sbjct: 7544 WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL 7603
Query: 5741 IHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAE 5800
E++ KE F R++ + LT+EAG++LLL+ D + ++ ++++Q+ WK +L E
Sbjct: 7604 FDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE 7663
Query: 5801 MIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLAS 5860
K+ ++ W++CEK I + +L+ K + LP+ HE+LH E+ KELE ++ S
Sbjct: 7664 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
Query: 5861 WTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWV 5920
WT +L +L +K L+ ++ +D+ +L E++E L RQWE+LC ++++R+Q+I +RLN W
Sbjct: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
Query: 5921 VFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQL 5980
VF+EKNKELC WL QME+KV Q DI IEEMIEKL+KD EEI + ENK+QL+QMG++L
Sbjct: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
Query: 5981 IKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLAR 6040
KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET +QQLDKNMS+LRTWLA
Sbjct: 7844 AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 7903
Query: 6041 IESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE 6100
IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD DACA +
Sbjct: 7904 IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7963
Query: 6101 TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAA 6160
ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+ERTAA
Sbjct: 7964 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 8023
Query: 6161 CPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVH 6220
P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A LKQMVH
Sbjct: 8024 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 8083
Query: 6221 EGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD 6280
EGNQRWDNLQ+RVT++LRRL+HF QREEFE R+SILVWLTEMDLQLTN+EHFSE D
Sbjct: 8084 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8143
Query: 6281 DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV 6340
K++QL FQQEI+LN NKI+Q+I GEQLI+KSEPLDA +IE+EL+EL RYCQEVFGRV
Sbjct: 8144 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 8203
Query: 6341 SRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQSLCHL 6396
R+H++L P +DE + S+ E ++ED + W R S +PSS SL
Sbjct: 8204 ERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLA 8262
Query: 6397 VAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSAL--SDVEIPENPEA 6454
ERSG +TP SVDSIPLEWDH D+ D E AL D E ++ +
Sbjct: 8263 QPLRSERSGRDTPASVDSIPLEWDHDYDL------SRDLESAMSRALPSEDEEGQDDKDF 8316
Query: 6455 YLKMTTKTLKASSGKSISDGHSWHVPDSPSCPEHHYKQMEG-DRNVPPVPPASSTPYKPP 6513
YL+ + S S + + + +Q E R+ P P T YK
Sbjct: 8317 YLR---GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK-- 8371
Query: 6514 YGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------QQSGAFDRWEMIQAQELH 6567
G + L + + L ++E+ L G Q +G DRWE++QAQ L
Sbjct: 8372 -GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALS 8430
Query: 6568 NKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 6624
+L++KQNL QQ NSD+++I WL TE ELE L+ + +DIQ IEL++K+L+E+ K
Sbjct: 8431 KELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK 8490
Query: 6625 AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLM 6684
A D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+ ++ WRG L+ +LM
Sbjct: 8491 AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 8550
Query: 6685 QCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 6744
QCQ FH++S LLL L + R+ + D D L + ++LMQ++ EL+E Q +V
Sbjct: 8551 QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
Query: 6745 MLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNPAS 6798
LQ++S LL+ G DC+EA+EKVHVI +LK L ++VS + L+ + +Q S
Sbjct: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 8670
Query: 6799 PLPSFDEVD-SGDQPPAT-----------------SVPAPRAKFRAVRTTEGEEETESRV 6840
S DE+D SG P + S P P R+T+G ++
Sbjct: 8671 SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSE 8730
Query: 6841 PGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRY 6900
PG R R FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PMLRY
Sbjct: 8731 PGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRY 8790
Query: 6901 TNGPPP 6906
TNGPPP
Sbjct: 8791 TNGPPP 8796
Score = 608 bits (1569), Expect = e-173
Identities = 1245/6222 (20%), Positives = 2449/6222 (39%), Gaps = 953/6222 (15%)
Query: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
LQ EQE QK+ FT WINS LA+ P V+ DLF D+K G LL LLEVLSGQ+LP ++G
Sbjct: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
Query: 85 SNTFQCRI--NIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
+ NI AL FL R IKL+NI+ TDI DG PSI+LGL+WTIIL+F IE+L
Sbjct: 81 RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140
Query: 143 TL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESV 201
L S V + SS SPP+K+ KV + Q +A+KALL W Q +
Sbjct: 141 NLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYTAGKQTGI 198
Query: 202 NVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEP 261
V DF SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL IPRLL+P
Sbjct: 199 EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258
Query: 262 EDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK----------- 310
EDVDV PDEKSIMTYVAQFL++ D + Q + G+ +
Sbjct: 259 EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318
Query: 311 --EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDEL 359
++++ ++ E D KY S F + ++K ++ +L
Sbjct: 319 IFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKL 378
Query: 360 DKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQA 419
D ++++WD + ++ W I+L+ +LP PL AWL E + E+++ Q H +
Sbjct: 379 SLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEET 438
Query: 420 VTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRINNI--LEK 476
IQ K+ K L+ + H + + N +P VPP++LE+M R + + +
Sbjct: 439 ANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFHFVSSTSE 497
Query: 477 KFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLD 536
++ +EF K +L L+ +SKL W IKYG RESVE LL+++ FIE +F + +
Sbjct: 498 LHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYE 557
Query: 537 TSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQKVLACWAT 590
++Q + E+Y G + + +R + +V+S L++V++ W
Sbjct: 558 VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDR 617
Query: 591 YVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGS 645
Y + L+A E+ +K E K+ F L W +H +N+AGNFL+E +++V
Sbjct: 618 YGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSR 677
Query: 646 SISKELRRLNKRWRKLVSKTQ------------------------------------LE- 668
+ ++L LN RWR+L + + LE
Sbjct: 678 DLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEV 737
Query: 669 --MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEK 721
MN+ L+I+ +Q P D I++K + S E E + K E+
Sbjct: 738 SFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFATMSKLKEQ 795
Query: 722 HEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESLKHLIAKG 777
K E ++ L + ++L+ +E E + S D +++ T +E +
Sbjct: 796 LTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFK 852
Query: 778 SMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI---NVV 828
EL+A E+ +++ Q++ + +VL Q ++Q + + ++V
Sbjct: 853 QKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMV 912
Query: 829 KLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIIS 888
K K V + + K EES+ ELE + AQ+ L ++ P EL+ +H E
Sbjct: 913 KKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQL 970
Query: 889 NTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGK 948
+ + L +LKA +EL + + E + L+E R + +W+ L E ++ LKID+EK +
Sbjct: 971 DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNR 1030
Query: 949 LSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS 1008
++ + ++++E KL+ + ++ +IKEH FS++G + ++++ ELC +LP
Sbjct: 1031 FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPV 1090
Query: 1009 QKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP 1064
+ ++ LK+ I+ + E + S+ I+T+E +
Sbjct: 1091 RDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGI 1150
Query: 1065 HSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIMEK--DYSA 1110
EA + N ++A+E T+ + S VL + E+ +K D A
Sbjct: 1151 KGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELA 1208
Query: 1111 SINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARW 1170
++S + T +E L N C+Q K +++KN +
Sbjct: 1209 KLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVKNSLE--- 1246
Query: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKA 1230
E+IS KE + + + L+T E+L A +L+L ++
Sbjct: 1247 ---ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQLLLHHQQK 1281
Query: 1231 SLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288
+ + + + Q DR ++ LR ++ ++ R E L++
Sbjct: 1282 TKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRK 1341
Query: 1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348
F+ + + +++Y Q G +H S +L++L L + E + + +
Sbjct: 1342 WERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
Query: 1349 DTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSI 1408
+ A E L +NK+ L++ +AK + + +K L +DT E++ +
Sbjct: 1399 LVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEEDIKTMEMV 1444
Query: 1409 KLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAV 1463
K H +G E TE+ K L N L + + QIS+I + T+ +
Sbjct: 1445 KTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV---TIQEI 1493
Query: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523
+ + S++ L+E A S F E + + +
Sbjct: 1494 ESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREH 1539
Query: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEE 1583
+CLE G +L L Q Q F+ L + ++SV + + E V +E
Sbjct: 1540 AQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATETYKVLQE 1594
Query: 1584 FNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGR 1643
+ + ++ ++ F + K +EA + ++ DI + ++ L
Sbjct: 1595 HMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652
Query: 1644 ALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSEFSRRVAE 1702
LA W +L + W E+ K ++ DR +++ ELQ+ + +E + +
Sbjct: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
Query: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQ-AKTQI 1761
LLQ E + + + K+ H+++ E DL Q +I
Sbjct: 1713 YSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLPQIINKRI 1757
Query: 1762 GMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYES 1820
+S++ D L + F+ ++ LQ + ++++Q+ L + +
Sbjct: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--------LTRHKDH 1809
Query: 1821 VSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878
+++ + K + LQ H +KL D ++ ++CF+ E V ++ Q
Sbjct: 1810 AAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQVVERRQLA 1866
Query: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKEL 1938
L + ++ H + + + V + K ES K+L
Sbjct: 1867 LSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES--DLIEKDL 1909
Query: 1939 EDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQFESVAQLN 1997
D+LQ L+ +L L+ + K G E L + E+ +++
Sbjct: 1910 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1969
Query: 1998 NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI 2057
S E + + + D+ + LL+ + +IEE T+ + +
Sbjct: 1970 QS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPTR------ 2011
Query: 2058 KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLT 2117
+ +++ L V N E ++ E E+ LK + + Q + + AP V + +
Sbjct: 2012 QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAPEVDREIN 2061
Query: 2118 DISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEA 2167
+ WD+T L + + L K L++ + + +K +++
Sbjct: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL 2121
Query: 2168 GFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWL 2224
+A +H + K + K F K + L S LK++ S L++ + + WL
Sbjct: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV--DKWL 2179
Query: 2225 EI-KHLHESL---------------------------LQQLQDSVQNLDGHVR------- 2249
++ + L E++ + Q+ +++ NLD H+R
Sbjct: 2180 DVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKE 2239
Query: 2250 ---EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTL 2306
E + + + +L++ +++ + + P Q + +QKL+ + + GTL
Sbjct: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTL 2299
Query: 2307 KKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASAKQEMECC 2356
K A + V++ + + K + + C Q KD++ L S + +
Sbjct: 2300 KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISST 2359
Query: 2357 ---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
LNS+ + S E + T ++ +A S + TQ S E LE+ + +
Sbjct: 2360 QENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHFSESMQEF 2418
Query: 2411 VEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ-----LEEIEKL 2461
E + + + A+ES T D E K+++LQN LD++ + +E + L
Sbjct: 2419 QEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAVTQEGQTL 2473
Query: 2462 YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
Y L + I Q + E L Q L + L + +
Sbjct: 2474 YAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLW 2530
Query: 2522 LRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKW 2581
+ + +E + + L K+ + + + K++ F+ + ++SL L +
Sbjct: 2531 IHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESLDKLSQRG 2581
Query: 2582 ENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
+ LS H + +L QL + + + ++K V E L +Q
Sbjct: 2582 QLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQ--- 2634
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKE- 2698
S+ + +Q RL E G++ + + ++KG+ E+++ G+ E
Sbjct: 2635 -SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNMAIGKGEQ 2690
Query: 2699 --KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPL 2756
+ + ++G ++ Q ETL+ +WA + ++ L
Sbjct: 2691 ALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSSVHAQSTL 2728
Query: 2757 LPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDLNNTLEDL 2811
+ ++SQ + + R+ +E E V K+ P E L + L+ +
Sbjct: 2729 --ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSI 2779
Query: 2812 RNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEA 2868
++ + + + +S++L K E+ S F + +L Q ++ + + + + E
Sbjct: 2780 LSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKEKMRKVEE 2837
Query: 2869 ELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKNLKIRTNR 2926
+K H + L+A + + S L +++ + + ++ +++ + + +I +R
Sbjct: 2838 IVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASR 2896
Query: 2927 IQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEVNKGVKEE 2980
+ R +++ EV+ C H + AL+ + DS+ + + L V++ E
Sbjct: 2897 LSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955
Query: 2981 ------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQLQTQVFE 3026
+ L+ L + L +L+ K + I W Q LD LQ +
Sbjct: 2956 QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQ-KAEP 3014
Query: 3027 KEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAPDSSPESR 3080
+ ++L+ ++ +L F + GK L+ + + LQ K + + R
Sbjct: 3015 RTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFR 3074
Query: 3081 RLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNM 3140
+++ +I AKC +I + ++E T K +E L N + + +
Sbjct: 3075 DFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNMMLSKGEL 3130
Query: 3141 VLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDNCEAFQEQ 3198
+ L KE K Q K+ + S L Q L NL+I+ +++ + + E Q+
Sbjct: 3131 LSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVSAEPIQD- 3187
Query: 3199 VWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYE-N 3257
W ++ EK E+S+ D+ K RE + LQ L YE
Sbjct: 3188 -W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI---------HCYEPQ 3229
Query: 3258 LTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLT-EK 3316
L R KE + E + ++ + +L S + +LT EK
Sbjct: 3230 LNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLALSNLTKEK 3271
Query: 3317 LGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRKMEEDIYT 3373
+ L +V++++ K + T+A L++Y C+ ++ +
Sbjct: 3272 VS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPTSDKSVLD 3317
Query: 3374 NLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433
+ +L L EAL ++Q K + +I T+ E + L+ T
Sbjct: 3318 S------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV----------LQNTS 3352
Query: 3434 NDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEEL 3492
+GI + + + ++ + W SLL A + E +W + + + + +D+++ L
Sbjct: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
Query: 3493 PEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVP 3552
E + + +EL D G K +LL +L ++ + E GA T
Sbjct: 3413 NE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVKGAGMTE- 3458
Query: 3553 AFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQ 3612
+T ++ LQ +Q+ +Q +E + +++++ L +Q+ +F+ Q
Sbjct: 3459 --HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQ 3510
Query: 3613 DHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
+ EK +Q+ L+ + T ++ E L++ +E ++ + + ++ + + +
Sbjct: 3511 EQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Query: 3673 EKISNEVLKSSPSY-------------------AMRRKIEEINNGLHNVEKML-----QQ 3708
++ + + +Y M +K ++++ L E+ + +Q
Sbjct: 3569 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQ 3628
Query: 3709 KSKNIEKAQEIQKKMW-DELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQ 3767
++ ++ Q Q K W +E+ + ++ E+ + Q+I+++ ++ + +YQ
Sbjct: 3629 SNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQ 3687
Query: 3768 QVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHA 3824
+ + + L + +EE L S W +T N A D + T +
Sbjct: 3688 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3747
Query: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIME 3880
T+++ L+D E+ H+LL S + + ++ + E + L + I + Q+ L + +
Sbjct: 3748 KTLEVLLKDMEKGHSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
Query: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
+++ + K++ + +++ + IL E P+ L + L + +
Sbjct: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSL 3862
Query: 3941 KKTIAEIVSYQVELR-LPQTGMKPLPVFQ------RTNQLLQDIKLLENVTQEQNELLKV 3993
++T ++S++ ++ + + G L + Q + +QL D + L ++ +E L+
Sbjct: 3863 QQT---VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEA 3919
Query: 3994 VIKQTNEWDEEIENLKQILNNYSAQF---------SLEHMSPDQADKLPQLQGEIERMEK 4044
+K +++ E++ +++ L S + SLE ++ A ++ EI E
Sbjct: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME-EIAGFED 3978
Query: 4045 QILSLNQRKEDLLVDLKATVL------NLHQHLKQEQEGVERDRLPAVTSEEGGVAER-- 4096
++ +L Q K D L+ A L N+H HL+ +D A+ S A+R
Sbjct: 3979 RLNNL-QMKGDTLIGQCADHLQAKLKQNVHAHLQG-----TKDSYSAICS----TAQRMY 4028
Query: 4097 DASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRAS 4156
+ E +L + S ++ +++ EPSPQ S + K ++ RA
Sbjct: 4029 QSLEHELQKHVSR------QDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL 4082
Query: 4157 SSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDS 4216
+ + N+ + D TEQ E L ++A L
Sbjct: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL------------VQAQNL-- 4128
Query: 4217 SDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQV 4271
QG E + K+ + + L K + +ELEL N+A + D +
Sbjct: 4129 --TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELEL-----NIAQNMVSQVKDFVKK 4181
Query: 4272 LEQQLVGCQAMLTEI----------EHK-VAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
L+ + ++ ++ EHK + L + D N E L
Sbjct: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRD 4241
Query: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
C + V++ L++ +E + S H EAL+ + L+ + ER
Sbjct: 4242 YHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALA-----LQERKYAIEDL 4295
Query: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
Q+Q+++E ++ K+ +K + ++ W Q D + + + E +V S
Sbjct: 4296 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL----EDLIKRKIQVSVTNLEELNVVQS 4351
Query: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
+ Q +W E I L Q P ++ N+
Sbjct: 4352 ----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQNL--------------------- 4383
Query: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
L D S L+ ++ + + + D+ + +L L Q + + D
Sbjct: 4384 ----LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
Query: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
GQ+ Y L ALS+K L+ + + +CL +
Sbjct: 4440 LVGQRRKY---------LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVS 4490
Query: 4621 AVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSKTSLQQSLNEISGQSVAEQLQKAD 4676
++ KS +A L ++YQNE+ L+ Q L+K T +Q +E+ G+ ++LQ
Sbjct: 4491 KQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEVT--EQEKSEVLGK--LQELQ--S 4541
Query: 4677 AYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVT 4736
Y L+ R+ +L L+ + ED D L+
Sbjct: 4542 VYDSVLQKCSHRLQELEKN---------LVSRKHFKED-FDKACHWLK------------ 4579
Query: 4737 ESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Q D + + L+ E H L + ++ + + EN +L +Q
Sbjct: 4580 --QADIVTFPEINLMNESSE--LHTQLAKYQNILEQSPEYENL----------LLTLQRT 4625
Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
ILPSL + ++ +E+ L RQ + + K+ + E + ++ +
Sbjct: 4626 GQTILPSLNEVDHSYLSEK------LNALPRQFNVIVALAKDKFYKVQEAILARKEYASL 4679
Query: 4857 LISTLPSVSLVEETEERL--------VERISFYQQIKRNIGGKHARLYQT---LNEGKQL 4905
+ T S+S +E R+ VE Q R I + A L + LN+ K+
Sbjct: 4680 IELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEG 4739
Query: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQH 4965
S P ++ L + L ++ + + L+ + + QL + L+S +
Sbjct: 4740 FRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799
Query: 4966 TLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT 5025
+ E++L + L S + D LK I + + HL
Sbjct: 4800 EQSKVNEETLPAEEKLKMYHSLAGSL------QDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
Query: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSV 5085
R + ++ + +L + + + + ++ + + ++ + W+ V+ + S V
Sbjct: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELS--GPV 4911
Query: 5086 HSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLG 5145
+ + ++ ++K + + E+ I++ ++ + T ++K + L
Sbjct: 4912 YLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFT---KAKELISADLEHSLA 4968
Query: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205
E++ + L + L ++ Q N+WLE +E L+ V S
Sbjct: 4969 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA 5028
Query: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQV 5265
++ L + + L+EL TL+ PL++ T ++L QK +S+ +
Sbjct: 5029 EENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTGK--EDLEQKVASLELRS 5082
Query: 5266 NQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
++ +Q +W Y + +EV +M E S S ++
Sbjct: 5083 QRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142
Query: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNT-HKRWTQVNQAIADQ 5376
++L S L+E +L+ ++ + T +RWT++ DQ
Sbjct: 5143 SEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5202
Query: 5377 LQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436
+ + + W ++N +A + Q + K + S L +L + EL+
Sbjct: 5203 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5262
Query: 5437 HDVQKTKEAFLQNSSVLD--RLPQPAESSTHM-----LLPGPLHSLQRAAYLEKMLLVKA 5489
Q S+L P P E M + L+ ++ K++ +
Sbjct: 5263 QQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQEL 5322
Query: 5490 NEFEFVLSQFK------------------DFGVRLESLKGLIMHEEENLDRLHQQEKENP 5531
+ E V +Q + +LE L+ L+ + + + +E
Sbjct: 5323 KDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK 5382
Query: 5532 DSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQG 5591
+ +L L ++ L EV+L L + D +Q+ ++ ++ AT+ E ++Q
Sbjct: 5383 EKYLGLYTILPSELS--LQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQIQ- 5435
Query: 5592 IGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK--------TYKMLEAEVSI 5643
K + L I LK N + +Q+ K++E + ++
Sbjct: 5436 ------------KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483
Query: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQ 5703
+ ++ Q+ QL +P + KLT+ Q ++ R ++ +
Sbjct: 5484 QK-----FLEQNGQL-------GKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5530
Query: 5704 DFTTSVENLFRFLTDTSHLL-------SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRT 5756
++ +E + +++ L SA + +E++ L+QT L+ E +KEI +
Sbjct: 5531 EYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQT--LLEE--SKEIDSELEAM 5586
Query: 5757 TCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCE 5816
T EKL T + E + +++++L +++ + ++ Q + + E
Sbjct: 5587 T--------EKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
Query: 5817 KKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKELIKELE 5855
++K+L++ L+ +A P L E L + + L+ E+E
Sbjct: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEME 5680
Score = 117 bits (292), Expect = 5e-25
Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)
Query: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
Y+ +K +LI +Q+ +I + Q + QK + + + + ++
Sbjct: 1237 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1296
Query: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
A+ + +GE LP +E+ KLE LD G+ R+R + VT + +
Sbjct: 1297 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1351
Query: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
+V+ + + +H S +L +++E K F ++ + + +QA + A +P
Sbjct: 1352 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1409
Query: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
QN++ + + +VK LE+ + ++ + KW+ F N+ +L EK+L
Sbjct: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
Query: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
L ++ ++ + ++E E +L E SF Q + + A+L Q
Sbjct: 1470 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1529
Query: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
G++L C LEG I LS +K + L ++Q S + D+L
Sbjct: 1530 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1577
Query: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
++ +K ++ +++ Q L+++ S I F +++V + S ++ Q
Sbjct: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637
Query: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
L KE TA L A + E++ + +T L + K +M+ R + +
Sbjct: 1638 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1697
Query: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
+ ++++ + S +S LLQ + +SL +++ D
Sbjct: 1698 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1730
Query: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
+ HL +++ +W + ++N++I L+ ++ + + + + W++
Sbjct: 1731 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
Query: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
L+T + S++ Q L +D ++ K L L+ L S + LL+
Sbjct: 1786 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844
Query: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
A +LF++ S V+ + + + LQ + ++ T+ M ++
Sbjct: 1845 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1903
Query: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
++ + L ++N ++L+ A S +G K Q + I Q T R
Sbjct: 1904 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1950
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
T + ++++ Q+LL KQ EA LA + + + E L
Sbjct: 1951 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1991
Query: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
+++DI+E + + T++A Q V ++L S H L +A + +
Sbjct: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2047
Query: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
+ A E + +++ + V + K LI HE + +L R +Q K L
Sbjct: 2048 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2103
Query: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
+ ++ I+ ++ + A + + T+ SEL+ I ++
Sbjct: 2104 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2163
Query: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
L +KW+ + EK+EE L+V ++ N +P++ E
Sbjct: 2164 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2223
Query: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
++ K E+EV + ++ L + T+ +E P+ + L
Sbjct: 2224 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2283
Query: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
+ ++A + KG + +DFT + +F+ D + L++ + +
Sbjct: 2284 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2336
Query: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
+L + + + EL++++ + + + C A + L +T +K E+V +
Sbjct: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2396
Query: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
S+ Q S ++ +E +E +++FQ K+ + +VL+A+ LH D
Sbjct: 2397 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2448
Query: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
L N + + + + L + TQ E QT+ A L++ + V ++EQI + +++
Sbjct: 2449 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2501
Query: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
+ KQ ++D + F +++++L W+ +ME + T ++ + +K+ + ++
Sbjct: 2502 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2560
Query: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
+F L ++ D+L + S + A + +L +++ Q+L + +++ +
Sbjct: 2561 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2620
Query: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
+ L++ + ++ W+ I+ L+ + ++KRL++ QD+ +
Sbjct: 2621 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2679
Query: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
+ + L S N+ IQ +L W +I + S+ + +E W
Sbjct: 2680 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2735
Query: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
+++ ++ E W++S ++ P + VL + L E R +H +
Sbjct: 2736 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
Query: 6192 QLELINKQYRRLARENRTDTA 6212
+ + Y + E+ DTA
Sbjct: 2796 K---SRELYEKTEDESFKDTA 2813
Score = 105 bits (262), Expect = 2e-21
Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)
Query: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
+ K T L ++ + SN E +L+ EL + E++L+
Sbjct: 1211 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1266
Query: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
L+ + +H++ + K++ D + + +A G + E L+ L
Sbjct: 1267 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1321
Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
+ + + + + ++ L ++ + + L ++ +S ++ L+ S +S++ +L++
Sbjct: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1381
Query: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
++ E+ + L E + L ++ ++V KLED L+
Sbjct: 1382 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1441
Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
M++ ++ S F T S V I +++ L+ + S A+ QI K
Sbjct: 1442 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1487
Query: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
V Q++ ++ ++ ++ + + ++T+++ E+ R+ L+
Sbjct: 1488 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1547
Query: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
L + ++F+EN +++ + + L + S ET + L E + Q ++
Sbjct: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1603
Query: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
+ + +++V SC + + A L++Q+ + ++ L+ LL H
Sbjct: 1604 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1660
Query: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
++ WLE + + +++S D + + EV ++S + ++
Sbjct: 1661 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1717
Query: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
+ L + + D ++ L Q +++W LP I K + + E+
Sbjct: 1718 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1773
Query: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
+ W+ E QT+ E S+ A L +HK+ E++ K+ + + L
Sbjct: 1774 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1827
Query: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
+L + + S+ ER + A HL E + + G+L +
Sbjct: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
Query: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
Q +E L++ E+ L+ L + LK + Q+
Sbjct: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
Query: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
+ +L + + I+N L K AL LK+++ + + +ED R D+ K
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
Query: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
+ + Q++ Q ++++QL DE+N + + +K + +V
Sbjct: 2008 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2056
Query: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
+ E E +W+ + +I + +G C + +++ E + + A++ L
Sbjct: 2057 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2102
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
+ A S++ + A K + AK + L N + G +L +E+
Sbjct: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162
Query: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
D ++ D++ T + +L S L DRL E ++ +P
Sbjct: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222
Query: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
++ +L L+K EFE S+ K+ +RLE L + +L L + + PD
Sbjct: 2223 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2273
Query: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
L + A Q +EH E++ K L D ++ Q N W +L
Sbjct: 2274 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329
Query: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
C++ NE CE K ++ ++K ++ + +++++ L + Y E E S+
Sbjct: 2330 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2378
Query: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
+ + QL T+ + FS+ +Q G + R GD
Sbjct: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2438
Query: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
L + D ++N+ ++D L AV QE +LY H K Q +
Sbjct: 2439 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2488
Query: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
T +A K L D + + + +D + + + EM ++F + E +
Sbjct: 2489 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2545
Query: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
++ I E K+ + ++ + L E + L +L+ E + +L T
Sbjct: 2546 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2605
Query: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
+L R + KE++ +VA+++ E E + + W
Sbjct: 2606 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2639
Query: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
+ +++++ + + ++ +EK + + + E +++L G+Q +++SNK
Sbjct: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2699
Query: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
I +L + + W D++ S V + I Q + + + L W+ ++ ++
Sbjct: 2700 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
Query: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
P+ + Q L E+ L ++ + E L+ S +TE +S
Sbjct: 2757 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2808
Query: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
+ T + L ++ +I ++ E+ K+EE + +LD F DWL SA+ +
Sbjct: 2809 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2868
Query: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
++ +++L + + R+I RL+++E + + ++ + + Q +
Sbjct: 2869 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2928
Query: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
++W++ L+ V+ + + F+ Q + E E L QLT +E
Sbjct: 2929 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2987
Query: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
+ D+++ + QEI +QK+EP L + +L EL R+
Sbjct: 2988 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3030
Query: 6334 QEV 6336
+++
Sbjct: 3031 RDL 3033
Score = 104 bits (260), Expect = 3e-21
Identities = 305/1616 (18%), Positives = 602/1616 (37%), Gaps = 271/1616 (16%)
Query: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLV--ASVSCPELEGQIAKLEE-- 4923
E E+ L +SF + K ++ YQ L + ++ A S E E + + E
Sbjct: 534 ESVEQLLQNYVSFIENSK--FFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETT 591
Query: 4924 -QWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDL- 4981
QW +L+ ++ L+ ++ + Y L WLE ++ LN QS N +D
Sbjct: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLN----QSENAKKDFF 647
Query: 4982 ---------DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL-------------- 5018
T ++ NF + + LK ++ + + L
Sbjct: 648 RNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMD 707
Query: 5019 ----KETD-TATLRASLAQFEQKWT-----------MLITQLPDIQEKLHQLQMEKLPSR 5062
+ TD TL A + +K + +LI L DI++++ + +
Sbjct: 708 RMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY---- 763
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
K IT+ + + ++ E+ ++ S++K L K KE + Y+ +Q L
Sbjct: 764 KIITKTA---HLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYE-------SQQL 813
Query: 5123 LQLSTCDVESKRYERTEFAEHLGEMN----------------RQWHRVHGMLNRKIQHLE 5166
L +E + T F + LG++N +Q H+ +
Sbjct: 814 L----IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTL 869
Query: 5167 QLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKAL 5226
L+E ++S K L+N L+ ++ Q + ++ Q ++ D + + S+ +
Sbjct: 870 TLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLM 929
Query: 5227 DELKQSYLTLESGAVPLLEDTASRID--ELFQKRSSVLTQVNQ----------------- 5267
+ ++S LE E + D EL ++ + +Q++Q
Sbjct: 930 KKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDIL 989
Query: 5268 -------LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
L+ +++ + ++WK L E + +E ++ + S+E R +++
Sbjct: 990 PEQEQQGLQEAVRKLHKQWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRE 1045
Query: 5321 QSLQDEAESSEGSWEKLQE--VIGKLKG---LCPSVAEIIEEKCQNT------------- 5362
L + EGS + ++E V KG LC ++IEE C
Sbjct: 1046 TKLMPQ----EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTC 1101
Query: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA 5422
H ++ AI +K WK Y++ E ++ + E + + + ++ N
Sbjct: 1102 HVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHG 1161
Query: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLE 5482
E+ + ++E+++ V K E S + RL E S+ L + +
Sbjct: 1162 EVK----RAVEEIRNGVTKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSF 1214
Query: 5483 KMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALT 5542
K L+ +E E +LS F D K ++ + E L ++ +E + L+
Sbjct: 1215 KALVTLLSEVEKMLSNFGD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFE 1270
Query: 5543 AQSPDIEHLNEVS-LKLPLSDVAVKTLQNMNRQW------------IRATATALERCSEL 5589
AQ + H + + DV + Q + + +T LER E
Sbjct: 1271 AQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRER 1330
Query: 5590 QGIGLN------EKFLYCCEKWIQLLEKI----EEALKVDVANSLPELLEQQKTYKM--- 5636
Q + E+F E ++ L + E L SL LEQ K +
Sbjct: 1331 QERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTE 1390
Query: 5637 ---LEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKG 5693
++AE + + Q+ QLL + + KL D + ++ + K
Sbjct: 1391 SIAVQAENLVKEASEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK- 1445
Query: 5694 DVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNKE-- 5748
+W F ++ E L ++T+ L+A++ + Q + I E+++K
Sbjct: 1446 ------TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS 1499
Query: 5749 -IHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQS 5807
+ + + A + GE + L G +L++ + +E + + Q Q
Sbjct: 1500 IVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGE---ELREHAQCLEGTILGHLSQQQK 1556
Query: 5808 TVETWDQCEKKIKELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
E + ++ + E + +L V +K S E ++ L +L + LE +L
Sbjct: 1557 FEENLRKIQQSVSEFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLS 1606
Query: 5867 ELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKN 5926
T + R V+ D V ++ L +Q+ED+ R R+ +E+ L W ++
Sbjct: 1607 SAITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1664
Query: 5927 KELCAWLVQMENKVLQTA-DISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMG 5977
WL + E K DIS + ++I+ LQ + + + + +S+ L Q+
Sbjct: 1665 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK----LLQLK 1720
Query: 5978 DQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTW 6037
+ L ++K + L ++++RW+ L +I R+ L+ A QQ D+ + + W
Sbjct: 1721 ESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780
Query: 6038 LARIESELSKPVVYDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNI 6086
+ SEL + D Q E++ + E Q LQ H A + S+
Sbjct: 1781 IKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRA 1836
Query: 6087 CDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYS 6146
D+ L A E ++ ++ ++RR + ++ +FL ++
Sbjct: 1837 EDLHLLQGKA---EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHA 1878
Query: 6147 RFEDWLKSAERTAACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYR 6201
L+ +T NS S+++ + L+ +A + L +
Sbjct: 1879 SLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLK 1938
Query: 6202 RLARENRTDTASRLKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESI 6257
+ E RT + Q+ E +R NL Q A+ + F +Q+EE + E I
Sbjct: 1939 IGSSEQRTSCRATADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI 1997
Query: 6258 LVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
E ++ + ++R N + E+ + +++ L +Q+ QK
Sbjct: 1998 -----EERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
Score = 90.9 bits (224), Expect = 4e-17
Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)
Query: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 6582 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6637
Query: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 6638 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6694
Query: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 6695 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6754
Query: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 6755 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6809
Query: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 6810 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6869
Query: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 6870 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929
Query: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
QK E +K + IH LQ G N +T + +S
Sbjct: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989
Query: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 7035
Query: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 7036 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7095
Query: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 7096 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154
Query: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214
Query: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
Query: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 7275 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7331
Query: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 7332 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7384
Query: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 7385 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7444
Query: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 7445 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7501
Query: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 7502 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7558
Query: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 7559 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7618
Query: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
+ + + L S LQ + I K + L + A L
Sbjct: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7672
Query: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7728
Query: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 7729 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7788
Query: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 7789 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7843
Query: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 7844 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7900
Query: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
L + E +E + I+ +C
Sbjct: 7901 LAHIE------------------------------------------SELAKPIVYDSCN 7918
Query: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7978
Query: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
R + I + E +IE + L QK L D S W + + + S
Sbjct: 7979 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
Query: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 8028 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 8070
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 8071 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
Query: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 8118 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8168
Query: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
+ + + + + II++++ L+ C + +R +K
Sbjct: 8169 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8211
Query: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 8212 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8268
Query: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
R + + PLE D L LE+ + P E E + +
Sbjct: 8269 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8317
Query: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
+ +G S H L + L K + ++ + + + + L T +
Sbjct: 8318 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 8376
Query: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
+ + +D +K+ +++E++SL ++ H T E+Q + WE
Sbjct: 8377 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 8423
Query: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
++ Q K Q + ++ +F + +N + DTE L+Q Q+ LQ+
Sbjct: 8424 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 8483
Query: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
+LK ++ ++ I L+ +L + + QA+ KE ++L+D ++ +
Sbjct: 8484 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 8529
Query: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
+W+ LE ++ + +C ++M +L +N+ N +P+ L +IL
Sbjct: 8530 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 8589
Query: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
K ++ H+ +L Q V SL + L EG+D E + N+ ++L
Sbjct: 8590 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 8645
Query: 2819 VLKSTQRSQQLEFKLEERSN 2838
+ + ++ ++LE L+ S+
Sbjct: 8646 LKEVSRHIKELEKLLDVSSS 8665
Score = 67.0 bits (162), Expect = 6e-10
Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)
Query: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 7065 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7111
Query: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7171
Query: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7227
Query: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 7228 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7283
Query: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Q C ++ K L A I + + +C + +
Sbjct: 7284 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
Query: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
Query: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 7404 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7457
Query: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 7458 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7513
Query: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 7514 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7573
Query: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 7574 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7633
Query: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693
Query: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 7694 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7753
Query: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 7754 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7813
Query: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 7814 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872
Query: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 7873 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7932
Query: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 7933 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7990
Query: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 7991 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 8050
Query: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 8051 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8110
Query: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 8111 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8170
Query: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
++++ P D ++ + + + + + RV+R L
Sbjct: 8171 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8230
Query: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
AL D R+A LS +P ++LS S Q + + ++ + + + H
Sbjct: 8231 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 8289
Query: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
+ L+ + A +D ++ D + ++ LS H ++ + + K L+ F+
Sbjct: 8290 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 8348
Query: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
+Q + I K PT P + K ++L +D + + L+E
Sbjct: 8349 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 8398
Query: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
SLP F + + Q + WE L + L + R+ + L+++Q F S L +
Sbjct: 8399 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8453
Query: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
L EE + LQ + L I IE+ ++ E + VD + ++
Sbjct: 8454 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 8505
Query: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
P F + ++++ D + L + WD++ +L ++EW +
Sbjct: 8506 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 8547
Query: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
+Q H+++ E+ +R K E+ + + + +++ +I+ L S++
Sbjct: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 8607
Query: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
+ LQ M +L E CL + H + L+ L + I E LL
Sbjct: 8608 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 8663
Query: 1772 SPSDSLEIFTKLEEI 1786
S L ++ +E+
Sbjct: 8664 SSQQDLSSWSSADEL 8678
Score = 66.6 bits (161), Expect = 8e-10
Identities = 690/3682 (18%), Positives = 1394/3682 (37%), Gaps = 539/3682 (14%)
Query: 706 VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
V L E +Q K G K + +T VA+D EK++ V+ W
Sbjct: 5160 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219
Query: 756 VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
V ++ +++ L A+ + EL+ E D ++++ Q+S +L
Sbjct: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5276
Query: 814 AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
+ +Q+ L+ + + D L+++ K++ + K ++ + + + Q S
Sbjct: 5277 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5334
Query: 874 PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
+ + KE L + T + L+ ++ L T ++I+ EE+ + L
Sbjct: 5335 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5393
Query: 931 HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
ELSL + ++ +D++ + ++ D I ++E+ ++L R+ + K L ++
Sbjct: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5453
Query: 988 CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
+ Q +VL EEL S+ L + + +++ L+ ++ L G
Sbjct: 5454 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504
Query: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
T ++ TI +ENR + A + N+ EKA T+ ++ AS LR
Sbjct: 5505 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5564
Query: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
+ ++++E K+ + + ++ E+ + + + ++ E + ++
Sbjct: 5565 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5621
Query: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
+L +LQ + E + + LE + P V R +LKE+ Q L +
Sbjct: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5678
Query: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
MESL+ ++ V LC S L + + + L A R+ + +Q + +Q
Sbjct: 5679 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5729
Query: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
CN MQ +++Y+ + M H Q E + +ED
Sbjct: 5730 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5763
Query: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
++ + +L A ++ +E +K + +I + K K L K M E
Sbjct: 5764 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
LD + H V + LL ++ E + S+IS
Sbjct: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5875
Query: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
+ P T +V L + + K H A S ++ G E +
Sbjct: 5876 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5934
Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
+ + WE K +++E LE ++YQ+ ++T ++ E + L S
Sbjct: 5935 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5992
Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA-----N 1621
+ + ++AE + + +E L + D+IN++ +L L ++ E P E+ A
Sbjct: 5993 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQLALQSTLT 6048
Query: 1622 IIVDRWLDI-----------NEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKME 1670
++ +R I EK D E + AL + + +D W ++
Sbjct: 6049 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL-QRYRCEADELDSWLLSTKATLD 6107
Query: 1671 LHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHV 1730
++ ++ +L + E ++V + L + E ++E K E
Sbjct: 6108 TALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL----SVHNENLLLEGKAHTKDEAE 6163
Query: 1731 QKCLTGESNCHALSGSTAELREDLDQAKTQIGMT----ESLLKALSPSDSLEIFTKLEEI 1786
Q L G+ L GS EL+ L + + T E L+ + S + L +
Sbjct: 6164 Q--LAGK--LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQA 6219
Query: 1787 QQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLND---- 1842
+ QQ+ S + + + L EL+E K SV+ ++ ++Q ++ D
Sbjct: 6220 RTTWTQQRQSSLQQQKE---LEQELAEQKSLLRSVAS--RGEEILIQHSAAETSGDAGEK 6274
Query: 1843 -----QCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
Q S+ + ++ +ES + S +QKL L + L E + + +
Sbjct: 6275 PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL--LQNVLEQEQEQVLYSRPNRL 6332
Query: 1898 LKHV---KKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRN 1954
L V K +P + S L G E++ S AK L+Q +L D
Sbjct: 6333 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSS-QSGGAKRQSIHLEQ--KLYDGVSA 6389
Query: 1955 LRKWLTNQEEK-WKGMEEPGEKTE--LFCQ-ALARKREQFESVAQLNNSLKEYGFTE--E 2008
WL + EE+ + E+TE LF Q LA+ ++ N +L F E +
Sbjct: 6390 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 6449
Query: 2009 EEIIMEAT--CLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
++E T CL+ R L +++ + K + +F + + + + K ++
Sbjct: 6450 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQ 6509
Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE--SSEAPLVQKTLTDISNQWD 2124
++ + P+ E+I+ I++ E DA I + ++ + E P +Q+ L+ + + +D
Sbjct: 6510 KLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE-LSKLQDMYD 6568
Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG-----FALQHGLQEKK 2179
+ + + S + L +Y ++ +DL L+E +++ AG + + +Q+
Sbjct: 6569 ELMMIIGSRRSGLNQNLTLKSQYERALQDL-ADLLETGQEKMAGDQKIIVSSKEEIQQLL 6627
Query: 2180 AQLKIYKKFLKKAQDLTSLL----------KELKSQGNYLLECTKNPSFSEEPWLEIKHL 2229
+ K Y + L+ LT L KE + + + + + + +E++++
Sbjct: 6628 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6687
Query: 2230 HESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKL 2289
E+ L + Q L R+ + + + + +N D+ +D+I + + L
Sbjct: 6688 LET-WSHLDEDQQELS---RQLEVVESSIPSVGLVEEN--------EDRLIDRITLYQHL 6735
Query: 2290 Q-KLQELENRL--SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRL 2346
+ L E + +L L DG I ++ + +G+ + + K K+L
Sbjct: 6736 KSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK----MSKELHR-- 6789
Query: 2347 ASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEIN 2406
L +ILK + + + + A ++ TQ+S V ++ E+
Sbjct: 6790 ----------LETILKHWTRYQSESADLIHWLQ-SAKDRLEFWTQQSVTV---PQELEMV 6835
Query: 2407 KDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLEL---DTMLRNEQLEEIEKLYT 2463
+D + + ++AQ S+K++ V NQ L L DT +L I+ +T
Sbjct: 6836 RDH-LNAFLEFSKEVDAQSSLKSS-----VLSTGNQLLRLKKVDTATLRSELSRIDSQWT 6889
Query: 2464 QLEAKKAAIK---------PLEQTECLNKTETGALVLHN------------IGYSAQH-- 2500
L A++ L +++ + ++ N IGY A H
Sbjct: 6890 DLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEY 6949
Query: 2501 -----------------LDNLLQALITL-KKNKESQYCVLRDFQEYLAAVESS---MKAL 2539
+D + Q+++ + ++ ES+ DF E L A+ S ++ L
Sbjct: 6950 LQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 7009
Query: 2540 LTDKESLKVGPLDSVT-YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES 2598
+T+K L G L+S + Y + ++ E ++ L + S D + LE
Sbjct: 7010 VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLED 7069
Query: 2599 QIKQLEHGWEQVEQQ----IQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLK 2654
IK E E++EQ IQ K ++ V +TL ++ T +L L++ LK
Sbjct: 7070 LIKAKEKEVEKIEQNGLALIQNK--KEDVSSIVMSTL-RELGQTWANLDHMVGQLKILLK 7126
Query: 2655 SPEERAGNQSMI--ALTTDLQATKHG---FSVLKGQAELQMKRIWGEKEKKNLEDGINNL 2709
S ++ + + + + L ++ F +L G E ++ NL++ ++L
Sbjct: 7127 SVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV------DNLQNLQDDL 7180
Query: 2710 KKQWETLEPLHLEAENQIKKC------DIRNKMKETILWAKNLLGE----LNPSIPLL-- 2757
+KQ +L+ +K+C + N +KE + NLL E L S LL
Sbjct: 7181 EKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL 7240
Query: 2758 -----------------PDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYE 2800
+D +++ K D V + ++ D + L T +
Sbjct: 7241 WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVK 7297
Query: 2801 GS--DLNNTLEDLRNQYQMLVLKSTQRSQ--------QLEFKL-EERSNFFAIIRKFQLM 2849
S L+ E L+ Q + Q Q LE L +++++ A + ++
Sbjct: 7298 DSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETF 7357
Query: 2850 VQESETLIIPRVET-AATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELN-V 2907
+ E L VE + + H L Q+ ++E+ G + + LN +
Sbjct: 7358 AKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL-KGQMLKFSSMAPDLDRLNEL 7416
Query: 2908 FERLFLED----QLKNLK-----IRTNRIQRFIQNTCNEVEHK--IKFCRQFHE-KTSAL 2955
RL L D +++NL I + +RF + ++H+ ++ C + E
Sbjct: 7417 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTE 7476
Query: 2956 QEEADSIQRN--ELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWD 3013
Q+ A I N LL Q ++ + E+++ + L +I ++L+ +V D N
Sbjct: 7477 QKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7536
Query: 3014 FSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVV 3069
+ L V + ++ ++ +I+Q + E K + L ++ + + +
Sbjct: 7537 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP 7596
Query: 3070 LKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEE 3129
L+ + + + ++ R + + L E K+L + DS E LQ +L AE
Sbjct: 7597 LQQARTLFDEVQFKEKVF-LRQQGSYILTVEAGKQLLLSA---DSGAE-AALQAEL-AEI 7650
Query: 3130 NDKLYKVLQNMVLELSPKEL-----DEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKH 3184
+K +M LE K+L D + C+ + SL L K +L Q L + E H
Sbjct: 7651 QEKWKSA--SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELH 7708
Query: 3185 IQNEKDNCEAFQEQV--W----AEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQM 3238
E+ C+ + V W ++ +K + ++ S VE R++E+L
Sbjct: 7709 A--EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7766
Query: 3239 QLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEA-------IIIPYRVDVGNPEE 3291
QL+ LR + + + E E +T +E+ I+I ++ +
Sbjct: 7767 QLS----LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDY 7822
Query: 3292 SLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE 3351
E+ + ++ +++ +Q + E+L S +++Y L ++ + + + A+
Sbjct: 7823 QEEIAIAQENKIQ-----LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 7877
Query: 3352 TEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKAL----- 3406
+ + L + K + T L+ +E+ L + + + E +L + + L
Sbjct: 7878 KKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 7937
Query: 3407 --------VSNL----------ISTKEELMKLRQILRLLRLRCTENDGICLLKI-----V 3443
V NL +T E ++Q R L R IC + + +
Sbjct: 7938 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWR---NICAMSMERRLKI 7994
Query: 3444 SALWEKWLSLLEAAKEWEMWCEELKQEWKFVS----------EEIEREAIILDNLQEELP 3493
W W L+ +E W + ++ F S EE+++ + E L
Sbjct: 7995 EETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLT 8054
Query: 3494 EIS-------KTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG 3546
++ + T+ L + + + + Q +T +L+R++ E
Sbjct: 8055 QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE--- 8111
Query: 3547 AVETVPAFQEITSMKERCNKLLQKVQKNKEL-VQTEIQERHSFTKEIIALKNFFQQTTTS 3605
E A I + L ++ E VQ +I++ +F +EI N +Q
Sbjct: 8112 --EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 8169
Query: 3606 FQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
+ + + P + EE L++ + + ++ + ++ + + E + +
Sbjct: 8170 GEQLIEKSEPLDAAIIEEELDELRR---YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 8226
Query: 3666 KALEDI--------DEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQ 3717
LED ++ ++ +L PS N+ L Q ++ +
Sbjct: 8227 LELEDSAALSDLHWHDRSADSLLSPQPS--------------SNLSLSLAQPLRSERSGR 8272
Query: 3718 EIQKKMWDELDLWHSKLNELDSEVQDIVEQD-PGQAQEWMDNLMIPFQQYQQVSQRAECR 3776
+ + D + L +L +++ + + P + +E D+ + +S
Sbjct: 8273 DTPASV-DSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSAL 8331
Query: 3777 TSQLNKATVKMEEYSDLLKSTEAWIE---------NTSH-----LLAN-PADYDSLRTLS 3821
SQ+ + +++ ++ TE I +TS+ LL + DS++ L
Sbjct: 8332 ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 8391
Query: 3822 HHASTVQMALEDSEQKHNLLHSI--------FMDLEDLSIIFETDELTQSIQELS---NQ 3870
H + +L H+ + + LS + Q Q+ + N
Sbjct: 8392 HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNS 8451
Query: 3871 VTALQQKIMESLPQIQR--MADDVVAIESEV---KSMEKRVSKIKTILLSKEIFDFSPE- 3924
+ A E L Q+QR ++ D+ IE ++ K ++K V K I+LS + SPE
Sbjct: 8452 IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL--CSPEF 8509
Query: 3925 --EHLKHGEVILENIRPMKKTIAEIVSYQVELR-LPQTGMKPLPVFQRTNQLLQDIKLLE 3981
K + + + M + S E R L Q + F + L + +LE
Sbjct: 8510 TQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGL--LLMLE 8567
Query: 3982 NVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER 4041
N+ + +NE++ I +N A+ +H +L Q++ E+
Sbjct: 8568 NIDRRKNEIV------------------PIDSNLDAEILQDHHK-----QLMQIKHELLE 8604
Query: 4042 MEKQILSLNQRKEDLLVDLKAT 4063
+ ++ SL LLV+ + T
Sbjct: 8605 SQLRVASLQDMSCQLLVNAEGT 8626
Score = 41.2 bits (95), Expect = 0.036
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 8421 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
Query: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 8481 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
Query: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
L++E L + + + E +LL EN D +VP
Sbjct: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
Query: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8644
Query: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
LL++ + I+E E L + +S Q
Sbjct: 8645 LLKEVSRHIKELEKLLDVSSSQQ 8667
Score = 39.3 bits (90), Expect = 0.14
Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)
Query: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
++ + KE++ + + ++L Q ++++L +H V+ M K QIEHL HR
Sbjct: 316 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 374
Query: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
+ L L A+ KQ + RL W + +K+ + AWL + E V +I++
Sbjct: 375 DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 431
Query: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
+++ E+ ++ + N K+ ++ + + + D+L + +R+
Sbjct: 432 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
Query: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
+ + K L+ + + L S L++W+ + S +++ +
Sbjct: 492 VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 542
Query: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
+ + EQ+ + + ++ + A + E +++ + +WRN+
Sbjct: 543 YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 599
Query: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
R +EE W ++ + + + WL+ AE+ N SE +AK++ F
Sbjct: 600 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 646
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
R + + Q +N L + LKQ + N RW L V +
Sbjct: 647 FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 705
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
++E+ ++ + TE +L+ S + ++ L +Q + + + +
Sbjct: 706 MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 764
Query: 6303 LIVFGEQLIQKSEP 6316
+I LI K P
Sbjct: 765 IITKTAHLITKESP 778
Score = 35.4 bits (80), Expect = 2.0
Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)
Query: 6572 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6631
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498
Query: 6632 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6690
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q F
Sbjct: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1558
Query: 6691 Q 6691
+
Sbjct: 1559 E 1559
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 1956 bits (5068), Expect = 0.0
Identities = 1204/3338 (36%), Positives = 1863/3338 (55%), Gaps = 120/3338 (3%)
Query: 3645 KYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEK 3704
K +E++ + E+++ + +A ++E NE+L+ + + K+ N
Sbjct: 27 KLTELHQQTIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSAS 84
Query: 3705 MLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ 3764
L+++ + E K++ EL+ KL L S E+ Q E +
Sbjct: 85 QLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------R 135
Query: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH 3822
+ +++ Q + R L A M+++ LK +A +E L +P LSH
Sbjct: 136 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195
Query: 3823 --HASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
H + +L+ Q L S ED + + L + L + + LQ ++
Sbjct: 196 RQHLLSEMESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQ 252
Query: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENI 3937
+Q E E+K +++ + + K + + +E + E + + I
Sbjct: 253 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKI 312
Query: 3938 RPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQ 3997
+ ++ IA + S L + L L + + L+ V+
Sbjct: 313 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMM 372
Query: 3998 TNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLL 4057
T + L + + + +S A + P + Q ++ Q
Sbjct: 373 TAGRCHTL--LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--A 428
Query: 4058 VDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSY 4111
L+ +H QE E P+ T++ G + + SE++ ++
Sbjct: 429 ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALER 488
Query: 4112 LAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKIS 4171
++ ++ S K + + K SP+ S + M E +A ++Q+ +I+
Sbjct: 489 QQKYQDSLQSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EIN 542
Query: 4172 TSDNSMAQILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVE 4228
+S+A+ L +S + + +L+ T E +T ++A + L ++E
Sbjct: 543 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLE 601
Query: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
+ R E + L + + EL+ WL ++ +E QL+ CQ ML EIE
Sbjct: 602 EQRQE--QALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQ 659
Query: 4289 KVAFLLETC---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTI 4345
KV L E ++ L T+ EAE L+ KL+ +K +L ++Q L +K Q
Sbjct: 660 KVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ 719
Query: 4346 LKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFN 4405
K+ S+ + P L T Q RQ QQQ+ LE + EQK ++ +
Sbjct: 720 EKEESDVDLTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASR 778
Query: 4406 AKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKL 4465
+++ Q+ + T+ ++ S E + S + Q KW+ LH E S+K KL
Sbjct: 779 GEEILIQHSAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL 836
Query: 4466 PLPQLVEPQ----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENM 4521
L + Q S +L V +Y PT ++ T+ L+ L Q + +Q
Sbjct: 837 LQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGG 895
Query: 4522 TEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYL 4580
+ I+L++KL++ S L VEE L + L E+ + E LA ++K++
Sbjct: 896 AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSE 955
Query: 4581 ALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQN 4640
+ K +A G+N +++ + L L + R +K L ++QN
Sbjct: 956 EMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQN 1015
Query: 4641 EIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLH 4700
++K L+ L +K + Q L + Q VAEQ++ L+ ++ + +L+ G++L
Sbjct: 1016 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 1075
Query: 4701 LPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAH 4760
+ +QE+ KL+D+ D + ++ +R + L+ +SQ + LQ + +L++ G+EK+A
Sbjct: 1076 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 1135
Query: 4761 GHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVK 4820
SK +Q ++ HK +FQ L + M+L + KI+ +Q F E + +
Sbjct: 1136 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 1195
Query: 4821 ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
+ +++ + G++L+ +L+ W DE+ L + LE++ S++PSV LVEE E+RL++RI+
Sbjct: 1196 AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL 1255
Query: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
YQ +K ++ +LYQ L++GK+L+ S+SC +LE Q+ +L E WLS K+ ELHRL+
Sbjct: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
+LKH Y +S L WL+S++ L +W +QS+ V Q+L+ +R ++N F EFSKEVD
Sbjct: 1316 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDA 1375
Query: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
+SSLK++V+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLP
Sbjct: 1376 QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 1435
Query: 5061 SRKAITEMISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
SR AI+E++SW++ +E+ DED++ + + LQK+K F+++++ KQ VDFVN
Sbjct: 1436 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 1495
Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
QS+LQ+S+ DVESKR ++T+FAE LG MN+ W + G++ KIQ LE LLES +E EN +
Sbjct: 1496 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555
Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ES 5238
Q L W E QE+RLK + SVQ L DCQD+E+ + K K +++++Q+ L L ++
Sbjct: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615
Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
+ S + EL Q +++ V QLK ++SVL +W + +D++N + Y
Sbjct: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARY 1675
Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEE 5357
+ + + SLE ++ QV+NLQ+LQD+ E E S +K + +L C P V E +
Sbjct: 1676 SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN 1735
Query: 5358 KCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMS 5417
+ + RW + + IA+QLQ +++LLQLW+ Y + + A+ ++QQE + +L + +
Sbjct: 1736 TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN 1795
Query: 5418 GNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-Q 5476
+ + + +QD +L + K++ + ++L Q ++S + SL Q
Sbjct: 1796 KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 1855
Query: 5477 RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KE 5529
LE+ L + + + ++ F LE+L+ I+ EE L D H + +E
Sbjct: 1856 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 1915
Query: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSEL 5589
+ +L ++ +PD++ LNE+ +LPL+D +K +QN+NR W ++ ER S+L
Sbjct: 1916 RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL 1975
Query: 5590 QGIGL-NEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIA 5648
Q L ++ FL CE W++ L + E+ L V+++ + LLEQQ+ +++ +AE+ Q I
Sbjct: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 2035
Query: 5649 DSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTS 5708
S + +LL+ ++++R EF + + L+++WQ ++ +QR+G +D +RQWQ +
Sbjct: 2036 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 2095
Query: 5709 VENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL 5768
E L ++L + S+L + G L Q R+L E++ KE F R++ + LT+EAG++L
Sbjct: 2096 AEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL 2155
Query: 5769 LLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQV 5828
LL+ D + ++ ++++Q+ WK +L E K+ ++ W++CEK I + +L+
Sbjct: 2156 LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 2215
Query: 5829 LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK 5888
K + LP+ HE+LH E+ KELE ++ SWT +L +L +K L+ ++ +D+ +L
Sbjct: 2216 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 2275
Query: 5889 EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI 5948
E++E L RQWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q DI I
Sbjct: 2276 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI 2335
Query: 5949 EEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFD 6008
EEMIEKL+KD EEI + ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D
Sbjct: 2336 EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLD 2395
Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQD 6068
+I +RVKKLKET +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+
Sbjct: 2396 LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE 2455
Query: 6069 LQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR 6128
LQRDIE+HS GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR
Sbjct: 2456 LQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR 2515
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHE 6188
+KIEETWRLWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE
Sbjct: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575
Query: 6189 RLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQRE 6248
LTQLELINKQYRRLARENRTD+A LKQMVHEGNQRWDNLQ+RVT++LRRL+HF QRE
Sbjct: 2576 CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 2635
Query: 6249 EFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGE 6308
EFE R+SILVWLTEMDLQLTN+EHFSE D K++QL FQQEI+LN NKI+Q+I GE
Sbjct: 2636 EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 2695
Query: 6309 QLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDME 6368
QLI+KSEPLDA +IE+EL+EL RYCQEVFGRV R+H++L P +DE + S+ E ++E
Sbjct: 2696 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELE 2754
Query: 6369 DPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGD 6424
D + W R S +PSS SL ERSG +TP SVDSIPLEWDH D
Sbjct: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 2814
Query: 6425 VGGSSSHEEDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDS 6482
+ D E AL D E ++ + YL+ + S S + + +
Sbjct: 2815 L------SRDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLGKA 2865
Query: 6483 PSCPEHHYKQMEG-DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQED 6541
+Q E R+ P P T YK G + L + + L ++E+
Sbjct: 2866 LDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEE 2922
Query: 6542 GGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKK 6592
L G Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I WL
Sbjct: 2923 ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGD 2982
Query: 6593 TEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPEST 6652
TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES
Sbjct: 2983 TEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR 3042
Query: 6653 ELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHV 6712
+LQ RL Q++ W+ ++ WRG L+ +LMQCQ FH++S LLL L + R+ +
Sbjct: 3043 DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVP 3102
Query: 6713 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 6772
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 3103 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 3162
Query: 6773 EKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT---------- 6815
+LK L ++VS + L+ + +Q S S DE+D SG P +
Sbjct: 3163 GNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKT 3222
Query: 6816 -------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLL 6868
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL
Sbjct: 3223 PRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLL 3282
Query: 6869 LLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 6906
+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 3283 IGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 3320
Score = 218 bits (554), Expect = 2e-55
Identities = 505/2767 (18%), Positives = 1073/2767 (38%), Gaps = 296/2767 (10%)
Query: 3736 ELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLK 3795
ELD+ VQ +EQ+ + + + +QQ ++AE R S+LN+A +EEY+++L+
Sbjct: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
Query: 3796 STEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIF 3855
WIE L ++S L Q LE+S++ + L ++ L+ L+ ++
Sbjct: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
Query: 3856 ETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLS 3915
T++++Q + EL + L+Q I L +Q A D+ E+E+K ++ + + + L S
Sbjct: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
Query: 3916 KEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQ 3975
E+ S +E L H + +L + +K + + Q LR+P+ + LP+ +L +
Sbjct: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE 241
Query: 3976 DIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL 4035
+ L++ +Q +++ + Q ++++E+++L+Q++ A +E P + +L
Sbjct: 242 EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE--GAHREIED-KPVATSNIQEL 298
Query: 4036 QGEIERME----------KQILSLNQRKEDLLVDLK-ATVLNLHQHLKQEQEGVERDRLP 4084
Q +I R E +QI SLN + + L + K AT+L ++ EG E
Sbjct: 299 QAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE----- 353
Query: 4085 AVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLW 4144
+G + ++ + + + EES + N + + P+ +S S +
Sbjct: 354 ---DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVA 410
Query: 4145 KHDKDMEEDRA--SSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTE 4202
D + +D A + S +Q KI S ++ + P L P+ T
Sbjct: 411 NTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEP-----------GLEPSATA 459
Query: 4203 EGTTPPIEADTLDS--SDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQA-NVAV 4259
+ +TL + S+ Q L +E+ + + + L + T++ +EL L ++
Sbjct: 460 KLGDLQRSWETLKNVISEKQRTLYEALER-QQKYQDSLQSISTKMEAIELKLSESPEPGR 518
Query: 4260 EPETLNADMQQVLEQQLVGCQAMLTEIEHKVA--FLLETCKDQGLGDNGATQHEAEALSL 4317
PE+ A+ Q ++++ L+ Q + E++ +A + E+C + + A Q L+
Sbjct: 519 SPESQMAEHQALMDEILM-LQDEINELQSSLAEELVSESC-EADPAEQLALQSTLTVLAE 576
Query: 4318 KLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQ--PVNLSELES--IVTER 4373
++ T++ + +L+EK ++ + E ++ALQ EL+S + T+
Sbjct: 577 RMSTIRMKASGKRQLLEEKLND--------QLEEQRQEQALQRYRCEADELDSWLLSTKA 628
Query: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSA-----SN 4428
+ ++ +E + M+ ++ + IE + + H+ + E A +
Sbjct: 629 TLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVAL-SELSVHNENLLLEGKAHTKDEAE 687
Query: 4429 QASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMY 4488
Q + + S+L Q DK + K E V P V +
Sbjct: 688 QLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK--------EESDVDLTATQSPGVQEW 739
Query: 4489 NFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVE 4548
+ +T TQ Q S+LQ Q+ L+++L E L S E
Sbjct: 740 ------LAQARTTWTQ-----QRQSSLQQQK--------ELEQELAEQKSLLRSVASRGE 780
Query: 4549 EMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFD 4608
E+L G + + L+ E L + +K M E+ +
Sbjct: 781 EILIQHSAAETSGDAGE-KPDVLSQE-----LGMEGEKSSAEDQMRMKWESLHQEFSTKQ 834
Query: 4609 N-LQVCLEHTQAAAV-CRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG 4665
LQ LE Q + R L +G+ Y + K L+ L Q+ E+S
Sbjct: 835 KLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL---DGLNQAFEEVSS 891
Query: 4666 QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE---------------VY 4710
QS + Q + + L D ERL + ALL E +
Sbjct: 892 QSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIK 951
Query: 4711 KLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKV 4770
++ + +D + + E L G + L+ + + + Q K ++
Sbjct: 952 EMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL----DSVVNQRCHQMKERL 1007
Query: 4771 ALQAQIENH-KVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQC 4829
+N KV F L + + IL L E AEQ+ ++ E+ ++
Sbjct: 1008 QQILNFQNDLKVLFTSLADNKYI-------ILQKLANVFEQPVAEQIEAIQQAEDGLKEF 1060
Query: 4830 GMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
+ L ++ ++ S+++ ++ + ++ L + ++ Q +R +
Sbjct: 1061 DAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120
Query: 4890 GKHARLYQTLNE---GKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHL 4946
A L +T E G Q + S E++ + K +E + L + + + L + +
Sbjct: 1121 DL-ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGL----ESHMILTETLFRKI 1175
Query: 4947 LSY--NRDSDQLTKWLESS--------------QHTLNYWK---EQSLNVSQDLDTIRSN 4987
+S+ +++ T+ + + ++ L W E +S+ L+ + S+
Sbjct: 1176 ISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESS 1235
Query: 4988 INNFFEFSKEVDE-----------KSSLKT------AVISIGNQLLHLKETDTATLRASL 5030
I + + D KSSL V+ G +L L + L + L
Sbjct: 1236 IPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSDLESQL 1293
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS--DEDSVHSP 5088
Q + W ++ +L + + ++I W+ + + + + SV P
Sbjct: 1294 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 1353
Query: 5089 SSASQVKHLLQKHKEFRMEMDYKQWIVDFV---NQSLLQLSTCDVESKRYERTEFAEHLG 5145
V+ L EF E+D + + V LL+L D + R E L
Sbjct: 1354 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSE-------LS 1406
Query: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVI-- 5203
++ QW + + + L QL S + I + +W+ E +QK E I
Sbjct: 1407 RIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLME---NVIQKDEDNIKN 1463
Query: 5204 -----SVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPL-------LEDTASRI 5251
++ + L + + + K +D + QS L + S V + +
Sbjct: 1464 SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAM 1523
Query: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK----PVV 5307
++ +Q ++T+ QL ++ +L+ W Y E N+ ++ W+ + + +
Sbjct: 1524 NKSWQILQGLVTEKIQL---LEGLLESWSEY-----ENNVQCLKTWFETQEKRLKQQHRI 1575
Query: 5308 LSLETLRCQVENLQSLQDEAESSEGSWEKL-QEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
+++ +++ Q L+D ++ E EK+ Q + ++ V+ I+ + + W
Sbjct: 1576 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTW 1635
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++ + +S+L W ++ A + + L EA++ ++G+ E +
Sbjct: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL--MEARYSLSRFRLLTGS--LEAVQ 1691
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRL-----PQPAESSTHMLLP------GPLHSL 5475
+ +++ LQ D++K + + + S+ ++L P E+ T+ L L +
Sbjct: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751
Query: 5476 QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFL 5535
K LL ++ Q + E ++ N D +
Sbjct: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 1811
Query: 5536 NHVLALTAQSPDIEHLNEV--SLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIG 5593
+ + L + L+E+ LK + A +Q+ ++ + ALE+ Q
Sbjct: 1812 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQS-DQLSLSQHLCALEQALCKQQTS 1870
Query: 5594 LN---------EKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
L K L E WI E+I + ++ L + E+ + K
Sbjct: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK--------G 1922
Query: 5645 QTIADSYVTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQW 5702
Q + S + L L+ + + I L W +R + + Q
Sbjct: 1923 QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH 1982
Query: 5703 QDFTTSVENLFRFLTDTSHLLSA-VKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALT 5761
Q F E FL T L+ + G + L Q R+ HEL E+ F R++ ++
Sbjct: 1983 QTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA--HELFQAEM-FSRQQILHSII 2039
Query: 5762 LEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKE 5821
++ G++LL + ++ +++ L + W+ + + + S + W + + ++
Sbjct: 2040 ID-GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098
Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE-QSLASWTQNLKELQTMKADLTRHVL 5880
L+ L + L + L + L E++ + Q + T++A +
Sbjct: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158
Query: 5881 VED--VMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938
+ L+ ++ + +W+ +R+ +K+++ L W + + L +
Sbjct: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKK 2218
Query: 5939 KVLQTADISIEEM-IEKLQ-KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKL 5996
K+ Q+ EE+ E+++ K+ + ++++ QL + D L + + +++++
Sbjct: 2219 KLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERV 2278
Query: 5997 NKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDD 6056
+ +W+ L + R +++ E + L WL ++ES++S+ D+ +
Sbjct: 2279 ELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIE 2336
Query: 6057 QEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRR 6116
+ I+K L++D ++ A + + ++E++ I+ ++ R
Sbjct: 2337 EMIEK-------LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR 2389
Query: 6117 WRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE- 6175
W+++ + R K++ET Q+ + S WL E A P ++Y S E
Sbjct: 2390 WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKP----IVYDSCNSEE 2445
Query: 6176 ----LKRFEAFQRQIHERLTQLELINKQYRRLARE---NRTDT-ASRLKQMVHEGNQRWD 6227
L + QR I + T + + L + TD ++Q ++RW
Sbjct: 2446 IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWR 2505
Query: 6228 NL-------QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD 6280
N+ + ++ R + F + FE +S +E + + A
Sbjct: 2506 NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIYTVAK 2560
Query: 6281 DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV 6340
+++++ FQ+++ +++ + +L +++ A ++ + E ++ + RV
Sbjct: 2561 EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 2620
Query: 6341 SRFHRRL 6347
+ RRL
Sbjct: 2621 TSILRRL 2627
Score = 120 bits (300), Expect = 6e-26
Identities = 657/3524 (18%), Positives = 1283/3524 (36%), Gaps = 568/3524 (16%)
Query: 3211 AIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVE 3270
A++K E+N + K+ + +L Q + R + LN A +L Y E + ++
Sbjct: 6 AVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 65
Query: 3271 SITSLEAIIIPYRVDVGNPEESL-EMPLRKQ---EELESTVAHIQDLTEKLGMISSPEAK 3326
I +A ++ + N L E + Q EE + + ++ +TEKL ++S
Sbjct: 66 WIE--KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCT 123
Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSM 3386
++ + EL + +++ K + L+N + K + L K++ L Q+
Sbjct: 124 EKMSQQVAELGRETEELRQMIKIR-------LQNLQDAAKDMKKFEAELKKLQAALEQAQ 176
Query: 3387 SSL--PLSYREAL-ERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIV 3443
++L P R +L E+L + L+S + S K ++ ++ LR+ + L
Sbjct: 177 ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAA 236
Query: 3444 SALWEK----------WLSLLEAA----KEWEMWCEELKQEWKFVSEEIEREAIILDNLQ 3489
L E+ ++++AA +++E + L+Q + EIE + + N+Q
Sbjct: 237 LRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ 296
Query: 3490 EELPEISKTKEAATT----EELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
E +IS+ +E A +E L+ C+ K +L + + + +
Sbjct: 297 ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 356
Query: 3546 GAVETVPAFQEITSMKE--RCNKLLQKVQK-------NKELVQTEIQERHSFTKEIIALK 3596
G + P+ M RC+ LL V + N E+ S A
Sbjct: 357 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416
Query: 3597 N----FFQQTTTS-FQNMAFQDHPEKSEQFE------ELQSILKKGKLTFENIMEKLRIK 3645
N ++Q + Q A + HP S E E + K G L + E L+
Sbjct: 417 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL--QRSWETLKNV 474
Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
SE + +E Q ++ + +L+ I K+ LK S S
Sbjct: 475 ISEKQRTLYEALERQ-QKYQDSLQSISTKMEAIELKLSES-------------------- 513
Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSE-----VQDIVEQDPGQAQEWMDNLM 3760
+ ++ E + + DE+ + ++NEL S V + E DP + L
Sbjct: 514 -PEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLT 572
Query: 3761 IPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTL 3820
+ ++ + +A K + E+ +D L+ E E AD L
Sbjct: 573 VLAERMSTIRMKAS------GKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDSWLL 624
Query: 3821 SHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
S A T+ AL ++ + + + MD +++ + E + S + N+ L+ K
Sbjct: 625 STKA-TLDTALSPPKEPMD-MEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGK--- 679
Query: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
D+ + +++ ++ + +++ L K++ + + +V L
Sbjct: 680 -----AHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDL------ 728
Query: 3941 KKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNE 4000
T + Q L +T Q+ LQ K LE EQ LL+ V +
Sbjct: 729 --TATQSPGVQEWLAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLLRSVASR--- 778
Query: 4001 WDEEIENLKQILNNYSAQFSLE-HMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD 4059
EEI ++ + +A+ S + PD + ++GE E Q + + E L +
Sbjct: 779 -GEEI-----LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ---MRMKWESLHQE 829
Query: 4060 LKATVLNLHQHLKQEQEGVERDR----LPAVTSEEGGVAERDASERKLNRRGSMSYLAAV 4115
L L+QEQE V R L V +G V +D S S L +
Sbjct: 830 FSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS-------AVTSLLDGL 882
Query: 4116 EEEVEESSVKSDNGDEKAEPSPQ------SWSSLWKHDKDMEEDRASSSSGTIVQEAYGK 4169
+ EE S +S ++ Q S +S W D E+R ++ + +E
Sbjct: 883 NQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD---VEERLFVATALLPEETETC 939
Query: 4170 ISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLD-SSDAQGGLEPRVE 4228
+ +IL D E E N + P D D D G L R+
Sbjct: 940 LFNQ-----EILAKDI--KEMSEEMDKNKNLFSQAF--PENGDNRDVIEDTLGCLLGRLS 990
Query: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
+ H K ++ ++ + V T AD + ++ Q+L E
Sbjct: 991 LLDSVVNQRCHQMKERLQQILNFQNDLKVLF---TSLADNKYIILQKLANV------FEQ 1041
Query: 4289 KVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMM----LQEKHSEDQHPT 4344
VA +E + ++G + +A + LK + K +E+ M LQ+ + E
Sbjct: 1042 PVAEQIEAIQQ---AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMII 1098
Query: 4345 ILKKSS-------EPEHQEALQPV----------NLSELESIVTERPQFSRQKDFQQQQV 4387
++S + +++ ALQ + + + IV+ + + + D ++
Sbjct: 1099 GSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF 1158
Query: 4388 LELKP---MEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSP 4444
L+ + + F K I F +K Q + ++SA + + + IL
Sbjct: 1159 QGLESHMILTETLFRKIISFAVQK----ETQFHTELMAQASAVLKRAHKRGVELEYILET 1214
Query: 4445 QGQNGDKWQYLHHELS-SKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTT 4503
+ Q L +L + +P LVE ++ +T+Y + E +
Sbjct: 1215 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR---LIDRITLYQHLKSSLNEYQPKLY 1271
Query: 4504 QLED------LRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLY 4557
Q+ D + S+L++Q N E +++ K +S+ L +E +L+ Y
Sbjct: 1272 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK-------MSKELHRLETILKHWTRY 1324
Query: 4558 REDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHT 4617
+ + S +H+ A + + + +++T P E L D+L LE +
Sbjct: 1325 QSE-SADLIHWLQSAKDRLEFWTQ---------QSVTVPQE----LEMVRDHLNAFLEFS 1370
Query: 4618 Q---AAAVCRSKSLKAGLDYNR-------SYQNEIKRL-----------------YHQL- 4649
+ A + +S L G R + ++E+ R+ HQL
Sbjct: 1371 KEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430
Query: 4650 ------------IKSKTSLQQSL---------NEISGQSVAEQLQKADAYTVEL------ 4682
+ S SL +++ N I +++ E LQK + +++
Sbjct: 1431 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT 1490
Query: 4683 -------------ENAESRVAKLRDEGERLH--------LPYALLQEVYKLEDVLDSMWG 4721
++ ES+ + D E+L L + +++ LE +L+S W
Sbjct: 1491 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLES-WS 1549
Query: 4722 MLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKV 4781
L + F T+ ++ + + +IG + LK + L+ I+ +
Sbjct: 1550 EYENNVQCLKTWFETQEKR------LKQQHRIGDQASVQNALKDCQD---LEDLIKAKEK 1600
Query: 4782 FFQKLVAD-MLLIQAYS---AKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
+K+ + + LIQ + I+ S L+ WA L+ Q + L+S+L
Sbjct: 1601 EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN-------LDHMVGQLKILLKSVL 1653
Query: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ 4897
+W + + L +L L+ + E + ++ Q ++ ++ + L +
Sbjct: 1654 DQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQK 1713
Query: 4898 TLNEGKQLVASVSCPELEGQIAKLEE---QWLSLNKKIDHELHRLQALLKHLLSYNRDSD 4954
+ QL+ P E L+E +W +L ++I +L +ALL+ Y S
Sbjct: 1714 FGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSK 1773
Query: 4955 QLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ 5014
Q ++ + N + + N D + + I + + K + + +G Q
Sbjct: 1774 QCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 1833
Query: 5015 LLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMN 5073
L + A+ +++ Q L L Q L ++ K++ + +W+
Sbjct: 1834 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 1893
Query: 5074 NVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESK 5133
E +D HS S S ++ +++ K ++ +D +N+ +L D E K
Sbjct: 1894 EAEEILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK 1952
Query: 5134 RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERL 5193
R + +NR W + + L+ L K + +L E++L
Sbjct: 1953 RMQ---------NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL 2003
Query: 5194 KT---------LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLL 5244
L++ + Q + Q I + + I + L LE G V
Sbjct: 2004 AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL---------LEQGQVDDR 2054
Query: 5245 EDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYC-MEHS 5303
++ ++ L + V+ + Q + + S +++W+ Y ++ +++ + Y M
Sbjct: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 2114
Query: 5304 KPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAE-IIEEKCQNT 5362
V + L+ R + +Q + +GS+ E +L S AE ++ +
Sbjct: 2115 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEI 2174
Query: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA 5422
++W + + +Q +K LL+ W+ ++ +L+ + K +S S +
Sbjct: 2175 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK------LSQSLPDHH 2228
Query: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQR----- 5477
E L KEL++ V + Q S + D L + +L + LQR
Sbjct: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEEL 2288
Query: 5478 ---AAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHE-----EENLDRLHQQEKE 5529
+ + + + NE+ + K+ L ++ + EE +++L + +E
Sbjct: 2289 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE 2348
Query: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQW---IRATATALERC 5586
+ + L E L + S + S++ K L +N +W + A +++
Sbjct: 2349 EIAIAQENKIQLQQMG---ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKL 2404
Query: 5587 SE-LQGIGLNEKFLYCCEKWIQLLE-KIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
E L + +K + W+ +E ++ + + D NS E+ + + L+ ++ +
Sbjct: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKH 2463
Query: 5645 QTIADSYVTQSLQLL---DTTEIENRPEFITEFSKLTD-RWQNAVQGVRQRKGDVDGLVR 5700
T S + LL D + + I + ++ D RW+N +R+ ++ R
Sbjct: 2464 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 2523
Query: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRS-LIHELKNKEIH----FQRRR 5755
WQ +FL D S +K ER + + + S +I+ + +E+ FQR+
Sbjct: 2524 LWQ----------KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV 2573
Query: 5756 TTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQC 5815
C LE K RR++ +++ D L +M+ + + WD
Sbjct: 2574 HECLTQLELINKQY------------RRLA--RENRTDSACSLKQMVHEGN---QRWDNL 2616
Query: 5816 EKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADL 5875
+K++ + RL+ Q E+ + S+ W L E+ ++
Sbjct: 2617 QKRVTSILRRLKHFIGQREE---------------FETARDSILVW---LTEMDLQLTNI 2658
Query: 5876 TRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQ 5935
H DV +Q++ ++ +++ +IE + EK++ L A +
Sbjct: 2659 -EHFSECDVQAKIKQLKAFQQE-------ISLNHNKIEQIIAQGEQLIEKSEPLDAAI-- 2708
Query: 5936 MENKVLQTADISIEEMIEKLQKDCME---EINLFSENKLQLKQMGDQLIKASNKSRAAEI 5992
IEE +++L++ C E + + + ++L D+ R E+
Sbjct: 2709 ------------IEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDE---HDLSDRELEL 2753
Query: 5993 DDKLNKINDRW-QHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVY 6051
+D + W D + S + + Q L S T + L Y
Sbjct: 2754 EDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 2813
Query: 6052 DVCDDQEIQKRLA---EQQDLQRDIE-----------QHSAGVESVFNICDVLLHDSDAC 6097
D+ D E A E ++ Q D + HSA +ES L DS
Sbjct: 2814 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGKALDDSRFQ 2872
Query: 6098 ANETE--CDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDW--LK 6153
+TE S T LD ++ + E I+ RL K ++ + L
Sbjct: 2873 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 2932
Query: 6154 SAE-RTAACPNSSEVLYTSA-------KEELKRFEAFQRQIH-------------ERLTQ 6192
S E +TA + E+L A K+ L++++ F ++ E+L +
Sbjct: 2933 STETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQR 2992
Query: 6193 LEL------INKQYRRL----------------------------ARENRTDTASRLKQM 6218
LEL I Q ++L ++E+R D RL QM
Sbjct: 2993 LELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDRLSQM 3051
Query: 6219 VHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHF-SES 6277
N RWD + + L+ Q + F +L+ L +D + + S
Sbjct: 3052 ----NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNL 3107
Query: 6278 DAD---DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQ 6334
DA+ D +QL + E+ + ++ L QL+ +E D + ++++ + +
Sbjct: 3108 DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 3167
Query: 6335 EVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPSSPQSLC 6394
+ VSR + L +++ S + E R +P+ C
Sbjct: 3168 LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKC 3227
Query: 6395 HLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGP 6438
L PG S H+ G S E GP
Sbjct: 3228 SLSQPGPSVSS--------------PHSRSTKGGSDSSLSEPGP 3257
Score = 92.0 bits (227), Expect = 2e-17
Identities = 369/2091 (17%), Positives = 813/2091 (38%), Gaps = 317/2091 (15%)
Query: 1973 GEKTELFCQALARKREQFESVAQLNNSLKEYG--------FTEEEEIIMEATC------- 2017
G+ TEL Q + + + + Q + L+EY + E+ +++ T
Sbjct: 26 GKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85
Query: 2018 LMDRY---QTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLN--SSEG 2072
L ++Y QTLL + EI+ E + + + Q ++ +++ + + L + E
Sbjct: 86 LREQYILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEEL 140
Query: 2073 KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAST 2132
+ ++ R+Q +++ + +A ++ + E ++A L + +S
Sbjct: 141 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---------LKE 191
Query: 2133 YLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGL---QEKKAQLKIYKKFL 2189
LSH++ LL E E LK K +A Q L ++ A L + L
Sbjct: 192 QLSHRQHLLSEMES--------------LKPKVQAVQLCQSALRIPEDVVASLPLCHAAL 237
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD------SVQN 2243
+ ++ + L Q N + E+ ++ L E ++++D ++Q
Sbjct: 238 RLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE 297
Query: 2244 LDGHVREHDS-------YQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELE 2296
L + H+ YQ + LN+ + + + + VE + ++L+
Sbjct: 298 LQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMK-AKHATMLLTVTEVEGLAEGTEDLD 356
Query: 2297 NRLSLQDGTLKKILALAKS-----VKQNTSSVGQKIIKDDIKSLQ-CKQKD-LENRLASA 2349
L ++ + + T G++ +I S C+ + N AS
Sbjct: 357 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416
Query: 2350 KQEM--------ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEE 2401
Q++ E K ST +F PG E AT+ + + + ++ +
Sbjct: 417 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 476
Query: 2402 DWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNE------------LQNQPLELDTM 2449
+ + A+E Q SL + S K E K++E ++Q L + +
Sbjct: 477 EKQRTLYEALERQQKYQDSLQSI-STKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL 535
Query: 2450 LRNEQLEEIEK-LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQAL 2508
+ +++ E++ L +L ++ P EQ + A + I A LL+
Sbjct: 536 MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK 595
Query: 2509 ITLKKNKESQYCVLRDFQEYLAAVES---SMKALLTDKESLKVGPLDSVTYLDKIKKFIA 2565
+ + ++ Q L+ ++ ++S S KA L S P+D L + +
Sbjct: 596 LNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV 655
Query: 2566 SIEKEKDSLGNLKIKWENL----SNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY--- 2618
IE++ +L L + ENL H D + + L ++++L+ ++++ + K
Sbjct: 656 EIEQKVVALSELSVHNENLLLEGKAHTKD-EAEQLAGKLRRLKGSLLELQRALHDKQLNM 714
Query: 2619 ---SQQVVEYDEFTTLMNK-------VQDTEISLQQQQQHLQLRLKSPEERAGNQSM--- 2665
+Q+ E D T Q QQ+Q LQ + + +E A +S+
Sbjct: 715 QGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRS 774
Query: 2666 IALTTDLQATKHGFSVLKGQA----ELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
+A + +H + G A ++ + + E EK + ED ++ +WE+ LH
Sbjct: 775 VASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED---QMRMKWES---LHQ 828
Query: 2722 EAENQIKKC-DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQ 2780
E + K ++ + +E +L+++ L +PL D+ +Q +
Sbjct: 829 EFSTKQKLLQNVLEQEQEQVLYSRP--NRLLSGVPLYKGDVPTQ-------------DKS 873
Query: 2781 SVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
+V SL + + +++ G ++ + Y + ST +EER
Sbjct: 874 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD-----VEER---- 924
Query: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
+ L+ +E+ET + + E K+++E+ + + +
Sbjct: 925 -LFVATALLPEETETCLFNQ-----------------EILAKDIKEMSEEMDKNKNLFSQ 966
Query: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH------------KIKFCRQF 2948
+ E N R +ED L L R + + + C++++ K+ F
Sbjct: 967 AFPE-NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLA 1025
Query: 2949 HEKTSALQEEADSIQR---NELLLNQEVNKGVKE------EIYNLKDRLTAIKCCILQVL 2999
K LQ+ A+ ++ ++ Q+ G+KE E+ D+L + + ++
Sbjct: 1026 DNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS 1085
Query: 3000 KLKKVFDYIG--LNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE-HGKYQALLSKMR 3056
KL+ ++D + + S L+Q T + E+ L++ L+T +E+ G + ++S
Sbjct: 1086 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 1145
Query: 3057 AIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNE--NKTFDDS 3114
I + K E + L +I+S ++K E++ + + +
Sbjct: 1146 EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRG 1205
Query: 3115 FKEKEILQ----IKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV---LNQ 3167
+ + IL+ + + +E + +V+++ + + E +E D++ H+ LN+
Sbjct: 1206 VELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNE 1265
Query: 3168 IKSQLQQ------PLLINLEIKHIQNEKDNC-EAFQEQVWAEMCSIKAVTAIEKQREENS 3220
+ +L Q LLI++ ++++ + E + + + I K
Sbjct: 1266 YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325
Query: 3221 SEASDVETKLREFED-LQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAII 3279
SE++D+ L+ +D L+ S+ + L ++L + E ++ V++ +SL++ +
Sbjct: 1326 SESADLIHWLQSAKDRLEFWTQQSVTV-PQELEMVRDHLNAFLE-FSKEVDAQSSLKSSV 1383
Query: 3280 IP--------YRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQY 3331
+ +VD L + +L + + +Q+ +L M KL ++
Sbjct: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQM-----DKLPSRH 1438
Query: 3332 TLQELVSKNSAMKEAFKAQETEAE---------RYLENYK-------CYRKMEEDIYTNL 3375
+ E++S S M+ + E + YL+ YK C + + + ++
Sbjct: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498
Query: 3376 SKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND 3435
++ + +S S + E L + +S ++ L++ K +L++ LL +
Sbjct: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE-----GLLESWSEYEN 1553
Query: 3436 GICLLKIVSALWEKWL----------SLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
+ LK EK L S+ A K+ C++L+ K +E+E+
Sbjct: 1554 NVQCLKTWFETQEKRLKQQHRIGDQASVQNALKD----CQDLEDLIKAKEKEVEKIE--- 1606
Query: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
Q L I KE ++ +S L + L Q N++ L +LL+ + SS
Sbjct: 1607 ---QNGLALIQNKKEDVSSIVMSTLRE-LGQTWANLDHMVGQLKILLKSVLD----QWSS 1658
Query: 3546 GAVETVPAFQEITSMKERCNKLLQK---VQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
V AF +I S L + + + E VQ ++ + ++ + Q+
Sbjct: 1659 HKV----AFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 1714
Query: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKL--RIKYSEMYTIVPAEIESQ 3660
+ + + HP + E L + LK+ + + N++E++ +++ S+ + +
Sbjct: 1715 GSITNQLLKECHPPVT---ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 1771
Query: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
++C ++ +++ +NE+LK+ A + I + V +Q + ++ ++
Sbjct: 1772 SKQCASTVQQQEDR-TNELLKA----ATNKDIAD-----DEVATWIQDCNDLLKGLGTVK 1821
Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECR-TSQ 3779
++ +L ++D+ ++ D + Q+ ++A C+ +
Sbjct: 1822 DSLFFLHELGEQLKQQVDASAASAIQSD-----------QLSLSQHLCALEQALCKQQTS 1870
Query: 3780 LNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHN 3839
L + E ++ L++ EAWI +L + S ST+Q +E+ + +
Sbjct: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP-----SHSSDLSTIQERMEELKGQML 1925
Query: 3840 LLHSIFMDLEDLSIIFE----TDELTQSIQELSNQVTALQQKIMESLPQIQ 3886
S+ DL+ L+ + D+ + +Q L+ + + + E ++Q
Sbjct: 1926 KFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976
Score = 90.9 bits (224), Expect = 4e-17
Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)
Query: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 1106 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 1161
Query: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 1162 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 1218
Query: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 1219 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 1278
Query: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 1279 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 1333
Query: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 1334 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 1393
Query: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 1394 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 1453
Query: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
QK E +K + IH LQ G N +T + +S
Sbjct: 1454 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 1513
Query: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 1514 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 1559
Query: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 1560 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 1619
Query: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 1620 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 1678
Query: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 1679 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738
Query: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 1798
Query: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 1799 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 1855
Query: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 1856 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 1908
Query: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 1909 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 1968
Query: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 1969 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 2025
Query: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 2026 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 2082
Query: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 2083 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142
Query: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
+ + + L S LQ + I K + L + A L
Sbjct: 2143 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 2196
Query: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 2197 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 2252
Query: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 2253 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 2312
Query: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 2313 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 2367
Query: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 2368 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 2424
Query: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
L + E +E + I+ +C
Sbjct: 2425 LAHIE------------------------------------------SELAKPIVYDSCN 2442
Query: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 2502
Query: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
R + I + E +IE + L QK L D S W + + + S
Sbjct: 2503 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 2551
Query: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 2552 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 2594
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 2595 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641
Query: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 2642 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 2692
Query: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
+ + + + + II++++ L+ C + +R +K
Sbjct: 2693 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 2735
Query: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 2736 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 2792
Query: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
R + + PLE D L LE+ + P E E + +
Sbjct: 2793 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 2841
Query: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
+ +G S H L + L K + ++ + + + + L T +
Sbjct: 2842 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 2900
Query: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
+ + +D +K+ +++E++SL ++ H T E+Q + WE
Sbjct: 2901 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 2947
Query: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
++ Q K Q + ++ +F + +N + DTE L+Q Q+ LQ+
Sbjct: 2948 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
Query: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
+LK ++ ++ I L+ +L + + QA+ KE ++L+D ++ +
Sbjct: 3008 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 3053
Query: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
+W+ LE ++ + +C ++M +L +N+ N +P+ L +IL
Sbjct: 3054 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 3113
Query: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
K ++ H+ +L Q V SL + L EG+D E + N+ ++L
Sbjct: 3114 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 3169
Query: 2819 VLKSTQRSQQLEFKLEERSN 2838
+ + ++ ++LE L+ S+
Sbjct: 3170 LKEVSRHIKELEKLLDVSSS 3189
Score = 85.1 bits (209), Expect = 2e-15
Identities = 363/1901 (19%), Positives = 732/1901 (38%), Gaps = 302/1901 (15%)
Query: 852 ESQKELESYMMRAQQLLGQRESPGE-LISKHKEALIISNTKSLAKYLKAVEELKNNVTED 910
+ QKELE + + LL S GE ++ +H A + L +EL E
Sbjct: 756 QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLS--QELG---MEG 810
Query: 911 IKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEK----------GKLSDNILKLEKQI 960
K S E++ R KWESLH E S + L+ +E+ +L + + +
Sbjct: 811 EKSSAEDQMR---MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV 867
Query: 961 NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
+ K GL + E S+ G + + H+E ++L + + + + L
Sbjct: 868 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLE--QKLYDGVSATST------WLD 919
Query: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
D E+++ E T +K+ ++ ++ + S+A DN+
Sbjct: 920 DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR---- 975
Query: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLER------YDTYRDILEHHLQNNK 1134
+E T+ L + S+++ + + + ER + +L L +NK
Sbjct: 976 DVIEDTLGCLLGRL-------SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNK 1028
Query: 1135 FRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFE--IISLKLENHVNDIKKPFV 1192
+ I ++ + Q ++ I+ D KEF+ II LK +++P
Sbjct: 1029 YIILQKLANVFE------QPVAEQIEAIQQAEDG-LKEFDAGIIELKRRGDKLQVEQP-S 1080
Query: 1193 IKERDTLKERERELQMTLNTRMESLETALRLVLPVEK-----ASLLLCGSD--------- 1238
++E L++ EL M + +R L L L E+ A LL G +
Sbjct: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
Query: 1239 ----------LPLHKMAIQGF--HLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVL 1286
L HK QG H+I + +++ + I ++ K+ + L + VL
Sbjct: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKI--ISFAVQKETQFHTELMAQASAVL 1198
Query: 1287 KELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLS 1346
K H + + L+Y E +H + ++ + LE +S+ + L E D
Sbjct: 1199 KRAH------KRGVELEY--ILETWSHLDEDQQELSRQLEVVESSIPSVGL-VEENEDRL 1249
Query: 1347 ASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAF 1406
+ Q ++ + +++ + D K L ++ +S D E + E L
Sbjct: 1250 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRL-----LISISCSDLESQLNQLGECWLSNT 1304
Query: 1407 SIKLSETHGY-GVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVP---- 1461
+ E H + + +T ++ +L+ +Q + ++ + TVP
Sbjct: 1305 NKMSKELHRLETILKHWTRYQS-------ESADLIHWLQSAKDRLEFWTQQSVTVPQELE 1357
Query: 1462 AVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKA 1521
V+ + + K +D K + N L K T+ + W
Sbjct: 1358 MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQW----- 1412
Query: 1522 LVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGK--ENLKKRIAEIEI 1579
T+ L V E L Q Q K I + S ISL + + K +N+K I
Sbjct: 1413 --TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG---- 1466
Query: 1580 VKEEFNEHLEVVD--KINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDY 1637
+ +E+L+ KI+ CK L + + E+ ++KT D+
Sbjct: 1467 -YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK--------RSDKT-DF 1516
Query: 1638 YENLGRALALW--------DKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVH 1689
E LG W +K+ L+ +++ W+E L E +RLK++ ++
Sbjct: 1517 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 1576
Query: 1690 EQKTSEFS-RRVAEIQFLLQSSEIPLELQVMESS----ILNKMEHVQKCLTGESNCHALS 1744
+Q + + + + +++ L+++ E E++ +E + I NK E V +
Sbjct: 1577 DQASVQNALKDCQDLEDLIKAKE--KEVEKIEQNGLALIQNKKEDVSS---------IVM 1625
Query: 1745 GSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQI 1804
+ EL + +G + LLK++ S ++I +++ ++S+ ++
Sbjct: 1626 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSH-KVAFDKINSYLMEARYSL----SRF 1680
Query: 1805 GCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFES 1864
LT L ++ Q +++ + LQD K Q ++ + S LKEC
Sbjct: 1681 RLLTGSLEAVQVQVDNLQN--------LQDDLEK----QERSLQKFGSITNQLLKECHPP 1728
Query: 1865 -----SETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVG 1919
+ T K V + L + + + ++SK ++L+ +++ K + K+ S +
Sbjct: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSK-----ALLQLWQRY--KDYSKQCASTV-- 1779
Query: 1920 QEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
Q+ E E + A K++ D ++ D +L K L ++ + E GE+ +
Sbjct: 1780 QQQEDRTNELLKAATNKDIAD--DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ 1837
Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMD---RYQTLLRQLSEIE--- 2033
A A Q + + SL ++ E+ + + T L Y+T + L +E
Sbjct: 1838 VDASAASAIQSDQL-----SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 1892
Query: 2034 -EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPE 2092
E +++L +D S + + ++E+K ++ +S + + ++ E+ P
Sbjct: 1893 VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSS------MAPDLDRLNELGYRLPL 1946
Query: 2093 GDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
D I K + +++ W + S + LL+ + +L+ E
Sbjct: 1947 NDKEI----------------KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
Query: 2153 DLRLMLIELKKK--QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLL---KELKSQGN 2207
L++ ++K E QH L++++A + + Q L S++ + L QG
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG- 2049
Query: 2208 YLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDN 2267
+ F+ + L + + + ++++ Q +D +R+ Y+ L L
Sbjct: 2050 ---QVDDRDEFNLKLTL-LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE 2105
Query: 2268 FSKEFVS-FSDKPV---------DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVK 2317
S +S P+ D++ +EK+ Q+ L+++ G K++L A S
Sbjct: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG--KQLLLSADSGA 2163
Query: 2318 QNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI---LKSKRSTEKKGKFT 2374
+ I++ KS + ++ + +LA ++ E C I L+ R+ +KK +
Sbjct: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
LP ++ ++ + AV +D + + S ++ +S +S + +
Sbjct: 2224 LPDHHEELHAEQMRCKELENAVGSWTDD--LTQLSLLKDTLSAYISADDISIL-----NE 2276
Query: 2435 KVNELQNQPLEL--DTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLH 2492
+V LQ Q EL LR +Q+ E + K E E L + E+
Sbjct: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK-----ELCEWLTQMESKV---- 2327
Query: 2493 NIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLD 2552
+Q+ D L++ +I K +D+QE +A + + L E L +
Sbjct: 2328 -----SQNGDILIEEMIEKLK---------KDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
Query: 2553 SVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES--QIKQLEHG---- 2606
S + IE + LG + +W++L + + KKL E+ ++QL+
Sbjct: 2374 SKA---------SEIEYK---LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 2421
Query: 2607 --W-EQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQ 2644
W +E ++ K +E +N+ Q+ + +++
Sbjct: 2422 RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 2462
Score = 73.9 bits (180), Expect = 5e-12
Identities = 322/1774 (18%), Positives = 692/1774 (39%), Gaps = 283/1774 (15%)
Query: 1400 ENLLDAFSIKLSETHGYGVQEEFTEENKLLEACI--------FKNNELLK-NIQDVQSQI 1450
EN++ + + GY E+ ++ K + I F N +L+ + QDV+S+
Sbjct: 1451 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKR 1510
Query: 1451 S-------KIGLKDPTVPAVKHRKKSLIRL-DKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
S ++G + + ++ I+L + +L+ + E + ++Q L + + +E
Sbjct: 1511 SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQ----CLKTWFETQE 1566
Query: 1503 KTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLK----QYQNFKSILTTLIQ-KEESV 1557
K + QQ + +A V L+ C + +L+K + + + LIQ K+E V
Sbjct: 1567 KRLKQQHRI------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
Query: 1558 ISLQASYMGK-----ENLKKRIAEIEI----VKEEFNEHLEVVDKINQVCKNLQFYLNKM 1608
S+ S + + NL + +++I V ++++ H DKIN ++ L++
Sbjct: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
Query: 1609 KTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFN-LKNVIDEWTEKALQ 1667
+ + + VD ++ + E +L + ++ ++L + E L+
Sbjct: 1681 RLLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738
Query: 1668 KMEL--HQLTEEDRERLKEELQVHE--QKTSEFSRRVAEIQFLLQSSEIPLELQVMESSI 1723
++ + + L EE E+L+ + + Q+ ++S++ A + Q + EL +
Sbjct: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST--VQQQEDRTNELL---KAA 1793
Query: 1724 LNKMEHVQKCLTGESNCHALSGSTAELREDL-------DQAKTQIGMTESLLKALSPSDS 1776
NK + T +C+ L +++ L +Q K Q+ + + + SD
Sbjct: 1794 TNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA---SAIQSDQ 1850
Query: 1777 LEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHF 1836
L + L ++Q + +Q+ S+ Q G L E K E++ + +LQ
Sbjct: 1851 LSLSQHLCALEQALCKQQTSL-----QAGVLDYET--FAKSLEALEAWIVEAEEILQGQD 1903
Query: 1837 SKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDF-LTLEGRNSKIKQVD 1895
+D S I+ ++E S+ L +L++ L + +IK++
Sbjct: 1904 PSHSSD--------LSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQ 1955
Query: 1896 SVLKH--VKKHLPKAHVKELISWLVGQEFELEK----MESICQARAK---ELEDSLQQLL 1946
++ +H + +L S+L+ + LEK ME + Q K E+ + Q LL
Sbjct: 1956 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 2015
Query: 1947 RLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFT 2006
Q H ELF + +++ S+ L E G
Sbjct: 2016 EQQRAH------------------------ELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051
Query: 2007 EE-EEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLM 2065
++ +E ++ T L +++Q ++R+ + + Q + ++A + W+ E+ M
Sbjct: 2052 DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPM 2111
Query: 2066 VLNSSEGKMPLE--------ERIQKIKEIILLKPEGDARI-----ETIMKQAESSEAPLV 2112
S G +P+ + +Q KE + L+ +G + + ++ A+S +
Sbjct: 2112 ---SGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAAL 2167
Query: 2113 QKTLTDISNQWDNTLHLASTYLSHQEK----LLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
Q L +I +W + AS L Q+K LL + EK + D L KKK
Sbjct: 2168 QAELAEIQEKWKS----ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223
Query: 2169 FALQHG-LQEKKAQLKIYKKFLKK-AQDLT--SLLKELKS---QGNYLLECTKNPSFSEE 2221
H L ++ + K + + DLT SLLK+ S + + + +
Sbjct: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283
Query: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL----DNFSKEFVSFSD 2277
W E+ H QQ+ + + ++ +T + + + D +E +
Sbjct: 2284 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 2343
Query: 2278 KPVDQ---IAVEEKLQ---------------KLQELENRLSLQDGTLKKILAL----AKS 2315
K + IA E K+Q K E+E +L + + +L L K
Sbjct: 2344 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 2403
Query: 2316 VKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA-------KQEMECCLNSILKSKRSTE 2368
+K+ +V Q + ++ SL+ +E+ LA +E++ LN + +R E
Sbjct: 2404 LKETLVAVQQ--LDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 2461
Query: 2369 KKG----------KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQ 2418
K + L + AT +S Q+ A L+ W + M+M ++
Sbjct: 2462 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQ--ATRNLDRRWR----NICAMSMERR 2515
Query: 2419 LSLNAQ--------ESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKL--------- 2461
L + + ED K +E ++ EE++K
Sbjct: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575
Query: 2462 -YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
TQLE + L + N+T++ + + Q DNL + + ++ + +
Sbjct: 2576 CLTQLELINKQYRRLARE---NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 2632
Query: 2521 VLRDFQ---EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
+F+ + + + M LT+ E D + ++K F I + + +
Sbjct: 2633 QREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKAFQQEISLNHNKIEQI 2690
Query: 2578 KIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY---------------SQQV 2622
+ E L +D ++E ++ +L ++V ++++ + S +
Sbjct: 2691 IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 2750
Query: 2623 VEYDEFTTLMN-----KVQDTEISLQQQQQHLQLRLKSP--EERAGNQSMIALTTDLQAT 2675
+E ++ L + + D+ +S Q +L L L P ER+G + ++ +
Sbjct: 2751 LELEDSAALSDLHWHDRSADSLLS-PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEW 2809
Query: 2676 KHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKC----- 2730
H + L E M R ++++ +D L+ L H E+QI++
Sbjct: 2810 DHDYD-LSRDLESAMSRALPSEDEEGQDDKDFYLRGA-VGLSGDHSALESQIRQLGKALD 2867
Query: 2731 DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIR---KCKVTHDGILARQQSVESLAE 2787
D R ++++T +N++ P+ P L ++ +C + D + + +E +
Sbjct: 2868 DSRFQIQQT----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV----KRLEHKLK 2919
Query: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
E ++ +P ++ + +++++L ++ + +++ L++ F + +
Sbjct: 2920 EEEESLPGFVNLHSTETQTA--GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI------ 2901
+ ++E + EL T+E K+L+E+ + + +I
Sbjct: 2978 AWLGDTEEEL-----EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 3032
Query: 2902 YEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADS 2961
+ + + E L+D+L + R +R+ ++ ++ + C+ FHE + L ++
Sbjct: 3033 FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 3092
Query: 2962 IQR--NELL-----LNQEVNKGVKEEIYNLKDRL 2988
I R NE++ L+ E+ + +++ +K L
Sbjct: 3093 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 3126
Score = 72.8 bits (177), Expect = 1e-11
Identities = 505/2870 (17%), Positives = 1040/2870 (36%), Gaps = 420/2870 (14%)
Query: 1286 LKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDL 1345
L ELH + +N + K +N E+ + LE L + AK+ A
Sbjct: 28 LTELHQQTIRQAENRLSK-------LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80
Query: 1346 SASDT---QVAQENTLTVKNKE--GEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCE 1400
+++ Q TL ++KE E+ M +K ++L MS + AE G +T E
Sbjct: 81 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET--E 138
Query: 1401 NLLDAFSIKLSETHGYGVQ-EEFTEENKLLEACIFKNNELL-----------KNIQDVQS 1448
L I+L ++F E K L+A + + L + + Q
Sbjct: 139 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 198
Query: 1449 QISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYE--EEKRHLQEMANSLPHFKDGREKTVN 1506
+S++ P V AV+ + +L + V+ LQE A+ L H T
Sbjct: 199 LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH-------TAI 251
Query: 1507 QQC---QNTVVLWENTK------------------------ALVTECLEQCGRVLELLKQ 1539
QQC Q VV +E + + + E Q R EL ++
Sbjct: 252 QQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 311
Query: 1540 YQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE-----------HL 1588
+ ++ + +L K + +++++A + + + E+E + E + H
Sbjct: 312 IKGYQEQIASLNSKCK-MLTMKAKHA---TMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 367
Query: 1589 EVVDKINQVCKNLQFYLNKMKTFE-------EPPFEKEANIIVDRWLDINEKTEDYYENL 1641
VV C L + + E PP + + + + +N+ YY+ L
Sbjct: 368 SVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIA-YYQAL 426
Query: 1642 GRALALWD--KLFNLKNVIDEWTEKALQKMELHQLTEEDR--ERLKEELQVHEQKTSEFS 1697
D K+ + E+ E L+ +L + R E LK + ++ E
Sbjct: 427 SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEAL 486
Query: 1698 RRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757
R + Q LQS I +++ +E + E + + + AL L++++++
Sbjct: 487 ERQQKYQDSLQS--ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINEL 544
Query: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQ 1817
Q + E L+ +D E Q+ Q +L E + +
Sbjct: 545 --QSSLAEELVSESCEADPAE----------QLALQSTLTVLAERMSTIRMKASGKRQLL 592
Query: 1818 YESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQK 1877
E ++D ++ Q+ + + + W + K L + +E +L
Sbjct: 593 EEKLNDQLEEQR---QEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD 649
Query: 1878 LSDFLTLEGRNSKIKQVDSVLKHVKKHLP------KAHVKELISWLVGQ----------- 1920
+ L +I+Q L + H KAH K+ L G+
Sbjct: 650 CQNMLV------EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 703
Query: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPG-EKTELF 1979
+ L + Q A+E E+S L Q +++WL W + ++ +
Sbjct: 704 QRALHDKQLNMQGTAQEKEESDVDLTATQSP--GVQEWLAQARTTWTQQRQSSLQQQKEL 761
Query: 1980 CQALARKREQFESVAQLNNSL---------------------KEYGF-----TEEEEIIM 2013
Q LA ++ SVA + +E G + E+++ M
Sbjct: 762 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM 821
Query: 2014 EATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGK 2073
+ L + T + L + E++ ++Q + ++ + K + + S
Sbjct: 822 KWESLHQEFSTKQKLLQNVLEQE-----QEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 876
Query: 2074 MPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTY 2133
L+ Q +E+ G A+ ++I + + + T D + L +A+
Sbjct: 877 SLLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLD---DVEERLFVATAL 931
Query: 2134 LSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ 2193
L + + L ++ L +D++ M E+ K + E + + L
Sbjct: 932 LPEETETCLFNQEILA--KDIKEMSEEMDKNKNL---FSQAFPENGDNRDVIEDTLGCLL 986
Query: 2194 DLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDS 2253
SLL + +Q + ++ + + ++K L SL +Q L + +
Sbjct: 987 GRLSLLDSVVNQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVA 1044
Query: 2254 YQV-CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEE----KLQKLQELENRLSL------- 2301
Q+ + L F + + D++ VE+ +L KLQ++ + L +
Sbjct: 1045 EQIEAIQQAEDGLKEFDAGIIELKRRG-DKLQVEQPSMQELSKLQDMYDELMMIIGSRRS 1103
Query: 2302 ---QDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLN 2358
Q+ TLK A + GQ+ + D K + +++++ L K+ + +
Sbjct: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
Query: 2359 SILKSKRSTEKKGKFTLPGREK-------QATSDVQESTQESAAVEKLEEDWEINKDSAV 2411
++ ++ K F + + QA++ ++ + + +E + E W +
Sbjct: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
Query: 2412 EMAMSKQL---SLNAQESMKNTED------------ERKVNELQNQPLEL----DTMLRN 2452
E++ ++ S+ + ++ ED + +NE Q + ++ +L +
Sbjct: 1224 ELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS 1283
Query: 2453 EQLEEIEKLYTQL-----EAKKAAIKPLEQTECLNKTET-----GALVLHNIGYSAQHLD 2502
++E QL K L + E + K T A ++H + + L+
Sbjct: 1284 ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE 1343
Query: 2503 NLLQALITLKKNKESQYCVLRDFQEYLAAVE--SSMKA--LLTDKESLKVGPLDSVTYLD 2558
Q +T+ + E L F E+ V+ SS+K+ L T + L++ +D+ T
Sbjct: 1344 FWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRS 1403
Query: 2559 KIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY 2618
++ + + + D L N+ E L H MDK I ++ +E IQK
Sbjct: 1404 ELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458
Query: 2619 S--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALTT 2670
+ + Y + K + +I + +Q + L++ S + +
Sbjct: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518
Query: 2671 DLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI-K 2728
L A + +L+G +++ + G E E+ + LK +ET E L+ +++I
Sbjct: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIGD 1577
Query: 2729 KCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEE 2788
+ ++N +K+ C+ D I A+++ VE + +
Sbjct: 1578 QASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQN 1608
Query: 2789 VKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQL 2848
+ + S + +TL +L + L Q L+ L++ S+ K
Sbjct: 1609 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 1668
Query: 2849 MVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE---- 2897
+ E+ +L R+ T + EA L++ LE ++ LQ+ S + L+E
Sbjct: 1669 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 1728
Query: 2898 ----LTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHE 2950
LTN +E+N+ LE+ QL++ K QR+ + K C
Sbjct: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYS--------KQC----- 1775
Query: 2951 KTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKVF 3005
S +Q++ D R LL NK + ++ I + D L + + L ++
Sbjct: 1776 -ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 1831
Query: 3006 DYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDLQ 3061
+ + D S +Q+ + L + KQ + + Y+ + A++
Sbjct: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 1891
Query: 3062 IKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI------IKKLNENKTFDDSF 3115
I + E+ L+ D S S + + +R+E+ K + + +LNE +
Sbjct: 1892 IVEAEEI-LQGQDPSHSS---DLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPL 1946
Query: 3116 KEKEILQIK-------LNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQI 3168
+KEI +++ L + + + + LQ+ +L+ + +K ET + L Q
Sbjct: 1947 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQ-------HQTFLEKCETWMEFLVQT 1999
Query: 3169 KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVET 3228
+ +L + N + H+ ++ E FQ ++++ + ++ I+ QR + D +
Sbjct: 2000 EQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSII-IDGQRLLEQGQVDDRDE 2056
Query: 3229 ---KLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVD 3285
KL + + R +++ RY+E + + + + + +
Sbjct: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116
Query: 3286 VGNPEESL-----EMPLRKQEELESTVAHIQDLTEKLGMISSPE--AKLQLQYTLQELVS 3338
V P + E+ +++ L ++I + ++ S + A+ LQ L E+
Sbjct: 2117 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 2176
Query: 3339 KNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALE 3398
K K A E + ++ K + K E+ I +L K+ T + SLP + E
Sbjct: 2177 K---WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233
Query: 3399 RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAK 3458
+ K L + + S ++L +L + L + +D L + V L +W L
Sbjct: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
Query: 3459 EWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYG 3518
E EW SE+ + + + L + ++S+ + E + +L Y
Sbjct: 2294 LRRQQIGERLNEWAVFSEKNKE---LCEWLTQMESKVSQNGDILIEEMIEKLKK---DYQ 2347
Query: 3519 ENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELV 3578
E + Q L Q + S A E ++ + +R LL + + +
Sbjct: 2348 EEIAIAQENKIQLQQMGERLAKASHESKASEIE---YKLGKVNDRWQHLLDLIAARVKKL 2404
Query: 3579 QTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
+ + K + +L+ + + D S EE+Q KL +
Sbjct: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD----SCNSEEIQR-----KLNEQQE 2455
Query: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNG 3698
+++ K+S + S + C L D D ++ S +++ ++
Sbjct: 2456 LQRDIEKHS-------TGVASVLNLCEVLLHDCDACATDAECDS-----IQQATRNLDRR 2503
Query: 3699 LHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----------------SEVQ 3742
N+ M ++ IE+ + +K D+ + L + E
Sbjct: 2504 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 2563
Query: 3743 DIVEQDPGQAQEWMDNLMIPFQQYQQVSQ--RAECRTSQLNKATVKMEEYSDLLKSTEAW 3800
E Q E + L + +QY+++++ R + S + + +L K +
Sbjct: 2564 KKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 2623
Query: 3801 IENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDEL 3860
+ H + ++++ R S + E Q N+ H + + + +L
Sbjct: 2624 LRRLKHFIGQREEFETARD-----SILVWLTEMDLQLTNIEH-----FSECDVQAKIKQL 2673
Query: 3861 TQSIQELSNQVTALQQKIMESLPQIQRMAD-DVVAIESEVKSMEKRVSKI 3909
QE+S ++Q I + I++ D IE E+ + + ++
Sbjct: 2674 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV 2723
Score = 67.0 bits (162), Expect = 6e-10
Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)
Query: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 1589 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 1635
Query: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 1695
Query: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 1696 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 1751
Query: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 1807
Query: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Q C ++ K L A I + + +C + +
Sbjct: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867
Query: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927
Query: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 1928 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 1981
Query: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 1982 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 2037
Query: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 2038 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 2097
Query: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 2098 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 2157
Query: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 2158 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 2217
Query: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 2218 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 2277
Query: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 2278 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 2337
Query: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 2338 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 2396
Query: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 2397 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 2456
Query: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 2457 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 2514
Query: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574
Query: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 2575 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 2634
Query: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 2635 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 2694
Query: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
++++ P D ++ + + + + + RV+R L
Sbjct: 2695 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 2754
Query: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
AL D R+A LS +P ++LS S Q + + ++ + + + H
Sbjct: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 2813
Query: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
+ L+ + A +D ++ D + ++ LS H ++ + + K L+ F+
Sbjct: 2814 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 2872
Query: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
+Q + I K PT P + K ++L +D + + L+E
Sbjct: 2873 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 2922
Query: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
SLP F + + Q + WE L + L + R+ + L+++Q F S L +
Sbjct: 2923 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
Query: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
L EE + LQ + L I IE+ ++ E + VD + ++
Sbjct: 2978 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 3029
Query: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
P F + ++++ D + L + WD++ +L ++EW +
Sbjct: 3030 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 3071
Query: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
+Q H+++ E+ +R K E+ + + + +++ +I+ L S++
Sbjct: 3072 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 3131
Query: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
+ LQ M +L E CL + H + L+ L + I E LL
Sbjct: 3132 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 3187
Query: 1772 SPSDSLEIFTKLEEI 1786
S L ++ +E+
Sbjct: 3188 SSQQDLSSWSSADEL 3202
Score = 41.2 bits (95), Expect = 0.036
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 2945 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 3004
Query: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 3005 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 3060
Query: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
L++E L + + + E +LL EN D +VP
Sbjct: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120
Query: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 3168
Query: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
LL++ + I+E E L + +S Q
Sbjct: 3169 LLKEVSRHIKELEKLLDVSSSQQ 3191
>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform 4
[Homo sapiens]
Length = 556
Score = 1077 bits (2785), Expect = 0.0
Identities = 541/556 (97%), Positives = 541/556 (97%), Gaps = 15/556 (2%)
Query: 6367 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 6426
MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG
Sbjct: 1 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 60
Query: 6427 GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 6486
GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP
Sbjct: 61 GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 120
Query: 6487 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 6546
EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG
Sbjct: 121 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 180
Query: 6547 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 6606
ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP
Sbjct: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 240
Query: 6607 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 6666
SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE
Sbjct: 241 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 300
Query: 6667 AAQGAVDSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHV 6712
AAQGAVDSWRGGLRQSLMQCQ DFHQLSQNLLLWLASAKNRRQKAHV
Sbjct: 301 AAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHV 360
Query: 6713 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 6772
TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI
Sbjct: 361 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 420
Query: 6773 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTE 6831
EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTE
Sbjct: 421 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 480
Query: 6832 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 6891
GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA
Sbjct: 481 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 540
Query: 6892 RSFYPMLRYTNGPPPT 6907
RSFYPMLRYTNGPPPT
Sbjct: 541 RSFYPMLRYTNGPPPT 556
Score = 40.8 bits (94), Expect = 0.047
Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)
Query: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
A I ++ + DRW+ + K+K+ +QQL+ ++S + TWL + E+EL
Sbjct: 179 AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 235
Query: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
+ D QEI+ R+ Q++ + + + A V SV L + E +
Sbjct: 236 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 295
Query: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
+ + + WR S+ + + R F D+ + WL SA+
Sbjct: 296 SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 355
Query: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
P + + EL + E +++ ER Q++++ + L + +
Sbjct: 356 QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 412
Query: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
++ VH ++ L+ +V+ L L+ N
Sbjct: 413 AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443
Score = 35.0 bits (79), Expect = 2.6
Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)
Query: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
ELH + ++L N D +T WL+ ++ L K D+ I + E
Sbjct: 199 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 256
Query: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
K D +L +V + L + ++ L++ L Q W
Sbjct: 257 LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 299
>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform 3
[Homo sapiens]
Length = 982
Score = 965 bits (2495), Expect = 0.0
Identities = 526/985 (53%), Positives = 668/985 (67%), Gaps = 58/985 (5%)
Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
MG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET +QQLDKNMS+LR
Sbjct: 1 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
TWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD D
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
ACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRL 6215
ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A L
Sbjct: 181 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
Query: 6216 KQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFS 6275
KQMVHEGNQRWDNLQ+RVT++LRRL+HF QREEFE R+SILVWLTEMDLQLTN+EHFS
Sbjct: 241 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
Query: 6276 ESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
E D K++QL FQQEI+LN NKI+Q+I GEQLI+KSEPLDA +IE+EL+EL RYCQE
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
Query: 6336 VFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQ 6391
VFGRV R+H++L P +DE + S+ E ++ED + W R S +PSS
Sbjct: 361 VFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
Query: 6392 SLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG-------GSSSHEEDEEG----PYY 6440
SL ERSG +TP SVDSIPLEWDH D+ + EDEEG +Y
Sbjct: 420 SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479
Query: 6441 ----SALSDVEIPENPEAYLKMTTKTLKASSG-KSISDGHSWHVPDSPSCPEHHYKQMEG 6495
LSDV IPE+PEAY+K+T +K +SG S + + + +Q E
Sbjct: 480 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 539
Query: 6496 -DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE----- 6549
R+ P P T YK G + L + + L ++E+ L G
Sbjct: 540 IIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 596
Query: 6550 -QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP 6605
Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I WL TE ELE L+ +
Sbjct: 597 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
Query: 6606 PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 6665
+DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W
Sbjct: 657 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
Query: 6666 EAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 6725
+ ++ WRG L+ +LMQCQ FH++S LLL L + R+ + D D L +
Sbjct: 717 DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
Query: 6726 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS- 6784
++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI +LK L ++VS
Sbjct: 777 HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
Query: 6785 -----QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT-----------------SVPAPR 6821
+ L+ + +Q S S DE+D SG P + S P P
Sbjct: 837 HIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPS 896
Query: 6822 AKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEED 6881
R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+ LACL+P SEED
Sbjct: 897 VSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEED 956
Query: 6882 YSCTQANNFARSFYPMLRYTNGPPP 6906
YSC +NNFARSF+PMLRYTNGPPP
Sbjct: 957 YSCALSNNFARSFHPMLRYTNGPPP 981
Score = 80.5 bits (197), Expect = 5e-14
Identities = 66/361 (18%), Positives = 157/361 (43%), Gaps = 23/361 (6%)
Query: 5765 GEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKS 5824
GE+L + + ++ ++ D W+ + +A +K+ + T+ Q +K + L++
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 5825 RLQVLKAQSEDPL-------PELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR 5877
L ++++ P+ E+ L+ ++EL +++E+ L + + D
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 5878 HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME 5937
+ +++ +L R+W ++C R+ +IE+ W F + WL E
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
Query: 5938 NKVLQTADISIEEMIEKLQKDCMEEINLFS----ENKLQLKQMGDQLIKASNKSR---AA 5990
A S +I + K+ +++ F E QL+ + Q + + ++R A
Sbjct: 182 R---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
+ +++ N RW +L + S +++LK ++ + ++ WL ++ +L+
Sbjct: 239 SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
Query: 6051 YDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDS---DACANETECDSIQ 6107
+ CD +Q ++ + + Q++I + +E + + L+ S DA E E D ++
Sbjct: 299 FSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
Query: 6108 Q 6108
+
Sbjct: 356 R 356
Score = 61.6 bits (148), Expect = 3e-08
Identities = 146/799 (18%), Positives = 302/799 (37%), Gaps = 132/799 (16%)
Query: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASY--MGKENLKKR 1573
W++ L+ +++ L ++Q S L T + ES ++ Y E ++++
Sbjct: 28 WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRK 87
Query: 1574 IAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR-WLDINE 1632
+ E + ++ + +H V + +C+ L + T E ++A +DR W +I
Sbjct: 88 LNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 147
Query: 1633 KTEDYYENLGRALALWDKLFNLKNVIDEWTEKA--------------------LQKMELH 1672
+ + + LW K + + ++W + + L+K E
Sbjct: 148 MSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAF 207
Query: 1673 Q-------------------LTEEDRE----RLKEELQVHEQKTSEFSRRVAEI------ 1703
Q L E+R LK+ + Q+ +RV I
Sbjct: 208 QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKH 267
Query: 1704 ------QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757
+F I + L M+ + N +EH +C ++ L E+ + ++
Sbjct: 268 FIGQREEFETARDSILVWLTEMDLQLTN-IEHFSECDV-QAKIKQLKAFQQEISLNHNKI 325
Query: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ-----QKHSMILLENQIGCLTPELS 1812
+ I E L++ P D+ I +L+E+++ + +++ L+ + +LS
Sbjct: 326 EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385
Query: 1813 ELKKQYE---SVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSET-- 1867
+ + + E ++SDL +S LL+ Q SN+ ++L + S +
Sbjct: 386 DRELELEDSAALSDLHWHDRSA-----DSLLSPQPS------SNLSLSLAQPLRSERSGR 434
Query: 1868 -------------------KKSVEQKLQKLSDFLTLEGRNSK---IKQVDSVLKHVKKHL 1905
+ +E + + EG++ K ++ + +
Sbjct: 435 DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 494
Query: 1906 PKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEK 1965
P+A+VK + + + +ES + K L+DS Q+ + ++ R+ +
Sbjct: 495 PEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
Query: 1966 WKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEY-----GFTEEEEIIMEATCLMD 2020
+KG + + L +SV +L + LKE GF + ++D
Sbjct: 555 YKG----------YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID 604
Query: 2021 RYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI---KEIKESLMVLNSSEGKMPLE 2077
R++ L Q E K + Q FN + + W+ +E E L L S +E
Sbjct: 605 RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664
Query: 2078 ERIQKIKEIILLKPEGDARIETI------MKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
+I+K+KE+ A I +I QA+S E+ +Q L+ ++ +WD L
Sbjct: 665 LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLE 724
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-----LQEKKAQLKIYK 2186
+ + L++ + + + L LML + +++ + LQ+ QL K
Sbjct: 725 EWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIK 784
Query: 2187 KFLKKAQDLTSLLKELKSQ 2205
L ++Q + L+++ Q
Sbjct: 785 HELLESQLRVASLQDMSCQ 803
Score = 55.8 bits (133), Expect = 1e-06
Identities = 128/669 (19%), Positives = 264/669 (39%), Gaps = 77/669 (11%)
Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE-TEERLVERISFYQQIKRNIGG 4890
KL+ L ++ D+N +SL L + S L + + E + +++ Q+++R+I
Sbjct: 41 KLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 100
Query: 4891 KHARLYQTLNEGKQLV-------ASVSCPELEGQIAKLEEQW-----LSLNKKIDHELHR 4938
+ LN + L+ C ++ L+ +W +S+ +++ E
Sbjct: 101 HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE-ET 159
Query: 4939 LQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEV 4998
+ K L Y+R D WL+SS+ T + + + + + F F ++V
Sbjct: 160 WRLWQKFLDDYSRFED----WLKSSERTAAFPSSSGVIYT----VAKEELKKFEAFQRQV 211
Query: 4999 DEKSSLKTAVISIGNQLLHLKETDTA-TLRASLAQFEQKWTMLITQLPDIQEKLHQLQME 5057
E + + +L TD+A +L+ + + Q+W L ++ I +L +
Sbjct: 212 HECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQ 271
Query: 5058 KLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF 5117
+ A ++ W+ ++ Q ++ + +++K L K F+ E+ +
Sbjct: 272 REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL----KAFQQEISLNH---NK 324
Query: 5118 VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE--- 5174
+ Q + Q +S+ + E L E+ R V G + R + L +L E
Sbjct: 325 IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 384
Query: 5175 SENKIQILN-------NWLEAQEERLKTLQKPESVISV---QKLLLDCQDIENQLAIKSK 5224
S+ ++++ + +W + + L + Q P S +S+ Q L + + ++ S
Sbjct: 385 SDRELELEDSAALSDLHWHDRSADSLLSPQ-PSSNLSLSLAQPLRSERSGRDTPASVDSI 443
Query: 5225 ALD-----ELKQSYLTLESGAVPLLEDTASRIDELFQKRSSV----------------LT 5263
L+ +L + + S A+P ED + D+ F R +V LT
Sbjct: 444 PLEWDHDYDLSRDLESAMSRALP-SEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502
Query: 5264 QVNQLKTSMQSVLQEWKI--YDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQ 5321
+ TS E +I + D+ + + P L+T +
Sbjct: 503 ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT---SYKGYM 559
Query: 5322 SLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEI--IEEKCQNTHKRWTQVN-QAIADQLQ 5378
L E SS S ++L+ + + + P + E + RW + QA++ +L+
Sbjct: 560 KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
Query: 5379 KAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHD 5438
Q+ LQ W+ +++ A L E + +QL + +S + + + ++ +KELQ
Sbjct: 620 MKQN-LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD--IQTIELQIKKLKELQKA 676
Query: 5439 VQKTKEAFL 5447
V K L
Sbjct: 677 VDHRKAIIL 685
Score = 55.8 bits (133), Expect = 1e-06
Identities = 56/290 (19%), Positives = 127/290 (43%), Gaps = 9/290 (3%)
Query: 4901 EGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWL 4960
E + L V+ E Q A + ++W L + + R++ L+ +N D + + WL
Sbjct: 582 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641
Query: 4961 ESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
++ L + Q L +S D+ TI I E K VD + ++ ++ +
Sbjct: 642 GDTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS 699
Query: 5021 TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080
++ L+ L+Q +W + + L + + L M+ + ++ + N++ + +
Sbjct: 700 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
Query: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEF 5140
+ + S A +LQ H + M++ + + + + + LQ +C + E T+
Sbjct: 760 EIVPIDSNLDA----EILQDHHKQLMQIKH-ELLESQLRVASLQDMSCQL-LVNAEGTDC 813
Query: 5141 AEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
E +++ +R+ +L +H+++ LE + + + Q L++W A E
Sbjct: 814 LEAKEKVHVIGNRLKLLLKEVSRHIKE-LEKLLDVSSSQQDLSSWSSADE 862
Score = 53.1 bits (126), Expect = 9e-06
Identities = 68/357 (19%), Positives = 146/357 (40%), Gaps = 16/357 (4%)
Query: 5673 EFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERF 5732
+ K+ DRWQ+ + + R + + Q ++ +L +L L+ +
Sbjct: 20 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
Query: 5733 SLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE----SVGRRISQLQ 5788
+ + + ++E + + ++ T A L E LL D + S+ + L
Sbjct: 80 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
Query: 5789 DSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP-LPELHEDLHN- 5846
W+++ A +++ ETW +K + + LK+ P ++
Sbjct: 140 RRWRNI---CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
Query: 5847 EKELIKELEQSLASWTQNLKELQTMKAD---LTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
KE +K+ E + L +L+ + L R + LK+ + +++W++L
Sbjct: 197 AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 256
Query: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCM 5960
RV + ++ + F + WL +M+ + ++ ++ I++L K
Sbjct: 257 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL-KAFQ 315
Query: 5961 EEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
+EI+L Q+ G+QLI+ S AA I+++L+++ Q +F + KKL
Sbjct: 316 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372
Score = 46.2 bits (108), Expect = 0.001
Identities = 78/381 (20%), Positives = 156/381 (40%), Gaps = 35/381 (9%)
Query: 5816 EKKIKEL-----KSRLQVLKAQ----SEDPL-PELHEDLHNEKELIKELEQSLASWTQNL 5865
E +I++L SR Q+ + + S+ P PEL +L+ E S+ S +
Sbjct: 517 ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 576
Query: 5866 KELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
+L+ + L V + + Q + +WE L + ++ ++ L W FN
Sbjct: 577 HKLKEEEESLPGFVNLHST---ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 633
Query: 5926 NKELCAWLVQMENKV--LQTADISIEEMIEKLQKDCMEEINLFSENK----LQLKQMGDQ 5979
+ AWL E ++ LQ ++S + +LQ ++E+ +++ L + +
Sbjct: 634 LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 693
Query: 5980 LIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA 6039
+A +K + ++ D+L+++N RW + ++ L++ Q + L L
Sbjct: 694 FTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 752
Query: 6040 RIESELSKPVVYDVCDDQEI-QKRLAEQQDLQRDIEQHSAGVESVFNI-CDVLLHDSDAC 6097
I+ ++ V D D EI Q + ++ ++ + V S+ ++ C +L++
Sbjct: 753 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN----- 807
Query: 6098 ANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER 6157
A T+C ++ + R + + + R +K E K LD S +D L S
Sbjct: 808 AEGTDCLEAKEKVHVIGNRLK-LLLKEVSRHIKELE------KLLDVSSSQQD-LSSWSS 859
Query: 6158 TAACPNSSEVLYTSAKEELKR 6178
S V TS + R
Sbjct: 860 ADELDTSGSVSPTSGRSTPNR 880
Score = 45.8 bits (107), Expect = 0.001
Identities = 96/461 (20%), Positives = 167/461 (36%), Gaps = 79/461 (17%)
Query: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLS-HH 3823
++Q + R +L + V +++ + S W+ + LA P YDS +
Sbjct: 27 RWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQR 86
Query: 3824 ASTVQMALEDSEQKH--------NLLHSIFMDLEDLSIIFETDELTQSIQELSNQ---VT 3872
Q L+ +KH NL + D + + E D + Q+ + L + +
Sbjct: 87 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 146
Query: 3873 ALQQ----KIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLK 3928
A+ KI E+ Q+ DD E +KS E+ + + S I+ + EE
Sbjct: 147 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS---SGVIYTVAKEE--- 200
Query: 3929 HGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQN 3988
L+ ++ + E ++ +L L + L RT+ +++ Q +
Sbjct: 201 -----LKKFEAFQRQVHECLT---QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWD 252
Query: 3989 EL----------LKVVIKQTNEWDEEIENLKQILNNYSAQF-SLEHMSP-DQADKLPQLQ 4036
L LK I Q E++ +++ L Q ++EH S D K+ QL
Sbjct: 253 NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL- 311
Query: 4037 GEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAER 4096
+ +Q +SLN K + ++ ++ + L E D L E G ER
Sbjct: 312 ----KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 367
Query: 4097 DASER-KLNRRGSMSYLAAVEEEVEESSVKSD------NGDEKAEPSPQSWSSL------ 4143
+ +L L+ E E+E+S+ SD + D P P S SL
Sbjct: 368 YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 427
Query: 4144 -------------------WKHDKDMEEDRASSSSGTIVQE 4165
W HD D+ D S+ S + E
Sbjct: 428 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSE 468
Score = 45.4 bits (106), Expect = 0.002
Identities = 155/846 (18%), Positives = 325/846 (38%), Gaps = 147/846 (17%)
Query: 4913 ELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972
E+E ++ K+ ++W L I + +L+ L + +++ L WL H + +
Sbjct: 16 EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL---AHIESELAK 72
Query: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLH-----LKETDTATLR 5027
+ S + + I+ +N E +++++ S+ +V+++ LLH + + +++
Sbjct: 73 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 132
Query: 5028 ASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHS 5087
+ +++W + + + K+ + + W+ S E +
Sbjct: 133 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK------SSERTAAF 186
Query: 5088 PSSASQV----KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEH 5143
PSS+ + K L+K + F+ ++ ++ +N+ +L+ R RT+ A
Sbjct: 187 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACS 239
Query: 5144 LGEM----NRQW----HRVHGMLNRKIQHL-----------EQLLESITESENKIQILNN 5184
L +M N++W RV +L R+++H + +L +TE + ++ + +
Sbjct: 240 LKQMVHEGNQRWDNLQKRVTSIL-RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
Query: 5185 W----LEAQEERLKTLQ--------KPESVISVQKLLLDCQDIENQLAIKSKALDELKQS 5232
+ ++A+ ++LK Q K E +I+ + L++ + AI + LDEL++
Sbjct: 299 FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE-PLDAAIIEEELDELRR- 356
Query: 5233 YLTLESGAV----------PLLEDTASRID-ELFQKRSSVLTQVNQLKTSMQSVLQEWKI 5281
Y G V PL +D D EL + S+ L+ ++ S S+L
Sbjct: 357 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS---- 412
Query: 5282 YDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQ----------VENLQSLQDEAESSE 5331
Q +++ + + S++++ + +E+ S +E E
Sbjct: 413 -PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
Query: 5332 GSWEK---LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWK 5388
G +K L+ +G + P E + +N K + + A+ Q++ QL K
Sbjct: 472 GQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR------QLGK 525
Query: 5389 AYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL---PPALQDIKELQHDVQKTKEA 5445
A ++ + +K + S ++L ++ +K L+H +++ +E+
Sbjct: 526 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 585
Query: 5446 F----------LQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFV 5495
Q + V+DR L +A L K L +K N
Sbjct: 586 LPGFVNLHSTETQTAGVIDR-----------------WELLQAQALSKELRMKQN----- 623
Query: 5496 LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLN-HVLALTAQSPDIEHLNEV 5554
L +++ F L S+ + EE L++L + E + + L ++H +
Sbjct: 624 LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAI 683
Query: 5555 SLKLPL------------SDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYC 5601
L + L S L MN +W R + E LQ + + F
Sbjct: 684 ILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEM 743
Query: 5602 CEKWIQLLEKIE----EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQ 5657
+ +LE I+ E + +D L + K ++ E+ +Q S S Q
Sbjct: 744 SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 803
Query: 5658 LLDTTE 5663
LL E
Sbjct: 804 LLVNAE 809
Score = 44.3 bits (103), Expect = 0.004
Identities = 65/322 (20%), Positives = 128/322 (39%), Gaps = 27/322 (8%)
Query: 5625 PELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI------TEFSKLT 5678
PEL K Y L E S + DS +L + E E+ P F+ T+ + +
Sbjct: 549 PELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGVI 603
Query: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTR 5738
DRW+ ++ + +++WQ F + + +++ +L DT L ++ E + QT
Sbjct: 604 DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
Query: 5739 SL-IHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQ 5797
L I +LK + R+ L++ D K + R+SQ+ W +
Sbjct: 664 ELQIKKLKELQKAVDHRK-AIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722
Query: 5798 LAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLP-------ELHEDLHNEKEL 5850
L E Q + + L L+ + + + +P E+ +D H +
Sbjct: 723 LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQ--- 779
Query: 5851 IKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQ 5910
+ +++ L + LQ M L + D + KE++ + + + L V+ +
Sbjct: 780 LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
Query: 5911 EIEDRLNTWVVFNEKNKELCAW 5932
E+E L+ + ++L +W
Sbjct: 840 ELEKLLDV----SSSQQDLSSW 857
Score = 41.2 bits (95), Expect = 0.036
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
Query: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 666 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 721
Query: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
L++E L + + + E +LL EN D +VP
Sbjct: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
Query: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 782 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 829
Query: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
LL++ + I+E E L + +S Q
Sbjct: 830 LLKEVSRHIKELEKLLDVSSSQQ 852
Score = 38.1 bits (87), Expect = 0.31
Identities = 122/752 (16%), Positives = 279/752 (37%), Gaps = 88/752 (11%)
Query: 5020 ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQT 5079
E+ + + L + +W L+ + +KL + + K ++ + +W+ ++E +
Sbjct: 11 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
Query: 5080 SDEDSVHSPSSASQVKHLLQKHKEFRMEMD-YKQWIVDFVNQSLLQLSTCDVESKRYERT 5138
+ + V+ ++ +++ L + +E + +++ + + +N + L CD + E
Sbjct: 71 A-KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 129
Query: 5139 EFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQK 5198
+ ++R+W + M + +E+ + + +WL++ E
Sbjct: 130 SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 189
Query: 5199 PESVISVQKLLL--------DCQDIENQLAIKSKALDELKQSYLTLESGAV-PLLEDTAS 5249
+ +V K L + QL + +K L + T + ++ ++ +
Sbjct: 190 SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
Query: 5250 RIDELFQKRSSVLT-------QVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEH 5302
R D L ++ +S+L Q + +T+ S+L W E+++ +EH
Sbjct: 250 RWDNLQKRVTSILRRLKHFIGQREEFETARDSIL-VW------LTEMDLQLTN----IEH 298
Query: 5303 SKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC----PSVAEIIEEK 5358
S ++ +++ L++ Q E + K++++I + + L P A IIEE+
Sbjct: 299 -----FSECDVQAKIKQLKAFQQEISLNH---NKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
Query: 5359 -------CQNTHKRWTQVNQAIA------DQLQKAQSLLQLWKAYSNAHGEAAARLKQQE 5405
CQ R + ++ + D+ + L+L + + + R
Sbjct: 351 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
Query: 5406 AKFQQLANISMS------GNNLAEILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ 5458
Q +N+S+S P ++ I E HD +++ S L +
Sbjct: 411 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
Query: 5459 PAESSTHMLLPG---------PLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESL 5509
+ L G P E + + + + SQ + G L+
Sbjct: 471 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
Query: 5510 KGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ 5569
+ I E + E S+ ++ L S I+ + + KL + ++
Sbjct: 531 RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 590
Query: 5570 NMNRQWIRATATALERCSELQGIGLNE--KFLYCCEKWIQL--------------LEKIE 5613
N++ + TA ++R LQ L++ + +KW Q E++E
Sbjct: 591 NLHSTETQ-TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649
Query: 5614 EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE 5673
+ +++++ + + Q K K L+ V + I S S + E+R +
Sbjct: 650 QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDR 708
Query: 5674 FSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDF 5705
S++ RW + + +G + + Q Q F
Sbjct: 709 LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 740
Score = 37.0 bits (84), Expect = 0.68
Identities = 57/288 (19%), Positives = 105/288 (36%), Gaps = 51/288 (17%)
Query: 5150 QWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLL 5209
+W + K ++Q L+ + + + + WL EE L+ LQ+ E +Q +
Sbjct: 605 RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664
Query: 5210 LDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLK 5269
L + ++ KA+D K L++ P S+ Q R L+Q+N
Sbjct: 665 LQIKKLKE----LQKAVDHRKAIILSINL-CSPEFTQADSKESRDLQDR---LSQMNGRW 716
Query: 5270 TSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES 5329
+ S+L+EW+ Q + L Q E
Sbjct: 717 DRVCSLLEEWRGLLQ---------------------------------DALMQCQGFHEM 743
Query: 5330 SEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL-WK 5388
S G L+ + + + P + + E Q+ HK+ Q+ + + + SL + +
Sbjct: 744 SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 803
Query: 5389 AYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436
NA G K++ + + GN L +L + IKEL+
Sbjct: 804 LLVNAEGTDCLEAKEK---------VHVIGNRLKLLLKEVSRHIKELE 842
>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform 2
[Homo sapiens]
Length = 429
Score = 814 bits (2102), Expect = 0.0
Identities = 415/429 (96%), Positives = 415/429 (96%), Gaps = 14/429 (3%)
Query: 6493 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 6552
MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS
Sbjct: 1 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60
Query: 6553 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI
Sbjct: 61 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
Query: 6613 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6672
ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV
Sbjct: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
Query: 6673 DSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 6718
DSWRGGLRQSLMQCQ DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD
Sbjct: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
Query: 6719 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 6778
PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ
Sbjct: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
Query: 6779 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 6838
LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES
Sbjct: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
Query: 6839 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 6898
RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
Sbjct: 361 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 420
Query: 6899 RYTNGPPPT 6907
RYTNGPPPT
Sbjct: 421 RYTNGPPPT 429
Score = 40.8 bits (94), Expect = 0.047
Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)
Query: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
A I ++ + DRW+ + K+K+ +QQL+ ++S + TWL + E+EL
Sbjct: 53 AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 109
Query: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
+ D QEI+ R+ Q++ + + + A V SV L + E +
Sbjct: 110 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 169
Query: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
+ + + WR S+ + + R F D+ + WL SA+
Sbjct: 170 SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 229
Query: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
P + + EL + E +++ ER Q++++ + L + +
Sbjct: 230 QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 286
Query: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
++ VH ++ L+ +V+ L L+ N
Sbjct: 287 AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317
Score = 35.0 bits (79), Expect = 2.6
Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)
Query: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
ELH + ++L N D +T WL+ ++ L K D+ I + E
Sbjct: 73 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 130
Query: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
K D +L +V + L + ++ L++ L Q W
Sbjct: 131 LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 173
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 234 bits (596), Expect = 3e-60
Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)
Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
+N I + + S K LPG +Q S++Q E +QES + +LE++
Sbjct: 1012 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1071
Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
+ K E+ S + N + ++N ED R + +++ PLE D +
Sbjct: 1072 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1129
Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
+ ++ E EKL +LE K + + E ++ + +VL N+
Sbjct: 1130 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1189
Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
S+ ++D L + LK N ++ +++ ++ L E A++ DK +++
Sbjct: 1190 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1238
Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
+ +K++ + +++++ L+ + + +M K E + QL
Sbjct: 1239 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1297
Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
W+ V QI + + + + +DT L Q ++ + +E S
Sbjct: 1298 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1353
Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
L T L K S E++MK+ ++ +K E +K +
Sbjct: 1354 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1406
Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
+Q K R +M+ + +L L + + K D + ++ +S
Sbjct: 1407 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1463
Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
L EE K+ V + S+++ TL+D + K S+++ K E+ S
Sbjct: 1464 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1523
Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
I+ F +QES L+ + +++ + T ++K +
Sbjct: 1524 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1583
Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
Q+E +E GI L + N + E + D +LK + + +Q+ +Q +
Sbjct: 1584 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1641
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
+ +K F L+E + + Q ++ L+ Q++N+ +K E NLK D
Sbjct: 1642 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1695
Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
++ TAIK + Q+ + K + + L+W S +D+ + K K++ I+Q
Sbjct: 1696 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1750
Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
T F+E GK AI + + ++ D + + N L+Q+ +K K
Sbjct: 1751 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1799
Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
++II ++++ + + ++L K L+ EE +KL K ++ + + E + E ++
Sbjct: 1800 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1856
Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
K + Q++LE + + LQQ L NLE I + + ++F E V
Sbjct: 1857 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1916
Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
+ ++ +T + + + S+ +V+ KL D L + +
Sbjct: 1917 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1976
Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
+ N L D + Y++A + + + EA + P VD N + LE Q
Sbjct: 1977 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2036
Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
++ S ++ L + ++ S AK +Q TL ++V + + ++ + + +
Sbjct: 2037 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2096
Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
L + +++ + +E+ L + +PL+ + + ++ L ++ +
Sbjct: 2097 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2155
Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
+ + + ++ + L + L ++ KE EELK + +
Sbjct: 2156 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2212
Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
+ +NL E+L +TK A TE ELS+ + + ++ E+ + +
Sbjct: 2213 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2264
Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
+L +LL + S +P V ++ ++ ++ ++ +++ KE V + ++
Sbjct: 2265 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2317
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
+F + +LK++ ++TT + E + E+ + + +K L I +
Sbjct: 2318 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2377
Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
I + + V PA+ + V+ L + +E +N+ L S S Y
Sbjct: 2378 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2437
Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
++ KI E+N L ++K ++ S ++ Q++ K W
Sbjct: 2438 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2497
Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
EL +K+ EL ++ +++E++P +A W L ++Q+++Q
Sbjct: 2498 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2557
Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
R +L +++ + ++ + + W+ +++ P D L+ VQ+ L+
Sbjct: 2558 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2616
Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
+ + + + LS E L ++E VT + L D
Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2676
Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
+ ++ +S+ + +S + L +K + H LE + MK+ I
Sbjct: 2677 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2729
Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
Q K + V Q + L + E + E + L+ ++K + +++ EN Q
Sbjct: 2730 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2783
Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
L + A + MS D L + E + L+ E L+ D K + L
Sbjct: 2784 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2842
Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
H+ ++ + L E + + K N + E +++ES K+
Sbjct: 2843 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2902
Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
E+ E W + K ++EE + + +NS+A++ SL
Sbjct: 2903 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2945
Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E + N T E D +D L +V+ TE LH+ K +
Sbjct: 2946 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 3001
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
+ Q+ E Q E+ + L+ K+Q + D+
Sbjct: 3002 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3033
Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
+Q + L+T + +L+ K Q+ L ++ ++D ++ ++S+ + + L
Sbjct: 3034 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3085
Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
++E+I E S+Q D ++ LE K F I ++M+ Q+ + D++
Sbjct: 3086 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3139
Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
++P G++ + Q + + +K +E +++N
Sbjct: 3140 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3176
Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
+ M T+ +L LE L ++ + L + EE K+L E + L +
Sbjct: 3177 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3235
Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
+L+ + E + ET+ +L + ++ L + + W G+
Sbjct: 3236 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3292
Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
+T L D++ + R+ L+ L + +Q+ ++ L ++
Sbjct: 3293 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3352
Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
++ + Q + V Q+Q+ L++ +S V ++ EGE++ +V
Sbjct: 3353 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412
Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
L+ + LDS W L R +L V Q L+ + E + +++L +
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472
Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
+Q AL+ I NH + V+ ++ S++ ++Q++ F
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3530
Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
QV ++I +EKS LQ L + F E+ L L + L +S+ + + E L
Sbjct: 3531 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3589
Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
++ S + ++ +I + + Q L G +L+ + E ++ ++ ++ ++ + K
Sbjct: 3590 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3649
Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
L+ L+ + ++L WL+ + L ++ Q L + +R
Sbjct: 3650 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3706
Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
E KE +L ++ + + LL L L +A+ +++ ++ + E
Sbjct: 3707 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3764
Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
++ + +A +SW+ E + + + + LQ K F ME +
Sbjct: 3765 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3822
Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
+K I D V ++ C E K+ + + + L E Q R ++
Sbjct: 3823 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3882
Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
N+ + E+L +TE+++ I + L A +TL Q+ E +++L+ + + +
Sbjct: 3883 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3938
Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
++ L EL ++ Y+ ++ + ED R +DE + + +++
Sbjct: 3939 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3998
Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
Q+ S++ +++ + + EV + + + +K V + +E L+ E L+ +E
Sbjct: 3999 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4054
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
+ G +K A+ +++K W ++ + ++ K +++L
Sbjct: 4055 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4102
Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
+ + H +K + + L + + + + + A + I+E +Q+ +
Sbjct: 4103 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4161
Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
+ S L +P + L SL +A LE+ +
Sbjct: 4162 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4221
Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
F++V L+ G LE++K I ++ +QQ+ E LNH L
Sbjct: 4222 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4277
Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
++ + E S K + D L + W + R +L+G L +F + +
Sbjct: 4278 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4330
Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
+ + L E L P+ +E + + +L+ +V +Q+ ++ L+++
Sbjct: 4331 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4390
Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
+ E + L RWQN ++ QRK +DG +RQ + F +E+L ++LTDT
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450
Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
L A K L E N + F+ + T ++ G+++L +
Sbjct: 4451 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4505
Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
++ + I+ L++ W+ +E +L E + + + E + + I L Q L S
Sbjct: 4506 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4565
Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
L + + + + + K + S + + EL L +DV+++K +
Sbjct: 4566 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4623
Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
+ +WE + R+ R + ++D F+E +L WL + E + +I+ +
Sbjct: 4624 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4683
Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
K Q K+ + + + G L K S ++DD L+++ D+W +
Sbjct: 4684 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4743
Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
R KL+E F Q + L WL R+E +L+ +PV D+ + +
Sbjct: 4744 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4800
Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
+ Q+++ + ++ V+++ L+ S + ++ + L RW +CA+S+
Sbjct: 4801 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4855
Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
++ ++E R ++F +WL AE+T P+ + L T + + + F
Sbjct: 4856 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4911
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+++ E+ +L + D+ + +K + R++ + +RL
Sbjct: 4912 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4971
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
+ E++L WL + LT+ + ++++ L F +E+T
Sbjct: 4972 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5031
Query: 6299 KIDQL 6303
+D++
Sbjct: 5032 DVDKV 5036
Score = 197 bits (500), Expect = 4e-49
Identities = 113/266 (42%), Positives = 148/266 (55%), Gaps = 35/266 (13%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT WIN L + ++DL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 61 ERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 118
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +L+ R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 119 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 169
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S MSA++ LLLW Q+ Y + +F
Sbjct: 170 -------DIHVTGESE----------------DMSAKERLLLWTQQATEGYAGIRCENFT 206
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
+ WR+G F AIIH RPDLIDM +V +SN NL AF +AE ++ + RLL+PEDVDV
Sbjct: 207 TCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPEDVDVS 265
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE 293
PDEKS++TYV+ P GE
Sbjct: 266 SPDEKSVITYVSSLYDAFPKVPEGGE 291
Score = 193 bits (490), Expect = 6e-48
Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)
Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
N EE N FV L+ D +Q ++ + + ++ ++ +A+E+F +SL+
Sbjct: 626 NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 685
Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
AK+ S+ Q+ LT K +H ++ + K+L+ S ++ ER
Sbjct: 686 EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 725
Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
DT + A + I L+E V +++E N + + EL++ NI+
Sbjct: 726 HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 785
Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
VQ ++ L++ + +R + +L + ++H++E F D +E
Sbjct: 786 SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 845
Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
T C + + + LV E +E+ +L+ N T+I
Sbjct: 846 ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 904
Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
Q S L+ S K R EI I K++ N H K +
Sbjct: 905 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 961
Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
+ F PP KEA +D+ + E Y+N+ L LW + N+K+V+ W
Sbjct: 962 MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 1009
Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
+ + E DR R + E + ++ +Q + E E QV S
Sbjct: 1010 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1061
Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
+ ++E V C + ++L ++ + ES+ L S+ I
Sbjct: 1062 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1106
Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
+LE + ++++Q + + L + +T E +LKK+ E + D T + ++ FS+
Sbjct: 1107 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1165
Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
+ + + N+ + + S T K+K V+ V
Sbjct: 1166 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1206
Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
LK+ + + L K + +L ++ + +E + S + E+++ Q L+D+
Sbjct: 1207 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1264
Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
L+K +E +K +E + + + E++++V Q++N L++ G + +
Sbjct: 1265 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1323
Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
+ +D + +T R++ E + E K L T+ L ++ E+K+S M
Sbjct: 1324 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1377
Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
E + E+ +K+ L A +++ + ++ S A L+ + D+
Sbjct: 1378 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1434
Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
++ + L + Y L +EK L E +K +++ ++L+ + LK ++
Sbjct: 1435 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1494
Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
AG + ++ K+ L +A L L G+ + + +N + L+
Sbjct: 1495 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1552
Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
+ L L+QLQ+S + D V +E+ + DL T +N +E
Sbjct: 1553 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1612
Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
D V+ + K ++LQ+ G+ + + + K+ + G+K+ ++D
Sbjct: 1613 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1665
Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
K+L +E +L AK + C LK+++S ++ +K T+ ++E T++
Sbjct: 1666 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1708
Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
AAV++LEE DW N D E A +K + Q +S EDE
Sbjct: 1709 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1768
Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
N L+ ++D + Q E + + Y +++A+ I Q + T++ ++L
Sbjct: 1769 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1823
Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
G S + + L + + LK + E+ LA E MK + +E L+
Sbjct: 1824 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1873
Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
D + L + ++ + ++E D + L K E++ +H +T ++
Sbjct: 1874 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1933
Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
LE+ + +V+ +++Q+K + + N + + L + QH
Sbjct: 1934 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 1993
Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
L L++ E A + D LQ L+GQ Q + K+
Sbjct: 1994 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2053
Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
K +++ ++++ ++E L E ++ + +++ + E +
Sbjct: 2054 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2113
Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
W N+ L +PL + I K + I RQ S+ ++ E+VK + +
Sbjct: 2114 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2173
Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
S L ++DL ++ K + ++E +L+ + F + + E++T +
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2232
Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
V+ + +E H LE L+EI S G+ + + + E+
Sbjct: 2233 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2289
Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
N + F +ED +K K Q + V+ + ++ +K +Q
Sbjct: 2290 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2349
Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
E+ +Q L E+ N G+ + NL +T I V V +
Sbjct: 2350 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2407
Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
G N + + + T + ++ L++KI +L+T + K Q +
Sbjct: 2408 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2464
Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
A+ ++KM + K A + E + L Q + K + L D++ +
Sbjct: 2465 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2524
Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
L EN ++ + K++L E D ++ L + ++ K + N + +T
Sbjct: 2525 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2578
Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
L Q ++ +L +L ++++ + ++ + ++ + +TA I +
Sbjct: 2579 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2638
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
E+ S V+ +L L + R + ++ A T+Y+ + + ++ L
Sbjct: 2639 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2698
Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
+ ++ + D N + LE + ++E++ I Q L E L A +
Sbjct: 2699 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2750
Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
+ +Y EL + + ++FK E +AE ++++ + +++M D + ++T
Sbjct: 2751 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2807
Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
+ S P+S + + LE L + SK L + ++ + + + LL+ + +E
Sbjct: 2808 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2865
Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
+ L L + W+ K+ +E W C+ +E K
Sbjct: 2866 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2925
Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
F + E E I L +LQ+E+ + + + + T+E L+
Sbjct: 2926 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2985
Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
+ E + ++ L + Q+ + Q V + S A E + + S +
Sbjct: 2986 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3045
Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
+LQ QK+ + ++ ++ ++++ + + T+ + Q+H S+Q +E
Sbjct: 3046 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3105
Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
S L+ +G F+N + ++ +++E + A + E +K E I + E
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3165
Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
L +S A M EE + L ++E + +Q +K +++AQ ++++
Sbjct: 3166 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3225
Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
L+ ++SKL E +Q E + Q M+ I P Q QQ
Sbjct: 3226 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3285
Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
++++ R +QL +A + + D L+
Sbjct: 3286 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3345
Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
S +W+ +T L+AN A++ ++ +Q L+D + + + I + E +
Sbjct: 3346 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3402
Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
+ E + + +++LS ++ AL K Q++ ++ ++ + + ++
Sbjct: 3403 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3462
Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
I+ L++ E EE + + + ++I K + + VS L++ +
Sbjct: 3463 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3522
Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
V + + ++ + ++ELL+ + + E+ L LN + S +
Sbjct: 3523 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3582
Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
+ L + Q E+ +++ IL Q + L++ LK T + ++ + E + +
Sbjct: 3583 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3641
Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
R +T VA+ +L RR ++L VE E+ + G+E +A
Sbjct: 3642 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3701
Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
+ P+ K++K + + SS + +E K+ DN ++++ +
Sbjct: 3702 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3761
Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E+ LR Q ++ ++DA+ EK +
Sbjct: 3762 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3798
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
++ L Q + ++ +Q+ +++ + ++ ++ ++ C ++
Sbjct: 3799 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3845
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
E +++ KL V N + + + E++ + + L ++E L P L+E
Sbjct: 3846 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3899
Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
+SI+++ P + RQ+ + +Q+ EL E K I K PQ + +
Sbjct: 3900 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3954
Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
+ QE +A S + DV D +S Q DK + L + +L P
Sbjct: 3955 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4014
Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
+ ++ Q+S N + + Y T ++ K +
Sbjct: 4015 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4074
Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
L+ + N+ T E ++ L +K + L +T+ + + LE P +
Sbjct: 4075 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4133
Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
QQ ET+ E+ L L + +L+ A P + ++ + D L
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4191
Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
+ A R L+ + YQ+ ++ ++ + + S + + L + Q
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4251
Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
+ K++AY ++E AE + K+ +E ++ + + + +L+ + DS+
Sbjct: 4252 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4307
Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
+ R +L + Q Q AL + + L + ++K G K + ++A ++
Sbjct: 4308 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4367
Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
N + Q V A LI++ SA S LQN+ ++ V EK+ Q +
Sbjct: 4368 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4423
Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
L L++ + F L++ L L+++ P L E +E+L + + ++
Sbjct: 4424 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4479
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
K + +G+Q++A CP+ ++ I L+E+W S+ K++ +L+ L
Sbjct: 4480 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4537
Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
+ ++ WL ++ TLN SL LDT+ I+ F+ EV +S
Sbjct: 4538 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4590
Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
+ +I + HLK + D ++ L + +W ++ +L + L +
Sbjct: 4591 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4650
Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
+A ++++ W+ E + S + + + ++K L +HKEF+ + K + D N
Sbjct: 4651 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4708
Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
++ L + S + + + L E+ +W + G + LE+ L + + +
Sbjct: 4709 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4766
Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
Q L +WL E +L Q I V L+ + + + +L ++ ++ LK+S L
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4826
Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
G+ D +S + Q+ S+ V L S Q+ L+ + + V + +
Sbjct: 4827 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4880
Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
+ ++ + L + L++L D+ + E+ + + K + +V I
Sbjct: 4881 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4939
Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
T K W + +A +++ Q A + A A L + + Q A +++
Sbjct: 4940 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 4999
Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
+ E++P ++++K L + Q E + +D++
Sbjct: 5000 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036
Score = 179 bits (455), Expect = 7e-44
Identities = 674/3683 (18%), Positives = 1386/3683 (37%), Gaps = 526/3683 (14%)
Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
E +LEN+K + E+ ++L + + Q + L L+Y E L RLE A L++T
Sbjct: 664 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 720
Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
+ L R T +W E A +W + ++ K
Sbjct: 721 RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 769
Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
E+ RE LD +E + + + E E L + Y ++ Q + L Q
Sbjct: 770 HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 825
Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
+ Q++ E++ E +E T +Q+ + K ++LVQ ++E+
Sbjct: 826 VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 883
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
+ + N + T Q P S+ K + + I + +I+
Sbjct: 884 EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 931
Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
TI + +A + NE + S + + N ++
Sbjct: 932 I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 983
Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
++Q+ +N+ + WH +NE+D S V I PG+ Q+ + NL
Sbjct: 984 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1043
Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
F+ + + SQ ++ + +QL K V + Y +LLKS E + S ++ +
Sbjct: 1044 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1103
Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
+R L + + + ++ +L S+F E + E + L + ++N+
Sbjct: 1104 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1163
Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
Q S+P ++ + V+ ++V SM + K+KT+ L + E E
Sbjct: 1164 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1223
Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
L E ++ + ++ I+ + ++ E+ + VF LQ K + +
Sbjct: 1224 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1273
Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
E+ K ++ ++D E Q++ + H+ D ++L L+G I + K
Sbjct: 1274 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1324
Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
+D + ++ T + +++ Q + + ++ V+E + + K++
Sbjct: 1325 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1380
Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
++ + Y A V++ E++ + ++ ++ P ++ R SS+ I+
Sbjct: 1381 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1426
Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
QE + + T ++ ++T DSL + E SL +
Sbjct: 1427 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1485
Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
E+ PP + S + E E T E E+
Sbjct: 1486 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1545
Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
KT L ++ +V VE E + A+ QQ +++L G +LT+ E
Sbjct: 1546 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1604
Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
H+ AF++ E K Q + Q + + + L V N E EK S
Sbjct: 1605 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1662
Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
++ I +K +E + + + +NL EL+ +VT + +K +Q+ E K
Sbjct: 1663 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1720
Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
+ D++ ++ ++++ ++ Q N T + A E++V N
Sbjct: 1721 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1770
Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
G+ L+E V +G TTQ E+L
Sbjct: 1771 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1789
Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
Q+ ++ Q +++ + + + ++ L S EE ++ + +E +V
Sbjct: 1790 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1845
Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
HYET LA S+KK L ++ LE FD EH + +
Sbjct: 1846 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1890
Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
+L+AG D ++KR +I K L+ ISG V A+ K D V
Sbjct: 1891 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1948
Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
+ V + D +R Y+ + L+D++D Y + S +
Sbjct: 1949 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 2003
Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Q + + + E + + + L L++TK ALQ QI + +V +KL ++
Sbjct: 2004 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2059
Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
+LP+ ++T + V + L + + KLQ L + + + +
Sbjct: 2060 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2118
Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
+ S+L V L + IS ++++I G+ + + + K+ + + +
Sbjct: 2119 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2178
Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
L+ ++ L ++ + K L +++ L + + S++L +LE+ L
Sbjct: 2179 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2238
Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
+V++ ++ + + F E K ++ SL + S H +D A +
Sbjct: 2239 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2292
Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
+K+ + + + +E + Q + + + + SW+ +T+ + + PS A
Sbjct: 2293 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2348
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
+ L+ K+ + + K + VN S + L + + E
Sbjct: 2349 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2408
Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
EF + G +++ + + +L KI L L + +++ + +
Sbjct: 2409 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2468
Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
WL+ + Q+ P +V+ + + E +L + ELK L
Sbjct: 2469 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2528
Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
++ P + + ID +Q+ R L + + T Q+V L++W + +
Sbjct: 2529 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2588
Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
L V P+ + L Q + +Q L E + + +E+L Q +
Sbjct: 2589 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2635
Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
+ + G PS+ I++E+ ++W + ++D+ + Y + + +
Sbjct: 2636 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694
Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
L + K +S + + + L A + +E+Q + ++ K +A ++ S L + +
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2753
Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
++ L G L S Q+A +++ + A+ +F +DF L++ K
Sbjct: 2754 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2809
Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
EE+N LD L K++ D LTAQS E + LK S
Sbjct: 2810 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2863
Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
+ A LQ + W ER ++L+ EK L E+ WI +
Sbjct: 2864 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2921
Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
E +K + NS+ +L QK V + A+S LL EI+
Sbjct: 2922 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2972
Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
E +T+ +K L + + + +K ++ + +++++F + R L L
Sbjct: 2973 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3032
Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
++ Q + Y T + + + K + + + A L A + ++ +D K V ++
Sbjct: 3033 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3088
Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
+ + Q+ E ++ ++ + I+E+ S+ + S P+ E
Sbjct: 3089 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3148
Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
L +KE IK + L A N +T K L D++ +K +E L +Q L
Sbjct: 3149 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3208
Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
R R++++E + F K KE L + E + +E M +
Sbjct: 3209 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3268
Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
QK EEI + + +G LI+++ KS + + ++ L+ +N RW+ L +
Sbjct: 3269 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3325
Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
R +L+E + + +L +W+ E EL + + ++ ++ EQ+ LQR
Sbjct: 3326 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3384
Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
++ + VE V+ + + A E D ++ + LD RW + + R
Sbjct: 3385 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3437
Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
++E + Q+F + +WL + E+ + +E++ + +A + I
Sbjct: 3438 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3497
Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
++ L Q I + + L+ RE++ S+L + +Q W +Q + + L+
Sbjct: 3498 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3552
Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
+ F ++ WL E+ +L+ +V+ +S + +L Q++I L +DQ
Sbjct: 3553 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3612
Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
++ G +L++++ + ++I+D+LE + +++ + + RRL S
Sbjct: 3613 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3672
Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
CT + E E ET + P+E++ ++ + + + S +
Sbjct: 3673 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3732
Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLK 6457
P R G E V+ D+ + D E D + L + + +A L
Sbjct: 3733 VPWRAREGLEKMVAEDN--ERYRLVSDTITQKVEEIDA-----AILRSQQFDQAADAELS 3785
Query: 6458 MTTKTLKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKL 6517
T+T K K +S G ++E D+ + + + K
Sbjct: 3786 WITETEK----KLMSLGDI---------------RLEQDQTSAQLQVQKTFTMEILRHKD 3826
Query: 6518 LLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQ 6577
++ D K G +++ ++E + ++ +D I ++ + + +
Sbjct: 3827 II---DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3883
Query: 6578 QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVN 6637
Q + WL +T++ + L P + + + + + +++ + +K + +N
Sbjct: 3884 QFWETYEELWPWLTETQSIISQL--PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3941
Query: 6638 VSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLL 6697
+ + L+ E +Q + L+ + V L +++ Q FH +L
Sbjct: 3942 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4001
Query: 6698 LWLASAKNR-RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 6756
L R RQ ++ A+ + E E + ++ + QP + L++ ++ +
Sbjct: 4002 ESLERIVERLRQPPSIS---AEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4058
Query: 6757 GHGEDCIEAEEKVHVIEKKLKQL 6779
G D + ++ KL Q+
Sbjct: 4059 SGGTD---KDISAKAVQDKLDQM 4078
Score = 174 bits (440), Expect = 4e-42
Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)
Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
LQ Q E K F +KL A ++ + K +L ET + V + LE S+QC
Sbjct: 3150 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3206
Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
LL + + +E K LE S L S+ L+++ +++ + +G +
Sbjct: 3207 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3256
Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
+ Q LN +GKQ S S LE + + +W
Sbjct: 3257 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3316
Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
+LNKK+ +LQ L H + + L W+ ++ + K S + ++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3372
Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
+ I + +D++ S + G ++ E D + L+ + +W L+ +
Sbjct: 3373 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3432
Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
+L + + + + + W+ +E + + + + + AS+++ + +HK
Sbjct: 3433 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3490
Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
++ ++ + + V+ QSL LS+ + + + +F++ W+ + +
Sbjct: 3491 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3543
Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
+ + L+Q L + E++++++N WL ++L L Q+ E + +
Sbjct: 3544 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3602
Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
+LL Q+++ L L+ LKQ+ V +++D I ++ + + T V +
Sbjct: 3603 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655
Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
L+ ++Q + +++L ++ + + + + V+ E + Q+ + L+ E
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3711
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
A++++ + L EV L L P A E +E+ ++R+ V+ I ++++ + +
Sbjct: 3712 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3771
Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
+ + A + + + E K L +I + QD Q VQKT
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3819
Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
L++ ++D L + S H ++ S + ++K L ++ + + +
Sbjct: 3820 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3873
Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
+LE + L+ E + L E S ++ + A + + E +L
Sbjct: 3874 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3932
Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
K + MN+ T L S +G + EK++ + Q+ E + +EA+
Sbjct: 3933 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3987
Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
K+D + SL ++E+ + + AEV I + I++ S + LQ L T
Sbjct: 3988 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4047
Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
++ R E + S TD+ +A + + +D +V W++ T VE
Sbjct: 4048 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4102
Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
+F D L+ +K + F S+ + + E +EI + +
Sbjct: 4103 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4162
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
L G +L+ K V + I +L +W + + I + + ++ Q + ++
Sbjct: 4163 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4220
Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
+ + + + P + DL K+ I+EL+Q + Q E++ + +A+L
Sbjct: 4221 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4279
Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
+ E D +++ + L W+ L R+ R+ ++E L F EL AWL
Sbjct: 4280 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4339
Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
E + + + + IE + ++ L ++ ++ + + G+ LI++S A+ +
Sbjct: 4340 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4399
Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
+KL +N RWQ++ + R ++L + + +L+ WL E L SKP+
Sbjct: 4400 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4458
Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
+ + EQ ++ ++ A E+ ++ C E + I Q
Sbjct: 4459 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4511
Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
+L +W ++ ER+ K+EE L +F + F +WL AE+T + ++
Sbjct: 4512 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4571
Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
+ ++ + F +++ Q+ ++K L ++ +K ++ RW+ +
Sbjct: 4572 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4631
Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
+R+ R L + ++F ++ WL E + L + +E ++ D ++ Q
Sbjct: 4632 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4691
Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
FQ+ + + D G L +K+ D L ++D L EL + G+
Sbjct: 4692 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4744
Score = 160 bits (404), Expect = 5e-38
Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)
Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
LT S LS G T+ L + A T G+ + + P+ SL+ KL +I++
Sbjct: 559 LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 616
Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
+L K S++ L E +I L + E++ Q + SDL + + S L++H
Sbjct: 617 LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 670
Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
KN + + +LKE + SE + + KL LE + +K+
Sbjct: 671 ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 720
Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
++ ++HL H +S + L + E + A + + + R +D H L +
Sbjct: 721 RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 776
Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
L +EE K ++E E+ L +A A + Q+ + QL ++++ +
Sbjct: 777 LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 836
Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
E EAT + + +++ + + ED Q + +++ + I
Sbjct: 837 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 896
Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
++++ L PL E I K E +L A+ + I
Sbjct: 897 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 956
Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
+ P V K D++N Q+ N L L + SH + YL ++
Sbjct: 957 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 1014
Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
D +R + K G +H Q + ++ FL+ +Q D+T L KE+
Sbjct: 1015 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1070
Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
Y E K+ E+ L +++ + L++Q++ ++ D H
Sbjct: 1071 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1130
Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
+ E + + + L T+ N +EF S + + +L + + N++
Sbjct: 1131 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1190
Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
T L V +NT + + + K + E + + K +E + S
Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1243
Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
LK RS EK+ F E Q + + ++ L+ DW K D VE +
Sbjct: 1244 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1303
Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ ++ + +S+K D +++ Q ++ Q E + L TQL +
Sbjct: 1304 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1363
Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
K + +E EC E + L + Y A +D+ ++ + ++ + S
Sbjct: 1364 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1422
Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
++++F + Y+ S+K L +++SL+ + V +++K++
Sbjct: 1423 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1482
Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
++I K K KI E +S + + L Q+ +HG + +++ +
Sbjct: 1483 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1541
Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
+ +QV E F+ + ++Q+++ S ++ +++ + R + +E+ +
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601
Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
T+ + H + + G +++K+ ++E+ KN E N LK+
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1658
Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
E L E L+L+AE K+ D + +KE + A L E
Sbjct: 1659 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1718
Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
I L D ++ + H ++ + ++ EE + L T
Sbjct: 1719 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1778
Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
+ T E+L QYQ + V+ +TQ +Q L LE++ + + K +
Sbjct: 1779 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1835
Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
L E + A +E ++K H + Q+EL++ D+ + L +EL
Sbjct: 1836 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1891
Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
E D + L + R + F ++ + HK R + + E A S + +
Sbjct: 1892 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1945
Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
+ ++ V+ ++ + DR ++ KC +L LK + D D S L LQ
Sbjct: 1946 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 2004
Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
K L E I K L EE Q +S + ++KK EV+L A S
Sbjct: 2005 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2062
Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
+L + + K L D+I+ + + + EK + + + D L ++L
Sbjct: 2063 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2113
Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
M +E S KE L+ QD + ++ + I + +N ++K D
Sbjct: 2114 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2173
Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
A Q + S + A K +E ++ +++TK+ FE+L +L T ++ +T L
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2232
Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
+ L++Y +E+ + +E LE + ++ G P + + L K
Sbjct: 2233 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2291
Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
L ++D + EK ++S + +L L+ ++E K ++ +F A++
Sbjct: 2292 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2351
Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
+ LE+ K K++E +++ V +S S + +A+ ++ A+++
Sbjct: 2352 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2406
Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
+T E + L ++ T E+ G+ L ++ L K L +A +E
Sbjct: 2407 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2466
Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
W +++ + +W+ + EA+ Q + E + +EL + L L
Sbjct: 2467 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2526
Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
+ + K Q L L + R + ++ + +TV A ++
Sbjct: 2527 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2586
Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
KE +L + + ++ T+ Q+ +E K ++Q T + Q + + + S +
Sbjct: 2587 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2646
Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
E+L ++ +K + + R + + + + +S + L D+D K+S+
Sbjct: 2647 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2704
Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
+ S+ AM +++E +++ +QQ+ K I+ AQ + + + + + K EL
Sbjct: 2705 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2759
Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
+++ I VEQ + + + Q+QQ+S+ + + + NK+ +
Sbjct: 2760 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2819
Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
K++ L+K E I +LL + L T+ +
Sbjct: 2820 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2879
Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
T ++ AL+ EQ L + +LE++ + E SI +
Sbjct: 2880 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2939
Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
L + + Q ++E L V I+ EV KS+ ++V + L SK+
Sbjct: 2940 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 2999
Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
+ ++ + EV E+ R ++ ++ L + QT K L +
Sbjct: 3000 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3059
Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
+L QD+ + +E + QE + L + V ++ + + +++ +
Sbjct: 3060 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3119
Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
N FS D+ D + + + E ++KQ I + ++ E L+
Sbjct: 3120 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3179
Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
L E+ G++RD L A++ + + +R A R+ G++ L +++E S
Sbjct: 3180 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3237
Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
+ +KAE +S + ME + TI Q+ +M ++
Sbjct: 3238 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3272
Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
+ + QG + + + + +T +E D D + L +V + + E
Sbjct: 3273 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3332
Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
L C V EL Q + E + + A +Q Q L Q+L+ +
Sbjct: 3333 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3392
Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
E+ K+A E K + L EAL K +T LE + ++ Q+ H
Sbjct: 3393 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3450
Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
E L+P+N L+ +E + Q ++Q+ + K +E D
Sbjct: 3451 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3493
Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
I + +H + + SS E+ D+ S L D Q +
Sbjct: 3494 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3534
Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
E+ K L + + + V + N+ L ++ + S L
Sbjct: 3535 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3580
Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
Q+ TE L K+ EL + L +V++ L + +G +V L
Sbjct: 3581 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3636
Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
E +K Y ++ D+ K + + L + L L+ + + + G
Sbjct: 3637 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3696
Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
+ +++ Q K L + K+ +L SLNE+S + +A E E VA
Sbjct: 3697 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3746
Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
++ ER L + Q+V +++ + +A ELS ++TE+++ + G + L
Sbjct: 3747 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3803
Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
+ QT +++ +Q +I HK LV + ++ A S + S+ +
Sbjct: 3804 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3852
Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
+ T +I E+ Q + Q WE ++E + L + + +IS LP+ +L
Sbjct: 3853 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3911
Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
ET + E ++Q++ I + + G QL+ EL G+ ++E++
Sbjct: 3912 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3962
Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
++ L +I ++ + L +S + D++ + LES + + + Q ++S ++
Sbjct: 3963 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 4021
Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
+ I+ I+ S ++++ L + G +++ + A Q + +
Sbjct: 4022 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4075
Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
Q+ I E +H L E+ + E+ W +++ + +D+ + P S
Sbjct: 4076 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4135
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
VK + + R E+D Q +D V N ++ C K + + + E+N W
Sbjct: 4136 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4191
Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
++ +I LE+ +++ + ++ +Q + +W++ +L ++ + + K
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4247
Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
Q IE KS+A + + L A LL+ D EL S+
Sbjct: 4248 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4305
Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
++ + ++ L + DE+ + KPV + + ++
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4365
Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
LQ++ + + + E + + L + A ++ K + ++RW V + + Q+
Sbjct: 4366 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4425
Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
L+ K + HGE L+Q + + LA+ + G E L ++ +
Sbjct: 4426 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4481
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
+ K + +L R P+ AE++ + +++L +R LE+ L
Sbjct: 4482 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4537
Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
+ A EF L F ++ + E + LD + Q E+ F N V + Q
Sbjct: 4538 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4595
Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
+++ HL S K + V +K L ++ +W + +ER L K +
Sbjct: 4596 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4653
Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
E W +L+E +EE+ K +++AN ++ Q +K + + ++ D+
Sbjct: 4654 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711
Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
L + T + ++ + S+L D+W +R+ ++ + FT +++ L
Sbjct: 4712 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4771
Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
+L L+ E ++ L+ L + FQ+ +RT+ L+ + L+
Sbjct: 4772 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4826
Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
V ++ +L W+ + + +L ++Q F S V + + E
Sbjct: 4827 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4885
Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
R + ED L L + KE +K+LE+ A L + TM +
Sbjct: 4886 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4938
Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
+ + +K I + ++E++ +Q + L + E + L AWL E +
Sbjct: 4939 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 4998
Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
I + IE++ K + E F E ++ KQ + + K RAA+
Sbjct: 4999 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5046
Score = 155 bits (393), Expect = 1e-36
Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)
Query: 616 ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
++L + E +L E VE + ++ S+ISK L+ K + SK ++
Sbjct: 1452 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1511
Query: 669 ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
+ L + K D N L K+ K E FS + +
Sbjct: 1512 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1571
Query: 714 QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
++K EK E + E+ +L+ D+ +LIG E + ++ + E
Sbjct: 1572 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1630
Query: 768 ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
E K + E++ +E+ L+ + + +S ++ ++ K+ EAK K +
Sbjct: 1631 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1684
Query: 828 VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
+K + K L V + + ++EES+ ++E+ + + E G +
Sbjct: 1685 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1741
Query: 880 KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
KHK+ + + T K+ +E+ N+ E D+ + ++ +++ + +
Sbjct: 1742 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1801
Query: 935 LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
+ Q + I + + +L+ + Q ++ E+K + K L +E +E +L
Sbjct: 1802 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1861
Query: 994 HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
H ++ EEL E + L+ EQ++E L A +I+ + S +E
Sbjct: 1862 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1915
Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
I T S NR + +K D A ++ L +
Sbjct: 1916 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1973
Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
++ L+++Y Y D L LQ + + S LQ +L + +
Sbjct: 1974 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2033
Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
++ + ++ E + E + NDI+K D + R +L ++
Sbjct: 2034 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2088
Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
N R E L+ L L V+ S L +PL+ A+Q D I
Sbjct: 2089 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2141
Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
+++ QD +Q I N + E ++ P ++Q + +F +H+
Sbjct: 2142 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2200
Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
V+ E+ + L+ FL + L + + VT+LS + E
Sbjct: 2201 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2260
Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
K+ E L+K+ + H DK L + L FK+ E + TSC+ LDAF
Sbjct: 2261 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2320
Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
+ + + +E T++ +++ F +L K+++D + K LK P + V +
Sbjct: 2321 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2377
Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
SL L + + ++ N+ + + ++ + + +
Sbjct: 2378 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2437
Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
E+ L+ + + + L L++ Q S + +QK + + + +
Sbjct: 2438 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2497
Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
+E K E + V+K+ ++ L L + E P K+ +D +W ++N+ T
Sbjct: 2498 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2557
Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
D + L + + ++ + +W EK L L L+ D L + Q +
Sbjct: 2558 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2616
Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
EF+ R + + L + + L + S+ ++ +T + + +L+G ++ + +
Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2674
Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
DQA + +SLL++LS S SL + T +EIQQ+
Sbjct: 2675 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2734
Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
Q K + L E+ + E +EL +Q E + F + ++H L
Sbjct: 2735 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2794
Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
++F W K + S +E ++ DF TL ++ ++ + +
Sbjct: 2795 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2854
Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
++ + L L + + + R +L++SL++ L+ ++ L W+
Sbjct: 2855 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2914
Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
N E+ K +P GE + ++L ++ +Q F V LNN+ KE
Sbjct: 2915 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2974
Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
E + +I + + ++ + ++ E+ +E K
Sbjct: 2975 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3034
Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
+L T+ +S L H V K + + L+V E K
Sbjct: 3035 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3083
Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
+LL+ E A+ + + Q + ++ L I + + + S + ++L
Sbjct: 3084 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3143
Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
+ E + KE ++ L +L+ AL K+ + + DL + +
Sbjct: 3144 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3196
Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
+L++ Q N LL+ + + E+ IK L E S L++ +Q + EH+ Q
Sbjct: 3197 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3250
Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
V T++ F F + + E LQ Q+ N L L +S
Sbjct: 3251 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3295
Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
++TS+ G + DD+ + + K + R A ++ + C L S+L TE
Sbjct: 3296 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3355
Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
+ L +K +++ V+ QE +++L +D E+ K ++A + +
Sbjct: 3356 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410
Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
+ + Q S+ ++ E +N E +N+ LE +++ NE L IEK
Sbjct: 3411 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3470
Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
E LE+ +K ++ HN IG S + L + + K S
Sbjct: 3471 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3530
Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
Q + + QE + ++ L + + ++ + +L+++ ++ + + S L
Sbjct: 3531 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3589
Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
W+ S V D L + + Q L +G E ++Q IQ K Y +
Sbjct: 3590 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3646
Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
T L V T +Q L RL S E +++ + VLKG
Sbjct: 3647 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3699
Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
QA+++ K + E K K L D +N + W E L + AE+ ++ I
Sbjct: 3700 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3759
Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
K++E + W +L I L D +Q++ K
Sbjct: 3760 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3819
Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
IL + ++ L + + + + E + L+ + Y + +++R QLE
Sbjct: 3820 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3879
Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
+ F+ + + E+++ II ++ A E E TL Q+E +++ I+
Sbjct: 3880 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3932
Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
H + + + EL+ E ++++ ++I+ ++ ++ I Q
Sbjct: 3933 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 3992
Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
FH+K + E S++R L Q + + E+ +K++++ K + + KL+ +++
Sbjct: 3993 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4047
Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
+ G + D S +LDQ+ T V E+E +L + ++ + F
Sbjct: 4048 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4107
Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
+H + + DL+ + V+K + E+ R L + ++ L E
Sbjct: 4108 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4167
Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
+I E D +K I ++ D L K ++ + +L QD L+
Sbjct: 4168 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4221
Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
++ +L I +++ ++ + + EA+Q+Q+ E + +A ++K
Sbjct: 4222 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4281
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
EE S+ V+ L E + + L I R + L A L +++ A+ + +T
Sbjct: 4282 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4339
Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
E ++ + VG +++E+ L K L++ V Q E + S+ E
Sbjct: 4340 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4398
Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
LQ L+ L + + E + ++ + + L K + ED+ L+ E L + +
Sbjct: 4399 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4458
Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
LP + +E L +E A + + K + K +Q+L RC ++ + + ++
Sbjct: 4459 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4514
Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
L EKW S+ E + EE W +E+ R ++ILD +
Sbjct: 4515 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4574
Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
++ E + + + E++ EL L Q + V + LL+++ + + +Q
Sbjct: 4575 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4634
Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
+ E +++ A+ ++ E K L ++ + + ++T++ + F
Sbjct: 4635 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4694
Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
K + A + + T + +++ + D+ + + EL Q+ L++
Sbjct: 4695 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4754
Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
L + L+ +Y + P E Q + L D + E+ K + S
Sbjct: 4755 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4814
Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
A++R E+ G + V+ +Q+ S E + L+ + E S V
Sbjct: 4815 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4874
Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
++E + G + D L Q+++ ++ E + ++LNKAT +
Sbjct: 4875 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4934
Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+ D + + + WI + + L H + AL K LL ++
Sbjct: 4935 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 4989
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
L+ TD+ + I + +V AL Q ME + + Q D V
Sbjct: 4990 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036
Score = 155 bits (392), Expect = 1e-36
Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)
Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
+L L+S+ ++L + ++ FS +++ Q Q+ +++ + +E Y +
Sbjct: 1037 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1096
Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
++++ N + D+ + QI + L E R++ Q+ K++ L
Sbjct: 1097 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1148
Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
KDD+ ++ +C++ + +S+ + LN +L++
Sbjct: 1149 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1196
Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
+ + + + V ++TQ + A+ KL E +++ + + + ++ + ++ DE+
Sbjct: 1197 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1254
Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
+ +ELQ D M + + +++ + K+ A + +E+ + ++
Sbjct: 1255 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1305
Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
+DN L+ L + K+ + +++ VE++ + + +E+
Sbjct: 1306 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1351
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
T L++ K ++ IE ++ + + E S V D + + +++SQ K
Sbjct: 1352 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1411
Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
+ I +++ Y TLM + D+ L+++++ L+ K
Sbjct: 1412 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1471
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
E+A +LQ S AE K + K+K + E+ ++ E L
Sbjct: 1472 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1521
Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
+ + L K + RN++++ + L S LL + L Q+++ + + D
Sbjct: 1522 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1573
Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
+ ++ V +E K+K+ LT E + + + + + K + ++L+
Sbjct: 1574 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1633
Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
++ + A + K + + QE + LI E EA++K + L+A Q
Sbjct: 1634 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1689
Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
+ +E+D ++T ++E T E++ QL+ K + + ++ N + E
Sbjct: 1690 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1739
Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
+Q E+ +E D N LL +V+ V NL + +K
Sbjct: 1740 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1799
Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
+++ + + Q Q E++++L++ +K+L E AL
Sbjct: 1800 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1854
Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
+ + L E+ D + L Q Q +E + D+I + KL K+F
Sbjct: 1855 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1912
Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
+ + + + D Y + N VLE + ++D +++ L
Sbjct: 1913 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1962
Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
H ++ +S + ++ +K + ++ + E + A + + +A TA + E + +
Sbjct: 1963 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 2021
Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
+++ +L E + LQ Q+++ + VL DA +L K + + ++ I
Sbjct: 2022 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2077
Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
VG E+ + + E+L+ T+ +QD L E L + + E+ L+ Q
Sbjct: 2078 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128
Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
LQ+++SKN +++ +++ E K + + + ++L L
Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188
Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
S ++E L ++E+ K V + E KL+ L TE D G + ++
Sbjct: 2189 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2245
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
+ E LE K E+ LK+ S + + A++L+ NL ++ E+ T
Sbjct: 2246 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2302
Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
KEA T+ CQ E ++ Q+L+ L I+ + VP
Sbjct: 2303 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2341
Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
Q ++ K L+ +K +E + E I+L N TT + +A
Sbjct: 2342 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2400
Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
+ +E+F KG + + M + Y ++ ++ AE+ +++
Sbjct: 2401 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2455
Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
+ +KA E+ +K++ K + A E + + + + +N+ K
Sbjct: 2456 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2514
Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
QE++ K+ + L+ W L E+DS+ Q++ + D Q E N + FQ
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2574
Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
Q +Q E S Q + + ++E++ E
Sbjct: 2575 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2634
Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+L+ P + SLR LS + A+ S Q +LL S+
Sbjct: 2635 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
L DL + + + NQ QK+ + + Q Q + +D+ A+ E
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2754
Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
+ +++ IL S + + E H++H + + ++ + ++ + Q
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2814
Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
P+ + +LE++ ++ + K + Q++ +++ I + +L
Sbjct: 2815 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2857
Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
L+ ++A +L ++ + KQ+ N+ KE L + K V L + +
Sbjct: 2858 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2917
Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
Q +E + +E E +A+ + ++++ N S+ + +++EV
Sbjct: 2918 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2977
Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
KS D E+ ++ + K+ +E S S +Q A ++ D+
Sbjct: 2978 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3035
Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
+Q + L Q + SL+ + + + D +++SD++G + +VE E
Sbjct: 3036 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3095
Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
+ + + + LE LQ N E + A+ + L++Q
Sbjct: 3096 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3155
Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
+A L ++E +A +TCK ++ D + + EALS + L +
Sbjct: 3156 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3215
Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
E+V+ L+E +S+ + +IL + +E EH+E+ PV + E E+I Q + K F
Sbjct: 3216 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3270
Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
Q++++ L+ +Q +++ I+ AK Q +HD D T + A A
Sbjct: 3271 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3330
Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
E D +S+LS W EL + K P L
Sbjct: 3331 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3382
Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
+L++ + ST + IL +++ + R+ + +T QLE +
Sbjct: 3383 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3442
Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
A E ++K+L +Q S +EE + + +D H
Sbjct: 3443 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3500
Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
L+ A+S G LK ++ E+ +++ D QV Q + RS+ L
Sbjct: 3501 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3548
Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
+ L + + + L + L + L + S+ + S + + +Q + ++ +
Sbjct: 3549 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3608
Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
V + G L L EV ++D L++ ++ARY +++ S V ++ + AL
Sbjct: 3609 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3663
Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
L E L K+ E L++ + K + A QAQ+ +N+K L
Sbjct: 3664 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3722
Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
V+ LL +++P W + K++ E + + + ++ QK EE D
Sbjct: 3723 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3767
Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
A++ + + + +S + ETE++L+ ++ S Q+++ + R
Sbjct: 3768 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3824
Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
+++ G +++ + S E + KL+ + +N + +L R Q+L+
Sbjct: 3825 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3884
Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
+ ++L WL +Q ++ +L + +T+R + + + E
Sbjct: 3885 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3937
Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
+ G QLL L + +++ + ++ + + L + + I
Sbjct: 3938 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 3997
Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
+++ + + + S+ + ++K + ++K ++M+ Q + + + Q ++
Sbjct: 3998 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055
Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
+ D+ +K + + L +M W +H ++ + L ++E +
Sbjct: 4056 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4110
Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
L ++ ++ ++ L+ P SV K Q+ + + L E + L S
Sbjct: 4111 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4167
Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
+ + IDEL S+ ++++L+ +MQ+ +Q ++D V+
Sbjct: 4168 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4227
Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
+ + + P+ LET++ Q+E L+ + EA + E+L L K
Sbjct: 4228 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4283
Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
S +++ W + + I ++ K + L + +A E A L E
Sbjct: 4284 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4343
Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
+ + G+ A + A + LQ+DV Q T EA + + L E+S
Sbjct: 4344 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4398
Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
L L L QR + + + + + L Q K F +E L+ + E +L
Sbjct: 4399 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4456
Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
L + KE + + A A+ + L ++ + P S + + N+
Sbjct: 4457 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4516
Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
+W ER ++L+ + L +F + +I L + E+ L V S P L+
Sbjct: 4517 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4573
Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
+++ E +V N+ +S+ Q ++L T T ++ ++ + + L RW+
Sbjct: 4574 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4631
Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
VQ + +R +D ++ + F + L +L ++ L S ++ +T+ H+
Sbjct: 4632 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4691
Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
K + + + T G L T L + +S+L+D W + + E
Sbjct: 4692 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749
Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
+ + + Q ++ L L ++ Q + P +H D+ LI K ++ L
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4808
Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
T +++ L+ +L +D +K Q++ L +WE +C ++ +E L
Sbjct: 4809 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4867
Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
F+ L WL + E VL + ++ +I++ K+ M+++ +
Sbjct: 4868 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4926
Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
MGD ++ + I + I R++ + ++L A + + + L
Sbjct: 4927 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4986
Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
WL E+ L+ K V+ + +E++ +AE Q ++ + V+ V
Sbjct: 4987 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5044
Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
D + ++T+ ++ L +W+ + +++E
Sbjct: 5045 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5104
Query: 6127 RRMKIEE 6133
RR K+ +
Sbjct: 5105 RRRKLND 5111
Score = 146 bits (369), Expect = 6e-34
Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)
Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
P+ +AM P++ F++ P +E++ +E+ Y + E + + ++ H+L
Sbjct: 956 PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 1011
Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
N RI S+ +S + Q L++LQ + +E ++ S +LE VN
Sbjct: 1012 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1071
Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
K+ + ++ LK ERE Q + R+E+ E L ++ P+E+
Sbjct: 1072 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1127
Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
L H+ F + + +++ + L ++D + I N+ EE +
Sbjct: 1128 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1172
Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
L + N++L+ Q M+ D LK + L + + A+ + T L +
Sbjct: 1173 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1229
Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
+A +N + T+K E+ H ++D KAK + K K D+ F
Sbjct: 1230 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1289
Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
+ D E N+ +L + G G ++ + L+ I + + IQ+ Q
Sbjct: 1290 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1349
Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
+ SK T+ +++K L+ ++ + +E +++ ++ + ++ KD +T+
Sbjct: 1350 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1400
Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
+ ++ K+ V Q L +++++ + ++ T L+ + Q
Sbjct: 1401 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1450
Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
++LK+ E + ++EE EH+E ++ + N+ L + +PPF K+
Sbjct: 1451 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1504
Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
+E+ E L AL I + K KM T+E+R L++++
Sbjct: 1505 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1547
Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
+ + E FS + ++Q S ++ +E +++ I + + + L
Sbjct: 1548 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1607
Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
G + T EL+ + + K G ++L + + +++ E KL + +
Sbjct: 1608 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1667
Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
+++QK L E +I C L + + KK+ + V +++ +L + K
Sbjct: 1668 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1723
Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
N DW SN+ + + F+ + K ++ ++ + + L
Sbjct: 1724 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1783
Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
T E N + ++V + ++ + + +++ GQ E+ E + Q KE
Sbjct: 1784 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1842
Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
L+ SLQ+ L D D+ WL E++ + +E +
Sbjct: 1843 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1902
Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
L R++ E V L+ + + +C
Sbjct: 1903 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1962
Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
DR+++L + + + K L + Q + D +A D
Sbjct: 1963 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2022
Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
+ ++++E+ + + E+++K E++L DAR + + + +Q
Sbjct: 2023 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2071
Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
KTL DI ++++ L+ + EKL + + L ++ L ML +E K++
Sbjct: 2072 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128
Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
L A I K + QD+ +S N + E K + +P
Sbjct: 2129 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2174
Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
SL +++D +H + +L T + +N S++ +F + +
Sbjct: 2175 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2234
Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
V E Q +QE + L+ + +L K + + + ++ + +L
Sbjct: 2235 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2294
Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
K K++E+ + K+ + C ++KS +S K+ +P + D+ +S
Sbjct: 2295 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2354
Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
+++ +KL+E W EI K A+ S LN + +
Sbjct: 2355 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2411
Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
NTE+ ++ + ++ + +L +L+++ E KL +A++ + ++
Sbjct: 2412 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2471
Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
+ +NKT T + +A+ T +++NK + E+ +
Sbjct: 2472 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2508
Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
K + + LK D +T L + + K L + KW+ L+ D +KL
Sbjct: 2509 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2564
Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
ES + Q ++ + Q +VE + +++ + L Q+Q +Q+ L+
Sbjct: 2565 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2618
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
R Q T G +L E + +++ + + ++W++L
Sbjct: 2619 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2663
Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
+ + I + +++ +++L + +L +L+ S+ + PD + Q+ +
Sbjct: 2664 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2723
Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
I ++ + ++L E++ V Y ++L+ LE + ++ + K+
Sbjct: 2724 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2781
Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
Q L+ F + R FQ + + E + K H ++ LE+
Sbjct: 2782 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2829
Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
K+ ++ ++ +H+ E T N+ + E+ L+ QL +K + + ++
Sbjct: 2830 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2889
Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
N+++ ++ ++ E+ L D Q N E+ + +G ++
Sbjct: 2890 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2949
Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
+ + + L +L V ++ K ++D + Q+ K+ LE ++
Sbjct: 2950 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 3009
Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
F+E + K Q +K +D+ ++ + ++++ + Q L +++ AK L
Sbjct: 3010 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3068
Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
+++ + +++K D +LQ++ A+E+ L + + L K + Q+ +
Sbjct: 3069 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3123
Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
+ +L + + + +Q +K+ +AF +++ A M S K
Sbjct: 3124 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3183
Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
+ D+ R+ E L Q N +D L + Y L + + +A
Sbjct: 3184 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3243
Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
E S P ++ + L M + ++EE+E QD+ G+I S
Sbjct: 3244 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3299
Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
Q +L N+ K K A + E + ++ + + LS M E V
Sbjct: 3300 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3359
Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
Q S ++ ++++ K L L K + +++ + D + +LK
Sbjct: 3360 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3417
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
+S L +W +LL A+ E + + E +E L +++ L E T+
Sbjct: 3418 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3477
Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
+ E++++ L D + + +++ + + + + + + E V++ F ++
Sbjct: 3478 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3532
Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
+ ++ +K EL+Q + F ++ + L N+ + ++ QD+ +
Sbjct: 3533 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3587
Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
+Q EL+ + + L +N+ + L + E I+ ++E + +DI
Sbjct: 3588 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3646
Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
K+S +V K+ + + R++ EE+ L VE L K + +AQ K
Sbjct: 3647 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3706
Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
++ E + L+ L+ ++E P +A+E ++ ++ ++Y+ VS + ++
Sbjct: 3707 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3766
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
+ A ++ +++ + +WI T L + D L ++ Q+ ++ + L
Sbjct: 3767 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3822
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
H + D+L +S ++ + + Q + + L ++ + D + I SE
Sbjct: 3823 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3871
Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
+ + +S++ L E EEH + E+I
Sbjct: 3872 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3931
Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
E +I M KT +++ P G + + L IK E+V +++ L
Sbjct: 3932 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3983
Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
I Q+ ++ ++I+ + + SLE + ++ + P + E+E++++QI
Sbjct: 3984 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4029
Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
+++ VD++ + L++ LKQ E
Sbjct: 4030 ENKNVSVDME-KLQPLYETLKQRGE 4053
Score = 90.9 bits (224), Expect = 4e-17
Identities = 379/2122 (17%), Positives = 783/2122 (36%), Gaps = 342/2122 (16%)
Query: 4938 RLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQ-----DLDTIRSNINNFF 4992
R L LL N +++ ++ Q LN+ E + + + DL ++ S++ N
Sbjct: 614 RKPLLKSSLLDQNLTEEEIN--MKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHK 671
Query: 4993 EFSKEVDE-KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
+ ++E +SSLK A IS LK T L + E ++ L+ + + L
Sbjct: 672 NVHRAIEEFESSLKEAKISEIQMTAPLK----LTYAEKLHRLESQYAKLLNTSRNQERHL 727
Query: 5052 HQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYK 5111
L SR A E+I W+N E + D ++ ++ K H E E+D K
Sbjct: 728 DTLH--NFVSR-ATNELI-WLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQK 780
Query: 5112 QWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQ---L 5168
+ + V + QL + R + M QW + + QH+++
Sbjct: 781 EENIKSVQEIAEQL----LLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 836
Query: 5169 LESITESENKIQILNNWLEAQE-----ERLKTLQKPESVISV----QKLLLDCQDIENQL 5219
E +++ L N +A + +R ++ K E ++ ++ LL + L
Sbjct: 837 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 896
Query: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEW 5279
K+K + +LK + PL + +++ + + ++ + S +W
Sbjct: 897 MGKAKTIIQLKP-----RNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKW 951
Query: 5280 KIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAE---SSEGSWEK 5336
K+ +E + ++ F + + V L+ + Q +N+ +L E+ S SW
Sbjct: 952 KVISPTGNEAMVPSVCFTVPPPNKEAVDLA-NRIEQQYQNVLTLWHESHINMKSVVSWHY 1010
Query: 5337 LQEVIGKL--------KGLCPSVAEIIEEKCQNTHKRWTQVNQAI----ADQLQKAQSLL 5384
L I ++ K + P + + Q+ + + + +Q + + + +
Sbjct: 1011 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1070
Query: 5385 QLWKAYSNAHGEAAARLKQQEAKFQ----QLANISMSGNN-----LAEILPPALQD---- 5431
+ K Y ++A R +Q+E+ + ++ NI + N + +I P +D
Sbjct: 1071 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1130
Query: 5432 --------------IKELQHDV----QKTKEAFLQNSS-------------VLDRLPQP- 5459
++ L+ D+ K +E F Q ++ VL + Q
Sbjct: 1131 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1190
Query: 5460 AESSTHM----LLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMH 5515
+ SST++ + L + Q A L K+ K E E V++ + + +LK
Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1250
Query: 5516 EEENLDRLHQQEKE-NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQ 5574
+E H E E ++ + T + D++ D + + +
Sbjct: 1251 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF-----------DWHKEKADQLVER 1299
Query: 5575 WIRATATALERCSELQGIGLNEKFL----YCCEKWIQLLEKIEEALKVDVANSLPELLEQ 5630
W R +L+GIG + K+ + + WIQ +E + ++ + + L Q
Sbjct: 1300 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1359
Query: 5631 QKTYKMLEAEVSINQTIADS---YVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQG 5687
KML +E+ + Q+ D Y Q + E++ + + D Q +
Sbjct: 1360 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT-----YRAMVDSQQKSPVK 1414
Query: 5688 VRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL--SAVKGQERFSLYQTRSLIHELK 5745
R+ + D +++++ D T L +T S + +E + H K
Sbjct: 1415 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1474
Query: 5746 NKEIHFQRRRTTCALTLEAGEKL---------LLTTDLKTK-ESVGRRISQLQ------- 5788
KE+ Q+ + + TL+ EK + + ++ TK E + + +Q
Sbjct: 1475 AKEL--QKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1532
Query: 5789 -----DSWKDMEPQL-----------AEMIKQFQSTVETWD-QCEKKI-----KELKSRL 5826
+ ++E Q+ +E +KQ Q + + D + E+KI +E K +L
Sbjct: 1533 DKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL 1592
Query: 5827 QV---LKAQSEDPL-------------PELHEDLHNEKELIKELEQSLASWTQNLKELQT 5870
Q L Q+E+ L EL + ++EL K+++ S + + +K +
Sbjct: 1593 QGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN 1652
Query: 5871 MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNK--- 5927
+ + ED ++++++ + E L L+ K+E+ D++ T + E K
Sbjct: 1653 FLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL-DKVVTTAIKEETEKVAA 1711
Query: 5928 ------------ELCAWLVQMENKVLQTADISIEEMIEK--------------------- 5954
L WL ++ K + A +++IE+
Sbjct: 1712 VKQLEESKTKIENLLDWLSNVD-KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN 1770
Query: 5955 ---LQKDCMEEINLFSENKLQ---------------------LKQMGDQLIKASNKSRAA 5990
L+ D ++ EN Q Q L++ + +
Sbjct: 1771 GNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1830
Query: 5991 EIDDKLNK-INDRWQHLFDVIGSRVKKLKETFAFIQQLDK---NMSNLRTWLARIESELS 6046
E +KL K + + H + KK+K T + ++L+K + + WL + E EL
Sbjct: 1831 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1890
Query: 6047 KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANET--ECD 6104
+ D + +L Q+ D+ H + + + +L + +C+ + D
Sbjct: 1891 N-LEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1949
Query: 6105 SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED-------WLKSAER 6157
+ T R + R+ + K + +D Y +ED L++ E
Sbjct: 1950 T-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA 2008
Query: 6158 TAACPNSSEVLYT--SAKEELKRFEAFQRQIHERLTQLELINKQYRRL--ARENRTDTAS 6213
TA+ S + + + +L+ +A Q QI + +E + K L AR + +
Sbjct: 2009 TASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2068
Query: 6214 RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWL--TEMDLQLTNV 6271
+++ + + R+++L + V +L+ + + + +L W+ E L+
Sbjct: 2069 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128
Query: 6272 EHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEEL-- 6329
+ + D + + +Q+I + I+ + ++ ++ ++P A ++ ++++L
Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188
Query: 6330 ------HRY------CQEVFGRVSRFHRRLTSCTPGLEDEKEA-SENETDMEDPREIQTD 6376
H++ +E+ +V F LE + +A +E + +D E+
Sbjct: 2189 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2248
Query: 6377 SWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEE 6436
E E + H + G + + L + T ++ ED
Sbjct: 2249 MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-----LVLEKTNNLSKKFKEMEDTI 2303
Query: 6437 GPYYSALSDVE--------IPENPEAYLKMTTKTLKASS--------GKSISDGHSWHVP 6480
A++ + + ++ ++++K TTK + GKS+ D
Sbjct: 2304 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2363
Query: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNG----- 6535
S PE G ++ + A +TP K K G VLNG
Sbjct: 2364 WSLKTPEIQKVNNSGI-SLCNLISAVTTPAK----------AIAAVKSGGAVLNGEGTAT 2412
Query: 6536 NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIKQNLQQLNSDISAIT 6587
N ++ + GL I + + +E + + EL+ KL LQ+ + SA+
Sbjct: 2413 NTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS---KLQKAQEESSAMM 2469
Query: 6588 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQ-- 6645
WL+K + P+D + ++ +V++ + V + E L+
Sbjct: 2470 QWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN 2529
Query: 6646 TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
++PE+ + L ++ W+ + L +S F + L WL
Sbjct: 2530 PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLV---E 2586
Query: 6706 RRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIE 6764
+ V P DP L R+++ L +E R+PQ + L +L + + +
Sbjct: 2587 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2646
Query: 6765 --AEEKVHVIEKKLKQLREQVS 6784
+E++ + +K L Q+S
Sbjct: 2647 GIVKEQLAAVTQKWDSLTGQLS 2668
Score = 88.6 bits (218), Expect = 2e-16
Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)
Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
++LS G+ +QE++ + L L+ I ++ + I + + +I
Sbjct: 3948 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4007
Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
+ P++ A + K + ++K+ YE K+ +EM A S KD
Sbjct: 4008 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4067
Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
K V + V +WEN LV E + V+EL +++ + S++ T+ ++ + L
Sbjct: 4068 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4127
Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
+ + +K++ E ++EE + E +D + + L + ++P +K
Sbjct: 4128 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4184
Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
+ + W +N+ +D + L A+ + + + +W + A K+ D E
Sbjct: 4185 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4244
Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
+K++++ +Q SE ++ E++ L +E+ L+ ES L +++ + L
Sbjct: 4245 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4304
Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
+ H L G + + + LD+ + TE LL P ++E +
Sbjct: 4305 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4364
Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
+LQ K L+E+ G L +L L +++++V + +K L
Sbjct: 4365 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4424
Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
+K + + ++ W ++ + +L K ET K EQ + E +
Sbjct: 4425 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4482
Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
K + + + PK+ + + + + E +E+ R +LE++L +
Sbjct: 4483 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4542
Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
+ ++ WLT E+ P ++ ++F + REQ + +
Sbjct: 4543 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4602
Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
LK F++++++++ L+ R++ ++++L E + F++ ++
Sbjct: 4603 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4660
Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
W++E ++SL + ++ + KIK + E + ++ + L
Sbjct: 4661 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714
Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
+KT L+++ ++WD + + E+ LL ++ + + L L
Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4774
Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
++ + + + + +K F K+ TS ++ LK L+E ++ + S+
Sbjct: 4775 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4834
Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
+ E+ E++ L+ +R+ + + V L L +
Sbjct: 4835 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4894
Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
P D+ A+ + + +E +L + L K +LA+ T II+
Sbjct: 4895 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4954
Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
+ + K + RLAS AKQE +E L + ++ + K K +P ++ +
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5014
Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
+ +E T++ V+K+ + ++
Sbjct: 5015 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5041
Score = 58.2 bits (139), Expect = 3e-07
Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)
Query: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4736 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4793
Query: 6613 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6672
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4794 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4853
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6731
S + L +L Q ++FH + LL WLA A+ R + D + R L++ +E M
Sbjct: 4854 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4912
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6779
K+L E++ +++ + +++L H + + + +I + +++
Sbjct: 4913 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4958
Score = 53.5 bits (127), Expect = 7e-06
Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)
Query: 6571 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6627
K+++ +Q Q + A+ W+ +L M+ +D++ ++ +++ L++
Sbjct: 4204 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4261
Query: 6628 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6685
+ + +N ++ L+ TE + +Q L +L L+W++ + + + + L +L+
Sbjct: 4262 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4321
Query: 6686 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6743
F LL WL + QK DPKA L + L+ +++ Q V
Sbjct: 4322 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4377
Query: 6744 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6797
+ + + N L+ GE+ + K+ V+ ++ + + E+ Q L G A
Sbjct: 4378 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4431
Score = 45.4 bits (106), Expect = 0.002
Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)
Query: 585 LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
L W T+ E L + + K EI+ L L H + +N+AGN L+E S
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4391
Query: 640 NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
S++ +L LN+RW+ ++ KT+ +KQ L +
Sbjct: 4392 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4433
Query: 700 FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
F ++ E+ Q + E+H ++ G + AK E+L +E+ A EAK
Sbjct: 4434 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4482
Query: 759 QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
EE+ K L+ KG M +E + DI N+ +E ++ V + K+
Sbjct: 4483 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4527
Query: 818 EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
E K K++ L++ ++ S ++ +++ +A+Q L P +
Sbjct: 4528 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570
Query: 878 -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
I +HK + S+ + + + K LK + + ++ V ++WE
Sbjct: 4571 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4630
Query: 929 LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
+ VQ+L +E+G+ D+ K KQ ++ KL+ K L E E
Sbjct: 4631 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4680
Query: 986 EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
+ QL H E + L + + R LK+
Sbjct: 4681 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4716
Score = 43.9 bits (102), Expect = 0.006
Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)
Query: 6564 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6623
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2782 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2836
Query: 6624 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6681
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2837 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2895
Query: 6682 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6741
SL + + + + L W+ +N ++ DP +L L+KE+ +
Sbjct: 2896 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2952
Query: 6742 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6801
V++L +NSLL + + +E +I+ K+ + EQ+ L +N
Sbjct: 2953 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 3008
Query: 6802 SFDEV 6806
F EV
Sbjct: 3009 EFQEV 3013
Score = 41.6 bits (96), Expect = 0.028
Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
W+ ++ + ++ + K++ L Q + + WL TE +L KP D + IE
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4357
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
+ + + + +++ V +VN + + +++ + E++ LQ++L L+ W+
Sbjct: 4358 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4417
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ + L +L Q + FH ++L WL + H+ K L E +E + +
Sbjct: 4418 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4471
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6778
E+ + +E SL+ KG +D +EK +E KL +
Sbjct: 4472 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4528
Query: 6779 LREQVSQDL 6787
+ ++ + L
Sbjct: 4529 RKTKLEEAL 4537
Score = 40.0 bits (92), Expect = 0.080
Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 8/153 (5%)
Query: 6557 RWEMIQAQELHNKLKIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 6613
RW+ + + K ++ L+Q + +I + WL TE L K + + +
Sbjct: 4409 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4468
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGA 6671
L V E+ AF+ + S+ ++ L P+S E + + L WE+ +
Sbjct: 4469 LNVH--MEVCAAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETK 4525
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6704
++ + L ++L +FH Q+ + WL A+
Sbjct: 4526 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4558
Score = 38.9 bits (89), Expect = 0.18
Identities = 45/216 (20%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 6577 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6634
QQ + A +W+ +TE +L L + D +L+V++ EIL+ D LV
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3833
Query: 6635 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6694
S K E ++ +L ++ ++ L ++ F + +
Sbjct: 3834 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3890
Query: 6695 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6754
L WL ++ + + P + L + + E QL + + E +P +D + + LL
Sbjct: 3891 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3948
Query: 6755 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL 6790
GE +EK + Q++E V + +AL
Sbjct: 3949 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVAL 3983
Score = 37.0 bits (84), Expect = 0.68
Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)
Query: 6558 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6610
W + ++ H++ ++ Q N + D + WL + +L L + ++ Q
Sbjct: 3533 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3592
Query: 6611 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6670
+ ELRV + +L+ + +AL+ + + QT E +Q +L + ++
Sbjct: 3593 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3648
Query: 6671 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6730
L Q+L + H + L WL + K + + + R +
Sbjct: 3649 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3706
Query: 6731 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6783
+L+KE + +D L E+S++LL +G + E E+ ++ + Q E++
Sbjct: 3707 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3766
Query: 6784 SQDLMALQ 6791
++ Q
Sbjct: 3767 DAAILRSQ 3774
Score = 36.2 bits (82), Expect = 1.2
Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)
Query: 310 KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
K+++++L K +++ Y ++ ME N + + L ++ + D + ++L+
Sbjct: 4247 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4300
Query: 370 WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
WD L+ +I + KL AL L + AWL E L+ E D +A+ +
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4359
Query: 423 ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
+Q + +S ++ N L+ +E ++L NKLE + +R N+LE
Sbjct: 4360 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4415
Query: 476 K 476
K
Sbjct: 4416 K 4416
Score = 33.5 bits (75), Expect = 7.5
Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)
Query: 6647 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6706
+S + L+ L ++ W+ V L+++L+ C F ++LL W+ +
Sbjct: 3298 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3355
Query: 6707 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6766
A+ P A+ + + +E L++ L +R+ V++++ + D ++
Sbjct: 3356 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3415
Query: 6767 EKVHVIEKKLKQLREQVSQDLMALQG 6792
+++ +++ + + L + L+G
Sbjct: 3416 KQLSLLDSRWEALLNKAETRNRQLEG 3441
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 234 bits (596), Expect = 3e-60
Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)
Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
+N I + + S K LPG +Q S++Q E +QES + +LE++
Sbjct: 1023 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1082
Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
+ K E+ S + N + ++N ED R + +++ PLE D +
Sbjct: 1083 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1140
Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
+ ++ E EKL +LE K + + E ++ + +VL N+
Sbjct: 1141 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1200
Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
S+ ++D L + LK N ++ +++ ++ L E A++ DK +++
Sbjct: 1201 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1249
Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
+ +K++ + +++++ L+ + + +M K E + QL
Sbjct: 1250 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1308
Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
W+ V QI + + + + +DT L Q ++ + +E S
Sbjct: 1309 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1364
Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
L T L K S E++MK+ ++ +K E +K +
Sbjct: 1365 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1417
Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
+Q K R +M+ + +L L + + K D + ++ +S
Sbjct: 1418 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1474
Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
L EE K+ V + S+++ TL+D + K S+++ K E+ S
Sbjct: 1475 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1534
Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
I+ F +QES L+ + +++ + T ++K +
Sbjct: 1535 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1594
Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
Q+E +E GI L + N + E + D +LK + + +Q+ +Q +
Sbjct: 1595 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1652
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
+ +K F L+E + + Q ++ L+ Q++N+ +K E NLK D
Sbjct: 1653 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1706
Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
++ TAIK + Q+ + K + + L+W S +D+ + K K++ I+Q
Sbjct: 1707 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1761
Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
T F+E GK AI + + ++ D + + N L+Q+ +K K
Sbjct: 1762 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1810
Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
++II ++++ + + ++L K L+ EE +KL K ++ + + E + E ++
Sbjct: 1811 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1867
Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
K + Q++LE + + LQQ L NLE I + + ++F E V
Sbjct: 1868 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1927
Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
+ ++ +T + + + S+ +V+ KL D L + +
Sbjct: 1928 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1987
Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
+ N L D + Y++A + + + EA + P VD N + LE Q
Sbjct: 1988 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2047
Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
++ S ++ L + ++ S AK +Q TL ++V + + ++ + + +
Sbjct: 2048 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2107
Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
L + +++ + +E+ L + +PL+ + + ++ L ++ +
Sbjct: 2108 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2166
Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
+ + + ++ + L + L ++ KE EELK + +
Sbjct: 2167 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2223
Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
+ +NL E+L +TK A TE ELS+ + + ++ E+ + +
Sbjct: 2224 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2275
Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
+L +LL + S +P V ++ ++ ++ ++ +++ KE V + ++
Sbjct: 2276 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2328
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
+F + +LK++ ++TT + E + E+ + + +K L I +
Sbjct: 2329 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2388
Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
I + + V PA+ + V+ L + +E +N+ L S S Y
Sbjct: 2389 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2448
Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
++ KI E+N L ++K ++ S ++ Q++ K W
Sbjct: 2449 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2508
Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
EL +K+ EL ++ +++E++P +A W L ++Q+++Q
Sbjct: 2509 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568
Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
R +L +++ + ++ + + W+ +++ P D L+ VQ+ L+
Sbjct: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2627
Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
+ + + + LS E L ++E VT + L D
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687
Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
+ ++ +S+ + +S + L +K + H LE + MK+ I
Sbjct: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2740
Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
Q K + V Q + L + E + E + L+ ++K + +++ EN Q
Sbjct: 2741 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2794
Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
L + A + MS D L + E + L+ E L+ D K + L
Sbjct: 2795 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2853
Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
H+ ++ + L E + + K N + E +++ES K+
Sbjct: 2854 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2913
Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
E+ E W + K ++EE + + +NS+A++ SL
Sbjct: 2914 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2956
Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E + N T E D +D L +V+ TE LH+ K +
Sbjct: 2957 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 3012
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
+ Q+ E Q E+ + L+ K+Q + D+
Sbjct: 3013 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3044
Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
+Q + L+T + +L+ K Q+ L ++ ++D ++ ++S+ + + L
Sbjct: 3045 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3096
Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
++E+I E S+Q D ++ LE K F I ++M+ Q+ + D++
Sbjct: 3097 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3150
Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
++P G++ + Q + + +K +E +++N
Sbjct: 3151 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3187
Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
+ M T+ +L LE L ++ + L + EE K+L E + L +
Sbjct: 3188 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3246
Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
+L+ + E + ET+ +L + ++ L + + W G+
Sbjct: 3247 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3303
Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
+T L D++ + R+ L+ L + +Q+ ++ L ++
Sbjct: 3304 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3363
Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
++ + Q + V Q+Q+ L++ +S V ++ EGE++ +V
Sbjct: 3364 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
L+ + LDS W L R +L V Q L+ + E + +++L +
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
+Q AL+ I NH + V+ ++ S++ ++Q++ F
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3541
Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
QV ++I +EKS LQ L + F E+ L L + L +S+ + + E L
Sbjct: 3542 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3600
Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
++ S + ++ +I + + Q L G +L+ + E ++ ++ ++ ++ + K
Sbjct: 3601 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3660
Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
L+ L+ + ++L WL+ + L ++ Q L + +R
Sbjct: 3661 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3717
Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
E KE +L ++ + + LL L L +A+ +++ ++ + E
Sbjct: 3718 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3775
Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
++ + +A +SW+ E + + + + LQ K F ME +
Sbjct: 3776 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3833
Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
+K I D V ++ C E K+ + + + L E Q R ++
Sbjct: 3834 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3893
Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
N+ + E+L +TE+++ I + L A +TL Q+ E +++L+ + + +
Sbjct: 3894 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3949
Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
++ L EL ++ Y+ ++ + ED R +DE + + +++
Sbjct: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4009
Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
Q+ S++ +++ + + EV + + + +K V + +E L+ E L+ +E
Sbjct: 4010 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4065
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
+ G +K A+ +++K W ++ + ++ K +++L
Sbjct: 4066 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4113
Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
+ + H +K + + L + + + + + A + I+E +Q+ +
Sbjct: 4114 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4172
Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
+ S L +P + L SL +A LE+ +
Sbjct: 4173 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4232
Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
F++V L+ G LE++K I ++ +QQ+ E LNH L
Sbjct: 4233 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4288
Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
++ + E S K + D L + W + R +L+G L +F + +
Sbjct: 4289 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341
Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
+ + L E L P+ +E + + +L+ +V +Q+ ++ L+++
Sbjct: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4401
Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
+ E + L RWQN ++ QRK +DG +RQ + F +E+L ++LTDT
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
L A K L E N + F+ + T ++ G+++L +
Sbjct: 4462 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4516
Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
++ + I+ L++ W+ +E +L E + + + E + + I L Q L S
Sbjct: 4517 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4576
Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
L + + + + + K + S + + EL L +DV+++K +
Sbjct: 4577 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4634
Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
+ +WE + R+ R + ++D F+E +L WL + E + +I+ +
Sbjct: 4635 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4694
Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
K Q K+ + + + G L K S ++DD L+++ D+W +
Sbjct: 4695 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4754
Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
R KL+E F Q + L WL R+E +L+ +PV D+ + +
Sbjct: 4755 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4811
Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
+ Q+++ + ++ V+++ L+ S + ++ + L RW +CA+S+
Sbjct: 4812 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4866
Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
++ ++E R ++F +WL AE+T P+ + L T + + + F
Sbjct: 4867 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4922
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+++ E+ +L + D+ + +K + R++ + +RL
Sbjct: 4923 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4982
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
+ E++L WL + LT+ + ++++ L F +E+T
Sbjct: 4983 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5042
Query: 6299 KIDQL 6303
+D++
Sbjct: 5043 DVDKV 5047
Score = 197 bits (500), Expect = 4e-49
Identities = 113/266 (42%), Positives = 148/266 (55%), Gaps = 35/266 (13%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT WIN L + ++DL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 72 ERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 129
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +L+ R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 130 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 180
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S MSA++ LLLW Q+ Y + +F
Sbjct: 181 -------DIHVTGESE----------------DMSAKERLLLWTQQATEGYAGIRCENFT 217
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
+ WR+G F AIIH RPDLIDM +V +SN NL AF +AE ++ + RLL+PEDVDV
Sbjct: 218 TCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPEDVDVS 276
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE 293
PDEKS++TYV+ P GE
Sbjct: 277 SPDEKSVITYVSSLYDAFPKVPEGGE 302
Score = 193 bits (490), Expect = 6e-48
Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)
Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
N EE N FV L+ D +Q ++ + + ++ ++ +A+E+F +SL+
Sbjct: 637 NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 696
Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
AK+ S+ Q+ LT K +H ++ + K+L+ S ++ ER
Sbjct: 697 EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 736
Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
DT + A + I L+E V +++E N + + EL++ NI+
Sbjct: 737 HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 796
Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
VQ ++ L++ + +R + +L + ++H++E F D +E
Sbjct: 797 SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 856
Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
T C + + + LV E +E+ +L+ N T+I
Sbjct: 857 ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 915
Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
Q S L+ S K R EI I K++ N H K +
Sbjct: 916 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 972
Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
+ F PP KEA +D+ + E Y+N+ L LW + N+K+V+ W
Sbjct: 973 MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 1020
Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
+ + E DR R + E + ++ +Q + E E QV S
Sbjct: 1021 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1072
Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
+ ++E V C + ++L ++ + ES+ L S+ I
Sbjct: 1073 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1117
Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
+LE + ++++Q + + L + +T E +LKK+ E + D T + ++ FS+
Sbjct: 1118 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1176
Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
+ + + N+ + + S T K+K V+ V
Sbjct: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1217
Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
LK+ + + L K + +L ++ + +E + S + E+++ Q L+D+
Sbjct: 1218 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1275
Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
L+K +E +K +E + + + E++++V Q++N L++ G + +
Sbjct: 1276 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1334
Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
+ +D + +T R++ E + E K L T+ L ++ E+K+S M
Sbjct: 1335 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1388
Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
E + E+ +K+ L A +++ + ++ S A L+ + D+
Sbjct: 1389 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1445
Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
++ + L + Y L +EK L E +K +++ ++L+ + LK ++
Sbjct: 1446 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1505
Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
AG + ++ K+ L +A L L G+ + + +N + L+
Sbjct: 1506 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1563
Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
+ L L+QLQ+S + D V +E+ + DL T +N +E
Sbjct: 1564 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1623
Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
D V+ + K ++LQ+ G+ + + + K+ + G+K+ ++D
Sbjct: 1624 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1676
Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
K+L +E +L AK + C LK+++S ++ +K T+ ++E T++
Sbjct: 1677 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1719
Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
AAV++LEE DW N D E A +K + Q +S EDE
Sbjct: 1720 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1779
Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
N L+ ++D + Q E + + Y +++A+ I Q + T++ ++L
Sbjct: 1780 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1834
Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
G S + + L + + LK + E+ LA E MK + +E L+
Sbjct: 1835 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1884
Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
D + L + ++ + ++E D + L K E++ +H +T ++
Sbjct: 1885 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1944
Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
LE+ + +V+ +++Q+K + + N + + L + QH
Sbjct: 1945 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 2004
Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
L L++ E A + D LQ L+GQ Q + K+
Sbjct: 2005 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2064
Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
K +++ ++++ ++E L E ++ + +++ + E +
Sbjct: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
W N+ L +PL + I K + I RQ S+ ++ E+VK + +
Sbjct: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
S L ++DL ++ K + ++E +L+ + F + + E++T +
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2243
Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
V+ + +E H LE L+EI S G+ + + + E+
Sbjct: 2244 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2300
Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
N + F +ED +K K Q + V+ + ++ +K +Q
Sbjct: 2301 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2360
Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
E+ +Q L E+ N G+ + NL +T I V V +
Sbjct: 2361 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2418
Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
G N + + + T + ++ L++KI +L+T + K Q +
Sbjct: 2419 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2475
Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
A+ ++KM + K A + E + L Q + K + L D++ +
Sbjct: 2476 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2535
Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
L EN ++ + K++L E D ++ L + ++ K + N + +T
Sbjct: 2536 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2589
Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
L Q ++ +L +L ++++ + ++ + ++ + +TA I +
Sbjct: 2590 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2649
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
E+ S V+ +L L + R + ++ A T+Y+ + + ++ L
Sbjct: 2650 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2709
Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
+ ++ + D N + LE + ++E++ I Q L E L A +
Sbjct: 2710 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2761
Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
+ +Y EL + + ++FK E +AE ++++ + +++M D + ++T
Sbjct: 2762 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2818
Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
+ S P+S + + LE L + SK L + ++ + + + LL+ + +E
Sbjct: 2819 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2876
Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
+ L L + W+ K+ +E W C+ +E K
Sbjct: 2877 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2936
Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
F + E E I L +LQ+E+ + + + + T+E L+
Sbjct: 2937 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2996
Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
+ E + ++ L + Q+ + Q V + S A E + + S +
Sbjct: 2997 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3056
Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
+LQ QK+ + ++ ++ ++++ + + T+ + Q+H S+Q +E
Sbjct: 3057 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116
Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
S L+ +G F+N + ++ +++E + A + E +K E I + E
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3176
Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
L +S A M EE + L ++E + +Q +K +++AQ ++++
Sbjct: 3177 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236
Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
L+ ++SKL E +Q E + Q M+ I P Q QQ
Sbjct: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
++++ R +QL +A + + D L+
Sbjct: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
S +W+ +T L+AN A++ ++ +Q L+D + + + I + E +
Sbjct: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3413
Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
+ E + + +++LS ++ AL K Q++ ++ ++ + + ++
Sbjct: 3414 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3473
Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
I+ L++ E EE + + + ++I K + + VS L++ +
Sbjct: 3474 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3533
Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
V + + ++ + ++ELL+ + + E+ L LN + S +
Sbjct: 3534 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3593
Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
+ L + Q E+ +++ IL Q + L++ LK T + ++ + E + +
Sbjct: 3594 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3652
Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
R +T VA+ +L RR ++L VE E+ + G+E +A
Sbjct: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
+ P+ K++K + + SS + +E K+ DN ++++ +
Sbjct: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E+ LR Q ++ ++DA+ EK +
Sbjct: 3773 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3809
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
++ L Q + ++ +Q+ +++ + ++ ++ ++ C ++
Sbjct: 3810 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3856
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
E +++ KL V N + + + E++ + + L ++E L P L+E
Sbjct: 3857 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3910
Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
+SI+++ P + RQ+ + +Q+ EL E K I K PQ + +
Sbjct: 3911 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3965
Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
+ QE +A S + DV D +S Q DK + L + +L P
Sbjct: 3966 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4025
Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
+ ++ Q+S N + + Y T ++ K +
Sbjct: 4026 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4085
Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
L+ + N+ T E ++ L +K + L +T+ + + LE P +
Sbjct: 4086 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4144
Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
QQ ET+ E+ L L + +L+ A P + ++ + D L
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4202
Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
+ A R L+ + YQ+ ++ ++ + + S + + L + Q
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4262
Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
+ K++AY ++E AE + K+ +E ++ + + + +L+ + DS+
Sbjct: 4263 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4318
Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
+ R +L + Q Q AL + + L + ++K G K + ++A ++
Sbjct: 4319 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4378
Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
N + Q V A LI++ SA S LQN+ ++ V EK+ Q +
Sbjct: 4379 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4434
Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
L L++ + F L++ L L+++ P L E +E+L + + ++
Sbjct: 4435 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4490
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
K + +G+Q++A CP+ ++ I L+E+W S+ K++ +L+ L
Sbjct: 4491 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4548
Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
+ ++ WL ++ TLN SL LDT+ I+ F+ EV +S
Sbjct: 4549 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4601
Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
+ +I + HLK + D ++ L + +W ++ +L + L +
Sbjct: 4602 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4661
Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
+A ++++ W+ E + S + + + ++K L +HKEF+ + K + D N
Sbjct: 4662 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4719
Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
++ L + S + + + L E+ +W + G + LE+ L + + +
Sbjct: 4720 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4777
Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
Q L +WL E +L Q I V L+ + + + +L ++ ++ LK+S L
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4837
Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
G+ D +S + Q+ S+ V L S Q+ L+ + + V + +
Sbjct: 4838 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4891
Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
+ ++ + L + L++L D+ + E+ + + K + +V I
Sbjct: 4892 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4950
Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
T K W + +A +++ Q A + A A L + + Q A +++
Sbjct: 4951 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 5010
Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
+ E++P ++++K L + Q E + +D++
Sbjct: 5011 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047
Score = 179 bits (455), Expect = 7e-44
Identities = 674/3683 (18%), Positives = 1386/3683 (37%), Gaps = 526/3683 (14%)
Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
E +LEN+K + E+ ++L + + Q + L L+Y E L RLE A L++T
Sbjct: 675 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 731
Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
+ L R T +W E A +W + ++ K
Sbjct: 732 RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 780
Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
E+ RE LD +E + + + E E L + Y ++ Q + L Q
Sbjct: 781 HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 836
Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
+ Q++ E++ E +E T +Q+ + K ++LVQ ++E+
Sbjct: 837 VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 894
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
+ + N + T Q P S+ K + + I + +I+
Sbjct: 895 EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 942
Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
TI + +A + NE + S + + N ++
Sbjct: 943 I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 994
Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
++Q+ +N+ + WH +NE+D S V I PG+ Q+ + NL
Sbjct: 995 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1054
Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
F+ + + SQ ++ + +QL K V + Y +LLKS E + S ++ +
Sbjct: 1055 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1114
Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
+R L + + + ++ +L S+F E + E + L + ++N+
Sbjct: 1115 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1174
Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
Q S+P ++ + V+ ++V SM + K+KT+ L + E E
Sbjct: 1175 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1234
Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
L E ++ + ++ I+ + ++ E+ + VF LQ K + +
Sbjct: 1235 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1284
Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
E+ K ++ ++D E Q++ + H+ D ++L L+G I + K
Sbjct: 1285 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1335
Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
+D + ++ T + +++ Q + + ++ V+E + + K++
Sbjct: 1336 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391
Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
++ + Y A V++ E++ + ++ ++ P ++ R SS+ I+
Sbjct: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1437
Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
QE + + T ++ ++T DSL + E SL +
Sbjct: 1438 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1496
Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
E+ PP + S + E E T E E+
Sbjct: 1497 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1556
Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
KT L ++ +V VE E + A+ QQ +++L G +LT+ E
Sbjct: 1557 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1615
Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
H+ AF++ E K Q + Q + + + L V N E EK S
Sbjct: 1616 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1673
Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
++ I +K +E + + + +NL EL+ +VT + +K +Q+ E K
Sbjct: 1674 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1731
Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
+ D++ ++ ++++ ++ Q N T + A E++V N
Sbjct: 1732 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1781
Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
G+ L+E V +G TTQ E+L
Sbjct: 1782 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1800
Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
Q+ ++ Q +++ + + + ++ L S EE ++ + +E +V
Sbjct: 1801 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1856
Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
HYET LA S+KK L ++ LE FD EH + +
Sbjct: 1857 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1901
Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
+L+AG D ++KR +I K L+ ISG V A+ K D V
Sbjct: 1902 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1959
Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
+ V + D +R Y+ + L+D++D Y + S +
Sbjct: 1960 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 2014
Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Q + + + E + + + L L++TK ALQ QI + +V +KL ++
Sbjct: 2015 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2070
Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
+LP+ ++T + V + L + + KLQ L + + + +
Sbjct: 2071 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2129
Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
+ S+L V L + IS ++++I G+ + + + K+ + + +
Sbjct: 2130 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2189
Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
L+ ++ L ++ + K L +++ L + + S++L +LE+ L
Sbjct: 2190 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2249
Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
+V++ ++ + + F E K ++ SL + S H +D A +
Sbjct: 2250 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2303
Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
+K+ + + + +E + Q + + + + SW+ +T+ + + PS A
Sbjct: 2304 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2359
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
+ L+ K+ + + K + VN S + L + + E
Sbjct: 2360 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2419
Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
EF + G +++ + + +L KI L L + +++ + +
Sbjct: 2420 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479
Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
WL+ + Q+ P +V+ + + E +L + ELK L
Sbjct: 2480 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2539
Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
++ P + + ID +Q+ R L + + T Q+V L++W + +
Sbjct: 2540 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2599
Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
L V P+ + L Q + +Q L E + + +E+L Q +
Sbjct: 2600 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2646
Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
+ + G PS+ I++E+ ++W + ++D+ + Y + + +
Sbjct: 2647 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
L + K +S + + + L A + +E+Q + ++ K +A ++ S L + +
Sbjct: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2764
Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
++ L G L S Q+A +++ + A+ +F +DF L++ K
Sbjct: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2820
Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
EE+N LD L K++ D LTAQS E + LK S
Sbjct: 2821 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2874
Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
+ A LQ + W ER ++L+ EK L E+ WI +
Sbjct: 2875 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2932
Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
E +K + NS+ +L QK V + A+S LL EI+
Sbjct: 2933 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2983
Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
E +T+ +K L + + + +K ++ + +++++F + R L L
Sbjct: 2984 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3043
Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
++ Q + Y T + + + K + + + A L A + ++ +D K V ++
Sbjct: 3044 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3099
Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
+ + Q+ E ++ ++ + I+E+ S+ + S P+ E
Sbjct: 3100 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3159
Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
L +KE IK + L A N +T K L D++ +K +E L +Q L
Sbjct: 3160 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3219
Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
R R++++E + F K KE L + E + +E M +
Sbjct: 3220 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3279
Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
QK EEI + + +G LI+++ KS + + ++ L+ +N RW+ L +
Sbjct: 3280 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3336
Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
R +L+E + + +L +W+ E EL + + ++ ++ EQ+ LQR
Sbjct: 3337 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
++ + VE V+ + + A E D ++ + LD RW + + R
Sbjct: 3396 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3448
Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
++E + Q+F + +WL + E+ + +E++ + +A + I
Sbjct: 3449 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3508
Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
++ L Q I + + L+ RE++ S+L + +Q W +Q + + L+
Sbjct: 3509 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3563
Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
+ F ++ WL E+ +L+ +V+ +S + +L Q++I L +DQ
Sbjct: 3564 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3623
Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
++ G +L++++ + ++I+D+LE + +++ + + RRL S
Sbjct: 3624 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3683
Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
CT + E E ET + P+E++ ++ + + + S +
Sbjct: 3684 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3743
Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLK 6457
P R G E V+ D+ + D E D + L + + +A L
Sbjct: 3744 VPWRAREGLEKMVAEDN--ERYRLVSDTITQKVEEIDA-----AILRSQQFDQAADAELS 3796
Query: 6458 MTTKTLKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKL 6517
T+T K K +S G ++E D+ + + + K
Sbjct: 3797 WITETEK----KLMSLGDI---------------RLEQDQTSAQLQVQKTFTMEILRHKD 3837
Query: 6518 LLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQ 6577
++ D K G +++ ++E + ++ +D I ++ + + +
Sbjct: 3838 II---DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
Query: 6578 QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVN 6637
Q + WL +T++ + L P + + + + + +++ + +K + +N
Sbjct: 3895 QFWETYEELWPWLTETQSIISQL--PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3952
Query: 6638 VSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLL 6697
+ + L+ E +Q + L+ + V L +++ Q FH +L
Sbjct: 3953 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4012
Query: 6698 LWLASAKNR-RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 6756
L R RQ ++ A+ + E E + ++ + QP + L++ ++ +
Sbjct: 4013 ESLERIVERLRQPPSIS---AEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4069
Query: 6757 GHGEDCIEAEEKVHVIEKKLKQL 6779
G D + ++ KL Q+
Sbjct: 4070 SGGTD---KDISAKAVQDKLDQM 4089
Score = 174 bits (440), Expect = 4e-42
Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)
Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
LQ Q E K F +KL A ++ + K +L ET + V + LE S+QC
Sbjct: 3161 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3217
Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
LL + + +E K LE S L S+ L+++ +++ + +G +
Sbjct: 3218 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3267
Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
+ Q LN +GKQ S S LE + + +W
Sbjct: 3268 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3327
Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
+LNKK+ +LQ L H + + L W+ ++ + K S + ++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3383
Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
+ I + +D++ S + G ++ E D + L+ + +W L+ +
Sbjct: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
+L + + + + + W+ +E + + + + + AS+++ + +HK
Sbjct: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3501
Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
++ ++ + + V+ QSL LS+ + + + +F++ W+ + +
Sbjct: 3502 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3554
Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
+ + L+Q L + E++++++N WL ++L L Q+ E + +
Sbjct: 3555 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3613
Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
+LL Q+++ L L+ LKQ+ V +++D I ++ + + T V +
Sbjct: 3614 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
L+ ++Q + +++L ++ + + + + V+ E + Q+ + L+ E
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3722
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
A++++ + L EV L L P A E +E+ ++R+ V+ I ++++ + +
Sbjct: 3723 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3782
Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
+ + A + + + E K L +I + QD Q VQKT
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3830
Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
L++ ++D L + S H ++ S + ++K L ++ + + +
Sbjct: 3831 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3884
Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
+LE + L+ E + L E S ++ + A + + E +L
Sbjct: 3885 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3943
Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
K + MN+ T L S +G + EK++ + Q+ E + +EA+
Sbjct: 3944 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3998
Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
K+D + SL ++E+ + + AEV I + I++ S + LQ L T
Sbjct: 3999 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4058
Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
++ R E + S TD+ +A + + +D +V W++ T VE
Sbjct: 4059 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4113
Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
+F D L+ +K + F S+ + + E +EI + +
Sbjct: 4114 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4173
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
L G +L+ K V + I +L +W + + I + + ++ Q + ++
Sbjct: 4174 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231
Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
+ + + + P + DL K+ I+EL+Q + Q E++ + +A+L
Sbjct: 4232 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4290
Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
+ E D +++ + L W+ L R+ R+ ++E L F EL AWL
Sbjct: 4291 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4350
Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
E + + + + IE + ++ L ++ ++ + + G+ LI++S A+ +
Sbjct: 4351 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4410
Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
+KL +N RWQ++ + R ++L + + +L+ WL E L SKP+
Sbjct: 4411 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4469
Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
+ + EQ ++ ++ A E+ ++ C E + I Q
Sbjct: 4470 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4522
Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
+L +W ++ ER+ K+EE L +F + F +WL AE+T + ++
Sbjct: 4523 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4582
Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
+ ++ + F +++ Q+ ++K L ++ +K ++ RW+ +
Sbjct: 4583 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4642
Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
+R+ R L + ++F ++ WL E + L + +E ++ D ++ Q
Sbjct: 4643 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4702
Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
FQ+ + + D G L +K+ D L ++D L EL + G+
Sbjct: 4703 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4755
Score = 160 bits (404), Expect = 5e-38
Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)
Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
LT S LS G T+ L + A T G+ + + P+ SL+ KL +I++
Sbjct: 570 LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 627
Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
+L K S++ L E +I L + E++ Q + SDL + + S L++H
Sbjct: 628 LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 681
Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
KN + + +LKE + SE + + KL LE + +K+
Sbjct: 682 ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 731
Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
++ ++HL H +S + L + E + A + + + R +D H L +
Sbjct: 732 RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 787
Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
L +EE K ++E E+ L +A A + Q+ + QL ++++ +
Sbjct: 788 LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 847
Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
E EAT + + +++ + + ED Q + +++ + I
Sbjct: 848 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 907
Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
++++ L PL E I K E +L A+ + I
Sbjct: 908 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 967
Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
+ P V K D++N Q+ N L L + SH + YL ++
Sbjct: 968 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 1025
Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
D +R + K G +H Q + ++ FL+ +Q D+T L KE+
Sbjct: 1026 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1081
Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
Y E K+ E+ L +++ + L++Q++ ++ D H
Sbjct: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141
Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
+ E + + + L T+ N +EF S + + +L + + N++
Sbjct: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
T L V +NT + + + K + E + + K +E + S
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1254
Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
LK RS EK+ F E Q + + ++ L+ DW K D VE +
Sbjct: 1255 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1314
Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ ++ + +S+K D +++ Q ++ Q E + L TQL +
Sbjct: 1315 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1374
Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
K + +E EC E + L + Y A +D+ ++ + ++ + S
Sbjct: 1375 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1433
Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
++++F + Y+ S+K L +++SL+ + V +++K++
Sbjct: 1434 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1493
Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
++I K K KI E +S + + L Q+ +HG + +++ +
Sbjct: 1494 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1552
Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
+ +QV E F+ + ++Q+++ S ++ +++ + R + +E+ +
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
T+ + H + + G +++K+ ++E+ KN E N LK+
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1669
Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
E L E L+L+AE K+ D + +KE + A L E
Sbjct: 1670 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1729
Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
I L D ++ + H ++ + ++ EE + L T
Sbjct: 1730 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1789
Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
+ T E+L QYQ + V+ +TQ +Q L LE++ + + K +
Sbjct: 1790 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1846
Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
L E + A +E ++K H + Q+EL++ D+ + L +EL
Sbjct: 1847 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1902
Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
E D + L + R + F ++ + HK R + + E A S + +
Sbjct: 1903 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1956
Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
+ ++ V+ ++ + DR ++ KC +L LK + D D S L LQ
Sbjct: 1957 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 2015
Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
K L E I K L EE Q +S + ++KK EV+L A S
Sbjct: 2016 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2073
Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
+L + + K L D+I+ + + + EK + + + D L ++L
Sbjct: 2074 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
M +E S KE L+ QD + ++ + I + +N ++K D
Sbjct: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
A Q + S + A K +E ++ +++TK+ FE+L +L T ++ +T L
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2243
Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
+ L++Y +E+ + +E LE + ++ G P + + L K
Sbjct: 2244 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2302
Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
L ++D + EK ++S + +L L+ ++E K ++ +F A++
Sbjct: 2303 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2362
Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
+ LE+ K K++E +++ V +S S + +A+ ++ A+++
Sbjct: 2363 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
+T E + L ++ T E+ G+ L ++ L K L +A +E
Sbjct: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2477
Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
W +++ + +W+ + EA+ Q + E + +EL + L L
Sbjct: 2478 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2537
Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
+ + K Q L L + R + ++ + +TV A ++
Sbjct: 2538 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2597
Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
KE +L + + ++ T+ Q+ +E K ++Q T + Q + + + S +
Sbjct: 2598 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2657
Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
E+L ++ +K + + R + + + + +S + L D+D K+S+
Sbjct: 2658 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2715
Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
+ S+ AM +++E +++ +QQ+ K I+ AQ + + + + + K EL
Sbjct: 2716 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2770
Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
+++ I VEQ + + + Q+QQ+S+ + + + NK+ +
Sbjct: 2771 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2830
Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
K++ L+K E I +LL + L T+ +
Sbjct: 2831 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2890
Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
T ++ AL+ EQ L + +LE++ + E SI +
Sbjct: 2891 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2950
Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
L + + Q ++E L V I+ EV KS+ ++V + L SK+
Sbjct: 2951 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 3010
Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
+ ++ + EV E+ R ++ ++ L + QT K L +
Sbjct: 3011 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3070
Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
+L QD+ + +E + QE + L + V ++ + + +++ +
Sbjct: 3071 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3130
Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
N FS D+ D + + + E ++KQ I + ++ E L+
Sbjct: 3131 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3190
Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
L E+ G++RD L A++ + + +R A R+ G++ L +++E S
Sbjct: 3191 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3248
Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
+ +KAE +S + ME + TI Q+ +M ++
Sbjct: 3249 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3283
Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
+ + QG + + + + +T +E D D + L +V + + E
Sbjct: 3284 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343
Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
L C V EL Q + E + + A +Q Q L Q+L+ +
Sbjct: 3344 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3403
Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
E+ K+A E K + L EAL K +T LE + ++ Q+ H
Sbjct: 3404 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3461
Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
E L+P+N L+ +E + Q ++Q+ + K +E D
Sbjct: 3462 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3504
Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
I + +H + + SS E+ D+ S L D Q +
Sbjct: 3505 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3545
Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
E+ K L + + + V + N+ L ++ + S L
Sbjct: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3591
Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
Q+ TE L K+ EL + L +V++ L + +G +V L
Sbjct: 3592 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3647
Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
E +K Y ++ D+ K + + L + L L+ + + + G
Sbjct: 3648 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3707
Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
+ +++ Q K L + K+ +L SLNE+S + +A E E VA
Sbjct: 3708 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3757
Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
++ ER L + Q+V +++ + +A ELS ++TE+++ + G + L
Sbjct: 3758 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3814
Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
+ QT +++ +Q +I HK LV + ++ A S + S+ +
Sbjct: 3815 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3863
Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
+ T +I E+ Q + Q WE ++E + L + + +IS LP+ +L
Sbjct: 3864 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3922
Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
ET + E ++Q++ I + + G QL+ EL G+ ++E++
Sbjct: 3923 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3973
Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
++ L +I ++ + L +S + D++ + LES + + + Q ++S ++
Sbjct: 3974 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 4032
Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
+ I+ I+ S ++++ L + G +++ + A Q + +
Sbjct: 4033 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4086
Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
Q+ I E +H L E+ + E+ W +++ + +D+ + P S
Sbjct: 4087 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4146
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
VK + + R E+D Q +D V N ++ C K + + + E+N W
Sbjct: 4147 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4202
Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
++ +I LE+ +++ + ++ +Q + +W++ +L ++ + + K
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4258
Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
Q IE KS+A + + L A LL+ D EL S+
Sbjct: 4259 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4316
Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
++ + ++ L + DE+ + KPV + + ++
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4376
Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
LQ++ + + + E + + L + A ++ K + ++RW V + + Q+
Sbjct: 4377 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4436
Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
L+ K + HGE L+Q + + LA+ + G E L ++ +
Sbjct: 4437 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4492
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
+ K + +L R P+ AE++ + +++L +R LE+ L
Sbjct: 4493 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4548
Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
+ A EF L F ++ + E + LD + Q E+ F N V + Q
Sbjct: 4549 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4606
Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
+++ HL S K + V +K L ++ +W + +ER L K +
Sbjct: 4607 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4664
Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
E W +L+E +EE+ K +++AN ++ Q +K + + ++ D+
Sbjct: 4665 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
L + T + ++ + S+L D+W +R+ ++ + FT +++ L
Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4782
Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
+L L+ E ++ L+ L + FQ+ +RT+ L+ + L+
Sbjct: 4783 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4837
Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
V ++ +L W+ + + +L ++Q F S V + + E
Sbjct: 4838 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4896
Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
R + ED L L + KE +K+LE+ A L + TM +
Sbjct: 4897 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4949
Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
+ + +K I + ++E++ +Q + L + E + L AWL E +
Sbjct: 4950 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 5009
Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
I + IE++ K + E F E ++ KQ + + K RAA+
Sbjct: 5010 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5057
Score = 155 bits (393), Expect = 1e-36
Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)
Query: 616 ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
++L + E +L E VE + ++ S+ISK L+ K + SK ++
Sbjct: 1463 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1522
Query: 669 ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
+ L + K D N L K+ K E FS + +
Sbjct: 1523 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1582
Query: 714 QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
++K EK E + E+ +L+ D+ +LIG E + ++ + E
Sbjct: 1583 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1641
Query: 768 ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
E K + E++ +E+ L+ + + +S ++ ++ K+ EAK K +
Sbjct: 1642 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1695
Query: 828 VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
+K + K L V + + ++EES+ ++E+ + + E G +
Sbjct: 1696 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1752
Query: 880 KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
KHK+ + + T K+ +E+ N+ E D+ + ++ +++ + +
Sbjct: 1753 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1812
Query: 935 LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
+ Q + I + + +L+ + Q ++ E+K + K L +E +E +L
Sbjct: 1813 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1872
Query: 994 HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
H ++ EEL E + L+ EQ++E L A +I+ + S +E
Sbjct: 1873 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1926
Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
I T S NR + +K D A ++ L +
Sbjct: 1927 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1984
Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
++ L+++Y Y D L LQ + + S LQ +L + +
Sbjct: 1985 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2044
Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
++ + ++ E + E + NDI+K D + R +L ++
Sbjct: 2045 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2099
Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
N R E L+ L L V+ S L +PL+ A+Q D I
Sbjct: 2100 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2152
Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
+++ QD +Q I N + E ++ P ++Q + +F +H+
Sbjct: 2153 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2211
Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
V+ E+ + L+ FL + L + + VT+LS + E
Sbjct: 2212 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2271
Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
K+ E L+K+ + H DK L + L FK+ E + TSC+ LDAF
Sbjct: 2272 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2331
Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
+ + + +E T++ +++ F +L K+++D + K LK P + V +
Sbjct: 2332 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2388
Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
SL L + + ++ N+ + + ++ + + +
Sbjct: 2389 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2448
Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
E+ L+ + + + L L++ Q S + +QK + + + +
Sbjct: 2449 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2508
Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
+E K E + V+K+ ++ L L + E P K+ +D +W ++N+ T
Sbjct: 2509 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568
Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
D + L + + ++ + +W EK L L L+ D L + Q +
Sbjct: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2627
Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
EF+ R + + L + + L + S+ ++ +T + + +L+G ++ + +
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2685
Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
DQA + +SLL++LS S SL + T +EIQQ+
Sbjct: 2686 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2745
Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
Q K + L E+ + E +EL +Q E + F + ++H L
Sbjct: 2746 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2805
Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
++F W K + S +E ++ DF TL ++ ++ + +
Sbjct: 2806 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
++ + L L + + + R +L++SL++ L+ ++ L W+
Sbjct: 2866 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2925
Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
N E+ K +P GE + ++L ++ +Q F V LNN+ KE
Sbjct: 2926 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2985
Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
E + +I + + ++ + ++ E+ +E K
Sbjct: 2986 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3045
Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
+L T+ +S L H V K + + L+V E K
Sbjct: 3046 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3094
Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
+LL+ E A+ + + Q + ++ L I + + + S + ++L
Sbjct: 3095 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3154
Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
+ E + KE ++ L +L+ AL K+ + + DL + +
Sbjct: 3155 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3207
Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
+L++ Q N LL+ + + E+ IK L E S L++ +Q + EH+ Q
Sbjct: 3208 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3261
Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
V T++ F F + + E LQ Q+ N L L +S
Sbjct: 3262 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3306
Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
++TS+ G + DD+ + + K + R A ++ + C L S+L TE
Sbjct: 3307 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3366
Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
+ L +K +++ V+ QE +++L +D E+ K ++A + +
Sbjct: 3367 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
+ + Q S+ ++ E +N E +N+ LE +++ NE L IEK
Sbjct: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
E LE+ +K ++ HN IG S + L + + K S
Sbjct: 3482 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3541
Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
Q + + QE + ++ L + + ++ + +L+++ ++ + + S L
Sbjct: 3542 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3600
Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
W+ S V D L + + Q L +G E ++Q IQ K Y +
Sbjct: 3601 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3657
Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
T L V T +Q L RL S E +++ + VLKG
Sbjct: 3658 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3710
Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
QA+++ K + E K K L D +N + W E L + AE+ ++ I
Sbjct: 3711 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3770
Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
K++E + W +L I L D +Q++ K
Sbjct: 3771 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3830
Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
IL + ++ L + + + + E + L+ + Y + +++R QLE
Sbjct: 3831 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3890
Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
+ F+ + + E+++ II ++ A E E TL Q+E +++ I+
Sbjct: 3891 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3943
Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
H + + + EL+ E ++++ ++I+ ++ ++ I Q
Sbjct: 3944 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 4003
Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
FH+K + E S++R L Q + + E+ +K++++ K + + KL+ +++
Sbjct: 4004 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4058
Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
+ G + D S +LDQ+ T V E+E +L + ++ + F
Sbjct: 4059 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4118
Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
+H + + DL+ + V+K + E+ R L + ++ L E
Sbjct: 4119 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4178
Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
+I E D +K I ++ D L K ++ + +L QD L+
Sbjct: 4179 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4232
Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
++ +L I +++ ++ + + EA+Q+Q+ E + +A ++K
Sbjct: 4233 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4292
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
EE S+ V+ L E + + L I R + L A L +++ A+ + +T
Sbjct: 4293 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4350
Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
E ++ + VG +++E+ L K L++ V Q E + S+ E
Sbjct: 4351 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4409
Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
LQ L+ L + + E + ++ + + L K + ED+ L+ E L + +
Sbjct: 4410 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4469
Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
LP + +E L +E A + + K + K +Q+L RC ++ + + ++
Sbjct: 4470 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4525
Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
L EKW S+ E + EE W +E+ R ++ILD +
Sbjct: 4526 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4585
Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
++ E + + + E++ EL L Q + V + LL+++ + + +Q
Sbjct: 4586 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4645
Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
+ E +++ A+ ++ E K L ++ + + ++T++ + F
Sbjct: 4646 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4705
Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
K + A + + T + +++ + D+ + + EL Q+ L++
Sbjct: 4706 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4765
Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
L + L+ +Y + P E Q + L D + E+ K + S
Sbjct: 4766 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4825
Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
A++R E+ G + V+ +Q+ S E + L+ + E S V
Sbjct: 4826 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4885
Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
++E + G + D L Q+++ ++ E + ++LNKAT +
Sbjct: 4886 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4945
Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+ D + + + WI + + L H + AL K LL ++
Sbjct: 4946 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 5000
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
L+ TD+ + I + +V AL Q ME + + Q D V
Sbjct: 5001 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047
Score = 155 bits (392), Expect = 1e-36
Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)
Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
+L L+S+ ++L + ++ FS +++ Q Q+ +++ + +E Y +
Sbjct: 1048 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1107
Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
++++ N + D+ + QI + L E R++ Q+ K++ L
Sbjct: 1108 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1159
Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
KDD+ ++ +C++ + +S+ + LN +L++
Sbjct: 1160 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1207
Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
+ + + + V ++TQ + A+ KL E +++ + + + ++ + ++ DE+
Sbjct: 1208 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1265
Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
+ +ELQ D M + + +++ + K+ A + +E+ + ++
Sbjct: 1266 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1316
Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
+DN L+ L + K+ + +++ VE++ + + +E+
Sbjct: 1317 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1362
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
T L++ K ++ IE ++ + + E S V D + + +++SQ K
Sbjct: 1363 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1422
Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
+ I +++ Y TLM + D+ L+++++ L+ K
Sbjct: 1423 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1482
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
E+A +LQ S AE K + K+K + E+ ++ E L
Sbjct: 1483 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1532
Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
+ + L K + RN++++ + L S LL + L Q+++ + + D
Sbjct: 1533 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1584
Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
+ ++ V +E K+K+ LT E + + + + + K + ++L+
Sbjct: 1585 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1644
Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
++ + A + K + + QE + LI E EA++K + L+A Q
Sbjct: 1645 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1700
Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
+ +E+D ++T ++E T E++ QL+ K + + ++ N + E
Sbjct: 1701 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1750
Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
+Q E+ +E D N LL +V+ V NL + +K
Sbjct: 1751 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1810
Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
+++ + + Q Q E++++L++ +K+L E AL
Sbjct: 1811 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1865
Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
+ + L E+ D + L Q Q +E + D+I + KL K+F
Sbjct: 1866 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1923
Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
+ + + + D Y + N VLE + ++D +++ L
Sbjct: 1924 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973
Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
H ++ +S + ++ +K + ++ + E + A + + +A TA + E + +
Sbjct: 1974 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 2032
Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
+++ +L E + LQ Q+++ + VL DA +L K + + ++ I
Sbjct: 2033 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2088
Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
VG E+ + + E+L+ T+ +QD L E L + + E+ L+ Q
Sbjct: 2089 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139
Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
LQ+++SKN +++ +++ E K + + + ++L L
Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199
Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
S ++E L ++E+ K V + E KL+ L TE D G + ++
Sbjct: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2256
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
+ E LE K E+ LK+ S + + A++L+ NL ++ E+ T
Sbjct: 2257 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2313
Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
KEA T+ CQ E ++ Q+L+ L I+ + VP
Sbjct: 2314 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2352
Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
Q ++ K L+ +K +E + E I+L N TT + +A
Sbjct: 2353 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2411
Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
+ +E+F KG + + M + Y ++ ++ AE+ +++
Sbjct: 2412 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2466
Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
+ +KA E+ +K++ K + A E + + + + +N+ K
Sbjct: 2467 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2525
Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
QE++ K+ + L+ W L E+DS+ Q++ + D Q E N + FQ
Sbjct: 2526 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2585
Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
Q +Q E S Q + + ++E++ E
Sbjct: 2586 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+L+ P + SLR LS + A+ S Q +LL S+
Sbjct: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
L DL + + + NQ QK+ + + Q Q + +D+ A+ E
Sbjct: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765
Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
+ +++ IL S + + E H++H + + ++ + ++ + Q
Sbjct: 2766 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2825
Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
P+ + +LE++ ++ + K + Q++ +++ I + +L
Sbjct: 2826 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2868
Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
L+ ++A +L ++ + KQ+ N+ KE L + K V L + +
Sbjct: 2869 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2928
Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
Q +E + +E E +A+ + ++++ N S+ + +++EV
Sbjct: 2929 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2988
Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
KS D E+ ++ + K+ +E S S +Q A ++ D+
Sbjct: 2989 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3046
Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
+Q + L Q + SL+ + + + D +++SD++G + +VE E
Sbjct: 3047 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3106
Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
+ + + + LE LQ N E + A+ + L++Q
Sbjct: 3107 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3166
Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
+A L ++E +A +TCK ++ D + + EALS + L +
Sbjct: 3167 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3226
Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
E+V+ L+E +S+ + +IL + +E EH+E+ PV + E E+I Q + K F
Sbjct: 3227 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3281
Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
Q++++ L+ +Q +++ I+ AK Q +HD D T + A A
Sbjct: 3282 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3341
Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
E D +S+LS W EL + K P L
Sbjct: 3342 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3393
Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
+L++ + ST + IL +++ + R+ + +T QLE +
Sbjct: 3394 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3453
Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
A E ++K+L +Q S +EE + + +D H
Sbjct: 3454 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3511
Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
L+ A+S G LK ++ E+ +++ D QV Q + RS+ L
Sbjct: 3512 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3559
Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
+ L + + + L + L + L + S+ + S + + +Q + ++ +
Sbjct: 3560 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3619
Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
V + G L L EV ++D L++ ++ARY +++ S V ++ + AL
Sbjct: 3620 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3674
Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
L E L K+ E L++ + K + A QAQ+ +N+K L
Sbjct: 3675 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733
Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
V+ LL +++P W + K++ E + + + ++ QK EE D
Sbjct: 3734 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778
Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
A++ + + + +S + ETE++L+ ++ S Q+++ + R
Sbjct: 3779 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3835
Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
+++ G +++ + S E + KL+ + +N + +L R Q+L+
Sbjct: 3836 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3895
Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
+ ++L WL +Q ++ +L + +T+R + + + E
Sbjct: 3896 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3948
Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
+ G QLL L + +++ + ++ + + L + + I
Sbjct: 3949 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 4008
Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
+++ + + + S+ + ++K + ++K ++M+ Q + + + Q ++
Sbjct: 4009 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
+ D+ +K + + L +M W +H ++ + L ++E +
Sbjct: 4067 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4121
Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
L ++ ++ ++ L+ P SV K Q+ + + L E + L S
Sbjct: 4122 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4178
Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
+ + IDEL S+ ++++L+ +MQ+ +Q ++D V+
Sbjct: 4179 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4238
Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
+ + + P+ LET++ Q+E L+ + EA + E+L L K
Sbjct: 4239 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4294
Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
S +++ W + + I ++ K + L + +A E A L E
Sbjct: 4295 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4354
Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
+ + G+ A + A + LQ+DV Q T EA + + L E+S
Sbjct: 4355 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4409
Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
L L L QR + + + + + L Q K F +E L+ + E +L
Sbjct: 4410 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4467
Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
L + KE + + A A+ + L ++ + P S + + N+
Sbjct: 4468 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4527
Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
+W ER ++L+ + L +F + +I L + E+ L V S P L+
Sbjct: 4528 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4584
Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
+++ E +V N+ +S+ Q ++L T T ++ ++ + + L RW+
Sbjct: 4585 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4642
Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
VQ + +R +D ++ + F + L +L ++ L S ++ +T+ H+
Sbjct: 4643 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4702
Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
K + + + T G L T L + +S+L+D W + + E
Sbjct: 4703 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760
Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
+ + + Q ++ L L ++ Q + P +H D+ LI K ++ L
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4819
Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
T +++ L+ +L +D +K Q++ L +WE +C ++ +E L
Sbjct: 4820 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4878
Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
F+ L WL + E VL + ++ +I++ K+ M+++ +
Sbjct: 4879 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4937
Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
MGD ++ + I + I R++ + ++L A + + + L
Sbjct: 4938 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4997
Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
WL E+ L+ K V+ + +E++ +AE Q ++ + V+ V
Sbjct: 4998 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5055
Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
D + ++T+ ++ L +W+ + +++E
Sbjct: 5056 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5115
Query: 6127 RRMKIEE 6133
RR K+ +
Sbjct: 5116 RRRKLND 5122
Score = 146 bits (369), Expect = 6e-34
Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)
Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
P+ +AM P++ F++ P +E++ +E+ Y + E + + ++ H+L
Sbjct: 967 PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 1022
Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
N RI S+ +S + Q L++LQ + +E ++ S +LE VN
Sbjct: 1023 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1082
Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
K+ + ++ LK ERE Q + R+E+ E L ++ P+E+
Sbjct: 1083 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1138
Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
L H+ F + + +++ + L ++D + I N+ EE +
Sbjct: 1139 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1183
Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
L + N++L+ Q M+ D LK + L + + A+ + T L +
Sbjct: 1184 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
+A +N + T+K E+ H ++D KAK + K K D+ F
Sbjct: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
+ D E N+ +L + G G ++ + L+ I + + IQ+ Q
Sbjct: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
+ SK T+ +++K L+ ++ + +E +++ ++ + ++ KD +T+
Sbjct: 1361 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1411
Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
+ ++ K+ V Q L +++++ + ++ T L+ + Q
Sbjct: 1412 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1461
Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
++LK+ E + ++EE EH+E ++ + N+ L + +PPF K+
Sbjct: 1462 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1515
Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
+E+ E L AL I + K KM T+E+R L++++
Sbjct: 1516 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1558
Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
+ + E FS + ++Q S ++ +E +++ I + + + L
Sbjct: 1559 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1618
Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
G + T EL+ + + K G ++L + + +++ E KL + +
Sbjct: 1619 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1678
Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
+++QK L E +I C L + + KK+ + V +++ +L + K
Sbjct: 1679 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1734
Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
N DW SN+ + + F+ + K ++ ++ + + L
Sbjct: 1735 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1794
Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
T E N + ++V + ++ + + +++ GQ E+ E + Q KE
Sbjct: 1795 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1853
Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
L+ SLQ+ L D D+ WL E++ + +E +
Sbjct: 1854 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1913
Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
L R++ E V L+ + + +C
Sbjct: 1914 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973
Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
DR+++L + + + K L + Q + D +A D
Sbjct: 1974 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2033
Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
+ ++++E+ + + E+++K E++L DAR + + + +Q
Sbjct: 2034 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2082
Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
KTL DI ++++ L+ + EKL + + L ++ L ML +E K++
Sbjct: 2083 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139
Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
L A I K + QD+ +S N + E K + +P
Sbjct: 2140 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2185
Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
SL +++D +H + +L T + +N S++ +F + +
Sbjct: 2186 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2245
Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
V E Q +QE + L+ + +L K + + + ++ + +L
Sbjct: 2246 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2305
Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
K K++E+ + K+ + C ++KS +S K+ +P + D+ +S
Sbjct: 2306 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2365
Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
+++ +KL+E W EI K A+ S LN + +
Sbjct: 2366 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2422
Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
NTE+ ++ + ++ + +L +L+++ E KL +A++ + ++
Sbjct: 2423 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2482
Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
+ +NKT T + +A+ T +++NK + E+ +
Sbjct: 2483 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2519
Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
K + + LK D +T L + + K L + KW+ L+ D +KL
Sbjct: 2520 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2575
Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
ES + Q ++ + Q +VE + +++ + L Q+Q +Q+ L+
Sbjct: 2576 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2629
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
R Q T G +L E + +++ + + ++W++L
Sbjct: 2630 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2674
Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
+ + I + +++ +++L + +L +L+ S+ + PD + Q+ +
Sbjct: 2675 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2734
Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
I ++ + ++L E++ V Y ++L+ LE + ++ + K+
Sbjct: 2735 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2792
Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
Q L+ F + R FQ + + E + K H ++ LE+
Sbjct: 2793 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2840
Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
K+ ++ ++ +H+ E T N+ + E+ L+ QL +K + + ++
Sbjct: 2841 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2900
Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
N+++ ++ ++ E+ L D Q N E+ + +G ++
Sbjct: 2901 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2960
Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
+ + + L +L V ++ K ++D + Q+ K+ LE ++
Sbjct: 2961 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 3020
Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
F+E + K Q +K +D+ ++ + ++++ + Q L +++ AK L
Sbjct: 3021 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3079
Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
+++ + +++K D +LQ++ A+E+ L + + L K + Q+ +
Sbjct: 3080 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3134
Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
+ +L + + + +Q +K+ +AF +++ A M S K
Sbjct: 3135 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3194
Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
+ D+ R+ E L Q N +D L + Y L + + +A
Sbjct: 3195 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3254
Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
E S P ++ + L M + ++EE+E QD+ G+I S
Sbjct: 3255 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3310
Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
Q +L N+ K K A + E + ++ + + LS M E V
Sbjct: 3311 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3370
Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
Q S ++ ++++ K L L K + +++ + D + +LK
Sbjct: 3371 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3428
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
+S L +W +LL A+ E + + E +E L +++ L E T+
Sbjct: 3429 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3488
Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
+ E++++ L D + + +++ + + + + + + E V++ F ++
Sbjct: 3489 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3543
Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
+ ++ +K EL+Q + F ++ + L N+ + ++ QD+ +
Sbjct: 3544 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598
Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
+Q EL+ + + L +N+ + L + E I+ ++E + +DI
Sbjct: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3657
Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
K+S +V K+ + + R++ EE+ L VE L K + +AQ K
Sbjct: 3658 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3717
Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
++ E + L+ L+ ++E P +A+E ++ ++ ++Y+ VS + ++
Sbjct: 3718 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3777
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
+ A ++ +++ + +WI T L + D L ++ Q+ ++ + L
Sbjct: 3778 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3833
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
H + D+L +S ++ + + Q + + L ++ + D + I SE
Sbjct: 3834 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3882
Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
+ + +S++ L E EEH + E+I
Sbjct: 3883 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3942
Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
E +I M KT +++ P G + + L IK E+V +++ L
Sbjct: 3943 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3994
Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
I Q+ ++ ++I+ + + SLE + ++ + P + E+E++++QI
Sbjct: 3995 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4040
Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
+++ VD++ + L++ LKQ E
Sbjct: 4041 ENKNVSVDME-KLQPLYETLKQRGE 4064
Score = 90.9 bits (224), Expect = 4e-17
Identities = 379/2122 (17%), Positives = 783/2122 (36%), Gaps = 342/2122 (16%)
Query: 4938 RLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQ-----DLDTIRSNINNFF 4992
R L LL N +++ ++ Q LN+ E + + + DL ++ S++ N
Sbjct: 625 RKPLLKSSLLDQNLTEEEIN--MKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHK 682
Query: 4993 EFSKEVDE-KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
+ ++E +SSLK A IS LK T L + E ++ L+ + + L
Sbjct: 683 NVHRAIEEFESSLKEAKISEIQMTAPLK----LTYAEKLHRLESQYAKLLNTSRNQERHL 738
Query: 5052 HQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYK 5111
L SR A E+I W+N E + D ++ ++ K H E E+D K
Sbjct: 739 DTLH--NFVSR-ATNELI-WLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQK 791
Query: 5112 QWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQ---L 5168
+ + V + QL + R + M QW + + QH+++
Sbjct: 792 EENIKSVQEIAEQL----LLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 847
Query: 5169 LESITESENKIQILNNWLEAQE-----ERLKTLQKPESVISV----QKLLLDCQDIENQL 5219
E +++ L N +A + +R ++ K E ++ ++ LL + L
Sbjct: 848 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 907
Query: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEW 5279
K+K + +LK + PL + +++ + + ++ + S +W
Sbjct: 908 MGKAKTIIQLKP-----RNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKW 962
Query: 5280 KIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAE---SSEGSWEK 5336
K+ +E + ++ F + + V L+ + Q +N+ +L E+ S SW
Sbjct: 963 KVISPTGNEAMVPSVCFTVPPPNKEAVDLA-NRIEQQYQNVLTLWHESHINMKSVVSWHY 1021
Query: 5337 LQEVIGKL--------KGLCPSVAEIIEEKCQNTHKRWTQVNQAI----ADQLQKAQSLL 5384
L I ++ K + P + + Q+ + + + +Q + + + +
Sbjct: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081
Query: 5385 QLWKAYSNAHGEAAARLKQQEAKFQ----QLANISMSGNN-----LAEILPPALQD---- 5431
+ K Y ++A R +Q+E+ + ++ NI + N + +I P +D
Sbjct: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141
Query: 5432 --------------IKELQHDV----QKTKEAFLQNSS-------------VLDRLPQP- 5459
++ L+ D+ K +E F Q ++ VL + Q
Sbjct: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
Query: 5460 AESSTHM----LLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMH 5515
+ SST++ + L + Q A L K+ K E E V++ + + +LK
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261
Query: 5516 EEENLDRLHQQEKE-NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQ 5574
+E H E E ++ + T + D++ D + + +
Sbjct: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF-----------DWHKEKADQLVER 1310
Query: 5575 WIRATATALERCSELQGIGLNEKFL----YCCEKWIQLLEKIEEALKVDVANSLPELLEQ 5630
W R +L+GIG + K+ + + WIQ +E + ++ + + L Q
Sbjct: 1311 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1370
Query: 5631 QKTYKMLEAEVSINQTIADS---YVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQG 5687
KML +E+ + Q+ D Y Q + E++ + + D Q +
Sbjct: 1371 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT-----YRAMVDSQQKSPVK 1425
Query: 5688 VRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL--SAVKGQERFSLYQTRSLIHELK 5745
R+ + D +++++ D T L +T S + +E + H K
Sbjct: 1426 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1485
Query: 5746 NKEIHFQRRRTTCALTLEAGEKL---------LLTTDLKTK-ESVGRRISQLQ------- 5788
KE+ Q+ + + TL+ EK + + ++ TK E + + +Q
Sbjct: 1486 AKEL--QKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1543
Query: 5789 -----DSWKDMEPQL-----------AEMIKQFQSTVETWD-QCEKKI-----KELKSRL 5826
+ ++E Q+ +E +KQ Q + + D + E+KI +E K +L
Sbjct: 1544 DKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL 1603
Query: 5827 QV---LKAQSEDPL-------------PELHEDLHNEKELIKELEQSLASWTQNLKELQT 5870
Q L Q+E+ L EL + ++EL K+++ S + + +K +
Sbjct: 1604 QGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN 1663
Query: 5871 MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNK--- 5927
+ + ED ++++++ + E L L+ K+E+ D++ T + E K
Sbjct: 1664 FLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL-DKVVTTAIKEETEKVAA 1722
Query: 5928 ------------ELCAWLVQMENKVLQTADISIEEMIEK--------------------- 5954
L WL ++ K + A +++IE+
Sbjct: 1723 VKQLEESKTKIENLLDWLSNVD-KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN 1781
Query: 5955 ---LQKDCMEEINLFSENKLQ---------------------LKQMGDQLIKASNKSRAA 5990
L+ D ++ EN Q Q L++ + +
Sbjct: 1782 GNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1841
Query: 5991 EIDDKLNK-INDRWQHLFDVIGSRVKKLKETFAFIQQLDK---NMSNLRTWLARIESELS 6046
E +KL K + + H + KK+K T + ++L+K + + WL + E EL
Sbjct: 1842 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1901
Query: 6047 KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANET--ECD 6104
+ D + +L Q+ D+ H + + + +L + +C+ + D
Sbjct: 1902 N-LEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1960
Query: 6105 SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED-------WLKSAER 6157
+ T R + R+ + K + +D Y +ED L++ E
Sbjct: 1961 T-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA 2019
Query: 6158 TAACPNSSEVLYT--SAKEELKRFEAFQRQIHERLTQLELINKQYRRL--ARENRTDTAS 6213
TA+ S + + + +L+ +A Q QI + +E + K L AR + +
Sbjct: 2020 TASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2079
Query: 6214 RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWL--TEMDLQLTNV 6271
+++ + + R+++L + V +L+ + + + +L W+ E L+
Sbjct: 2080 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139
Query: 6272 EHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEEL-- 6329
+ + D + + +Q+I + I+ + ++ ++ ++P A ++ ++++L
Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199
Query: 6330 ------HRY------CQEVFGRVSRFHRRLTSCTPGLEDEKEA-SENETDMEDPREIQTD 6376
H++ +E+ +V F LE + +A +E + +D E+
Sbjct: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259
Query: 6377 SWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEE 6436
E E + H + G + + L + T ++ ED
Sbjct: 2260 MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-----LVLEKTNNLSKKFKEMEDTI 2314
Query: 6437 GPYYSALSDVE--------IPENPEAYLKMTTKTLKASS--------GKSISDGHSWHVP 6480
A++ + + ++ ++++K TTK + GKS+ D
Sbjct: 2315 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2374
Query: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNG----- 6535
S PE G ++ + A +TP K K G VLNG
Sbjct: 2375 WSLKTPEIQKVNNSGI-SLCNLISAVTTPAK----------AIAAVKSGGAVLNGEGTAT 2423
Query: 6536 NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIKQNLQQLNSDISAIT 6587
N ++ + GL I + + +E + + EL+ KL LQ+ + SA+
Sbjct: 2424 NTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS---KLQKAQEESSAMM 2480
Query: 6588 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQ-- 6645
WL+K + P+D + ++ +V++ + V + E L+
Sbjct: 2481 QWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN 2540
Query: 6646 TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
++PE+ + L ++ W+ + L +S F + L WL
Sbjct: 2541 PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLV---E 2597
Query: 6706 RRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIE 6764
+ V P DP L R+++ L +E R+PQ + L +L + + +
Sbjct: 2598 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2657
Query: 6765 --AEEKVHVIEKKLKQLREQVS 6784
+E++ + +K L Q+S
Sbjct: 2658 GIVKEQLAAVTQKWDSLTGQLS 2679
Score = 88.6 bits (218), Expect = 2e-16
Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)
Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
++LS G+ +QE++ + L L+ I ++ + I + + +I
Sbjct: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018
Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
+ P++ A + K + ++K+ YE K+ +EM A S KD
Sbjct: 4019 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4078
Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
K V + V +WEN LV E + V+EL +++ + S++ T+ ++ + L
Sbjct: 4079 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4138
Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
+ + +K++ E ++EE + E +D + + L + ++P +K
Sbjct: 4139 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4195
Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
+ + W +N+ +D + L A+ + + + +W + A K+ D E
Sbjct: 4196 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4255
Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
+K++++ +Q SE ++ E++ L +E+ L+ ES L +++ + L
Sbjct: 4256 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4315
Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
+ H L G + + + LD+ + TE LL P ++E +
Sbjct: 4316 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4375
Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
+LQ K L+E+ G L +L L +++++V + +K L
Sbjct: 4376 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435
Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
+K + + ++ W ++ + +L K ET K EQ + E +
Sbjct: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4493
Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
K + + + PK+ + + + + E +E+ R +LE++L +
Sbjct: 4494 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4553
Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
+ ++ WLT E+ P ++ ++F + REQ + +
Sbjct: 4554 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4613
Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
LK F++++++++ L+ R++ ++++L E + F++ ++
Sbjct: 4614 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4671
Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
W++E ++SL + ++ + KIK + E + ++ + L
Sbjct: 4672 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725
Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
+KT L+++ ++WD + + E+ LL ++ + + L L
Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4785
Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
++ + + + + +K F K+ TS ++ LK L+E ++ + S+
Sbjct: 4786 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4845
Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
+ E+ E++ L+ +R+ + + V L L +
Sbjct: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905
Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
P D+ A+ + + +E +L + L K +LA+ T II+
Sbjct: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
+ + K + RLAS AKQE +E L + ++ + K K +P ++ +
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
+ +E T++ V+K+ + ++
Sbjct: 5026 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5052
Score = 58.2 bits (139), Expect = 3e-07
Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)
Query: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4747 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4804
Query: 6613 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6672
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4805 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4864
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6731
S + L +L Q ++FH + LL WLA A+ R + D + R L++ +E M
Sbjct: 4865 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4923
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6779
K+L E++ +++ + +++L H + + + +I + +++
Sbjct: 4924 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4969
Score = 53.5 bits (127), Expect = 7e-06
Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)
Query: 6571 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6627
K+++ +Q Q + A+ W+ +L M+ +D++ ++ +++ L++
Sbjct: 4215 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4272
Query: 6628 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6685
+ + +N ++ L+ TE + +Q L +L L+W++ + + + + L +L+
Sbjct: 4273 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332
Query: 6686 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6743
F LL WL + QK DPKA L + L+ +++ Q V
Sbjct: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4388
Query: 6744 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6797
+ + + N L+ GE+ + K+ V+ ++ + + E+ Q L G A
Sbjct: 4389 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4442
Score = 45.4 bits (106), Expect = 0.002
Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)
Query: 585 LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
L W T+ E L + + K EI+ L L H + +N+AGN L+E S
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
Query: 640 NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
S++ +L LN+RW+ ++ KT+ +KQ L +
Sbjct: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4444
Query: 700 FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
F ++ E+ Q + E+H ++ G + AK E+L +E+ A EAK
Sbjct: 4445 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4493
Query: 759 QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
EE+ K L+ KG M +E + DI N+ +E ++ V + K+
Sbjct: 4494 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4538
Query: 818 EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
E K K++ L++ ++ S ++ +++ +A+Q L P +
Sbjct: 4539 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581
Query: 878 -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
I +HK + S+ + + + K LK + + ++ V ++WE
Sbjct: 4582 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4641
Query: 929 LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
+ VQ+L +E+G+ D+ K KQ ++ KL+ K L E E
Sbjct: 4642 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4691
Query: 986 EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
+ QL H E + L + + R LK+
Sbjct: 4692 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4727
Score = 43.9 bits (102), Expect = 0.006
Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)
Query: 6564 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6623
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2793 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2847
Query: 6624 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6681
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2848 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2906
Query: 6682 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6741
SL + + + + L W+ +N ++ DP +L L+KE+ +
Sbjct: 2907 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2963
Query: 6742 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6801
V++L +NSLL + + +E +I+ K+ + EQ+ L +N
Sbjct: 2964 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 3019
Query: 6802 SFDEV 6806
F EV
Sbjct: 3020 EFQEV 3024
Score = 41.6 bits (96), Expect = 0.028
Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
W+ ++ + ++ + K++ L Q + + WL TE +L KP D + IE
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4368
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
+ + + + +++ V +VN + + +++ + E++ LQ++L L+ W+
Sbjct: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ + L +L Q + FH ++L WL + H+ K L E +E + +
Sbjct: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4482
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6778
E+ + +E SL+ KG +D +EK +E KL +
Sbjct: 4483 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
Query: 6779 LREQVSQDL 6787
+ ++ + L
Sbjct: 4540 RKTKLEEAL 4548
Score = 40.0 bits (92), Expect = 0.080
Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 8/153 (5%)
Query: 6557 RWEMIQAQELHNKLKIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 6613
RW+ + + K ++ L+Q + +I + WL TE L K + + +
Sbjct: 4420 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4479
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGA 6671
L V E+ AF+ + S+ ++ L P+S E + + L WE+ +
Sbjct: 4480 LNVH--MEVCAAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETK 4536
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6704
++ + L ++L +FH Q+ + WL A+
Sbjct: 4537 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4569
Score = 38.9 bits (89), Expect = 0.18
Identities = 45/216 (20%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 6577 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6634
QQ + A +W+ +TE +L L + D +L+V++ EIL+ D LV
Sbjct: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3844
Query: 6635 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6694
S K E ++ +L ++ ++ L ++ F + +
Sbjct: 3845 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
Query: 6695 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6754
L WL ++ + + P + L + + E QL + + E +P +D + + LL
Sbjct: 3902 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3959
Query: 6755 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL 6790
GE +EK + Q++E V + +AL
Sbjct: 3960 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVAL 3994
Score = 37.0 bits (84), Expect = 0.68
Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)
Query: 6558 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6610
W + ++ H++ ++ Q N + D + WL + +L L + ++ Q
Sbjct: 3544 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3603
Query: 6611 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6670
+ ELRV + +L+ + +AL+ + + QT E +Q +L + ++
Sbjct: 3604 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3659
Query: 6671 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6730
L Q+L + H + L WL + K + + + R +
Sbjct: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3717
Query: 6731 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6783
+L+KE + +D L E+S++LL +G + E E+ ++ + Q E++
Sbjct: 3718 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3777
Query: 6784 SQDLMALQ 6791
++ Q
Sbjct: 3778 DAAILRSQ 3785
Score = 36.2 bits (82), Expect = 1.2
Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)
Query: 310 KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
K+++++L K +++ Y ++ ME N + + L ++ + D + ++L+
Sbjct: 4258 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4311
Query: 370 WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
WD L+ +I + KL AL L + AWL E L+ E D +A+ +
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4370
Query: 423 ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
+Q + +S ++ N L+ +E ++L NKLE + +R N+LE
Sbjct: 4371 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4426
Query: 476 K 476
K
Sbjct: 4427 K 4427
Score = 33.5 bits (75), Expect = 7.5
Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)
Query: 6647 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6706
+S + L+ L ++ W+ V L+++L+ C F ++LL W+ +
Sbjct: 3309 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3366
Query: 6707 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6766
A+ P A+ + + +E L++ L +R+ V++++ + D ++
Sbjct: 3367 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3426
Query: 6767 EKVHVIEKKLKQLREQVSQDLMALQG 6792
+++ +++ + + L + L+G
Sbjct: 3427 KQLSLLDSRWEALLNKAETRNRQLEG 3452
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 234 bits (596), Expect = 3e-60
Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)
Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
+N I + + S K LPG +Q S++Q E +QES + +LE++
Sbjct: 1161 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1220
Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
+ K E+ S + N + ++N ED R + +++ PLE D +
Sbjct: 1221 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1278
Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
+ ++ E EKL +LE K + + E ++ + +VL N+
Sbjct: 1279 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1338
Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
S+ ++D L + LK N ++ +++ ++ L E A++ DK +++
Sbjct: 1339 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1387
Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
+ +K++ + +++++ L+ + + +M K E + QL
Sbjct: 1388 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1446
Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
W+ V QI + + + + +DT L Q ++ + +E S
Sbjct: 1447 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1502
Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
L T L K S E++MK+ ++ +K E +K +
Sbjct: 1503 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1555
Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
+Q K R +M+ + +L L + + K D + ++ +S
Sbjct: 1556 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1612
Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
L EE K+ V + S+++ TL+D + K S+++ K E+ S
Sbjct: 1613 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1672
Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
I+ F +QES L+ + +++ + T ++K +
Sbjct: 1673 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1732
Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
Q+E +E GI L + N + E + D +LK + + +Q+ +Q +
Sbjct: 1733 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1790
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
+ +K F L+E + + Q ++ L+ Q++N+ +K E NLK D
Sbjct: 1791 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1844
Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
++ TAIK + Q+ + K + + L+W S +D+ + K K++ I+Q
Sbjct: 1845 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1899
Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
T F+E GK AI + + ++ D + + N L+Q+ +K K
Sbjct: 1900 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1948
Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
++II ++++ + + ++L K L+ EE +KL K ++ + + E + E ++
Sbjct: 1949 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 2005
Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
K + Q++LE + + LQQ L NLE I + + ++F E V
Sbjct: 2006 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 2065
Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
+ ++ +T + + + S+ +V+ KL D L + +
Sbjct: 2066 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 2125
Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
+ N L D + Y++A + + + EA + P VD N + LE Q
Sbjct: 2126 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2185
Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
++ S ++ L + ++ S AK +Q TL ++V + + ++ + + +
Sbjct: 2186 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2245
Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
L + +++ + +E+ L + +PL+ + + ++ L ++ +
Sbjct: 2246 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2304
Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
+ + + ++ + L + L ++ KE EELK + +
Sbjct: 2305 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2361
Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
+ +NL E+L +TK A TE ELS+ + + ++ E+ + +
Sbjct: 2362 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2413
Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
+L +LL + S +P V ++ ++ ++ ++ +++ KE V + ++
Sbjct: 2414 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2466
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
+F + +LK++ ++TT + E + E+ + + +K L I +
Sbjct: 2467 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2526
Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
I + + V PA+ + V+ L + +E +N+ L S S Y
Sbjct: 2527 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2586
Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
++ KI E+N L ++K ++ S ++ Q++ K W
Sbjct: 2587 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2646
Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
EL +K+ EL ++ +++E++P +A W L ++Q+++Q
Sbjct: 2647 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2706
Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
R +L +++ + ++ + + W+ +++ P D L+ VQ+ L+
Sbjct: 2707 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2765
Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
+ + + + LS E L ++E VT + L D
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2825
Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
+ ++ +S+ + +S + L +K + H LE + MK+ I
Sbjct: 2826 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2878
Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
Q K + V Q + L + E + E + L+ ++K + +++ EN Q
Sbjct: 2879 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2932
Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
L + A + MS D L + E + L+ E L+ D K + L
Sbjct: 2933 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2991
Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
H+ ++ + L E + + K N + E +++ES K+
Sbjct: 2992 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 3051
Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
E+ E W + K ++EE + + +NS+A++ SL
Sbjct: 3052 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 3094
Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E + N T E D +D L +V+ TE LH+ K +
Sbjct: 3095 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 3150
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
+ Q+ E Q E+ + L+ K+Q + D+
Sbjct: 3151 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3182
Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
+Q + L+T + +L+ K Q+ L ++ ++D ++ ++S+ + + L
Sbjct: 3183 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3234
Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
++E+I E S+Q D ++ LE K F I ++M+ Q+ + D++
Sbjct: 3235 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3288
Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
++P G++ + Q + + +K +E +++N
Sbjct: 3289 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3325
Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
+ M T+ +L LE L ++ + L + EE K+L E + L +
Sbjct: 3326 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3384
Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
+L+ + E + ET+ +L + ++ L + + W G+
Sbjct: 3385 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3441
Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
+T L D++ + R+ L+ L + +Q+ ++ L ++
Sbjct: 3442 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3501
Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
++ + Q + V Q+Q+ L++ +S V ++ EGE++ +V
Sbjct: 3502 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561
Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
L+ + LDS W L R +L V Q L+ + E + +++L +
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621
Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
+Q AL+ I NH + V+ ++ S++ ++Q++ F
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3679
Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
QV ++I +EKS LQ L + F E+ L L + L +S+ + + E L
Sbjct: 3680 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3738
Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
++ S + ++ +I + + Q L G +L+ + E ++ ++ ++ ++ + K
Sbjct: 3739 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3798
Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
L+ L+ + ++L WL+ + L ++ Q L + +R
Sbjct: 3799 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3855
Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
E KE +L ++ + + LL L L +A+ +++ ++ + E
Sbjct: 3856 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3913
Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
++ + +A +SW+ E + + + + LQ K F ME +
Sbjct: 3914 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3971
Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
+K I D V ++ C E K+ + + + L E Q R ++
Sbjct: 3972 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 4031
Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
N+ + E+L +TE+++ I + L A +TL Q+ E +++L+ + + +
Sbjct: 4032 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 4087
Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
++ L EL ++ Y+ ++ + ED R +DE + + +++
Sbjct: 4088 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4147
Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
Q+ S++ +++ + + EV + + + +K V + +E L+ E L+ +E
Sbjct: 4148 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4203
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
+ G +K A+ +++K W ++ + ++ K +++L
Sbjct: 4204 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4251
Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
+ + H +K + + L + + + + + A + I+E +Q+ +
Sbjct: 4252 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4310
Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
+ S L +P + L SL +A LE+ +
Sbjct: 4311 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4370
Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
F++V L+ G LE++K I ++ +QQ+ E LNH L
Sbjct: 4371 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4426
Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
++ + E S K + D L + W + R +L+G L +F + +
Sbjct: 4427 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4479
Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
+ + L E L P+ +E + + +L+ +V +Q+ ++ L+++
Sbjct: 4480 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4539
Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
+ E + L RWQN ++ QRK +DG +RQ + F +E+L ++LTDT
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599
Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
L A K L E N + F+ + T ++ G+++L +
Sbjct: 4600 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4654
Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
++ + I+ L++ W+ +E +L E + + + E + + I L Q L S
Sbjct: 4655 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4714
Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
L + + + + + K + S + + EL L +DV+++K +
Sbjct: 4715 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4772
Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
+ +WE + R+ R + ++D F+E +L WL + E + +I+ +
Sbjct: 4773 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4832
Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
K Q K+ + + + G L K S ++DD L+++ D+W +
Sbjct: 4833 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4892
Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
R KL+E F Q + L WL R+E +L+ +PV D+ + +
Sbjct: 4893 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4949
Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
+ Q+++ + ++ V+++ L+ S + ++ + L RW +CA+S+
Sbjct: 4950 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 5004
Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
++ ++E R ++F +WL AE+T P+ + L T + + + F
Sbjct: 5005 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 5060
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+++ E+ +L + D+ + +K + R++ + +RL
Sbjct: 5061 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 5120
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
+ E++L WL + LT+ + ++++ L F +E+T
Sbjct: 5121 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5180
Query: 6299 KIDQL 6303
+D++
Sbjct: 5181 DVDKV 5185
Score = 197 bits (500), Expect = 4e-49
Identities = 113/266 (42%), Positives = 148/266 (55%), Gaps = 35/266 (13%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT WIN L + ++DL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 210 ERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 267
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +L+ R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 268 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 318
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S MSA++ LLLW Q+ Y + +F
Sbjct: 319 -------DIHVTGESE----------------DMSAKERLLLWTQQATEGYAGIRCENFT 355
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
+ WR+G F AIIH RPDLIDM +V +SN NL AF +AE ++ + RLL+PEDVDV
Sbjct: 356 TCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPEDVDVS 414
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE 293
PDEKS++TYV+ P GE
Sbjct: 415 SPDEKSVITYVSSLYDAFPKVPEGGE 440
Score = 193 bits (490), Expect = 6e-48
Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)
Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
N EE N FV L+ D +Q ++ + + ++ ++ +A+E+F +SL+
Sbjct: 775 NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 834
Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
AK+ S+ Q+ LT K +H ++ + K+L+ S ++ ER
Sbjct: 835 EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 874
Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
DT + A + I L+E V +++E N + + EL++ NI+
Sbjct: 875 HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 934
Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
VQ ++ L++ + +R + +L + ++H++E F D +E
Sbjct: 935 SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 994
Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
T C + + + LV E +E+ +L+ N T+I
Sbjct: 995 ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 1053
Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
Q S L+ S K R EI I K++ N H K +
Sbjct: 1054 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 1110
Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
+ F PP KEA +D+ + E Y+N+ L LW + N+K+V+ W
Sbjct: 1111 MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 1158
Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
+ + E DR R + E + ++ +Q + E E QV S
Sbjct: 1159 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1210
Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
+ ++E V C + ++L ++ + ES+ L S+ I
Sbjct: 1211 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1255
Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
+LE + ++++Q + + L + +T E +LKK+ E + D T + ++ FS+
Sbjct: 1256 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1314
Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
+ + + N+ + + S T K+K V+ V
Sbjct: 1315 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1355
Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
LK+ + + L K + +L ++ + +E + S + E+++ Q L+D+
Sbjct: 1356 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1413
Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
L+K +E +K +E + + + E++++V Q++N L++ G + +
Sbjct: 1414 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1472
Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
+ +D + +T R++ E + E K L T+ L ++ E+K+S M
Sbjct: 1473 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1526
Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
E + E+ +K+ L A +++ + ++ S A L+ + D+
Sbjct: 1527 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1583
Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
++ + L + Y L +EK L E +K +++ ++L+ + LK ++
Sbjct: 1584 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1643
Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
AG + ++ K+ L +A L L G+ + + +N + L+
Sbjct: 1644 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1701
Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
+ L L+QLQ+S + D V +E+ + DL T +N +E
Sbjct: 1702 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1761
Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
D V+ + K ++LQ+ G+ + + + K+ + G+K+ ++D
Sbjct: 1762 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1814
Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
K+L +E +L AK + C LK+++S ++ +K T+ ++E T++
Sbjct: 1815 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1857
Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
AAV++LEE DW N D E A +K + Q +S EDE
Sbjct: 1858 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1917
Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
N L+ ++D + Q E + + Y +++A+ I Q + T++ ++L
Sbjct: 1918 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1972
Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
G S + + L + + LK + E+ LA E MK + +E L+
Sbjct: 1973 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 2022
Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
D + L + ++ + ++E D + L K E++ +H +T ++
Sbjct: 2023 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 2082
Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
LE+ + +V+ +++Q+K + + N + + L + QH
Sbjct: 2083 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 2142
Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
L L++ E A + D LQ L+GQ Q + K+
Sbjct: 2143 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2202
Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
K +++ ++++ ++E L E ++ + +++ + E +
Sbjct: 2203 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2262
Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
W N+ L +PL + I K + I RQ S+ ++ E+VK + +
Sbjct: 2263 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2322
Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
S L ++DL ++ K + ++E +L+ + F + + E++T +
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2381
Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
V+ + +E H LE L+EI S G+ + + + E+
Sbjct: 2382 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2438
Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
N + F +ED +K K Q + V+ + ++ +K +Q
Sbjct: 2439 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2498
Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
E+ +Q L E+ N G+ + NL +T I V V +
Sbjct: 2499 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2556
Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
G N + + + T + ++ L++KI +L+T + K Q +
Sbjct: 2557 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2613
Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
A+ ++KM + K A + E + L Q + K + L D++ +
Sbjct: 2614 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2673
Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
L EN ++ + K++L E D ++ L + ++ K + N + +T
Sbjct: 2674 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2727
Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
L Q ++ +L +L ++++ + ++ + ++ + +TA I +
Sbjct: 2728 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2787
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
E+ S V+ +L L + R + ++ A T+Y+ + + ++ L
Sbjct: 2788 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2847
Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
+ ++ + D N + LE + ++E++ I Q L E L A +
Sbjct: 2848 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2899
Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
+ +Y EL + + ++FK E +AE ++++ + +++M D + ++T
Sbjct: 2900 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2956
Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
+ S P+S + + LE L + SK L + ++ + + + LL+ + +E
Sbjct: 2957 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 3014
Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
+ L L + W+ K+ +E W C+ +E K
Sbjct: 3015 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 3074
Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
F + E E I L +LQ+E+ + + + + T+E L+
Sbjct: 3075 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 3134
Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
+ E + ++ L + Q+ + Q V + S A E + + S +
Sbjct: 3135 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3194
Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
+LQ QK+ + ++ ++ ++++ + + T+ + Q+H S+Q +E
Sbjct: 3195 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3254
Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
S L+ +G F+N + ++ +++E + A + E +K E I + E
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3314
Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
L +S A M EE + L ++E + +Q +K +++AQ ++++
Sbjct: 3315 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3374
Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
L+ ++SKL E +Q E + Q M+ I P Q QQ
Sbjct: 3375 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3434
Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
++++ R +QL +A + + D L+
Sbjct: 3435 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3494
Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
S +W+ +T L+AN A++ ++ +Q L+D + + + I + E +
Sbjct: 3495 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3551
Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
+ E + + +++LS ++ AL K Q++ ++ ++ + + ++
Sbjct: 3552 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3611
Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
I+ L++ E EE + + + ++I K + + VS L++ +
Sbjct: 3612 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3671
Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
V + + ++ + ++ELL+ + + E+ L LN + S +
Sbjct: 3672 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3731
Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
+ L + Q E+ +++ IL Q + L++ LK T + ++ + E + +
Sbjct: 3732 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3790
Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
R +T VA+ +L RR ++L VE E+ + G+E +A
Sbjct: 3791 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3850
Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
+ P+ K++K + + SS + +E K+ DN ++++ +
Sbjct: 3851 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3910
Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E+ LR Q ++ ++DA+ EK +
Sbjct: 3911 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3947
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
++ L Q + ++ +Q+ +++ + ++ ++ ++ C ++
Sbjct: 3948 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3994
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
E +++ KL V N + + + E++ + + L ++E L P L+E
Sbjct: 3995 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 4048
Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
+SI+++ P + RQ+ + +Q+ EL E K I K PQ + +
Sbjct: 4049 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 4103
Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
+ QE +A S + DV D +S Q DK + L + +L P
Sbjct: 4104 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4163
Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
+ ++ Q+S N + + Y T ++ K +
Sbjct: 4164 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4223
Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
L+ + N+ T E ++ L +K + L +T+ + + LE P +
Sbjct: 4224 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4282
Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
QQ ET+ E+ L L + +L+ A P + ++ + D L
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4340
Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
+ A R L+ + YQ+ ++ ++ + + S + + L + Q
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4400
Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
+ K++AY ++E AE + K+ +E ++ + + + +L+ + DS+
Sbjct: 4401 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4456
Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
+ R +L + Q Q AL + + L + ++K G K + ++A ++
Sbjct: 4457 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4516
Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
N + Q V A LI++ SA S LQN+ ++ V EK+ Q +
Sbjct: 4517 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4572
Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
L L++ + F L++ L L+++ P L E +E+L + + ++
Sbjct: 4573 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4628
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
K + +G+Q++A CP+ ++ I L+E+W S+ K++ +L+ L
Sbjct: 4629 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4686
Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
+ ++ WL ++ TLN SL LDT+ I+ F+ EV +S
Sbjct: 4687 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4739
Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
+ +I + HLK + D ++ L + +W ++ +L + L +
Sbjct: 4740 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4799
Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
+A ++++ W+ E + S + + + ++K L +HKEF+ + K + D N
Sbjct: 4800 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4857
Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
++ L + S + + + L E+ +W + G + LE+ L + + +
Sbjct: 4858 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4915
Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
Q L +WL E +L Q I V L+ + + + +L ++ ++ LK+S L
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4975
Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
G+ D +S + Q+ S+ V L S Q+ L+ + + V + +
Sbjct: 4976 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 5029
Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
+ ++ + L + L++L D+ + E+ + + K + +V I
Sbjct: 5030 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 5088
Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
T K W + +A +++ Q A + A A L + + Q A +++
Sbjct: 5089 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 5148
Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
+ E++P ++++K L + Q E + +D++
Sbjct: 5149 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185
Score = 179 bits (455), Expect = 7e-44
Identities = 674/3683 (18%), Positives = 1386/3683 (37%), Gaps = 526/3683 (14%)
Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
E +LEN+K + E+ ++L + + Q + L L+Y E L RLE A L++T
Sbjct: 813 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 869
Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
+ L R T +W E A +W + ++ K
Sbjct: 870 RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 918
Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
E+ RE LD +E + + + E E L + Y ++ Q + L Q
Sbjct: 919 HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 974
Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
+ Q++ E++ E +E T +Q+ + K ++LVQ ++E+
Sbjct: 975 VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 1032
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
+ + N + T Q P S+ K + + I + +I+
Sbjct: 1033 EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 1080
Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
TI + +A + NE + S + + N ++
Sbjct: 1081 I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 1132
Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
++Q+ +N+ + WH +NE+D S V I PG+ Q+ + NL
Sbjct: 1133 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1192
Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
F+ + + SQ ++ + +QL K V + Y +LLKS E + S ++ +
Sbjct: 1193 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1252
Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
+R L + + + ++ +L S+F E + E + L + ++N+
Sbjct: 1253 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1312
Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
Q S+P ++ + V+ ++V SM + K+KT+ L + E E
Sbjct: 1313 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1372
Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
L E ++ + ++ I+ + ++ E+ + VF LQ K + +
Sbjct: 1373 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1422
Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
E+ K ++ ++D E Q++ + H+ D ++L L+G I + K
Sbjct: 1423 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1473
Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
+D + ++ T + +++ Q + + ++ V+E + + K++
Sbjct: 1474 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1529
Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
++ + Y A V++ E++ + ++ ++ P ++ R SS+ I+
Sbjct: 1530 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1575
Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
QE + + T ++ ++T DSL + E SL +
Sbjct: 1576 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1634
Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
E+ PP + S + E E T E E+
Sbjct: 1635 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1694
Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
KT L ++ +V VE E + A+ QQ +++L G +LT+ E
Sbjct: 1695 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1753
Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
H+ AF++ E K Q + Q + + + L V N E EK S
Sbjct: 1754 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1811
Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
++ I +K +E + + + +NL EL+ +VT + +K +Q+ E K
Sbjct: 1812 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1869
Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
+ D++ ++ ++++ ++ Q N T + A E++V N
Sbjct: 1870 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1919
Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
G+ L+E V +G TTQ E+L
Sbjct: 1920 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1938
Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
Q+ ++ Q +++ + + + ++ L S EE ++ + +E +V
Sbjct: 1939 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1994
Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
HYET LA S+KK L ++ LE FD EH + +
Sbjct: 1995 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 2039
Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
+L+AG D ++KR +I K L+ ISG V A+ K D V
Sbjct: 2040 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 2097
Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
+ V + D +R Y+ + L+D++D Y + S +
Sbjct: 2098 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 2152
Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Q + + + E + + + L L++TK ALQ QI + +V +KL ++
Sbjct: 2153 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2208
Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
+LP+ ++T + V + L + + KLQ L + + + +
Sbjct: 2209 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2267
Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
+ S+L V L + IS ++++I G+ + + + K+ + + +
Sbjct: 2268 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2327
Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
L+ ++ L ++ + K L +++ L + + S++L +LE+ L
Sbjct: 2328 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2387
Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
+V++ ++ + + F E K ++ SL + S H +D A +
Sbjct: 2388 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2441
Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
+K+ + + + +E + Q + + + + SW+ +T+ + + PS A
Sbjct: 2442 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2497
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
+ L+ K+ + + K + VN S + L + + E
Sbjct: 2498 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2557
Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
EF + G +++ + + +L KI L L + +++ + +
Sbjct: 2558 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2617
Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
WL+ + Q+ P +V+ + + E +L + ELK L
Sbjct: 2618 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2677
Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
++ P + + ID +Q+ R L + + T Q+V L++W + +
Sbjct: 2678 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2737
Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
L V P+ + L Q + +Q L E + + +E+L Q +
Sbjct: 2738 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2784
Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
+ + G PS+ I++E+ ++W + ++D+ + Y + + +
Sbjct: 2785 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2843
Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
L + K +S + + + L A + +E+Q + ++ K +A ++ S L + +
Sbjct: 2844 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2902
Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
++ L G L S Q+A +++ + A+ +F +DF L++ K
Sbjct: 2903 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2958
Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
EE+N LD L K++ D LTAQS E + LK S
Sbjct: 2959 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 3012
Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
+ A LQ + W ER ++L+ EK L E+ WI +
Sbjct: 3013 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 3070
Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
E +K + NS+ +L QK V + A+S LL EI+
Sbjct: 3071 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 3121
Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
E +T+ +K L + + + +K ++ + +++++F + R L L
Sbjct: 3122 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3181
Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
++ Q + Y T + + + K + + + A L A + ++ +D K V ++
Sbjct: 3182 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3237
Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
+ + Q+ E ++ ++ + I+E+ S+ + S P+ E
Sbjct: 3238 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3297
Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
L +KE IK + L A N +T K L D++ +K +E L +Q L
Sbjct: 3298 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3357
Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
R R++++E + F K KE L + E + +E M +
Sbjct: 3358 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3417
Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
QK EEI + + +G LI+++ KS + + ++ L+ +N RW+ L +
Sbjct: 3418 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3474
Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
R +L+E + + +L +W+ E EL + + ++ ++ EQ+ LQR
Sbjct: 3475 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3533
Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
++ + VE V+ + + A E D ++ + LD RW + + R
Sbjct: 3534 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3586
Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
++E + Q+F + +WL + E+ + +E++ + +A + I
Sbjct: 3587 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3646
Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
++ L Q I + + L+ RE++ S+L + +Q W +Q + + L+
Sbjct: 3647 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3701
Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
+ F ++ WL E+ +L+ +V+ +S + +L Q++I L +DQ
Sbjct: 3702 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3761
Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
++ G +L++++ + ++I+D+LE + +++ + + RRL S
Sbjct: 3762 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3821
Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
CT + E E ET + P+E++ ++ + + + S +
Sbjct: 3822 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3881
Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLK 6457
P R G E V+ D+ + D E D + L + + +A L
Sbjct: 3882 VPWRAREGLEKMVAEDN--ERYRLVSDTITQKVEEIDA-----AILRSQQFDQAADAELS 3934
Query: 6458 MTTKTLKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKL 6517
T+T K K +S G ++E D+ + + + K
Sbjct: 3935 WITETEK----KLMSLGDI---------------RLEQDQTSAQLQVQKTFTMEILRHKD 3975
Query: 6518 LLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQ 6577
++ D K G +++ ++E + ++ +D I ++ + + +
Sbjct: 3976 II---DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 4032
Query: 6578 QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVN 6637
Q + WL +T++ + L P + + + + + +++ + +K + +N
Sbjct: 4033 QFWETYEELWPWLTETQSIISQL--PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 4090
Query: 6638 VSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLL 6697
+ + L+ E +Q + L+ + V L +++ Q FH +L
Sbjct: 4091 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4150
Query: 6698 LWLASAKNR-RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 6756
L R RQ ++ A+ + E E + ++ + QP + L++ ++ +
Sbjct: 4151 ESLERIVERLRQPPSIS---AEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4207
Query: 6757 GHGEDCIEAEEKVHVIEKKLKQL 6779
G D + ++ KL Q+
Sbjct: 4208 SGGTD---KDISAKAVQDKLDQM 4227
Score = 174 bits (440), Expect = 4e-42
Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)
Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
LQ Q E K F +KL A ++ + K +L ET + V + LE S+QC
Sbjct: 3299 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3355
Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
LL + + +E K LE S L S+ L+++ +++ + +G +
Sbjct: 3356 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3405
Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
+ Q LN +GKQ S S LE + + +W
Sbjct: 3406 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3465
Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
+LNKK+ +LQ L H + + L W+ ++ + K S + ++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3521
Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
+ I + +D++ S + G ++ E D + L+ + +W L+ +
Sbjct: 3522 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3581
Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
+L + + + + + W+ +E + + + + + AS+++ + +HK
Sbjct: 3582 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3639
Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
++ ++ + + V+ QSL LS+ + + + +F++ W+ + +
Sbjct: 3640 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3692
Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
+ + L+Q L + E++++++N WL ++L L Q+ E + +
Sbjct: 3693 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3751
Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
+LL Q+++ L L+ LKQ+ V +++D I ++ + + T V +
Sbjct: 3752 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804
Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
L+ ++Q + +++L ++ + + + + V+ E + Q+ + L+ E
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3860
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
A++++ + L EV L L P A E +E+ ++R+ V+ I ++++ + +
Sbjct: 3861 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3920
Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
+ + A + + + E K L +I + QD Q VQKT
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3968
Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
L++ ++D L + S H ++ S + ++K L ++ + + +
Sbjct: 3969 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 4022
Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
+LE + L+ E + L E S ++ + A + + E +L
Sbjct: 4023 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 4081
Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
K + MN+ T L S +G + EK++ + Q+ E + +EA+
Sbjct: 4082 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 4136
Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
K+D + SL ++E+ + + AEV I + I++ S + LQ L T
Sbjct: 4137 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4196
Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
++ R E + S TD+ +A + + +D +V W++ T VE
Sbjct: 4197 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4251
Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
+F D L+ +K + F S+ + + E +EI + +
Sbjct: 4252 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4311
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
L G +L+ K V + I +L +W + + I + + ++ Q + ++
Sbjct: 4312 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4369
Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
+ + + + P + DL K+ I+EL+Q + Q E++ + +A+L
Sbjct: 4370 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4428
Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
+ E D +++ + L W+ L R+ R+ ++E L F EL AWL
Sbjct: 4429 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4488
Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
E + + + + IE + ++ L ++ ++ + + G+ LI++S A+ +
Sbjct: 4489 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4548
Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
+KL +N RWQ++ + R ++L + + +L+ WL E L SKP+
Sbjct: 4549 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4607
Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
+ + EQ ++ ++ A E+ ++ C E + I Q
Sbjct: 4608 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4660
Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
+L +W ++ ER+ K+EE L +F + F +WL AE+T + ++
Sbjct: 4661 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4720
Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
+ ++ + F +++ Q+ ++K L ++ +K ++ RW+ +
Sbjct: 4721 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4780
Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
+R+ R L + ++F ++ WL E + L + +E ++ D ++ Q
Sbjct: 4781 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4840
Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
FQ+ + + D G L +K+ D L ++D L EL + G+
Sbjct: 4841 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4893
Score = 160 bits (404), Expect = 5e-38
Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)
Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
LT S LS G T+ L + A T G+ + + P+ SL+ KL +I++
Sbjct: 708 LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 765
Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
+L K S++ L E +I L + E++ Q + SDL + + S L++H
Sbjct: 766 LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 819
Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
KN + + +LKE + SE + + KL LE + +K+
Sbjct: 820 ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 869
Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
++ ++HL H +S + L + E + A + + + R +D H L +
Sbjct: 870 RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 925
Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
L +EE K ++E E+ L +A A + Q+ + QL ++++ +
Sbjct: 926 LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 985
Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
E EAT + + +++ + + ED Q + +++ + I
Sbjct: 986 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 1045
Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
++++ L PL E I K E +L A+ + I
Sbjct: 1046 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 1105
Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
+ P V K D++N Q+ N L L + SH + YL ++
Sbjct: 1106 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 1163
Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
D +R + K G +H Q + ++ FL+ +Q D+T L KE+
Sbjct: 1164 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1219
Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
Y E K+ E+ L +++ + L++Q++ ++ D H
Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1279
Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
+ E + + + L T+ N +EF S + + +L + + N++
Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339
Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
T L V +NT + + + K + E + + K +E + S
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1392
Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
LK RS EK+ F E Q + + ++ L+ DW K D VE +
Sbjct: 1393 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1452
Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ ++ + +S+K D +++ Q ++ Q E + L TQL +
Sbjct: 1453 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1512
Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
K + +E EC E + L + Y A +D+ ++ + ++ + S
Sbjct: 1513 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1571
Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
++++F + Y+ S+K L +++SL+ + V +++K++
Sbjct: 1572 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1631
Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
++I K K KI E +S + + L Q+ +HG + +++ +
Sbjct: 1632 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1690
Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
+ +QV E F+ + ++Q+++ S ++ +++ + R + +E+ +
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750
Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
T+ + H + + G +++K+ ++E+ KN E N LK+
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1807
Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
E L E L+L+AE K+ D + +KE + A L E
Sbjct: 1808 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1867
Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
I L D ++ + H ++ + ++ EE + L T
Sbjct: 1868 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1927
Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
+ T E+L QYQ + V+ +TQ +Q L LE++ + + K +
Sbjct: 1928 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1984
Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
L E + A +E ++K H + Q+EL++ D+ + L +EL
Sbjct: 1985 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 2040
Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
E D + L + R + F ++ + HK R + + E A S + +
Sbjct: 2041 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 2094
Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
+ ++ V+ ++ + DR ++ KC +L LK + D D S L LQ
Sbjct: 2095 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 2153
Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
K L E I K L EE Q +S + ++KK EV+L A S
Sbjct: 2154 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2211
Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
+L + + K L D+I+ + + + EK + + + D L ++L
Sbjct: 2212 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2262
Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
M +E S KE L+ QD + ++ + I + +N ++K D
Sbjct: 2263 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2322
Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
A Q + S + A K +E ++ +++TK+ FE+L +L T ++ +T L
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2381
Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
+ L++Y +E+ + +E LE + ++ G P + + L K
Sbjct: 2382 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2440
Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
L ++D + EK ++S + +L L+ ++E K ++ +F A++
Sbjct: 2441 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2500
Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
+ LE+ K K++E +++ V +S S + +A+ ++ A+++
Sbjct: 2501 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2555
Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
+T E + L ++ T E+ G+ L ++ L K L +A +E
Sbjct: 2556 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2615
Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
W +++ + +W+ + EA+ Q + E + +EL + L L
Sbjct: 2616 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2675
Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
+ + K Q L L + R + ++ + +TV A ++
Sbjct: 2676 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2735
Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
KE +L + + ++ T+ Q+ +E K ++Q T + Q + + + S +
Sbjct: 2736 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2795
Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
E+L ++ +K + + R + + + + +S + L D+D K+S+
Sbjct: 2796 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2853
Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
+ S+ AM +++E +++ +QQ+ K I+ AQ + + + + + K EL
Sbjct: 2854 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2908
Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
+++ I VEQ + + + Q+QQ+S+ + + + NK+ +
Sbjct: 2909 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2968
Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
K++ L+K E I +LL + L T+ +
Sbjct: 2969 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 3028
Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
T ++ AL+ EQ L + +LE++ + E SI +
Sbjct: 3029 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 3088
Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
L + + Q ++E L V I+ EV KS+ ++V + L SK+
Sbjct: 3089 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 3148
Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
+ ++ + EV E+ R ++ ++ L + QT K L +
Sbjct: 3149 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3208
Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
+L QD+ + +E + QE + L + V ++ + + +++ +
Sbjct: 3209 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3268
Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
N FS D+ D + + + E ++KQ I + ++ E L+
Sbjct: 3269 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3328
Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
L E+ G++RD L A++ + + +R A R+ G++ L +++E S
Sbjct: 3329 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3386
Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
+ +KAE +S + ME + TI Q+ +M ++
Sbjct: 3387 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3421
Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
+ + QG + + + + +T +E D D + L +V + + E
Sbjct: 3422 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3481
Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
L C V EL Q + E + + A +Q Q L Q+L+ +
Sbjct: 3482 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3541
Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
E+ K+A E K + L EAL K +T LE + ++ Q+ H
Sbjct: 3542 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3599
Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
E L+P+N L+ +E + Q ++Q+ + K +E D
Sbjct: 3600 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3642
Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
I + +H + + SS E+ D+ S L D Q +
Sbjct: 3643 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3683
Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
E+ K L + + + V + N+ L ++ + S L
Sbjct: 3684 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3729
Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
Q+ TE L K+ EL + L +V++ L + +G +V L
Sbjct: 3730 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3785
Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
E +K Y ++ D+ K + + L + L L+ + + + G
Sbjct: 3786 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3845
Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
+ +++ Q K L + K+ +L SLNE+S + +A E E VA
Sbjct: 3846 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3895
Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
++ ER L + Q+V +++ + +A ELS ++TE+++ + G + L
Sbjct: 3896 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3952
Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
+ QT +++ +Q +I HK LV + ++ A S + S+ +
Sbjct: 3953 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 4001
Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
+ T +I E+ Q + Q WE ++E + L + + +IS LP+ +L
Sbjct: 4002 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 4060
Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
ET + E ++Q++ I + + G QL+ EL G+ ++E++
Sbjct: 4061 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 4111
Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
++ L +I ++ + L +S + D++ + LES + + + Q ++S ++
Sbjct: 4112 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 4170
Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
+ I+ I+ S ++++ L + G +++ + A Q + +
Sbjct: 4171 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4224
Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
Q+ I E +H L E+ + E+ W +++ + +D+ + P S
Sbjct: 4225 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4284
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
VK + + R E+D Q +D V N ++ C K + + + E+N W
Sbjct: 4285 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4340
Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
++ +I LE+ +++ + ++ +Q + +W++ +L ++ + + K
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4396
Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
Q IE KS+A + + L A LL+ D EL S+
Sbjct: 4397 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4454
Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
++ + ++ L + DE+ + KPV + + ++
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4514
Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
LQ++ + + + E + + L + A ++ K + ++RW V + + Q+
Sbjct: 4515 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4574
Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
L+ K + HGE L+Q + + LA+ + G E L ++ +
Sbjct: 4575 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4630
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
+ K + +L R P+ AE++ + +++L +R LE+ L
Sbjct: 4631 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4686
Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
+ A EF L F ++ + E + LD + Q E+ F N V + Q
Sbjct: 4687 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4744
Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
+++ HL S K + V +K L ++ +W + +ER L K +
Sbjct: 4745 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4802
Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
E W +L+E +EE+ K +++AN ++ Q +K + + ++ D+
Sbjct: 4803 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860
Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
L + T + ++ + S+L D+W +R+ ++ + FT +++ L
Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4920
Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
+L L+ E ++ L+ L + FQ+ +RT+ L+ + L+
Sbjct: 4921 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4975
Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
V ++ +L W+ + + +L ++Q F S V + + E
Sbjct: 4976 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 5034
Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
R + ED L L + KE +K+LE+ A L + TM +
Sbjct: 5035 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 5087
Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
+ + +K I + ++E++ +Q + L + E + L AWL E +
Sbjct: 5088 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 5147
Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
I + IE++ K + E F E ++ KQ + + K RAA+
Sbjct: 5148 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5195
Score = 155 bits (393), Expect = 1e-36
Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)
Query: 616 ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
++L + E +L E VE + ++ S+ISK L+ K + SK ++
Sbjct: 1601 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1660
Query: 669 ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
+ L + K D N L K+ K E FS + +
Sbjct: 1661 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1720
Query: 714 QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
++K EK E + E+ +L+ D+ +LIG E + ++ + E
Sbjct: 1721 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1779
Query: 768 ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
E K + E++ +E+ L+ + + +S ++ ++ K+ EAK K +
Sbjct: 1780 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1833
Query: 828 VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
+K + K L V + + ++EES+ ++E+ + + E G +
Sbjct: 1834 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1890
Query: 880 KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
KHK+ + + T K+ +E+ N+ E D+ + ++ +++ + +
Sbjct: 1891 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1950
Query: 935 LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
+ Q + I + + +L+ + Q ++ E+K + K L +E +E +L
Sbjct: 1951 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 2010
Query: 994 HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
H ++ EEL E + L+ EQ++E L A +I+ + S +E
Sbjct: 2011 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 2064
Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
I T S NR + +K D A ++ L +
Sbjct: 2065 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 2122
Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
++ L+++Y Y D L LQ + + S LQ +L + +
Sbjct: 2123 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2182
Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
++ + ++ E + E + NDI+K D + R +L ++
Sbjct: 2183 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2237
Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
N R E L+ L L V+ S L +PL+ A+Q D I
Sbjct: 2238 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2290
Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
+++ QD +Q I N + E ++ P ++Q + +F +H+
Sbjct: 2291 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2349
Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
V+ E+ + L+ FL + L + + VT+LS + E
Sbjct: 2350 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2409
Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
K+ E L+K+ + H DK L + L FK+ E + TSC+ LDAF
Sbjct: 2410 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2469
Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
+ + + +E T++ +++ F +L K+++D + K LK P + V +
Sbjct: 2470 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2526
Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
SL L + + ++ N+ + + ++ + + +
Sbjct: 2527 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2586
Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
E+ L+ + + + L L++ Q S + +QK + + + +
Sbjct: 2587 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2646
Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
+E K E + V+K+ ++ L L + E P K+ +D +W ++N+ T
Sbjct: 2647 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2706
Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
D + L + + ++ + +W EK L L L+ D L + Q +
Sbjct: 2707 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2765
Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
EF+ R + + L + + L + S+ ++ +T + + +L+G ++ + +
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2823
Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
DQA + +SLL++LS S SL + T +EIQQ+
Sbjct: 2824 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2883
Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
Q K + L E+ + E +EL +Q E + F + ++H L
Sbjct: 2884 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2943
Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
++F W K + S +E ++ DF TL ++ ++ + +
Sbjct: 2944 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 3003
Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
++ + L L + + + R +L++SL++ L+ ++ L W+
Sbjct: 3004 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 3063
Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
N E+ K +P GE + ++L ++ +Q F V LNN+ KE
Sbjct: 3064 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 3123
Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
E + +I + + ++ + ++ E+ +E K
Sbjct: 3124 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3183
Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
+L T+ +S L H V K + + L+V E K
Sbjct: 3184 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3232
Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
+LL+ E A+ + + Q + ++ L I + + + S + ++L
Sbjct: 3233 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3292
Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
+ E + KE ++ L +L+ AL K+ + + DL + +
Sbjct: 3293 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3345
Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
+L++ Q N LL+ + + E+ IK L E S L++ +Q + EH+ Q
Sbjct: 3346 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3399
Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
V T++ F F + + E LQ Q+ N L L +S
Sbjct: 3400 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3444
Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
++TS+ G + DD+ + + K + R A ++ + C L S+L TE
Sbjct: 3445 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3504
Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
+ L +K +++ V+ QE +++L +D E+ K ++A + +
Sbjct: 3505 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559
Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
+ + Q S+ ++ E +N E +N+ LE +++ NE L IEK
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3619
Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
E LE+ +K ++ HN IG S + L + + K S
Sbjct: 3620 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3679
Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
Q + + QE + ++ L + + ++ + +L+++ ++ + + S L
Sbjct: 3680 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3738
Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
W+ S V D L + + Q L +G E ++Q IQ K Y +
Sbjct: 3739 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3795
Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
T L V T +Q L RL S E +++ + VLKG
Sbjct: 3796 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3848
Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
QA+++ K + E K K L D +N + W E L + AE+ ++ I
Sbjct: 3849 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3908
Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
K++E + W +L I L D +Q++ K
Sbjct: 3909 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3968
Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
IL + ++ L + + + + E + L+ + Y + +++R QLE
Sbjct: 3969 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 4028
Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
+ F+ + + E+++ II ++ A E E TL Q+E +++ I+
Sbjct: 4029 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 4081
Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
H + + + EL+ E ++++ ++I+ ++ ++ I Q
Sbjct: 4082 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 4141
Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
FH+K + E S++R L Q + + E+ +K++++ K + + KL+ +++
Sbjct: 4142 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4196
Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
+ G + D S +LDQ+ T V E+E +L + ++ + F
Sbjct: 4197 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4256
Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
+H + + DL+ + V+K + E+ R L + ++ L E
Sbjct: 4257 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4316
Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
+I E D +K I ++ D L K ++ + +L QD L+
Sbjct: 4317 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4370
Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
++ +L I +++ ++ + + EA+Q+Q+ E + +A ++K
Sbjct: 4371 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4430
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
EE S+ V+ L E + + L I R + L A L +++ A+ + +T
Sbjct: 4431 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4488
Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
E ++ + VG +++E+ L K L++ V Q E + S+ E
Sbjct: 4489 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4547
Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
LQ L+ L + + E + ++ + + L K + ED+ L+ E L + +
Sbjct: 4548 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4607
Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
LP + +E L +E A + + K + K +Q+L RC ++ + + ++
Sbjct: 4608 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4663
Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
L EKW S+ E + EE W +E+ R ++ILD +
Sbjct: 4664 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4723
Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
++ E + + + E++ EL L Q + V + LL+++ + + +Q
Sbjct: 4724 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4783
Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
+ E +++ A+ ++ E K L ++ + + ++T++ + F
Sbjct: 4784 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4843
Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
K + A + + T + +++ + D+ + + EL Q+ L++
Sbjct: 4844 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4903
Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
L + L+ +Y + P E Q + L D + E+ K + S
Sbjct: 4904 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4963
Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
A++R E+ G + V+ +Q+ S E + L+ + E S V
Sbjct: 4964 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 5023
Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
++E + G + D L Q+++ ++ E + ++LNKAT +
Sbjct: 5024 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 5083
Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+ D + + + WI + + L H + AL K LL ++
Sbjct: 5084 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 5138
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
L+ TD+ + I + +V AL Q ME + + Q D V
Sbjct: 5139 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185
Score = 155 bits (392), Expect = 1e-36
Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)
Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
+L L+S+ ++L + ++ FS +++ Q Q+ +++ + +E Y +
Sbjct: 1186 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1245
Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
++++ N + D+ + QI + L E R++ Q+ K++ L
Sbjct: 1246 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1297
Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
KDD+ ++ +C++ + +S+ + LN +L++
Sbjct: 1298 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1345
Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
+ + + + V ++TQ + A+ KL E +++ + + + ++ + ++ DE+
Sbjct: 1346 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1403
Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
+ +ELQ D M + + +++ + K+ A + +E+ + ++
Sbjct: 1404 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1454
Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
+DN L+ L + K+ + +++ VE++ + + +E+
Sbjct: 1455 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1500
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
T L++ K ++ IE ++ + + E S V D + + +++SQ K
Sbjct: 1501 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1560
Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
+ I +++ Y TLM + D+ L+++++ L+ K
Sbjct: 1561 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1620
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
E+A +LQ S AE K + K+K + E+ ++ E L
Sbjct: 1621 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1670
Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
+ + L K + RN++++ + L S LL + L Q+++ + + D
Sbjct: 1671 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1722
Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
+ ++ V +E K+K+ LT E + + + + + K + ++L+
Sbjct: 1723 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1782
Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
++ + A + K + + QE + LI E EA++K + L+A Q
Sbjct: 1783 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1838
Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
+ +E+D ++T ++E T E++ QL+ K + + ++ N + E
Sbjct: 1839 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1888
Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
+Q E+ +E D N LL +V+ V NL + +K
Sbjct: 1889 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1948
Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
+++ + + Q Q E++++L++ +K+L E AL
Sbjct: 1949 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 2003
Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
+ + L E+ D + L Q Q +E + D+I + KL K+F
Sbjct: 2004 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 2061
Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
+ + + + D Y + N VLE + ++D +++ L
Sbjct: 2062 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 2111
Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
H ++ +S + ++ +K + ++ + E + A + + +A TA + E + +
Sbjct: 2112 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 2170
Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
+++ +L E + LQ Q+++ + VL DA +L K + + ++ I
Sbjct: 2171 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2226
Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
VG E+ + + E+L+ T+ +QD L E L + + E+ L+ Q
Sbjct: 2227 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277
Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
LQ+++SKN +++ +++ E K + + + ++L L
Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337
Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
S ++E L ++E+ K V + E KL+ L TE D G + ++
Sbjct: 2338 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2394
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
+ E LE K E+ LK+ S + + A++L+ NL ++ E+ T
Sbjct: 2395 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2451
Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
KEA T+ CQ E ++ Q+L+ L I+ + VP
Sbjct: 2452 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2490
Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
Q ++ K L+ +K +E + E I+L N TT + +A
Sbjct: 2491 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2549
Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
+ +E+F KG + + M + Y ++ ++ AE+ +++
Sbjct: 2550 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2604
Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
+ +KA E+ +K++ K + A E + + + + +N+ K
Sbjct: 2605 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2663
Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
QE++ K+ + L+ W L E+DS+ Q++ + D Q E N + FQ
Sbjct: 2664 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2723
Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
Q +Q E S Q + + ++E++ E
Sbjct: 2724 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2783
Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+L+ P + SLR LS + A+ S Q +LL S+
Sbjct: 2784 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2843
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
L DL + + + NQ QK+ + + Q Q + +D+ A+ E
Sbjct: 2844 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2903
Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
+ +++ IL S + + E H++H + + ++ + ++ + Q
Sbjct: 2904 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2963
Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
P+ + +LE++ ++ + K + Q++ +++ I + +L
Sbjct: 2964 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 3006
Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
L+ ++A +L ++ + KQ+ N+ KE L + K V L + +
Sbjct: 3007 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 3066
Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
Q +E + +E E +A+ + ++++ N S+ + +++EV
Sbjct: 3067 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 3126
Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
KS D E+ ++ + K+ +E S S +Q A ++ D+
Sbjct: 3127 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3184
Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
+Q + L Q + SL+ + + + D +++SD++G + +VE E
Sbjct: 3185 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3244
Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
+ + + + LE LQ N E + A+ + L++Q
Sbjct: 3245 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3304
Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
+A L ++E +A +TCK ++ D + + EALS + L +
Sbjct: 3305 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3364
Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
E+V+ L+E +S+ + +IL + +E EH+E+ PV + E E+I Q + K F
Sbjct: 3365 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3419
Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
Q++++ L+ +Q +++ I+ AK Q +HD D T + A A
Sbjct: 3420 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3479
Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
E D +S+LS W EL + K P L
Sbjct: 3480 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3531
Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
+L++ + ST + IL +++ + R+ + +T QLE +
Sbjct: 3532 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3591
Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
A E ++K+L +Q S +EE + + +D H
Sbjct: 3592 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3649
Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
L+ A+S G LK ++ E+ +++ D QV Q + RS+ L
Sbjct: 3650 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3697
Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
+ L + + + L + L + L + S+ + S + + +Q + ++ +
Sbjct: 3698 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3757
Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
V + G L L EV ++D L++ ++ARY +++ S V ++ + AL
Sbjct: 3758 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3812
Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
L E L K+ E L++ + K + A QAQ+ +N+K L
Sbjct: 3813 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3871
Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
V+ LL +++P W + K++ E + + + ++ QK EE D
Sbjct: 3872 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3916
Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
A++ + + + +S + ETE++L+ ++ S Q+++ + R
Sbjct: 3917 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3973
Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
+++ G +++ + S E + KL+ + +N + +L R Q+L+
Sbjct: 3974 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 4033
Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
+ ++L WL +Q ++ +L + +T+R + + + E
Sbjct: 4034 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 4086
Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
+ G QLL L + +++ + ++ + + L + + I
Sbjct: 4087 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 4146
Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
+++ + + + S+ + ++K + ++K ++M+ Q + + + Q ++
Sbjct: 4147 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204
Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
+ D+ +K + + L +M W +H ++ + L ++E +
Sbjct: 4205 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4259
Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
L ++ ++ ++ L+ P SV K Q+ + + L E + L S
Sbjct: 4260 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4316
Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
+ + IDEL S+ ++++L+ +MQ+ +Q ++D V+
Sbjct: 4317 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4376
Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
+ + + P+ LET++ Q+E L+ + EA + E+L L K
Sbjct: 4377 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4432
Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
S +++ W + + I ++ K + L + +A E A L E
Sbjct: 4433 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4492
Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
+ + G+ A + A + LQ+DV Q T EA + + L E+S
Sbjct: 4493 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4547
Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
L L L QR + + + + + L Q K F +E L+ + E +L
Sbjct: 4548 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4605
Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
L + KE + + A A+ + L ++ + P S + + N+
Sbjct: 4606 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4665
Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
+W ER ++L+ + L +F + +I L + E+ L V S P L+
Sbjct: 4666 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4722
Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
+++ E +V N+ +S+ Q ++L T T ++ ++ + + L RW+
Sbjct: 4723 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4780
Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
VQ + +R +D ++ + F + L +L ++ L S ++ +T+ H+
Sbjct: 4781 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4840
Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
K + + + T G L T L + +S+L+D W + + E
Sbjct: 4841 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898
Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
+ + + Q ++ L L ++ Q + P +H D+ LI K ++ L
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4957
Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
T +++ L+ +L +D +K Q++ L +WE +C ++ +E L
Sbjct: 4958 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 5016
Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
F+ L WL + E VL + ++ +I++ K+ M+++ +
Sbjct: 5017 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 5075
Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
MGD ++ + I + I R++ + ++L A + + + L
Sbjct: 5076 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 5135
Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
WL E+ L+ K V+ + +E++ +AE Q ++ + V+ V
Sbjct: 5136 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5193
Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
D + ++T+ ++ L +W+ + +++E
Sbjct: 5194 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5253
Query: 6127 RRMKIEE 6133
RR K+ +
Sbjct: 5254 RRRKLND 5260
Score = 146 bits (369), Expect = 6e-34
Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)
Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
P+ +AM P++ F++ P +E++ +E+ Y + E + + ++ H+L
Sbjct: 1105 PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 1160
Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
N RI S+ +S + Q L++LQ + +E ++ S +LE VN
Sbjct: 1161 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1220
Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
K+ + ++ LK ERE Q + R+E+ E L ++ P+E+
Sbjct: 1221 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1276
Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
L H+ F + + +++ + L ++D + I N+ EE +
Sbjct: 1277 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1321
Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
L + N++L+ Q M+ D LK + L + + A+ + T L +
Sbjct: 1322 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1378
Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
+A +N + T+K E+ H ++D KAK + K K D+ F
Sbjct: 1379 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1438
Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
+ D E N+ +L + G G ++ + L+ I + + IQ+ Q
Sbjct: 1439 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1498
Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
+ SK T+ +++K L+ ++ + +E +++ ++ + ++ KD +T+
Sbjct: 1499 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1549
Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
+ ++ K+ V Q L +++++ + ++ T L+ + Q
Sbjct: 1550 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1599
Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
++LK+ E + ++EE EH+E ++ + N+ L + +PPF K+
Sbjct: 1600 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1653
Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
+E+ E L AL I + K KM T+E+R L++++
Sbjct: 1654 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1696
Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
+ + E FS + ++Q S ++ +E +++ I + + + L
Sbjct: 1697 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1756
Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
G + T EL+ + + K G ++L + + +++ E KL + +
Sbjct: 1757 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1816
Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
+++QK L E +I C L + + KK+ + V +++ +L + K
Sbjct: 1817 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1872
Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
N DW SN+ + + F+ + K ++ ++ + + L
Sbjct: 1873 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1932
Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
T E N + ++V + ++ + + +++ GQ E+ E + Q KE
Sbjct: 1933 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1991
Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
L+ SLQ+ L D D+ WL E++ + +E +
Sbjct: 1992 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 2051
Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
L R++ E V L+ + + +C
Sbjct: 2052 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 2111
Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
DR+++L + + + K L + Q + D +A D
Sbjct: 2112 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2171
Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
+ ++++E+ + + E+++K E++L DAR + + + +Q
Sbjct: 2172 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2220
Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
KTL DI ++++ L+ + EKL + + L ++ L ML +E K++
Sbjct: 2221 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277
Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
L A I K + QD+ +S N + E K + +P
Sbjct: 2278 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2323
Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
SL +++D +H + +L T + +N S++ +F + +
Sbjct: 2324 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2383
Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
V E Q +QE + L+ + +L K + + + ++ + +L
Sbjct: 2384 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2443
Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
K K++E+ + K+ + C ++KS +S K+ +P + D+ +S
Sbjct: 2444 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2503
Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
+++ +KL+E W EI K A+ S LN + +
Sbjct: 2504 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2560
Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
NTE+ ++ + ++ + +L +L+++ E KL +A++ + ++
Sbjct: 2561 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2620
Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
+ +NKT T + +A+ T +++NK + E+ +
Sbjct: 2621 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2657
Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
K + + LK D +T L + + K L + KW+ L+ D +KL
Sbjct: 2658 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2713
Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
ES + Q ++ + Q +VE + +++ + L Q+Q +Q+ L+
Sbjct: 2714 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2767
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
R Q T G +L E + +++ + + ++W++L
Sbjct: 2768 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2812
Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
+ + I + +++ +++L + +L +L+ S+ + PD + Q+ +
Sbjct: 2813 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2872
Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
I ++ + ++L E++ V Y ++L+ LE + ++ + K+
Sbjct: 2873 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2930
Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
Q L+ F + R FQ + + E + K H ++ LE+
Sbjct: 2931 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2978
Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
K+ ++ ++ +H+ E T N+ + E+ L+ QL +K + + ++
Sbjct: 2979 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 3038
Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
N+++ ++ ++ E+ L D Q N E+ + +G ++
Sbjct: 3039 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 3098
Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
+ + + L +L V ++ K ++D + Q+ K+ LE ++
Sbjct: 3099 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 3158
Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
F+E + K Q +K +D+ ++ + ++++ + Q L +++ AK L
Sbjct: 3159 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3217
Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
+++ + +++K D +LQ++ A+E+ L + + L K + Q+ +
Sbjct: 3218 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3272
Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
+ +L + + + +Q +K+ +AF +++ A M S K
Sbjct: 3273 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3332
Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
+ D+ R+ E L Q N +D L + Y L + + +A
Sbjct: 3333 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3392
Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
E S P ++ + L M + ++EE+E QD+ G+I S
Sbjct: 3393 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3448
Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
Q +L N+ K K A + E + ++ + + LS M E V
Sbjct: 3449 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3508
Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
Q S ++ ++++ K L L K + +++ + D + +LK
Sbjct: 3509 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3566
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
+S L +W +LL A+ E + + E +E L +++ L E T+
Sbjct: 3567 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3626
Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
+ E++++ L D + + +++ + + + + + + E V++ F ++
Sbjct: 3627 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3681
Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
+ ++ +K EL+Q + F ++ + L N+ + ++ QD+ +
Sbjct: 3682 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3736
Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
+Q EL+ + + L +N+ + L + E I+ ++E + +DI
Sbjct: 3737 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3795
Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
K+S +V K+ + + R++ EE+ L VE L K + +AQ K
Sbjct: 3796 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3855
Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
++ E + L+ L+ ++E P +A+E ++ ++ ++Y+ VS + ++
Sbjct: 3856 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3915
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
+ A ++ +++ + +WI T L + D L ++ Q+ ++ + L
Sbjct: 3916 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3971
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
H + D+L +S ++ + + Q + + L ++ + D + I SE
Sbjct: 3972 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 4020
Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
+ + +S++ L E EEH + E+I
Sbjct: 4021 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 4080
Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
E +I M KT +++ P G + + L IK E+V +++ L
Sbjct: 4081 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 4132
Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
I Q+ ++ ++I+ + + SLE + ++ + P + E+E++++QI
Sbjct: 4133 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4178
Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
+++ VD++ + L++ LKQ E
Sbjct: 4179 ENKNVSVDME-KLQPLYETLKQRGE 4202
Score = 90.9 bits (224), Expect = 4e-17
Identities = 379/2122 (17%), Positives = 783/2122 (36%), Gaps = 342/2122 (16%)
Query: 4938 RLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQ-----DLDTIRSNINNFF 4992
R L LL N +++ ++ Q LN+ E + + + DL ++ S++ N
Sbjct: 763 RKPLLKSSLLDQNLTEEEIN--MKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHK 820
Query: 4993 EFSKEVDE-KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
+ ++E +SSLK A IS LK T L + E ++ L+ + + L
Sbjct: 821 NVHRAIEEFESSLKEAKISEIQMTAPLK----LTYAEKLHRLESQYAKLLNTSRNQERHL 876
Query: 5052 HQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYK 5111
L SR A E+I W+N E + D ++ ++ K H E E+D K
Sbjct: 877 DTLH--NFVSR-ATNELI-WLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQK 929
Query: 5112 QWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQ---L 5168
+ + V + QL + R + M QW + + QH+++
Sbjct: 930 EENIKSVQEIAEQL----LLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 985
Query: 5169 LESITESENKIQILNNWLEAQE-----ERLKTLQKPESVISV----QKLLLDCQDIENQL 5219
E +++ L N +A + +R ++ K E ++ ++ LL + L
Sbjct: 986 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 1045
Query: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEW 5279
K+K + +LK + PL + +++ + + ++ + S +W
Sbjct: 1046 MGKAKTIIQLKP-----RNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKW 1100
Query: 5280 KIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAE---SSEGSWEK 5336
K+ +E + ++ F + + V L+ + Q +N+ +L E+ S SW
Sbjct: 1101 KVISPTGNEAMVPSVCFTVPPPNKEAVDLA-NRIEQQYQNVLTLWHESHINMKSVVSWHY 1159
Query: 5337 LQEVIGKL--------KGLCPSVAEIIEEKCQNTHKRWTQVNQAI----ADQLQKAQSLL 5384
L I ++ K + P + + Q+ + + + +Q + + + +
Sbjct: 1160 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1219
Query: 5385 QLWKAYSNAHGEAAARLKQQEAKFQ----QLANISMSGNN-----LAEILPPALQD---- 5431
+ K Y ++A R +Q+E+ + ++ NI + N + +I P +D
Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1279
Query: 5432 --------------IKELQHDV----QKTKEAFLQNSS-------------VLDRLPQP- 5459
++ L+ D+ K +E F Q ++ VL + Q
Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339
Query: 5460 AESSTHM----LLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMH 5515
+ SST++ + L + Q A L K+ K E E V++ + + +LK
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1399
Query: 5516 EEENLDRLHQQEKE-NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQ 5574
+E H E E ++ + T + D++ D + + +
Sbjct: 1400 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF-----------DWHKEKADQLVER 1448
Query: 5575 WIRATATALERCSELQGIGLNEKFL----YCCEKWIQLLEKIEEALKVDVANSLPELLEQ 5630
W R +L+GIG + K+ + + WIQ +E + ++ + + L Q
Sbjct: 1449 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1508
Query: 5631 QKTYKMLEAEVSINQTIADS---YVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQG 5687
KML +E+ + Q+ D Y Q + E++ + + D Q +
Sbjct: 1509 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT-----YRAMVDSQQKSPVK 1563
Query: 5688 VRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL--SAVKGQERFSLYQTRSLIHELK 5745
R+ + D +++++ D T L +T S + +E + H K
Sbjct: 1564 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1623
Query: 5746 NKEIHFQRRRTTCALTLEAGEKL---------LLTTDLKTK-ESVGRRISQLQ------- 5788
KE+ Q+ + + TL+ EK + + ++ TK E + + +Q
Sbjct: 1624 AKEL--QKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1681
Query: 5789 -----DSWKDMEPQL-----------AEMIKQFQSTVETWD-QCEKKI-----KELKSRL 5826
+ ++E Q+ +E +KQ Q + + D + E+KI +E K +L
Sbjct: 1682 DKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL 1741
Query: 5827 QV---LKAQSEDPL-------------PELHEDLHNEKELIKELEQSLASWTQNLKELQT 5870
Q L Q+E+ L EL + ++EL K+++ S + + +K +
Sbjct: 1742 QGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN 1801
Query: 5871 MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNK--- 5927
+ + ED ++++++ + E L L+ K+E+ D++ T + E K
Sbjct: 1802 FLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL-DKVVTTAIKEETEKVAA 1860
Query: 5928 ------------ELCAWLVQMENKVLQTADISIEEMIEK--------------------- 5954
L WL ++ K + A +++IE+
Sbjct: 1861 VKQLEESKTKIENLLDWLSNVD-KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN 1919
Query: 5955 ---LQKDCMEEINLFSENKLQ---------------------LKQMGDQLIKASNKSRAA 5990
L+ D ++ EN Q Q L++ + +
Sbjct: 1920 GNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1979
Query: 5991 EIDDKLNK-INDRWQHLFDVIGSRVKKLKETFAFIQQLDK---NMSNLRTWLARIESELS 6046
E +KL K + + H + KK+K T + ++L+K + + WL + E EL
Sbjct: 1980 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 2039
Query: 6047 KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANET--ECD 6104
+ D + +L Q+ D+ H + + + +L + +C+ + D
Sbjct: 2040 N-LEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 2098
Query: 6105 SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED-------WLKSAER 6157
+ T R + R+ + K + +D Y +ED L++ E
Sbjct: 2099 T-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA 2157
Query: 6158 TAACPNSSEVLYT--SAKEELKRFEAFQRQIHERLTQLELINKQYRRL--ARENRTDTAS 6213
TA+ S + + + +L+ +A Q QI + +E + K L AR + +
Sbjct: 2158 TASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2217
Query: 6214 RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWL--TEMDLQLTNV 6271
+++ + + R+++L + V +L+ + + + +L W+ E L+
Sbjct: 2218 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277
Query: 6272 EHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEEL-- 6329
+ + D + + +Q+I + I+ + ++ ++ ++P A ++ ++++L
Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337
Query: 6330 ------HRY------CQEVFGRVSRFHRRLTSCTPGLEDEKEA-SENETDMEDPREIQTD 6376
H++ +E+ +V F LE + +A +E + +D E+
Sbjct: 2338 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2397
Query: 6377 SWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEE 6436
E E + H + G + + L + T ++ ED
Sbjct: 2398 MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-----LVLEKTNNLSKKFKEMEDTI 2452
Query: 6437 GPYYSALSDVE--------IPENPEAYLKMTTKTLKASS--------GKSISDGHSWHVP 6480
A++ + + ++ ++++K TTK + GKS+ D
Sbjct: 2453 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2512
Query: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNG----- 6535
S PE G ++ + A +TP K K G VLNG
Sbjct: 2513 WSLKTPEIQKVNNSGI-SLCNLISAVTTPAK----------AIAAVKSGGAVLNGEGTAT 2561
Query: 6536 NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIKQNLQQLNSDISAIT 6587
N ++ + GL I + + +E + + EL+ KL LQ+ + SA+
Sbjct: 2562 NTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS---KLQKAQEESSAMM 2618
Query: 6588 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQ-- 6645
WL+K + P+D + ++ +V++ + V + E L+
Sbjct: 2619 QWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN 2678
Query: 6646 TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
++PE+ + L ++ W+ + L +S F + L WL
Sbjct: 2679 PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLV---E 2735
Query: 6706 RRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIE 6764
+ V P DP L R+++ L +E R+PQ + L +L + + +
Sbjct: 2736 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2795
Query: 6765 --AEEKVHVIEKKLKQLREQVS 6784
+E++ + +K L Q+S
Sbjct: 2796 GIVKEQLAAVTQKWDSLTGQLS 2817
Score = 88.6 bits (218), Expect = 2e-16
Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)
Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
++LS G+ +QE++ + L L+ I ++ + I + + +I
Sbjct: 4097 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4156
Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
+ P++ A + K + ++K+ YE K+ +EM A S KD
Sbjct: 4157 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4216
Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
K V + V +WEN LV E + V+EL +++ + S++ T+ ++ + L
Sbjct: 4217 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4276
Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
+ + +K++ E ++EE + E +D + + L + ++P +K
Sbjct: 4277 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4333
Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
+ + W +N+ +D + L A+ + + + +W + A K+ D E
Sbjct: 4334 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4393
Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
+K++++ +Q SE ++ E++ L +E+ L+ ES L +++ + L
Sbjct: 4394 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4453
Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
+ H L G + + + LD+ + TE LL P ++E +
Sbjct: 4454 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4513
Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
+LQ K L+E+ G L +L L +++++V + +K L
Sbjct: 4514 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4573
Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
+K + + ++ W ++ + +L K ET K EQ + E +
Sbjct: 4574 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4631
Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
K + + + PK+ + + + + E +E+ R +LE++L +
Sbjct: 4632 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4691
Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
+ ++ WLT E+ P ++ ++F + REQ + +
Sbjct: 4692 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4751
Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
LK F++++++++ L+ R++ ++++L E + F++ ++
Sbjct: 4752 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4809
Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
W++E ++SL + ++ + KIK + E + ++ + L
Sbjct: 4810 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863
Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
+KT L+++ ++WD + + E+ LL ++ + + L L
Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4923
Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
++ + + + + +K F K+ TS ++ LK L+E ++ + S+
Sbjct: 4924 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4983
Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
+ E+ E++ L+ +R+ + + V L L +
Sbjct: 4984 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 5043
Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
P D+ A+ + + +E +L + L K +LA+ T II+
Sbjct: 5044 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 5103
Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
+ + K + RLAS AKQE +E L + ++ + K K +P ++ +
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5163
Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
+ +E T++ V+K+ + ++
Sbjct: 5164 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5190
Score = 58.2 bits (139), Expect = 3e-07
Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)
Query: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4885 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4942
Query: 6613 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6672
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4943 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 5002
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6731
S + L +L Q ++FH + LL WLA A+ R + D + R L++ +E M
Sbjct: 5003 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 5061
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6779
K+L E++ +++ + +++L H + + + +I + +++
Sbjct: 5062 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 5107
Score = 53.5 bits (127), Expect = 7e-06
Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)
Query: 6571 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6627
K+++ +Q Q + A+ W+ +L M+ +D++ ++ +++ L++
Sbjct: 4353 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4410
Query: 6628 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6685
+ + +N ++ L+ TE + +Q L +L L+W++ + + + + L +L+
Sbjct: 4411 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4470
Query: 6686 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6743
F LL WL + QK DPKA L + L+ +++ Q V
Sbjct: 4471 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4526
Query: 6744 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6797
+ + + N L+ GE+ + K+ V+ ++ + + E+ Q L G A
Sbjct: 4527 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4580
Score = 45.4 bits (106), Expect = 0.002
Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)
Query: 585 LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
L W T+ E L + + K EI+ L L H + +N+AGN L+E S
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4540
Query: 640 NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
S++ +L LN+RW+ ++ KT+ +KQ L +
Sbjct: 4541 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4582
Query: 700 FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
F ++ E+ Q + E+H ++ G + AK E+L +E+ A EAK
Sbjct: 4583 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4631
Query: 759 QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
EE+ K L+ KG M +E + DI N+ +E ++ V + K+
Sbjct: 4632 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4676
Query: 818 EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
E K K++ L++ ++ S ++ +++ +A+Q L P +
Sbjct: 4677 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719
Query: 878 -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
I +HK + S+ + + + K LK + + ++ V ++WE
Sbjct: 4720 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4779
Query: 929 LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
+ VQ+L +E+G+ D+ K KQ ++ KL+ K L E E
Sbjct: 4780 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4829
Query: 986 EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
+ QL H E + L + + R LK+
Sbjct: 4830 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4865
Score = 43.9 bits (102), Expect = 0.006
Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)
Query: 6564 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6623
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2931 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2985
Query: 6624 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6681
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2986 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 3044
Query: 6682 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6741
SL + + + + L W+ +N ++ DP +L L+KE+ +
Sbjct: 3045 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 3101
Query: 6742 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6801
V++L +NSLL + + +E +I+ K+ + EQ+ L +N
Sbjct: 3102 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 3157
Query: 6802 SFDEV 6806
F EV
Sbjct: 3158 EFQEV 3162
Score = 41.6 bits (96), Expect = 0.028
Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
W+ ++ + ++ + K++ L Q + + WL TE +L KP D + IE
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4506
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
+ + + + +++ V +VN + + +++ + E++ LQ++L L+ W+
Sbjct: 4507 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4566
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ + L +L Q + FH ++L WL + H+ K L E +E + +
Sbjct: 4567 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4620
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6778
E+ + +E SL+ KG +D +EK +E KL +
Sbjct: 4621 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4677
Query: 6779 LREQVSQDL 6787
+ ++ + L
Sbjct: 4678 RKTKLEEAL 4686
Score = 40.0 bits (92), Expect = 0.080
Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 8/153 (5%)
Query: 6557 RWEMIQAQELHNKLKIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 6613
RW+ + + K ++ L+Q + +I + WL TE L K + + +
Sbjct: 4558 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4617
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGA 6671
L V E+ AF+ + S+ ++ L P+S E + + L WE+ +
Sbjct: 4618 LNVH--MEVCAAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETK 4674
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6704
++ + L ++L +FH Q+ + WL A+
Sbjct: 4675 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4707
Score = 38.9 bits (89), Expect = 0.18
Identities = 45/216 (20%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 6577 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6634
QQ + A +W+ +TE +L L + D +L+V++ EIL+ D LV
Sbjct: 3923 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3982
Query: 6635 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6694
S K E ++ +L ++ ++ L ++ F + +
Sbjct: 3983 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 4039
Query: 6695 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6754
L WL ++ + + P + L + + E QL + + E +P +D + + LL
Sbjct: 4040 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 4097
Query: 6755 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL 6790
GE +EK + Q++E V + +AL
Sbjct: 4098 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVAL 4132
Score = 37.0 bits (84), Expect = 0.68
Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)
Query: 6558 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6610
W + ++ H++ ++ Q N + D + WL + +L L + ++ Q
Sbjct: 3682 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3741
Query: 6611 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6670
+ ELRV + +L+ + +AL+ + + QT E +Q +L + ++
Sbjct: 3742 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3797
Query: 6671 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6730
L Q+L + H + L WL + K + + + R +
Sbjct: 3798 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3855
Query: 6731 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6783
+L+KE + +D L E+S++LL +G + E E+ ++ + Q E++
Sbjct: 3856 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3915
Query: 6784 SQDLMALQ 6791
++ Q
Sbjct: 3916 DAAILRSQ 3923
Score = 36.2 bits (82), Expect = 1.2
Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)
Query: 310 KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
K+++++L K +++ Y ++ ME N + + L ++ + D + ++L+
Sbjct: 4396 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4449
Query: 370 WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
WD L+ +I + KL AL L + AWL E L+ E D +A+ +
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4508
Query: 423 ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
+Q + +S ++ N L+ +E ++L NKLE + +R N+LE
Sbjct: 4509 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4564
Query: 476 K 476
K
Sbjct: 4565 K 4565
Score = 33.5 bits (75), Expect = 7.5
Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)
Query: 6647 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6706
+S + L+ L ++ W+ V L+++L+ C F ++LL W+ +
Sbjct: 3447 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3504
Query: 6707 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6766
A+ P A+ + + +E L++ L +R+ V++++ + D ++
Sbjct: 3505 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3564
Query: 6767 EKVHVIEKKLKQLREQVSQDLMALQG 6792
+++ +++ + + L + L+G
Sbjct: 3565 KQLSLLDSRWEALLNKAETRNRQLEG 3590
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 234 bits (596), Expect = 3e-60
Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)
Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
+N I + + S K LPG +Q S++Q E +QES + +LE++
Sbjct: 983 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1042
Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
+ K E+ S + N + ++N ED R + +++ PLE D +
Sbjct: 1043 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1100
Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
+ ++ E EKL +LE K + + E ++ + +VL N+
Sbjct: 1101 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1160
Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
S+ ++D L + LK N ++ +++ ++ L E A++ DK +++
Sbjct: 1161 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1209
Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
+ +K++ + +++++ L+ + + +M K E + QL
Sbjct: 1210 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1268
Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
W+ V QI + + + + +DT L Q ++ + +E S
Sbjct: 1269 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1324
Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
L T L K S E++MK+ ++ +K E +K +
Sbjct: 1325 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1377
Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
+Q K R +M+ + +L L + + K D + ++ +S
Sbjct: 1378 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1434
Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
L EE K+ V + S+++ TL+D + K S+++ K E+ S
Sbjct: 1435 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1494
Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
I+ F +QES L+ + +++ + T ++K +
Sbjct: 1495 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1554
Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
Q+E +E GI L + N + E + D +LK + + +Q+ +Q +
Sbjct: 1555 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1612
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
+ +K F L+E + + Q ++ L+ Q++N+ +K E NLK D
Sbjct: 1613 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1666
Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
++ TAIK + Q+ + K + + L+W S +D+ + K K++ I+Q
Sbjct: 1667 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1721
Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
T F+E GK AI + + ++ D + + N L+Q+ +K K
Sbjct: 1722 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1770
Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
++II ++++ + + ++L K L+ EE +KL K ++ + + E + E ++
Sbjct: 1771 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1827
Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
K + Q++LE + + LQQ L NLE I + + ++F E V
Sbjct: 1828 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1887
Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
+ ++ +T + + + S+ +V+ KL D L + +
Sbjct: 1888 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1947
Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
+ N L D + Y++A + + + EA + P VD N + LE Q
Sbjct: 1948 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2007
Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
++ S ++ L + ++ S AK +Q TL ++V + + ++ + + +
Sbjct: 2008 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2067
Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
L + +++ + +E+ L + +PL+ + + ++ L ++ +
Sbjct: 2068 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2126
Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
+ + + ++ + L + L ++ KE EELK + +
Sbjct: 2127 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2183
Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
+ +NL E+L +TK A TE ELS+ + + ++ E+ + +
Sbjct: 2184 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2235
Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
+L +LL + S +P V ++ ++ ++ ++ +++ KE V + ++
Sbjct: 2236 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2288
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
+F + +LK++ ++TT + E + E+ + + +K L I +
Sbjct: 2289 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2348
Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
I + + V PA+ + V+ L + +E +N+ L S S Y
Sbjct: 2349 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2408
Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
++ KI E+N L ++K ++ S ++ Q++ K W
Sbjct: 2409 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2468
Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
EL +K+ EL ++ +++E++P +A W L ++Q+++Q
Sbjct: 2469 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528
Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
R +L +++ + ++ + + W+ +++ P D L+ VQ+ L+
Sbjct: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2587
Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
+ + + + LS E L ++E VT + L D
Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2647
Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
+ ++ +S+ + +S + L +K + H LE + MK+ I
Sbjct: 2648 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2700
Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
Q K + V Q + L + E + E + L+ ++K + +++ EN Q
Sbjct: 2701 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2754
Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
L + A + MS D L + E + L+ E L+ D K + L
Sbjct: 2755 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2813
Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
H+ ++ + L E + + K N + E +++ES K+
Sbjct: 2814 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2873
Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
E+ E W + K ++EE + + +NS+A++ SL
Sbjct: 2874 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2916
Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E + N T E D +D L +V+ TE LH+ K +
Sbjct: 2917 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 2972
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
+ Q+ E Q E+ + L+ K+Q + D+
Sbjct: 2973 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3004
Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
+Q + L+T + +L+ K Q+ L ++ ++D ++ ++S+ + + L
Sbjct: 3005 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3056
Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
++E+I E S+Q D ++ LE K F I ++M+ Q+ + D++
Sbjct: 3057 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3110
Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
++P G++ + Q + + +K +E +++N
Sbjct: 3111 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3147
Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
+ M T+ +L LE L ++ + L + EE K+L E + L +
Sbjct: 3148 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3206
Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
+L+ + E + ET+ +L + ++ L + + W G+
Sbjct: 3207 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3263
Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
+T L D++ + R+ L+ L + +Q+ ++ L ++
Sbjct: 3264 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3323
Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
++ + Q + V Q+Q+ L++ +S V ++ EGE++ +V
Sbjct: 3324 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
L+ + LDS W L R +L V Q L+ + E + +++L +
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
+Q AL+ I NH + V+ ++ S++ ++Q++ F
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3501
Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
QV ++I +EKS LQ L + F E+ L L + L +S+ + + E L
Sbjct: 3502 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3560
Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
++ S + ++ +I + + Q L G +L+ + E ++ ++ ++ ++ + K
Sbjct: 3561 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3620
Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
L+ L+ + ++L WL+ + L ++ Q L + +R
Sbjct: 3621 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3677
Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
E KE +L ++ + + LL L L +A+ +++ ++ + E
Sbjct: 3678 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3735
Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
++ + +A +SW+ E + + + + LQ K F ME +
Sbjct: 3736 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3793
Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
+K I D V ++ C E K+ + + + L E Q R ++
Sbjct: 3794 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3853
Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
N+ + E+L +TE+++ I + L A +TL Q+ E +++L+ + + +
Sbjct: 3854 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3909
Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
++ L EL ++ Y+ ++ + ED R +DE + + +++
Sbjct: 3910 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3969
Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
Q+ S++ +++ + + EV + + + +K V + +E L+ E L+ +E
Sbjct: 3970 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4025
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
+ G +K A+ +++K W ++ + ++ K +++L
Sbjct: 4026 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4073
Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
+ + H +K + + L + + + + + A + I+E +Q+ +
Sbjct: 4074 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4132
Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
+ S L +P + L SL +A LE+ +
Sbjct: 4133 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4192
Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
F++V L+ G LE++K I ++ +QQ+ E LNH L
Sbjct: 4193 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4248
Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
++ + E S K + D L + W + R +L+G L +F + +
Sbjct: 4249 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301
Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
+ + L E L P+ +E + + +L+ +V +Q+ ++ L+++
Sbjct: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4361
Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
+ E + L RWQN ++ QRK +DG +RQ + F +E+L ++LTDT
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
L A K L E N + F+ + T ++ G+++L +
Sbjct: 4422 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4476
Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
++ + I+ L++ W+ +E +L E + + + E + + I L Q L S
Sbjct: 4477 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4536
Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
L + + + + + K + S + + EL L +DV+++K +
Sbjct: 4537 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4594
Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
+ +WE + R+ R + ++D F+E +L WL + E + +I+ +
Sbjct: 4595 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4654
Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
K Q K+ + + + G L K S ++DD L+++ D+W +
Sbjct: 4655 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4714
Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
R KL+E F Q + L WL R+E +L+ +PV D+ + +
Sbjct: 4715 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4771
Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
+ Q+++ + ++ V+++ L+ S + ++ + L RW +CA+S+
Sbjct: 4772 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4826
Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
++ ++E R ++F +WL AE+T P+ + L T + + + F
Sbjct: 4827 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4882
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+++ E+ +L + D+ + +K + R++ + +RL
Sbjct: 4883 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4942
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
+ E++L WL + LT+ + ++++ L F +E+T
Sbjct: 4943 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5002
Query: 6299 KIDQL 6303
+D++
Sbjct: 5003 DVDKV 5007
Score = 198 bits (504), Expect = 1e-49
Identities = 116/287 (40%), Positives = 157/287 (54%), Gaps = 35/287 (12%)
Query: 7 LPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHV 66
L E+++ +D+ + E++ QKK FT WIN L + ++DL+ D++ GH
Sbjct: 11 LYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHN 68
Query: 67 LLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILG 126
L+ LLEVLSG LPR+KG F N++ AL +L+ R +KL+NI DI DGNP + LG
Sbjct: 69 LISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLG 128
Query: 127 LIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKA 186
LIWTIILHF I D+ V S MSA++
Sbjct: 129 LIWTIILHFQIS----------------DIHVTGESE----------------DMSAKER 156
Query: 187 LLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAF 246
LLLW Q+ Y + +F + WR+G F AIIH RPDLIDM +V +SN NL AF
Sbjct: 157 LLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAF 216
Query: 247 RIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGE 293
+AE ++ + RLL+PEDVDV PDEKS++TYV+ P GE
Sbjct: 217 YVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGE 262
Score = 193 bits (490), Expect = 6e-48
Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)
Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
N EE N FV L+ D +Q ++ + + ++ ++ +A+E+F +SL+
Sbjct: 597 NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 656
Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
AK+ S+ Q+ LT K +H ++ + K+L+ S ++ ER
Sbjct: 657 EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 696
Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
DT + A + I L+E V +++E N + + EL++ NI+
Sbjct: 697 HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 756
Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
VQ ++ L++ + +R + +L + ++H++E F D +E
Sbjct: 757 SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 816
Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
T C + + + LV E +E+ +L+ N T+I
Sbjct: 817 ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 875
Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
Q S L+ S K R EI I K++ N H K +
Sbjct: 876 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 932
Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
+ F PP KEA +D+ + E Y+N+ L LW + N+K+V+ W
Sbjct: 933 MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 980
Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
+ + E DR R + E + ++ +Q + E E QV S
Sbjct: 981 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1032
Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
+ ++E V C + ++L ++ + ES+ L S+ I
Sbjct: 1033 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1077
Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
+LE + ++++Q + + L + +T E +LKK+ E + D T + ++ FS+
Sbjct: 1078 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1136
Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
+ + + N+ + + S T K+K V+ V
Sbjct: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1177
Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
LK+ + + L K + +L ++ + +E + S + E+++ Q L+D+
Sbjct: 1178 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1235
Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
L+K +E +K +E + + + E++++V Q++N L++ G + +
Sbjct: 1236 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1294
Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
+ +D + +T R++ E + E K L T+ L ++ E+K+S M
Sbjct: 1295 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1348
Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
E + E+ +K+ L A +++ + ++ S A L+ + D+
Sbjct: 1349 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1405
Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
++ + L + Y L +EK L E +K +++ ++L+ + LK ++
Sbjct: 1406 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1465
Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
AG + ++ K+ L +A L L G+ + + +N + L+
Sbjct: 1466 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1523
Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
+ L L+QLQ+S + D V +E+ + DL T +N +E
Sbjct: 1524 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1583
Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
D V+ + K ++LQ+ G+ + + + K+ + G+K+ ++D
Sbjct: 1584 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1636
Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
K+L +E +L AK + C LK+++S ++ +K T+ ++E T++
Sbjct: 1637 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1679
Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
AAV++LEE DW N D E A +K + Q +S EDE
Sbjct: 1680 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1739
Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
N L+ ++D + Q E + + Y +++A+ I Q + T++ ++L
Sbjct: 1740 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1794
Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
G S + + L + + LK + E+ LA E MK + +E L+
Sbjct: 1795 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1844
Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
D + L + ++ + ++E D + L K E++ +H +T ++
Sbjct: 1845 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1904
Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
LE+ + +V+ +++Q+K + + N + + L + QH
Sbjct: 1905 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 1964
Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
L L++ E A + D LQ L+GQ Q + K+
Sbjct: 1965 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2024
Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
K +++ ++++ ++E L E ++ + +++ + E +
Sbjct: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
W N+ L +PL + I K + I RQ S+ ++ E+VK + +
Sbjct: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
S L ++DL ++ K + ++E +L+ + F + + E++T +
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2203
Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
V+ + +E H LE L+EI S G+ + + + E+
Sbjct: 2204 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2260
Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
N + F +ED +K K Q + V+ + ++ +K +Q
Sbjct: 2261 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2320
Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
E+ +Q L E+ N G+ + NL +T I V V +
Sbjct: 2321 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2378
Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
G N + + + T + ++ L++KI +L+T + K Q +
Sbjct: 2379 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2435
Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
A+ ++KM + K A + E + L Q + K + L D++ +
Sbjct: 2436 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2495
Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
L EN ++ + K++L E D ++ L + ++ K + N + +T
Sbjct: 2496 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2549
Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
L Q ++ +L +L ++++ + ++ + ++ + +TA I +
Sbjct: 2550 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2609
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
E+ S V+ +L L + R + ++ A T+Y+ + + ++ L
Sbjct: 2610 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2669
Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
+ ++ + D N + LE + ++E++ I Q L E L A +
Sbjct: 2670 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2721
Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
+ +Y EL + + ++FK E +AE ++++ + +++M D + ++T
Sbjct: 2722 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2778
Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
+ S P+S + + LE L + SK L + ++ + + + LL+ + +E
Sbjct: 2779 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2836
Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
+ L L + W+ K+ +E W C+ +E K
Sbjct: 2837 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2896
Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
F + E E I L +LQ+E+ + + + + T+E L+
Sbjct: 2897 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2956
Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
+ E + ++ L + Q+ + Q V + S A E + + S +
Sbjct: 2957 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3016
Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
+LQ QK+ + ++ ++ ++++ + + T+ + Q+H S+Q +E
Sbjct: 3017 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076
Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
S L+ +G F+N + ++ +++E + A + E +K E I + E
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3136
Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
L +S A M EE + L ++E + +Q +K +++AQ ++++
Sbjct: 3137 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196
Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
L+ ++SKL E +Q E + Q M+ I P Q QQ
Sbjct: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
++++ R +QL +A + + D L+
Sbjct: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
S +W+ +T L+AN A++ ++ +Q L+D + + + I + E +
Sbjct: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3373
Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
+ E + + +++LS ++ AL K Q++ ++ ++ + + ++
Sbjct: 3374 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3433
Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
I+ L++ E EE + + + ++I K + + VS L++ +
Sbjct: 3434 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3493
Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
V + + ++ + ++ELL+ + + E+ L LN + S +
Sbjct: 3494 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3553
Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
+ L + Q E+ +++ IL Q + L++ LK T + ++ + E + +
Sbjct: 3554 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3612
Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
R +T VA+ +L RR ++L VE E+ + G+E +A
Sbjct: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
+ P+ K++K + + SS + +E K+ DN ++++ +
Sbjct: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E+ LR Q ++ ++DA+ EK +
Sbjct: 3733 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3769
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
++ L Q + ++ +Q+ +++ + ++ ++ ++ C ++
Sbjct: 3770 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3816
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
E +++ KL V N + + + E++ + + L ++E L P L+E
Sbjct: 3817 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3870
Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
+SI+++ P + RQ+ + +Q+ EL E K I K PQ + +
Sbjct: 3871 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3925
Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
+ QE +A S + DV D +S Q DK + L + +L P
Sbjct: 3926 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3985
Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
+ ++ Q+S N + + Y T ++ K +
Sbjct: 3986 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4045
Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
L+ + N+ T E ++ L +K + L +T+ + + LE P +
Sbjct: 4046 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4104
Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
QQ ET+ E+ L L + +L+ A P + ++ + D L
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4162
Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
+ A R L+ + YQ+ ++ ++ + + S + + L + Q
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4222
Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
+ K++AY ++E AE + K+ +E ++ + + + +L+ + DS+
Sbjct: 4223 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4278
Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
+ R +L + Q Q AL + + L + ++K G K + ++A ++
Sbjct: 4279 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4338
Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
N + Q V A LI++ SA S LQN+ ++ V EK+ Q +
Sbjct: 4339 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4394
Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
L L++ + F L++ L L+++ P L E +E+L + + ++
Sbjct: 4395 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4450
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
K + +G+Q++A CP+ ++ I L+E+W S+ K++ +L+ L
Sbjct: 4451 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4508
Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
+ ++ WL ++ TLN SL LDT+ I+ F+ EV +S
Sbjct: 4509 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4561
Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
+ +I + HLK + D ++ L + +W ++ +L + L +
Sbjct: 4562 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4621
Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
+A ++++ W+ E + S + + + ++K L +HKEF+ + K + D N
Sbjct: 4622 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4679
Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
++ L + S + + + L E+ +W + G + LE+ L + + +
Sbjct: 4680 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4737
Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
Q L +WL E +L Q I V L+ + + + +L ++ ++ LK+S L
Sbjct: 4738 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4797
Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
G+ D +S + Q+ S+ V L S Q+ L+ + + V + +
Sbjct: 4798 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4851
Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
+ ++ + L + L++L D+ + E+ + + K + +V I
Sbjct: 4852 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4910
Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
T K W + +A +++ Q A + A A L + + Q A +++
Sbjct: 4911 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 4970
Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
+ E++P ++++K L + Q E + +D++
Sbjct: 4971 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007
Score = 179 bits (455), Expect = 7e-44
Identities = 674/3683 (18%), Positives = 1386/3683 (37%), Gaps = 526/3683 (14%)
Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
E +LEN+K + E+ ++L + + Q + L L+Y E L RLE A L++T
Sbjct: 635 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 691
Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
+ L R T +W E A +W + ++ K
Sbjct: 692 RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 740
Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
E+ RE LD +E + + + E E L + Y ++ Q + L Q
Sbjct: 741 HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 796
Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
+ Q++ E++ E +E T +Q+ + K ++LVQ ++E+
Sbjct: 797 VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 854
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
+ + N + T Q P S+ K + + I + +I+
Sbjct: 855 EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 902
Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
TI + +A + NE + S + + N ++
Sbjct: 903 I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 954
Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
++Q+ +N+ + WH +NE+D S V I PG+ Q+ + NL
Sbjct: 955 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1014
Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
F+ + + SQ ++ + +QL K V + Y +LLKS E + S ++ +
Sbjct: 1015 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1074
Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
+R L + + + ++ +L S+F E + E + L + ++N+
Sbjct: 1075 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1134
Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
Q S+P ++ + V+ ++V SM + K+KT+ L + E E
Sbjct: 1135 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1194
Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
L E ++ + ++ I+ + ++ E+ + VF LQ K + +
Sbjct: 1195 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1244
Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
E+ K ++ ++D E Q++ + H+ D ++L L+G I + K
Sbjct: 1245 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1295
Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
+D + ++ T + +++ Q + + ++ V+E + + K++
Sbjct: 1296 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1351
Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
++ + Y A V++ E++ + ++ ++ P ++ R SS+ I+
Sbjct: 1352 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1397
Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
QE + + T ++ ++T DSL + E SL +
Sbjct: 1398 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1456
Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
E+ PP + S + E E T E E+
Sbjct: 1457 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1516
Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
KT L ++ +V VE E + A+ QQ +++L G +LT+ E
Sbjct: 1517 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1575
Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
H+ AF++ E K Q + Q + + + L V N E EK S
Sbjct: 1576 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1633
Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
++ I +K +E + + + +NL EL+ +VT + +K +Q+ E K
Sbjct: 1634 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1691
Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
+ D++ ++ ++++ ++ Q N T + A E++V N
Sbjct: 1692 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1741
Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
G+ L+E V +G TTQ E+L
Sbjct: 1742 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1760
Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
Q+ ++ Q +++ + + + ++ L S EE ++ + +E +V
Sbjct: 1761 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1816
Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
HYET LA S+KK L ++ LE FD EH + +
Sbjct: 1817 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1861
Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
+L+AG D ++KR +I K L+ ISG V A+ K D V
Sbjct: 1862 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1919
Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
+ V + D +R Y+ + L+D++D Y + S +
Sbjct: 1920 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 1974
Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Q + + + E + + + L L++TK ALQ QI + +V +KL ++
Sbjct: 1975 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2030
Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
+LP+ ++T + V + L + + KLQ L + + + +
Sbjct: 2031 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2089
Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
+ S+L V L + IS ++++I G+ + + + K+ + + +
Sbjct: 2090 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2149
Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
L+ ++ L ++ + K L +++ L + + S++L +LE+ L
Sbjct: 2150 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2209
Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
+V++ ++ + + F E K ++ SL + S H +D A +
Sbjct: 2210 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2263
Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
+K+ + + + +E + Q + + + + SW+ +T+ + + PS A
Sbjct: 2264 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2319
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
+ L+ K+ + + K + VN S + L + + E
Sbjct: 2320 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2379
Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
EF + G +++ + + +L KI L L + +++ + +
Sbjct: 2380 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2439
Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
WL+ + Q+ P +V+ + + E +L + ELK L
Sbjct: 2440 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2499
Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
++ P + + ID +Q+ R L + + T Q+V L++W + +
Sbjct: 2500 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2559
Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
L V P+ + L Q + +Q L E + + +E+L Q +
Sbjct: 2560 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2606
Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
+ + G PS+ I++E+ ++W + ++D+ + Y + + +
Sbjct: 2607 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
L + K +S + + + L A + +E+Q + ++ K +A ++ S L + +
Sbjct: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2724
Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
++ L G L S Q+A +++ + A+ +F +DF L++ K
Sbjct: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2780
Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
EE+N LD L K++ D LTAQS E + LK S
Sbjct: 2781 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2834
Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
+ A LQ + W ER ++L+ EK L E+ WI +
Sbjct: 2835 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2892
Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
E +K + NS+ +L QK V + A+S LL EI+
Sbjct: 2893 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2943
Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
E +T+ +K L + + + +K ++ + +++++F + R L L
Sbjct: 2944 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3003
Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
++ Q + Y T + + + K + + + A L A + ++ +D K V ++
Sbjct: 3004 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3059
Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
+ + Q+ E ++ ++ + I+E+ S+ + S P+ E
Sbjct: 3060 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3119
Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
L +KE IK + L A N +T K L D++ +K +E L +Q L
Sbjct: 3120 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3179
Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
R R++++E + F K KE L + E + +E M +
Sbjct: 3180 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3239
Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
QK EEI + + +G LI+++ KS + + ++ L+ +N RW+ L +
Sbjct: 3240 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3296
Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
R +L+E + + +L +W+ E EL + + ++ ++ EQ+ LQR
Sbjct: 3297 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
++ + VE V+ + + A E D ++ + LD RW + + R
Sbjct: 3356 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3408
Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
++E + Q+F + +WL + E+ + +E++ + +A + I
Sbjct: 3409 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3468
Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
++ L Q I + + L+ RE++ S+L + +Q W +Q + + L+
Sbjct: 3469 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3523
Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
+ F ++ WL E+ +L+ +V+ +S + +L Q++I L +DQ
Sbjct: 3524 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3583
Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
++ G +L++++ + ++I+D+LE + +++ + + RRL S
Sbjct: 3584 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3643
Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
CT + E E ET + P+E++ ++ + + + S +
Sbjct: 3644 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3703
Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLK 6457
P R G E V+ D+ + D E D + L + + +A L
Sbjct: 3704 VPWRAREGLEKMVAEDN--ERYRLVSDTITQKVEEIDA-----AILRSQQFDQAADAELS 3756
Query: 6458 MTTKTLKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKL 6517
T+T K K +S G ++E D+ + + + K
Sbjct: 3757 WITETEK----KLMSLGDI---------------RLEQDQTSAQLQVQKTFTMEILRHKD 3797
Query: 6518 LLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQ 6577
++ D K G +++ ++E + ++ +D I ++ + + +
Sbjct: 3798 II---DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
Query: 6578 QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVN 6637
Q + WL +T++ + L P + + + + + +++ + +K + +N
Sbjct: 3855 QFWETYEELWPWLTETQSIISQL--PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3912
Query: 6638 VSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLL 6697
+ + L+ E +Q + L+ + V L +++ Q FH +L
Sbjct: 3913 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 3972
Query: 6698 LWLASAKNR-RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 6756
L R RQ ++ A+ + E E + ++ + QP + L++ ++ +
Sbjct: 3973 ESLERIVERLRQPPSIS---AEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4029
Query: 6757 GHGEDCIEAEEKVHVIEKKLKQL 6779
G D + ++ KL Q+
Sbjct: 4030 SGGTD---KDISAKAVQDKLDQM 4049
Score = 174 bits (440), Expect = 4e-42
Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)
Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
LQ Q E K F +KL A ++ + K +L ET + V + LE S+QC
Sbjct: 3121 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3177
Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
LL + + +E K LE S L S+ L+++ +++ + +G +
Sbjct: 3178 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3227
Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
+ Q LN +GKQ S S LE + + +W
Sbjct: 3228 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3287
Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
+LNKK+ +LQ L H + + L W+ ++ + K S + ++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3343
Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
+ I + +D++ S + G ++ E D + L+ + +W L+ +
Sbjct: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
+L + + + + + W+ +E + + + + + AS+++ + +HK
Sbjct: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3461
Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
++ ++ + + V+ QSL LS+ + + + +F++ W+ + +
Sbjct: 3462 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3514
Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
+ + L+Q L + E++++++N WL ++L L Q+ E + +
Sbjct: 3515 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3573
Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
+LL Q+++ L L+ LKQ+ V +++D I ++ + + T V +
Sbjct: 3574 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
L+ ++Q + +++L ++ + + + + V+ E + Q+ + L+ E
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3682
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
A++++ + L EV L L P A E +E+ ++R+ V+ I ++++ + +
Sbjct: 3683 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3742
Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
+ + A + + + E K L +I + QD Q VQKT
Sbjct: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3790
Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
L++ ++D L + S H ++ S + ++K L ++ + + +
Sbjct: 3791 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3844
Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
+LE + L+ E + L E S ++ + A + + E +L
Sbjct: 3845 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3903
Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
K + MN+ T L S +G + EK++ + Q+ E + +EA+
Sbjct: 3904 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3958
Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
K+D + SL ++E+ + + AEV I + I++ S + LQ L T
Sbjct: 3959 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4018
Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
++ R E + S TD+ +A + + +D +V W++ T VE
Sbjct: 4019 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4073
Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
+F D L+ +K + F S+ + + E +EI + +
Sbjct: 4074 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4133
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
L G +L+ K V + I +L +W + + I + + ++ Q + ++
Sbjct: 4134 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191
Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
+ + + + P + DL K+ I+EL+Q + Q E++ + +A+L
Sbjct: 4192 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4250
Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
+ E D +++ + L W+ L R+ R+ ++E L F EL AWL
Sbjct: 4251 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4310
Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
E + + + + IE + ++ L ++ ++ + + G+ LI++S A+ +
Sbjct: 4311 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4370
Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
+KL +N RWQ++ + R ++L + + +L+ WL E L SKP+
Sbjct: 4371 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4429
Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
+ + EQ ++ ++ A E+ ++ C E + I Q
Sbjct: 4430 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4482
Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
+L +W ++ ER+ K+EE L +F + F +WL AE+T + ++
Sbjct: 4483 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4542
Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
+ ++ + F +++ Q+ ++K L ++ +K ++ RW+ +
Sbjct: 4543 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4602
Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
+R+ R L + ++F ++ WL E + L + +E ++ D ++ Q
Sbjct: 4603 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4662
Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
FQ+ + + D G L +K+ D L ++D L EL + G+
Sbjct: 4663 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4715
Score = 160 bits (404), Expect = 5e-38
Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)
Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
LT S LS G T+ L + A T G+ + + P+ SL+ KL +I++
Sbjct: 530 LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 587
Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
+L K S++ L E +I L + E++ Q + SDL + + S L++H
Sbjct: 588 LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 641
Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
KN + + +LKE + SE + + KL LE + +K+
Sbjct: 642 ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 691
Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
++ ++HL H +S + L + E + A + + + R +D H L +
Sbjct: 692 RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 747
Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
L +EE K ++E E+ L +A A + Q+ + QL ++++ +
Sbjct: 748 LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 807
Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
E EAT + + +++ + + ED Q + +++ + I
Sbjct: 808 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 867
Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
++++ L PL E I K E +L A+ + I
Sbjct: 868 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 927
Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
+ P V K D++N Q+ N L L + SH + YL ++
Sbjct: 928 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 985
Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
D +R + K G +H Q + ++ FL+ +Q D+T L KE+
Sbjct: 986 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1041
Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
Y E K+ E+ L +++ + L++Q++ ++ D H
Sbjct: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101
Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
+ E + + + L T+ N +EF S + + +L + + N++
Sbjct: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161
Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
T L V +NT + + + K + E + + K +E + S
Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1214
Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
LK RS EK+ F E Q + + ++ L+ DW K D VE +
Sbjct: 1215 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1274
Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ ++ + +S+K D +++ Q ++ Q E + L TQL +
Sbjct: 1275 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1334
Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
K + +E EC E + L + Y A +D+ ++ + ++ + S
Sbjct: 1335 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1393
Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
++++F + Y+ S+K L +++SL+ + V +++K++
Sbjct: 1394 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1453
Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
++I K K KI E +S + + L Q+ +HG + +++ +
Sbjct: 1454 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1512
Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
+ +QV E F+ + ++Q+++ S ++ +++ + R + +E+ +
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
T+ + H + + G +++K+ ++E+ KN E N LK+
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1629
Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
E L E L+L+AE K+ D + +KE + A L E
Sbjct: 1630 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1689
Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
I L D ++ + H ++ + ++ EE + L T
Sbjct: 1690 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1749
Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
+ T E+L QYQ + V+ +TQ +Q L LE++ + + K +
Sbjct: 1750 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1806
Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
L E + A +E ++K H + Q+EL++ D+ + L +EL
Sbjct: 1807 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1862
Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
E D + L + R + F ++ + HK R + + E A S + +
Sbjct: 1863 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1916
Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
+ ++ V+ ++ + DR ++ KC +L LK + D D S L LQ
Sbjct: 1917 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 1975
Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
K L E I K L EE Q +S + ++KK EV+L A S
Sbjct: 1976 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2033
Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
+L + + K L D+I+ + + + EK + + + D L ++L
Sbjct: 2034 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
M +E S KE L+ QD + ++ + I + +N ++K D
Sbjct: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
A Q + S + A K +E ++ +++TK+ FE+L +L T ++ +T L
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2203
Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
+ L++Y +E+ + +E LE + ++ G P + + L K
Sbjct: 2204 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2262
Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
L ++D + EK ++S + +L L+ ++E K ++ +F A++
Sbjct: 2263 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2322
Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
+ LE+ K K++E +++ V +S S + +A+ ++ A+++
Sbjct: 2323 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
+T E + L ++ T E+ G+ L ++ L K L +A +E
Sbjct: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2437
Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
W +++ + +W+ + EA+ Q + E + +EL + L L
Sbjct: 2438 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2497
Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
+ + K Q L L + R + ++ + +TV A ++
Sbjct: 2498 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2557
Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
KE +L + + ++ T+ Q+ +E K ++Q T + Q + + + S +
Sbjct: 2558 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2617
Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
E+L ++ +K + + R + + + + +S + L D+D K+S+
Sbjct: 2618 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2675
Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
+ S+ AM +++E +++ +QQ+ K I+ AQ + + + + + K EL
Sbjct: 2676 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2730
Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
+++ I VEQ + + + Q+QQ+S+ + + + NK+ +
Sbjct: 2731 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2790
Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
K++ L+K E I +LL + L T+ +
Sbjct: 2791 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2850
Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
T ++ AL+ EQ L + +LE++ + E SI +
Sbjct: 2851 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2910
Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
L + + Q ++E L V I+ EV KS+ ++V + L SK+
Sbjct: 2911 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 2970
Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
+ ++ + EV E+ R ++ ++ L + QT K L +
Sbjct: 2971 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3030
Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
+L QD+ + +E + QE + L + V ++ + + +++ +
Sbjct: 3031 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3090
Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
N FS D+ D + + + E ++KQ I + ++ E L+
Sbjct: 3091 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3150
Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
L E+ G++RD L A++ + + +R A R+ G++ L +++E S
Sbjct: 3151 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3208
Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
+ +KAE +S + ME + TI Q+ +M ++
Sbjct: 3209 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3243
Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
+ + QG + + + + +T +E D D + L +V + + E
Sbjct: 3244 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303
Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
L C V EL Q + E + + A +Q Q L Q+L+ +
Sbjct: 3304 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3363
Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
E+ K+A E K + L EAL K +T LE + ++ Q+ H
Sbjct: 3364 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3421
Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
E L+P+N L+ +E + Q ++Q+ + K +E D
Sbjct: 3422 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3464
Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
I + +H + + SS E+ D+ S L D Q +
Sbjct: 3465 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3505
Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
E+ K L + + + V + N+ L ++ + S L
Sbjct: 3506 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3551
Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
Q+ TE L K+ EL + L +V++ L + +G +V L
Sbjct: 3552 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3607
Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
E +K Y ++ D+ K + + L + L L+ + + + G
Sbjct: 3608 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3667
Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
+ +++ Q K L + K+ +L SLNE+S + +A E E VA
Sbjct: 3668 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3717
Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
++ ER L + Q+V +++ + +A ELS ++TE+++ + G + L
Sbjct: 3718 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3774
Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
+ QT +++ +Q +I HK LV + ++ A S + S+ +
Sbjct: 3775 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3823
Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
+ T +I E+ Q + Q WE ++E + L + + +IS LP+ +L
Sbjct: 3824 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3882
Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
ET + E ++Q++ I + + G QL+ EL G+ ++E++
Sbjct: 3883 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3933
Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
++ L +I ++ + L +S + D++ + LES + + + Q ++S ++
Sbjct: 3934 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 3992
Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
+ I+ I+ S ++++ L + G +++ + A Q + +
Sbjct: 3993 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4046
Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
Q+ I E +H L E+ + E+ W +++ + +D+ + P S
Sbjct: 4047 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4106
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
VK + + R E+D Q +D V N ++ C K + + + E+N W
Sbjct: 4107 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4162
Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
++ +I LE+ +++ + ++ +Q + +W++ +L ++ + + K
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4218
Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
Q IE KS+A + + L A LL+ D EL S+
Sbjct: 4219 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4276
Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
++ + ++ L + DE+ + KPV + + ++
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4336
Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
LQ++ + + + E + + L + A ++ K + ++RW V + + Q+
Sbjct: 4337 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4396
Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
L+ K + HGE L+Q + + LA+ + G E L ++ +
Sbjct: 4397 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4452
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
+ K + +L R P+ AE++ + +++L +R LE+ L
Sbjct: 4453 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4508
Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
+ A EF L F ++ + E + LD + Q E+ F N V + Q
Sbjct: 4509 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4566
Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
+++ HL S K + V +K L ++ +W + +ER L K +
Sbjct: 4567 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4624
Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
E W +L+E +EE+ K +++AN ++ Q +K + + ++ D+
Sbjct: 4625 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682
Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
L + T + ++ + S+L D+W +R+ ++ + FT +++ L
Sbjct: 4683 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4742
Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
+L L+ E ++ L+ L + FQ+ +RT+ L+ + L+
Sbjct: 4743 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4797
Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
V ++ +L W+ + + +L ++Q F S V + + E
Sbjct: 4798 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4856
Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
R + ED L L + KE +K+LE+ A L + TM +
Sbjct: 4857 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4909
Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
+ + +K I + ++E++ +Q + L + E + L AWL E +
Sbjct: 4910 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 4969
Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
I + IE++ K + E F E ++ KQ + + K RAA+
Sbjct: 4970 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5017
Score = 155 bits (393), Expect = 1e-36
Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)
Query: 616 ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
++L + E +L E VE + ++ S+ISK L+ K + SK ++
Sbjct: 1423 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1482
Query: 669 ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
+ L + K D N L K+ K E FS + +
Sbjct: 1483 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1542
Query: 714 QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
++K EK E + E+ +L+ D+ +LIG E + ++ + E
Sbjct: 1543 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1601
Query: 768 ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
E K + E++ +E+ L+ + + +S ++ ++ K+ EAK K +
Sbjct: 1602 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1655
Query: 828 VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
+K + K L V + + ++EES+ ++E+ + + E G +
Sbjct: 1656 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1712
Query: 880 KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
KHK+ + + T K+ +E+ N+ E D+ + ++ +++ + +
Sbjct: 1713 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1772
Query: 935 LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
+ Q + I + + +L+ + Q ++ E+K + K L +E +E +L
Sbjct: 1773 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1832
Query: 994 HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
H ++ EEL E + L+ EQ++E L A +I+ + S +E
Sbjct: 1833 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1886
Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
I T S NR + +K D A ++ L +
Sbjct: 1887 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1944
Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
++ L+++Y Y D L LQ + + S LQ +L + +
Sbjct: 1945 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2004
Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
++ + ++ E + E + NDI+K D + R +L ++
Sbjct: 2005 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2059
Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
N R E L+ L L V+ S L +PL+ A+Q D I
Sbjct: 2060 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2112
Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
+++ QD +Q I N + E ++ P ++Q + +F +H+
Sbjct: 2113 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2171
Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
V+ E+ + L+ FL + L + + VT+LS + E
Sbjct: 2172 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2231
Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
K+ E L+K+ + H DK L + L FK+ E + TSC+ LDAF
Sbjct: 2232 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2291
Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
+ + + +E T++ +++ F +L K+++D + K LK P + V +
Sbjct: 2292 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2348
Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
SL L + + ++ N+ + + ++ + + +
Sbjct: 2349 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2408
Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
E+ L+ + + + L L++ Q S + +QK + + + +
Sbjct: 2409 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2468
Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
+E K E + V+K+ ++ L L + E P K+ +D +W ++N+ T
Sbjct: 2469 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528
Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
D + L + + ++ + +W EK L L L+ D L + Q +
Sbjct: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2587
Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
EF+ R + + L + + L + S+ ++ +T + + +L+G ++ + +
Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2645
Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
DQA + +SLL++LS S SL + T +EIQQ+
Sbjct: 2646 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2705
Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
Q K + L E+ + E +EL +Q E + F + ++H L
Sbjct: 2706 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2765
Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
++F W K + S +E ++ DF TL ++ ++ + +
Sbjct: 2766 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
++ + L L + + + R +L++SL++ L+ ++ L W+
Sbjct: 2826 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2885
Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
N E+ K +P GE + ++L ++ +Q F V LNN+ KE
Sbjct: 2886 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2945
Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
E + +I + + ++ + ++ E+ +E K
Sbjct: 2946 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3005
Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
+L T+ +S L H V K + + L+V E K
Sbjct: 3006 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3054
Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
+LL+ E A+ + + Q + ++ L I + + + S + ++L
Sbjct: 3055 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3114
Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
+ E + KE ++ L +L+ AL K+ + + DL + +
Sbjct: 3115 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3167
Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
+L++ Q N LL+ + + E+ IK L E S L++ +Q + EH+ Q
Sbjct: 3168 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3221
Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
V T++ F F + + E LQ Q+ N L L +S
Sbjct: 3222 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3266
Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
++TS+ G + DD+ + + K + R A ++ + C L S+L TE
Sbjct: 3267 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3326
Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
+ L +K +++ V+ QE +++L +D E+ K ++A + +
Sbjct: 3327 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
+ + Q S+ ++ E +N E +N+ LE +++ NE L IEK
Sbjct: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
E LE+ +K ++ HN IG S + L + + K S
Sbjct: 3442 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3501
Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
Q + + QE + ++ L + + ++ + +L+++ ++ + + S L
Sbjct: 3502 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3560
Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
W+ S V D L + + Q L +G E ++Q IQ K Y +
Sbjct: 3561 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3617
Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
T L V T +Q L RL S E +++ + VLKG
Sbjct: 3618 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3670
Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
QA+++ K + E K K L D +N + W E L + AE+ ++ I
Sbjct: 3671 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3730
Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
K++E + W +L I L D +Q++ K
Sbjct: 3731 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3790
Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
IL + ++ L + + + + E + L+ + Y + +++R QLE
Sbjct: 3791 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3850
Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
+ F+ + + E+++ II ++ A E E TL Q+E +++ I+
Sbjct: 3851 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3903
Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
H + + + EL+ E ++++ ++I+ ++ ++ I Q
Sbjct: 3904 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 3963
Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
FH+K + E S++R L Q + + E+ +K++++ K + + KL+ +++
Sbjct: 3964 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4018
Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
+ G + D S +LDQ+ T V E+E +L + ++ + F
Sbjct: 4019 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4078
Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
+H + + DL+ + V+K + E+ R L + ++ L E
Sbjct: 4079 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4138
Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
+I E D +K I ++ D L K ++ + +L QD L+
Sbjct: 4139 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4192
Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
++ +L I +++ ++ + + EA+Q+Q+ E + +A ++K
Sbjct: 4193 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4252
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
EE S+ V+ L E + + L I R + L A L +++ A+ + +T
Sbjct: 4253 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4310
Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
E ++ + VG +++E+ L K L++ V Q E + S+ E
Sbjct: 4311 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4369
Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
LQ L+ L + + E + ++ + + L K + ED+ L+ E L + +
Sbjct: 4370 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4429
Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
LP + +E L +E A + + K + K +Q+L RC ++ + + ++
Sbjct: 4430 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4485
Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
L EKW S+ E + EE W +E+ R ++ILD +
Sbjct: 4486 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4545
Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
++ E + + + E++ EL L Q + V + LL+++ + + +Q
Sbjct: 4546 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4605
Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
+ E +++ A+ ++ E K L ++ + + ++T++ + F
Sbjct: 4606 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4665
Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
K + A + + T + +++ + D+ + + EL Q+ L++
Sbjct: 4666 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4725
Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
L + L+ +Y + P E Q + L D + E+ K + S
Sbjct: 4726 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4785
Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
A++R E+ G + V+ +Q+ S E + L+ + E S V
Sbjct: 4786 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4845
Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
++E + G + D L Q+++ ++ E + ++LNKAT +
Sbjct: 4846 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4905
Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+ D + + + WI + + L H + AL K LL ++
Sbjct: 4906 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 4960
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
L+ TD+ + I + +V AL Q ME + + Q D V
Sbjct: 4961 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007
Score = 155 bits (392), Expect = 1e-36
Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)
Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
+L L+S+ ++L + ++ FS +++ Q Q+ +++ + +E Y +
Sbjct: 1008 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1067
Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
++++ N + D+ + QI + L E R++ Q+ K++ L
Sbjct: 1068 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1119
Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
KDD+ ++ +C++ + +S+ + LN +L++
Sbjct: 1120 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1167
Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
+ + + + V ++TQ + A+ KL E +++ + + + ++ + ++ DE+
Sbjct: 1168 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1225
Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
+ +ELQ D M + + +++ + K+ A + +E+ + ++
Sbjct: 1226 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1276
Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
+DN L+ L + K+ + +++ VE++ + + +E+
Sbjct: 1277 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1322
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
T L++ K ++ IE ++ + + E S V D + + +++SQ K
Sbjct: 1323 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1382
Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
+ I +++ Y TLM + D+ L+++++ L+ K
Sbjct: 1383 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1442
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
E+A +LQ S AE K + K+K + E+ ++ E L
Sbjct: 1443 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1492
Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
+ + L K + RN++++ + L S LL + L Q+++ + + D
Sbjct: 1493 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1544
Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
+ ++ V +E K+K+ LT E + + + + + K + ++L+
Sbjct: 1545 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1604
Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
++ + A + K + + QE + LI E EA++K + L+A Q
Sbjct: 1605 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1660
Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
+ +E+D ++T ++E T E++ QL+ K + + ++ N + E
Sbjct: 1661 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1710
Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
+Q E+ +E D N LL +V+ V NL + +K
Sbjct: 1711 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1770
Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
+++ + + Q Q E++++L++ +K+L E AL
Sbjct: 1771 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1825
Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
+ + L E+ D + L Q Q +E + D+I + KL K+F
Sbjct: 1826 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1883
Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
+ + + + D Y + N VLE + ++D +++ L
Sbjct: 1884 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933
Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
H ++ +S + ++ +K + ++ + E + A + + +A TA + E + +
Sbjct: 1934 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 1992
Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
+++ +L E + LQ Q+++ + VL DA +L K + + ++ I
Sbjct: 1993 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2048
Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
VG E+ + + E+L+ T+ +QD L E L + + E+ L+ Q
Sbjct: 2049 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099
Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
LQ+++SKN +++ +++ E K + + + ++L L
Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159
Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
S ++E L ++E+ K V + E KL+ L TE D G + ++
Sbjct: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2216
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
+ E LE K E+ LK+ S + + A++L+ NL ++ E+ T
Sbjct: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2273
Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
KEA T+ CQ E ++ Q+L+ L I+ + VP
Sbjct: 2274 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2312
Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
Q ++ K L+ +K +E + E I+L N TT + +A
Sbjct: 2313 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2371
Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
+ +E+F KG + + M + Y ++ ++ AE+ +++
Sbjct: 2372 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2426
Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
+ +KA E+ +K++ K + A E + + + + +N+ K
Sbjct: 2427 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2485
Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
QE++ K+ + L+ W L E+DS+ Q++ + D Q E N + FQ
Sbjct: 2486 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2545
Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
Q +Q E S Q + + ++E++ E
Sbjct: 2546 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+L+ P + SLR LS + A+ S Q +LL S+
Sbjct: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
L DL + + + NQ QK+ + + Q Q + +D+ A+ E
Sbjct: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725
Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
+ +++ IL S + + E H++H + + ++ + ++ + Q
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2785
Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
P+ + +LE++ ++ + K + Q++ +++ I + +L
Sbjct: 2786 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2828
Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
L+ ++A +L ++ + KQ+ N+ KE L + K V L + +
Sbjct: 2829 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2888
Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
Q +E + +E E +A+ + ++++ N S+ + +++EV
Sbjct: 2889 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2948
Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
KS D E+ ++ + K+ +E S S +Q A ++ D+
Sbjct: 2949 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3006
Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
+Q + L Q + SL+ + + + D +++SD++G + +VE E
Sbjct: 3007 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3066
Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
+ + + + LE LQ N E + A+ + L++Q
Sbjct: 3067 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3126
Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
+A L ++E +A +TCK ++ D + + EALS + L +
Sbjct: 3127 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3186
Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
E+V+ L+E +S+ + +IL + +E EH+E+ PV + E E+I Q + K F
Sbjct: 3187 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3241
Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
Q++++ L+ +Q +++ I+ AK Q +HD D T + A A
Sbjct: 3242 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3301
Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
E D +S+LS W EL + K P L
Sbjct: 3302 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3353
Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
+L++ + ST + IL +++ + R+ + +T QLE +
Sbjct: 3354 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3413
Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
A E ++K+L +Q S +EE + + +D H
Sbjct: 3414 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3471
Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
L+ A+S G LK ++ E+ +++ D QV Q + RS+ L
Sbjct: 3472 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3519
Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
+ L + + + L + L + L + S+ + S + + +Q + ++ +
Sbjct: 3520 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3579
Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
V + G L L EV ++D L++ ++ARY +++ S V ++ + AL
Sbjct: 3580 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3634
Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
L E L K+ E L++ + K + A QAQ+ +N+K L
Sbjct: 3635 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693
Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
V+ LL +++P W + K++ E + + + ++ QK EE D
Sbjct: 3694 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
A++ + + + +S + ETE++L+ ++ S Q+++ + R
Sbjct: 3739 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3795
Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
+++ G +++ + S E + KL+ + +N + +L R Q+L+
Sbjct: 3796 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3855
Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
+ ++L WL +Q ++ +L + +T+R + + + E
Sbjct: 3856 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3908
Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
+ G QLL L + +++ + ++ + + L + + I
Sbjct: 3909 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 3968
Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
+++ + + + S+ + ++K + ++K ++M+ Q + + + Q ++
Sbjct: 3969 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026
Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
+ D+ +K + + L +M W +H ++ + L ++E +
Sbjct: 4027 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4081
Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
L ++ ++ ++ L+ P SV K Q+ + + L E + L S
Sbjct: 4082 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4138
Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
+ + IDEL S+ ++++L+ +MQ+ +Q ++D V+
Sbjct: 4139 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4198
Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
+ + + P+ LET++ Q+E L+ + EA + E+L L K
Sbjct: 4199 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4254
Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
S +++ W + + I ++ K + L + +A E A L E
Sbjct: 4255 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4314
Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
+ + G+ A + A + LQ+DV Q T EA + + L E+S
Sbjct: 4315 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4369
Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
L L L QR + + + + + L Q K F +E L+ + E +L
Sbjct: 4370 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4427
Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
L + KE + + A A+ + L ++ + P S + + N+
Sbjct: 4428 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4487
Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
+W ER ++L+ + L +F + +I L + E+ L V S P L+
Sbjct: 4488 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4544
Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
+++ E +V N+ +S+ Q ++L T T ++ ++ + + L RW+
Sbjct: 4545 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4602
Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
VQ + +R +D ++ + F + L +L ++ L S ++ +T+ H+
Sbjct: 4603 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4662
Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
K + + + T G L T L + +S+L+D W + + E
Sbjct: 4663 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720
Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
+ + + Q ++ L L ++ Q + P +H D+ LI K ++ L
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4779
Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
T +++ L+ +L +D +K Q++ L +WE +C ++ +E L
Sbjct: 4780 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4838
Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
F+ L WL + E VL + ++ +I++ K+ M+++ +
Sbjct: 4839 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4897
Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
MGD ++ + I + I R++ + ++L A + + + L
Sbjct: 4898 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4957
Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
WL E+ L+ K V+ + +E++ +AE Q ++ + V+ V
Sbjct: 4958 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5015
Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
D + ++T+ ++ L +W+ + +++E
Sbjct: 5016 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5075
Query: 6127 RRMKIEE 6133
RR K+ +
Sbjct: 5076 RRRKLND 5082
Score = 146 bits (369), Expect = 6e-34
Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)
Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
P+ +AM P++ F++ P +E++ +E+ Y + E + + ++ H+L
Sbjct: 927 PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 982
Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
N RI S+ +S + Q L++LQ + +E ++ S +LE VN
Sbjct: 983 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1042
Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
K+ + ++ LK ERE Q + R+E+ E L ++ P+E+
Sbjct: 1043 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1098
Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
L H+ F + + +++ + L ++D + I N+ EE +
Sbjct: 1099 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1143
Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
L + N++L+ Q M+ D LK + L + + A+ + T L +
Sbjct: 1144 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
+A +N + T+K E+ H ++D KAK + K K D+ F
Sbjct: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
+ D E N+ +L + G G ++ + L+ I + + IQ+ Q
Sbjct: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
+ SK T+ +++K L+ ++ + +E +++ ++ + ++ KD +T+
Sbjct: 1321 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1371
Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
+ ++ K+ V Q L +++++ + ++ T L+ + Q
Sbjct: 1372 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1421
Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
++LK+ E + ++EE EH+E ++ + N+ L + +PPF K+
Sbjct: 1422 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1475
Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
+E+ E L AL I + K KM T+E+R L++++
Sbjct: 1476 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1518
Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
+ + E FS + ++Q S ++ +E +++ I + + + L
Sbjct: 1519 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1578
Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
G + T EL+ + + K G ++L + + +++ E KL + +
Sbjct: 1579 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1638
Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
+++QK L E +I C L + + KK+ + V +++ +L + K
Sbjct: 1639 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1694
Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
N DW SN+ + + F+ + K ++ ++ + + L
Sbjct: 1695 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1754
Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
T E N + ++V + ++ + + +++ GQ E+ E + Q KE
Sbjct: 1755 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1813
Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
L+ SLQ+ L D D+ WL E++ + +E +
Sbjct: 1814 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1873
Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
L R++ E V L+ + + +C
Sbjct: 1874 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933
Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
DR+++L + + + K L + Q + D +A D
Sbjct: 1934 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 1993
Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
+ ++++E+ + + E+++K E++L DAR + + + +Q
Sbjct: 1994 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2042
Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
KTL DI ++++ L+ + EKL + + L ++ L ML +E K++
Sbjct: 2043 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099
Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
L A I K + QD+ +S N + E K + +P
Sbjct: 2100 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2145
Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
SL +++D +H + +L T + +N S++ +F + +
Sbjct: 2146 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2205
Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
V E Q +QE + L+ + +L K + + + ++ + +L
Sbjct: 2206 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2265
Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
K K++E+ + K+ + C ++KS +S K+ +P + D+ +S
Sbjct: 2266 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2325
Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
+++ +KL+E W EI K A+ S LN + +
Sbjct: 2326 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2382
Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
NTE+ ++ + ++ + +L +L+++ E KL +A++ + ++
Sbjct: 2383 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2442
Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
+ +NKT T + +A+ T +++NK + E+ +
Sbjct: 2443 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2479
Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
K + + LK D +T L + + K L + KW+ L+ D +KL
Sbjct: 2480 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2535
Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
ES + Q ++ + Q +VE + +++ + L Q+Q +Q+ L+
Sbjct: 2536 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2589
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
R Q T G +L E + +++ + + ++W++L
Sbjct: 2590 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2634
Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
+ + I + +++ +++L + +L +L+ S+ + PD + Q+ +
Sbjct: 2635 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2694
Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
I ++ + ++L E++ V Y ++L+ LE + ++ + K+
Sbjct: 2695 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2752
Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
Q L+ F + R FQ + + E + K H ++ LE+
Sbjct: 2753 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2800
Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
K+ ++ ++ +H+ E T N+ + E+ L+ QL +K + + ++
Sbjct: 2801 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2860
Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
N+++ ++ ++ E+ L D Q N E+ + +G ++
Sbjct: 2861 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2920
Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
+ + + L +L V ++ K ++D + Q+ K+ LE ++
Sbjct: 2921 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 2980
Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
F+E + K Q +K +D+ ++ + ++++ + Q L +++ AK L
Sbjct: 2981 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3039
Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
+++ + +++K D +LQ++ A+E+ L + + L K + Q+ +
Sbjct: 3040 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3094
Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
+ +L + + + +Q +K+ +AF +++ A M S K
Sbjct: 3095 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3154
Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
+ D+ R+ E L Q N +D L + Y L + + +A
Sbjct: 3155 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3214
Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
E S P ++ + L M + ++EE+E QD+ G+I S
Sbjct: 3215 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3270
Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
Q +L N+ K K A + E + ++ + + LS M E V
Sbjct: 3271 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3330
Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
Q S ++ ++++ K L L K + +++ + D + +LK
Sbjct: 3331 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3388
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
+S L +W +LL A+ E + + E +E L +++ L E T+
Sbjct: 3389 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3448
Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
+ E++++ L D + + +++ + + + + + + E V++ F ++
Sbjct: 3449 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3503
Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
+ ++ +K EL+Q + F ++ + L N+ + ++ QD+ +
Sbjct: 3504 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3558
Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
+Q EL+ + + L +N+ + L + E I+ ++E + +DI
Sbjct: 3559 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3617
Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
K+S +V K+ + + R++ EE+ L VE L K + +AQ K
Sbjct: 3618 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3677
Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
++ E + L+ L+ ++E P +A+E ++ ++ ++Y+ VS + ++
Sbjct: 3678 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3737
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
+ A ++ +++ + +WI T L + D L ++ Q+ ++ + L
Sbjct: 3738 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3793
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
H + D+L +S ++ + + Q + + L ++ + D + I SE
Sbjct: 3794 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3842
Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
+ + +S++ L E EEH + E+I
Sbjct: 3843 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3902
Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
E +I M KT +++ P G + + L IK E+V +++ L
Sbjct: 3903 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3954
Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
I Q+ ++ ++I+ + + SLE + ++ + P + E+E++++QI
Sbjct: 3955 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4000
Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
+++ VD++ + L++ LKQ E
Sbjct: 4001 ENKNVSVDME-KLQPLYETLKQRGE 4024
Score = 90.9 bits (224), Expect = 4e-17
Identities = 379/2122 (17%), Positives = 783/2122 (36%), Gaps = 342/2122 (16%)
Query: 4938 RLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQ-----DLDTIRSNINNFF 4992
R L LL N +++ ++ Q LN+ E + + + DL ++ S++ N
Sbjct: 585 RKPLLKSSLLDQNLTEEEIN--MKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHK 642
Query: 4993 EFSKEVDE-KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
+ ++E +SSLK A IS LK T L + E ++ L+ + + L
Sbjct: 643 NVHRAIEEFESSLKEAKISEIQMTAPLK----LTYAEKLHRLESQYAKLLNTSRNQERHL 698
Query: 5052 HQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYK 5111
L SR A E+I W+N E + D ++ ++ K H E E+D K
Sbjct: 699 DTLH--NFVSR-ATNELI-WLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQK 751
Query: 5112 QWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQ---L 5168
+ + V + QL + R + M QW + + QH+++
Sbjct: 752 EENIKSVQEIAEQL----LLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 807
Query: 5169 LESITESENKIQILNNWLEAQE-----ERLKTLQKPESVISV----QKLLLDCQDIENQL 5219
E +++ L N +A + +R ++ K E ++ ++ LL + L
Sbjct: 808 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 867
Query: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEW 5279
K+K + +LK + PL + +++ + + ++ + S +W
Sbjct: 868 MGKAKTIIQLKP-----RNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKW 922
Query: 5280 KIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAE---SSEGSWEK 5336
K+ +E + ++ F + + V L+ + Q +N+ +L E+ S SW
Sbjct: 923 KVISPTGNEAMVPSVCFTVPPPNKEAVDLA-NRIEQQYQNVLTLWHESHINMKSVVSWHY 981
Query: 5337 LQEVIGKL--------KGLCPSVAEIIEEKCQNTHKRWTQVNQAI----ADQLQKAQSLL 5384
L I ++ K + P + + Q+ + + + +Q + + + +
Sbjct: 982 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1041
Query: 5385 QLWKAYSNAHGEAAARLKQQEAKFQ----QLANISMSGNN-----LAEILPPALQD---- 5431
+ K Y ++A R +Q+E+ + ++ NI + N + +I P +D
Sbjct: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101
Query: 5432 --------------IKELQHDV----QKTKEAFLQNSS-------------VLDRLPQP- 5459
++ L+ D+ K +E F Q ++ VL + Q
Sbjct: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161
Query: 5460 AESSTHM----LLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMH 5515
+ SST++ + L + Q A L K+ K E E V++ + + +LK
Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1221
Query: 5516 EEENLDRLHQQEKE-NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQ 5574
+E H E E ++ + T + D++ D + + +
Sbjct: 1222 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF-----------DWHKEKADQLVER 1270
Query: 5575 WIRATATALERCSELQGIGLNEKFL----YCCEKWIQLLEKIEEALKVDVANSLPELLEQ 5630
W R +L+GIG + K+ + + WIQ +E + ++ + + L Q
Sbjct: 1271 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1330
Query: 5631 QKTYKMLEAEVSINQTIADS---YVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQG 5687
KML +E+ + Q+ D Y Q + E++ + + D Q +
Sbjct: 1331 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT-----YRAMVDSQQKSPVK 1385
Query: 5688 VRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL--SAVKGQERFSLYQTRSLIHELK 5745
R+ + D +++++ D T L +T S + +E + H K
Sbjct: 1386 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1445
Query: 5746 NKEIHFQRRRTTCALTLEAGEKL---------LLTTDLKTK-ESVGRRISQLQ------- 5788
KE+ Q+ + + TL+ EK + + ++ TK E + + +Q
Sbjct: 1446 AKEL--QKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1503
Query: 5789 -----DSWKDMEPQL-----------AEMIKQFQSTVETWD-QCEKKI-----KELKSRL 5826
+ ++E Q+ +E +KQ Q + + D + E+KI +E K +L
Sbjct: 1504 DKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL 1563
Query: 5827 QV---LKAQSEDPL-------------PELHEDLHNEKELIKELEQSLASWTQNLKELQT 5870
Q L Q+E+ L EL + ++EL K+++ S + + +K +
Sbjct: 1564 QGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN 1623
Query: 5871 MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNK--- 5927
+ + ED ++++++ + E L L+ K+E+ D++ T + E K
Sbjct: 1624 FLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL-DKVVTTAIKEETEKVAA 1682
Query: 5928 ------------ELCAWLVQMENKVLQTADISIEEMIEK--------------------- 5954
L WL ++ K + A +++IE+
Sbjct: 1683 VKQLEESKTKIENLLDWLSNVD-KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN 1741
Query: 5955 ---LQKDCMEEINLFSENKLQ---------------------LKQMGDQLIKASNKSRAA 5990
L+ D ++ EN Q Q L++ + +
Sbjct: 1742 GNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1801
Query: 5991 EIDDKLNK-INDRWQHLFDVIGSRVKKLKETFAFIQQLDK---NMSNLRTWLARIESELS 6046
E +KL K + + H + KK+K T + ++L+K + + WL + E EL
Sbjct: 1802 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1861
Query: 6047 KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANET--ECD 6104
+ D + +L Q+ D+ H + + + +L + +C+ + D
Sbjct: 1862 N-LEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1920
Query: 6105 SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED-------WLKSAER 6157
+ T R + R+ + K + +D Y +ED L++ E
Sbjct: 1921 T-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA 1979
Query: 6158 TAACPNSSEVLYT--SAKEELKRFEAFQRQIHERLTQLELINKQYRRL--ARENRTDTAS 6213
TA+ S + + + +L+ +A Q QI + +E + K L AR + +
Sbjct: 1980 TASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2039
Query: 6214 RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWL--TEMDLQLTNV 6271
+++ + + R+++L + V +L+ + + + +L W+ E L+
Sbjct: 2040 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099
Query: 6272 EHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEEL-- 6329
+ + D + + +Q+I + I+ + ++ ++ ++P A ++ ++++L
Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159
Query: 6330 ------HRY------CQEVFGRVSRFHRRLTSCTPGLEDEKEA-SENETDMEDPREIQTD 6376
H++ +E+ +V F LE + +A +E + +D E+
Sbjct: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219
Query: 6377 SWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEE 6436
E E + H + G + + L + T ++ ED
Sbjct: 2220 MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-----LVLEKTNNLSKKFKEMEDTI 2274
Query: 6437 GPYYSALSDVE--------IPENPEAYLKMTTKTLKASS--------GKSISDGHSWHVP 6480
A++ + + ++ ++++K TTK + GKS+ D
Sbjct: 2275 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2334
Query: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNG----- 6535
S PE G ++ + A +TP K K G VLNG
Sbjct: 2335 WSLKTPEIQKVNNSGI-SLCNLISAVTTPAK----------AIAAVKSGGAVLNGEGTAT 2383
Query: 6536 NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIKQNLQQLNSDISAIT 6587
N ++ + GL I + + +E + + EL+ KL LQ+ + SA+
Sbjct: 2384 NTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS---KLQKAQEESSAMM 2440
Query: 6588 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQ-- 6645
WL+K + P+D + ++ +V++ + V + E L+
Sbjct: 2441 QWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN 2500
Query: 6646 TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
++PE+ + L ++ W+ + L +S F + L WL
Sbjct: 2501 PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLV---E 2557
Query: 6706 RRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIE 6764
+ V P DP L R+++ L +E R+PQ + L +L + + +
Sbjct: 2558 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2617
Query: 6765 --AEEKVHVIEKKLKQLREQVS 6784
+E++ + +K L Q+S
Sbjct: 2618 GIVKEQLAAVTQKWDSLTGQLS 2639
Score = 88.6 bits (218), Expect = 2e-16
Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)
Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
++LS G+ +QE++ + L L+ I ++ + I + + +I
Sbjct: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
+ P++ A + K + ++K+ YE K+ +EM A S KD
Sbjct: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
K V + V +WEN LV E + V+EL +++ + S++ T+ ++ + L
Sbjct: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4098
Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
+ + +K++ E ++EE + E +D + + L + ++P +K
Sbjct: 4099 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4155
Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
+ + W +N+ +D + L A+ + + + +W + A K+ D E
Sbjct: 4156 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4215
Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
+K++++ +Q SE ++ E++ L +E+ L+ ES L +++ + L
Sbjct: 4216 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4275
Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
+ H L G + + + LD+ + TE LL P ++E +
Sbjct: 4276 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4335
Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
+LQ K L+E+ G L +L L +++++V + +K L
Sbjct: 4336 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395
Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
+K + + ++ W ++ + +L K ET K EQ + E +
Sbjct: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4453
Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
K + + + PK+ + + + + E +E+ R +LE++L +
Sbjct: 4454 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4513
Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
+ ++ WLT E+ P ++ ++F + REQ + +
Sbjct: 4514 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4573
Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
LK F++++++++ L+ R++ ++++L E + F++ ++
Sbjct: 4574 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4631
Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
W++E ++SL + ++ + KIK + E + ++ + L
Sbjct: 4632 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685
Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
+KT L+++ ++WD + + E+ LL ++ + + L L
Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4745
Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
++ + + + + +K F K+ TS ++ LK L+E ++ + S+
Sbjct: 4746 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4805
Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
+ E+ E++ L+ +R+ + + V L L +
Sbjct: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865
Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
P D+ A+ + + +E +L + L K +LA+ T II+
Sbjct: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
+ + K + RLAS AKQE +E L + ++ + K K +P ++ +
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
+ +E T++ V+K+ + ++
Sbjct: 4986 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5012
Score = 58.2 bits (139), Expect = 3e-07
Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)
Query: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4707 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4764
Query: 6613 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6672
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4765 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4824
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6731
S + L +L Q ++FH + LL WLA A+ R + D + R L++ +E M
Sbjct: 4825 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4883
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6779
K+L E++ +++ + +++L H + + + +I + +++
Sbjct: 4884 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4929
Score = 53.5 bits (127), Expect = 7e-06
Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)
Query: 6571 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6627
K+++ +Q Q + A+ W+ +L M+ +D++ ++ +++ L++
Sbjct: 4175 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4232
Query: 6628 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6685
+ + +N ++ L+ TE + +Q L +L L+W++ + + + + L +L+
Sbjct: 4233 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292
Query: 6686 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6743
F LL WL + QK DPKA L + L+ +++ Q V
Sbjct: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4348
Query: 6744 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6797
+ + + N L+ GE+ + K+ V+ ++ + + E+ Q L G A
Sbjct: 4349 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4402
Score = 45.4 bits (106), Expect = 0.002
Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)
Query: 585 LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
L W T+ E L + + K EI+ L L H + +N+AGN L+E S
Sbjct: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362
Query: 640 NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
S++ +L LN+RW+ ++ KT+ +KQ L +
Sbjct: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4404
Query: 700 FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
F ++ E+ Q + E+H ++ G + AK E+L +E+ A EAK
Sbjct: 4405 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4453
Query: 759 QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
EE+ K L+ KG M +E + DI N+ +E ++ V + K+
Sbjct: 4454 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4498
Query: 818 EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
E K K++ L++ ++ S ++ +++ +A+Q L P +
Sbjct: 4499 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541
Query: 878 -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
I +HK + S+ + + + K LK + + ++ V ++WE
Sbjct: 4542 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4601
Query: 929 LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
+ VQ+L +E+G+ D+ K KQ ++ KL+ K L E E
Sbjct: 4602 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4651
Query: 986 EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
+ QL H E + L + + R LK+
Sbjct: 4652 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4687
Score = 43.9 bits (102), Expect = 0.006
Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)
Query: 6564 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6623
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2753 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2807
Query: 6624 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6681
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2808 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2866
Query: 6682 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6741
SL + + + + L W+ +N ++ DP +L L+KE+ +
Sbjct: 2867 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2923
Query: 6742 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6801
V++L +NSLL + + +E +I+ K+ + EQ+ L +N
Sbjct: 2924 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 2979
Query: 6802 SFDEV 6806
F EV
Sbjct: 2980 EFQEV 2984
Score = 41.6 bits (96), Expect = 0.028
Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
W+ ++ + ++ + K++ L Q + + WL TE +L KP D + IE
Sbjct: 4272 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4328
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
+ + + + +++ V +VN + + +++ + E++ LQ++L L+ W+
Sbjct: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ + L +L Q + FH ++L WL + H+ K L E +E + +
Sbjct: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4442
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6778
E+ + +E SL+ KG +D +EK +E KL +
Sbjct: 4443 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
Query: 6779 LREQVSQDL 6787
+ ++ + L
Sbjct: 4500 RKTKLEEAL 4508
Score = 40.0 bits (92), Expect = 0.080
Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 8/153 (5%)
Query: 6557 RWEMIQAQELHNKLKIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 6613
RW+ + + K ++ L+Q + +I + WL TE L K + + +
Sbjct: 4380 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4439
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGA 6671
L V E+ AF+ + S+ ++ L P+S E + + L WE+ +
Sbjct: 4440 LNVH--MEVCAAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETK 4496
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6704
++ + L ++L +FH Q+ + WL A+
Sbjct: 4497 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4529
Score = 38.9 bits (89), Expect = 0.18
Identities = 45/216 (20%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 6577 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6634
QQ + A +W+ +TE +L L + D +L+V++ EIL+ D LV
Sbjct: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3804
Query: 6635 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6694
S K E ++ +L ++ ++ L ++ F + +
Sbjct: 3805 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861
Query: 6695 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6754
L WL ++ + + P + L + + E QL + + E +P +D + + LL
Sbjct: 3862 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3919
Query: 6755 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL 6790
GE +EK + Q++E V + +AL
Sbjct: 3920 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVAL 3954
Score = 37.0 bits (84), Expect = 0.68
Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)
Query: 6558 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6610
W + ++ H++ ++ Q N + D + WL + +L L + ++ Q
Sbjct: 3504 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3563
Query: 6611 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6670
+ ELRV + +L+ + +AL+ + + QT E +Q +L + ++
Sbjct: 3564 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3619
Query: 6671 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6730
L Q+L + H + L WL + K + + + R +
Sbjct: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3677
Query: 6731 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6783
+L+KE + +D L E+S++LL +G + E E+ ++ + Q E++
Sbjct: 3678 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3737
Query: 6784 SQDLMALQ 6791
++ Q
Sbjct: 3738 DAAILRSQ 3745
Score = 36.2 bits (82), Expect = 1.2
Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)
Query: 310 KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
K+++++L K +++ Y ++ ME N + + L ++ + D + ++L+
Sbjct: 4218 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4271
Query: 370 WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
WD L+ +I + KL AL L + AWL E L+ E D +A+ +
Sbjct: 4272 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4330
Query: 423 ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
+Q + +S ++ N L+ +E ++L NKLE + +R N+LE
Sbjct: 4331 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4386
Query: 476 K 476
K
Sbjct: 4387 K 4387
Score = 33.5 bits (75), Expect = 7.5
Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)
Query: 6647 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6706
+S + L+ L ++ W+ V L+++L+ C F ++LL W+ +
Sbjct: 3269 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3326
Query: 6707 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6766
A+ P A+ + + +E L++ L +R+ V++++ + D ++
Sbjct: 3327 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3386
Query: 6767 EKVHVIEKKLKQLREQVSQDLMALQG 6792
+++ +++ + + L + L+G
Sbjct: 3387 KQLSLLDSRWEALLNKAETRNRQLEG 3412
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 234 bits (596), Expect = 3e-60
Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)
Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
+N I + + S K LPG +Q S++Q E +QES + +LE++
Sbjct: 657 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 716
Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
+ K E+ S + N + ++N ED R + +++ PLE D +
Sbjct: 717 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 774
Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
+ ++ E EKL +LE K + + E ++ + +VL N+
Sbjct: 775 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 834
Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
S+ ++D L + LK N ++ +++ ++ L E A++ DK +++
Sbjct: 835 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 883
Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
+ +K++ + +++++ L+ + + +M K E + QL
Sbjct: 884 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 942
Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
W+ V QI + + + + +DT L Q ++ + +E S
Sbjct: 943 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 998
Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
L T L K S E++MK+ ++ +K E +K +
Sbjct: 999 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051
Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
+Q K R +M+ + +L L + + K D + ++ +S
Sbjct: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1108
Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
L EE K+ V + S+++ TL+D + K S+++ K E+ S
Sbjct: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
I+ F +QES L+ + +++ + T ++K +
Sbjct: 1169 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1228
Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
Q+E +E GI L + N + E + D +LK + + +Q+ +Q +
Sbjct: 1229 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1286
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
+ +K F L+E + + Q ++ L+ Q++N+ +K E NLK D
Sbjct: 1287 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1340
Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
++ TAIK + Q+ + K + + L+W S +D+ + K K++ I+Q
Sbjct: 1341 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1395
Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
T F+E GK AI + + ++ D + + N L+Q+ +K K
Sbjct: 1396 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1444
Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
++II ++++ + + ++L K L+ EE +KL K ++ + + E + E ++
Sbjct: 1445 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1501
Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
K + Q++LE + + LQQ L NLE I + + ++F E V
Sbjct: 1502 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1561
Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
+ ++ +T + + + S+ +V+ KL D L + +
Sbjct: 1562 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1621
Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
+ N L D + Y++A + + + EA + P VD N + LE Q
Sbjct: 1622 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 1681
Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
++ S ++ L + ++ S AK +Q TL ++V + + ++ + + +
Sbjct: 1682 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 1741
Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
L + +++ + +E+ L + +PL+ + + ++ L ++ +
Sbjct: 1742 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 1800
Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
+ + + ++ + L + L ++ KE EELK + +
Sbjct: 1801 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 1857
Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
+ +NL E+L +TK A TE ELS+ + + ++ E+ + +
Sbjct: 1858 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 1909
Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
+L +LL + S +P V ++ ++ ++ ++ +++ KE V + ++
Sbjct: 1910 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 1962
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
+F + +LK++ ++TT + E + E+ + + +K L I +
Sbjct: 1963 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2022
Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
I + + V PA+ + V+ L + +E +N+ L S S Y
Sbjct: 2023 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2082
Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
++ KI E+N L ++K ++ S ++ Q++ K W
Sbjct: 2083 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2142
Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
EL +K+ EL ++ +++E++P +A W L ++Q+++Q
Sbjct: 2143 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2202
Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
R +L +++ + ++ + + W+ +++ P D L+ VQ+ L+
Sbjct: 2203 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2261
Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
+ + + + LS E L ++E VT + L D
Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2321
Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
+ ++ +S+ + +S + L +K + H LE + MK+ I
Sbjct: 2322 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2374
Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
Q K + V Q + L + E + E + L+ ++K + +++ EN Q
Sbjct: 2375 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2428
Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
L + A + MS D L + E + L+ E L+ D K + L
Sbjct: 2429 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2487
Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
H+ ++ + L E + + K N + E +++ES K+
Sbjct: 2488 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2547
Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
E+ E W + K ++EE + + +NS+A++ SL
Sbjct: 2548 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2590
Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E + N T E D +D L +V+ TE LH+ K +
Sbjct: 2591 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 2646
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
+ Q+ E Q E+ + L+ K+Q + D+
Sbjct: 2647 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 2678
Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
+Q + L+T + +L+ K Q+ L ++ ++D ++ ++S+ + + L
Sbjct: 2679 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 2730
Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
++E+I E S+Q D ++ LE K F I ++M+ Q+ + D++
Sbjct: 2731 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 2784
Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
++P G++ + Q + + +K +E +++N
Sbjct: 2785 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 2821
Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
+ M T+ +L LE L ++ + L + EE K+L E + L +
Sbjct: 2822 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 2880
Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
+L+ + E + ET+ +L + ++ L + + W G+
Sbjct: 2881 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 2937
Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
+T L D++ + R+ L+ L + +Q+ ++ L ++
Sbjct: 2938 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 2997
Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
++ + Q + V Q+Q+ L++ +S V ++ EGE++ +V
Sbjct: 2998 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057
Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
L+ + LDS W L R +L V Q L+ + E + +++L +
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117
Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
+Q AL+ I NH + V+ ++ S++ ++Q++ F
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3175
Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
QV ++I +EKS LQ L + F E+ L L + L +S+ + + E L
Sbjct: 3176 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3234
Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
++ S + ++ +I + + Q L G +L+ + E ++ ++ ++ ++ + K
Sbjct: 3235 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3294
Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
L+ L+ + ++L WL+ + L ++ Q L + +R
Sbjct: 3295 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3351
Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
E KE +L ++ + + LL L L +A+ +++ ++ + E
Sbjct: 3352 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3409
Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
++ + +A +SW+ E + + + + LQ K F ME +
Sbjct: 3410 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3467
Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
+K I D V ++ C E K+ + + + L E Q R ++
Sbjct: 3468 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3527
Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
N+ + E+L +TE+++ I + L A +TL Q+ E +++L+ + + +
Sbjct: 3528 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3583
Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
++ L EL ++ Y+ ++ + ED R +DE + + +++
Sbjct: 3584 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3643
Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
Q+ S++ +++ + + EV + + + +K V + +E L+ E L+ +E
Sbjct: 3644 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 3699
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
+ G +K A+ +++K W ++ + ++ K +++L
Sbjct: 3700 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 3747
Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
+ + H +K + + L + + + + + A + I+E +Q+ +
Sbjct: 3748 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 3806
Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
+ S L +P + L SL +A LE+ +
Sbjct: 3807 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 3866
Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
F++V L+ G LE++K I ++ +QQ+ E LNH L
Sbjct: 3867 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 3922
Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
++ + E S K + D L + W + R +L+G L +F + +
Sbjct: 3923 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 3975
Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
+ + L E L P+ +E + + +L+ +V +Q+ ++ L+++
Sbjct: 3976 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4035
Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
+ E + L RWQN ++ QRK +DG +RQ + F +E+L ++LTDT
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095
Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
L A K L E N + F+ + T ++ G+++L +
Sbjct: 4096 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4150
Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
++ + I+ L++ W+ +E +L E + + + E + + I L Q L S
Sbjct: 4151 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4210
Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
L + + + + + K + S + + EL L +DV+++K +
Sbjct: 4211 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4268
Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
+ +WE + R+ R + ++D F+E +L WL + E + +I+ +
Sbjct: 4269 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4328
Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
K Q K+ + + + G L K S ++DD L+++ D+W +
Sbjct: 4329 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4388
Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
R KL+E F Q + L WL R+E +L+ +PV D+ + +
Sbjct: 4389 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4445
Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
+ Q+++ + ++ V+++ L+ S + ++ + L RW +CA+S+
Sbjct: 4446 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4500
Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
++ ++E R ++F +WL AE+T P+ + L T + + + F
Sbjct: 4501 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4556
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+++ E+ +L + D+ + +K + R++ + +RL
Sbjct: 4557 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4616
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
+ E++L WL + LT+ + ++++ L F +E+T
Sbjct: 4617 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 4676
Query: 6299 KIDQL 6303
+D++
Sbjct: 4677 DVDKV 4681
Score = 193 bits (490), Expect = 6e-48
Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)
Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
N EE N FV L+ D +Q ++ + + ++ ++ +A+E+F +SL+
Sbjct: 271 NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 330
Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
AK+ S+ Q+ LT K +H ++ + K+L+ S ++ ER
Sbjct: 331 EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 370
Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
DT + A + I L+E V +++E N + + EL++ NI+
Sbjct: 371 HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 430
Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
VQ ++ L++ + +R + +L + ++H++E F D +E
Sbjct: 431 SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 490
Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
T C + + + LV E +E+ +L+ N T+I
Sbjct: 491 ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
Q S L+ S K R EI I K++ N H K +
Sbjct: 550 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 606
Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
+ F PP KEA +D+ + E Y+N+ L LW + N+K+V+ W
Sbjct: 607 MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 654
Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
+ + E DR R + E + ++ +Q + E E QV S
Sbjct: 655 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 706
Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
+ ++E V C + ++L ++ + ES+ L S+ I
Sbjct: 707 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 751
Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
+LE + ++++Q + + L + +T E +LKK+ E + D T + ++ FS+
Sbjct: 752 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 810
Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
+ + + N+ + + S T K+K V+ V
Sbjct: 811 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 851
Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
LK+ + + L K + +L ++ + +E + S + E+++ Q L+D+
Sbjct: 852 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 909
Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
L+K +E +K +E + + + E++++V Q++N L++ G + +
Sbjct: 910 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 968
Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
+ +D + +T R++ E + E K L T+ L ++ E+K+S M
Sbjct: 969 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1022
Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
E + E+ +K+ L A +++ + ++ S A L+ + D+
Sbjct: 1023 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1079
Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
++ + L + Y L +EK L E +K +++ ++L+ + LK ++
Sbjct: 1080 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1139
Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
AG + ++ K+ L +A L L G+ + + +N + L+
Sbjct: 1140 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1197
Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
+ L L+QLQ+S + D V +E+ + DL T +N +E
Sbjct: 1198 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1257
Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
D V+ + K ++LQ+ G+ + + + K+ + G+K+ ++D
Sbjct: 1258 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1310
Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
K+L +E +L AK + C LK+++S ++ +K T+ ++E T++
Sbjct: 1311 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1353
Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
AAV++LEE DW N D E A +K + Q +S EDE
Sbjct: 1354 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1413
Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
N L+ ++D + Q E + + Y +++A+ I Q + T++ ++L
Sbjct: 1414 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1468
Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
G S + + L + + LK + E+ LA E MK + +E L+
Sbjct: 1469 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1518
Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
D + L + ++ + ++E D + L K E++ +H +T ++
Sbjct: 1519 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1578
Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
LE+ + +V+ +++Q+K + + N + + L + QH
Sbjct: 1579 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 1638
Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
L L++ E A + D LQ L+GQ Q + K+
Sbjct: 1639 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 1698
Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
K +++ ++++ ++E L E ++ + +++ + E +
Sbjct: 1699 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 1758
Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
W N+ L +PL + I K + I RQ S+ ++ E+VK + +
Sbjct: 1759 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 1818
Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
S L ++DL ++ K + ++E +L+ + F + + E++T +
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 1877
Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
V+ + +E H LE L+EI S G+ + + + E+
Sbjct: 1878 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 1934
Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
N + F +ED +K K Q + V+ + ++ +K +Q
Sbjct: 1935 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 1994
Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
E+ +Q L E+ N G+ + NL +T I V V +
Sbjct: 1995 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2052
Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
G N + + + T + ++ L++KI +L+T + K Q +
Sbjct: 2053 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2109
Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
A+ ++KM + K A + E + L Q + K + L D++ +
Sbjct: 2110 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2169
Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
L EN ++ + K++L E D ++ L + ++ K + N + +T
Sbjct: 2170 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2223
Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
L Q ++ +L +L ++++ + ++ + ++ + +TA I +
Sbjct: 2224 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2283
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
E+ S V+ +L L + R + ++ A T+Y+ + + ++ L
Sbjct: 2284 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2343
Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
+ ++ + D N + LE + ++E++ I Q L E L A +
Sbjct: 2344 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2395
Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
+ +Y EL + + ++FK E +AE ++++ + +++M D + ++T
Sbjct: 2396 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2452
Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
+ S P+S + + LE L + SK L + ++ + + + LL+ + +E
Sbjct: 2453 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2510
Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
+ L L + W+ K+ +E W C+ +E K
Sbjct: 2511 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2570
Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
F + E E I L +LQ+E+ + + + + T+E L+
Sbjct: 2571 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2630
Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
+ E + ++ L + Q+ + Q V + S A E + + S +
Sbjct: 2631 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 2690
Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
+LQ QK+ + ++ ++ ++++ + + T+ + Q+H S+Q +E
Sbjct: 2691 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 2750
Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
S L+ +G F+N + ++ +++E + A + E +K E I + E
Sbjct: 2751 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 2810
Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
L +S A M EE + L ++E + +Q +K +++AQ ++++
Sbjct: 2811 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 2870
Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
L+ ++SKL E +Q E + Q M+ I P Q QQ
Sbjct: 2871 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 2930
Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
++++ R +QL +A + + D L+
Sbjct: 2931 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 2990
Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
S +W+ +T L+AN A++ ++ +Q L+D + + + I + E +
Sbjct: 2991 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3047
Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
+ E + + +++LS ++ AL K Q++ ++ ++ + + ++
Sbjct: 3048 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3107
Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
I+ L++ E EE + + + ++I K + + VS L++ +
Sbjct: 3108 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3167
Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
V + + ++ + ++ELL+ + + E+ L LN + S +
Sbjct: 3168 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3227
Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
+ L + Q E+ +++ IL Q + L++ LK T + ++ + E + +
Sbjct: 3228 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3286
Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
R +T VA+ +L RR ++L VE E+ + G+E +A
Sbjct: 3287 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3346
Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
+ P+ K++K + + SS + +E K+ DN ++++ +
Sbjct: 3347 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3406
Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
E+ LR Q ++ ++DA+ EK +
Sbjct: 3407 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3443
Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
++ L Q + ++ +Q+ +++ + ++ ++ ++ C ++
Sbjct: 3444 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3490
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
E +++ KL V N + + + E++ + + L ++E L P L+E
Sbjct: 3491 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3544
Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
+SI+++ P + RQ+ + +Q+ EL E K I K PQ + +
Sbjct: 3545 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3599
Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
+ QE +A S + DV D +S Q DK + L + +L P
Sbjct: 3600 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3659
Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
+ ++ Q+S N + + Y T ++ K +
Sbjct: 3660 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 3719
Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
L+ + N+ T E ++ L +K + L +T+ + + LE P +
Sbjct: 3720 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 3778
Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
QQ ET+ E+ L L + +L+ A P + ++ + D L
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 3836
Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
+ A R L+ + YQ+ ++ ++ + + S + + L + Q
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 3896
Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
+ K++AY ++E AE + K+ +E ++ + + + +L+ + DS+
Sbjct: 3897 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 3952
Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
+ R +L + Q Q AL + + L + ++K G K + ++A ++
Sbjct: 3953 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4012
Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
N + Q V A LI++ SA S LQN+ ++ V EK+ Q +
Sbjct: 4013 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4068
Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
L L++ + F L++ L L+++ P L E +E+L + + ++
Sbjct: 4069 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4124
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
K + +G+Q++A CP+ ++ I L+E+W S+ K++ +L+ L
Sbjct: 4125 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4182
Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
+ ++ WL ++ TLN SL LDT+ I+ F+ EV +S
Sbjct: 4183 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4235
Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
+ +I + HLK + D ++ L + +W ++ +L + L +
Sbjct: 4236 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4295
Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
+A ++++ W+ E + S + + + ++K L +HKEF+ + K + D N
Sbjct: 4296 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4353
Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
++ L + S + + + L E+ +W + G + LE+ L + + +
Sbjct: 4354 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4411
Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
Q L +WL E +L Q I V L+ + + + +L ++ ++ LK+S L
Sbjct: 4412 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4471
Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
G+ D +S + Q+ S+ V L S Q+ L+ + + V + +
Sbjct: 4472 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4525
Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
+ ++ + L + L++L D+ + E+ + + K + +V I
Sbjct: 4526 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4584
Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
T K W + +A +++ Q A + A A L + + Q A +++
Sbjct: 4585 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 4644
Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
+ E++P ++++K L + Q E + +D++
Sbjct: 4645 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681
Score = 179 bits (455), Expect = 7e-44
Identities = 674/3683 (18%), Positives = 1386/3683 (37%), Gaps = 526/3683 (14%)
Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
E +LEN+K + E+ ++L + + Q + L L+Y E L RLE A L++T
Sbjct: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 365
Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
+ L R T +W E A +W + ++ K
Sbjct: 366 RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 414
Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
E+ RE LD +E + + + E E L + Y ++ Q + L Q
Sbjct: 415 HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 470
Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
+ Q++ E++ E +E T +Q+ + K ++LVQ ++E+
Sbjct: 471 VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 528
Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
+ + N + T Q P S+ K + + I + +I+
Sbjct: 529 EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 576
Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
TI + +A + NE + S + + N ++
Sbjct: 577 I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 628
Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
++Q+ +N+ + WH +NE+D S V I PG+ Q+ + NL
Sbjct: 629 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 688
Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
F+ + + SQ ++ + +QL K V + Y +LLKS E + S ++ +
Sbjct: 689 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 748
Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
+R L + + + ++ +L S+F E + E + L + ++N+
Sbjct: 749 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 808
Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
Q S+P ++ + V+ ++V SM + K+KT+ L + E E
Sbjct: 809 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 868
Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
L E ++ + ++ I+ + ++ E+ + VF LQ K + +
Sbjct: 869 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 918
Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
E+ K ++ ++D E Q++ + H+ D ++L L+G I + K
Sbjct: 919 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 969
Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
+D + ++ T + +++ Q + + ++ V+E + + K++
Sbjct: 970 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
++ + Y A V++ E++ + ++ ++ P ++ R SS+ I+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1071
Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
QE + + T ++ ++T DSL + E SL +
Sbjct: 1072 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1130
Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
E+ PP + S + E E T E E+
Sbjct: 1131 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1190
Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
KT L ++ +V VE E + A+ QQ +++L G +LT+ E
Sbjct: 1191 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1249
Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
H+ AF++ E K Q + Q + + + L V N E EK S
Sbjct: 1250 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1307
Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
++ I +K +E + + + +NL EL+ +VT + +K +Q+ E K
Sbjct: 1308 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1365
Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
+ D++ ++ ++++ ++ Q N T + A E++V N
Sbjct: 1366 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1415
Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
G+ L+E V +G TTQ E+L
Sbjct: 1416 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1434
Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
Q+ ++ Q +++ + + + ++ L S EE ++ + +E +V
Sbjct: 1435 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1490
Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
HYET LA S+KK L ++ LE FD EH + +
Sbjct: 1491 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1535
Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
+L+AG D ++KR +I K L+ ISG V A+ K D V
Sbjct: 1536 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1593
Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
+ V + D +R Y+ + L+D++D Y + S +
Sbjct: 1594 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 1648
Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
Q + + + E + + + L L++TK ALQ QI + +V +KL ++
Sbjct: 1649 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 1704
Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
+LP+ ++T + V + L + + KLQ L + + + +
Sbjct: 1705 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 1763
Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
+ S+L V L + IS ++++I G+ + + + K+ + + +
Sbjct: 1764 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 1823
Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
L+ ++ L ++ + K L +++ L + + S++L +LE+ L
Sbjct: 1824 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 1883
Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
+V++ ++ + + F E K ++ SL + S H +D A +
Sbjct: 1884 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 1937
Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
+K+ + + + +E + Q + + + + SW+ +T+ + + PS A
Sbjct: 1938 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 1993
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
+ L+ K+ + + K + VN S + L + + E
Sbjct: 1994 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2053
Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
EF + G +++ + + +L KI L L + +++ + +
Sbjct: 2054 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2113
Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
WL+ + Q+ P +V+ + + E +L + ELK L
Sbjct: 2114 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2173
Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
++ P + + ID +Q+ R L + + T Q+V L++W + +
Sbjct: 2174 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2233
Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
L V P+ + L Q + +Q L E + + +E+L Q +
Sbjct: 2234 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2280
Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
+ + G PS+ I++E+ ++W + ++D+ + Y + + +
Sbjct: 2281 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2339
Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
L + K +S + + + L A + +E+Q + ++ K +A ++ S L + +
Sbjct: 2340 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2398
Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
++ L G L S Q+A +++ + A+ +F +DF L++ K
Sbjct: 2399 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2454
Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
EE+N LD L K++ D LTAQS E + LK S
Sbjct: 2455 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2508
Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
+ A LQ + W ER ++L+ EK L E+ WI +
Sbjct: 2509 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2566
Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
E +K + NS+ +L QK V + A+S LL EI+
Sbjct: 2567 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2617
Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
E +T+ +K L + + + +K ++ + +++++F + R L L
Sbjct: 2618 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 2677
Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
++ Q + Y T + + + K + + + A L A + ++ +D K V ++
Sbjct: 2678 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 2733
Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
+ + Q+ E ++ ++ + I+E+ S+ + S P+ E
Sbjct: 2734 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 2793
Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
L +KE IK + L A N +T K L D++ +K +E L +Q L
Sbjct: 2794 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 2853
Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
R R++++E + F K KE L + E + +E M +
Sbjct: 2854 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 2913
Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
QK EEI + + +G LI+++ KS + + ++ L+ +N RW+ L +
Sbjct: 2914 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 2970
Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
R +L+E + + +L +W+ E EL + + ++ ++ EQ+ LQR
Sbjct: 2971 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3029
Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
++ + VE V+ + + A E D ++ + LD RW + + R
Sbjct: 3030 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3082
Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
++E + Q+F + +WL + E+ + +E++ + +A + I
Sbjct: 3083 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3142
Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
++ L Q I + + L+ RE++ S+L + +Q W +Q + + L+
Sbjct: 3143 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3197
Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
+ F ++ WL E+ +L+ +V+ +S + +L Q++I L +DQ
Sbjct: 3198 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3257
Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
++ G +L++++ + ++I+D+LE + +++ + + RRL S
Sbjct: 3258 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3317
Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
CT + E E ET + P+E++ ++ + + + S +
Sbjct: 3318 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3377
Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLK 6457
P R G E V+ D+ + D E D + L + + +A L
Sbjct: 3378 VPWRAREGLEKMVAEDN--ERYRLVSDTITQKVEEIDA-----AILRSQQFDQAADAELS 3430
Query: 6458 MTTKTLKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKL 6517
T+T K K +S G ++E D+ + + + K
Sbjct: 3431 WITETEK----KLMSLGDI---------------RLEQDQTSAQLQVQKTFTMEILRHKD 3471
Query: 6518 LLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQ 6577
++ D K G +++ ++E + ++ +D I ++ + + +
Sbjct: 3472 II---DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3528
Query: 6578 QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVN 6637
Q + WL +T++ + L P + + + + + +++ + +K + +N
Sbjct: 3529 QFWETYEELWPWLTETQSIISQL--PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3586
Query: 6638 VSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLL 6697
+ + L+ E +Q + L+ + V L +++ Q FH +L
Sbjct: 3587 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 3646
Query: 6698 LWLASAKNR-RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 6756
L R RQ ++ A+ + E E + ++ + QP + L++ ++ +
Sbjct: 3647 ESLERIVERLRQPPSIS---AEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 3703
Query: 6757 GHGEDCIEAEEKVHVIEKKLKQL 6779
G D + ++ KL Q+
Sbjct: 3704 SGGTD---KDISAKAVQDKLDQM 3723
Score = 174 bits (440), Expect = 4e-42
Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)
Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
LQ Q E K F +KL A ++ + K +L ET + V + LE S+QC
Sbjct: 2795 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 2851
Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
LL + + +E K LE S L S+ L+++ +++ + +G +
Sbjct: 2852 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 2901
Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
+ Q LN +GKQ S S LE + + +W
Sbjct: 2902 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 2961
Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
+LNKK+ +LQ L H + + L W+ ++ + K S + ++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3017
Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
+ I + +D++ S + G ++ E D + L+ + +W L+ +
Sbjct: 3018 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3077
Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
+L + + + + + W+ +E + + + + + AS+++ + +HK
Sbjct: 3078 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3135
Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
++ ++ + + V+ QSL LS+ + + + +F++ W+ + +
Sbjct: 3136 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3188
Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
+ + L+Q L + E++++++N WL ++L L Q+ E + +
Sbjct: 3189 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3247
Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
+LL Q+++ L L+ LKQ+ V +++D I ++ + + T V +
Sbjct: 3248 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300
Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
L+ ++Q + +++L ++ + + + + V+ E + Q+ + L+ E
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3356
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
A++++ + L EV L L P A E +E+ ++R+ V+ I ++++ + +
Sbjct: 3357 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3416
Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
+ + A + + + E K L +I + QD Q VQKT
Sbjct: 3417 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3464
Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
L++ ++D L + S H ++ S + ++K L ++ + + +
Sbjct: 3465 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3518
Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
+LE + L+ E + L E S ++ + A + + E +L
Sbjct: 3519 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3577
Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
K + MN+ T L S +G + EK++ + Q+ E + +EA+
Sbjct: 3578 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3632
Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
K+D + SL ++E+ + + AEV I + I++ S + LQ L T
Sbjct: 3633 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 3692
Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
++ R E + S TD+ +A + + +D +V W++ T VE
Sbjct: 3693 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 3747
Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
+F D L+ +K + F S+ + + E +EI + +
Sbjct: 3748 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 3807
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
L G +L+ K V + I +L +W + + I + + ++ Q + ++
Sbjct: 3808 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 3865
Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
+ + + + P + DL K+ I+EL+Q + Q E++ + +A+L
Sbjct: 3866 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 3924
Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
+ E D +++ + L W+ L R+ R+ ++E L F EL AWL
Sbjct: 3925 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 3984
Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
E + + + + IE + ++ L ++ ++ + + G+ LI++S A+ +
Sbjct: 3985 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4044
Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
+KL +N RWQ++ + R ++L + + +L+ WL E L SKP+
Sbjct: 4045 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4103
Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
+ + EQ ++ ++ A E+ ++ C E + I Q
Sbjct: 4104 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4156
Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
+L +W ++ ER+ K+EE L +F + F +WL AE+T + ++
Sbjct: 4157 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4216
Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
+ ++ + F +++ Q+ ++K L ++ +K ++ RW+ +
Sbjct: 4217 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4276
Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
+R+ R L + ++F ++ WL E + L + +E ++ D ++ Q
Sbjct: 4277 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4336
Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
FQ+ + + D G L +K+ D L ++D L EL + G+
Sbjct: 4337 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4389
Score = 160 bits (404), Expect = 5e-38
Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)
Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
LT S LS G T+ L + A T G+ + + P+ SL+ KL +I++
Sbjct: 204 LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 261
Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
+L K S++ L E +I L + E++ Q + SDL + + S L++H
Sbjct: 262 LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 315
Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
KN + + +LKE + SE + + KL LE + +K+
Sbjct: 316 ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 365
Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
++ ++HL H +S + L + E + A + + + R +D H L +
Sbjct: 366 RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 421
Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
L +EE K ++E E+ L +A A + Q+ + QL ++++ +
Sbjct: 422 LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 481
Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
E EAT + + +++ + + ED Q + +++ + I
Sbjct: 482 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 541
Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
++++ L PL E I K E +L A+ + I
Sbjct: 542 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
+ P V K D++N Q+ N L L + SH + YL ++
Sbjct: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 659
Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
D +R + K G +H Q + ++ FL+ +Q D+T L KE+
Sbjct: 660 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
Y E K+ E+ L +++ + L++Q++ ++ D H
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
+ E + + + L T+ N +EF S + + +L + + N++
Sbjct: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
T L V +NT + + + K + E + + K +E + S
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 888
Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
LK RS EK+ F E Q + + ++ L+ DW K D VE +
Sbjct: 889 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948
Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ ++ + +S+K D +++ Q ++ Q E + L TQL +
Sbjct: 949 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008
Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
K + +E EC E + L + Y A +D+ ++ + ++ + S
Sbjct: 1009 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1067
Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
++++F + Y+ S+K L +++SL+ + V +++K++
Sbjct: 1068 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1127
Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
++I K K KI E +S + + L Q+ +HG + +++ +
Sbjct: 1128 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1186
Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
+ +QV E F+ + ++Q+++ S ++ +++ + R + +E+ +
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246
Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
T+ + H + + G +++K+ ++E+ KN E N LK+
Sbjct: 1247 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1303
Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
E L E L+L+AE K+ D + +KE + A L E
Sbjct: 1304 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1363
Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
I L D ++ + H ++ + ++ EE + L T
Sbjct: 1364 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1423
Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
+ T E+L QYQ + V+ +TQ +Q L LE++ + + K +
Sbjct: 1424 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1480
Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
L E + A +E ++K H + Q+EL++ D+ + L +EL
Sbjct: 1481 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1536
Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
E D + L + R + F ++ + HK R + + E A S + +
Sbjct: 1537 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1590
Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
+ ++ V+ ++ + DR ++ KC +L LK + D D S L LQ
Sbjct: 1591 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 1649
Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
K L E I K L EE Q +S + ++KK EV+L A S
Sbjct: 1650 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 1707
Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
+L + + K L D+I+ + + + EK + + + D L ++L
Sbjct: 1708 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 1758
Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
M +E S KE L+ QD + ++ + I + +N ++K D
Sbjct: 1759 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 1818
Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
A Q + S + A K +E ++ +++TK+ FE+L +L T ++ +T L
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 1877
Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
+ L++Y +E+ + +E LE + ++ G P + + L K
Sbjct: 1878 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 1936
Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
L ++D + EK ++S + +L L+ ++E K ++ +F A++
Sbjct: 1937 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 1996
Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
+ LE+ K K++E +++ V +S S + +A+ ++ A+++
Sbjct: 1997 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2051
Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
+T E + L ++ T E+ G+ L ++ L K L +A +E
Sbjct: 2052 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2111
Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
W +++ + +W+ + EA+ Q + E + +EL + L L
Sbjct: 2112 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2171
Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
+ + K Q L L + R + ++ + +TV A ++
Sbjct: 2172 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2231
Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
KE +L + + ++ T+ Q+ +E K ++Q T + Q + + + S +
Sbjct: 2232 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2291
Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
E+L ++ +K + + R + + + + +S + L D+D K+S+
Sbjct: 2292 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2349
Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
+ S+ AM +++E +++ +QQ+ K I+ AQ + + + + + K EL
Sbjct: 2350 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2404
Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
+++ I VEQ + + + Q+QQ+S+ + + + NK+ +
Sbjct: 2405 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2464
Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
K++ L+K E I +LL + L T+ +
Sbjct: 2465 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2524
Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
T ++ AL+ EQ L + +LE++ + E SI +
Sbjct: 2525 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2584
Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
L + + Q ++E L V I+ EV KS+ ++V + L SK+
Sbjct: 2585 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 2644
Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
+ ++ + EV E+ R ++ ++ L + QT K L +
Sbjct: 2645 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 2704
Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
+L QD+ + +E + QE + L + V ++ + + +++ +
Sbjct: 2705 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 2764
Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
N FS D+ D + + + E ++KQ I + ++ E L+
Sbjct: 2765 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 2824
Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
L E+ G++RD L A++ + + +R A R+ G++ L +++E S
Sbjct: 2825 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 2882
Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
+ +KAE +S + ME + TI Q+ +M ++
Sbjct: 2883 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 2917
Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
+ + QG + + + + +T +E D D + L +V + + E
Sbjct: 2918 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 2977
Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
L C V EL Q + E + + A +Q Q L Q+L+ +
Sbjct: 2978 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3037
Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
E+ K+A E K + L EAL K +T LE + ++ Q+ H
Sbjct: 3038 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3095
Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
E L+P+N L+ +E + Q ++Q+ + K +E D
Sbjct: 3096 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3138
Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
I + +H + + SS E+ D+ S L D Q +
Sbjct: 3139 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3179
Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
E+ K L + + + V + N+ L ++ + S L
Sbjct: 3180 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3225
Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
Q+ TE L K+ EL + L +V++ L + +G +V L
Sbjct: 3226 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3281
Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
E +K Y ++ D+ K + + L + L L+ + + + G
Sbjct: 3282 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3341
Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
+ +++ Q K L + K+ +L SLNE+S + +A E E VA
Sbjct: 3342 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3391
Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
++ ER L + Q+V +++ + +A ELS ++TE+++ + G + L
Sbjct: 3392 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3448
Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
+ QT +++ +Q +I HK LV + ++ A S + S+ +
Sbjct: 3449 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3497
Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
+ T +I E+ Q + Q WE ++E + L + + +IS LP+ +L
Sbjct: 3498 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3556
Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
ET + E ++Q++ I + + G QL+ EL G+ ++E++
Sbjct: 3557 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3607
Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
++ L +I ++ + L +S + D++ + LES + + + Q ++S ++
Sbjct: 3608 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 3666
Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
+ I+ I+ S ++++ L + G +++ + A Q + +
Sbjct: 3667 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 3720
Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
Q+ I E +H L E+ + E+ W +++ + +D+ + P S
Sbjct: 3721 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 3780
Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
VK + + R E+D Q +D V N ++ C K + + + E+N W
Sbjct: 3781 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 3836
Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
++ +I LE+ +++ + ++ +Q + +W++ +L ++ + + K
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 3892
Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
Q IE KS+A + + L A LL+ D EL S+
Sbjct: 3893 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 3950
Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
++ + ++ L + DE+ + KPV + + ++
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4010
Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
LQ++ + + + E + + L + A ++ K + ++RW V + + Q+
Sbjct: 4011 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4070
Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
L+ K + HGE L+Q + + LA+ + G E L ++ +
Sbjct: 4071 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4126
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
+ K + +L R P+ AE++ + +++L +R LE+ L
Sbjct: 4127 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4182
Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
+ A EF L F ++ + E + LD + Q E+ F N V + Q
Sbjct: 4183 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4240
Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
+++ HL S K + V +K L ++ +W + +ER L K +
Sbjct: 4241 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4298
Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
E W +L+E +EE+ K +++AN ++ Q +K + + ++ D+
Sbjct: 4299 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4356
Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
L + T + ++ + S+L D+W +R+ ++ + FT +++ L
Sbjct: 4357 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4416
Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
+L L+ E ++ L+ L + FQ+ +RT+ L+ + L+
Sbjct: 4417 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4471
Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
V ++ +L W+ + + +L ++Q F S V + + E
Sbjct: 4472 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4530
Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
R + ED L L + KE +K+LE+ A L + TM +
Sbjct: 4531 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4583
Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
+ + +K I + ++E++ +Q + L + E + L AWL E +
Sbjct: 4584 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 4643
Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
I + IE++ K + E F E ++ KQ + + K RAA+
Sbjct: 4644 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 4691
Score = 155 bits (393), Expect = 1e-36
Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)
Query: 616 ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
++L + E +L E VE + ++ S+ISK L+ K + SK ++
Sbjct: 1097 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1156
Query: 669 ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
+ L + K D N L K+ K E FS + +
Sbjct: 1157 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1216
Query: 714 QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
++K EK E + E+ +L+ D+ +LIG E + ++ + E
Sbjct: 1217 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1275
Query: 768 ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
E K + E++ +E+ L+ + + +S ++ ++ K+ EAK K +
Sbjct: 1276 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1329
Query: 828 VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
+K + K L V + + ++EES+ ++E+ + + E G +
Sbjct: 1330 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1386
Query: 880 KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
KHK+ + + T K+ +E+ N+ E D+ + ++ +++ + +
Sbjct: 1387 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1446
Query: 935 LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
+ Q + I + + +L+ + Q ++ E+K + K L +E +E +L
Sbjct: 1447 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1506
Query: 994 HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
H ++ EEL E + L+ EQ++E L A +I+ + S +E
Sbjct: 1507 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1560
Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
I T S NR + +K D A ++ L +
Sbjct: 1561 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1618
Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
++ L+++Y Y D L LQ + + S LQ +L + +
Sbjct: 1619 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 1678
Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
++ + ++ E + E + NDI+K D + R +L ++
Sbjct: 1679 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 1733
Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
N R E L+ L L V+ S L +PL+ A+Q D I
Sbjct: 1734 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 1786
Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
+++ QD +Q I N + E ++ P ++Q + +F +H+
Sbjct: 1787 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 1845
Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
V+ E+ + L+ FL + L + + VT+LS + E
Sbjct: 1846 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 1905
Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
K+ E L+K+ + H DK L + L FK+ E + TSC+ LDAF
Sbjct: 1906 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 1965
Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
+ + + +E T++ +++ F +L K+++D + K LK P + V +
Sbjct: 1966 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2022
Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
SL L + + ++ N+ + + ++ + + +
Sbjct: 2023 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2082
Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
E+ L+ + + + L L++ Q S + +QK + + + +
Sbjct: 2083 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2142
Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
+E K E + V+K+ ++ L L + E P K+ +D +W ++N+ T
Sbjct: 2143 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2202
Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
D + L + + ++ + +W EK L L L+ D L + Q +
Sbjct: 2203 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2261
Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
EF+ R + + L + + L + S+ ++ +T + + +L+G ++ + +
Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2319
Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
DQA + +SLL++LS S SL + T +EIQQ+
Sbjct: 2320 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2379
Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
Q K + L E+ + E +EL +Q E + F + ++H L
Sbjct: 2380 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2439
Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
++F W K + S +E ++ DF TL ++ ++ + +
Sbjct: 2440 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2499
Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
++ + L L + + + R +L++SL++ L+ ++ L W+
Sbjct: 2500 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2559
Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
N E+ K +P GE + ++L ++ +Q F V LNN+ KE
Sbjct: 2560 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2619
Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
E + +I + + ++ + ++ E+ +E K
Sbjct: 2620 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 2679
Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
+L T+ +S L H V K + + L+V E K
Sbjct: 2680 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 2728
Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
+LL+ E A+ + + Q + ++ L I + + + S + ++L
Sbjct: 2729 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 2788
Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
+ E + KE ++ L +L+ AL K+ + + DL + +
Sbjct: 2789 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 2841
Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
+L++ Q N LL+ + + E+ IK L E S L++ +Q + EH+ Q
Sbjct: 2842 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 2895
Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
V T++ F F + + E LQ Q+ N L L +S
Sbjct: 2896 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 2940
Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
++TS+ G + DD+ + + K + R A ++ + C L S+L TE
Sbjct: 2941 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3000
Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
+ L +K +++ V+ QE +++L +D E+ K ++A + +
Sbjct: 3001 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055
Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
+ + Q S+ ++ E +N E +N+ LE +++ NE L IEK
Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3115
Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
E LE+ +K ++ HN IG S + L + + K S
Sbjct: 3116 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3175
Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
Q + + QE + ++ L + + ++ + +L+++ ++ + + S L
Sbjct: 3176 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3234
Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
W+ S V D L + + Q L +G E ++Q IQ K Y +
Sbjct: 3235 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3291
Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
T L V T +Q L RL S E +++ + VLKG
Sbjct: 3292 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3344
Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
QA+++ K + E K K L D +N + W E L + AE+ ++ I
Sbjct: 3345 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3404
Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
K++E + W +L I L D +Q++ K
Sbjct: 3405 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3464
Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
IL + ++ L + + + + E + L+ + Y + +++R QLE
Sbjct: 3465 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3524
Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
+ F+ + + E+++ II ++ A E E TL Q+E +++ I+
Sbjct: 3525 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3577
Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
H + + + EL+ E ++++ ++I+ ++ ++ I Q
Sbjct: 3578 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 3637
Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
FH+K + E S++R L Q + + E+ +K++++ K + + KL+ +++
Sbjct: 3638 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 3692
Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
+ G + D S +LDQ+ T V E+E +L + ++ + F
Sbjct: 3693 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 3752
Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
+H + + DL+ + V+K + E+ R L + ++ L E
Sbjct: 3753 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 3812
Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
+I E D +K I ++ D L K ++ + +L QD L+
Sbjct: 3813 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 3866
Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
++ +L I +++ ++ + + EA+Q+Q+ E + +A ++K
Sbjct: 3867 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 3926
Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
EE S+ V+ L E + + L I R + L A L +++ A+ + +T
Sbjct: 3927 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 3984
Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
E ++ + VG +++E+ L K L++ V Q E + S+ E
Sbjct: 3985 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4043
Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
LQ L+ L + + E + ++ + + L K + ED+ L+ E L + +
Sbjct: 4044 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4103
Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
LP + +E L +E A + + K + K +Q+L RC ++ + + ++
Sbjct: 4104 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4159
Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
L EKW S+ E + EE W +E+ R ++ILD +
Sbjct: 4160 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4219
Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
++ E + + + E++ EL L Q + V + LL+++ + + +Q
Sbjct: 4220 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4279
Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
+ E +++ A+ ++ E K L ++ + + ++T++ + F
Sbjct: 4280 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4339
Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
K + A + + T + +++ + D+ + + EL Q+ L++
Sbjct: 4340 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4399
Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
L + L+ +Y + P E Q + L D + E+ K + S
Sbjct: 4400 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4459
Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
A++R E+ G + V+ +Q+ S E + L+ + E S V
Sbjct: 4460 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4519
Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
++E + G + D L Q+++ ++ E + ++LNKAT +
Sbjct: 4520 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4579
Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+ D + + + WI + + L H + AL K LL ++
Sbjct: 4580 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 4634
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
L+ TD+ + I + +V AL Q ME + + Q D V
Sbjct: 4635 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681
Score = 155 bits (392), Expect = 1e-36
Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)
Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
+L L+S+ ++L + ++ FS +++ Q Q+ +++ + +E Y +
Sbjct: 682 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 741
Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
++++ N + D+ + QI + L E R++ Q+ K++ L
Sbjct: 742 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 793
Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
KDD+ ++ +C++ + +S+ + LN +L++
Sbjct: 794 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841
Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
+ + + + V ++TQ + A+ KL E +++ + + + ++ + ++ DE+
Sbjct: 842 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 899
Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
+ +ELQ D M + + +++ + K+ A + +E+ + ++
Sbjct: 900 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 950
Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
+DN L+ L + K+ + +++ VE++ + + +E+
Sbjct: 951 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 996
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
T L++ K ++ IE ++ + + E S V D + + +++SQ K
Sbjct: 997 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1056
Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
+ I +++ Y TLM + D+ L+++++ L+ K
Sbjct: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1116
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
E+A +LQ S AE K + K+K + E+ ++ E L
Sbjct: 1117 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1166
Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
+ + L K + RN++++ + L S LL + L Q+++ + + D
Sbjct: 1167 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1218
Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
+ ++ V +E K+K+ LT E + + + + + K + ++L+
Sbjct: 1219 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1278
Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
++ + A + K + + QE + LI E EA++K + L+A Q
Sbjct: 1279 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1334
Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
+ +E+D ++T ++E T E++ QL+ K + + ++ N + E
Sbjct: 1335 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1384
Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
+Q E+ +E D N LL +V+ V NL + +K
Sbjct: 1385 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1444
Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
+++ + + Q Q E++++L++ +K+L E AL
Sbjct: 1445 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1499
Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
+ + L E+ D + L Q Q +E + D+I + KL K+F
Sbjct: 1500 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1557
Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
+ + + + D Y + N VLE + ++D +++ L
Sbjct: 1558 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1607
Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
H ++ +S + ++ +K + ++ + E + A + + +A TA + E + +
Sbjct: 1608 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 1666
Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
+++ +L E + LQ Q+++ + VL DA +L K + + ++ I
Sbjct: 1667 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 1722
Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
VG E+ + + E+L+ T+ +QD L E L + + E+ L+ Q
Sbjct: 1723 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773
Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
LQ+++SKN +++ +++ E K + + + ++L L
Sbjct: 1774 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 1833
Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
S ++E L ++E+ K V + E KL+ L TE D G + ++
Sbjct: 1834 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 1890
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
+ E LE K E+ LK+ S + + A++L+ NL ++ E+ T
Sbjct: 1891 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 1947
Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
KEA T+ CQ E ++ Q+L+ L I+ + VP
Sbjct: 1948 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 1986
Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
Q ++ K L+ +K +E + E I+L N TT + +A
Sbjct: 1987 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2045
Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
+ +E+F KG + + M + Y ++ ++ AE+ +++
Sbjct: 2046 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2100
Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
+ +KA E+ +K++ K + A E + + + + +N+ K
Sbjct: 2101 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2159
Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
QE++ K+ + L+ W L E+DS+ Q++ + D Q E N + FQ
Sbjct: 2160 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2219
Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
Q +Q E S Q + + ++E++ E
Sbjct: 2220 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2279
Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
+L+ P + SLR LS + A+ S Q +LL S+
Sbjct: 2280 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2339
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
L DL + + + NQ QK+ + + Q Q + +D+ A+ E
Sbjct: 2340 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2399
Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
+ +++ IL S + + E H++H + + ++ + ++ + Q
Sbjct: 2400 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2459
Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
P+ + +LE++ ++ + K + Q++ +++ I + +L
Sbjct: 2460 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2502
Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
L+ ++A +L ++ + KQ+ N+ KE L + K V L + +
Sbjct: 2503 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2562
Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
Q +E + +E E +A+ + ++++ N S+ + +++EV
Sbjct: 2563 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2622
Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
KS D E+ ++ + K+ +E S S +Q A ++ D+
Sbjct: 2623 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 2680
Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
+Q + L Q + SL+ + + + D +++SD++G + +VE E
Sbjct: 2681 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 2740
Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
+ + + + LE LQ N E + A+ + L++Q
Sbjct: 2741 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 2800
Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
+A L ++E +A +TCK ++ D + + EALS + L +
Sbjct: 2801 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 2860
Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
E+V+ L+E +S+ + +IL + +E EH+E+ PV + E E+I Q + K F
Sbjct: 2861 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 2915
Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
Q++++ L+ +Q +++ I+ AK Q +HD D T + A A
Sbjct: 2916 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 2975
Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
E D +S+LS W EL + K P L
Sbjct: 2976 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3027
Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
+L++ + ST + IL +++ + R+ + +T QLE +
Sbjct: 3028 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3087
Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
A E ++K+L +Q S +EE + + +D H
Sbjct: 3088 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3145
Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
L+ A+S G LK ++ E+ +++ D QV Q + RS+ L
Sbjct: 3146 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3193
Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
+ L + + + L + L + L + S+ + S + + +Q + ++ +
Sbjct: 3194 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3253
Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
V + G L L EV ++D L++ ++ARY +++ S V ++ + AL
Sbjct: 3254 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3308
Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
L E L K+ E L++ + K + A QAQ+ +N+K L
Sbjct: 3309 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3367
Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
V+ LL +++P W + K++ E + + + ++ QK EE D
Sbjct: 3368 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3412
Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
A++ + + + +S + ETE++L+ ++ S Q+++ + R
Sbjct: 3413 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3469
Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
+++ G +++ + S E + KL+ + +N + +L R Q+L+
Sbjct: 3470 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3529
Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
+ ++L WL +Q ++ +L + +T+R + + + E
Sbjct: 3530 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3582
Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
+ G QLL L + +++ + ++ + + L + + I
Sbjct: 3583 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 3642
Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
+++ + + + S+ + ++K + ++K ++M+ Q + + + Q ++
Sbjct: 3643 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700
Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
+ D+ +K + + L +M W +H ++ + L ++E +
Sbjct: 3701 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 3755
Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
L ++ ++ ++ L+ P SV K Q+ + + L E + L S
Sbjct: 3756 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 3812
Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
+ + IDEL S+ ++++L+ +MQ+ +Q ++D V+
Sbjct: 3813 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 3872
Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
+ + + P+ LET++ Q+E L+ + EA + E+L L K
Sbjct: 3873 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 3928
Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
S +++ W + + I ++ K + L + +A E A L E
Sbjct: 3929 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 3988
Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
+ + G+ A + A + LQ+DV Q T EA + + L E+S
Sbjct: 3989 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4043
Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
L L L QR + + + + + L Q K F +E L+ + E +L
Sbjct: 4044 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4101
Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
L + KE + + A A+ + L ++ + P S + + N+
Sbjct: 4102 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4161
Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
+W ER ++L+ + L +F + +I L + E+ L V S P L+
Sbjct: 4162 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4218
Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
+++ E +V N+ +S+ Q ++L T T ++ ++ + + L RW+
Sbjct: 4219 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4276
Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
VQ + +R +D ++ + F + L +L ++ L S ++ +T+ H+
Sbjct: 4277 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4336
Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
K + + + T G L T L + +S+L+D W + + E
Sbjct: 4337 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394
Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
+ + + Q ++ L L ++ Q + P +H D+ LI K ++ L
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4453
Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
T +++ L+ +L +D +K Q++ L +WE +C ++ +E L
Sbjct: 4454 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4512
Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
F+ L WL + E VL + ++ +I++ K+ M+++ +
Sbjct: 4513 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4571
Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
MGD ++ + I + I R++ + ++L A + + + L
Sbjct: 4572 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4631
Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
WL E+ L+ K V+ + +E++ +AE Q ++ + V+ V
Sbjct: 4632 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 4689
Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
D + ++T+ ++ L +W+ + +++E
Sbjct: 4690 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 4749
Query: 6127 RRMKIEE 6133
RR K+ +
Sbjct: 4750 RRRKLND 4756
Score = 146 bits (369), Expect = 6e-34
Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)
Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
P+ +AM P++ F++ P +E++ +E+ Y + E + + ++ H+L
Sbjct: 601 PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 656
Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
N RI S+ +S + Q L++LQ + +E ++ S +LE VN
Sbjct: 657 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 716
Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
K+ + ++ LK ERE Q + R+E+ E L ++ P+E+
Sbjct: 717 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 772
Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
L H+ F + + +++ + L ++D + I N+ EE +
Sbjct: 773 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 817
Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
L + N++L+ Q M+ D LK + L + + A+ + T L +
Sbjct: 818 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
+A +N + T+K E+ H ++D KAK + K K D+ F
Sbjct: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
+ D E N+ +L + G G ++ + L+ I + + IQ+ Q
Sbjct: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
+ SK T+ +++K L+ ++ + +E +++ ++ + ++ KD +T+
Sbjct: 995 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1045
Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
+ ++ K+ V Q L +++++ + ++ T L+ + Q
Sbjct: 1046 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1095
Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
++LK+ E + ++EE EH+E ++ + N+ L + +PPF K+
Sbjct: 1096 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1149
Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
+E+ E L AL I + K KM T+E+R L++++
Sbjct: 1150 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1192
Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
+ + E FS + ++Q S ++ +E +++ I + + + L
Sbjct: 1193 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1252
Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
G + T EL+ + + K G ++L + + +++ E KL + +
Sbjct: 1253 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1312
Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
+++QK L E +I C L + + KK+ + V +++ +L + K
Sbjct: 1313 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1368
Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
N DW SN+ + + F+ + K ++ ++ + + L
Sbjct: 1369 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1428
Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
T E N + ++V + ++ + + +++ GQ E+ E + Q KE
Sbjct: 1429 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1487
Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
L+ SLQ+ L D D+ WL E++ + +E +
Sbjct: 1488 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1547
Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
L R++ E V L+ + + +C
Sbjct: 1548 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1607
Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
DR+++L + + + K L + Q + D +A D
Sbjct: 1608 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 1667
Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
+ ++++E+ + + E+++K E++L DAR + + + +Q
Sbjct: 1668 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 1716
Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
KTL DI ++++ L+ + EKL + + L ++ L ML +E K++
Sbjct: 1717 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773
Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
L A I K + QD+ +S N + E K + +P
Sbjct: 1774 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 1819
Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
SL +++D +H + +L T + +N S++ +F + +
Sbjct: 1820 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 1879
Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
V E Q +QE + L+ + +L K + + + ++ + +L
Sbjct: 1880 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 1939
Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
K K++E+ + K+ + C ++KS +S K+ +P + D+ +S
Sbjct: 1940 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 1999
Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
+++ +KL+E W EI K A+ S LN + +
Sbjct: 2000 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2056
Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
NTE+ ++ + ++ + +L +L+++ E KL +A++ + ++
Sbjct: 2057 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2116
Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
+ +NKT T + +A+ T +++NK + E+ +
Sbjct: 2117 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2153
Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
K + + LK D +T L + + K L + KW+ L+ D +KL
Sbjct: 2154 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2209
Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
ES + Q ++ + Q +VE + +++ + L Q+Q +Q+ L+
Sbjct: 2210 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2263
Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
R Q T G +L E + +++ + + ++W++L
Sbjct: 2264 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2308
Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
+ + I + +++ +++L + +L +L+ S+ + PD + Q+ +
Sbjct: 2309 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2368
Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
I ++ + ++L E++ V Y ++L+ LE + ++ + K+
Sbjct: 2369 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2426
Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
Q L+ F + R FQ + + E + K H ++ LE+
Sbjct: 2427 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2474
Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
K+ ++ ++ +H+ E T N+ + E+ L+ QL +K + + ++
Sbjct: 2475 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2534
Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
N+++ ++ ++ E+ L D Q N E+ + +G ++
Sbjct: 2535 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2594
Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
+ + + L +L V ++ K ++D + Q+ K+ LE ++
Sbjct: 2595 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 2654
Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
F+E + K Q +K +D+ ++ + ++++ + Q L +++ AK L
Sbjct: 2655 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 2713
Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
+++ + +++K D +LQ++ A+E+ L + + L K + Q+ +
Sbjct: 2714 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 2768
Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
+ +L + + + +Q +K+ +AF +++ A M S K
Sbjct: 2769 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 2828
Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
+ D+ R+ E L Q N +D L + Y L + + +A
Sbjct: 2829 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 2888
Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
E S P ++ + L M + ++EE+E QD+ G+I S
Sbjct: 2889 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 2944
Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
Q +L N+ K K A + E + ++ + + LS M E V
Sbjct: 2945 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3004
Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
Q S ++ ++++ K L L K + +++ + D + +LK
Sbjct: 3005 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3062
Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
+S L +W +LL A+ E + + E +E L +++ L E T+
Sbjct: 3063 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3122
Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
+ E++++ L D + + +++ + + + + + + E V++ F ++
Sbjct: 3123 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3177
Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
+ ++ +K EL+Q + F ++ + L N+ + ++ QD+ +
Sbjct: 3178 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3232
Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
+Q EL+ + + L +N+ + L + E I+ ++E + +DI
Sbjct: 3233 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3291
Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
K+S +V K+ + + R++ EE+ L VE L K + +AQ K
Sbjct: 3292 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3351
Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
++ E + L+ L+ ++E P +A+E ++ ++ ++Y+ VS + ++
Sbjct: 3352 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3411
Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
+ A ++ +++ + +WI T L + D L ++ Q+ ++ + L
Sbjct: 3412 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3467
Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
H + D+L +S ++ + + Q + + L ++ + D + I SE
Sbjct: 3468 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3516
Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
+ + +S++ L E EEH + E+I
Sbjct: 3517 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3576
Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
E +I M KT +++ P G + + L IK E+V +++ L
Sbjct: 3577 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3628
Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
I Q+ ++ ++I+ + + SLE + ++ + P + E+E++++QI
Sbjct: 3629 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 3674
Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
+++ VD++ + L++ LKQ E
Sbjct: 3675 ENKNVSVDME-KLQPLYETLKQRGE 3698
Score = 90.9 bits (224), Expect = 4e-17
Identities = 379/2122 (17%), Positives = 783/2122 (36%), Gaps = 342/2122 (16%)
Query: 4938 RLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQ-----DLDTIRSNINNFF 4992
R L LL N +++ ++ Q LN+ E + + + DL ++ S++ N
Sbjct: 259 RKPLLKSSLLDQNLTEEEIN--MKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHK 316
Query: 4993 EFSKEVDE-KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
+ ++E +SSLK A IS LK T L + E ++ L+ + + L
Sbjct: 317 NVHRAIEEFESSLKEAKISEIQMTAPLK----LTYAEKLHRLESQYAKLLNTSRNQERHL 372
Query: 5052 HQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYK 5111
L SR A E+I W+N E + D ++ ++ K H E E+D K
Sbjct: 373 DTLH--NFVSR-ATNELI-WLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQK 425
Query: 5112 QWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQ---L 5168
+ + V + QL + R + M QW + + QH+++
Sbjct: 426 EENIKSVQEIAEQL----LLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 481
Query: 5169 LESITESENKIQILNNWLEAQE-----ERLKTLQKPESVISV----QKLLLDCQDIENQL 5219
E +++ L N +A + +R ++ K E ++ ++ LL + L
Sbjct: 482 FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 541
Query: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEW 5279
K+K + +LK + PL + +++ + + ++ + S +W
Sbjct: 542 MGKAKTIIQLKP-----RNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKW 596
Query: 5280 KIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAE---SSEGSWEK 5336
K+ +E + ++ F + + V L+ + Q +N+ +L E+ S SW
Sbjct: 597 KVISPTGNEAMVPSVCFTVPPPNKEAVDLA-NRIEQQYQNVLTLWHESHINMKSVVSWHY 655
Query: 5337 LQEVIGKL--------KGLCPSVAEIIEEKCQNTHKRWTQVNQAI----ADQLQKAQSLL 5384
L I ++ K + P + + Q+ + + + +Q + + + +
Sbjct: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 5385 QLWKAYSNAHGEAAARLKQQEAKFQ----QLANISMSGNN-----LAEILPPALQD---- 5431
+ K Y ++A R +Q+E+ + ++ NI + N + +I P +D
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
Query: 5432 --------------IKELQHDV----QKTKEAFLQNSS-------------VLDRLPQP- 5459
++ L+ D+ K +E F Q ++ VL + Q
Sbjct: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
Query: 5460 AESSTHM----LLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMH 5515
+ SST++ + L + Q A L K+ K E E V++ + + +LK
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
Query: 5516 EEENLDRLHQQEKE-NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQ 5574
+E H E E ++ + T + D++ D + + +
Sbjct: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF-----------DWHKEKADQLVER 944
Query: 5575 WIRATATALERCSELQGIGLNEKFL----YCCEKWIQLLEKIEEALKVDVANSLPELLEQ 5630
W R +L+GIG + K+ + + WIQ +E + ++ + + L Q
Sbjct: 945 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1004
Query: 5631 QKTYKMLEAEVSINQTIADS---YVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQG 5687
KML +E+ + Q+ D Y Q + E++ + + D Q +
Sbjct: 1005 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT-----YRAMVDSQQKSPVK 1059
Query: 5688 VRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL--SAVKGQERFSLYQTRSLIHELK 5745
R+ + D +++++ D T L +T S + +E + H K
Sbjct: 1060 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1119
Query: 5746 NKEIHFQRRRTTCALTLEAGEKL---------LLTTDLKTK-ESVGRRISQLQ------- 5788
KE+ Q+ + + TL+ EK + + ++ TK E + + +Q
Sbjct: 1120 AKEL--QKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG 1177
Query: 5789 -----DSWKDMEPQL-----------AEMIKQFQSTVETWD-QCEKKI-----KELKSRL 5826
+ ++E Q+ +E +KQ Q + + D + E+KI +E K +L
Sbjct: 1178 DKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKL 1237
Query: 5827 QV---LKAQSEDPL-------------PELHEDLHNEKELIKELEQSLASWTQNLKELQT 5870
Q L Q+E+ L EL + ++EL K+++ S + + +K +
Sbjct: 1238 QGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN 1297
Query: 5871 MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNK--- 5927
+ + ED ++++++ + E L L+ K+E+ D++ T + E K
Sbjct: 1298 FLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL-DKVVTTAIKEETEKVAA 1356
Query: 5928 ------------ELCAWLVQMENKVLQTADISIEEMIEK--------------------- 5954
L WL ++ K + A +++IE+
Sbjct: 1357 VKQLEESKTKIENLLDWLSNVD-KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVN 1415
Query: 5955 ---LQKDCMEEINLFSENKLQ---------------------LKQMGDQLIKASNKSRAA 5990
L+ D ++ EN Q Q L++ + +
Sbjct: 1416 GNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1475
Query: 5991 EIDDKLNK-INDRWQHLFDVIGSRVKKLKETFAFIQQLDK---NMSNLRTWLARIESELS 6046
E +KL K + + H + KK+K T + ++L+K + + WL + E EL
Sbjct: 1476 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1535
Query: 6047 KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANET--ECD 6104
+ D + +L Q+ D+ H + + + +L + +C+ + D
Sbjct: 1536 N-LEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1594
Query: 6105 SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED-------WLKSAER 6157
+ T R + R+ + K + +D Y +ED L++ E
Sbjct: 1595 T-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA 1653
Query: 6158 TAACPNSSEVLYT--SAKEELKRFEAFQRQIHERLTQLELINKQYRRL--ARENRTDTAS 6213
TA+ S + + + +L+ +A Q QI + +E + K L AR + +
Sbjct: 1654 TASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 1713
Query: 6214 RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWL--TEMDLQLTNV 6271
+++ + + R+++L + V +L+ + + + +L W+ E L+
Sbjct: 1714 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773
Query: 6272 EHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEEL-- 6329
+ + D + + +Q+I + I+ + ++ ++ ++P A ++ ++++L
Sbjct: 1774 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 1833
Query: 6330 ------HRY------CQEVFGRVSRFHRRLTSCTPGLEDEKEA-SENETDMEDPREIQTD 6376
H++ +E+ +V F LE + +A +E + +D E+
Sbjct: 1834 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 1893
Query: 6377 SWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEE 6436
E E + H + G + + L + T ++ ED
Sbjct: 1894 MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-----LVLEKTNNLSKKFKEMEDTI 1948
Query: 6437 GPYYSALSDVE--------IPENPEAYLKMTTKTLKASS--------GKSISDGHSWHVP 6480
A++ + + ++ ++++K TTK + GKS+ D
Sbjct: 1949 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2008
Query: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNG----- 6535
S PE G ++ + A +TP K K G VLNG
Sbjct: 2009 WSLKTPEIQKVNNSGI-SLCNLISAVTTPAK----------AIAAVKSGGAVLNGEGTAT 2057
Query: 6536 NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIKQNLQQLNSDISAIT 6587
N ++ + GL I + + +E + + EL+ KL LQ+ + SA+
Sbjct: 2058 NTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS---KLQKAQEESSAMM 2114
Query: 6588 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQ-- 6645
WL+K + P+D + ++ +V++ + V + E L+
Sbjct: 2115 QWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN 2174
Query: 6646 TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
++PE+ + L ++ W+ + L +S F + L WL
Sbjct: 2175 PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLV---E 2231
Query: 6706 RRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIE 6764
+ V P DP L R+++ L +E R+PQ + L +L + + +
Sbjct: 2232 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2291
Query: 6765 --AEEKVHVIEKKLKQLREQVS 6784
+E++ + +K L Q+S
Sbjct: 2292 GIVKEQLAAVTQKWDSLTGQLS 2313
Score = 88.6 bits (218), Expect = 2e-16
Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)
Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
++LS G+ +QE++ + L L+ I ++ + I + + +I
Sbjct: 3593 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3652
Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
+ P++ A + K + ++K+ YE K+ +EM A S KD
Sbjct: 3653 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 3712
Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
K V + V +WEN LV E + V+EL +++ + S++ T+ ++ + L
Sbjct: 3713 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 3772
Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
+ + +K++ E ++EE + E +D + + L + ++P +K
Sbjct: 3773 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 3829
Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
+ + W +N+ +D + L A+ + + + +W + A K+ D E
Sbjct: 3830 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 3889
Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
+K++++ +Q SE ++ E++ L +E+ L+ ES L +++ + L
Sbjct: 3890 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 3949
Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
+ H L G + + + LD+ + TE LL P ++E +
Sbjct: 3950 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4009
Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
+LQ K L+E+ G L +L L +++++V + +K L
Sbjct: 4010 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4069
Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
+K + + ++ W ++ + +L K ET K EQ + E +
Sbjct: 4070 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4127
Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
K + + + PK+ + + + + E +E+ R +LE++L +
Sbjct: 4128 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4187
Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
+ ++ WLT E+ P ++ ++F + REQ + +
Sbjct: 4188 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4247
Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
LK F++++++++ L+ R++ ++++L E + F++ ++
Sbjct: 4248 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4305
Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
W++E ++SL + ++ + KIK + E + ++ + L
Sbjct: 4306 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359
Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
+KT L+++ ++WD + + E+ LL ++ + + L L
Sbjct: 4360 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4419
Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
++ + + + + +K F K+ TS ++ LK L+E ++ + S+
Sbjct: 4420 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4479
Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
+ E+ E++ L+ +R+ + + V L L +
Sbjct: 4480 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4539
Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
P D+ A+ + + +E +L + L K +LA+ T II+
Sbjct: 4540 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4599
Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
+ + K + RLAS AKQE +E L + ++ + K K +P ++ +
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4659
Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
+ +E T++ V+K+ + ++
Sbjct: 4660 LIAEHQTFMEEMTRKQPDVDKVTKTYK 4686
Score = 58.2 bits (139), Expect = 3e-07
Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)
Query: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4381 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4438
Query: 6613 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6672
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4439 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4498
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6731
S + L +L Q ++FH + LL WLA A+ R + D + R L++ +E M
Sbjct: 4499 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4557
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6779
K+L E++ +++ + +++L H + + + +I + +++
Sbjct: 4558 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4603
Score = 53.5 bits (127), Expect = 7e-06
Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)
Query: 6571 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6627
K+++ +Q Q + A+ W+ +L M+ +D++ ++ +++ L++
Sbjct: 3849 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 3906
Query: 6628 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6685
+ + +N ++ L+ TE + +Q L +L L+W++ + + + + L +L+
Sbjct: 3907 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 3966
Query: 6686 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6743
F LL WL + QK DPKA L + L+ +++ Q V
Sbjct: 3967 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4022
Query: 6744 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6797
+ + + N L+ GE+ + K+ V+ ++ + + E+ Q L G A
Sbjct: 4023 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4076
Score = 45.4 bits (106), Expect = 0.002
Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)
Query: 585 LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
L W T+ E L + + K EI+ L L H + +N+AGN L+E S
Sbjct: 3977 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4036
Query: 640 NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
S++ +L LN+RW+ ++ KT+ +KQ L +
Sbjct: 4037 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4078
Query: 700 FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
F ++ E+ Q + E+H ++ G + AK E+L +E+ A EAK
Sbjct: 4079 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4127
Query: 759 QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
EE+ K L+ KG M +E + DI N+ +E ++ V + K+
Sbjct: 4128 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4172
Query: 818 EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
E K K++ L++ ++ S ++ +++ +A+Q L P +
Sbjct: 4173 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4215
Query: 878 -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
I +HK + S+ + + + K LK + + ++ V ++WE
Sbjct: 4216 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4275
Query: 929 LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
+ VQ+L +E+G+ D+ K KQ ++ KL+ K L E E
Sbjct: 4276 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4325
Query: 986 EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
+ QL H E + L + + R LK+
Sbjct: 4326 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4361
Score = 43.9 bits (102), Expect = 0.006
Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)
Query: 6564 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6623
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2427 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2481
Query: 6624 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6681
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2482 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2540
Query: 6682 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6741
SL + + + + L W+ +N ++ DP +L L+KE+ +
Sbjct: 2541 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2597
Query: 6742 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6801
V++L +NSLL + + +E +I+ K+ + EQ+ L +N
Sbjct: 2598 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 2653
Query: 6802 SFDEV 6806
F EV
Sbjct: 2654 EFQEV 2658
Score = 41.6 bits (96), Expect = 0.028
Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
W+ ++ + ++ + K++ L Q + + WL TE +L KP D + IE
Sbjct: 3946 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4002
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
+ + + + +++ V +VN + + +++ + E++ LQ++L L+ W+
Sbjct: 4003 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4062
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ + L +L Q + FH ++L WL + H+ K L E +E + +
Sbjct: 4063 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4116
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6778
E+ + +E SL+ KG +D +EK +E KL +
Sbjct: 4117 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4173
Query: 6779 LREQVSQDL 6787
+ ++ + L
Sbjct: 4174 RKTKLEEAL 4182
Score = 40.0 bits (92), Expect = 0.080
Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 8/153 (5%)
Query: 6557 RWEMIQAQELHNKLKIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 6613
RW+ + + K ++ L+Q + +I + WL TE L K + + +
Sbjct: 4054 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4113
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGA 6671
L V E+ AF+ + S+ ++ L P+S E + + L WE+ +
Sbjct: 4114 LNVH--MEVCAAFEAKEETYKSLMQKGQQML-ARCPKSAETNIDQDINNLKEKWESVETK 4170
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6704
++ + L ++L +FH Q+ + WL A+
Sbjct: 4171 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4203
Score = 38.9 bits (89), Expect = 0.18
Identities = 45/216 (20%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 6577 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6634
QQ + A +W+ +TE +L L + D +L+V++ EIL+ D LV
Sbjct: 3419 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3478
Query: 6635 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6694
S K E ++ +L ++ ++ L ++ F + +
Sbjct: 3479 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3535
Query: 6695 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6754
L WL ++ + + P + L + + E QL + + E +P +D + + LL
Sbjct: 3536 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3593
Query: 6755 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL 6790
GE +EK + Q++E V + +AL
Sbjct: 3594 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVAL 3628
Score = 37.0 bits (84), Expect = 0.68
Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)
Query: 6558 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6610
W + ++ H++ ++ Q N + D + WL + +L L + ++ Q
Sbjct: 3178 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3237
Query: 6611 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6670
+ ELRV + +L+ + +AL+ + + QT E +Q +L + ++
Sbjct: 3238 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3293
Query: 6671 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6730
L Q+L + H + L WL + K + + + R +
Sbjct: 3294 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3351
Query: 6731 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6783
+L+KE + +D L E+S++LL +G + E E+ ++ + Q E++
Sbjct: 3352 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3411
Query: 6784 SQDLMALQ 6791
++ Q
Sbjct: 3412 DAAILRSQ 3419
Score = 36.2 bits (82), Expect = 1.2
Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)
Query: 310 KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
K+++++L K +++ Y ++ ME N + + L ++ + D + ++L+
Sbjct: 3892 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 3945
Query: 370 WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
WD L+ +I + KL AL L + AWL E L+ E D +A+ +
Sbjct: 3946 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4004
Query: 423 ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
+Q + +S ++ N L+ +E ++L NKLE + +R N+LE
Sbjct: 4005 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4060
Query: 476 K 476
K
Sbjct: 4061 K 4061
Score = 33.5 bits (75), Expect = 7.5
Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)
Query: 6647 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6706
+S + L+ L ++ W+ V L+++L+ C F ++LL W+ +
Sbjct: 2943 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3000
Query: 6707 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6766
A+ P A+ + + +E L++ L +R+ V++++ + D ++
Sbjct: 3001 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3060
Query: 6767 EKVHVIEKKLKQLREQVSQDLMALQG 6792
+++ +++ + + L + L+G
Sbjct: 3061 KQLSLLDSRWEALLNKAETRNRQLEG 3086
>gi|19923599 calmin [Homo sapiens]
Length = 1002
Score = 224 bits (570), Expect = 3e-57
Identities = 128/272 (47%), Positives = 173/272 (63%), Gaps = 7/272 (2%)
Query: 18 IDDLHI-SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSG 76
I D+ + +LQ E+E+ QK+ FT WIN L + P + DLF DI+ G +L+ LLEVLSG
Sbjct: 18 ISDIRVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSG 77
Query: 77 QQLPRDKGSNTFQC-RIN-IEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILH 134
+ L + S++ + R+N I AL FL + ++KL++I +I DGNPS++LGLIW IIL
Sbjct: 78 RNLLHEYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILF 137
Query: 135 FHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPP---AKKCSKVQARWQMSARKALLLWA 191
F I++L LS N SL S S +S PP A++ + + Q A KALL W
Sbjct: 138 FQIKELTGNLSRNSPSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWV 197
Query: 192 QEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQ 251
Q + Y V V DF SWR+G+AFLA+I A+ P L+DMK S ++NL +AF IA+
Sbjct: 198 QRKTRKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQD 256
Query: 252 ELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQ 283
L IPRLLEPED+ V PDE+SIMTYVAQFL+
Sbjct: 257 ALHIPRLLEPEDIMVDTPDEQSIMTYVAQFLE 288
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 223 bits (568), Expect = 5e-57
Identities = 586/3068 (19%), Positives = 1192/3068 (38%), Gaps = 510/3068 (16%)
Query: 1 MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
MA E + G D+ S E D QKK FT WIN++ ++ P I+D+FTD
Sbjct: 1 MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPP-INDMFTD 59
Query: 61 IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
+K G LLDLLE L+G LP+++GS N+ L L +++L+NI TDI+DGN
Sbjct: 60 LKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGN 119
Query: 121 PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
+ LGL+W+IILH+ ++ + + + + Q
Sbjct: 120 HKLTLGLLWSIILHWQVKDVMKDVMSDLQ------------------------------Q 149
Query: 181 MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
++ K LL W ++ Y VNV +F +SW +G+AF A++H +PDL V S +
Sbjct: 150 TNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIE 209
Query: 241 NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQ----------------- 283
L AF A+ L I +LL+PEDV V PD+KSI+ Y+ +
Sbjct: 210 RLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETL 269
Query: 284 ---YSK-----------------------DAPGTGEEA-------QGKVKDAMGWLTLQK 310
Y K + P T E Q +++ + WL +
Sbjct: 270 PRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAE 329
Query: 311 EKLQKLLKDSENDTYFK-KYNSLLSFMESFNEEKKSFLDVLSIKRDL-----------DE 358
+ Q+ S++ K ++ + +FM + S VL L E
Sbjct: 330 DTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFE 389
Query: 359 LDKDHLQLREAWDGLDHQINAWKIKLNYAL----PPPLHQTEAWLQEVEEL--------M 406
+ + L W+ L + + +L+ L L Q AWL EE +
Sbjct: 390 IQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPL 449
Query: 407 DEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEM 466
D+D+ + Q + +Q + + ++ H +++ EN E+ ++ ++L+++
Sbjct: 450 DDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH--MVVIVDENSGESATAIL-EDQLQKL 506
Query: 467 KRRIN----------NILEKKFILLLEFHYYKCLV---LGLVDEVKSKLDIWNIKYGSRE 513
R N L++ IL E +CL+ L +E +K+ N K
Sbjct: 507 GERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKEL 566
Query: 514 SVE-----LLLEDWHKFIEEKEFLARLDTSFQKCGEIYKN-LAGECQNINKQYMMVKSDV 567
SV +L ED +++ L +L Q G++ N A + N + + + + D
Sbjct: 567 SVSVRRLAILKEDMEM---KRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDS 623
Query: 568 CMYR-----KNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWN 622
+ R + + L +E +R+ + K+E+ P Q +
Sbjct: 624 LVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIH 683
Query: 623 LEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQ-- 680
++ + E+ N ++ + + + K + K+ ++++ L + K+Q +
Sbjct: 684 VDIEAKKKFDAISAELLNWILKWKTAIQTTEI-KEYMKMQDTSEMKKKLKALEKEQRERI 742
Query: 681 ---PTFDNSGNIL----SKEEKATVEFSTDMSVELPE--NYNQNIKAGEKHEKENEEFTG 731
+ +G IL KE T E + E N +Q+++ E+ + E+
Sbjct: 743 PRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINA 802
Query: 732 QLKVAKDVEKLIGQVEIW-------EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELM 784
K ++EK+I E W E+ +S+ D S + L +L+ +
Sbjct: 803 YFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKD---SCQRELTNLLGLHPKIEMAR 859
Query: 785 ARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVK---------LIAALK 835
A ++ Q F L G +QEA E Q ++ + LK
Sbjct: 860 ASCSALMSQPSAPDFVQRGFDSFL--GRYQAVQEAVEDRQQHLENELKGQPGHAYLETLK 917
Query: 836 NLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAK 895
L DV D + + ++ + + + + ++ L ++++ E++ K AL LA+
Sbjct: 918 TLKDVLNDSENKAQV---SLNVLNDLAKVEKALQEKKTLDEILENQKPAL-----HKLAE 969
Query: 896 YLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQL-KIDIEKGKLSDNIL 954
KA+E+ NV D++ +++ DV KW L +S + L +I + +
Sbjct: 970 ETKALEK---NVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADST 1026
Query: 955 KLEKQINKEKKLIRR-----GRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEEL--- 1006
+EK ++ K + + G GL ++ + C + + + ++ ++E+ L
Sbjct: 1027 VIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSG 1086
Query: 1007 PSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHS 1066
P + V+ L DY+ ++E+L K I T ++R +
Sbjct: 1087 PVAGIKTWVQTRLGDYQTQLEKLSK---------------------EIATQKSRLSESQE 1125
Query: 1067 EAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYS----ASINSLLERYDTY 1122
+A K D E + EE +E+D+ + S +E
Sbjct: 1126 KAANLKKDLAEMQEWMTQ--------------AEEEYLERDFEYKSPEELESAVEEMKRA 1171
Query: 1123 R-DILEHH-----LQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEF-EI 1175
+ D+L+ L++N + + S +S L L + Q++ N + E+
Sbjct: 1172 KEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEV 1231
Query: 1176 ISLKLE-NHVNDIKKPFVIKERDTLKERERELQM------TLNTRMESLETALRLVLPVE 1228
S +E H D++ ++ +TL+ER + ++ +N +ESLE+ LR P +
Sbjct: 1232 WSCWIELLHYLDLETTWL----NTLEERMKSTEVLPEKTDAVNEALESLESVLR--HPAD 1285
Query: 1229 KASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICN-RLEEPGNFVLK 1287
+ ++ G LID + D I++++E N R E+ + L
Sbjct: 1286 NRT-----------QIRELGQTLIDGG-------ILDDIISEKLEAFNSRYEDLSH--LA 1325
Query: 1288 ELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSA 1347
E L ++ + + +Q +++L L+ L + T ++ A
Sbjct: 1326 ESKQISLEKQLQVLRE-------TDQMLQVLQESLGELDKQLTTYLTDRIDA-------- 1370
Query: 1348 SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFS 1407
QV QE + + EI + + L + ++ ++ ++ S +D
Sbjct: 1371 --FQVPQE----AQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGS---QMDVLQ 1421
Query: 1408 IKLSE--THGYGVQEEFTEENKLLEACIFKNNELLKNIQD-VQSQISKIGLKDPTVPAVK 1464
KL E T Q+ E ++L+ K + D V++++ + +KD ++
Sbjct: 1422 RKLREVSTKFQLFQKPANFEQRMLDC---------KRVLDGVKAELHVLDVKDVDPDVIQ 1472
Query: 1465 HRKKSLIRLDKVLDEYE-EEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523
++L K L E + E + ++ + + + K +++Q + VL+ + A V
Sbjct: 1473 THLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQV 1532
Query: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG-KENLKKRIAEIEIVKE 1582
TE + R +L ++ + + L+ + E+ + +++ G +L I+ + V +
Sbjct: 1533 TEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLK 1592
Query: 1583 EFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG 1642
+ + ++ I + LQ + EP E+ ++ W + TED+ L
Sbjct: 1593 DLEKRKADLNTITESSAALQNLIEG----SEPILEERLCVLNAGWSRVRTWTEDWCNTL- 1647
Query: 1643 RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE 1702
H+ + F VA
Sbjct: 1648 --------------------------------------------MNHQNQLEIFDGNVAH 1663
Query: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG 1762
I L +E L+ +E +K E + K L E L + ++ DQA +
Sbjct: 1664 ISTWLYQAEALLD--EIEKKPTSKQEEIVKRLVSE-----LDDANLQVENVRDQALILMN 1716
Query: 1763 MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCL-TPELSELKKQYESV 1821
S + L E+ E++ Q I K +I E CL T E E + +
Sbjct: 1717 ARGSSSRELVEPKLAELNRNFEKVSQHIKSAK-LLIAQEPLYQCLVTTETFETGVPFSDL 1775
Query: 1822 SDLFNTKKSVL---QDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878
L N +++L + H +D+ + ++ + I+ L+ E +K +
Sbjct: 1776 EKLENDIENMLKFVEKHLES--SDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIR 1833
Query: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF--ELEKMESICQARAK 1936
L L R +KIK + +++ + S L+ ++ E+ K+ +C
Sbjct: 1834 LQLLLLHTRYNKIKAIP-----IQQRKMGQLASGIRSSLLPTDYLVEINKI-LLCM---- 1883
Query: 1937 ELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQL 1996
D ++ L + + + + + + QE+ K +++ +K + K+
Sbjct: 1884 ---DDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQP-------- 1932
Query: 1997 NNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHW 2056
+ + E E +I T L ++ + R S+ + E + F+ +D+ W
Sbjct: 1933 -DVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQW 1991
Query: 2057 IKEIKESLMVLNSSEGKMPLEE-RI--QKIKEIILLKPEGDARI----ETIMKQAESSEA 2109
I E +E L+ + G + LE+ RI Q+++ I A + + I+++ ++
Sbjct: 1992 ITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADG 2051
Query: 2110 PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ---- 2165
+++ L ++ +WD + + Q +L E ++ ++ + L ++ L K +
Sbjct: 2052 SFLKEKLAGLNQRWD---AIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108
Query: 2166 -----EAGFALQHGLQEKKAQLKIYKKFLK------------------KAQDLTSLLKEL 2202
E G LQ L++ +++++ + LK + ++ L+ +
Sbjct: 2109 KRSTTELGENLQE-LRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTV 2167
Query: 2203 KSQGN--------YLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSY 2254
N L EC + PS + + H ++ + + S + D V+ H +
Sbjct: 2168 NMTWNKICREVPTTLKECIQEPSSVSQTRIA---AHPNVQKVVLVSSAS-DIPVQSHRTS 2223
Query: 2255 QVCV-TDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKK----- 2308
++ + DL+ T+ + V I ++++ + +R+ + L++
Sbjct: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
Query: 2309 --ILALAKSVKQNTSSVGQK-IIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKR 2365
+ LA+++K SS + I + ++ ++ + ++ + +Q++E + I+ S +
Sbjct: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLE---DMIIDSLQ 2340
Query: 2366 STEKKGKFTLPGREKQATSDVQESTQESAAVEKLEED----WEINKDSAVEMAMSKQLSL 2421
+ + + R+ +A + + + +++ ++ E+ + MA L
Sbjct: 2341 WDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQK 2400
Query: 2422 NAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ-TEC 2480
+E ++D R V E L+ + L + +A+ + LE +
Sbjct: 2401 LLEE--YGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKW 2458
Query: 2481 LNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALL 2540
+ + ET N+ A H +N LQ I ++ K+ ++D Q + A K++
Sbjct: 2459 IQEAETTV----NVLVDASHRENALQDSILARELKQQ----MQDIQAEIDAHNDIFKSID 2510
Query: 2541 TDKESL--KVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKK---- 2594
+++ + +G + T L ++ +LK K ++ H+ +K
Sbjct: 2511 GNRQKMVKALGNSEEATMLQH------RLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
Query: 2595 --LLESQIKQLEHGWEQVEQQ--IQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ 2650
LE IK L E++++Q I ++YD L ++++ E S+ +
Sbjct: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
Query: 2651 LRL-----KSPEE-RAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLED 2704
+ L ++PEE R QS LT + +A K ++ K +E++ K W +
Sbjct: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEK--W---------E 2673
Query: 2705 GINNLKKQWETLEPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDIL 2762
+N + W+ LE ++ D+ MKE A+++ P LL D +
Sbjct: 2674 SLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE----AESVRNGWKPVGDLLIDSLQ 2729
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
I K + I V+++ ++ ++ L + ++ L+DL ++++L +
Sbjct: 2730 DHIEKIMAFREEIAPINFKVKTV-NDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSV 2788
Query: 2823 TQRSQQLE 2830
R +QL+
Sbjct: 2789 DDRLKQLQ 2796
Score = 125 bits (315), Expect = 1e-27
Identities = 482/2660 (18%), Positives = 993/2660 (37%), Gaps = 458/2660 (17%)
Query: 3772 RAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLAN----PADYD--SLRTLSHHAS 3825
R E Q V ME L+ AW+ T + P D D SL+ L
Sbjct: 405 RVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHK 464
Query: 3826 TVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQI 3885
++Q LE + K N L + + +++ S T L +Q+L + TA+ + E ++
Sbjct: 465 SLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL 524
Query: 3886 QR-------MADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHL----KHGEVIL 3934
Q + ++ +++ + E+ ++K++T +F ++ L + ++
Sbjct: 525 QEINILWQELLEEQCLLKAWLTEKEEALNKVQTS-------NFKDQKELSVSVRRLAILK 577
Query: 3935 ENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVV 3994
E++ ++T+ ++ + Q QLL + K + + + EL
Sbjct: 578 EDMEMKRQTLDQLSE----------------IGQDVGQLLDNSKASKKINSDSEEL---- 617
Query: 3995 IKQTNEWDEEIENLKQILNNYSAQFSLEHMSP----DQADKLPQLQGEIERMEKQILSLN 4050
T WD ++ L+ N + + MS D + + + I + KQ L
Sbjct: 618 ---TQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPP 674
Query: 4051 Q--RKEDLLVDLKAT---------VLN-------------LHQHLKQEQEGVERDRLPAV 4086
+K + VD++A +LN + +++K + + +L A+
Sbjct: 675 PPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKAL 734
Query: 4087 TSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKH 4146
E+ ER +LN+ G + + E++ + + ++ E W ++ +H
Sbjct: 735 EKEQ---RERIPRADELNQTGQI-----LVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQH 786
Query: 4147 DKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLN----TEQGPECSLRPNQTE 4202
+D+E KI ++ A D L T++ +++
Sbjct: 787 LEDLER----------------KIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESS 830
Query: 4203 EGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLH---ACKTQVAELELWL---QQAN 4256
+ P ++ GL P++E R + ++ A + +L Q
Sbjct: 831 RQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQ 890
Query: 4257 VAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALS 4316
AVE D QQ LE +L G + H L+T KD Q L+
Sbjct: 891 EAVE------DRQQHLENELKG------QPGHAYLETLKTLKDVLNDSENKAQVSLNVLN 938
Query: 4317 LKLKTVKCNLEKVQMMLQEKHS-----EDQHPTILKKSSEPEHQEALQPVNLSELESIVT 4371
+L KV+ LQEK + E+Q P + K + E + E ++ +L
Sbjct: 939 --------DLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKL----- 985
Query: 4372 ERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQAS 4431
+ ++ D Q + +LK + KD E T + A +
Sbjct: 986 ----YKQEFDDVQGKWNKLKVLVSKDLHLLEEIAL-------------TLRAFEADSTVI 1028
Query: 4432 SPEND-VPDSILSPQGQNGDKWQYLHHELSS---------KIKLPLPQLVEPQVSTNMGI 4481
D V D ++ Q GD L +L I+ L + E + + G
Sbjct: 1029 EKWMDGVKDFLMKQQAAQGDD-AGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGP 1087
Query: 4482 LPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS 4541
+ + + L Y TQLE L +E + +++ + ++E NL K L E+ ++
Sbjct: 1088 VAGIKTW-----VQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMT 1142
Query: 4542 QCLSS-------------VEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588
Q +E +E + +ED ++V + L +K L + +
Sbjct: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQE 1202
Query: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648
L + EN LL LE + + L LD ++ N ++ +
Sbjct: 1203 LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWI----ELLHYLDLETTWLNTLE----E 1254
Query: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708
+KS L + K DA LE+ ES + D ++ L +
Sbjct: 1255 RMKSTEVLPE---------------KTDAVNEALESLESVLRHPADNRTQIRELGQTLID 1299
Query: 4709 VYKLEDVLDSMWGMLRARYTELS----SPFVTESQQDALLQGMVELVKIGKEKLAHGHLK 4764
L+D++ +RY +LS S ++ +Q +L+ +++++ +E L +
Sbjct: 1300 GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQ 1359
Query: 4765 QTKSKV----ALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVK 4820
T A Q E K+ + + A L ++ + L + E+ A +++
Sbjct: 1360 LTTYLTDRIDAFQVPQEAQKIQAE-ISAHELTLEELRRNMRSQPLTSPESRTARGGSQMD 1418
Query: 4821 ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
+L+ K R+ K Q L QK F++ ++ L+ + + L + + + + + +
Sbjct: 1419 VLQRKLREVSTKFQ-LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDK 1477
Query: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEG---QIAKLEEQWLSLNKKIDHELH 4937
++ + + + + G+ +V +G Q+ L+ + L ++
Sbjct: 1478 CMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQ 1537
Query: 4938 RLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKE 4997
L+ + +++ L++WL +++ L K S + DLDT S N K+
Sbjct: 1538 DLERASQLARKMKKEAASLSEWLSATETEL-VQKSTSEGLLGDLDTEISWAKNVL---KD 1593
Query: 4998 VDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL--HQLQ 5055
++++ + + L +L E L L W+ + T D L HQ Q
Sbjct: 1594 LEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQ 1653
Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
+E + + +W+ E + + + VK L+ E+D V
Sbjct: 1654 LEIFDGN--VAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVS-------ELDDANLQV 1704
Query: 5116 DFVNQSLLQLSTCDVESKRYERTEFAE-HLGEMNRQWHRVHGMLNRKIQHLEQLLESITE 5174
+ V L L S R E E L E+NR + +V QH++ I +
Sbjct: 1705 ENVRDQALILMNARGSSSR----ELVEPKLAELNRNFEKVS-------QHIKSAKLLIAQ 1753
Query: 5175 SENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYL 5234
E + L T + E+ + L DIEN L K L+ +
Sbjct: 1754 ------------EPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEK 1801
Query: 5235 TLESGAVPLLEDTASRIDELFQ------KRSSVLTQVNQLKTSMQSV----LQEWKIYDQ 5284
E A +E+ R +E+ K+ + Q+ L T + +Q+ K+ Q
Sbjct: 1802 MDEESAQ--IEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKM-GQ 1858
Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV----------ENLQSLQDEAESSEGSW 5334
L + + Y +E +K ++L ++ + + E+ +D ++ +
Sbjct: 1859 LASGIRSSLLPTDYLVEINK-ILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQL 1917
Query: 5335 EKLQEVIGKLKGLCPSV--------AEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
+KL E I + P V A I + + +W ++N+ +D+ ++
Sbjct: 1918 DKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEE 1977
Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
W+ + + + + E + L + G +L D++K +
Sbjct: 1978 WRQFHCDLNDLTQWITEAE---ELLVDTCAPGGSL----------------DLEKAR-IH 2017
Query: 5447 LQNSSVLDRLPQPAESSTHMLLPGPLHSLQRA--AYLEKMLLVKANEFEFVLSQFKDFGV 5504
Q V QP+ ++ + G + L +A ++L++ L ++ ++++ KD
Sbjct: 2018 QQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQP 2077
Query: 5505 RLESLKGLIMHEEENLDRL--------HQQEKENPDSFLNHVLALTAQSPDIEHLNEVSL 5556
RL+ +M LD + H +K + T +++ L +++
Sbjct: 2078 RLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRST----------TELGENLQELRDLTQ 2127
Query: 5557 KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEAL 5616
++ +V + L+ +NR T LE S+ + + L E+ +KI E+L
Sbjct: 2128 EM---EVHAEKLKWLNR-------TELEMLSD-KSLSLPER------------DKISESL 2164
Query: 5617 KV------DVANSLPELLEQQKTYKMLEAEVSINQT--IADSYVTQSLQLLDTTEIENRP 5668
+ + +P L++ ++ S++QT A V + + + ++I +
Sbjct: 2165 RTVNMTWNKICREVPTTLKE-----CIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQS 2219
Query: 5669 EFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKG 5728
+E S D+D + + D+ ++ + + S++++
Sbjct: 2220 HRTSEISI---------------PADLDKTITELADWLVLIDQMLK-----SNIVTVGDV 2259
Query: 5729 QERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL---LLTTDLKTKESVGRRIS 5785
+E + +K + ++R + L ++D++T ++ ++
Sbjct: 2260 EE------INKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRT--AITEKLE 2311
Query: 5786 QLQDSWKDME-------PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLP 5838
++++ W + QL +MI + ++ E+ +++ ++RL +L+ DPL
Sbjct: 2312 RVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLT 2371
Query: 5839 ELHEDLHNEKELIKELEQS----LASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHL 5894
+ + + + L++EL +A K L+ +D TR+V KE E+L
Sbjct: 2372 K---QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNV--------KETTEYL 2420
Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEE---- 5950
W +L +A R+ +E T + W+ + E V D S E
Sbjct: 2421 KTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQ 2480
Query: 5951 ------MIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA-SNKSRAAEIDDKLNKINDRW 6003
+++ +D EI+ ++ + +++KA N A + +L+ +N RW
Sbjct: 2481 DSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRW 2540
Query: 6004 QHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK--PVVYDVCDDQEIQK 6061
L S L+ + +L ++ L WL + EL K P+ DV +Q
Sbjct: 2541 NDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDV---PALQL 2597
Query: 6062 RLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTR-SLDRRWRNI 6120
+ + L+R++++ V + + V L D A E ++Q T + + R + I
Sbjct: 2598 QYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKI 2657
Query: 6121 CAMSMERRMKIEETWRL-------WQKFLD-------DYSRFEDWLKSAERTAACPNS-- 6164
++ +++E W WQK +D D D L + + A +
Sbjct: 2658 AKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGW 2717
Query: 6165 ---SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
++L S ++ +++ AF+ +I +++ +N +L+ + + ++ + + +
Sbjct: 2718 KPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLD-LHPSLKMSRQLDD 2776
Query: 6222 GNQRWDNLQRRVTAVLRRLR 6241
N RW LQ V L++L+
Sbjct: 2777 LNMRWKLLQVSVDDRLKQLQ 2796
Score = 125 bits (314), Expect = 1e-27
Identities = 301/1561 (19%), Positives = 609/1561 (39%), Gaps = 209/1561 (13%)
Query: 4894 RLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDS 4953
R Y+ E + + + PE E + + E S ++D +L Q L+ +L+
Sbjct: 271 RKYKKECEEEAINIQSTAPEEEHESPRAETP--STVTEVDMDLDSYQIALEEVLT----- 323
Query: 4954 DQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGN 5013
WL S++ T ++EQ ++S D++ ++ F E+ S +V+ GN
Sbjct: 324 -----WLLSAEDT---FQEQD-DISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGN 374
Query: 5014 QLLH---LKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
QL+ L + + ++ + +W L + D Q +LH + ME +K + ++ +
Sbjct: 375 QLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMEL--QKKQLQQLSA 432
Query: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
W+ E + ++ ++ LL++HK + +++ +Q V+ + ++ +
Sbjct: 433 WLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSG 492
Query: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
ES + + LGE +W V + L+++ E + +L WL +E
Sbjct: 493 ESATAILEDQLQKLGE---RWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549
Query: 5191 ERLKTLQ------KPESVISVQKLLLDCQDIENQLAIKSKALDELKQ-----SYLTLESG 5239
E L +Q + E +SV++L + +D+E +K + LD+L + L S
Sbjct: 550 EALNKVQTSNFKDQKELSVSVRRLAILKEDME----MKRQTLDQLSEIGQDVGQLLDNSK 605
Query: 5240 AVPLL----EDTASRIDELFQKRSSVLTQVNQLKTSM-------QSVLQEWKIYDQLYDE 5288
A + E+ R D L Q+ QV Q + + +L+ ++ +Q +
Sbjct: 606 ASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITK 665
Query: 5289 VNMMTI---------RFWYCMEHSKPV-VLSLETLRCQVENLQSLQDEAESSEGSWEKLQ 5338
+ + + +E K +S E L ++ ++Q +
Sbjct: 666 KSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTS 725
Query: 5339 EVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQK----AQSLLQLWKAYSNAH 5394
E+ KLK L E I + Q Q + +Q+ K + + + + S+
Sbjct: 726 EMKKKLKALEKEQRERIPRADE-----LNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEW 780
Query: 5395 GEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLD 5454
+ L+ E K Q +I+ L E+ V KTKE +++++S+ +
Sbjct: 781 KNVSQHLEDLERKIQLQEDINAYFKQLDEL------------EKVIKTKEEWVKHTSISE 828
Query: 5455 R----LPQPAESS----THMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL 5506
LP +S T++L P + RA+ L+ + + +FV F F R
Sbjct: 829 SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASC--SALMSQPSAPDFVQRGFDSFLGRY 886
Query: 5507 ESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVK 5566
++++ + +++L+ ++ + + ++L + L D E+ +VSL + L+D+A
Sbjct: 887 QAVQEAVEDRQQHLE--NELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNV-LNDLA-- 941
Query: 5567 TLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPE 5626
AL+ L I N+K L K+ E K N P+
Sbjct: 942 -----------KVEKALQEKKTLDEILENQK---------PALHKLAEETKALEKNVHPD 981
Query: 5627 LLEQQKTYKMLEAEVSINQTIADSYVTQSLQLL------------DTTEIENRPEFITEF 5674
+ +K YK +V V++ L LL D+T IE + + +F
Sbjct: 982 V---EKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDF 1038
Query: 5675 SKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT-SHLLSAVKG--QER 5731
Q G++++ V + + +S++N+ T+ S ++ +K Q R
Sbjct: 1039 LMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTR 1098
Query: 5732 FSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSW 5791
YQT+ E +KEI Q+ R + + A K L + + +
Sbjct: 1099 LGDYQTQL---EKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEY 1155
Query: 5792 KDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ----SEDPLPELHEDLHNE 5847
K E +L +++ + E Q E ++K LK +++L A+ ++ EL+ L N
Sbjct: 1156 KSPE-ELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENY 1214
Query: 5848 KELIKE-------LEQSLASWTQNLKELQTMKADL--------TRHVLVEDVMVLKEQIE 5892
+ L LE+ + W + L L L + VL E + E +E
Sbjct: 1215 QLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALE 1274
Query: 5893 HLHRQWEDLCLRVAIRKQEIEDRLNTWV--------------VFNEKNKELCAWLVQMEN 5938
L E + A + +I + T + FN + ++L +
Sbjct: 1275 SL----ESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQI 1330
Query: 5939 KVLQTADI--SIEEMIEKLQKDCME---EINLFSENKLQLKQMGDQLIKASNKSRAAEID 5993
+ + + ++M++ LQ+ E ++ + +++ Q+ + K + A E+
Sbjct: 1331 SLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELT 1390
Query: 5994 DKLNKINDRWQHL-------------FDVIGSRVKKLKETFAFIQQ---LDKNMSNLRTW 6037
+ + N R Q L DV+ +++++ F Q+ ++ M + +
Sbjct: 1391 LEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRV 1450
Query: 6038 LARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDAC 6097
L +++EL V DV D IQ L + L + + + VE+V ++
Sbjct: 1451 LDGVKAELHVLDVKDV-DPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQT- 1508
Query: 6098 ANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER 6157
+ + SL + ++ A E + +E +L +K + + +WL + E
Sbjct: 1509 ---DNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATET 1565
Query: 6158 TAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR-LK 6216
++SE L E+ + + + +R L I + L +N + + L+
Sbjct: 1566 ELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL--QNLIEGSEPILE 1623
Query: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE 6276
+ + N W ++ L + NQ E F+G I WL + + L +E
Sbjct: 1624 ERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPT 1683
Query: 6277 SDADDKMRQLNGFQQEITLNTNKI-DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
S ++ +++L + L + DQ ++ L+ L+E +L EL+R ++
Sbjct: 1684 SKQEEIVKRLVSELDDANLQVENVRDQALI----LMNARGSSSRELVEPKLAELNRNFEK 1739
Query: 6336 V 6336
V
Sbjct: 1740 V 1740
Score = 110 bits (274), Expect = 6e-23
Identities = 361/1938 (18%), Positives = 753/1938 (38%), Gaps = 270/1938 (13%)
Query: 4482 LPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS 4541
LP+ + N + E K + LEDL ++ +Q QE++ AY K+L EL
Sbjct: 764 LPTEEIKNVLEKVSSEWKNVSQHLEDLERK---IQLQEDIN--AYF---KQLDEL----E 811
Query: 4542 QCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDK----KGDLLKAMTWPG 4597
+ + + EE ++ + ++ EL L L L K + M+ P
Sbjct: 812 KVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNL-LGLHPKIEMARASCSALMSQPS 870
Query: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL--DYNRSYQNEIKRLYHQLIKSKTS 4655
+ + FD+ + Q A R + L+ L +Y +K L L S+
Sbjct: 871 A-PDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK 929
Query: 4656 LQQSLNEISGQSVAEQ-LQKADAYTVELENAESRVAKLRDEGERLHLP-YALLQEVYKLE 4713
Q SLN ++ + E+ LQ+ LEN + + KL +E + L + ++++YK E
Sbjct: 930 AQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQE 989
Query: 4714 -DVLDSMWGMLRARYT-------ELSSPFVTESQQDALLQGMVELVK--IGKEKLAHG-- 4761
D + W L+ + E++ +++ ++ VK + K++ A G
Sbjct: 990 FDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDD 1049
Query: 4762 -----HLKQTKSKV----ALQAQIENHKVFFQKLVADMLL-IQAYSAKILPSLLQNRETF 4811
L Q + V +++ ++N K L + + I+ + L E
Sbjct: 1050 AGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKL 1109
Query: 4812 WAEQVTEVKILEEKSRQCGMKLQSL--LQKW-EEFDENYASLEKDLEILISTLPSVSLVE 4868
E T+ L E + + L +Q+W + +E Y LE+D E S S VE
Sbjct: 1110 SKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEY--LERDFEYK-SPEELESAVE 1166
Query: 4869 E---TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS---------CPELEG 4916
E +E ++++ + +K NI A++ + G++L + ++ C + G
Sbjct: 1167 EMKRAKEDVLQKEVRVKILKDNIKLLAAKVP---SGGQELTSELNVVLENYQLLCNRIRG 1223
Query: 4917 QIAKLEEQW---LSLNKKIDHE---LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ LEE W + L +D E L+ L+ +K +D + + LES + L +
Sbjct: 1224 KCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHP 1283
Query: 4971 KEQSLNVSQ---------DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKET 5021
+ + + LD I S F S+ D ++ IS+ QL L+ET
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDDIISEKLEAFN-SRYEDLSHLAESKQISLEKQLQVLRET 1342
Query: 5022 DTA--TLRASLAQFEQKWTMLIT------QLPDIQEKL------HQLQMEKLPSRKAITE 5067
D L+ SL + +++ T +T Q+P +K+ H+L +E+L
Sbjct: 1343 DQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQP 1402
Query: 5068 MISWMNNVEHQTSDEDSVHSPSSASQVK-HLLQKHKEFRMEMDYKQWIVDFVNQSLLQLS 5126
+ S + S D + K L QK F M + ++D V L L
Sbjct: 1403 LTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLD 1462
Query: 5127 TCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWL 5186
DV+ + HL + + L + + ++ +E++ ++ I
Sbjct: 1463 VKDVDPDVIQT-----HLDKCMK--------LYKTLSEVKLEVETVIKTGRHI------- 1502
Query: 5187 EAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLED 5246
Q+++ + + ++ K+L + D+ Q+ + L+ Q ++ A L E
Sbjct: 1503 -VQKQQTDNPKGMDEQLTSLKVLYN--DLGAQVTEGKQDLERASQLARKMKKEAASLSEW 1559
Query: 5247 TASRIDELFQKRSS--VLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK 5304
++ EL QK +S +L ++ + ++VL++ + + + + +E S+
Sbjct: 1560 LSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSE 1619
Query: 5305 PVVLSLETLRCQVENLQSLQDEAESSEGSW-EKLQEVIGKLKGLCPSVAEIIEEKCQNTH 5363
P+ LE C L + + W L +L+ +VA I
Sbjct: 1620 PI---LEERLCV---LNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHI--------- 1664
Query: 5364 KRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAE 5423
W +A+ D+++K + Q A L+ + + Q L ++ G++ E
Sbjct: 1665 STWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRE 1724
Query: 5424 ILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
++ P L ++ +++ Q +S+ ++ PL+
Sbjct: 1725 LVEPKLAELNRN-----------------FEKVSQHIKSAKLLIAQEPLYQC-------- 1759
Query: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTA 5543
LV FE + F D ++ ++ E++L+ + EK + +S A
Sbjct: 1760 --LVTTETFETGVP-FSDLEKLENDIENMLKFVEKHLESSDEDEKMDEES---------A 1807
Query: 5544 QSPDIEHLNEVSLKLPLSDVAVKTLQN----MNRQWIRATATALER------CSELQGIG 5593
Q ++ E L P+ D + ++ ++ ++ + A +++ S ++
Sbjct: 1808 QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSL 1867
Query: 5594 LNEKFLYCCEKWIQLLEKIEEALKVDVANSL--PELLEQQKTYKMLEAEVS-INQTIADS 5650
L +L K + ++ +E +L V N+ + Q+ + K ++ ++ + + IA
Sbjct: 1868 LPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVI 1927
Query: 5651 YVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVE 5710
+ Q +L+ + E + ++L +W + RKG D + +W+ F +
Sbjct: 1928 HEKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLN 1986
Query: 5711 NLFRFLTDTSHLL--SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL 5768
+L +++T+ LL + G SL ++ IH+ + E+ + + A G+ +
Sbjct: 1987 DLTQWITEAEELLVDTCAPGG---SLDLEKARIHQ-QELEVGISSHQPSFAALNRTGDGI 2042
Query: 5769 LLTTDLKTKESVGRRISQLQDSW-------KDMEPQLAEMIKQFQSTVETWDQCEKKIKE 5821
+ + +++ L W KD +P+L KQ D+ + +
Sbjct: 2043 VQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTK 2102
Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLT--RHV 5879
+ +Q + EL E+L ++L +E+E + LK L + ++ + +
Sbjct: 2103 AEHAMQ------KRSTTELGENLQELRDLTQEMEVH----AEKLKWLNRTELEMLSDKSL 2152
Query: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVA-----------------------IRKQEIEDRL 5916
+ + + E + ++ W +C V ++K +
Sbjct: 2153 SLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSA 2212
Query: 5917 NTWVVFNEKNKELCAWLVQMENKVLQTAD--ISIEEMIEK--LQKDCMEEINL----FSE 5968
+ V + + E+ ++ + + AD + I++M++ + +EEIN
Sbjct: 2213 SDIPVQSHRTSEISI-PADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKI 2271
Query: 5969 NKLQLKQMGDQLI-----------KASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
K L+Q QL KAS+ I +KL ++ ++W + R ++L
Sbjct: 2272 TKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQL 2331
Query: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
++ Q D + + + E+ L + + K++++ Q L +++
Sbjct: 2332 EDMIIDSLQWDDHREETEELMRKYEARL---YILQQARRDPLTKQISDNQILLQELGPGD 2388
Query: 6078 AGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRL 6137
V + N+ LL + + + ++++TT L W N+ +R+ +E WR
Sbjct: 2389 GIVMAFDNVLQKLLEEYGS----DDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
Query: 6138 WQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTS--AKEELKRFEAFQRQIHERLT 6191
Q D F W++ AE T + L S A+E ++ + Q +I
Sbjct: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
Query: 6192 QLELINKQYRRLARE-NRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEF 6250
+ I+ +++ + ++ A+ L+ + + NQRW++L+ + ++ L +
Sbjct: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
Query: 6251 EGTRESILVWLTEMDLQL 6268
+ E ++ WL D +L
Sbjct: 2565 LMSLEELIKWLNMKDEEL 2582
Score = 90.9 bits (224), Expect = 4e-17
Identities = 471/2469 (19%), Positives = 971/2469 (39%), Gaps = 410/2469 (16%)
Query: 1872 EQKLQKLSDFLTLEGRNSKIKQVD--SVLKHVKKHLPKAHVKELISWLVGQEFELEKMES 1929
E ++Q+ L +++ +D S L V L K +++L +WL E ++KME+
Sbjct: 387 EFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMET 446
Query: 1930 ICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM--------EEPGEK-TELFC 1980
L+D ++ L +L ++H++L+ L ++ K + E GE T +
Sbjct: 447 C------PLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILE 500
Query: 1981 QALARKREQFESVAQLN----NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEED 2036
L + E++ +V + N L+E +E ++E CL+ + T E+E+
Sbjct: 501 DQLQKLGERWTAVCRWTEERWNRLQEINILWQE--LLEEQCLLKAWLT--------EKEE 550
Query: 2037 KLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLE-ERIQKIKEI------ILL 2089
L + +F D KE+ S+ L + M ++ + + ++ EI +L
Sbjct: 551 ALNKVQTSNFKDQ--------KELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLD 602
Query: 2090 KPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSH-QEKLLLEGEKYL 2148
+ +I + ++ LVQ+ L D SNQ T +A +S +K LLE +
Sbjct: 603 NSKASKKINSDSEELTQRWDSLVQR-LEDSSNQ--VTQAVAKLGMSQIPQKDLLETVR-- 657
Query: 2149 QSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNY 2208
+R I K KQE L KK Q+ + + KK +++ L +
Sbjct: 658 -----VREQAITKKSKQE----LPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKT 708
Query: 2209 LLECTKNPSFSE-EPWLEIKHLHESLLQQLQDSVQNLDG-------HVREHDSYQVCVTD 2260
++ T+ + + + E+K ++L ++ ++ + D V + + +
Sbjct: 709 AIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEE 768
Query: 2261 LNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNT 2320
+ L+ S E+ + S D +E K+Q LQE N Q L+K++ + ++T
Sbjct: 769 IKNVLEKVSSEWKNVSQHLED---LERKIQ-LQEDINAYFKQLDELEKVIKTKEEWVKHT 824
Query: 2321 SSVGQKIIKDDIKSLQCK-QKDLENRLA-SAKQEMECCLNSILKSKRSTE---KKGKFTL 2375
S + + + SL+ Q++L N L K EM S L S+ S ++G +
Sbjct: 825 SI--SESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSF 882
Query: 2376 PGREKQATSDVQESTQE----------SAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQE 2425
GR + V++ Q A +E L+ ++ DS + +S + + +
Sbjct: 883 LGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAK 942
Query: 2426 SMKNTEDERKVNE-LQNQPLELDTM------LRNEQLEEIEKLYTQ----LEAKKAAIKP 2474
K ++++ ++E L+NQ L + L ++EKLY Q ++ K +K
Sbjct: 943 VEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKV 1002
Query: 2475 LEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKES----------QYCVLRD 2524
L + L+ E AL L + ++ + + +++ Q
Sbjct: 1003 LVSKD-LHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
Query: 2525 FQEYLAAVESSMKALLTDKESLKVGPL------------DSVTYLDKIKKFIAS----IE 2568
F + +ESS+K + + +L+ GP+ D T L+K+ K IA+ +
Sbjct: 1062 FVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLS 1121
Query: 2569 KEKDSLGNLKIKWENLSNHVTDMDKKL------------LESQIKQLEHGWEQVEQQI-- 2614
+ ++ NLK + +T +++ LES +++++ E V Q+
Sbjct: 1122 ESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVR 1181
Query: 2615 -------------------QKKYSQQVVEYDEFTTLMNKVQDTEISLQ-------QQQQH 2648
Q+ S+ V + + L N+++ +L+ + +
Sbjct: 1182 VKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY 1241
Query: 2649 LQLR---LKSPEERAGNQSMIALTTDL--QATKHGFSVLKGQA-------ELQMKRIWGE 2696
L L L + EER + ++ TD +A + SVL+ A EL I G
Sbjct: 1242 LDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGG 1301
Query: 2697 KEKKNLEDGINNLKKQWETLEPLHLEAENQI---KKCDIRNKMKETILWAKNLLGELNPS 2753
+ + + ++E L HL QI K+ + + + + + LGEL+
Sbjct: 1302 ILDDIISEKLEAFNSRYEDLS--HLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQ 1359
Query: 2754 IPLLPDDILSQI---RKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLED 2810
+ D + ++ + I A + ++E L ++ + LT+ E
Sbjct: 1360 LTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQ--PLTSPES-------RT 1410
Query: 2811 LRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAE- 2869
R QM VL+ R +F+L ++ F Q M+ L + E + +
Sbjct: 1411 ARGGSQMDVLQRKLREVSTKFQLFQKPANFE-----QRMLDCKRVLDGVKAELHVLDVKD 1465
Query: 2870 -----LKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRT 2924
++ H K L E+ + T ++ +I ++ +++QL +LK+
Sbjct: 1466 VDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLY 1525
Query: 2925 NRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQE-----EADSIQRNE---LL--LNQEVN 2974
N + + ++E + R+ ++ ++L E E + +Q++ LL L+ E++
Sbjct: 1526 NDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEIS 1585
Query: 2975 --KGVKEEIYNLKDRLTAI--------------------KCCILQV-LKLKKVFDYIGLN 3011
K V +++ K L I + C+L + + N
Sbjct: 1586 WAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCN 1645
Query: 3012 WDFSQLDQLQ----------TQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQ 3061
+ +QL+ T +++ E L+E K+ + +EE K L+S++ +LQ
Sbjct: 1646 TLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVK--RLVSELDDANLQ 1703
Query: 3062 IKKMTE---VVLKAPDSS------PESRRLNAQI--LSQRIEKAKCLC--DEIIKKLNEN 3108
++ + + +++ A SS P+ LN +SQ I+ AK L + + + L
Sbjct: 1704 VENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTT 1763
Query: 3109 KTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQI 3168
+TF+ ++ +KL ++NM L+ K L+ + +K++ +
Sbjct: 1764 ETFETGVPFSDL----------EKLENDIENM-LKFVEKHLESSDEDEKMD-------EE 1805
Query: 3169 KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVET 3228
+Q+++ L E+ H E + E + Q+ + AI Q+ + AS + +
Sbjct: 1806 SAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRS 1865
Query: 3229 KLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGN 3288
L D +++N + + D E E T E D
Sbjct: 1866 SLLP-TDYLVEINKIL-----LCMDDVELSLNVPELNTAIYE--------------DFSF 1905
Query: 3289 PEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFK 3348
E+SL+ + ++L +A I + + + +S +Q++ TL +L +K + +
Sbjct: 1906 QEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYS 1965
Query: 3349 AQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS---SLPLSYREALERLEQSKA 3405
++ +R +E ++ + D+ +++ E +L + + SL L R+ Q +
Sbjct: 1966 DRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLE----KARIHQQE- 2020
Query: 3406 LVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCE 3465
L + S + L + + + ++ DG L + ++ L ++W +++ K+ +
Sbjct: 2021 LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQ---P 2077
Query: 3466 ELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ 3525
LK E K V + + I+ L + + K E L EL D + + EK +
Sbjct: 2078 RLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLK 2137
Query: 3526 LL----LTLLLQRIRSIQNVPESSGAVETV-PAFQEITSMKERCNKLLQKVQKNKELVQT 3580
L L +L + S+ + S ++ TV + +I +E L + +Q+ + QT
Sbjct: 2138 WLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKI--CREVPTTLKECIQEPSSVSQT 2195
Query: 3581 EIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEEL-------QSILKKGKL 3633
I H ++++ + + S + + + EL +LK +
Sbjct: 2196 RI-AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIV 2254
Query: 3634 TFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIE 3693
T ++ E++ S M I A++E + + + + + N+ S A+ K+E
Sbjct: 2255 TVGDV-EEINKTVSRM-KITKADLEQRHPQLDYVF-TLAQNLKNKASSSDMRTAITEKLE 2311
Query: 3694 EINN----GLHNVEKMLQQKSKNI----------EKAQEIQKKMWDEL-DLWHSKLNELD 3738
+ N H VE QQ I E+ +E+ +K L L ++ + L
Sbjct: 2312 RVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLT 2371
Query: 3739 SEVQD----IVEQDPGQAQEWMDNLMIPFQQYQQ--VSQRAECRTSQLNKATVKMEEYSD 3792
++ D + E PG D +++ F Q + + T + + T ++
Sbjct: 2372 KQISDNQILLQELGPG------DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWI 2425
Query: 3793 LLKSTEAWIENTSH-----LLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
LK + A +N + A+ D ++ A T L D+ + N L +
Sbjct: 2426 NLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILA 2485
Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESL------PQIQRMADDVVAIESEVKS 3901
E + + + ++ + +QK++++L +Q DD+ +++K+
Sbjct: 2486 RELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKA 2545
Query: 3902 --------MEKRVSKIKTILLS-KEIFDF--SPEEHLKHGEVILENIRPMKKTIAEIVSY 3950
+E K +L+S +E+ + +E LK I ++ ++ +
Sbjct: 2546 KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKAL 2605
Query: 3951 QVELRLPQTGM-------------KPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQ 3997
+ EL+ + + +P+ + + LQ K + ++ K + KQ
Sbjct: 2606 RRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS-KTELTPEERAQKIAKAMRKQ 2664
Query: 3998 TNEWDEEIENLKQILNNYSAQFSLEHMSPDQA-DKLPQLQGEIERMEKQILSLNQRKE-- 4054
++E E+ E+L + +N+ Q D+A +KL LQG ++ ++ + +
Sbjct: 2665 SSEVKEKWESLNAVTSNWQKQV-------DKALEKLRDLQGAMDDLDADMKEAESVRNGW 2717
Query: 4055 ----DLLVD 4059
DLL+D
Sbjct: 2718 KPVGDLLID 2726
Score = 90.1 bits (222), Expect = 7e-17
Identities = 482/2703 (17%), Positives = 1032/2703 (38%), Gaps = 477/2703 (17%)
Query: 2577 LKIKWENLSNHVTDMDKK------LLESQIKQLEH--GWEQV-EQQIQKKYSQQVVEYDE 2627
L +WE L V MD++ L+E Q KQL+ W + E++IQK + D+
Sbjct: 397 LNARWEAL--RVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQK---METCPLDD 451
Query: 2628 FTTLMNKVQDTEISLQQQQQHLQLRLKS-------PEERAGNQSMIALTTDLQATKHGFS 2680
+ K+ + SLQ + Q+++ S +E +G + L LQ ++
Sbjct: 452 DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWT 511
Query: 2681 VLKGQAELQMKRI------WGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRN 2734
+ E + R+ W E ++ L K W T + EA N+++ + ++
Sbjct: 512 AVCRWTEERWNRLQEINILWQELLEEQC------LLKAWLTEKE---EALNKVQTSNFKD 562
Query: 2735 KMKETILWAKNL----------------LGELNPSIPLLPDDILSQIRKCKVTHDGILAR 2778
+ KE + + L L E+ + L D+ + +K + + R
Sbjct: 563 Q-KELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKAS-KKINSDSEELTQR 620
Query: 2779 QQSVESLAEEVKDKVPSLTTYEGSDL---NNTLEDLRNQYQMLVLKSTQ--------RSQ 2827
S+ E+ ++V G + LE +R + Q + KS Q + +
Sbjct: 621 WDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKR 680
Query: 2828 QLEFKLEERSNFFAI-------IRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
Q+ +E + F AI I K++ +Q +E +++ + E+K LE
Sbjct: 681 QIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTS---EMKKKLKALEKE 737
Query: 2881 QKE-LQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVE 2939
Q+E + D L + I E E L E+ +KN+ + + + + ++E
Sbjct: 738 QRERIPRADE-----LNQTGQILVEQMGKEGLPTEE-IKNVLEKVSSEWKNVSQHLEDLE 791
Query: 2940 HKIKFCRQFHEKTSALQEEADSIQR-----NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
KI Q E +A ++ D +++ E + + +++ ++ + +LKD
Sbjct: 792 RKI----QLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQ----- 842
Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
+++ + +GL+ + + + + + D+F G+YQA+
Sbjct: 843 -------RELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFL---GRYQAVQEA 892
Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCD------EIIKKLNEN 3108
+ D Q E+ + + E+ + +L+ KA+ + ++ K L E
Sbjct: 893 VE--DRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEK 950
Query: 3109 KTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQ-DKLET----SLH 3163
KT D+ + ++ KL AEE L K + V +L +E D+ + +KL+ LH
Sbjct: 951 KTLDEILENQKPALHKL-AEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLH 1009
Query: 3164 VLNQI---------------------KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAE 3202
+L +I K L + + +Q + D C AF ++
Sbjct: 1010 LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETI 1069
Query: 3203 MCSIKAVTAIEKQREEN--SSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTR 3260
S+K + IE + + V+T+L +++ +L+ I + + L+++ E
Sbjct: 1070 ESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAAN 1129
Query: 3261 YKEAVTRAVESITSLEAIIIPYRVDVGNPEE---SLEMPLRKQEELESTVAHIQDLTEKL 3317
K+ + E +T E + + +PEE ++E R +E++ ++ L + +
Sbjct: 1130 LKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNI 1189
Query: 3318 GMISS--PEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNL 3375
++++ P +L L ++ + + + E E + C+ ++ +
Sbjct: 1190 KLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLE---EVWSCWIELLHYLDLET 1246
Query: 3376 SKMETVLGQSMSS--LPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433
+ + T+ + S+ LP E LE ++++ + + ++ +L Q L
Sbjct: 1247 TWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI-------- 1298
Query: 3434 NDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP 3493
DG L I+S E + S E L +L E
Sbjct: 1299 -DGGILDDIISEKLEAFNSRYED----------------------------LSHLAES-K 1328
Query: 3494 EISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPA 3553
+IS K+ E ++L L + ++KQ L T L RI + Q VP+ + ++ +
Sbjct: 1329 QISLEKQLQVLRETDQMLQVLQESLGELDKQ--LTTYLTDRIDAFQ-VPQEAQKIQAEIS 1385
Query: 3554 FQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQD 3613
E+T + R N +++ L E + + ++ L+ ++ +T FQ
Sbjct: 1386 AHELTLEELRRN------MRSQPLTSPESRTARGGS-QMDVLQRKLREVSTKFQLF---- 1434
Query: 3614 HPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDE 3673
+K FE+ K+ + + +L + ++ + P I++ +++C K + + E
Sbjct: 1435 --QKPANFEQRMLDCKR---VLDGVKAELHVL--DVKDVDPDVIQTHLDKCMKLYKTLSE 1487
Query: 3674 -KISNEVLKSSPSYAMRRKIEEINNGL-----------HNVEKMLQQKSKNIEKAQEIQK 3721
K+ E + + + ++++ + G+ +++ + + +++E+A ++ +
Sbjct: 1488 VKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLAR 1547
Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLN 3781
KM E L+ ++E +V++ + + +L + V + E R + LN
Sbjct: 1548 KMKKEAASLSEWLSATETE---LVQKSTSEGL--LGDLDTEISWAKNVLKDLEKRKADLN 1602
Query: 3782 KATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQ--KHN 3839
T +L++ +E +E L A + +RT + M ++ + N
Sbjct: 1603 TITESSAALQNLIEGSEPILEE--RLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGN 1660
Query: 3840 LLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEV 3899
+ H + +++ E ++ S QE V L ++ ++ Q++ + D + +
Sbjct: 1661 VAHISTWLYQAEALLDEIEKKPTSKQE--EIVKRLVSELDDANLQVENVRDQALIL---- 1714
Query: 3900 KSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ--VELRLP 3957
M R S S+E+ + E ++ E + ++I+ K IA+ YQ V
Sbjct: 1715 --MNARGSS------SRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETF 1766
Query: 3958 QTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSA 4017
+TG+ D++ LEN +IEN+ + + +
Sbjct: 1767 ETGVP-----------FSDLEKLEN---------------------DIENMLKFVEKH-- 1792
Query: 4018 QFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEG 4077
LE S D+ +K+ + +IE + QR E++L HQ ++ ++
Sbjct: 1793 ---LE--SSDEDEKMDEESAQIEEVL-------QRGEEML----------HQPMEDNKKE 1830
Query: 4078 VERDRLPAVTSEEGGVAERDASERKLNR--RGSMSYLAAVEEEVEESSVKSDNGDEKAEP 4135
R +L + + + +RK+ + G S L + VE + + D +
Sbjct: 1831 KIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSL 1890
Query: 4136 SPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC- 4194
+ ++ D +ED + +++ K+ ++ PD + GPE
Sbjct: 1891 NVPELNTAIYEDFSFQEDSLKN-----IKDQLDKLG-EQIAVIHEKQPDVILEASGPEAI 1944
Query: 4195 SLRPNQTEEGTTPPIEADTLDS--SDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWL 4252
+R T+ + D ++ SD +G + +E+ R H + +L W+
Sbjct: 1945 QIRDTLTQLNA----KWDRINRMYSDRKGCFDRAMEEWRQ-----FHC---DLNDLTQWI 1992
Query: 4253 QQA-----NVAVEPETLNADMQQVLEQQL-VGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
+A + +L+ + ++ +Q+L VG + H+ +F G+
Sbjct: 1993 TEAEELLVDTCAPGGSLDLEKARIHQQELEVGISS------HQPSFAALNRTGDGIVQKL 2046
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+ +A+ LK K N ++ + K + + K+ + HQ L E+
Sbjct: 2047 S---QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQ-------LDEI 2096
Query: 4367 ESIVTERPQFSRQKDFQQQQVLELKP--MEQKDFIKFIEFNAKKMWPQYCQHDNDTTQES 4424
+T+ + Q++ EL E +D + +E +A+K+ + N T E
Sbjct: 2097 ICWLTKA-----EHAMQKRSTTELGENLQELRDLTQEMEVHAEKL-----KWLNRTELEM 2146
Query: 4425 SASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPS 4484
+ S PE D L W + E+ + +K + ++ S + + +
Sbjct: 2147 LSDKSLSLPERDKISESLRTVNMT---WNKICREVPTTLK----ECIQEPSSVSQTRIAA 2199
Query: 4485 VTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYI--NLDKKLFEL---FLT 4539
+P +++ L AS++ Q + T E I +LDK + EL +
Sbjct: 2200 -------HPNVQKVV--------LVSSASDIPVQSHRTSEISIPADLDKTITELADWLVL 2244
Query: 4540 LSQCLSS-------VEEM------LEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK 4586
+ Q L S VEE+ +++ + E Q + TLA LK
Sbjct: 2245 IDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN-----KASS 2299
Query: 4587 GDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL------DYNRSYQN 4640
D+ A+T E + ++ + TQ R + L+ + D +R
Sbjct: 2300 SDMRTAIT----------EKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETE 2349
Query: 4641 EIKRLYHQ--LIKSKTSLQQSLNEIS-GQSVAEQLQKADAYTVELENAESRVAK------ 4691
E+ R Y I + +IS Q + ++L D + +N ++ +
Sbjct: 2350 ELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDD 2409
Query: 4692 ---LRDEGERLHLPYA-LLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGM 4747
+++ E L + L Q + ++ L++ W ++A +L + + + + +
Sbjct: 2410 TRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVL 2469
Query: 4748 VELV---KIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVAD-MLLIQAYSAKILPS 4803
V+ ++ + LKQ + QA+I+ H F+ + + +++A +
Sbjct: 2470 VDASHRENALQDSILARELKQQMQDI--QAEIDAHNDIFKSIDGNRQKMVKALGNSEEAT 2527
Query: 4804 LLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPS 4863
+LQ+R ++ ++K KS L++ +KW + L K L + L
Sbjct: 2528 MLQHRLDDMNQRWNDLKA---KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKK 2584
Query: 4864 VSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVAS--VSCPE-------- 4913
+ L + + ++R + K + +++ + +A + PE
Sbjct: 2585 QMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS 2644
Query: 4914 ----------------LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLT 4957
+ Q ++++E+W SLN + ++ L+ L D L
Sbjct: 2645 KTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLD 2704
Query: 4958 KWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLH 5017
++ ++ N WK +D+++ +I F +E+ + V + +QL
Sbjct: 2705 ADMKEAESVRNGWKPVG---DLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761
Query: 5018 LKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRK---AITEMISWMNN 5074
L + + L +W +L + D ++L + + PS + + + + W +
Sbjct: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRS 2821
Query: 5075 VEH 5077
+ H
Sbjct: 2822 ISH 2824
Score = 86.3 bits (212), Expect = 1e-15
Identities = 262/1412 (18%), Positives = 545/1412 (38%), Gaps = 179/1412 (12%)
Query: 4775 QIENHKVFFQKLVADML----LIQAYSAKILPSLLQNRETFWA-EQVT------EVKILE 4823
Q H+ F +L A ++QA + I L + E F EQ+T E +E
Sbjct: 348 QFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVE 407
Query: 4824 EKSRQCGMK--LQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFY 4881
RQ + L L +K + + +L ++ + T P V+ ++ L E S
Sbjct: 408 SMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQ 467
Query: 4882 -----QQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHEL 4936
+Q+K N H + N G+ A LE Q+ KL E+W ++ + +
Sbjct: 468 SDLEAEQVKVN-SLTHMVVIVDENSGESATAI-----LEDQLQKLGERWTAVCRWTEERW 521
Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
+RLQ + + L WL + LN K Q+ N +D + ++ +
Sbjct: 522 NRLQEINILWQELLEEQCLLKAWLTEKEEALN--KVQTSNF-KDQKELSVSVRRLAILKE 578
Query: 4997 EVDEKSSLKTAVISIGNQLLHLKETDTAT--LRASLAQFEQKWTMLITQLPDIQEKLHQ- 5053
+++ K + IG + L + A+ + + + Q+W L+ +L D ++ Q
Sbjct: 579 DMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQA 638
Query: 5054 ---LQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF-RMEMD 5109
L M ++P + + + + ++ E P Q+ ++ K+F + +
Sbjct: 639 VAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAE 698
Query: 5110 YKQWIVDF--------VNQSLLQLSTCDVESK----------RYERTE--------FAEH 5143
WI+ + + + + T +++ K R R + E
Sbjct: 699 LLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQ 758
Query: 5144 LGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI---LNNWLEAQEERLKTLQKPE 5200
+G+ + +L + + + + + + E KIQ+ +N + + +E K ++ E
Sbjct: 759 MGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKE 818
Query: 5201 SVI-----------SVQKLLLDCQ-DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTA 5248
+ S+ L CQ ++ N L + K ++ + S L S P D
Sbjct: 819 EWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPK-IEMARASCSALMSQ--PSAPDFV 875
Query: 5249 SRIDELFQKRSSVLTQV---------NQLKTSM-QSVLQEWK-IYDQLYDEVNMMTIRFW 5297
R + F R + + N+LK + L+ K + D L D N +
Sbjct: 876 QRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQV--- 932
Query: 5298 YCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIE 5356
S V+ L + ++ ++L + E+ + + KL E L K + P V ++ +
Sbjct: 933 -----SLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYK 987
Query: 5357 EKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSN--------AHGEAAARLKQQEAKF 5408
++ + +W ++ ++ L + + +A+ G +KQQ A+
Sbjct: 988 QEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQG 1047
Query: 5409 ------QQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAES 5462
+QL S N + E + +L+++KE++ +++ A ++ + V RL +
Sbjct: 1048 DDAGLQRQLDQCSAFVNEI-ETIESSLKNMKEIETNLRSGPVAGIK-TWVQTRL---GDY 1102
Query: 5463 STHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDR 5522
T L L + +K L ++ E L KD E + + EEE L+R
Sbjct: 1103 QTQ------LEKLSKEIATQKSRLSESQEKAANLK--KDLA---EMQEWMTQAEEEYLER 1151
Query: 5523 LHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ--NMNRQWIRATA 5580
E ++P+ + V + D+ EV +K+ ++ + + + ++
Sbjct: 1152 --DFEYKSPEELESAVEEMKRAKEDVLQ-KEVRVKILKDNIKLLAAKVPSGGQELTSELN 1208
Query: 5581 TALER----CSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKM 5636
LE C+ ++G + ++ C WI+LL ++ L+ N+L E +M
Sbjct: 1209 VVLENYQLLCNRIRGKCHTLEEVWSC--WIELLHYLD--LETTWLNTLEE--------RM 1256
Query: 5637 LEAEVSINQTIADSYVTQSLQLL------DTTEIENRPEFITEFSKLTDRWQNAVQGVRQ 5690
EV +T A + +SL+ + + T+I + + + L D ++
Sbjct: 1257 KSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNS 1316
Query: 5691 RKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQ-----ERFSLYQTRSL-IHEL 5744
R D+ L Q S+E + L +T +L ++ ++ + Y T + ++
Sbjct: 1317 RYEDLSHLAESKQ---ISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQV 1373
Query: 5745 KNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQ 5804
+ Q + LTLE + + + L + ES R D + +++ +
Sbjct: 1374 PQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQL 1433
Query: 5805 FQSTVETWDQ---CEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASW 5861
FQ + C++ + +K+ L VL + DP + + + +L ++L+
Sbjct: 1434 FQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDP-----DVIQTHLDKCMKLYKTLSEV 1488
Query: 5862 TQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVV 5921
++ + + + ++ + EQ+ L + DL +V KQ++E
Sbjct: 1489 KLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARK 1548
Query: 5922 FNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSE---NKLQLKQMGD 5978
++ L WL E +++Q + + E ++ L + N+ + K L + +
Sbjct: 1549 MKKEAASLSEWLSATETELVQKS--TSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE 1606
Query: 5979 QLIKASNKSRAAE--IDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRT 6036
N +E ++++L +N W + L ++ D N++++ T
Sbjct: 1607 SSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHIST 1666
Query: 6037 WLARIESELSKPVVYDVCDDQEIQKRLAEQQD 6068
WL + E+ L + +EI KRL + D
Sbjct: 1667 WLYQAEALLDEIEKKPTSKQEEIVKRLVSELD 1698
Score = 78.6 bits (192), Expect = 2e-13
Identities = 241/1269 (18%), Positives = 482/1269 (37%), Gaps = 181/1269 (14%)
Query: 5182 LNNWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELK--QSYL--TL 5236
L+++ A EE L L E Q + D +++++Q A + EL QS + L
Sbjct: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
Query: 5237 ESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYD--EVNMMTI 5294
++G + + T S +E + L ++S+ ++ +++D L + + + +
Sbjct: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL 430
Query: 5295 RFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAE- 5353
W + + + L V++LQ L +E +S + E Q + L + V E
Sbjct: 431 SAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDEN 490
Query: 5354 -------IIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLW----------KAYSNAHGE 5396
I+E++ Q +RWT V + ++ + Q + LW KA+ E
Sbjct: 491 SGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEE 550
Query: 5397 AAARLKQQEAKFQQLANISMSGNNLA------EILPPALQDIKELQHDVQKTKEAFLQNS 5450
A ++ Q + F+ +S+S LA E+ L + E+ DV + L NS
Sbjct: 551 ALNKV--QTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQ----LLDNS 604
Query: 5451 SVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLK 5510
++ +E T QR L + L +N+ +++ + + L
Sbjct: 605 KASKKINSDSEELT-----------QRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLL 653
Query: 5511 GLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQN 5570
+ E+ + + +QE P + + DIE + D L N
Sbjct: 654 ETVRVREQAITKKSKQELPPPPPPKKRQIHV-----DIEAKKKF-------DAISAELLN 701
Query: 5571 MNRQWIRATATA-LERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLE 5629
+W A T ++ ++Q +K L EK E+ E + D N ++L
Sbjct: 702 WILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEK-----EQRERIPRADELNQTGQILV 756
Query: 5630 QQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR 5689
+Q + L T EI+N E K++ W+N Q +
Sbjct: 757 EQ----------------------MGKEGLPTEEIKNVLE------KVSSEWKNVSQHLE 788
Query: 5690 ------QRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTR-SLIH 5742
Q + D++ +Q + ++ ++ TS + R SL + S
Sbjct: 789 DLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTS-----ISESSRQSLPSLKDSCQR 843
Query: 5743 ELKNK-EIH--FQRRRTTCALTLEAGEKLLLTTDLKTK--ESVGRRISQLQDSWKDMEPQ 5797
EL N +H + R +C+ + D + +S R +Q++ +D +
Sbjct: 844 ELTNLLGLHPKIEMARASCSALMSQPS----APDFVQRGFDSFLGRYQAVQEAVEDRQQH 899
Query: 5798 LAEMIK--QFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE 5855
L +K + +ET + + + +++ QV D L ++ + L +K L + LE
Sbjct: 900 LENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLND-LAKVEKALQEKKTLDEILE 958
Query: 5856 QSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDR 5915
+ + +E + ++ ++ H VE + K++ + + +W L + V+ +E+
Sbjct: 959 NQKPALHKLAEETKALEKNV--HPDVEKLY--KQEFDDVQGKWNKLKVLVSKDLHLLEEI 1014
Query: 5916 LNTWVVFNEKNKELCAWL-----VQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENK 5970
T F + + W+ M+ + Q D ++ +++ + EI +
Sbjct: 1015 ALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA-FVNEIETIESSL 1073
Query: 5971 LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKN 6030
+K++ L + +L + + L I ++ +L E+ L K+
Sbjct: 1074 KNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKD 1133
Query: 6031 MSNLRTWLARIESE-LSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDV 6089
++ ++ W+ + E E L + Y +E++ + E + + D+ Q V+ + + +
Sbjct: 1134 LAEMQEWMTQAEEEYLERDFEYK--SPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKL 1191
Query: 6090 LLHDSDACANE--TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSR 6147
L + E +E + + + + L R R C +EE W W + L
Sbjct: 1192 LAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHT-------LEEVWSCWIELLHYLDL 1244
Query: 6148 FEDWLKSAERTAACPNSSEVL---YTSAKEELKRFEAFQRQIHERLTQLELINKQ----- 6199
WL + E S+EVL + E L+ E+ R + TQ+ + +
Sbjct: 1245 ETTWLNTLEERM---KSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGG 1301
Query: 6200 -YRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESIL 6258
+ E SR + + H + +L++++ VLR +E G
Sbjct: 1302 ILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQL-QVLRETDQMLQVLQESLG------ 1354
Query: 6259 VWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLD 6318
E+D QLT DA ++ Q EI+ + +++L + +S+PL
Sbjct: 1355 ----ELDKQLTTY-LTDRIDAFQVPQEAQKIQAEISAHELTLEEL-----RRNMRSQPLT 1404
Query: 6319 AVLIE-----DELEELHRYCQEV------FGRVSRFHRRLTSCTPGLEDEK-EASENETD 6366
+ +++ L R +EV F + + F +R+ C L+ K E +
Sbjct: 1405 SPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVK 1464
Query: 6367 MEDPREIQT 6375
DP IQT
Sbjct: 1465 DVDPDVIQT 1473
Score = 73.9 bits (180), Expect = 5e-12
Identities = 189/945 (20%), Positives = 364/945 (38%), Gaps = 150/945 (15%)
Query: 5502 FGVRLESLKGLIMHEEENL---DRLHQQEKENPDSFLNH---VLALTAQSPDIEHL---- 5551
+ + LE + ++ E+ D + +E D F H ++ LTA + +
Sbjct: 314 YQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAG 373
Query: 5552 NEVSLKLPLSDVAVKTLQN----MNRQWIRATATALERCSELQGI--GLNEKFLYCCEKW 5605
N++ + LSD +Q +N +W +++R S L + L +K L W
Sbjct: 374 NQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAW 433
Query: 5606 IQLLE----KIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
+ L E K+E D SL +LLE+ K+ L++++ Q +S +T + ++D
Sbjct: 434 LTLTEERIQKMETCPLDDDVKSLQKLLEEHKS---LQSDLEAEQVKVNS-LTHMVVIVDE 489
Query: 5662 TEIENRPEFITE-FSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS 5720
E+ + + KL +RW + +R + + WQ+ L +LT+
Sbjct: 490 NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549
Query: 5721 HLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESV 5780
L+ V QT + + KE+ RR A+ E E T D ++ +
Sbjct: 550 EALNKV---------QTSNFKDQ---KELSVSVRRL--AILKEDMEMKRQTLDQLSE--I 593
Query: 5781 GRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPEL 5840
G+ + QL D+ K + ++ + + WD
Sbjct: 594 GQDVGQLLDNSKASK----KINSDSEELTQRWDS-------------------------- 623
Query: 5841 HEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWED 5900
L++ LE S TQ + +L + + + L+E V V ++ I +Q +
Sbjct: 624 ---------LVQRLEDSSNQVTQAVAKLGM--SQIPQKDLLETVRVREQAITKKSKQ--E 670
Query: 5901 LCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADIS----------IEE 5950
L +K++I + F+ + EL W+++ + + QT +I +++
Sbjct: 671 LPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAI-QTTEIKEYMKMQDTSEMKK 729
Query: 5951 MIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSR--AAEIDDKLNKINDRW----Q 6004
++ L+K+ E I E L Q G L++ K EI + L K++ W Q
Sbjct: 730 KLKALEKEQRERIPRADE----LNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQ 785
Query: 6005 HLFDVIGSRVKKLKETFAFIQQLDKNMSNLRT---WLARIE----SELSKPVVYDVCDDQ 6057
HL D + +++ ++ A+ +QLD+ ++T W+ S S P + D C
Sbjct: 786 HLED-LERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSC--- 841
Query: 6058 EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRW 6117
Q+ L L IE A C L+ A D +Q+ S R+
Sbjct: 842 --QRELTNLLGLHPKIEMARAS-------CSALMSQPSAP------DFVQRGFDSFLGRY 886
Query: 6118 RNICAMSMERRMKIEETWR--LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
+ + +R+ +E + +L+ +D L +E A S VL AK E
Sbjct: 887 QAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQV--SLNVLNDLAKVE 944
Query: 6176 --LKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRV 6233
L+ + + + L + ++ + L + D KQ + +W+ L+ V
Sbjct: 945 KALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLV 1004
Query: 6234 TAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDA--DDKMRQLNGFQQ 6291
+ L L FE I W+ + L + DA ++ Q + F
Sbjct: 1005 SKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVN 1064
Query: 6292 EITLNTNKIDQLIVFGEQLIQKSEPLDAV--LIEDELEELHRYCQEVFGRVSRFHRRLTS 6349
EI + + + L +S P+ + ++ L + +++ ++ RL+
Sbjct: 1065 EIETIESSLKNMKEIETNL--RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLS- 1121
Query: 6350 CTPGLEDEKEASENETDMEDPREIQTDSWRKRGESE-EPSSPQSL 6393
E +++A+ + D+ + +E T + + E + E SP+ L
Sbjct: 1122 -----ESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEEL 1161
Score = 73.2 bits (178), Expect = 9e-12
Identities = 311/1743 (17%), Positives = 673/1743 (38%), Gaps = 282/1743 (16%)
Query: 2171 LQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK--NPSFSEEPWLEIKH 2228
L+H + + L I K L +D+ L + KS YL + + + E++
Sbjct: 211 LEHAFSKAQTYLGIEK--LLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVET 268
Query: 2229 LHESLLQQLQDSVQNLDGHV--REHDSYQV----CVTDLNTTLDNFSKEFVSFSDKPVDQ 2282
L ++ ++ N+ EH+S + VT+++ LD++ Q
Sbjct: 269 LPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSY-------------Q 315
Query: 2283 IAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDL 2342
IA+EE L L E+ QD ++ V++ +KD + + +L
Sbjct: 316 IALEEVLTWLLSAEDTFQEQDD-------ISDDVEE---------VKDQFATHEAFMMEL 359
Query: 2343 ENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEED 2402
+S ++ I + S E++ E Q + + E+ VE ++
Sbjct: 360 TAHQSSVGSVLQAGNQLITQGTLSDEEEF-------EIQEQMTLLNARWEALRVESMDRQ 412
Query: 2403 WEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLY 2462
++ D +E+ KQL Q S T E ++ +++ PL+ D + LEE + L
Sbjct: 413 SRLH-DVLMEL-QKKQLQ---QLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQ 467
Query: 2463 TQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVL 2522
+ LEA++ + L + +G + Q L A+ + + ++ +
Sbjct: 468 SDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527
Query: 2523 RDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWE 2582
+ L + +KA LT+KE + + + + D+ K+ S+ + ++++K +
Sbjct: 528 NILWQELLEEQCLLKAWLTEKEE-ALNKVQTSNFKDQ-KELSVSVRRLAILKEDMEMKRQ 585
Query: 2583 NL-------------------SNHVTDMDKKLL---ESQIKQLEHGWEQVEQQIQKKYSQ 2620
L S + ++L +S +++LE QV Q + K
Sbjct: 586 TLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMS 645
Query: 2621 QVVEYDEFTTLMNKVQDTEISLQQQQQ------------HLQLRLKSPEERAGNQSM--- 2665
Q+ + D T+ +V++ I+ + +Q+ H+ + K + + +
Sbjct: 646 QIPQKDLLETV--RVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI 703
Query: 2666 IALTTDLQATK-HGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
+ T +Q T+ + ++ +E++ K EKE++ + L + + L + +
Sbjct: 704 LKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQIL--VEQMGK 761
Query: 2725 NQIKKCDIRNKMKETILWAKNL---LGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+ +I+N +++ KN+ L +L I L +DI + ++ I +++
Sbjct: 762 EGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQ-LQEDINAYFKQLDELEKVIKTKEEW 820
Query: 2782 VE--SLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNF 2839
V+ S++E + +PSL +L N L L + +M + Q + F
Sbjct: 821 VKHTSISESSRQSLPSLKDSCQRELTNLL-GLHPKIEMARASCSALMSQPSAPDFVQRGF 879
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELT 2899
+ + ++Q VQE+ + R + E + + H LE + K L+++ + Q
Sbjct: 880 DSFLGRYQ-AVQEA---VEDRQQHLENELKGQPGHAYLE-TLKTLKDVLNDSENKAQVSL 934
Query: 2900 NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEV-EHKIKFCRQFHEKTSALQEE 2958
N+ +L E+ E + T +E+ E++ + E+T AL++
Sbjct: 935 NVLNDLAKVEKALQE-----------------KKTLDEILENQKPALHKLAEETKALEKN 977
Query: 2959 ADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVF----------DYI 3008
++ +V K K+E +++ + +K + + L L + +
Sbjct: 978 ----------VHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTV 1027
Query: 3009 GLNWDFSQLDQLQTQVFEK--EKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKK-- 3064
W D L Q + + L+ ++ Q F E ++ L M+ I+ ++
Sbjct: 1028 IEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGP 1087
Query: 3065 ----MTEVVLKAPDSSPESRRLNAQI------LSQRIEKAKCLCDEIIKKLNENKTFDDS 3114
T V + D + +L+ +I LS+ EKA L ++ + ++
Sbjct: 1088 VAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEE 1147
Query: 3115 FKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ 3174
+ E++ + K + EE + + ++ ++ KE+ K +D ++ + +L
Sbjct: 1148 YLERD-FEYK-SPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTS 1205
Query: 3175 PLLINLEIKHI--QNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLRE 3232
L + LE + + C E+VW+ C I+ + ++ + ++ + +E +++
Sbjct: 1206 ELNVVLENYQLLCNRIRGKCHTL-EEVWS--CWIELLHYLDLE----TTWLNTLEERMKS 1258
Query: 3233 FEDLQMQ---LNTSIDLRTNVLNDAYENLTRYKEAVTRAVES-------ITSLEAIIIPY 3282
E L + +N +++ +VL +N T+ +E ++ LEA Y
Sbjct: 1259 TEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRY 1318
Query: 3283 RVDVGNPEESLEMPLRKQ-EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNS 3341
D+ + ES ++ L KQ + L T +Q L E LG E QL L + +
Sbjct: 1319 E-DLSHLAESKQISLEKQLQVLRETDQMLQVLQESLG-----ELDKQLTTYLTDRIDAFQ 1372
Query: 3342 AMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREA---LE 3398
+EA K Q + L + R M T+ G M L RE +
Sbjct: 1373 VPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQ 1432
Query: 3399 RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAK 3458
++ ++ K L ++ L +L ++ + D ++ +K + L +
Sbjct: 1433 LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPD------VIQTHLDKCMKLYKTLS 1486
Query: 3459 EWEMWCEELKQEWKFV---------------------------------SEEIEREAIIL 3485
E ++ E + + + + +++ER + +
Sbjct: 1487 EVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLA 1546
Query: 3486 DNLQEELPEISKTKEA--------ATTEELSELLDCLCQYGENV----EKQQLLLTLLLQ 3533
+++E +S+ A +T+E L LD + +NV EK++ L + +
Sbjct: 1547 RKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE 1606
Query: 3534 RIRSIQNVPESSG-------AVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERH 3586
++QN+ E S V + T ++ CN L+ Q E+ +
Sbjct: 1607 SSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNH-QNQLEIFDGNVAHIS 1665
Query: 3587 SFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKY 3646
++ + AL + ++ TS ++ E + L S L L EN+ ++ I
Sbjct: 1666 TWLYQAEALLDEIEKKPTS----------KQEEIVKRLVSELDDANLQVENVRDQALILM 1715
Query: 3647 SEMYTIVPAEIESQVEECRKALEDIDEKISNE--VLKSSPSYAMRRKIEEINNGL----- 3699
+ + +E ++ E + E + + I + ++ P Y E G+
Sbjct: 1716 NARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDL 1775
Query: 3700 ----HNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEW 3755
+++E ML+ K++E + E DE K++E +++++++++ +
Sbjct: 1776 EKLENDIENMLKFVEKHLESSDE------DE------KMDEESAQIEEVLQRGEEMLHQP 1823
Query: 3756 MDN 3758
M++
Sbjct: 1824 MED 1826
Score = 68.6 bits (166), Expect = 2e-10
Identities = 347/1937 (17%), Positives = 751/1937 (38%), Gaps = 301/1937 (15%)
Query: 4481 ILPSVTMYNFRYPTTE-ELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLT 4539
I +T+ N R+ E ++L D+ E Q Q+ A++ L ++ + T
Sbjct: 390 IQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL---SAWLTLTEERIQKMET 446
Query: 4540 --LSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPG 4597
L + S++++LE + + D +QV +L + + D+ G
Sbjct: 447 CPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH-----MVVIVDENS---------G 492
Query: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSK---- 4653
E+ +LE D LQ E AVCR + +NR EI L+ +L++ +
Sbjct: 493 ESATAILE--DQLQKLGERW--TAVCRWTEER----WNRL--QEINILWQELLEEQCLLK 542
Query: 4654 ---TSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVY 4710
T +++LN++ + +Q EL + R+A L+++ E L E+
Sbjct: 543 AWLTEKEEALNKVQTSNFKDQK--------ELSVSVRRLAILKEDMEMKRQTLDQLSEIG 594
Query: 4711 K-LEDVLDSMWGM--LRARYTELSSPF--VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
+ + +LD+ + + EL+ + + + +D+ Q + K+G ++ L +
Sbjct: 595 QDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLE 654
Query: 4766 T----------KSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQ 4815
T KSK L K + A SA++L +L+ + A Q
Sbjct: 655 TVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKT---AIQ 711
Query: 4816 VTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLV 4875
TE+K MK+Q E + +LEK+ +P + +T + LV
Sbjct: 712 TTEIKEY--------MKMQDT----SEMKKKLKALEKEQR---ERIPRADELNQTGQILV 756
Query: 4876 ERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE 4935
E++ GK+ + E++ + K+ +W ++++ ++ +
Sbjct: 757 EQM-----------------------GKE---GLPTEEIKNVLEKVSSEWKNVSQHLE-D 789
Query: 4936 LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWK--EQSLNVSQDL-DTIRSNINNFF 4992
L R L + + +Y + D+L K +++ + + + E S L D+ + + N
Sbjct: 790 LERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLL 849
Query: 4993 EFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLH 5052
+++ + +A++S + + ++ F ++ + + D Q+ L
Sbjct: 850 GLHPKIEMARASCSALMS--------QPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLE 901
Query: 5053 QLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQ 5112
+++ P A E + + +V + DS + + V + L K ++ E
Sbjct: 902 N-ELKGQPGH-AYLETLKTLKDVLN-----DSENKAQVSLNVLNDLAKVEKALQEKKTLD 954
Query: 5113 WIVDFVNQSLLQLSTCDVESKRYERTE-------FAEHLGEMNRQWHRVHGMLNRKIQHL 5165
I++ +L +L+ E+K E+ + + ++ +W+++ ++++ + L
Sbjct: 955 EILENQKPALHKLAE---ETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLL 1011
Query: 5166 EQLLESITESENKIQILNNWLEAQEERLKTLQKPESV-ISVQKLLLDCQDIENQLAIKSK 5224
E++ ++ E ++ W++ ++ L Q + +Q+ L C N++
Sbjct: 1012 EEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES 1071
Query: 5225 ALDELKQSYLTLESGAVP--------LLEDTASRIDELFQKRSSVLTQVNQLKTSMQSV- 5275
+L +K+ L SG V L D +++++L ++ + TQ ++L S +
Sbjct: 1072 SLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKE---IATQKSRLSESQEKAA 1128
Query: 5276 --------LQEWKIY-DQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
+QEW ++ Y E + E+ P E L VE ++ +++
Sbjct: 1129 NLKKDLAEMQEWMTQAEEEYLERDF---------EYKSP-----EELESAVEEMKRAKED 1174
Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQ-KAQSLLQ 5385
E + L++ I L PS + + + + + Q + ++++ K +L +
Sbjct: 1175 VLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENY----QLLCNRIRGKCHTLEE 1230
Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEA 5445
+W + E L + L S E+LP + E ++
Sbjct: 1231 VWSCWI----ELLHYLDLETTWLNTLEERMKS----TEVLPEKTDAVNEALESLESV--- 1279
Query: 5446 FLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVR 5505
L PA++ T + G +L L+ ++ K F S+++D
Sbjct: 1280 ----------LRHPADNRTQIRELG--QTLIDGGILDDIISEKLEAFN---SRYEDLSHL 1324
Query: 5506 LESL-----KGL-IMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDI-EHLNEVSLKL 5558
ES K L ++ E + + ++ Q+ D L L + + + ++ ++
Sbjct: 1325 AESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384
Query: 5559 PLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
++ ++ L+ NM Q + + + R + L K K+ QL +K
Sbjct: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDV-LQRKLREVSTKF-QLFQK------ 1436
Query: 5618 VDVANSLPELLEQQKTYKMLEAEV------SINQTIADSYVTQSLQLLDTTEIENRPEFI 5671
AN +L+ ++ ++AE+ ++ + +++ + ++L T E
Sbjct: 1437 --PANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLS-----EVK 1489
Query: 5672 TEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQER 5731
E + ++ VQ +Q+ + G+ Q +L +T+ L R
Sbjct: 1490 LEVETVIKTGRHIVQ--KQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLAR 1547
Query: 5732 FSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLL----LTTDLKTKESVGRRISQ- 5786
+ SL L E ++ T+ L + ++ + DL+ +++ I++
Sbjct: 1548 KMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITES 1607
Query: 5787 ---LQDSWKDMEPQLAE---MIKQFQSTVETW--DQCEKKIKELKSRLQVLKA------- 5831
LQ+ + EP L E ++ S V TW D C + +++L++
Sbjct: 1608 SAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNH-QNQLEIFDGNVAHIST 1666
Query: 5832 ---QSEDPLPELHED-LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVL 5887
Q+E L E+ + ++E++K L L ++ ++ L ++
Sbjct: 1667 WLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELV 1726
Query: 5888 KEQIEHLHRQWEDLCLRVAIRKQEI-EDRLNTWVVFNEKNKELCAWLVQMENKVLQTADI 5946
+ ++ L+R +E + + K I ++ L +V E + + L+ +
Sbjct: 1727 EPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTE------TFETGVPFSDLEKLEN 1780
Query: 5947 SIEEMIEKLQK--DCMEEINLFSENKLQLK---QMGDQLIKASNKSRAAEIDDKLNKIND 6001
IE M++ ++K + +E E Q++ Q G++++ + D+K KI
Sbjct: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPME------DNKKEKI-- 1832
Query: 6002 RWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQK 6061
R Q L ++ +R K+K +++ + S +R+ L + + + DD E+
Sbjct: 1833 RLQLL--LLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSL 1890
Query: 6062 RLAEQQDLQRDIEQHSAGVESVFNICDVL--LHDSDACANETECD-----------SIQQ 6108
+ E E S +S+ NI D L L + A +E + D I+
Sbjct: 1891 NVPELNTAI--YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRD 1948
Query: 6109 TTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER--TAACPNSSE 6166
T L+ +W I M +R+ + W++F D + W+ AE C
Sbjct: 1949 TLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGS 2008
Query: 6167 VLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRW 6226
+ A+ + E I +N+ + ++ S LK+ + NQRW
Sbjct: 2009 LDLEKARIHQQELEV---GISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRW 2065
Query: 6227 DNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL 6286
D + V RL+ + Q ++ + I+ WLT+ + + + S ++ + +++L
Sbjct: 2066 DAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAM---QKRSTTELGENLQEL 2122
Query: 6287 NGFQQEITLNTNKIDQL 6303
QE+ ++ K+ L
Sbjct: 2123 RDLTQEMEVHAEKLKWL 2139
Score = 49.7 bits (117), Expect = 1e-04
Identities = 108/631 (17%), Positives = 244/631 (38%), Gaps = 111/631 (17%)
Query: 5623 SLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENR-------PEFITEFS 5675
SL E+L QQ T + ++ + +++ + T E P +TE
Sbjct: 249 SLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVD 308
Query: 5676 KLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLY 5735
D +Q A++ V + S E+ F+ D S + VK Q
Sbjct: 309 MDLDSYQIALEEVLT--------------WLLSAEDTFQEQDDISDDVEEVKDQ------ 348
Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKES--VGRRISQLQDSWKD 5793
HE E+ +++ L+AG +L+ L +E + +++ L W+
Sbjct: 349 ---FATHEAFMMEL--TAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
Query: 5794 MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHEDLHNEKELI 5851
+ ++ M +Q + + +K++++L + L + + Q + P L +D+ + ++L+
Sbjct: 404 L--RVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCP-LDDDVKSLQKLL 460
Query: 5852 KELEQSLASWTQNLKELQTMKADLTRHVLVED-------VMVLKEQIEHLHRQWEDLCLR 5904
+E +SL S +L+ Q LT V++ D +L++Q++ L +W +C
Sbjct: 461 EE-HKSLQS---DLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRW 516
Query: 5905 VAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCM- 5960
R +++ W E+ L AWL + E NKV + +E+ +++ +
Sbjct: 517 TEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAIL 576
Query: 5961 -EEINLFSENKLQLKQMGDQLIKASNKSRAA-EIDDKLNKINDRWQHLFDVIGSRVKKLK 6018
E++ + + QL ++G + + + S+A+ +I+ ++ RW L + ++
Sbjct: 577 KEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVT 636
Query: 6019 ETFAFI-----------------------------------------------QQLDKNM 6031
+ A + ++ D
Sbjct: 637 QAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAIS 696
Query: 6032 SNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
+ L W+ + ++ + + + Q+ + + + L+++ + + + +L+
Sbjct: 697 AELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
Query: 6092 HDSDACANETECDSIQQTTRSLDRRWRNIC--AMSMERRMKIEETWRLWQKFLDDYSRF- 6148
TE I+ + W+N+ +ER+++++E + K LD+ +
Sbjct: 757 EQMGKEGLPTE--EIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVI 814
Query: 6149 ---EDWLKSAERTAACPNSSEVLYTSAKEEL 6176
E+W+K + + S L S + EL
Sbjct: 815 KTKEEWVKHTSISESSRQSLPSLKDSCQREL 845
Score = 44.7 bits (104), Expect = 0.003
Identities = 237/1278 (18%), Positives = 484/1278 (37%), Gaps = 270/1278 (21%)
Query: 738 DVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQN 797
D+EKL +E + L+ D D M+E + + +E++ R E+ML +++
Sbjct: 1774 DLEKLENDIENMLKFVEKHLESSDEDEKMDE-------ESAQIEEVLQRGEEMLHQPMED 1826
Query: 798 ISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKEL 857
KEK+++ ++ L + + + KM + +
Sbjct: 1827 --------------------NKKEKIRLQLLLLHTRYNKIKAIPIQ---QRKMGQLASGI 1863
Query: 858 ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
S ++ P + + + + L+ + L+ V EL + ED E+
Sbjct: 1864 RSSLL-----------PTDYLVEINKILLCMDDVELSLN---VPELNTAIYEDFSFQ-ED 1908
Query: 918 KSRDVCAKWESLHHELS-LYVQQLKIDIEKG-----KLSDNILKLEKQINKEKKLI--RR 969
+++ + + L +++ ++ +Q + +E ++ D + +L + ++ ++ R+
Sbjct: 1909 SLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRK 1968
Query: 970 GRTKGLIKEHEACFSEEGCLYQ-LNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
G ++E + L Q + E+L + C P E R+ ++Q++E
Sbjct: 1969 GCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCA--PGGSLDLEKARI---HQQELEV 2023
Query: 1029 LLKCASEIHMTLQPTAGGT----SKNEGTITTSENRGGDPHSEAPFAK-SDNQPSTEKAM 1083
+ L T G S+ +G+ + G + +A A+ D QP +
Sbjct: 2024 GISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGES 2083
Query: 1084 EPTMKF--SLASVLRPLQE-ESIMEKDYSASINSLLERYDTYRDILEHH------LQNNK 1134
+ MK+ L ++ L + E M+K + + L+ +E H L +
Sbjct: 2084 KQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTE 2143
Query: 1135 FRITSDFS---SEEDRSSSCLQAKLTDLQVIKNETDARWKEF-----EIISLKLENHVND 1186
+ SD S E D+ S L+ I E KE + ++ H N
Sbjct: 2144 LEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNV 2203
Query: 1187 IKKPFVIKERDTLKERERELQMTLNTRMESLETALR----LVLPVEKASLLLCGSDLPLH 1242
K V D + R ++++ ++ T L L+ + K++++ G ++
Sbjct: 2204 QKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEIN 2263
Query: 1243 KMAIQGFHLIDAD------------RIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELH 1290
K + + AD + Q+L+N S + I +LE N H
Sbjct: 2264 K-TVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQH 2322
Query: 1291 PFDLHAMQ--NIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348
+L Q ++I+ + +HR + +E+ ++ E L L+ A+ +P+T S
Sbjct: 2323 GVELRQQQLEDMIID---SLQWDDHR-EETEELMRKYEARLYILQQAR--RDPLTK-QIS 2375
Query: 1349 DTQV-------------AQENTLTVKNKE---GEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
D Q+ A +N L +E + +K+ ++L L S D +
Sbjct: 2376 DNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQ 2435
Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKN--------NELLKNIQ 1444
+ + S + E +QE T N L++A +N EL + +Q
Sbjct: 2436 NALEAEWRTV--QASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQ 2493
Query: 1445 DVQSQI--------SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPH 1496
D+Q++I S G + V A+ + +++ + L LD+ + L+ + S+
Sbjct: 2494 DIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATM-LQHRLDDMNQRWNDLKAKSASIRA 2552
Query: 1497 FKDGREKTVNQQCQNT--VVLWENTKALVTECLEQC---GRVLELLKQYQNFKSILTTLI 1551
+ + N+ + ++ W N K E +Q G V L QY + K++ L
Sbjct: 2553 HLEASAEKWNRLLMSLEELIKWLNMKD--EELKKQMPIGGDVPALQLQYDHCKALRRELK 2610
Query: 1552 QKEESVIS-------------LQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVC 1598
+KE SV++ ++A + NL+ + E+ EE + ++
Sbjct: 2611 EKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKT---ELTPEE---------RAQKIA 2658
Query: 1599 KNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVI 1658
K ++ K+++ + ++W +N T ++ + + +AL +KL +L+ +
Sbjct: 2659 KAMR---------------KQSSEVKEKWESLNAVTSNWQKQVDKAL---EKLRDLQGAM 2700
Query: 1659 DEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQ-----SSEI- 1712
D+ + + + + L + LQ H +K F +A I F ++ SS++
Sbjct: 2701 DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLS 2760
Query: 1713 PLEL-----------------QVMESSILNKMEHVQKCLT--GESNCHALSGST------ 1747
PL+L ++++ S+ ++++ +Q+ G S+ H LS S
Sbjct: 2761 PLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQR 2820
Query: 1748 -------------------------AELRE---DLDQAKTQIGMTESLLKALSPS---DS 1776
EL + DL+ + T ++ L + D
Sbjct: 2821 SISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDL 2880
Query: 1777 LEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHF 1836
LE+ T E +Q L Q ++ + + I CLT L++ ++ DL N V
Sbjct: 2881 LELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHK---DLVNVPLCV----- 2932
Query: 1837 SKLLNDQCKNFNDWFSNI 1854
D C N W N+
Sbjct: 2933 -----DMCLN---WLLNV 2942
Score = 43.9 bits (102), Expect = 0.006
Identities = 38/179 (21%), Positives = 83/179 (46%), Gaps = 5/179 (2%)
Query: 6577 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSV 6636
+Q + D++ +T W+ TEAE ++ P + + R+ + QE+ +++ ++
Sbjct: 1979 RQFHCDLNDLTQWI--TEAEELLVDTCAPGGSLDLEKARIHQ-QELEVGISSHQPSFAAL 2035
Query: 6637 NVSSKEFLQTESP-ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQN 6695
N + +Q S + + L+ +L L+ W+A V + L+ Q +
Sbjct: 2036 NRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDE 2095
Query: 6696 LLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLEKELVERQPQVDMLQEISNSL 6753
++ WL A++ QK T+ + + L + +E+ + EK + +++ML + S SL
Sbjct: 2096 IICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSL 2154
Score = 37.7 bits (86), Expect = 0.40
Identities = 51/256 (19%), Positives = 107/256 (41%), Gaps = 22/256 (8%)
Query: 6538 QQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTE 6594
+Q+ G+ EQ + + + AQ K +++ Q ++ + ++++ WL TE
Sbjct: 1505 KQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564
Query: 6595 AELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTEL 6654
EL ++ + + +++ + + +LK + KA + ++ SS L
Sbjct: 1565 TEL--VQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPIL 1622
Query: 6655 QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTD 6714
+ RL L+ W + + W L Q + F ++ WL A +A + +
Sbjct: 1623 EERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQA-----EALLDE 1677
Query: 6715 PKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEK 6774
+ P + E + +L EL + QV+ +++ +L+ G E ++E
Sbjct: 1678 IEKKPTSKQE--EIVKRLVSELDDANLQVENVRD-QALILMNARGSSSRE------LVEP 1728
Query: 6775 KLKQLR---EQVSQDL 6787
KL +L E+VSQ +
Sbjct: 1729 KLAELNRNFEKVSQHI 1744
Score = 33.5 bits (75), Expect = 7.5
Identities = 28/149 (18%), Positives = 58/149 (38%), Gaps = 3/149 (2%)
Query: 6644 LQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6703
L+ PE+ +++ L QL+ W+ +G +++ + + FH +L W+ A
Sbjct: 1936 LEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEA 1995
Query: 6704 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6763
+ D L + R +LE + QP L + ++ K D
Sbjct: 1996 EELLVDTCAPGGSLD---LEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGS 2052
Query: 6764 EAEEKVHVIEKKLKQLREQVSQDLMALQG 6792
+EK+ + ++ + +V L+G
Sbjct: 2053 FLKEKLAGLNQRWDAIVAEVKDRQPRLKG 2081
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 212 bits (539), Expect = 1e-53
Identities = 672/3714 (18%), Positives = 1448/3714 (38%), Gaps = 480/3714 (12%)
Query: 2856 LIIPRVETAATEAELKHHHVT--LEASQKELQEIDSGISTHLQ---ELTNIYEELNVFER 2910
L + R + ++ + + H V LE Q EL+ I + + L EE +
Sbjct: 1240 LDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQE 1299
Query: 2911 LFLEDQLKNLKIRTNRIQR----FIQNTCNEVEHKIKFCRQFHEKTSALQE--EADSIQR 2964
+ Q ++ ++ + ++ + F + N+ K+ C++F ++ S + + E +
Sbjct: 1300 MMKPGQAEDSRVLSEQLSQQTALFAEIERNQT--KLDQCQKFSQQYSTIVKDYELQLMTY 1357
Query: 2965 NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQ- 3023
+ +Q+ + G + + + D +T +++ L ++ L L TQ
Sbjct: 1358 KAFVESQQKSPGKRRRMLSSSDAITQ---------------EFMDLRTRYTALVTLTTQH 1402
Query: 3024 ---VFEKEKELEEKIKQLDTFEEEH-GKYQALLSKMRAIDLQIKKMTEVVLKAPDS-SPE 3078
+ + + LEE+ K ++ ++EH K + LL + + + KA S + E
Sbjct: 1403 VKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQG------KATSSETKE 1456
Query: 3079 SRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQ 3138
S + IL Q++ L +E+ K + ++ K +I K + ++K K +
Sbjct: 1457 STDIEKAILEQQV-----LSEELTTKKEQ---VSEAIKTSQIFLAKHGHKLSEKEKKQIS 1508
Query: 3139 NMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQ 3198
+ L+ K D + S + L Q++SQL E K +Q +++ C E
Sbjct: 1509 EQLNALN------KAYHDLCDGSANQLQQLQSQLAH----QTEQKTLQKQQNTCHQQLED 1558
Query: 3199 V--WAEMC-----------SIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSID 3245
+ W + + ++A++K + + D++ + F + + ++
Sbjct: 1559 LCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME 1618
Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELES 3305
L+ LT +E + +A E +L+ RV EE++ L+++ E
Sbjct: 1619 ENQTKLSP--RELTALREKLHQAKEQYEALQE---ETRVAQKELEEAVTSALQQETEKSK 1673
Query: 3306 TVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
+ + +K+ + S + QL L + + A E T+ Y+
Sbjct: 1674 AAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG--YMGV 1731
Query: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
+ K+++ ++ + +L Q + + L+ + A L+Q NL T EE L
Sbjct: 1732 NQAPEKLDKQCEMMKARHQELLSQQQNFI-LATQSAQAFLDQHG---HNL--TPEEQQML 1785
Query: 3421 RQILRLLRLRCTEN--DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEI 3478
+Q L L+ + + + LK V L ++ L+ KE+E W E ++E
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE-------- 1837
Query: 3479 EREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ---LLLTLLLQRI 3535
L+N+ K ++ E L LL + E+V + +T+ Q++
Sbjct: 1838 ------LENMH---------KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV 1882
Query: 3536 RSIQNVPESSGAVETVPAF--QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEII 3593
++N + + ++ ER L K + + + + H F
Sbjct: 1883 LDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSAD 1942
Query: 3594 ALKNFFQQTTTSFQNM----AFQDHPEKSEQF---EELQSILKKGKLTFENIMEKLRIKY 3646
+L+ + Q + + + D EQ ++LQ L + ++ E + + R
Sbjct: 1943 SLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--- 1999
Query: 3647 SEMYTIV--PAEIESQVEECRKALEDIDEKISNEVLKSSP--------SYAMRRKIEEIN 3696
++ I PA V+E ++ + +S + + S S +++ +E +
Sbjct: 2000 -DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
Query: 3697 NGLHNVEKMLQQKSKN------IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQ-DP 3749
+ VE+ L+ K + I++A K+ ++ S L V +E D
Sbjct: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
Query: 3750 GQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA 3809
A L Q+++Q+ + + + S L K + E + L + ++EN S +LA
Sbjct: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2178
Query: 3810 NPADYDSLRTLSHHASTVQ---MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQE 3866
+ D + ++H +Q + +ED ++ + L + +L + + +Q
Sbjct: 2179 SGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236
Query: 3867 LSNQVTALQQKIME---SLPQIQRMADD----VVAIESEVKSMEKRVSKIKTILLSKEIF 3919
L T LQ+ + E Q D+ V + +K E + +T + +KE+
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL- 2295
Query: 3920 DFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELR------------------LPQTGM 3961
E+ ++H + +L++ + EI L LP G
Sbjct: 2296 ----EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS 2351
Query: 3962 KPLPV--FQRTNQL------LQDIKL----LENVTQEQNELLKVVIKQTNEWDEEIENLK 4009
V + L + D+ L L V E+ E L+ ++ + E +E ++
Sbjct: 2352 SVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVL 2411
Query: 4010 QILNNYSAQF-SLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLH 4068
Q L + S++ MS + + Q E + L N K + + A +L +
Sbjct: 2412 QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2471
Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
+ QE E ++ + + E A +R+L S S+LA +
Sbjct: 2472 PN-SQEAENWKKIQEELNSRWERATEVTVARQRQLEE--SASHLACFQA----------- 2517
Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
AE + W ME++ G + + + + Q + +
Sbjct: 2518 ----AESQLRPWL--------MEKELMMGVLGPLSIDP--NMLNAQKQQVQFMLKEFEAR 2563
Query: 4189 EQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAEL 4248
Q E + N+ +G +L +S Q L+ + + E T+ L++ +Q+ +
Sbjct: 2564 RQQHE---QLNEAAQGILTGPGDVSLSTSQVQKELQS-INQKWVELTDKLNSRSSQIDQ- 2618
Query: 4249 ELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGAT 4308
A+ T ++ Q L +++ L+ ++ ++ E K Q L +
Sbjct: 2619 ---------AIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPEAVKQQ-LEETSEI 2667
Query: 4309 QHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEP-EHQEALQPVNLSELE 4367
+ + E L ++K + +++ +++ E++ +D+ L+ + P + E L ++ L+
Sbjct: 2668 RSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727
Query: 4368 SIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSAS 4427
+ + QF + D + + L+ K +Q K +AK Q +N+ Q+S +
Sbjct: 2728 AALASTQQFQQMFD-ELRTWLDDKQSQQA---KNCPISAKLERLQSQLQENEEFQKS-LN 2782
Query: 4428 NQASSPENDVPDS---ILS-PQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
+ S E V + +LS P G+ Q EL + + L + + S +
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWE-ELSKKTADRQSRLKDCMQ 2841
Query: 4484 SVTMYNFRY----PTTEELKTYTTQL----EDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
Y + P E+ K ++L + ++ E+S L+++ + E + + L E
Sbjct: 2842 KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE---VEKRRSLLE 2898
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK----GDLLK 4591
+ + + L + E E + G Q + T L+ K L ++ + K
Sbjct: 2899 ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFK 2958
Query: 4592 AMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIK 4651
+ E LE FD L + C +K+L+ R+ Q ++ L Q+
Sbjct: 2959 NIEKKVEGAKHQLEIFDAL--------GSQACSNKNLEK----LRAQQEVLQALEPQVDY 3006
Query: 4652 SKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYK 4711
+ Q + + S A QL L AE + + +R++ +++ K
Sbjct: 3007 LRNFTQGLVEDAPDGSDASQL---------LHQAEVAQQEFLEVKQRVNSGCVMMEN--K 3055
Query: 4712 LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVA 4771
LE + G R E+ S + D L GM IG++ +
Sbjct: 3056 LEGI-----GQFHCRVREMFSQL---ADLDDELDGMGA---IGRDT------------DS 3092
Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
LQ+QIE+ ++F K+ L I+A A+ L E + + + LE ++QCG
Sbjct: 3093 LQSQIEDVRLFLNKIHVLKLDIEASEAECRHML---EEEGTLDLLGLKRELEALNKQCGK 3149
Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETE----------ERLVERISFY 4881
+ + E+ + +E L + + EE E E + ++++ +
Sbjct: 3150 LTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADF 3209
Query: 4882 QQI-KRNIGGKHARLYQTLNEGKQLVASVS----CPELEGQIAKLEEQWLSLNKKIDHEL 4936
+ K + +L Q G+ L+ S LE + ++ +W +LNKK+ +
Sbjct: 3210 KMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRI 3269
Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
+LQ L H + + L WL ++ + K S + +++ I +
Sbjct: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQR 3325
Query: 4997 EVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
+D++ + + + G ++ E D + L E +WT L+++ Q++L +
Sbjct: 3326 LLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3385
Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
+ + + +++ E + ++ + V + ++ +++ + +HK +E D +
Sbjct: 3386 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA--KIQQQIIRHKA--LEEDIENHAT 3441
Query: 5116 DFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE- 5174
D V+Q++ + + E+ +E + + ++ + RK L+Q L +
Sbjct: 3442 D-VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLF 3500
Query: 5175 SENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYL 5234
E+++++LN WL E++L ++ V ++ +L Q ++ LA+ + ++ K
Sbjct: 3501 GEDEVEVLN-WLAEVEDKLSSV----FVKDFKQDVLHRQHADH-LALNEEIVNRKKNVDQ 3554
Query: 5235 TLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQL-------YD 5287
+++G L + T + + +K + T+ + + L+ + QL Y+
Sbjct: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
Query: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
E+ + S + E + + + L+ E + + EV L L
Sbjct: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL 3674
Query: 5348 CPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEA 5406
P A E +++ + ++++ V+ I ++ + + +Q + Y A A + + +
Sbjct: 3675 VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKR 3734
Query: 5407 KFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK----EAFLQNSSVLDRLPQPAES 5462
K L I + + LQ K D+ + K E F S + + ++
Sbjct: 3735 KLMALGPIRLEQDQTTA----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKT 3790
Query: 5463 STHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF----KDFGVRLESLKGLIMH--- 5515
+ + + L + + +++QF ++ +E + LI
Sbjct: 3791 VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPS 3850
Query: 5516 ---EEENLDRLHQQEKENPDSFLNH---VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ 5569
+ E L + ++ ++ +S H + L P ++ LN ++ + + +
Sbjct: 3851 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV--EEKYQKAE 3908
Query: 5570 NMNRQW---IRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPE 5626
NM Q +R A AL+ Q + E +KIE L+ +L
Sbjct: 3909 NMYAQIKEEVRQRALALDEAVS-QSTQITE-----------FHDKIEPMLE-----TLEN 3951
Query: 5627 LLEQQKTYKMLEAEVS-INQTIADSY-VTQSLQLLDTT--EIENRPEFITEFSKLTDRWQ 5682
L + + ++ AEV I + I+D+ T L+ L + ++ R E + S+ D+
Sbjct: 3952 LSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDL 4011
Query: 5683 NAVQGVRQRKGDVDGLVRQWQD-----------FTTSVENLFRFLTDTSHLLSAVKGQER 5731
A ++ + +D +V W+D F +E +F D + LL+ +K
Sbjct: 4012 AA----KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK---- 4063
Query: 5732 FSLYQTRSLIHELKNKEIH--FQRRRTTCALTLEA---------------GEKLLLTTDL 5774
T+ ++H+L++ I +++ A T++ G L+
Sbjct: 4064 ----DTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4119
Query: 5775 KTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQ--VLKAQ 5832
K V + I ++ ++W+++ E +++ + ++ Q + ++ + L V+K
Sbjct: 4120 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4179
Query: 5833 SEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD----LTRHVLVEDVMVLK 5888
+ +P + DL+ K+ + E+++ Q E++ + L + D +++
Sbjct: 4180 T---MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIR 4236
Query: 5889 EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI 5948
E + L WE+L ++A R+ ++E L F +EL +WL E + IS
Sbjct: 4237 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4296
Query: 5949 EEMI---EKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQ 6004
+ + E + ++ L + ++ + + G++L+++S A+ + +L +N W+
Sbjct: 4297 DPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWE 4356
Query: 6005 HLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKR 6062
+ R ++L+ T Q + + L R+ES+LS KP + +
Sbjct: 4357 SVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT-------GGLPET 4409
Query: 6063 LAEQQDLQRDIEQHSAGVESVFN-ICD-----VLLHDSDACANETECDSIQQTTRSLDRR 6116
EQ D ++ E +N + D +L D ++TE Q+ L+++
Sbjct: 4410 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE-----QSVALLEQK 4464
Query: 6117 WRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEEL 6176
W + + ER+ K+EE L +F + F +WL AE++ + ++ + ++
Sbjct: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 4524
Query: 6177 KRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAV 6236
+ + F +++ Q+ +++ +L ++ +K ++ RW+ + +R
Sbjct: 4525 EEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER 4584
Query: 6237 LRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLN---GFQQEI 6293
R L + ++F + ++ WL + + L + S +D D QL+ FQ+ +
Sbjct: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTL 4643
Query: 6294 TLNTNKIDQLIVFGEQLIQKS-EPLDAVLIEDELEELHRYCQEVFGR-VSRFHR 6345
D I G L +K+ P D+ +++ L E+ V G+ V R H+
Sbjct: 4644 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 4697
Score = 205 bits (521), Expect = 1e-51
Identities = 147/439 (33%), Positives = 215/439 (48%), Gaps = 79/439 (17%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT W+N L + I+DL+ D++ GH L+ LLEVLSG +LPR+KG
Sbjct: 75 ERDRVQKKTFTKWVNKHLMKVRKH--INDLYEDLRDGHNLISLLEVLSGIKLPREKGRMR 132
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL FL+ R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 133 FHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 183
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ + S MSA++ LLLW Q+ A Y + T+F
Sbjct: 184 -------DIYISGESG----------------DMSAKEKLLLWTQKVTAGYTGIKCTNFS 220
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
S W +G F A+IH RPDL+DM+ V+ +SN++NL +AF +AE+ L + RLL+ EDVDV
Sbjct: 221 SCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVP 279
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE------------EAQGKVKDAMGWLTLQKEKLQK 315
PDEKS++TYV+ P GE E Q +V + W+ Q L
Sbjct: 280 SPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIK-QHTILMS 338
Query: 316 LLKDSENDTYFKK-YNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAWDGLD 374
+N K YN + F E+ ++L+ +R+ +++ + +L E W
Sbjct: 339 DKTFPQNPVELKALYNQYIHFKET---------EILAKEREKGRIEELY-KLLEVW---- 384
Query: 375 HQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQ---------- 424
I +IKL P E W + + E+++ + S + L+Q
Sbjct: 385 --IEFGRIKLPQGYHPN-DVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGAL 441
Query: 425 ---EKMTLFKSLMDRFEHH 440
EK+TL K+ + H
Sbjct: 442 NCEEKLTLAKNTLQADAAH 460
Score = 194 bits (493), Expect = 3e-48
Identities = 338/1738 (19%), Positives = 664/1738 (38%), Gaps = 205/1738 (11%)
Query: 4740 QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ-----KLVADMLLIQ 4794
QDAL + ++ + +E +A+ + KV ++AQI+ K+ + K DML +
Sbjct: 3283 QDAL-EPLLSWLADTEELIANQKPPSAEYKV-VKAQIQEQKLLQRLLDDRKATVDMLQAE 3340
Query: 4795 ----AYSAKI-----LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDE 4845
A SA++ + L++ E+ W E +++ +++ L+ +L ++F E
Sbjct: 3341 GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ-------LEDILVLAKQFHE 3393
Query: 4846 NYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQL 4905
+ L + L + V ++ ++I ++ ++ +I ++Q + G+ L
Sbjct: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453
Query: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS----YNRDSDQLTKWLE 4961
+S++ P +G +++ + + +I R ALL LS + D ++ WL
Sbjct: 3454 -SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLA 3512
Query: 4962 SSQHTLNYWKEQSLNVSQ-DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
+ L+ S+ V D + + ++E+ + I G LL K+
Sbjct: 3513 EVEDKLS-----SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL--KQ 3565
Query: 5021 T---DTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEH 5077
T + ++ L + ++ + L Q + + E+ W+ VE
Sbjct: 3566 TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE 3625
Query: 5078 QTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYER 5137
+ + SP+ Q+ Q+ KE + E+ + ++D VN+ +S +E +
Sbjct: 3626 ELATSGG-QSPTG-EQIPQFQQRQKELKKEVMEHRLVLDTVNE----VSRALLELVPWRA 3679
Query: 5138 TEFAEHL-GEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL 5196
E + L + N Q+ V + +++ ++ ++ + E W+ + +L L
Sbjct: 3680 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 3739
Query: 5197 QKPESVISVQKLLLDCQDIENQLAI-KSKALDELKQSYLTLESGAVPLLEDTASRIDELF 5255
+ L+ QL + K+ ++D ++ +DELF
Sbjct: 3740 GP---------IRLEQDQTTAQLQVQKAFSIDIIRHK----------------DSMDELF 3774
Query: 5256 QKRSSVL-----TQVNQLKTSMQSVLQEWKIYDQLYDE-------VNMMTIRFWYCMEHS 5303
RS + Q L+ +S++Q+++ L E ++ +FW E
Sbjct: 3775 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 3834
Query: 5304 KPVV--------------LSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCP 5349
P + + E LR Q E ++ L++ + +KL ++ +LK L P
Sbjct: 3835 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP 3894
Query: 5350 SVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQ 5409
E++EEK Q + Q+ + + + + + H + E +
Sbjct: 3895 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKI-------EPMLE 3947
Query: 5410 QLANISMSGNNLAEILPPALQDIKELQHD----------VQKTKEAFLQNSSVLDRLPQP 5459
L N+S S + ++P + I+E D +Q + EA + L Q
Sbjct: 3948 TLENLS-SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
Query: 5460 AESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL-ESLKGLIMHEEE 5518
A+ + L + + + + +A E E + + + L+ ++
Sbjct: 4007 ADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
Query: 5519 NLDRLHQQEKE--NPDSFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAV--------- 5565
D +H E +P V A + + L+E +++ +D+
Sbjct: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
Query: 5566 --KTLQNMNRQWIRATATALERCSEL----QGIGLNEKFLYCCEKWIQLLEKIEEALKVD 5619
K++ MN W T ER +L Q + L W+ I+
Sbjct: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPP 4183
Query: 5620 VANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE-FSKLT 5678
V L + +Q K + EV Q + Q +L E + I E ++L
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELK 4243
Query: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSA---VKGQERFSLY 5735
W+N + + R+ ++G + F ++E L +LT T LL A + G +
Sbjct: 4244 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEV 4303
Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
+ H LKN + Q T +AG +LL ++ S+ R+ + W+ +
Sbjct: 4304 ELAKH-HVLKNDVLAHQ---ATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359
Query: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ--SEDP---LPEL-HEDLHNEKE 5849
+ E +Q QST++ +I++ L +++Q + P LPE E L E
Sbjct: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4419
Query: 5850 LIKELEQSLASWTQNLKELQTM---KADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
L +L+ ++ Q L + + M + D E + L EQ +W + ++
Sbjct: 4420 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKME 4473
Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK---------VLQTADISIEEMIEKLQK 5957
RK ++E+ LN F +E WL E +L T IEE K
Sbjct: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE-----HK 4528
Query: 5958 DCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
E+N + ++L Q G+QL S K I + L + RW+ + R + L
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
Query: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
+ +Q + L WL ES L + D +I+ +L++ ++ Q+ +
Sbjct: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN-DPDKIKLQLSKHKEFQKTL---- 4643
Query: 6078 AGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR-------RWRNICAMSMERRMK 6130
G + V+ D + A +T + + ++ LD +W +C S+ER+ K
Sbjct: 4644 GGKQPVY---DTTIRTGRALKEKT---LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 4697
Query: 6131 IEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERL 6190
+EE +F+D DWL E A + + FQ+++ +R
Sbjct: 4698 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 4757
Query: 6191 TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEF 6250
++++ + R L +R DT + +K + E + RWD + + + RL Q E F
Sbjct: 4758 GTVQVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF 4816
Query: 6251 EGTRESILVWLTEMDLQLTNVEHFSESDADD--KMRQL----NGFQQEITLNTNKIDQLI 6304
T +L WL+E + L F + DD ++ L F +++ ++ +
Sbjct: 4817 RDTVHMLLEWLSEAEQTL----RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAV 4872
Query: 6305 VFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASE 6362
GE ++ P I+ + + +EV + +RL + L E E
Sbjct: 4873 AMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE 4930
Score = 192 bits (488), Expect = 1e-47
Identities = 675/3678 (18%), Positives = 1403/3678 (38%), Gaps = 555/3678 (15%)
Query: 2883 ELQEIDSGISTHLQELTNIYEE---LNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE-- 2937
E +I + H ++ + +V +RL LE++++ K R + + ++N E
Sbjct: 985 ECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEET 1044
Query: 2938 ----------------VEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEI 2981
E++ + ++ S+ + + D+ Q N L + ++ + +E++
Sbjct: 1045 VAKMYISELKNIRLRLEEYEQRVVKRIQSLASS-RTDRDAWQDNALRIAEQ--EHTQEDL 1101
Query: 2982 YNLKDRLTAIKCCILQVLKLKKVFDYI-----GLNWDFSQLDQ---LQTQVFEKEKELEE 3033
L+ L A+ L + LN ++D L T K K ++
Sbjct: 1102 QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDV 1161
Query: 3034 KIKQLDTFEEEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRI 3091
++ + E Y+ LS+ + DL + L+ S + + +L + I
Sbjct: 1162 IVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEI 1221
Query: 3092 EKAKCLCDEIIKKLNENKTFDDSFKEK----------EILQIKLNAEENDKLYKVL--QN 3139
KAK + +++ + E + ++EK I Q+++ E + + +VL
Sbjct: 1222 AKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYR 1281
Query: 3140 MVLELSPKELDEKNCQDKLETSLHVLNQ--IKSQLQQPLLINLEIKHIQNEKDNCEAFQE 3197
K ++E Q ++ + + QL Q + EI+ Q + D C+ F +
Sbjct: 1282 ACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQ 1341
Query: 3198 QVWA-------EMCSIKA-VTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRT- 3248
Q ++ + KA V + +K + S + +EF DL+ + + L T
Sbjct: 1342 QYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQ 1401
Query: 3249 --NVLNDAYENLTRYKEAVTRA----VESITSLEAIIIPYRVDVGNPEESLEMPLRKQEE 3302
++DA L ++ V VE + L + + S E ++ +
Sbjct: 1402 HVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSE--TKESTD 1459
Query: 3303 LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNS-AMKEAFKAQETEAERYLENY 3361
+E + Q L+E+L + E + T Q ++K+ + E K Q +E L
Sbjct: 1460 IEKAILEQQVLSEEL--TTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN-- 1515
Query: 3362 KCYRKMEEDIYTNLSKMETVLGQSMSSLPL-----SYREALERL-------------EQS 3403
K Y + + L ++++ L L + + LE L Q
Sbjct: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575
Query: 3404 KALVSNLISTKEELMKLRQILRLLRLRCT--------------ENDGICLLKIVSALWEK 3449
+ +L + ++ L+ + ++ R T EN + ++AL EK
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635
Query: 3450 WLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSE 3509
L AKE E L++E + +E+E + LQ+ E K+K A E +
Sbjct: 1636 ----LHQAKE---QYEALQEETRVAQKELEE--AVTSALQQ---ETEKSKAAKELAENKK 1683
Query: 3510 LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQ 3569
+D L + +V L L + + GA++T + + N+ +
Sbjct: 1684 KIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGV-------NQAPE 1736
Query: 3570 KVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILK 3629
K+ K E+++ RH +E+++ + F T S Q AF D + EE Q + +
Sbjct: 1737 KLDKQCEMMKA----RH---QELLSQQQNFILATQSAQ--AFLDQHGHNLTPEEQQMLQQ 1787
Query: 3630 K-GKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAM 3688
K G+L E Y+ A+ E+++++ + +++ + + + S
Sbjct: 1788 KLGEL-------------KEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERS 1834
Query: 3689 RRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQD 3748
+++E ++ G + E + + ++++ D + S LD E ++
Sbjct: 1835 EKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 1894
Query: 3749 PGQAQEWM-DNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIE----N 3803
P + + D L ++Y + + S LN + ++ + S +AW++ N
Sbjct: 1895 PSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEAN 1954
Query: 3804 TSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL--LHSIFMDLEDLS--------- 3852
LL++ D A+T Q+ E +E + + L + D+ ++
Sbjct: 1955 VEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRH 2014
Query: 3853 IIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTI 3912
+ TD + Q LS + + +++ Q Q + + + ++ + +E+ + +
Sbjct: 2015 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS 2074
Query: 3913 LLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQ 3972
LS + + ++K + I ++ T E+V+ +E T +Q
Sbjct: 2075 SLSSGVIQEALATNMKLKQDIARQKSSLEAT-REMVTRFMETADSTTAAVLQGKLAEVSQ 2133
Query: 3973 LLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQ---- 4028
+ + L + QE+ LK ++ Q ++ L+Q + N S + + PDQ
Sbjct: 2134 RFEQLCLQQ---QEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN-QPDQDITH 2189
Query: 4029 -ADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKAT--VLNLHQHLKQEQ----EGVERD 4081
++ +L E+E ++ + +L E L+ +L + L+L QH + Q + E
Sbjct: 2190 FFQQIQELNLEMEDQQENLDTL----EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ 2245
Query: 4082 RLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEV--EESSVKSDNGDEKAEPSPQS 4139
+ ++ + E + R +L E + E+S+ + +++ E
Sbjct: 2246 KTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE----- 2300
Query: 4140 WSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPN 4199
H K + +D A S GT+V+E K ++ +N + +I PDS
Sbjct: 2301 ------HLKSLLDDWA--SKGTLVEEINCKGTSLENLIMEITAPDS-------------- 2338
Query: 4200 QTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAV 4259
Q + G+ P ++ S + H CK + E++ + N+
Sbjct: 2339 QGKTGSILPSVGSSVGSVNG------------------YHTCK-DLTEIQCDMSDVNLKY 2379
Query: 4260 EPETLNADMQQVLEQQLVGCQAMLTEIE--HKVA-FLLETCKDQGLGDNGATQHEAEALS 4316
E + VL ++ QA+L +E HK A +L+ + + + +A +
Sbjct: 2380 E------KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSP 2430
Query: 4317 LKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKS--------SEPEHQEALQPVNLSELES 4368
K +TVK E + L E E P I K + P QEA N +++
Sbjct: 2431 TKTETVKAQAESNKAFLAE--LEQNSPKIQKVKEALAGLLVTYPNSQEA---ENWKKIQE 2485
Query: 4369 IVTERPQFSRQKDFQQQQVLE---------------LKP-MEQKDFIKFI---------E 4403
+ R + + + +Q+ LE L+P + +K+ + +
Sbjct: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM 2545
Query: 4404 FNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKI 4463
NA+K Q+ +E A Q N+ IL+ G +
Sbjct: 2546 LNAQKQQVQF------MLKEFEARRQQHEQLNEAAQGILTGPGD---------------V 2584
Query: 4464 KLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEAS---------- 4513
L Q+ + S N + N R ++ +TQ ++L Q+ S
Sbjct: 2585 SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 2644
Query: 4514 NLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEML----EMPRLYREDGSGQQV--H 4567
++Q+ + EA ++ E+ L Q V+E E+ L E ++
Sbjct: 2645 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 2704
Query: 4568 YETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKS 4627
ET+AL L+ L +D+ L A+ +T + FD L+ L+ Q S+
Sbjct: 2705 LETVALPLQGLEDLAADRINRLQAALA----STQQFQQMFDELRTWLDDKQ------SQQ 2754
Query: 4628 LKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAES 4687
K N +++RL QL + Q+SLN+ SG +Y V + ES
Sbjct: 2755 AK-----NCPISAKLERLQSQL-QENEEFQKSLNQHSG-----------SYEVIVAEGES 2797
Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGM 4747
+ + E+ L ++ +L++ + + R + L + ++ +
Sbjct: 2798 LLLSVPPGEEK----RTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 2853
Query: 4748 VELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV--ADMLLIQAYSAKILPSLL 4805
V ++ K K++ L+ T V L++ + K ++ +L I +A IL +
Sbjct: 2854 VPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 2911
Query: 4806 QNRETFWAEQVTEVK-----ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLE----- 4855
+ E ++ + + EE + G L+ + Q+ EF E++ ++EK +E
Sbjct: 2912 EADEDGIRDEKAGINQNMDAVTEELQAKTG-SLEEMTQRLREFQESFKNIEKKVEGAKHQ 2970
Query: 4856 -ILISTLPSVSLVEETEERLVERISFYQQIKRNI----------------GGKHARL--- 4895
+ L S + + E+L + Q ++ + G ++L
Sbjct: 2971 LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQ 3030
Query: 4896 ----YQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNR 4951
Q E KQ V S C +E ++ + Q+ +++ +L L L + + R
Sbjct: 3031 AEVAQQEFLEVKQRVNS-GCVMMENKLEGI-GQFHCRVREMFSQLADLDDELDGMGAIGR 3088
Query: 4952 DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISI 5011
D+D L +E + LN L D++ + + E +D LK + ++
Sbjct: 3089 DTDSLQSQIEDVRLFLNKIHVLKL----DIEASEAECRHMLEEEGTLD-LLGLKRELEAL 3143
Query: 5012 GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW 5071
Q L E A +++ + + ++ D KL L + +A E + W
Sbjct: 3144 NKQCGKLTERGKAR--------QEQLELTLGRVEDFYRKLKGLNDATTAAEEA--EALQW 3193
Query: 5072 MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLS--TCD 5129
+ E + ++ + QK + ++M +Q V+ + Q L+Q + CD
Sbjct: 3194 VVGTEVEIINQQLADF--------KMFQKEQVDPLQMKLQQ--VNGLGQGLIQSAGKDCD 3243
Query: 5130 VESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQ 5189
V+ ++ + E+N +W+ ++ + ++I L++ L + ++ ++ L +WL
Sbjct: 3244 VQGLEHD-------MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADT 3296
Query: 5190 EERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTAS 5249
EE + + P + V K + Q + +L KA ++ Q+ E G + + A
Sbjct: 3297 EELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQA----EGGRIAQSAELAD 3352
Query: 5250 R------IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHS 5303
R ++ L + + +L++ + ++ +L K + + + ++ + +S
Sbjct: 3353 REKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS 3412
Query: 5304 KPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL-CPSVAEIIEEKCQNT 5362
+PV ++ Q+ ++L+++ E+ + ++ L L P+ ++ EK +
Sbjct: 3413 EPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSL 3472
Query: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH--GEAAARLKQQEAKFQQLANISMSGNN 5420
R+++ I D+ + +LL +A SNA GE + A+ + + +
Sbjct: 3473 QARYSE----IQDRCCRKAALLD--QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 3526
Query: 5421 LAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAY 5480
++L D L ++ K+ Q L + +L+ L + + Y
Sbjct: 3527 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-KTRY 3585
Query: 5481 LEKMLLVKANEFEFVLSQFKDFGVRLES----LKGLIMHEEENL-------------DRL 5523
+ + V +++ L Q + + +S L G + EE L +
Sbjct: 3586 AD--ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 3643
Query: 5524 HQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKL------PLSDVAVKTLQNMNRQWIR 5577
Q++KE + H L L + +NEVS L + K + + N Q+
Sbjct: 3644 QQRQKELKKEVMEHRLVL-------DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKL 3696
Query: 5578 ATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKML 5637
+ T +R E+ IQ ++ E+A ++A ++K +
Sbjct: 3697 VSDTIGQRVDEIDAA-------------IQRSQQYEQAADAELAWVAE---TKRKLMALG 3740
Query: 5638 EAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDG 5697
+ +QT A V ++ + ++ E + S++ + V Q K +
Sbjct: 3741 PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK--TES 3798
Query: 5698 LVRQWQDFTTSVENLFRFLTDTSHLLSAV-KGQERFS--LYQTRSLIHELKNKEIHFQRR 5754
L++Q++ + + L L++ + E S + +TR+LI +L + I ++
Sbjct: 3799 LIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQL 3858
Query: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQ-FQSTVETWD 5813
R + E L + + ++ ++ K++ P+ EM+++ +Q +
Sbjct: 3859 RQ------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYA 3912
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q ++++++ L +QS + E H+ + E ++ L L + L +
Sbjct: 3913 QIKEEVRQRALALDEAVSQSTQ-ITEFHDKIEPMLETLENLSSRL-----RMPPLIPAEV 3966
Query: 5874 DLTRHVLVE------DVMVLKEQIEHLHRQWEDLCLRVA-----IRKQEIEDRLNTWVVF 5922
D R + + ++ L+ E L R+ E+L R + +EI+D+L+ V F
Sbjct: 3967 DKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFF 4026
Query: 5923 NEKNK--------------ELCA--W--LVQMENKVLQTADI-------SIEEMIEKLQK 5957
E K EL W + + + T DI I+ I K Q
Sbjct: 4027 WEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQV 4086
Query: 5958 DC----MEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR 6013
+ EE + E ++ +G LI A ++ E+ ++++N+ W++L R
Sbjct: 4087 EAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4146
Query: 6014 VKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCDDQEIQKRLAEQQDLQR 6071
++KL++ Q + + WL +L PV D+ ++ +L E ++ +
Sbjct: 4147 LEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL---NTVKDQLNEMKEFKV 4203
Query: 6072 DIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKI 6131
++ Q +E + + +++L + +ET+ D I++ L W N+ R+ K+
Sbjct: 4204 EVYQQQIEMEKLNHQGELMLKKA---TDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4260
Query: 6132 EETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLT 6191
E +F WL E + EL + + +
Sbjct: 4261 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQA 4320
Query: 6192 QLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFE 6251
+E +NK L + D AS L+ + NQ W+++ ++ ++L+ Q + F
Sbjct: 4321 TVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH 4380
Query: 6252 GTRESILVWLTEMDLQLT 6269
E L+ LT M+ QL+
Sbjct: 4381 SEIEDFLLELTRMESQLS 4398
Score = 155 bits (392), Expect = 1e-36
Identities = 648/3474 (18%), Positives = 1317/3474 (37%), Gaps = 477/3474 (13%)
Query: 3115 FKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETS-----LHVLNQIK 3169
FKE EIL + ++LYK+L+ + +E +L + + +E + +L + K
Sbjct: 359 FKETEILAKEREKGRIEELYKLLE-VWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREK 417
Query: 3170 SQLQQPLLINLEI-----KHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEAS 3224
S +P + LE+ IQN NCE E++ +++A A + + E S
Sbjct: 418 S--LRPAVERLELLLQIANKIQNGALNCE---EKLTLAKNTLQADAAHLESGQPVQCE-S 471
Query: 3225 DVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRV 3284
DV ++E E L QL +DL+ +L D EN + +E R + L+ ++ R+
Sbjct: 472 DVIMYIQECEGLIRQL--QVDLQ--ILRD--ENYYQLEELAFR----VMRLQDELVTLRL 521
Query: 3285 DVGNPEE-----SLEM--------------PLRKQEELESTVAHIQDLTE-KLGMISSPE 3324
+ N SLE+ PL K ST + +T +L ISS E
Sbjct: 522 ECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSE 581
Query: 3325 AKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQ 3384
+ L++ + EL+S M+ K + E L + + + ++ I+T++ + LG
Sbjct: 582 DEGNLRF-VYELLSWVEEMQ--MKLERAEWGNDLPSVELQLETQQHIHTSVEE----LGS 634
Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVS 3444
S+ L + + S A + T+ +K R+ L+ L K VS
Sbjct: 635 SVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQ-------SLHKFVS 687
Query: 3445 ALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATT 3504
+ + L E + EEL +W + I + L EL E K +
Sbjct: 688 RATAELIWLNEKEE------EELAYDWSDNNSNISAKRNYFSELTMELEE--KQDVFRSL 739
Query: 3505 EELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERC 3564
++ +ELL L+ + Q V S AV++ ++ MK+ C
Sbjct: 740 QDTAELLS-------------------LENHPAKQTVEAYSAAVQS-----QLQWMKQLC 775
Query: 3565 NKLLQKVQKNKELVQ--TEIQERHSFTKEI-IALKNFF---QQTTTSFQNMAFQDHPEKS 3618
+ Q V++N Q ++ +E SF + + ++K + T+ S QD ++
Sbjct: 776 LCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEK 835
Query: 3619 EQFEELQS------------ILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRK 3666
EQ + +S + K + + + +K Y + I + +EC
Sbjct: 836 EQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITI-CKNDEC-- 892
Query: 3667 ALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDE 3726
LED ++ +V+ + + AM + + + K + + +E++ + +W +
Sbjct: 893 VLEDNSQRTKWKVISPTGNEAM---VPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQ 949
Query: 3727 LDL-------WHSKLNELDS----EVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC 3775
L + W+ +LD ++ + PG+ + M NL ++ + Q +
Sbjct: 950 LHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQ-----DS 1004
Query: 3776 RTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLS----HHASTVQMAL 3831
R S L ++ L + EA HL+ + + D T++ +++ L
Sbjct: 1005 RDSVLFSVADRLR----LEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRL 1060
Query: 3832 EDSEQK-HNLLHSIFMDLEDLSI-------IFETDELTQSIQELSNQVTALQQKIMESLP 3883
E+ EQ+ + S+ D I E + + +Q+L + + A+ K L
Sbjct: 1061 EEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLH 1120
Query: 3884 QIQRMADDVVAIESEVKSMEKR-----------VSKIKTI------LLSKEIFDFSPEEH 3926
Q + V + SE+ + ++ ++K+KT+ + E+ E
Sbjct: 1121 Q-SPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIK 1179
Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELR--------LPQTGMKPLPVFQRTNQLLQDIK 3978
L EV+L ++ ++ + + + +++ L + K V ++ ++L +
Sbjct: 1180 LSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERN 1239
Query: 3979 L-LENVTQEQNELLK---VVIKQTNEWDEEIENLKQILNNYSA------------QFSLE 4022
L LE ++ ++L + VI Q E+E+++++L +Y A E
Sbjct: 1240 LDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQE 1299
Query: 4023 HMSPDQA-------DKLPQ---LQGEIERME---KQILSLNQRKEDLLVDLKATVLNLHQ 4069
M P QA ++L Q L EIER + Q +Q+ ++ D + ++
Sbjct: 1300 MMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKA 1359
Query: 4070 HLKQEQEGVERDR-----LPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSV 4124
++ +Q+ + R A+T E + R + L + A+ EE V
Sbjct: 1360 FVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKV 1419
Query: 4125 KSDNGDEKAEPSPQ--SWSSLWKHDKDMEEDRASSSSGTIVQEAY-------GKISTSDN 4175
+ E E + W S + + + + T +++A +++T
Sbjct: 1420 VEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKE 1479
Query: 4176 SMAQ-ILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
+++ I T + G + S + + + D D +++
Sbjct: 1480 QVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQ 1539
Query: 4235 TE------VLHACKTQVAELELWLQQANVAV---EPETLNADMQQVLEQQLVGCQAMLTE 4285
TE + C Q+ +L W+ QA A+ + T D+ L++ + + +
Sbjct: 1540 TEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL-SALQKNQSDLKDLQDD 1598
Query: 4286 IEHKVAFLLETCKD-QGLGDNGATQ---HEAEALSLKLKTVKCNLEKVQ--MMLQEKHSE 4339
I+++ KD +G + T+ E AL KL K E +Q + +K E
Sbjct: 1599 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 1658
Query: 4340 DQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFI 4399
+ + L++ +E N ++++++ Q + L MEQ
Sbjct: 1659 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGG---QLLTNLPGMEQLSGA 1715
Query: 4400 KFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHEL 4459
+E A DTT NQA P+ + + + + H EL
Sbjct: 1716 S-LEKGAL-----------DTTDGYMGVNQA-------PEKL----DKQCEMMKARHQEL 1752
Query: 4460 SSKIK--LPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQT 4517
S+ + + Q + + + L + E + Y+T L E +QT
Sbjct: 1753 LSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQT 1812
Query: 4518 QENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLE-------MPRLYREDGSGQQVHYET 4570
++ ++ D K FE +L S+ +E M + +P L + GS + +
Sbjct: 1813 LQDELQK--FLQDHKEFESWLERSE--KELENMHKGGSSPETLPSLLKRQGSFSE---DV 1865
Query: 4571 LALELKKLYLALSDKK----GDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
++ + ++ +S +K + K P E NL+ D L+ + T+ SK
Sbjct: 1866 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVK---DKLK---DATERYTALHSK 1919
Query: 4627 SLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQ-------QSLNEISGQSVA-------EQL 4672
+ G S+ N + YHQ S SLQ ++ ++ +VA EQL
Sbjct: 1920 CTRLG-----SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 1974
Query: 4673 QKADAYTVELENAESRVAKL----RDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYT 4728
EL + V KL RD E P + V + D + S + L
Sbjct: 1975 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2034
Query: 4729 ELSS---PFVTESQQ-----DALLQ--GMVELVKIGKE--KLAHGHLKQ----------- 4765
E SS + +SQ ++LLQ G VE GK+ L+ G +++
Sbjct: 2035 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2094
Query: 4766 -TKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEE 4824
+ K +L+A E F + AD K L + Q E +Q + L++
Sbjct: 2095 IARQKSSLEATREMVTRFME--TADSTTAAVLQGK-LAEVSQRFEQLCLQQQEKESSLKK 2151
Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASL-------EKDLEILISTLPSVSLVEE-------T 4870
Q M + L K ++F EN + + ++D+ + ++L E T
Sbjct: 2152 LLPQAEM-FEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2210
Query: 4871 EERLVERISF---------YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKL 4921
E LV +S +Q +N+ L +T+ E ++ + SC E + KL
Sbjct: 2211 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK--DASSCQEQLDEFRKL 2268
Query: 4922 EEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
+ K+ + + + + + +L K +E + L+ W + V +++
Sbjct: 2269 VRTFQKWLKETEGSIPPTET--------SMSAKELEKQIEHLKSLLDDWASKGTLV-EEI 2319
Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE----TDTATLRASLAQFEQKW 5037
+ +++ N D + + + S+G+ + + D ++ ++ K+
Sbjct: 2320 NCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKY 2379
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHL 5097
L L + QE L + K ++ W+ + E D++ SP+ VK
Sbjct: 2380 EKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQ 2439
Query: 5098 LQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGM 5157
+ +K F E++ + V ++L L S+ E + + E+N +W R +
Sbjct: 2440 AESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQE--ELNSRWERATEV 2497
Query: 5158 LNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIEN 5217
+ + LE+ + + L WL +E + L +S+ +L+ Q +
Sbjct: 2498 TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL----GPLSIDPNMLNAQKQQV 2553
Query: 5218 QLAIKS--------KALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLK 5269
Q +K + L+E Q LT + + QK + ++N
Sbjct: 2554 QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS 2613
Query: 5270 TSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES 5329
+ + + + Y +L +++ + + E ++ Q+E ++ + E
Sbjct: 2614 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQ 2673
Query: 5330 SEGSWEKLQEVIGKLKGLCPS--VAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLW 5387
+ ++ Q + +L L + + ++++ + + AD++ + Q+ L
Sbjct: 2674 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 2733
Query: 5388 KAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF- 5446
+ + E L +++ QQ N +S E L LQ+ +E Q + + ++
Sbjct: 2734 QQFQQMFDELRTWLDDKQS--QQAKNCPISAK--LERLQSQLQENEEFQKSLNQHSGSYE 2789
Query: 5447 ---LQNSSVLDRLPQPAESST--HMLLPGPLH-------SLQRAAYLEKMLLVKANEFEF 5494
+ S+L +P E T + L+ H + R + L K + KA ++++
Sbjct: 2790 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRL-KDCMQKAQKYQW 2848
Query: 5495 ----VLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEH 5550
++ +D ++ L+ + + L + N +L + + DI
Sbjct: 2849 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 2908
Query: 5551 LNEVSLKLPLSDVAVKTLQNMN--RQWIRATATALE----RCSELQGIGLN-EKFLYCCE 5603
+ + + + D QNM+ + ++A +LE R E Q N EK + +
Sbjct: 2909 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 2968
Query: 5604 KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE 5663
+++ + + + +L +L QQ+ + LE +V + V + D ++
Sbjct: 2969 HQLEIFDAL--GSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ 3026
Query: 5664 IENRPEFI-TEFSKLTDR-------WQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRF 5715
+ ++ E EF ++ R +N ++G+ Q V + Q D ++ +
Sbjct: 3027 LLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAI 3086
Query: 5716 LTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLK 5775
DT L S ++ F + IH LK + + C LE L L +
Sbjct: 3087 GRDTDSLQSQIEDVRLF-----LNKIHVLK---LDIEASEAECRHMLEEEGTLDLLGLKR 3138
Query: 5776 TKESVGRRISQLQDSWKDMEPQL---AEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ 5832
E++ ++ +L + K + QL ++ F ++ + +E ++ V+ +
Sbjct: 3139 ELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTE 3198
Query: 5833 SEDPLPELHEDLHNEKELIKELE---QSLASWTQNLKELQTMKADLTRHVLVEDVMVLKE 5889
E +L + +KE + L+ Q + Q L +Q+ D DV L+
Sbjct: 3199 VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDC-------DVQGLEH 3249
Query: 5890 QIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE 5949
+E ++ +W L +VA R ++++ L F + + L +WL E + S E
Sbjct: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAE 3309
Query: 5950 EMIEKLQKDCMEEINLFSENKL----QLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
+ K Q + + +++ L+ G ++ +++ + +I +L + RW
Sbjct: 3310 YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTE 3369
Query: 6006 LFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCDDQEIQKRL 6063
L +R K+L++ +Q + + +L+ E +L S+PV +IQ+++
Sbjct: 3370 LLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA---KIQQQI 3426
Query: 6064 AEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAM 6123
+ L+ DIE H+ V I L + + E + + SL R+ I
Sbjct: 3427 IRHKALEEDIENHATDVHQAVKIGQSL----SSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482
Query: 6124 SMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAAC----PNSSEVLYTSAKEELKRF 6179
+ +++ + F +D +WL E + +VL+ + L
Sbjct: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHL--- 3539
Query: 6180 EAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRR 6239
A +I R ++ K + L ++ + +++ + R+ ++ + LR
Sbjct: 3540 -ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 3598
Query: 6240 LRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
L +F+ T E + WL E++ +L +S +++ Q Q+E+
Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELAT--SGGQSPTGEQIPQFQQRQKEL 3650
Score = 123 bits (309), Expect = 6e-27
Identities = 598/3292 (18%), Positives = 1233/3292 (37%), Gaps = 542/3292 (16%)
Query: 1125 ILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHV 1184
+LE + Q K+++ S +E S C + I+ + ++++L + HV
Sbjct: 893 VLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHV 952
Query: 1185 ND--------IKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCG 1236
N ++K + + L++ + M++L+ L + S+L
Sbjct: 953 NTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSV 1012
Query: 1237 SDLPLHKMAIQGFHLIDADRIYQHL------RNIQDSIAKQI--EICN---RLEEPGNFV 1285
+D + ++ +QHL + ++++AK E+ N RLEE V
Sbjct: 1013 ADRLRLEEEVEA-----CKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRV 1067
Query: 1286 LKELHPF-----DLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAE 1340
+K + D A Q+ L R+ E T + L+ + L + +
Sbjct: 1068 VKRIQSLASSRTDRDAWQDNAL-----------RIAEQEHTQEDLQQLRSDLDAVSMKCD 1116
Query: 1341 PVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKH--------LDKCLKMLDMSFKDAE 1392
S S + +V E++L+ +K H L+K LK +D+ + +
Sbjct: 1117 SFLHQSPSSS--------SVPTLRSELNLLVEKMDHVYGLSTVYLNK-LKTVDVIVRSIQ 1167
Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
E L+ + IKLS+ +E + LEA L +++D S S
Sbjct: 1168 -----DAELLVKGYEIKLSQ------EEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSV 1216
Query: 1453 IGLKDPTVPAVKHRKKSLIRLDKV----LDEYEEEKRHLQEMANSLPHFKDGREKTVN-- 1506
+ D + K + + RL L+ Y+E+ LQE + + + R+ +
Sbjct: 1217 L---DEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESI 1273
Query: 1507 -------QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVIS 1559
+ C T++ W +E+ E++K Q ++ V+S
Sbjct: 1274 QEVLGDYRACHGTLIKW----------IEETTAQQEMMKPGQ----------AEDSRVLS 1313
Query: 1560 LQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKE 1619
Q S AEIE + + ++ + + + + K+ + L K F E +
Sbjct: 1314 EQLSQQ-----TALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSP 1368
Query: 1620 ANIIVDRWLDINEK-TEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEED 1678
R L ++ T+++ + R AL L ++ AL+++E E+
Sbjct: 1369 GKR--RRMLSSSDAITQEFMDLRTRYTAL----VTLTTQHVKYISDALRRLE------EE 1416
Query: 1679 RERLKEELQVHEQKTSEFSRRVAEI----QFLLQSSEIP---------LELQVMESSILN 1725
+ ++EE Q H +K E V+ + Q SSE LE QV+ +
Sbjct: 1417 EKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTT 1476
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K E V + + A G +E Q Q+ L + +L++
Sbjct: 1477 KKEQVSEAIKTSQIFLAKHGHKLSEKEK-KQISEQLNALNKAYHDLCDGSA----NQLQQ 1531
Query: 1786 IQQQILQQKHSMILLENQIGC--LTPELSELKKQYESV-----SDLFNTKKSVLQDHFSK 1838
+Q Q+ Q L + Q C +L Q E S LQ + S
Sbjct: 1532 LQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 1591
Query: 1839 L--LNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDS 1896
L L D +N F+ + +++ E ++TK S + L K+ Q
Sbjct: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE----------LTALREKLHQAKE 1641
Query: 1897 VLKHVKKH--LPKAHVKELISWLVGQEFELEKMESICQARAKELEDSL-----------Q 1943
+ +++ + + ++E ++ + QE E K K+++ L Q
Sbjct: 1642 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 1701
Query: 1944 QLLRL----QDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQ---- 1995
L L Q +L K + + + G+ + EK + C+ + + ++ S Q
Sbjct: 1702 LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFIL 1761
Query: 1996 ----LNNSLKEYG--FTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFN 2047
L ++G T EE+ +++ L ++Y T L Q ++ + L E Q F
Sbjct: 1762 ATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFL 1821
Query: 2048 DLAHDVIHWIKEIKESLMVLN---SSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQA 2104
+ W++ ++ L ++ SS +P + Q ++ +GD R TI Q
Sbjct: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881
Query: 2105 ------------ESSE-APLVQKTLTDISNQWDNTLHLASTYL-SHQEKLLLEGEKYLQS 2150
E SE LV+ L D + ++ LH T L SH LL + ++ S
Sbjct: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERY-TALHSKCTRLGSHLNMLLGQYHQFQNS 1940
Query: 2151 KEDLRLMLIELKKKQEA---------------GFALQHGLQEKKAQLKI-YKKFLKKAQD 2194
+ L+ + + E A LQE+ A+ ++ +K K A+D
Sbjct: 1941 ADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD 2000
Query: 2195 LTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSY 2254
+ + E ++ E T + I +SL L + L + + S
Sbjct: 2001 IMEIEGEPAPDHRHVQETTDS----------ILSHFQSLSYSLAERSSLLQKAIAQSQSV 2050
Query: 2255 QVCVTDLNTTL----DNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKIL 2310
Q + L ++ N + VS V Q A+ ++ Q++ + S + T + +
Sbjct: 2051 QESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT 2110
Query: 2311 ALAKSVKQNTSSVGQ---KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
++ T++V Q + + L +Q++ E+ L + E + K ++
Sbjct: 2111 RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2170
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAM---SKQLSLNAQ 2424
E K + G Q D+ Q+ + ED + N D+ + S +L+
Sbjct: 2171 ENKSRMLASGN--QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC 2228
Query: 2425 ESMKNTEDERK-VNELQN--QPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECL 2481
+ ++ RK ELQ + E D EQL+E KL + K L++TE
Sbjct: 2229 QHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQ------KWLKETE-- 2280
Query: 2482 NKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLT 2541
G++ SA+ L+ ++ L +L + S+ ++ + ++E+ + +
Sbjct: 2281 -----GSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITA 2335
Query: 2542 DKESLKVGPLDSVTYLDKIKKFIASIEKE---KD------SLGNLKIKWENLSNHVTDMD 2592
K G + L + + S+ KD + ++ +K+E L + +
Sbjct: 2336 PDSQGKTGSI-----LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
Query: 2593 KKL--LESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHL- 2649
+ L + ++++++ V Q ++ K ++V++ + + K + + + + L
Sbjct: 2391 ESLQAILNRMEEVHKEANSVLQWLESK--EEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
Query: 2650 QLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEK------EKKNLE 2703
+L SP+ + +++ L ++ + K Q EL + W ++ LE
Sbjct: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR--WERATEVTVARQRQLE 2506
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILS 2763
+ ++L AE+Q++ + ++ ++G L P + + P+ + +
Sbjct: 2507 ESASHLA--------CFQAAESQLRPWLMEKEL---------MMGVLGP-LSIDPNMLNA 2548
Query: 2764 QIRKCKVTHDGILARQQSVESLAEEVKDKV--PSLTTYEGSDLNNTLEDLRNQYQMLVLK 2821
Q ++ + AR+Q E L E + + P + S + L+ + ++ L K
Sbjct: 2549 QKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDK 2608
Query: 2822 STQRSQQLEFKLEERSNFFAIIRKFQLMVQE-SETLIIPRVETAATEAELKHHHVTLEAS 2880
RS Q++ + + + + +++ V+ + L + + EA + T E
Sbjct: 2609 LNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEI- 2667
Query: 2881 QKELQEIDSGISTHLQELTNIYEELNVF-ERLFLEDQLKN----LKIRTNRIQRFIQNTC 2935
+ +L+++D + +E + +EL+V +L+D+LK + + ++ +
Sbjct: 2668 RSDLEQLDHEV----KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRI 2723
Query: 2936 NEVEHKIKFCRQFHEKTSALQEEADSIQ----------------RNELLLNQEVNKGVKE 2979
N ++ + +QF + L+ D Q +++L N+E K + +
Sbjct: 2724 NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ 2783
Query: 2980 EIYNLKDRLTAIKCCILQVL--KLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQ 3037
+ + + + +L V + K+ +QL +L+ E K+ ++ +
Sbjct: 2784 HSGSYEVIVAEGESLLLSVPPGEEKRTLQ--------NQLVELKNHWEELSKKTADRQSR 2835
Query: 3038 LDTFEEEHGKYQALLSKMRAIDLQIK-KMTEVVLKAPDSSPESRRLNAQILSQRIEKAKC 3096
L ++ KYQ + + K KM+E+ + ES L ++ + +EK +
Sbjct: 2836 LKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRS 2895
Query: 3097 LCDEIIKK-----LNENKTFDDSFK-EKEILQIKLNAEENDKLYKV--LQNMVLELSPKE 3148
L EI+ +N ++ +D + EK + ++A + K L+ M L +
Sbjct: 2896 LL-EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ 2954
Query: 3149 LDEKNCQDKLETSLHVL--------------NQIKSQLQQPLLINLE--IKHIQN----- 3187
KN + K+E + H L N K + QQ +L LE + +++N
Sbjct: 2955 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3014
Query: 3188 ---EKDNCEAFQEQVWAEMCS--------------------IKAVTAIEKQREENSSEAS 3224
D +A Q AE+ ++ + + E S+ +
Sbjct: 3015 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA 3074
Query: 3225 DVETKL-------REFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEA 3277
D++ +L R+ + LQ Q+ + L N ++ ++ + +E +L+
Sbjct: 3075 DLDDELDGMGAIGRDTDSLQSQIE-DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133
Query: 3278 IIIPYRVDVGNPE--ESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
+ + ++ N + + E +QE+LE T+ ++D KL ++ + LQ
Sbjct: 3134 LGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW 3193
Query: 3336 LVSKNSAMKEAFKAQETEAE---RYLENYKCYRKMEEDIYTNLSKMETVLGQSM------ 3386
+V TE E + L ++K ++K + D + LGQ +
Sbjct: 3194 VVG-------------TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3240
Query: 3387 ----SSLPLSYREALERLEQSKALVSNLISTKEELM----KLRQILRLL--------RLR 3430
L E R V+ I+ +E + K + L L L
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
Query: 3431 CTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIE---REAII--L 3485
+ K+V A ++ L + + + L+ E +++ E RE I L
Sbjct: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3360
Query: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
++L+ E+ +K AA ++L ++L Q+ E E L++ +++ + + V +
Sbjct: 3361 ESLESRWTEL-LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3419
Query: 3546 GAVE---------------------------------TVPAFQ-----EITSMKERCNKL 3567
++ T PA Q +I S++ R +++
Sbjct: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3479
Query: 3568 LQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSF---------QNMAFQDHPEKS 3618
+ + L+ + F ++ + + N+ + Q++ + H +
Sbjct: 3480 QDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHL 3539
Query: 3619 EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNE 3678
EE+ + K +N L+ E + I+ +++ + DI S
Sbjct: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLL----IQEKLDGIKTRYADITVTSSKA 3595
Query: 3679 VLKSSPSYAMRRKI----EEINNGLHNVEKML------QQKSKNIEKAQEIQKKMWDELD 3728
+ + + K EE+ L VE+ L + I + Q+ QK++ E+
Sbjct: 3596 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655
Query: 3729 LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF-QQYQQVSQRAECRTSQLNKATVKM 3787
L+ ++ + ++E P +A+E +D L+ +QY+ VS R +++ A +
Sbjct: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715
Query: 3788 EEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
++Y + AW+ T L L +T Q+ ++ + + H MD
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPI----RLEQDQTTAQLQVQKAFSIDIIRHKDSMD 3771
Query: 3848 --LEDLSIIFET---------DELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIE 3896
S IF T E T+S+ + ++ L + L + Q + +
Sbjct: 3772 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 3831
Query: 3897 SEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELR- 3955
E+ + + L S I + + + E+I K I +++ +L+
Sbjct: 3832 EELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE 3891
Query: 3956 -LPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQT--NEWDEEIENLKQIL 4012
P+ G +Q+ + IK E V Q L + V + T E+ ++IE + + L
Sbjct: 3892 LNPEEGEMVEEKYQKAENMYAQIK--EEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
Query: 4013 NNYSAQFSLEHMSPDQADKLPQLQG-------EIERMEKQILSLNQRKEDLL 4057
N S++ + + P + DK+ + E+E+++ +L +R E+L+
Sbjct: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001
Score = 122 bits (307), Expect = 9e-27
Identities = 749/4037 (18%), Positives = 1513/4037 (37%), Gaps = 677/4037 (16%)
Query: 167 PPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPD 226
PP K ++ +R + S +K + LW Q T + SW + LR D
Sbjct: 924 PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLI-------SW----------NYLRKD 966
Query: 227 LIDMKSVKHRSNKDNLREAFRIAEQEL-KIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYS 285
L + N + LR + A E +I + L+ D + S++ VA L+
Sbjct: 967 L----DLVQTWNLEKLRSS---APGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLE 1019
Query: 286 KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEND----TYFKKYNSLLSFMESFNE 341
++ K + Q L+K EN+ T K Y S L + E
Sbjct: 1020 EEVEAC------------------KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLE 1061
Query: 342 EKKSFLDVLSIKRDLDELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQE 401
E + + +KR + L R+AW Q NA +I L Q + L
Sbjct: 1062 EYEQRV----VKR-IQSLASSRTD-RDAW-----QDNALRIAEQEHTQEDLQQLRSDLDA 1110
Query: 402 VEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPN 461
V D L S S TL E L+++ +H + + NK +
Sbjct: 1111 VSMKCDSFLHQSPSSSSVPTLRSE----LNLLVEKMDHVYGLSTVYLNKLKT-------- 1158
Query: 462 KLEEMKRRINN--ILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV-ELL 518
++ + R I + +L K + + L L ++ S L W + SV +L
Sbjct: 1159 -VDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVL 1217
Query: 519 LEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVK 578
E+ K E ++RL E Y+ + Q +++ V + + + + + +++
Sbjct: 1218 DEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ---ERWHRVIAQLEIRQSELESIQ 1274
Query: 579 STLQKVLACWATYVENLRLLRACFEETK--KEEIKEVPFETLAQWNLEHATLNEAGNFLV 636
L AC T ++ + A E K + E V E L+Q A + L
Sbjct: 1275 EVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKL- 1333
Query: 637 EVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKA 696
+ ++ ++++ +V +L++ + Q + +LS +
Sbjct: 1334 ------------DQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAI 1381
Query: 697 TVEFSTDMSVELPENYNQNIKAGEKHEK---------ENEEFTGQLKVAKDVEK---LIG 744
T EF ++L Y + +H K E EE + + + VEK L+G
Sbjct: 1382 TQEF-----MDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLG 1436
Query: 745 QVEIW--EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQE 802
V + K+ + T +E K ++ + + +EL + E +S
Sbjct: 1437 WVSTLARNTQGKATSSETKESTDIE---KAILEQQVLSEELTTKKEQ--------VSEAI 1485
Query: 803 SFQHVLTTGLQAKIQEAKEKVQIN--VVKLIAALKNLTDVSPD----LDIRLKMEESQKE 856
+ K+ E KEK QI+ + L A +L D S + L +L + QK
Sbjct: 1486 KTSQIFLAKHGHKLSE-KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKT 1544
Query: 857 LESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLE 916
L+ Q Q E + + + AL ++ + L A+++ ++++ +D++ ++
Sbjct: 1545 LQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL-KDLQDDIQ 1600
Query: 917 EKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLI 976
++ + DIE G + +N KL +E +R +
Sbjct: 1601 NRATSFATVVK---------------DIE-GFMEENQTKLSP---RELTALREKLHQA-- 1639
Query: 977 KEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEI 1036
KE EE + Q V L +E K+ +E L + ++KI+ LL + +
Sbjct: 1640 KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKE----LAENKKKIDALLDWVTSV 1695
Query: 1037 ---------HMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTM 1087
++ G S +G + T++ G ++AP K D Q KA
Sbjct: 1696 GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGV--NQAP-EKLDKQCEMMKARH--- 1749
Query: 1088 KFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDR 1147
QE ++++ + S + L+ H N + EE +
Sbjct: 1750 -----------QELLSQQQNFILATQSA-------QAFLDQHGHN--------LTPEEQQ 1783
Query: 1148 SSSCLQAKLTDLQVIKN----ETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERE 1203
LQ KL +L+ + +++A K+ + + +L+ + D K+ L+ E
Sbjct: 1784 M---LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE-----FESWLERSE 1835
Query: 1204 RELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRN 1263
+EL+ ++ S ET L+ S + L + I G ++D + ++ +
Sbjct: 1836 KELE-NMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 1894
Query: 1264 IQDSIAKQIEICNRLEEPGNFVLKELHPFD-----LHAMQNIILKYKTQFEGMNHRVQRS 1318
E GN V +L LH+ + + G H+ Q S
Sbjct: 1895 PS--------------EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 1940
Query: 1319 EDTLKALEDFLASLRTAKLSAEPV-TDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHL 1377
D+L+A ++ + + E + +D ASD V QE T K + E+ + + L
Sbjct: 1941 ADSLQAW------MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 1994
Query: 1378 DKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNN 1437
K + + M + D + D+ +H + E + LL+ I ++
Sbjct: 1995 QKVARDI-MEIEGEPAPDHRHVQETTDSIL-----SHFQSLSYSLAERSSLLQKAIAQSQ 2048
Query: 1438 ELLKNIQDVQSQISKI--GLKDPTVPAVKHR--KKSLIRLDKVLDEYEEEKRHLQEMANS 1493
+ ++++ + I ++ L+ V ++ +++L K+ + +K L+
Sbjct: 2049 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2108
Query: 1494 LPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQK 1553
+ F + + T T + + A V++ EQ L Q Q +S L L+ +
Sbjct: 2109 VTRFMETADST-------TAAVLQGKLAEVSQRFEQ------LCLQQQEKESSLKKLLPQ 2155
Query: 1554 EESVISLQASYMG-KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
E L EN + +A ++ + + ++N ++ Q
Sbjct: 2156 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ---------- 2205
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
LD E + G AL L ++N+ ++TE LQK
Sbjct: 2206 -------------ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTE--LQKTVKE 2250
Query: 1673 QLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQK 1732
+ E+D +E+L + F + + E + + +E + + +E I EH++
Sbjct: 2251 R--EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQI----EHLKS 2304
Query: 1733 CLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSL-EIFTKLEEIQQQI- 1790
L + S L E+++ T + E+L+ ++ DS + + L + +
Sbjct: 2305 LLDDWA-------SKGTLVEEINCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVG 2354
Query: 1791 -LQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL--LNDQCKNF 1847
+ H+ L +I C ++S++ +YE + + + ++ LQ +++ ++ + +
Sbjct: 2355 SVNGYHTCKDL-TEIQC---DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2410
Query: 1848 NDWFSNIKVNLKECFESSETKKSVEQKLQKLSD--FLT-LEGRNSKIKQVDSVLKHVKKH 1904
W + + LK S K+ K Q S+ FL LE + KI++V L +
Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2470
Query: 1905 LPKAHVKELISWLVGQEFEL----EKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLT 1960
P + E +W QE EL E+ + AR ++LE+S L Q LR WL
Sbjct: 2471 YPNSQEAE--NWKKIQE-ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527
Query: 1961 NQEEKWKGMEEP-----------GEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEE 2009
++E G+ P ++ + + +R+Q E QLN + + T
Sbjct: 2528 -EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE---QLNEAAQGI-LTGPG 2582
Query: 2010 EIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQ---------SFNDLAHDVIHWIKEI 2060
++ + + + Q++ ++ +E DKL Q + +L D+ ++ +
Sbjct: 2583 DVSLSTSQVQKELQSINQKW--VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640
Query: 2061 KESLMVLN---------------SSEGKMPLEERIQKIKEIILLKPEGDARI-ETIMKQA 2104
+ L V + +SE + LE+ ++KE L E I E +K
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 2700
Query: 2105 ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKK 2164
++K L ++ LA+ ++ + L +++ Q ++LR L + + +
Sbjct: 2701 -------LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 2753
Query: 2165 QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECT---KNPSFSEE 2221
Q + L+ ++QL+ ++F K + + + ++G LL + +
Sbjct: 2754 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 2813
Query: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVD 2281
+E+K+ E L ++ D L +++ YQ V DL +++ K +S +D
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED-CKAKMSELRVTLD 2872
Query: 2282 QIAVEEKLQK----LQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD------ 2331
+ +E L + L E+E R SL + IL A + N+S + I+D+
Sbjct: 2873 PVQLESSLLRSKAMLNEVEKRRSLLE-----ILNSAADILINSSEADEDGIRDEKAGINQ 2927
Query: 2332 ----------------------IKSLQCKQKDLENRLASAKQEME--------CCLNSIL 2361
++ Q K++E ++ AK ++E C N L
Sbjct: 2928 NMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL 2987
Query: 2362 KSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQL 2419
+ R+ ++ + P + + T + E + + +L E+ + +E+ KQ
Sbjct: 2988 EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV---KQR 3044
Query: 2420 SLNAQESMKNT-----EDERKVNELQNQPLELDTML------------RNEQLEEIEKLY 2462
+ M+N + +V E+ +Q +LD L Q+E++
Sbjct: 3045 VNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFL 3104
Query: 2463 TQLEAKKAAIKPLEQTECLNK-TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
++ K I+ E EC + E G L L + + L+ L K ++ Q +
Sbjct: 3105 NKIHVLKLDIEASE-AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLEL 3163
Query: 2522 ----LRDFQEYLAAVESSMKALLTDKESLK--VGPLDSVTYLDKIKKFIASIEK-EKDSL 2574
+ DF L + + A + E+L+ VG T ++ I + +A + +K+ +
Sbjct: 3164 TLGRVEDFYRKLKGLNDATTA-AEEAEALQWVVG-----TEVEIINQQLADFKMFQKEQV 3217
Query: 2575 GNLKIKWENLSNHVTDMDKKLLES-----QIKQLEHGWEQVEQQ---IQKKYSQQVVEYD 2626
L++K + V + + L++S ++ LEH E++ + + KK +Q++ +
Sbjct: 3218 DPLQMKLQ----QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3273
Query: 2627 EFTTLMNKVQDT---EISLQQQQQHLQLRLKSPEE-----RAGNQSMIALTTDLQATKHG 2678
E K QD +S + L K P +A Q L L K
Sbjct: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333
Query: 2679 FSVLKGQ-AELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMK 2737
+L+ + + ++EK + + +L+ +W L + K R K
Sbjct: 3334 VDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTEL----------LSKAAARQKQL 3381
Query: 2738 ETIL-WAKNLLGELNPSIPLL---------PDDILSQIRKCKVTHDGILARQQSVESLAE 2787
E IL AK P L + + +Q K + A ++ +E+ A
Sbjct: 3382 EDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHAT 3441
Query: 2788 EVKDKV------PSLTT-YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
+V V SLT+ E L+ ++ L+ +Y + + +++ L+ L F
Sbjct: 3442 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 3501
Query: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
+ + E E + + L H A +E+ + ++
Sbjct: 3502 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 3561
Query: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEAD 2960
+ ++ E L ++++L +K R I T ++ ++ RQ K + EE
Sbjct: 3562 LLKQTTGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLATKFQSTYEELT 3617
Query: 2961 SIQR--NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIG--------- 3009
R E L E+I + R +K +V++ + V D +
Sbjct: 3618 GWLREVEEELATSGGQSPTGEQIPQFQQRQKELK---KEVMEHRLVLDTVNEVSRALLEL 3674
Query: 3010 LNWDFSQ-LDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEV 3068
+ W + LD+L + E+ K + + I Q +E Q +A D ++ + E
Sbjct: 3675 VPWRAREGLDKLVSDANEQYKLVSDTIGQ--RVDEIDAAIQRSQQYEQAADAELAWVAET 3732
Query: 3069 VLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAE 3128
K P RL + +++ K +II+ + D+ F + + E
Sbjct: 3733 KRKLMALGP--IRLEQDQTTAQLQVQKAFSIDIIR---HKDSMDELFSHRSEIFGTCGEE 3787
Query: 3129 ENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQ-----------------IKSQ 3171
+ L + ++++ + L +LE + ++NQ + +Q
Sbjct: 3788 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ 3847
Query: 3172 LQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQ-REENSSEASDVETKL 3230
L P ++ + ++ +++ +E + I + I Q +E N E VE K
Sbjct: 3848 LPSPA---IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY 3904
Query: 3231 REFEDLQMQLNTSIDLRTNVLNDAYE---NLTRYKEAVTRAVESITSLEA-----IIIPY 3282
++ E++ Q+ + R L++A +T + + + +E++ +L + +IP
Sbjct: 3905 QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA 3964
Query: 3283 RVD------VGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQEL 3336
VD N ++E+ E+L+ + ++ E+L S K +Q+
Sbjct: 3965 EVDKIRECISDNKSATVEL-----EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019
Query: 3337 VSKNSAMKEAFKAQETEAE-RYLENYKCYRKMEEDIYTNLSKMETV--LGQSMSSLPLSY 3393
+ + E KA+ E E ++L+ + K D+ L+ ++ + + S +
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
Query: 3394 REALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSL 3453
+++E ++ + EEL +R + L C E + + K + + W +L
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4139
Query: 3454 LEAAKEWEMWCEELKQEWKFVSEEIEREAIILDN-----------------LQEELPEIS 3496
+ KE E+ Q + ++ LDN ++++L E+
Sbjct: 4140 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMK 4199
Query: 3497 KTK-----EAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPES------- 3544
+ K + E+L+ + + + + + ++ L + +N+ E
Sbjct: 4200 EFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHK 4259
Query: 3545 -SGAVETVPAFQ----EITSMKERCNKLL---QKVQKNKELVQTEIQERHSFTKEIIALK 3596
GA+ + FQ E+ S +LL + + + ++++ E+ + H +++A
Sbjct: 4260 LEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA-- 4317
Query: 3597 NFFQQTTTSFQNMAFQDHPEKS--EQFEELQSILKKGKLTFENIMEKLRIKYSEMY-TIV 3653
Q T N A + E S + L+S L+ +E++++K + ++ T+
Sbjct: 4318 ---HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQ 4374
Query: 3654 PAE-IESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
A+ S++E+ L ++ ++S R +++ ++E Q K+K
Sbjct: 4375 QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT------HMELYSQLKAK- 4427
Query: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
+E ++ D+ + + D G + ++ + Q++ VS +
Sbjct: 4428 ----EETYNQLLDK------------GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4471
Query: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALE 3832
E R S+L +A E+ + L+ W+ L N A SL +TV +E
Sbjct: 4472 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSL-----ILNTVLSQIE 4525
Query: 3833 DSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDV 3892
+ H +F + + D++ + + + NQ+ L QK DV
Sbjct: 4526 E--------HKVFAN----EVNAHRDQIIE-LDQTGNQLKFLSQK------------QDV 4560
Query: 3893 VAIESEVKSMEKRVSKI 3909
V I++ + S++ R K+
Sbjct: 4561 VLIKNLLVSVQSRWEKV 4577
Score = 122 bits (305), Expect = 2e-26
Identities = 555/3237 (17%), Positives = 1235/3237 (38%), Gaps = 420/3237 (12%)
Query: 396 EAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHL 455
+AW+Q E +++ LS + V +QE++ K L + H
Sbjct: 1945 QAWMQACEANVEKLLSDTVASDPGV--LQEQLATTKQLQEELAEHQ-------------- 1988
Query: 456 PLVPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV 515
VP KL+++ R I I + H + V D + S ++ Y E
Sbjct: 1989 --VPVEKLQKVARDIMEIEGEP----APDHRH---VQETTDSILSHFQ--SLSYSLAERS 2037
Query: 516 ELLLEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCM------ 569
LL + + + L++ Q GE+ +NL G KQ + S V
Sbjct: 2038 SLLQK---AIAQSQSVQESLESLLQSIGEVEQNLEG------KQVSSLSSGVIQEALATN 2088
Query: 570 --YRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHAT 627
+++I KS+L+ ++E A + K E+ + + Q + ++
Sbjct: 2089 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2148
Query: 628 LNEAGNFLVEVSNDVVGSSISKELRR-LNKRWRKLVSKTQLEMNLP---LMIKKQDQPTF 683
L + + + +S +L++ + + R L S Q + ++ I++ +
Sbjct: 2149 LKKL------LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEME 2202
Query: 684 DNSGNILSKEEKATVEFSTDMSVELPENYN--QNIKAG----EKHEKENEEFTGQLKVAK 737
D N+ + E T S +++L ++ + QN++ +K KE E+ +
Sbjct: 2203 DQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQL 2262
Query: 738 D-VEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQ 796
D KL+ + W E + + + S +E K + S+ D+ ++ + +++ +
Sbjct: 2263 DEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCK 2322
Query: 797 NISSQESFQHVLTTGLQAKIQEAKEKVQINV--VKLIAALKNLTDVSPDL-DIRLKMEES 853
S + + Q K V +V V K+LT++ D+ D+ LK E+
Sbjct: 2323 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKL 2382
Query: 854 QKELESYMMRAQQLLGQRESPGELISKHKEA-LIISNTKSLAKYLKAVEELKNNVTEDIK 912
L Q +L + E HKEA ++ +S + LK+++ + + +
Sbjct: 2383 GGVLHERQESLQAILNRMEEV------HKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2436
Query: 913 MSLEEKSRDVCAKWESLHHELSLYVQQLK---IDIEKGKLSDNILKLEKQINKE-----K 964
+ E ++ A+ E ++ + L + + ++N K+++++N +
Sbjct: 2437 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2496
Query: 965 KLIRRGRTKGLIKEHEACFSEEGC-----LYQLNHHMEVLRELCEELPSQKSQ-QEVKRL 1018
+ R R H ACF L + M VL L + +Q Q+V+ +
Sbjct: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 2556
Query: 1019 LKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
LK++E + ++ H L A G G ++ S ++ + + Q
Sbjct: 2557 LKEFEARRQQ--------HEQLNEAAQGILTGPGDVSLSTSQ----------VQKELQSI 2598
Query: 1079 TEKAMEPTMKFSLAS------VLRPLQEESIMEKDYSASINSLLERYDTYRDI-LEHHLQ 1131
+K +E T K + S +++ Q + +++ D S + ++ +R I +
Sbjct: 2599 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ-DLSEKVRAVGQRLSVQSAISTQPEAV 2657
Query: 1132 NNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPF 1191
+ TS+ S+ ++ L ++ + Q + +E E + + +L+ + + P
Sbjct: 2658 KQQLEETSEIRSDLEQ----LDHEVKEAQTLCDELSVLIGE-QYLKDELKKRLETVALPL 2712
Query: 1192 VIKERDTLKERERELQMTLNT--RMESLETALRLVLPVEKASLLL-CGSDLPLHKMAIQG 1248
E D +R LQ L + + + + LR L +++ C L ++ Q
Sbjct: 2713 QGLE-DLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ- 2770
Query: 1249 FHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFD-LHAMQNIILKYKTQ 1307
Q Q S+ + + G +L + P + +QN +++ K
Sbjct: 2771 ---------LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNH 2821
Query: 1308 FEGMNHR-----------VQRS-------EDTLKALEDFLASLRTAKLSAEPVTDLSASD 1349
+E ++ + +Q++ ED + +ED A + +++ +PV S+
Sbjct: 2822 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 2881
Query: 1350 TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK 1409
A N V+ + + ++ A L + + +D + G + + + + + K
Sbjct: 2882 RSKAMLNE--VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 2939
Query: 1410 LSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
G EE T+ + + FKN E K ++ + Q+ + K+ +K
Sbjct: 2940 T------GSLEEMTQRLREFQES-FKNIE--KKVEGAKHQLEIFDALGSQACSNKNLEK- 2989
Query: 1470 LIRLDKVLDEYEEEKRHLQEMANSLPH-FKDGREKT-VNQQCQNTVVLWENTKALVTECL 1527
L +VL E + +L+ L DG + + + Q + + K V
Sbjct: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3049
Query: 1528 EQCGRVLELLKQYQ-NFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE 1586
LE + Q+ + + + L ++ + + A ++L+ +I ++ + + +
Sbjct: 3050 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3109
Query: 1587 HLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALA 1646
++ C+++ L + T + ++E + + + E+ + E L L
Sbjct: 3110 LKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3166
Query: 1647 LWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL----QVHEQKTSEFSRRVAE 1702
+ + +++ T A + L + + E + ++L +++ ++ +
Sbjct: 3167 RVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3226
Query: 1703 I----QFLLQSSEIPLELQVMESSI---------LNKMEHVQKCLTGESNCHALSGSTAE 1749
+ Q L+QS+ ++Q +E + LNK + E+ H +
Sbjct: 3227 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC-----GK 3281
Query: 1750 LREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQ-----KHSMILLENQI 1804
++ L+ + + TE L+ P + K + +Q++LQ+ K ++ +L+ +
Sbjct: 3282 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3341
Query: 1805 GCL------------TPELSELKKQYESVSDLFNTKKSVLQDHF--SKLLNDQCKNFNDW 1850
G + T +L L+ ++ + ++ L+D +K ++ + +D+
Sbjct: 3342 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3401
Query: 1851 FSNIKVNLKECFE-SSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAH 1909
S + L ++T K +Q ++ + +E + + Q + + + A
Sbjct: 3402 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3461
Query: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
L + + +++ C +A L+ +L +D + WL E+K +
Sbjct: 3462 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 3521
Query: 1970 EEPGEKTELF----CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTL 2025
K ++ LA E ++ ++K ++ E + ++ +
Sbjct: 3522 FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 3581
Query: 2026 LRQLSEIE-EEDKLLPTEDQS------FNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
+ ++I K L T +Q+ F ++ W++E++E L +S G+ P E
Sbjct: 3582 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGE 3638
Query: 2079 RI----QKIKEIILLKPEGDARIETIMKQAESSEAPL----------VQKTLTDISNQWD 2124
+I Q+ KE+ E ++T+ E S A L + K ++D + Q+
Sbjct: 3639 QIPQFQQRQKELKKEVMEHRLVLDTVN---EVSRALLELVPWRAREGLDKLVSDANEQYK 3695
Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKI 2184
+ + + ++Y Q+ + + E K+K A ++ + AQL++
Sbjct: 3696 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 3755
Query: 2185 YKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD-SVQN 2243
K F + EL S + + + EE ++ ESL+QQ + S+ N
Sbjct: 3756 QKAFSIDIIRHKDSMDELFSHRSEIFG-----TCGEEQKTVLQEKTESLIQQYEAISLLN 3810
Query: 2244 LDGHVREHDSYQVCVTDLNTTLDNFS------KEFVSFSDKP-VDQIAVEEKLQKLQELE 2296
+ + R + QV V T + S + ++ P +D + ++ +++++L
Sbjct: 3811 SERYARLERA-QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 3869
Query: 2297 NRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEME-- 2354
++ + K+L + +K+ G+ + + K + EN A K+E+
Sbjct: 3870 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE--------KYQKAENMYAQIKEEVRQR 3921
Query: 2355 --CCLNSILKSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
++ +S + TE K P E + +S ++ A V+K+ E NK +
Sbjct: 3922 ALALDEAVSQSTQITEFHDKIE-PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSAT 3980
Query: 2411 VEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK-- 2468
VE+ + + E++K +E + Q +L ++L+++ + ++A+
Sbjct: 3981 VELEKLQP----SFEALKRRGEEL-IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4035
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ IK L+ E K L Q + + L++ +++ E
Sbjct: 4036 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-------PGIDPSIIKQQVEA 4088
Query: 2529 LAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHV 2588
++ L + E +++ D + + +K + K D + N WENL+
Sbjct: 4089 AETIKEETDGLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNNA---WENLNKTW 4143
Query: 2589 TDMDKKLLESQIKQLEHG------WEQVEQQIQKKYSQQVVEYDEFTTL--MNKVQDTEI 2640
+ +KL ++ +++ ++ ++ + K + V D T +N++++ ++
Sbjct: 4144 KERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV 4203
Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
+ QQQ ++ L Q EL +K+ E ++
Sbjct: 4204 EVYQQQIEMEK------------------------------LNHQGELMLKKATDETDRD 4233
Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKC-----DIRNKMKETILWAKNLLGELNPSIP 2755
+ + + LK WE L +++++ ++ ++E + W + L+ P
Sbjct: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293
Query: 2756 LLPDDILSQIRKCK--VTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRN 2813
+ D + ++ K V + +LA Q +VE++ + + + S + S L + LE +
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353
Query: 2814 QYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAA---TEAEL 2870
++ ++ K+ +R QQL+ L++ F + I F L + E+ + T T E
Sbjct: 4354 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQ 4413
Query: 2871 KHHHVTLEASQKELQEI----------------DSGISTHLQELTNIYEELNVFERLFLE 2914
H+ L + K +E DSG + ++ + E+ +E
Sbjct: 4414 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4473
Query: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSA----LQEEADSIQRNELLLN 2970
++ L+ N F QN+ E + + Q S L I+ +++ N
Sbjct: 4474 ERKSKLEEALNLATEF-QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 4532
Query: 2971 QEVNKGVKEEIYNLKDRLTAIKCCILQ--VLKLKKVFDYIGLNWDFSQLDQLQTQVFEKE 3028
EVN +++I L +K + V+ +K + + W+ ++ + E+
Sbjct: 4533 -EVNAH-RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE-----KVVQRSIERG 4585
Query: 3029 KELEEKIKQLDTFEEEHGKYQALLSKMRA--------------IDLQIKKMTEVVLKAPD 3074
+ L++ K+ F E K L + I LQ+ K E
Sbjct: 4586 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 4645
Query: 3075 SSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLY 3134
P + I + R K K L E +KL+ F ++K + E KL
Sbjct: 4646 KQPV---YDTTIRTGRALKEKTLLPEDSQKLDN---FLGEVRDKWDTVCGKSVERQHKLE 4699
Query: 3135 KVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEA 3194
+ L L D L+ + L +++ QL + ++ ++ + N D +
Sbjct: 4700 EAL-----------LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
Query: 3195 FQEQVWAEMCSIKAVTAIEKQREENS-SEASDVETKLREFE---DLQMQLNTSIDLRTNV 3250
FQ+++ +++ + ++ ENS + + V+ +L+E D +L+ S R
Sbjct: 4749 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR--- 4805
Query: 3251 LNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP-------LRKQEEL 3303
L A + +++ V +E ++ E + +R + + E+L+ ++K EE
Sbjct: 4806 LEQALKQAEVFRDTVHMLLEWLSEAEQ-TLRFRGALPDDTEALQSLIDTHKEFMKKVEEK 4864
Query: 3304 ESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC 3363
V + E + + P+ +++ + + ++ + K + E L
Sbjct: 4865 RVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 4924
Query: 3364 YRKMEEDIYTNLSKMETVLGQ-SMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
++ E++ + ET L Q +P + +++ KAL++ + EE+ +
Sbjct: 4925 NAELLEELLAWIQWAETTLIQRDQEPIP-------QNIDRVKALIAEHQTFMEEMTR 4974
Score = 108 bits (269), Expect = 2e-22
Identities = 158/821 (19%), Positives = 326/821 (39%), Gaps = 59/821 (7%)
Query: 4667 SVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYA--------LLQEVYKLEDVLDS 4718
+V +QL + + VE+ + + KL +GE L L A + + + +L+ + ++
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE-LMLKKATDETDRDIIREPLTELKHLWEN 4248
Query: 4719 MWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIEN 4778
+ + R +L + Q L+ ++ + +E L KV ++ ++
Sbjct: 4249 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV-IEVELAK 4307
Query: 4779 HKVFFQKLVADMLLIQAYS--------------AKILPSLLQNRETFWAEQVTEVKILEE 4824
H V ++A ++ + A L S L+ W + + EE
Sbjct: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT---EE 4364
Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQI 4884
+ +Q LQ E ++ L + L ++ P+ L E E+L + Y Q+
Sbjct: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4424
Query: 4885 KRNIGGKHARLYQTLNEGKQLVA----SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
K K Q L++G+ ++ S S + E +A LE++W ++ K++ +L+
Sbjct: 4425 K----AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4480
Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
L + + WL ++ +LN SL L+T+ S I F+ EV+
Sbjct: 4481 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL----ILNTVLSQIEEHKVFANEVNA 4536
Query: 5001 KSSLKTAVISIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
+ GNQL L ++ D ++ L + +W ++ + + L +
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596
Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF-- 5117
+A ++I W+ + E E + + ++K L KHKEF+ + KQ + D
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 4654
Query: 5118 -VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
++L + + +S++ + LGE+ +W V G + LE+ L +
Sbjct: 4655 RTGRALKEKTLLPEDSQKLD-----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 4709
Query: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDI-ENQLAIKSKALDELKQSYLT 5235
+ +Q L +WL E +L Q + + L+D + + +L ++ + LK+S
Sbjct: 4710 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRE 4769
Query: 5236 LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIR 5295
L + D + + Q+ S+ V +L S QS L++ +++ + M +
Sbjct: 4770 LIENS----RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825
Query: 5296 FWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEII 5355
+ + ++ + L E LQSL D + E+ + + + + +
Sbjct: 4826 W---LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 4882
Query: 5356 EEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS 5415
C T K W + +A +++ Q + + A A L ++ + Q A +
Sbjct: 4883 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 4942
Query: 5416 MSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
+ + E +P + +K L + Q E + +DR+
Sbjct: 4943 LIQRD-QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
Score = 104 bits (260), Expect = 3e-21
Identities = 616/3464 (17%), Positives = 1308/3464 (37%), Gaps = 549/3464 (15%)
Query: 605 TKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLV-- 662
TKKE++ E +T + +H G+ L E IS++L LNK + L
Sbjct: 1476 TKKEQVSEA-IKTSQIFLAKH------GHKLSEKEK----KQISEQLNALNKAYHDLCDG 1524
Query: 663 SKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKH 722
S QL+ + + +Q T N ++ + + L AG +
Sbjct: 1525 SANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERAL---------AGHQG 1575
Query: 723 EKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKG--SMF 780
++ + K D++ L ++ +V+ D++ MEE+ L + ++
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVK--DIEGFMEENQTKLSPRELTALR 1633
Query: 781 DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI--NVVKLIAALKNLT 838
++L E + + +Q+ + +T+ LQ + +++K ++ N K+ A L +T
Sbjct: 1634 EKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVT 1693
Query: 839 DVSPDLDIRLKMEESQKELESYMMRAQQL------LGQRESPGELI-------SKHKEAL 885
V L ++L + L +G ++P +L ++H+E L
Sbjct: 1694 SVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELL 1753
Query: 886 -----IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES--LHHELSL-YV 937
I T+S +L ++ +N+T + + L++K ++ ++ + E L V
Sbjct: 1754 SQQQNFILATQSAQAFL---DQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810
Query: 938 QQLKIDIEKGKLSDN------ILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEE----- 986
Q L+ +++K L D+ + + EK++ K T + + + FSE+
Sbjct: 1811 QTLQDELQKF-LQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
Query: 987 GCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG 1046
G L + + + ++ K E+ L+KD LK A+E + L
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK-------LKDATERYTALHSKCTR 1922
Query: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDN--QPSTEKAMEPTMKFSLASVLRPLQEESIM 1104
+ + G H A S + E +E + ++AS LQE+
Sbjct: 1923 LGSHLNMLL------GQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 1976
Query: 1105 EKDYSASINSLLERYDTYRDILEHHLQNNKF-RITSDFSSEEDRSSSCLQAKLTDLQVIK 1163
K ++ EH + K ++ D E + D + ++
Sbjct: 1977 TKQLQ-------------EELAEHQVPVEKLQKVARDIMEIEGEPAP-------DHRHVQ 2016
Query: 1164 NETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRL 1223
TD+ F+ +S L ER +L ++ ++ ESLE+ L+
Sbjct: 2017 ETTDSILSHFQSLSYSLA-------------ERSSLLQKAIAQSQSVQ---ESLESLLQS 2060
Query: 1224 VLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGN 1283
+ VE+ L G + + L ++ Q + + S+ E+ R E +
Sbjct: 2061 IGEVEQN---LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETAD 2117
Query: 1284 FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKAL--------------EDFL 1329
+ +Q + + +FE + + Q E +LK L + F+
Sbjct: 2118 STTAAV-------LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2170
Query: 1330 ASLRTAKLSA-EPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSF 1388
+ S +P D++ Q+ QE L +++++ + ++ L C LD+
Sbjct: 2171 ENKSRMLASGNQPDQDITHFFQQI-QELNLEMEDQQENLDTLEHLVTELSSCGFALDL-- 2227
Query: 1389 KDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQS 1448
C++ +++ T +Q+ E K +C + +E K ++ Q
Sbjct: 2228 ----------CQHQDRVQNLRKDFTE---LQKTVKEREKDASSCQEQLDEFRKLVRTFQK 2274
Query: 1449 QISKIGLKDP---TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTV 1505
+ + P T + K +K + L +LD++ + ++E+
Sbjct: 2275 WLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEI------------NCK 2322
Query: 1506 NQQCQNTV--VLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQAS 1563
+N + + +++ L G + + Y K + T IQ + S ++L+
Sbjct: 2323 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL--TEIQCDMSDVNLKYE 2380
Query: 1564 YMG------KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFE 1617
+G +E+L+ + +E V +E N L+ ++ +V K++ + KT E +
Sbjct: 2381 KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKT-ETVKAQ 2439
Query: 1618 KEANIIVDRWLDINE-KTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTE 1676
E+N L+ N K + E L L + +N W K +Q+ EL+ E
Sbjct: 2440 AESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAEN----W--KKIQE-ELNSRWE 2492
Query: 1677 EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTG 1736
R E +++ E + +A Q++E L +ME ++
Sbjct: 2493 ----RATEVTVARQRQLEESASHLA----CFQAAESQLRPWLMEKELM------------ 2532
Query: 1737 ESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHS 1796
G L D + Q + +LK +L E Q IL
Sbjct: 2533 -------MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQH--EQLNEAAQGILTGPGD 2583
Query: 1797 MILLENQIGCLTPELSELKKQYESVSDLFNTKKS------VLQDHFSKLLNDQCKNFNDW 1850
+ L +Q+ EL + +++ ++D N++ S V + +LL D +
Sbjct: 2584 VSLSTSQV---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640
Query: 1851 FSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHV 1910
+ V + K+ +E+ + SD LE + ++K+ ++ + + + ++
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEAQTLCDELSVLIGEQYL 2697
Query: 1911 K-ELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
K EL L L+ +E + R L+ +L + Q LR WL +++ +
Sbjct: 2698 KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKN 2757
Query: 1970 EEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQL 2029
K E Q+ ++ E+F+ ++ E E E +++ ++ +TL QL
Sbjct: 2758 CPISAKLERL-QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEK-RTLQNQL 2815
Query: 2030 SEIEE--EDKLLPTED------------QSFNDLAHDVIHWIKEIKESLMVLNSSEGKMP 2075
E++ E+ T D Q + D++ WI++ K + L + +
Sbjct: 2816 VELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQ 2875
Query: 2076 LEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLS 2135
LE + + K ++ + + +E + A+ L+ + D D + +
Sbjct: 2876 LESSLLRSKAMLNEVEKRRSLLEILNSAADI----LINSSEADEDGIRDEKAGINQNMDA 2931
Query: 2136 HQEKLLLEGEKYLQSKE-DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIY--------- 2185
E+L Q+K L M L++ QE+ ++ ++ K QL+I+
Sbjct: 2932 VTEEL--------QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS 2983
Query: 2186 KKFLKKAQDLTSLLKELKSQGNYLLECTKN-----------------PSFSEEPWLEIKH 2228
K L+K + +L+ L+ Q +YL T+ +++ +LE+K
Sbjct: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3043
Query: 2229 LHESLLQQLQDSVQNLDG-HVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEE 2287
S +++ ++ + H R + + + DL+ LD D +++
Sbjct: 3044 RVNSGCVMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAI-------GRDTDSLQS 3095
Query: 2288 KLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLA 2347
+++ ++ N++ + ++ A + + + ++ +K ++++L + L R
Sbjct: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3155
Query: 2348 SAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK 2407
+ ++++E L + R + T E +A V + E + + D+++ +
Sbjct: 3156 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE--IINQQLADFKMFQ 3213
Query: 2408 DSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEA 2467
V+ K +N +Q+ + D +EEI + L
Sbjct: 3214 KEQVDPLQMKLQQVNGLGQ----------GLIQSAGKDCDVQGLEHDMEEINARWNTLN- 3262
Query: 2468 KKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLL------QALITLKKNKESQYCV 2521
KK A + + E L LH G L+ LL + LI +K ++Y V
Sbjct: 3263 KKVAQRIAQLQEAL---------LH-CGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3312
Query: 2522 LR-DFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
++ QE + ++ LL D+++ V L + +A EK L +L+ +
Sbjct: 3313 VKAQIQE-----QKLLQRLLDDRKAT-VDMLQAEGGRIAQSAELADREKITGQLESLESR 3366
Query: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
W L + K+L + + + K++ + +F ++ K
Sbjct: 3367 WTELLSKAAARQKQLEDILV-------------LAKQFHETAEPISDFLSVTEKKLANSE 3413
Query: 2641 SLQQQQQHLQ---LRLKSPEERAGNQSMIALTTDL-QATKHGFSVLKGQAELQMKRIWGE 2696
+ Q +Q +R K+ EE N + TD+ QA K G S + +
Sbjct: 3414 PVGTQTAKIQQQIIRHKALEEDIENHA-----TDVHQAVKIGQS---------LSSLTSP 3459
Query: 2697 KEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKM-----KETILWAKNLLGELN 2751
E+ L + I++L+ ++ ++ + + ++ E + W + +L+
Sbjct: 3460 AEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLS 3519
Query: 2752 PS-IPLLPDDILSQIRKCKVT-HDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLE 2809
+ D+L + + ++ I+ R+++V+ + + + T E + L+
Sbjct: 3520 SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLD 3579
Query: 2810 DLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAE 2869
++ +Y + + S++ + LE + + F + + ++E E + T+ ++
Sbjct: 3580 GIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE----ELATSGGQSP 3635
Query: 2870 LKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLE-------DQLKNLKI 2922
+ QKEL++ + E + + +N R LE + L L
Sbjct: 3636 TGEQIPQFQQRQKELKK-------EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 3688
Query: 2923 RTNRIQRFIQNTC----NEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVK 2978
N + + +T +E++ I+ +Q+ + A +R + L ++
Sbjct: 3689 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP-----IR 3743
Query: 2979 EEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKE-LEEK--- 3034
E +L K + +++ K D + FS ++ E++K L+EK
Sbjct: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDEL-----FSHRSEIFGTCGEEQKTVLQEKTES 3798
Query: 3035 -IKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEK 3093
I+Q + + + A L + + + + + E + E+R L AQ+ S I+
Sbjct: 3799 LIQQYEAISLLNSERYARLERAQVL---VNQFWETYEELSPWIEETRALIAQLPSPAIDH 3855
Query: 3094 AKCLCDEIIKKLNENKTFDDSFKEKE-----ILQI-----KLNAEENDKL---YKVLQNM 3140
+++ ++ E + +S E + +L+I +LN EE + + Y+ +NM
Sbjct: 3856 -----EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM 3910
Query: 3141 VLELSPK------ELDEKNCQ--------DKLETSLHVLNQIKSQLQQPLLINLEIKHIQ 3186
++ + LDE Q DK+E L L + S+L+ P LI E+ I+
Sbjct: 3911 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 3970
Query: 3187 NEKDNCEAFQEQVWAEMCSIK-AVTAIEKQREE--NSSEASDVETKLREFEDLQMQLNTS 3243
C + + E+ ++ + A++++ EE S+ +D + +E +D +L+
Sbjct: 3971 E----CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD---KLDQM 4023
Query: 3244 IDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP------L 3297
+ ++ A E ++ + + A + + A++ + D + LE P +
Sbjct: 4024 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK-DTQDIVHDLESPGIDPSII 4082
Query: 3298 RKQEELESTVAHIQD-LTEKL--------------GMISSPEAKLQLQYTLQELVSKNSA 3342
++Q E T+ D L E+L G PE + + + N
Sbjct: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
Query: 3343 MKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQ 3402
KE + E + ++ + M + + + K+ T M + ++L +
Sbjct: 4143 WKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-----MPPVGTDLNTVKDQLNE 4197
Query: 3403 SKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEM 3462
K + + E+ KL L+ + T+ +++ L E WE
Sbjct: 4198 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE---------PLTELKHLWEN 4248
Query: 3463 WCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVE 3522
E++ ++E + L Q L E+ TEEL + + + +E
Sbjct: 4249 LGEKIAHR----QHKLEGALLALGQFQHALEELMSW--LTHTEELLDAQRPISGDPKVIE 4302
Query: 3523 ----KQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKL-------LQKV 3571
K +L +L +++ V ++ + A + +S++ R + LQK
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362
Query: 3572 QKNKELVQTEIQERHSFTKEI----IALKNFFQQTTTSFQNMAFQDHP-EKSEQFEELQS 3626
++ ++ +Q+ +Q+ F EI + L Q + S + E+ + EL S
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422
Query: 3627 ILKKGKLTFENIMEKLRI------------KYSEMYTIVPAE---IESQVEECRKALEDI 3671
LK + T+ +++K R+ K + ++ + + S++EE + LE
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE-- 4480
Query: 3672 DEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKS------KNIEKAQEIQKKMWD 3725
E L + + + ++E N L E+ L S + E K +
Sbjct: 4481 ------EALNLATEF--QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 4532
Query: 3726 ELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ-QYQQVSQRAECRTSQLNKAT 3784
E++ ++ ELD + Q + NL++ Q ++++V QR+ R L+ A
Sbjct: 4533 EVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 4592
Query: 3785 VKMEEYSDLLKSTEAWIENT-SHL-----LANPADYDSLRTLSH 3822
+ +++ + K W+E+ SHL ++N D L+ H
Sbjct: 4593 KRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH 4636
Score = 103 bits (258), Expect = 5e-21
Identities = 340/1847 (18%), Positives = 726/1847 (39%), Gaps = 248/1847 (13%)
Query: 4654 TSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLE 4713
T+L++ L++ Q A Q + + E E+ + L+ E E+ L + K++
Sbjct: 1630 TALREKLHQAKEQYEALQ---EETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKID 1686
Query: 4714 DVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA----HGHLKQTKSK 4769
+LD W ++S + Q L GM +L EK A G++ ++
Sbjct: 1687 ALLD--W---------VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAP 1735
Query: 4770 VALQAQIENHKVFFQKLVADM--LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSR 4827
L Q E K Q+L++ ++ SA+ + T +Q+ + K+ E K +
Sbjct: 1736 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQ 1795
Query: 4828 QCGM----------------KLQSLLQKWEEFDENYASLEKDLEIL------ISTLPSVS 4865
+LQ LQ +EF+ EK+LE + TLPS+
Sbjct: 1796 YSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLL 1855
Query: 4866 LVEETEERLVERISFYQQIKRNI---GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLE 4922
+ + E + ++ R + G K + + EGK+ S ++ ++
Sbjct: 1856 ---KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE--PSEIGNLVKDKLKDAT 1910
Query: 4923 EQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLD 4982
E++ +L+ K L LL + +D L W+++ + N K S V+ D
Sbjct: 1911 ERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE--ANVEKLLSDTVASDPG 1968
Query: 4983 TIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLL-----------HLKETDTA------T 5025
++ + + +E+ E + + ++ H++ET + +
Sbjct: 1969 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2028
Query: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQL-----QMEKLPSRKAITEMISWMNNVEHQTS 5080
L SLA+ I Q +QE L L ++E+ K ++ + S + T+
Sbjct: 2029 LSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATN 2088
Query: 5081 ---DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESK---- 5133
+D SS + ++ + E D ++LQ +V +
Sbjct: 2089 MKLKQDIARQKSSLEATREMVTRFME----------TADSTTAAVLQGKLAEVSQRFEQL 2138
Query: 5134 ---RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLES-------ITESENKIQILN 5183
+ E+ + L + + G L + +++ ++L S IT +IQ LN
Sbjct: 2139 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN 2198
Query: 5184 NWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELKQSYLTLESGAVP 5242
+E Q+E L TL+ + +S LD CQ + + L++ + L+
Sbjct: 2199 LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR--------VQNLRKDFTELQKTVKE 2250
Query: 5243 LLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEH 5302
+D +S ++L + R V T LK + S+ E +M +EH
Sbjct: 2251 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP---------TETSMSAKELEKQIEH 2301
Query: 5303 SKPVV-------LSLETLRCQVENLQSLQDE--AESSEGSWEKLQEVIGKLKG------L 5347
K ++ +E + C+ +L++L E A S+G + +G G
Sbjct: 2302 LKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHT 2361
Query: 5348 CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAK 5407
C + E I+ + + ++ ++ + ++ + Q++L H EA + L+ E+K
Sbjct: 2362 CKDLTE-IQCDMSDVNLKYEKLGGVLHERQESLQAIL---NRMEEVHKEANSVLQWLESK 2417
Query: 5408 FQQLANI-SMSGNNLAEILPPA-------LQDIKELQHDVQKTKEAFLQNSSVLDRLPQP 5459
+ L ++ +MS E + L ++++ +QK KEA + +L P
Sbjct: 2418 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL---AGLLVTYPNS 2474
Query: 5460 AESSTHMLLPGPLHS-LQRAAYL----EKMLLVKANE---FEFVLSQFKDFGVRLESLKG 5511
E+ + L+S +RA + ++ L A+ F+ SQ + + + E + G
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534
Query: 5512 LIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS---------LKLPLSD 5562
++ + + L+ Q K+ L A Q E LNE + + L S
Sbjct: 2535 VLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQH---EQLNEAAQGILTGPGDVSLSTSQ 2590
Query: 5563 VAVKTLQNMNRQWIRATATALERCSEL-QGIGLNEKFLYCCEKWIQLLEKIEEALKVDVA 5621
V K LQ++N++W+ T R S++ Q I + ++ + + + + + L V A
Sbjct: 2591 VQ-KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA 2649
Query: 5622 -NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI-TEFSKLTD 5679
++ PE ++QQ +E+ + D V ++ L D + +++ E K +
Sbjct: 2650 ISTQPEAVKQQLEE---TSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE 2706
Query: 5680 RWQNAVQGVRQRKGD----VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLY 5735
+QG+ D + + Q F + L +L D A L
Sbjct: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL-DDKQSQQAKNCPISAKLE 2765
Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDL-KTKESVGRRISQLQDSWKDM 5794
+ +S + E + + + + + + GE LLL+ + K ++ ++ +L++ W+++
Sbjct: 2766 RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL 2825
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSE------DPLPELHEDLHNEK 5848
+ A+ + + ++ + + +++L ++ KA+ DP+ +L L K
Sbjct: 2826 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSK 2884
Query: 5849 ELIKELEQ---------SLASWTQNLKE-----LQTMKADLTRHV--LVEDVMVLKEQIE 5892
++ E+E+ S A N E ++ KA + +++ + E++ +E
Sbjct: 2885 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLE 2944
Query: 5893 HLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMI 5952
+ ++ + ++++E + +F+ + C+ NK L+ +E++
Sbjct: 2945 EMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS------NKNLEKLRAQ-QEVL 2997
Query: 5953 EKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-----EIDDKLNKINDRWQHLF 6007
+ L+ ++ + F++ ++ G + +++ A E+ ++N ++
Sbjct: 2998 QALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKL 3056
Query: 6008 DVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ 6067
+ IG +++E F+ + LD + + + R L + ++++ L +
Sbjct: 3057 EGIGQFHCRVREMFSQLADLDDELDGMGA-IGRDTDSLQSQI-------EDVRLFLNKIH 3108
Query: 6068 DLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMER 6127
L+ DIE A C +L + + +++ +L+++ + R
Sbjct: 3109 VLKLDIEASEAE-------CRHMLEEE----GTLDLLGLKRELEALNKQCGKLTERGKAR 3157
Query: 6128 RMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQR-QI 6186
+ ++E T + F D +AE A ++L F+ FQ+ Q+
Sbjct: 3158 QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQV 3217
Query: 6187 HERLTQLELINKQYRRLARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
+L+ +N + L + D L+ + E N RW+ L ++V + +L+
Sbjct: 3218 DPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALL 3277
Query: 6246 QREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI---TLNTNK--I 6300
+F+ E +L WL + + + N + A+ K+ + +Q++ L+ K +
Sbjct: 3278 HCGKFQDALEPLLSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRLLDDRKATV 3334
Query: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
D L G ++ Q +E D I +LE L E+ + + ++L
Sbjct: 3335 DMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3381
Score = 97.4 bits (241), Expect = 4e-19
Identities = 130/690 (18%), Positives = 276/690 (40%), Gaps = 60/690 (8%)
Query: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
G++ + L + + C E R + L++ L + + +EI+ +L + ++ L
Sbjct: 4338 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQL 4397
Query: 4657 QQSLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
S G ++ EQL +L+ E +L D+G + L K E
Sbjct: 4398 SAS-KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQ 4456
Query: 4715 ---VLDSMWGMLRARYTELSSPF------VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
+L+ W ++ ++ E S TE Q LQ + + + ++ L ++
Sbjct: 4457 SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS--LQEFINWLTLAEQSL---NIAS 4511
Query: 4766 TKSKV--ALQAQIENHKVFFQKLVADM--------------LLIQAYSAKILPSLLQNRE 4809
S + + +QIE HKVF ++ A L Q ++ +LL + +
Sbjct: 4512 PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQ 4571
Query: 4810 TFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE 4869
+ W + V ++S + G L ++ ++F E + L LE S L S +
Sbjct: 4572 SRWEKVV-------QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 4624
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE----LEGQIAKLEEQW 4925
+++ ++S +++ ++ +GGK T+ G+ L PE L+ + ++ ++W
Sbjct: 4625 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 4684
Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
++ K H+L+ L + L WL + L + V DLD +
Sbjct: 4685 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL----AEDQPVHGDLDLVM 4740
Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLP 5045
+ ++ F KE+ +++ + G +L+ DT ++ L + +W +
Sbjct: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800
Query: 5046 DIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFR 5105
Q +L Q + R + ++ W++ E ++ P ++ L+ HKEF
Sbjct: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL--PDDTEALQSLIDTHKEFM 4858
Query: 5106 MEMDYKQWIVD-FVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQH 5164
+++ K+ V+ V + L+ C + T + + ++ V + Q
Sbjct: 4859 KKVEEKRVDVNSAVAMGEVILAVCHPDC----ITTIKHWITIIRARFEEVLTWAKQHQQR 4914
Query: 5165 LEQLLESITESENKIQILNNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAI 5221
LE L + + ++ L W++ E L + P+++ V+ L+ + Q ++
Sbjct: 4915 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 4974
Query: 5222 KSKALDELKQSY--LTLESGAVPLLEDTAS 5249
K +D + ++Y +E P +E + S
Sbjct: 4975 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRS 5004
Score = 83.2 bits (204), Expect = 8e-15
Identities = 385/2184 (17%), Positives = 812/2184 (37%), Gaps = 318/2184 (14%)
Query: 286 KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNE--EK 343
KD ++ Q V+D + W+ K K+ +L + + +SLL NE ++
Sbjct: 2837 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKR 2893
Query: 344 KSFLDVLSIKRDL----DELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL 399
+S L++L+ D+ E D+D ++ +A G++ ++A +L A L + L
Sbjct: 2894 RSLLEILNSAADILINSSEADEDGIRDEKA--GINQNMDAVTEELQ-AKTGSLEEMTQRL 2950
Query: 400 QEVEELMDEDLSASQDHSQAVTLIQ------------EKMTLFKSLMDRFEHHSNILLTF 447
+E +E + + + EK+ + ++ E + L F
Sbjct: 2951 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3010
Query: 448 ---------ENKDEN---HLPLVPPNKLEEMKRRINN---ILEKKFILLLEFHYYKCLVL 492
+ D + H V + E+K+R+N+ ++E K + +FH +
Sbjct: 3011 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3070
Query: 493 GLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLAR-LDTSFQKCGEIYKN--- 548
+ ++ +LD +S++ +ED F+ + L ++ S +C + +
Sbjct: 3071 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3130
Query: 549 -----LAGECQNINKQYMMVKS-----------------DVCMYRKNIYNVKSTLQKVLA 586
L E + +NKQ + D K + + + ++ A
Sbjct: 3131 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA 3190
Query: 587 C-WA--TYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVV 643
W T VE + A F+ +KE++ + + L + AG DV
Sbjct: 3191 LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQ 3245
Query: 644 GSSISKELRRLNKRWRKLVSKT-----QLEMNLPLMIKKQD--QPTFD---NSGNILSKE 693
G + ++ +N RW L K QL+ L K QD +P ++ +++ +
Sbjct: 3246 G--LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3303
Query: 694 EKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTG----QLKVAKDVEKLIGQVEIW 749
+ + E+ + + Q + K + + G Q D EK+ GQ+E
Sbjct: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363
Query: 750 EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESF----- 804
E+ +L + + ++ L+ ++ F E D L + + +++ E
Sbjct: 3364 ESRWTELLSKA---AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3420
Query: 805 ----QHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQ---KEL 857
Q + L+ I+ V VK+ +L +LT + + K++ Q E+
Sbjct: 3421 KIQQQIIRHKALEEDIENHATDVH-QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3479
Query: 858 ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
+ R LL Q S L + + ++ +L VE+ ++V +++
Sbjct: 3480 QDRCCRKAALLDQALSNARLFGEDEVEVL--------NWLAEVEDKLSSVF------VKD 3525
Query: 918 KSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIK 977
+DV + + H L+ + K ++++ N L KQ E+ L+ + + G+
Sbjct: 3526 FKQDVLHRQHADHLALNEEIVNRKKNVDQA--IKNGQALLKQTTGEEVLLIQEKLDGIKT 3583
Query: 978 EH-EACFSEEGCLYQLNHHMEV--------------LRELCEELPSQKSQQEVKRLLKDY 1022
+ + + L L ++ LRE+ EEL + Q + +
Sbjct: 3584 RYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 3643
Query: 1023 EQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGG------DPHSEAPFAKS--- 1073
+Q+ + L K E H + T S+ + R G D + +
Sbjct: 3644 QQRQKELKKEVME-HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 3702
Query: 1074 DNQPSTEKAMEPTMKFSLAS---------------VLRPLQEESIMEKDYSASINSLLER 1118
+ A++ + ++ A+ L P++ +E+D + + + +
Sbjct: 3703 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----LEQDQTTAQLQVQKA 3758
Query: 1119 YDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISL 1178
+ DI+ H K + FS + +C + + T V++ +T++ +++E ISL
Sbjct: 3759 FSI--DIIRH-----KDSMDELFSHRSEIFGTCGEEQKT---VLQEKTESLIQQYEAISL 3808
Query: 1179 KLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSD 1238
+ ER ER Q+ +N E+ E L +E+ L+
Sbjct: 3809 -------------LNSERYARLERA---QVLVNQFWETYE---ELSPWIEETRALIAQLP 3849
Query: 1239 LPLHKMAIQGFHLIDADRIYQH---LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLH 1295
P ID +++ Q +R +++SIA+ ++L + G LKEL+P +
Sbjct: 3850 SPA----------IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP-QLKELNPEEGE 3898
Query: 1296 AMQNIILKYKTQFEGMNHRVQRS---------------------EDTLKALEDFLASLRT 1334
++ K + + + V++ E L+ LE+ + LR
Sbjct: 3899 MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRM 3958
Query: 1335 AKLSAEPVTDLSA--SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
L V + SD + A T+ ++ + +K + + L + D E
Sbjct: 3959 PPLIPAEVDKIRECISDNKSA---TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4015
Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEE--FTEENKLLEACIFKNNELLKNIQDVQSQI 1450
D LD + + E F + +L E + LL I+D Q +
Sbjct: 4016 IQDK------LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069
Query: 1451 SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT-VNQQC 1509
+ +K + ++ + + D EE ++ + L EK V +
Sbjct: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
Query: 1510 QNTVVLWENTKALVTECLEQCGRVLELLKQYQN-FKSILTTLIQKEESVISLQASYMGKE 1568
WEN E LE+ ++ QYQ+ +++ L + ++
Sbjct: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4189
Query: 1569 NLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPP---FEKEANIIVD 1625
+K ++ E++ K E + ++K+N Q L K +E + +
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNH-----QGELMLKKATDETDRDIIREPLTELKH 4244
Query: 1626 RWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEE 1685
W ++ EK L AL + + + W + ++ + D + ++ E
Sbjct: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
Query: 1686 LQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME--SSILNKMEHVQKCLTGESNCHAL 1743
L H ++ A ++ + ++ LE + SS+ +++E + +C ES
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW--ESVLQKT 4362
Query: 1744 SGSTAELREDLDQAK----------TQIGMTESLLKALSPSDSL------------EIFT 1781
+L+ L QA+ ++ ES L A P+ L E+++
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422
Query: 1782 KL---EEIQQQILQQKHSMILLENQIGC---LTPELSELKKQYESVSDLFNTKKSVLQD- 1834
+L EE Q+L + M+L + G ++ L++++ VS +KS L++
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4482
Query: 1835 -HFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLT-LEGRNSKIK 1892
+ + + + F +W + + +L S +V ++++ F + +I
Sbjct: 4483 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 4542
Query: 1893 QVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDH 1952
++D +K K V + + LV + EK+ R + L+D+ ++ + +
Sbjct: 4543 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 4602
Query: 1953 RNLRKWLTNQEEKWKGMEEPGE----------KTELFCQALARKREQFESVAQLNNSLKE 2002
+ L WL + E E K + F + L K+ +++ + +LKE
Sbjct: 4603 KKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE 4662
Query: 2003 YGFTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
E+ ++ + D++ T+ + E + + + F D ++ W+ ++
Sbjct: 4663 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 4722
Query: 2061 KESL-----------MVLNSSEGKMPLEERIQKIKEII-LLKPEGDARIETIMKQAESSE 2108
+ L +V+N + ++ + K + +LK G IE +
Sbjct: 4723 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-----SRDD 4777
Query: 2109 APLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
V+ L ++S +WD L+ + S E+ L + E + + L L E ++
Sbjct: 4778 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 4837
Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE-CTKNPSFSEEPWLE-I 2226
AL + ++ + +K+F+KK ++ + + G +L C + + + W+ I
Sbjct: 4838 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 4897
Query: 2227 KHLHESLLQQLQDSVQNLDGHVRE 2250
+ E +L + Q L+ + E
Sbjct: 4898 RARFEEVLTWAKQHQQRLETALSE 4921
Score = 75.5 bits (184), Expect = 2e-12
Identities = 265/1481 (17%), Positives = 564/1481 (38%), Gaps = 291/1481 (19%)
Query: 5094 VKHLLQKHKEFRMEMDYKQWIVDF------------VNQSLLQLSTCDVESKRYE----- 5136
V LL +E +M+++ +W D ++ S+ +L + E++ YE
Sbjct: 589 VYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQ 648
Query: 5137 --RTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILN---------NW 5185
T +AE LG++ Q+ ++ + +++HL+ L + ++ + ++ LN +W
Sbjct: 649 NFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDW 708
Query: 5186 --------------------LEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKA 5225
LE +++ ++LQ ++S++ Q +E A
Sbjct: 709 SDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK-QTVEAYSAAVQSQ 767
Query: 5226 LDELKQSYLTLE-------------SGAVPL------LEDTA------------SRIDEL 5254
L +KQ L +E S A L L+D+ SR+++L
Sbjct: 768 LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL 827
Query: 5255 FQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLY----DEVNMMTIRFWYCMEHSKPVVLSL 5310
Q Q+ Q K+S+ S++ K QL D V TI ++ + +
Sbjct: 828 LQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITIC 887
Query: 5311 ETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVN 5370
+ C +E+ S W+ + + + PSV +I ++ + ++V
Sbjct: 888 KNDECVLED--------NSQRTKWKVISPTGNE--AMVPSVCFLIPPPNKDAIEMASRVE 937
Query: 5371 QAIADQLQKAQSLLQLW-KAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPAL 5429
Q+ Q ++ LW + + N + +++ Q N L ++ A
Sbjct: 938 QSY-------QKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWN-------LEKLRSSAP 983
Query: 5430 QDIKELQHDVQKTKEAFLQNS------SVLDRLPQPAE----SSTHMLLPGPLHSLQRAA 5479
+ ++ ++Q E FLQ+S SV DRL E + L + + +
Sbjct: 984 GECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEE 1043
Query: 5480 YLEKMLLVKANEFEFVLSQFKDFGV-RLESLKGLIMHEE---ENLDRLHQQE--KENPDS 5533
+ KM + + L +++ V R++SL + +N R+ +QE +E+
Sbjct: 1044 TVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQ 1103
Query: 5534 FLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIG 5593
+ + A++ + H + S +P + L + L + + I
Sbjct: 1104 LRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIV 1163
Query: 5594 LNEKFLYCCEKWIQLLEKIEEALKVDVA----------NSLPELLEQQKTYKMLEAEVSI 5643
+ + K ++ EE + D++ + L ++ ++ + +L+ E++
Sbjct: 1164 RSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAK 1223
Query: 5644 NQTIAD--SYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQ 5701
+ +A+ S +T L ++E E + S+L +RW + + R+ +++ +
Sbjct: 1224 AKVVAEQMSRLTPERNL----DLERYQE---KGSQLQERWHRVIAQLEIRQSELESIQEV 1276
Query: 5702 WQDFTTSVENLFRFLTDTSHLLSAVK-GQERFS------LYQTRSLIHELKNKEIH---- 5750
D+ L +++ +T+ +K GQ S L Q +L E++ +
Sbjct: 1277 LGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQC 1336
Query: 5751 -------------FQRRRTTCALTLEAGEK-------LLLTTDLKTKESVGRR------- 5783
++ + T +E+ +K +L ++D T+E + R
Sbjct: 1337 QKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALV 1396
Query: 5784 ------ISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSED 5835
+ + D+ + +E + + ++ Q VE K+KEL + L Q +
Sbjct: 1397 TLTTQHVKYISDALRRLEEEEKVVEEEKQEHVE-------KVKELLGWVSTLARNTQGKA 1449
Query: 5836 PLPELHEDLHNEKELIKE--LEQSLASWTQNLKE-LQTMKADLTRH---VLVEDVMVLKE 5889
E E EK ++++ L + L + + + E ++T + L +H + ++ + E
Sbjct: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISE 1509
Query: 5890 QIEHLHRQWEDLCLRVAIRKQEIEDRLNTWV----------VFNEKNKELCAWLVQMENK 5939
Q+ L++ + DLC A + Q+++ +L +++ ++LC+W+ Q E
Sbjct: 1510 QLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERA 1569
Query: 5940 VLQTADISIEEMIEKLQK------DCMEEI-NLFSENKLQLKQMGDQLIKASNKSRAAEI 5992
+ + ++ + LQK D ++I N + +K + + + K E+
Sbjct: 1570 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 1629
Query: 5993 D---DKLNKINDRWQHLFDVIGSRVKKLKE--TFAFIQQLDKN------------MSNLR 6035
+KL++ ++++ L + K+L+E T A Q+ +K+ + L
Sbjct: 1630 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALL 1689
Query: 6036 TWLARIESE------------------LSKPVVYDVCD------------DQEIQKRLAE 6065
W+ + S L K + D D D++ + A
Sbjct: 1690 DWVTSVGSSGGQLLTNLPGMEQLSGASLEKGAL-DTTDGYMGVNQAPEKLDKQCEMMKAR 1748
Query: 6066 QQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSM 6125
Q+L + +S D H+ E +QQ L ++ A S
Sbjct: 1749 HQELLSQQQNFILATQSAQAFLDQHGHN----LTPEEQQMLQQKLGELKEQYSTSLAQSE 1804
Query: 6126 ERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQ 6185
+++ QKFL D+ FE WL+ +E+ + + LKR +F
Sbjct: 1805 AELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 1864
Query: 6186 IHERLTQLELINKQYRR-LARENR-------TDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
+ L + ++ L EN ++ + +K + + +R+ L + T +
Sbjct: 1865 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 1924
Query: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH-FSESDADDKMRQLNGFQQEITLN 6296
L Q +F+ + +S+ W+ + NVE S++ A D G QE
Sbjct: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACE---ANVEKLLSDTVASDP-----GVLQEQLAT 1976
Query: 6297 TNKIDQLIVFGEQLIQKSEPL--DAVLIEDELEELHRYCQE 6335
T ++ + + + ++K + + D + IE E HR+ QE
Sbjct: 1977 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE 2017
Score = 59.7 bits (143), Expect = 1e-07
Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 32/258 (12%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4302
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ L+ +L Q Q FH ++ LL L +++ + T L E RE +
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG------GLPETAREQLDT 4416
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGH---------------GEDCIEAEEKVHVIEKKLK 6777
EL Q+ +E N LL KG + E+K HV+ K++
Sbjct: 4417 HMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4473
Query: 6778 QLREQVSQDLMALQGTQN 6795
+ + ++ + L QN
Sbjct: 4474 ERKSKLEEALNLATEFQN 4491
Score = 55.1 bits (131), Expect = 2e-06
Identities = 73/336 (21%), Positives = 140/336 (41%), Gaps = 21/336 (6%)
Query: 6547 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 6602
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415
Query: 6603 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3471
Query: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720
L + Q L Q+L + F + +L WLA +++ V D K D
Sbjct: 3472 LQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 3529
Query: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
L + + L +E+V R+ VD + +LL + GE+ + +EK+ I+ + +
Sbjct: 3530 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 3589
Query: 6781 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRV 6840
S+ L L+ + A+ S E +G R + T+ G+ T ++
Sbjct: 3590 VTSSKALRTLEQARQLATKFQSTYEELTG---------WLREVEEELATSGGQSPTGEQI 3640
Query: 6841 PGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6876
P + Q+ V+ L L + + L L+P
Sbjct: 3641 PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 3676
Score = 51.2 bits (121), Expect = 3e-05
Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 8/234 (3%)
Query: 6574 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 6631
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772
Query: 6632 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6691
L + S+ F + T LQ + L +EA L ++ + F +
Sbjct: 3773 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE 3829
Query: 6692 LSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISN 6751
+ L W+ + R A + P D L + + E+ QL + + E +P +D L +I
Sbjct: 3830 TYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887
Query: 6752 SLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDE 6805
L + + E+ EEK E Q++E+V Q +AL + ++ + F +
Sbjct: 3888 QLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 3940
Score = 50.8 bits (120), Expect = 5e-05
Identities = 45/199 (22%), Positives = 85/199 (42%), Gaps = 11/199 (5%)
Query: 6565 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 6624
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 1806 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 1863
Query: 6625 AFDTYKALVVSVNVSSKEFLQTESP-----ESTEL----QSRLRQLSLLWEAAQGAVDSW 6675
++K + V +S ++ L E+ E +E+ + +L+ + + A
Sbjct: 1864 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 1923
Query: 6676 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKE 6735
L L Q F + +L W+ + + +K +DP L E QL++E
Sbjct: 1924 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 1983
Query: 6736 LVERQPQVDMLQEISNSLL 6754
L E Q V+ LQ+++ ++
Sbjct: 1984 LAEHQVPVEKLQKVARDIM 2002
Score = 50.8 bits (120), Expect = 5e-05
Identities = 48/216 (22%), Positives = 94/216 (43%), Gaps = 18/216 (8%)
Query: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
D+W+ + + + + K+++ L Q + A+ WL K E +L + D+
Sbjct: 4682 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDL--- 4738
Query: 6613 ELRVKRLQEILKAFDTY----KALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 6668
V L + K F V + S +E ++ ++T ++ +L++LS W+
Sbjct: 4739 ---VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 4795
Query: 6669 QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRR 6727
S + L Q+L Q + F LL WL+ A+ R + + D ++L++ +
Sbjct: 4796 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 4855
Query: 6728 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6763
E M K++ E++ V+ + +L H DCI
Sbjct: 4856 EFM---KKVEEKRVDVNSAVAMGEVILAVCH-PDCI 4887
Score = 44.7 bits (104), Expect = 0.003
Identities = 43/238 (18%), Positives = 100/238 (42%), Gaps = 14/238 (5%)
Query: 6559 EMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR 6618
E + A ++ + QQ + TWL +++ K + ++ ++ +++
Sbjct: 2716 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ--QAKNCPISAKLERLQSQLQE 2773
Query: 6619 LQEILKAFDTYKALVVSVNVSSKEFLQTESP--ESTELQSRLRQLSLLWEAAQGAVDSWR 6676
+E K+ + + + + L + P E LQ++L +L WE +
Sbjct: 2774 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQ 2833
Query: 6677 GGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT-DPKADPRALLECRRELMQLEKE 6735
L+ + + Q + ++L+ W+ K + + VT DP +LL + L ++EK
Sbjct: 2834 SRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK- 2892
Query: 6736 LVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGT 6793
R+ +++L ++ L+ ++ +EK + Q + V+++L A G+
Sbjct: 2893 ---RRSLLEILNSAADILINSSEADEDGIRDEKAGI-----NQNMDAVTEELQAKTGS 2942
Score = 41.6 bits (96), Expect = 0.028
Identities = 63/323 (19%), Positives = 125/323 (38%), Gaps = 52/323 (16%)
Query: 6560 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 6619
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 3124 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3178
Query: 6620 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLL-------- 6664
+ A + +AL V +N +F + + LQ +L+Q++ L
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3238
Query: 6665 -------------------WEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
W V L+++L+ C F + LL WLA +
Sbjct: 3239 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE- 3297
Query: 6706 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 6765
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 3298 -ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3356
Query: 6766 EEKVHVIEKKLKQL------REQVSQDLMAL----QGTQNPASPLPSFDEVDSGDQPPAT 6815
++ +E + +L R++ +D++ L T P S S E + P
Sbjct: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
Query: 6816 SVPAPRAKFRAVRTTEGEEETES 6838
+ A + + + +R EE+ E+
Sbjct: 3417 TQTA-KIQQQIIRHKALEEDIEN 3438
Score = 38.1 bits (87), Expect = 0.31
Identities = 45/255 (17%), Positives = 97/255 (38%), Gaps = 13/255 (5%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 6614
WE + K++ +Q Q + A+ WL T +++ M +D+ ++
Sbjct: 4136 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV--IKLCTMPPVGTDLNTVKD 4193
Query: 6615 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAV 6672
++ ++E + + +N + L+ + E+ ++ L +L LWE +
Sbjct: 4194 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4253
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ L +L+ F + L+ WL + DP+ + + L
Sbjct: 4254 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI--SGDPKVIEVELAKHHVL 4311
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI----EKKLKQLREQVSQDLM 6788
+ +++ Q V+ + + N LL G+D ++ + E L++ E+ Q
Sbjct: 4312 KNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4371
Query: 6789 ALQGTQNPASPLPSF 6803
LQ Q S + F
Sbjct: 4372 TLQQAQGFHSEIEDF 4386
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 206 bits (524), Expect = 6e-52
Identities = 133/371 (35%), Positives = 193/371 (52%), Gaps = 44/371 (11%)
Query: 24 SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDK 83
SL+ E++ QKK FT W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+K
Sbjct: 13 SLKDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREK 70
Query: 84 GSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQT 143
G F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 71 GRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI------ 124
Query: 144 LSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNV 203
D+ V S M+A++ LLLW+Q Y+ +
Sbjct: 125 ----------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRC 158
Query: 204 TDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPED 263
+F SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PED
Sbjct: 159 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 218
Query: 264 VDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEND 323
VDV PDEKSI+TYV+ P + + + + W ++ L L +
Sbjct: 219 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHT 277
Query: 324 TYFKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKI 382
F++ F SF E + + L K +L + D + + + L+ + A ++
Sbjct: 278 AAFEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQL 333
Query: 383 KLNYALPPPLH 393
K +PP H
Sbjct: 334 K----VPPGYH 340
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1087 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1146
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1147 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1206
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1207 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1261
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1305
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1360
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1361 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1417
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1473
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1474 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1648 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1681
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1682 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1720
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1781 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1827
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1828 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1945
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2005
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 2006 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2064
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2065 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2123 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2176 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2212
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2213 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2256
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2316
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2317 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2488
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2489 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2530
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2590
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2591 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2650
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2651 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2699
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 581 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 640
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 641 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 697
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 698 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 758 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 814
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 815 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 874
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 875 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 919
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 920 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 968
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 969 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1024
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1025 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1077
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1078 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1124
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1125 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1174
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1175 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1212
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1272
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1273 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1320
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1381 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1430 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1471
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1472 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1520
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1521 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1616
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1617 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1721
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1837
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1889
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 1890 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2008
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 2009 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2187 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2364 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2423 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2536
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2654
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2655 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2712
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2713 ASGFLLDPVRNRRLTVNEAVK 2733
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 913 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 971
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 972 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1026
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1027 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1086
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1087 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1145
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1146 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1205
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1206 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1257
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1258 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1317
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1376
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1492
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1493 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1543
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1544 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1655
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1656 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1710
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1711 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1767
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1768 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1823 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2055 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2109
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2110 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2155
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2213 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2267
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2268 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2319
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2320 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2368
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2546 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2604 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2658
Query: 3736 EL 3737
EL
Sbjct: 2659 EL 2660
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 247 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 306
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 307 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 365
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 366 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 425
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 426 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 485
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 486 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 535
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 536 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 581
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 582 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 637
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 638 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 689
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 690 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 742
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 743 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 796 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 856 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 916 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 967
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 968 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1027
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1028 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1076
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1196
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1197 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1317 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1369
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1370 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1407
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1583
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1584 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1637
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1689
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1690 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1747 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1805
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1806 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1922
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 1969
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2024
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2144
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2145 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2203
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2262
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQ 2282
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 933 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 992
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 993 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1052
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1053 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1112
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1113 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1158
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1216
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1217 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1267
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1328 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1496
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1497 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1549
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1550 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1662 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1706
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1707 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1767 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 1883 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 1942 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 1994
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 1995 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2047
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2048 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2105
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2106 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2164 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2213
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2271
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2272 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1170
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1171 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1230
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1231 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1290
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1291 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1350
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1404
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1405 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1464
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1465 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1504
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1505 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1555
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1556 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1611
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1723
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1779
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1822
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1875
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 1936 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2049
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2105
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2163
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2164 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2280 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2331
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2332 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2446
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2447 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2504 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2563
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2564 LLAEENQRLREQLQLLE 2580
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1320
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1321 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1354
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1355 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1410
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1411 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1519
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1520 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1570
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1571 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1628 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1682
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1683 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1721
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1722 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1770
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1771 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1805
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1806 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1858
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 1859 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1904
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 1905 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1954
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2015 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2038
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2039 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2069
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2127
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2128 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2166
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2167 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2220
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2221 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2331
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2392 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2495
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2496 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2546 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2606 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2656 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2709
Query: 6198 KQ 6199
Q
Sbjct: 2710 AQ 2711
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1197 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1257 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1304
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1305 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1364
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1423
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1424 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1481
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1482 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1534
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1535 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1579
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1580 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1634
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1635 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1683
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1684 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1722
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1723 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1834
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1892
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 1893 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 1952 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2069
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2070 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2185 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2241
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2242 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2297
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2298 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2352
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2353 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2401
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2459
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2460 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2512
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2513 QRQQQQMEQE 2522
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1840 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1899
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 1900 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1951
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 1952 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2006
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2187 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2245
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2305
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2306 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2351
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2404
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2405 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2460
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2461 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2488
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 204 bits (520), Expect = 2e-51
Identities = 132/369 (35%), Positives = 191/369 (51%), Gaps = 44/369 (11%)
Query: 26 QAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGS 85
Q E++ QKK FT W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 37 QDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94
Query: 86 NTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLS 145
F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 95 MRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI-------- 146
Query: 146 CNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTD 205
D+ V S M+A++ LLLW+Q Y+ + +
Sbjct: 147 --------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDN 182
Query: 206 FKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVD 265
F SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PEDVD
Sbjct: 183 FTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVD 242
Query: 266 VVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTY 325
V PDEKSI+TYV+ P + + + + W ++ L L +
Sbjct: 243 VPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAA 301
Query: 326 FKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKL 384
F++ F SF E + + L K +L + D + + + L+ + A ++K
Sbjct: 302 FEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK- 356
Query: 385 NYALPPPLH 393
+PP H
Sbjct: 357 ---VPPGYH 362
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1109 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1168
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1229 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1283
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1327
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1382
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1439
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1495
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1496 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1670 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1703
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1704 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1742
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1849
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1967
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2086
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2087 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2145 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2198 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2234
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2235 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2278
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2339 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2510
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2511 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2552
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2721
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 603 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 662
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 663 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 719
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 720 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 780 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 836
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 837 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 896
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 897 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 941
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 942 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 990
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1099
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1100 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1146
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1196
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1197 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1234
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1294
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1342
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1403 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1452 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1493
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1494 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1543 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1638
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1639 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1743
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1859
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1911
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2030
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2209 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2386 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2445 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2558
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2676
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2677 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2734
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2735 ASGFLLDPVRNRRLTVNEAVK 2755
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 935 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 993
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 994 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1048
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1108
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1109 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1228 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1279
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1398
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1514
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1515 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1677
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1678 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1732
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1733 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1789
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1790 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1845 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2077 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2131
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2132 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2177
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2235 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2289
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2341
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2342 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2390
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2568 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2680
Query: 3736 EL 3737
EL
Sbjct: 2681 EL 2682
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 269 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 328
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 329 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 387
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 388 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 447
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 448 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 507
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 508 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 557
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 558 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 603
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 604 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 659
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 660 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 711
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 712 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 764
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 765 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 989
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 990 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1049
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1050 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1339 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1392 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1429
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1605
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1606 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1659
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1711
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1712 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1827
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1828 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 1991
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2046
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2225
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2284
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQ 2304
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 1015 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1074
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1180
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1238
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1239 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1350 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1518
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1519 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1571
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1572 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1684 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1789 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 1905 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 1964 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2016
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 2017 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2069
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2070 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2127
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2128 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2186 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2235
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2293
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2294 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1253 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1312
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1426
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1487 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1526
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1527 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1577
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1578 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1633
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1745
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1801
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1844
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1897
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 1958 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2071
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2127
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2185
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2186 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2302 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2353
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2354 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2469 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2586 LLAEENQRLREQLQLLE 2602
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1342
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1343 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1376
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1377 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1433 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1541
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1542 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1592
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1593 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1650 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1704
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1705 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1743
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1744 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1792
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1793 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1827
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1880
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1926
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 1927 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1976
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2037 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2060
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2061 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2091
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2149
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2150 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2188
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2189 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2242
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2243 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2353
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2414 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2517
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2518 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2628 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2731
Query: 6198 KQ 6199
Q
Sbjct: 2732 AQ 2733
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1279 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1445
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1503
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1504 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1556
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1557 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1601
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1602 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1656
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1657 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1706 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1744
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1856
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1914
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 1915 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 1974 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2091
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2092 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2207 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2264 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2319
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2320 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2374
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2375 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2423
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2481
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2482 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2535 QRQQQQMEQE 2544
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1973
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 1974 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2028
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2209 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2373
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2426
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2482
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2483 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2510
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 204 bits (520), Expect = 2e-51
Identities = 135/388 (34%), Positives = 198/388 (51%), Gaps = 45/388 (11%)
Query: 8 PTEDEQGS-WGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHV 66
P DEQ +++ + E++ QKK FT W+N L + + ISDL+ D++ GH
Sbjct: 4 PLPDEQDFIQAYEEVREKYKDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHN 61
Query: 67 LLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILG 126
L+ LLEVLSG LPR+KG F N++ AL +LR+R +KL+NI DI DGNP + LG
Sbjct: 62 LISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLG 121
Query: 127 LIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKA 186
LIWTIILHF I D+ V S M+A++
Sbjct: 122 LIWTIILHFQI----------------SDIQVSGQSE----------------DMTAKEK 149
Query: 187 LLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAF 246
LLLW+Q Y+ + +F SSWR+G F AIIH +P LIDM V ++N +NL +AF
Sbjct: 150 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 209
Query: 247 RIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWL 306
+AE++L + RLL+PEDVDV PDEKSI+TYV+ P + + + + W
Sbjct: 210 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQ 268
Query: 307 TLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQ 365
++ L L + F++ F SF E + + L K +L + D +
Sbjct: 269 EYRELVLLLLQWMRHHTAAFEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNR 324
Query: 366 LREAWDGLDHQINAWKIKLNYALPPPLH 393
+ + L+ + A ++K +PP H
Sbjct: 325 SKGIYQSLEGAVQAGQLK----VPPGYH 348
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1095 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1154
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1155 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1214
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1215 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1269
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1313
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1368
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1369 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1425
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1426 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1481
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1482 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1595
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1655
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1656 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1689
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1690 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1728
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1789 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1835
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1836 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 1896 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1953
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2013
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 2014 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2072
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2073 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2131 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2184 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2220
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2221 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2264
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2324
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2325 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2496
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2497 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2538
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2598
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2599 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2658
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2659 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2707
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 589 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 648
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 649 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 705
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 706 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 765
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 766 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 822
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 823 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 882
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 883 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 927
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 928 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 976
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 977 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1032
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1033 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1085
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1086 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1132
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1133 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1182
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1183 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1220
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1280
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1281 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1328
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1389 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1438 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1479
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1480 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1528
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1529 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1624
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1625 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1729
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1845
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1897
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 1898 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1957
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 1958 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2016
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 2017 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2195 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2372 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2431 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2544
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2604
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2605 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2662
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2663 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2720
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2721 ASGFLLDPVRNRRLTVNEAVK 2741
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 921 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 979
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 980 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1034
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1035 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1094
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1095 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1213
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1214 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1265
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1266 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1325
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1384
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1500
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1501 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1551
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1552 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1663
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1664 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1718
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1719 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1775
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1776 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1831 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1942
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2063 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2117
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2118 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2163
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2221 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2275
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2276 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2327
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2328 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2376
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2554 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2612 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2666
Query: 3736 EL 3737
EL
Sbjct: 2667 EL 2668
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 255 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 314
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 315 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 373
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 374 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 433
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 434 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 493
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 494 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 543
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 544 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 589
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 590 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 645
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 646 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 697
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 698 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 750
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 751 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 804 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 864 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 924 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 975
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 976 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1035
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1036 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1084
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1204
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1205 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1264
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1325 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1377
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1378 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1415
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1591
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1592 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1645
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1697
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1698 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1755 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1813
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1814 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1930
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 1931 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 1977
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2032
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2033 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2092
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2152
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2153 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2211
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2270
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQ 2290
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 941 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1000
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 1001 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1060
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1061 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1120
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1121 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1166
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1224
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1225 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1275
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1336 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1504
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1505 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1557
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1558 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1670 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1714
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1715 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1775 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 1891 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 1950 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2002
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 2003 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2055
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2056 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2113
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2114 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2172 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2221
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2279
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2280 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2398
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1238
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1239 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1298
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1299 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1358
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1412
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1413 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1472
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1473 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1512
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1513 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1563
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1564 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1619
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1731
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1787
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1830
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1883
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 1944 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2057
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2113
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2171
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2172 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2288 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2339
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2340 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2454
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2455 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2512 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2571
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2572 LLAEENQRLREQLQLLE 2588
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1328
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1329 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1362
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1363 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1418
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1419 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1472 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1527
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1528 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1578
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1579 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1636 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1690
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1691 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1729
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1730 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1778
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1779 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1813
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1814 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1866
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 1867 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1912
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 1913 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1962
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2023 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2046
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2047 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2077
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2135
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2136 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2174
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2175 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2228
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2229 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2283
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2339
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2400 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2503
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2504 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2554 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2613
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2614 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2664 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2717
Query: 6198 KQ 6199
Q
Sbjct: 2718 AQ 2719
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1205 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1264
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1265 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1312
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1313 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1372
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1431
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1489
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1490 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1542
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1543 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1587
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1588 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1642
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1643 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1691
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1692 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1730
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1731 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1842
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1900
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 1901 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 1960 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2077
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2078 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2193 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2249
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2250 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2305
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2306 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2360
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2361 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2409
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2467
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2468 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2520
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2521 QRQQQQMEQE 2530
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1848 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1907
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 1908 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1959
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 1960 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2014
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2195 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2313
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2314 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2359
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2412
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2413 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2468
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2469 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2496
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 204 bits (519), Expect = 2e-51
Identities = 132/372 (35%), Positives = 192/372 (51%), Gaps = 44/372 (11%)
Query: 23 ISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD 82
I + E++ QKK FT W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+
Sbjct: 61 IRIADERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE 118
Query: 83 KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
KG F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 119 KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI----- 173
Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
D+ V S M+A++ LLLW+Q Y+ +
Sbjct: 174 -----------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLR 206
Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
+F SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PE
Sbjct: 207 CDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPE 266
Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEN 322
DVDV PDEKSI+TYV+ P + + + + W ++ L L +
Sbjct: 267 DVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHH 325
Query: 323 DTYFKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWK 381
F++ F SF E + + L K +L + D + + + L+ + A +
Sbjct: 326 TAAFEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQ 381
Query: 382 IKLNYALPPPLH 393
+K +PP H
Sbjct: 382 LK----VPPGYH 389
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1136 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1195
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1196 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1255
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1256 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1310
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1311 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1354
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1409
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1410 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1466
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1522
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1523 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1697 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1730
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1731 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1769
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1829
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1830 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1876
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1877 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1994
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2054
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2113
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2114 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2172 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2225 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2261
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2262 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2305
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2365
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2366 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2537
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2538 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2579
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2639
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2640 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2699
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2700 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2748
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 630 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 689
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 690 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 746
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 747 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 806
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 807 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 863
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 864 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 923
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 924 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 968
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 969 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1017
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 1018 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1073
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1074 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1126
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1127 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1173
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1174 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1223
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1224 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1261
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1262 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1321
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1322 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1369
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1430 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1479 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1520
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1521 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1569
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1570 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1665
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1666 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1770
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1886
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1938
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 1939 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1998
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 1999 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2057
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 2058 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2236 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2413 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2472 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2585
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2645
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2646 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2703
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2704 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2761
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2762 ASGFLLDPVRNRRLTVNEAVK 2782
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 962 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1020
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 1021 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1075
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1076 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1135
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1136 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1194
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1195 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1254
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1255 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1306
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1307 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1366
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1425
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1541
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1542 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1592
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1593 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1704
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1705 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1759
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1760 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1816
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1817 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1871
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1872 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1923
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 1924 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1983
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2043
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 2044 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2104 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2158
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2159 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2204
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2262 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2316
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2317 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2368
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2369 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2417
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2595 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2653 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2707
Query: 3736 EL 3737
EL
Sbjct: 2708 EL 2709
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 296 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 355
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 356 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 414
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 415 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 474
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 475 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 534
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 535 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 584
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 585 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 630
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 631 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 686
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 687 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 738
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 739 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 791
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 792 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 1016
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 1017 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1076
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1077 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1125
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1245
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1246 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1305
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1366 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1418
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1419 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1456
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1516
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1632
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1633 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1686
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1738
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1739 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1796 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1854
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1855 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1971
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 2018
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2073
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2074 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2133
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2193
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2194 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2252
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2311
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQ 2331
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 982 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 1042 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1101
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1102 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1161
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1162 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1207
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1265
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1266 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1316
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1377 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1545
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1546 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1598
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1599 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1711 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1755
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1816 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1871
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1872 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 1932 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 1991 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2043
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 2044 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2096
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2097 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2154
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2155 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2213 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2262
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2320
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2321 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1219
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1220 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1279
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1280 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1339
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1340 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1399
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1453
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1454 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1513
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1514 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1553
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1554 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1604
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1605 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1660
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1772
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1828
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1871
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1872 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1924
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 1985 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2098
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2154
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2212
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2213 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2329 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2380
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2381 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2495
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2496 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2552
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2553 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2612
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2613 LLAEENQRLREQLQLLE 2629
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1369
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1370 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1403
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1404 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1459
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1460 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1568
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1569 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1619
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1620 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1677 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1731
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1732 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1770
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1771 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1819
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1820 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1854
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1907
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 1908 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1953
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 1954 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 2003
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 2004 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2064 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2087
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2088 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2118
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2176
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2177 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2215
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2216 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2269
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2270 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2324
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2380
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2441 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2544
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2545 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2595 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2655 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2705 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2758
Query: 6198 KQ 6199
Q
Sbjct: 2759 AQ 2760
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1246 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1305
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1306 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1353
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1354 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1413
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1472
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1473 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1530
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1531 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1583
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1584 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1628
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1629 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1683
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1684 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1732
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1733 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1771
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1772 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1883
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1941
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 1942 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 2001 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2118
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2119 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2234 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2291 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2346
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2347 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2401
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2402 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2450
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2508
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2509 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2561
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2562 QRQQQQMEQE 2571
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1948
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 1949 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 2000
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 2001 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2055
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2236 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2294
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2354
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2355 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2400
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2453
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2454 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2509
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2510 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2537
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 203 bits (517), Expect = 4e-51
Identities = 661/3648 (18%), Positives = 1425/3648 (39%), Gaps = 484/3648 (13%)
Query: 2917 LKNLKIRTNRIQRFIQNTCNEVEHKIKFC------RQFHEKTSALQEEADSIQRNELLLN 2970
L+N+++RT +IQ N E + C R+ + T+ + +E + + N+++++
Sbjct: 1817 LRNIEMRTKQIQPL---ELNLAELQDLLCQAKVLERELKDLTTLVSQELECV--NQIIIS 1871
Query: 2971 Q------EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQV 3024
Q ++ K ++++ NL+ L+++ W+ L
Sbjct: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSD-----------------TWNSRLLH------ 1908
Query: 3025 FEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNA 3084
F+ E+E K K L+ + G+ Q L + + +L +L + S+ E +
Sbjct: 1909 FQNAVEIE-KTKVLNQHTQLEGRLQDLRAWVGNKNL--------ILNSKGSNSEIDVDSL 1959
Query: 3085 QILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLEL 3144
+ Q+ E K E +L+ FD F E Q L+ ++N ++ ++L +
Sbjct: 1960 NLCLQQYEDLKQPMAERKAQLDA-LAFDIQFFISEHAQ-DLSPQQNRQMLRLLNEL---- 2013
Query: 3145 SPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQV--WAE 3202
+++ QD LE + ++ ++ LQQ L +K +Q +++ C E + W
Sbjct: 2014 ------QRSFQDILEQTAAQVDALQGHLQQMEQEAL-VKTLQKQQNTCHQQLEDLCSWVG 2066
Query: 3203 MC-----------SIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
+ + ++A++K + + D++ + F + + ++ L
Sbjct: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126
Query: 3252 NDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQ 3311
+ LT +E + +A E +L+ RV EE++ L+++ E +
Sbjct: 2127 SP--RELTALREKLHQAKEQYEALQE---ETRVAQKELEEAVTSALQQETEKSKAAKELA 2181
Query: 3312 DLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRK 3366
+ +K+ + S + QL L + + A E T+ Y+ + K
Sbjct: 2182 ENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG--YMGVNQAPEK 2239
Query: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
+++ ++ + +L Q + + L+ + A L+Q NL T EE L+Q L
Sbjct: 2240 LDKQCEMMKARHQELLSQQQNFI-LATQSAQAFLDQHG---HNL--TPEEQQMLQQKLGE 2293
Query: 3427 LRLRCTEN--DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAII 3484
L+ + + + LK V L ++ L+ KE+E W E ++E
Sbjct: 2294 LKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE-------------- 2339
Query: 3485 LDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ---LLLTLLLQRIRSIQNV 3541
L+N+ K ++ E L LL + E+V + +T+ Q++ ++N
Sbjct: 2340 LENMH---------KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 2390
Query: 3542 PESSGAVETVPAF--QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFF 3599
+ + ++ ER L K + + + + H F +L+ +
Sbjct: 2391 FKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 2450
Query: 3600 QQTTTSFQNM----AFQDHPEKSEQF---EELQSILKKGKLTFENIMEKLRIKYSEMYTI 3652
Q + + + D EQ ++LQ L + ++ E + + R ++ I
Sbjct: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR----DIMEI 2506
Query: 3653 V--PAEIESQVEECRKALEDIDEKISNEVLKSSP--------SYAMRRKIEEINNGLHNV 3702
PA V+E ++ + +S + + S S +++ +E + + V
Sbjct: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEV 2566
Query: 3703 EKMLQQKSKN------IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQ-DPGQAQEW 3755
E+ L+ K + I++A K+ ++ S L V +E D A
Sbjct: 2567 EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2626
Query: 3756 MDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYD 3815
L Q+++Q+ + + + S L K + E + L + ++EN S +LA+ D
Sbjct: 2627 QGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD 2686
Query: 3816 SLRTLSHHASTVQ---MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVT 3872
+ ++H +Q + +ED ++ + L + +L + + +Q L T
Sbjct: 2687 --QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFT 2744
Query: 3873 ALQQKIME---SLPQIQRMADD----VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE 3925
LQ+ + E Q D+ V + +K E + +T + +KE+ E+
Sbjct: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL-----EK 2799
Query: 3926 HLKHGEVILENIRPMKKTIAEIVSYQVELR------------------LPQTGMKPLPV- 3966
++H + +L++ + EI L LP G V
Sbjct: 2800 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2859
Query: 3967 -FQRTNQL------LQDIKL----LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNY 4015
+ L + D+ L L V E+ E L+ ++ + E +E ++ Q L +
Sbjct: 2860 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
Query: 4016 SAQF-SLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQE 4074
S++ MS + + Q E + L N K + + A +L + + QE
Sbjct: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN-SQE 2978
Query: 4075 QEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
E ++ + + E A +R+L S S+LA + AE
Sbjct: 2979 AENWKKIQEELNSRWERATEVTVARQRQLEE--SASHLACFQA---------------AE 3021
Query: 4135 PSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC 4194
+ W ME++ G + + + + Q + + Q E
Sbjct: 3022 SQLRPWL--------MEKELMMGVLGPLSIDP--NMLNAQKQQVQFMLKEFEARRQQHE- 3070
Query: 4195 SLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ N+ +G +L +S Q L+ + + E T+ L++ +Q+ +
Sbjct: 3071 --QLNEAAQGILTGPGDVSLSTSQVQKELQS-INQKWVELTDKLNSRSSQIDQ------- 3120
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
A+ T ++ Q L +++ L+ ++ ++ E K Q L + + + E
Sbjct: 3121 ---AIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPEAVKQQ-LEETSEIRSDLEQ 3175
Query: 4315 LSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEP-EHQEALQPVNLSELESIVTER 4373
L ++K + +++ +++ E++ +D+ L+ + P + E L ++ L++ +
Sbjct: 3176 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 3235
Query: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSP 4433
QF + D + + L+ K +Q K +AK Q +N+ Q+S + + S
Sbjct: 3236 QQFQQMFD-ELRTWLDDKQSQQA---KNCPISAKLERLQSQLQENEEFQKS-LNQHSGSY 3290
Query: 4434 ENDVPDS---ILS-PQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
E V + +LS P G+ Q EL + + L + + S + Y
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWE-ELSKKTADRQSRLKDCMQKAQKYQ 3349
Query: 4490 FRY----PTTEELKTYTTQL----EDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS 4541
+ P E+ K ++L + ++ E+S L+++ + E + + L E+ + +
Sbjct: 3350 WHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE---VEKRRSLLEILNSAA 3406
Query: 4542 QCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK----GDLLKAMTWPG 4597
L + E E + G Q + T L+ K L ++ + K +
Sbjct: 3407 DILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV 3466
Query: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQ 4657
E LE FD L + C +K+L+ R+ Q ++ L Q+ + Q
Sbjct: 3467 EGAKHQLEIFDAL--------GSQACSNKNLEK----LRAQQEVLQALEPQVDYLRNFTQ 3514
Query: 4658 QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLD 4717
+ + S A QL L AE + + +R++ +++ KLE +
Sbjct: 3515 GLVEDAPDGSDASQL---------LHQAEVAQQEFLEVKQRVNSGCVMMEN--KLEGI-- 3561
Query: 4718 SMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIE 4777
G R E+ S + D L GM IG++ +LQ+QIE
Sbjct: 3562 ---GQFHCRVREMFSQL---ADLDDELDGMGA---IGRDT------------DSLQSQIE 3600
Query: 4778 NHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
+ ++F K+ L I+A A+ L E + + + LE ++QCG +
Sbjct: 3601 DVRLFLNKIHVLKLDIEASEAECRHML---EEEGTLDLLGLKRELEALNKQCGKLTERGK 3657
Query: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETE----------ERLVERISFYQQI-KR 4886
+ E+ + +E L + + EE E E + ++++ ++ K
Sbjct: 3658 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKE 3717
Query: 4887 NIGGKHARLYQTLNEGKQLVASVS----CPELEGQIAKLEEQWLSLNKKIDHELHRLQAL 4942
+ +L Q G+ L+ S LE + ++ +W +LNKK+ + +LQ
Sbjct: 3718 QVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777
Query: 4943 LKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKS 5002
L H + + L WL ++ + K S + +++ I + +D++
Sbjct: 3778 LLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQRLLDDRK 3833
Query: 5003 SLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPS 5061
+ + + G ++ E D + L E +WT L+++ Q++L + +
Sbjct: 3834 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893
Query: 5062 RKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQS 5121
+ + +++ E + ++ + V + ++ +++ + +HK +E D + D V+Q+
Sbjct: 3894 HETAEPISDFLSVTEKKLANSEPVGTQTA--KIQQQIIRHKA--LEEDIENHATD-VHQA 3948
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE-SENKIQ 5180
+ + + E+ +E + + ++ + RK L+Q L + E++++
Sbjct: 3949 VKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008
Query: 5181 ILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA 5240
+LN WL E++L ++ V ++ +L Q ++ LA+ + ++ K +++G
Sbjct: 4009 VLN-WLAEVEDKLSSV----FVKDFKQDVLHRQHADH-LALNEEIVNRKKNVDQAIKNGQ 4062
Query: 5241 VPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQL-------YDEVNMMT 5293
L + T + + +K + T+ + + L+ + QL Y+E+
Sbjct: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 4122
Query: 5294 IRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVA- 5352
+ S + E + + + L+ E + + EV L L P A
Sbjct: 4123 REVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAR 4182
Query: 5353 EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLA 5412
E +++ + ++++ V+ I ++ + + +Q + Y A A + + + K L
Sbjct: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 4242
Query: 5413 NISMSGNNLAEILPPALQDIKELQHDVQKTK----EAFLQNSSVLDRLPQPAESSTHMLL 5468
I + + LQ K D+ + K E F S + + ++
Sbjct: 4243 PIRLEQDQTTA----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 4298
Query: 5469 PGPLHSLQRAAYLEKMLLVKANEFEFVLSQF----KDFGVRLESLKGLIMH------EEE 5518
+ + + L + + +++QF ++ +E + LI + E
Sbjct: 4299 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358
Query: 5519 NLDRLHQQEKENPDSFLNH---VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQW 5575
L + ++ ++ +S H + L P ++ LN ++ + + +NM Q
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV--EEKYQKAENMYAQI 4416
Query: 5576 ---IRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK 5632
+R A AL+ Q + E +KIE L+ +L L + +
Sbjct: 4417 KEEVRQRALALDEAVS-QSTQITE-----------FHDKIEPMLE-----TLENLSSRLR 4459
Query: 5633 TYKMLEAEVS-INQTIADSY-VTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQGV 5688
++ AEV I + I+D+ T L+ L + ++ R E + S+ D+ A
Sbjct: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA---- 4515
Query: 5689 RQRKGDVDGLVRQWQD-----------FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQT 5737
++ + +D +V W+D F +E +F D + LL+ +K T
Sbjct: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK--------DT 4567
Query: 5738 RSLIHELKNKEIH--FQRRRTTCALTLEA---------------GEKLLLTTDLKTKESV 5780
+ ++H+L++ I +++ A T++ G L+ K V
Sbjct: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEV 4627
Query: 5781 GRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQ--VLKAQSEDPLP 5838
+ I ++ ++W+++ E +++ + ++ Q + ++ + L V+K + +P
Sbjct: 4628 RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MP 4684
Query: 5839 ELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD----LTRHVLVEDVMVLKEQIEHL 5894
+ DL+ K+ + E+++ Q E++ + L + D +++E + L
Sbjct: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4744
Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMI-- 5952
WE+L ++A R+ ++E L F +EL +WL E + IS + +
Sbjct: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4804
Query: 5953 -EKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVI 6010
E + ++ L + ++ + + G++L+++S A+ + +L +N W+ +
Sbjct: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
Query: 6011 GSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQQD 6068
R ++L+ T Q + + L R+ES+LS KP + + EQ D
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT-------GGLPETAREQLD 4917
Query: 6069 LQRDIEQHSAGVESVFN-ICD-----VLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
++ E +N + D +L D ++TE Q+ L+++W + +
Sbjct: 4918 THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE-----QSVALLEQKWHVVSS 4972
Query: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
ER+ K+EE L +F + F +WL AE++ + ++ + +++ + F
Sbjct: 4973 KMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVF 5032
Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+++ Q+ +++ +L ++ +K ++ RW+ + +R R L
Sbjct: 5033 ANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDD 5092
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNK 6299
+ ++F + ++ WL + + L + S +D D QL+ FQ+ +
Sbjct: 5093 ARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPV 5151
Query: 6300 IDQLIVFGEQLIQKS-EPLDAVLIEDELEELHRYCQEVFGR-VSRFHR 6345
D I G L +K+ P D+ +++ L E+ V G+ V R H+
Sbjct: 5152 YDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
Score = 194 bits (493), Expect = 3e-48
Identities = 338/1738 (19%), Positives = 664/1738 (38%), Gaps = 205/1738 (11%)
Query: 4740 QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ-----KLVADMLLIQ 4794
QDAL + ++ + +E +A+ + KV ++AQI+ K+ + K DML +
Sbjct: 3785 QDAL-EPLLSWLADTEELIANQKPPSAEYKV-VKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
Query: 4795 ----AYSAKI-----LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDE 4845
A SA++ + L++ E+ W E +++ +++ L+ +L ++F E
Sbjct: 3843 GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ-------LEDILVLAKQFHE 3895
Query: 4846 NYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQL 4905
+ L + L + V ++ ++I ++ ++ +I ++Q + G+ L
Sbjct: 3896 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
Query: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS----YNRDSDQLTKWLE 4961
+S++ P +G +++ + + +I R ALL LS + D ++ WL
Sbjct: 3956 -SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLA 4014
Query: 4962 SSQHTLNYWKEQSLNVSQ-DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
+ L+ S+ V D + + ++E+ + I G LL K+
Sbjct: 4015 EVEDKLS-----SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL--KQ 4067
Query: 5021 T---DTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEH 5077
T + ++ L + ++ + L Q + + E+ W+ VE
Sbjct: 4068 TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE 4127
Query: 5078 QTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYER 5137
+ + SP+ Q+ Q+ KE + E+ + ++D VN+ +S +E +
Sbjct: 4128 ELATSGG-QSPTG-EQIPQFQQRQKELKKEVMEHRLVLDTVNE----VSRALLELVPWRA 4181
Query: 5138 TEFAEHL-GEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL 5196
E + L + N Q+ V + +++ ++ ++ + E W+ + +L L
Sbjct: 4182 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
Query: 5197 QKPESVISVQKLLLDCQDIENQLAI-KSKALDELKQSYLTLESGAVPLLEDTASRIDELF 5255
+ L+ QL + K+ ++D ++ +DELF
Sbjct: 4242 GP---------IRLEQDQTTAQLQVQKAFSIDIIRHK----------------DSMDELF 4276
Query: 5256 QKRSSVL-----TQVNQLKTSMQSVLQEWKIYDQLYDE-------VNMMTIRFWYCMEHS 5303
RS + Q L+ +S++Q+++ L E ++ +FW E
Sbjct: 4277 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336
Query: 5304 KPVV--------------LSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCP 5349
P + + E LR Q E ++ L++ + +KL ++ +LK L P
Sbjct: 4337 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP 4396
Query: 5350 SVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQ 5409
E++EEK Q + Q+ + + + + + H + E +
Sbjct: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKI-------EPMLE 4449
Query: 5410 QLANISMSGNNLAEILPPALQDIKELQHD----------VQKTKEAFLQNSSVLDRLPQP 5459
L N+S S + ++P + I+E D +Q + EA + L Q
Sbjct: 4450 TLENLS-SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
Query: 5460 AESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL-ESLKGLIMHEEE 5518
A+ + L + + + + +A E E + + + L+ ++
Sbjct: 4509 ADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
Query: 5519 NLDRLHQQEKE--NPDSFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAV--------- 5565
D +H E +P V A + + L+E +++ +D+
Sbjct: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
Query: 5566 --KTLQNMNRQWIRATATALERCSEL----QGIGLNEKFLYCCEKWIQLLEKIEEALKVD 5619
K++ MN W T ER +L Q + L W+ I+
Sbjct: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPP 4685
Query: 5620 VANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE-FSKLT 5678
V L + +Q K + EV Q + Q +L E + I E ++L
Sbjct: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELK 4745
Query: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSA---VKGQERFSLY 5735
W+N + + R+ ++G + F ++E L +LT T LL A + G +
Sbjct: 4746 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEV 4805
Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
+ H LKN + Q T +AG +LL ++ S+ R+ + W+ +
Sbjct: 4806 ELAKH-HVLKNDVLAHQ---ATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
Query: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ--SEDP---LPEL-HEDLHNEKE 5849
+ E +Q QST++ +I++ L +++Q + P LPE E L E
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921
Query: 5850 LIKELEQSLASWTQNLKELQTM---KADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
L +L+ ++ Q L + + M + D E + L EQ +W + ++
Sbjct: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKME 4975
Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK---------VLQTADISIEEMIEKLQK 5957
RK ++E+ LN F +E WL E +L T IEE K
Sbjct: 4976 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE-----HK 5030
Query: 5958 DCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
E+N + ++L Q G+QL S K I + L + RW+ + R + L
Sbjct: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
Query: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
+ +Q + L WL ES L + D +I+ +L++ ++ Q+ +
Sbjct: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN-DPDKIKLQLSKHKEFQKTL---- 5145
Query: 6078 AGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR-------RWRNICAMSMERRMK 6130
G + V+ D + A +T + + ++ LD +W +C S+ER+ K
Sbjct: 5146 GGKQPVY---DTTIRTGRALKEKT---LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
Query: 6131 IEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERL 6190
+EE +F+D DWL E A + + FQ+++ +R
Sbjct: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 5259
Query: 6191 TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEF 6250
++++ + R L +R DT + +K + E + RWD + + + RL Q E F
Sbjct: 5260 GTVQVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF 5318
Query: 6251 EGTRESILVWLTEMDLQLTNVEHFSESDADD--KMRQL----NGFQQEITLNTNKIDQLI 6304
T +L WL+E + L F + DD ++ L F +++ ++ +
Sbjct: 5319 RDTVHMLLEWLSEAEQTL----RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAV 5374
Query: 6305 VFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASE 6362
GE ++ P I+ + + +EV + +RL + L E E
Sbjct: 5375 AMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE 5432
Score = 188 bits (478), Expect = 1e-46
Identities = 631/3394 (18%), Positives = 1314/3394 (38%), Gaps = 522/3394 (15%)
Query: 3124 KLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIK 3183
K N N + ++ QN+ E DEK L + L +L I+ + +Q + L +
Sbjct: 1781 KGNGGVNPEPFRATQNVFTRQLCLEHDEK-----LVSYLSLLRNIEMRTKQIQPLELNLA 1835
Query: 3184 HIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENS-----SEASDVETKL-----REF 3233
+Q+ + + + +K +T + Q E S+ +V +L ++
Sbjct: 1836 ELQDLLCQAKVLERE-------LKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA 1888
Query: 3234 EDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPE--- 3290
++LQ L++ D + L ++N ++ T+ + T LE + R VGN
Sbjct: 1889 KNLQKSLSSVSDTWNSRLLH-FQNAVEIEK--TKVLNQHTQLEGRLQDLRAWVGNKNLIL 1945
Query: 3291 -----------ESLEMPLRKQEELESTVAH-----------IQDLTEKLGMISSPEAKLQ 3328
+SL + L++ E+L+ +A IQ + SP+ Q
Sbjct: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQ 2005
Query: 3329 -------LQYTLQELVSKNSAMKEAFKA--QETEAERYLENYKCYRKMEEDIYTNLSKME 3379
LQ + Q+++ + +A +A + Q+ E E + K +K + + L +
Sbjct: 2006 MLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV---KTLQKQQNTCHQQLEDLC 2062
Query: 3380 TVLGQSMSSLP----LSYREALERLEQSKALVSNLIST-KEELMKLRQILRLLRLRCTEN 3434
+ +GQ+ +L + ++ L L+++++ + +L + +++ + EN
Sbjct: 2063 SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 2122
Query: 3435 DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPE 3494
+ ++AL EK L AKE E L++E + +E+E + LQ+E +
Sbjct: 2123 QTKLSPRELTALREK----LHQAKEQY---EALQEETRVAQKELEEA--VTSALQQETEK 2173
Query: 3495 ISKTKEAATTEE-LSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPA 3553
KE A ++ + LLD + G + QLL L + + GA++T
Sbjct: 2174 SKAAKELAENKKKIDALLDWVTSVGSS--GGQLLTNL--PGMEQLSGASLEKGALDTTDG 2229
Query: 3554 FQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQD 3613
+ + N+ +K+ K E+++ RH +E+++ + F T S Q AF D
Sbjct: 2230 YMGV-------NQAPEKLDKQCEMMKA----RH---QELLSQQQNFILATQSAQ--AFLD 2273
Query: 3614 HPEKSEQFEELQSILKK-GKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
+ EE Q + +K G+L E Y+ A+ E+++++ + +++
Sbjct: 2274 QHGHNLTPEEQQMLQQKLGEL-------------KEQYSTSLAQSEAELKQVQTLQDELQ 2320
Query: 3673 EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHS 3732
+ + + S +++E ++ G + E + + ++++ D + S
Sbjct: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTIS 2380
Query: 3733 KLNELDSEVQDIVEQDPGQAQEWM-DNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYS 3791
LD E ++P + + D L ++Y + + S LN + ++
Sbjct: 2381 GQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQ 2440
Query: 3792 DLLKSTEAWIE----NTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL--LHSIF 3845
+ S +AW++ N LL++ D A+T Q+ E +E + + L +
Sbjct: 2441 NSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVA 2500
Query: 3846 MDLEDLS---------IIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIE 3896
D+ ++ + TD + Q LS + + +++ Q Q + + + ++
Sbjct: 2501 RDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
Query: 3897 SEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRL 3956
+ +E+ + + LS + + ++K + I ++ T E+V+ +E
Sbjct: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEAT-REMVTRFMETAD 2619
Query: 3957 PQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
T +Q + + L + QE+ LK ++ Q ++ L+Q + N S
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQ---QEKESSLKKLLPQAEMFEHLSGKLQQFMENKS 2676
Query: 4017 AQFSLEHMSPDQA-----DKLPQLQGEIERMEKQILSLNQRKEDLLVDLKAT--VLNLHQ 4069
+ + PDQ ++ +L E+E ++ + +L E L+ +L + L+L Q
Sbjct: 2677 RMLASGNQ-PDQDITHFFQQIQELNLEMEDQQENLDTL----EHLVTELSSCGFALDLCQ 2731
Query: 4070 HLKQEQ----EGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVE--ESS 4123
H + Q + E + ++ + E + R +L E + E+S
Sbjct: 2732 HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS 2791
Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
+ + +++ E H K + +D AS GT+V+E K ++ +N + +I P
Sbjct: 2792 MSAKELEKQIE-----------HLKSLLDDWASK--GTLVEEINCKGTSLENLIMEITAP 2838
Query: 4184 DSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKT 4243
DS Q + G+ P ++ S + H CK
Sbjct: 2839 DS--------------QGKTGSILPSVGSSVGSVNG------------------YHTCK- 2865
Query: 4244 QVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIE--HKVA-FLLETCKDQ 4300
+ E++ + N+ E + VL ++ QA+L +E HK A +L+ + +
Sbjct: 2866 DLTEIQCDMSDVNLKYE------KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
Query: 4301 GLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKS--------SEP 4352
+ +A + K +TVK E + L E E P I K + P
Sbjct: 2920 ---EEVLKSMDAMSSPTKTETVKAQAESNKAFLAE--LEQNSPKIQKVKEALAGLLVTYP 2974
Query: 4353 EHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLE---------------LKP-MEQK 4396
QEA N +++ + R + + + +Q+ LE L+P + +K
Sbjct: 2975 NSQEA---ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEK 3031
Query: 4397 DFIKFI---------EFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQ 4447
+ + + NA+K Q+ +E A Q N+ IL+ G
Sbjct: 3032 ELMMGVLGPLSIDPNMLNAQKQQVQF------MLKEFEARRQQHEQLNEAAQGILTGPGD 3085
Query: 4448 NGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLED 4507
+ L Q+ + S N + N R ++ +TQ ++
Sbjct: 3086 ---------------VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 3130
Query: 4508 LRQEAS----------NLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEML----EM 4553
L Q+ S ++Q+ + EA ++ E+ L Q V+E E+
Sbjct: 3131 LLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL 3190
Query: 4554 PRLYREDGSGQQV--HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ 4611
L E ++ ET+AL L+ L +D+ L A+ +T + FD L+
Sbjct: 3191 SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA----STQQFQQMFDELR 3246
Query: 4612 VCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQ 4671
L+ Q S+ K N +++RL QL + Q+SLN+ SG
Sbjct: 3247 TWLDDKQ------SQQAK-----NCPISAKLERLQSQL-QENEEFQKSLNQHSG------ 3288
Query: 4672 LQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS 4731
+Y V + ES + + E+ L ++ +L++ + + R + L
Sbjct: 3289 -----SYEVIVAEGESLLLSVPPGEEK----RTLQNQLVELKNHWEELSKKTADRQSRLK 3339
Query: 4732 SPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV--AD 4789
+ ++ +V ++ K K++ L+ T V L++ + K ++
Sbjct: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRS 3397
Query: 4790 MLLIQAYSAKILPSLLQNRETFWAEQVTEVK-----ILEEKSRQCGMKLQSLLQKWEEFD 4844
+L I +A IL + + E ++ + + EE + G L+ + Q+ EF
Sbjct: 3398 LLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG-SLEEMTQRLREFQ 3456
Query: 4845 ENYASLEKDLE------ILISTLPSVSLVEETEERLVERISFYQQIKRNI---------- 4888
E++ ++EK +E + L S + + E+L + Q ++ +
Sbjct: 3457 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3516
Query: 4889 ------GGKHARL-------YQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE 4935
G ++L Q E KQ V S C +E ++ + Q+ +++ +
Sbjct: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNS-GCVMMENKLEGI-GQFHCRVREMFSQ 3574
Query: 4936 LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFS 4995
L L L + + RD+D L +E + LN L D++ + + E
Sbjct: 3575 LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKL----DIEASEAECRHMLEEE 3630
Query: 4996 KEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
+D LK + ++ Q L E A +++ + + ++ D KL L
Sbjct: 3631 GTLD-LLGLKRELEALNKQCGKLTERGKAR--------QEQLELTLGRVEDFYRKLKGLN 3681
Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
+ +A E + W+ E + ++ + QK + ++M +Q V
Sbjct: 3682 DATTAAEEA--EALQWVVGTEVEIINQQLADF--------KMFQKEQVDPLQMKLQQ--V 3729
Query: 5116 DFVNQSLLQLS--TCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESIT 5173
+ + Q L+Q + CDV+ ++ + E+N +W+ ++ + ++I L++ L
Sbjct: 3730 NGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
Query: 5174 ESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSY 5233
+ ++ ++ L +WL EE + + P + V K + Q + +L KA ++ Q+
Sbjct: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQA- 3841
Query: 5234 LTLESGAVPLLEDTASR------IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYD 5287
E G + + A R ++ L + + +L++ + ++ +L K + + +
Sbjct: 3842 ---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3898
Query: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
++ + +S+PV ++ Q+ ++L+++ E+ + ++ L L
Sbjct: 3899 PISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL 3958
Query: 5348 -CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH--GEAAARLKQQ 5404
P+ ++ EK + R+++ I D+ + +LL +A SNA GE +
Sbjct: 3959 TSPAEQGVLSEKIDSLQARYSE----IQDRCCRKAALLD--QALSNARLFGEDEVEVLNW 4012
Query: 5405 EAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESST 5464
A+ + + + ++L D L ++ K+ Q L +
Sbjct: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
Query: 5465 HMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLES----LKGLIMHEEENL 5520
+L+ L + + Y + + V +++ L Q + + +S L G + EE L
Sbjct: 4073 VLLIQEKLDGI-KTRYAD--ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL 4129
Query: 5521 -------------DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKL------PLS 5561
+ Q++KE + H L L + +NEVS L
Sbjct: 4130 ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL-------DTVNEVSRALLELVPWRAR 4182
Query: 5562 DVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVA 5621
+ K + + N Q+ + T +R E+ IQ ++ E+A ++A
Sbjct: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAA-------------IQRSQQYEQAADAELA 4229
Query: 5622 NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRW 5681
++K + + +QT A V ++ + ++ E + S++
Sbjct: 4230 WVAE---TKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTC 4286
Query: 5682 QNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAV-KGQERFS--LYQTR 5738
+ V Q K + L++Q++ + + L L++ + E S + +TR
Sbjct: 4287 GEEQKTVLQEK--TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETR 4344
Query: 5739 SLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQL 5798
+LI +L + I ++ R + E L + + ++ ++ K++ P+
Sbjct: 4345 ALIAQLPSPAIDHEQLRQ------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
Query: 5799 AEMIKQ-FQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQS 5857
EM+++ +Q + Q ++++++ L +QS + E H+ + E ++ L
Sbjct: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ-ITEFHDKIEPMLETLENLSSR 4457
Query: 5858 LASWTQNLKELQTMKADLTRHVLVE------DVMVLKEQIEHLHRQWEDLCLRVA----- 5906
L + L + D R + + ++ L+ E L R+ E+L R
Sbjct: 4458 L-----RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
Query: 5907 IRKQEIEDRLNTWVVFNEKNK--------------ELCA--W--LVQMENKVLQTADI-- 5946
+ +EI+D+L+ V F E K EL W + + + T DI
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
Query: 5947 -----SIEEMIEKLQKDC----MEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLN 5997
I+ I K Q + EE + E ++ +G LI A ++ E+ ++
Sbjct: 4573 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSID 4632
Query: 5998 KINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCD 6055
++N+ W++L R++KL++ Q + + WL +L PV D+
Sbjct: 4633 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL-- 4690
Query: 6056 DQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR 6115
++ +L E ++ + ++ Q +E + + +++L + +ET+ D I++ L
Sbjct: 4691 -NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA---TDETDRDIIREPLTELKH 4746
Query: 6116 RWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
W N+ R+ K+E +F WL E + E
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
Query: 6176 LKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTA 6235
L + + + +E +NK L + D AS L+ + NQ W+++ ++
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
Query: 6236 VLRRLRHFTNQREEFEGTRESILVWLTEMDLQLT 6269
++L+ Q + F E L+ LT M+ QL+
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS 4900
Score = 172 bits (435), Expect = 1e-41
Identities = 667/3536 (18%), Positives = 1349/3536 (38%), Gaps = 517/3536 (14%)
Query: 2139 KLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-LQEKKAQLKIYKKFLKKAQDLTS 2197
+L LE ++ L S L L IE++ KQ L LQ+ Q K+ ++ LK DLT+
Sbjct: 1801 QLCLEHDEKLVSYLSL-LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELK---DLTT 1856
Query: 2198 LLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVC 2257
L+ + LEC S+ + + LL+ L+ +NL
Sbjct: 1857 LVSQE-------LECVNQIIISQP-----QEVPAQLLKALEKDAKNLQ------------ 1892
Query: 2258 VTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALA--KS 2315
L++ D ++ + F Q AVE ++K + L L+ G L+ + A K+
Sbjct: 1893 -KSLSSVSDTWNSRLLHF------QNAVE--IEKTKVLNQHTQLE-GRLQDLRAWVGNKN 1942
Query: 2316 VKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI-------LKSKRSTE 2368
+ N+ +I D + + +DL+ +A K +++ I + +
Sbjct: 1943 LILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQ 2002
Query: 2369 KKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMK 2428
+ L +++ D+ E T +A V+ L+ + + A+ + KQ + Q+
Sbjct: 2003 NRQMLRLLNELQRSFQDILEQT--AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ--- 2057
Query: 2429 NTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
+ +L + + + L Q ++ + L+ ++ +K L Q + N+ + A
Sbjct: 2058 -------LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDL-QDDIQNRATSFA 2109
Query: 2489 LVLHNI-GYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLK 2547
V+ +I G+ ++ L +T + K L +E A++ + + E
Sbjct: 2110 TVVKDIEGFMEENQTKLSPRELTALREK------LHQAKEQYEALQEETRVAQKELEEAV 2163
Query: 2548 VGPLDSVTYLDKIKKFIASIEKEKDSL----GNLKIKWENLSNHVTDMDK---KLLESQI 2600
L T K K +A +K+ D+L ++ L ++ M++ LE
Sbjct: 2164 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 2223
Query: 2601 KQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS--PEE 2658
G+ V Q +K Q + L+++ Q+ ++ Q Q L + PEE
Sbjct: 2224 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 2283
Query: 2659 RAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEP 2718
+ L L K +S Q+E ++K++ + L+D + + + E
Sbjct: 2284 QQ------MLQQKLGELKEQYSTSLAQSEAELKQV------QTLQDELQKFLQDHKEFES 2331
Query: 2719 LHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQ---IRKCKVTHDGI 2775
+E +++ ET+ G + +D++S +R ++ +
Sbjct: 2332 WLERSEKELENMHKGGSSPETLPSLLKRQGSFS-------EDVISHKGDLRFVTISGQKV 2384
Query: 2776 LARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEE 2835
L + S + + K PS G+ + + L+D +Y L K T+ L L +
Sbjct: 2385 LDMENSFK------EGKEPSEI---GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQ 2435
Query: 2836 RSNFFAIIRKFQLMVQESETLI-------------IPRVETAAT---EAELKHHHVTLEA 2879
F Q +Q E + + + + A T + EL H V +E
Sbjct: 2436 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 2495
Query: 2880 SQK---ELQEIDSGIST---HLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQN 2933
QK ++ EI+ + H+QE T+ L+ F+ L +L R++ +Q+ I
Sbjct: 2496 LQKVARDIMEIEGEPAPDHRHVQETTDSI--LSHFQSLSY-----SLAERSSLLQKAIAQ 2548
Query: 2934 TCNEVEHKIKFCRQFHEKTSALQ-EEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIK 2992
+ + E + E L+ ++ S+ + N +K++I K L A +
Sbjct: 2549 SQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATR 2608
Query: 2993 CCILQVLKLKKVFDYIGLNWDFSQL----DQLQTQVFEKEKELEEKIKQLDTFEEEHGKY 3048
+ + ++ L +++ +QL Q EKE L++ + Q + FE GK
Sbjct: 2609 EMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKL 2668
Query: 3049 QALL---SKMRAIDLQ--------IKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKC- 3096
Q + S+M A Q +++ E+ L+ D L + E + C
Sbjct: 2669 QQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV----TELSSCG 2724
Query: 3097 ----LCDEIIKKLNENKTFDDSFK-----EKEILQIKLNAEENDKLYKVLQNMVLE---- 3143
LC + N K F + K EK+ + +E KL + Q + E
Sbjct: 2725 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2784
Query: 3144 LSPKE--LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQN---------EKDNC 3192
+ P E + K + ++E +L+ S+ IN + ++N +
Sbjct: 2785 IPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKT 2844
Query: 3193 EAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLN 3252
+ V + + S+ K E + SDV K + + + S+ N +
Sbjct: 2845 GSILPSVGSSVGSVNGYHTC-KDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRME 2903
Query: 3253 DAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQD 3312
+ ++ + + E + S++A+ P + + + E ELE IQ
Sbjct: 2904 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE--TVKAQAESNKAFLAELEQNSPKIQK 2961
Query: 3313 LTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKM 3367
+ E L + +S EA+ + +EL S+ E A++ + E + C++
Sbjct: 2962 VKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020
Query: 3368 EEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLL 3427
E + L + E ++G + L + + +Q + ++ + +++ +L + + +
Sbjct: 3021 ESQLRPWLMEKELMMG-VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGI 3079
Query: 3428 RLRCTENDGICL-----LKIVSALWEKWLSLLE--------------AAKEWEMWCEELK 3468
T + L K + ++ +KW+ L + + +++ ++L
Sbjct: 3080 ---LTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLS 3136
Query: 3469 QEWKFVSEEIEREAIIL---DNLQEELPEIS-----------KTKEAAT-TEELSELLDC 3513
++ + V + + ++ I + ++++L E S + KEA T +ELS L+
Sbjct: 3137 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG- 3195
Query: 3514 LCQYGENVEKQQL-LLTLLLQRIRSI--QNVPESSGAVETVPAFQEI-----TSMKERCN 3565
QY ++ K++L + L LQ + + + A+ + FQ++ T + ++ +
Sbjct: 3196 -EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQS 3254
Query: 3566 KLLQK--VQKNKELVQTEIQERHSFTKE------------------IIALKNFFQQTTTS 3605
+ + + E +Q+++QE F K ++++ ++ T
Sbjct: 3255 QQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQ 3314
Query: 3606 FQNMAFQDH-PEKSEQFEELQSILK-------KGKLTFENI---MEKLRIKYSEM-YTIV 3653
Q + ++H E S++ + QS LK K + E++ +E + K SE+ T+
Sbjct: 3315 NQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLD 3374
Query: 3654 PAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNI 3713
P ++ES + + L +++++ S + +S + + E +G+ + + + Q +
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434
Query: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRA 3773
+E+Q K L+ +L E ++I ++ G + + + + +A
Sbjct: 3435 --TEELQAKT-GSLEEMTQRLREFQESFKNIEKKVEGAKHQ--------LEIFDALGSQA 3483
Query: 3774 ECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQM---- 3829
C L K + E L + T L+ + D L H A Q
Sbjct: 3484 -CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3542
Query: 3830 --------------ALEDSEQKHNLLHSIFMDLEDL--------SIIFETDELTQSIQEL 3867
LE Q H + +F L DL +I +TD L I+++
Sbjct: 3543 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3602
Query: 3868 S---NQVTALQQKIMESLPQIQRMAD-----DVVAIESEVKSMEKRVSKIKTILLSKEIF 3919
N++ L+ I S + + M + D++ ++ E++++ K+ K+ ++
Sbjct: 3603 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKAR--- 3659
Query: 3920 DFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKL 3979
+E L+ +E+ K + + + E Q + + NQ L D K+
Sbjct: 3660 ----QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG--TEVEIINQQLADFKM 3713
Query: 3980 LENVTQEQNELLKVVIKQTNEW----------DEEIENLKQILNNYSAQFSLEHMSPDQA 4029
+ +EQ + L++ ++Q N D +++ L+ + +A+++ ++ A
Sbjct: 3714 FQ---KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNT--LNKKVA 3768
Query: 4030 DKLPQLQ------GEIERMEKQILSLNQRKEDLLVDLK--ATVLNLHQHLKQEQEGVER- 4080
++ QLQ G+ + + +LS E+L+ + K + + + QEQ+ ++R
Sbjct: 3769 QRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL 3828
Query: 4081 --DRLPAV--TSEEGG-------VAERDASERKLNRRGS-----MSYLAAVEEEVEESSV 4124
DR V EGG +A+R+ +L S +S AA ++++E+ V
Sbjct: 3829 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILV 3888
Query: 4125 KSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPD 4184
+ E AEP S K K + + + I Q+ + L D
Sbjct: 3889 LAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQII---------RHKALEED 3937
Query: 4185 SLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQ 4244
N +++ Q+ T P E QG L +++ + +E+ C +
Sbjct: 3938 IENHATDVHQAVKIGQSLSSLTSPAE---------QGVLSEKIDSLQARYSEIQDRCCRK 3988
Query: 4245 VAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGD 4304
A L+ L A + E E +VL L E+E K++ + Q +
Sbjct: 3989 AALLDQALSNARLFGEDEV------EVLN--------WLAEVEDKLSSVFVKDFKQDVLH 4034
Query: 4305 NGATQHEA--EALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVN 4362
H A E + + K V ++ Q +L++ E+ K + +
Sbjct: 4035 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTS 4094
Query: 4363 LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ 4422
L ++ R ++ + ++ L+ +E++ + + PQ+ Q + +
Sbjct: 4095 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 4154
Query: 4423 ESSASNQASSPENDVPDSILSP---QGQNG-DKWQYLHHELSSKIKLPLPQLVEPQVSTN 4478
E N+V ++L + + G DK +E + + Q V+ +
Sbjct: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
Query: 4479 MGILPSVTMYNFRYPTTEELKTYTTQLEDLR----QEASNLQTQENMTEEAYINLDKKLF 4534
+ E K L +R Q + LQ Q+ + + + D +
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD-SMD 4273
Query: 4535 ELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMT 4594
ELF S+ + E E + +E YE ++L + Y L ++ +L
Sbjct: 4274 ELFSHRSEIFGTCGE--EQKTVLQEKTESLIQQYEAISLLNSERYARL--ERAQVLVNQF 4329
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
W E ++ L +E T+ A + + S + R Q E+++L + + K
Sbjct: 4330 W---------ETYEELSPWIEETR-ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKP 4379
Query: 4655 SLQ---------QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYAL 4705
+ + LN G+ V E+ QKA+ +++ + A DE +
Sbjct: 4380 HIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEA------VSQ 4433
Query: 4706 LQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
++ + D ++ M L + L P + ++ D + + I K A L++
Sbjct: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE------CISDNKSATVELEK 4487
Query: 4766 TKSKVALQAQIENHKVFFQKLVA-DMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEE 4824
LQ E K ++L+ + +AK + L FW + ++
Sbjct: 4488 ------LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED-------IKA 4534
Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASL---EKDLEILISTLPSVSLVEETEERLVERISFY 4881
++ + +K +L+ E+F + A+L KD + ++ L S + ++ VE
Sbjct: 4535 RAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAA--- 4591
Query: 4882 QQIKRNIGGKHARLYQTLNEGKQLV---ASVSCPELEGQIAKLEEQWLSLNKKIDHELHR 4938
+ IK G H L G L+ PE+ I ++ W +LNK L +
Sbjct: 4592 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651
Query: 4939 LQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEV 4998
L+ ++ + Y + WL+++ L V DL+T++ +N EF EV
Sbjct: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP----VGTDLNTVKDQLNEMKEFKVEV 4707
Query: 4999 DEKSSLKTAVISIGNQLLH--LKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQM 5056
++ + G +L ETD +R L + + W L ++ Q KL +
Sbjct: 4708 YQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4767
Query: 5057 EKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVD 5116
+ A+ E++SW+ + E + + +V+ L KH + ++ Q V+
Sbjct: 4768 ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--LAKHHVLKNDVLAHQATVE 4825
Query: 5117 FVNQS---LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESIT 5173
VN++ LL+ S D S R E MN+ W V + Q L+ L+
Sbjct: 4826 TVNKAGNELLESSAGDDASSLRSRLE------AMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Query: 5174 ESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDC-QDIENQLAIKSKALDEL--K 5230
++I+ L E +L + + + LD ++ +QL K + ++L K
Sbjct: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
Query: 5231 QSYLTL---ESG-------AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
+ L +SG +V LLE + ++R S L + L T Q+ LQE+
Sbjct: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF- 4998
Query: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
+N +T+ + + P L L T+ Q+E + +E + +L +
Sbjct: 4999 --------INWLTLA-EQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 5049
Query: 5341 IGKLKGLCPSV-AEIIEEKCQNTHKRWTQVNQ-------AIADQLQKAQSLLQLWK 5388
+LK L +I+ + RW +V Q ++ D ++A+ + WK
Sbjct: 5050 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWK 5105
Score = 122 bits (305), Expect = 2e-26
Identities = 555/3237 (17%), Positives = 1235/3237 (38%), Gaps = 420/3237 (12%)
Query: 396 EAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHL 455
+AW+Q E +++ LS + V +QE++ K L + H
Sbjct: 2447 QAWMQACEANVEKLLSDTVASDPGV--LQEQLATTKQLQEELAEHQ-------------- 2490
Query: 456 PLVPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV 515
VP KL+++ R I I + H + V D + S ++ Y E
Sbjct: 2491 --VPVEKLQKVARDIMEIEGEP----APDHRH---VQETTDSILSHFQ--SLSYSLAERS 2539
Query: 516 ELLLEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCM------ 569
LL + + + L++ Q GE+ +NL G KQ + S V
Sbjct: 2540 SLLQK---AIAQSQSVQESLESLLQSIGEVEQNLEG------KQVSSLSSGVIQEALATN 2590
Query: 570 --YRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHAT 627
+++I KS+L+ ++E A + K E+ + + Q + ++
Sbjct: 2591 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2650
Query: 628 LNEAGNFLVEVSNDVVGSSISKELRR-LNKRWRKLVSKTQLEMNLP---LMIKKQDQPTF 683
L + + + +S +L++ + + R L S Q + ++ I++ +
Sbjct: 2651 LKKL------LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEME 2704
Query: 684 DNSGNILSKEEKATVEFSTDMSVELPENYN--QNIKAG----EKHEKENEEFTGQLKVAK 737
D N+ + E T S +++L ++ + QN++ +K KE E+ +
Sbjct: 2705 DQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQL 2764
Query: 738 D-VEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQ 796
D KL+ + W E + + + S +E K + S+ D+ ++ + +++ +
Sbjct: 2765 DEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCK 2824
Query: 797 NISSQESFQHVLTTGLQAKIQEAKEKVQINV--VKLIAALKNLTDVSPDL-DIRLKMEES 853
S + + Q K V +V V K+LT++ D+ D+ LK E+
Sbjct: 2825 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKL 2884
Query: 854 QKELESYMMRAQQLLGQRESPGELISKHKEA-LIISNTKSLAKYLKAVEELKNNVTEDIK 912
L Q +L + E HKEA ++ +S + LK+++ + + +
Sbjct: 2885 GGVLHERQESLQAILNRMEEV------HKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2938
Query: 913 MSLEEKSRDVCAKWESLHHELSLYVQQLK---IDIEKGKLSDNILKLEKQINKE-----K 964
+ E ++ A+ E ++ + L + + ++N K+++++N +
Sbjct: 2939 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2998
Query: 965 KLIRRGRTKGLIKEHEACFSEEGC-----LYQLNHHMEVLRELCEELPSQKSQ-QEVKRL 1018
+ R R H ACF L + M VL L + +Q Q+V+ +
Sbjct: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 3058
Query: 1019 LKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
LK++E + ++ H L A G G ++ S ++ + + Q
Sbjct: 3059 LKEFEARRQQ--------HEQLNEAAQGILTGPGDVSLSTSQ----------VQKELQSI 3100
Query: 1079 TEKAMEPTMKFSLAS------VLRPLQEESIMEKDYSASINSLLERYDTYRDI-LEHHLQ 1131
+K +E T K + S +++ Q + +++ D S + ++ +R I +
Sbjct: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ-DLSEKVRAVGQRLSVQSAISTQPEAV 3159
Query: 1132 NNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPF 1191
+ TS+ S+ ++ L ++ + Q + +E E + + +L+ + + P
Sbjct: 3160 KQQLEETSEIRSDLEQ----LDHEVKEAQTLCDELSVLIGE-QYLKDELKKRLETVALPL 3214
Query: 1192 VIKERDTLKERERELQMTLNT--RMESLETALRLVLPVEKASLLL-CGSDLPLHKMAIQG 1248
E D +R LQ L + + + + LR L +++ C L ++ Q
Sbjct: 3215 QGLE-DLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ- 3272
Query: 1249 FHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFD-LHAMQNIILKYKTQ 1307
Q Q S+ + + G +L + P + +QN +++ K
Sbjct: 3273 ---------LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNH 3323
Query: 1308 FEGMNHR-----------VQRS-------EDTLKALEDFLASLRTAKLSAEPVTDLSASD 1349
+E ++ + +Q++ ED + +ED A + +++ +PV S+
Sbjct: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
Query: 1350 TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK 1409
A N V+ + + ++ A L + + +D + G + + + + + K
Sbjct: 3384 RSKAMLNE--VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 3441
Query: 1410 LSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
G EE T+ + + FKN E K ++ + Q+ + K+ +K
Sbjct: 3442 T------GSLEEMTQRLREFQES-FKNIE--KKVEGAKHQLEIFDALGSQACSNKNLEK- 3491
Query: 1470 LIRLDKVLDEYEEEKRHLQEMANSLPH-FKDGREKT-VNQQCQNTVVLWENTKALVTECL 1527
L +VL E + +L+ L DG + + + Q + + K V
Sbjct: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
Query: 1528 EQCGRVLELLKQYQ-NFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE 1586
LE + Q+ + + + L ++ + + A ++L+ +I ++ + + +
Sbjct: 3552 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3611
Query: 1587 HLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALA 1646
++ C+++ L + T + ++E + + + E+ + E L L
Sbjct: 3612 LKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668
Query: 1647 LWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL----QVHEQKTSEFSRRVAE 1702
+ + +++ T A + L + + E + ++L +++ ++ +
Sbjct: 3669 RVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728
Query: 1703 I----QFLLQSSEIPLELQVMESSI---------LNKMEHVQKCLTGESNCHALSGSTAE 1749
+ Q L+QS+ ++Q +E + LNK + E+ H +
Sbjct: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC-----GK 3783
Query: 1750 LREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQ-----KHSMILLENQI 1804
++ L+ + + TE L+ P + K + +Q++LQ+ K ++ +L+ +
Sbjct: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
Query: 1805 GCL------------TPELSELKKQYESVSDLFNTKKSVLQDHF--SKLLNDQCKNFNDW 1850
G + T +L L+ ++ + ++ L+D +K ++ + +D+
Sbjct: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
Query: 1851 FSNIKVNLKECFE-SSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAH 1909
S + L ++T K +Q ++ + +E + + Q + + + A
Sbjct: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3963
Query: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
L + + +++ C +A L+ +L +D + WL E+K +
Sbjct: 3964 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 4023
Query: 1970 EEPGEKTELF----CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTL 2025
K ++ LA E ++ ++K ++ E + ++ +
Sbjct: 4024 FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083
Query: 2026 LRQLSEIE-EEDKLLPTEDQS------FNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
+ ++I K L T +Q+ F ++ W++E++E L +S G+ P E
Sbjct: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGE 4140
Query: 2079 RI----QKIKEIILLKPEGDARIETIMKQAESSEAPL----------VQKTLTDISNQWD 2124
+I Q+ KE+ E ++T+ E S A L + K ++D + Q+
Sbjct: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVN---EVSRALLELVPWRAREGLDKLVSDANEQYK 4197
Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKI 2184
+ + + ++Y Q+ + + E K+K A ++ + AQL++
Sbjct: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 4257
Query: 2185 YKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD-SVQN 2243
K F + EL S + + + EE ++ ESL+QQ + S+ N
Sbjct: 4258 QKAFSIDIIRHKDSMDELFSHRSEIFG-----TCGEEQKTVLQEKTESLIQQYEAISLLN 4312
Query: 2244 LDGHVREHDSYQVCVTDLNTTLDNFS------KEFVSFSDKP-VDQIAVEEKLQKLQELE 2296
+ + R + QV V T + S + ++ P +D + ++ +++++L
Sbjct: 4313 SERYARLERA-QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 4371
Query: 2297 NRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEME-- 2354
++ + K+L + +K+ G+ + + K + EN A K+E+
Sbjct: 4372 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE--------KYQKAENMYAQIKEEVRQR 4423
Query: 2355 --CCLNSILKSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
++ +S + TE K P E + +S ++ A V+K+ E NK +
Sbjct: 4424 ALALDEAVSQSTQITEFHDKIE-PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSAT 4482
Query: 2411 VEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK-- 2468
VE+ + + E++K +E + Q +L ++L+++ + ++A+
Sbjct: 4483 VELEKLQP----SFEALKRRGEEL-IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4537
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ IK L+ E K L Q + + L++ +++ E
Sbjct: 4538 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-------PGIDPSIIKQQVEA 4590
Query: 2529 LAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHV 2588
++ L + E +++ D + + +K + K D + N WENL+
Sbjct: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNNA---WENLNKTW 4645
Query: 2589 TDMDKKLLESQIKQLEHG------WEQVEQQIQKKYSQQVVEYDEFTTL--MNKVQDTEI 2640
+ +KL ++ +++ ++ ++ + K + V D T +N++++ ++
Sbjct: 4646 KERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV 4705
Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
+ QQQ ++ L Q EL +K+ E ++
Sbjct: 4706 EVYQQQIEMEK------------------------------LNHQGELMLKKATDETDRD 4735
Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKC-----DIRNKMKETILWAKNLLGELNPSIP 2755
+ + + LK WE L +++++ ++ ++E + W + L+ P
Sbjct: 4736 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4795
Query: 2756 LLPDDILSQIRKCK--VTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRN 2813
+ D + ++ K V + +LA Q +VE++ + + + S + S L + LE +
Sbjct: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855
Query: 2814 QYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAA---TEAEL 2870
++ ++ K+ +R QQL+ L++ F + I F L + E+ + T T E
Sbjct: 4856 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQ 4915
Query: 2871 KHHHVTLEASQKELQEI----------------DSGISTHLQELTNIYEELNVFERLFLE 2914
H+ L + K +E DSG + ++ + E+ +E
Sbjct: 4916 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
Query: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSA----LQEEADSIQRNELLLN 2970
++ L+ N F QN+ E + + Q S L I+ +++ N
Sbjct: 4976 ERKSKLEEALNLATEF-QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
Query: 2971 QEVNKGVKEEIYNLKDRLTAIKCCILQ--VLKLKKVFDYIGLNWDFSQLDQLQTQVFEKE 3028
EVN +++I L +K + V+ +K + + W+ ++ + E+
Sbjct: 5035 -EVNAH-RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE-----KVVQRSIERG 5087
Query: 3029 KELEEKIKQLDTFEEEHGKYQALLSKMRA--------------IDLQIKKMTEVVLKAPD 3074
+ L++ K+ F E K L + I LQ+ K E
Sbjct: 5088 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 5147
Query: 3075 SSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLY 3134
P + I + R K K L E +KL+ F ++K + E KL
Sbjct: 5148 KQPV---YDTTIRTGRALKEKTLLPEDSQKLDN---FLGEVRDKWDTVCGKSVERQHKLE 5201
Query: 3135 KVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEA 3194
+ L L D L+ + L +++ QL + ++ ++ + N D +
Sbjct: 5202 EAL-----------LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
Query: 3195 FQEQVWAEMCSIKAVTAIEKQREENS-SEASDVETKLREFE---DLQMQLNTSIDLRTNV 3250
FQ+++ +++ + ++ ENS + + V+ +L+E D +L+ S R
Sbjct: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR--- 5307
Query: 3251 LNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP-------LRKQEEL 3303
L A + +++ V +E ++ E + +R + + E+L+ ++K EE
Sbjct: 5308 LEQALKQAEVFRDTVHMLLEWLSEAEQ-TLRFRGALPDDTEALQSLIDTHKEFMKKVEEK 5366
Query: 3304 ESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC 3363
V + E + + P+ +++ + + ++ + K + E L
Sbjct: 5367 RVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 5426
Query: 3364 YRKMEEDIYTNLSKMETVLGQ-SMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
++ E++ + ET L Q +P + +++ KAL++ + EE+ +
Sbjct: 5427 NAELLEELLAWIQWAETTLIQRDQEPIP-------QNIDRVKALIAEHQTFMEEMTR 5476
Score = 118 bits (296), Expect = 2e-25
Identities = 582/3197 (18%), Positives = 1209/3197 (37%), Gaps = 490/3197 (15%)
Query: 975 LIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKS--QQEVKRLLKDYEQKIERLLKC 1032
++K+ E F EE + LRE + Q Q+E + K+ E+ + L+
Sbjct: 2111 VVKDIEG-FMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQ 2169
Query: 1033 ASEIHMTLQPTAGGTSKNEGT---ITTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKF 1089
+E + A K + +T+ + GG + P + + S EK T
Sbjct: 2170 ETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229
Query: 1090 SLASVLRP--LQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDR 1147
+ P L ++ M K + S + + + L + +T +
Sbjct: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE------- 2282
Query: 1148 SSSCLQAKLTDLQVIKN----ETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERE 1203
LQ KL +L+ + +++A K+ + + +L+ + D K+ L+ E
Sbjct: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE-----FESWLERSE 2337
Query: 1204 RELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRN 1263
+EL+ ++ S ET L+ S + L + I G ++D + ++ +
Sbjct: 2338 KELE-NMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 2396
Query: 1264 IQDSIAKQIEICNRLEEPGNFVLKELHPFD-----LHAMQNIILKYKTQFEGMNHRVQRS 1318
E GN V +L LH+ + + G H+ Q S
Sbjct: 2397 PS--------------EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 2442
Query: 1319 EDTLKALEDFLASLRTAKLSAEPV-TDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHL 1377
D+L+A ++ + + E + +D ASD V QE T K + E+ + + L
Sbjct: 2443 ADSLQAW------MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 2496
Query: 1378 DKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNN 1437
K + + M + D + D+ +H + E + LL+ I ++
Sbjct: 2497 QKVARDI-MEIEGEPAPDHRHVQETTDSIL-----SHFQSLSYSLAERSSLLQKAIAQSQ 2550
Query: 1438 ELLKNIQDVQSQISKI--GLKDPTVPAVKHR--KKSLIRLDKVLDEYEEEKRHLQEMANS 1493
+ ++++ + I ++ L+ V ++ +++L K+ + +K L+
Sbjct: 2551 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2610
Query: 1494 LPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQK 1553
+ F + + T T + + A V++ EQ L Q Q +S L L+ +
Sbjct: 2611 VTRFMETADST-------TAAVLQGKLAEVSQRFEQ------LCLQQQEKESSLKKLLPQ 2657
Query: 1554 EESVISLQASYMG-KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
E L EN + +A ++ + + ++N ++ Q
Sbjct: 2658 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ---------- 2707
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
LD E + G AL L ++N+ ++TE LQK
Sbjct: 2708 -------------ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTE--LQKTVKE 2752
Query: 1673 QLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQK 1732
+ E+D +E+L + F + + E + + +E + + +E I EH++
Sbjct: 2753 R--EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQI----EHLKS 2806
Query: 1733 CLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSL-EIFTKLEEIQQQI- 1790
L + S L E+++ T + E+L+ ++ DS + + L + +
Sbjct: 2807 LLDDWA-------SKGTLVEEINCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVG 2856
Query: 1791 -LQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL--LNDQCKNF 1847
+ H+ L +I C ++S++ +YE + + + ++ LQ +++ ++ + +
Sbjct: 2857 SVNGYHTCKDL-TEIQC---DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
Query: 1848 NDWFSNIKVNLKECFESSETKKSVEQKLQKLSD--FLT-LEGRNSKIKQVDSVLKHVKKH 1904
W + + LK S K+ K Q S+ FL LE + KI++V L +
Sbjct: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972
Query: 1905 LPKAHVKELISWLVGQEFEL----EKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLT 1960
P + E +W QE EL E+ + AR ++LE+S L Q LR WL
Sbjct: 2973 YPNSQEAE--NWKKIQE-ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 3029
Query: 1961 NQEEKWKGMEEP-----------GEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEE 2009
++E G+ P ++ + + +R+Q E QLN + + T
Sbjct: 3030 -EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE---QLNEAAQGI-LTGPG 3084
Query: 2010 EIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQ---------SFNDLAHDVIHWIKEI 2060
++ + + + Q++ ++ +E DKL Q + +L D+ ++ +
Sbjct: 3085 DVSLSTSQVQKELQSINQKW--VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 3142
Query: 2061 KESLMVLN---------------SSEGKMPLEERIQKIKEIILLKPEGDARI-ETIMKQA 2104
+ L V + +SE + LE+ ++KE L E I E +K
Sbjct: 3143 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
Query: 2105 ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKK 2164
++K L ++ LA+ ++ + L +++ Q ++LR L + + +
Sbjct: 3203 -------LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 3255
Query: 2165 QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECT---KNPSFSEE 2221
Q + L+ ++QL+ ++F K + + + ++G LL + +
Sbjct: 3256 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 3315
Query: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVD 2281
+E+K+ E L ++ D L +++ YQ V DL +++ K +S +D
Sbjct: 3316 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED-CKAKMSELRVTLD 3374
Query: 2282 QIAVEEKLQK----LQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD------ 2331
+ +E L + L E+E R SL + IL A + N+S + I+D+
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLE-----ILNSAADILINSSEADEDGIRDEKAGINQ 3429
Query: 2332 ----------------------IKSLQCKQKDLENRLASAKQEME--------CCLNSIL 2361
++ Q K++E ++ AK ++E C N L
Sbjct: 3430 NMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL 3489
Query: 2362 KSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQL 2419
+ R+ ++ + P + + T + E + + +L E+ + +E+ KQ
Sbjct: 3490 EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV---KQR 3546
Query: 2420 SLNAQESMKNT-----EDERKVNELQNQPLELDTML------------RNEQLEEIEKLY 2462
+ M+N + +V E+ +Q +LD L Q+E++
Sbjct: 3547 VNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFL 3606
Query: 2463 TQLEAKKAAIKPLEQTECLNK-TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
++ K I+ E EC + E G L L + + L+ L K ++ Q +
Sbjct: 3607 NKIHVLKLDIEASE-AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLEL 3665
Query: 2522 ----LRDFQEYLAAVESSMKALLTDKESLK--VGPLDSVTYLDKIKKFIASIEK-EKDSL 2574
+ DF L + + A + E+L+ VG T ++ I + +A + +K+ +
Sbjct: 3666 TLGRVEDFYRKLKGLNDATTA-AEEAEALQWVVG-----TEVEIINQQLADFKMFQKEQV 3719
Query: 2575 GNLKIKWENLSNHVTDMDKKLLES-----QIKQLEHGWEQVEQQ---IQKKYSQQVVEYD 2626
L++K + V + + L++S ++ LEH E++ + + KK +Q++ +
Sbjct: 3720 DPLQMKLQ----QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3775
Query: 2627 EFTTLMNKVQDT---EISLQQQQQHLQLRLKSPEE-----RAGNQSMIALTTDLQATKHG 2678
E K QD +S + L K P +A Q L L K
Sbjct: 3776 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3835
Query: 2679 FSVLKGQ-AELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMK 2737
+L+ + + ++EK + + +L+ +W L + K R K
Sbjct: 3836 VDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTEL----------LSKAAARQKQL 3883
Query: 2738 ETIL-WAKNLLGELNPSIPLL---------PDDILSQIRKCKVTHDGILARQQSVESLAE 2787
E IL AK P L + + +Q K + A ++ +E+ A
Sbjct: 3884 EDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHAT 3943
Query: 2788 EVKDKV------PSLTT-YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
+V V SLT+ E L+ ++ L+ +Y + + +++ L+ L F
Sbjct: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 4003
Query: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
+ + E E + + L H A +E+ + ++
Sbjct: 4004 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 4063
Query: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEAD 2960
+ ++ E L ++++L +K R I T ++ ++ RQ K + EE
Sbjct: 4064 LLKQTTGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLATKFQSTYEELT 4119
Query: 2961 SIQR--NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIG--------- 3009
R E L E+I + R +K +V++ + V D +
Sbjct: 4120 GWLREVEEELATSGGQSPTGEQIPQFQQRQKELK---KEVMEHRLVLDTVNEVSRALLEL 4176
Query: 3010 LNWDFSQ-LDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEV 3068
+ W + LD+L + E+ K + + I Q +E Q +A D ++ + E
Sbjct: 4177 VPWRAREGLDKLVSDANEQYKLVSDTIGQ--RVDEIDAAIQRSQQYEQAADAELAWVAET 4234
Query: 3069 VLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAE 3128
K P RL + +++ K +II+ + D+ F + + E
Sbjct: 4235 KRKLMALGP--IRLEQDQTTAQLQVQKAFSIDIIR---HKDSMDELFSHRSEIFGTCGEE 4289
Query: 3129 ENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQ-----------------IKSQ 3171
+ L + ++++ + L +LE + ++NQ + +Q
Sbjct: 4290 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ 4349
Query: 3172 LQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQ-REENSSEASDVETKL 3230
L P ++ + ++ +++ +E + I + I Q +E N E VE K
Sbjct: 4350 LPSPA---IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY 4406
Query: 3231 REFEDLQMQLNTSIDLRTNVLNDAYE---NLTRYKEAVTRAVESITSLEA-----IIIPY 3282
++ E++ Q+ + R L++A +T + + + +E++ +L + +IP
Sbjct: 4407 QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA 4466
Query: 3283 RVD------VGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQEL 3336
VD N ++E+ E+L+ + ++ E+L S K +Q+
Sbjct: 4467 EVDKIRECISDNKSATVEL-----EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
Query: 3337 VSKNSAMKEAFKAQETEAE-RYLENYKCYRKMEEDIYTNLSKMETV--LGQSMSSLPLSY 3393
+ + E KA+ E E ++L+ + K D+ L+ ++ + + S +
Sbjct: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581
Query: 3394 REALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSL 3453
+++E ++ + EEL +R + L C E + + K + + W +L
Sbjct: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4641
Query: 3454 LEAAKEWEMWCEELKQEWKFVSEEIEREAIILDN-----------------LQEELPEIS 3496
+ KE E+ Q + ++ LDN ++++L E+
Sbjct: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMK 4701
Query: 3497 KTK-----EAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPES------- 3544
+ K + E+L+ + + + + + ++ L + +N+ E
Sbjct: 4702 EFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHK 4761
Query: 3545 -SGAVETVPAFQ----EITSMKERCNKLL---QKVQKNKELVQTEIQERHSFTKEIIALK 3596
GA+ + FQ E+ S +LL + + + ++++ E+ + H +++A
Sbjct: 4762 LEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA-- 4819
Query: 3597 NFFQQTTTSFQNMAFQDHPEKS--EQFEELQSILKKGKLTFENIMEKLRIKYSEMY-TIV 3653
Q T N A + E S + L+S L+ +E++++K + ++ T+
Sbjct: 4820 ---HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQ 4876
Query: 3654 PAE-IESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
A+ S++E+ L ++ ++S R +++ ++E Q K+K
Sbjct: 4877 QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT------HMELYSQLKAK- 4929
Query: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
+E ++ D+ + + D G + ++ + Q++ VS +
Sbjct: 4930 ----EETYNQLLDK------------GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4973
Query: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALE 3832
E R S+L +A E+ + L+ W+ L N A SL +TV +E
Sbjct: 4974 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSL-----ILNTVLSQIE 5027
Query: 3833 DSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDV 3892
+ H +F + + D++ + + + NQ+ L QK DV
Sbjct: 5028 E--------HKVFAN----EVNAHRDQIIE-LDQTGNQLKFLSQK------------QDV 5062
Query: 3893 VAIESEVKSMEKRVSKI 3909
V I++ + S++ R K+
Sbjct: 5063 VLIKNLLVSVQSRWEKV 5079
Score = 115 bits (288), Expect = 2e-24
Identities = 496/2763 (17%), Positives = 1051/2763 (38%), Gaps = 318/2763 (11%)
Query: 1475 KVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVL 1534
++L E++ ++LQ+ +S+ + R QN V + E TK L + + GR+
Sbjct: 1879 QLLKALEKDAKNLQKSLSSVSDTWNSRLL----HFQNAVEI-EKTKVL-NQHTQLEGRLQ 1932
Query: 1535 ELLKQYQNFKSILTTLIQKEE-SVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDK 1593
+L N IL + E V SL E+LK+ +AE + +
Sbjct: 1933 DLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA-------------Q 1979
Query: 1594 INQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLF- 1652
++ + ++QF++++ P ++ + +NE + + L + A D L
Sbjct: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRL------LNELQRSFQDILEQTAAQVDALQG 2033
Query: 1653 NLKNVIDEWTEKALQKME--LHQLTEEDRE---RLKEELQVHEQKTSEFSRRVAEIQFLL 1707
+L+ + E K LQK + HQ E+ + + L H+ +T++ Q L
Sbjct: 2034 HLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQ--------QDLS 2085
Query: 1708 QSSEIPLELQVMESSILNKMEH---VQKCLTG--ESNCHALSG-STAELREDLDQAKTQI 1761
+ +L+ ++ I N+ V K + G E N LS LRE L QAK Q
Sbjct: 2086 ALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY 2145
Query: 1762 GMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESV 1821
+ + +LEE LQQ E + EL+E KK+ +++
Sbjct: 2146 EALQEETRVAQK--------ELEEAVTSALQQ-------ETEKSKAAKELAENKKKIDAL 2190
Query: 1822 SDLFNTKKSVLQDHFSKL----------LNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
D + S + L L + D + + ++ + E K+
Sbjct: 2191 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 2250
Query: 1872 EQKL--QKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKEL----ISWLVGQEFELE 1925
Q+L Q+ + L + + + Q L ++ + + + EL + L E EL+
Sbjct: 2251 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK 2310
Query: 1926 KMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALAR 1985
++++ L+D LQ+ L+ DH+ WL E++ + M + G E L R
Sbjct: 2311 QVQT--------LQDELQKFLQ---DHKEFESWLERSEKELENMHKGGSSPETLPSLLKR 2359
Query: 1986 KREQFE-----------------SVAQLNNSLKEYGFTEE-----EEIIMEATCLMDRYQ 2023
+ E V + NS KE E ++ + +AT +RY
Sbjct: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDAT---ERYT 2416
Query: 2024 TLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESL-MVLNSSEGKMP--LEERI 2080
L + + + +L + F + A + W++ + ++ +L+ + P L+E++
Sbjct: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
Query: 2081 QKIKEIILLKPEGDARIETIMKQA------ESSEAP---LVQKTLTDISNQWDNTLHLAS 2131
K++ E +E + K A E AP VQ+T I + + + + +
Sbjct: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG--FALQHG-LQEKKAQLKIYKKF 2188
S +K + + + +S E L + E+++ E +L G +QE A K+
Sbjct: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
Query: 2189 LKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHV 2248
+ + + +E+ ++ + T + + E+ E L Q Q+ +L +
Sbjct: 2597 IARQKSSLEATREMVTRFMETADST-TAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2655
Query: 2249 REHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKK 2308
+ + ++ L ++N S+ S + D + Q++QEL + Q L
Sbjct: 2656 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQD---ITHFFQQIQELNLEMEDQQENLDT 2712
Query: 2309 ILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECC---LNSILKSKR 2365
+ L + ++ +D +++L+ +L+ + +++ C L+ K R
Sbjct: 2713 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2772
Query: 2366 STEKKGKFTLPGREKQATS-DVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSL-NA 2423
+ +K K T TS +E ++ ++ L +DW +K + VE K SL N
Sbjct: 2773 TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW-ASKGTLVEEINCKGTSLENL 2831
Query: 2424 QESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNK 2483
+ + + K + + + +T K + ++ K
Sbjct: 2832 IMEITAPDSQGKTGSILPSV--------GSSVGSVNGYHT---CKDLTEIQCDMSDVNLK 2880
Query: 2484 TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDK 2543
E VLH + L +L + + K S L +E L ++++ T
Sbjct: 2881 YEKLGGVLHE---RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP--TKT 2935
Query: 2544 ESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKI---------KWENLSNHVTDMDKK 2594
E++K + +L ++++ I+K K++L L + W+ + + ++
Sbjct: 2936 ETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWER 2995
Query: 2595 LLESQI---KQLEHGWEQVE--QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHL 2649
E + +QLE + Q + + ++E + ++ + L Q+Q +
Sbjct: 2996 ATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQV 3055
Query: 2650 QLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNL 2709
Q LK E R Q + +L G ++ + +KE + ++
Sbjct: 3056 QFMLKEFEARRQQHE--------QLNEAAQGILTGPGDVSLSTSQVQKE-------LQSI 3100
Query: 2710 KKQWETLEPLHLEAENQIKKCDIRNKMKETILW-------AKNLLGELNPSIPLLPDDIL 2762
++W L +QI + +++ + +L A + +I P+ +
Sbjct: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 3160
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSL--TTYEGSDLNNTLEDLRNQYQMLVL 2820
Q+ + + V+ A+ + D++ L Y +L LE + Q L
Sbjct: 3161 QQLEETSEIRSDLEQLDHEVKE-AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLED 3219
Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
+ R +L+ L A ++FQ M E T + + A + L++
Sbjct: 3220 LAADRINRLQAAL-------ASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 3272
Query: 2881 QKELQEIDSGISTHLQELTNIYEE-----LNV---FERLFLEDQLKNLK----------- 2921
+E +E ++ H I E L+V E+ L++QL LK
Sbjct: 3273 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTA 3332
Query: 2922 IRTNRIQRFIQNTCN---EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVK 2978
R +R++ +Q VE + + K S L+ D +Q LL +K +
Sbjct: 3333 DRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLR---SKAML 3389
Query: 2979 EEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFE----KEKELEEK 3034
E+ + L + +L D G+ + + ++Q V E K LEE
Sbjct: 3390 NEVEKRRSLLEILNSA-ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEM 3448
Query: 3035 IKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKA 3094
++L F+E ++ + K+ Q++ + +A + + Q + Q +E
Sbjct: 3449 TQRLREFQE---SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQ 3505
Query: 3095 KCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQN--MVLELSPKELDEK 3152
+ L E+ D S + + Q ++ +E ++ + + + +++E + + +
Sbjct: 3506 VDYLRNFTQGLVEDAP-DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564
Query: 3153 NCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAI 3212
+C ++ L + +L I + +Q++ ++ F ++ I+A A
Sbjct: 3565 HC--RVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE 3622
Query: 3213 EKQREENSSEASDVETKLREFEDLQMQL----------NTSIDLRTNVLNDAYENLTRYK 3262
+ E + K RE E L Q ++L + D Y L
Sbjct: 3623 CRHMLEEEGTLDLLGLK-RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681
Query: 3263 EAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQ--EELESTVAHIQDLTEKLG 3318
+A T A E+ EA+ ++ V++ N + + +K+ + L+ + + L + L
Sbjct: 3682 DATTAAEEA----EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLI 3737
Query: 3319 MISSPEAKLQ-LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSK 3377
+ + +Q L++ ++E+ ++ + + + + + + L + ++ E + + L+
Sbjct: 3738 QSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD 3797
Query: 3378 METVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGI 3437
E ++ + Y+ ++++ K L L K + L+ + D
Sbjct: 3798 TEELIA-NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE 3856
Query: 3438 CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISK 3497
+ + +L +W LL A + E++ K E E I D L +++
Sbjct: 3857 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP---ISDFLSVTEKKLAN 3913
Query: 3498 TKEAAT-TEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQE 3556
++ T T ++ + + E++E T + Q ++ Q++ + E ++
Sbjct: 3914 SEPVGTQTAKIQQQIIRHKALEEDIENH---ATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3970
Query: 3557 ITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSF---------Q 3607
I S++ R +++ + + L+ + F ++ + + N+ + Q
Sbjct: 3971 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 4030
Query: 3608 NMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKA 3667
++ + H + EE+ + K +N L+ E + I+ +++ +
Sbjct: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLL----IQEKLDGIKTR 4086
Query: 3668 LEDIDEKISNEVLKSSPSYAMRRKI----EEINNGLHNVEKML------QQKSKNIEKAQ 3717
DI S + + + K EE+ L VE+ L + I + Q
Sbjct: 4087 YADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ 4146
Query: 3718 EIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF-QQYQQVSQRAECR 3776
+ QK++ E+ L+ ++ + ++E P +A+E +D L+ +QY+ VS R
Sbjct: 4147 QRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQR 4206
Query: 3777 TSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQ 3836
+++ A + ++Y + AW+ T L L +T Q+ ++ +
Sbjct: 4207 VDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI----RLEQDQTTAQLQVQKAFS 4262
Query: 3837 KHNLLHSIFMD--LEDLSIIFET---------DELTQSIQELSNQVTALQQKIMESLPQI 3885
+ H MD S IF T E T+S+ + ++ L + L +
Sbjct: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 4322
Query: 3886 QRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIA 3945
Q + + E+ + + L S I + + + E+I K I
Sbjct: 4323 QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 4382
Query: 3946 EIVSYQVELR--LPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQT--NEW 4001
+++ +L+ P+ G +Q+ + IK E V Q L + V + T E+
Sbjct: 4383 KLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK--EEVRQRALALDEAVSQSTQITEF 4440
Query: 4002 DEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-------EIERMEKQILSLNQRKE 4054
++IE + + L N S++ + + P + DK+ + E+E+++ +L +R E
Sbjct: 4441 HDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGE 4500
Query: 4055 DLL 4057
+L+
Sbjct: 4501 ELI 4503
Score = 108 bits (269), Expect = 2e-22
Identities = 158/821 (19%), Positives = 326/821 (39%), Gaps = 59/821 (7%)
Query: 4667 SVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYA--------LLQEVYKLEDVLDS 4718
+V +QL + + VE+ + + KL +GE L L A + + + +L+ + ++
Sbjct: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE-LMLKKATDETDRDIIREPLTELKHLWEN 4750
Query: 4719 MWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIEN 4778
+ + R +L + Q L+ ++ + +E L KV ++ ++
Sbjct: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV-IEVELAK 4809
Query: 4779 HKVFFQKLVADMLLIQAYS--------------AKILPSLLQNRETFWAEQVTEVKILEE 4824
H V ++A ++ + A L S L+ W + + EE
Sbjct: 4810 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT---EE 4866
Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQI 4884
+ +Q LQ E ++ L + L ++ P+ L E E+L + Y Q+
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926
Query: 4885 KRNIGGKHARLYQTLNEGKQLVA----SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
K K Q L++G+ ++ S S + E +A LE++W ++ K++ +L+
Sbjct: 4927 K----AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
L + + WL ++ +LN SL L+T+ S I F+ EV+
Sbjct: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL----ILNTVLSQIEEHKVFANEVNA 5038
Query: 5001 KSSLKTAVISIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
+ GNQL L ++ D ++ L + +W ++ + + L +
Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098
Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF-- 5117
+A ++I W+ + E E + + ++K L KHKEF+ + KQ + D
Sbjct: 5099 QFHEAWKKLIDWLEDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156
Query: 5118 -VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
++L + + +S++ + LGE+ +W V G + LE+ L +
Sbjct: 5157 RTGRALKEKTLLPEDSQKLD-----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 5211
Query: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDI-ENQLAIKSKALDELKQSYLT 5235
+ +Q L +WL E +L Q + + L+D + + +L ++ + LK+S
Sbjct: 5212 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRE 5271
Query: 5236 LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIR 5295
L + D + + Q+ S+ V +L S QS L++ +++ + M +
Sbjct: 5272 LIENS----RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
Query: 5296 FWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEII 5355
+ + ++ + L E LQSL D + E+ + + + + +
Sbjct: 5328 W---LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 5384
Query: 5356 EEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS 5415
C T K W + +A +++ Q + + A A L ++ + Q A +
Sbjct: 5385 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 5444
Query: 5416 MSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
+ + E +P + +K L + Q E + +DR+
Sbjct: 5445 LIQRD-QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484
Score = 105 bits (263), Expect = 1e-21
Identities = 377/2035 (18%), Positives = 792/2035 (38%), Gaps = 291/2035 (14%)
Query: 4496 EELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLS--SVEEMLEM 4553
+ L Q EDL+Q + + Q LD F++ +S+ S ++ +M
Sbjct: 1957 DSLNLCLQQYEDLKQPMAERKAQ----------LDALAFDIQFFISEHAQDLSPQQNRQM 2006
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ-V 4612
RL E Q E A ++ L L + + L +NT C L+ +
Sbjct: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT-----CHQQLEDL 2061
Query: 4613 CL---EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG---- 4665
C + +A A + ++ + L + Q+++K L + TS + +I G
Sbjct: 2062 CSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEE 2121
Query: 4666 ----------QSVAEQLQKADAYTVELENAESRVAK----------LRDEGERLHLPYAL 4705
++ E+L +A L+ E+RVA+ L+ E E+ L
Sbjct: 2122 NQTKLSPRELTALREKLHQAKEQYEALQE-ETRVAQKELEEAVTSALQQETEKSKAAKEL 2180
Query: 4706 LQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA----HG 4761
+ K++ +LD W ++S + Q L GM +L EK A G
Sbjct: 2181 AENKKKIDALLD--W---------VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229
Query: 4762 HLKQTKSKVALQAQIENHKVFFQKLVADM--LLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
++ ++ L Q E K Q+L++ ++ SA+ + T +Q+ +
Sbjct: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQ 2289
Query: 4820 KILEEKSRQCGM----------------KLQSLLQKWEEFDENYASLEKDLEIL------ 4857
K+ E K + +LQ LQ +EF+ EK+LE +
Sbjct: 2290 KLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSS 2349
Query: 4858 ISTLPSVSLVEETEERLVERISFYQQIKRNI---GGKHARLYQTLNEGKQLVASVSCPEL 4914
TLPS+ + + E + ++ R + G K + + EGK+ S +
Sbjct: 2350 PETLPSLL---KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE--PSEIGNLV 2404
Query: 4915 EGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQS 4974
+ ++ E++ +L+ K L LL + +D L W+++ + N K S
Sbjct: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE--ANVEKLLS 2462
Query: 4975 LNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLL-----------HLKETDT 5023
V+ D ++ + + +E+ E + + ++ H++ET
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
Query: 5024 A------TLRASLAQFEQKWTMLITQLPDIQEKLHQL-----QMEKLPSRKAITEMISWM 5072
+ +L SLA+ I Q +QE L L ++E+ K ++ + S +
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
Query: 5073 NNVEHQTS---DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCD 5129
T+ +D SS + ++ + E D ++LQ +
Sbjct: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFME----------TADSTTAAVLQGKLAE 2632
Query: 5130 VESK-------RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLES-------ITES 5175
V + + E+ + L + + G L + +++ ++L S IT
Sbjct: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692
Query: 5176 ENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELKQSYL 5234
+IQ LN +E Q+E L TL+ + +S LD CQ + + L++ +
Sbjct: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR--------VQNLRKDFT 2744
Query: 5235 TLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTI 5294
L+ +D +S ++L + R V T LK + S+ E +M
Sbjct: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP---------TETSMSAK 2795
Query: 5295 RFWYCMEHSKPVV-------LSLETLRCQVENLQSLQDE--AESSEGSWEKLQEVIGKLK 5345
+EH K ++ +E + C+ +L++L E A S+G + +G
Sbjct: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855
Query: 5346 G------LCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAA 5399
G C + E I+ + + ++ ++ + ++ + Q++L H EA +
Sbjct: 2856 GSVNGYHTCKDLTE-IQCDMSDVNLKYEKLGGVLHERQESLQAIL---NRMEEVHKEANS 2911
Query: 5400 RLKQQEAKFQQLANI-SMSGNNLAEILPPA-------LQDIKELQHDVQKTKEAFLQNSS 5451
L+ E+K + L ++ +MS E + L ++++ +QK KEA +
Sbjct: 2912 VLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL---AG 2968
Query: 5452 VLDRLPQPAESSTHMLLPGPLHS-LQRAAYL----EKMLLVKANE---FEFVLSQFKDFG 5503
+L P E+ + L+S +RA + ++ L A+ F+ SQ + +
Sbjct: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 3028
Query: 5504 VRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-------- 5555
+ E + G++ + + L+ Q K+ L A Q E LNE +
Sbjct: 3029 MEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQH---EQLNEAAQGILTGPG 3084
Query: 5556 -LKLPLSDVAVKTLQNMNRQWIRATATALERCSEL-QGIGLNEKFLYCCEKWIQLLEKIE 5613
+ L S V K LQ++N++W+ T R S++ Q I + ++ + + + +
Sbjct: 3085 DVSLSTSQVQ-KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
Query: 5614 EALKVDVA-NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI- 5671
+ L V A ++ PE ++QQ +E+ + D V ++ L D + +++
Sbjct: 3144 QRLSVQSAISTQPEAVKQQLEE---TSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
Query: 5672 TEFSKLTDRWQNAVQGVRQRKGD----VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
E K + +QG+ D + + Q F + L +L D A
Sbjct: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL-DDKQSQQAKN 3259
Query: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDL-KTKESVGRRISQ 5786
L + +S + E + + + + + + GE LLL+ + K ++ ++ +
Sbjct: 3260 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 3319
Query: 5787 LQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSE------DPLPEL 5840
L++ W+++ + A+ + + ++ + + +++L ++ KA+ DP+ +L
Sbjct: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QL 3378
Query: 5841 HEDLHNEKELIKELEQ---------SLASWTQNLKE-----LQTMKADLTRHV--LVEDV 5884
L K ++ E+E+ S A N E ++ KA + +++ + E++
Sbjct: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 3438
Query: 5885 MVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTA 5944
+E + ++ + ++++E + +F+ + C+ NK L+
Sbjct: 3439 QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS------NKNLEKL 3492
Query: 5945 DISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-----EIDDKLNKI 5999
+E+++ L+ ++ + F++ ++ G + +++ A E+ ++N
Sbjct: 3493 RAQ-QEVLQALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSG 3550
Query: 6000 NDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEI 6059
++ + IG +++E F+ + LD + + + R L + +++
Sbjct: 3551 CVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA-IGRDTDSLQSQI-------EDV 3602
Query: 6060 QKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRN 6119
+ L + L+ DIE A C +L + + +++ +L+++
Sbjct: 3603 RLFLNKIHVLKLDIEASEAE-------CRHMLEEE----GTLDLLGLKRELEALNKQCGK 3651
Query: 6120 ICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRF 6179
+ R+ ++E T + F D +AE A ++L F
Sbjct: 3652 LTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADF 3711
Query: 6180 EAFQR-QIHERLTQLELINKQYRRLARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAVL 6237
+ FQ+ Q+ +L+ +N + L + D L+ + E N RW+ L ++V +
Sbjct: 3712 KMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRI 3771
Query: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI---T 6294
+L+ +F+ E +L WL + + + N + A+ K+ + +Q++
Sbjct: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRL 3828
Query: 6295 LNTNK--IDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
L+ K +D L G ++ Q +E D I +LE L E+ + + ++L
Sbjct: 3829 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883
Score = 101 bits (251), Expect = 3e-20
Identities = 582/3278 (17%), Positives = 1245/3278 (37%), Gaps = 498/3278 (15%)
Query: 813 QAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRE 872
Q+ +++ ++ +Q +K++ + +L S +EL + + Q Q E
Sbjct: 2091 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL----SPRELTALREKLHQAKEQYE 2146
Query: 873 SPGE---LISKHKEALIISNTKSLAKYLKAVEELKNNVTE-----DIKMSLEEKSRDVCA 924
+ E + K E + S + + KA +EL N + D S+ +
Sbjct: 2147 ALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
Query: 925 KWESLHHELSLYVQQLKIDIEKGKLSDNIL--KLEKQINKEKKLIRRGRTKGLIKEHE-- 980
+ +++ +D G + N KL+KQ K R + L+ + +
Sbjct: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMK-----ARHQELLSQQQNF 2261
Query: 981 --ACFSEEGCLYQLNHHM---------EVLRELCEELPSQKSQQEVK-RLLKDYEQKIER 1028
A S + L Q H++ + L EL E+ + +Q E + + ++ + ++++
Sbjct: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK 2321
Query: 1029 LLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK-AMEPTM 1087
L+ E L+ ++E + G P + K S + + + +
Sbjct: 2322 FLQDHKEFESWLE-------RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDL 2374
Query: 1088 KFSLASVLRPLQ-EESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEED 1146
+F S + L E S E + I +L++ D +D E + + S+
Sbjct: 2375 RFVTISGQKVLDMENSFKEGKEPSEIGNLVK--DKLKDATERY---------TALHSKCT 2423
Query: 1147 RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDI--KKPFVIKERDTLKERER 1204
R S L L +N D+ + +E ++D P V++E+ ++ +
Sbjct: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
Query: 1205 ELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNI 1264
E +E L+ R ++ +E G P H+ + D I H +++
Sbjct: 2484 EELAEHQVPVEKLQKVARDIMEIE-------GEPAPDHRHVQE-----TTDSILSHFQSL 2531
Query: 1265 QDSIAKQIEICNRLEEPGNFVLKELHPF---------DLHAMQ------NIILKYKTQFE 1309
S+A++ + + V + L +L Q +I +
Sbjct: 2532 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2591
Query: 1310 GMNHRVQRSEDTLKALEDFLAS-LRTAKLSAEPVTDLSASDTQVAQE-NTLTVKNKEGEI 1367
+ + R + +L+A + + + TA + V L +V+Q L ++ +E E
Sbjct: 2592 KLKQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKES 2649
Query: 1368 HLMK-----DKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEF 1422
L K + +HL L+ M K + + F ++ E + ++ E
Sbjct: 2650 SLKKLLPQAEMFEHLSGKLQQF-MENKSRMLASGNQPDQDITHFFQQIQELN---LEMED 2705
Query: 1423 TEEN--------KLLEACIF-----KNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
+EN L +C F ++ + ++N++ +++ K VK R+K
Sbjct: 2706 QQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK---------TVKEREKD 2756
Query: 1470 LIRLDKVLDEYEEEKRHLQ----EMANSLPHFKDGRE-KTVNQQCQNTVVLWEN--TKAL 1522
+ LDE+ + R Q E S+P + K + +Q ++ L ++ +K
Sbjct: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2816
Query: 1523 VTECLEQCGRVLELLKQYQNFKSILTTLIQ-KEESVISLQASYMGKEN---LKKRIAEIE 1578
+ E + G LE L I Q K S++ S +G N K + EI+
Sbjct: 2817 LVEEINCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871
Query: 1579 IVKEEFNEHLEVVDKI-NQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINE---KT 1634
+ N E + + ++ ++LQ LN+M+ KEAN ++ +WL+ E K+
Sbjct: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVH-----KEANSVL-QWLESKEEVLKS 2925
Query: 1635 EDYYENLGRALALWDKLFNLKNVIDEWTEKA--LQKMEL----------HQLTEEDRERL 1682
D + + + + + K + E + + +QK++ + E+ +++
Sbjct: 2926 MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI 2985
Query: 1683 KEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA 1742
+EEL ++ +E + VA + L +S+ Q ES + + +
Sbjct: 2986 QEELNSRWERATEVT--VARQRQLEESASHLACFQAAESQLRPWLMEKE----------L 3033
Query: 1743 LSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLEN 1802
+ G L D + Q + +LK +L E Q IL + L +
Sbjct: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQH--EQLNEAAQGILTGPGDVSLSTS 3091
Query: 1803 QIGCLTPELSELKKQYESVSDLFNTKKS------VLQDHFSKLLNDQCKNFNDWFSNIKV 1856
Q+ EL + +++ ++D N++ S V + +LL D + + V
Sbjct: 3092 QV---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV 3148
Query: 1857 NLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVK-ELIS 1915
+ K+ +E+ + SD LE + ++K+ ++ + + + ++K EL
Sbjct: 3149 QSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK 3205
Query: 1916 WLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEK 1975
L L+ +E + R L+ +L + Q LR WL +++ + K
Sbjct: 3206 RLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAK 3265
Query: 1976 TELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEE- 2034
E Q+ ++ E+F+ ++ E E E +++ ++ +TL QL E++
Sbjct: 3266 LERL-QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEK-RTLQNQLVELKNH 3323
Query: 2035 -EDKLLPTED------------QSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQ 2081
E+ T D Q + D++ WI++ K + L + + LE +
Sbjct: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
Query: 2082 KIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLL 2141
+ K ++ + + +E + A+ L+ + D D + + E+L
Sbjct: 3384 RSKAMLNEVEKRRSLLEILNSAADI----LINSSEADEDGIRDEKAGINQNMDAVTEEL- 3438
Query: 2142 LEGEKYLQSKE-DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIY---------KKFLKK 2191
Q+K L M L++ QE+ ++ ++ K QL+I+ K L+K
Sbjct: 3439 -------QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEK 3491
Query: 2192 AQDLTSLLKELKSQGNYLLECTKN-----------------PSFSEEPWLEIKHLHESLL 2234
+ +L+ L+ Q +YL T+ +++ +LE+K S
Sbjct: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
Query: 2235 QQLQDSVQNLDG-HVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQ 2293
+++ ++ + H R + + + DL+ LD D +++ +++ ++
Sbjct: 3552 VMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAI-------GRDTDSLQSQIEDVR 3603
Query: 2294 ELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEM 2353
N++ + ++ A + + + ++ +K ++++L + L R + ++++
Sbjct: 3604 LFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQL 3663
Query: 2354 ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEM 2413
E L + R + T E +A V + E + + D+++ + V+
Sbjct: 3664 ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE--IINQQLADFKMFQKEQVDP 3721
Query: 2414 AMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIK 2473
K +N +Q+ + D +EEI + L KK A +
Sbjct: 3722 LQMKLQQVNGLGQ----------GLIQSAGKDCDVQGLEHDMEEINARWNTLN-KKVAQR 3770
Query: 2474 PLEQTECLNKTETGALVLHNIGYSAQHLDNLL------QALITLKKNKESQYCVLR-DFQ 2526
+ E L LH G L+ LL + LI +K ++Y V++ Q
Sbjct: 3771 IAQLQEAL---------LH-CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
Query: 2527 EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSN 2586
E + ++ LL D+++ V L + +A EK L +L+ +W L +
Sbjct: 3821 E-----QKLLQRLLDDRKAT-VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3874
Query: 2587 HVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQ 2646
K+L + + + K++ + +F ++ K + Q
Sbjct: 3875 KAAARQKQLEDILV-------------LAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3921
Query: 2647 QHLQ---LRLKSPEERAGNQSMIALTTDL-QATKHGFSVLKGQAELQMKRIWGEKEKKNL 2702
+Q +R K+ EE N + TD+ QA K G S + + E+ L
Sbjct: 3922 AKIQQQIIRHKALEEDIENHA-----TDVHQAVKIGQS---------LSSLTSPAEQGVL 3967
Query: 2703 EDGINNLKKQWETLEPLHLEAENQIKKCDIRNKM-----KETILWAKNLLGELNPS-IPL 2756
+ I++L+ ++ ++ + + ++ E + W + +L+ +
Sbjct: 3968 SEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKD 4027
Query: 2757 LPDDILSQIRKCKVT-HDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQY 2815
D+L + + ++ I+ R+++V+ + + + T E + L+ ++ +Y
Sbjct: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRY 4087
Query: 2816 QMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHV 2875
+ + S++ + LE + + F + + ++E E + T+ ++
Sbjct: 4088 ADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE----ELATSGGQSPTGEQIP 4143
Query: 2876 TLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLE-------DQLKNLKIRTNRIQ 2928
+ QKEL++ + E + + +N R LE + L L N
Sbjct: 4144 QFQQRQKELKK-------EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQY 4196
Query: 2929 RFIQNTC----NEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
+ + +T +E++ I+ +Q+ + A +R + L ++ E
Sbjct: 4197 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP-----IRLEQDQT 4251
Query: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKE-LEEK----IKQLD 3039
+L K + +++ K D + FS ++ E++K L+EK I+Q +
Sbjct: 4252 TAQLQVQKAFSIDIIRHKDSMDEL-----FSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 4306
Query: 3040 TFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCD 3099
+ + A L + + + + + E + E+R L AQ+ S I+ +
Sbjct: 4307 AISLLNSERYARLERAQVL---VNQFWETYEELSPWIEETRALIAQLPSPAIDH-----E 4358
Query: 3100 EIIKKLNENKTFDDSFKEKE-----ILQI-----KLNAEENDKL---YKVLQNMVLELSP 3146
++ ++ E + +S E + +L+I +LN EE + + Y+ +NM ++
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
Query: 3147 K------ELDEKNCQ--------DKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC 3192
+ LDE Q DK+E L L + S+L+ P LI E+ I+ C
Sbjct: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE----C 4474
Query: 3193 EAFQEQVWAEMCSIK-AVTAIEKQREE--NSSEASDVETKLREFEDLQMQLNTSIDLRTN 3249
+ + E+ ++ + A++++ EE S+ +D + +E +D +L+ + +
Sbjct: 4475 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD---KLDQMVFFWED 4531
Query: 3250 VLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP------LRKQEEL 3303
+ A E ++ + + A + + A++ + D + LE P +++Q E
Sbjct: 4532 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIK-DTQDIVHDLESPGIDPSIIKQQVEA 4590
Query: 3304 ESTVAHIQD-LTEKL--------------GMISSPEAKLQLQYTLQELVSKNSAMKEAFK 3348
T+ D L E+L G PE + + + N KE +
Sbjct: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE 4650
Query: 3349 AQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVS 3408
E + ++ + M + + + K+ T M + ++L + K
Sbjct: 4651 KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-----MPPVGTDLNTVKDQLNEMKEFKV 4705
Query: 3409 NLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELK 3468
+ + E+ KL L+ + T+ +++ L E WE E++
Sbjct: 4706 EVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE---------PLTELKHLWENLGEKIA 4756
Query: 3469 QEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVE----KQ 3524
++E + L Q L E+ TEEL + + + +E K
Sbjct: 4757 HR----QHKLEGALLALGQFQHALEELMSW--LTHTEELLDAQRPISGDPKVIEVELAKH 4810
Query: 3525 QLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKL-------LQKVQKNKEL 3577
+L +L +++ V ++ + A + +S++ R + LQK ++ ++
Sbjct: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
Query: 3578 VQTEIQERHSFTKEI----IALKNFFQQTTTSFQNMAFQDHP-EKSEQFEELQSILKKGK 3632
+Q+ +Q+ F EI + L Q + S + E+ + EL S LK +
Sbjct: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
Query: 3633 LTFENIMEKLRI------------KYSEMYTIVPAE---IESQVEECRKALEDIDEKISN 3677
T+ +++K R+ K + ++ + + S++EE + LE
Sbjct: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE-------- 4982
Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKS------KNIEKAQEIQKKMWDELDLWH 3731
E L + + + ++E N L E+ L S + E K +E++
Sbjct: 4983 EALNLATEF--QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
Query: 3732 SKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ-QYQQVSQRAECRTSQLNKATVKMEEY 3790
++ ELD + Q + NL++ Q ++++V QR+ R L+ A + +++
Sbjct: 5041 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100
Query: 3791 SDLLKSTEAWIENT-SHL-----LANPADYDSLRTLSH 3822
+ K W+E+ SHL ++N D L+ H
Sbjct: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH 5138
Score = 97.4 bits (241), Expect = 4e-19
Identities = 130/690 (18%), Positives = 276/690 (40%), Gaps = 60/690 (8%)
Query: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
G++ + L + + C E R + L++ L + + +EI+ +L + ++ L
Sbjct: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQL 4899
Query: 4657 QQSLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
S G ++ EQL +L+ E +L D+G + L K E
Sbjct: 4900 SAS-KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQ 4958
Query: 4715 ---VLDSMWGMLRARYTELSSPF------VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
+L+ W ++ ++ E S TE Q LQ + + + ++ L ++
Sbjct: 4959 SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS--LQEFINWLTLAEQSL---NIAS 5013
Query: 4766 TKSKV--ALQAQIENHKVFFQKLVADM--------------LLIQAYSAKILPSLLQNRE 4809
S + + +QIE HKVF ++ A L Q ++ +LL + +
Sbjct: 5014 PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQ 5073
Query: 4810 TFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE 4869
+ W + V ++S + G L ++ ++F E + L LE S L S +
Sbjct: 5074 SRWEKVV-------QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE----LEGQIAKLEEQW 4925
+++ ++S +++ ++ +GGK T+ G+ L PE L+ + ++ ++W
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186
Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
++ K H+L+ L + L WL + L + V DLD +
Sbjct: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL----AEDQPVHGDLDLVM 5242
Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLP 5045
+ ++ F KE+ +++ + G +L+ DT ++ L + +W +
Sbjct: 5243 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 5302
Query: 5046 DIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFR 5105
Q +L Q + R + ++ W++ E ++ P ++ L+ HKEF
Sbjct: 5303 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL--PDDTEALQSLIDTHKEFM 5360
Query: 5106 MEMDYKQWIVD-FVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQH 5164
+++ K+ V+ V + L+ C + T + + ++ V + Q
Sbjct: 5361 KKVEEKRVDVNSAVAMGEVILAVCHPDC----ITTIKHWITIIRARFEEVLTWAKQHQQR 5416
Query: 5165 LEQLLESITESENKIQILNNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAI 5221
LE L + + ++ L W++ E L + P+++ V+ L+ + Q ++
Sbjct: 5417 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
Query: 5222 KSKALDELKQSY--LTLESGAVPLLEDTAS 5249
K +D + ++Y +E P +E + S
Sbjct: 5477 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRS 5506
Score = 83.2 bits (204), Expect = 8e-15
Identities = 385/2184 (17%), Positives = 812/2184 (37%), Gaps = 318/2184 (14%)
Query: 286 KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNE--EK 343
KD ++ Q V+D + W+ K K+ +L + + +SLL NE ++
Sbjct: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKR 3395
Query: 344 KSFLDVLSIKRDL----DELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL 399
+S L++L+ D+ E D+D ++ +A G++ ++A +L A L + L
Sbjct: 3396 RSLLEILNSAADILINSSEADEDGIRDEKA--GINQNMDAVTEELQ-AKTGSLEEMTQRL 3452
Query: 400 QEVEELMDEDLSASQDHSQAVTLIQ------------EKMTLFKSLMDRFEHHSNILLTF 447
+E +E + + + EK+ + ++ E + L F
Sbjct: 3453 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3512
Query: 448 ---------ENKDEN---HLPLVPPNKLEEMKRRINN---ILEKKFILLLEFHYYKCLVL 492
+ D + H V + E+K+R+N+ ++E K + +FH +
Sbjct: 3513 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3572
Query: 493 GLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLAR-LDTSFQKCGEIYKN--- 548
+ ++ +LD +S++ +ED F+ + L ++ S +C + +
Sbjct: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3632
Query: 549 -----LAGECQNINKQYMMVKS-----------------DVCMYRKNIYNVKSTLQKVLA 586
L E + +NKQ + D K + + + ++ A
Sbjct: 3633 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA 3692
Query: 587 C-WA--TYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVV 643
W T VE + A F+ +KE++ + + L + AG DV
Sbjct: 3693 LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQ 3747
Query: 644 GSSISKELRRLNKRWRKLVSKT-----QLEMNLPLMIKKQD--QPTFD---NSGNILSKE 693
G + ++ +N RW L K QL+ L K QD +P ++ +++ +
Sbjct: 3748 G--LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3805
Query: 694 EKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTG----QLKVAKDVEKLIGQVEIW 749
+ + E+ + + Q + K + + G Q D EK+ GQ+E
Sbjct: 3806 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3865
Query: 750 EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESF----- 804
E+ +L + + ++ L+ ++ F E D L + + +++ E
Sbjct: 3866 ESRWTELLSKA---AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3922
Query: 805 ----QHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQ---KEL 857
Q + L+ I+ V VK+ +L +LT + + K++ Q E+
Sbjct: 3923 KIQQQIIRHKALEEDIENHATDVH-QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3981
Query: 858 ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
+ R LL Q S L + + ++ +L VE+ ++V +++
Sbjct: 3982 QDRCCRKAALLDQALSNARLFGEDEVEVL--------NWLAEVEDKLSSVF------VKD 4027
Query: 918 KSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIK 977
+DV + + H L+ + K ++++ N L KQ E+ L+ + + G+
Sbjct: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQA--IKNGQALLKQTTGEEVLLIQEKLDGIKT 4085
Query: 978 EH-EACFSEEGCLYQLNHHMEV--------------LRELCEELPSQKSQQEVKRLLKDY 1022
+ + + L L ++ LRE+ EEL + Q + +
Sbjct: 4086 RYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 4145
Query: 1023 EQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGG------DPHSEAPFAKS--- 1073
+Q+ + L K E H + T S+ + R G D + +
Sbjct: 4146 QQRQKELKKEVME-HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 4204
Query: 1074 DNQPSTEKAMEPTMKFSLAS---------------VLRPLQEESIMEKDYSASINSLLER 1118
+ A++ + ++ A+ L P++ +E+D + + + +
Sbjct: 4205 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----LEQDQTTAQLQVQKA 4260
Query: 1119 YDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISL 1178
+ DI+ H K + FS + +C + + T V++ +T++ +++E ISL
Sbjct: 4261 FSI--DIIRH-----KDSMDELFSHRSEIFGTCGEEQKT---VLQEKTESLIQQYEAISL 4310
Query: 1179 KLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSD 1238
+ ER ER Q+ +N E+ E L +E+ L+
Sbjct: 4311 -------------LNSERYARLERA---QVLVNQFWETYE---ELSPWIEETRALIAQLP 4351
Query: 1239 LPLHKMAIQGFHLIDADRIYQH---LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLH 1295
P ID +++ Q +R +++SIA+ ++L + G LKEL+P +
Sbjct: 4352 SPA----------IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP-QLKELNPEEGE 4400
Query: 1296 AMQNIILKYKTQFEGMNHRVQRS---------------------EDTLKALEDFLASLRT 1334
++ K + + + V++ E L+ LE+ + LR
Sbjct: 4401 MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRM 4460
Query: 1335 AKLSAEPVTDLSA--SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
L V + SD + A T+ ++ + +K + + L + D E
Sbjct: 4461 PPLIPAEVDKIRECISDNKSA---TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4517
Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEE--FTEENKLLEACIFKNNELLKNIQDVQSQI 1450
D LD + + E F + +L E + LL I+D Q +
Sbjct: 4518 IQDK------LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
Query: 1451 SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT-VNQQC 1509
+ +K + ++ + + D EE ++ + L EK V +
Sbjct: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631
Query: 1510 QNTVVLWENTKALVTECLEQCGRVLELLKQYQN-FKSILTTLIQKEESVISLQASYMGKE 1568
WEN E LE+ ++ QYQ+ +++ L + ++
Sbjct: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4691
Query: 1569 NLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPP---FEKEANIIVD 1625
+K ++ E++ K E + ++K+N Q L K +E + +
Sbjct: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNH-----QGELMLKKATDETDRDIIREPLTELKH 4746
Query: 1626 RWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEE 1685
W ++ EK L AL + + + W + ++ + D + ++ E
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
Query: 1686 LQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME--SSILNKMEHVQKCLTGESNCHAL 1743
L H ++ A ++ + ++ LE + SS+ +++E + +C ES
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW--ESVLQKT 4864
Query: 1744 SGSTAELREDLDQAK----------TQIGMTESLLKALSPSDSL------------EIFT 1781
+L+ L QA+ ++ ES L A P+ L E+++
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4924
Query: 1782 KL---EEIQQQILQQKHSMILLENQIGC---LTPELSELKKQYESVSDLFNTKKSVLQD- 1834
+L EE Q+L + M+L + G ++ L++++ VS +KS L++
Sbjct: 4925 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
Query: 1835 -HFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLT-LEGRNSKIK 1892
+ + + + F +W + + +L S +V ++++ F + +I
Sbjct: 4985 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
Query: 1893 QVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDH 1952
++D +K K V + + LV + EK+ R + L+D+ ++ + +
Sbjct: 5045 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 5104
Query: 1953 RNLRKWLTNQEEKWKGMEEPGE----------KTELFCQALARKREQFESVAQLNNSLKE 2002
+ L WL + E E K + F + L K+ +++ + +LKE
Sbjct: 5105 KKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE 5164
Query: 2003 YGFTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
E+ ++ + D++ T+ + E + + + F D ++ W+ ++
Sbjct: 5165 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 5224
Query: 2061 KESL-----------MVLNSSEGKMPLEERIQKIKEII-LLKPEGDARIETIMKQAESSE 2108
+ L +V+N + ++ + K + +LK G IE +
Sbjct: 5225 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-----SRDD 5279
Query: 2109 APLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
V+ L ++S +WD L+ + S E+ L + E + + L L E ++
Sbjct: 5280 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 5339
Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE-CTKNPSFSEEPWLE-I 2226
AL + ++ + +K+F+KK ++ + + G +L C + + + W+ I
Sbjct: 5340 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 5399
Query: 2227 KHLHESLLQQLQDSVQNLDGHVRE 2250
+ E +L + Q L+ + E
Sbjct: 5400 RARFEEVLTWAKQHQQRLETALSE 5423
Score = 59.7 bits (143), Expect = 1e-07
Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 32/258 (12%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4804
Query: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ L+ +L Q Q FH ++ LL L +++ + T L E RE +
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG------GLPETAREQLDT 4918
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGH---------------GEDCIEAEEKVHVIEKKLK 6777
EL Q+ +E N LL KG + E+K HV+ K++
Sbjct: 4919 HMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
Query: 6778 QLREQVSQDLMALQGTQN 6795
+ + ++ + L QN
Sbjct: 4976 ERKSKLEEALNLATEFQN 4993
Score = 55.1 bits (131), Expect = 2e-06
Identities = 73/336 (21%), Positives = 140/336 (41%), Gaps = 21/336 (6%)
Query: 6547 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 6602
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 3858 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
Query: 6603 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 3918 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3973
Query: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720
L + Q L Q+L + F + +L WLA +++ V D K D
Sbjct: 3974 LQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 4031
Query: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
L + + L +E+V R+ VD + +LL + GE+ + +EK+ I+ + +
Sbjct: 4032 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 4091
Query: 6781 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRV 6840
S+ L L+ + A+ S E +G R + T+ G+ T ++
Sbjct: 4092 VTSSKALRTLEQARQLATKFQSTYEELTG---------WLREVEEELATSGGQSPTGEQI 4142
Query: 6841 PGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6876
P + Q+ V+ L L + + L L+P
Sbjct: 4143 PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
Score = 51.2 bits (121), Expect = 3e-05
Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 8/234 (3%)
Query: 6574 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 6631
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Query: 6632 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6691
L + S+ F + T LQ + L +EA L ++ + F +
Sbjct: 4275 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE 4331
Query: 6692 LSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISN 6751
+ L W+ + R A + P D L + + E+ QL + + E +P +D L +I
Sbjct: 4332 TYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389
Query: 6752 SLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDE 6805
L + + E+ EEK E Q++E+V Q +AL + ++ + F +
Sbjct: 4390 QLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
Score = 50.8 bits (120), Expect = 5e-05
Identities = 45/199 (22%), Positives = 85/199 (42%), Gaps = 11/199 (5%)
Query: 6565 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 6624
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 2365
Query: 6625 AFDTYKALVVSVNVSSKEFLQTESP-----ESTEL----QSRLRQLSLLWEAAQGAVDSW 6675
++K + V +S ++ L E+ E +E+ + +L+ + + A
Sbjct: 2366 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 2425
Query: 6676 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKE 6735
L L Q F + +L W+ + + +K +DP L E QL++E
Sbjct: 2426 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 2485
Query: 6736 LVERQPQVDMLQEISNSLL 6754
L E Q V+ LQ+++ ++
Sbjct: 2486 LAEHQVPVEKLQKVARDIM 2504
Score = 50.8 bits (120), Expect = 5e-05
Identities = 48/216 (22%), Positives = 94/216 (43%), Gaps = 18/216 (8%)
Query: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
D+W+ + + + + K+++ L Q + A+ WL K E +L + D+
Sbjct: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDL--- 5240
Query: 6613 ELRVKRLQEILKAFDTY----KALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 6668
V L + K F V + S +E ++ ++T ++ +L++LS W+
Sbjct: 5241 ---VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 5297
Query: 6669 QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRR 6727
S + L Q+L Q + F LL WL+ A+ R + + D ++L++ +
Sbjct: 5298 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 5357
Query: 6728 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6763
E M K++ E++ V+ + +L H DCI
Sbjct: 5358 EFM---KKVEEKRVDVNSAVAMGEVILAVCH-PDCI 5389
Score = 44.7 bits (104), Expect = 0.003
Identities = 43/238 (18%), Positives = 100/238 (42%), Gaps = 14/238 (5%)
Query: 6559 EMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR 6618
E + A ++ + QQ + TWL +++ K + ++ ++ +++
Sbjct: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ--QAKNCPISAKLERLQSQLQE 3275
Query: 6619 LQEILKAFDTYKALVVSVNVSSKEFLQTESP--ESTELQSRLRQLSLLWEAAQGAVDSWR 6676
+E K+ + + + + L + P E LQ++L +L WE +
Sbjct: 3276 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQ 3335
Query: 6677 GGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT-DPKADPRALLECRRELMQLEKE 6735
L+ + + Q + ++L+ W+ K + + VT DP +LL + L ++EK
Sbjct: 3336 SRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK- 3394
Query: 6736 LVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGT 6793
R+ +++L ++ L+ ++ +EK + Q + V+++L A G+
Sbjct: 3395 ---RRSLLEILNSAADILINSSEADEDGIRDEKAGI-----NQNMDAVTEELQAKTGS 3444
Score = 41.6 bits (96), Expect = 0.028
Identities = 63/323 (19%), Positives = 125/323 (38%), Gaps = 52/323 (16%)
Query: 6560 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 6619
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3680
Query: 6620 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLL-------- 6664
+ A + +AL V +N +F + + LQ +L+Q++ L
Sbjct: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740
Query: 6665 -------------------WEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
W V L+++L+ C F + LL WLA +
Sbjct: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE- 3799
Query: 6706 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 6765
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 3800 -ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858
Query: 6766 EEKVHVIEKKLKQL------REQVSQDLMAL----QGTQNPASPLPSFDEVDSGDQPPAT 6815
++ +E + +L R++ +D++ L T P S S E + P
Sbjct: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
Query: 6816 SVPAPRAKFRAVRTTEGEEETES 6838
+ A + + + +R EE+ E+
Sbjct: 3919 TQTA-KIQQQIIRHKALEEDIEN 3940
Score = 38.1 bits (87), Expect = 0.31
Identities = 50/230 (21%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 219 IIHALRPDLIDMKSVKHRSNK-DNLREAFRIAEQELKIPRLLEPEDVDVVDPDEK-SIMT 276
I+H L ID +K + + ++E +EL+ R+L + + EK +
Sbjct: 4570 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629
Query: 277 YVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEN-------------- 322
+ + ++ T +E K++DAM ++ LQ + +N
Sbjct: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689
Query: 323 -DTYFKKYNSLLSF-----MESFNEEKKSFLDVLSIKRDLDELDKDHL-----QLREAWD 371
+T + N + F + EK + L +K+ DE D+D + +L+ W+
Sbjct: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749
Query: 372 GLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQD 415
L +I + KL AL L + +WL EEL+D S D
Sbjct: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4799
Score = 38.1 bits (87), Expect = 0.31
Identities = 45/255 (17%), Positives = 97/255 (38%), Gaps = 13/255 (5%)
Query: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 6614
WE + K++ +Q Q + A+ WL T +++ M +D+ ++
Sbjct: 4638 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV--IKLCTMPPVGTDLNTVKD 4695
Query: 6615 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAV 6672
++ ++E + + +N + L+ + E+ ++ L +L LWE +
Sbjct: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4755
Query: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
+ L +L+ F + L+ WL + DP+ + + L
Sbjct: 4756 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI--SGDPKVIEVELAKHHVL 4813
Query: 6733 EKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI----EKKLKQLREQVSQDLM 6788
+ +++ Q V+ + + N LL G+D ++ + E L++ E+ Q
Sbjct: 4814 KNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
Query: 6789 ALQGTQNPASPLPSF 6803
LQ Q S + F
Sbjct: 4874 TLQQAQGFHSEIEDF 4888
Score = 33.5 bits (75), Expect = 7.5
Identities = 40/204 (19%), Positives = 86/204 (42%), Gaps = 23/204 (11%)
Query: 6607 SDIQEIELRVKRLQEILKAFDTY---------KALVVSVNVSSKEFLQTESPESTELQSR 6657
+++Q++ + K L+ LK T + ++ + L+ ++ LQ
Sbjct: 1835 AELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKS 1894
Query: 6658 LRQLSLLWEAA----QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT 6713
L +S W + Q AV+ + + L Q Q+L W+ + KN + +
Sbjct: 1895 LSSVSDTWNSRLLHFQNAVEIEK---TKVLNQHTQLEGRLQDLRAWVGN-KNLILNSKGS 1950
Query: 6714 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK----- 6768
+ + D +L C ++ L++ + ER+ Q+D L I H +D + +
Sbjct: 1951 NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNRQMLRL 2009
Query: 6769 VHVIEKKLKQLREQVSQDLMALQG 6792
++ +++ + + EQ + + ALQG
Sbjct: 2010 LNELQRSFQDILEQTAAQVDALQG 2033
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 203 bits (517), Expect = 4e-51
Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 39 ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 96
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 146
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S M+A++ LLLW+Q Y+ + +F
Sbjct: 147 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 184
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PEDVDV
Sbjct: 185 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 244
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
PDEKSI+TYV+ P + + + + W ++ L L + F+
Sbjct: 245 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 303
Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
+ F SF E + + L K +L + D + + + L+ + A ++K
Sbjct: 304 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 356
Query: 387 ALPPPLH 393
+PP H
Sbjct: 357 -VPPGYH 362
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1109 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1168
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1229 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1283
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1327
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1382
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1439
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1495
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1496 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1670 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1703
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1704 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1742
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1849
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1967
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2086
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2087 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2145 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2198 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2234
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2235 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2278
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2339 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2510
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2511 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2552
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2721
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 603 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 662
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 663 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 719
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 720 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 780 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 836
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 837 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 896
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 897 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 941
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 942 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 990
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1099
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1100 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1146
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1196
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1197 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1234
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1294
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1342
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1403 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1452 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1493
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1494 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1543 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1638
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1639 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1743
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1859
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1911
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2030
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2209 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2386 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2445 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2558
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2676
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2677 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2734
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2735 ASGFLLDPVRNRRLTVNEAVK 2755
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 935 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 993
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 994 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1048
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1108
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1109 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1228 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1279
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1398
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1514
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1515 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1677
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1678 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1732
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1733 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1789
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1790 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1845 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2077 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2131
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2132 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2177
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2235 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2289
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2341
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2342 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2390
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2568 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2680
Query: 3736 EL 3737
EL
Sbjct: 2681 EL 2682
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 269 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 328
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 329 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 387
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 388 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 447
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 448 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 507
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 508 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 557
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 558 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 603
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 604 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 659
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 660 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 711
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 712 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 764
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 765 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 989
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 990 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1049
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1050 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1339 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1392 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1429
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1605
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1606 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1659
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1711
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1712 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1827
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1828 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 1991
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2046
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2225
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2284
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQ 2304
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 1015 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1074
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1180
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1238
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1239 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1350 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1518
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1519 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1571
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1572 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1684 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1789 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 1905 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 1964 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2016
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 2017 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2069
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2070 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2127
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2128 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2186 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2235
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2293
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2294 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1253 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1312
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1426
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1487 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1526
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1527 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1577
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1578 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1633
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1745
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1801
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1844
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1897
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 1958 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2071
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2127
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2185
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2186 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2302 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2353
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2354 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2469 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2586 LLAEENQRLREQLQLLE 2602
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1342
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1343 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1376
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1377 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1433 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1541
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1542 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1592
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1593 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1650 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1704
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1705 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1743
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1744 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1792
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1793 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1827
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1880
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1926
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 1927 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1976
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2037 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2060
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2061 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2091
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2149
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2150 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2188
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2189 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2242
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2243 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2353
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2414 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2517
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2518 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2628 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2731
Query: 6198 KQ 6199
Q
Sbjct: 2732 AQ 2733
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1279 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1445
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1503
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1504 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1556
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1557 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1601
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1602 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1656
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1657 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1706 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1744
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1856
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1914
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 1915 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 1974 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2091
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2092 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2207 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2264 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2319
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2320 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2374
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2375 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2423
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2481
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2482 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2535 QRQQQQMEQE 2544
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1973
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 1974 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2028
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2209 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2373
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2426
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2482
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2483 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2510
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 203 bits (517), Expect = 4e-51
Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 43 ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 100
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 101 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 150
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S M+A++ LLLW+Q Y+ + +F
Sbjct: 151 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 188
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PEDVDV
Sbjct: 189 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 248
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
PDEKSI+TYV+ P + + + + W ++ L L + F+
Sbjct: 249 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 307
Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
+ F SF E + + L K +L + D + + + L+ + A ++K
Sbjct: 308 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 360
Query: 387 ALPPPLH 393
+PP H
Sbjct: 361 -VPPGYH 366
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1113 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1172
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1173 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1232
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1233 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1287
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1331
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1386
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1443
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1444 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1499
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1500 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1613
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1674 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1707
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1708 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1746
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1807 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1853
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1854 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 1914 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1971
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2031
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 2032 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2090
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2091 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2149 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2202 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2238
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2239 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2282
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2342
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2343 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2514
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2515 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2556
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2616
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2617 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2676
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2677 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2725
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 607 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 666
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 667 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 723
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 724 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 783
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 784 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 840
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 841 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 900
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 901 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 945
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 946 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 994
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 995 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1050
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1051 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1103
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1104 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1150
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1151 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1200
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1201 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1238
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1298
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1346
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1407 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1456 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1497
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1498 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1546
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1547 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1642
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1643 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1747
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1863
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1915
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 1916 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1975
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 1976 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2034
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 2035 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2213 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2390 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2449 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2562
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2622
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2623 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2680
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2681 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2738
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2739 ASGFLLDPVRNRRLTVNEAVK 2759
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 939 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 997
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 998 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1052
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1053 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1112
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1113 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1171
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1172 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1231
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1232 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1283
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1284 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1343
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1402
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1518
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1519 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1569
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1681
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1682 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1736
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1737 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1793
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1794 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1849 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1960
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2081 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2135
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2136 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2181
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2239 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2293
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2294 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2345
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2346 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2394
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2572 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2630 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2684
Query: 3736 EL 3737
EL
Sbjct: 2685 EL 2686
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 273 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 332
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 333 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 391
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 392 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 451
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 452 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 511
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 512 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 561
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 562 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 607
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 608 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 663
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 664 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 715
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 716 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 768
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 769 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 822 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 882 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 942 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 993
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 994 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1053
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1054 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1102
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1222
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1223 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1282
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1343 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1395
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1396 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1433
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1609
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1610 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1663
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1715
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1716 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1831
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1832 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1948
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 1949 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 1995
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2050
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2170
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2171 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2229
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2288
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQ 2308
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 959 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1018
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 1019 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1078
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1079 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1138
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1139 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1184
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1242
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1243 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1354 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1522
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1523 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1575
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1576 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1688 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1732
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1733 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1793 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 1909 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 1968 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2020
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 2021 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2073
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2074 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2131
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2132 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2190 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2239
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2297
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2298 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1256
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1257 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1316
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1317 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1376
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1430
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1490
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1491 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1530
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1531 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1581
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1582 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1637
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1749
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1805
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1848
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1901
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 1962 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2075
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2131
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2189
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2190 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2306 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2357
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2358 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2473 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2530 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2589
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2590 LLAEENQRLREQLQLLE 2606
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1346
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1347 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1380
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1381 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1436
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1437 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1490 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1545
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1546 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1596
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1597 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1654 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1708
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1709 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1747
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1748 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1796
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1797 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1831
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1832 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1884
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 1885 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1930
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 1931 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1980
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2041 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2064
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2065 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2095
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2153
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2154 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2192
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2193 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2246
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2247 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2357
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2418 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2521
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2522 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2572 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2632 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2682 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2735
Query: 6198 KQ 6199
Q
Sbjct: 2736 AQ 2737
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1223 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1282
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1283 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1330
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1331 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1390
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1449
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1507
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1508 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1560
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1561 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1605
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1606 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1660
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1661 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1709
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1710 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1748
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1749 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1860
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1918
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 1919 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 1978 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2095
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2096 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2211 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2267
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2268 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2323
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2324 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2378
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2379 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2427
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2485
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2486 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2538
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2539 QRQQQQMEQE 2548
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1925
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 1926 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1977
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 1978 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2032
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2213 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2271
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2331
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2332 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2377
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2430
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2486
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2487 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2514
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 203 bits (517), Expect = 4e-51
Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 7 ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 64
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 65 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 114
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S M+A++ LLLW+Q Y+ + +F
Sbjct: 115 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 152
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PEDVDV
Sbjct: 153 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 212
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
PDEKSI+TYV+ P + + + + W ++ L L + F+
Sbjct: 213 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 271
Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
+ F SF E + + L K +L + D + + + L+ + A ++K
Sbjct: 272 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 324
Query: 387 ALPPPLH 393
+PP H
Sbjct: 325 -VPPGYH 330
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1077 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1136
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1137 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1196
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1197 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1251
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1295
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1350
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1351 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1407
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1408 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1463
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1464 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1577
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1638 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1671
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1672 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1710
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1771 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1817
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1818 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 1878 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1935
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 1995
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 1996 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2054
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2055 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2113 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2166 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2202
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2203 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2246
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2306
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2307 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2478
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2479 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2520
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2580
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2581 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2640
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2641 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2689
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 571 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 630
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 631 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 687
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 688 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 747
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 748 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 804
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 805 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 864
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 865 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 909
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 910 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 958
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 959 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1014
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1015 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1067
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1068 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1114
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1115 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1164
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1165 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1202
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1262
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1263 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1310
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1371 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1420 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1461
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1462 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1510
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1511 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1606
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1607 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1711
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1827
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1879
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 1880 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1939
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 1940 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 1998
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 1999 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2177 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2354 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2413 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2526
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2586
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2587 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2644
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2645 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2702
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2703 ASGFLLDPVRNRRLTVNEAVK 2723
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 903 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 961
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 962 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1016
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1017 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1076
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1077 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1135
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1136 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1195
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1196 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1247
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1248 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1307
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1366
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1482
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1483 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1533
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1534 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1645
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1646 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1700
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1701 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1757
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1758 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1813 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1924
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2045 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2099
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2100 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2145
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2203 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2257
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2258 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2309
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2310 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2358
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2536 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2594 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2648
Query: 3736 EL 3737
EL
Sbjct: 2649 EL 2650
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 237 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 296
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 297 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 355
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 356 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 415
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 416 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 475
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 476 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 525
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 526 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 571
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 572 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 627
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 628 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 679
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 680 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 732
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 733 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 786 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 846 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 906 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 957
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 958 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1017
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1018 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1066
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1186
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1187 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1246
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1307 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1359
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1360 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1397
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1573
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1574 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1627
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1679
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1680 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1795
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1796 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1912
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 1913 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 1959
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2014
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2134
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2135 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2193
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2252
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQ 2272
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 923 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 982
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 983 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1042
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1043 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1102
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1103 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1148
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1206
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1207 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1257
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1318 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1486
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1487 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1539
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1540 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1652 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1696
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1697 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1757 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 1873 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 1932 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 1984
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 1985 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2037
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2038 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2095
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2096 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2154 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2203
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2261
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2262 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1160
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1161 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1220
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1221 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1280
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1281 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1340
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1394
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1395 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1454
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1455 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1494
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1495 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1545
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1546 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1601
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1713
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1769
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1812
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1865
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 1926 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2039
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2095
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2153
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2154 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2270 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2321
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2322 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2436
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2437 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2494 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2553
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2554 LLAEENQRLREQLQLLE 2570
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1310
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1311 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1344
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1345 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1400
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1401 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1454 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1509
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1510 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1560
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1561 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1618 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1672
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1673 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1711
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1712 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1760
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1761 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1795
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1796 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1848
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 1849 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1894
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 1895 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1944
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2005 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2028
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2029 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2059
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2117
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2118 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2156
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2157 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2210
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2211 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2321
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2382 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2485
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2486 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2536 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2596 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2646 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2699
Query: 6198 KQ 6199
Q
Sbjct: 2700 AQ 2701
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1187 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1246
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1247 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1294
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1295 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1354
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1413
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1414 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1471
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1472 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1524
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1525 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1569
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1570 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1624
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1625 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1673
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1674 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1712
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1713 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1824
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1882
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 1883 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 1942 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2059
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2060 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2175 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2231
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2232 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2287
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2288 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2342
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2343 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2391
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2449
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2450 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2502
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2503 QRQQQQMEQE 2512
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1889
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 1890 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1941
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 1942 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 1996
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2177 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2235
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2295
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2296 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2341
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2394
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2450
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2451 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2478
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 203 bits (517), Expect = 4e-51
Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK FT W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 176 ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 233
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 283
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S M+A++ LLLW+Q Y+ + +F
Sbjct: 284 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 321
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PEDVDV
Sbjct: 322 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 381
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
PDEKSI+TYV+ P + + + + W ++ L L + F+
Sbjct: 382 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 440
Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
+ F SF E + + L K +L + D + + + L+ + A ++K
Sbjct: 441 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 493
Query: 387 ALPPPLH 393
+PP H
Sbjct: 494 -VPPGYH 499
Score = 103 bits (257), Expect = 6e-21
Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)
Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
+ Q+ + T+P ++ K SL +L D +E R QE+ L
Sbjct: 1246 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1305
Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
R+ V + + L E +A++ + LEQ GR L ++ + + L +
Sbjct: 1306 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1365
Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
++E + ++ + + +++++ + + + EE H E V++ + K Y+N +K +E
Sbjct: 1366 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1420
Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
+A + K + E+ VI E+ + EL
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1464
Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
LT E R++EE ++ EQ+ +E R+AE++ L+ + Q+ E+
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1519
Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
K + ++ + E D Q K I + L+ L S EI K +
Sbjct: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1576
Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
I+++I + + E Q G EL L+ + E +K Q+
Sbjct: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1632
Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
++ L Q ++ + +V L +S K E +K LE + ++ +
Sbjct: 1633 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686
Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
L+ + + L + E EL+ + + +LE SLQ+ + +L+++
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746
Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
+ E + E E+ +L R R Q E VAQ + + ++EE
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806
Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
EA + +RQ +LA + +++ E
Sbjct: 1807 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1840
Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
++R+ +E+I L+ E +Q E + L+++ L + +
Sbjct: 1841 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1879
Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
+ Q++ LE E E L+ + + ++E+ + Q +A+ +++ ++
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
A L +L +E K Q E E + L + + + R
Sbjct: 1940 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1986
Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
++ + + + + E +F + +++ A + K + L D L++
Sbjct: 1987 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046
Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
L + + V ++I +K + + +LE L + E L S K +
Sbjct: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 2104
Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
E + L E++ + +E Q+S A E K+EE + +
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2164
Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
+ E A QL+ A + E++ +Q + EL L+ EQ +++L + EA
Sbjct: 2165 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2223
Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
+ A + E+ + E A A+ L + + ++ LR E
Sbjct: 2224 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
AA + + +A L K++ + ++K KKF ++K L L+++ E
Sbjct: 2282 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334
Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
TD K LL+ ++++L+ E E ++V++ S++
Sbjct: 2335 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2371
Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
Q + L +LK+ E A N+++I D Q LQ + EK K+ E
Sbjct: 2372 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2415
Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
+ E L E+ ++ + KM + + A L LL L
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2475
Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
+Q + ++ D ++Q + LAEE + +L L + E R + ++ +
Sbjct: 2476 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531
Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
Q + + + ++ + + +L QE TL+ I R ++ L+
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
LE +++LQ+ + +E+ + +E + E L+ + K + +RFI+
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2647
Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
+ K K + F ++ + Q+ + QR + + QE + RL A +
Sbjct: 2648 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2689
Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
+ + ++ G+ +L QL+ Q ++E+ L E+ +QL EE+H A
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2749
Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
++ A + K L P + E L ++ +QR+++A L E +++L
Sbjct: 2750 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2809
Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
+ T D +E ++ L N+KL Y LQ +L
Sbjct: 2810 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2858
Score = 92.0 bits (227), Expect = 2e-17
Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 740 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 799
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL ++ H++
Sbjct: 800 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 856
Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 857 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 916
Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
L + AK+V Q ++ + L C K +E + + EC L
Sbjct: 917 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 973
Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
+L S S F +P ++A V + A+ L ++ S +
Sbjct: 974 SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 1033
Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
++ + + SL ++K E + ++ L+ L LR+ Q
Sbjct: 1034 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 1078
Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
P E + G + H LLQ+L ++ Q C+ L+
Sbjct: 1079 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1127
Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
D + L A E+ L DKE + + + + +K A +E + L +
Sbjct: 1128 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1183
Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
E L+ L S+++ EQV S + ++ T+ ++ T+
Sbjct: 1184 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1236
Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
+ + + H E+ Q++ A +L+ATK L+ QAE Q
Sbjct: 1237 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1283
Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
L D + ++ E L+ H E + ++++ R ++ + + + +L + +
Sbjct: 1284 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1333
Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
RQ+ +E L +++ S L L+D R + + +
Sbjct: 1334 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1371
Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
SQ + +L + I + V+E + + E +L + LE
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1431
Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
AS + ++ SG + +QE + L L T++ +FI T
Sbjct: 1432 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1479
Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
+E + + Q E+ L E ++++ L + + KE +++ +
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
+ + + K+ S ++LQ E E++ K +Q + E + +
Sbjct: 1540 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588
Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
++R + LQ L+A + Q L R E+A E K+ +
Sbjct: 1589 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1630
Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
+E E L+ ++ E K + +EL+ + E + + +L L +++
Sbjct: 1631 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1679
Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q ++ ++ + E+ A Q QV E A ++ +R + + + +E
Sbjct: 1680 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732
Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
L+E QL + R +A R +E R +E L+A
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1775
Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
E+L + L+ +E VA + L + EA+ Q + +E + A ++A +
Sbjct: 1776 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
QE E +R L +++ + + ET G+ L E L RL++
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1880
Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
A + E EL K+R ++L + R E K L ++ L E A
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
EE K++ + E+ R+ + L E+L I + T E++ +
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1996
Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
EN ++L QR R + + +E + + +++ + ++++ K
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 2048
Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
LV+ +++R +EI+ALK F++
Sbjct: 2049 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 2108
Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
+ +A ++ + E E +Q L ++ K E + E+L+ K E + +
Sbjct: 2109 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2167
Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
+ + A E +++ E + + ++A+++K +E+ L + +L Q +
Sbjct: 2168 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225
Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
E+A+E + + E ++ E + Q EQ +AQ + + Q+ ++
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
RA+ + L + A +ME++ + T +A +E T L D+ +
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
L+ L A+ A Q L S+ + +E+LS I+ + D +
Sbjct: 2346 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402
Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
+QE + + L+Q E L Q + +A+ ++ + + R+
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
+L L++E E+ + + + E + ++T+ Q+E+ +
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
K L V + + ++ + + E TQE+ L++ + Q + D +
Sbjct: 2523 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
E L++ + A+ E Q KL QL+ E + ++Q+L Q + + K
Sbjct: 2582 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637
Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
++L + ++QE+ +E+ V + E+ ++++ + L A EE
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2695
Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
+++ G + + Q + +++ EE++ +++E A+ + T+
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2755
Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
A P+ + GP P + +G + A L + E +++
Sbjct: 2756 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2813
Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
T V + + ++ +LQ A + ++ + L++QL+ G +L E +
Sbjct: 2814 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2871
Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
FLL+ +++ L N A +
Sbjct: 2872 ASGFLLDPVRNRRLTVNEAVK 2892
Score = 84.7 bits (208), Expect = 3e-15
Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)
Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
A L +S GF E+ ++ E +C YQ LL+ L + +E+ D+
Sbjct: 1072 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1130
Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
+ E E+ V L K P E Q+I E + E G AR+ E
Sbjct: 1131 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1185
Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
++ E S A P ++ L + + L++ YL + + L ++E LR
Sbjct: 1186 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1245
Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
+LK+ Q L L+ KA LK + + Q L++ + G L +
Sbjct: 1246 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1304
Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
E W E + +++L Q + L+ R+ Y+ L L +
Sbjct: 1305 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1364
Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
+ P+ D AV E+L++ Q L + +K+ + KQ ++ I
Sbjct: 1365 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1416
Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
KD L + LE + AK+ +++ S+++ T TL + + S+
Sbjct: 1417 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1476
Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
+E + + + E + + VE A+ KQ L + + ER+ ELQ Q ++
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1535
Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
+ + R E EE+++L +++AK + E++ + E +
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
L Q + LQAL + E+Q R QE + ++ K +
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1651
Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
V ++K + +++ +L L E L + +++L ++++ +Q++
Sbjct: 1652 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1702
Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
E ++ + + + + E T L +Q+ +++ Q ++ + R ++ ERA
Sbjct: 1703 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
++ L L+A + L+ + Q K + + +K E+ +++
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1814
Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
+AE Q + + ++ E L + L E L + L ++R T G RQ
Sbjct: 1815 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1869
Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
E LA ++ + T + +L L +R + ++L L S R+++ E+S
Sbjct: 1870 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1926
Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
A +F+ + +E+ R+ A EA+ + +A+++ E + + + + E
Sbjct: 1927 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981
Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
T + E + LK + R++R ++ + E + E+ +
Sbjct: 1982 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033
Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
L++ +DS ++R + L+ + + V+EEI LK ++ A K + L++ +++ +
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 2093
Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
+ + ++L+ QL + + +E EE++ K L EE + +A L ++ +
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153
Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
++++ + +A S +L + +R+ EKA E+ + L + ++
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213
Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
D + + + A E + +V S ++++E ++L+ S Q ++Q
Sbjct: 2214 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2268
Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
Q EK EA QE + AE +++ A + + E++ A E
Sbjct: 2269 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2314
Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
LR+ ++ +L T D + N+L+ E L R K T A + +E + R
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
V + EE ++ R + E ++T +Q+ EK+ ++ A+L + QE
Sbjct: 2372 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2426
Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
+E Q AE+ L+ KM+ K E L Q L +E
Sbjct: 2427 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2478
Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
RL++ K ++ ++ EE ++ L R R E +SA E+ +
Sbjct: 2479 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2527
Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
+ EE Q ++ +EEI + + +E + +T E + + L +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
+ + EK Q LL + +Q V + ET Q S K +R +
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647
Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
Q+ K ++L Q E+ + +E + QQ Q + + Q E + +
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704
Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
+K + + +E+ R + E+ + Q+ E+ R AL +E +++V K+
Sbjct: 2705 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
P+ A + E +GL + + I A+E+Q+ L H+ ++
Sbjct: 2763 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2817
Query: 3736 EL 3737
EL
Sbjct: 2818 EL 2819
Score = 77.0 bits (188), Expect = 6e-13
Identities = 403/2180 (18%), Positives = 791/2180 (36%), Gaps = 340/2180 (15%)
Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Q G++ L +W+E+ E L + + + EE + F + +
Sbjct: 406 QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 465
Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
+ K A +YQ+L EG + P ++E + KL L K++ E
Sbjct: 466 LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 524
Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
RL+ L + + ++ +Q L+S L K +++ V +DLD S
Sbjct: 525 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 584
Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
I F + + + + V + +L+ ++ L+A +A Q Q
Sbjct: 585 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 644
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
+ + P++++ + + + ++++W+ +H+ + V PS +Q+
Sbjct: 645 LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 694
Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
+ L Q +EFR +++ + ++ L +T R + + LG ++ Q+ +
Sbjct: 695 HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 740
Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
+ +++ LE L + + ++ WL +EE + ++
Sbjct: 741 LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 796
Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
+ +L +K K + EL+ + G L ED +R E FQ +++ TQ + QL
Sbjct: 797 ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 848
Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
+++ L+E Y Q + +V +R Y + S V LE L L
Sbjct: 849 CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 901
Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
Q QDE E +L E G L GL +++ K ++ R A+ D Q
Sbjct: 902 QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954
Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
++ QL WK S++ EAA + + EA+ Q
Sbjct: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014
Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
L + + +LA ++ ++ H ++ +AFL
Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074
Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
++S DRL E S +H L SL++ A E + + +S+
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 1126
Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
KD ++LE+ + +H E R+ +Q+K + V L+A++
Sbjct: 1127 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1186
Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
+ L LP A TL R + T LE+ L I L + K + +
Sbjct: 1187 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1235
Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
Q E++ EE LK V +LPEL + + K L A+ Q D+
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295
Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
V + LQ + ++L +RWQ + R+ +++ L RQ + + S +
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1355
Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
L +L D ++ R L Q ++L+ E++ K QR
Sbjct: 1356 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1415
Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
++ E L+T + + ESV + L+ + ++ ++ IK
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
T+ ++ E+++ E + +A+ + L E+ L +++L + Q+ A + K
Sbjct: 1476 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1528
Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
ELQ M+ ++ R E+ + +K+ I++ L +
Sbjct: 1529 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1566
Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
E+ A Q E I E + +LQ + E +E +LQ + + +A
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626
Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
+ E + ++ D Q + SRVK E Q+ + + LR E
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686
Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
L + V Q E +R AE + L+R +++ V
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1742
Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
L +++ A + E + ++ RW+ ++ R++ EE + QK L
Sbjct: 1743 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1796
Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
+ E + AER A +E +E ++ QRQ+ E Q +RLA
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1848
Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
E RL+ +G Q+ L+ + + R T +R+E E + + +
Sbjct: 1849 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905
Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
E S S ++ ++L G +E+ ++ L ++ Q +E DA
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1964
Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
E E R E + R T L++++ +E + + Q ++
Sbjct: 1965 RAEAE---RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 6383 ESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDV-GGSSSHEEDEEGPYYS 6441
+ + L L + + D++ ++ +S E+ G
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 2081
Query: 6442 ALSDVEIPENPEAYLKMTTKT-LKASSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVP 6500
L I N E L+ + L+A+ + ++ E ++ E + V
Sbjct: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQRQLA-------------AEEERRRREAEERVQ 2128
Query: 6501 PVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEM 6560
A + L E R L +QE + ++ + +
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA-----QKR 2183
Query: 6561 IQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 6620
+QA+E + ++Q Q+L + + L + E E + A ++ ++ + Q
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243
Query: 6621 --------EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW-EAAQGA 6671
E LK +A + ++ E L+ E+ + +++ Q +L +AA
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2303
Query: 6672 VDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQ 6731
++ + Q+L Q Q L L L +++ + A E R+ Q
Sbjct: 2304 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-TEAARQRSQ 2362
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQ 6791
+E+EL + Q++ L ++ + + + + ++++ ++++ QV+++ L
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-QVAEEAARLS 2421
Query: 6792 GTQNPASPLPSFDEVDSGDQ 6811
A+ L E D Q
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQ 2441
Score = 61.2 bits (147), Expect = 3e-08
Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)
Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
E + C Q LLQ E+ + + + KD+ + + + + L +E
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151
Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
+RI+ Q+ + + G + + E ++++A S + P ELE + KL
Sbjct: 1152 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1211
Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
E+ +L K I + Q + L ++ + LE+++ +L
Sbjct: 1212 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1271
Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
+ Q+ D +R + E + + ++ + + + R
Sbjct: 1272 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1317
Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
+AQ ++W ++ Q Q +L QL + R++ + +W+ + + E P
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1375
Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
+ SQ R ++ +Q +++ + + ++ C +K+Y ++ L
Sbjct: 1376 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1426
Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
Q V + K+Q +++ ++ T + + +++ E L+ +++ E
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
+ Q+ + +LA AL+ +L +++ ++ A ++ R+ E +R
Sbjct: 1487 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
Q K S+Q LQ+ + Q + R E S+ + + +R Q+
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
E LQ+L+ AE +E + QE +L+ V + + K Q +
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1655
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
++V +A A+ ++ Q LQ + EA RL+Q E + + +++
Sbjct: 1656 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1708
Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
+ + ++Q + +F + ++ L+R Q + L Q+ A E+
Sbjct: 1709 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
E E + L + +RL++ + + ++ +++KE + Q+
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
L E Q + +Q A TA +R + Q + E+
Sbjct: 1821 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1865
Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
QLLE+ L+ + A + + E + + AE+ + + + S +S Q
Sbjct: 1866 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
L+ E E E ++L A + RQR+ + RQ + + + +
Sbjct: 1926 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981
Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
+ L + A+K +E +Q R L + + + R R
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041
Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
LE +K L+ L+ + V I L+ S++ ++E +L + + T+ + +
Sbjct: 2042 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
Q E + +R + L A+ E E E + +K L E E++ L+E++ +KA
Sbjct: 2101 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2153
Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
VE+ L+E+ E + L A ++ + E++ + + V +K +EL L
Sbjct: 2154 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2206
Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
Q E VL + A EE + +++ + E + +LKQ ++ +A
Sbjct: 2207 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2264
Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
+++AA +KL K + R + D + KK E T Q++
Sbjct: 2265 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
+ ++ LR L E++ K ++ D+E+Q+ AE + R Q S E +F++
Sbjct: 2323 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2372
Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
++L D D + E + ++Q R ++ A R
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2430
Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
++ E Q+ L + ++ +++ + +E+L A+E+ +R + + Q
Sbjct: 2431 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
+ ++L TQ + R + + A RLK V E ++ + ++
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549
Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
+ E + + + +++Q +H +E + + R+ QQE L K
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609
Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
+++ V EQL+Q+++ L + +D L + R+ ++ ++ + + + L +
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
E++ + + + E R + + ++ R++ E+EE
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Score = 58.2 bits (139), Expect = 3e-07
Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)
Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
K + E Q+ +D L E+ +Q + + + W + + +++Q V
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329
Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
+ + R +L + ++ Y + AW+++ + A P AD ++R
Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389
Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
+ H V+ ++Q N + + L S+
Sbjct: 1390 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1449
Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
I E +L EL+ + + I E+L +++ R+A+ A+E +
Sbjct: 1450 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1509
Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
+ E +K + +KE+ EE ++ E ++ + K++I E + +L
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1563
Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Q+ + R + + +L +E + L+ +Q + E++ L+
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1623
Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
AQ Q Q E ER+ +Q+ +QRK V+L + V K E E
Sbjct: 1624 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1663
Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
R++ A+ + E + + +ER+L + A E + V + AE
Sbjct: 1664 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1714
Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
QS + + +K + +R+ V + + A+ + E E
Sbjct: 1715 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1770
Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
+ E ++A+ + S AQ E + E+ E A + V + EL Q+
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
+ A + EQ+L+ +A + E + L E + Q EA A
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1882
Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
+ K + ++ L KV+ ++ + +E++ + +KS + EA + L+E
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1938
Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
R + ++ +Q+Q+ E Q+ + + ++ +A +
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1981
Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
A+ + + ++ + +N + E + +L E Q + + + +
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 2034
Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
R + EL+ +ED ++ ++ + + ++ EL L L + S+ E+
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094
Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
L +E + LA E ++ ++ L A LE +
Sbjct: 2095 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
L+ +E + A ++ L+ + + Q E K + + + LQQ+L +
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2208
Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
QSV +QL+ +A+A E AE A+++ E E ++E +L+ +
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2264
Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
RA+ + E++Q+A + E + +++ A H K + + +AQ+E
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2322
Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
Q+L L ++ + +L LQ + E + +EE+ ++++ L
Sbjct: 2323 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378
Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
+ + EN A + +D + L + V E RL E Q + ++
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438
Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
+ A + L E Q V E K E + L K++ E RLQ + +
Sbjct: 2439 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2490
Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
+ QL + + Q TL +++ L +S + + ++ + +E + +
Sbjct: 2491 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545
Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
IG +L K T TL Q + L + +++ + +LQ E
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2605
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
+ EM + Q E S S+ LLQ+ + E +Q D V
Sbjct: 2606 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662
Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
Q L + + ER + E R+ H + RK + L+QL + + E
Sbjct: 2663 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2722
Query: 5178 KIQILNNWLEAQEERLK 5194
+ N L Q + L+
Sbjct: 2723 LLAEENQRLREQLQLLE 2739
Score = 57.8 bits (138), Expect = 4e-07
Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)
Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
+L TY QLE + A + Q E++ +E Y++L EL SQ + + E L
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1479
Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
R+ E+ +Q E L ++ AL ++ Q+
Sbjct: 1480 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1513
Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
H QA A ++ + + + Q E+ R + + K S+Q+ L ++ S AE
Sbjct: 1514 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1569
Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
KA + E AE ++LR E E + + L+ + + LRAR E
Sbjct: 1570 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622
Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
+ ++ L+ V+ K + + S+V +A+ K + + ++
Sbjct: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1678
Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
L QA A+ L+ E A QV LE R +LQS K F E A L
Sbjct: 1679 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1729
Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
E+ L+ +V+ + E ER ++ + ++ + + R NE +L
Sbjct: 1730 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
+ +A+ E + ++ + E R + + R + + LE +
Sbjct: 1787 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1841
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+Q L Q+L +R+ G Q L E + A L+
Sbjct: 1842 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1880
Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
A QK L +L ++ +ME L + KA E S TS++ +
Sbjct: 1881 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1929
Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
A + + L ++ R + E+KR + + AE + RQ
Sbjct: 1930 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1964
Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+L K+ + + TE+E I EA+ ERL+ L + E+ Q+ L
Sbjct: 1965 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 2017
Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
+ Q DIE +LA KA D S L + G L+EDT ++R V +
Sbjct: 2018 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 2063
Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
+ LK S + + E+ + IR +++ + S E + + L
Sbjct: 2064 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 2113
Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
E E E+ +E + + E ++ K + + + Q A QL
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173
Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
Q AQ EAA + Q E K A +Q
Sbjct: 2174 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2197
Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
Q+ ++ Q SVLD+L G + +RAA
Sbjct: 2198 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2228
Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
+ ++ V+ E + E +RL Q +E + A + E E + +
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2286
Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
A++ Q + + EK E+ ++ ++E+ L
Sbjct: 2287 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2325
Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
+L LE+ K +L+ E+ + A Q Q+ + E+ + + E SK
Sbjct: 2326 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2379
Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
L R + + + R D D R Q+ E + + + + L A + R
Sbjct: 2380 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
L + L K + + + A L+A +LL + KE + +LQ+ + M
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2490
Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
QLAE + FQ T+E Q + ++ RL++ A+ ED ++ +E+
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
+ L + EL T + + LV+ + + ++Q +H + + + K++++
Sbjct: 2551 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601
Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
+ +E+ + + + E + LQ + +S ++ + LQ++ + K +L+
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2654
Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
Q+ D++ KA +L + R Q + R V ++E + ++ +
Sbjct: 2655 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704
Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
+ L ++E + + ++Q ++++L ++ R HS A +++
Sbjct: 2705 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764
Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
N D L D A E E S D R + A ++ + EE RL Q
Sbjct: 2765 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814
Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
+D+ +R ED +L+ A +L + E+L + A QRQ+ T L L+
Sbjct: 2815 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2868
Query: 6198 KQ 6199
Q
Sbjct: 2869 AQ 2870
Score = 53.1 bits (126), Expect = 9e-06
Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)
Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
L WLQ A E + + Q + +QL QA+L EIE + E + N
Sbjct: 1356 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1415
Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
+E L+L T K LE V S + P + S + + SEL
Sbjct: 1416 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1463
Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
++ ++ +F + ++ +++++ E + E+++ + +E +K H Q
Sbjct: 1464 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1523
Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
E A + +V ++ + Q Q ++ Q L ++I+ Q E
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1582
Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
+ + I + + + TE + +L+ LR A + Q+ +E L +++
Sbjct: 1583 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1640
Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
Q S + E+ R + + AL+ L++L L + + L +A
Sbjct: 1641 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1693
Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
+E +QV LE Q +A +S +A S+ + +L L +
Sbjct: 1694 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1738
Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
++ Q E + A+Q +A+ E E R +E RL L +EV + +
Sbjct: 1739 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1793
Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
+ + + E++++A +G E + + +LA L++ + A
Sbjct: 1794 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1842
Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
Q Q+L A+ LI+ + ET EQ + ++LEE+ + +
Sbjct: 1843 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1881
Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
+ QK +E + A + ++E+L L S + EE T E+ +R+ R +
Sbjct: 1882 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
+ ARL E K QL + + L E+ ++ E RL+ + L
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1993
Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
++++L + E +EQ+ D++ + + + E++ + L
Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 2051
Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
+ + ++L LK A A+ E + + + D Q ++E R
Sbjct: 2052 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110
Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
+ E E + + +A Q K L++ + + +++ + + + Q S
Sbjct: 2111 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169
Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
QL +++ + E H + ++ + L ++ L+QL + +
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2228
Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
EA+E R+ + Q V ++L ++ A A ++L+
Sbjct: 2229 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
Q+ L + A +E ++ ++++ V ++ L+ ++ + + D
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
+E+ + V L ++R Q+E L L+ E+ + +
Sbjct: 2344 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400
Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
LQE K+K + A + Q + + +A Q A+ +L K A
Sbjct: 2401 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2456
Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
E A RLK + QQ ++ L E Q + E Q+T EA Q
Sbjct: 2457 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2511
Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
+L AE+ L R A + + + + Q ++ G +L + L
Sbjct: 2512 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2560
Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
E+ L + + +++ D + A+ + E L + + L L ++T+Q
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2618
Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
L+ LQ L+EK L E++I Q K+E+ + +VA + EQ
Sbjct: 2619 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2671
Query: 5631 QKTYKMLEAE 5640
Q+ + +E E
Sbjct: 2672 QRQQQQMEQE 2681
Score = 39.7 bits (91), Expect = 0.11
Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)
Query: 593 ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
EN RL R +E ++ ++E + A A L +A + +E +V +
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 2058
Query: 647 -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
+ +E+ L + K + K +LE+ L + N+ + L +E+A +E +
Sbjct: 2059 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 2110
Query: 705 SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
+ E + +A E+ +K EE Q K A ++VE+L +VE EA+ + ++
Sbjct: 2111 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2165
Query: 761 DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
+ +++ E + K L A+ + + E LQ +Q S E+ +
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225
Query: 807 VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
+A++Q +E Q V+ LK + + + E+ +KE E R
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 864 AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
Q L Q+++ + KHK+ A + +L L+ + KN + E+
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 911 IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
++ L+ ++ + + + EL S+ VQ ++ K ++ DN + +
Sbjct: 2346 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404
Query: 959 QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
+ ++ K + + + EA +EE Q L M+ ++E
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2464
Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
E L QK +Q++ +RL +D EQ ++L A T + T+
Sbjct: 2465 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2510
Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
R + +EA K ++ + +A E +F Q E I EK + +
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2563
Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
+L++ + R +H + + I +E + + LQ K ++Q ++ E
Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2619
Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
+L +++ F + E+D+L +RER ++
Sbjct: 2620 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2647
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
sapiens]
Length = 1369
Score = 202 bits (515), Expect = 7e-51
Identities = 143/455 (31%), Positives = 225/455 (49%), Gaps = 55/455 (12%)
Query: 28 EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
E++ QKK T W+N L + + ISDL+ D++ GH L+ LLEVLSG LPR+KG
Sbjct: 172 ERDRVQKKTSTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 229
Query: 88 FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
F N++ AL +LR+R +KL+NI DI DGNP + LGLIWTIILHF I
Sbjct: 230 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 279
Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
D+ V S M+A++ LLLW+Q Y+ + +F
Sbjct: 280 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 317
Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
SSWR+G F AIIH +P LIDM V ++N +NL +AF +AE++L + RLL+PEDVDV
Sbjct: 318 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 377
Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
PDEKSI+TYV+ P + + + + W ++ L L + F+
Sbjct: 378 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 436
Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
+ F SF E + + L K +L + D + + + L+ + A ++K
Sbjct: 437 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 489
Query: 387 ALPP---PLHQTEAWLQEVEELMDED--LSASQDHSQAVTLIQEKMTLFKSLMDRFEHHS 441
+PP PL + W + +++ + L + + + + I K+ + L + H +
Sbjct: 490 -VPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQA 548
Query: 442 NILLTFENKDENHLPLVPPNKLEEMKRRINNILEK 476
+ LL ++ + L+ K+ + + L+K
Sbjct: 549 DALL------QSDIRLLAAGKVPQRAGEVERDLDK 577
Score = 35.0 bits (79), Expect = 2.6
Identities = 46/210 (21%), Positives = 83/210 (39%), Gaps = 4/210 (1%)
Query: 6057 QEIQKRLAEQQDLQRDIEQHSAGVESVFNICD-VLLHDSDACANETECDSIQQTTRSLDR 6115
+E +R+AEQQ Q ++E GV + + VL + A T ++ T L+
Sbjct: 1150 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE- 1208
Query: 6116 RWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
+ R++ A+ +E+ I R Q + E+ LK A+ A E S K+
Sbjct: 1209 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1268
Query: 6176 LKRFEAFQRQIHERLTQLELINKQYRRLAREN--RTDTASRLKQMVHEGNQRWDNLQRRV 6233
+ EA Q +L + RL + + R R ++ V + +RW + +
Sbjct: 1269 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1328
Query: 6234 TAVLRRLRHFTNQREEFEGTRESILVWLTE 6263
R L Q + + + + WL +
Sbjct: 1329 DVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
Score = 33.5 bits (75), Expect = 7.5
Identities = 42/194 (21%), Positives = 79/194 (40%), Gaps = 17/194 (8%)
Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
KLL + L+S E L LM + K+++E GF A+ + Y +
Sbjct: 736 KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 795
Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
++ + +KEL++ G+ LL + E + S + QL + + H++
Sbjct: 796 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI---EAHLK 852
Query: 2250 EHDSYQVCVTDLNTTLDNFSK-----EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDG 2304
E+ +Y +D+ K + D+ +E+ LQ Q+ + +L+ G
Sbjct: 853 ENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 912
Query: 2305 TLKKILALAKSVKQ 2318
L + AK+V Q
Sbjct: 913 HLSGLAKRAKAVVQ 926
Score = 33.1 bits (74), Expect = 9.8
Identities = 80/406 (19%), Positives = 148/406 (36%), Gaps = 47/406 (11%)
Query: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLE 5482
EIL KE++ KEA S + + + A + + +P H L
Sbjct: 448 EILWSQFLKFKEME---LPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWG 504
Query: 5483 KMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALT 5542
K+ + + + S+F+ RLE L+ ++ + L +++ D+ L + L
Sbjct: 505 KLHVAILEREKQLRSEFE----RLECLQRIVTKLQMEAG-LCEEQLHQADALLQSDIRLL 559
Query: 5543 AQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCC 5602
A + EV L +D ++ L N L+ QG + +
Sbjct: 560 AAGKVPQRAGEVERDLDKADSMIRLLFN--------DVQTLKDGRHPQGEQMYRRVYRLH 611
Query: 5603 EKWIQLLEKIEEALKVDVANSLPELLEQ--QKTYKMLEAEVSINQTIAD--SYVTQSLQL 5658
E+ + + + LK VA ++ + Q + E E S + + D ++V ++
Sbjct: 612 ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 671
Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
+D E W + V + G GL + ++F +E R +D
Sbjct: 672 VDGAE-----------------WGVDLPSVEAQLGSHRGLHQSIEEFQAKIE---RARSD 711
Query: 5719 TSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE 5778
L A +G R L + +L N R + + A K L+ + K +E
Sbjct: 712 EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 771
Query: 5779 SVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKS 5824
VG W D + + + + + + EKKIKEL++
Sbjct: 772 EVGF-------DWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 810
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 202 bits (513), Expect = 1e-50
Identities = 145/454 (31%), Positives = 225/454 (49%), Gaps = 80/454 (17%)
Query: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD-K 83
LQ E+E QKK FT W+NS LAR + I+DL+TD++ G +L+ LLEVLSG++LP+ K
Sbjct: 35 LQDEREAVQKKTFTKWVNSHLARVSCR--ITDLYTDLRDGRMLIKLLEVLSGERLPKPTK 92
Query: 84 GSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQT 143
G C N++ AL FL+ + + L N+ DI+DGN + LGLIWTIIL F I+ ++
Sbjct: 93 GRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVE 152
Query: 144 LSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNV 203
N + + SA+ ALLLW Q + A Y +VN+
Sbjct: 153 TEDN------------------------------KEKKSAKDALLLWCQMKTAGYPNVNI 182
Query: 204 TDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPED 263
+F +SWR+GMAF A+IH RPDLID +K + NL+ AF +AEQ L + +LL+PED
Sbjct: 183 HNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPED 242
Query: 264 VDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDS-EN 322
+ V PDEKSI+TYV + Y M L ++ +++ K+L ++ E
Sbjct: 243 ISVDHPDEKSIITYVVTYYHYF---------------SKMKALAVEGKRIGKVLDNAIET 287
Query: 323 DTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAWDGLDHQINAWKI 382
+ +KY SL S + + E+ L ++ + + G+ Q+ A+
Sbjct: 288 EKMIEKYESLASDLLEWIEQTIIIL--------------NNRKFANSLVGVQQQLQAFNT 333
Query: 383 KLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFK-----SLMDRF 437
PP + +E L+ S + ++Q V + +E + +++
Sbjct: 334 YRTVEKPPKFTEK----GNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA 389
Query: 438 EHHSNILLTFENKDENHLPLVPPNKLEEMKRRIN 471
EH + L E L+ KLE++ RR +
Sbjct: 390 EHERELALRNE--------LIRQEKLEQLARRFD 415
Score = 99.0 bits (245), Expect = 1e-19
Identities = 303/1650 (18%), Positives = 640/1650 (38%), Gaps = 218/1650 (13%)
Query: 4817 TEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLE-------ILISTLPSVSLVEE 4869
+++K L + ++ G L + ++ E+ E Y SL DL I+++ + +
Sbjct: 265 SKMKALAVEGKRIGKVLDNAIET-EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 323
Query: 4870 TEERLVERISFYQQIKR-----NIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQ 4924
+++L + + Y+ +++ G L+ ++ + V P I+ + +
Sbjct: 324 VQQQL-QAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKA 382
Query: 4925 WLSLNKK-------IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNV 4977
W L K + +EL R + L + ++R + WL +Q ++ N
Sbjct: 383 WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS-----QDNF 437
Query: 4978 SQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
DL + + ++ AV+++ +L D + A + W
Sbjct: 438 GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLW 497
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMI---SWMNNVEHQTSDEDSVHSPSSASQV 5094
L+ L +++L L +K EM+ WM+ ++ +D V
Sbjct: 498 EYLLELLRARRQRLEM----NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY---GKHLLGV 550
Query: 5095 KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRV 5154
+ LLQKH ++ + V VN S + +T K + + + M + +
Sbjct: 551 EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 610
Query: 5155 HGMLNRKIQHLEQ---LLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
+ + LE+ L + E + W+ +E+ L + + + SV +LL
Sbjct: 611 CQLAAERRARLEESRRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLLSK 666
Query: 5212 CQDIENQLAIKS----KALDELKQSYLTLESGAVPLLE------------DTASRIDELF 5255
+ E++++ +S +A+ E + G+ + E + S I +
Sbjct: 667 HRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKR 726
Query: 5256 QKRSSVLTQ----VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
+ +S+L Q + + M +L+ D +DE + ++ ++ K V +
Sbjct: 727 LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSL-----VKKHKDVAEEIA 781
Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQ 5371
R L +L ++A + + +V G+L G+ +R+ +V +
Sbjct: 782 NYR---PTLDTLHEQASALPQEHAESPDVRGRLSGI---------------EERYKEVAE 823
Query: 5372 AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQD 5431
+ Q Q L L+K +S A A L E K Q L N+ +P L+D
Sbjct: 824 LTRLRKQALQDTLALYKMFSEAD---ACELWIDE-KEQWLNNMQ---------IPEKLED 870
Query: 5432 IKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANE 5491
++ +QH + + +S + + Q A H P S + + L + ++
Sbjct: 871 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP----SEKEIKAQQDKLNTRWSQ 926
Query: 5492 FEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEK-----ENPDSFLNHVLALTAQSP 5546
F ++ + KD + S++ + E + ++ K ++ + L V+AL +
Sbjct: 927 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986
Query: 5547 DIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWI 5606
+E + V+++ LSD+ K + + + L R +E+ + E+
Sbjct: 987 GMER-DLVAIEAKLSDLQ-KEAEKLESEHPDQAQAILSRLAEISDVW---------EEMK 1035
Query: 5607 QLLEKIEEALKVDVANSLPELLEQQKTYK--MLEAEVSINQTIADSYVTQSLQLLDT--- 5661
L+ E +L A+ L + L ++ + + +I + +T++ +LL
Sbjct: 1036 TTLKNREASL--GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN 1093
Query: 5662 --TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT 5719
EI+N E ++ K+ D + QG Q L ++ Q T L + +
Sbjct: 1094 IKNEIDNYEE---DYQKMRDMGEMVTQG--QTDAQYMFLRQRLQALDTGWNELHKMWENR 1148
Query: 5720 SHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTD--LKTK 5777
+LLS ++F L T+ L N+E + T TLE E + + + T
Sbjct: 1149 QNLLSQSHAYQQF-LRDTKQAEAFLNNQE--YVLAHTEMPTTLEGAEAAIKKQEDFMTTM 1205
Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPL 5837
++ +I+ + ++ + + + Q V++ D +K +E S L +++ + L
Sbjct: 1206 DANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASEL-LMRLKDNRDL 1264
Query: 5838 PELHEDLH------NEKELIK------ELEQSLASWTQN---LKELQTMKADLTR----- 5877
+ +D NEK L E + W ++ + EL + K L +
Sbjct: 1265 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG 1324
Query: 5878 ----HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
E V+KE++ LH+ WE L + Q + D N +F + +L WL
Sbjct: 1325 MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWL 1383
Query: 5934 VQMENKVLQTADIS--IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA- 5990
+E+++ Q+ D + + L+K M E N K +++++ Q S + ++
Sbjct: 1384 HGLESQI-QSDDYGKDLTSVNILLKKQQMLE-NQMEVRKKEIEELQSQAQALSQEGKSTD 1441
Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA-RIESELSKPV 6049
E+D K + ++ L + + R L + I Q ++++ + W+ R+ S
Sbjct: 1442 EVDSKRLTVQTKFMELLEPLNERKHNLLASKE-IHQFNRDVEDEILWVGERMPLATSTDH 1500
Query: 6050 VYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
+++ Q +Q + + Q LQ++I+ H ++ +F ++ DS + + E +I+Q
Sbjct: 1501 GHNL---QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE----AIRQR 1553
Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
L + W + + +R ++EE R Q++ D + E W+ E ++
Sbjct: 1554 LADLKQLWGLLIEETEKRHRRLEEAHRA-QQYYFDAAEAEAWMSEQELYMMSEEKAKD-E 1611
Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTA-------------SRLK 6216
SA LK+ + ++ + + + ++K R L ++ ++ + LK
Sbjct: 1612 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK 1671
Query: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE 6276
+ E + D R L +L + E++ RE ++ E+ +V E
Sbjct: 1672 DLAEERRGKLDERHR-----LFQLNREVDDLEQWIAERE-VVAGSHELGQDYEHVTMLQE 1725
Query: 6277 SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQ------------------LIQKSEPLD 6318
+ N Q+ + + D+LI G L++ +
Sbjct: 1726 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1785
Query: 6319 AVLIED-ELEELHRYCQEVFGRVSRFHRRL 6347
+L EL + + +E+FGR+ H++L
Sbjct: 1786 QILAASYELHKFYHDAKEIFGRIQDKHKKL 1815
Score = 83.6 bits (205), Expect = 6e-15
Identities = 226/1304 (17%), Positives = 502/1304 (38%), Gaps = 152/1304 (11%)
Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
+K +ER E AEH E+ L ++ E+L + + K + WL +
Sbjct: 380 NKAWERLEKAEHEREL---------ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 430
Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG------AVPLLE 5245
+ + +V+ + IE +A + + + LE+ + +
Sbjct: 431 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490
Query: 5246 DTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKP 5305
D R+ E + Q ++ +Q + QE DE+ ++ + ++ K
Sbjct: 491 DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLS----QDYGKH 546
Query: 5306 VVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKR 5365
++ + L+ + +AE G Q+ +G P ++I ++ +
Sbjct: 547 LLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFC 606
Query: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
+ ++ Q A++ + + +LWK + E ++++E ++ + G +L ++
Sbjct: 607 YQELCQLAAERRARLEESRRLWKFFWEM-AEEEGWIREKE----KILSSDDYGKDLTSVM 661
Query: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKML 5485
L + + ++ F Q + + + + ++ ++ A LE++
Sbjct: 662 R-LLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLS 720
Query: 5486 LVKANEFE--FVLSQFK----DFGVRLESLKGLIM-----HEEENLDRLHQQEKENPDSF 5534
++ E +L QF+ D + + ++ H+E + L ++ K+ +
Sbjct: 721 AIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI 780
Query: 5535 LNH-----VLALTAQSPDIEHLNEVSLKLPLSDVA-----VKTLQNMNRQWIRATATALE 5584
N+ L A + EH ++ LS + V L + +Q ++ T +
Sbjct: 781 ANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYK 840
Query: 5585 RCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
SE CE WI EK + + + L +L Q ++ LE E++ N
Sbjct: 841 MFSEADA----------CELWID--EKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMN-N 887
Query: 5645 QTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQD 5704
Q + V Q + L + + E + KL RW + V ++K D L+
Sbjct: 888 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKK---DALLS---- 940
Query: 5705 FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEA 5764
S++N +T + ++ + T+ L ++L + QR+ T L A
Sbjct: 941 -ALSIQNYHLECNETKSWIR----EKTKVIESTQDLGNDLAGV-MALQRKLTGMERDLVA 994
Query: 5765 GEKLLLTTDLKTK------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETW 5812
E L +DL+ + +++ R++++ D W++M+ L K ++++
Sbjct: 995 IEAKL--SDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTL----KNREASLGEA 1048
Query: 5813 DQCEKKIKELK------SRLQVLKAQSEDP--------LPELHEDLHNEKELIKELEQSL 5858
+ ++ +++L SR Q A + P L HE++ NE + +E Q +
Sbjct: 1049 SKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM 1108
Query: 5859 ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
+ + + QT D L + + L LH+ WE+ +Q + + +
Sbjct: 1109 RDMGEMVTQGQT---DAQYMFLRQRLQALDTGWNELHKMWEN--------RQNLLSQSHA 1157
Query: 5919 WVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE---KLQKDCMEEINLFSENKLQLKQ 5975
+ F K+ A+L E + T + E E K Q+D M ++ E + +
Sbjct: 1158 YQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVE 1217
Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
G +L+ N + + I +K++ I+DR + + + +LK+ +Q+ ++ L
Sbjct: 1218 TGRRLVSDGNIN-SDRIQEKVDSIDDRHRKNRETASELLMRLKDN-RDLQKFLQDCQELS 1275
Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
W+ + ++ + YD + + + + + Q ++ + ++ + L+ +
Sbjct: 1276 LWINE-KMLTAQDMSYD--EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKP 1332
Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
ETE +++ L + W + + + + ++ + + + F + + WL
Sbjct: 1333 ----ETEA-VVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGL 1386
Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAREN-------- 6207
E + + L TS LK+ + + Q+ R ++E + Q + L++E
Sbjct: 1387 ESQIQSDDYGKDL-TSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1445
Query: 6208 -RTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDL 6266
R ++ +++ N+R NL + + +F E ++W+ E
Sbjct: 1446 KRLTVQTKFMELLEPLNERKHNLLA------------SKEIHQFNRDVEDEILWVGERMP 1493
Query: 6267 QLTNVEHFSESDADDKMRQLNG-FQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDE 6325
T+ +H + + N Q+EI + +ID + + ++ S L A I
Sbjct: 1494 LATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQR 1553
Query: 6326 LEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED 6369
L +L + + + HRRL + +A+E E M +
Sbjct: 1554 LADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1597
Score = 78.2 bits (191), Expect = 3e-13
Identities = 173/872 (19%), Positives = 347/872 (39%), Gaps = 156/872 (17%)
Query: 4657 QQSLNEISGQSVAEQLQ----KADAYTVELENAESRVAKLRDEGERL-HLPYALLQEVYK 4711
+Q LN + E L+ + ++ E+ N SRVA + +L H + +E+
Sbjct: 856 EQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915
Query: 4712 LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMV----------------ELVKI-- 4753
+D L++ W R + + ++DALL + E K+
Sbjct: 916 QQDKLNTRWSQFRE---------LVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 966
Query: 4754 ----------GKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPS 4803
G L + VA++A++ + + +KL ++ A+ + S
Sbjct: 967 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE----HPDQAQAILS 1022
Query: 4804 LLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPS 4863
L W E T +K E + KLQ L+ ++F S + I++
Sbjct: 1023 RLAEISDVWEEMKTTLKNREASLGEAS-KLQQFLRDLDDFQ----SWLSRTQTAIASEDM 1077
Query: 4864 VSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEE 4923
+ + E E+ L + ++ IK I + YQ + + ++V +GQ +
Sbjct: 1078 PNTLTEAEKLLTQ----HENIKNEIDN-YEEDYQKMRDMGEMVT-------QGQT---DA 1122
Query: 4924 QWLSLNKKID------HELHRLQALLKHLLSYN-------RDSDQLTKWLESSQHTLNYW 4970
Q++ L +++ +ELH++ ++LLS + RD+ Q +L + ++ L +
Sbjct: 1123 QYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHT 1182
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+ + L+ + I +F +D AV+ G +L+ ++ ++ +
Sbjct: 1183 E-----MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1237
Query: 5031 AQFEQKWT----------MLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080
+ + M + D+Q+ L Q E+ W+N E +
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-----------ELSLWIN--EKMLT 1284
Query: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEM-DYKQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
+D + + K L KH+ F E+ K+W+ D + + +QL + K
Sbjct: 1285 AQDMSYDEARNLHSKWL--KHQAFMAELASNKEWL-DKIEKEGMQL----ISEKPETEAV 1337
Query: 5140 FAEHLGEMNRQWHRVHGMLNRKIQHL--EQLLESITESENKIQILNNWLEAQEERLKTLQ 5197
E L +++ W + K Q L E T+S L+ WL E ++++
Sbjct: 1338 VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQS---CADLDKWLHGLESQIQSDD 1394
Query: 5198 KPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
+ + SV LL Q +ENQ+ ++ K ++EL+ L DE+ K
Sbjct: 1395 YGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ--------AQALSQEGKSTDEVDSK 1446
Query: 5258 RSSVLTQ-------VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSL 5310
R +V T+ +N+ K ++ + + + + DE+ + R + S +L
Sbjct: 1447 RLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERM--PLATSTDHGHNL 1504
Query: 5311 ETLRCQVENLQSLQDEAESS----EGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
+T++ ++ Q+LQ E + + +E+ Q ++ L AE I ++ + + W
Sbjct: 1505 QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS---AEAIRQRLADLKQLW 1561
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQE--------AKFQQLANISMSG 5418
+ + + ++ + + + Y +A EA A + +QE AK +Q A +SM
Sbjct: 1562 GLLIEETEKRHRRLEEAHRAQQYYFDA-AEAEAWMSEQELYMMSEEKAKDEQSA-VSMLK 1619
Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNS 5450
+ +IL A++D E H + KT A + +S
Sbjct: 1620 KH--QILEQAVEDYAETVHQLSKTSRALVADS 1649
Score = 77.8 bits (190), Expect = 3e-13
Identities = 265/1440 (18%), Positives = 537/1440 (37%), Gaps = 197/1440 (13%)
Query: 4959 WLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL 5018
W+ + L+ S + +DL ++ ++ F E+ +S I G ++
Sbjct: 640 WIREKEKILS-----SDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE 694
Query: 5019 KETDTATLRASLAQFEQKWTMLITQLPDIQEK-------LHQLQMEKLPSRKAITEMISW 5071
+ + +R + ++W L QL I++K LHQ Q + ++ +W
Sbjct: 695 EHFGSEKIRERIIYIREQWANL-EQLSAIRKKRLEEASLLHQFQADA-------DDIDAW 746
Query: 5072 MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE 5131
M ++ S D H S L++KHK+ E+ + +D +++ L E
Sbjct: 747 MLDILKIVSSSDVGHDEYSTQS---LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE 803
Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
S + L + ++ V + + Q L+ L ++ + ++ W++ +E+
Sbjct: 804 SP-----DVRGRLSGIEERYKEVAELTRLRKQALQDTL-ALYKMFSEADACELWIDEKEQ 857
Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRI 5251
L +Q PE + ++ + + +E ++ ++ + + Q L P ++ ++
Sbjct: 858 WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 917
Query: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
D+L + S V++ K ++ S L + Y +E +E ++ + L
Sbjct: 918 DKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLA 976
Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQV-- 5369
+ L ++ + + E LQ+ KL+ P A+ I + W ++
Sbjct: 977 GVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKT 1036
Query: 5370 ----NQAIADQLQKAQSLL------QLWKAYS----------NAHGEAAARLKQQE---- 5405
+A + K Q L Q W + + N EA L Q E
Sbjct: 1037 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1096
Query: 5406 ---------AKFQQLANISMSGNNLAE--ILPPALQDI----KELQHDVQKTKEAFLQNS 5450
K + + + G A+ L LQ + EL H + + ++ L S
Sbjct: 1097 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWENRQNLLSQS 1155
Query: 5451 SVLDRLPQPAESS-----------THMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
+ + + + H +P L + A ++ + + E ++
Sbjct: 1156 HAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAV 1215
Query: 5500 KDFGVRLESLKGL----IMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS 5555
+ G RL S + I + +++D H++ +E L + ++ E+S
Sbjct: 1216 VETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELS 1275
Query: 5556 L-----KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLE 5610
L L D++ +N++ +W++ A E S ++W+ +E
Sbjct: 1276 LWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASN--------------KEWLDKIE 1321
Query: 5611 KIEEALKVDVANSLPELLEQQK---TYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENR 5667
K E +++ E + ++K +KM E S QT A +L D N+
Sbjct: 1322 K--EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ-------RLFDA----NK 1368
Query: 5668 PEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
E T+ D+W + ++ Q + D G +D TSV L + + + K
Sbjct: 1369 AELFTQSCADLDKWLHGLES--QIQSDDYG-----KDL-TSVNILLKKQQMLENQMEVRK 1420
Query: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQL 5787
+ Q ++L E K+ + +R T +E E L + K + I Q
Sbjct: 1421 KEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL---NERKHNLLASKEIHQF 1477
Query: 5788 QDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNE 5847
+D + E + ST + + ++ L + Q L+ + + P + +
Sbjct: 1478 NRDVEDEILWVGERMPLATSTDHGHNL--QTVQLLIKKNQTLQKEIQGHQPRIDDIFERS 1535
Query: 5848 KELIKELEQ-SLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
+ ++ + S + Q L +L+ + +L E+ E HR+ E+ A
Sbjct: 1536 QNIVTDSSSLSAEAIRQRLADLKQLWG------------LLIEETEKRHRRLEE-----A 1578
Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEE-MIEKLQKDCMEE--I 5963
R Q+ F+ E AW+ + E ++ E+ + L+K + E +
Sbjct: 1579 HRAQQ--------YYFDAAEAE--AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAV 1628
Query: 5964 NLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAF 6023
++E QL + L+ A + + I + +K++ + L D+ R KL E
Sbjct: 1629 EDYAETVHQLSKTSRALV-ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1687
Query: 6024 IQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQ-QDLQRDIEQHSAGVES 6082
QL++ + +L W+A E +++ D E L E+ ++ RD + G E
Sbjct: 1688 F-QLNREVDDLEQWIAEREVVAGS---HELGQDYEHVTMLQERFREFARD--TGNIGQER 1741
Query: 6083 VFNICDVLLHDSDACANETECD--SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQK 6140
V D + H +D N D +I + L+ W ++ + R + ++ L K
Sbjct: 1742 V----DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL-HK 1796
Query: 6141 FLDD----YSRFED-WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLEL 6195
F D + R +D K E N+ E L + F+ I TQ+
Sbjct: 1797 FYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ-------RMHTTFEHDIQALGTQVRQ 1849
Query: 6196 INKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHF-TNQREEFEGTR 6254
+ + RL D A +++ +E + W +L + RR+R T + F
Sbjct: 1850 LQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACES--RRVRLVDTGDKFRFFSMV 1907
Query: 6255 ESILVWLTEMDLQLTNVEHFSE-SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
+++W+ ++ Q+ E + S + M G + EI + I G+ L+ +
Sbjct: 1908 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1967
Score = 48.9 bits (115), Expect = 2e-04
Identities = 177/879 (20%), Positives = 349/879 (39%), Gaps = 166/879 (18%)
Query: 2949 HEKTSAL-QEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
HE+ SAL QE A+S L G+ EE Y LT ++ LQ D
Sbjct: 791 HEQASALPQEHAESPDVRGRL------SGI-EERYKEVAELTRLRKQALQ--------DT 835
Query: 3008 IGLNWDFSQLDQLQTQVFEKEK-----ELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQI 3062
+ L FS+ D + + EKE+ ++ EK++ L+ + ++++L +M ++
Sbjct: 836 LALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQH---RFESLEPEMNNQASRV 892
Query: 3063 KKMTEVVLKAPDSS-PESRRLNAQI--LSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKE 3119
+ ++ + S P + + AQ L+ R + + L D KK E
Sbjct: 893 AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR--KKDALLSALSIQNYHLE 950
Query: 3120 ILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLIN 3179
+ K E K+ + Q++ +L+ ++ +E L + S LQ+
Sbjct: 951 CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG-MERDLVAIEAKLSDLQKEAE-K 1008
Query: 3180 LEIKHIQNEKDNCEAFQE--QVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQ 3237
LE +H + E VW EM + K RE + EAS ++ LR+ +D Q
Sbjct: 1009 LESEHPDQAQAILSRLAEISDVWEEMKTTL------KNREASLGEASKLQQFLRDLDDFQ 1062
Query: 3238 MQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPL 3297
L+ + +T + ++ N +T A + +T E I + ++ N EE + +
Sbjct: 1063 SWLSRT---QTAIASEDMPN------TLTEAEKLLTQHENI----KNEIDNYEEDYQ-KM 1108
Query: 3298 RKQEELES---TVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEA 3354
R E+ + T A L ++L + + +L + ++ + S + F +A
Sbjct: 1109 RDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQA 1168
Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQS---MSSLPLSYREALERLEQSKALVS--- 3408
E +L N + Y ++ T L E + + M+++ + + +E + LVS
Sbjct: 1169 EAFLNNQE-YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN 1227
Query: 3409 -------------------NLISTKEELMKLR--QILRLLRLRCTENDGICLLKIVSA-- 3445
N + E LM+L+ + L+ C E K+++A
Sbjct: 1228 INSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQD 1287
Query: 3446 --------LWEKWLS----LLEAAKEWEMWCEELKQE-WKFVSEEIEREAII------LD 3486
L KWL + E A E W +++++E + +SE+ E EA++ L
Sbjct: 1288 MSYDEARNLHSKWLKHQAFMAELASNKE-WLDKIEKEGMQLISEKPETEAVVKEKLTGLH 1346
Query: 3487 NLQEELPEISKTK-EAATTEELSELLDCLC-----------------QYGEN-------V 3521
+ E L ++TK + +EL C YG++ +
Sbjct: 1347 KMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL 1406
Query: 3522 EKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTE 3581
+KQQ+L + R + I+ + + A+ QE S E +K L K EL++
Sbjct: 1407 KKQQMLENQMEVRKKEIEELQSQAQALS-----QEGKSTDEVDSKRLTVQTKFMELLEPL 1461
Query: 3582 IQERHSF--TKEIIAL-KNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
+ +H+ +KEI ++ + + M + + +Q ++KK +
Sbjct: 1462 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQ------ 1515
Query: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSS--PSYAMRRKIEEIN 3696
++ +++ + ++DI E+ N V SS + A+R+++ ++
Sbjct: 1516 -----------------TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLK 1558
Query: 3697 NGLHNVEKMLQQKSKNIEKAQEIQKKMWD--ELDLWHSK 3733
+ + +++ + +E+A Q+ +D E + W S+
Sbjct: 1559 QLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1597
Score = 47.4 bits (111), Expect = 5e-04
Identities = 253/1414 (17%), Positives = 540/1414 (38%), Gaps = 231/1414 (16%)
Query: 1464 KHRKKSLIRLDKVLDE----YEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENT 1519
++ +SL++ K + E Y L E A++LP + V + ++
Sbjct: 763 EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEERYKEV 821
Query: 1520 KALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEI 1579
L + L L K + + + +KE+ + ++Q E+L+ E
Sbjct: 822 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEK-LEDLEVIQHRFES 880
Query: 1580 VKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD----RWLDINEKTE 1635
++ E N V +NQ+ + L P EKE D RW E +
Sbjct: 881 LEPEMNNQASRVAVVNQIARQLMH--------SGHPSEKEIKAQQDKLNTRWSQFRELVD 932
Query: 1636 DYYENLGRALALWDKLFNLK-NVIDEWTEKALQKMELHQLTEEDRER----------LKE 1684
+ L AL++ + ++L+ N W + + +E Q D ++
Sbjct: 933 RKKDALLSALSIQN--YHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 990
Query: 1685 ELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALS 1744
+L E K S+ + +++ SE P + Q + S + + ++ T N A
Sbjct: 991 DLVAIEAKLSDLQKEAEKLE-----SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1045
Query: 1745 GSTAELRE---DLDQAKTQIGMTESLLKALSPSDSL----EIFTKLEEIQQQI------L 1791
G ++L++ DLD ++ + T++ + + ++L ++ T+ E I+ +I
Sbjct: 1046 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY 1105
Query: 1792 QQKHSM-------------ILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
Q+ M + L ++ L +EL K +E+ +L + Q H +
Sbjct: 1106 QKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLS------QSHAYQ 1159
Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
K + +N + L E T + E ++K DF+T N + ++++V+
Sbjct: 1160 QFLRDTKQAEAFLNNQEYVLAHT-EMPTTLEGAEAAIKKQEDFMTTMDANEE--KINAVV 1216
Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
+ ++ + ++ + EK++SI K E + + L+RL+ D+R+L+K+
Sbjct: 1217 ETGRRLVSDGNINS--------DRIQEKVDSIDDRHRKNRETASELLMRLK-DNRDLQKF 1267
Query: 1959 LTNQEE------------------KWKGMEEPGEKTELFCQALARKREQFESVAQLNNSL 2000
L + +E + + + K + F LA +E + + + L
Sbjct: 1268 LQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQL 1327
Query: 2001 KEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
E E ++ E + + +L ++ + + + + F D+ W+ +
Sbjct: 1328 ISEK-PETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGL 1386
Query: 2061 KE------------SLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE-SS 2107
+ S+ +L + + + ++K KEI L+ + A + E S
Sbjct: 1387 ESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRK-KEIEELQSQAQALSQEGKSTDEVDS 1445
Query: 2108 EAPLVQKTLTDISNQWDNTLH--LASTYLSH-----QEKLLLEGEKY-LQSKED----LR 2155
+ VQ ++ + H LAS + ++++L GE+ L + D L+
Sbjct: 1446 KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1505
Query: 2156 LMLIELKKKQEAGFALQHGLQEKKAQL-KIYKKFLKKAQDLTSL--------LKELKSQG 2206
+ + +KK Q LQ +Q + ++ I+++ D +SL L +LK
Sbjct: 1506 TVQLLIKKNQ----TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLW 1561
Query: 2207 NYLLECTKN----------------PSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVRE 2250
L+E T+ + E W+ + L+ ++ +D Q+ +++
Sbjct: 1562 GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE-QSAVSMLKK 1620
Query: 2251 HDSYQVCVTDLNTTLDNFSK-------------EFVSFSDKPVDQI------AVEEKLQK 2291
H + V D T+ SK E +S VD++ EE+ K
Sbjct: 1621 HQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGK 1680
Query: 2292 LQELEN--RLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA 2349
L E +L+ + L++ +A + V + +GQ + + LQ + ++ +
Sbjct: 1681 LDERHRLFQLNREVDDLEQWIA-EREVVAGSHELGQDY--EHVTMLQERFREFARDTGNI 1737
Query: 2350 KQEMECCLNSILKSKRSTEKKGKFTLPGRE---KQATSDVQE----STQESAAVEKLEED 2402
QE +N + ++ T+ + +A +D+ E TQ AA +L +
Sbjct: 1738 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1797
Query: 2403 WEINKD----------SAVEMAMSKQLSLNAQESMKNTEDE------RKVNELQNQPLEL 2446
+ K+ E Q ++ + M T + +V +LQ L
Sbjct: 1798 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1857
Query: 2447 DTMLRNEQLEEIEKLYTQ-LEAKKAAIKPLEQTEC-LNKTETGALVLHNIGYSAQHLDNL 2504
++ ++I+K + LEA K+ + E L T + ++++
Sbjct: 1858 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1917
Query: 2505 LQALITLKKNKE--SQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIK- 2561
++ + +K ++ S ++ + Q A +++ + T E K ++IK
Sbjct: 1918 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1977
Query: 2562 KFIASIEKEKDSLGNLKIKWE----NLSNHVTDMDKKLLESQI---------KQLEHGWE 2608
K + EK K+ + + +WE L H D + E+ + +++ +
Sbjct: 1978 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2037
Query: 2609 QVEQQIQK--KYSQQVVEYDE-FTTL--MNKVQDTEISLQQQQQHLQLRLKSPE------ 2657
+VE+ I++ + + +DE F+ L + ++ E+ QQ+++ + R SPE
Sbjct: 2038 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2097
Query: 2658 ERAGNQSMIALTTDLQATKHGFSVLKGQAELQMK 2691
E A +Q + Q +++G +G + +
Sbjct: 2098 EEAESQQQWDTSKGEQVSQNGLPAEQGSPRVSYR 2131
Score = 47.0 bits (110), Expect = 7e-04
Identities = 124/633 (19%), Positives = 254/633 (40%), Gaps = 104/633 (16%)
Query: 3566 KLLQKVQKNKEL--VQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDH--PEK---- 3617
K+L K+L V + + +F E+ F+Q ++M ++H EK
Sbjct: 646 KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRER 705
Query: 3618 ----SEQFEELQ--SILKKGKLTFENIMEKLRIKYSE----MYTIVPAEIESQV------ 3661
EQ+ L+ S ++K +L +++ + + + M I+ S V
Sbjct: 706 IIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYS 765
Query: 3662 -EECRKALEDIDEKISN-----EVLKSSPSYAMRRKIE--EINNGLHNVEKMLQQKSKNI 3713
+ K +D+ E+I+N + L S + E ++ L +E ++ K +
Sbjct: 766 TQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIE----ERYKEV 821
Query: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIP--FQQYQQVSQ 3771
+ ++K+ + + +E D+ I E++ +W++N+ IP + + +
Sbjct: 822 AELTRLRKQALQDTLALYKMFSEADACELWIDEKE-----QWLNNMQIPEKLEDLEVIQH 876
Query: 3772 RAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSHHASTVQM 3829
R E ++N ++ + + + + ++ H A D L T +
Sbjct: 877 RFESLEPEMNNQASRVAVVNQIARQ----LMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 932
Query: 3830 ALEDSEQKHNLLHSIFMDL-EDLSIIFETDELTQSIQELSNQ---VTALQQKIMESLPQI 3885
+D+ + + ++ E S I E ++ +S Q+L N V ALQ+K+
Sbjct: 933 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG----- 987
Query: 3886 QRMADDVVAIESEVKSMEKRVSKIKT-------ILLSK--EIFDFSPE--EHLKHGEVIL 3934
M D+VAIE+++ ++K K+++ +LS+ EI D E LK+ E L
Sbjct: 988 --MERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1045
Query: 3935 ENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVV 3994
+++ + ++ +Q L QT + + N L + KLL TQ +N +
Sbjct: 1046 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLL---TQHEN-----I 1094
Query: 3995 IKQTNEWDEEIENLKQILNNYS-AQFSLEHMSPDQ-ADKLPQLQGEIERM---EKQILSL 4049
+ + ++E+ + ++ + + Q ++M Q L E+ +M + +LS
Sbjct: 1095 KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQ 1154
Query: 4050 NQRKEDLLVDLKATVLNL--------HQHLKQEQEGVERDRLPAVTSEEGGVAERDASER 4101
+ + L D K L H + EG E A+ +E + DA+E
Sbjct: 1155 SHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAE----AAIKKQEDFMTTMDANEE 1210
Query: 4102 KLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
K+N + + V + ++ SD EK +
Sbjct: 1211 KIN-----AVVETGRRLVSDGNINSDRIQEKVD 1238
Score = 42.4 bits (98), Expect = 0.016
Identities = 131/696 (18%), Positives = 255/696 (36%), Gaps = 143/696 (20%)
Query: 4661 NEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMW 4720
++I + L + + + E+++ + E E L L + K D +DS
Sbjct: 1388 SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKR 1447
Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMV---------ELVKIGKE-----KLAHGHLKQT 4766
++ ++ EL P + E + + L + E++ +G+ HGH QT
Sbjct: 1448 LTVQTKFMELLEP-LNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQT 1506
Query: 4767 -----KSKVALQAQIENHK-----VF--FQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
K LQ +I+ H+ +F Q +V D + SA+ + L + + W
Sbjct: 1507 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDS---SSLSAEAIRQRLADLKQLWGL 1563
Query: 4815 QVTEV----KILEEKSRQCGMKLQSL-LQKWEEFDENYASLE---KDLEILISTLPSVSL 4866
+ E + LEE R + + W E Y E KD + +S L +
Sbjct: 1564 LIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQI 1623
Query: 4867 VEETEERLVERISFYQQIKRNIGG----KHARLYQTLNEGKQLVASVSCPELEGQIAKLE 4922
+E+ E E + + R + + R+ ++ +L A + E + KL+
Sbjct: 1624 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK-DLAEERRGKLD 1682
Query: 4923 EQW--LSLNKKID---------------HEL----HRLQALLKHLLSYNRDS-------- 4953
E+ LN+++D HEL + L + + RD+
Sbjct: 1683 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1742
Query: 4954 -------DQLTKWLESSQHTLNYWKEQSLNVSQDL----DTIRS------NINNFFEFSK 4996
D+L S T+ WK+ DL DT ++ F+ +K
Sbjct: 1743 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1802
Query: 4997 EV----------------DEKSSLKTA----------VISIGNQLLHLKETDTATLRASL 5030
E+ ++++++T + ++G Q+ L+E D A L+A+
Sbjct: 1803 EIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE-DAARLQAAY 1861
Query: 5031 A------------QFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQ 5078
A + + W L+ + +L +K + +++ WM +V Q
Sbjct: 1862 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG-DKFRFFSMVRDLMLWMEDVIRQ 1920
Query: 5079 TSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL---LQLSTCDVESKRY 5135
++ P S V+ L+ H+ + E+D + N S ++L + K Y
Sbjct: 1921 IEAQEK---PRDVSSVELLMNNHQGIKAEIDAR-------NDSFTTCIELGKSLLARKHY 1970
Query: 5136 ERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKT 5195
E E L ++ + + + + L +LE + + + WL QE L +
Sbjct: 1971 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEPYLSS 2029
Query: 5196 LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQ 5231
+ +SV V+KL+ + E A + L++
Sbjct: 2030 REIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2065
Score = 42.0 bits (97), Expect = 0.021
Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 10/209 (4%)
Query: 6562 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 6621
+ ++ H +L+ QQ D + W+ +E EL M+ K + + + +K+ Q
Sbjct: 1567 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1623
Query: 6622 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 6679
+ +A + Y V ++ +S+ + PES + R ++ L+ + + RG L
Sbjct: 1624 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1683
Query: 6680 RQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVER 6739
R L Q ++ +L W+A + + L E RE + +
Sbjct: 1684 RHRLFQ---LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI--G 1738
Query: 6740 QPQVDMLQEISNSLLIKGHGEDCIEAEEK 6768
Q +VD + +++ L+ GH + AE K
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWK 1767
Score = 40.8 bits (94), Expect = 0.047
Identities = 45/234 (19%), Positives = 104/234 (44%), Gaps = 22/234 (9%)
Query: 6527 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 6584
KEG ++++ P+ E A + E+ +G WE++++ Q +L + +
Sbjct: 1322 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1377
Query: 6585 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 6644
+ WL E++++ K D+ + + +K+ Q + + K + + S + L
Sbjct: 1378 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQMLENQMEVRKKEIEELQ-SQAQAL 1433
Query: 6645 QTESPESTELQS-RLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNL---LLWL 6700
E + E+ S RL + E + + + +L+ ++ HQ ++++ +LW+
Sbjct: 1434 SQEGKSTDEVDSKRLTVQTKFMELLEPLNER-----KHNLLASKEIHQFNRDVEDEILWV 1488
Query: 6701 ASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6754
R A TD + + + ++ L+KE+ QP++D + E S +++
Sbjct: 1489 GE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1539
Score = 38.9 bits (89), Expect = 0.18
Identities = 97/509 (19%), Positives = 202/509 (39%), Gaps = 38/509 (7%)
Query: 4643 KRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESR--VAKLRDEGERLH 4700
+ LY + Q +++ + + EQ + A TV + SR VA E ER+
Sbjct: 1598 QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERIS 1657
Query: 4701 LPYALLQEVYK-LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVEL-VKIGKEKL 4758
+ + + ++Y L+D+ + G L R+ F + D L Q + E V G +L
Sbjct: 1658 MRQSKVDKLYAGLKDLAEERRGKLDERHRL----FQLNREVDDLEQWIAEREVVAGSHEL 1713
Query: 4759 AHGHLKQTKSKVALQ------AQIENHKVFFQKLVADMLLIQAYS-AKILPSLLQNRETF 4811
+ T + + I +V +AD L+ +S A +
Sbjct: 1714 GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEA 1773
Query: 4812 WAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETE 4871
WA+ + ++++ +++ + L + + + E + ++ + L L ET
Sbjct: 1774 WADLL---ELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETL 1829
Query: 4872 ERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKK 4931
+R+ +F I+ +G + +L + + A +++ + ++ E W SL
Sbjct: 1830 QRM--HTTFEHDIQA-LGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDA 1886
Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNF 4991
+ RL ++ D L W+E + ++ +D+ ++ +NN
Sbjct: 1887 CESRRVRLVDTGDKFRFFSMVRD-LMLWMEDVIRQI-----EAQEKPRDVSSVELLMNNH 1940
Query: 4992 FEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
E+D ++ T I +G LL K + ++ L Q +K +I + D E L
Sbjct: 1941 QGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWL 2000
Query: 5052 HQ-LQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDY 5110
L++ + ++ E +W+ E S + S +V+ L+++H+ F E
Sbjct: 2001 RLILEVHQFSRDASVAE--AWLLGQEPYLSSRE---IGQSVDEVEKLIKRHEAF--EKSA 2053
Query: 5111 KQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
W F +L +L+T ++ R ++ E
Sbjct: 2054 ATWDERF--SALERLTTLELLEVRRQQEE 2080
Score = 35.8 bits (81), Expect = 1.5
Identities = 43/225 (19%), Positives = 91/225 (40%), Gaps = 14/225 (6%)
Query: 6563 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--Q 6620
A EL +LK ++LQ+ D ++ W+ E + A+ S + L K L Q
Sbjct: 1251 ASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQ 1304
Query: 6621 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 6680
+ + K + + + + + ++ +L L +WE + + L
Sbjct: 1305 AFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLF 1364
Query: 6681 QSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQ 6740
+ + + F Q +L WL +++ Q LL ++ LE ++ R+
Sbjct: 1365 DA-NKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL---KKQQMLENQMEVRK 1420
Query: 6741 PQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 6785
+++ LQ + +L +G D E + K ++ K +L E +++
Sbjct: 1421 KEIEELQSQAQALSQEGKSTD--EVDSKRLTVQTKFMELLEPLNE 1463
Score = 33.1 bits (74), Expect = 9.8
Identities = 58/281 (20%), Positives = 116/281 (41%), Gaps = 25/281 (8%)
Query: 6523 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 6580
+D KE ++ + +P Q L+ + E D WE ++ + + + + LQQ
Sbjct: 1000 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1055
Query: 6581 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 6640
D+ +WL +T+ + M P+ + E E + + + I D Y+ +
Sbjct: 1056 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1112
Query: 6641 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLM-QCQDFHQLSQNLLL 6698
+ Q ++ + L+ RL+ L W W RQ+L+ Q + Q ++
Sbjct: 1113 EMVTQGQTDAQYMFLRQRLQALDTGWNELH---KMWEN--RQNLLSQSHAYQQFLRDTKQ 1167
Query: 6699 WLASAKNRRQ-KAHVTDPKA--DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 6755
A N+ AH P A ++ + + M + + +++ + E L+
Sbjct: 1168 AEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFM---TTMDANEEKINAVVETGRRLVS 1224
Query: 6756 KGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 6795
G+ D I +EKV I+ + ++ RE S+ LM L+ ++
Sbjct: 1225 DGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1263
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 200 bits (508), Expect = 5e-50
Identities = 144/455 (31%), Positives = 225/455 (49%), Gaps = 80/455 (17%)
Query: 24 SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD- 82
+L E+E QKK FT W+NS LAR + I+DL+TD++ G +L+ LLEVLSG++LP+
Sbjct: 47 ALADEREAVQKKTFTKWVNSHLARVSCR--ITDLYTDLRDGRMLIKLLEVLSGERLPKPT 104
Query: 83 KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
KG C N++ AL FL+ + + L N+ DI+DGN + LGLIWTIIL F I+ ++
Sbjct: 105 KGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISV 164
Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
N + + SA+ ALLLW Q + A Y +VN
Sbjct: 165 ETEDN------------------------------KEKKSAKDALLLWCQMKTAGYPNVN 194
Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
+ +F +SWR+GMAF A+IH RPDLID +K + NL+ AF +AEQ L + +LL+PE
Sbjct: 195 IHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPE 254
Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDS-E 321
D+ V PDEKSI+TYV + Y M L ++ +++ K+L ++ E
Sbjct: 255 DISVDHPDEKSIITYVVTYYHYF---------------SKMKALAVEGKRIGKVLDNAIE 299
Query: 322 NDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAWDGLDHQINAWK 381
+ +KY SL S + + E+ L ++ + + G+ Q+ A+
Sbjct: 300 TEKMIEKYESLASDLLEWIEQTIIIL--------------NNRKFANSLVGVQQQLQAFN 345
Query: 382 IKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFK-----SLMDR 436
PP + +E L+ S + ++Q V + +E + +++
Sbjct: 346 TYRTVEKPPKFTEK----GNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEK 401
Query: 437 FEHHSNILLTFENKDENHLPLVPPNKLEEMKRRIN 471
EH + L E L+ KLE++ RR +
Sbjct: 402 AEHERELALRNE--------LIRQEKLEQLARRFD 428
Score = 99.0 bits (245), Expect = 1e-19
Identities = 303/1650 (18%), Positives = 640/1650 (38%), Gaps = 218/1650 (13%)
Query: 4817 TEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLE-------ILISTLPSVSLVEE 4869
+++K L + ++ G L + ++ E+ E Y SL DL I+++ + +
Sbjct: 278 SKMKALAVEGKRIGKVLDNAIET-EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 336
Query: 4870 TEERLVERISFYQQIKR-----NIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQ 4924
+++L + + Y+ +++ G L+ ++ + V P I+ + +
Sbjct: 337 VQQQL-QAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKA 395
Query: 4925 WLSLNKK-------IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNV 4977
W L K + +EL R + L + ++R + WL +Q ++ N
Sbjct: 396 WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS-----QDNF 450
Query: 4978 SQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
DL + + ++ AV+++ +L D + A + W
Sbjct: 451 GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLW 510
Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMI---SWMNNVEHQTSDEDSVHSPSSASQV 5094
L+ L +++L L +K EM+ WM+ ++ +D V
Sbjct: 511 EYLLELLRARRQRLEM----NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY---GKHLLGV 563
Query: 5095 KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRV 5154
+ LLQKH ++ + V VN S + +T K + + + M + +
Sbjct: 564 EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 623
Query: 5155 HGMLNRKIQHLEQ---LLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
+ + LE+ L + E + W+ +E+ L + + + SV +LL
Sbjct: 624 CQLAAERRARLEESRRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLLSK 679
Query: 5212 CQDIENQLAIKS----KALDELKQSYLTLESGAVPLLE------------DTASRIDELF 5255
+ E++++ +S +A+ E + G+ + E + S I +
Sbjct: 680 HRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKR 739
Query: 5256 QKRSSVLTQ----VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
+ +S+L Q + + M +L+ D +DE + ++ ++ K V +
Sbjct: 740 LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSL-----VKKHKDVAEEIA 794
Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQ 5371
R L +L ++A + + +V G+L G+ +R+ +V +
Sbjct: 795 NYR---PTLDTLHEQASALPQEHAESPDVRGRLSGI---------------EERYKEVAE 836
Query: 5372 AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQD 5431
+ Q Q L L+K +S A A L E K Q L N+ +P L+D
Sbjct: 837 LTRLRKQALQDTLALYKMFSEAD---ACELWIDE-KEQWLNNMQ---------IPEKLED 883
Query: 5432 IKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANE 5491
++ +QH + + +S + + Q A H P S + + L + ++
Sbjct: 884 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP----SEKEIKAQQDKLNTRWSQ 939
Query: 5492 FEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEK-----ENPDSFLNHVLALTAQSP 5546
F ++ + KD + S++ + E + ++ K ++ + L V+AL +
Sbjct: 940 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 999
Query: 5547 DIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWI 5606
+E + V+++ LSD+ K + + + L R +E+ + E+
Sbjct: 1000 GMER-DLVAIEAKLSDLQ-KEAEKLESEHPDQAQAILSRLAEISDVW---------EEMK 1048
Query: 5607 QLLEKIEEALKVDVANSLPELLEQQKTYK--MLEAEVSINQTIADSYVTQSLQLLDT--- 5661
L+ E +L A+ L + L ++ + + +I + +T++ +LL
Sbjct: 1049 TTLKNREASL--GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN 1106
Query: 5662 --TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT 5719
EI+N E ++ K+ D + QG Q L ++ Q T L + +
Sbjct: 1107 IKNEIDNYEE---DYQKMRDMGEMVTQG--QTDAQYMFLRQRLQALDTGWNELHKMWENR 1161
Query: 5720 SHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTD--LKTK 5777
+LLS ++F L T+ L N+E + T TLE E + + + T
Sbjct: 1162 QNLLSQSHAYQQF-LRDTKQAEAFLNNQE--YVLAHTEMPTTLEGAEAAIKKQEDFMTTM 1218
Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPL 5837
++ +I+ + ++ + + + Q V++ D +K +E S L +++ + L
Sbjct: 1219 DANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASEL-LMRLKDNRDL 1277
Query: 5838 PELHEDLH------NEKELIK------ELEQSLASWTQN---LKELQTMKADLTR----- 5877
+ +D NEK L E + W ++ + EL + K L +
Sbjct: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG 1337
Query: 5878 ----HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
E V+KE++ LH+ WE L + Q + D N +F + +L WL
Sbjct: 1338 MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWL 1396
Query: 5934 VQMENKVLQTADIS--IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA- 5990
+E+++ Q+ D + + L+K M E N K +++++ Q S + ++
Sbjct: 1397 HGLESQI-QSDDYGKDLTSVNILLKKQQMLE-NQMEVRKKEIEELQSQAQALSQEGKSTD 1454
Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA-RIESELSKPV 6049
E+D K + ++ L + + R L + I Q ++++ + W+ R+ S
Sbjct: 1455 EVDSKRLTVQTKFMELLEPLNERKHNLLASKE-IHQFNRDVEDEILWVGERMPLATSTDH 1513
Query: 6050 VYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
+++ Q +Q + + Q LQ++I+ H ++ +F ++ DS + + E +I+Q
Sbjct: 1514 GHNL---QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE----AIRQR 1566
Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
L + W + + +R ++EE R Q++ D + E W+ E ++
Sbjct: 1567 LADLKQLWGLLIEETEKRHRRLEEAHRA-QQYYFDAAEAEAWMSEQELYMMSEEKAKD-E 1624
Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTA-------------SRLK 6216
SA LK+ + ++ + + + ++K R L ++ ++ + LK
Sbjct: 1625 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK 1684
Query: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE 6276
+ E + D R L +L + E++ RE ++ E+ +V E
Sbjct: 1685 DLAEERRGKLDERHR-----LFQLNREVDDLEQWIAERE-VVAGSHELGQDYEHVTMLQE 1738
Query: 6277 SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQ------------------LIQKSEPLD 6318
+ N Q+ + + D+LI G L++ +
Sbjct: 1739 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1798
Query: 6319 AVLIED-ELEELHRYCQEVFGRVSRFHRRL 6347
+L EL + + +E+FGR+ H++L
Sbjct: 1799 QILAASYELHKFYHDAKEIFGRIQDKHKKL 1828
Score = 83.6 bits (205), Expect = 6e-15
Identities = 226/1304 (17%), Positives = 502/1304 (38%), Gaps = 152/1304 (11%)
Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
+K +ER E AEH E+ L ++ E+L + + K + WL +
Sbjct: 393 NKAWERLEKAEHEREL---------ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG------AVPLLE 5245
+ + +V+ + IE +A + + + LE+ + +
Sbjct: 444 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503
Query: 5246 DTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKP 5305
D R+ E + Q ++ +Q + QE DE+ ++ + ++ K
Sbjct: 504 DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLS----QDYGKH 559
Query: 5306 VVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKR 5365
++ + L+ + +AE G Q+ +G P ++I ++ +
Sbjct: 560 LLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFC 619
Query: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
+ ++ Q A++ + + +LWK + E ++++E ++ + G +L ++
Sbjct: 620 YQELCQLAAERRARLEESRRLWKFFWEM-AEEEGWIREKE----KILSSDDYGKDLTSVM 674
Query: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKML 5485
L + + ++ F Q + + + + ++ ++ A LE++
Sbjct: 675 R-LLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLS 733
Query: 5486 LVKANEFE--FVLSQFK----DFGVRLESLKGLIM-----HEEENLDRLHQQEKENPDSF 5534
++ E +L QF+ D + + ++ H+E + L ++ K+ +
Sbjct: 734 AIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI 793
Query: 5535 LNH-----VLALTAQSPDIEHLNEVSLKLPLSDVA-----VKTLQNMNRQWIRATATALE 5584
N+ L A + EH ++ LS + V L + +Q ++ T +
Sbjct: 794 ANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYK 853
Query: 5585 RCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
SE CE WI EK + + + L +L Q ++ LE E++ N
Sbjct: 854 MFSEADA----------CELWID--EKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMN-N 900
Query: 5645 QTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQD 5704
Q + V Q + L + + E + KL RW + V ++K D L+
Sbjct: 901 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKK---DALLS---- 953
Query: 5705 FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEA 5764
S++N +T + ++ + T+ L ++L + QR+ T L A
Sbjct: 954 -ALSIQNYHLECNETKSWIR----EKTKVIESTQDLGNDLAGV-MALQRKLTGMERDLVA 1007
Query: 5765 GEKLLLTTDLKTK------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETW 5812
E L +DL+ + +++ R++++ D W++M+ L K ++++
Sbjct: 1008 IEAKL--SDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTL----KNREASLGEA 1061
Query: 5813 DQCEKKIKELK------SRLQVLKAQSEDP--------LPELHEDLHNEKELIKELEQSL 5858
+ ++ +++L SR Q A + P L HE++ NE + +E Q +
Sbjct: 1062 SKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM 1121
Query: 5859 ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
+ + + QT D L + + L LH+ WE+ +Q + + +
Sbjct: 1122 RDMGEMVTQGQT---DAQYMFLRQRLQALDTGWNELHKMWEN--------RQNLLSQSHA 1170
Query: 5919 WVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE---KLQKDCMEEINLFSENKLQLKQ 5975
+ F K+ A+L E + T + E E K Q+D M ++ E + +
Sbjct: 1171 YQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVE 1230
Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
G +L+ N + + I +K++ I+DR + + + +LK+ +Q+ ++ L
Sbjct: 1231 TGRRLVSDGNIN-SDRIQEKVDSIDDRHRKNRETASELLMRLKDN-RDLQKFLQDCQELS 1288
Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
W+ + ++ + YD + + + + + Q ++ + ++ + L+ +
Sbjct: 1289 LWINE-KMLTAQDMSYD--EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKP 1345
Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
ETE +++ L + W + + + + ++ + + + F + + WL
Sbjct: 1346 ----ETEA-VVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGL 1399
Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAREN-------- 6207
E + + L TS LK+ + + Q+ R ++E + Q + L++E
Sbjct: 1400 ESQIQSDDYGKDL-TSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1458
Query: 6208 -RTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDL 6266
R ++ +++ N+R NL + + +F E ++W+ E
Sbjct: 1459 KRLTVQTKFMELLEPLNERKHNLLA------------SKEIHQFNRDVEDEILWVGERMP 1506
Query: 6267 QLTNVEHFSESDADDKMRQLNG-FQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDE 6325
T+ +H + + N Q+EI + +ID + + ++ S L A I
Sbjct: 1507 LATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQR 1566
Query: 6326 LEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED 6369
L +L + + + HRRL + +A+E E M +
Sbjct: 1567 LADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1610
Score = 78.2 bits (191), Expect = 3e-13
Identities = 173/872 (19%), Positives = 347/872 (39%), Gaps = 156/872 (17%)
Query: 4657 QQSLNEISGQSVAEQLQ----KADAYTVELENAESRVAKLRDEGERL-HLPYALLQEVYK 4711
+Q LN + E L+ + ++ E+ N SRVA + +L H + +E+
Sbjct: 869 EQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 928
Query: 4712 LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMV----------------ELVKI-- 4753
+D L++ W R + + ++DALL + E K+
Sbjct: 929 QQDKLNTRWSQFRE---------LVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979
Query: 4754 ----------GKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPS 4803
G L + VA++A++ + + +KL ++ A+ + S
Sbjct: 980 STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE----HPDQAQAILS 1035
Query: 4804 LLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPS 4863
L W E T +K E + KLQ L+ ++F S + I++
Sbjct: 1036 RLAEISDVWEEMKTTLKNREASLGEAS-KLQQFLRDLDDFQ----SWLSRTQTAIASEDM 1090
Query: 4864 VSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEE 4923
+ + E E+ L + ++ IK I + YQ + + ++V +GQ +
Sbjct: 1091 PNTLTEAEKLLTQ----HENIKNEIDN-YEEDYQKMRDMGEMVT-------QGQT---DA 1135
Query: 4924 QWLSLNKKID------HELHRLQALLKHLLSYN-------RDSDQLTKWLESSQHTLNYW 4970
Q++ L +++ +ELH++ ++LLS + RD+ Q +L + ++ L +
Sbjct: 1136 QYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHT 1195
Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
+ + L+ + I +F +D AV+ G +L+ ++ ++ +
Sbjct: 1196 E-----MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
Query: 5031 AQFEQKWT----------MLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080
+ + M + D+Q+ L Q E+ W+N E +
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-----------ELSLWIN--EKMLT 1297
Query: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEM-DYKQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
+D + + K L KH+ F E+ K+W+ D + + +QL + K
Sbjct: 1298 AQDMSYDEARNLHSKWL--KHQAFMAELASNKEWL-DKIEKEGMQL----ISEKPETEAV 1350
Query: 5140 FAEHLGEMNRQWHRVHGMLNRKIQHL--EQLLESITESENKIQILNNWLEAQEERLKTLQ 5197
E L +++ W + K Q L E T+S L+ WL E ++++
Sbjct: 1351 VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQS---CADLDKWLHGLESQIQSDD 1407
Query: 5198 KPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
+ + SV LL Q +ENQ+ ++ K ++EL+ L DE+ K
Sbjct: 1408 YGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ--------AQALSQEGKSTDEVDSK 1459
Query: 5258 RSSVLTQ-------VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSL 5310
R +V T+ +N+ K ++ + + + + DE+ + R + S +L
Sbjct: 1460 RLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERM--PLATSTDHGHNL 1517
Query: 5311 ETLRCQVENLQSLQDEAESS----EGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
+T++ ++ Q+LQ E + + +E+ Q ++ L AE I ++ + + W
Sbjct: 1518 QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS---AEAIRQRLADLKQLW 1574
Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQE--------AKFQQLANISMSG 5418
+ + + ++ + + + Y +A EA A + +QE AK +Q A +SM
Sbjct: 1575 GLLIEETEKRHRRLEEAHRAQQYYFDA-AEAEAWMSEQELYMMSEEKAKDEQSA-VSMLK 1632
Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNS 5450
+ +IL A++D E H + KT A + +S
Sbjct: 1633 KH--QILEQAVEDYAETVHQLSKTSRALVADS 1662
Score = 77.8 bits (190), Expect = 3e-13
Identities = 265/1440 (18%), Positives = 537/1440 (37%), Gaps = 197/1440 (13%)
Query: 4959 WLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL 5018
W+ + L+ S + +DL ++ ++ F E+ +S I G ++
Sbjct: 653 WIREKEKILS-----SDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE 707
Query: 5019 KETDTATLRASLAQFEQKWTMLITQLPDIQEK-------LHQLQMEKLPSRKAITEMISW 5071
+ + +R + ++W L QL I++K LHQ Q + ++ +W
Sbjct: 708 EHFGSEKIRERIIYIREQWANL-EQLSAIRKKRLEEASLLHQFQADA-------DDIDAW 759
Query: 5072 MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE 5131
M ++ S D H S L++KHK+ E+ + +D +++ L E
Sbjct: 760 MLDILKIVSSSDVGHDEYSTQS---LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE 816
Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
S + L + ++ V + + Q L+ L ++ + ++ W++ +E+
Sbjct: 817 SP-----DVRGRLSGIEERYKEVAELTRLRKQALQDTL-ALYKMFSEADACELWIDEKEQ 870
Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRI 5251
L +Q PE + ++ + + +E ++ ++ + + Q L P ++ ++
Sbjct: 871 WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 930
Query: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
D+L + S V++ K ++ S L + Y +E +E ++ + L
Sbjct: 931 DKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLA 989
Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQV-- 5369
+ L ++ + + E LQ+ KL+ P A+ I + W ++
Sbjct: 990 GVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKT 1049
Query: 5370 ----NQAIADQLQKAQSLL------QLWKAYS----------NAHGEAAARLKQQE---- 5405
+A + K Q L Q W + + N EA L Q E
Sbjct: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
Query: 5406 ---------AKFQQLANISMSGNNLAE--ILPPALQDI----KELQHDVQKTKEAFLQNS 5450
K + + + G A+ L LQ + EL H + + ++ L S
Sbjct: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWENRQNLLSQS 1168
Query: 5451 SVLDRLPQPAESS-----------THMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
+ + + + H +P L + A ++ + + E ++
Sbjct: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAV 1228
Query: 5500 KDFGVRLESLKGL----IMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS 5555
+ G RL S + I + +++D H++ +E L + ++ E+S
Sbjct: 1229 VETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELS 1288
Query: 5556 L-----KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLE 5610
L L D++ +N++ +W++ A E S ++W+ +E
Sbjct: 1289 LWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASN--------------KEWLDKIE 1334
Query: 5611 KIEEALKVDVANSLPELLEQQK---TYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENR 5667
K E +++ E + ++K +KM E S QT A +L D N+
Sbjct: 1335 K--EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ-------RLFDA----NK 1381
Query: 5668 PEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
E T+ D+W + ++ Q + D G +D TSV L + + + K
Sbjct: 1382 AELFTQSCADLDKWLHGLES--QIQSDDYG-----KDL-TSVNILLKKQQMLENQMEVRK 1433
Query: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQL 5787
+ Q ++L E K+ + +R T +E E L + K + I Q
Sbjct: 1434 KEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL---NERKHNLLASKEIHQF 1490
Query: 5788 QDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNE 5847
+D + E + ST + + ++ L + Q L+ + + P + +
Sbjct: 1491 NRDVEDEILWVGERMPLATSTDHGHNL--QTVQLLIKKNQTLQKEIQGHQPRIDDIFERS 1548
Query: 5848 KELIKELEQ-SLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
+ ++ + S + Q L +L+ + +L E+ E HR+ E+ A
Sbjct: 1549 QNIVTDSSSLSAEAIRQRLADLKQLWG------------LLIEETEKRHRRLEE-----A 1591
Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEE-MIEKLQKDCMEE--I 5963
R Q+ F+ E AW+ + E ++ E+ + L+K + E +
Sbjct: 1592 HRAQQ--------YYFDAAEAE--AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAV 1641
Query: 5964 NLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAF 6023
++E QL + L+ A + + I + +K++ + L D+ R KL E
Sbjct: 1642 EDYAETVHQLSKTSRALV-ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1700
Query: 6024 IQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQ-QDLQRDIEQHSAGVES 6082
QL++ + +L W+A E +++ D E L E+ ++ RD + G E
Sbjct: 1701 F-QLNREVDDLEQWIAEREVVAGS---HELGQDYEHVTMLQERFREFARD--TGNIGQER 1754
Query: 6083 VFNICDVLLHDSDACANETECD--SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQK 6140
V D + H +D N D +I + L+ W ++ + R + ++ L K
Sbjct: 1755 V----DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL-HK 1809
Query: 6141 FLDD----YSRFED-WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLEL 6195
F D + R +D K E N+ E L + F+ I TQ+
Sbjct: 1810 FYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ-------RMHTTFEHDIQALGTQVRQ 1862
Query: 6196 INKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHF-TNQREEFEGTR 6254
+ + RL D A +++ +E + W +L + RR+R T + F
Sbjct: 1863 LQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACES--RRVRLVDTGDKFRFFSMV 1920
Query: 6255 ESILVWLTEMDLQLTNVEHFSE-SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
+++W+ ++ Q+ E + S + M G + EI + I G+ L+ +
Sbjct: 1921 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980
Score = 48.9 bits (115), Expect = 2e-04
Identities = 177/879 (20%), Positives = 349/879 (39%), Gaps = 166/879 (18%)
Query: 2949 HEKTSAL-QEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
HE+ SAL QE A+S L G+ EE Y LT ++ LQ D
Sbjct: 804 HEQASALPQEHAESPDVRGRL------SGI-EERYKEVAELTRLRKQALQ--------DT 848
Query: 3008 IGLNWDFSQLDQLQTQVFEKEK-----ELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQI 3062
+ L FS+ D + + EKE+ ++ EK++ L+ + ++++L +M ++
Sbjct: 849 LALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQH---RFESLEPEMNNQASRV 905
Query: 3063 KKMTEVVLKAPDSS-PESRRLNAQI--LSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKE 3119
+ ++ + S P + + AQ L+ R + + L D KK E
Sbjct: 906 AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR--KKDALLSALSIQNYHLE 963
Query: 3120 ILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLIN 3179
+ K E K+ + Q++ +L+ ++ +E L + S LQ+
Sbjct: 964 CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG-MERDLVAIEAKLSDLQKEAE-K 1021
Query: 3180 LEIKHIQNEKDNCEAFQE--QVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQ 3237
LE +H + E VW EM + K RE + EAS ++ LR+ +D Q
Sbjct: 1022 LESEHPDQAQAILSRLAEISDVWEEMKTTL------KNREASLGEASKLQQFLRDLDDFQ 1075
Query: 3238 MQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPL 3297
L+ + +T + ++ N +T A + +T E I + ++ N EE + +
Sbjct: 1076 SWLSRT---QTAIASEDMPN------TLTEAEKLLTQHENI----KNEIDNYEEDYQ-KM 1121
Query: 3298 RKQEELES---TVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEA 3354
R E+ + T A L ++L + + +L + ++ + S + F +A
Sbjct: 1122 RDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQA 1181
Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQS---MSSLPLSYREALERLEQSKALVS--- 3408
E +L N + Y ++ T L E + + M+++ + + +E + LVS
Sbjct: 1182 EAFLNNQE-YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN 1240
Query: 3409 -------------------NLISTKEELMKLR--QILRLLRLRCTENDGICLLKIVSA-- 3445
N + E LM+L+ + L+ C E K+++A
Sbjct: 1241 INSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQD 1300
Query: 3446 --------LWEKWLS----LLEAAKEWEMWCEELKQE-WKFVSEEIEREAII------LD 3486
L KWL + E A E W +++++E + +SE+ E EA++ L
Sbjct: 1301 MSYDEARNLHSKWLKHQAFMAELASNKE-WLDKIEKEGMQLISEKPETEAVVKEKLTGLH 1359
Query: 3487 NLQEELPEISKTK-EAATTEELSELLDCLC-----------------QYGEN-------V 3521
+ E L ++TK + +EL C YG++ +
Sbjct: 1360 KMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL 1419
Query: 3522 EKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTE 3581
+KQQ+L + R + I+ + + A+ QE S E +K L K EL++
Sbjct: 1420 KKQQMLENQMEVRKKEIEELQSQAQALS-----QEGKSTDEVDSKRLTVQTKFMELLEPL 1474
Query: 3582 IQERHSF--TKEIIAL-KNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
+ +H+ +KEI ++ + + M + + +Q ++KK +
Sbjct: 1475 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQ------ 1528
Query: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSS--PSYAMRRKIEEIN 3696
++ +++ + ++DI E+ N V SS + A+R+++ ++
Sbjct: 1529 -----------------TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLK 1571
Query: 3697 NGLHNVEKMLQQKSKNIEKAQEIQKKMWD--ELDLWHSK 3733
+ + +++ + +E+A Q+ +D E + W S+
Sbjct: 1572 QLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1610
Score = 47.4 bits (111), Expect = 5e-04
Identities = 253/1411 (17%), Positives = 539/1411 (38%), Gaps = 231/1411 (16%)
Query: 1464 KHRKKSLIRLDKVLDE----YEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENT 1519
++ +SL++ K + E Y L E A++LP + V + ++
Sbjct: 776 EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEERYKEV 834
Query: 1520 KALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEI 1579
L + L L K + + + +KE+ + ++Q E+L+ E
Sbjct: 835 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEK-LEDLEVIQHRFES 893
Query: 1580 VKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD----RWLDINEKTE 1635
++ E N V +NQ+ + L P EKE D RW E +
Sbjct: 894 LEPEMNNQASRVAVVNQIARQLMH--------SGHPSEKEIKAQQDKLNTRWSQFRELVD 945
Query: 1636 DYYENLGRALALWDKLFNLK-NVIDEWTEKALQKMELHQLTEEDRER----------LKE 1684
+ L AL++ + ++L+ N W + + +E Q D ++
Sbjct: 946 RKKDALLSALSIQN--YHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 1003
Query: 1685 ELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALS 1744
+L E K S+ + +++ SE P + Q + S + + ++ T N A
Sbjct: 1004 DLVAIEAKLSDLQKEAEKLE-----SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1058
Query: 1745 GSTAELRE---DLDQAKTQIGMTESLLKALSPSDSL----EIFTKLEEIQQQI------L 1791
G ++L++ DLD ++ + T++ + + ++L ++ T+ E I+ +I
Sbjct: 1059 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY 1118
Query: 1792 QQKHSM-------------ILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
Q+ M + L ++ L +EL K +E+ +L + Q H +
Sbjct: 1119 QKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLS------QSHAYQ 1172
Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
K + +N + L E T + E ++K DF+T N + ++++V+
Sbjct: 1173 QFLRDTKQAEAFLNNQEYVLAHT-EMPTTLEGAEAAIKKQEDFMTTMDANEE--KINAVV 1229
Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
+ ++ + ++ + EK++SI K E + + L+RL+ D+R+L+K+
Sbjct: 1230 ETGRRLVSDGNINS--------DRIQEKVDSIDDRHRKNRETASELLMRLK-DNRDLQKF 1280
Query: 1959 LTNQEE------------------KWKGMEEPGEKTELFCQALARKREQFESVAQLNNSL 2000
L + +E + + + K + F LA +E + + + L
Sbjct: 1281 LQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQL 1340
Query: 2001 KEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
E E ++ E + + +L ++ + + + + F D+ W+ +
Sbjct: 1341 ISEK-PETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGL 1399
Query: 2061 KE------------SLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE-SS 2107
+ S+ +L + + + ++K KEI L+ + A + E S
Sbjct: 1400 ESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRK-KEIEELQSQAQALSQEGKSTDEVDS 1458
Query: 2108 EAPLVQKTLTDISNQWDNTLH--LASTYLSH-----QEKLLLEGEKY-LQSKED----LR 2155
+ VQ ++ + H LAS + ++++L GE+ L + D L+
Sbjct: 1459 KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1518
Query: 2156 LMLIELKKKQEAGFALQHGLQEKKAQL-KIYKKFLKKAQDLTSL--------LKELKSQG 2206
+ + +KK Q LQ +Q + ++ I+++ D +SL L +LK
Sbjct: 1519 TVQLLIKKNQ----TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLW 1574
Query: 2207 NYLLECTKN----------------PSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVRE 2250
L+E T+ + E W+ + L+ ++ +D Q+ +++
Sbjct: 1575 GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE-QSAVSMLKK 1633
Query: 2251 HDSYQVCVTDLNTTLDNFSK-------------EFVSFSDKPVDQI------AVEEKLQK 2291
H + V D T+ SK E +S VD++ EE+ K
Sbjct: 1634 HQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGK 1693
Query: 2292 LQELEN--RLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA 2349
L E +L+ + L++ +A + V + +GQ + + LQ + ++ +
Sbjct: 1694 LDERHRLFQLNREVDDLEQWIA-EREVVAGSHELGQDY--EHVTMLQERFREFARDTGNI 1750
Query: 2350 KQEMECCLNSILKSKRSTEKKGKFTLPGRE---KQATSDVQE----STQESAAVEKLEED 2402
QE +N + ++ T+ + +A +D+ E TQ AA +L +
Sbjct: 1751 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1810
Query: 2403 WEINKD----------SAVEMAMSKQLSLNAQESMKNTEDE------RKVNELQNQPLEL 2446
+ K+ E Q ++ + M T + +V +LQ L
Sbjct: 1811 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1870
Query: 2447 DTMLRNEQLEEIEKLYTQ-LEAKKAAIKPLEQTEC-LNKTETGALVLHNIGYSAQHLDNL 2504
++ ++I+K + LEA K+ + E L T + ++++
Sbjct: 1871 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1930
Query: 2505 LQALITLKKNKE--SQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIK- 2561
++ + +K ++ S ++ + Q A +++ + T E K ++IK
Sbjct: 1931 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1990
Query: 2562 KFIASIEKEKDSLGNLKIKWE----NLSNHVTDMDKKLLESQI---------KQLEHGWE 2608
K + EK K+ + + +WE L H D + E+ + +++ +
Sbjct: 1991 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2050
Query: 2609 QVEQQIQK--KYSQQVVEYDE-FTTL--MNKVQDTEISLQQQQQHLQLRLKSPE------ 2657
+VE+ I++ + + +DE F+ L + ++ E+ QQ+++ + R SPE
Sbjct: 2051 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2110
Query: 2658 ERAGNQSMIALTTDLQATKHGFSVLKGQAEL 2688
E A +Q + Q +++G +G +
Sbjct: 2111 EEAESQQQWDTSKGEQVSQNGLPAEQGSPRM 2141
Score = 47.0 bits (110), Expect = 7e-04
Identities = 124/633 (19%), Positives = 254/633 (40%), Gaps = 104/633 (16%)
Query: 3566 KLLQKVQKNKEL--VQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDH--PEK---- 3617
K+L K+L V + + +F E+ F+Q ++M ++H EK
Sbjct: 659 KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRER 718
Query: 3618 ----SEQFEELQ--SILKKGKLTFENIMEKLRIKYSE----MYTIVPAEIESQV------ 3661
EQ+ L+ S ++K +L +++ + + + M I+ S V
Sbjct: 719 IIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYS 778
Query: 3662 -EECRKALEDIDEKISN-----EVLKSSPSYAMRRKIE--EINNGLHNVEKMLQQKSKNI 3713
+ K +D+ E+I+N + L S + E ++ L +E ++ K +
Sbjct: 779 TQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIE----ERYKEV 834
Query: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIP--FQQYQQVSQ 3771
+ ++K+ + + +E D+ I E++ +W++N+ IP + + +
Sbjct: 835 AELTRLRKQALQDTLALYKMFSEADACELWIDEKE-----QWLNNMQIPEKLEDLEVIQH 889
Query: 3772 RAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSHHASTVQM 3829
R E ++N ++ + + + + ++ H A D L T +
Sbjct: 890 RFESLEPEMNNQASRVAVVNQIARQ----LMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
Query: 3830 ALEDSEQKHNLLHSIFMDL-EDLSIIFETDELTQSIQELSNQ---VTALQQKIMESLPQI 3885
+D+ + + ++ E S I E ++ +S Q+L N V ALQ+K+
Sbjct: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG----- 1000
Query: 3886 QRMADDVVAIESEVKSMEKRVSKIKT-------ILLSK--EIFDFSPE--EHLKHGEVIL 3934
M D+VAIE+++ ++K K+++ +LS+ EI D E LK+ E L
Sbjct: 1001 --MERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1058
Query: 3935 ENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVV 3994
+++ + ++ +Q L QT + + N L + KLL TQ +N +
Sbjct: 1059 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLL---TQHEN-----I 1107
Query: 3995 IKQTNEWDEEIENLKQILNNYS-AQFSLEHMSPDQ-ADKLPQLQGEIERM---EKQILSL 4049
+ + ++E+ + ++ + + Q ++M Q L E+ +M + +LS
Sbjct: 1108 KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQ 1167
Query: 4050 NQRKEDLLVDLKATVLNL--------HQHLKQEQEGVERDRLPAVTSEEGGVAERDASER 4101
+ + L D K L H + EG E A+ +E + DA+E
Sbjct: 1168 SHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAE----AAIKKQEDFMTTMDANEE 1223
Query: 4102 KLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
K+N + + V + ++ SD EK +
Sbjct: 1224 KIN-----AVVETGRRLVSDGNINSDRIQEKVD 1251
Score = 42.4 bits (98), Expect = 0.016
Identities = 131/696 (18%), Positives = 255/696 (36%), Gaps = 143/696 (20%)
Query: 4661 NEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMW 4720
++I + L + + + E+++ + E E L L + K D +DS
Sbjct: 1401 SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKR 1460
Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMV---------ELVKIGKE-----KLAHGHLKQT 4766
++ ++ EL P + E + + L + E++ +G+ HGH QT
Sbjct: 1461 LTVQTKFMELLEP-LNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQT 1519
Query: 4767 -----KSKVALQAQIENHK-----VF--FQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
K LQ +I+ H+ +F Q +V D + SA+ + L + + W
Sbjct: 1520 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDS---SSLSAEAIRQRLADLKQLWGL 1576
Query: 4815 QVTEV----KILEEKSRQCGMKLQSL-LQKWEEFDENYASLE---KDLEILISTLPSVSL 4866
+ E + LEE R + + W E Y E KD + +S L +
Sbjct: 1577 LIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQI 1636
Query: 4867 VEETEERLVERISFYQQIKRNIGG----KHARLYQTLNEGKQLVASVSCPELEGQIAKLE 4922
+E+ E E + + R + + R+ ++ +L A + E + KL+
Sbjct: 1637 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK-DLAEERRGKLD 1695
Query: 4923 EQW--LSLNKKID---------------HEL----HRLQALLKHLLSYNRDS-------- 4953
E+ LN+++D HEL + L + + RD+
Sbjct: 1696 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1755
Query: 4954 -------DQLTKWLESSQHTLNYWKEQSLNVSQDL----DTIRS------NINNFFEFSK 4996
D+L S T+ WK+ DL DT ++ F+ +K
Sbjct: 1756 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1815
Query: 4997 EV----------------DEKSSLKTA----------VISIGNQLLHLKETDTATLRASL 5030
E+ ++++++T + ++G Q+ L+E D A L+A+
Sbjct: 1816 EIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE-DAARLQAAY 1874
Query: 5031 A------------QFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQ 5078
A + + W L+ + +L +K + +++ WM +V Q
Sbjct: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG-DKFRFFSMVRDLMLWMEDVIRQ 1933
Query: 5079 TSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL---LQLSTCDVESKRY 5135
++ P S V+ L+ H+ + E+D + N S ++L + K Y
Sbjct: 1934 IEAQEK---PRDVSSVELLMNNHQGIKAEIDAR-------NDSFTTCIELGKSLLARKHY 1983
Query: 5136 ERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKT 5195
E E L ++ + + + + L +LE + + + WL QE L +
Sbjct: 1984 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEPYLSS 2042
Query: 5196 LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQ 5231
+ +SV V+KL+ + E A + L++
Sbjct: 2043 REIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2078
Score = 42.0 bits (97), Expect = 0.021
Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 10/209 (4%)
Query: 6562 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 6621
+ ++ H +L+ QQ D + W+ +E EL M+ K + + + +K+ Q
Sbjct: 1580 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1636
Query: 6622 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 6679
+ +A + Y V ++ +S+ + PES + R ++ L+ + + RG L
Sbjct: 1637 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1696
Query: 6680 RQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVER 6739
R L Q ++ +L W+A + + L E RE + +
Sbjct: 1697 RHRLFQ---LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI--G 1751
Query: 6740 QPQVDMLQEISNSLLIKGHGEDCIEAEEK 6768
Q +VD + +++ L+ GH + AE K
Sbjct: 1752 QERVDTVNHLADELINSGHSDAATIAEWK 1780
Score = 40.8 bits (94), Expect = 0.047
Identities = 45/234 (19%), Positives = 104/234 (44%), Gaps = 22/234 (9%)
Query: 6527 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 6584
KEG ++++ P+ E A + E+ +G WE++++ Q +L + +
Sbjct: 1335 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
Query: 6585 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 6644
+ WL E++++ K D+ + + +K+ Q + + K + + S + L
Sbjct: 1391 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQMLENQMEVRKKEIEELQ-SQAQAL 1446
Query: 6645 QTESPESTELQS-RLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNL---LLWL 6700
E + E+ S RL + E + + + +L+ ++ HQ ++++ +LW+
Sbjct: 1447 SQEGKSTDEVDSKRLTVQTKFMELLEPLNER-----KHNLLASKEIHQFNRDVEDEILWV 1501
Query: 6701 ASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6754
R A TD + + + ++ L+KE+ QP++D + E S +++
Sbjct: 1502 GE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1552
Score = 38.9 bits (89), Expect = 0.18
Identities = 97/509 (19%), Positives = 202/509 (39%), Gaps = 38/509 (7%)
Query: 4643 KRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESR--VAKLRDEGERLH 4700
+ LY + Q +++ + + EQ + A TV + SR VA E ER+
Sbjct: 1611 QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERIS 1670
Query: 4701 LPYALLQEVYK-LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVEL-VKIGKEKL 4758
+ + + ++Y L+D+ + G L R+ F + D L Q + E V G +L
Sbjct: 1671 MRQSKVDKLYAGLKDLAEERRGKLDERHRL----FQLNREVDDLEQWIAEREVVAGSHEL 1726
Query: 4759 AHGHLKQTKSKVALQ------AQIENHKVFFQKLVADMLLIQAYS-AKILPSLLQNRETF 4811
+ T + + I +V +AD L+ +S A +
Sbjct: 1727 GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEA 1786
Query: 4812 WAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETE 4871
WA+ + ++++ +++ + L + + + E + ++ + L L ET
Sbjct: 1787 WADLL---ELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETL 1842
Query: 4872 ERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKK 4931
+R+ +F I+ +G + +L + + A +++ + ++ E W SL
Sbjct: 1843 QRM--HTTFEHDIQA-LGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDA 1899
Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNF 4991
+ RL ++ D L W+E + ++ +D+ ++ +NN
Sbjct: 1900 CESRRVRLVDTGDKFRFFSMVRD-LMLWMEDVIRQI-----EAQEKPRDVSSVELLMNNH 1953
Query: 4992 FEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
E+D ++ T I +G LL K + ++ L Q +K +I + D E L
Sbjct: 1954 QGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWL 2013
Query: 5052 HQ-LQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDY 5110
L++ + ++ E +W+ E S + S +V+ L+++H+ F E
Sbjct: 2014 RLILEVHQFSRDASVAE--AWLLGQEPYLSSRE---IGQSVDEVEKLIKRHEAF--EKSA 2066
Query: 5111 KQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
W F +L +L+T ++ R ++ E
Sbjct: 2067 ATWDERF--SALERLTTLELLEVRRQQEE 2093
Score = 35.8 bits (81), Expect = 1.5
Identities = 43/225 (19%), Positives = 91/225 (40%), Gaps = 14/225 (6%)
Query: 6563 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--Q 6620
A EL +LK ++LQ+ D ++ W+ E + A+ S + L K L Q
Sbjct: 1264 ASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQ 1317
Query: 6621 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 6680
+ + K + + + + + ++ +L L +WE + + L
Sbjct: 1318 AFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLF 1377
Query: 6681 QSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQ 6740
+ + + F Q +L WL +++ Q LL ++ LE ++ R+
Sbjct: 1378 DA-NKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL---KKQQMLENQMEVRK 1433
Query: 6741 PQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 6785
+++ LQ + +L +G D E + K ++ K +L E +++
Sbjct: 1434 KEIEELQSQAQALSQEGKSTD--EVDSKRLTVQTKFMELLEPLNE 1476
Score = 33.1 bits (74), Expect = 9.8
Identities = 58/281 (20%), Positives = 116/281 (41%), Gaps = 25/281 (8%)
Query: 6523 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 6580
+D KE ++ + +P Q L+ + E D WE ++ + + + + LQQ
Sbjct: 1013 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1068
Query: 6581 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 6640
D+ +WL +T+ + M P+ + E E + + + I D Y+ +
Sbjct: 1069 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1125
Query: 6641 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLM-QCQDFHQLSQNLLL 6698
+ Q ++ + L+ RL+ L W W RQ+L+ Q + Q ++
Sbjct: 1126 EMVTQGQTDAQYMFLRQRLQALDTGWNELH---KMWEN--RQNLLSQSHAYQQFLRDTKQ 1180
Query: 6699 WLASAKNRRQ-KAHVTDPKA--DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 6755
A N+ AH P A ++ + + M + + +++ + E L+
Sbjct: 1181 AEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFM---TTMDANEEKINAVVETGRRLVS 1237
Query: 6756 KGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 6795
G+ D I +EKV I+ + ++ RE S+ LM L+ ++
Sbjct: 1238 DGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1276
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 198 bits (503), Expect = 2e-49
Identities = 117/281 (41%), Positives = 163/281 (58%), Gaps = 35/281 (12%)
Query: 24 SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD- 82
+L E+E QKK FT W+NS LAR T + DL++D++ G LL LLEVLSG+ LP+
Sbjct: 50 ALADEREAVQKKTFTKWVNSHLARVTCR--VGDLYSDLRDGRNLLRLLEVLSGEILPKPT 107
Query: 83 KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
KG C N++ AL FL+ + + L N+ DI+DGN + LGL+WTIIL F I+ ++
Sbjct: 108 KGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISV 167
Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
N + + SA+ ALLLW Q + A Y +VN
Sbjct: 168 ETEDN------------------------------KEKKSAKDALLLWCQMKTAGYPNVN 197
Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
V +F +SWR+G+AF AI+H RPDL+D +S+K + NL+ AF +AE+EL + +LL+PE
Sbjct: 198 VHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPE 257
Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQ--GKVKD 301
DV+V PDEKSI+TYVA + Y E + GKV D
Sbjct: 258 DVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLD 298
Score = 70.1 bits (170), Expect = 7e-11
Identities = 119/657 (18%), Positives = 269/657 (40%), Gaps = 65/657 (9%)
Query: 5705 FTTSVENLFRFLTDTSHLLSAVK-GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLE 5763
F ++ +L D L+S+ + G + FS Q + H +EI R T AL +
Sbjct: 752 FQADANDMEAWLVDALRLVSSPELGHDEFST-QALARQHRALEEEIR-SHRPTLDALREQ 809
Query: 5764 AGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ------CEK 5817
A L L V R+ L+ +++++ + E + ++ + + C
Sbjct: 810 AAA---LPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGL 866
Query: 5818 KIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR 5877
++E + L L LPE EDL ++ + LE + + + + + L +
Sbjct: 867 WVEEKEQWLNGLA------LPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920
Query: 5878 HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME 5937
++ Q E L+ +W+ +K + L+ ++ + E AW+ + +
Sbjct: 921 ANPPGKDRIVNTQ-EQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMRE-K 977
Query: 5938 NKVLQTA-----DISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEI 5992
KV+++ D++ +++ ++ + +L + + L A + ++A I
Sbjct: 978 TKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALA-AGHPAQAVAI 1036
Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYD 6052
+ +L ++ W+ L + R + L E +Q +++ + + WL R ++ ++
Sbjct: 1037 NARLREVQTGWEDLRATMRRREESLGEARR-LQDFLRSLDDFQAWLGRTQTAVASEE--G 1093
Query: 6053 VCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRS 6112
E + LA+ L+ ++E+ + + + + + D + +C ++Q +
Sbjct: 1094 PATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQA----DPQCLFLRQRLEA 1149
Query: 6113 LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSA 6172
L W + M R+ ++ + +Q FL D + E L S E + +T
Sbjct: 1150 LGTGWEELGRMWESRQGRLAQAHG-FQGFLRDARQAEGVLSSQEYVLS--------HTEM 1200
Query: 6173 KEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRR 6232
L+ +A +++ + ++ ++ ++ L R Q+V EGN D ++ +
Sbjct: 1201 PGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGR--------QLVSEGNIHADKIREK 1252
Query: 6233 VTAVLRRLRHFTNQREEFEG----TRE---------SILVWLTEMDLQLTNVEHFSESDA 6279
++ RR + + ++F G RE + +W+ E L +V + +
Sbjct: 1253 ADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNL 1312
Query: 6280 DDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV 6336
K ++ F E+ N + +D++ G +L + L A L+ ++L +LHR E+
Sbjct: 1313 HTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA-LVSEKLRDLHRRWDEL 1368
Score = 63.9 bits (154), Expect = 5e-09
Identities = 105/550 (19%), Positives = 223/550 (40%), Gaps = 60/550 (10%)
Query: 5781 GRRISQLQDSWKDMEPQL-------AEMIKQFQSTVETWD--QCEKKIKELKSRLQVLKA 5831
G+RI ++ D + E + +E+++ + T+ T + Q + ++++LQ +
Sbjct: 290 GKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNS 349
Query: 5832 QSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQI 5891
P + N + L+ ++ L + Q + + + L+ D+ E++
Sbjct: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGR-------LISDINKAWERL 402
Query: 5892 EHLHRQWEDLCLRVAIRKQEIEDRL-----------NTWVVFNEKNKELCAWLVQMENKV 5940
E + E L LR + +QE ++L TW+ N++ LV +N
Sbjct: 403 EKAEHERE-LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQR-------LVSQDNFG 454
Query: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
L+ A ++E + K + +E + ++Q + A I + + +
Sbjct: 455 LELA--AVEAAVRK--HEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVA 510
Query: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
W L ++ +R ++L +Q++ +++ L W+ ++ L Q++
Sbjct: 511 RLWDFLRQMVAARRERLLLNLE-LQKVFQDLLYLMDWMEEMKGRLQS---------QDLG 560
Query: 6061 KRLAEQQDLQRDIEQHSAGV----ESVFNICDVLLHDSDACANETECDS--IQQTTRSLD 6114
+ LA +DL + E A + E V + L + CD + + L+
Sbjct: 561 RHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLE 620
Query: 6115 RRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKE 6174
+ + +C ++ RR ++EE+ RLW +FL + E W++ + A ++ L T A
Sbjct: 621 QSYEALCELAAARRARLEESRRLW-RFLWEVGEAEAWVREQQHLLASADTGRDL-TGALR 678
Query: 6175 ELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVT 6234
L + A + ++ RL L+L +Q ++L E AS+ E +W+ L+
Sbjct: 679 LLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG-ASQASARAAELQAQWERLEALAE 737
Query: 6235 AVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVE-HFSESDADDKMRQLNGFQQEI 6293
+RL + +F+ + WL + +++ E E RQ ++EI
Sbjct: 738 ERAQRLAQAAS-LYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
Query: 6294 TLNTNKIDQL 6303
+ +D L
Sbjct: 797 RSHRPTLDAL 806
Score = 59.3 bits (142), Expect = 1e-07
Identities = 86/459 (18%), Positives = 190/459 (41%), Gaps = 36/459 (7%)
Query: 5890 QIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME----------NK 5939
++ L W+ L + +R + +ED L + + E AW+ + E ++
Sbjct: 1562 ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDA-AEAEAWMGEQELHMMGQEKAKDE 1620
Query: 5940 VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKI 5999
+ A++ +++E+ D + I+ QL +I + + I + ++
Sbjct: 1621 LSAQAEVKKHQVLEQALADYAQTIH-------QLAASSQDMIDHEHPE-STRISIRQAQV 1672
Query: 6000 NDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEI 6059
+ + L ++ G R ++L+E Q L + + +L W+ E + +++ D E
Sbjct: 1673 DKLYAGLKELAGERRERLQEHLRLCQ-LRRELDDLEQWIQEREVVAAS---HELGQDYEH 1728
Query: 6060 QKRLAEQ-QDLQRDIEQ-HSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRW 6117
L ++ ++ RD V+S + + L+ A ++ + SL+ W
Sbjct: 1729 VTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA-----TVAEWKDSLNEAW 1783
Query: 6118 RNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELK 6177
++ + R + + L Q+FL + + + + P+ + +A+ +
Sbjct: 1784 ADLLELLDTRGQVLAAAYEL-QRFL--HGARQALARVQHKQQQLPDGTGRDLNAAEALQR 1840
Query: 6178 RFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
R A++ I Q++ + RL + D A + + + + W LQ A
Sbjct: 1841 RHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARR 1900
Query: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE-SDADDKMRQLNGFQQEITLN 6296
+ L T++ F+ RE +++W+ E++LQ+ E + S AD ++ G + EI
Sbjct: 1901 QLLLDTTDKFRFFKAVRE-LMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR 1959
Query: 6297 TNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
++ I G++L+ +S A I ++L +L QE
Sbjct: 1960 ADRFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQE 1997
Score = 52.8 bits (125), Expect = 1e-05
Identities = 60/247 (24%), Positives = 101/247 (40%), Gaps = 20/247 (8%)
Query: 6530 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQ-ELHNK-LKIKQNLQQLNSDISAIT 6587
PR+ + +Q G A + + + W+ + + EL K L+ QQ D +
Sbjct: 1542 PRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
Query: 6588 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTE 6647
W+ E EL M+ K ++ + VK+ Q + +A Y + + SS++ + E
Sbjct: 1602 AWMG--EQELHMMGQEKAKDELSA-QAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
Query: 6648 SPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQ------DFHQLSQNLLLWLA 6701
PEST + R Q+ L+ + R L++ L CQ D Q Q + A
Sbjct: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
Query: 6702 SAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGED 6761
S + + HVT + R E R+ + +E +VD ++N L+ GH
Sbjct: 1719 SHELGQDYEHVTMLRDKFR---EFSRDTSTIGQE------RVDSANALANGLIAGGHAAR 1769
Query: 6762 CIEAEEK 6768
AE K
Sbjct: 1770 ATVAEWK 1776
Score = 47.0 bits (110), Expect = 7e-04
Identities = 47/229 (20%), Positives = 98/229 (42%), Gaps = 17/229 (7%)
Query: 6558 WEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 6615
+E +QA+ E L+ L + S+ A W+++ E L L + P ++++E+
Sbjct: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLAL---PERLEDLEVV 890
Query: 6616 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 6675
+R + + +T A + +VN +++ L+ P + + QL+ W+ + D
Sbjct: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
Query: 6676 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKA----DPRALLECRRELMQ 6731
+ L S + Q++H W+ R+K V + D +L +R+L
Sbjct: 951 KAAL-TSALSIQNYHLECTETQAWM------REKTKVIESTQGLGNDLAGVLALQRKLAG 1003
Query: 6732 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
E++L +V L +N+ L GH + ++ ++ + LR
Sbjct: 1004 TERDLEAIAARVGELTREANA-LAAGHPAQAVAINARLREVQTGWEDLR 1051
Score = 35.0 bits (79), Expect = 2.6
Identities = 69/349 (19%), Positives = 139/349 (39%), Gaps = 21/349 (6%)
Query: 4635 NRSYQNEIKRLYHQL---IKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAK 4691
NR Q+ ++ H+L I K Q ++ +++ + QK A+ EL + + K
Sbjct: 1277 NREQQHFLQDC-HELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDK 1335
Query: 4692 LRDEGERLHLPYALLQEVY--KLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
+ EG L L L+ + KL D L W L + ++ + Q
Sbjct: 1336 VDKEGRELTLEKPELKALVSEKLRD-LHRRWDELETTTQAKARSLFDANRAELFAQSCCA 1394
Query: 4750 LVKIGKEKLAHGHLKQT-KSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNR 4808
L + A H K ++ ++ ++ ++ ++A A+ +++
Sbjct: 1395 LESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ 1454
Query: 4809 ETFWAEQVTEVKILEEKSRQCGMKLQSL---LQKWEEFDENYASLEKDLEILISTLPSVS 4865
E+ + + +EEK R ++ LQ E + + +E ++ + LP S
Sbjct: 1455 GAGEVERTS--RAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMAS 1512
Query: 4866 LVEETEERLVERISFY--QQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEE 4923
+E ++ ++ Q +++ I G R+ + L A+ + PEL A+L+E
Sbjct: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL----AELQE 1568
Query: 4924 QWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWL-ESSQHTLNYWK 4971
W L +++ RL+ L+ Y RD+ + W+ E H + K
Sbjct: 1569 MWKRLGHELELRGKRLEDALRAQQFY-RDAAEAEAWMGEQELHMMGQEK 1616
Score = 33.9 bits (76), Expect = 5.8
Identities = 91/577 (15%), Positives = 217/577 (37%), Gaps = 68/577 (11%)
Query: 4822 LEEKSRQC-GMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
+EEK + G+ L L+ E + + +LE ++ L + + +V+ + E
Sbjct: 868 VEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAE----------- 916
Query: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
Q +K N GK R+ T + L +W + D + L
Sbjct: 917 -QLLKANPPGKD-RIVNTQEQ-------------------LNHRWQQFRRLADGKKAALT 955
Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
+ L + +Y+ + + W+ + E + + DL + + ++++
Sbjct: 956 SALS-IQNYHLECTETQAWMREKTKVI----ESTQGLGNDLAGVLALQRKLAGTERDLEA 1010
Query: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
++ + N L + A L + + W L + +E L + + +
Sbjct: 1011 IAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ-D 1069
Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ 5120
+++ + +W+ + + E+ P++ + + LL +H R E++ Q +
Sbjct: 1070 FLRSLDDFQAWLGRTQTAVASEEG---PATLPEAEALLAQHAALRGEVERAQSEYSRLRA 1126
Query: 5121 SLLQLSTCDVESKRYERTEFAEHLG----EMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
+++ + + + E LG E+ R W G L + + L ++E
Sbjct: 1127 LGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL-AQAHGFQGFLRDARQAE 1185
Query: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL 5236
L +QE L + P ++ + + +D + + + + L L
Sbjct: 1186 GV-------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGL------L 1232
Query: 5237 ESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIY-DQLYDEVNMMTIR 5295
E+G L+ + D++ +K S+ + + + + Q L + +Q + + ++
Sbjct: 1233 EAGR-QLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELK 1291
Query: 5296 FWYCMEHSKPVVLSLE---TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVA 5352
W + +S + L + + Q+ E +++ +K+ + +L P +
Sbjct: 1292 LWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELK 1351
Query: 5353 EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389
++ EK ++ H+RW ++ KA+SL +A
Sbjct: 1352 ALVSEKLRDLHRRWDELETTTQ---AKARSLFDANRA 1385
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 197 bits (501), Expect = 3e-49
Identities = 124/327 (37%), Positives = 182/327 (55%), Gaps = 49/327 (14%)
Query: 24 SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD- 82
+L E+E QKK FT W+NS LAR + I+DL+ D++ G +L+ LLEVLSG+ LP+
Sbjct: 47 ALADEREVVQKKTFTKWVNSHLARVSCR--ITDLYKDLRDGRMLIKLLEVLSGEMLPKPT 104
Query: 83 KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
KG C N++ AL FL+ + + L N+ DI+DGN ++LGLIWTIIL F I+ +
Sbjct: 105 KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI-- 162
Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
VV + + R SA+ ALLLW Q + A Y VN
Sbjct: 163 ---------------VVQTQ-------------EGRETRSAKDALLLWCQMKTAGYPHVN 194
Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
VT+F SSW++G+AF A+IH RPDLID +K + + NL AF +AE++L I LL+PE
Sbjct: 195 VTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPE 254
Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDS-E 321
DV +PDEKSI+TYV F Y M L ++ +++ K++ + E
Sbjct: 255 DVFTENPDEKSIITYVVAFYHYF---------------SKMKVLAVEGKRVGKVIDHAIE 299
Query: 322 NDTYFKKYNSLLSFMESFNEEKKSFLD 348
+ +KY+ L S + ++ E+ + L+
Sbjct: 300 TEKMIEKYSGLASDLLTWIEQTITVLN 326
Score = 86.7 bits (213), Expect = 7e-16
Identities = 140/667 (20%), Positives = 274/667 (41%), Gaps = 84/667 (12%)
Query: 4770 VALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQC 4829
+A+Q ++ + + A + ++ S +++ S + +E Q K LEE +
Sbjct: 991 IAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ----KHLEELWQGL 1046
Query: 4830 GMKLQSLLQKWEEFDENYASLEK--DLEILISTLPSVSLVEETEERLVERISFYQQ---I 4884
LQ E + A L+ D + +S E+ E L E QQ I
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106
Query: 4885 KRNIGGKHARLYQTLNE-GKQLVASVSCPE---LEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
K I G H YQ + E G++++ + PE L ++ L+ W +L + + H L
Sbjct: 1107 KDEIDG-HQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
L + +D+ Q L + ++TL + L L+ + I F +F ++
Sbjct: 1166 QCLG-FQEFQKDAKQAEAILSNQEYTLAH-----LEPPDSLEAAEAGIRKFEDFLGSMEN 1219
Query: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFE----------QKWTMLITQLPDIQEK 5050
+ + GN+L+ + ++ + E Q+ ++L+ ++Q
Sbjct: 1220 NRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNF 1279
Query: 5051 LHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEM-D 5109
L Q E+ W+N+ + D S A + + KH+ F E+
Sbjct: 1280 LQNCQ-----------ELTLWINDKLLTSQDV----SYDEARNLHNKWLKHQAFVAELAS 1324
Query: 5110 YKQWIVDFVNQSLLQLSTCDVESKRY--ERTEF----AEHLGEMNRQWHRVHGMLNRKIQ 5163
++ W L D E K+ E+ +F ++ L ++R W + K Q
Sbjct: 1325 HEGW-----------LENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ 1373
Query: 5164 HLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKS 5223
HL S + LN W+ A E++L++ + + SV ++L + +E+Q+ ++
Sbjct: 1374 HLSAARSSDLRLQTHAD-LNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRK 1432
Query: 5224 KALDELKQSYLTLESGAVPLLEDTASRIDELFQKR-SSVLTQVNQLKTSMQSVLQEWKIY 5282
+ L EL VP + + D +KR +L + + K ++S + +I
Sbjct: 1433 EELGEL--------FAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQIS 1484
Query: 5283 DQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIG 5342
L DE + R + S +L+T++ ++ Q+LQ+E G ++++V+
Sbjct: 1485 RDLEDETLWVEERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEI---LGHTPRVEDVLQ 1539
Query: 5343 KLKGLCPSVAEI----IEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAA 5398
+ + L AEI +EE+ + W ++ +A A +LQ+ + + + Y +A EA
Sbjct: 1540 RGQQLV-EAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAE 1597
Query: 5399 ARLKQQE 5405
A + +QE
Sbjct: 1598 AWIGEQE 1604
Score = 85.1 bits (209), Expect = 2e-15
Identities = 247/1271 (19%), Positives = 483/1271 (38%), Gaps = 214/1271 (16%)
Query: 5161 KIQHLEQLLESITESEN----------KIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
+++ LE L + + E EN K IL W QE Q+ E+ +++QKL
Sbjct: 477 RVRALEDLAQEL-EKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLF- 534
Query: 5211 DCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKR----SSVLTQVN 5266
QD+ + + +DE+K L+ E G LLE +++L QK + + Q +
Sbjct: 535 --QDMLHSI----DWMDEIKAHLLSAEFGK-HLLE-----VEDLLQKHKLMEADIAIQGD 582
Query: 5267 QLKTSMQSVLQ--EWKIYDQLYDEVNMMTI-RFWYCMEHSKPVVLSLETLRCQVENLQSL 5323
++K + L+ E K Y +V I C E + + Q + L
Sbjct: 583 KVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKF 642
Query: 5324 QDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSL 5383
E + +E SW K +E I + ++ Q HK A D+L+ +
Sbjct: 643 FWEMDEAE-SWIKEKEQIYSSLDYGKDLTSVLI--LQRKHK-------AFEDELRGLDAH 692
Query: 5384 LQLWKAYSNAHGEAA----------ARLKQQEAKFQQLANISMSGNNLAEILPPALQDIK 5433
L+ + + AHG A AR+K+ A++ QL +LA LQD +
Sbjct: 693 LE--QIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQL-------KDLAAFCKKNLQDAE 743
Query: 5434 ---ELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKAN 5490
+ Q D K A+LQ++ H LL G A
Sbjct: 744 NFFQFQGDADDLK-AWLQDA--------------HRLLSGEDVGQDEGAT---------- 778
Query: 5491 EFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEH 5550
+ + KDF LE +G++ H L QQ + P+ F + SPD+ H
Sbjct: 779 --RALGKKHKDFLEELEESRGVMEH-------LEQQAQGFPEEFRD--------SPDVTH 821
Query: 5551 LNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLE 5610
++ L+ + +Q + +R E + CE W+ E
Sbjct: 822 -------------RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMG--E 866
Query: 5611 KIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEF 5670
K + ++++ ++L +L Q + +L+ E+ T D + L+++ +R E
Sbjct: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EV 925
Query: 5671 ITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK--G 5728
L RWQ V +R+ VD +R ++ E +++TD + ++ + K G
Sbjct: 926 KQYQDHLNTRWQAFQTLVSERREAVDSALRV-HNYCVDCEETSKWITDKTKVVESTKDLG 984
Query: 5729 QERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQ 5788
++ + + + L+ Q R LE + L+ + + KE +G+R L+
Sbjct: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDA----LERESQQLMDSHPEQKEDIGQRQKHLE 1040
Query: 5789 DSWKDMEPQLAEM------IKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHE 5842
+ W+ ++ L + Q Q+ ++ D + + ++ V + LPE +
Sbjct: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLS--ITQKAVASEDMPESLPEAEQ 1098
Query: 5843 DLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLC 5902
L + E++ S+ Q +KE + + + ++L +++E L W L
Sbjct: 1099 LLQQHAGIKDEIDGHQDSY-QRVKE---SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALG 1154
Query: 5903 LRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ------ 5956
R + L F E K+ + N+ A + + +E +
Sbjct: 1155 RMWESRSHTLAQCLG----FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKF 1210
Query: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASN------KSRAAEIDDKLNKINDRWQHLFDVI 6010
+D + + + L G++L+ N K + I+D+ K N++ Q ++
Sbjct: 1211 EDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLL 1270
Query: 6011 GSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQ 6070
++ +Q +N L W+ + S+ V YD + + + + + Q
Sbjct: 1271 RDNLE--------LQNFLQNCQELTLWI-NDKLLTSQDVSYD--EARNLHNKWLKHQAFV 1319
Query: 6071 RDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMK 6130
++ H +E++ L+ + + Q +L R W + A + E+
Sbjct: 1320 AELASHEGWLENIDAEGKQLMDEKPQFT-----ALVSQKLEALHRLWDELQATTKEKTQH 1374
Query: 6131 IEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERL 6190
+ R L ++ W+ + E + + L TS L + + + Q++ R
Sbjct: 1375 LSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDPGKDL-TSVNRMLAKLKRVEDQVNVR- 1431
Query: 6191 TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL----RRLRHFTNQ 6246
+E + +++ M EG ++++R +L RR + +
Sbjct: 1432 --------------KEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESS 1477
Query: 6247 REEFEGTR--ESILVWLTEMDLQLTNVEHFSES--DADDKMRQLNGFQQEITLNTNKIDQ 6302
R + + +R E +W+ E L L + + M++ Q EI +T +++
Sbjct: 1478 RAKLQISRDLEDETLWVEER-LPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELH----RYCQEVFGRVSRFHRRLTSCTPGLEDEK 6358
++ G+QL++ +E +D +E+ L L R + GR+ R L D
Sbjct: 1537 VLQRGQQLVEAAE-IDCQDLEERLGHLQSSWDRLREAAAGRLQR-----------LRDAN 1584
Query: 6359 EASENETDMED 6369
EA + D ++
Sbjct: 1585 EAQQYYLDADE 1595
Score = 80.9 bits (198), Expect = 4e-14
Identities = 321/1828 (17%), Positives = 685/1828 (37%), Gaps = 246/1828 (13%)
Query: 4673 QKADAYTVELENAESRVAKLRDEGERLHLP-YALLQEVYKLEDVLDSMWGMLRARYTELS 4731
+K +A + E RV L D + L Y + + +D + +W L+
Sbjct: 462 KKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRR 521
Query: 4732 SPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQ--IENHKVFFQKLVAD 4789
T L Q M+ + E AH L K L+ + ++ HK+ +
Sbjct: 522 QRLETTLALQKLFQDMLHSIDWMDEIKAH-LLSAEFGKHLLEVEDLLQKHKLMEADIAIQ 580
Query: 4790 MLLIQAYSAKIL------------PSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
++A +A L P ++Q+R + + E+ + + + + L
Sbjct: 581 GDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLW 640
Query: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ 4897
+ + E DE + +++ +I S L T +++R ++ + + G A L Q
Sbjct: 641 KFFWEMDEAESWIKEKEQIYSSLDYGKDL---TSVLILQRK--HKAFEDELRGLDAHLEQ 695
Query: 4898 TLNEGKQLVA--SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQ 4955
E +VA P++E +I ++ QW L LQ ++ + D+D
Sbjct: 696 IFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADD 754
Query: 4956 LTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQL 5015
L WL+ + L+ +V QD R+ +F +E++E + + Q
Sbjct: 755 LKAWLQDAHRLLS-----GEDVGQDEGATRALGKKHKDFLEELEESRGVME---HLEQQA 806
Query: 5016 LHLKET--DTATLRASLAQFEQKWTMLITQLPDIQEKLHQ-LQMEKLPSRKAITEMISWM 5072
E D+ + L + + ++ Q Q++L + L + + E+ WM
Sbjct: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL--WM 864
Query: 5073 NNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVES 5132
E ++ + P + ++ + + EM +D VN + L VES
Sbjct: 865 GEKEKWLAE---MEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL----VES 917
Query: 5133 KRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEER 5192
E ++ +N +W +++ + + ++ L ++N+ EE
Sbjct: 918 GHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALR-----------VHNYCVDCEET 966
Query: 5193 LKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID 5252
K + V+ K L +D+ +AI+ K L L++ +++ L ++ +D
Sbjct: 967 SKWITDKTKVVESTKDL--GRDLAGIIAIQRK-LSGLERDVAAIQARVDALERESQQLMD 1023
Query: 5253 ELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMT--------IRFWYCMEH-- 5302
+++ + + L+ Q + Q + + L EV+ + + W +
Sbjct: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083
Query: 5303 --SKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGK-LKGLCPSVAEIIEEKC 5359
S+ + SL ++ ++DE + + S+++++E K ++G ++ ++
Sbjct: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143
Query: 5360 QNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGN 5419
+ W +L ++W++ S+ + + Q+ Q A +S
Sbjct: 1144 EGLDTGWN--------------ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189
Query: 5420 NLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAA 5479
LA + PP ++ + ++K ++ + D++ P +S ++ G L+S +
Sbjct: 1190 TLAHLEPP--DSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK--- 1244
Query: 5480 YLEKMLLV---------KANEFEFVLSQFKDFGVRLESLKGLIMHEEENL----DRLHQQ 5526
EK+ L+ KA E +L + L++ + L + + L D + +
Sbjct: 1245 IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDE 1304
Query: 5527 EKENPDSFLNH---VLALTAQSPDIEHLNEVSLKL-----PLSDVAVKTLQNMNRQWIRA 5578
+ + +L H V L + +E+++ +L + + + L+ ++R W
Sbjct: 1305 ARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDEL 1364
Query: 5579 TATALERCSELQGIGLNEKFLYC---CEKWIQLLEKIEEALKVDVANSLPELLEQQKTYK 5635
AT E+ L ++ L KWI +E ++ D L + K
Sbjct: 1365 QATTKEKTQHLSAARSSDLRLQTHADLNKWISAME--DQLRSDDPGKDLTSVNRMLAKLK 1422
Query: 5636 MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDV 5695
+E +V++ + E E + + + +A + +R D+
Sbjct: 1423 RVEDQVNVRK-------------------EELGELFAQVPSMGEEGGDADLSIEKRFLDL 1463
Query: 5696 -DGLVRQWQDFTTSVENL--FRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQ 5752
+ L R+ + +S L R L D + + +ER L Q+ L+ ++ +
Sbjct: 1464 LEPLGRRKKQLESSRAKLQISRDLEDETLWV-----EERLPLAQSADYGTNLQTVQLFMK 1518
Query: 5753 RRRTT----------CALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMI 5802
+ +T L+ G++L+ ++ ++ + R+ LQ SW + A +
Sbjct: 1519 KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD-LEERLGHLQSSWDRLREAAAGRL 1577
Query: 5803 KQFQSTVETW------DQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQ 5856
++ + E D+ E I E L V+ D +P+ E + ++
Sbjct: 1578 QRLRDANEAQQYYLDADEAEAWIGE--QELYVIS----DEIPKDEEGAIVMLKRHLRQQR 1631
Query: 5857 SLASWTQNLKELQTMKADLTR--HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
++ + +N+K+L + L H E ++ L+ Q++ + +D+ RK+++E+
Sbjct: 1632 AVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE---RKRKLEN 1688
Query: 5915 RLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCMEEINLFSENKL 5971
+ + + E + +L W+ + E + D ++ +D E + ++
Sbjct: 1689 MYHLFQLKRETD-DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERV 1747
Query: 5972 Q-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKN 6030
+ ++LI A + S AA I + + +N+ W L ++I +R++ L ++ + +
Sbjct: 1748 DNVNAFIERLIDAGH-SEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYD-LHRYFYT 1805
Query: 6031 MSNLRTWLARIESELSKPVVYDVCDDQEIQK-RLAEQQDLQRDIEQHSAGVESVFNICDV 6089
+ + + EL + V D + + A +++L H GV+ V DV
Sbjct: 1806 GAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFEREL------HLLGVQ-VQQFQDV 1858
Query: 6090 LLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEET---WRLWQKFLDDYS 6146
A A E + ++IQ + + W+ + RR ++ +T +R + D S
Sbjct: 1859 ATRLQTAYAGE-KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLS 1917
Query: 6147 RFEDWLKSAERTAACPNSSEV---------LYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
E ++ E + S V + + K F A ++ E L Q +
Sbjct: 1918 WMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACL-ELGESLLQRQ--- 1973
Query: 6198 KQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESI 6257
Q RE SR K+M + RW+ L+ +L + F+ E
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLR-----MLLEVCQFSRDASVAE------ 2022
Query: 6258 LVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPL 6317
WL + L + + D+ +K+ + + ++ T + + E+ +P
Sbjct: 2023 -AWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS---------WAERFAALEKPT 2072
Query: 6318 DAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDS 6377
L E ++ E P E + E ET E P +
Sbjct: 2073 TLELKERQIAE----------------------RPAEETGPQEEEGETAGEAPVSHHAAT 2110
Query: 6378 WRKRGESEEPSSPQSLCHLVAPGHERSG 6405
R EE + PQ+L PG + G
Sbjct: 2111 ERTSPGEEEGTWPQNLQQPPPPGQHKDG 2138
Score = 53.9 bits (128), Expect = 5e-06
Identities = 52/245 (21%), Positives = 104/245 (42%), Gaps = 17/245 (6%)
Query: 6562 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 6621
QA +L+ +L + + A W+ + E L ++M D++ ++ R L +
Sbjct: 836 QADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQ 895
Query: 6622 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6681
+K T + VN+++ +++ P S E++ L+ W+A Q V R +
Sbjct: 896 EMKTLMTQ---IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 6682 SLM---QCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVE 6738
+L C D + S+ W+ + D D ++ +R+L LE+++
Sbjct: 953 ALRVHNYCVDCEETSK----WITD--KTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAA 1006
Query: 6739 RQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPAS 6798
Q +VD L+ S L+ + E +E + +K L++L + + Q L + S
Sbjct: 1007 IQARVDALERESQQLM-----DSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVS 1061
Query: 6799 PLPSF 6803
L +F
Sbjct: 1062 QLQAF 1066
Score = 47.4 bits (111), Expect = 5e-04
Identities = 167/882 (18%), Positives = 346/882 (39%), Gaps = 130/882 (14%)
Query: 1871 VEQKLQKLSDFLTLEGRNSKIKQ----------VDSVLKHVKKHLPKAHVKELISWLVGQ 1920
V+Q+LQ S + T+E + K ++ + S ++ + + H +L+S +
Sbjct: 337 VQQQLQAFSTYRTVE-KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRA 395
Query: 1921 EFELEKMESICQ-ARAKEL--EDSLQQLLRLQDDHRNLRK-WLTNQEE---------KWK 1967
LE+ E + A EL ++ L+QL R D +R+ WL+ +
Sbjct: 396 WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455
Query: 1968 GMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLR 2027
+E +K E A E+ ++ L L++ + +++ I ++ + L
Sbjct: 456 AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515
Query: 2028 QLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIK--- 2084
L + + + F D+ H I W+ EIK L+ + + +E+ +QK K
Sbjct: 516 LLQSRRQRLETTLALQKLFQDMLHS-IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLME 574
Query: 2085 -EIILLKPEGDARIETIMKQAESS-----EAPLVQKTLTDISNQWDNTLHLAS---TYLS 2135
+I + + A +K E + ++Q ++ + ++ ++A+ L
Sbjct: 575 ADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLE 634
Query: 2136 HQEKL------LLEGEKYLQSKE----------DLRLMLIELKKKQEAGFALQHGLQEKK 2179
++L + E E +++ KE DL +LI L++K +A GL
Sbjct: 635 QSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLI-LQRKHKAFEDELRGLDAHL 693
Query: 2180 AQL------KIYKKFLKKAQDLTSLLKELKSQGNYLLE----CTKNPSFSEEPWLEIKHL 2229
Q+ + +K Q + + +KE+ +Q + L + C KN +E + + +
Sbjct: 694 EQIFQEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAEN-FFQFQGD 751
Query: 2230 HESLLQQLQDSVQNLDGH------------VREHDSYQVCVTDLNTTLDNFSKEFVSFSD 2277
+ L LQD+ + L G ++H + + + +++ ++ F +
Sbjct: 752 ADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE 811
Query: 2278 KPVDQIAVEEKLQKLQELENRL----SLQDGTLKKILALAKSVKQNTSS---VGQK---- 2326
+ D V +LQ L+EL ++ L+ L++ L L + + +G+K
Sbjct: 812 EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWL 871
Query: 2327 ---IIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQAT 2383
+ D ++ L+ +++R QEM+ + I G A
Sbjct: 872 AEMEMPDTLEDLEV----VQHRFDILDQEMKTLMTQI---------------DGVNLAAN 912
Query: 2384 SDVQESTQESAAVEKLEED----WEI------NKDSAVEMAMS-KQLSLNAQESMKNTED 2432
S V+ S V++ ++ W+ + AV+ A+ ++ +E+ K D
Sbjct: 913 SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
Query: 2433 ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLH 2492
+ KV E + L D ++ L + A +A + LE+ E ++
Sbjct: 973 KTKVVE-STKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALER-ESQQLMDSHPEQKE 1030
Query: 2493 NIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKAL-LTDKESLKVGPL 2551
+IG +HL+ L Q L + +E + Q +L ++ L +T K
Sbjct: 1031 DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090
Query: 2552 DSVTYLDKIKKFIASIEKE----KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGW 2607
+S+ +++ + A I+ E +DS +K E + TD + LL +++ L+ GW
Sbjct: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGW 1150
Query: 2608 EQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHL 2649
+ + + + S + + F + E L Q+ L
Sbjct: 1151 NALGRMWESR-SHTLAQCLGFQEFQKDAKQAEAILSNQEYTL 1191
Score = 46.6 bits (109), Expect = 9e-04
Identities = 152/792 (19%), Positives = 306/792 (38%), Gaps = 122/792 (15%)
Query: 1491 ANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTE---CLEQCGRVLELLKQYQNFKSIL 1547
ANSL R + V Q + W+ + LV+E ++ RV + +
Sbjct: 911 ANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWI 970
Query: 1548 TTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
T + ES L G ++++++ +E ++ +++ +Q
Sbjct: 971 TDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQ----------- 1019
Query: 1608 MKTFEEPPFEKE-----ANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW- 1661
+ + P +KE + + W + + + + LG L L +L + W
Sbjct: 1020 -QLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD-FQAWL 1077
Query: 1662 --TEKALQKMELHQLTEEDRERL------KEELQVHE---QKTSEFSRRVAEIQFLLQSS 1710
T+KA+ ++ + E + L K+E+ H+ Q+ E +V + Q +
Sbjct: 1078 SITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYL 1137
Query: 1711 EIPLELQVMES--SILNKMEHVQKCLTGESNCHALSGSTA--ELREDLDQAKTQIGMTES 1766
+ L+ +++ + L +M ES H L+ E ++D QA+ + E
Sbjct: 1138 LLGQRLEGLDTGWNALGRM--------WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189
Query: 1767 LLKALSPSDSLEI----FTKLEEIQQQILQQKHSMILLENQIGCLTPE----LSELKKQY 1818
L L P DSLE K E+ + + ++ + L E ++K++
Sbjct: 1190 TLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKV 1249
Query: 1819 ESVSDLFNTKKSVLQDHFSKLLND---------QCKNFNDWFSNIKVNLKECFESSETKK 1869
+ + D Q+ S LL D C+ W ++ + ++ S + +
Sbjct: 1250 QLIEDRHRKNNEKAQE-ASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDV--SYDEAR 1306
Query: 1870 SVEQKLQKLSDFLT-LEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFE-LEKM 1927
++ K K F+ L ++ +D+ K + P+ + LV Q+ E L ++
Sbjct: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ------FTALVSQKLEALHRL 1360
Query: 1928 ESICQARAKELEDSLQQL----LRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQAL 1983
QA KE L LRLQ H +L KW++ E++ + ++PG+ + L
Sbjct: 1361 WDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS-DDPGKDLTSVNRML 1418
Query: 1984 A-----------RKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEI 2032
A RK E E AQ+ + +E G + ++ +E +D + L R+ ++
Sbjct: 1419 AKLKRVEDQVNVRKEELGELFAQVPSMGEEGG---DADLSIEKR-FLDLLEPLGRRKKQL 1474
Query: 2033 EEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPE 2092
E L Q DL + + W ++E L + S++ L+ +K+ L+ E
Sbjct: 1475 ESSRAKL----QISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526
Query: 2093 ---GDARIETIMK------QAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLE 2143
R+E +++ +A + +++ L + + WD A+ L
Sbjct: 1527 ILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEA 1586
Query: 2144 GEKYLQSKE--------DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDL 2195
+ YL + E +L ++ E+ K +E + L+ Q + + + + + L
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVM---LKRHLRQQRAVEDYGRNIKQL 1643
Query: 2196 TSLLKELKSQGN 2207
S + L S G+
Sbjct: 1644 ASRAQGLLSAGH 1655
Score = 41.6 bits (96), Expect = 0.028
Identities = 298/1591 (18%), Positives = 596/1591 (37%), Gaps = 270/1591 (16%)
Query: 1807 LTPELSELKKQYESVSDLFNTKKSVLQDHFS--KLLNDQCKNFNDWFSNIKVNLKECFES 1864
+T + + + + +L +++ L+ + KL D + DW IK +L E
Sbjct: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSA-EF 556
Query: 1865 SETKKSVEQKLQK---LSDFLTLEGRNSKIKQVDSV-LKHV--KKHLP--KAHVKELISW 1916
+ VE LQK + + ++G K+K + + LK K + P +++ IS
Sbjct: 557 GKHLLEVEDLLQKHKLMEADIAIQG--DKVKAITAATLKFTEGKGYQPCDPQVIQDRISH 614
Query: 1917 LVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKT 1976
L E E++ ++ R +LE S ++L + + W+ +E+ + ++ + T
Sbjct: 615 L---EQCFEELSNMAAGRKAQLEQS-KRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
Query: 1977 ELFCQALARKREQFESV-----AQLNN---------SLKEYGFTEEEEIIMEATCLMDRY 2022
+ L RK + FE A L + K++G + E I E + D+
Sbjct: 671 SVLI--LQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQL 728
Query: 2023 QTLL----RQLSEIE-----------------EEDKLLPTEDQSFNDLAHDVIHWIKEIK 2061
+ L + L + E + +LL ED ++ A + K+ K
Sbjct: 729 KDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALG--KKHK 786
Query: 2062 ESLMVLNSSEGKMP-LEERIQKIKEIILLKPEGDARIETIMK--QAESSEAPLVQKTLTD 2118
+ L L S G M LE++ Q E P+ R++ + + Q ++A L Q+ L +
Sbjct: 787 DFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
Query: 2119 ISNQWD--NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQ 2176
+ + ++ +EK L E E + EDL ++ QH
Sbjct: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMP-DTLEDLEVV--------------QHRFD 891
Query: 2177 EKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQ 2236
++K L + + + N L+E S + + + + Q
Sbjct: 892 ILDQEMKT----------LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Query: 2237 L-QDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQEL 2295
L + + +D +R H+ Y V + + + + +K S D D + +KL L
Sbjct: 942 LVSERREAVDSALRVHN-YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000
Query: 2296 ENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMEC 2355
E ++ ++ AL + +Q S ++ K+DI Q ++L L + Q E
Sbjct: 1001 ERDVAAIQA---RVDALERESQQLMDSHPEQ--KEDIGQRQKHLEELWQGLQQSLQGQED 1055
Query: 2356 CLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAM 2415
L + + + + F QA + TQ++ A E + E + + A
Sbjct: 1056 LLGEVSQLQAFLQDLDDF-------QAWLSI---TQKAVASEDMPESLPEAEQLLQQHAG 1105
Query: 2416 SKQLSLNAQESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQL----EAKKA 2470
K Q+S + ++ KV + Q P + +L ++LE ++ + L E++
Sbjct: 1106 IKDEIDGHQDSYQRVKESGEKVIQGQTDP---EYLLLGQRLEGLDTGWNALGRMWESRSH 1162
Query: 2471 AIKP-LEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYL 2529
+ L E + +L N Y+ HL+ + E+ +R F+++L
Sbjct: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP--------PDSLEAAEAGIRKFEDFL 1214
Query: 2530 AAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIE----------KEKDSLGNLKI 2579
++E++ +L+ +S + Y DKIK+ + IE +E L +
Sbjct: 1215 GSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL 1274
Query: 2580 KWENLSNHVTDM----DKKLLESQ------IKQLEHGW-------------EQVEQQIQK 2616
+ +N + ++ + KLL SQ + L + W E + I
Sbjct: 1275 ELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
Query: 2617 KYSQQVVEYDEFTTLMNKV--------QDTEISLQQQQQHL------QLRLKSPEERAGN 2662
+ Q + E +FT L+++ + + + +++ QHL LRL++ + N
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL--N 1392
Query: 2663 QSMIALTTDLQATKHGFSVLKGQAEL-QMKRIWGEKEKKNLEDG---------------- 2705
+ + A+ L++ G + L ++KR+ + + E G
Sbjct: 1393 KWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDA 1452
Query: 2706 -INNLKKQWETLEPL---HLEAENQIKKCDIRNKMKETILWAKNLLG-ELNPSIPLLPDD 2760
++ K+ + LEPL + E+ K I +++ LW + L +
Sbjct: 1453 DLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQT 1512
Query: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
+ ++K + + IL VE + + + V + + DL L L++ + L
Sbjct: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEA-AEIDCQDLEERLGHLQSSWDRLRE 1571
Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHH--- 2873
+ R Q+L E ++ + + + E E + IP+ E A LK H
Sbjct: 1572 AAAGRLQRLR-DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI-VMLKRHLRQ 1629
Query: 2874 ------------------HVTLEASQKELQEI---DSGISTHLQELTNIYEELNVFERLF 2912
L A E ++I + H L ++ EE +L
Sbjct: 1630 QRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERK--RKLE 1687
Query: 2913 LEDQLKNLKIRTNRIQRFIQ---------NTCNEVEH----KIKFCRQFHEKTSAL-QEE 2958
L LK T+ ++++I + +H + KF R F +T A+ QE
Sbjct: 1688 NMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKF-RDFARETGAIGQER 1746
Query: 2959 ADSIQRNELLLNQEVNKGVKE--EIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQ 3016
D++ + + ++ G E I KD L + +L+++ + + ++D +
Sbjct: 1747 VDNV---NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTR--MQLLAASYDLHR 1801
Query: 3017 LDQLQTQVF----EKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLK 3071
++ EK +EL E + T E H + A ++ + +Q+++ +V +
Sbjct: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
Query: 3072 APDSSPESRRLNAQILSQRIEKA-KCLCDEIIKKLNENKTFDDSFK------------EK 3118
+ + Q Q + A + L D + + D F+ E
Sbjct: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
Query: 3119 EILQIKLNAEEND-----KLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQ 3173
I QI+ D L K Q + E+ + + C + E+ L +Q +++
Sbjct: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
Query: 3174 QPLLINLEIKHIQNEKDNCEAFQEQVWAEMC 3204
+ L + + NEK + ++ E+C
Sbjct: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVC 2012
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 245,556,617
Number of Sequences: 37866
Number of extensions: 11113794
Number of successful extensions: 61817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 1093
Number of HSP's that attempted gapping in prelim test: 37896
Number of HSP's gapped (non-prelim): 16084
length of query: 6907
length of database: 18,247,518
effective HSP length: 126
effective length of query: 6781
effective length of database: 13,476,402
effective search space: 91383481962
effective search space used: 91383481962
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 74 (33.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.