Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 118918403

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118918403 spectrin repeat containing, nuclear envelope 2
isoform 1 [Homo sapiens]
         (6885 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118918403 spectrin repeat containing, nuclear envelope 2 isof...  1.354e+04   0.0  
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof...  1.352e+04   0.0  
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...  2247   0.0  
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...  2246   0.0  
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof...  1954   0.0  
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo...  1026   0.0  
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof...   935   0.0  
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo...   809   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                        234   3e-60
gi|221316622 dystonin isoform 3 [Homo sapiens]                        234   3e-60
gi|221316618 dystonin isoform 2 [Homo sapiens]                        234   3e-60
gi|34577047 dystonin isoform 1 [Homo sapiens]                         234   3e-60
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             234   3e-60
gi|19923599 calmin [Homo sapiens]                                     224   3e-57
gi|110611228 utrophin [Homo sapiens]                                  223   5e-57
gi|33188445 microfilament and actin filament cross-linker protei...   212   1e-53
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        206   6e-52
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        204   2e-51
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        204   2e-51
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        204   2e-51
gi|33188443 microfilament and actin filament cross-linker protei...   203   4e-51
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       203   4e-51
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       203   4e-51
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        203   4e-51
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        203   4e-51
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   202   7e-51
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   202   1e-50
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...   200   5e-50
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          198   2e-49
gi|67782321 spectrin beta isoform a [Homo sapiens]                    197   3e-49

>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
            [Homo sapiens]
          Length = 6885

 Score = 1.354e+04 bits (35136), Expect = 0.0
 Identities = 6885/6885 (100%), Positives = 6885/6885 (100%)

Query: 1    MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
            MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD
Sbjct: 1    MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60

Query: 61   IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
            IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN
Sbjct: 61   IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120

Query: 121  PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
            PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ
Sbjct: 121  PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180

Query: 181  MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
            MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD
Sbjct: 181  MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240

Query: 241  NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300
            NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK
Sbjct: 241  NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300

Query: 301  DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360
            DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD
Sbjct: 301  DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360

Query: 361  KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420
            KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV
Sbjct: 361  KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420

Query: 421  TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480
            TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL
Sbjct: 421  TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480

Query: 481  LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540
            LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
Sbjct: 481  LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540

Query: 541  KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600
            KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA
Sbjct: 541  KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600

Query: 601  CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660
            CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK
Sbjct: 601  CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660

Query: 661  LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720
            LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE
Sbjct: 661  LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720

Query: 721  KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780
            KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF
Sbjct: 721  KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780

Query: 781  DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840
            DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV
Sbjct: 781  DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840

Query: 841  SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
            SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV
Sbjct: 841  SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900

Query: 901  EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960
            EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI
Sbjct: 901  EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960

Query: 961  NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
            NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK
Sbjct: 961  NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020

Query: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
            DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE
Sbjct: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080

Query: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140
            KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD
Sbjct: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140

Query: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200
            FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK
Sbjct: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200

Query: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260
            ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH
Sbjct: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260

Query: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320
            LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED
Sbjct: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320

Query: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380
            TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC
Sbjct: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380

Query: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440
            LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL
Sbjct: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440

Query: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500
            KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG
Sbjct: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500

Query: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560
            REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL
Sbjct: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560

Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
            QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA
Sbjct: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620

Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
            NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE
Sbjct: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680

Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740
            RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC
Sbjct: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740

Query: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800
            HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL
Sbjct: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800

Query: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860
            ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE
Sbjct: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860

Query: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920
            CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ
Sbjct: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920

Query: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980
            EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC
Sbjct: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980

Query: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040
            QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP
Sbjct: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040

Query: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100
            TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI
Sbjct: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100

Query: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
            MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE
Sbjct: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160

Query: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220
            LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE
Sbjct: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220

Query: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280
            EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV
Sbjct: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280

Query: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340
            DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK
Sbjct: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340

Query: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400
            DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE
Sbjct: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400

Query: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460
            EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK
Sbjct: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460

Query: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
            LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC
Sbjct: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520

Query: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK
Sbjct: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580

Query: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
            WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI
Sbjct: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640

Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
            SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK
Sbjct: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700

Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760
            NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD
Sbjct: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760

Query: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
            ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL
Sbjct: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820

Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
            KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS
Sbjct: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880

Query: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940
            QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH
Sbjct: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940

Query: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000
            KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK
Sbjct: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000

Query: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
            LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL
Sbjct: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
            QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120

Query: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180
            LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL
Sbjct: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180

Query: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
            EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL
Sbjct: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240

Query: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300
            NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ
Sbjct: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300

Query: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
            EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN
Sbjct: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360

Query: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
            YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL
Sbjct: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420

Query: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480
            RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER
Sbjct: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480

Query: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
            EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN
Sbjct: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540

Query: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600
            VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ
Sbjct: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600

Query: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660
            QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ
Sbjct: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660

Query: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
            VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ
Sbjct: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720

Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
            KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL
Sbjct: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900
            LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK
Sbjct: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900

Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
            SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG
Sbjct: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960

Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
            MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS
Sbjct: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020

Query: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080
            LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER
Sbjct: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080

Query: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140
            DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW
Sbjct: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140

Query: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200
            SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ
Sbjct: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200

Query: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
            TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE
Sbjct: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260

Query: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
            PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK
Sbjct: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320

Query: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
            TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380

Query: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
            DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440

Query: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
            ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500

Query: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
            YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560

Query: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
            GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620

Query: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680
            AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV
Sbjct: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680

Query: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740
            ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ
Sbjct: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740

Query: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800
            DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI
Sbjct: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800

Query: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860
            LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST
Sbjct: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860

Query: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920
            LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK
Sbjct: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920

Query: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980
            LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD
Sbjct: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980

Query: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040
            LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML
Sbjct: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040

Query: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100
            ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK
Sbjct: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100

Query: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160
            HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR
Sbjct: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160

Query: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220
            KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA
Sbjct: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220

Query: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
            IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK
Sbjct: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280

Query: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
            IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV
Sbjct: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340

Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
            IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR
Sbjct: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400

Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460
            LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA
Sbjct: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460

Query: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520
            ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL
Sbjct: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520

Query: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580
            DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA
Sbjct: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580

Query: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640
            TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE
Sbjct: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640

Query: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700
            VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR
Sbjct: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700

Query: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
            QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL
Sbjct: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
            TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820

Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880
            ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL
Sbjct: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880

Query: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940
            VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV
Sbjct: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940

Query: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
            LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN
Sbjct: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000

Query: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
            DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ
Sbjct: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060

Query: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120
            KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI
Sbjct: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
            CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE
Sbjct: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180

Query: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240
            AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL
Sbjct: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240

Query: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300
            RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI
Sbjct: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300

Query: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360
            DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA
Sbjct: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360

Query: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420
            SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD
Sbjct: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420

Query: 6421 HTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVP 6480
            HTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVP
Sbjct: 6421 HTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVP 6480

Query: 6481 PASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA 6540
            PASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA
Sbjct: 6481 PASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA 6540

Query: 6541 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6600
            QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL
Sbjct: 6541 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6600

Query: 6601 KAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSL 6660
            KAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSL
Sbjct: 6601 KAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSL 6660

Query: 6661 MQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6720
            MQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV
Sbjct: 6661 MQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6720

Query: 6721 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSF 6780
            DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSF
Sbjct: 6721 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSF 6780

Query: 6781 DEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQ 6840
            DEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQ
Sbjct: 6781 DEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQ 6840

Query: 6841 LLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT 6885
            LLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT
Sbjct: 6841 LLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT 6885


>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
            [Homo sapiens]
          Length = 6907

 Score = 1.352e+04 bits (35085), Expect = 0.0
 Identities = 6884/6908 (99%), Positives = 6884/6908 (99%), Gaps = 24/6908 (0%)

Query: 1    MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
            MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD
Sbjct: 1    MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60

Query: 61   IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
            IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN
Sbjct: 61   IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120

Query: 121  PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
            PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ
Sbjct: 121  PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180

Query: 181  MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
            MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD
Sbjct: 181  MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240

Query: 241  NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300
            NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK
Sbjct: 241  NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK 300

Query: 301  DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360
            DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD
Sbjct: 301  DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD 360

Query: 361  KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420
            KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV
Sbjct: 361  KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV 420

Query: 421  TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480
            TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL
Sbjct: 421  TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL 480

Query: 481  LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540
            LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
Sbjct: 481  LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ 540

Query: 541  KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600
            KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA
Sbjct: 541  KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA 600

Query: 601  CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660
            CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK
Sbjct: 601  CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK 660

Query: 661  LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720
            LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE
Sbjct: 661  LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE 720

Query: 721  KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780
            KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF
Sbjct: 721  KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF 780

Query: 781  DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840
            DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV
Sbjct: 781  DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV 840

Query: 841  SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
            SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV
Sbjct: 841  SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900

Query: 901  EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960
            EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI
Sbjct: 901  EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI 960

Query: 961  NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
            NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK
Sbjct: 961  NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020

Query: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
            DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE
Sbjct: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080

Query: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140
            KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD
Sbjct: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD 1140

Query: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200
            FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK
Sbjct: 1141 FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK 1200

Query: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260
            ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH
Sbjct: 1201 ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH 1260

Query: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320
            LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED
Sbjct: 1261 LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED 1320

Query: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380
            TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC
Sbjct: 1321 TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC 1380

Query: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440
            LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL
Sbjct: 1381 LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL 1440

Query: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500
            KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG
Sbjct: 1441 KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG 1500

Query: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560
            REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL
Sbjct: 1501 REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL 1560

Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
            QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA
Sbjct: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620

Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
            NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE
Sbjct: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680

Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740
            RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC
Sbjct: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC 1740

Query: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800
            HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL
Sbjct: 1741 HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL 1800

Query: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860
            ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE
Sbjct: 1801 ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE 1860

Query: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920
            CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ
Sbjct: 1861 CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ 1920

Query: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980
            EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC
Sbjct: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC 1980

Query: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040
            QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP
Sbjct: 1981 QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP 2040

Query: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100
            TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI
Sbjct: 2041 TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI 2100

Query: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
            MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE
Sbjct: 2101 MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160

Query: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220
            LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE
Sbjct: 2161 LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE 2220

Query: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280
            EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV
Sbjct: 2221 EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV 2280

Query: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340
            DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK
Sbjct: 2281 DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK 2340

Query: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400
            DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE
Sbjct: 2341 DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE 2400

Query: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460
            EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK
Sbjct: 2401 EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK 2460

Query: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
            LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC
Sbjct: 2461 LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520

Query: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK
Sbjct: 2521 VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580

Query: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
            WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI
Sbjct: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640

Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
            SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK
Sbjct: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700

Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760
            NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD
Sbjct: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD 2760

Query: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
            ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL
Sbjct: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820

Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
            KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS
Sbjct: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880

Query: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940
            QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH
Sbjct: 2881 QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH 2940

Query: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000
            KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK
Sbjct: 2941 KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK 3000

Query: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
            LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL
Sbjct: 3001 LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
            QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120

Query: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180
            LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL
Sbjct: 3121 LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL 3180

Query: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240
            EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL
Sbjct: 3181 EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL 3240

Query: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300
            NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ
Sbjct: 3241 NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ 3300

Query: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
            EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN
Sbjct: 3301 EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360

Query: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
            YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL
Sbjct: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420

Query: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480
            RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER
Sbjct: 3421 RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER 3480

Query: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
            EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN
Sbjct: 3481 EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540

Query: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600
            VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ
Sbjct: 3541 VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ 3600

Query: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660
            QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ
Sbjct: 3601 QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ 3660

Query: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
            VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ
Sbjct: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720

Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
            KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL
Sbjct: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900
            LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK
Sbjct: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK 3900

Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
            SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG
Sbjct: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960

Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
            MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS
Sbjct: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020

Query: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080
            LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER
Sbjct: 4021 LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER 4080

Query: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140
            DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW
Sbjct: 4081 DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW 4140

Query: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200
            SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ
Sbjct: 4141 SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ 4200

Query: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
            TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE
Sbjct: 4201 TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260

Query: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
            PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK
Sbjct: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320

Query: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
            TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380

Query: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
            DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440

Query: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
            ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500

Query: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
            YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560

Query: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
            GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620

Query: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680
            AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV
Sbjct: 4621 AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV 4680

Query: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740
            ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ
Sbjct: 4681 ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ 4740

Query: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800
            DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI
Sbjct: 4741 DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI 4800

Query: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860
            LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST
Sbjct: 4801 LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST 4860

Query: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920
            LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK
Sbjct: 4861 LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK 4920

Query: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980
            LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD
Sbjct: 4921 LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD 4980

Query: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040
            LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML
Sbjct: 4981 LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML 5040

Query: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100
            ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK
Sbjct: 5041 ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK 5100

Query: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160
            HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR
Sbjct: 5101 HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR 5160

Query: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220
            KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA
Sbjct: 5161 KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA 5220

Query: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
            IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK
Sbjct: 5221 IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280

Query: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
            IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV
Sbjct: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340

Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
            IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR
Sbjct: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400

Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460
            LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA
Sbjct: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA 5460

Query: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520
            ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL
Sbjct: 5461 ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL 5520

Query: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580
            DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA
Sbjct: 5521 DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA 5580

Query: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640
            TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE
Sbjct: 5581 TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE 5640

Query: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700
            VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR
Sbjct: 5641 VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR 5700

Query: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
            QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL
Sbjct: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL 5760

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
            TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820

Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880
            ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL
Sbjct: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL 5880

Query: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940
            VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV
Sbjct: 5881 VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV 5940

Query: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
            LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN
Sbjct: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000

Query: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
            DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ
Sbjct: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060

Query: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120
            KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI
Sbjct: 6061 KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI 6120

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
            CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE
Sbjct: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180

Query: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240
            AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL
Sbjct: 6181 AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL 6240

Query: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300
            RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI
Sbjct: 6241 RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI 6300

Query: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360
            DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA
Sbjct: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA 6360

Query: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420
            SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD
Sbjct: 6361 SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD 6420

Query: 6421 HTGDVGGSSSHEEDEEGPYYSAL-----------------------SGKSISDGHSWHVP 6457
            HTGDVGGSSSHEEDEEGPYYSAL                       SGKSISDGHSWHVP
Sbjct: 6421 HTGDVGGSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 6480

Query: 6458 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6517
            DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE
Sbjct: 6481 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6540

Query: 6518 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6577
            DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML
Sbjct: 6541 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6600

Query: 6578 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
            KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ
Sbjct: 6601 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6697
            LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR
Sbjct: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720

Query: 6698 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6757
            ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR
Sbjct: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780

Query: 6758 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESR 6817
            EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTEGEEETESR
Sbjct: 6781 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTEGEEETESR 6839

Query: 6818 VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLR 6877
            VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLR
Sbjct: 6840 VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLR 6899

Query: 6878 YTNGPPPT 6885
            YTNGPPPT
Sbjct: 6900 YTNGPPPT 6907


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 2247 bits (5823), Expect = 0.0
 Identities = 1816/6565 (27%), Positives = 3126/6565 (47%), Gaps = 575/6565 (8%)

Query: 733  LKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDT-----------SMEESLKHLIAKGSMFD 781
            LK  KD++K     E+   ++     Q+++++           S+  ++  LI K     
Sbjct: 2346 LKKVKDIQK-----ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400

Query: 782  ELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVS 841
            +L ++++  LQ  ++   S ES Q      L AK                AA K  +D +
Sbjct: 2401 QLCSKTQASLQESLEKHFS-ESMQEFQEWFLGAK----------------AAAKESSDRT 2443

Query: 842  PDLDI-RLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
             D  +   K+ + Q  L+S +   Q  L      G+ +  H    I+S+ +   +  KA 
Sbjct: 2444 GDSKVLEAKLHDLQNILDS-VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE--QITKAN 2500

Query: 901  EELKNNVTEDIKMSLEEKSRDVCAK----WESLHHELSLYVQQLKIDIEKGKLSDNILKL 956
            EE +  + + +K   ++++   CA     +E  H +L+L++ +++       L ++   +
Sbjct: 2501 EEFQAFLKQCLK---DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHI 2557

Query: 957  EKQINKEKK-------LIRRGRTKGLIKEHEACFSEEG---------CLYQLNHHMEVLR 1000
             ++ N+  K       L+    +   + +     SEEG         C   L  H  +LR
Sbjct: 2558 PEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLR 2617

Query: 1001 ELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTS------------ 1048
               E+L S +   +    L++  Q +   +K   +     + T G               
Sbjct: 2618 MTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDI 2677

Query: 1049 ---KNEGTITTSENRGGDPHSEAPFAKSDN---QPSTEKAMEPTMKFSLASVLRPLQEES 1102
               K EG +  +   G    +     K      Q   E   E       +SV      ES
Sbjct: 2678 LLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES 2737

Query: 1103 IMEK--DYSASINSLLERYDTYRDILEHHLQ-----NNKF----RITSDFSSEEDRSSSC 1151
            ++ +  DY    N L +  ++    +EH LQ       KF     + S  S  ED + + 
Sbjct: 2738 VISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL 2797

Query: 1152 LQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLN 1211
             +      ++ +   D  +K+     LK +   NDI            KE+ R+++  + 
Sbjct: 2798 HRLIAKSRELYEKTEDESFKDTAQEELKTQ--FNDIMT--------VAKEKMRKVEEIVK 2847

Query: 1212 TRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQ 1271
              +  L+        V + +  L  +   LH+ +          +    ++ + DS    
Sbjct: 2848 DHLMYLDA-------VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIG 2900

Query: 1272 IEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLAS 1331
                +R+E     V +         M   +   +  ++     V +++  L+ L   +A 
Sbjct: 2901 ASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA- 2959

Query: 1332 LRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD------KCLKMLD 1385
                 LS +  +   A   Q  ++ +  +K    ++ L++ K    +      K  ++LD
Sbjct: 2960 -----LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILD 3014

Query: 1386 MSFKDAERGDDTSCE-NLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQ 1444
               K   R +D   + N L  FS  LS T+   V     E N L   C+  +       Q
Sbjct: 3015 ALQKAEPRTEDLKSQLNELCRFSRDLS-TYSGKVSGLIKEYNCL---CLQASKGCQNKEQ 3070

Query: 1445 DVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT 1504
             +Q +  K         A +  ++ L+       +  +  +++ E++ SL   ++   ++
Sbjct: 3071 ILQQRFRK---------AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3121

Query: 1505 VNQQCQNTVVLWENTKALVTECLEQC-GRVLELLKQYQNFKSILTTLIQKEESVISLQAS 1563
             N Q +  ++L +          E+  G   ++    +++K+  + L QKE ++      
Sbjct: 3122 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESAL------ 3175

Query: 1564 YMGKENLKKRIAEIEIVKEEFNEHLEVVDK---------------------INQVCKNLQ 1602
                ENLK ++ + E+  E   + L   +K                     +  V + + 
Sbjct: 3176 ----ENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIH 3231

Query: 1603 FY---LNKMKTFEEPPFEKEA---------NIIVDRWLDINEKTEDYYENLGRALALWDK 1650
             Y   LN++K   +  +E +A         + +  ++L ++  T++    L R +A  ++
Sbjct: 3232 CYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQ 3291

Query: 1651 LFNLKNVIDEWTEKALQKMELHQLTEEDRE-------RLKEELQVHEQKTSEFSRRVAEI 1703
                   + +W   A+  ++ +     D+        +L+  L V ++K  +    V   
Sbjct: 3292 FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRG 3351

Query: 1704 QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA-LSGSTAELREDLDQAKTQIG 1762
            + +LQ++  P  +  ++  + +  +     L+    C + L G+ ++     D  +   G
Sbjct: 3352 ESVLQNTS-PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3410

Query: 1763 MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS 1822
              +S+   L+ S          E Q   L+ K +M+            L+E    Y S+ 
Sbjct: 3411 WMDSMEANLNES----------ERQHAELRDKTTMLGKAKL-------LNEEVLSYSSLL 3453

Query: 1823 DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQ------ 1876
            +    K + + +H+   L  + ++  + +  I+   KE    SE    + Q+ Q      
Sbjct: 3454 ETIEVKGAGMTEHYVTQL--ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAF 3511

Query: 1877 ---------KLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKM 1927
                     KL  +  LEG     +     L+ ++ H  +     L S L  +E  +   
Sbjct: 3512 EVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL-LNSVLHTREDVIPS- 3569

Query: 1928 ESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKR 1987
              I QA  + LE   Q     Q      R    N   K + ME+  ++ + + +  A ++
Sbjct: 3570 -GIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKT-AEEK 3627

Query: 1988 EQFESVAQLNNSLKEYGFTEEE---------EIIMEATCLMDRYQTLLRQLSE----IEE 2034
            +  E V    + ++E G   +E          +  +AT L  RYQ LL Q+ E    +EE
Sbjct: 3628 KWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEE 3687

Query: 2035 EDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI-ILLKP-- 2091
            E + L   + S +  +     W     ++   + +   K+      +K+K + +LLK   
Sbjct: 3688 EIQSLEESESSLSSYSD----WYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3743

Query: 2092 EGDARI-------ETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEG 2144
            +G + +       E  +K  E  EA  ++K + D   Q               EK L   
Sbjct: 3744 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3803

Query: 2145 EKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKS 2204
            +++    + L   + E ++        +  L EKKAQL  YK   +        +K ++ 
Sbjct: 3804 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVRE 3863

Query: 2205 QGNYLLECTKNPSFSEE------PWLEIKHLHESLLQQL---QDSVQNLDGHVREHDSYQ 2255
            +G  LLE  ++ +  ++       + ++  + +++++++   +D + NL   ++      
Sbjct: 3864 KGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQ--MKGDTLIG 3921

Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIA--VEEKLQKLQ-ELENRLSLQDGTLKKILAL 2312
             C   L   L       +  +      I    +   Q L+ EL+  +S QD TL++  A 
Sbjct: 3922 QCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQD-TLQQCQAW 3980

Query: 2313 AKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGK 2372
              +V+ +     Q  +       Q K        A    ++ C +  +  +   T  K  
Sbjct: 3981 LSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAK-- 4038

Query: 2373 FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTED 2432
                  + Q T    E  Q+    + L + WE  K    E+ +  Q +    ++MK    
Sbjct: 4039 ------DIQQTEQTIE--QKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4090

Query: 2433 ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPL-EQTECLNKTETGALVL 2491
            E ++N  QN             + +++    +L++K+A++  + E+   L K E      
Sbjct: 4091 ELELNIAQNM------------VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHK 4138

Query: 2492 HNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
                 + Q LD L +    L   +E      RD+ + +  VE  ++   T+ ++L     
Sbjct: 4139 EINHLNDQWLD-LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA 4197

Query: 2552 DSVT-YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQV 2610
            +S   +L+ +KK   ++++ K ++ +LK + + +  H+   DK+L++ Q   LE  W Q+
Sbjct: 4198 ESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL 4257

Query: 2611 EQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS--PEERAGNQSM--I 2666
            E  I++K    V   +E   + ++ Q+     ++QQ ++   LK   P + A N  M  +
Sbjct: 4258 EDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHL 4317

Query: 2667 ALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQ 2726
            A+ ++L+A +     L   A+  M  + G  E++ ++  +++ +     L  L  +    
Sbjct: 4318 AICSELEAKQMLLKSLIKDADRVMADL-GLNERQVIQKALSDAQSHVNCLSDLVGQRRKY 4376

Query: 2727 IKKC-DIRNKMKETILWAKNLLGE------LNPSIPLLPDDILSQIRKCKVTHDGILARQ 2779
            + K    + +    +  A + + +          I LLPDD+  Q++ CK     +   Q
Sbjct: 4377 LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ 4436

Query: 2780 QSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNF 2839
              V  L  + ++ +  +T  E S++   L++L++ Y  ++ K + R Q+LE  L  R +F
Sbjct: 4437 NEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHF 4496

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELT 2899
                 K    +++++ +  P +      +EL       +   ++  E ++ + T  +   
Sbjct: 4497 KEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQ 4556

Query: 2900 NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEA 2959
             I   LN  +  +L ++L  L  + N I    ++   +V+  I   +++        +  
Sbjct: 4557 TILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSL 4616

Query: 2960 DSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKC-------CILQVLKLKKVFDYIGLNW 3012
              ++   L +++       EE  +L+D   AI          + ++ + K+ F   G  W
Sbjct: 4617 SELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPW 4676

Query: 3013 DFSQLDQLQTQVFEKEKELEEKIKQLD----TFEEEHGKYQALLSKMRAIDLQIKKMTEV 3068
               ++  L T     +++ E+++  L+     ++E     Q L  +++++  +  K+ E 
Sbjct: 4677 QPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE 4736

Query: 3069 VLKAPDSSPESRRLNAQILSQRI--EKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLN 3126
             L A +       L   +    I  ++     +++   L      D    EK   QI+  
Sbjct: 4737 TLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHL------DPLAYEKARHQIQSW 4790

Query: 3127 AEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQ 3186
              E   L   +   V E   + +   + Q ++  SL  L ++K++L  P+ ++L ++ IQ
Sbjct: 4791 QGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQ 4850

Query: 3187 NEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE--ASDVETKLREFEDLQMQLNTSI 3244
             E    +  QE+V + +  + A++  EK++   + E  ++D+E  L E  +L   +  ++
Sbjct: 4851 EEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL 4910

Query: 3245 DLRTNVLNDAYENLTRYKEAVTRAVESITSLEAII--IPYRVDVGNPEESLEMPLR---K 3299
              R   L + Y    RY +    A + +   + ++      +DV + EE+L+  +     
Sbjct: 4911 RTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFST 4970

Query: 3300 QEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLE 3359
            +++  S +  +  L   L  +  P  K  L+  +  L  ++  M     AQ    +R   
Sbjct: 4971 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTA 5030

Query: 3360 NYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
             +  Y+K  E++   ++  E  L +       S  EA E+L + KALVS + S  E+++ 
Sbjct: 5031 QWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVA 5090

Query: 3420 LRQILRLLRLRCTENDG--ICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEE 3477
            L +  +  +L  T ND     L + ++ +W++W  L   A++ E   E+   EW   + +
Sbjct: 5091 LEE--KASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148

Query: 3478 IEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRS 3537
            +++   ++D LQ++LP    + E A+  EL  LL+    +   +E+QQ  L +L Q+  S
Sbjct: 5149 VKKATEMIDQLQDKLP--GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLS 5206

Query: 3538 IQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKN 3597
            +     +    E  P  QEIT+M++RC  + +KV+ N +LV+ E+++R     +I ++K 
Sbjct: 5207 MLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKC 5266

Query: 3598 FFQQTTTSFQNMAFQ----------------DHPEKSEQFEELQSILKKGKLTF------ 3635
            + Q+T     N   +                +H +  E+  E Q     G  T       
Sbjct: 5267 WVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELS 5326

Query: 3636 -------------ENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKIS----NE 3678
                         + I +K  IK  E       E+  Q+++  K L  I  K+     N 
Sbjct: 5327 LQLAEVALDLKIRDQIQDK--IKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNV 5384

Query: 3679 VLKSSPSYAMRRKIEEINNGLHN----VEKMLQQK-------SKNIEKAQEIQKKMWDEL 3727
            V   +    +  +++  N+ L      V+K L+Q        +K I K  E+ ++   + 
Sbjct: 5385 VQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQA 5444

Query: 3728 DLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKM 3787
            +   SKLN+  S +++  E       +W++   +        +  ++ R   +   T+ +
Sbjct: 5445 ENRLSKLNQAASHLEEYNEMLE-LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL-L 5502

Query: 3788 EEYSDLLKSTEAWIENTSHLLA-------NPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            EE  ++    EA  E   +L +       +    +  R        +++ L++ +     
Sbjct: 5503 EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD 5562

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQE-----LSNQVTALQQKI--MESL-PQIQ------ 3886
            +     +L+ L    E  + T +  E     L  Q++  Q  +  MESL P++Q      
Sbjct: 5563 MKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ 5622

Query: 3887 ---RMADDVVA----------IESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVI 3933
               R+ +DVVA          ++ E   ++    +   I+ +  +     E+ +KH + +
Sbjct: 5623 SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQL 5682

Query: 3934 LE--------------NIRPMKKTIA-------EIVSYQVELRLPQTGMKPLPVFQRTNQ 3972
            +E              NI+ ++  I+       +I  YQ ++    +  K L +  +   
Sbjct: 5683 IEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT 5742

Query: 3973 LLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIEN--------LKQILNNYSAQFSLEHM 4024
            +L  +  +E + +   +L   ++   +     +          L  +      + +   +
Sbjct: 5743 MLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI 5802

Query: 4025 SPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLP 4084
            S   A + P      +    Q ++  Q        L+     +H      QE  E    P
Sbjct: 5803 SSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAAKIHPSTSASQEFYEPGLEP 5860

Query: 4085 AVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQ 4138
            + T++ G +       +   SE++     ++      ++ ++  S K +  + K   SP+
Sbjct: 5861 SATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE 5920

Query: 4139 SWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRP 4198
               S    +  M E +A      ++Q+   +I+   +S+A+ L  +S   +   + +L+ 
Sbjct: 5921 PGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAEELVSESCEADPAEQLALQS 5974

Query: 4199 NQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQA 4255
              T   E  +T  ++A        +  L  ++E+ R E  + L   + +  EL+ WL   
Sbjct: 5975 TLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--QALQRYRCEADELDSWLLST 6031

Query: 4256 NVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETC---KDQGLGDNGATQHEA 4312
               ++           +E QL+ CQ ML EIE KV  L E     ++  L     T+ EA
Sbjct: 6032 KATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEA 6091

Query: 4313 EALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTE 4372
            E L+ KL+ +K +L ++Q  L +K    Q     K+ S+ +      P     L    T 
Sbjct: 6092 EQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTT 6151

Query: 4373 RPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASS 4432
              Q  RQ   QQQ+ LE +  EQK  ++ +    +++  Q+   +  T+ ++       S
Sbjct: 6152 WTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAE--TSGDAGEKPDVLS 6208

Query: 4433 PENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQ----VSTNMGILPSVTMY 4488
             E  +     S + Q   KW+ LH E S+K KL    L + Q     S    +L  V +Y
Sbjct: 6209 QELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLY 6268

Query: 4489 NFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVE 4548
                PT ++    T+ L+ L Q    + +Q    +   I+L++KL++     S  L  VE
Sbjct: 6269 KGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVE 6327

Query: 4549 EMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECF 4607
            E L +   L  E+      + E LA ++K++   +   K    +A    G+N +++ +  
Sbjct: 6328 ERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTL 6387

Query: 4608 DNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQS 4667
              L   L    +    R   +K  L    ++QN++K L+  L  +K  + Q L  +  Q 
Sbjct: 6388 GCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP 6447

Query: 4668 VAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARY 4727
            VAEQ++        L+  ++ + +L+  G++L +    +QE+ KL+D+ D +  ++ +R 
Sbjct: 6448 VAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRR 6507

Query: 4728 TELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV 4787
            + L+     +SQ +  LQ + +L++ G+EK+A        SK  +Q  ++ HK +FQ L 
Sbjct: 6508 SGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE 6567

Query: 4788 ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENY 4847
            + M+L +    KI+   +Q    F  E + +   + +++ + G++L+ +L+ W   DE+ 
Sbjct: 6568 SHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6627

Query: 4848 ASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA 4907
              L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++     +LYQ L++GK+L+ 
Sbjct: 6628 QELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 6687

Query: 4908 SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTL 4967
            S+SC +LE Q+ +L E WLS   K+  ELHRL+ +LKH   Y  +S  L  WL+S++  L
Sbjct: 6688 SISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL 6747

Query: 4968 NYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLR 5027
             +W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V+S GNQLL LK+ DTATLR
Sbjct: 6748 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6807

Query: 5028 ASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS-DEDSVH 5086
            + L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E++SW++ +E+    DED++ 
Sbjct: 6808 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIK 6867

Query: 5087 SPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGE 5146
            +      +   LQK+K F+++++ KQ  VDFVNQS+LQ+S+ DVESKR ++T+FAE LG 
Sbjct: 6868 NSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGA 6927

Query: 5147 MNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQ 5206
            MN+ W  + G++  KIQ LE LLES +E EN +Q L  W E QE+RLK   +     SVQ
Sbjct: 6928 MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQ 6987

Query: 5207 KLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLEDTASRIDELFQKRSSVLTQV 5265
              L DCQD+E+ +  K K +++++Q+ L L ++    +     S + EL Q  +++   V
Sbjct: 6988 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7047

Query: 5266 NQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQD 5325
             QLK  ++SVL +W  +   +D++N   +   Y +   + +  SLE ++ QV+NLQ+LQD
Sbjct: 7048 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQD 7107

Query: 5326 EAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLL 5384
            + E  E S +K   +  +L   C P V E +    +  + RW  + + IA+QLQ +++LL
Sbjct: 7108 DLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALL 7167

Query: 5385 QLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKE 5444
            QLW+ Y +   + A+ ++QQE +  +L   + + +   + +   +QD  +L   +   K+
Sbjct: 7168 QLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKD 7227

Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFG 5503
            +      + ++L Q  ++S    +     SL Q    LE+ L  +    +  +  ++ F 
Sbjct: 7228 SLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFA 7287

Query: 5504 VRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNHVLALTAQSPDIEHLNEVSL 5556
              LE+L+  I+  EE L   D  H  +    +E  +     +L  ++ +PD++ LNE+  
Sbjct: 7288 KSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGY 7347

Query: 5557 KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEA 5615
            +LPL+D  +K +QN+NR W   ++   ER S+LQ   L ++ FL  CE W++ L + E+ 
Sbjct: 7348 RLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK 7407

Query: 5616 LKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFS 5675
            L V+++ +   LLEQQ+ +++ +AE+   Q I  S +    +LL+  ++++R EF  + +
Sbjct: 7408 LAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLT 7467

Query: 5676 KLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLY 5735
             L+++WQ  ++  +QR+G +D  +RQWQ +    E L ++L + S+L  +  G     L 
Sbjct: 7468 LLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ 7527

Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
            Q R+L  E++ KE  F R++ +  LT+EAG++LLL+ D   + ++   ++++Q+ WK   
Sbjct: 7528 QARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSAS 7587

Query: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE 5855
             +L E  K+    ++ W++CEK I +   +L+  K +    LP+ HE+LH E+   KELE
Sbjct: 7588 MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7647

Query: 5856 QSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDR 5915
             ++ SWT +L +L  +K  L+ ++  +D+ +L E++E L RQWE+LC ++++R+Q+I +R
Sbjct: 7648 NAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGER 7707

Query: 5916 LNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQ 5975
            LN W VF+EKNKELC WL QME+KV Q  DI IEEMIEKL+KD  EEI +  ENK+QL+Q
Sbjct: 7708 LNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ 7767

Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
            MG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET   +QQLDKNMS+LR
Sbjct: 7768 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 7827

Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
            TWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD D
Sbjct: 7828 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 7887

Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
            ACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+
Sbjct: 7888 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 7947

Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRL 6215
            ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A  L
Sbjct: 7948 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8007

Query: 6216 KQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFS 6275
            KQMVHEGNQRWDNLQ+RVT++LRRL+HF  QREEFE  R+SILVWLTEMDLQLTN+EHFS
Sbjct: 8008 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8067

Query: 6276 ESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
            E D   K++QL  FQQEI+LN NKI+Q+I  GEQLI+KSEPLDA +IE+EL+EL RYCQE
Sbjct: 8068 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8127

Query: 6336 VFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQ 6391
            VFGRV R+H++L    P  +DE + S+ E ++ED   +    W  R      S +PSS  
Sbjct: 8128 VFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 8186

Query: 6392 SLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG-------GSSSHEEDEEGPYYSALS 6444
            SL        ERSG +TP SVDSIPLEWDH  D+          +   EDEEG       
Sbjct: 8187 SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246

Query: 6445 GKSISDGHSWHVPDSPSC----PEHHYKQMEGD--------------------------- 6473
             +         +P+SP       E+  K   GD                           
Sbjct: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 8306

Query: 6474 --RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE----- 6526
              R+  P  P   T YK   G + L        +  + L    ++E+  L G        
Sbjct: 8307 IIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 8363

Query: 6527 -QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP 6582
             Q +G  DRWE++QAQ L  +L++KQNL   QQ NSD+++I  WL  TE ELE L+  + 
Sbjct: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8423

Query: 6583 PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 6642
             +DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q++  W
Sbjct: 8424 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 8483

Query: 6643 EAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 6702
            +     ++ WRG L+ +LMQCQ FH++S  LLL L +   R+ +    D   D   L + 
Sbjct: 8484 DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 8543

Query: 6703 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS- 6761
             ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L ++VS 
Sbjct: 8544 HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 8603

Query: 6762 -----QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA---------- 6804
                 + L+ +  +Q   S   S DE+D SG   P +    P R K  R           
Sbjct: 8604 HIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPS 8663

Query: 6805 -----VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEED 6859
                  R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P SEED
Sbjct: 8664 VSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEED 8723

Query: 6860 YSCTQANNFARSFYPMLRYTNGPPP 6884
            YSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 8724 YSCALSNNFARSFHPMLRYTNGPPP 8748



 Score =  597 bits (1538), Expect = e-169
 Identities = 1215/5875 (20%), Positives = 2344/5875 (39%), Gaps = 933/5875 (15%)

Query: 25   LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
            LQ EQE  QK+ FT WINS LA+   P V+ DLF D+K G  LL LLEVLSGQ+LP ++G
Sbjct: 21   LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80

Query: 85   SNTFQCRI--NIEHALTFLRNRS-------IKLINIHVTDIIDGNPSIILGLIWTIILHF 135
                +     NI  AL FL  R        IKL+NI+ TDI DG PSI+LGL+WTIIL+F
Sbjct: 81   RRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYF 140

Query: 136  HIEKLAQTL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQ 194
             IE+L   L        S   V  + SS   SPP+K+  KV  + Q +A+KALL W Q  
Sbjct: 141  QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYT 198

Query: 195  CATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELK 254
                  + V DF  SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL 
Sbjct: 199  AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 258

Query: 255  IPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK---- 310
            IPRLL+PEDVDV  PDEKSIMTYVAQFL++  D      + Q   +   G+ +       
Sbjct: 259  IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQN 318

Query: 311  ---------EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSI 352
                     ++++  ++  E D             KY S   F   +  ++K    ++  
Sbjct: 319  FKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQP 378

Query: 353  KRDLDELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSA 412
                 +L  D   ++++WD +  ++  W I+L+ +LP PL    AWL   E  + E+++ 
Sbjct: 379  LHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITV 438

Query: 413  SQDHSQAVTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRIN 471
             Q H +    IQ K+   K L+   + H       +  +  N +P VPP++LE+M  R +
Sbjct: 439  QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFH 497

Query: 472  NI--LEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEK 529
             +    +  ++ +EF   K  +L L+   +SKL  W IKYG RESVE LL+++  FIE  
Sbjct: 498  FVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENS 557

Query: 530  EFLARLDTSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQK 583
            +F  + + ++Q   +  E+Y    G  +        +      +R     + +V+S L++
Sbjct: 558  KFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEE 617

Query: 584  VLACWATYVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEV 638
            V++ W  Y   +  L+A  E+ +K     E  K+  F  L  W  +H  +N+AGNFL+E 
Sbjct: 618  VISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIET 677

Query: 639  SNDVVGSSISKELRRLNKRWRKLVSKTQ-------------------------------- 666
             +++V   + ++L  LN RWR+L  + +                                
Sbjct: 678  CDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKK 737

Query: 667  ----LE---MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQ 714
                LE   MN+ L+I+     +Q  P  D    I++K      + S     E  E +  
Sbjct: 738  LSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFAT 795

Query: 715  NIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESL 770
              K  E+  K  E ++  L    + ++L+  +E  E +  S  D     +++ T +E   
Sbjct: 796  MSKLKEQLTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREA 852

Query: 771  KHLIAKGSMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQ 824
            +          EL+A  E+      +++   Q++    +  +VL    Q ++Q     + 
Sbjct: 853  QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 912

Query: 825  I---NVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKH 881
            +   ++VK     K    V  +  +  K EES+ ELE  +  AQ+ L ++  P EL+ +H
Sbjct: 913  VAFQSMVKKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRH 970

Query: 882  KEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLK 941
             E     + + L  +LKA +EL + + E  +  L+E  R +  +W+ L  E   ++  LK
Sbjct: 971  TEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1030

Query: 942  IDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRE 1001
            ID+EK +   ++ +   ++++E KL+ +  ++ +IKEH   FS++G  +     ++++ E
Sbjct: 1031 IDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090

Query: 1002 LCEELPSQKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTS 1057
            LC +LP +   ++        LK+    I+   +   E     +      S+    I+T+
Sbjct: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTN 1150

Query: 1058 ENRGGDPHSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIME 1105
            E +      EA    + N    ++A+E           T+ +  S   VL  +  E+  +
Sbjct: 1151 ETQLKGIKGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ 1208

Query: 1106 K--DYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIK 1163
            K  D  A ++S  +   T    +E  L N                  C+Q K    +++K
Sbjct: 1209 KQGDELAKLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVK 1249

Query: 1164 NETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRL 1223
            N  +      E+IS                      KE + + +  L+T  E+L  A +L
Sbjct: 1250 NSLE------ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQL 1281

Query: 1224 VLPVEKASLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEP 1281
            +L  ++ +  +      + +   Q         DR ++ LR ++ ++        R E  
Sbjct: 1282 LLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERR 1341

Query: 1282 GNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEP 1341
                L++   F+ +  +  +++Y  Q  G +H    S  +L++L   L   +      E 
Sbjct: 1342 IQVTLRKWERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1398

Query: 1342 VTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCEN 1401
            +   + +  + A E  L  +NK+    L++ +AK + + +K L          +DT  E+
Sbjct: 1399 IAVQAENLVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEED 1444

Query: 1402 LLDAFSIKLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLK 1456
            +     +K    H +G   E      TE+ K L       N L  +   +  QIS+I + 
Sbjct: 1445 IKTMEMVKTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV- 1495

Query: 1457 DPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLW 1516
              T+  ++ +  S++               L+E A S   F    E    +     +  +
Sbjct: 1496 --TIQEIESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRY 1539

Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
                    +CLE  G +L  L Q Q F+  L  +   ++SV   +        +     E
Sbjct: 1540 GEELREHAQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATE 1594

Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTED 1636
               V +E  +  + ++ ++       F  +  K        +EA  +  ++ DI  + ++
Sbjct: 1595 TYKVLQEHMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1652

Query: 1637 YYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSE 1695
                L   LA W +L    +    W E+   K    ++    DR +++ ELQ+ +   +E
Sbjct: 1653 RQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE 1712

Query: 1696 FSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLD 1755
               + +    LLQ  E    +   +   + K+ H+++                E   DL 
Sbjct: 1713 VVSQASFYSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLP 1757

Query: 1756 Q-AKTQIGMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSE 1813
            Q    +I   +S++      D L + F+   ++    LQ    + ++++Q+         
Sbjct: 1758 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA-------- 1809

Query: 1814 LKKQYESVSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
            L +  +  +++ + K  +  LQ H +KL         D    ++   ++CF+  E    V
Sbjct: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQV 1866

Query: 1872 EQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESIC 1931
             ++ Q     L                + ++ H   + +   +   V     + K ES  
Sbjct: 1867 VERRQLALSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES-- 1909

Query: 1932 QARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQF 1990
                K+L D+LQ    L+    +L   L+  +   K G  E           L  + E+ 
Sbjct: 1910 DLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERI 1969

Query: 1991 ESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            +++     S       E + + +      D+ + LL+ + +IEE      T+ +   +  
Sbjct: 1970 QNLLGTKQS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPT 2017

Query: 2051 HDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAP 2110
                   + +++ L V N  E ++   E      E+  LK +        + Q + + AP
Sbjct: 2018 R------QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAP 2061

Query: 2111 LVQKTLTDISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
             V + +  +   WD+T  L              +   + L     K L++   + +    
Sbjct: 2062 EVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT 2121

Query: 2161 LKKKQEAGFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPS 2217
            +K +++  +A  +H   + K   + K    F  K + L S LK++ S    L++     +
Sbjct: 2122 IKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMEST 2181

Query: 2218 FSEEPWLEI-KHLHESL---------------------------LQQLQDSVQNLDGHVR 2249
               + WL++ + L E++                           + Q+ +++ NLD H+R
Sbjct: 2182 V--DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLR 2239

Query: 2250 ----------EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRL 2299
                      E  +  + + +L++ +++  +   +    P  Q    + +QKL+  +   
Sbjct: 2240 AEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299

Query: 2300 SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASA 2349
             +  GTLK   A +  V++  + +     K +   + C Q          KD++  L S 
Sbjct: 2300 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQ 2359

Query: 2350 KQEMECC---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDW 2403
            +  +      LNS+ +   S E +      T   ++ +A S +   TQ S   E LE+ +
Sbjct: 2360 QSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHF 2418

Query: 2404 EINKDSAVEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ----- 2454
              +     E  +  + +  A+ES   T D    E K+++LQN    LD++   +      
Sbjct: 2419 SESMQEFQEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAV 2473

Query: 2455 LEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKN 2514
             +E + LY  L  +   I    Q +     E     L       Q L +    L + +  
Sbjct: 2474 TQEGQTLYAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQ 2530

Query: 2515 KESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSL 2574
                   + + +E       + + L   K+ +     +    + K++ F+  +   ++SL
Sbjct: 2531 HRKLNLWIHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESL 2581

Query: 2575 GNLKIKWENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLM 2632
              L  + + LS   H    + +L      QL    + + +  ++K     V   E   L 
Sbjct: 2582 DKLSQRGQLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALE 2637

Query: 2633 NKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKR 2692
              +Q    S+    + +Q RL   E   G++  +       +      ++KG+ E+++  
Sbjct: 2638 EALQ----SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNM 2690

Query: 2693 IWGEKE---KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGE 2749
              G+ E   + + ++G   ++ Q ETL+                       +WA  +   
Sbjct: 2691 AIGKGEQALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSS 2728

Query: 2750 LNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDL 2804
            ++    L  + ++SQ        +  + R+  +E   E V  K+     P     E   L
Sbjct: 2729 VHAQSTL--ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL 2779

Query: 2805 NNTLEDLRNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRV 2861
             + L+ + ++   +   + +   +S++L  K E+ S  F    + +L  Q ++ + + + 
Sbjct: 2780 LDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKE 2837

Query: 2862 ETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKN 2919
            +    E  +K H + L+A  +    + S     L   +++  + +  ++    +++ + +
Sbjct: 2838 KMRKVEEIVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDS 2896

Query: 2920 LKIRTNRIQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEV 2973
             +I  +R+ R +++   EV+       C   H +  AL+ +     DS+ + +  L   V
Sbjct: 2897 REIGASRLSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV 2955

Query: 2974 NKGVKEE------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQ 3019
            ++    E      +  L+  L      +      L +L+ K   + I   W   Q  LD 
Sbjct: 2956 SQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDA 3015

Query: 3020 LQTQVFEKEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAP 3073
            LQ +   + ++L+ ++ +L  F  +     GK   L+ +   + LQ  K    +  +   
Sbjct: 3016 LQ-KAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQ 3074

Query: 3074 DSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKL 3133
                  R     +++ +I  AKC   +I + ++E  T     K +E L    N +    +
Sbjct: 3075 RFRKAFRDFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNM 3130

Query: 3134 YKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDN 3191
                  ++  L  KE   K  Q K+  +        S L Q    L NL+I+ +++ + +
Sbjct: 3131 MLSKGELLSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVS 3188

Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
             E  Q+  W        ++  EK   E+S+   D+  K RE + LQ  L           
Sbjct: 3189 AEPIQD--W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI-------- 3230

Query: 3252 NDAYE-NLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI 3310
               YE  L R KE   +  E   + ++                     +  +L S    +
Sbjct: 3231 -HCYEPQLNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLAL 3271

Query: 3311 QDLT-EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRK 3366
             +LT EK+               L  +V++++      K  +   T+A   L++Y C+  
Sbjct: 3272 SNLTKEKVS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPT 3317

Query: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
             ++ +  +             +L L   EAL  ++Q K +   +I T+ E +        
Sbjct: 3318 SDKSVLDS------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV-------- 3354

Query: 3427 LRLRCTENDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
              L+ T  +GI  + + + ++ + W SLL A    +   E    +W    + + + +  +
Sbjct: 3355 --LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWM 3412

Query: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
            D+++  L E        +  + +EL D     G    K +LL   +L     ++ + E  
Sbjct: 3413 DSMEANLNE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVK 3459

Query: 3546 GAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTS 3605
            GA  T      +T ++      LQ +Q+    +Q   +E  + +++++ L   +Q+   +
Sbjct: 3460 GAGMTE---HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA 3510

Query: 3606 FQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
            F+    Q+  EK +Q+  L+      + T  ++ E L++  +E   ++ + + ++ +   
Sbjct: 3511 FEVWLGQEQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIP 3568

Query: 3666 KALEDIDEKISNEVLKSSPSY-----AMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
              +   +++    + +   +Y       R +   + N L  +E+  QQ  + ++ A+E  
Sbjct: 3569 SGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-- 3626

Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
            KK  +E+  +  ++ E+ +  Q+I+++    ++       +   +YQ +  +   +   L
Sbjct: 3627 KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQALLLQVLEQIKFL 3685

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHASTVQMALEDSEQK 3837
             +    +EE    L S   W  +T     N A   D + T  +     T+++ L+D E+ 
Sbjct: 3686 EEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKG 3745

Query: 3838 HNLLHS----------IFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQR 3887
            H+LL S             + E   +  E  +  + ++EL++ V      + + L   + 
Sbjct: 3746 HSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKE 3805

Query: 3888 MADDVVAI---------------ESEVKSMEKRVSKIKTILLSKEIFDFSP--EEHLKHG 3930
             +D   A+               E +++  EK+    K   L + +    P  +   + G
Sbjct: 3806 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3865

Query: 3931 EVILENIR--PMKKTIAEIVS-YQVELRLPQTGMKPLPVFQ-RTNQLLQ----------- 3975
            E +LE ++   +K  I ++ S YQ    + +  M+ +  F+ R N L             
Sbjct: 3866 EALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCAD 3925

Query: 3976 --DIKLLENV---TQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEH----MSP 4026
                KL +NV    Q   +    +        + +E+  ++  + S Q +L+     +S 
Sbjct: 3926 HLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH--ELQKHVSRQDTLQQCQAWLSA 3983

Query: 4027 DQADKLPQLQGEIERME--KQILSLNQRKE------DLLVDL----KATVLNLHQHLKQE 4074
             Q D  P  Q  + R E  KQ+      +E      DLL  +     A+V    + ++Q 
Sbjct: 3984 VQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQT 4043

Query: 4075 QEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
            ++ +E+  + A    +G        E K  +     YL   +++++  ++K  + + +  
Sbjct: 4044 EQTIEQKLVQAQNLTQGW------EEIKHLKSELWIYLQDADQQLQ--NMKRRHSELELN 4095

Query: 4135 PSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC 4194
             +    S +    K ++  +AS ++   + E   K++  + S  +    + LN +    C
Sbjct: 4096 IAQNMVSQVKDFVKKLQSKQASVNT---IIEKVNKLTKKEES-PEHKEINHLNDQWLDLC 4151

Query: 4195 SLRPN---QTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA----- 4246
                N   Q EE         T D  D    +E  +EK   E   +  +     A     
Sbjct: 4152 RQSNNLCLQREEDL-----QRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEA 4206

Query: 4247 --ELELWLQQANVAVEP---------ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLE 4295
              +L L LQ+   A+E          E LN D ++++++Q    +    ++E        
Sbjct: 4207 LKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE-------- 4258

Query: 4296 TCKDQGLGDNGATQHEAEALSLKLKTVKCNLEK---VQMMLQE--KHSEDQHPTI---LK 4347
                             + +  K++    NLE+   VQ   QE  + +E+Q P I   LK
Sbjct: 4259 -----------------DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4301

Query: 4348 KSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAK 4407
            +S  P+  + L    L +  +I +E               LE K M  K  IK    +A 
Sbjct: 4302 QSPPPDMAQNL----LMDHLAICSE---------------LEAKQMLLKSLIK----DAD 4338

Query: 4408 KMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPL 4467
            ++      ++    Q+  A + A S  N + D +       G + +YL+  LS K +  +
Sbjct: 4339 RVMADLGLNERQVIQK--ALSDAQSHVNCLSDLV-------GQRRKYLNKALSEKTQFLM 4389

Query: 4468 P--------QLVEPQV--STNMGILPSVTMYNFRYPTTEE--LKTYTTQLEDLRQEASNL 4515
                     Q  E ++    ++ +LP       +   + +  LKTY  ++  L  +   L
Sbjct: 4390 AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGREL 4449

Query: 4516 QTQENMTEEAYINLDKKLFEL----FLTLSQC---LSSVEEMLEMPRLYREDGSGQQVHY 4568
               + +TE+    +  KL EL       L +C   L  +E+ L   + ++ED   +  H+
Sbjct: 4450 --MKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKED-FDKACHW 4506

Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLEC--FDNLQVCLEHTQAAAVCRSK 4626
               A  +    + L ++  +L    T   +  N+L +   ++NL + L+ T    +    
Sbjct: 4507 LKQADIVTFPEINLMNESSEL---HTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563

Query: 4627 SLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNE--ISGQSVAEQLQKADAYTVELEN 4684
             +     Y     N + R ++ ++         + E  ++ +  A  ++       ELE 
Sbjct: 4564 EVDH--SYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621

Query: 4685 AESRVAKLRDE---GERLHLP---YALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTES 4738
               R++K+  +    E L L     A+L EV  L + +D +    +  +     P+  + 
Sbjct: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL-NQKKEGFRSTGQPWQPDK 4680

Query: 4739 QQDALLQGMVELVKIGKEKLAHGHLKQTKSKVAL----QAQIENHKVFFQKLVADMLLIQ 4794
                    M+ LV      L H   +QT+ +V+L     +  + H+   Q+L   +  ++
Sbjct: 4681 --------MLHLV-----TLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4727

Query: 4795 AYSAKILPSLLQNRETFWAEQVTEV-KILEEKSRQCGMKLQSLL------------QKWE 4841
               +K+      N ET  AE+  ++   L    +  G+ L+ +               +E
Sbjct: 4728 EEQSKV------NEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4781

Query: 4842 EFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNE 4901
            +      S + +L++L S +     V E E R+V+ I F  ++ R++     R+   L+ 
Sbjct: 4782 KARHQIQSWQGELKLLTSAIGET--VTECESRMVQSIDFQTEMSRSLDWLR-RVKAELSG 4838

Query: 4902 GKQLVASVSCPELEGQIAKL----EEQWLSL----------NKKIDHELHRLQALLKHLL 4947
               L   ++  +++ +I K+    EE   SL           +K       + A L+H L
Sbjct: 4839 PVYL--DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSL 4896

Query: 4948 SYNRDSD-QLTKWLESSQHTL-----------------NYWKEQSLNVSQ------DLDT 4983
            +   + D  + + L + Q TL                 N W E +  + Q      D+++
Sbjct: 4897 AELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVES 4956

Query: 4984 IRSNINNFFEFSKEVDE-KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLIT 5042
               N+ +  EF    D+  S+L+     +      +K T    L   +A  E +   +  
Sbjct: 4957 AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSR 5016

Query: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
                  + L +   +    +KA  E+I  MN+ E + S E S+   SS+ + +  L +HK
Sbjct: 5017 DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS-EFSLLKTSSSHEAEEKLSEHK 5075

Query: 5103 EFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT-------EFAEHLGEMNRQWHRVH 5155
                       +V  VN    ++   + ++ + E+T         +  +  + ++W R+ 
Sbjct: 5076 A----------LVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLR 5125

Query: 5156 GMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQD- 5214
             +   + + LE  ++  T   NK++     ++  +++L      ++  +    LL+  D 
Sbjct: 5126 AVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDT 5185

Query: 5215 IENQLAIKSKALDELKQSYLT-LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQ 5273
               +L  +  AL  L+Q  L+ L+ GA P   +    + E+   +   L    ++KT+ +
Sbjct: 5186 FVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245

Query: 5274 SVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGS 5333
             V QE K  + +  ++N  +++ W   E  + +      +  Q+E LQ L  EA +   +
Sbjct: 5246 LVKQELKDREMVETQIN--SVKCW-VQETKEYLGNPTIEIDAQLEELQILLTEATNHRQN 5302

Query: 5334 WEKL-QEVIGKLKGL---CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389
             EK+ +E   K  GL    PS   +   +     K   Q+   I +  Q   +  +L + 
Sbjct: 5303 IEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQ 5362

Query: 5390 YSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKE 5444
                  +    L + +AK   +         L E L      + EL   VQK  E
Sbjct: 5363 IQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLE 5417



 Score =  117 bits (292), Expect = 5e-25
 Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)

Query: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
            Y+  +K    +LI     +Q+   +I        + Q +    QK    + +  + + ++
Sbjct: 1244 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1303

Query: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
            A+ + +GE   LP    +E+ KLE  LD   G+ R+R  +     VT  + +        
Sbjct: 1304 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1358

Query: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
            +V+ + +   +H       S  +L +++E  K F ++   + + +QA +    A  +P  
Sbjct: 1359 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1416

Query: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
             QN++    +  +   +VK LE+   +    ++ +  KW+ F  N+ +L       EK+L
Sbjct: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476

Query: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
              L ++  ++ +        ++E E +L        E  SF Q +      +  A+L Q 
Sbjct: 1477 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1536

Query: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
               G++L     C  LEG I       LS  +K +  L ++Q       S +   D+L  
Sbjct: 1537 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1584

Query: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
             ++        +K  ++ +++ Q L+++ S I  F   +++V  + S      ++  Q  
Sbjct: 1585 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1644

Query: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
              L   KE  TA   L A   + E++ +  +T L   + K    +M+    R  +   + 
Sbjct: 1645 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1704

Query: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
             +  ++++   + S +S         LLQ                  + +SL  +++ D 
Sbjct: 1705 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1737

Query: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
                 +      HL +++ +W  +  ++N++I  L+ ++    + +  +   + W++   
Sbjct: 1738 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792

Query: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
              L+T  +  S++  Q  L   +D   ++  K   L  L+     L S      + LL+ 
Sbjct: 1793 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1851

Query: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
             A    +LF++ S V+ +     + +   LQ       +  ++   T+     M  ++  
Sbjct: 1852 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1910

Query: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            ++  + L   ++N ++L+  A S +G   K Q  +             I    Q T  R 
Sbjct: 1911 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1957

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            T     +  ++++ Q+LL                 KQ EA    LA +  +  +  E L 
Sbjct: 1958 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1998

Query: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
             +++DI+E    +   + T++A  Q   V ++L     S  H L         +A  + +
Sbjct: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2054

Query: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
              +  A E +  +++ +   V  +  K LI HE +       +L R +Q  K      L 
Sbjct: 2055 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2110

Query: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
            +  ++      I+   ++       + A   +    +     T+      SEL+ I  ++
Sbjct: 2111 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2170

Query: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
              L         +KW+ + EK+EE    L+V ++                 N +P++ E 
Sbjct: 2171 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2230

Query: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
                      ++  K  E+EV       +   ++   L + T+ +E  P+     + L  
Sbjct: 2231 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2290

Query: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
            + ++A +     KG +       +DFT     + +F+ D +         L++  + +  
Sbjct: 2291 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2343

Query: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
             +L + + +  EL++++ +     +   + C     A  + L   +T  +K  E+V +  
Sbjct: 2344 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2403

Query: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
            S+ Q S ++ +E   +E +++FQ          K+  +     +VL+A+       LH D
Sbjct: 2404 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2455

Query: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
            L N  + + + +  L + TQ   E QT+ A L++ +    V  ++EQI   + +++    
Sbjct: 2456 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2508

Query: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
            +    KQ ++D  +    F +++++L  W+ +ME +   T ++   +     +K+ + ++
Sbjct: 2509 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2567

Query: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
             +F    L  ++  D+L +     S +   A  + +L +++    Q+L  +   +++  +
Sbjct: 2568 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2627

Query: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
                  + L++ + ++  W+  I+  L+      +     ++KRL++ QD+     +   
Sbjct: 2628 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2686

Query: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
             +       +  L  S    N+     IQ    +L   W +I + S+  +  +E     W
Sbjct: 2687 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742

Query: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
              +++  ++ E W++S ++    P   +       VL    +  L   E   R +H  + 
Sbjct: 2743 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802

Query: 6192 QLELINKQYRRLARENRTDTA 6212
            +     + Y +   E+  DTA
Sbjct: 2803 K---SRELYEKTEDESFKDTA 2820



 Score =  105 bits (262), Expect = 2e-21
 Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)

Query: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
            +   K   T L ++ +  SN        E    +L+    EL     +     E++L+  
Sbjct: 1218 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1273

Query: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
             L+  +     +H++    + K++     D +  + +A    G   +   E    L+  L
Sbjct: 1274 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1328

Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
            +  + +   + + ++  L     ++   + +   L ++ +S ++ L+  S +S++ +L++
Sbjct: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1388

Query: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
               ++   E+   +   L  E   + L             ++ ++V KLED L+      
Sbjct: 1389 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1448

Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
             M++ ++    S F T S            V I +++     L+ + S  A+  QI   K
Sbjct: 1449 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1494

Query: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
            V  Q++   ++ ++ ++  +      +          ++T+++   E+ R+    L+   
Sbjct: 1495 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1554

Query: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
               L + ++F+EN   +++ +    + L   +   S   ET + L E +   Q ++    
Sbjct: 1555 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1610

Query: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
               + +       +++V   SC +   + A L++Q+  + ++       L+ LL H    
Sbjct: 1611 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1667

Query: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
             ++      WLE  +   +      +++S D   +   +        EV  ++S  + ++
Sbjct: 1668 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1724

Query: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
             +   L  +  + D   ++  L Q +++W      LP I  K        +   +   E+
Sbjct: 1725 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1780

Query: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
            +     W+     E QT+ E S+     A      L +HK+   E++ K+  +  +   L
Sbjct: 1781 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1834

Query: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
             +L +                     +  S+  ER + A  HL E  +    + G+L + 
Sbjct: 1835 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1894

Query: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
             Q +E                    L++    E+    L+  L   +  LK   + Q+  
Sbjct: 1895 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1954

Query: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
               +  +L  + + I+N L  K     AL  LK+++   +   +  +ED   R D+   K
Sbjct: 1955 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2014

Query: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
                       + + Q++ Q  ++++QL DE+N       +  + +K +         +V
Sbjct: 2015 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2063

Query: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
            +       E    E +W+  + +I + +G C  + +++ E        +  +  A++  L
Sbjct: 2064 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2109

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
            + A S++       +      A  K + AK +       L N +  G +L +E+      
Sbjct: 2110 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2169

Query: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
            D   ++ D++ T + +L  S  L    DRL                 E  ++  +P    
Sbjct: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2229

Query: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
            ++     +L    L+K  EFE   S+ K+  +RLE L   +     +L  L +  +  PD
Sbjct: 2230 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2280

Query: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
              L  + A   Q   +EH  E++   K  L D   ++ Q     N    W      +L  
Sbjct: 2281 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2336

Query: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
            C++      NE     CE  K ++ ++K  ++ + +++++   L    + Y   E E S+
Sbjct: 2337 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2385

Query: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
             + +           QL   T+   +      FS+    +Q    G +        R GD
Sbjct: 2386 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445

Query: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
               L  +  D    ++N+   ++D    L AV  QE  +LY      H  K      Q +
Sbjct: 2446 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2495

Query: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
             T      +A  K  L  D +  +     +   +D  + +   + EM ++F +  E   +
Sbjct: 2496 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2552

Query: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
             ++ I E K+ +  ++    + L   E  + L    +L+ E         +   +L T  
Sbjct: 2553 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2612

Query: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
             +L R        + KE++            +VA+++ E            E  + +  W
Sbjct: 2613 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2646

Query: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
            +  +++++    + +  ++ +EK      + + +  E +++L      G+Q +++SNK  
Sbjct: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2706

Query: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
               I  +L  + + W    D++ S V       + I Q +   +  + L  W+  ++ ++
Sbjct: 2707 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2763

Query: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
              P+        + Q  L E+  L   ++   +  E        L+  S     +TE +S
Sbjct: 2764 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2815

Query: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
             + T +  L  ++ +I  ++ E+  K+EE  +    +LD    F DWL SA+      + 
Sbjct: 2816 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2875

Query: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
                 ++ +++L + +     R+I   RL+++E +  + ++    +  +      Q +  
Sbjct: 2876 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2935

Query: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
              ++W++        L+  V+ +    + F+ Q  + E   E     L     QLT +E 
Sbjct: 2936 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2994

Query: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
                + D+++ +     QEI                 +QK+EP    L + +L EL R+ 
Sbjct: 2995 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3037

Query: 6334 QEV 6336
            +++
Sbjct: 3038 RDL 3040



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)

Query: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
            +L D  ER H   +  +  + K+E         L  +Y  LS   + ES+  + +     
Sbjct: 488  QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 534

Query: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807
             +K G+ +     L+   S +      E ++V +Q  K  A+M +    S +   ++++ 
Sbjct: 535  -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 592

Query: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867
               F  E   + + L  + R     L+ ++  W+ +    ASL+             + +
Sbjct: 593  ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 636

Query: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927
            E+ E+ L +  +  +   RN+     + +  +N+    +   +C E+  +   L++Q L 
Sbjct: 637  EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 692

Query: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984
            LN        R + L   +  Y +  + D++ K       TL+ +  E    +S+ L+  
Sbjct: 693  LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 745

Query: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042
              N+    +  ++++++  +  A   I  +  HL  KE+     +   A   +    L  
Sbjct: 746  FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 805

Query: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
                    L++ Q   +P  +   +M S+ +++         +   + +S +    QKH+
Sbjct: 806  VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 863

Query: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159
            E    +        +++  +QS+ +  T     K +++T     + +++  +  +     
Sbjct: 864  ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 923

Query: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219
               +H+E     + + E     L   L   +E L+    PE ++          D +  L
Sbjct: 924  DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 982

Query: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277
                KA DEL                             + +L +  Q  L+ +++ + +
Sbjct: 983  NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1013

Query: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337
            +WK    L  E     +     +E ++  + S+E  R +++    L  +    EGS + +
Sbjct: 1014 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1065

Query: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379
            +E  V    KG   LC    ++IEE C                H    ++  AI    +K
Sbjct: 1066 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1125

Query: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439
                   WK Y++   E ++ +   E + + +   ++   N  E+     + ++E+++ V
Sbjct: 1126 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1181

Query: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
             K  E     S +  RL    E S+          L + +   K L+   +E E +LS F
Sbjct: 1182 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1238

Query: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558
             D        K ++ +  E L    ++ +E  +  L+      AQ   + H  +   +  
Sbjct: 1239 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1294

Query: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605
               DV  +  Q    +             + +T   LER  E Q      +      KW 
Sbjct: 1295 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1350

Query: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646
                          Q     E  L      SL   LEQ K +        ++AE  + + 
Sbjct: 1351 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1410

Query: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706
                   Q+ QLL     +       +  KL D  +  ++ +   K        +W  F 
Sbjct: 1411 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1459

Query: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760
            ++ E L  ++T+    L+A++         + Q +  I E+++K    +  +    + A 
Sbjct: 1460 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1519

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
             +  GE   +   L     + R   +L++  + +E  +   + Q Q   E   + ++ + 
Sbjct: 1520 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1576

Query: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879
            E + +L V +K  S     E ++ L    +L + LE        +L    T  +   R V
Sbjct: 1577 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1626

Query: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939
            +  D  V  ++   L +Q+ED+  R   R+  +E+ L  W    ++      WL + E K
Sbjct: 1627 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1684

Query: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990
                  DIS +        ++I+ LQ + + + + +S    +L Q+ + L   ++K    
Sbjct: 1685 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1740

Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
             +   L ++++RW+ L  +I  R+  L+   A  QQ D+ + +   W+    SEL     
Sbjct: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800

Query: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099
              + D Q           E++ +  E Q LQ     H A + S+    D+ L    A   
Sbjct: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1853

Query: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159
            E      ++ ++ ++RR   +  ++               +FL  ++     L+   +T 
Sbjct: 1854 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1898

Query: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
               NS     S+++     + L+  +A +         L       +  + E RT   + 
Sbjct: 1899 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1958

Query: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270
              Q+  E  +R  NL    Q    A+    + F +Q+EE   + E I     E       
Sbjct: 1959 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2012

Query: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
            ++  +      ++R  N  + E+  + +++  L    +Q+ QK
Sbjct: 2013 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055



 Score = 91.3 bits (225), Expect = 3e-17
 Identities = 427/2312 (18%), Positives = 886/2312 (38%), Gaps = 391/2312 (16%)

Query: 713  NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
            NQN+    ++E+  ++      TGQ K+A D + ++   E    E + +LD+        
Sbjct: 6511 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6566

Query: 762  ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
                   +T   + +   + K + F  ELMA++  +L+   +        +++L T    
Sbjct: 6567 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6623

Query: 815  KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
               + +   Q+ VV+       L + + D  +D     +  +  L  Y  +  Q+L   +
Sbjct: 6624 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6683

Query: 873  ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
                  S  +L S+  +     +SNT  ++K L  +E +  + T       + +S D+  
Sbjct: 6684 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6738

Query: 925  KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
              +S    L  + QQ + +  E   + D++   L+  K+++ +  L             +
Sbjct: 6739 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6798

Query: 968  RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
            ++  T  L  E     S+    L  +    E L +L  ++LPS+ +  EV     L+++ 
Sbjct: 6799 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6858

Query: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
             QK E  +K +     IH  LQ   G     N   +T            +   +S     
Sbjct: 6859 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6918

Query: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
            T+ A +         +L+ L  E I        +  LLE +  Y        +NN   + 
Sbjct: 6919 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 6964

Query: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
            + F ++E R          + +Q  L D Q +++   A+ KE E I       + + K+ 
Sbjct: 6965 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7024

Query: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
                   TL+E   +    L+  +  L+  L+ VL      K +     S L   + ++ 
Sbjct: 7025 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7083

Query: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
             F L+    +A ++   +L+N+QD + KQ     +     N +LKE HP     + N + 
Sbjct: 7084 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7143

Query: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
            +   ++  +   +     + KAL       +D+     +     E  T+    +A++  +
Sbjct: 7144 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7203

Query: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
            A +   T      +  L+K      D    + ++  +  ++  D S  + + +  + LS+
Sbjct: 7204 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7260

Query: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
             H   +++   ++   L+A +       K+++ +++ I +    +  +DP+         
Sbjct: 7261 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7313

Query: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
             L  + + ++E + +      MA  L    + G    +N ++ +    L  +   + ++ 
Sbjct: 7314 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7373

Query: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
             E+  ++   L Q+Q F    ++ +  L+Q E+ + + +  +Y   ++L ++    E+ +
Sbjct: 7374 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7430

Query: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
             E     ++   ++ +  + Q  L + +  +   F  +  ++ ++W  +  + +     +
Sbjct: 7431 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7487

Query: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
               +  W +   +   + +W  +             + L Q  T  D  + KE++ + +Q
Sbjct: 7488 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7547

Query: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
             +   +    +   L   S     LQ   + I  K +     L  +          A L 
Sbjct: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7601

Query: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
            +D ++ +  I  +   L+      S  +    EE+  + ++ K     LEN +G  T +L
Sbjct: 7602 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7657

Query: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
            ++L    +++S         + N +  +LQ  + +L +          +  N+W  FS  
Sbjct: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717

Query: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
               L E     E+K S      +E+ ++KL      E    + +KI+     L+ + + L
Sbjct: 7718 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7772

Query: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
             KA  +   S +   E++L K+         +  AR K+L+++L  + +L  +  +LR W
Sbjct: 7773 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7829

Query: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
            L + E                                          +E  + I+  +C 
Sbjct: 7830 LAHIE------------------------------------------SELAKPIVYDSCN 7847

Query: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
             +  Q  L +  E++ + +   T   S  +L   ++H            +  +    L+ 
Sbjct: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7907

Query: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
            R    + I  +  E   +IE   +        L QK L D S    W  +    + + S 
Sbjct: 7908 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 7956

Query: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
                   G  Y  +KE       ELKK +    A Q  + E   QL++  K  ++     
Sbjct: 7957 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 7999

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
              D    LK++  +GN             + W  ++    S+L++L+  +   +      
Sbjct: 8000 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046

Query: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
            DS  V +T+++  L N   E  S  D       V+ K+++L+  +  +SL    +++I+A
Sbjct: 8047 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8097

Query: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
              + + + +  +   II++++  L+                   C     + +R  +K  
Sbjct: 8098 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8140

Query: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
            +  LP  E    SD +   ++SAA+  L   W + + DS +    S  LSL+  + +++ 
Sbjct: 8141 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197

Query: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
               R     + + PLE D             L   LE+  +   P E  E   + +    
Sbjct: 8198 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8246

Query: 2490 VLHNIGYSAQHLDNLLQALITLK----KNKESQYCVLRDFQEYLAAVESSMKALLTDKES 2545
            +   +G S   +    +A + L     KN    +  L      L       +  +   E+
Sbjct: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 8306

Query: 2546 L-----KVGP-LDS--VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLE 2597
            +       GP LD+    Y+  + +  +SI+  K     LK + E+L   V   +    E
Sbjct: 8307 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV---NLHSTE 8363

Query: 2598 SQIKQLEHGWEQVEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ--- 2647
            +Q   +   WE ++ Q   K     Q + ++ +F + +N +     DTE  L+Q Q+   
Sbjct: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8423

Query: 2648 -------HLQL-RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
                    LQ+ +LK  ++   ++  I L+ +L + +        QA+         KE 
Sbjct: 8424 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKES 8469

Query: 2700 KNLEDGINNLKKQWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSI 2754
            ++L+D ++ +  +W+     LE      ++ + +C   ++M    +L  +N+    N  +
Sbjct: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529

Query: 2755 PL---LPDDILSQIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLE 2809
            P+   L  +IL    K   ++ H+ +L  Q  V SL +        L   EG+D     E
Sbjct: 8530 PIDSNLDAEILQDHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKE 8585

Query: 2810 DLR---NQYQMLVLKSTQRSQQLEFKLEERSN 2838
             +    N+ ++L+ + ++  ++LE  L+  S+
Sbjct: 8586 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS 8617



 Score = 66.2 bits (160), Expect = 1e-09
 Identities = 672/3633 (18%), Positives = 1382/3633 (38%), Gaps = 481/3633 (13%)

Query: 706  VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
            V L E  +Q  K G    K           + +T    VA+D EK++   V+ W      
Sbjct: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148

Query: 756  VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
            V    ++   +++ L    A+ +   EL+   E  D   ++++    Q+S   +L     
Sbjct: 5149 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5205

Query: 814  AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
            + +Q+           L+  +  + D    L+++ K++ + K ++  +   + +  Q  S
Sbjct: 5206 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5263

Query: 874  PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
                + + KE L  + T  +   L+ ++ L    T   ++I+   EE+       +  L 
Sbjct: 5264 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5322

Query: 931  HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
             ELSL + ++ +D++ + ++ D I ++E+     ++L R+ +   K L        ++  
Sbjct: 5323 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5382

Query: 988  CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
             + Q     +VL    EEL    S+      L + +  +++ L+   ++   L    G  
Sbjct: 5383 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5433

Query: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
            T  ++ TI  +ENR    +  A   +  N+         EKA      T+ ++ AS LR 
Sbjct: 5434 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5493

Query: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
              +  ++++E  K+  + + ++ E+      +   +      +  ++   E +     ++
Sbjct: 5494 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5550

Query: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
             +L +LQ    +      E + +   LE     +  P V   R +LKE+    Q  L + 
Sbjct: 5551 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5607

Query: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
            MESL+  ++ V         LC S L + +  +    L  A  R+ +    +Q +  +Q 
Sbjct: 5608 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5658

Query: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
              CN                    MQ  +++Y+   + M H  Q  E   + +ED     
Sbjct: 5659 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5692

Query: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
                ++   + +L A  ++  +E    +K  + +I  +  K K L    K   M     E
Sbjct: 5693 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749

Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
                      LD   +     H   V       + LL     ++ E     +   S+IS 
Sbjct: 5750 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5804

Query: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
                + P     T  +V         L     + +  K H    A S   ++ G E +  
Sbjct: 5805 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5863

Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
             +  +    WE  K +++E        LE  ++YQ+    ++T ++  E  + L  S   
Sbjct: 5864 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5921

Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA-----N 1621
              + + ++AE + + +E    L + D+IN++  +L   L   ++ E  P E+ A      
Sbjct: 5922 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQLALQSTLT 5977

Query: 1622 IIVDRWLDI-----------NEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKME 1670
            ++ +R   I            EK  D  E   +  AL  +     + +D W       ++
Sbjct: 5978 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL-QRYRCEADELDSWLLSTKATLD 6036

Query: 1671 LHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHV 1730
                  ++   ++ +L   +    E  ++V  +  L     +  E  ++E     K E  
Sbjct: 6037 TALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL----SVHNENLLLEGKAHTKDEAE 6092

Query: 1731 QKCLTGESNCHALSGSTAELREDLDQAKTQIGMT----ESLLKALSPSDSLEIFTKLEEI 1786
            Q  L G+     L GS  EL+  L   +  +  T    E     L+ + S  +   L + 
Sbjct: 6093 Q--LAGK--LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQA 6148

Query: 1787 QQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLND---- 1842
            +    QQ+ S +  + +   L  EL+E K    SV+     ++ ++Q   ++   D    
Sbjct: 6149 RTTWTQQRQSSLQQQKE---LEQELAEQKSLLRSVAS--RGEEILIQHSAAETSGDAGEK 6203

Query: 1843 -----QCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
                 Q        S+ +  ++  +ES   + S +QKL  L + L  E       + + +
Sbjct: 6204 PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL--LQNVLEQEQEQVLYSRPNRL 6261

Query: 1898 LKHV---KKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRN 1954
            L  V   K  +P      + S L G     E++ S     AK     L+Q  +L D    
Sbjct: 6262 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSS-QSGGAKRQSIHLEQ--KLYDGVSA 6318

Query: 1955 LRKWLTNQEEK-WKGMEEPGEKTE--LFCQ-ALARKREQFESVAQLNNSLKEYGFTE--E 2008
               WL + EE+ +       E+TE  LF Q  LA+  ++       N +L    F E  +
Sbjct: 6319 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 6378

Query: 2009 EEIIMEAT--CLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
               ++E T  CL+ R   L   +++   + K    +  +F +    +   + + K  ++ 
Sbjct: 6379 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQ 6438

Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE--SSEAPLVQKTLTDISNQWD 2124
              ++  + P+ E+I+ I++      E DA I  + ++ +    E P +Q+ L+ + + +D
Sbjct: 6439 KLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE-LSKLQDMYD 6497

Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG-----FALQHGLQEKK 2179
              + +  +  S   + L    +Y ++ +DL   L+E  +++ AG      + +  +Q+  
Sbjct: 6498 ELMMIIGSRRSGLNQNLTLKSQYERALQDL-ADLLETGQEKMAGDQKIIVSSKEEIQQLL 6556

Query: 2180 AQLKIYKKFLKKAQDLTSLL----------KELKSQGNYLLECTKNPSFSEEPWLEIKHL 2229
             + K Y + L+    LT  L          KE +     + + +     + +  +E++++
Sbjct: 6557 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6616

Query: 2230 HESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKL 2289
             E+    L +  Q L    R+ +  +  +  +    +N         D+ +D+I + + L
Sbjct: 6617 LET-WSHLDEDQQELS---RQLEVVESSIPSVGLVEEN--------EDRLIDRITLYQHL 6664

Query: 2290 Q-KLQELENRL--SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRL 2346
            +  L E + +L   L DG    I      ++   + +G+  + +  K      K+L    
Sbjct: 6665 KSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK----MSKELHR-- 6718

Query: 2347 ASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEIN 2406
                      L +ILK     + +    +   +  A   ++  TQ+S  V    ++ E+ 
Sbjct: 6719 ----------LETILKHWTRYQSESADLIHWLQ-SAKDRLEFWTQQSVTV---PQELEMV 6764

Query: 2407 KDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLEL---DTMLRNEQLEEIEKLYT 2463
            +D  +   +     ++AQ S+K++     V    NQ L L   DT     +L  I+  +T
Sbjct: 6765 RDH-LNAFLEFSKEVDAQSSLKSS-----VLSTGNQLLRLKKVDTATLRSELSRIDSQWT 6818

Query: 2464 QLEAKKAAIK---------PLEQTECLNKTETGALVLHN------------IGYSAQH-- 2500
             L     A++          L     +++  +   ++ N            IGY A H  
Sbjct: 6819 DLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEY 6878

Query: 2501 -----------------LDNLLQALITL-KKNKESQYCVLRDFQEYLAAVESS---MKAL 2539
                             +D + Q+++ +  ++ ES+     DF E L A+  S   ++ L
Sbjct: 6879 LQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 6938

Query: 2540 LTDKESLKVGPLDSVT-YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES 2598
            +T+K  L  G L+S + Y + ++      E ++  L       +  S      D + LE 
Sbjct: 6939 VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLED 6998

Query: 2599 QIKQLEHGWEQVEQQ----IQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLK 2654
             IK  E   E++EQ     IQ K  ++ V     +TL  ++  T  +L      L++ LK
Sbjct: 6999 LIKAKEKEVEKIEQNGLALIQNK--KEDVSSIVMSTL-RELGQTWANLDHMVGQLKILLK 7055

Query: 2655 SPEERAGNQSMI--ALTTDLQATKHG---FSVLKGQAELQMKRIWGEKEKKNLEDGINNL 2709
            S  ++  +  +    + + L   ++    F +L G  E    ++       NL++  ++L
Sbjct: 7056 SVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV------DNLQNLQDDL 7109

Query: 2710 KKQWETLEPLHLEAENQIKKC------DIRNKMKETILWAKNLLGE----LNPSIPLL-- 2757
            +KQ  +L+         +K+C       + N +KE  +   NLL E    L  S  LL  
Sbjct: 7110 EKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL 7169

Query: 2758 -----------------PDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYE 2800
                              +D  +++ K     D        V +  ++  D +  L T +
Sbjct: 7170 WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVK 7226

Query: 2801 GS--DLNNTLEDLRNQYQMLVLKSTQRSQ--------QLEFKL-EERSNFFAIIRKFQLM 2849
             S   L+   E L+ Q       + Q  Q         LE  L +++++  A +  ++  
Sbjct: 7227 DSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETF 7286

Query: 2850 VQESETLIIPRVET-AATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELN-V 2907
             +  E L    VE     + +   H   L   Q+ ++E+  G       +    + LN +
Sbjct: 7287 AKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL-KGQMLKFSSMAPDLDRLNEL 7345

Query: 2908 FERLFLED----QLKNLK-----IRTNRIQRFIQNTCNEVEHK--IKFCRQFHE-KTSAL 2955
              RL L D    +++NL      I +   +RF +     ++H+  ++ C  + E      
Sbjct: 7346 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTE 7405

Query: 2956 QEEADSIQRN--ELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWD 3013
            Q+ A  I  N   LL  Q  ++  + E+++ +  L +I     ++L+  +V D    N  
Sbjct: 7406 QKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7465

Query: 3014 FSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVV 3069
             + L      V  + ++    ++ +I+Q   + E   K +  L ++  + +       + 
Sbjct: 7466 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP 7525

Query: 3070 LKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEE 3129
            L+   +  +  +   ++   R + +  L  E  K+L  +    DS  E   LQ +L AE 
Sbjct: 7526 LQQARTLFDEVQFKEKVF-LRQQGSYILTVEAGKQLLLSA---DSGAE-AALQAEL-AEI 7579

Query: 3130 NDKLYKVLQNMVLELSPKEL-----DEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKH 3184
             +K      +M LE   K+L     D + C+  +  SL  L   K +L Q L  + E  H
Sbjct: 7580 QEKWKSA--SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELH 7637

Query: 3185 IQNEKDNCEAFQEQV--W----AEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQM 3238
               E+  C+  +  V  W     ++  +K   +     ++ S     VE   R++E+L  
Sbjct: 7638 A--EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7695

Query: 3239 QLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEA-------IIIPYRVDVGNPEE 3291
            QL+    LR   + +       + E      E +T +E+       I+I   ++    + 
Sbjct: 7696 QLS----LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDY 7751

Query: 3292 SLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE 3351
              E+ + ++ +++     +Q + E+L   S      +++Y L ++  +   + +   A+ 
Sbjct: 7752 QEEIAIAQENKIQ-----LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 7806

Query: 3352 TEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLI 3411
             + +  L   +   K    + T L+ +E+ L + +     +  E   +L + + L  ++ 
Sbjct: 7807 KKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 7866

Query: 3412 STKEELMKLRQILRLLRLRC----TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEEL 3467
                 +  +  +  +L   C    T+ +   + +    L  +W ++   + E  +  EE 
Sbjct: 7867 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 7926

Query: 3468 KQEWKFVSEEIEREAIILDNLQE--ELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ 3525
             + W+   ++  R    L + +     P  S        EEL +       +   V +  
Sbjct: 7927 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE----AFQRQVHECL 7982

Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
              L L+ ++ R +     +  A        E     +   K +  + +  +    + +E 
Sbjct: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
             +    I+          T+ ++ +  D   K +Q +  Q  +       E I+ +    
Sbjct: 8043 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8102

Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
              +   +  A IE +++E R+  +++  ++             R   + I   L + E  
Sbjct: 8103 IEKSEPLDAAIIEEELDELRRYCQEVFGRVE------------RYHKKLIRLPLPDDEHD 8150

Query: 3706 LQQKSKNIEKAQEIQKKMW-----DELDLWHSKLNELDSEVQDIVEQDPGQ-AQEWMDNL 3759
            L  +   +E +  +    W     D L       N   S  Q +  +  G+     +D++
Sbjct: 8151 LSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI 8210

Query: 3760 MIPFQQYQQVSQRAECRTSQLNKATVKMEE---------------YSDLL--KSTEAWIE 3802
             + +     +S+  E   S +++A    +E                SD++  +S EA+++
Sbjct: 8211 PLEWDHDYDLSRDLE---SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVK 8267

Query: 3803 NTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQ 3862
             T + + N +   S   L      +  AL+DS  +                I +T+ + +
Sbjct: 8268 LTENAIKNTSGDHS--ALESQIRQLGKALDDSRFQ----------------IQQTENIIR 8309

Query: 3863 SIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSK-EIFDF 3921
            S      ++    +  M+ L +     D V  +E ++K  E+ +     +  ++ +    
Sbjct: 8310 SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8369

Query: 3922 SPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLE 3981
                 L   + + + +R MK+ + +   +  +L      +        T + L+ ++ LE
Sbjct: 8370 IDRWELLQAQALSKELR-MKQNLQKWQQFNSDLNSIWAWLGD------TEEELEQLQRLE 8422

Query: 3982 NVTQEQNELLKVVIKQTNEWDEEIENLKQI---LNNYSAQFSL--EHMSPDQADKLPQLQ 4036
              T  Q   +++ IK+  E  + +++ K I   +N  S +F+      S D  D+L Q+ 
Sbjct: 8423 LSTDIQT--IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMN 8480

Query: 4037 GEIERMEKQILSLNQRKEDLLVDLKATVLNLHQ 4069
            G  +R    + SL +    LL D        H+
Sbjct: 8481 GRWDR----VCSLLEEWRGLLQDALMQCQGFHE 8509



 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 325/1714 (18%), Positives = 644/1714 (37%), Gaps = 315/1714 (18%)

Query: 311  EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
            + L+ L+K  E +    + N L + +++  E+  S   V+S  R+L +           W
Sbjct: 6994 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7040

Query: 371  DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
              LDH +   KI L   L        A+ +    LM+   S S+    + ++  +Q ++ 
Sbjct: 7041 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7100

Query: 429  LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
              ++L D  E     L     +T +   E H P+     N L+E+  R NN+LE+    +
Sbjct: 7101 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7156

Query: 482  LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
             E       +L L    K  SK     ++     + ELL    +K I + E    + T  
Sbjct: 7157 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7212

Query: 540  QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
            Q C ++ K L                      A     I    + +   +C   + +   
Sbjct: 7213 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7272

Query: 578  KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
            +++LQ  +  + T+ ++L  L A   E                 T +E ++E+  + L  
Sbjct: 7273 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7332

Query: 621  WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
             ++  +   LNE G  L     ++      K ++ LN+ W  + S+T    +       Q
Sbjct: 7333 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7386

Query: 679  DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
             Q   +     +    +  V+    ++VE+  NY   ++    HE    E   + ++   
Sbjct: 7387 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7442

Query: 738  ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
               D ++L+ Q ++                W+       + + ++D    Q      M E
Sbjct: 7443 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7502

Query: 769  SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
             L+  + + S                   +FDE+  + +  L+     I + E+ + +L 
Sbjct: 7503 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7562

Query: 810  T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
            +        LQA++ E +EK +   ++L    K L  +  D +   K + +S ++L ++ 
Sbjct: 7563 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7622

Query: 862  MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
             +  Q L          ++  K  E  + S T  L +     + L   ++ D    L E+
Sbjct: 7623 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7682

Query: 919  SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
               +  +WE L H+LSL  QQ+        +  EK K L + + ++E ++++   ++   
Sbjct: 7683 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7742

Query: 971  RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
              + L K++  E   ++E  + QL    E L +   E  + + + ++ ++   ++  ++ 
Sbjct: 7743 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7801

Query: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
            +   +K   E  + +Q      S     +   E+    P      +SE    K + Q   
Sbjct: 7802 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7861

Query: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
            ++ +E      +ASVL  L E  + + D  A      SI       D  +R+I    +E 
Sbjct: 7862 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7919

Query: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
             L+  +      +   D+S  ED  +SS    A  +   VI        K+FE    ++ 
Sbjct: 7920 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 7979

Query: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
              +     I K +    R+   +    L+  +   N R ++L+  +  +L          
Sbjct: 7980 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8039

Query: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
                  + S+L+  +++ L    I+ F   D     + L+  Q  I+       ++   G
Sbjct: 8040 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8099

Query: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
              ++++  P D   ++  + + +   + +  RV+R    L                    
Sbjct: 8100 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8159

Query: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQ------VAQENTLTVKN----KEGEIH 1368
               AL D     R+A   LS +P ++LS S  Q        ++   +V +     + +  
Sbjct: 8160 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 8219

Query: 1369 LMKDKAKHLDKCLKMLDMSFKDAE----RG----DDTSCENLLDAFSIKLSETHGYGVQE 1420
            L +D    + + L   D   +D +    RG     D       +A+ +KL+E       +
Sbjct: 8220 LSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAY-VKLTE----NAIK 8274

Query: 1421 EFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKKSLIRL--- 1473
              + ++  LE+ I    +L K + D + QI +    I  K PT P +    K  ++L   
Sbjct: 8275 NTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8331

Query: 1474 -DKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGR 1532
                +D  +  +  L+E   SLP F +    +   Q    +  WE    L  + L +  R
Sbjct: 8332 CSSSIDSVKRLEHKLKEEEESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELR 8386

Query: 1533 VLELLKQYQNFKSILTT----LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHL 1588
            + + L+++Q F S L +    L   EE +  LQ     +  L   I  IE+  ++  E  
Sbjct: 8387 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQ 8441

Query: 1589 EVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW 1648
            + VD    +  ++            P F +            ++++ D  + L +    W
Sbjct: 8442 KAVDHRKAIILSINLC--------SPEFTQAD----------SKESRDLQDRLSQMNGRW 8483

Query: 1649 DKLFNLKNVIDEW----TEKALQKMELHQLTE------EDRERLKEEL-----QVHEQKT 1693
            D++ +L   ++EW     +  +Q    H+++       E+ +R K E+      +  +  
Sbjct: 8484 DRVCSL---LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 8540

Query: 1694 SEFSRRVAEIQFLLQSSEIPL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELRE 1752
             +  +++ +I+  L  S++ +  LQ M   +L   E    CL  +   H +      L+ 
Sbjct: 8541 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKL 8596

Query: 1753 DLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEI 1786
             L +    I   E LL   S    L  ++  +E+
Sbjct: 8597 LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 8630



 Score = 41.2 bits (95), Expect = 0.036
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 305  WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
            W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432

Query: 362  DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
               +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 8433 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8488

Query: 422  LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
            L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 8489 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548

Query: 460  --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
               ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8596

Query: 518  LLEDWHKFIEEKEFLARLDTSFQ 540
            LL++  + I+E E L  + +S Q
Sbjct: 8597 LLKEVSRHIKELEKLLDVSSSQQ 8619



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)

Query: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
            ++ + KE++  +  + ++L   Q ++++L       +H  V+  M  K QIEHL    HR
Sbjct: 323  DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 381

Query: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
              + L L  A+ KQ    +  RL  W +  +K+       + AWL + E  V    +I++
Sbjct: 382  DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 438

Query: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
            +++ E+       ++    +   N    K+   ++ +  + +      D+L  + +R+  
Sbjct: 439  QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 498

Query: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
            +       + K   L+  +  +  L    S L++W+ +     S          +++ + 
Sbjct: 499  VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 549

Query: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
                 +  +  EQ+    + +    ++ +    A  +  E +++ +       +WRN+  
Sbjct: 550  YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 606

Query: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
                 R  +EE    W ++ +  +  + WL+ AE+     N SE    +AK++      F
Sbjct: 607  EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 653

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
             R +   + Q   +N     L        +  LKQ +   N RW  L   V     +   
Sbjct: 654  FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 712

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
                ++E+     ++  + TE   +L+     S  +    ++ L   +Q + +   +  +
Sbjct: 713  MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 771

Query: 6303 LIVFGEQLIQKSEP 6316
            +I     LI K  P
Sbjct: 772  IITKTAHLITKESP 785



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)

Query: 6549 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6608
            +K       S+   ++ W+ + E EL  L+ +    D+Q  +++V  +QEI    ++  +
Sbjct: 1451 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1505

Query: 6609 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6667
             +V +   ++ F Q   + ES  ++++L Q+    E  +       G +   L Q Q F 
Sbjct: 1506 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1565

Query: 6668 Q 6668
            +
Sbjct: 1566 E 1566


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 2246 bits (5819), Expect = 0.0
 Identities = 1813/6597 (27%), Positives = 3149/6597 (47%), Gaps = 584/6597 (8%)

Query: 733  LKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDT-----------SMEESLKHLIAKGSMFD 781
            LK  KD++K     E+   ++     Q+++++           S+  ++  LI K     
Sbjct: 2339 LKKVKDIQK-----ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2393

Query: 782  ELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVS 841
            +L ++++  LQ  ++   S ES Q      L AK                AA K  +D +
Sbjct: 2394 QLCSKTQASLQESLEKHFS-ESMQEFQEWFLGAK----------------AAAKESSDRT 2436

Query: 842  PDLDI-RLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
             D  +   K+ + Q  L+S +   Q  L      G+ +  H    I+S+ +   +  KA 
Sbjct: 2437 GDSKVLEAKLHDLQNILDS-VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE--QITKAN 2493

Query: 901  EELKNNVTEDIKMSLEEKSRDVCAK----WESLHHELSLYVQQLKIDIEKGKLSDNILKL 956
            EE +  + + +K   ++++   CA     +E  H +L+L++ +++       L ++   +
Sbjct: 2494 EEFQAFLKQCLK---DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHI 2550

Query: 957  EKQINKEKK-------LIRRGRTKGLIKEHEACFSEEG---------CLYQLNHHMEVLR 1000
             ++ N+  K       L+    +   + +     SEEG         C   L  H  +LR
Sbjct: 2551 PEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLR 2610

Query: 1001 ELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTS------------ 1048
               E+L S +   +    L++  Q +   +K   +     + T G               
Sbjct: 2611 MTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDI 2670

Query: 1049 ---KNEGTITTSENRGGDPHSEAPFAKSDN---QPSTEKAMEPTMKFSLASVLRPLQEES 1102
               K EG +  +   G    +     K      Q   E   E       +SV      ES
Sbjct: 2671 LLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES 2730

Query: 1103 IMEK--DYSASINSLLERYDTYRDILEHHLQ-----NNKF----RITSDFSSEEDRSSSC 1151
            ++ +  DY    N L +  ++    +EH LQ       KF     + S  S  ED + + 
Sbjct: 2731 VISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL 2790

Query: 1152 LQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLN 1211
             +      ++ +   D  +K+     LK +   NDI            KE+ R+++  + 
Sbjct: 2791 HRLIAKSRELYEKTEDESFKDTAQEELKTQ--FNDIMT--------VAKEKMRKVEEIVK 2840

Query: 1212 TRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQ 1271
              +  L+        V + +  L  +   LH+ +          +    ++ + DS    
Sbjct: 2841 DHLMYLDA-------VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIG 2893

Query: 1272 IEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLAS 1331
                +R+E     V +         M   +   +  ++     V +++  L+ L   +A 
Sbjct: 2894 ASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA- 2952

Query: 1332 LRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD------KCLKMLD 1385
                 LS +  +   A   Q  ++ +  +K    ++ L++ K    +      K  ++LD
Sbjct: 2953 -----LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILD 3007

Query: 1386 MSFKDAERGDDTSCE-NLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQ 1444
               K   R +D   + N L  FS  LS T+   V     E N L   C+  +       Q
Sbjct: 3008 ALQKAEPRTEDLKSQLNELCRFSRDLS-TYSGKVSGLIKEYNCL---CLQASKGCQNKEQ 3063

Query: 1445 DVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT 1504
             +Q +  K         A +  ++ L+       +  +  +++ E++ SL   ++   ++
Sbjct: 3064 ILQQRFRK---------AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES 3114

Query: 1505 VNQQCQNTVVLWENTKALVTECLEQC-GRVLELLKQYQNFKSILTTLIQKEESVISLQAS 1563
             N Q +  ++L +          E+  G   ++    +++K+  + L QKE ++      
Sbjct: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESAL------ 3168

Query: 1564 YMGKENLKKRIAEIEIVKEEFNEHLEVVDK---------------------INQVCKNLQ 1602
                ENLK ++ + E+  E   + L   +K                     +  V + + 
Sbjct: 3169 ----ENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIH 3224

Query: 1603 FY---LNKMKTFEEPPFEKEA---------NIIVDRWLDINEKTEDYYENLGRALALWDK 1650
             Y   LN++K   +  +E +A         + +  ++L ++  T++    L R +A  ++
Sbjct: 3225 CYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQ 3284

Query: 1651 LFNLKNVIDEWTEKALQKMELHQLTEEDRE-------RLKEELQVHEQKTSEFSRRVAEI 1703
                   + +W   A+  ++ +     D+        +L+  L V ++K  +    V   
Sbjct: 3285 FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRG 3344

Query: 1704 QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA-LSGSTAELREDLDQAKTQIG 1762
            + +LQ++  P  +  ++  + +  +     L+    C + L G+ ++     D  +   G
Sbjct: 3345 ESVLQNTS-PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3403

Query: 1763 MTESLLKALSPS--------DSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTP----- 1809
              +S+   L+ S        D   +  K + + +++L     +  +E +   +T      
Sbjct: 3404 WMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQ 3463

Query: 1810 -ELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQ----CKNFNDWFSNIKVNLKECFES 1864
             EL +L+++Y ++ +    K++V +      L+ +     K F  W    +  L +    
Sbjct: 3464 LELQDLQERYRAIQE--RAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVL 3521

Query: 1865 SETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFEL 1924
                 + E  L+ L +          +  ++SVL H ++ +  + + +       ++  L
Sbjct: 3522 EGDAHTHETTLRDLQELQVHCAEGQAL--LNSVL-HTREDVIPSGIPQ------AEDRAL 3572

Query: 1925 EKMESICQARAKELEDSLQQL------LRLQDDH-RNLRKWLTNQEEKWKGMEEPGEKTE 1977
            E +    QA    L ++  Q       LRL +   + + +WL   EEK            
Sbjct: 3573 ESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRA 3632

Query: 1978 LFCQALARKREQFESVAQLNNSLKEYGFTEEE---------EIIMEATCLMDRYQTLLRQ 2028
                 L + ++  E V    + ++E G   +E          +  +AT L  RYQ LL Q
Sbjct: 3633 TKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQ 3692

Query: 2029 LSE----IEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIK 2084
            + E    +EEE + L   + S +  +     W     ++   + +   K+      +K+K
Sbjct: 3693 VLEQIKFLEEEIQSLEESESSLSSYSD----WYGSTHKNFKNVATKIDKVDTVMMGKKLK 3748

Query: 2085 EI-ILLKP--EGDARI-------ETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYL 2134
             + +LLK   +G + +       E  +K  E  EA  ++K + D   Q            
Sbjct: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEH 3808

Query: 2135 SHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQD 2194
               EK L   +++    + L   + E ++        +  L EKKAQL  YK   +    
Sbjct: 3809 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLS 3868

Query: 2195 LTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSY 2254
                +K ++ +G  LLE  ++ +  ++   +++  ++ L    ++ V +L+  V++H+ Y
Sbjct: 3869 HEPSVKSVREKGEALLELVQDVTLKDKID-QLQSDYQDLCSIGKEHVFSLEAKVKDHEDY 3927

Query: 2255 QVCVTDLNTTLDNFSKEFVS-----------FSDKPVDQIAVEEKLQKLQELENRLSLQD 2303
               + ++   L   S   V+            + +     A+ E++   ++  N L ++ 
Sbjct: 3928 NSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKG 3987

Query: 2304 GTLKKILA--LAKSVKQNTSSVGQKIIKDDIKSL----QCKQKDLENRLAS------AKQ 2351
             TL    A  L   +KQN  +  Q   KD   ++    Q   + LE+ L          Q
Sbjct: 3988 DTLIGQCADHLQAKLKQNVHAHLQGT-KDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046

Query: 2352 EMECCLNSI--------------------LKSKRSTEKKGKFTLP----------GREKQ 2381
            + +  L+++                    +K  R+ +++ +  L              K 
Sbjct: 4047 QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106

Query: 2382 ATSDVQESTQ----ESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVN 2437
               D+Q++ Q    +    + L + WE  K    E+ +  Q +    ++MK    E ++N
Sbjct: 4107 TAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELN 4166

Query: 2438 ELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPL-EQTECLNKTETGALVLHNIGY 2496
              QN             + +++    +L++K+A++  + E+   L K E           
Sbjct: 4167 IAQNM------------VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHL 4214

Query: 2497 SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVT- 2555
            + Q LD L +    L   +E      RD+ + +  VE  ++   T+ ++L     +S   
Sbjct: 4215 NDQWLD-LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAV 4273

Query: 2556 YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQ 2615
            +L+ +KK   ++++ K ++ +LK + + +  H+   DK+L++ Q   LE  W Q+E  I+
Sbjct: 4274 HLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK 4333

Query: 2616 KKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS--PEERAGNQSM--IALTTD 2671
            +K    V   +E   + ++ Q+     ++QQ ++   LK   P + A N  M  +A+ ++
Sbjct: 4334 RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393

Query: 2672 LQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKC- 2730
            L+A +     L   A+  M  + G  E++ ++  +++ +     L  L  +    + K  
Sbjct: 4394 LEAKQMLLKSLIKDADRVMADL-GLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKAL 4452

Query: 2731 DIRNKMKETILWAKNLLGE------LNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
              + +    +  A + + +          I LLPDD+  Q++ CK     +   Q  V  
Sbjct: 4453 SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTG 4512

Query: 2785 LAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIR 2844
            L  + ++ +  +T  E S++   L++L++ Y  ++ K + R Q+LE  L  R +F     
Sbjct: 4513 LWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFD 4572

Query: 2845 KFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEE 2904
            K    +++++ +  P +      +EL       +   ++  E ++ + T  +    I   
Sbjct: 4573 KACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS 4632

Query: 2905 LNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQR 2964
            LN  +  +L ++L  L  + N I    ++   +V+  I   +++        +    ++ 
Sbjct: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4692

Query: 2965 NELLLNQEVNKGVKEEIYNLKDRLTAIKC-------CILQVLKLKKVFDYIGLNWDFSQL 3017
              L +++       EE  +L+D   AI          + ++ + K+ F   G  W   ++
Sbjct: 4693 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKM 4752

Query: 3018 DQLQTQVFEKEKELEEKIKQLD----TFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAP 3073
              L T     +++ E+++  L+     ++E     Q L  +++++  +  K+ E  L A 
Sbjct: 4753 LHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAE 4812

Query: 3074 DSSPESRRLNAQILSQRI--EKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEEND 3131
            +       L   +    I  ++     +++   L      D    EK   QI+    E  
Sbjct: 4813 EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHL------DPLAYEKARHQIQSWQGELK 4866

Query: 3132 KLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
             L   +   V E   + +   + Q ++  SL  L ++K++L  P+ ++L ++ IQ E   
Sbjct: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRK 4926

Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSE--ASDVETKLREFEDLQMQLNTSIDLRTN 3249
             +  QE+V + +  + A++  EK++   + E  ++D+E  L E  +L   +  ++  R  
Sbjct: 4927 IQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQA 4986

Query: 3250 VLNDAYENLTRYKEAVTRAVESITSLEAII--IPYRVDVGNPEESLEMPLR---KQEELE 3304
             L + Y    RY +    A + +   + ++      +DV + EE+L+  +     +++  
Sbjct: 4987 TLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFH 5046

Query: 3305 STVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCY 3364
            S +  +  L   L  +  P  K  L+  +  L  ++  M     AQ    +R    +  Y
Sbjct: 5047 SNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5106

Query: 3365 RKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQIL 3424
            +K  E++   ++  E  L +       S  EA E+L + KALVS + S  E+++ L +  
Sbjct: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEE-- 5164

Query: 3425 RLLRLRCTENDG--ICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREA 3482
            +  +L  T ND     L + ++ +W++W  L   A++ E   E+   EW   + ++++  
Sbjct: 5165 KASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT 5224

Query: 3483 IILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542
             ++D LQ++LP    + E A+  EL  LL+    +   +E+QQ  L +L Q+  S+    
Sbjct: 5225 EMIDQLQDKLP--GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDG 5282

Query: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
             +    E  P  QEIT+M++RC  + +KV+ N +LV+ E+++R     +I ++K + Q+T
Sbjct: 5283 AAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQET 5342

Query: 3603 TTSFQNMAFQ----------------DHPEKSEQFEELQSILKKGKLTF----------- 3635
                 N   +                +H +  E+  E Q     G  T            
Sbjct: 5343 KEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5402

Query: 3636 --------ENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKIS----NEVLKSS 3683
                    + I +K  IK  E       E+  Q+++  K L  I  K+     N V   +
Sbjct: 5403 VALDLKIRDQIQDK--IKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT 5460

Query: 3684 PSYAMRRKIEEINNGLHN----VEKMLQQK-------SKNIEKAQEIQKKMWDELDLWHS 3732
                +  +++  N+ L      V+K L+Q        +K I K  E+ ++   + +   S
Sbjct: 5461 DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS 5520

Query: 3733 KLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSD 3792
            KLN+  S +++  E       +W++   +        +  ++ R   +   T+ +EE  +
Sbjct: 5521 KLNQAASHLEEYNEMLE-LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL-LEESKE 5578

Query: 3793 LLKSTEAWIENTSHLLA-------NPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIF 3845
            +    EA  E   +L +       +    +  R        +++ L++ +     +    
Sbjct: 5579 IDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638

Query: 3846 MDLEDLSIIFETDELTQSIQE-----LSNQVTALQQKI--MESL-PQIQ---------RM 3888
             +L+ L    E  + T +  E     L  Q++  Q  +  MESL P++Q         R+
Sbjct: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRI 5698

Query: 3889 ADDVVA----------IESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILE--- 3935
             +DVVA          ++ E   ++    +   I+ +  +     E+ +KH + ++E   
Sbjct: 5699 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5758

Query: 3936 -----------NIRPMKKTIA-------EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDI 3977
                       NI+ ++  I+       +I  YQ ++    +  K L +  +   +L  +
Sbjct: 5759 REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818

Query: 3978 KLLENVTQEQNELLKVVIKQTNEWDEEIEN--------LKQILNNYSAQFSLEHMSPDQA 4029
              +E + +   +L   ++   +     +          L  +      + +   +S   A
Sbjct: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878

Query: 4030 DKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSE 4089
             + P      +    Q ++  Q        L+     +H      QE  E    P+ T++
Sbjct: 5879 CRSPSPVANTDASVNQDIAYYQALS--AERLQTDAAKIHPSTSASQEFYEPGLEPSATAK 5936

Query: 4090 EGGVA------ERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSL 4143
             G +       +   SE++     ++      ++ ++  S K +  + K   SP+   S 
Sbjct: 5937 LGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS- 5995

Query: 4144 WKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQT-- 4201
               +  M E +A      ++Q+   +I+   +S+A+ L  +S   +   + +L+   T  
Sbjct: 5996 --PESQMAEHQALMDEILMLQD---EINELQSSLAEELVSESCEADPAEQLALQSTLTVL 6050

Query: 4202 -EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE 4260
             E  +T  ++A        +  L  ++E+ R E  + L   + +  EL+ WL      ++
Sbjct: 6051 AERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--QALQRYRCEADELDSWLLSTKATLD 6107

Query: 4261 PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETC---KDQGLGDNGATQHEAEALSL 4317
                       +E QL+ CQ ML EIE KV  L E     ++  L     T+ EAE L+ 
Sbjct: 6108 TALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAG 6167

Query: 4318 KLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFS 4377
            KL+ +K +L ++Q  L +K    Q     K+ S+ +      P     L    T   Q  
Sbjct: 6168 KLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ-Q 6226

Query: 4378 RQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDV 4437
            RQ   QQQ+ LE +  EQK  ++ +    +++  Q+   +  T+ ++       S E  +
Sbjct: 6227 RQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAE--TSGDAGEKPDVLSQELGM 6284

Query: 4438 PDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQ----VSTNMGILPSVTMYNFRYP 4493
                 S + Q   KW+ LH E S+K KL    L + Q     S    +L  V +Y    P
Sbjct: 6285 EGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVP 6344

Query: 4494 TTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            T ++    T+ L+ L Q    + +Q    +   I+L++KL++     S  L  VEE L +
Sbjct: 6345 TQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFV 6403

Query: 4554 PR-LYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQV 4612
               L  E+      + E LA ++K++   +   K    +A    G+N +++ +    L  
Sbjct: 6404 ATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 6463

Query: 4613 CLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQL 4672
             L    +    R   +K  L    ++QN++K L+  L  +K  + Q L  +  Q VAEQ+
Sbjct: 6464 RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 6523

Query: 4673 QKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSS 4732
            +        L+  ++ + +L+  G++L +    +QE+ KL+D+ D +  ++ +R + L+ 
Sbjct: 6524 EAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQ 6583

Query: 4733 PFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLL 4792
                +SQ +  LQ + +L++ G+EK+A        SK  +Q  ++ HK +FQ L + M+L
Sbjct: 6584 NLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMIL 6643

Query: 4793 IQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEK 4852
             +    KI+   +Q    F  E + +   + +++ + G++L+ +L+ W   DE+   L +
Sbjct: 6644 TETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR 6703

Query: 4853 DLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCP 4912
             LE++ S++PSV LVEE E+RL++RI+ YQ +K ++     +LYQ L++GK+L+ S+SC 
Sbjct: 6704 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6763

Query: 4913 ELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972
            +LE Q+ +L E WLS   K+  ELHRL+ +LKH   Y  +S  L  WL+S++  L +W +
Sbjct: 6764 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ 6823

Query: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQ 5032
            QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V+S GNQLL LK+ DTATLR+ L++
Sbjct: 6824 QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSR 6883

Query: 5033 FEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS-DEDSVHSPSSA 5091
             + +WT L+T +P +QEKLHQLQM+KLPSR AI+E++SW++ +E+    DED++ +    
Sbjct: 6884 IDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943

Query: 5092 SQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
              +   LQK+K F+++++ KQ  VDFVNQS+LQ+S+ DVESKR ++T+FAE LG MN+ W
Sbjct: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003

Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              + G++  KIQ LE LLES +E EN +Q L  W E QE+RLK   +     SVQ  L D
Sbjct: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKD 7063

Query: 5212 CQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKT 5270
            CQD+E+ +  K K +++++Q+ L L ++    +     S + EL Q  +++   V QLK 
Sbjct: 7064 CQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKI 7123

Query: 5271 SMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESS 5330
             ++SVL +W  +   +D++N   +   Y +   + +  SLE ++ QV+NLQ+LQD+ E  
Sbjct: 7124 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 7183

Query: 5331 EGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389
            E S +K   +  +L   C P V E +    +  + RW  + + IA+QLQ +++LLQLW+ 
Sbjct: 7184 ERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 7243

Query: 5390 YSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQN 5449
            Y +   + A+ ++QQE +  +L   + + +   + +   +QD  +L   +   K++    
Sbjct: 7244 YKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFL 7303

Query: 5450 SSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLES 5508
              + ++L Q  ++S    +     SL Q    LE+ L  +    +  +  ++ F   LE+
Sbjct: 7304 HELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEA 7363

Query: 5509 LKGLIMHEEENL---DRLHQQE----KENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLS 5561
            L+  I+  EE L   D  H  +    +E  +     +L  ++ +PD++ LNE+  +LPL+
Sbjct: 7364 LEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLN 7423

Query: 5562 DVAVKTLQNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEALKVDV 5620
            D  +K +QN+NR W   ++   ER S+LQ   L ++ FL  CE W++ L + E+ L V++
Sbjct: 7424 DKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483

Query: 5621 ANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
            + +   LLEQQ+ +++ +AE+   Q I  S +    +LL+  ++++R EF  + + L+++
Sbjct: 7484 SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQ 7543

Query: 5681 WQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSL 5740
            WQ  ++  +QR+G +D  +RQWQ +    E L ++L + S+L  +  G     L Q R+L
Sbjct: 7544 WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL 7603

Query: 5741 IHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAE 5800
              E++ KE  F R++ +  LT+EAG++LLL+ D   + ++   ++++Q+ WK    +L E
Sbjct: 7604 FDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE 7663

Query: 5801 MIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLAS 5860
              K+    ++ W++CEK I +   +L+  K +    LP+ HE+LH E+   KELE ++ S
Sbjct: 7664 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723

Query: 5861 WTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWV 5920
            WT +L +L  +K  L+ ++  +D+ +L E++E L RQWE+LC ++++R+Q+I +RLN W 
Sbjct: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783

Query: 5921 VFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQL 5980
            VF+EKNKELC WL QME+KV Q  DI IEEMIEKL+KD  EEI +  ENK+QL+QMG++L
Sbjct: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843

Query: 5981 IKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLAR 6040
             KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET   +QQLDKNMS+LRTWLA 
Sbjct: 7844 AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 7903

Query: 6041 IESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE 6100
            IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD DACA +
Sbjct: 7904 IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7963

Query: 6101 TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAA 6160
             ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+ERTAA
Sbjct: 7964 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 8023

Query: 6161 CPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVH 6220
             P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A  LKQMVH
Sbjct: 8024 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 8083

Query: 6221 EGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD 6280
            EGNQRWDNLQ+RVT++LRRL+HF  QREEFE  R+SILVWLTEMDLQLTN+EHFSE D  
Sbjct: 8084 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8143

Query: 6281 DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV 6340
             K++QL  FQQEI+LN NKI+Q+I  GEQLI+KSEPLDA +IE+EL+EL RYCQEVFGRV
Sbjct: 8144 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 8203

Query: 6341 SRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQSLCHL 6396
             R+H++L    P  +DE + S+ E ++ED   +    W  R      S +PSS  SL   
Sbjct: 8204 ERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLA 8262

Query: 6397 VAPGHERSGCETPVSVDSIPLEWDHTGDVGGS----------SSHEEDEEGPYYSALSGK 6446
                 ERSG +TP SVDSIPLEWDH  D+             S  EE ++   +      
Sbjct: 8263 QPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAV 8322

Query: 6447 SISDGHS---WHVPDSPSCPEHHYKQMEGDRNV----PPVPPASSTPYKPPYGKLLLPPG 6499
             +S  HS     +       +    Q++   N+     P  P   T YK   G + L   
Sbjct: 8323 GLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGE 8379

Query: 6500 TDGGKEGPRVLNGNPQQEDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNL 6553
                 +  + L    ++E+  L G         Q +G  DRWE++QAQ L  +L++KQNL
Sbjct: 8380 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 8439

Query: 6554 ---QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 6610
               QQ NSD+++I  WL  TE ELE L+  +  +DIQ IEL++K+L+E+ KA D  KA++
Sbjct: 8440 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 8499

Query: 6611 VSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLS 6670
            +S+N+ S EF Q +S ES +LQ RL Q++  W+     ++ WRG L+ +LMQCQ FH++S
Sbjct: 8500 LSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS 8559

Query: 6671 QNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSL 6730
              LLL L +   R+ +    D   D   L +  ++LMQ++ EL+E Q +V  LQ++S  L
Sbjct: 8560 HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619

Query: 6731 LIKGHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD 6784
            L+   G DC+EA+EKVHVI  +LK L ++VS      + L+ +  +Q   S   S DE+D
Sbjct: 8620 LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELD 8679

Query: 6785 -SGDQPPATSVPAP-RAKQFRA---------------VRTTEGEEETESRVPGSTRPQRS 6827
             SG   P +    P R K  R                 R+T+G  ++    PG  R  R 
Sbjct: 8680 TSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRG 8739

Query: 6828 FLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 6884
            FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 8740 FLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796



 Score =  608 bits (1569), Expect = e-173
 Identities = 1245/6222 (20%), Positives = 2449/6222 (39%), Gaps = 953/6222 (15%)

Query: 25   LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
            LQ EQE  QK+ FT WINS LA+   P V+ DLF D+K G  LL LLEVLSGQ+LP ++G
Sbjct: 21   LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80

Query: 85   SNTFQCRI--NIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
                +     NI  AL FL  R IKL+NI+ TDI DG PSI+LGL+WTIIL+F IE+L  
Sbjct: 81   RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140

Query: 143  TL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESV 201
             L        S   V  + SS   SPP+K+  KV  + Q +A+KALL W Q        +
Sbjct: 141  NLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYTAGKQTGI 198

Query: 202  NVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEP 261
             V DF  SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL IPRLL+P
Sbjct: 199  EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258

Query: 262  EDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK----------- 310
            EDVDV  PDEKSIMTYVAQFL++  D      + Q   +   G+ +              
Sbjct: 259  EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318

Query: 311  --EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDEL 359
              ++++  ++  E D             KY S   F   +  ++K    ++       +L
Sbjct: 319  IFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKL 378

Query: 360  DKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQA 419
              D   ++++WD +  ++  W I+L+ +LP PL    AWL   E  + E+++  Q H + 
Sbjct: 379  SLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEET 438

Query: 420  VTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRINNI--LEK 476
               IQ K+   K L+   + H       +  +  N +P VPP++LE+M  R + +    +
Sbjct: 439  ANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFHFVSSTSE 497

Query: 477  KFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLD 536
              ++ +EF   K  +L L+   +SKL  W IKYG RESVE LL+++  FIE  +F  + +
Sbjct: 498  LHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYE 557

Query: 537  TSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQKVLACWAT 590
             ++Q   +  E+Y    G  +        +      +R     + +V+S L++V++ W  
Sbjct: 558  VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDR 617

Query: 591  YVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGS 645
            Y   +  L+A  E+ +K     E  K+  F  L  W  +H  +N+AGNFL+E  +++V  
Sbjct: 618  YGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSR 677

Query: 646  SISKELRRLNKRWRKLVSKTQ------------------------------------LE- 668
             + ++L  LN RWR+L  + +                                    LE 
Sbjct: 678  DLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEV 737

Query: 669  --MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEK 721
              MN+ L+I+     +Q  P  D    I++K      + S     E  E +    K  E+
Sbjct: 738  SFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFATMSKLKEQ 795

Query: 722  HEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESLKHLIAKG 777
              K  E ++  L    + ++L+  +E  E +  S  D     +++ T +E   +      
Sbjct: 796  LTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFK 852

Query: 778  SMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI---NVV 828
                EL+A  E+      +++   Q++    +  +VL    Q ++Q     + +   ++V
Sbjct: 853  QKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMV 912

Query: 829  KLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIIS 888
            K     K    V  +  +  K EES+ ELE  +  AQ+ L ++  P EL+ +H E     
Sbjct: 913  KKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQL 970

Query: 889  NTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGK 948
            + + L  +LKA +EL + + E  +  L+E  R +  +W+ L  E   ++  LKID+EK +
Sbjct: 971  DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNR 1030

Query: 949  LSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS 1008
               ++ +   ++++E KL+ +  ++ +IKEH   FS++G  +     ++++ ELC +LP 
Sbjct: 1031 FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPV 1090

Query: 1009 QKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP 1064
            +   ++        LK+    I+   +   E     +      S+    I+T+E +    
Sbjct: 1091 RDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGI 1150

Query: 1065 HSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIMEK--DYSA 1110
              EA    + N    ++A+E           T+ +  S   VL  +  E+  +K  D  A
Sbjct: 1151 KGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELA 1208

Query: 1111 SINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARW 1170
             ++S  +   T    +E  L N                  C+Q K    +++KN  +   
Sbjct: 1209 KLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVKNSLE--- 1246

Query: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKA 1230
               E+IS                      KE + + +  L+T  E+L  A +L+L  ++ 
Sbjct: 1247 ---ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQLLLHHQQK 1281

Query: 1231 SLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288
            +  +      + +   Q         DR ++ LR ++ ++        R E      L++
Sbjct: 1282 TKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRK 1341

Query: 1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348
               F+ +  +  +++Y  Q  G +H    S  +L++L   L   +      E +   + +
Sbjct: 1342 WERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398

Query: 1349 DTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSI 1408
              + A E  L  +NK+    L++ +AK + + +K L          +DT  E++     +
Sbjct: 1399 LVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEEDIKTMEMV 1444

Query: 1409 KLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAV 1463
            K    H +G   E      TE+ K L       N L  +   +  QIS+I +   T+  +
Sbjct: 1445 KTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV---TIQEI 1493

Query: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523
            + +  S++               L+E A S   F    E    +     +  +       
Sbjct: 1494 ESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREH 1539

Query: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEE 1583
             +CLE  G +L  L Q Q F+  L  +   ++SV   +        +     E   V +E
Sbjct: 1540 AQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATETYKVLQE 1594

Query: 1584 FNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGR 1643
              +  + ++ ++       F  +  K        +EA  +  ++ DI  + ++    L  
Sbjct: 1595 HMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652

Query: 1644 ALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSEFSRRVAE 1702
             LA W +L    +    W E+   K    ++    DR +++ ELQ+ +   +E   + + 
Sbjct: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712

Query: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQ-AKTQI 1761
               LLQ  E    +   +   + K+ H+++                E   DL Q    +I
Sbjct: 1713 YSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLPQIINKRI 1757

Query: 1762 GMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYES 1820
               +S++      D L + F+   ++    LQ    + ++++Q+         L +  + 
Sbjct: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--------LTRHKDH 1809

Query: 1821 VSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878
             +++ + K  +  LQ H +KL         D    ++   ++CF+  E    V ++ Q  
Sbjct: 1810 AAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQVVERRQLA 1866

Query: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKEL 1938
               L                + ++ H   + +   +   V     + K ES      K+L
Sbjct: 1867 LSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES--DLIEKDL 1909

Query: 1939 EDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQFESVAQLN 1997
             D+LQ    L+    +L   L+  +   K G  E           L  + E+ +++    
Sbjct: 1910 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1969

Query: 1998 NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI 2057
             S       E + + +      D+ + LL+ + +IEE      T+ +   +         
Sbjct: 1970 QS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPTR------ 2011

Query: 2058 KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLT 2117
            + +++ L V N  E ++   E      E+  LK +        + Q + + AP V + + 
Sbjct: 2012 QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAPEVDREIN 2061

Query: 2118 DISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEA 2167
             +   WD+T  L              +   + L     K L++   + +    +K +++ 
Sbjct: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL 2121

Query: 2168 GFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWL 2224
             +A  +H   + K   + K    F  K + L S LK++ S    L++     +   + WL
Sbjct: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV--DKWL 2179

Query: 2225 EI-KHLHESL---------------------------LQQLQDSVQNLDGHVR------- 2249
            ++ + L E++                           + Q+ +++ NLD H+R       
Sbjct: 2180 DVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKE 2239

Query: 2250 ---EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTL 2306
               E  +  + + +L++ +++  +   +    P  Q    + +QKL+  +    +  GTL
Sbjct: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTL 2299

Query: 2307 KKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASAKQEMECC 2356
            K   A +  V++  + +     K +   + C Q          KD++  L S +  +   
Sbjct: 2300 KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISST 2359

Query: 2357 ---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
               LNS+ +   S E +      T   ++ +A S +   TQ S   E LE+ +  +    
Sbjct: 2360 QENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHFSESMQEF 2418

Query: 2411 VEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ-----LEEIEKL 2461
             E  +  + +  A+ES   T D    E K+++LQN    LD++   +       +E + L
Sbjct: 2419 QEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAVTQEGQTL 2473

Query: 2462 YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
            Y  L  +   I    Q +     E     L       Q L +    L + +         
Sbjct: 2474 YAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLW 2530

Query: 2522 LRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKW 2581
            + + +E       + + L   K+ +     +    + K++ F+  +   ++SL  L  + 
Sbjct: 2531 IHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESLDKLSQRG 2581

Query: 2582 ENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
            + LS   H    + +L      QL    + + +  ++K     V   E   L   +Q   
Sbjct: 2582 QLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQ--- 2634

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKE- 2698
             S+    + +Q RL   E   G++  +       +      ++KG+ E+++    G+ E 
Sbjct: 2635 -SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNMAIGKGEQ 2690

Query: 2699 --KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPL 2756
              + + ++G   ++ Q ETL+                       +WA  +   ++    L
Sbjct: 2691 ALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSSVHAQSTL 2728

Query: 2757 LPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDLNNTLEDL 2811
              + ++SQ        +  + R+  +E   E V  K+     P     E   L + L+ +
Sbjct: 2729 --ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSI 2779

Query: 2812 RNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEA 2868
             ++   +   + +   +S++L  K E+ S  F    + +L  Q ++ + + + +    E 
Sbjct: 2780 LSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKEKMRKVEE 2837

Query: 2869 ELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKNLKIRTNR 2926
             +K H + L+A  +    + S     L   +++  + +  ++    +++ + + +I  +R
Sbjct: 2838 IVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASR 2896

Query: 2927 IQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEVNKGVKEE 2980
            + R +++   EV+       C   H +  AL+ +     DS+ + +  L   V++    E
Sbjct: 2897 LSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955

Query: 2981 ------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQLQTQVFE 3026
                  +  L+  L      +      L +L+ K   + I   W   Q  LD LQ +   
Sbjct: 2956 QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQ-KAEP 3014

Query: 3027 KEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAPDSSPESR 3080
            + ++L+ ++ +L  F  +     GK   L+ +   + LQ  K    +  +         R
Sbjct: 3015 RTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFR 3074

Query: 3081 RLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNM 3140
                 +++ +I  AKC   +I + ++E  T     K +E L    N +    +      +
Sbjct: 3075 DFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNMMLSKGEL 3130

Query: 3141 VLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDNCEAFQEQ 3198
            +  L  KE   K  Q K+  +        S L Q    L NL+I+ +++ + + E  Q+ 
Sbjct: 3131 LSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVSAEPIQD- 3187

Query: 3199 VWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYE-N 3257
             W        ++  EK   E+S+   D+  K RE + LQ  L              YE  
Sbjct: 3188 -W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI---------HCYEPQ 3229

Query: 3258 LTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLT-EK 3316
            L R KE   +  E   + ++                     +  +L S    + +LT EK
Sbjct: 3230 LNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLALSNLTKEK 3271

Query: 3317 LGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRKMEEDIYT 3373
            +               L  +V++++      K  +   T+A   L++Y C+   ++ +  
Sbjct: 3272 VS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPTSDKSVLD 3317

Query: 3374 NLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433
            +             +L L   EAL  ++Q K +   +I T+ E +          L+ T 
Sbjct: 3318 S------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV----------LQNTS 3352

Query: 3434 NDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEEL 3492
             +GI  + + + ++ + W SLL A    +   E    +W    + + + +  +D+++  L
Sbjct: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412

Query: 3493 PEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVP 3552
             E        +  + +EL D     G    K +LL   +L     ++ + E  GA  T  
Sbjct: 3413 NE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVKGAGMTE- 3458

Query: 3553 AFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQ 3612
                +T ++      LQ +Q+    +Q   +E  + +++++ L   +Q+   +F+    Q
Sbjct: 3459 --HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQ 3510

Query: 3613 DHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
            +  EK +Q+  L+      + T  ++ E L++  +E   ++ + + ++ +     +   +
Sbjct: 3511 EQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568

Query: 3673 EKISNEVLKSSPSY-------------------AMRRKIEEINNGLHNVEKML-----QQ 3708
            ++    + +   +Y                    M +K ++++  L   E+ +     +Q
Sbjct: 3569 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQ 3628

Query: 3709 KSKNIEKAQEIQKKMW-DELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQ 3767
             ++  ++ Q  Q K W +E+  +  ++ E+ +  Q+I+++    ++       +   +YQ
Sbjct: 3629 SNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQ 3687

Query: 3768 QVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHA 3824
             +  +   +   L +    +EE    L S   W  +T     N A   D + T  +    
Sbjct: 3688 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3747

Query: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIME 3880
             T+++ L+D E+ H+LL S   +  + ++ +    E + L + I +   Q+  L   + +
Sbjct: 3748 KTLEVLLKDMEKGHSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806

Query: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
                +++          + K++ + +++ + IL   E     P+  L   +  L   + +
Sbjct: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSL 3862

Query: 3941 KKTIAEIVSYQVELR-LPQTGMKPLPVFQ------RTNQLLQDIKLLENVTQEQNELLKV 3993
            ++T   ++S++  ++ + + G   L + Q      + +QL  D + L ++ +E    L+ 
Sbjct: 3863 QQT---VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEA 3919

Query: 3994 VIKQTNEWDEEIENLKQILNNYSAQF---------SLEHMSPDQADKLPQLQGEIERMEK 4044
             +K   +++ E++ +++ L   S +          SLE ++   A     ++ EI   E 
Sbjct: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME-EIAGFED 3978

Query: 4045 QILSLNQRKEDLLVDLKATVL------NLHQHLKQEQEGVERDRLPAVTSEEGGVAER-- 4096
            ++ +L Q K D L+   A  L      N+H HL+       +D   A+ S     A+R  
Sbjct: 3979 RLNNL-QMKGDTLIGQCADHLQAKLKQNVHAHLQG-----TKDSYSAICS----TAQRMY 4028

Query: 4097 DASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRAS 4156
             + E +L +  S       ++ +++            EPSPQ   S  +  K ++  RA 
Sbjct: 4029 QSLEHELQKHVSR------QDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL 4082

Query: 4157 SSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDS 4216
                    +    +    N+  +    D   TEQ  E  L            ++A  L  
Sbjct: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL------------VQAQNL-- 4128

Query: 4217 SDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQV 4271
               QG  E +  K+       +  + L   K + +ELEL     N+A    +   D  + 
Sbjct: 4129 --TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELEL-----NIAQNMVSQVKDFVKK 4181

Query: 4272 LEQQLVGCQAMLTEI----------EHK-VAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320
            L+ +      ++ ++          EHK +  L +   D     N       E L     
Sbjct: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRD 4241

Query: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380
               C +  V++ L++  +E  +       S   H EAL+ + L+     + ER       
Sbjct: 4242 YHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALA-----LQERKYAIEDL 4295

Query: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440
              Q+Q+++E   ++ K+ +K    + ++ W Q      D  +     +  +  E +V  S
Sbjct: 4296 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL----EDLIKRKIQVSVTNLEELNVVQS 4351

Query: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500
                + Q   +W     E    I   L Q   P ++ N+                     
Sbjct: 4352 ----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQNL--------------------- 4383

Query: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560
                L D     S L+ ++ + +    + D+ + +L L   Q +       +       D
Sbjct: 4384 ----LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439

Query: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620
              GQ+  Y         L  ALS+K   L+       +      +      +CL     +
Sbjct: 4440 LVGQRRKY---------LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVS 4490

Query: 4621 AVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSKTSLQQSLNEISGQSVAEQLQKAD 4676
               ++ KS +A L   ++YQNE+  L+ Q   L+K  T  +Q  +E+ G+   ++LQ   
Sbjct: 4491 KQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEVT--EQEKSEVLGK--LQELQ--S 4541

Query: 4677 AYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVT 4736
             Y   L+    R+ +L            L+   +  ED  D     L+            
Sbjct: 4542 VYDSVLQKCSHRLQELEKN---------LVSRKHFKED-FDKACHWLK------------ 4579

Query: 4737 ESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
              Q D +    + L+    E   H  L + ++ +    + EN           +L +Q  
Sbjct: 4580 --QADIVTFPEINLMNESSE--LHTQLAKYQNILEQSPEYENL----------LLTLQRT 4625

Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
               ILPSL +   ++ +E+      L    RQ  + +     K+ +  E   + ++   +
Sbjct: 4626 GQTILPSLNEVDHSYLSEK------LNALPRQFNVIVALAKDKFYKVQEAILARKEYASL 4679

Query: 4857 LISTLPSVSLVEETEERL--------VERISFYQQIKRNIGGKHARLYQT---LNEGKQL 4905
            +  T  S+S +E    R+        VE     Q   R I  + A L +    LN+ K+ 
Sbjct: 4680 IELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEG 4739

Query: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQH 4965
              S   P    ++  L   +  L ++ +  +  L+        + +   QL + L+S + 
Sbjct: 4740 FRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799

Query: 4966 TLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT 5025
              +   E++L   + L    S   +        D    LK   I + +   HL       
Sbjct: 4800 EQSKVNEETLPAEEKLKMYHSLAGSL------QDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853

Query: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSV 5085
             R  +  ++ +  +L + + +   +     ++ +  +  ++  + W+  V+ + S    V
Sbjct: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELS--GPV 4911

Query: 5086 HSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLG 5145
            +   +   ++  ++K +  + E+     I++ ++    +  T   ++K     +    L 
Sbjct: 4912 YLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFT---KAKELISADLEHSLA 4968

Query: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205
            E++     +   L  +   L ++           Q  N+WLE  +E L+       V S 
Sbjct: 4969 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA 5028

Query: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQV 5265
            ++ L    +  +        L+EL     TL+    PL++ T    ++L QK +S+  + 
Sbjct: 5029 EENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTGK--EDLEQKVASLELRS 5082

Query: 5266 NQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
             ++          +Q    +W  Y +  +EV  +M        E S     S      ++
Sbjct: 5083 QRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142

Query: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNT-HKRWTQVNQAIADQ 5376
               ++L     S       L+E   +L+      ++    +   T  +RWT++     DQ
Sbjct: 5143 SEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5202

Query: 5377 LQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436
             +  +  +  W  ++N   +A   + Q + K    +    S   L  +L      + EL+
Sbjct: 5203 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5262

Query: 5437 HDVQKTKEAFLQNSSVLD--RLPQPAESSTHM-----LLPGPLHSLQRAAYLEKMLLVKA 5489
                       Q  S+L     P P E    M     +    L+  ++     K++  + 
Sbjct: 5263 QQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQEL 5322

Query: 5490 NEFEFVLSQFK------------------DFGVRLESLKGLIMHEEENLDRLHQQEKENP 5531
             + E V +Q                    +   +LE L+ L+     +   + +  +E  
Sbjct: 5323 KDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK 5382

Query: 5532 DSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQG 5591
            + +L     L ++      L EV+L L + D     +Q+  ++  ++ AT+ E   ++Q 
Sbjct: 5383 EKYLGLYTILPSELS--LQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQIQ- 5435

Query: 5592 IGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK--------TYKMLEAEVSI 5643
                        K  + L  I   LK    N +    +Q+           K++E + ++
Sbjct: 5436 ------------KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483

Query: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQ 5703
             +     ++ Q+ QL        +P    +  KLT+  Q  ++    R   ++      +
Sbjct: 5484 QK-----FLEQNGQL-------GKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5530

Query: 5704 DFTTSVENLFRFLTDTSHLL-------SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRT 5756
            ++   +E + +++     L        SA + +E++ L+QT  L+ E  +KEI  +    
Sbjct: 5531 EYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQT--LLEE--SKEIDSELEAM 5586

Query: 5757 TCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCE 5816
            T        EKL   T +   E + +++++L    +++   +   ++  Q   +   + E
Sbjct: 5587 T--------EKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638

Query: 5817 KKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKELIKELE 5855
             ++K+L++ L+  +A    P      L E L + + L+ E+E
Sbjct: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEME 5680



 Score =  117 bits (292), Expect = 5e-25
 Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)

Query: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
            Y+  +K    +LI     +Q+   +I        + Q +    QK    + +  + + ++
Sbjct: 1237 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1296

Query: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
            A+ + +GE   LP    +E+ KLE  LD   G+ R+R  +     VT  + +        
Sbjct: 1297 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1351

Query: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
            +V+ + +   +H       S  +L +++E  K F ++   + + +QA +    A  +P  
Sbjct: 1352 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1409

Query: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
             QN++    +  +   +VK LE+   +    ++ +  KW+ F  N+ +L       EK+L
Sbjct: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469

Query: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
              L ++  ++ +        ++E E +L        E  SF Q +      +  A+L Q 
Sbjct: 1470 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1529

Query: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
               G++L     C  LEG I       LS  +K +  L ++Q       S +   D+L  
Sbjct: 1530 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1577

Query: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
             ++        +K  ++ +++ Q L+++ S I  F   +++V  + S      ++  Q  
Sbjct: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637

Query: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
              L   KE  TA   L A   + E++ +  +T L   + K    +M+    R  +   + 
Sbjct: 1638 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1697

Query: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
             +  ++++   + S +S         LLQ                  + +SL  +++ D 
Sbjct: 1698 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1730

Query: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
                 +      HL +++ +W  +  ++N++I  L+ ++    + +  +   + W++   
Sbjct: 1731 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785

Query: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
              L+T  +  S++  Q  L   +D   ++  K   L  L+     L S      + LL+ 
Sbjct: 1786 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844

Query: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
             A    +LF++ S V+ +     + +   LQ       +  ++   T+     M  ++  
Sbjct: 1845 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1903

Query: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            ++  + L   ++N ++L+  A S +G   K Q  +             I    Q T  R 
Sbjct: 1904 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1950

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            T     +  ++++ Q+LL                 KQ EA    LA +  +  +  E L 
Sbjct: 1951 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1991

Query: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
             +++DI+E    +   + T++A  Q   V ++L     S  H L         +A  + +
Sbjct: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2047

Query: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
              +  A E +  +++ +   V  +  K LI HE +       +L R +Q  K      L 
Sbjct: 2048 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2103

Query: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
            +  ++      I+   ++       + A   +    +     T+      SEL+ I  ++
Sbjct: 2104 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2163

Query: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
              L         +KW+ + EK+EE    L+V ++                 N +P++ E 
Sbjct: 2164 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2223

Query: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
                      ++  K  E+EV       +   ++   L + T+ +E  P+     + L  
Sbjct: 2224 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2283

Query: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
            + ++A +     KG +       +DFT     + +F+ D +         L++  + +  
Sbjct: 2284 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2336

Query: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
             +L + + +  EL++++ +     +   + C     A  + L   +T  +K  E+V +  
Sbjct: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2396

Query: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
            S+ Q S ++ +E   +E +++FQ          K+  +     +VL+A+       LH D
Sbjct: 2397 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2448

Query: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
            L N  + + + +  L + TQ   E QT+ A L++ +    V  ++EQI   + +++    
Sbjct: 2449 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2501

Query: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
            +    KQ ++D  +    F +++++L  W+ +ME +   T ++   +     +K+ + ++
Sbjct: 2502 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2560

Query: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
             +F    L  ++  D+L +     S +   A  + +L +++    Q+L  +   +++  +
Sbjct: 2561 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2620

Query: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
                  + L++ + ++  W+  I+  L+      +     ++KRL++ QD+     +   
Sbjct: 2621 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2679

Query: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
             +       +  L  S    N+     IQ    +L   W +I + S+  +  +E     W
Sbjct: 2680 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2735

Query: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
              +++  ++ E W++S ++    P   +       VL    +  L   E   R +H  + 
Sbjct: 2736 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795

Query: 6192 QLELINKQYRRLARENRTDTA 6212
            +     + Y +   E+  DTA
Sbjct: 2796 K---SRELYEKTEDESFKDTA 2813



 Score =  105 bits (262), Expect = 2e-21
 Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)

Query: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
            +   K   T L ++ +  SN        E    +L+    EL     +     E++L+  
Sbjct: 1211 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1266

Query: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
             L+  +     +H++    + K++     D +  + +A    G   +   E    L+  L
Sbjct: 1267 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1321

Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
            +  + +   + + ++  L     ++   + +   L ++ +S ++ L+  S +S++ +L++
Sbjct: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1381

Query: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
               ++   E+   +   L  E   + L             ++ ++V KLED L+      
Sbjct: 1382 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1441

Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
             M++ ++    S F T S            V I +++     L+ + S  A+  QI   K
Sbjct: 1442 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1487

Query: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
            V  Q++   ++ ++ ++  +      +          ++T+++   E+ R+    L+   
Sbjct: 1488 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1547

Query: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
               L + ++F+EN   +++ +    + L   +   S   ET + L E +   Q ++    
Sbjct: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1603

Query: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
               + +       +++V   SC +   + A L++Q+  + ++       L+ LL H    
Sbjct: 1604 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1660

Query: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
             ++      WLE  +   +      +++S D   +   +        EV  ++S  + ++
Sbjct: 1661 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1717

Query: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
             +   L  +  + D   ++  L Q +++W      LP I  K        +   +   E+
Sbjct: 1718 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1773

Query: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
            +     W+     E QT+ E S+     A      L +HK+   E++ K+  +  +   L
Sbjct: 1774 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1827

Query: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
             +L +                     +  S+  ER + A  HL E  +    + G+L + 
Sbjct: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887

Query: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
             Q +E                    L++    E+    L+  L   +  LK   + Q+  
Sbjct: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947

Query: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
               +  +L  + + I+N L  K     AL  LK+++   +   +  +ED   R D+   K
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007

Query: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
                       + + Q++ Q  ++++QL DE+N       +  + +K +         +V
Sbjct: 2008 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2056

Query: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
            +       E    E +W+  + +I + +G C  + +++ E        +  +  A++  L
Sbjct: 2057 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2102

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
            + A S++       +      A  K + AK +       L N +  G +L +E+      
Sbjct: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162

Query: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
            D   ++ D++ T + +L  S  L    DRL                 E  ++  +P    
Sbjct: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222

Query: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
            ++     +L    L+K  EFE   S+ K+  +RLE L   +     +L  L +  +  PD
Sbjct: 2223 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2273

Query: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
              L  + A   Q   +EH  E++   K  L D   ++ Q     N    W      +L  
Sbjct: 2274 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329

Query: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
            C++      NE     CE  K ++ ++K  ++ + +++++   L    + Y   E E S+
Sbjct: 2330 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2378

Query: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
             + +           QL   T+   +      FS+    +Q    G +        R GD
Sbjct: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2438

Query: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
               L  +  D    ++N+   ++D    L AV  QE  +LY      H  K      Q +
Sbjct: 2439 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2488

Query: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
             T      +A  K  L  D +  +     +   +D  + +   + EM ++F +  E   +
Sbjct: 2489 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2545

Query: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
             ++ I E K+ +  ++    + L   E  + L    +L+ E         +   +L T  
Sbjct: 2546 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2605

Query: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
             +L R        + KE++            +VA+++ E            E  + +  W
Sbjct: 2606 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2639

Query: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
            +  +++++    + +  ++ +EK      + + +  E +++L      G+Q +++SNK  
Sbjct: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2699

Query: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
               I  +L  + + W    D++ S V       + I Q +   +  + L  W+  ++ ++
Sbjct: 2700 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756

Query: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
              P+        + Q  L E+  L   ++   +  E        L+  S     +TE +S
Sbjct: 2757 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2808

Query: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
             + T +  L  ++ +I  ++ E+  K+EE  +    +LD    F DWL SA+      + 
Sbjct: 2809 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2868

Query: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
                 ++ +++L + +     R+I   RL+++E +  + ++    +  +      Q +  
Sbjct: 2869 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2928

Query: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
              ++W++        L+  V+ +    + F+ Q  + E   E     L     QLT +E 
Sbjct: 2929 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2987

Query: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
                + D+++ +     QEI                 +QK+EP    L + +L EL R+ 
Sbjct: 2988 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3030

Query: 6334 QEV 6336
            +++
Sbjct: 3031 RDL 3033



 Score =  104 bits (260), Expect = 3e-21
 Identities = 305/1616 (18%), Positives = 602/1616 (37%), Gaps = 271/1616 (16%)

Query: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLV--ASVSCPELEGQIAKLEE-- 4923
            E  E+ L   +SF +  K     ++   YQ L +  ++   A  S  E E  +  + E  
Sbjct: 534  ESVEQLLQNYVSFIENSK--FFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETT 591

Query: 4924 -QWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDL- 4981
             QW +L+ ++      L+ ++ +   Y      L  WLE ++  LN    QS N  +D  
Sbjct: 592  AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLN----QSENAKKDFF 647

Query: 4982 ---------DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL-------------- 5018
                      T  ++  NF   + +      LK  ++ +  +   L              
Sbjct: 648  RNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMD 707

Query: 5019 ----KETD-TATLRASLAQFEQKWT-----------MLITQLPDIQEKLHQLQMEKLPSR 5062
                + TD   TL A   +  +K +           +LI  L DI++++  +  +     
Sbjct: 708  RMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY---- 763

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
            K IT+     + +  ++  E+     ++ S++K  L K KE    + Y+       +Q L
Sbjct: 764  KIITKTA---HLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYE-------SQQL 813

Query: 5123 LQLSTCDVESKRYERTEFAEHLGEMN----------------RQWHRVHGMLNRKIQHLE 5166
            L      +E    + T F + LG++N                +Q H+         +   
Sbjct: 814  L----IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTL 869

Query: 5167 QLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKAL 5226
             L+E  ++S  K   L+N L+  ++     Q  +  ++ Q ++    D +  +   S+ +
Sbjct: 870  TLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLM 929

Query: 5227 DELKQSYLTLESGAVPLLEDTASRID--ELFQKRSSVLTQVNQ----------------- 5267
             + ++S   LE       E    + D  EL ++ +   +Q++Q                 
Sbjct: 930  KKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDIL 989

Query: 5268 -------LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
                   L+ +++ + ++WK    L  E     +     +E ++  + S+E  R +++  
Sbjct: 990  PEQEQQGLQEAVRKLHKQWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRE 1045

Query: 5321 QSLQDEAESSEGSWEKLQE--VIGKLKG---LCPSVAEIIEEKCQNT------------- 5362
              L  +    EGS + ++E  V    KG   LC    ++IEE C                
Sbjct: 1046 TKLMPQ----EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTC 1101

Query: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA 5422
            H    ++  AI    +K       WK Y++   E ++ +   E + + +   ++   N  
Sbjct: 1102 HVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHG 1161

Query: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLE 5482
            E+     + ++E+++ V K  E     S +  RL    E S+          L + +   
Sbjct: 1162 EVK----RAVEEIRNGVTKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSF 1214

Query: 5483 KMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALT 5542
            K L+   +E E +LS F D        K ++ +  E L    ++ +E  +  L+      
Sbjct: 1215 KALVTLLSEVEKMLSNFGD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFE 1270

Query: 5543 AQSPDIEHLNEVS-LKLPLSDVAVKTLQNMNRQW------------IRATATALERCSEL 5589
            AQ   + H  +   +     DV  +  Q    +             + +T   LER  E 
Sbjct: 1271 AQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRER 1330

Query: 5590 QGIGLN------EKFLYCCEKWIQLLEKI----EEALKVDVANSLPELLEQQKTYKM--- 5636
            Q   +       E+F    E  ++ L +     E  L      SL   LEQ K +     
Sbjct: 1331 QERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTE 1390

Query: 5637 ---LEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKG 5693
               ++AE  + +        Q+ QLL     +       +  KL D  +  ++ +   K 
Sbjct: 1391 SIAVQAENLVKEASEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK- 1445

Query: 5694 DVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNKE-- 5748
                   +W  F ++ E L  ++T+    L+A++         + Q +  I E+++K   
Sbjct: 1446 ------TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS 1499

Query: 5749 -IHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQS 5807
             +  +    + A  +  GE   +   L      G    +L++  + +E  +   + Q Q 
Sbjct: 1500 IVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGE---ELREHAQCLEGTILGHLSQQQK 1556

Query: 5808 TVETWDQCEKKIKELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
              E   + ++ + E + +L V +K  S     E ++ L    +L + LE        +L 
Sbjct: 1557 FEENLRKIQQSVSEFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLS 1606

Query: 5867 ELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKN 5926
               T  +   R V+  D  V  ++   L +Q+ED+  R   R+  +E+ L  W    ++ 
Sbjct: 1607 SAITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1664

Query: 5927 KELCAWLVQMENKVLQTA-DISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMG 5977
                 WL + E K      DIS +        ++I+ LQ + + + + +S+    L Q+ 
Sbjct: 1665 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK----LLQLK 1720

Query: 5978 DQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTW 6037
            + L   ++K     +   L ++++RW+ L  +I  R+  L+   A  QQ D+ + +   W
Sbjct: 1721 ESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780

Query: 6038 LARIESELSKPVVYDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNI 6086
            +    SEL       + D Q           E++ +  E Q LQ     H A + S+   
Sbjct: 1781 IKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRA 1836

Query: 6087 CDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYS 6146
             D+ L    A   E      ++ ++ ++RR   +  ++               +FL  ++
Sbjct: 1837 EDLHLLQGKA---EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHA 1878

Query: 6147 RFEDWLKSAERTAACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYR 6201
                 L+   +T    NS     S+++     + L+  +A +         L       +
Sbjct: 1879 SLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLK 1938

Query: 6202 RLARENRTDTASRLKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESI 6257
              + E RT   +   Q+  E  +R  NL    Q    A+    + F +Q+EE   + E I
Sbjct: 1939 IGSSEQRTSCRATADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI 1997

Query: 6258 LVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
                 E       ++  +      ++R  N  + E+  + +++  L    +Q+ QK
Sbjct: 1998 -----EERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048



 Score = 90.9 bits (224), Expect = 4e-17
 Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)

Query: 713  NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
            NQN+    ++E+  ++      TGQ K+A D + ++   E    E + +LD+        
Sbjct: 6582 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6637

Query: 762  ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
                   +T   + +   + K + F  ELMA++  +L+   +        +++L T    
Sbjct: 6638 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6694

Query: 815  KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
               + +   Q+ VV+       L + + D  +D     +  +  L  Y  +  Q+L   +
Sbjct: 6695 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6754

Query: 873  ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
                  S  +L S+  +     +SNT  ++K L  +E +  + T       + +S D+  
Sbjct: 6755 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6809

Query: 925  KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
              +S    L  + QQ + +  E   + D++   L+  K+++ +  L             +
Sbjct: 6810 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6869

Query: 968  RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
            ++  T  L  E     S+    L  +    E L +L  ++LPS+ +  EV     L+++ 
Sbjct: 6870 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929

Query: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
             QK E  +K +     IH  LQ   G     N   +T            +   +S     
Sbjct: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989

Query: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
            T+ A +         +L+ L  E I        +  LLE +  Y        +NN   + 
Sbjct: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 7035

Query: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
            + F ++E R          + +Q  L D Q +++   A+ KE E I       + + K+ 
Sbjct: 7036 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7095

Query: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
                   TL+E   +    L+  +  L+  L+ VL      K +     S L   + ++ 
Sbjct: 7096 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154

Query: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
             F L+    +A ++   +L+N+QD + KQ     +     N +LKE HP     + N + 
Sbjct: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214

Query: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
            +   ++  +   +     + KAL       +D+     +     E  T+    +A++  +
Sbjct: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274

Query: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
            A +   T      +  L+K      D    + ++  +  ++  D S  + + +  + LS+
Sbjct: 7275 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7331

Query: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
             H   +++   ++   L+A +       K+++ +++ I +    +  +DP+         
Sbjct: 7332 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7384

Query: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
             L  + + ++E + +      MA  L    + G    +N ++ +    L  +   + ++ 
Sbjct: 7385 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7444

Query: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
             E+  ++   L Q+Q F    ++ +  L+Q E+ + + +  +Y   ++L ++    E+ +
Sbjct: 7445 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7501

Query: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
             E     ++   ++ +  + Q  L + +  +   F  +  ++ ++W  +  + +     +
Sbjct: 7502 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7558

Query: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
               +  W +   +   + +W  +             + L Q  T  D  + KE++ + +Q
Sbjct: 7559 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7618

Query: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
             +   +    +   L   S     LQ   + I  K +     L  +          A L 
Sbjct: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7672

Query: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
            +D ++ +  I  +   L+      S  +    EE+  + ++ K     LEN +G  T +L
Sbjct: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7728

Query: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
            ++L    +++S         + N +  +LQ  + +L +          +  N+W  FS  
Sbjct: 7729 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7788

Query: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
               L E     E+K S      +E+ ++KL      E    + +KI+     L+ + + L
Sbjct: 7789 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7843

Query: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
             KA  +   S +   E++L K+         +  AR K+L+++L  + +L  +  +LR W
Sbjct: 7844 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7900

Query: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
            L + E                                          +E  + I+  +C 
Sbjct: 7901 LAHIE------------------------------------------SELAKPIVYDSCN 7918

Query: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
             +  Q  L +  E++ + +   T   S  +L   ++H            +  +    L+ 
Sbjct: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7978

Query: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
            R    + I  +  E   +IE   +        L QK L D S    W  +    + + S 
Sbjct: 7979 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 8027

Query: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
                   G  Y  +KE       ELKK +    A Q  + E   QL++  K  ++     
Sbjct: 8028 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 8070

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
              D    LK++  +GN             + W  ++    S+L++L+  +   +      
Sbjct: 8071 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117

Query: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
            DS  V +T+++  L N   E  S  D       V+ K+++L+  +  +SL    +++I+A
Sbjct: 8118 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8168

Query: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
              + + + +  +   II++++  L+                   C     + +R  +K  
Sbjct: 8169 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8211

Query: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
            +  LP  E    SD +   ++SAA+  L   W + + DS +    S  LSL+  + +++ 
Sbjct: 8212 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8268

Query: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
               R     + + PLE D             L   LE+  +   P E  E   + +    
Sbjct: 8269 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8317

Query: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
            +   +G S  H   L   +  L K  +     ++  +  + +   +   L T  +     
Sbjct: 8318 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 8376

Query: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
              +  + +D +K+    +++E++SL         ++ H T       E+Q   +   WE 
Sbjct: 8377 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 8423

Query: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
            ++ Q   K     Q + ++ +F + +N +     DTE  L+Q Q+           LQ+ 
Sbjct: 8424 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 8483

Query: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
            +LK  ++   ++  I L+ +L + +        QA+         KE ++L+D ++ +  
Sbjct: 8484 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 8529

Query: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
            +W+     LE      ++ + +C   ++M    +L  +N+    N  +P+   L  +IL 
Sbjct: 8530 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 8589

Query: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
               K   ++ H+ +L  Q  V SL +        L   EG+D     E +    N+ ++L
Sbjct: 8590 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 8645

Query: 2819 VLKSTQRSQQLEFKLEERSN 2838
            + + ++  ++LE  L+  S+
Sbjct: 8646 LKEVSRHIKELEKLLDVSSS 8665



 Score = 67.0 bits (162), Expect = 6e-10
 Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)

Query: 311  EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
            + L+ L+K  E +    + N L + +++  E+  S   V+S  R+L +           W
Sbjct: 7065 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7111

Query: 371  DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
              LDH +   KI L   L        A+ +    LM+   S S+    + ++  +Q ++ 
Sbjct: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7171

Query: 429  LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
              ++L D  E     L     +T +   E H P+     N L+E+  R NN+LE+    +
Sbjct: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7227

Query: 482  LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
             E       +L L    K  SK     ++     + ELL    +K I + E    + T  
Sbjct: 7228 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7283

Query: 540  QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
            Q C ++ K L                      A     I    + +   +C   + +   
Sbjct: 7284 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343

Query: 578  KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
            +++LQ  +  + T+ ++L  L A   E                 T +E ++E+  + L  
Sbjct: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403

Query: 621  WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
             ++  +   LNE G  L     ++      K ++ LN+ W  + S+T    +       Q
Sbjct: 7404 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7457

Query: 679  DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
             Q   +     +    +  V+    ++VE+  NY   ++    HE    E   + ++   
Sbjct: 7458 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7513

Query: 738  ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
               D ++L+ Q ++                W+       + + ++D    Q      M E
Sbjct: 7514 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7573

Query: 769  SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
             L+  + + S                   +FDE+  + +  L+     I + E+ + +L 
Sbjct: 7574 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7633

Query: 810  T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
            +        LQA++ E +EK +   ++L    K L  +  D +   K + +S ++L ++ 
Sbjct: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693

Query: 862  MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
             +  Q L          ++  K  E  + S T  L +     + L   ++ D    L E+
Sbjct: 7694 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7753

Query: 919  SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
               +  +WE L H+LSL  QQ+        +  EK K L + + ++E ++++   ++   
Sbjct: 7754 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7813

Query: 971  RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
              + L K++  E   ++E  + QL    E L +   E  + + + ++ ++   ++  ++ 
Sbjct: 7814 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872

Query: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
            +   +K   E  + +Q      S     +   E+    P      +SE    K + Q   
Sbjct: 7873 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7932

Query: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
            ++ +E      +ASVL  L E  + + D  A      SI       D  +R+I    +E 
Sbjct: 7933 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7990

Query: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
             L+  +      +   D+S  ED  +SS    A  +   VI        K+FE    ++ 
Sbjct: 7991 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 8050

Query: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
              +     I K +    R+   +    L+  +   N R ++L+  +  +L          
Sbjct: 8051 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8110

Query: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
                  + S+L+  +++ L    I+ F   D     + L+  Q  I+       ++   G
Sbjct: 8111 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8170

Query: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
              ++++  P D   ++  + + +   + +  RV+R    L                    
Sbjct: 8171 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8230

Query: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
               AL D     R+A   LS +P ++LS S  Q  +    + ++    +  +  +  H  
Sbjct: 8231 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 8289

Query: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
               + L+ +   A   +D   ++  D +   ++ LS  H   ++ +  +  K L+   F+
Sbjct: 8290 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 8348

Query: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
                      +Q   + I  K PT P +    K  ++L       +D  +  +  L+E  
Sbjct: 8349 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 8398

Query: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
             SLP F +    +   Q    +  WE    L  + L +  R+ + L+++Q F S L +  
Sbjct: 8399 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8453

Query: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
              L   EE +  LQ     +  L   I  IE+  ++  E  + VD    +  ++      
Sbjct: 8454 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 8505

Query: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
                  P F +            ++++ D  + L +    WD++ +L   ++EW     +
Sbjct: 8506 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 8547

Query: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
              +Q    H+++       E+ +R K E+      +  +   +  +++ +I+  L  S++
Sbjct: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 8607

Query: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
             +  LQ M   +L   E    CL  +   H +      L+  L +    I   E LL   
Sbjct: 8608 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 8663

Query: 1772 SPSDSLEIFTKLEEI 1786
            S    L  ++  +E+
Sbjct: 8664 SSQQDLSSWSSADEL 8678



 Score = 66.6 bits (161), Expect = 8e-10
 Identities = 690/3682 (18%), Positives = 1394/3682 (37%), Gaps = 539/3682 (14%)

Query: 706  VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
            V L E  +Q  K G    K           + +T    VA+D EK++   V+ W      
Sbjct: 5160 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219

Query: 756  VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
            V    ++   +++ L    A+ +   EL+   E  D   ++++    Q+S   +L     
Sbjct: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5276

Query: 814  AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
            + +Q+           L+  +  + D    L+++ K++ + K ++  +   + +  Q  S
Sbjct: 5277 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5334

Query: 874  PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
                + + KE L  + T  +   L+ ++ L    T   ++I+   EE+       +  L 
Sbjct: 5335 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5393

Query: 931  HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
             ELSL + ++ +D++ + ++ D I ++E+     ++L R+ +   K L        ++  
Sbjct: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5453

Query: 988  CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
             + Q     +VL    EEL    S+      L + +  +++ L+   ++   L    G  
Sbjct: 5454 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504

Query: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
            T  ++ TI  +ENR    +  A   +  N+         EKA      T+ ++ AS LR 
Sbjct: 5505 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5564

Query: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
              +  ++++E  K+  + + ++ E+      +   +      +  ++   E +     ++
Sbjct: 5565 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5621

Query: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
             +L +LQ    +      E + +   LE     +  P V   R +LKE+    Q  L + 
Sbjct: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5678

Query: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
            MESL+  ++ V         LC S L + +  +    L  A  R+ +    +Q +  +Q 
Sbjct: 5679 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5729

Query: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
              CN                    MQ  +++Y+   + M H  Q  E   + +ED     
Sbjct: 5730 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5763

Query: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
                ++   + +L A  ++  +E    +K  + +I  +  K K L    K   M     E
Sbjct: 5764 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820

Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
                      LD   +     H   V       + LL     ++ E     +   S+IS 
Sbjct: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5875

Query: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
                + P     T  +V         L     + +  K H    A S   ++ G E +  
Sbjct: 5876 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5934

Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
             +  +    WE  K +++E        LE  ++YQ+    ++T ++  E  + L  S   
Sbjct: 5935 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5992

Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA-----N 1621
              + + ++AE + + +E    L + D+IN++  +L   L   ++ E  P E+ A      
Sbjct: 5993 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQLALQSTLT 6048

Query: 1622 IIVDRWLDI-----------NEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKME 1670
            ++ +R   I            EK  D  E   +  AL  +     + +D W       ++
Sbjct: 6049 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL-QRYRCEADELDSWLLSTKATLD 6107

Query: 1671 LHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHV 1730
                  ++   ++ +L   +    E  ++V  +  L     +  E  ++E     K E  
Sbjct: 6108 TALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL----SVHNENLLLEGKAHTKDEAE 6163

Query: 1731 QKCLTGESNCHALSGSTAELREDLDQAKTQIGMT----ESLLKALSPSDSLEIFTKLEEI 1786
            Q  L G+     L GS  EL+  L   +  +  T    E     L+ + S  +   L + 
Sbjct: 6164 Q--LAGK--LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQA 6219

Query: 1787 QQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLND---- 1842
            +    QQ+ S +  + +   L  EL+E K    SV+     ++ ++Q   ++   D    
Sbjct: 6220 RTTWTQQRQSSLQQQKE---LEQELAEQKSLLRSVAS--RGEEILIQHSAAETSGDAGEK 6274

Query: 1843 -----QCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
                 Q        S+ +  ++  +ES   + S +QKL  L + L  E       + + +
Sbjct: 6275 PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL--LQNVLEQEQEQVLYSRPNRL 6332

Query: 1898 LKHV---KKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRN 1954
            L  V   K  +P      + S L G     E++ S     AK     L+Q  +L D    
Sbjct: 6333 LSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSS-QSGGAKRQSIHLEQ--KLYDGVSA 6389

Query: 1955 LRKWLTNQEEK-WKGMEEPGEKTE--LFCQ-ALARKREQFESVAQLNNSLKEYGFTE--E 2008
               WL + EE+ +       E+TE  LF Q  LA+  ++       N +L    F E  +
Sbjct: 6390 TSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD 6449

Query: 2009 EEIIMEAT--CLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
               ++E T  CL+ R   L   +++   + K    +  +F +    +   + + K  ++ 
Sbjct: 6450 NRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQ 6509

Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE--SSEAPLVQKTLTDISNQWD 2124
              ++  + P+ E+I+ I++      E DA I  + ++ +    E P +Q+ L+ + + +D
Sbjct: 6510 KLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE-LSKLQDMYD 6568

Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG-----FALQHGLQEKK 2179
              + +  +  S   + L    +Y ++ +DL   L+E  +++ AG      + +  +Q+  
Sbjct: 6569 ELMMIIGSRRSGLNQNLTLKSQYERALQDL-ADLLETGQEKMAGDQKIIVSSKEEIQQLL 6627

Query: 2180 AQLKIYKKFLKKAQDLTSLL----------KELKSQGNYLLECTKNPSFSEEPWLEIKHL 2229
             + K Y + L+    LT  L          KE +     + + +     + +  +E++++
Sbjct: 6628 DKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYI 6687

Query: 2230 HESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKL 2289
             E+    L +  Q L    R+ +  +  +  +    +N         D+ +D+I + + L
Sbjct: 6688 LET-WSHLDEDQQELS---RQLEVVESSIPSVGLVEEN--------EDRLIDRITLYQHL 6735

Query: 2290 Q-KLQELENRL--SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRL 2346
            +  L E + +L   L DG    I      ++   + +G+  + +  K      K+L    
Sbjct: 6736 KSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK----MSKELHR-- 6789

Query: 2347 ASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEIN 2406
                      L +ILK     + +    +   +  A   ++  TQ+S  V    ++ E+ 
Sbjct: 6790 ----------LETILKHWTRYQSESADLIHWLQ-SAKDRLEFWTQQSVTV---PQELEMV 6835

Query: 2407 KDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLEL---DTMLRNEQLEEIEKLYT 2463
            +D  +   +     ++AQ S+K++     V    NQ L L   DT     +L  I+  +T
Sbjct: 6836 RDH-LNAFLEFSKEVDAQSSLKSS-----VLSTGNQLLRLKKVDTATLRSELSRIDSQWT 6889

Query: 2464 QLEAKKAAIK---------PLEQTECLNKTETGALVLHN------------IGYSAQH-- 2500
             L     A++          L     +++  +   ++ N            IGY A H  
Sbjct: 6890 DLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEY 6949

Query: 2501 -----------------LDNLLQALITL-KKNKESQYCVLRDFQEYLAAVESS---MKAL 2539
                             +D + Q+++ +  ++ ES+     DF E L A+  S   ++ L
Sbjct: 6950 LQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 7009

Query: 2540 LTDKESLKVGPLDSVT-YLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES 2598
            +T+K  L  G L+S + Y + ++      E ++  L       +  S      D + LE 
Sbjct: 7010 VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLED 7069

Query: 2599 QIKQLEHGWEQVEQQ----IQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLK 2654
             IK  E   E++EQ     IQ K  ++ V     +TL  ++  T  +L      L++ LK
Sbjct: 7070 LIKAKEKEVEKIEQNGLALIQNK--KEDVSSIVMSTL-RELGQTWANLDHMVGQLKILLK 7126

Query: 2655 SPEERAGNQSMI--ALTTDLQATKHG---FSVLKGQAELQMKRIWGEKEKKNLEDGINNL 2709
            S  ++  +  +    + + L   ++    F +L G  E    ++       NL++  ++L
Sbjct: 7127 SVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV------DNLQNLQDDL 7180

Query: 2710 KKQWETLEPLHLEAENQIKKC------DIRNKMKETILWAKNLLGE----LNPSIPLL-- 2757
            +KQ  +L+         +K+C       + N +KE  +   NLL E    L  S  LL  
Sbjct: 7181 EKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL 7240

Query: 2758 -----------------PDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYE 2800
                              +D  +++ K     D        V +  ++  D +  L T +
Sbjct: 7241 WQRYKDYSKQCASTVQQQEDRTNELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVK 7297

Query: 2801 GS--DLNNTLEDLRNQYQMLVLKSTQRSQ--------QLEFKL-EERSNFFAIIRKFQLM 2849
             S   L+   E L+ Q       + Q  Q         LE  L +++++  A +  ++  
Sbjct: 7298 DSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETF 7357

Query: 2850 VQESETLIIPRVET-AATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELN-V 2907
             +  E L    VE     + +   H   L   Q+ ++E+  G       +    + LN +
Sbjct: 7358 AKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL-KGQMLKFSSMAPDLDRLNEL 7416

Query: 2908 FERLFLED----QLKNLK-----IRTNRIQRFIQNTCNEVEHK--IKFCRQFHE-KTSAL 2955
              RL L D    +++NL      I +   +RF +     ++H+  ++ C  + E      
Sbjct: 7417 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTE 7476

Query: 2956 QEEADSIQRN--ELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWD 3013
            Q+ A  I  N   LL  Q  ++  + E+++ +  L +I     ++L+  +V D    N  
Sbjct: 7477 QKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7536

Query: 3014 FSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVV 3069
             + L      V  + ++    ++ +I+Q   + E   K +  L ++  + +       + 
Sbjct: 7537 LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP 7596

Query: 3070 LKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEE 3129
            L+   +  +  +   ++   R + +  L  E  K+L  +    DS  E   LQ +L AE 
Sbjct: 7597 LQQARTLFDEVQFKEKVF-LRQQGSYILTVEAGKQLLLSA---DSGAE-AALQAEL-AEI 7650

Query: 3130 NDKLYKVLQNMVLELSPKEL-----DEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKH 3184
             +K      +M LE   K+L     D + C+  +  SL  L   K +L Q L  + E  H
Sbjct: 7651 QEKWKSA--SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELH 7708

Query: 3185 IQNEKDNCEAFQEQV--W----AEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQM 3238
               E+  C+  +  V  W     ++  +K   +     ++ S     VE   R++E+L  
Sbjct: 7709 A--EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7766

Query: 3239 QLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEA-------IIIPYRVDVGNPEE 3291
            QL+    LR   + +       + E      E +T +E+       I+I   ++    + 
Sbjct: 7767 QLS----LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDY 7822

Query: 3292 SLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE 3351
              E+ + ++ +++     +Q + E+L   S      +++Y L ++  +   + +   A+ 
Sbjct: 7823 QEEIAIAQENKIQ-----LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 7877

Query: 3352 TEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKAL----- 3406
             + +  L   +   K    + T L+ +E+ L + +     +  E   +L + + L     
Sbjct: 7878 KKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 7937

Query: 3407 --------VSNL----------ISTKEELMKLRQILRLLRLRCTENDGICLLKI-----V 3443
                    V NL           +T  E   ++Q  R L  R      IC + +     +
Sbjct: 7938 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWR---NICAMSMERRLKI 7994

Query: 3444 SALWEKWLSLLEAAKEWEMWCEELKQEWKFVS----------EEIEREAIILDNLQEELP 3493
               W  W   L+    +E W +  ++   F S          EE+++       + E L 
Sbjct: 7995 EETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLT 8054

Query: 3494 EIS-------KTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG 3546
            ++        +      T+    L   + +  +  +  Q  +T +L+R++      E   
Sbjct: 8055 QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE--- 8111

Query: 3547 AVETVPAFQEITSMKERCNKLLQKVQKNKEL-VQTEIQERHSFTKEIIALKNFFQQTTTS 3605
              E   A   I       +  L  ++   E  VQ +I++  +F +EI    N  +Q    
Sbjct: 8112 --EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 8169

Query: 3606 FQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
             + +  +  P  +   EE    L++     + +  ++   + ++  +   + E  + +  
Sbjct: 8170 GEQLIEKSEPLDAAIIEEELDELRR---YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 8226

Query: 3666 KALEDI--------DEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQ 3717
              LED          ++ ++ +L   PS               N+   L Q  ++    +
Sbjct: 8227 LELEDSAALSDLHWHDRSADSLLSPQPS--------------SNLSLSLAQPLRSERSGR 8272

Query: 3718 EIQKKMWDELDLWHSKLNELDSEVQDIVEQD-PGQAQEWMDNLMIPFQQYQQVSQRAECR 3776
            +    + D + L      +L  +++  + +  P + +E  D+     +    +S      
Sbjct: 8273 DTPASV-DSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSAL 8331

Query: 3777 TSQLNKATVKMEEYSDLLKSTEAWIE---------NTSH-----LLAN-PADYDSLRTLS 3821
             SQ+ +    +++    ++ TE  I          +TS+     LL    +  DS++ L 
Sbjct: 8332 ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 8391

Query: 3822 HHASTVQMALEDSEQKHNLLHSI--------FMDLEDLSIIFETDELTQSIQELS---NQ 3870
            H     + +L      H+              +  + LS      +  Q  Q+ +   N 
Sbjct: 8392 HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNS 8451

Query: 3871 VTALQQKIMESLPQIQR--MADDVVAIESEV---KSMEKRVSKIKTILLSKEIFDFSPE- 3924
            + A      E L Q+QR  ++ D+  IE ++   K ++K V   K I+LS  +   SPE 
Sbjct: 8452 IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL--CSPEF 8509

Query: 3925 --EHLKHGEVILENIRPMKKTIAEIVSYQVELR-LPQTGMKPLPVFQRTNQLLQDIKLLE 3981
                 K    + + +  M      + S   E R L Q  +     F   +  L  + +LE
Sbjct: 8510 TQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGL--LLMLE 8567

Query: 3982 NVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER 4041
            N+ + +NE++                   I +N  A+   +H       +L Q++ E+  
Sbjct: 8568 NIDRRKNEIV------------------PIDSNLDAEILQDHHK-----QLMQIKHELLE 8604

Query: 4042 MEKQILSLNQRKEDLLVDLKAT 4063
             + ++ SL      LLV+ + T
Sbjct: 8605 SQLRVASLQDMSCQLLVNAEGT 8626



 Score = 41.2 bits (95), Expect = 0.036
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 305  WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
            W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 8421 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480

Query: 362  DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
               +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 8481 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8536

Query: 422  LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
            L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596

Query: 460  --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
               ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8644

Query: 518  LLEDWHKFIEEKEFLARLDTSFQ 540
            LL++  + I+E E L  + +S Q
Sbjct: 8645 LLKEVSRHIKELEKLLDVSSSQQ 8667



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)

Query: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
            ++ + KE++  +  + ++L   Q ++++L       +H  V+  M  K QIEHL    HR
Sbjct: 316  DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 374

Query: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
              + L L  A+ KQ    +  RL  W +  +K+       + AWL + E  V    +I++
Sbjct: 375  DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 431

Query: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
            +++ E+       ++    +   N    K+   ++ +  + +      D+L  + +R+  
Sbjct: 432  QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491

Query: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
            +       + K   L+  +  +  L    S L++W+ +     S          +++ + 
Sbjct: 492  VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 542

Query: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
                 +  +  EQ+    + +    ++ +    A  +  E +++ +       +WRN+  
Sbjct: 543  YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 599

Query: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
                 R  +EE    W ++ +  +  + WL+ AE+     N SE    +AK++      F
Sbjct: 600  EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 646

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
             R +   + Q   +N     L        +  LKQ +   N RW  L   V     +   
Sbjct: 647  FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 705

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
                ++E+     ++  + TE   +L+     S  +    ++ L   +Q + +   +  +
Sbjct: 706  MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 764

Query: 6303 LIVFGEQLIQKSEP 6316
            +I     LI K  P
Sbjct: 765  IITKTAHLITKESP 778



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)

Query: 6549 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6608
            +K       S+   ++ W+ + E EL  L+ +    D+Q  +++V  +QEI    ++  +
Sbjct: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498

Query: 6609 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6667
             +V +   ++ F Q   + ES  ++++L Q+    E  +       G +   L Q Q F 
Sbjct: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1558

Query: 6668 Q 6668
            +
Sbjct: 1559 E 1559


>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
            [Homo sapiens]
          Length = 3321

 Score = 1954 bits (5061), Expect = 0.0
 Identities = 1200/3329 (36%), Positives = 1858/3329 (55%), Gaps = 124/3329 (3%)

Query: 3645 KYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEK 3704
            K +E++     + E+++ +  +A   ++E   NE+L+    +  + K+        N   
Sbjct: 27   KLTELHQQTIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSAS 84

Query: 3705 MLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ 3764
             L+++    +   E  K++  EL+    KL  L S      E+   Q  E         +
Sbjct: 85   QLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------R 135

Query: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH 3822
            + +++ Q  + R   L  A   M+++   LK  +A +E     L +P          LSH
Sbjct: 136  ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195

Query: 3823 --HASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
              H  +   +L+   Q   L  S     ED   +  +  L  +   L  + + LQ   ++
Sbjct: 196  RQHLLSEMESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQ 252

Query: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENI 3937
                +Q         E E+K +++ +      +  K +   + +E    +   E + + I
Sbjct: 253  QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKI 312

Query: 3938 RPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQ 3997
            +  ++ IA + S    L +       L        L +  + L+            V+  
Sbjct: 313  KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMM 372

Query: 3998 TNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLL 4057
            T      +  L  +      + +   +S   A + P      +    Q ++  Q      
Sbjct: 373  TAGRCHTL--LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--A 428

Query: 4058 VDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSY 4111
              L+     +H      QE  E    P+ T++ G +       +   SE++     ++  
Sbjct: 429  ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALER 488

Query: 4112 LAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKIS 4171
                ++ ++  S K +  + K   SP+   S    +  M E +A      ++Q+   +I+
Sbjct: 489  QQKYQDSLQSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EIN 542

Query: 4172 TSDNSMAQILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVE 4228
               +S+A+ L  +S   +   + +L+   T   E  +T  ++A        +  L  ++E
Sbjct: 543  ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLE 601

Query: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
            + R E  + L   + +  EL+ WL      ++           +E QL+ CQ ML EIE 
Sbjct: 602  EQRQE--QALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQ 659

Query: 4289 KVAFLLETC---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTI 4345
            KV  L E     ++  L     T+ EAE L+ KL+ +K +L ++Q  L +K    Q    
Sbjct: 660  KVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ 719

Query: 4346 LKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFN 4405
             K+ S+ +      P     L    T   Q  RQ   QQQ+ LE +  EQK  ++ +   
Sbjct: 720  EKEESDVDLTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASR 778

Query: 4406 AKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKL 4465
             +++  Q+   +  T+ ++       S E  +     S + Q   KW+ LH E S+K KL
Sbjct: 779  GEEILIQHSAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKL 836

Query: 4466 PLPQLVEPQ----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENM 4521
                L + Q     S    +L  V +Y    PT ++    T+ L+ L Q    + +Q   
Sbjct: 837  LQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGG 895

Query: 4522 TEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYL 4580
             +   I+L++KL++     S  L  VEE L +   L  E+      + E LA ++K++  
Sbjct: 896  AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSE 955

Query: 4581 ALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQN 4640
             +   K    +A    G+N +++ +    L   L    +    R   +K  L    ++QN
Sbjct: 956  EMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQN 1015

Query: 4641 EIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLH 4700
            ++K L+  L  +K  + Q L  +  Q VAEQ++        L+  ++ + +L+  G++L 
Sbjct: 1016 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 1075

Query: 4701 LPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAH 4760
            +    +QE+ KL+D+ D +  ++ +R + L+     +SQ +  LQ + +L++ G+EK+A 
Sbjct: 1076 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 1135

Query: 4761 GHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVK 4820
                   SK  +Q  ++ HK +FQ L + M+L +    KI+   +Q    F  E + +  
Sbjct: 1136 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 1195

Query: 4821 ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
             + +++ + G++L+ +L+ W   DE+   L + LE++ S++PSV LVEE E+RL++RI+ 
Sbjct: 1196 AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL 1255

Query: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
            YQ +K ++     +LYQ L++GK+L+ S+SC +LE Q+ +L E WLS   K+  ELHRL+
Sbjct: 1256 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315

Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
             +LKH   Y  +S  L  WL+S++  L +W +QS+ V Q+L+ +R ++N F EFSKEVD 
Sbjct: 1316 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDA 1375

Query: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
            +SSLK++V+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLP
Sbjct: 1376 QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 1435

Query: 5061 SRKAITEMISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
            SR AI+E++SW++ +E+    DED++ +      +   LQK+K F+++++ KQ  VDFVN
Sbjct: 1436 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 1495

Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
            QS+LQ+S+ DVESKR ++T+FAE LG MN+ W  + G++  KIQ LE LLES +E EN +
Sbjct: 1496 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 1555

Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ES 5238
            Q L  W E QE+RLK   +     SVQ  L DCQD+E+ +  K K +++++Q+ L L ++
Sbjct: 1556 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 1615

Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
                +     S + EL Q  +++   V QLK  ++SVL +W  +   +D++N   +   Y
Sbjct: 1616 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARY 1675

Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEE 5357
             +   + +  SLE ++ QV+NLQ+LQD+ E  E S +K   +  +L   C P V E +  
Sbjct: 1676 SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN 1735

Query: 5358 KCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMS 5417
              +  + RW  + + IA+QLQ +++LLQLW+ Y +   + A+ ++QQE +  +L   + +
Sbjct: 1736 TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN 1795

Query: 5418 GNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-Q 5476
             +   + +   +QD  +L   +   K++      + ++L Q  ++S    +     SL Q
Sbjct: 1796 KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 1855

Query: 5477 RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KE 5529
                LE+ L  +    +  +  ++ F   LE+L+  I+  EE L   D  H  +    +E
Sbjct: 1856 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 1915

Query: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSEL 5589
              +     +L  ++ +PD++ LNE+  +LPL+D  +K +QN+NR W   ++   ER S+L
Sbjct: 1916 RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL 1975

Query: 5590 QGIGL-NEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIA 5648
            Q   L ++ FL  CE W++ L + E+ L V+++ +   LLEQQ+ +++ +AE+   Q I 
Sbjct: 1976 QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 2035

Query: 5649 DSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTS 5708
             S +    +LL+  ++++R EF  + + L+++WQ  ++  +QR+G +D  +RQWQ +   
Sbjct: 2036 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 2095

Query: 5709 VENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL 5768
             E L ++L + S+L  +  G     L Q R+L  E++ KE  F R++ +  LT+EAG++L
Sbjct: 2096 AEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL 2155

Query: 5769 LLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQV 5828
            LL+ D   + ++   ++++Q+ WK    +L E  K+    ++ W++CEK I +   +L+ 
Sbjct: 2156 LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 2215

Query: 5829 LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK 5888
             K +    LP+ HE+LH E+   KELE ++ SWT +L +L  +K  L+ ++  +D+ +L 
Sbjct: 2216 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 2275

Query: 5889 EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI 5948
            E++E L RQWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q  DI I
Sbjct: 2276 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI 2335

Query: 5949 EEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFD 6008
            EEMIEKL+KD  EEI +  ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D
Sbjct: 2336 EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLD 2395

Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQD 6068
            +I +RVKKLKET   +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+
Sbjct: 2396 LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE 2455

Query: 6069 LQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR 6128
            LQRDIE+HS GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR
Sbjct: 2456 LQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR 2515

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHE 6188
            +KIEETWRLWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE
Sbjct: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575

Query: 6189 RLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQRE 6248
             LTQLELINKQYRRLARENRTD+A  LKQMVHEGNQRWDNLQ+RVT++LRRL+HF  QRE
Sbjct: 2576 CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 2635

Query: 6249 EFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGE 6308
            EFE  R+SILVWLTEMDLQLTN+EHFSE D   K++QL  FQQEI+LN NKI+Q+I  GE
Sbjct: 2636 EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 2695

Query: 6309 QLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDME 6368
            QLI+KSEPLDA +IE+EL+EL RYCQEVFGRV R+H++L    P  +DE + S+ E ++E
Sbjct: 2696 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELE 2754

Query: 6369 DPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGD 6424
            D   +    W  R      S +PSS  SL        ERSG +TP SVDSIPLEWDH  D
Sbjct: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 2814

Query: 6425 VGGS----------SSHEEDEEGPYYSALSGKSISDGHS---WHVPDSPSCPEHHYKQME 6471
            +             S  EE ++   +       +S  HS     +       +    Q++
Sbjct: 2815 LSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQ 2874

Query: 6472 GDRNV----PPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE- 6526
               N+     P  P   T YK   G + L        +  + L    ++E+  L G    
Sbjct: 2875 QTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 2931

Query: 6527 -----QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK 6578
                 Q +G  DRWE++QAQ L  +L++KQNL   QQ NSD+++I  WL  TE ELE L+
Sbjct: 2932 HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 2991

Query: 6579 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 6638
              +  +DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q+
Sbjct: 2992 RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 3051

Query: 6639 SLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRA 6698
            +  W+     ++ WRG L+ +LMQCQ FH++S  LLL L +   R+ +    D   D   
Sbjct: 3052 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 3111

Query: 6699 LLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLRE 6758
            L +  ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L +
Sbjct: 3112 LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 3171

Query: 6759 QVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA------ 6804
            +VS      + L+ +  +Q   S   S DE+D SG   P +    P R K  R       
Sbjct: 3172 EVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQ 3231

Query: 6805 ---------VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPS 6855
                      R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P 
Sbjct: 3232 PGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPM 3291

Query: 6856 SEEDYSCTQANNFARSFYPMLRYTNGPPP 6884
            SEEDYSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 3292 SEEDYSCALSNNFARSFHPMLRYTNGPPP 3320



 Score =  218 bits (554), Expect = 2e-55
 Identities = 505/2767 (18%), Positives = 1073/2767 (38%), Gaps = 296/2767 (10%)

Query: 3736 ELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLK 3795
            ELD+ VQ  +EQ+    +     +    + +QQ  ++AE R S+LN+A   +EEY+++L+
Sbjct: 2    ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61

Query: 3796 STEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIF 3855
                WIE    L      ++S   L       Q  LE+S++  + L ++   L+ L+ ++
Sbjct: 62   LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121

Query: 3856 ETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLS 3915
             T++++Q + EL  +   L+Q I   L  +Q  A D+   E+E+K ++  + + +  L S
Sbjct: 122  CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181

Query: 3916 KEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQ 3975
             E+   S +E L H + +L  +  +K  +  +   Q  LR+P+  +  LP+     +L +
Sbjct: 182  PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE 241

Query: 3976 DIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL 4035
            +   L++   +Q  +++  + Q  ++++E+++L+Q++    A   +E   P     + +L
Sbjct: 242  EASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE--GAHREIED-KPVATSNIQEL 298

Query: 4036 QGEIERME----------KQILSLNQRKEDLLVDLK-ATVLNLHQHLKQEQEGVERDRLP 4084
            Q +I R E          +QI SLN + + L +  K AT+L     ++   EG E     
Sbjct: 299  QAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE----- 353

Query: 4085 AVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLW 4144
                 +G +    ++   +    +      +    EES  +  N +  + P+ +S S + 
Sbjct: 354  ---DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVA 410

Query: 4145 KHDKDMEEDRA--SSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTE 4202
              D  + +D A   + S   +Q    KI  S ++  +   P            L P+ T 
Sbjct: 411  NTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEP-----------GLEPSATA 459

Query: 4203 EGTTPPIEADTLDS--SDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQA-NVAV 4259
            +        +TL +  S+ Q  L   +E+ + +  + L +  T++  +EL L ++     
Sbjct: 460  KLGDLQRSWETLKNVISEKQRTLYEALER-QQKYQDSLQSISTKMEAIELKLSESPEPGR 518

Query: 4260 EPETLNADMQQVLEQQLVGCQAMLTEIEHKVA--FLLETCKDQGLGDNGATQHEAEALSL 4317
             PE+  A+ Q ++++ L+  Q  + E++  +A   + E+C +    +  A Q     L+ 
Sbjct: 519  SPESQMAEHQALMDEILM-LQDEINELQSSLAEELVSESC-EADPAEQLALQSTLTVLAE 576

Query: 4318 KLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQ--PVNLSELES--IVTER 4373
            ++ T++      + +L+EK ++        +  E   ++ALQ       EL+S  + T+ 
Sbjct: 577  RMSTIRMKASGKRQLLEEKLND--------QLEEQRQEQALQRYRCEADELDSWLLSTKA 628

Query: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSA-----SN 4428
               +     ++   +E + M+ ++ +  IE     +  +   H+ +   E  A     + 
Sbjct: 629  TLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVAL-SELSVHNENLLLEGKAHTKDEAE 687

Query: 4429 QASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMY 4488
            Q +     +  S+L  Q    DK   +      K         E  V       P V  +
Sbjct: 688  QLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK--------EESDVDLTATQSPGVQEW 739

Query: 4489 NFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVE 4548
                    + +T  TQ     Q  S+LQ Q+         L+++L E    L    S  E
Sbjct: 740  ------LAQARTTWTQ-----QRQSSLQQQK--------ELEQELAEQKSLLRSVASRGE 780

Query: 4549 EMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFD 4608
            E+L         G   +   + L+ E     L +  +K      M    E+ +       
Sbjct: 781  EILIQHSAAETSGDAGE-KPDVLSQE-----LGMEGEKSSAEDQMRMKWESLHQEFSTKQ 834

Query: 4609 N-LQVCLEHTQAAAV-CRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG 4665
              LQ  LE  Q   +  R   L +G+  Y      + K     L+     L Q+  E+S 
Sbjct: 835  KLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL---DGLNQAFEEVSS 891

Query: 4666 QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE---------------VY 4710
            QS   + Q         +   +    L D  ERL +  ALL E               + 
Sbjct: 892  QSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIK 951

Query: 4711 KLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKV 4770
            ++ + +D    +    + E              L G + L+    + + +    Q K ++
Sbjct: 952  EMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL----DSVVNQRCHQMKERL 1007

Query: 4771 ALQAQIENH-KVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQC 4829
                  +N  KV F  L  +  +       IL  L    E   AEQ+  ++  E+  ++ 
Sbjct: 1008 QQILNFQNDLKVLFTSLADNKYI-------ILQKLANVFEQPVAEQIEAIQQAEDGLKEF 1060

Query: 4830 GMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
               +  L ++ ++      S+++  ++       + ++      L + ++   Q +R + 
Sbjct: 1061 DAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 1120

Query: 4890 GKHARLYQTLNE---GKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHL 4946
               A L +T  E   G Q +   S  E++  + K +E +  L    +  +   + L + +
Sbjct: 1121 DL-ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGL----ESHMILTETLFRKI 1175

Query: 4947 LSY--NRDSDQLTKWLESS--------------QHTLNYWK---EQSLNVSQDLDTIRSN 4987
            +S+   +++   T+ +  +              ++ L  W    E    +S+ L+ + S+
Sbjct: 1176 ISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESS 1235

Query: 4988 INNFFEFSKEVDE-----------KSSLKT------AVISIGNQLLHLKETDTATLRASL 5030
            I +     +  D            KSSL         V+  G +L  L     + L + L
Sbjct: 1236 IPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL--LISISCSDLESQL 1293

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS--DEDSVHSP 5088
             Q  + W     ++     +L  +       +    ++I W+ + + +     + SV  P
Sbjct: 1294 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 1353

Query: 5089 SSASQVKHLLQKHKEFRMEMDYKQWIVDFV---NQSLLQLSTCDVESKRYERTEFAEHLG 5145
                 V+  L    EF  E+D +  +   V      LL+L   D  + R E       L 
Sbjct: 1354 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSE-------LS 1406

Query: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVI-- 5203
             ++ QW  +   +    + L QL      S + I  + +W+   E     +QK E  I  
Sbjct: 1407 RIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLME---NVIQKDEDNIKN 1463

Query: 5204 -----SVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPL-------LEDTASRI 5251
                 ++ + L   +  +  +  K   +D + QS L + S  V           +    +
Sbjct: 1464 SIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAM 1523

Query: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK----PVV 5307
            ++ +Q    ++T+  QL   ++ +L+ W  Y     E N+  ++ W+  +  +      +
Sbjct: 1524 NKSWQILQGLVTEKIQL---LEGLLESWSEY-----ENNVQCLKTWFETQEKRLKQQHRI 1575

Query: 5308 LSLETLRCQVENLQSLQDEAESSEGSWEKL-QEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
                +++  +++ Q L+D  ++ E   EK+ Q  +  ++     V+ I+    +   + W
Sbjct: 1576 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTW 1635

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
              ++  +       +S+L  W ++  A  +  + L   EA++       ++G+   E + 
Sbjct: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL--MEARYSLSRFRLLTGS--LEAVQ 1691

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRL-----PQPAESSTHMLLP------GPLHSL 5475
              + +++ LQ D++K + +  +  S+ ++L     P   E+ T+ L          L  +
Sbjct: 1692 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751

Query: 5476 QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFL 5535
                   K LL     ++    Q      + E     ++    N D    +         
Sbjct: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 1811

Query: 5536 NHVLALTAQSPDIEHLNEV--SLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIG 5593
            + +  L      +  L+E+   LK  +   A   +Q+ ++  +     ALE+    Q   
Sbjct: 1812 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQS-DQLSLSQHLCALEQALCKQQTS 1870

Query: 5594 LN---------EKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
            L           K L   E WI   E+I +      ++ L  + E+ +  K         
Sbjct: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELK--------G 1922

Query: 5645 QTIADSYVTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQW 5702
            Q +  S +   L  L+     +    + I     L   W        +R   +   + Q 
Sbjct: 1923 QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH 1982

Query: 5703 QDFTTSVENLFRFLTDTSHLLSA-VKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALT 5761
            Q F    E    FL  T   L+  + G  +  L Q R+  HEL   E+ F R++   ++ 
Sbjct: 1983 QTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA--HELFQAEM-FSRQQILHSII 2039

Query: 5762 LEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKE 5821
            ++ G++LL    +  ++    +++ L + W+ +  +  +      S +  W +  +  ++
Sbjct: 2040 ID-GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 2098

Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE-QSLASWTQNLKELQTMKADLTRHVL 5880
            L+  L  +       L  +   L   + L  E++ +      Q    + T++A     + 
Sbjct: 2099 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 2158

Query: 5881 VED--VMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938
             +      L+ ++  +  +W+   +R+  +K+++   L  W    +   +    L   + 
Sbjct: 2159 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKK 2218

Query: 5939 KVLQTADISIEEM-IEKLQ-KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKL 5996
            K+ Q+     EE+  E+++ K+    +  ++++  QL  + D L    +    + +++++
Sbjct: 2219 KLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERV 2278

Query: 5997 NKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDD 6056
              +  +W+ L   +  R +++ E         +    L  WL ++ES++S+    D+  +
Sbjct: 2279 ELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIE 2336

Query: 6057 QEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRR 6116
            + I+K       L++D ++  A  +        +       ++E++   I+     ++ R
Sbjct: 2337 EMIEK-------LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDR 2389

Query: 6117 WRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE- 6175
            W+++  +   R  K++ET    Q+   + S    WL   E   A P    ++Y S   E 
Sbjct: 2390 WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKP----IVYDSCNSEE 2445

Query: 6176 ----LKRFEAFQRQIHERLTQLELINKQYRRLARE---NRTDT-ASRLKQMVHEGNQRWD 6227
                L   +  QR I +  T +  +      L  +     TD     ++Q     ++RW 
Sbjct: 2446 IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWR 2505

Query: 6228 NL-------QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD 6280
            N+       + ++    R  + F +    FE   +S     +E      +      + A 
Sbjct: 2506 NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIYTVAK 2560

Query: 6281 DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV 6340
            +++++   FQ+++     +++ +     +L +++    A  ++  + E ++    +  RV
Sbjct: 2561 EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 2620

Query: 6341 SRFHRRL 6347
            +   RRL
Sbjct: 2621 TSILRRL 2627



 Score =  120 bits (300), Expect = 6e-26
 Identities = 657/3524 (18%), Positives = 1283/3524 (36%), Gaps = 568/3524 (16%)

Query: 3211 AIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVE 3270
            A++K  E+N      +  K+ +  +L  Q     + R + LN A  +L  Y E +   ++
Sbjct: 6    AVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 65

Query: 3271 SITSLEAIIIPYRVDVGNPEESL-EMPLRKQ---EELESTVAHIQDLTEKLGMISSPEAK 3326
             I   +A ++ +     N    L E  +  Q   EE +   + ++ +TEKL  ++S    
Sbjct: 66   WIE--KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCT 123

Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSM 3386
             ++   + EL  +   +++  K +       L+N +   K  +     L K++  L Q+ 
Sbjct: 124  EKMSQQVAELGRETEELRQMIKIR-------LQNLQDAAKDMKKFEAELKKLQAALEQAQ 176

Query: 3387 SSL--PLSYREAL-ERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIV 3443
            ++L  P   R +L E+L   + L+S + S K ++  ++     LR+       + L    
Sbjct: 177  ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAA 236

Query: 3444 SALWEK----------WLSLLEAA----KEWEMWCEELKQEWKFVSEEIEREAIILDNLQ 3489
              L E+            ++++AA    +++E   + L+Q  +    EIE + +   N+Q
Sbjct: 237  LRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ 296

Query: 3490 EELPEISKTKEAATT----EELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
            E   +IS+ +E A      +E    L+  C+      K   +L  + +     +   +  
Sbjct: 297  ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 356

Query: 3546 GAVETVPAFQEITSMKE--RCNKLLQKVQK-------NKELVQTEIQERHSFTKEIIALK 3596
            G +   P+      M    RC+ LL  V +       N E+         S      A  
Sbjct: 357  GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416

Query: 3597 N----FFQQTTTS-FQNMAFQDHPEKSEQFE------ELQSILKKGKLTFENIMEKLRIK 3645
            N    ++Q  +    Q  A + HP  S   E      E  +  K G L  +   E L+  
Sbjct: 417  NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL--QRSWETLKNV 474

Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
             SE    +   +E Q ++ + +L+ I  K+    LK S S                    
Sbjct: 475  ISEKQRTLYEALERQ-QKYQDSLQSISTKMEAIELKLSES-------------------- 513

Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSE-----VQDIVEQDPGQAQEWMDNLM 3760
              +  ++ E      + + DE+ +   ++NEL S      V +  E DP +       L 
Sbjct: 514  -PEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLT 572

Query: 3761 IPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTL 3820
            +  ++   +  +A        K  +  E+ +D L+  E   E         AD      L
Sbjct: 573  VLAERMSTIRMKAS------GKRQLLEEKLNDQLE--EQRQEQALQRYRCEADELDSWLL 624

Query: 3821 SHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIME 3880
            S  A T+  AL   ++  + + +  MD +++ +  E   +  S   + N+   L+ K   
Sbjct: 625  STKA-TLDTALSPPKEPMD-MEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGK--- 679

Query: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940
                     D+   +  +++ ++  + +++  L  K++      +  +  +V L      
Sbjct: 680  -----AHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDL------ 728

Query: 3941 KKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNE 4000
              T  +    Q  L   +T        Q+    LQ  K LE    EQ  LL+ V  +   
Sbjct: 729  --TATQSPGVQEWLAQARTTWT-----QQRQSSLQQQKELEQELAEQKSLLRSVASR--- 778

Query: 4001 WDEEIENLKQILNNYSAQFSLE-HMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD 4059
              EEI     ++ + +A+ S +    PD   +   ++GE    E Q   +  + E L  +
Sbjct: 779  -GEEI-----LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ---MRMKWESLHQE 829

Query: 4060 LKATVLNLHQHLKQEQEGVERDR----LPAVTSEEGGVAERDASERKLNRRGSMSYLAAV 4115
                   L   L+QEQE V   R    L  V   +G V  +D S          S L  +
Sbjct: 830  FSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS-------AVTSLLDGL 882

Query: 4116 EEEVEESSVKSDNGDEKAEPSPQ------SWSSLWKHDKDMEEDRASSSSGTIVQEAYGK 4169
             +  EE S +S     ++    Q      S +S W  D    E+R   ++  + +E    
Sbjct: 883  NQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD---VEERLFVATALLPEETETC 939

Query: 4170 ISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLD-SSDAQGGLEPRVE 4228
            +        +IL  D    E   E     N   +    P   D  D   D  G L  R+ 
Sbjct: 940  LFNQ-----EILAKDI--KEMSEEMDKNKNLFSQAF--PENGDNRDVIEDTLGCLLGRLS 990

Query: 4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEH 4288
                   +  H  K ++ ++  +     V     T  AD + ++ Q+L          E 
Sbjct: 991  LLDSVVNQRCHQMKERLQQILNFQNDLKVLF---TSLADNKYIILQKLANV------FEQ 1041

Query: 4289 KVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMM----LQEKHSEDQHPT 4344
             VA  +E  +     ++G  + +A  + LK +  K  +E+  M     LQ+ + E     
Sbjct: 1042 PVAEQIEAIQQ---AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMII 1098

Query: 4345 ILKKSS-------EPEHQEALQPV----------NLSELESIVTERPQFSRQKDFQQQQV 4387
              ++S        + +++ ALQ +             + + IV+ + +  +  D  ++  
Sbjct: 1099 GSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYF 1158

Query: 4388 LELKP---MEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSP 4444
              L+    + +  F K I F  +K      Q   +   ++SA  + +       + IL  
Sbjct: 1159 QGLESHMILTETLFRKIISFAVQK----ETQFHTELMAQASAVLKRAHKRGVELEYILET 1214

Query: 4445 QGQNGDKWQYLHHELS-SKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTT 4503
                 +  Q L  +L   +  +P   LVE        ++  +T+Y     +  E +    
Sbjct: 1215 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR---LIDRITLYQHLKSSLNEYQPKLY 1271

Query: 4504 QLED------LRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLY 4557
            Q+ D      +    S+L++Q N   E +++   K       +S+ L  +E +L+    Y
Sbjct: 1272 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNK-------MSKELHRLETILKHWTRY 1324

Query: 4558 REDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHT 4617
            + + S   +H+   A +  + +           +++T P E    L    D+L   LE +
Sbjct: 1325 QSE-SADLIHWLQSAKDRLEFWTQ---------QSVTVPQE----LEMVRDHLNAFLEFS 1370

Query: 4618 Q---AAAVCRSKSLKAGLDYNR-------SYQNEIKRL-----------------YHQL- 4649
            +   A +  +S  L  G    R       + ++E+ R+                  HQL 
Sbjct: 1371 KEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 1430

Query: 4650 ------------IKSKTSLQQSL---------NEISGQSVAEQLQKADAYTVEL------ 4682
                        + S  SL +++         N I  +++ E LQK   + +++      
Sbjct: 1431 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT 1490

Query: 4683 -------------ENAESRVAKLRDEGERLH--------LPYALLQEVYKLEDVLDSMWG 4721
                         ++ ES+ +   D  E+L         L   + +++  LE +L+S W 
Sbjct: 1491 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLES-WS 1549

Query: 4722 MLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKV 4781
                    L + F T+ ++      + +  +IG +      LK  +    L+  I+  + 
Sbjct: 1550 EYENNVQCLKTWFETQEKR------LKQQHRIGDQASVQNALKDCQD---LEDLIKAKEK 1600

Query: 4782 FFQKLVAD-MLLIQAYS---AKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
              +K+  + + LIQ      + I+ S L+     WA        L+    Q  + L+S+L
Sbjct: 1601 EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN-------LDHMVGQLKILLKSVL 1653

Query: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ 4897
             +W      +  +   L     +L    L+  + E +  ++   Q ++ ++  +   L +
Sbjct: 1654 DQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQK 1713

Query: 4898 TLNEGKQLVASVSCPELEGQIAKLEE---QWLSLNKKIDHELHRLQALLKHLLSYNRDSD 4954
              +   QL+     P  E     L+E   +W +L ++I  +L   +ALL+    Y   S 
Sbjct: 1714 FGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSK 1773

Query: 4955 QLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ 5014
            Q    ++  +   N   + + N     D + + I +  +  K +         +  +G Q
Sbjct: 1774 QCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 1833

Query: 5015 LLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMN 5073
            L    +   A+ +++      Q    L   L   Q  L    ++     K++  + +W+ 
Sbjct: 1834 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 1893

Query: 5074 NVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESK 5133
              E     +D  HS S  S ++  +++ K   ++       +D +N+   +L   D E K
Sbjct: 1894 EAEEILQGQDPSHS-SDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK 1952

Query: 5134 RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERL 5193
            R +          +NR W  +      +   L+  L        K +    +L   E++L
Sbjct: 1953 RMQ---------NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL 2003

Query: 5194 KT---------LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLL 5244
                       L++  +    Q  +   Q I + + I  + L         LE G V   
Sbjct: 2004 AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL---------LEQGQVDDR 2054

Query: 5245 EDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYC-MEHS 5303
            ++   ++  L  +   V+ +  Q +  + S +++W+ Y ++ +++    +   Y  M   
Sbjct: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 2114

Query: 5304 KPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAE-IIEEKCQNT 5362
              V + L+  R   + +Q  +      +GS+    E   +L     S AE  ++ +    
Sbjct: 2115 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEI 2174

Query: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA 5422
             ++W   +  + +Q +K   LL+ W+       ++  +L+  + K      +S S  +  
Sbjct: 2175 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKK------LSQSLPDHH 2228

Query: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQR----- 5477
            E L       KEL++ V    +   Q S + D L     +    +L   +  LQR     
Sbjct: 2229 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEEL 2288

Query: 5478 ---AAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHE-----EENLDRLHQQEKE 5529
                +   + +  + NE+     + K+    L  ++  +        EE +++L +  +E
Sbjct: 2289 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE 2348

Query: 5530 NPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQW---IRATATALERC 5586
                   + + L       E L + S +   S++  K L  +N +W   +   A  +++ 
Sbjct: 2349 EIAIAQENKIQLQQMG---ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKL 2404

Query: 5587 SE-LQGIGLNEKFLYCCEKWIQLLE-KIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
             E L  +   +K +     W+  +E ++ + +  D  NS  E+  +    + L+ ++  +
Sbjct: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKH 2463

Query: 5645 QTIADSYVTQSLQLL---DTTEIENRPEFITEFSKLTD-RWQNAVQGVRQRKGDVDGLVR 5700
             T   S +     LL   D    +   + I + ++  D RW+N      +R+  ++   R
Sbjct: 2464 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 2523

Query: 5701 QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRS-LIHELKNKEIH----FQRRR 5755
             WQ          +FL D S     +K  ER + + + S +I+ +  +E+     FQR+ 
Sbjct: 2524 LWQ----------KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV 2573

Query: 5756 TTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQC 5815
              C   LE   K              RR++  +++  D    L +M+ +     + WD  
Sbjct: 2574 HECLTQLELINKQY------------RRLA--RENRTDSACSLKQMVHEGN---QRWDNL 2616

Query: 5816 EKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADL 5875
            +K++  +  RL+    Q E+                +    S+  W   L E+     ++
Sbjct: 2617 QKRVTSILRRLKHFIGQREE---------------FETARDSILVW---LTEMDLQLTNI 2658

Query: 5876 TRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQ 5935
              H    DV    +Q++   ++       +++   +IE  +       EK++ L A +  
Sbjct: 2659 -EHFSECDVQAKIKQLKAFQQE-------ISLNHNKIEQIIAQGEQLIEKSEPLDAAI-- 2708

Query: 5936 MENKVLQTADISIEEMIEKLQKDCME---EINLFSENKLQLKQMGDQLIKASNKSRAAEI 5992
                        IEE +++L++ C E    +  + +  ++L    D+        R  E+
Sbjct: 2709 ------------IEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDE---HDLSDRELEL 2753

Query: 5993 DDKLNKINDRW-QHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVY 6051
            +D     +  W     D + S       + +  Q L    S   T  +     L     Y
Sbjct: 2754 EDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 2813

Query: 6052 DVCDDQEIQKRLA---EQQDLQRDIE-----------QHSAGVESVFNICDVLLHDSDAC 6097
            D+  D E     A   E ++ Q D +            HSA +ES        L DS   
Sbjct: 2814 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSA-LESQIRQLGKALDDSRFQ 2872

Query: 6098 ANETE--CDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDW--LK 6153
              +TE    S   T   LD  ++    +  E    I+   RL  K  ++      +  L 
Sbjct: 2873 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 2932

Query: 6154 SAE-RTAACPNSSEVLYTSA-------KEELKRFEAFQRQIH-------------ERLTQ 6192
            S E +TA   +  E+L   A       K+ L++++ F   ++             E+L +
Sbjct: 2933 STETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQR 2992

Query: 6193 LEL------INKQYRRL----------------------------ARENRTDTASRLKQM 6218
            LEL      I  Q ++L                            ++E+R D   RL QM
Sbjct: 2993 LELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDRLSQM 3051

Query: 6219 VHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHF-SES 6277
                N RWD +   +      L+    Q + F      +L+ L  +D +   +    S  
Sbjct: 3052 ----NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNL 3107

Query: 6278 DAD---DKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQ 6334
            DA+   D  +QL   + E+  +  ++  L     QL+  +E  D +  ++++  +    +
Sbjct: 3108 DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 3167

Query: 6335 EVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPSSPQSLC 6394
             +   VSR  + L         +++ S   +  E            R       +P+  C
Sbjct: 3168 LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKC 3227

Query: 6395 HLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGP 6438
             L  PG   S                H+    G S     E GP
Sbjct: 3228 SLSQPGPSVSS--------------PHSRSTKGGSDSSLSEPGP 3257



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 369/2091 (17%), Positives = 813/2091 (38%), Gaps = 317/2091 (15%)

Query: 1973 GEKTELFCQALARKREQFESVAQLNNSLKEYG--------FTEEEEIIMEATC------- 2017
            G+ TEL  Q + +   +   + Q  + L+EY         + E+ +++   T        
Sbjct: 26   GKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85

Query: 2018 LMDRY---QTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLN--SSEG 2072
            L ++Y   QTLL +  EI+ E + +  + Q         ++  +++ + +  L   + E 
Sbjct: 86   LREQYILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEEL 140

Query: 2073 KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAST 2132
            +  ++ R+Q +++      + +A ++ +    E ++A L    +  +S            
Sbjct: 141  RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---------LKE 191

Query: 2133 YLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGL---QEKKAQLKIYKKFL 2189
             LSH++ LL E E               LK K +A    Q  L   ++  A L +    L
Sbjct: 192  QLSHRQHLLSEMES--------------LKPKVQAVQLCQSALRIPEDVVASLPLCHAAL 237

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD------SVQN 2243
            +  ++ + L      Q N +          E+    ++ L E   ++++D      ++Q 
Sbjct: 238  RLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE 297

Query: 2244 LDGHVREHDS-------YQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELE 2296
            L   +  H+        YQ  +  LN+     + +    +   +    VE   +  ++L+
Sbjct: 298  LQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMK-AKHATMLLTVTEVEGLAEGTEDLD 356

Query: 2297 NRLSLQDGTLKKILALAKS-----VKQNTSSVGQKIIKDDIKSLQ-CKQKD-LENRLASA 2349
              L         ++ +        +   T   G++    +I S   C+    + N  AS 
Sbjct: 357  GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 416

Query: 2350 KQEM--------ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEE 2401
             Q++        E       K   ST    +F  PG E  AT+ + +  +    ++ +  
Sbjct: 417  NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 476

Query: 2402 DWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNE------------LQNQPLELDTM 2449
            + +     A+E     Q SL +  S K    E K++E             ++Q L  + +
Sbjct: 477  EKQRTLYEALERQQKYQDSLQSI-STKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL 535

Query: 2450 LRNEQLEEIEK-LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQAL 2508
            +  +++ E++  L  +L ++     P EQ    +     A  +  I   A     LL+  
Sbjct: 536  MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK 595

Query: 2509 ITLKKNKESQYCVLRDFQEYLAAVES---SMKALLTDKESLKVGPLDSVTYLDKIKKFIA 2565
            +  +  ++ Q   L+ ++     ++S   S KA L    S    P+D    L   +  + 
Sbjct: 596  LNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV 655

Query: 2566 SIEKEKDSLGNLKIKWENL----SNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY--- 2618
             IE++  +L  L +  ENL      H  D + + L  ++++L+    ++++ +  K    
Sbjct: 656  EIEQKVVALSELSVHNENLLLEGKAHTKD-EAEQLAGKLRRLKGSLLELQRALHDKQLNM 714

Query: 2619 ---SQQVVEYDEFTTLMNK-------VQDTEISLQQQQQHLQLRLKSPEERAGNQSM--- 2665
               +Q+  E D   T            Q      QQ+Q  LQ + +  +E A  +S+   
Sbjct: 715  QGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRS 774

Query: 2666 IALTTDLQATKHGFSVLKGQA----ELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            +A   +    +H  +   G A    ++  + +  E EK + ED    ++ +WE+   LH 
Sbjct: 775  VASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED---QMRMKWES---LHQ 828

Query: 2722 EAENQIKKC-DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQ 2780
            E   + K   ++  + +E +L+++     L   +PL   D+ +Q              + 
Sbjct: 829  EFSTKQKLLQNVLEQEQEQVLYSRP--NRLLSGVPLYKGDVPTQ-------------DKS 873

Query: 2781 SVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
            +V SL + +      +++  G     ++   +  Y  +   ST         +EER    
Sbjct: 874  AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDD-----VEER---- 924

Query: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
             +     L+ +E+ET +  +                 E   K+++E+   +  +    + 
Sbjct: 925  -LFVATALLPEETETCLFNQ-----------------EILAKDIKEMSEEMDKNKNLFSQ 966

Query: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH------------KIKFCRQF 2948
             + E N   R  +ED L  L  R + +   +   C++++             K+ F    
Sbjct: 967  AFPE-NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLA 1025

Query: 2949 HEKTSALQEEADSIQR---NELLLNQEVNKGVKE------EIYNLKDRLTAIKCCILQVL 2999
              K   LQ+ A+  ++    ++   Q+   G+KE      E+    D+L   +  + ++ 
Sbjct: 1026 DNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS 1085

Query: 3000 KLKKVFDYIG--LNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE-HGKYQALLSKMR 3056
            KL+ ++D +   +    S L+Q  T   + E+ L++    L+T +E+  G  + ++S   
Sbjct: 1086 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 1145

Query: 3057 AIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNE--NKTFDDS 3114
             I   + K  E           +  L  +I+S  ++K      E++ + +    +     
Sbjct: 1146 EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRG 1205

Query: 3115 FKEKEILQ----IKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV---LNQ 3167
             + + IL+    +  + +E  +  +V+++ +  +   E +E    D++    H+   LN+
Sbjct: 1206 VELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNE 1265

Query: 3168 IKSQLQQ------PLLINLEIKHIQNEKDNC-EAFQEQVWAEMCSIKAVTAIEKQREENS 3220
             + +L Q       LLI++    ++++ +   E +          +  +  I K      
Sbjct: 1266 YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 1325

Query: 3221 SEASDVETKLREFED-LQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAII 3279
            SE++D+   L+  +D L+     S+ +    L    ++L  + E  ++ V++ +SL++ +
Sbjct: 1326 SESADLIHWLQSAKDRLEFWTQQSVTV-PQELEMVRDHLNAFLE-FSKEVDAQSSLKSSV 1383

Query: 3280 IP--------YRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQY 3331
            +          +VD       L     +  +L + +  +Q+   +L M      KL  ++
Sbjct: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQM-----DKLPSRH 1438

Query: 3332 TLQELVSKNSAMKEAFKAQETEAE---------RYLENYK-------CYRKMEEDIYTNL 3375
             + E++S  S M+   +  E   +          YL+ YK       C +   + +  ++
Sbjct: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 1498

Query: 3376 SKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND 3435
             ++ +   +S  S    + E L  + +S  ++  L++ K +L++      LL       +
Sbjct: 1499 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLE-----GLLESWSEYEN 1553

Query: 3436 GICLLKIVSALWEKWL----------SLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
             +  LK      EK L          S+  A K+    C++L+   K   +E+E+     
Sbjct: 1554 NVQCLKTWFETQEKRLKQQHRIGDQASVQNALKD----CQDLEDLIKAKEKEVEKIE--- 1606

Query: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
               Q  L  I   KE  ++  +S L + L Q   N++     L +LL+ +        SS
Sbjct: 1607 ---QNGLALIQNKKEDVSSIVMSTLRE-LGQTWANLDHMVGQLKILLKSVLD----QWSS 1658

Query: 3546 GAVETVPAFQEITSMKERCNKLLQK---VQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
              V    AF +I S        L +   +  + E VQ ++    +   ++   +   Q+ 
Sbjct: 1659 HKV----AFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 1714

Query: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKL--RIKYSEMYTIVPAEIESQ 3660
             +    +  + HP  +   E L + LK+  + + N++E++  +++ S+    +    +  
Sbjct: 1715 GSITNQLLKECHPPVT---ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 1771

Query: 3661 VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
             ++C   ++  +++ +NE+LK+    A  + I +       V   +Q  +  ++    ++
Sbjct: 1772 SKQCASTVQQQEDR-TNELLKA----ATNKDIAD-----DEVATWIQDCNDLLKGLGTVK 1821

Query: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECR-TSQ 3779
              ++   +L      ++D+     ++ D            +   Q+    ++A C+  + 
Sbjct: 1822 DSLFFLHELGEQLKQQVDASAASAIQSD-----------QLSLSQHLCALEQALCKQQTS 1870

Query: 3780 LNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHN 3839
            L    +  E ++  L++ EAWI     +L          + S   ST+Q  +E+ + +  
Sbjct: 1871 LQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP-----SHSSDLSTIQERMEELKGQML 1925

Query: 3840 LLHSIFMDLEDLSIIFE----TDELTQSIQELSNQVTALQQKIMESLPQIQ 3886
               S+  DL+ L+ +       D+  + +Q L+   + +  +  E   ++Q
Sbjct: 1926 KFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976



 Score = 90.9 bits (224), Expect = 4e-17
 Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)

Query: 713  NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
            NQN+    ++E+  ++      TGQ K+A D + ++   E    E + +LD+        
Sbjct: 1106 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 1161

Query: 762  ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
                   +T   + +   + K + F  ELMA++  +L+   +        +++L T    
Sbjct: 1162 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 1218

Query: 815  KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
               + +   Q+ VV+       L + + D  +D     +  +  L  Y  +  Q+L   +
Sbjct: 1219 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 1278

Query: 873  ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
                  S  +L S+  +     +SNT  ++K L  +E +  + T       + +S D+  
Sbjct: 1279 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 1333

Query: 925  KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
              +S    L  + QQ + +  E   + D++   L+  K+++ +  L             +
Sbjct: 1334 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 1393

Query: 968  RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
            ++  T  L  E     S+    L  +    E L +L  ++LPS+ +  EV     L+++ 
Sbjct: 1394 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 1453

Query: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
             QK E  +K +     IH  LQ   G     N   +T            +   +S     
Sbjct: 1454 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 1513

Query: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
            T+ A +         +L+ L  E I        +  LLE +  Y        +NN   + 
Sbjct: 1514 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 1559

Query: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
            + F ++E R          + +Q  L D Q +++   A+ KE E I       + + K+ 
Sbjct: 1560 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 1619

Query: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
                   TL+E   +    L+  +  L+  L+ VL      K +     S L   + ++ 
Sbjct: 1620 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 1678

Query: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
             F L+    +A ++   +L+N+QD + KQ     +     N +LKE HP     + N + 
Sbjct: 1679 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738

Query: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
            +   ++  +   +     + KAL       +D+     +     E  T+    +A++  +
Sbjct: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 1798

Query: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
            A +   T      +  L+K      D    + ++  +  ++  D S  + + +  + LS+
Sbjct: 1799 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 1855

Query: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
             H   +++   ++   L+A +       K+++ +++ I +    +  +DP+         
Sbjct: 1856 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 1908

Query: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
             L  + + ++E + +      MA  L    + G    +N ++ +    L  +   + ++ 
Sbjct: 1909 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 1968

Query: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
             E+  ++   L Q+Q F    ++ +  L+Q E+ + + +  +Y   ++L ++    E+ +
Sbjct: 1969 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 2025

Query: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
             E     ++   ++ +  + Q  L + +  +   F  +  ++ ++W  +  + +     +
Sbjct: 2026 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 2082

Query: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
               +  W +   +   + +W  +             + L Q  T  D  + KE++ + +Q
Sbjct: 2083 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 2142

Query: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
             +   +    +   L   S     LQ   + I  K +     L  +          A L 
Sbjct: 2143 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 2196

Query: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
            +D ++ +  I  +   L+      S  +    EE+  + ++ K     LEN +G  T +L
Sbjct: 2197 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 2252

Query: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
            ++L    +++S         + N +  +LQ  + +L +          +  N+W  FS  
Sbjct: 2253 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 2312

Query: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
               L E     E+K S      +E+ ++KL      E    + +KI+     L+ + + L
Sbjct: 2313 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 2367

Query: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
             KA  +   S +   E++L K+         +  AR K+L+++L  + +L  +  +LR W
Sbjct: 2368 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 2424

Query: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
            L + E                                          +E  + I+  +C 
Sbjct: 2425 LAHIE------------------------------------------SELAKPIVYDSCN 2442

Query: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
             +  Q  L +  E++ + +   T   S  +L   ++H            +  +    L+ 
Sbjct: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 2502

Query: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
            R    + I  +  E   +IE   +        L QK L D S    W  +    + + S 
Sbjct: 2503 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 2551

Query: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
                   G  Y  +KE       ELKK +    A Q  + E   QL++  K  ++     
Sbjct: 2552 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 2594

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
              D    LK++  +GN             + W  ++    S+L++L+  +   +      
Sbjct: 2595 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 2641

Query: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
            DS  V +T+++  L N   E  S  D       V+ K+++L+  +  +SL    +++I+A
Sbjct: 2642 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 2692

Query: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
              + + + +  +   II++++  L+                   C     + +R  +K  
Sbjct: 2693 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 2735

Query: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
            +  LP  E    SD +   ++SAA+  L   W + + DS +    S  LSL+  + +++ 
Sbjct: 2736 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 2792

Query: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
               R     + + PLE D             L   LE+  +   P E  E   + +    
Sbjct: 2793 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 2841

Query: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549
            +   +G S  H   L   +  L K  +     ++  +  + +   +   L T  +     
Sbjct: 2842 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 2900

Query: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609
              +  + +D +K+    +++E++SL         ++ H T       E+Q   +   WE 
Sbjct: 2901 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 2947

Query: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651
            ++ Q   K     Q + ++ +F + +N +     DTE  L+Q Q+           LQ+ 
Sbjct: 2948 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007

Query: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711
            +LK  ++   ++  I L+ +L + +        QA+         KE ++L+D ++ +  
Sbjct: 3008 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 3053

Query: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763
            +W+     LE      ++ + +C   ++M    +L  +N+    N  +P+   L  +IL 
Sbjct: 3054 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 3113

Query: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818
               K   ++ H+ +L  Q  V SL +        L   EG+D     E +    N+ ++L
Sbjct: 3114 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 3169

Query: 2819 VLKSTQRSQQLEFKLEERSN 2838
            + + ++  ++LE  L+  S+
Sbjct: 3170 LKEVSRHIKELEKLLDVSSS 3189



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 363/1901 (19%), Positives = 732/1901 (38%), Gaps = 302/1901 (15%)

Query: 852  ESQKELESYMMRAQQLLGQRESPGE-LISKHKEALIISNTKSLAKYLKAVEELKNNVTED 910
            + QKELE  +   + LL    S GE ++ +H  A    +       L   +EL     E 
Sbjct: 756  QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLS--QELG---MEG 810

Query: 911  IKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEK----------GKLSDNILKLEKQI 960
             K S E++ R    KWESLH E S   + L+  +E+           +L   +   +  +
Sbjct: 811  EKSSAEDQMR---MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV 867

Query: 961  NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK 1020
              + K        GL +  E   S+ G   + + H+E  ++L + + +  +       L 
Sbjct: 868  PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLE--QKLYDGVSATST------WLD 919

Query: 1021 DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE 1080
            D E+++        E   T        +K+   ++   ++  +  S+A     DN+    
Sbjct: 920  DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR---- 975

Query: 1081 KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLER------YDTYRDILEHHLQNNK 1134
              +E T+   L  +       S+++   +   + + ER      +     +L   L +NK
Sbjct: 976  DVIEDTLGCLLGRL-------SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNK 1028

Query: 1135 FRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFE--IISLKLENHVNDIKKPFV 1192
            + I    ++  +      Q     ++ I+   D   KEF+  II LK       +++P  
Sbjct: 1029 YIILQKLANVFE------QPVAEQIEAIQQAEDG-LKEFDAGIIELKRRGDKLQVEQP-S 1080

Query: 1193 IKERDTLKERERELQMTLNTRMESLETALRLVLPVEK-----ASLLLCGSD--------- 1238
            ++E   L++   EL M + +R   L   L L    E+     A LL  G +         
Sbjct: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140

Query: 1239 ----------LPLHKMAIQGF--HLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVL 1286
                      L  HK   QG   H+I  + +++ +  I  ++ K+ +    L    + VL
Sbjct: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKI--ISFAVQKETQFHTELMAQASAVL 1198

Query: 1287 KELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLS 1346
            K  H       + + L+Y    E  +H  +  ++  + LE   +S+ +  L  E   D  
Sbjct: 1199 KRAH------KRGVELEY--ILETWSHLDEDQQELSRQLEVVESSIPSVGL-VEENEDRL 1249

Query: 1347 ASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAF 1406
                 + Q    ++   + +++ + D  K L     ++ +S  D E   +   E  L   
Sbjct: 1250 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRL-----LISISCSDLESQLNQLGECWLSNT 1304

Query: 1407 SIKLSETHGY-GVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVP---- 1461
            +    E H    + + +T           ++ +L+  +Q  + ++     +  TVP    
Sbjct: 1305 NKMSKELHRLETILKHWTRYQS-------ESADLIHWLQSAKDRLEFWTQQSVTVPQELE 1357

Query: 1462 AVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKA 1521
             V+    + +   K +D     K  +    N L   K     T+  +       W     
Sbjct: 1358 MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQW----- 1412

Query: 1522 LVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGK--ENLKKRIAEIEI 1579
              T+ L     V E L Q Q  K      I +  S ISL  + + K  +N+K  I     
Sbjct: 1413 --TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG---- 1466

Query: 1580 VKEEFNEHLEVVD--KINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDY 1637
              +  +E+L+     KI+  CK L          +    + E+          ++KT D+
Sbjct: 1467 -YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK--------RSDKT-DF 1516

Query: 1638 YENLGRALALW--------DKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVH 1689
             E LG     W        +K+  L+ +++ W+E       L    E   +RLK++ ++ 
Sbjct: 1517 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 1576

Query: 1690 EQKTSEFS-RRVAEIQFLLQSSEIPLELQVMESS----ILNKMEHVQKCLTGESNCHALS 1744
            +Q + + + +   +++ L+++ E   E++ +E +    I NK E V            + 
Sbjct: 1577 DQASVQNALKDCQDLEDLIKAKE--KEVEKIEQNGLALIQNKKEDVSS---------IVM 1625

Query: 1745 GSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQI 1804
             +  EL +        +G  + LLK++    S       ++I   +++ ++S+    ++ 
Sbjct: 1626 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSH-KVAFDKINSYLMEARYSL----SRF 1680

Query: 1805 GCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFES 1864
              LT  L  ++ Q +++ +        LQD   K    Q ++   + S     LKEC   
Sbjct: 1681 RLLTGSLEAVQVQVDNLQN--------LQDDLEK----QERSLQKFGSITNQLLKECHPP 1728

Query: 1865 -----SETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVG 1919
                 + T K V  +   L + +  + ++SK     ++L+  +++  K + K+  S +  
Sbjct: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSK-----ALLQLWQRY--KDYSKQCASTV-- 1779

Query: 1920 QEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
            Q+ E    E +  A  K++ D   ++     D  +L K L   ++    + E GE+ +  
Sbjct: 1780 QQQEDRTNELLKAATNKDIAD--DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ 1837

Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMD---RYQTLLRQLSEIE--- 2033
              A A    Q + +     SL ++    E+ +  + T L      Y+T  + L  +E   
Sbjct: 1838 VDASAASAIQSDQL-----SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 1892

Query: 2034 -EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPE 2092
             E +++L  +D S +     +   ++E+K  ++  +S      +   + ++ E+    P 
Sbjct: 1893 VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSS------MAPDLDRLNELGYRLPL 1946

Query: 2093 GDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
             D  I                K + +++  W       +   S  +  LL+ + +L+  E
Sbjct: 1947 NDKEI----------------KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990

Query: 2153 DLRLMLIELKKK--QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLL---KELKSQGN 2207
                 L++ ++K   E     QH L++++A      +   + Q L S++   + L  QG 
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG- 2049

Query: 2208 YLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDN 2267
               +      F+ +  L + +  + ++++ Q     +D  +R+   Y+     L   L  
Sbjct: 2050 ---QVDDRDEFNLKLTL-LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE 2105

Query: 2268 FSKEFVS-FSDKPV---------DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVK 2317
             S   +S     P+         D++  +EK+   Q+    L+++ G  K++L  A S  
Sbjct: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAG--KQLLLSADSGA 2163

Query: 2318 QNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI---LKSKRSTEKKGKFT 2374
            +         I++  KS   + ++ + +LA   ++ E C   I   L+  R+ +KK   +
Sbjct: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223

Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
            LP   ++  ++     +   AV    +D  + + S ++  +S  +S +    +       
Sbjct: 2224 LPDHHEELHAEQMRCKELENAVGSWTDD--LTQLSLLKDTLSAYISADDISIL-----NE 2276

Query: 2435 KVNELQNQPLEL--DTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLH 2492
            +V  LQ Q  EL     LR +Q+ E    +     K       E  E L + E+      
Sbjct: 2277 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK-----ELCEWLTQMESKV---- 2327

Query: 2493 NIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLD 2552
                 +Q+ D L++ +I   K         +D+QE +A  + +   L    E L     +
Sbjct: 2328 -----SQNGDILIEEMIEKLK---------KDYQEEIAIAQENKIQLQQMGERLAKASHE 2373

Query: 2553 SVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLES--QIKQLEHG---- 2606
            S           + IE +   LG +  +W++L + +    KKL E+   ++QL+      
Sbjct: 2374 SKA---------SEIEYK---LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 2421

Query: 2607 --W-EQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQ 2644
              W   +E ++ K         +E    +N+ Q+ +  +++
Sbjct: 2422 RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 2462



 Score = 73.9 bits (180), Expect = 5e-12
 Identities = 322/1774 (18%), Positives = 692/1774 (39%), Gaps = 283/1774 (15%)

Query: 1400 ENLLDAFSIKLSETHGYGVQEEFTEENKLLEACI--------FKNNELLK-NIQDVQSQI 1450
            EN++      +  + GY    E+ ++ K  +  I        F N  +L+ + QDV+S+ 
Sbjct: 1451 ENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKR 1510

Query: 1451 S-------KIGLKDPTVPAVKHRKKSLIRL-DKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
            S       ++G  + +   ++      I+L + +L+ + E + ++Q     L  + + +E
Sbjct: 1511 SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQ----CLKTWFETQE 1566

Query: 1503 KTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLK----QYQNFKSILTTLIQ-KEESV 1557
            K + QQ +         +A V   L+ C  + +L+K    + +  +     LIQ K+E V
Sbjct: 1567 KRLKQQHRI------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620

Query: 1558 ISLQASYMGK-----ENLKKRIAEIEI----VKEEFNEHLEVVDKINQVCKNLQFYLNKM 1608
             S+  S + +      NL   + +++I    V ++++ H    DKIN      ++ L++ 
Sbjct: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680

Query: 1609 KTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFN-LKNVIDEWTEKALQ 1667
            +        +   + VD   ++ +  E    +L +  ++ ++L       + E     L+
Sbjct: 1681 RLLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 1738

Query: 1668 KMEL--HQLTEEDRERLKEELQVHE--QKTSEFSRRVAEIQFLLQSSEIPLELQVMESSI 1723
            ++ +  + L EE  E+L+    + +  Q+  ++S++ A    + Q  +   EL     + 
Sbjct: 1739 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST--VQQQEDRTNELL---KAA 1793

Query: 1724 LNKMEHVQKCLTGESNCHALSGSTAELREDL-------DQAKTQIGMTESLLKALSPSDS 1776
             NK     +  T   +C+ L      +++ L       +Q K Q+  + +   +   SD 
Sbjct: 1794 TNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA---SAIQSDQ 1850

Query: 1777 LEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHF 1836
            L +   L  ++Q + +Q+ S+     Q G L  E     K  E++       + +LQ   
Sbjct: 1851 LSLSQHLCALEQALCKQQTSL-----QAGVLDYET--FAKSLEALEAWIVEAEEILQGQD 1903

Query: 1837 SKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDF-LTLEGRNSKIKQVD 1895
                +D         S I+  ++E         S+   L +L++    L   + +IK++ 
Sbjct: 1904 PSHSSD--------LSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQ 1955

Query: 1896 SVLKH--VKKHLPKAHVKELISWLVGQEFELEK----MESICQARAK---ELEDSLQQLL 1946
            ++ +H  +          +L S+L+  +  LEK    ME + Q   K   E+  + Q LL
Sbjct: 1956 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 2015

Query: 1947 RLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFT 2006
              Q  H                        ELF   +  +++   S+      L E G  
Sbjct: 2016 EQQRAH------------------------ELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051

Query: 2007 EE-EEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLM 2065
            ++ +E  ++ T L +++Q ++R+  +          + Q + ++A  +  W+ E+    M
Sbjct: 2052 DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPM 2111

Query: 2066 VLNSSEGKMPLE--------ERIQKIKEIILLKPEGDARI-----ETIMKQAESSEAPLV 2112
               S  G +P+         + +Q  KE + L+ +G   +     + ++  A+S     +
Sbjct: 2112 ---SGLGSVPIPLQQARTLFDEVQ-FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAAL 2167

Query: 2113 QKTLTDISNQWDNTLHLASTYLSHQEK----LLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
            Q  L +I  +W +    AS  L  Q+K    LL + EK  +   D    L   KKK    
Sbjct: 2168 QAELAEIQEKWKS----ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223

Query: 2169 FALQHG-LQEKKAQLKIYKKFLKK-AQDLT--SLLKELKS---QGNYLLECTKNPSFSEE 2221
                H  L  ++ + K  +  +     DLT  SLLK+  S     + +    +     + 
Sbjct: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283

Query: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL----DNFSKEFVSFSD 2277
             W E+ H      QQ+ + +        ++      +T + + +    D   +E +    
Sbjct: 2284 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 2343

Query: 2278 KPVDQ---IAVEEKLQ---------------KLQELENRLSLQDGTLKKILAL----AKS 2315
            K   +   IA E K+Q               K  E+E +L   +   + +L L     K 
Sbjct: 2344 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 2403

Query: 2316 VKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA-------KQEMECCLNSILKSKRSTE 2368
            +K+   +V Q  +  ++ SL+     +E+ LA          +E++  LN   + +R  E
Sbjct: 2404 LKETLVAVQQ--LDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 2461

Query: 2369 KKG----------KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQ 2418
            K            +  L   +  AT    +S Q+  A   L+  W     +   M+M ++
Sbjct: 2462 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQ--ATRNLDRRWR----NICAMSMERR 2515

Query: 2419 LSLNAQ--------ESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKL--------- 2461
            L +           +     ED  K +E          ++     EE++K          
Sbjct: 2516 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 2575

Query: 2462 -YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520
              TQLE      + L +    N+T++   +   +    Q  DNL + + ++ +  +    
Sbjct: 2576 CLTQLELINKQYRRLARE---NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 2632

Query: 2521 VLRDFQ---EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
               +F+   + +    + M   LT+ E       D    + ++K F   I    + +  +
Sbjct: 2633 QREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKAFQQEISLNHNKIEQI 2690

Query: 2578 KIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY---------------SQQV 2622
              + E L      +D  ++E ++ +L    ++V  ++++ +               S + 
Sbjct: 2691 IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRE 2750

Query: 2623 VEYDEFTTLMN-----KVQDTEISLQQQQQHLQLRLKSP--EERAGNQSMIALTTDLQAT 2675
            +E ++   L +     +  D+ +S  Q   +L L L  P   ER+G  +  ++ +     
Sbjct: 2751 LELEDSAALSDLHWHDRSADSLLS-PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEW 2809

Query: 2676 KHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKC----- 2730
             H +  L    E  M R    ++++  +D    L+     L   H   E+QI++      
Sbjct: 2810 DHDYD-LSRDLESAMSRALPSEDEEGQDDKDFYLRGA-VGLSGDHSALESQIRQLGKALD 2867

Query: 2731 DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIR---KCKVTHDGILARQQSVESLAE 2787
            D R ++++T    +N++    P+ P L       ++   +C  + D +    + +E   +
Sbjct: 2868 DSRFQIQQT----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV----KRLEHKLK 2919

Query: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
            E ++ +P       ++       + +++++L  ++  +  +++  L++   F + +    
Sbjct: 2920 EEEESLPGFVNLHSTETQTA--GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977

Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI------ 2901
              + ++E  +           EL     T+E   K+L+E+   +      + +I      
Sbjct: 2978 AWLGDTEEEL-----EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 3032

Query: 2902 YEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADS 2961
            + + +  E   L+D+L  +  R +R+   ++     ++  +  C+ FHE +  L    ++
Sbjct: 3033 FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 3092

Query: 2962 IQR--NELL-----LNQEVNKGVKEEIYNLKDRL 2988
            I R  NE++     L+ E+ +   +++  +K  L
Sbjct: 3093 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 3126



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 505/2870 (17%), Positives = 1040/2870 (36%), Gaps = 420/2870 (14%)

Query: 1286 LKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDL 1345
            L ELH   +   +N + K       +N      E+  + LE  L  +  AK+ A      
Sbjct: 28   LTELHQQTIRQAENRLSK-------LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 80

Query: 1346 SASDT---QVAQENTLTVKNKE--GEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCE 1400
            +++     Q     TL  ++KE   E+  M +K ++L        MS + AE G +T  E
Sbjct: 81   NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET--E 138

Query: 1401 NLLDAFSIKLSETHGYGVQ-EEFTEENKLLEACIFKNNELL-----------KNIQDVQS 1448
             L     I+L          ++F  E K L+A + +    L           + +   Q 
Sbjct: 139  ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 198

Query: 1449 QISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYE--EEKRHLQEMANSLPHFKDGREKTVN 1506
             +S++    P V AV+  + +L   + V+           LQE A+ L H       T  
Sbjct: 199  LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH-------TAI 251

Query: 1507 QQC---QNTVVLWENTK------------------------ALVTECLEQCGRVLELLKQ 1539
            QQC   Q  VV +E  +                        + + E   Q  R  EL ++
Sbjct: 252  QQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 311

Query: 1540 YQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE-----------HL 1588
             + ++  + +L  K + +++++A +     +   + E+E + E   +           H 
Sbjct: 312  IKGYQEQIASLNSKCK-MLTMKAKHA---TMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 367

Query: 1589 EVVDKINQVCKNLQFYLNKMKTFE-------EPPFEKEANIIVDRWLDINEKTEDYYENL 1641
             VV      C  L   + +    E        PP  +  + + +    +N+    YY+ L
Sbjct: 368  SVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIA-YYQAL 426

Query: 1642 GRALALWD--KLFNLKNVIDEWTEKALQKMELHQLTEEDR--ERLKEELQVHEQKTSEFS 1697
                   D  K+    +   E+ E  L+     +L +  R  E LK  +   ++   E  
Sbjct: 427  SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEAL 486

Query: 1698 RRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757
             R  + Q  LQS  I  +++ +E  +    E  +   +  +   AL      L++++++ 
Sbjct: 487  ERQQKYQDSLQS--ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINEL 544

Query: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQ 1817
              Q  + E L+     +D  E          Q+  Q    +L E           + +  
Sbjct: 545  --QSSLAEELVSESCEADPAE----------QLALQSTLTVLAERMSTIRMKASGKRQLL 592

Query: 1818 YESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQK 1877
             E ++D    ++   Q+   +    +    + W  + K  L       +    +E +L  
Sbjct: 593  EEKLNDQLEEQR---QEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD 649

Query: 1878 LSDFLTLEGRNSKIKQVDSVLKHVKKHLP------KAHVKELISWLVGQ----------- 1920
              + L       +I+Q    L  +  H        KAH K+    L G+           
Sbjct: 650  CQNMLV------EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 703

Query: 1921 EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPG-EKTELF 1979
            +  L   +   Q  A+E E+S   L   Q     +++WL      W    +   ++ +  
Sbjct: 704  QRALHDKQLNMQGTAQEKEESDVDLTATQSP--GVQEWLAQARTTWTQQRQSSLQQQKEL 761

Query: 1980 CQALARKREQFESVAQLNNSL---------------------KEYGF-----TEEEEIIM 2013
             Q LA ++    SVA     +                     +E G      + E+++ M
Sbjct: 762  EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM 821

Query: 2014 EATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGK 2073
            +   L   + T  + L  + E++     ++Q      + ++  +   K  +   + S   
Sbjct: 822  KWESLHQEFSTKQKLLQNVLEQE-----QEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 876

Query: 2074 MPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTY 2133
              L+   Q  +E+      G A+ ++I  + +  +      T  D     +  L +A+  
Sbjct: 877  SLLDGLNQAFEEVS--SQSGGAKRQSIHLEQKLYDGVSATSTWLD---DVEERLFVATAL 931

Query: 2134 LSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ 2193
            L  + +  L  ++ L   +D++ M  E+ K +           E      + +  L    
Sbjct: 932  LPEETETCLFNQEILA--KDIKEMSEEMDKNKNL---FSQAFPENGDNRDVIEDTLGCLL 986

Query: 2194 DLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDS 2253
               SLL  + +Q  + ++       + +   ++K L  SL       +Q L     +  +
Sbjct: 987  GRLSLLDSVVNQRCHQMKERLQQILNFQN--DLKVLFTSLADNKYIILQKLANVFEQPVA 1044

Query: 2254 YQV-CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEE----KLQKLQELENRLSL------- 2301
             Q+  +      L  F    +    +  D++ VE+    +L KLQ++ + L +       
Sbjct: 1045 EQIEAIQQAEDGLKEFDAGIIELKRRG-DKLQVEQPSMQELSKLQDMYDELMMIIGSRRS 1103

Query: 2302 ---QDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLN 2358
               Q+ TLK     A     +    GQ+ +  D K +   +++++  L   K+  +   +
Sbjct: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163

Query: 2359 SILKSKRSTEKKGKFTLPGREK-------QATSDVQESTQESAAVEKLEEDWEINKDSAV 2411
             ++ ++    K   F +    +       QA++ ++ + +    +E + E W    +   
Sbjct: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223

Query: 2412 EMAMSKQL---SLNAQESMKNTED------------ERKVNELQNQPLEL----DTMLRN 2452
            E++   ++   S+ +   ++  ED            +  +NE Q +  ++      +L +
Sbjct: 1224 ELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS 1283

Query: 2453 EQLEEIEKLYTQL-----EAKKAAIKPLEQTECLNKTET-----GALVLHNIGYSAQHLD 2502
                ++E    QL            K L + E + K  T      A ++H +  +   L+
Sbjct: 1284 ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE 1343

Query: 2503 NLLQALITLKKNKESQYCVLRDFQEYLAAVE--SSMKA--LLTDKESLKVGPLDSVTYLD 2558
               Q  +T+ +  E     L  F E+   V+  SS+K+  L T  + L++  +D+ T   
Sbjct: 1344 FWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRS 1403

Query: 2559 KIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKY 2618
            ++ +  +   +  D L N+    E L  H   MDK      I ++      +E  IQK  
Sbjct: 1404 ELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKDE 1458

Query: 2619 S--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALTT 2670
               +  + Y      + K +  +I +  +Q  +       L++ S +  +          
Sbjct: 1459 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAE 1518

Query: 2671 DLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI-K 2728
             L A    + +L+G    +++ + G  E     E+ +  LK  +ET E   L+ +++I  
Sbjct: 1519 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIGD 1577

Query: 2729 KCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEE 2788
            +  ++N +K+                             C+   D I A+++ VE + + 
Sbjct: 1578 QASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQN 1608

Query: 2789 VKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQL 2848
                + +      S + +TL +L   +  L     Q    L+  L++ S+      K   
Sbjct: 1609 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 1668

Query: 2849 MVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE---- 2897
             + E+  +L   R+ T + EA       L++    LE  ++ LQ+  S  +  L+E    
Sbjct: 1669 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 1728

Query: 2898 ----LTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHE 2950
                LTN  +E+N+     LE+   QL++ K      QR+   +        K C     
Sbjct: 1729 VTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYS--------KQC----- 1775

Query: 2951 KTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKVF 3005
              S +Q++ D   R   LL    NK + ++     I +  D L  +      +  L ++ 
Sbjct: 1776 -ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 1831

Query: 3006 DYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDLQ 3061
            + +    D S    +Q+      + L    +   KQ  + +     Y+     + A++  
Sbjct: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 1891

Query: 3062 IKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI------IKKLNENKTFDDSF 3115
            I +  E+ L+  D S  S   +   + +R+E+ K    +       + +LNE   +    
Sbjct: 1892 IVEAEEI-LQGQDPSHSS---DLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPL 1946

Query: 3116 KEKEILQIK-------LNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQI 3168
             +KEI +++       L + +  + +  LQ+ +L+        +   +K ET +  L Q 
Sbjct: 1947 NDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQ-------HQTFLEKCETWMEFLVQT 1999

Query: 3169 KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVET 3228
            + +L   +  N +  H+  ++   E FQ ++++    + ++  I+ QR     +  D + 
Sbjct: 2000 EQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSII-IDGQRLLEQGQVDDRDE 2056

Query: 3229 ---KLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVD 3285
               KL    +    +      R  +++       RY+E   +  + +  +  + +     
Sbjct: 2057 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 2116

Query: 3286 VGNPEESL-----EMPLRKQEELESTVAHIQDLTEKLGMISSPE--AKLQLQYTLQELVS 3338
            V  P +       E+  +++  L    ++I  +     ++ S +  A+  LQ  L E+  
Sbjct: 2117 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 2176

Query: 3339 KNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALE 3398
            K    K A    E + ++     K + K E+ I  +L K+ T   +   SLP  + E   
Sbjct: 2177 K---WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233

Query: 3399 RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAK 3458
               + K L + + S  ++L +L  +   L    + +D   L + V  L  +W  L     
Sbjct: 2234 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293

Query: 3459 EWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYG 3518
                   E   EW   SE+ +    + + L +   ++S+  +    E + +L      Y 
Sbjct: 2294 LRRQQIGERLNEWAVFSEKNKE---LCEWLTQMESKVSQNGDILIEEMIEKLKK---DYQ 2347

Query: 3519 ENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELV 3578
            E +   Q     L Q    +      S A E      ++  + +R   LL  +    + +
Sbjct: 2348 EEIAIAQENKIQLQQMGERLAKASHESKASEIE---YKLGKVNDRWQHLLDLIAARVKKL 2404

Query: 3579 QTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
            +  +       K + +L+ +     +        D    S   EE+Q      KL  +  
Sbjct: 2405 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD----SCNSEEIQR-----KLNEQQE 2455

Query: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNG 3698
            +++   K+S         + S +  C   L D D   ++    S     +++    ++  
Sbjct: 2456 LQRDIEKHS-------TGVASVLNLCEVLLHDCDACATDAECDS-----IQQATRNLDRR 2503

Query: 3699 LHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----------------SEVQ 3742
              N+  M  ++   IE+   + +K  D+   +   L   +                 E  
Sbjct: 2504 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 2563

Query: 3743 DIVEQDPGQAQEWMDNLMIPFQQYQQVSQ--RAECRTSQLNKATVKMEEYSDLLKSTEAW 3800
               E    Q  E +  L +  +QY+++++  R +   S         + + +L K   + 
Sbjct: 2564 KKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI 2623

Query: 3801 IENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDEL 3860
            +    H +    ++++ R      S +    E   Q  N+ H       +  +  +  +L
Sbjct: 2624 LRRLKHFIGQREEFETARD-----SILVWLTEMDLQLTNIEH-----FSECDVQAKIKQL 2673

Query: 3861 TQSIQELSNQVTALQQKIMESLPQIQRMAD-DVVAIESEVKSMEKRVSKI 3909
                QE+S     ++Q I +    I++    D   IE E+  + +   ++
Sbjct: 2674 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV 2723



 Score = 67.0 bits (162), Expect = 6e-10
 Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)

Query: 311  EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
            + L+ L+K  E +    + N L + +++  E+  S   V+S  R+L +           W
Sbjct: 1589 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 1635

Query: 371  DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
              LDH +   KI L   L        A+ +    LM+   S S+    + ++  +Q ++ 
Sbjct: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 1695

Query: 429  LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
              ++L D  E     L     +T +   E H P+     N L+E+  R NN+LE+    +
Sbjct: 1696 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 1751

Query: 482  LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
             E       +L L    K  SK     ++     + ELL    +K I + E    + T  
Sbjct: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 1807

Query: 540  QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
            Q C ++ K L                      A     I    + +   +C   + +   
Sbjct: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 1867

Query: 578  KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
            +++LQ  +  + T+ ++L  L A   E                 T +E ++E+  + L  
Sbjct: 1868 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 1927

Query: 621  WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
             ++  +   LNE G  L     ++      K ++ LN+ W  + S+T    +       Q
Sbjct: 1928 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 1981

Query: 679  DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
             Q   +     +    +  V+    ++VE+  NY   ++    HE    E   + ++   
Sbjct: 1982 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 2037

Query: 738  ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
               D ++L+ Q ++                W+       + + ++D    Q      M E
Sbjct: 2038 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 2097

Query: 769  SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
             L+  + + S                   +FDE+  + +  L+     I + E+ + +L 
Sbjct: 2098 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 2157

Query: 810  T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
            +        LQA++ E +EK +   ++L    K L  +  D +   K + +S ++L ++ 
Sbjct: 2158 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 2217

Query: 862  MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
             +  Q L          ++  K  E  + S T  L +     + L   ++ D    L E+
Sbjct: 2218 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 2277

Query: 919  SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
               +  +WE L H+LSL  QQ+        +  EK K L + + ++E ++++   ++   
Sbjct: 2278 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 2337

Query: 971  RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
              + L K++  E   ++E  + QL    E L +   E  + + + ++ ++   ++  ++ 
Sbjct: 2338 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 2396

Query: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
            +   +K   E  + +Q      S     +   E+    P      +SE    K + Q   
Sbjct: 2397 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 2456

Query: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
            ++ +E      +ASVL  L E  + + D  A      SI       D  +R+I    +E 
Sbjct: 2457 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 2514

Query: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
             L+  +      +   D+S  ED  +SS    A  +   VI        K+FE    ++ 
Sbjct: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574

Query: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
              +     I K +    R+   +    L+  +   N R ++L+  +  +L          
Sbjct: 2575 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 2634

Query: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
                  + S+L+  +++ L    I+ F   D     + L+  Q  I+       ++   G
Sbjct: 2635 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 2694

Query: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
              ++++  P D   ++  + + +   + +  RV+R    L                    
Sbjct: 2695 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 2754

Query: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378
               AL D     R+A   LS +P ++LS S  Q  +    + ++    +  +  +  H  
Sbjct: 2755 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 2813

Query: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435
               + L+ +   A   +D   ++  D +   ++ LS  H   ++ +  +  K L+   F+
Sbjct: 2814 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 2872

Query: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491
                      +Q   + I  K PT P +    K  ++L       +D  +  +  L+E  
Sbjct: 2873 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 2922

Query: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549
             SLP F +    +   Q    +  WE    L  + L +  R+ + L+++Q F S L +  
Sbjct: 2923 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977

Query: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
              L   EE +  LQ     +  L   I  IE+  ++  E  + VD    +  ++      
Sbjct: 2978 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 3029

Query: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663
                  P F +            ++++ D  + L +    WD++ +L   ++EW     +
Sbjct: 3030 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 3071

Query: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712
              +Q    H+++       E+ +R K E+      +  +   +  +++ +I+  L  S++
Sbjct: 3072 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 3131

Query: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771
             +  LQ M   +L   E    CL  +   H +      L+  L +    I   E LL   
Sbjct: 3132 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 3187

Query: 1772 SPSDSLEIFTKLEEI 1786
            S    L  ++  +E+
Sbjct: 3188 SSQQDLSSWSSADEL 3202



 Score = 41.2 bits (95), Expect = 0.036
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 305  WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
            W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 2945 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 3004

Query: 362  DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
               +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 3005 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 3060

Query: 422  LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
            L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120

Query: 460  --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
               ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 3168

Query: 518  LLEDWHKFIEEKEFLARLDTSFQ 540
            LL++  + I+E E L  + +S Q
Sbjct: 3169 LLKEVSRHIKELEKLLDVSSSQQ 3191


>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform 4
            [Homo sapiens]
          Length = 556

 Score = 1026 bits (2653), Expect = 0.0
 Identities = 519/556 (93%), Positives = 519/556 (93%), Gaps = 37/556 (6%)

Query: 6367 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 6426
            MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG
Sbjct: 1    MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 60

Query: 6427 GSSSHEEDEEGPYYSALS-----------------------GKSISDGHSWHVPDSPSCP 6463
            GSSSHEEDEEGPYYSALS                       GKSISDGHSWHVPDSPSCP
Sbjct: 61   GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 120

Query: 6464 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 6523
            EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG
Sbjct: 121  EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 180

Query: 6524 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 6583
            ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP
Sbjct: 181  ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 240

Query: 6584 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 6643
            SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE
Sbjct: 241  SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 300

Query: 6644 AAQGAVDSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHV 6689
            AAQGAVDSWRGGLRQSLMQCQ              DFHQLSQNLLLWLASAKNRRQKAHV
Sbjct: 301  AAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHV 360

Query: 6690 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 6749
            TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI
Sbjct: 361  TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 420

Query: 6750 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 6809
            EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE
Sbjct: 421  EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 480

Query: 6810 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 6869
            GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA
Sbjct: 481  GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 540

Query: 6870 RSFYPMLRYTNGPPPT 6885
            RSFYPMLRYTNGPPPT
Sbjct: 541  RSFYPMLRYTNGPPPT 556



 Score = 40.8 bits (94), Expect = 0.047
 Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)

Query: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
            A I ++ +   DRW+ +         K+K+    +QQL+ ++S + TWL + E+EL    
Sbjct: 179  AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 235

Query: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
            +     D QEI+ R+   Q++ +  + + A V SV       L      + E      + 
Sbjct: 236  MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 295

Query: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
              + +  +     WR     S+ +    +   R    F  D+ +       WL SA+   
Sbjct: 296  SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 355

Query: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
                   P +        + EL + E   +++ ER  Q++++ +    L  +   +    
Sbjct: 356  QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 412

Query: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
             ++ VH   ++   L+ +V+  L  L+   N
Sbjct: 413  AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443



 Score = 35.0 bits (79), Expect = 2.6
 Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)

Query: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
            ELH    + ++L   N D   +T WL+ ++  L   K        D+  I   +    E 
Sbjct: 199  ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 256

Query: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
             K  D   +L  +V     + L  +  ++  L++ L Q    W
Sbjct: 257  LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 299


>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform 3
            [Homo sapiens]
          Length = 982

 Score =  935 bits (2416), Expect = 0.0
 Identities = 514/985 (52%), Positives = 650/985 (65%), Gaps = 80/985 (8%)

Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
            MG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET   +QQLDKNMS+LR
Sbjct: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60

Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
            TWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD D
Sbjct: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120

Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
            ACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+
Sbjct: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180

Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRL 6215
            ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A  L
Sbjct: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240

Query: 6216 KQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFS 6275
            KQMVHEGNQRWDNLQ+RVT++LRRL+HF  QREEFE  R+SILVWLTEMDLQLTN+EHFS
Sbjct: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300

Query: 6276 ESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
            E D   K++QL  FQQEI+LN NKI+Q+I  GEQLI+KSEPLDA +IE+EL+EL RYCQE
Sbjct: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360

Query: 6336 VFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQ 6391
            VFGRV R+H++L    P  +DE + S+ E ++ED   +    W  R      S +PSS  
Sbjct: 361  VFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419

Query: 6392 SLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG-------GSSSHEEDEEGPYYSALS 6444
            SL        ERSG +TP SVDSIPLEWDH  D+          +   EDEEG       
Sbjct: 420  SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479

Query: 6445 GKSISDGHSWHVPDSPSC----PEHHYKQMEGD--------------------------- 6473
             +         +P+SP       E+  K   GD                           
Sbjct: 480  LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 539

Query: 6474 --RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE----- 6526
              R+  P  P   T YK   G + L        +  + L    ++E+  L G        
Sbjct: 540  IIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 596

Query: 6527 -QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP 6582
             Q +G  DRWE++QAQ L  +L++KQNL   QQ NSD+++I  WL  TE ELE L+  + 
Sbjct: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656

Query: 6583 PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 6642
             +DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q++  W
Sbjct: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716

Query: 6643 EAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 6702
            +     ++ WRG L+ +LMQCQ FH++S  LLL L +   R+ +    D   D   L + 
Sbjct: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776

Query: 6703 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS- 6761
             ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L ++VS 
Sbjct: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836

Query: 6762 -----QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA---------- 6804
                 + L+ +  +Q   S   S DE+D SG   P +    P R K  R           
Sbjct: 837  HIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPS 896

Query: 6805 -----VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEED 6859
                  R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P SEED
Sbjct: 897  VSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEED 956

Query: 6860 YSCTQANNFARSFYPMLRYTNGPPP 6884
            YSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 957  YSCALSNNFARSFHPMLRYTNGPPP 981



 Score = 80.5 bits (197), Expect = 5e-14
 Identities = 66/361 (18%), Positives = 157/361 (43%), Gaps = 23/361 (6%)

Query: 5765 GEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKS 5824
            GE+L   +       +  ++ ++ D W+ +   +A  +K+ + T+    Q +K +  L++
Sbjct: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61

Query: 5825 RLQVLKAQSEDPL-------PELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR 5877
             L  ++++   P+        E+   L+ ++EL +++E+        L   + +  D   
Sbjct: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121

Query: 5878 HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME 5937
                 +   +++   +L R+W ++C     R+ +IE+    W  F +       WL   E
Sbjct: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181

Query: 5938 NKVLQTADISIEEMIEKLQKDCMEEINLFS----ENKLQLKQMGDQLIKASNKSR---AA 5990
                  A  S   +I  + K+ +++   F     E   QL+ +  Q  + + ++R   A 
Sbjct: 182  R---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238

Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
             +   +++ N RW +L   + S +++LK      ++ +    ++  WL  ++ +L+    
Sbjct: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298

Query: 6051 YDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDS---DACANETECDSIQ 6107
            +  CD   +Q ++ + +  Q++I  +   +E +    + L+  S   DA   E E D ++
Sbjct: 299  FSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355

Query: 6108 Q 6108
            +
Sbjct: 356  R 356



 Score = 61.6 bits (148), Expect = 3e-08
 Identities = 146/799 (18%), Positives = 302/799 (37%), Gaps = 132/799 (16%)

Query: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASY--MGKENLKKR 1573
            W++   L+   +++    L  ++Q     S L T +   ES ++    Y     E ++++
Sbjct: 28   WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRK 87

Query: 1574 IAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR-WLDINE 1632
            + E + ++ +  +H   V  +  +C+ L    +   T  E    ++A   +DR W +I  
Sbjct: 88   LNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 147

Query: 1633 KTEDYYENLGRALALWDKLFNLKNVIDEWTEKA--------------------LQKMELH 1672
             + +    +     LW K  +  +  ++W + +                    L+K E  
Sbjct: 148  MSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAF 207

Query: 1673 Q-------------------LTEEDRE----RLKEELQVHEQKTSEFSRRVAEI------ 1703
            Q                   L  E+R      LK+ +    Q+     +RV  I      
Sbjct: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKH 267

Query: 1704 ------QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757
                  +F      I + L  M+  + N +EH  +C   ++    L     E+  + ++ 
Sbjct: 268  FIGQREEFETARDSILVWLTEMDLQLTN-IEHFSECDV-QAKIKQLKAFQQEISLNHNKI 325

Query: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ-----QKHSMILLENQIGCLTPELS 1812
            +  I   E L++   P D+  I  +L+E+++   +     +++   L+   +     +LS
Sbjct: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385

Query: 1813 ELKKQYE---SVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSET-- 1867
            + + + E   ++SDL    +S        LL+ Q        SN+ ++L +   S  +  
Sbjct: 386  DRELELEDSAALSDLHWHDRSA-----DSLLSPQPS------SNLSLSLAQPLRSERSGR 434

Query: 1868 -------------------KKSVEQKLQKLSDFLTLEGRNSK---IKQVDSVLKHVKKHL 1905
                                + +E  + +       EG++ K   ++    +   +    
Sbjct: 435  DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 494

Query: 1906 PKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEK 1965
            P+A+VK   + +     +   +ES  +   K L+DS  Q+ + ++  R+        +  
Sbjct: 495  PEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554

Query: 1966 WKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEY-----GFTEEEEIIMEATCLMD 2020
            +KG          + + L       +SV +L + LKE      GF        +   ++D
Sbjct: 555  YKG----------YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID 604

Query: 2021 RYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI---KEIKESLMVLNSSEGKMPLE 2077
            R++ L  Q    E   K    + Q FN   + +  W+   +E  E L  L  S     +E
Sbjct: 605  RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664

Query: 2078 ERIQKIKEIILLKPEGDARIETI------MKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
             +I+K+KE+        A I +I        QA+S E+  +Q  L+ ++ +WD    L  
Sbjct: 665  LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLE 724

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-----LQEKKAQLKIYK 2186
             +    +  L++ + + +    L LML  + +++     +        LQ+   QL   K
Sbjct: 725  EWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIK 784

Query: 2187 KFLKKAQDLTSLLKELKSQ 2205
              L ++Q   + L+++  Q
Sbjct: 785  HELLESQLRVASLQDMSCQ 803



 Score = 55.8 bits (133), Expect = 1e-06
 Identities = 128/669 (19%), Positives = 264/669 (39%), Gaps = 77/669 (11%)

Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE-TEERLVERISFYQQIKRNIGG 4890
            KL+  L   ++ D+N +SL   L  + S L    + +    E +  +++  Q+++R+I  
Sbjct: 41   KLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 100

Query: 4891 KHARLYQTLNEGKQLV-------ASVSCPELEGQIAKLEEQW-----LSLNKKIDHELHR 4938
                +   LN  + L+           C  ++     L+ +W     +S+ +++  E   
Sbjct: 101  HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE-ET 159

Query: 4939 LQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEV 4998
             +   K L  Y+R  D    WL+SS+ T  +     +  +      +  +  F  F ++V
Sbjct: 160  WRLWQKFLDDYSRFED----WLKSSERTAAFPSSSGVIYT----VAKEELKKFEAFQRQV 211

Query: 4999 DEKSSLKTAVISIGNQLLHLKETDTA-TLRASLAQFEQKWTMLITQLPDIQEKLHQLQME 5057
             E  +    +     +L     TD+A +L+  + +  Q+W  L  ++  I  +L     +
Sbjct: 212  HECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQ 271

Query: 5058 KLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF 5117
            +     A   ++ W+  ++ Q ++ +        +++K L    K F+ E+       + 
Sbjct: 272  REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL----KAFQQEISLNH---NK 324

Query: 5118 VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE--- 5174
            + Q + Q      +S+  +     E L E+ R    V G + R  + L +L     E   
Sbjct: 325  IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 384

Query: 5175 SENKIQILN-------NWLEAQEERLKTLQKPESVISV---QKLLLDCQDIENQLAIKSK 5224
            S+ ++++ +       +W +   + L + Q P S +S+   Q L  +    +   ++ S 
Sbjct: 385  SDRELELEDSAALSDLHWHDRSADSLLSPQ-PSSNLSLSLAQPLRSERSGRDTPASVDSI 443

Query: 5225 ALD-----ELKQSYLTLESGAVPLLEDTASRIDELFQKRSSV----------------LT 5263
             L+     +L +   +  S A+P  ED   + D+ F  R +V                LT
Sbjct: 444  PLEWDHDYDLSRDLESAMSRALP-SEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502

Query: 5264 QVNQLKTSMQSVLQEWKI--YDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQ 5321
            +     TS      E +I    +  D+      +    +    P    L+T     +   
Sbjct: 503  ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT---SYKGYM 559

Query: 5322 SLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEI--IEEKCQNTHKRWTQVN-QAIADQLQ 5378
             L  E  SS  S ++L+  + + +   P    +   E +      RW  +  QA++ +L+
Sbjct: 560  KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619

Query: 5379 KAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHD 5438
              Q+ LQ W+ +++      A L   E + +QL  + +S +   + +   ++ +KELQ  
Sbjct: 620  MKQN-LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD--IQTIELQIKKLKELQKA 676

Query: 5439 VQKTKEAFL 5447
            V   K   L
Sbjct: 677  VDHRKAIIL 685



 Score = 55.8 bits (133), Expect = 1e-06
 Identities = 56/290 (19%), Positives = 127/290 (43%), Gaps = 9/290 (3%)

Query: 4901 EGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWL 4960
            E + L   V+    E Q A + ++W  L  +   +  R++  L+    +N D + +  WL
Sbjct: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641

Query: 4961 ESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
              ++  L   + Q L +S D+ TI   I    E  K VD + ++  ++     +      
Sbjct: 642  GDTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS 699

Query: 5021 TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080
             ++  L+  L+Q   +W  + + L + +  L    M+     +    ++  + N++ + +
Sbjct: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759

Query: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEF 5140
            +   + S   A     +LQ H +  M++ + + +   +  + LQ  +C +     E T+ 
Sbjct: 760  EIVPIDSNLDA----EILQDHHKQLMQIKH-ELLESQLRVASLQDMSCQL-LVNAEGTDC 813

Query: 5141 AEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
             E   +++   +R+  +L    +H+++ LE + +  +  Q L++W  A E
Sbjct: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKE-LEKLLDVSSSQQDLSSWSSADE 862



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 68/357 (19%), Positives = 146/357 (40%), Gaps = 16/357 (4%)

Query: 5673 EFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERF 5732
            +  K+ DRWQ+ +  +  R   +   +   Q    ++ +L  +L      L+     +  
Sbjct: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79

Query: 5733 SLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE----SVGRRISQLQ 5788
            +  + +  ++E +  +   ++  T  A  L   E LL   D    +    S+ +    L 
Sbjct: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139

Query: 5789 DSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP-LPELHEDLHN- 5846
              W+++    A  +++     ETW   +K + +       LK+       P     ++  
Sbjct: 140  RRWRNI---CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196

Query: 5847 EKELIKELEQSLASWTQNLKELQTMKAD---LTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
             KE +K+ E       + L +L+ +      L R    +    LK+ +   +++W++L  
Sbjct: 197  AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 256

Query: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCM 5960
            RV    + ++  +     F      +  WL +M+     +   ++  ++  I++L K   
Sbjct: 257  RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL-KAFQ 315

Query: 5961 EEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
            +EI+L      Q+   G+QLI+ S    AA I+++L+++    Q +F  +    KKL
Sbjct: 316  QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372



 Score = 48.5 bits (114), Expect = 2e-04
 Identities = 40/189 (21%), Positives = 86/189 (45%), Gaps = 9/189 (4%)

Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR 6013
            KL  +C   I+     + +LK+  + L    N       + +   + DRW+ L     S+
Sbjct: 560  KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST---ETQTAGVIDRWELLQAQALSK 616

Query: 6014 VKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDD-QEIQKRLAEQQDLQRD 6072
              ++K+     QQ + +++++  WL   E EL +    ++  D Q I+ ++ + ++LQ+ 
Sbjct: 617  ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 676

Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE 6132
            ++   A + S+ N+C      +D+     E   +Q     ++ RW  +C++  E R  ++
Sbjct: 677  VDHRKAIILSI-NLCSPEFTQADS----KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQ 731

Query: 6133 ETWRLWQKF 6141
            +     Q F
Sbjct: 732  DALMQCQGF 740



 Score = 46.2 bits (108), Expect = 0.001
 Identities = 78/381 (20%), Positives = 156/381 (40%), Gaps = 35/381 (9%)

Query: 5816 EKKIKEL-----KSRLQVLKAQ----SEDPL-PELHEDLHNEKELIKELEQSLASWTQNL 5865
            E +I++L      SR Q+ + +    S+ P  PEL        +L+ E   S+ S  +  
Sbjct: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 576

Query: 5866 KELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
             +L+  +  L   V +      + Q   +  +WE L  +   ++  ++  L  W  FN  
Sbjct: 577  HKLKEEEESLPGFVNLHST---ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 633

Query: 5926 NKELCAWLVQMENKV--LQTADISIEEMIEKLQKDCMEEINLFSENK----LQLKQMGDQ 5979
               + AWL   E ++  LQ  ++S +    +LQ   ++E+    +++    L +     +
Sbjct: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 693

Query: 5980 LIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA 6039
              +A +K  + ++ D+L+++N RW  +  ++      L++     Q   +    L   L 
Sbjct: 694  FTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 752

Query: 6040 RIESELSKPVVYDVCDDQEI-QKRLAEQQDLQRDIEQHSAGVESVFNI-CDVLLHDSDAC 6097
             I+   ++ V  D   D EI Q    +   ++ ++ +    V S+ ++ C +L++     
Sbjct: 753  NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN----- 807

Query: 6098 ANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER 6157
            A  T+C   ++    +  R + +    + R +K  E      K LD  S  +D L S   
Sbjct: 808  AEGTDCLEAKEKVHVIGNRLK-LLLKEVSRHIKELE------KLLDVSSSQQD-LSSWSS 859

Query: 6158 TAACPNSSEVLYTSAKEELKR 6178
                  S  V  TS +    R
Sbjct: 860  ADELDTSGSVSPTSGRSTPNR 880



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 96/461 (20%), Positives = 167/461 (36%), Gaps = 79/461 (17%)

Query: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLS-HH 3823
            ++Q +      R  +L +  V +++    + S   W+ +    LA P  YDS  +     
Sbjct: 27   RWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQR 86

Query: 3824 ASTVQMALEDSEQKH--------NLLHSIFMDLEDLSIIFETDELTQSIQELSNQ---VT 3872
                Q  L+   +KH        NL   +  D +  +   E D + Q+ + L  +   + 
Sbjct: 87   KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 146

Query: 3873 ALQQ----KIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLK 3928
            A+      KI E+    Q+  DD    E  +KS E+  +   +   S  I+  + EE   
Sbjct: 147  AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS---SGVIYTVAKEE--- 200

Query: 3929 HGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQN 3988
                 L+     ++ + E ++   +L L     + L    RT+      +++    Q  +
Sbjct: 201  -----LKKFEAFQRQVHECLT---QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWD 252

Query: 3989 EL----------LKVVIKQTNEWDEEIENLKQILNNYSAQF-SLEHMSP-DQADKLPQLQ 4036
             L          LK  I Q  E++   +++   L     Q  ++EH S  D   K+ QL 
Sbjct: 253  NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL- 311

Query: 4037 GEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAER 4096
                +  +Q +SLN  K + ++     ++   + L       E D L     E  G  ER
Sbjct: 312  ----KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 367

Query: 4097 DASER-KLNRRGSMSYLAAVEEEVEESSVKSD------NGDEKAEPSPQSWSSL------ 4143
               +  +L        L+  E E+E+S+  SD      + D    P P S  SL      
Sbjct: 368  YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 427

Query: 4144 -------------------WKHDKDMEEDRASSSSGTIVQE 4165
                               W HD D+  D  S+ S  +  E
Sbjct: 428  RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSE 468



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 155/846 (18%), Positives = 325/846 (38%), Gaps = 147/846 (17%)

Query: 4913 ELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972
            E+E ++ K+ ++W  L   I   + +L+  L  +   +++   L  WL    H  +   +
Sbjct: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL---AHIESELAK 72

Query: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLH-----LKETDTATLR 5027
              +  S + + I+  +N   E  +++++ S+   +V+++   LLH       + +  +++
Sbjct: 73   PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 132

Query: 5028 ASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHS 5087
             +    +++W  +     + + K+ +            +    W+       S E +   
Sbjct: 133  QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK------SSERTAAF 186

Query: 5088 PSSASQV----KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEH 5143
            PSS+  +    K  L+K + F+ ++      ++ +N+   +L+       R  RT+ A  
Sbjct: 187  PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACS 239

Query: 5144 LGEM----NRQW----HRVHGMLNRKIQHL-----------EQLLESITESENKIQILNN 5184
            L +M    N++W     RV  +L R+++H            + +L  +TE + ++  + +
Sbjct: 240  LKQMVHEGNQRWDNLQKRVTSIL-RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298

Query: 5185 W----LEAQEERLKTLQ--------KPESVISVQKLLLDCQDIENQLAIKSKALDELKQS 5232
            +    ++A+ ++LK  Q        K E +I+  + L++  +     AI  + LDEL++ 
Sbjct: 299  FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE-PLDAAIIEEELDELRR- 356

Query: 5233 YLTLESGAV----------PLLEDTASRID-ELFQKRSSVLTQVNQLKTSMQSVLQEWKI 5281
            Y     G V          PL +D     D EL  + S+ L+ ++    S  S+L     
Sbjct: 357  YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS---- 412

Query: 5282 YDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQ----------VENLQSLQDEAESSE 5331
              Q    +++   +        +    S++++  +          +E+  S    +E  E
Sbjct: 413  -PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471

Query: 5332 GSWEK---LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWK 5388
            G  +K   L+  +G    + P   E   +  +N  K  +  + A+  Q++      QL K
Sbjct: 472  GQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR------QLGK 525

Query: 5389 AYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL---PPALQDIKELQHDVQKTKEA 5445
            A  ++  +         +K      +  S     ++L     ++  +K L+H +++ +E+
Sbjct: 526  ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 585

Query: 5446 F----------LQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFV 5495
                        Q + V+DR                   L +A  L K L +K N     
Sbjct: 586  LPGFVNLHSTETQTAGVIDR-----------------WELLQAQALSKELRMKQN----- 623

Query: 5496 LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLN-HVLALTAQSPDIEHLNEV 5554
            L +++ F   L S+   +   EE L++L + E       +   +  L      ++H   +
Sbjct: 624  LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAI 683

Query: 5555 SLKLPL------------SDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYC 5601
             L + L            S      L  MN +W R  +   E    LQ   +  + F   
Sbjct: 684  ILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEM 743

Query: 5602 CEKWIQLLEKIE----EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQ 5657
                + +LE I+    E + +D       L +  K    ++ E+  +Q    S    S Q
Sbjct: 744  SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 803

Query: 5658 LLDTTE 5663
            LL   E
Sbjct: 804  LLVNAE 809



 Score = 44.3 bits (103), Expect = 0.004
 Identities = 65/322 (20%), Positives = 128/322 (39%), Gaps = 27/322 (8%)

Query: 5625 PELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI------TEFSKLT 5678
            PEL    K Y  L  E S +    DS      +L +  E E+ P F+      T+ + + 
Sbjct: 549  PELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGVI 603

Query: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTR 5738
            DRW+        ++  +   +++WQ F + + +++ +L DT   L  ++  E  +  QT 
Sbjct: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663

Query: 5739 SL-IHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQ 5797
             L I +LK  +     R+    L++          D K    +  R+SQ+   W  +   
Sbjct: 664  ELQIKKLKELQKAVDHRK-AIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722

Query: 5798 LAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLP-------ELHEDLHNEKEL 5850
            L E     Q  +       +    L   L+ +  +  + +P       E+ +D H +   
Sbjct: 723  LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQ--- 779

Query: 5851 IKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQ 5910
            + +++  L      +  LQ M   L  +    D +  KE++  +  + + L   V+   +
Sbjct: 780  LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839

Query: 5911 EIEDRLNTWVVFNEKNKELCAW 5932
            E+E  L+     +   ++L +W
Sbjct: 840  ELEKLLDV----SSSQQDLSSW 857



 Score = 41.2 bits (95), Expect = 0.036
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
           W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665

Query: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
              +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 666 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 721

Query: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
           L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781

Query: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
              ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 782 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 829

Query: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
           LL++  + I+E E L  + +S Q
Sbjct: 830 LLKEVSRHIKELEKLLDVSSSQQ 852



 Score = 38.1 bits (87), Expect = 0.30
 Identities = 122/752 (16%), Positives = 279/752 (37%), Gaps = 88/752 (11%)

Query: 5020 ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQT 5079
            E+  + +   L +   +W  L+  +    +KL +  +      K ++ + +W+ ++E + 
Sbjct: 11   ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70

Query: 5080 SDEDSVHSPSSASQVKHLLQKHKEFRMEMD-YKQWIVDFVNQSLLQLSTCDVESKRYERT 5138
            + +  V+   ++ +++  L + +E + +++ +   +   +N   + L  CD  +   E  
Sbjct: 71   A-KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 129

Query: 5139 EFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQK 5198
               +    ++R+W  +  M   +   +E+      +  +      +WL++ E        
Sbjct: 130  SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 189

Query: 5199 PESVISVQKLLL--------DCQDIENQLAIKSKALDELKQSYLTLESGAV-PLLEDTAS 5249
               + +V K  L           +   QL + +K    L +   T  + ++  ++ +   
Sbjct: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249

Query: 5250 RIDELFQKRSSVLT-------QVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEH 5302
            R D L ++ +S+L        Q  + +T+  S+L  W        E+++        +EH
Sbjct: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSIL-VW------LTEMDLQLTN----IEH 298

Query: 5303 SKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC----PSVAEIIEEK 5358
                  S   ++ +++ L++ Q E   +     K++++I + + L     P  A IIEE+
Sbjct: 299  -----FSECDVQAKIKQLKAFQQEISLNH---NKIEQIIAQGEQLIEKSEPLDAAIIEEE 350

Query: 5359 -------CQNTHKRWTQVNQAIA------DQLQKAQSLLQLWKAYSNAHGEAAARLKQQE 5405
                   CQ    R  + ++ +       D+   +   L+L  + + +      R     
Sbjct: 351  LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410

Query: 5406 AKFQQLANISMS------GNNLAEILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ 5458
               Q  +N+S+S              P ++  I  E  HD   +++     S  L    +
Sbjct: 411  LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470

Query: 5459 PAESSTHMLLPG---------PLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESL 5509
              +      L G         P          E  +   + +   + SQ +  G  L+  
Sbjct: 471  EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530

Query: 5510 KGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ 5569
            +  I   E  +        E   S+  ++  L   S  I+ +  +  KL   + ++    
Sbjct: 531  RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 590

Query: 5570 NMNRQWIRATATALERCSELQGIGLNE--KFLYCCEKWIQL--------------LEKIE 5613
            N++    + TA  ++R   LQ   L++  +     +KW Q                E++E
Sbjct: 591  NLHSTETQ-TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649

Query: 5614 EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE 5673
            +  +++++  +  +  Q K  K L+  V   + I  S    S +       E+R +    
Sbjct: 650  QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDR 708

Query: 5674 FSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDF 5705
             S++  RW      + + +G +   + Q Q F
Sbjct: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 740



 Score = 37.0 bits (84), Expect = 0.68
 Identities = 57/288 (19%), Positives = 105/288 (36%), Gaps = 51/288 (17%)

Query: 5150 QWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLL 5209
            +W  +      K   ++Q L+   +  + +  +  WL   EE L+ LQ+ E    +Q + 
Sbjct: 605  RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664

Query: 5210 LDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLK 5269
            L  + ++       KA+D  K   L++     P      S+     Q R   L+Q+N   
Sbjct: 665  LQIKKLKE----LQKAVDHRKAIILSINL-CSPEFTQADSKESRDLQDR---LSQMNGRW 716

Query: 5270 TSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES 5329
              + S+L+EW+   Q                                 + L   Q   E 
Sbjct: 717  DRVCSLLEEWRGLLQ---------------------------------DALMQCQGFHEM 743

Query: 5330 SEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL-WK 5388
            S G    L+ +  +   + P  + +  E  Q+ HK+  Q+   + +   +  SL  +  +
Sbjct: 744  SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 803

Query: 5389 AYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436
               NA G      K++         + + GN L  +L    + IKEL+
Sbjct: 804  LLVNAEGTDCLEAKEK---------VHVIGNRLKLLLKEVSRHIKELE 842


>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform 2
            [Homo sapiens]
          Length = 429

 Score =  809 bits (2090), Expect = 0.0
 Identities = 415/430 (96%), Positives = 415/430 (96%), Gaps = 15/430 (3%)

Query: 6470 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 6529
            MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS
Sbjct: 1    MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60

Query: 6530 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI
Sbjct: 61   GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120

Query: 6590 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6649
            ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV
Sbjct: 121  ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180

Query: 6650 DSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 6695
            DSWRGGLRQSLMQCQ              DFHQLSQNLLLWLASAKNRRQKAHVTDPKAD
Sbjct: 181  DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240

Query: 6696 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 6755
            PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ
Sbjct: 241  PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300

Query: 6756 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETE 6815
            LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTEGEEETE
Sbjct: 301  LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTEGEEETE 359

Query: 6816 SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 6875
            SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM
Sbjct: 360  SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 419

Query: 6876 LRYTNGPPPT 6885
            LRYTNGPPPT
Sbjct: 420  LRYTNGPPPT 429



 Score = 40.8 bits (94), Expect = 0.047
 Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)

Query: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
            A I ++ +   DRW+ +         K+K+    +QQL+ ++S + TWL + E+EL    
Sbjct: 53   AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 109

Query: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
            +     D QEI+ R+   Q++ +  + + A V SV       L      + E      + 
Sbjct: 110  MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 169

Query: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
              + +  +     WR     S+ +    +   R    F  D+ +       WL SA+   
Sbjct: 170  SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 229

Query: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
                   P +        + EL + E   +++ ER  Q++++ +    L  +   +    
Sbjct: 230  QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 286

Query: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
             ++ VH   ++   L+ +V+  L  L+   N
Sbjct: 287  AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 317



 Score = 35.0 bits (79), Expect = 2.6
 Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)

Query: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
            ELH    + ++L   N D   +T WL+ ++  L   K        D+  I   +    E 
Sbjct: 73   ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 130

Query: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
             K  D   +L  +V     + L  +  ++  L++ L Q    W
Sbjct: 131  LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 173


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  234 bits (596), Expect = 3e-60
 Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)

Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
            +N I + + S     K  LPG  +Q  S++Q       E +QES       + +LE++  
Sbjct: 1012 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1071

Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
            + K    E+  S +                 N +  ++N ED R + +++  PLE D + 
Sbjct: 1072 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1129

Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
             +  ++ E EKL  +LE  K  +  +     E  ++    +          +VL N+   
Sbjct: 1130 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1189

Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
               S+ ++D L    + LK N ++   +++ ++  L   E    A++ DK +++      
Sbjct: 1190 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1238

Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
               +  +K++ + +++++     L+ + +       +M K   E  +          QL 
Sbjct: 1239 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1297

Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
              W+ V  QI  +      + +     +   +DT   L    Q ++   +  +E     S
Sbjct: 1298 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1353

Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
               L T L   K   S      E++MK+   ++ +K  E     +K             +
Sbjct: 1354 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1406

Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
            +Q K    R +M+ +         +L      L   +    +  K   D +   ++  +S
Sbjct: 1407 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1463

Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
            L EE K+ V      +   S+++ TL+D     +    K    S+++  K E+ S     
Sbjct: 1464 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1523

Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
            I+ F                      +QES  L+    + +++ + T  ++K     +  
Sbjct: 1524 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1583

Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
             Q+E +E   GI   L +  N    +   E   + D   +LK  + +   +Q+ +Q +  
Sbjct: 1584 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1641

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
             +   +K    F      L+E  + + Q ++ L+ Q++N+  +K E  NLK        D
Sbjct: 1642 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1695

Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
            ++  TAIK        + Q+ + K   + + L+W  S +D+   +   K K++   I+Q 
Sbjct: 1696 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1750

Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
             T F+E  GK         AI  + +    ++    D    + + N   L+Q+ +K K  
Sbjct: 1751 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1799

Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
             ++II   ++++    + +  ++L  K    L+ EE +KL K ++ + +  E +  E ++
Sbjct: 1800 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1856

Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
            K     + Q++LE       + +  LQQ    L NLE     I  +  +    ++F E V
Sbjct: 1857 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1916

Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
             +    ++ +T    +              + + S+   +V+ KL    D    L +  +
Sbjct: 1917 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1976

Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
            +  N L D  +    Y++A    +  + + EA     +  P  VD  N +  LE     Q
Sbjct: 1977 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2036

Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
             ++ S    ++ L +   ++     S   AK  +Q TL ++V +   + ++   +  + +
Sbjct: 2037 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2096

Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
              L      +   +++   +  +E+ L +    +PL+     + + ++  L  ++   + 
Sbjct: 2097 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2155

Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
             +  + + ++        +    L   +  L  ++       KE     EELK + +   
Sbjct: 2156 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2212

Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
                    + +NL E+L    +TK  A TE         ELS+ + +   ++ E+ +  +
Sbjct: 2213 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2264

Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
            +L +LL +   S   +P     V      ++  ++ ++  ++   +++ KE V +  ++ 
Sbjct: 2265 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2317

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
             +F   + +LK++ ++TT     +      E   +  E+ + + +K  L    I +    
Sbjct: 2318 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2377

Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
             I    + + V  PA+  + V+     L       + +E  +N+ L S        S  Y
Sbjct: 2378 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2437

Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
                  ++ KI E+N  L  ++K  ++ S  ++  Q++ K    W               
Sbjct: 2438 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2497

Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
                     EL    +K+ EL  ++ +++E++P   +A  W   L     ++Q+++Q   
Sbjct: 2498 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2557

Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
             R  +L +++  + ++  +    + W+     +++   P   D    L+     VQ+ L+
Sbjct: 2558 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2616

Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
            +   +      +    +  LS   E   L   ++E    VT     +   L       D 
Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2676

Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
             +   ++ +S+ + +S   + L +K     +   H       LE  + MK+ I       
Sbjct: 2677 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2729

Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  Q   K + V Q   + L  +   E +  E +  L+ ++K   + +++ EN  Q 
Sbjct: 2730 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2783

Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
            L +  A     + MS D    L   + E  +       L+   E L+ D K  +  L   
Sbjct: 2784 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2842

Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
             H+ ++      + L      E    +   +  K N       +   E +++ES  K+  
Sbjct: 2843 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2902

Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
              E+ E     W  + K   ++EE +                +  +NS+A++    SL  
Sbjct: 2903 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2945

Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
            E      +    N T        E D    +D    L  +V+      TE LH+ K  + 
Sbjct: 2946 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 3001

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
             +                    Q+  E Q         E+  +    L+  K+Q  + D+
Sbjct: 3002 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3033

Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
              +Q  +      L+T + +L+  K Q+ L ++ ++D    ++ ++S+ +    +    L
Sbjct: 3034 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3085

Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
             ++E+I  E    S+Q D ++   LE K      F   I    ++M+ Q+ + D++    
Sbjct: 3086 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3139

Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
                              ++P G++ +  Q     + + +K      +E  +++N     
Sbjct: 3140 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3176

Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
            +  M      T+ +L      LE L ++ + L  +    EE      K+L E +  L + 
Sbjct: 3177 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3235

Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
                  +L+    + E      +  ET+  +L    +   ++   L    + + W G+  
Sbjct: 3236 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3292

Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
                    +T  L    D++    +        R+  L+  L +   +Q+ ++ L   ++
Sbjct: 3293 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3352

Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
             ++  +  Q       + V  Q+Q+       L++ +S V  ++ EGE++        +V
Sbjct: 3353 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412

Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
              L+ +  LDS W  L      R  +L    V   Q    L+ + E +   +++L +   
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472

Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
                     +Q     AL+  I NH     + V+    ++  S++    ++Q++  F   
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3530

Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
            QV  ++I +EKS      LQ  L   + F E+   L   L  +   L  +S+ + + E L
Sbjct: 3531 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3589

Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
             ++ S  + ++ +I  +   + Q L  G +L+   +  E   ++ ++  ++ ++  + K 
Sbjct: 3590 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3649

Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
                   L+  L+     +   ++L  WL+  +  L  ++ Q L   +     +R     
Sbjct: 3650 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3706

Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
              E  KE     +L  ++  + + LL L        L   +A+  +++ ++   +    E
Sbjct: 3707 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3764

Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
            ++    +      +A    +SW+   E +      +      +  +  LQ  K F ME +
Sbjct: 3765 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3822

Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
             +K  I D V      ++ C  E K+  + +  + L           E   Q  R   ++
Sbjct: 3823 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3882

Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
            N+  +  E+L   +TE+++ I    + L A     +TL Q+ E    +++L+ + +   +
Sbjct: 3883 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3938

Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
            ++      L EL        ++ Y+  ++    + ED   R   +DE   + +    +++
Sbjct: 3939 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3998

Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
            Q+  S++ +++  +    +  EV  +  +    +  +K V + +E L+   E L+   +E
Sbjct: 3999 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4054

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
              +  G  +K               A+ +++K       W  ++  + ++  K   +++L
Sbjct: 4055 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4102

Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
             + +   H      +K  +   + L +  +  + + +    A + I+E    +Q+  +  
Sbjct: 4103 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4161

Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
            +   S L        +P    +   L     SL +A       LE+ +            
Sbjct: 4162 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4221

Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
             F++V      L+     G  LE++K  I   ++     +QQ+ E     LNH   L   
Sbjct: 4222 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4277

Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
               ++ + E S K  + D     L  +   W       + R  +L+G  L   +F +  +
Sbjct: 4278 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4330

Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
            + +  L   E  L         P+ +E +   + +L+ +V  +Q+  ++       L+++
Sbjct: 4331 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4390

Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
            +  E       +   L  RWQN ++   QRK  +DG +RQ + F   +E+L ++LTDT  
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450

Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
             L A K      L        E  N  +     F+ +  T    ++ G+++L       +
Sbjct: 4451 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4505

Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
             ++ + I+ L++ W+ +E +L E   + +  +    E  +  +  I  L    Q L   S
Sbjct: 4506 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4565

Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
               L  + + +  + +  K     + S  + + EL      L      +DV+++K  +  
Sbjct: 4566 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4623

Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
            +  +WE +  R+  R + ++D       F+E   +L  WL + E  +    +I+ +    
Sbjct: 4624 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4683

Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
            K Q    K+  + +           + G  L  K S      ++DD L+++ D+W  +  
Sbjct: 4684 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4743

Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
                R  KL+E   F  Q    +  L  WL R+E +L+  +PV  D+     +   +   
Sbjct: 4744 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4800

Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
            +  Q+++ + ++ V+++      L+  S       +   ++   + L  RW  +CA+S+ 
Sbjct: 4801 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4855

Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
            ++ ++E   R  ++F        +WL  AE+T       P+  + L T     + + + F
Sbjct: 4856 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4911

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
             +++ E+  +L         +      D+ + +K  +     R++ +        +RL  
Sbjct: 4912 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4971

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
                    +   E++L WL   +  LT+ +        ++++ L      F +E+T    
Sbjct: 4972 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5031

Query: 6299 KIDQL 6303
             +D++
Sbjct: 5032 DVDKV 5036



 Score =  197 bits (500), Expect = 4e-49
 Identities = 113/266 (42%), Positives = 148/266 (55%), Gaps = 35/266 (13%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT WIN  L +      ++DL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 61  ERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 118

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +L+ R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 119 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 169

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  MSA++ LLLW Q+    Y  +   +F 
Sbjct: 170 -------DIHVTGESE----------------DMSAKERLLLWTQQATEGYAGIRCENFT 206

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           + WR+G  F AIIH  RPDLIDM +V  +SN  NL  AF +AE ++ + RLL+PEDVDV 
Sbjct: 207 TCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPEDVDVS 265

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE 293
            PDEKS++TYV+         P  GE
Sbjct: 266 SPDEKSVITYVSSLYDAFPKVPEGGE 291



 Score =  193 bits (490), Expect = 6e-48
 Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)

Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
            N  EE  N  FV   L+  D   +Q    ++ +    +   ++  ++  +A+E+F +SL+
Sbjct: 626  NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 685

Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
             AK+          S+ Q+     LT   K   +H ++       +  K+L+ S ++ ER
Sbjct: 686  EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 725

Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
              DT    +  A +  I L+E     V  +++E N  +      + EL++       NI+
Sbjct: 726  HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 785

Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
             VQ    ++ L++    +    +R     +   +L   +  ++H++E       F D +E
Sbjct: 786  SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 845

Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
             T               C  +  +    + LV E +E+   +L+      N      T+I
Sbjct: 846  ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 904

Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
            Q     S   L+ S   K     R  EI I K++      N H     K   +       
Sbjct: 905  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 961

Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
            +     F  PP  KEA       +D+  + E  Y+N+   L LW +   N+K+V+  W  
Sbjct: 962  MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 1009

Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
                    + + E DR R      +      E  + ++ +Q   +   E   E QV   S
Sbjct: 1010 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1061

Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
             + ++E  V  C               +  ++L ++  +    ES+   L  S+   I  
Sbjct: 1062 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1106

Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
            +LE  + ++++Q  + +    L   +  +T E  +LKK+ E + D   T  +  ++ FS+
Sbjct: 1107 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1165

Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
               +          + +  N+ + +  S T                      K+K V+ V
Sbjct: 1166 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1206

Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
            LK+ +  + L K +  +L     ++  +  +E + S  +    E+++  Q    L+D+  
Sbjct: 1207 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1264

Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
             L+K     +E +K  +E     +   +   +  E++++V  Q++N L++  G  +  + 
Sbjct: 1265 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1323

Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
              +    +D    + +T  R++ E + E  K L T+      L  ++     E+K+S M 
Sbjct: 1324 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1377

Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
                E +   E+    +K+  L      A +++     + ++   S A L+ +   D+  
Sbjct: 1378 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1434

Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
            ++   + L + Y          L  +EK L E +K +++  ++L+  +      LK  ++
Sbjct: 1435 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1494

Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
            AG       +    ++   K+ L +A     L   L   G+ + +  +N    +   L+ 
Sbjct: 1495 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1552

Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
             +  L    L+QLQ+S  + D  V         +E+      + DL T  +N     +E 
Sbjct: 1553 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1612

Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
                D  V+    + K ++LQ+         G+ + +  + K+ +      G+K+ ++D 
Sbjct: 1613 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1665

Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
            K+L      +E +L  AK +   C    LK+++S ++         +K  T+ ++E T++
Sbjct: 1666 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1708

Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
             AAV++LEE         DW  N D   E A +K   +  Q          +S    EDE
Sbjct: 1709 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1768

Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
               N L+    ++D  +   Q E + + Y +++A+   I    Q   +  T++  ++L  
Sbjct: 1769 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1823

Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
             G   S +  + L + +  LK + E+           LA  E  MK   + +E L+    
Sbjct: 1824 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1873

Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
            D   +   L + ++ + ++E   D +  L  K        E++ +H      +T    ++
Sbjct: 1874 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1933

Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
            LE+     +    +V+     +++Q+K       +    +  N + +    L  + QH  
Sbjct: 1934 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 1993

Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
                 L   L++ E  A       +  D   LQ        L+GQ   Q   +   K+  
Sbjct: 1994 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2053

Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
                         K +++  ++++  ++E L     E   ++     +   +++ + E +
Sbjct: 2054 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2113

Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
             W  N+   L     +PL    +   I K  +    I  RQ S+ ++ E+VK  + +   
Sbjct: 2114 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2173

Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
               S L   ++DL  ++     K  +   ++E +L+ +   F  + +      E++T  +
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2232

Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
              V+    +            +E   H   LE     L+EI S G+ +   +   + E+ 
Sbjct: 2233 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2289

Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
            N   + F  +ED +K  K      Q  +      V+    + ++  +K   +Q       
Sbjct: 2290 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2349

Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
                 E+   +Q    L   E+    N G+   + NL   +T     I  V     V + 
Sbjct: 2350 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2407

Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
             G          N   + + +  T +    ++    L++KI +L+T   +  K Q    +
Sbjct: 2408 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2464

Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
              A+   ++KM +   K           A  +  E  +     L Q + K + L D++ +
Sbjct: 2465 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2524

Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
             L EN    ++ + K++L       E D  ++ L  + ++   K  +  N   + +T   
Sbjct: 2525 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2578

Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
             L Q  ++ +L   +L  ++++   +  ++   +   ++        + +TA    I  +
Sbjct: 2579 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2638

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
              E+ S    V+ +L         L   +  R + ++ A    T+Y+  +    + ++ L
Sbjct: 2639 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2698

Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
            +     ++ +    D  N  + LE   + ++E++     I   Q L E L       A +
Sbjct: 2699 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2750

Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
            + +Y   EL  +   + ++FK  E +AE ++++ +        +++M  D     + ++T
Sbjct: 2751 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2807

Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
               +   S P+S + + LE L     + SK L +     ++ + +   +  LL+ + +E 
Sbjct: 2808 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2865

Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
              + L L  +   W+                     K+   +E    W   C+   +E K
Sbjct: 2866 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2925

Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
            F  +  E E  I  L +LQ+E+ +                 + +  +   T+E   L+  
Sbjct: 2926 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2985

Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
            +    E +  ++  L  + Q+ +  Q V + S      A E +     + S     +   
Sbjct: 2986 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3045

Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
            +LQ  QK+ + ++ ++       ++++   +  + T+     +    Q+H   S+Q +E 
Sbjct: 3046 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3105

Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
             S L+   +G   F+N + ++  +++E    +   A +    E  +K  E I   +   E
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3165

Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
             L +S   A     M    EE +  L     ++E + +Q +K +++AQ  ++++      
Sbjct: 3166 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3225

Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
            L+ ++SKL E    +Q   E +  Q    M+   I                P Q  QQ  
Sbjct: 3226 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3285

Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
                                             ++++   R +QL +A +    + D L+
Sbjct: 3286 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3345

Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
            S  +W+ +T  L+AN     A++  ++        +Q  L+D   + + +  I  + E +
Sbjct: 3346 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3402

Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
            +   E  +  + +++LS   ++  AL  K      Q++ ++         ++ + + ++ 
Sbjct: 3403 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3462

Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
            I+  L++ E         EE +   + + ++I    K + + VS    L++  +      
Sbjct: 3463 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3522

Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
            V  + +        ++  +  ++ELL+  +     + E+   L   LN    + S   + 
Sbjct: 3523 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3582

Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
                + L + Q E+  +++ IL   Q  +  L++    LK T  +    ++ + E + + 
Sbjct: 3583 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3641

Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
            R   +T     VA+      +L RR         ++L  VE E+     +   G+E  +A
Sbjct: 3642 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3701

Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
            +  P+      K++K + +     SS  +       +E   K+   DN   ++++   + 
Sbjct: 3702 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3761

Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
              E+     LR  Q ++            ++DA+       EK               + 
Sbjct: 3762 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3798

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            ++ L   Q +  ++       +Q+    +++  + ++ ++      ++  C ++      
Sbjct: 3799 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3845

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
                E +++  KL  V  N + +  +  E++ + +    L       ++E L P  L+E 
Sbjct: 3846 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3899

Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
            +SI+++ P      +  RQ+  + +Q+ EL   E K  I        K  PQ  +    +
Sbjct: 3900 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3954

Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
              + QE   +A    S  + DV       D  +S   Q  DK   +   L   + +L  P
Sbjct: 3955 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4014

Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
                   + ++ Q+S N  +   +      Y T ++                  K    +
Sbjct: 4015 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4074

Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
            L+ +     N+ T     E   ++   L +K +     L +T+      + + LE P + 
Sbjct: 4075 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4133

Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
                  QQ   ET+  E+  L   L    +   +L+ A   P  +  ++ +  D L    
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4191

Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
            +    A   R   L+  +     YQ+ ++ ++  +      + S + +   L  +  Q  
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4251

Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
              +  K++AY  ++E       AE  + K+ +E ++    + +   + +L+ + DS+   
Sbjct: 4252 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4307

Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
            +  R  +L    +   Q Q AL + +  L      + ++K   G  K  + ++A    ++
Sbjct: 4308 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4367

Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
            N  +  Q  V     A   LI++ SA    S LQN+     ++   V    EK+ Q   +
Sbjct: 4368 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4423

Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
            L   L++ + F      L++ L      L+++ P   L E  +E+L    + + ++    
Sbjct: 4424 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4479

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
              K       + +G+Q++A   CP+     ++  I  L+E+W S+  K++    +L+  L
Sbjct: 4480 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4537

Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
               + ++        WL  ++ TLN     SL     LDT+   I+    F+ EV   +S
Sbjct: 4538 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4590

Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
             +  +I +     HLK    + D   ++  L   + +W  ++ +L +    L   +    
Sbjct: 4591 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4650

Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
               +A ++++ W+   E + S +  +   +   ++K  L +HKEF+  +  K  + D  N
Sbjct: 4651 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4708

Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
            ++   L   +  S   +  +  + L E+  +W  + G    +   LE+ L    +  + +
Sbjct: 4709 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4766

Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
            Q L +WL   E +L   Q     I  V  L+ + +  + +L  ++ ++  LK+S   L  
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4826

Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
            G+     D +S +    Q+ S+    V  L  S Q+ L+      + +  V    + +  
Sbjct: 4827 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4880

Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
             +  ++  +     L    + L++L D+ +      E+ +  + K   +  +V  I    
Sbjct: 4881 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4939

Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
               T K W  + +A  +++       Q   A + A   A   L +    + Q A  +++ 
Sbjct: 4940 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 4999

Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
             +  E++P  ++++K L  + Q   E   +    +D++
Sbjct: 5000 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036



 Score =  183 bits (464), Expect = 6e-45
 Identities = 676/3660 (18%), Positives = 1402/3660 (38%), Gaps = 447/3660 (12%)

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
            +E L+   R+++E      +I ++      + + E +L  Q  ++  + ++   +  F+ 
Sbjct: 1078 QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ--IRTPLERDDLHESVFRI 1135

Query: 3350 QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPL-SYREALERLEQSKALVS 3408
             E E  +     K   ++++D+ T  +K E    Q+ +S  + + R  L  + Q+   V 
Sbjct: 1136 TEQEKLK-----KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1190

Query: 3409 NLISTKEELMKLRQIL--------RLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEW 3460
            ++ ST  + +K   ++         L++L  T+   +C  + V A      +L+   K+W
Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK---LCEEEAVIADKNNIENLISTLKQW 1247

Query: 3461 EMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGEN 3520
                +E +Q +  + +E+++   I D + +   E          +   E  D L +  +N
Sbjct: 1248 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE-----RDLDFDWHKEKADQLVERWQN 1302

Query: 3521 VEKQQLLLTLLLQRIRSIQNVPESSGAVETV--PAFQEITSMKERCNKLLQKVQKNKELV 3578
            V  Q      +  R+R ++ + +S         P    I  ++    K+ +   +N + +
Sbjct: 1303 VHVQ------IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1356

Query: 3579 QTEIQERHSFTKEIIALKN-------FFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKG 3631
             T++ ++     EI   ++       + +Q + + ++   Q    ++    + +S +K+ 
Sbjct: 1357 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1416

Query: 3632 K------LTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPS 3685
            +      L  +  M+ LR +Y+ + T++   I+   +  ++  E+  EK   E  K    
Sbjct: 1417 RMQSSADLIIQEFMD-LRTRYTALVTLMTQYIKFAGDSLKRLEEE--EKSLEEEKKEHVE 1473

Query: 3686 YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQ--- 3742
                 K +E+   + N+ K L+   K  +     QK   +E+     +L+E    +Q   
Sbjct: 1474 -----KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1528

Query: 3743 -----DIVEQDPGQAQEWMDNLMIPFQQY--QQVSQRAECRTSQLNKATVKM-----EEY 3790
                  + +++  + ++ +  L   +     + + Q  E +TS   K   K+     +EY
Sbjct: 1529 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEY 1588

Query: 3791 SDLLKSTEAWIENTSHLLANPADY----DSLRTLSHHASTVQMALEDSEQKHNLLHSIFM 3846
             + L+     +  T + L    +     D    L  + S  +   +D +     L  +  
Sbjct: 1589 KEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVK 1648

Query: 3847 DLEDL-----SIIFETDE--LTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESE- 3898
            + E+        + + D+  + Q + E   +   L  K  +S  ++ ++    +  E+E 
Sbjct: 1649 NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1708

Query: 3899 ---VKSMEKRVSKIKTIL--LSKEIFDFSPEEHLKHGEVILENIRPM-----KKTIAEIV 3948
               VK +E+  +KI+ +L  LS    D S     KH +VI +N         K  I E  
Sbjct: 1709 VAAVKQLEESKTKIENLLDWLSNVDKD-SERAGTKHKQVIEQNGTHFQEGDGKSAIGEED 1767

Query: 3949 SYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLEN--VTQEQNELL-----KVVIKQTNEW 4001
                 L       +     +  NQ  Q +K      ++Q Q  ++     +V++++  ++
Sbjct: 1768 EVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY 1827

Query: 4002 --DEEIENLKQILNNYSAQFSLEHMSPDQADKLPQ-LQGEIERMEKQILSLN---QRKED 4055
               EE E L++ +      +       ++  KL   LQ E+E+ +          Q+ E 
Sbjct: 1828 LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1887

Query: 4056 LLVDLKA---TVLNLHQHLKQEQEGVE-----RDRLPAVTSEEGGVAERDASERKLNRRG 4107
             L +L+A    +  L   LK+++   E     +  L  +T     V E   S  K  R G
Sbjct: 1888 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSK--RDG 1945

Query: 4108 SMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEE--DRASSSSGTIVQE 4165
                 +A   EV+    K D+  ++        + L  + KD+ +       +S  ++  
Sbjct: 1946 GKVDTSATHREVQR---KLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAG 2002

Query: 4166 AYGKISTSDNSMAQILTPDSLNTE---------QGPECSLRP-----NQTEE------GT 4205
                 +T+   +++ +  D  N +         QG   S +       +T E      G+
Sbjct: 2003 LQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS 2062

Query: 4206 TPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQ-------VAELELWLQQANVA 4258
              P + D   + D   G    + K+  E  E L    T+       + E+  W+     +
Sbjct: 2063 LLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESS 2122

Query: 4259 VEPE---TLNADMQQ-------VLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGAT 4308
            ++ +    LN+   Q       +LEQ + G Q+ +  +  KV   +ET            
Sbjct: 2123 LKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS-------- 2174

Query: 4309 QHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSE-LE 4367
               A +L  K+K +     +       KH E    T+ K        E  +  NLSE L+
Sbjct: 2175 --TASSLQAKMKDLSARFSEAS----HKHKE----TLAKMEELKTKVELFE--NLSEKLQ 2222

Query: 4368 SIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAK-----KMWPQYCQHD--NDT 4420
            + +  + Q   + D   + V EL    Q+   +F+E          +  +   H   +D 
Sbjct: 2223 TFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2282

Query: 4421 TQESSASNQASSPENDVPDSILSPQG------QNGDKWQYLHHELSSKIKLPLPQLVEPQ 4474
                  +N  S    ++ D+I   +       +  D +Q L   L S IK    ++  P 
Sbjct: 2283 ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PI 2340

Query: 4475 VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNL-QTQENMTEEAYINLDKKL 4533
            V  + G               E+    T +++ +     +L      +T  A      K 
Sbjct: 2341 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2400

Query: 4534 FELFLTLSQCLSSVEEMLEMPRL--YREDGSGQQVHYETLALELKKLYLALSDKKGDLLK 4591
                L      ++ EE      L   ++D +     YE L L LK     L+ K   L K
Sbjct: 2401 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK 2460

Query: 4592 AMTWPGENTNLLLECFDNL-QVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
            A     E ++ +++    + +   +  Q  A   ++++K  ++ N+S++ E+K+  +++ 
Sbjct: 2461 AQ----EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2516

Query: 4651 KSKTSLQQSLNEISGQSVA----EQLQKADAYTVELENAE-SRVAKLRDEGERL---HLP 4702
            + K  L + L E      A    + L + D+   EL      R  KL +    L      
Sbjct: 2517 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2576

Query: 4703 YALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA--- 4759
             A L++    ++++ S+ G L      L+    T+ QQ  +L       K   E+L    
Sbjct: 2577 EAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKPQYEQLTAAG 2632

Query: 4760 HGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
             G L +     +L+            +V + L         L   L +R   W +Q    
Sbjct: 2633 QGILSRPGEDPSLRG-----------IVKEQLAAVTQKWDSLTGQLSDR-CDWIDQAIV- 2679

Query: 4820 KILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVE-ETEERLVERI 4878
                 KS Q    L+SL  K  + D   +S      + +ST P     + ET +++ + I
Sbjct: 2680 -----KSTQYQSLLRSLSDKLSDLDNKLSS-----SLAVSTHPDAMNQQLETAQKMKQEI 2729

Query: 4879 SFYQQIKRNIGGKHARLYQTLNEGKQLVASVSC--PELEGQIAKLEEQWLSLNKKIDHEL 4936
               QQ K+ I     ++ Q L E    +        EL  Q+  + + +  + +K ++ +
Sbjct: 2730 ---QQEKKQI-----KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHV 2781

Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
              LQ+       + + S     WL++ +   N    +S  +S  LD + S I +  +FSK
Sbjct: 2782 QHLQSACASSHQFQQMSRDFQAWLDTKKEEQN----KSHPISAKLDVLESLIKDHKDFSK 2837

Query: 4997 EVDEKSSLKTAVISIG-NQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
             +  +S +    I+ G N LL  + ++ A L+  L   +  W     Q+ + + KL +  
Sbjct: 2838 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2897

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
             + L  ++ +  +  W++  ++   +      P+     ++ + K K  + EMD    +V
Sbjct: 2898 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG---ENSIAKLKSLQKEMDQHFGMV 2954

Query: 5116 DFVNQ---SLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESI 5172
            + +N    SLL +   D E    E     + +  +  Q H     L    Q  ++  E  
Sbjct: 2955 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 3014

Query: 5173 TESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQS 5232
             ES+ ++Q     L+  +         + +  +Q      Q +++Q+ +  +   +L   
Sbjct: 3015 KESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL--- 3071

Query: 5233 YLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMM 5292
               +E+       D   +++ + Q+ S++  QV++  + +++ LQ    +     E+   
Sbjct: 3072 --VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3129

Query: 5293 TIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---SEGSWEKLQEVIGKLKGLCP 5349
               F   ++   PV    ETL+ Q E +++   + E+   S  +  K  +++   +   P
Sbjct: 3130 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3189

Query: 5350 SVA------EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQ 5403
             +       E + ++C     R     + +   +++ +      K +S    +A    + 
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3249

Query: 5404 QEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESS 5463
            Q     +   I+   N         ++ ++  Q DV    +  +Q++         A+S+
Sbjct: 3250 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA---------AKST 3300

Query: 5464 THMLLPGPLHSLQ-RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDR 5522
            +   L   L  +  R   L K +  +A + +  L     F   LESL   ++  EE +  
Sbjct: 3301 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3360

Query: 5523 LHQQEKE--------NPDSFLNHVLALTAQSPDIEHLNEVSLKL-----PLSDVAV-KTL 5568
                  E             L  +L    +   +E +     K+     P   V + K L
Sbjct: 3361 QKPPSAEFKVVKAQIQEQKLLQRLL--DDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3418

Query: 5569 QNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEALK--VDVANSLP 5625
              ++ +W      A  R  +L+GI +  ++F    E   + L  IE+ L     +     
Sbjct: 3419 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3478

Query: 5626 ELLEQQKTYKMLEAEV-----SINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
            +L EQ   +K LE ++      ++Q ++   + QSL++L + E ++  +   +FS++   
Sbjct: 3479 KLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDFSQV--- 3532

Query: 5681 WQNAVQGVRQRKGDV-DGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFS--LYQT 5737
            W   +Q     + ++    +   + F      L  +L +    LS +  Q+  +  L++ 
Sbjct: 3533 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3592

Query: 5738 RSLIHELKNKEIHFQRRRTTCALT--LE-----AGEKLLLTTD-LKTKESVGRRISQLQD 5789
            +S +  L+ ++I  +++    AL   LE      G+++L+  D L+  ++  + I++L  
Sbjct: 3593 QSELRVLQ-EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3651

Query: 5790 SWKDMEPQLAEMIKQFQSTVE---TW-DQCEKKIKELKSRLQVLK----AQSEDPLPELH 5841
                   Q  ++ ++  ST E   TW D+ E ++  L    QVLK    +Q++    EL 
Sbjct: 3652 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL--LSYETQVLKGEEASQAQMRPKELK 3709

Query: 5842 EDLHNEKELIKELEQ------SLASWTQNLKELQTMKADLTRHVLVEDVMVLK-EQIEHL 5894
            ++  N K L+  L +       L  W       + +  D  R+ LV D +  K E+I+  
Sbjct: 3710 KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-- 3767

Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEK 5954
                        +R Q+          F++      +W+ + E K++   DI +E+    
Sbjct: 3768 ---------AAILRSQQ----------FDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3808

Query: 5955 LQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-------EIDDKLNKINDRWQHLF 6007
             Q   ++    F+   L+ K + D L+K+ +K   A        +  KL+K+   +  + 
Sbjct: 3809 AQ---LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTIC 3865

Query: 6008 DVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ 6067
             +   R  +L+   + + Q  +    L  WL   +S +S+ +     + + ++++  E +
Sbjct: 3866 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPALEYETLRQQQEEHR 3924

Query: 6068 DLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMER 6127
             L+  I +H   ++ +      LL  S       E  SIQ+   + D  +  I     +R
Sbjct: 3925 QLRELIAEHKPHIDKMNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKEDVKKR 3979

Query: 6128 RMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIH 6187
             + ++E      +F D   +  + L+        P S        KE++   +     + 
Sbjct: 3980 AVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME 4039

Query: 6188 ERLTQLELINKQYRRL-ARENRTDTASRLKQMVHEGNQR---WDNLQRRVTAVLRRLRHF 6243
            +     E + ++   + AR   TD     K +  + +Q    W+N+   V     +L   
Sbjct: 4040 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4099

Query: 6244 TNQREEFEGTRESILVWLTEMDLQLTNVEH--------FSESDADDKMRQ-LNGFQQEIT 6294
                E+F     S++V + +    + ++E           + +A + +R+ ++G Q+E+ 
Sbjct: 4100 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4159

Query: 6295 LNTNKIDQLIVF----GEQLIQKS--------EPLDAVLIE--DELEELHRYC------- 6333
            +  N   +LI       + +++KS        + L+    +  D+LEE  +         
Sbjct: 4160 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4219

Query: 6334 QEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPS-SPQS 6392
            Q VF  V     +L S +P   D +   +    +E+ ++ ++++++++ E E  +   + 
Sbjct: 4220 QAVFDWVDIAGGKLASMSPIGTDLETVKQQ---IEELKQFKSEAYQQQIEMERLNHQAEL 4276

Query: 6393 LCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGH 6452
            L   V    ++   + P+    + L WD   +   +  H+          L G  ++ G 
Sbjct: 4277 LLKKVTEESDKHTVQDPLM--ELKLIWDSLEERIINRQHK----------LEGALLALGQ 4324

Query: 6453 SWHVPDSPSCPEHHYKQMEGDRNV----PPVPPASSTPYKPPYGKLLLPPGTDGG--KEG 6506
              H  D       H + +  ++      P         +      +L    T     K G
Sbjct: 4325 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4384

Query: 6507 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQ---LNSDISAI 6563
              ++  +  +E   L    E  +    RW+ +  +    K ++   L+Q    + +I  +
Sbjct: 4385 NDLIESSAGEEASNLQNKLEVLN---QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDL 4441

Query: 6564 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 6623
              WL  TE  L   K      +  + +L V    E+  AF+  +    S+    ++ L  
Sbjct: 4442 QQWLTDTERHLLASKPLGGLPETAKEQLNVH--MEVCAAFEAKEETYKSLMQKGQQML-A 4498

Query: 6624 ESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6681
              P+S E  +   +  L   WE+ +  ++  +  L ++L    +FH   Q+ + WL  A+
Sbjct: 4499 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4558



 Score =  181 bits (458), Expect = 3e-44
 Identities = 668/3660 (18%), Positives = 1377/3660 (37%), Gaps = 503/3660 (13%)

Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
            E +LEN+K   +  E+  ++L + +    Q  + L L+Y E L RLE   A    L++T 
Sbjct: 664  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 720

Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
                +    L     R T             +W       E A +W      + ++ K  
Sbjct: 721  RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 769

Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
              E+ RE   LD  +E +  + +  E    E     L  +  Y   ++ Q   +  L Q 
Sbjct: 770  HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 825

Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
            +   Q++ E++   E     +E T         +Q+         + K ++LVQ  ++E+
Sbjct: 826  VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 883

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
                +    + N   +  T  Q       P  S+          K  +  + I +  +I+
Sbjct: 884  EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 931

Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
                 TI   +         +A   +     NE +  S  +     +   N    ++   
Sbjct: 932  I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 983

Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
            ++Q+ +N+             +  WH  +NE+D    S V  I    PG+ Q+ + NL  
Sbjct: 984  IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1043

Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
             F+ + + SQ ++  +    +QL K   V  + Y +LLKS E   +  S      ++  +
Sbjct: 1044 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1103

Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
            +R  L +    +   +    ++ +L  S+F   E   +  E + L   +  ++N+     
Sbjct: 1104 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1163

Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
             Q     S+P ++   + V+   ++V SM    + K+KT+ L      + E      E  
Sbjct: 1164 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1223

Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
            L   E ++ +   ++  I+ +  ++ E+       +   VF      LQ  K + +    
Sbjct: 1224 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1273

Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
              E+ K   ++  ++D   E   Q++  +       H+  D  ++L  L+G I +  K  
Sbjct: 1274 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1324

Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
                   +D +  ++ T     + +++ Q    +     +  ++  V+E +  + K++  
Sbjct: 1325 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1380

Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
            ++ +  Y A V++ E++  + ++    ++  P              ++  R  SS+  I+
Sbjct: 1381 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1426

Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
            QE +  + T   ++  ++T       DSL   +  E SL   +                 
Sbjct: 1427 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1485

Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
                   E+   PP     + S +     E   E                T  E  E+  
Sbjct: 1486 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1545

Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
              KT      L   ++           +V VE E + A+ QQ  +++L G   +LT+ E 
Sbjct: 1546 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1604

Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
                H+ AF++     E  K Q   +    Q + +  +  L  V  N E       EK S
Sbjct: 1605 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1662

Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
            ++    I +K +E + +   + +NL       EL+ +VT   +   +K    +Q+ E K 
Sbjct: 1663 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1720

Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
              +   D++  ++ ++++   ++ Q    N T  +      A   E++V          N
Sbjct: 1721 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1770

Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
            G+                   L+E  V   +G                     TTQ E+L
Sbjct: 1771 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1789

Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
             Q+   ++ Q    +++   + +  +  ++ L       S EE  ++ +  +E     +V
Sbjct: 1790 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1845

Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
            HYET         LA S+KK  L  ++          LE FD      EH    +    +
Sbjct: 1846 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1890

Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
            +L+AG D       ++KR       +I  K  L+     ISG  V   A+   K D   V
Sbjct: 1891 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1948

Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
            +       V +  D   +R    Y+    +   L+D++D         Y + S   +   
Sbjct: 1949 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 2003

Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
            Q  +    + + E + +  + L    L++TK   ALQ QI + +V  +KL     ++   
Sbjct: 2004 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2059

Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
               +LP+    ++T   + V   + L +   +   KLQ  L +     +    +   +  
Sbjct: 2060 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2118

Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
            + S+L     V      L + IS    ++++I G+ + +     + K+ + +    +   
Sbjct: 2119 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2178

Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
            L+ ++  L  ++   + K    L +++ L   +  +   S++L  +LE+    L      
Sbjct: 2179 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2238

Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
              +V++    ++ + + F E  K ++   SL   + S      H   +D A +       
Sbjct: 2239 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2292

Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
             +K+  +   + + +E +   Q +    +  +  + SW+     +T+ +  +  PS  A 
Sbjct: 2293 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2348

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
             +   L+  K+ + +   K   +  VN S + L                     +  + E
Sbjct: 2349 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2408

Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
                   EF  + G         +++  +  +  +L  KI  L   L  + +++ +   +
Sbjct: 2409 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2468

Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
              WL+   +     Q+   P    +V+  +   +  E +L      + ELK     L   
Sbjct: 2469 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2528

Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
              ++   P  +   + ID  +Q+       R   L + +   T  Q+V   L++W +  +
Sbjct: 2529 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2588

Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
            L   V               P+ +    L  Q + +Q L  E  + +  +E+L    Q +
Sbjct: 2589 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2635

Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
            + +  G  PS+  I++E+     ++W  +   ++D+       +     Y +     + +
Sbjct: 2636 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694

Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
            L   + K      +S   + + + L  A +  +E+Q + ++ K  +A  ++ S L +  +
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2753

Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
              ++     L G L S     Q+A  +++ +    A+  +F     +DF   L++ K   
Sbjct: 2754 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2809

Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
              EE+N        LD L    K++ D        LTAQS   E        + LK   S
Sbjct: 2810 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2863

Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
            + A   LQ   +   W        ER ++L+     EK L   E+      WI   +   
Sbjct: 2864 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2921

Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
            E +K      +  NS+ +L   QK        V +    A+S       LL   EI+   
Sbjct: 2922 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2972

Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
            E +T+ +K L  +     + +  +K  ++ + +++++F    +   R L      L    
Sbjct: 2973 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3032

Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
            ++  Q   + Y T   + + + K +   + +   A  L A + ++  +D K    V  ++
Sbjct: 3033 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3088

Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
              +      +  Q+ E     ++ ++     +  I+E+ S+      +  S  P+    E
Sbjct: 3089 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3148

Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
             L  +KE IK   + L A    N    +T K  L       D++ +K  +E L +Q   L
Sbjct: 3149 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3208

Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
              R   R++++E  +     F  K KE    L + E        + +E         M +
Sbjct: 3209 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3268

Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
              QK   EEI      +  +  +G  LI+++ KS + + ++  L+ +N RW+ L   +  
Sbjct: 3269 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3325

Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
            R  +L+E      +    + +L +W+   E EL         + + ++ ++ EQ+ LQR 
Sbjct: 3326 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3384

Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
            ++   + VE       V+  + +  A   E  D ++  +    LD RW  +   +  R  
Sbjct: 3385 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3437

Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
            ++E    + Q+F +      +WL + E+            +  +E++ + +A +  I   
Sbjct: 3438 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3497

Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
            ++ L Q   I +  + L+ RE++    S+L     + +Q W   +Q +  +    L+   
Sbjct: 3498 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3552

Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
               + F      ++ WL E+  +L+  +V+ +S      +  +L   Q++I L    +DQ
Sbjct: 3553 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3612

Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
             ++ G +L++++   + ++I+D+LE +    +++            +  +  RRL S   
Sbjct: 3613 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3672

Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
              CT   + E E    ET +            P+E++ ++   +   +  +   S    +
Sbjct: 3673 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3732

Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVP 6457
             P   R G E  V+ D+   E         +   EE +     S    ++     SW   
Sbjct: 3733 VPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3789

Query: 6458 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6517
                       ++E D+    +    +   +    K ++    D  K G +++    ++E
Sbjct: 3790 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII---DDLVKSGHKIMTACSEEE 3846

Query: 6518 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6577
               +    ++    +D    I ++      + +  + Q       +  WL +T++ +  L
Sbjct: 3847 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3906

Query: 6578 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
                P  + + +  + +  +++ +    +K  +  +N +  + L+    E   +Q +   
Sbjct: 3907 --PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3964

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADP 6696
               L+   +  V      L +++ Q   FH     +L  L     R RQ   ++   A+ 
Sbjct: 3965 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS---AEV 4021

Query: 6697 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              + E   E   +  ++ + QP  + L++    ++ +  G D    +     ++ KL Q+
Sbjct: 4022 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD---KDISAKAVQDKLDQM 4078



 Score =  174 bits (440), Expect = 4e-42
 Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)

Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
            LQ Q E  K F +KL A ++     + K    +L   ET   + V   + LE  S+QC  
Sbjct: 3150 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3206

Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
                LL + +  +E      K LE   S L   S+       L+++   +++ +  +G +
Sbjct: 3207 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3256

Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
               + Q LN             +GKQ                S S   LE  +  +  +W
Sbjct: 3257 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3316

Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
             +LNKK+     +LQ  L H   +    + L  W+  ++  +   K  S     +   ++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3372

Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
            + I       + +D++ S    +   G ++    E  D   +   L+  + +W  L+ + 
Sbjct: 3373 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3432

Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
                 +L  + +      + +  +  W+  +E +  + + + +   AS+++  + +HK  
Sbjct: 3433 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3490

Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
              ++ ++ + +   V+  QSL  LS+ + +     + +F++        W+  +    + 
Sbjct: 3491 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3543

Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
            + + L+Q L  +    E++++++N WL    ++L  L            Q+ E  +  + 
Sbjct: 3544 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3602

Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
            +LL  Q+++  L      L+ LKQ+        V +++D    I   ++  + + T V +
Sbjct: 3603 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655

Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
             L+ ++Q   +    +++L   ++ + +     + +   V+   E  + Q+   + L+ E
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3711

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
            A++++   + L EV   L  L P  A E +E+     ++R+  V+  I  ++++  + + 
Sbjct: 3712 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3771

Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
              + +  A     + + + E K   L +I +             QD    Q  VQKT   
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3819

Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
              L++  ++D L +    S H ++     S +    ++K L      ++ +     +  +
Sbjct: 3820 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3873

Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
            +LE  + L+    E  + L     E   S ++ + A   +   +    E   +L      
Sbjct: 3874 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3932

Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
             K  +  MN+     T   L   S  +G  + EK++     + Q+ E +       +EA+
Sbjct: 3933 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3987

Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
                    K+D +  SL  ++E+ +    + AEV  I + I++    S   + LQ L  T
Sbjct: 3988 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4047

Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
             ++ R E +   S  TD+  +A    +  +  +D +V  W++  T VE            
Sbjct: 4048 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4102

Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
              +F  D   L+  +K  + F           S+ + +    E   +EI   +      +
Sbjct: 4103 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4162

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
             L  G +L+       K  V + I +L  +W  +     + I + +  ++   Q +  ++
Sbjct: 4163 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4220

Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
             +   + +   +     P +  DL   K+ I+EL+Q  +   Q   E++ +  +A+L   
Sbjct: 4221 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4279

Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
             + E  D   +++ +  L   W+ L  R+  R+ ++E  L     F     EL AWL   
Sbjct: 4280 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4339

Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
            E  + +   +  +     IE  +   ++   L  ++ ++ + + G+ LI++S    A+ +
Sbjct: 4340 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4399

Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
             +KL  +N RWQ++ +    R ++L       +     + +L+ WL   E  L  SKP+ 
Sbjct: 4400 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4458

Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
                    + +   EQ ++  ++     A  E+  ++          C    E + I Q 
Sbjct: 4459 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4511

Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
              +L  +W ++     ER+ K+EE   L  +F +    F +WL  AE+T    +   ++ 
Sbjct: 4512 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4571

Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
             +   ++   + F  +++    Q+  ++K    L   ++      +K ++     RW+ +
Sbjct: 4572 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4631

Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
             +R+    R L     + ++F      ++ WL E +  L + +E  ++ D    ++ Q  
Sbjct: 4632 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4691

Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
             FQ+ +    +  D     G  L +K+   D  L ++D L EL      + G+
Sbjct: 4692 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4744



 Score =  160 bits (404), Expect = 5e-38
 Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)

Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
            LT  S    LS G T+ L   +  A T     G+  +    + P+ SL+   KL +I++ 
Sbjct: 559  LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 616

Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
            +L  K S++   L E +I       L   + E++ Q +     SDL + + S L++H   
Sbjct: 617  LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 670

Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
                  KN +      + +LKE  + SE + +   KL        LE + +K+       
Sbjct: 671  ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 720

Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
            ++ ++HL   H    +S    +   L + E   +  A +  +    + R +D H  L + 
Sbjct: 721  RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 776

Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
            L  +EE  K ++E  E+         L  +A  A  + Q+  + QL   ++++      +
Sbjct: 777  LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 836

Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
             E      EAT  +   +  +++    +    +   ED  Q   +   +++ +   I   
Sbjct: 837  FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 896

Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
                ++++ L       PL               E  I K  E +L      A+ + I  
Sbjct: 897  MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 956

Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
                +  P V        K   D++N    Q+ N L L   + SH     +    YL ++
Sbjct: 957  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 1014

Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
             D +R   +   K    G   +H       Q + ++ FL+ +Q        D+T L KE+
Sbjct: 1015 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1070

Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
                 Y  E  K+    E+                L +++  + L++Q++  ++  D H 
Sbjct: 1071 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1130

Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
                + E +  +  +  L     T+ N  +EF S +        +  +L  + +  N++ 
Sbjct: 1131 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1190

Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
                T    L     V +NT +    +   + K  +      E  + + K  +E  + S 
Sbjct: 1191 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1243

Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
            LK  RS   EK+  F     E Q    + +   ++     L+ DW   K D  VE   + 
Sbjct: 1244 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1303

Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
             + ++ +        +S+K   D    +++   Q       ++  Q E  + L TQL  +
Sbjct: 1304 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1363

Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
            K  +  +E       EC    E  +       L  + Y A  +D+  ++ +  ++ + S 
Sbjct: 1364 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1422

Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
              ++++F +              Y+     S+K L  +++SL+    + V    +++K++
Sbjct: 1423 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1482

Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
            ++I K         K      KI  E +S     + + L   Q+   +HG +  +++ + 
Sbjct: 1483 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1541

Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
            +  +QV    E     F+  + ++Q+++ S  ++ +++ +  R +  +E+      +   
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601

Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
            T+ +   H  + + G   +++K+   ++E+                KN E   N LK+  
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1658

Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
            E L                   E L+L+AE   K+ D  +   +KE    + A   L E 
Sbjct: 1659 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1718

Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
               I  L D   ++     +    H  ++ +            ++ EE +     L T  
Sbjct: 1719 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1778

Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
               +  T E+L  QYQ +             V+ +TQ +Q L   LE++  + +   K +
Sbjct: 1779 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1835

Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
            L     E  +      A +E ++K  H    + Q+EL++ D+  +     L    +EL  
Sbjct: 1836 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1891

Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
             E     D +  L  +  R + F ++    + HK    R      + + E A S  + + 
Sbjct: 1892 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1945

Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
              +     ++ V+ ++ +  DR  ++  KC +L    LK + D      D S   L  LQ
Sbjct: 1946 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 2004

Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
                   K L E I    K L    EE    Q  +S  +    ++KK  EV+L A  S  
Sbjct: 2005 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2062

Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
                    +L  + +  K L D+I+ +  +     +   EK  + +  +    D L ++L
Sbjct: 2063 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2113

Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
              M  +E S KE     L+    QD +  ++ +   I  +      +N ++K      D 
Sbjct: 2114 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2173

Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
              A   Q   +  S +   A  K +E   ++  +++TK+  FE+L  +L T ++ +T  L
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2232

Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
             +          L++Y +E+ +  +E    LE +  ++      G P +   + L K   
Sbjct: 2233 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2291

Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
            L      ++D + EK   ++S + +L         L+  ++E   K   ++ +F A++  
Sbjct: 2292 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2351

Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
              + LE+ K   K++E       +++ V    +S     S   +  +A+  ++   A+++
Sbjct: 2352 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2406

Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
                +T  E     + L  ++   T      E+ G+ L   ++ L  K   L +A +E  
Sbjct: 2407 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2466

Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
                W +++ +   +W+      + EA+     Q +  E    +     +EL + L  L 
Sbjct: 2467 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2526

Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
            +   +                K Q L  L + R + ++    +    +TV A  ++    
Sbjct: 2527 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2586

Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
            KE    +L  +  +  ++ T+ Q+     +E    K  ++Q T + Q +  +   + S +
Sbjct: 2587 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2646

Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
                E+L ++ +K       + +  R  + +   +   + +S +      L D+D K+S+
Sbjct: 2647 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2704

Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
             +  S+   AM +++E        +++ +QQ+ K I+ AQ + + +   +   + K  EL
Sbjct: 2705 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2759

Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
              +++ I      VEQ      + + +      Q+QQ+S+  +     +  + NK+   +
Sbjct: 2760 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2819

Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
             K++    L+K                E  I    +LL      +       L T+  + 
Sbjct: 2820 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2879

Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
             T               ++ AL+  EQ   L   +     +LE++    +  E   SI +
Sbjct: 2880 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2939

Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
            L +    + Q   ++E L         V  I+ EV     KS+ ++V  +   L SK+  
Sbjct: 2940 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 2999

Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
             +   ++  +  EV  E+ R ++          ++         L + QT  K L   + 
Sbjct: 3000 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3059

Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  +L QD+ +              +E + QE + L + V ++ +  + +++ +   
Sbjct: 3060 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3119

Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
             N     FS      D+ D +  +  + E ++KQ   I +  ++ E L+           
Sbjct: 3120 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3179

Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
              L  E+      G++RD L A++ +   + +R A  R+    G++  L     +++E S
Sbjct: 3180 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3237

Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
            +      +KAE   +S   +      ME +       TI Q+          +M ++   
Sbjct: 3238 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3272

Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
            + +   QG +  +         +  +  +T  +E D  D +     L  +V +   +  E
Sbjct: 3273 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3332

Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
             L  C              V   EL   Q   + E + + A +Q Q L Q+L+  +    
Sbjct: 3333 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3392

Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
            E+      K+A   E   K + L          EAL  K +T    LE + ++ Q+ H  
Sbjct: 3393 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3450

Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
                            E L+P+N  L+ +E  +        Q    ++Q+ + K +E  D
Sbjct: 3451 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3493

Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
             I             + +H +       +    SS E+ D+  S L       D  Q  +
Sbjct: 3494 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3534

Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
             E+  K       L +   +  +     V + N+              L ++  + S L 
Sbjct: 3535 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3580

Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
             Q+  TE     L K+  EL +     L    +V++ L       +  +G +V      L
Sbjct: 3581 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3636

Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
            E +K  Y  ++    D+ K +    +    L    + L   L+  +   +     +  G 
Sbjct: 3637 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3696

Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
            + +++ Q   K L  +  K+  +L  SLNE+S   +     +A       E  E  VA  
Sbjct: 3697 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3746

Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
             ++ ER  L    + Q+V +++  +       +A   ELS  ++TE+++  +  G + L 
Sbjct: 3747 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3803

Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
            +            QT +++ +Q     +I  HK     LV +   ++ A S +   S+ +
Sbjct: 3804 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3852

Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
              +       T  +I  E+  Q       + Q WE ++E +  L  + + +IS LP+ +L
Sbjct: 3853 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3911

Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
              ET  +  E    ++Q++  I      + +    G QL+      EL  G+   ++E++
Sbjct: 3912 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3962

Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
            ++   L  +I  ++ +    L   +S +    D++ + LES +  +   + Q  ++S ++
Sbjct: 3963 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 4021

Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
            + I+  I+     S ++++   L   +   G +++         + A   Q +      +
Sbjct: 4022 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4075

Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
             Q+  I E +H L  E+      + E+    W +++    + +D+      +  P    S
Sbjct: 4076 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4135

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
             VK   +  +  R E+D  Q  +D V N     ++ C    K   +    + + E+N  W
Sbjct: 4136 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4191

Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              ++     +I  LE+ +++  + ++ +Q + +W++    +L ++    + +   K    
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4247

Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
             Q IE     KS+A  + +     L   A  LL+      D         EL     S+ 
Sbjct: 4248 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4305

Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
             ++   +  ++  L     +    DE+          +   KPV    + +  ++     
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4365

Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
            LQ++  + + + E + +    L +      A  ++ K +  ++RW  V +    + Q+  
Sbjct: 4366 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4425

Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
              L+  K +   HGE    L+Q   + +   LA+  + G      E L   ++     + 
Sbjct: 4426 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4481

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
              +  K    +   +L R P+ AE++    +   +++L            +R   LE+ L
Sbjct: 4482 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4537

Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
             + A EF   L  F ++  + E    +       LD +  Q  E+   F N V +   Q 
Sbjct: 4538 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4595

Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
             +++    HL   S K  +  V +K L  ++  +W +     +ER   L       K  +
Sbjct: 4596 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4653

Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
              E W +L+E +EE+ K     +++AN   ++  Q   +K  +  +    ++ D+     
Sbjct: 4654 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711

Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
              L + T + ++  +     S+L D+W        +R+  ++  +     FT +++ L  
Sbjct: 4712 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4771

Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
            +L      L+     E   ++    L+  L +    FQ+   +RT+    L+   + L+ 
Sbjct: 4772 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4826

Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
                    V  ++ +L   W+ +       + +L   ++Q   F S V    +   +  E
Sbjct: 4827 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4885

Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
               R   +    ED L  L   +   KE +K+LE+  A     L +  TM   +      
Sbjct: 4886 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4938

Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
            + +  +K  I  +  ++E++       +Q +   L   +   E  + L AWL   E  + 
Sbjct: 4939 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 4998

Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
                  I + IE++ K  + E   F E ++  KQ     +  + K RAA+
Sbjct: 4999 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5046



 Score =  155 bits (393), Expect = 1e-36
 Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)

Query: 616  ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
            ++L +   E  +L E     VE + ++    S+ISK L+   K  +   SK ++      
Sbjct: 1452 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1511

Query: 669  ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
                        + L + K      D   N L K+ K   E     FS  +        +
Sbjct: 1512 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1571

Query: 714  QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
             ++K  EK   E + E+  +L+   D+      +LIG  E +       ++     +  E
Sbjct: 1572 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1630

Query: 768  ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
            E  K +        E++  +E+ L+ + + +S ++         ++ K+ EAK K +   
Sbjct: 1631 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1684

Query: 828  VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
            +K   + K L  V        +  +    ++EES+ ++E+ +     +    E  G   +
Sbjct: 1685 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1741

Query: 880  KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
            KHK+ +  + T       K+     +E+  N+ E D+   +     ++  +++ +  +  
Sbjct: 1742 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1801

Query: 935  LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
              + Q +  I   + +  +L+ + Q ++ E+K   +   K L   +E   +E     +L 
Sbjct: 1802 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1861

Query: 994  HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
            H ++      EEL        E +  L+  EQ++E L   A +I+  +       S +E 
Sbjct: 1862 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1915

Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
             I         T S NR  +       +K D       A    ++  L       +    
Sbjct: 1916 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1973

Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
                   ++  L+++Y  Y D    L   LQ  +   +   S         LQ +L + +
Sbjct: 1974 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2033

Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
             ++ +  ++    E +    E  +          NDI+K       D +  R  +L  ++
Sbjct: 2034 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2088

Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
            N R E L+  L   L V+              S L     +PL+  A+Q       D I 
Sbjct: 2089 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2141

Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
            +++   QD   +Q  I N + E     ++   P    ++Q  +     +F   +H+    
Sbjct: 2142 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2200

Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
                      V+  E+  + L+ FL +    L    +  + VT+LS    +   E     
Sbjct: 2201 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2260

Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
            K+ E    L+K+ + H    DK L +     L   FK+ E      +   TSC+  LDAF
Sbjct: 2261 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2320

Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
             + +     +   +E T++  +++   F   +L K+++D +    K  LK P +  V + 
Sbjct: 2321 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2377

Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
              SL  L   +    +    ++             N+   + +    ++ +   +    +
Sbjct: 2378 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2437

Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
            E+   L+ + + +    L  L++ Q   S +   +QK     +         + +    +
Sbjct: 2438 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2497

Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
            +E  K    E  + V+K+ ++   L   L +     E P  K+    +D +W ++N+ T 
Sbjct: 2498 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2557

Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
            D  + L  +     +   ++  + +W  EK L    L  L+  D   L  + Q  +    
Sbjct: 2558 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2616

Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
            EF+ R  + + L  + +  L     + S+   ++     +T + +  +L+G  ++  + +
Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2674

Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
            DQA  +    +SLL++LS          S SL + T                +EIQQ+  
Sbjct: 2675 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2734

Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
            Q K +  L E+    +  E   +EL +Q E +   F   +   ++H   L          
Sbjct: 2735 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2794

Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
                ++F  W    K    +    S     +E  ++   DF  TL  ++   ++  +  +
Sbjct: 2795 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2854

Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
            ++      +    L   L   +   +      + R  +L++SL++ L+ ++    L  W+
Sbjct: 2855 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2914

Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
                N  E+ K   +P  GE +    ++L ++ +Q F  V  LNN+           KE 
Sbjct: 2915 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2974

Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
               E + +I +   + ++  +            ++  E+ +E K                
Sbjct: 2975 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3034

Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
                       +L T+ +S   L H V    K + + L+V          E    K    
Sbjct: 3035 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3083

Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
            +LL+ E  A+  + + Q    +   ++  L  I +  +    + S +    ++L      
Sbjct: 3084 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3143

Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
              + E   + KE ++  L +L+       AL           K+     + + DL  + +
Sbjct: 3144 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3196

Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
            +L++   Q N LL+  +  +  E+    IK L E  S L++    +Q  +    EH+  Q
Sbjct: 3197 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3250

Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
              V     T++     F  F  + +      E LQ  Q+  N L            L +S
Sbjct: 3251 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3295

Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
              ++TS+ G +   DD+ +  +   K +  R A  ++ +  C      L S+L     TE
Sbjct: 3296 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3355

Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
            +     L   +K  +++   V+   QE   +++L +D     E+ K    ++A + +   
Sbjct: 3356 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410

Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
             + +  Q S+ ++  E  +N  E +N+ LE  +++           NE L  IEK     
Sbjct: 3411 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3470

Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
            E        LE+    +K     ++ HN        IG S + L +     +   K   S
Sbjct: 3471 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3530

Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
            Q   + + QE   +    ++  L + +      ++ + +L+++   ++ +  +  S   L
Sbjct: 3531 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3589

Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
               W+  S   V   D  L +  + Q L +G E ++Q        IQ K       Y + 
Sbjct: 3590 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3646

Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
            T L   V  T     +Q   L  RL S  E            +++   +   VLKG    
Sbjct: 3647 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3699

Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
            QA+++ K +  E K  K L D +N +         W   E L  + AE+    ++    I
Sbjct: 3700 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3759

Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
              K++E                  + W      +L     I L  D   +Q++  K    
Sbjct: 3760 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3819

Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
             IL  +  ++ L +     + + +  E   +   L+ +   Y  +   +++R  QLE   
Sbjct: 3820 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3879

Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
               + F+    +    + E+++ II ++   A E E      TL   Q+E +++   I+ 
Sbjct: 3880 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3932

Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
            H   +  + +      EL+  E   ++++        ++I+  ++     ++  I    Q
Sbjct: 3933 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 3992

Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
            FH+K   + E   S++R    L Q  +  +  E+  +K++++  K   + + KL+ +++ 
Sbjct: 3993 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4047

Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
            +            G + D S      +LDQ+        T V E+E +L + ++  + F 
Sbjct: 4048 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4107

Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
             +H      +   +    DL+   +   V+K    + E+ R     L + ++    L  E
Sbjct: 4108 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4167

Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
            +I    E    D    +K I ++       D L K  ++ + +L          QD L+ 
Sbjct: 4168 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4221

Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
                ++    +L     I  +++ ++ + +       EA+Q+Q+  E  + +A   ++K 
Sbjct: 4222 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4281

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
             EE  S+   V+  L E + +   L   I  R + L  A   L +++ A+   +  +T  
Sbjct: 4282 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4339

Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
            E ++   +  VG   +++E+ L K   L++ V   Q   E +          S+ E    
Sbjct: 4340 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4398

Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
            LQ  L+ L  +   + E  + ++ + +  L   K +    ED+   L+  E  L   + +
Sbjct: 4399 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4458

Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
              LP + +E L   +E   A  +   + K  + K +Q+L     RC ++    + + ++ 
Sbjct: 4459 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4514

Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
            L EKW S+     E +   EE                 W   +E+      R ++ILD +
Sbjct: 4515 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4574

Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
              ++ E  +   +  +  E++ EL      L    Q  + V  + LL+++  +  + +Q 
Sbjct: 4575 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4634

Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
            + E   +++           A+ ++    E   K L    ++  + + ++T++ +   F 
Sbjct: 4635 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4694

Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
            K + A  + +  T  + +++  +     D+ +  +   EL              Q+ L++
Sbjct: 4695 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4754

Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
              L      + L+     +Y + P   E Q      +    L D  +    E+ K + S 
Sbjct: 4755 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4814

Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
             A++R   E+  G  +    V+  +Q+ S   E    +       L+    +  E  S V
Sbjct: 4815 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4874

Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
              ++E         +  G   +  D L     Q+++  ++ E + ++LNKAT   +    
Sbjct: 4875 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4934

Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
              + D + + + WI      +      + L     H   +  AL     K  LL ++   
Sbjct: 4935 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 4989

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
            L+       TD+  + I +   +V AL    Q  ME + + Q   D V
Sbjct: 4990 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036



 Score =  155 bits (392), Expect = 1e-36
 Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)

Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
            +L  L+S+  ++L +  ++  FS     +++       Q  Q+ +++ +   +E   Y +
Sbjct: 1037 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1096

Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
             ++++     N      +  D+ + QI    +   L E   R++ Q+   K++  L    
Sbjct: 1097 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1148

Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
                        KDD+ ++  +C++   +   +S+   +   LN +L++           
Sbjct: 1149 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1196

Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
            +   + +  + V ++TQ + A+ KL E     +++ +    + +  ++  +  ++  DE+
Sbjct: 1197 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1254

Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
            +       +ELQ      D M +  +  +++  +     K+ A + +E+ + ++      
Sbjct: 1255 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1305

Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
                        +DN L+ L  + K+ +          +++  VE++ + +   +E+   
Sbjct: 1306 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1351

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
                  T L++ K  ++ IE ++  +   +   E  S  V D +      + +++SQ K 
Sbjct: 1352 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1411

Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
                   +     I +++      Y    TLM +      D+   L+++++ L+   K  
Sbjct: 1412 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1471

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
             E+A          +LQ      S     AE   K  +  K+K + E+     ++  E L
Sbjct: 1472 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1521

Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
            + + L       K   + RN++++ +         L  S  LL  + L Q+++ + + D 
Sbjct: 1522 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1573

Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
            +   ++ V    +E K+K+      LT  E   + +    +     + + K   + ++L+
Sbjct: 1574 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1633

Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
              ++  +   A + K          + + QE + LI    E    EA++K   + L+A Q
Sbjct: 1634 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1689

Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
             + +E+D  ++T ++E T         E++    QL+  K +   +  ++ N   + E  
Sbjct: 1690 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1739

Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
                +Q  E+     +E D           N  LL  +V+  V     NL  +   +K  
Sbjct: 1740 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1799

Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
              +++   +       +       Q Q    E++++L++ +K+L    E      AL   
Sbjct: 1800 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1854

Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
             + + L      E+     D +     L  Q   Q +E  +   D+I   + KL   K+F
Sbjct: 1855 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1912

Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
             +           + + + D  Y  +  N VLE +         ++D      +++  L 
Sbjct: 1913 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1962

Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
            H  ++ +S   +  ++   +K + ++  + E     + A + + +A TA +   E  + +
Sbjct: 1963 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 2021

Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
              +++ +L E + LQ Q+++       +     VL DA  +L   K  + + ++ I    
Sbjct: 2022 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2077

Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
                     VG  E+  +    + E+L+ T+     +QD L E L  + + E+ L+ Q  
Sbjct: 2078 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128

Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
                   LQ+++SKN  +++    +++      E  K + +  +    ++L      L  
Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188

Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
              S     ++E L ++E+ K  V    +  E   KL+  L       TE D  G  + ++
Sbjct: 2189 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2245

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
               + E     LE  K  E+    LK+     S  +  + A++L+   NL ++  E+  T
Sbjct: 2246 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2302

Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
                KEA T+          CQ  E ++  Q+L+  L   I+            + VP  
Sbjct: 2303 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2341

Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
            Q     ++   K L+  +K +E    +  E        I+L N     TT  + +A    
Sbjct: 2342 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2400

Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
                   +     +E+F        KG  + +  M  +   Y ++  ++    AE+ +++
Sbjct: 2401 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2455

Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
             + +KA E+        +K++    K   + A     E +   +   +    +  +N+ K
Sbjct: 2456 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2514

Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
             QE++ K+ + L+          W   L E+DS+ Q++ +   D  Q  E   N +  FQ
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2574

Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
                Q +Q     E   S              Q  +  + ++E++      E        
Sbjct: 2575 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2634

Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
            +L+ P +  SLR                    LS     +  A+  S Q  +LL S+   
Sbjct: 2635 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
            L DL     +     +  +  NQ     QK+ + + Q        Q + +D+ A+  E  
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2754

Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
               +   +++ IL S +  +   E H++H +    +    ++   +  ++    +  Q  
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2814

Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
              P+            + +LE++ ++  +  K +  Q++ +++ I   + +L        
Sbjct: 2815 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2857

Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
            L+    ++A    +L  ++   +   KQ+    N+ KE L   +  K  V  L   + + 
Sbjct: 2858 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2917

Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
            Q  +E  +     +E E  +A+  + ++++           N   S+  +  +++EV   
Sbjct: 2918 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2977

Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
              KS     D   E+         ++ +  K+ +E   S  S   +Q A  ++   D+  
Sbjct: 2978 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3035

Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
            +Q  +   L   Q  + SL+  + +      +  D  +++SD++G  +   +VE    E 
Sbjct: 3036 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3095

Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
            + +      + + LE  LQ      N   E  +  A+               + L++Q  
Sbjct: 3096 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3155

Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
              +A L ++E  +A      +TCK     ++   D    + + EALS +    L   +  
Sbjct: 3156 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3215

Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
             E+V+     L+E +S+ +  +IL + +E EH+E+  PV + E E+I     Q +  K F
Sbjct: 3216 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3270

Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
            Q++++  L+  +Q  +++    I+  AK    Q  +HD D       T  +  A   A  
Sbjct: 3271 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3330

Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
             E         D  +S+LS        W     EL +  K P                L 
Sbjct: 3331 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3382

Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
            +L++ + ST                    + IL  +++ + R+     + +T   QLE +
Sbjct: 3383 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3442

Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
               A           E    ++K+L       +Q  S +EE +   +   +D      H 
Sbjct: 3443 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3500

Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
                     L+ A+S   G  LK ++   E+ +++    D  QV     Q  +  RS+ L
Sbjct: 3501 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3548

Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
            +  L   + +  +   L + L +    L + S+ + S + + +Q  +      ++   + 
Sbjct: 3549 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3608

Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
             V +    G  L L      EV  ++D L++    ++ARY +++  S  V ++ + AL  
Sbjct: 3609 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3663

Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
               L    E     L K+  E L++   +  K + A QAQ+         +N+K     L
Sbjct: 3664 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3722

Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
              V+  LL      +++P         W  +    K++ E + +  +   ++ QK EE D
Sbjct: 3723 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3767

Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
               A++ +  +   +    +S + ETE++L+         ++ S   Q+++    +  R 
Sbjct: 3768 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3824

Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
               +++    G +++ + S  E +    KL+      +    +N +   +L R Q+L+  
Sbjct: 3825 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3884

Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
               +    ++L  WL  +Q  ++     +L    + +T+R       +  + + E     
Sbjct: 3885 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3937

Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
              +   G QLL L   +  +++      +  ++ +   +      L +   +       I
Sbjct: 3938 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 3997

Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
             +++  +  +  +     S+ +     ++K  + ++K   ++M+  Q + + + Q   ++
Sbjct: 3998 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
                  +  D+ +K  +     + L +M   W  +H ++  +   L  ++E   +     
Sbjct: 4056 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4110

Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
              L   ++  ++ ++ L+ P    SV K     Q+    +  +   L E     + L S 
Sbjct: 4111 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4167

Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
             +    +         IDEL     S+      ++++L+ +MQ+ +Q       ++D V+
Sbjct: 4168 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4227

Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
            +   +    +    P+   LET++ Q+E L+  + EA   +   E+L      L  K   
Sbjct: 4228 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4283

Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
             S    +++        W  + + I ++  K +  L     + +A  E  A L   E   
Sbjct: 4284 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4343

Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
             +   +   G+  A  +  A   +  LQ+DV   Q T EA  +  + L       E+S  
Sbjct: 4344 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4398

Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
              L   L  L QR   + +    +  + +  L Q K F   +E L+  +   E +L    
Sbjct: 4399 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4456

Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
                L +  KE  +  +    A  A+    + L     ++  + P S      + + N+ 
Sbjct: 4457 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4516

Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
             +W        ER ++L+  + L  +F    + +I  L + E+ L V    S P L+   
Sbjct: 4517 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4573

Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
              +++ E +V  N+   +S+  Q ++L  T T ++  ++ + +     L      RW+  
Sbjct: 4574 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4631

Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
            VQ + +R   +D   ++ + F  +   L  +L ++   L S ++        +T+   H+
Sbjct: 4632 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4691

Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
               K +    + +    T   G  L   T L      +   +S+L+D W  +  +  E  
Sbjct: 4692 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749

Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
             + +  +    Q    ++ L   L  ++ Q  +  P +H D+     LI   K  ++ L 
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4808

Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
              T +++ L+    +L      +D   +K Q++ L  +WE +C     ++  +E  L   
Sbjct: 4809 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4867

Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
              F+     L  WL + E       VL   + ++  +I++  K+ M+++        +  
Sbjct: 4868 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4926

Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
             MGD ++   +      I   +  I  R++ +        ++L    A +    + +  L
Sbjct: 4927 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4986

Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
              WL   E+ L+   K V+    + +E++  +AE Q    ++ +    V+ V        
Sbjct: 4987 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5044

Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
             D  +                           ++T+ ++       L  +W+ +  +++E
Sbjct: 5045 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5104

Query: 6127 RRMKIEE 6133
            RR K+ +
Sbjct: 5105 RRRKLND 5111



 Score =  146 bits (369), Expect = 6e-34
 Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)

Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
            P+  +AM P++ F++     P  +E++     +E+ Y   +    E +   + ++  H+L
Sbjct: 956  PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 1011

Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
             N   RI  S+ +S +       Q  L++LQ    +     +E ++ S     +LE  VN
Sbjct: 1012 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1071

Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
              K+ +    ++ LK  ERE Q              +  R+E+ E  L  ++  P+E+  
Sbjct: 1072 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1127

Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
            L         H+     F + + +++ + L  ++D +     I N+ EE  +        
Sbjct: 1128 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1172

Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
              L +  N++L+   Q   M+       D LK +   L + + A+   +   T L   + 
Sbjct: 1173 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1229

Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
             +A +N +     T+K    E+       H ++D   KAK +     K  K  D+ F   
Sbjct: 1230 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1289

Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
            +   D   E   N+      +L +  G G   ++  +    L+  I +     + IQ+ Q
Sbjct: 1290 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1349

Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
             + SK      T+    +++K L+  ++    + +E +++ ++ + ++   KD   +T+ 
Sbjct: 1350 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1400

Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
             +     ++    K+ V     Q    L +++++ + ++  T L+      +  Q     
Sbjct: 1401 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1450

Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
             ++LK+   E + ++EE  EH+E   ++ +   N+   L   +   +PPF K+       
Sbjct: 1451 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1504

Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
                +E+     E L  AL            I  +  K   KM     T+E+R  L++++
Sbjct: 1505 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1547

Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
            + + E     FS  + ++Q    S ++ +E +++             I + +   +  L 
Sbjct: 1548 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1607

Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
            G      +   T EL+    +  +  K   G  ++L + +  +++   E   KL +  + 
Sbjct: 1608 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1667

Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
            +++QK    L E +I C  L  +  + KK+ + V      +++       +L   + K  
Sbjct: 1668 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1723

Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
            N  DW SN+  + +                F+  + K ++ ++ +   + L         
Sbjct: 1724 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1783

Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
             T E  N + ++V    + ++   +  +      +++    GQ    E+ E + Q   KE
Sbjct: 1784 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1842

Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
            L+                  SLQ+ L   D D+     WL   E++ + +E   +     
Sbjct: 1843 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1902

Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
               L R++   E V      L+    +    +    +C                      
Sbjct: 1903 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1962

Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
               DR+++L  + + +    K L  + Q + D                       +A D 
Sbjct: 1963 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2022

Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
             +  ++++E+  +      +    E+++K  E++L     DAR   +  + +      +Q
Sbjct: 2023 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2071

Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
            KTL DI  ++++   L+ +     EKL +   + L  ++ L  ML     +E   K++  
Sbjct: 2072 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128

Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
              L        A   I  K +   QD+       +S  N + E  K    + +P      
Sbjct: 2129 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2174

Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
               SL  +++D          +H      + +L T +   +N S++  +F +     +  
Sbjct: 2175 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2234

Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
                   V E  Q +QE  +        L+ + +L K +  +     + ++ +   +L  
Sbjct: 2235 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2294

Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
            K K++E+ +   K+ +  C         ++KS +S  K+    +P  +      D+ +S 
Sbjct: 2295 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2354

Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
            +++   +KL+E W     EI K                    A+    S    LN + + 
Sbjct: 2355 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2411

Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
             NTE+          ++ + ++ +   +L  +L+++  E   KL    +A++ +   ++ 
Sbjct: 2412 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2471

Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
             + +NKT T         +         +A+ T +++NK               + E+ +
Sbjct: 2472 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2508

Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
            K  +   + LK    D +T L +         + K  L  +  KW+ L+    D  +KL 
Sbjct: 2509 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2564

Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
            ES     +       Q ++ +  Q +VE +   +++  +      L  Q+Q +Q+ L+  
Sbjct: 2565 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2618

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
              R             Q T  G  +L    E           +  +++ +  + ++W++L
Sbjct: 2619 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2663

Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
                 +  + I +  +++   +++L +      +L  +L+ S+ +   PD +  Q+   +
Sbjct: 2664 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2723

Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
                 I   ++ +   ++L E++   V     Y  ++L+  LE +   ++ +  K+    
Sbjct: 2724 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2781

Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
            Q L+        F  + R FQ  +   +            E + K H ++     LE+  
Sbjct: 2782 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2829

Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
            K+ ++    ++  +H+ E T     N+  +    E+  L+ QL  +K   +   + ++  
Sbjct: 2830 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2889

Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
             N+++  ++   ++ E+   L    D  Q N  E+    +  +G              ++
Sbjct: 2890 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2949

Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
             + + + L      +L V ++ K            ++D +  Q+  K+  LE   ++   
Sbjct: 2950 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 3009

Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
            F+E  +  K Q   +K   +D+     ++       +  ++++ + Q L  +++ AK L 
Sbjct: 3010 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3068

Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
             +++ + +++K   D      +LQ++  A+E+  L + +      L  K     + Q+ +
Sbjct: 3069 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3123

Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
                    +   +L     +  + + +Q +K+  +AF +++ A M S        K    
Sbjct: 3124 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3183

Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
                + D+    R+ E L  Q N  +D               L + Y  L  +   + +A
Sbjct: 3184 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3243

Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
             E   S      P  ++     + L M  + ++EE+E      QD+     G+I S    
Sbjct: 3244 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3299

Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
               Q    +L   N+  K   K     A +  E      + ++ + + LS M    E V 
Sbjct: 3300 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3359

Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
             Q   S    ++    ++++ K L   L   K  +  +++    +       D + +LK 
Sbjct: 3360 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3417

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
            +S L  +W +LL  A+      E +    +   E +E     L  +++ L   E   T+ 
Sbjct: 3418 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3477

Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
            +   E++++   L D +  + +++ +      + + +   + +  E    V++   F ++
Sbjct: 3478 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3532

Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
              +     ++ +K     EL+Q  +     F ++ + L N+  +       ++ QD+  +
Sbjct: 3533 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3587

Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
               +Q  EL+ + +   L  +N+ + L      +      E   I+ ++E  +   +DI 
Sbjct: 3588 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3646

Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
             K+S +V K+   +  + R++    EE+   L  VE  L        K +   +AQ   K
Sbjct: 3647 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3706

Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
            ++  E     + L+ L+     ++E  P +A+E ++ ++    ++Y+ VS     +  ++
Sbjct: 3707 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3766

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            + A ++ +++     +  +WI  T   L +  D      L    ++ Q+ ++ +     L
Sbjct: 3767 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3822

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
             H   +           D+L +S  ++    +  + Q + + L ++ +  D +  I SE 
Sbjct: 3823 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3871

Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
                                    +   +  +S++    L  E      EEH +  E+I 
Sbjct: 3872 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3931

Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
            E   +I  M KT  +++        P  G      +   + L   IK  E+V +++   L
Sbjct: 3932 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3983

Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
               I Q+ ++ ++I+ + +         SLE +  ++  + P +  E+E++++QI     
Sbjct: 3984 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4029

Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
              +++ VD++  +  L++ LKQ  E
Sbjct: 4030 ENKNVSVDME-KLQPLYETLKQRGE 4053



 Score = 88.6 bits (218), Expect = 2e-16
 Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)

Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
            ++LS   G+ +QE++   + L              L+  I ++ +    I  +   + +I
Sbjct: 3948 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4007

Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
              +    P++ A        +   K   + ++K+   YE  K+  +EM A S    KD  
Sbjct: 4008 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4067

Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
             K V  +    V +WEN   LV E   +   V+EL +++  +  S++ T+   ++ +  L
Sbjct: 4068 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4127

Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
            +   +    +K++    E ++EE +   E +D +  +   L   +      ++P  +K  
Sbjct: 4128 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4184

Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
            + +   W  +N+  +D  + L  A+    +  +    + +W + A  K+        D E
Sbjct: 4185 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4244

Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
             +K++++  +Q  SE  ++  E++ L   +E+ L+    ES        L +++ +   L
Sbjct: 4245 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4304

Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
                 +  H L G   +  + +  LD+    +  TE LL    P        ++E  +  
Sbjct: 4305 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4364

Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
            +LQ              K    L+E+  G     L  +L  L +++++V +    +K  L
Sbjct: 4365 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4424

Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
                  +K  + + ++   W ++ + +L   K      ET K  EQ    +      E +
Sbjct: 4425 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4482

Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
                K +    + +    PK+    +   +   + + E +E+    R  +LE++L   + 
Sbjct: 4483 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4542

Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
              +  ++   WLT  E+       P           ++ ++F   +   REQ   + +  
Sbjct: 4543 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4602

Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
              LK   F++++++++    L+    R++ ++++L E            + F++    ++
Sbjct: 4603 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4660

Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
             W++E ++SL      + ++ +     KIK  +    E    +    ++      +   L
Sbjct: 4661 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714

Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
             +KT            L+++ ++WD     +    +  E+ LL   ++  + + L   L 
Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4774

Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
             ++ +      +   +      +  +K F K+    TS ++ LK     L+E ++ + S+
Sbjct: 4775 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4834

Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
             +    E+    E++          L+  +R+ + +   V  L   L    +        
Sbjct: 4835 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4894

Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
            P D+ A+   + + +E   +L  +   L K       +LA+       T      II+  
Sbjct: 4895 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4954

Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
             + +    K  + RLAS      AKQE +E  L  +  ++ +   K K  +P   ++  +
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5014

Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
             +       +E T++   V+K+ + ++
Sbjct: 5015 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5041



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)

Query: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            D+W+ I  + +  + K+++ L    Q    + A+  WL + E +L   +      DI  +
Sbjct: 4736 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4793

Query: 6590 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6649
               +   +   K      + V ++  S++E ++    +S+ ++ ++++LS  WE      
Sbjct: 4794 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4853

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6708
             S +  L  +L Q ++FH +   LL WLA A+   R    + D +   R L++  +E M 
Sbjct: 4854 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4912

Query: 6709 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              K+L E++ +++    + +++L   H +     +  + +I  + +++
Sbjct: 4913 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4958



 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)

Query: 6548 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6604
            K+++ +Q   Q    + A+  W+     +L    M+   +D++ ++ +++ L++      
Sbjct: 4204 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4261

Query: 6605 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6662
              +  +  +N  ++  L+  TE  +   +Q  L +L L+W++ +  + + +  L  +L+ 
Sbjct: 4262 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4321

Query: 6663 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6720
               F      LL WL   +     QK    DPKA    L +       L+ +++  Q  V
Sbjct: 4322 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4377

Query: 6721 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6774
            + + +  N L+    GE+    + K+ V+ ++ + + E+  Q    L G    A
Sbjct: 4378 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4431



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 56/276 (20%), Positives = 107/276 (38%), Gaps = 24/276 (8%)

Query: 6504 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 6550
            K G  VLNG     N ++   + GL  I +  +     +E +      +  EL+ KL   
Sbjct: 2399 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2456

Query: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 6610
              LQ+   + SA+  WL+K        +    P+D + ++ +V++ +            V
Sbjct: 2457 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2515

Query: 6611 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
              +     E L+   ++PE+   +  L ++   W+         +  L +S      F  
Sbjct: 2516 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2575

Query: 6669 LSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEIS 6727
            +   L  WL     +     V  P   DP  L   R+++  L +E   R+PQ + L    
Sbjct: 2576 VEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2632

Query: 6728 NSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 6761
              +L +   +  +    +E++  + +K   L  Q+S
Sbjct: 2633 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2668



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)

Query: 585  LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
            L  W T+ E L    +    + K  EI+      L    L H +    +N+AGN L+E S
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4391

Query: 640  NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
                 S++  +L  LN+RW+ ++ KT+         +KQ           L    +    
Sbjct: 4392 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4433

Query: 700  FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
            F  ++     E+  Q +   E+H   ++   G  + AK  E+L   +E+  A EAK    
Sbjct: 4434 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4482

Query: 759  QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
                    EE+ K L+ KG  M       +E  +  DI N+  +E ++ V     + K+ 
Sbjct: 4483 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4527

Query: 818  EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
            E K K++                   L++ ++   S ++  +++ +A+Q L     P  +
Sbjct: 4528 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570

Query: 878  -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
                   I +HK     + S+ + + +  K    LK    +   + ++     V ++WE 
Sbjct: 4571 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4630

Query: 929  LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
            +       VQ+L   +E+G+  D+  K  KQ ++   KL+       K L  E E     
Sbjct: 4631 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4680

Query: 986  EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
            +    QL  H E  + L  +     +     R LK+
Sbjct: 4681 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4716



 Score = 43.9 bits (102), Expect = 0.006
 Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)

Query: 6541 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6600
            Q L +        QQ++ D  A   WL   + E           D+  +E  +K  ++  
Sbjct: 2782 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2836

Query: 6601 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6658
            K   T ++ +    ++  E   L+T+  E   LQ +L  +   W+     V      L++
Sbjct: 2837 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2895

Query: 6659 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6718
            SL +   + +  + L  W+   +N  ++        DP        +L  L+KE+ +   
Sbjct: 2896 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2952

Query: 6719 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6778
             V++L   +NSLL     +  +  +E   +I+ K+  + EQ+      L   +N      
Sbjct: 2953 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 3008

Query: 6779 SFDEV 6783
             F EV
Sbjct: 3009 EFQEV 3013



 Score = 41.6 bits (96), Expect = 0.028
 Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
            W+ ++ + ++ + K++  L    Q    +  +  WL  TE    +L   KP   D + IE
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4357

Query: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
            + + +   +      +++ V +VN +  + +++ +  E++ LQ++L  L+  W+      
Sbjct: 4358 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4417

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
            +  +  L  +L Q + FH   ++L  WL   +      H+   K     L E  +E + +
Sbjct: 4418 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4471

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6755
              E+       +  +E   SL+ KG                +D    +EK   +E KL +
Sbjct: 4472 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4528

Query: 6756 LREQVSQDL 6764
             + ++ + L
Sbjct: 4529 RKTKLEEAL 4537



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 17/259 (6%)

Query: 6554 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6611
            QQ +    A  +W+ +TE +L  L   +   D    +L+V++    EIL+  D    LV 
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3833

Query: 6612 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6671
            S     K        E   ++ +L ++   ++            L ++      F +  +
Sbjct: 3834 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3890

Query: 6672 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
             L  WL   ++    + +  P  +   L + + E  QL + + E +P +D + +    LL
Sbjct: 3891 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3948

Query: 6732 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL-----QGTQ---NPASPLPSFDE- 6782
                GE     +EK    +    Q++E V +  +AL     Q TQ        L S +  
Sbjct: 3949 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4007

Query: 6783 VDSGDQPPATSVPAPRAKQ 6801
            V+   QPP+ S    + K+
Sbjct: 4008 VERLRQPPSISAEVEKIKE 4026



 Score = 37.0 bits (84), Expect = 0.68
 Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)

Query: 6535 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6587
            W +   ++ H++ ++ Q    N +    D   +  WL +   +L  L +    ++    Q
Sbjct: 3533 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3592

Query: 6588 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6647
            + ELRV +   +L+  +  +AL+  + +      QT   E   +Q +L  +   ++    
Sbjct: 3593 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3648

Query: 6648 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6707
                    L Q+L   +  H   + L  WL   +           K +  +  + R +  
Sbjct: 3649 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3706

Query: 6708 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6760
            +L+KE    +  +D L E+S++LL        +G  +   E  E+  ++   + Q  E++
Sbjct: 3707 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3766

Query: 6761 SQDLMALQ 6768
               ++  Q
Sbjct: 3767 DAAILRSQ 3774



 Score = 36.2 bits (82), Expect = 1.2
 Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)

Query: 310  KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
            K+++++L K  +++ Y ++       ME  N + +  L  ++ + D   +    ++L+  
Sbjct: 4247 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4300

Query: 370  WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
            WD L+ +I   + KL  AL         L +  AWL   E L+ E      D  +A+ + 
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4359

Query: 423  ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
                  +Q  +   +S ++      N L+     +E ++L     NKLE + +R  N+LE
Sbjct: 4360 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4415

Query: 476  K 476
            K
Sbjct: 4416 K 4416



 Score = 35.8 bits (81), Expect = 1.5
 Identities = 33/191 (17%), Positives = 88/191 (46%), Gaps = 18/191 (9%)

Query: 6549 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 6605
            + QNL  +++N   +  +  W+ + + +L+  +     SD+  +E  ++  + + +A + 
Sbjct: 623  LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 679

Query: 6606 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQD 6665
            +++ +    +S    +Q  +P       +L +L    E+    + +      + L    +
Sbjct: 680  FESSLKEAKISE---IQMTAPLKLTYAEKLHRL----ESQYAKLLNTSRNQERHLDTLHN 732

Query: 6666 FHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLEKELVERQPQVDMLQ 6724
            F   + N L+WL    N +++  V    ++    +  +++   +L +EL +++  +  +Q
Sbjct: 733  FVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQ 788

Query: 6725 EISNSLLIKGH 6735
            EI+  LL++ H
Sbjct: 789  EIAEQLLLENH 799



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)

Query: 6624 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6683
            +S  +  L+  L  ++  W+     V      L+++L+ C  F    ++LL W+   +  
Sbjct: 3298 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3355

Query: 6684 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6743
               A+   P A+ + +    +E   L++ L +R+  V++++     +       D ++  
Sbjct: 3356 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3415

Query: 6744 EKVHVIEKKLKQLREQVSQDLMALQG 6769
            +++ +++ + + L  +       L+G
Sbjct: 3416 KQLSLLDSRWEALLNKAETRNRQLEG 3441


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  234 bits (596), Expect = 3e-60
 Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)

Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
            +N I + + S     K  LPG  +Q  S++Q       E +QES       + +LE++  
Sbjct: 1023 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1082

Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
            + K    E+  S +                 N +  ++N ED R + +++  PLE D + 
Sbjct: 1083 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1140

Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
             +  ++ E EKL  +LE  K  +  +     E  ++    +          +VL N+   
Sbjct: 1141 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1200

Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
               S+ ++D L    + LK N ++   +++ ++  L   E    A++ DK +++      
Sbjct: 1201 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1249

Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
               +  +K++ + +++++     L+ + +       +M K   E  +          QL 
Sbjct: 1250 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1308

Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
              W+ V  QI  +      + +     +   +DT   L    Q ++   +  +E     S
Sbjct: 1309 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1364

Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
               L T L   K   S      E++MK+   ++ +K  E     +K             +
Sbjct: 1365 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1417

Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
            +Q K    R +M+ +         +L      L   +    +  K   D +   ++  +S
Sbjct: 1418 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1474

Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
            L EE K+ V      +   S+++ TL+D     +    K    S+++  K E+ S     
Sbjct: 1475 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1534

Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
            I+ F                      +QES  L+    + +++ + T  ++K     +  
Sbjct: 1535 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1594

Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
             Q+E +E   GI   L +  N    +   E   + D   +LK  + +   +Q+ +Q +  
Sbjct: 1595 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1652

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
             +   +K    F      L+E  + + Q ++ L+ Q++N+  +K E  NLK        D
Sbjct: 1653 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1706

Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
            ++  TAIK        + Q+ + K   + + L+W  S +D+   +   K K++   I+Q 
Sbjct: 1707 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1761

Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
             T F+E  GK         AI  + +    ++    D    + + N   L+Q+ +K K  
Sbjct: 1762 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1810

Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
             ++II   ++++    + +  ++L  K    L+ EE +KL K ++ + +  E +  E ++
Sbjct: 1811 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1867

Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
            K     + Q++LE       + +  LQQ    L NLE     I  +  +    ++F E V
Sbjct: 1868 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1927

Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
             +    ++ +T    +              + + S+   +V+ KL    D    L +  +
Sbjct: 1928 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1987

Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
            +  N L D  +    Y++A    +  + + EA     +  P  VD  N +  LE     Q
Sbjct: 1988 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2047

Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
             ++ S    ++ L +   ++     S   AK  +Q TL ++V +   + ++   +  + +
Sbjct: 2048 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2107

Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
              L      +   +++   +  +E+ L +    +PL+     + + ++  L  ++   + 
Sbjct: 2108 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2166

Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
             +  + + ++        +    L   +  L  ++       KE     EELK + +   
Sbjct: 2167 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2223

Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
                    + +NL E+L    +TK  A TE         ELS+ + +   ++ E+ +  +
Sbjct: 2224 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2275

Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
            +L +LL +   S   +P     V      ++  ++ ++  ++   +++ KE V +  ++ 
Sbjct: 2276 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2328

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
             +F   + +LK++ ++TT     +      E   +  E+ + + +K  L    I +    
Sbjct: 2329 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2388

Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
             I    + + V  PA+  + V+     L       + +E  +N+ L S        S  Y
Sbjct: 2389 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2448

Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
                  ++ KI E+N  L  ++K  ++ S  ++  Q++ K    W               
Sbjct: 2449 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2508

Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
                     EL    +K+ EL  ++ +++E++P   +A  W   L     ++Q+++Q   
Sbjct: 2509 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568

Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
             R  +L +++  + ++  +    + W+     +++   P   D    L+     VQ+ L+
Sbjct: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2627

Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
            +   +      +    +  LS   E   L   ++E    VT     +   L       D 
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687

Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
             +   ++ +S+ + +S   + L +K     +   H       LE  + MK+ I       
Sbjct: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2740

Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  Q   K + V Q   + L  +   E +  E +  L+ ++K   + +++ EN  Q 
Sbjct: 2741 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2794

Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
            L +  A     + MS D    L   + E  +       L+   E L+ D K  +  L   
Sbjct: 2795 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2853

Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
             H+ ++      + L      E    +   +  K N       +   E +++ES  K+  
Sbjct: 2854 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2913

Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
              E+ E     W  + K   ++EE +                +  +NS+A++    SL  
Sbjct: 2914 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2956

Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
            E      +    N T        E D    +D    L  +V+      TE LH+ K  + 
Sbjct: 2957 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 3012

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
             +                    Q+  E Q         E+  +    L+  K+Q  + D+
Sbjct: 3013 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3044

Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
              +Q  +      L+T + +L+  K Q+ L ++ ++D    ++ ++S+ +    +    L
Sbjct: 3045 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3096

Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
             ++E+I  E    S+Q D ++   LE K      F   I    ++M+ Q+ + D++    
Sbjct: 3097 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3150

Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
                              ++P G++ +  Q     + + +K      +E  +++N     
Sbjct: 3151 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3187

Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
            +  M      T+ +L      LE L ++ + L  +    EE      K+L E +  L + 
Sbjct: 3188 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3246

Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
                  +L+    + E      +  ET+  +L    +   ++   L    + + W G+  
Sbjct: 3247 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3303

Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
                    +T  L    D++    +        R+  L+  L +   +Q+ ++ L   ++
Sbjct: 3304 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3363

Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
             ++  +  Q       + V  Q+Q+       L++ +S V  ++ EGE++        +V
Sbjct: 3364 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423

Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
              L+ +  LDS W  L      R  +L    V   Q    L+ + E +   +++L +   
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483

Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
                     +Q     AL+  I NH     + V+    ++  S++    ++Q++  F   
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3541

Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
            QV  ++I +EKS      LQ  L   + F E+   L   L  +   L  +S+ + + E L
Sbjct: 3542 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3600

Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
             ++ S  + ++ +I  +   + Q L  G +L+   +  E   ++ ++  ++ ++  + K 
Sbjct: 3601 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3660

Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
                   L+  L+     +   ++L  WL+  +  L  ++ Q L   +     +R     
Sbjct: 3661 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3717

Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
              E  KE     +L  ++  + + LL L        L   +A+  +++ ++   +    E
Sbjct: 3718 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3775

Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
            ++    +      +A    +SW+   E +      +      +  +  LQ  K F ME +
Sbjct: 3776 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3833

Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
             +K  I D V      ++ C  E K+  + +  + L           E   Q  R   ++
Sbjct: 3834 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3893

Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
            N+  +  E+L   +TE+++ I    + L A     +TL Q+ E    +++L+ + +   +
Sbjct: 3894 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3949

Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
            ++      L EL        ++ Y+  ++    + ED   R   +DE   + +    +++
Sbjct: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4009

Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
            Q+  S++ +++  +    +  EV  +  +    +  +K V + +E L+   E L+   +E
Sbjct: 4010 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4065

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
              +  G  +K               A+ +++K       W  ++  + ++  K   +++L
Sbjct: 4066 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4113

Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
             + +   H      +K  +   + L +  +  + + +    A + I+E    +Q+  +  
Sbjct: 4114 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4172

Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
            +   S L        +P    +   L     SL +A       LE+ +            
Sbjct: 4173 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4232

Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
             F++V      L+     G  LE++K  I   ++     +QQ+ E     LNH   L   
Sbjct: 4233 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4288

Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
               ++ + E S K  + D     L  +   W       + R  +L+G  L   +F +  +
Sbjct: 4289 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341

Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
            + +  L   E  L         P+ +E +   + +L+ +V  +Q+  ++       L+++
Sbjct: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4401

Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
            +  E       +   L  RWQN ++   QRK  +DG +RQ + F   +E+L ++LTDT  
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461

Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
             L A K      L        E  N  +     F+ +  T    ++ G+++L       +
Sbjct: 4462 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4516

Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
             ++ + I+ L++ W+ +E +L E   + +  +    E  +  +  I  L    Q L   S
Sbjct: 4517 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4576

Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
               L  + + +  + +  K     + S  + + EL      L      +DV+++K  +  
Sbjct: 4577 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4634

Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
            +  +WE +  R+  R + ++D       F+E   +L  WL + E  +    +I+ +    
Sbjct: 4635 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4694

Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
            K Q    K+  + +           + G  L  K S      ++DD L+++ D+W  +  
Sbjct: 4695 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4754

Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
                R  KL+E   F  Q    +  L  WL R+E +L+  +PV  D+     +   +   
Sbjct: 4755 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4811

Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
            +  Q+++ + ++ V+++      L+  S       +   ++   + L  RW  +CA+S+ 
Sbjct: 4812 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4866

Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
            ++ ++E   R  ++F        +WL  AE+T       P+  + L T     + + + F
Sbjct: 4867 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4922

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
             +++ E+  +L         +      D+ + +K  +     R++ +        +RL  
Sbjct: 4923 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4982

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
                    +   E++L WL   +  LT+ +        ++++ L      F +E+T    
Sbjct: 4983 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5042

Query: 6299 KIDQL 6303
             +D++
Sbjct: 5043 DVDKV 5047



 Score =  197 bits (500), Expect = 4e-49
 Identities = 113/266 (42%), Positives = 148/266 (55%), Gaps = 35/266 (13%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT WIN  L +      ++DL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 72  ERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 129

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +L+ R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 130 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 180

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  MSA++ LLLW Q+    Y  +   +F 
Sbjct: 181 -------DIHVTGESE----------------DMSAKERLLLWTQQATEGYAGIRCENFT 217

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           + WR+G  F AIIH  RPDLIDM +V  +SN  NL  AF +AE ++ + RLL+PEDVDV 
Sbjct: 218 TCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPEDVDVS 276

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE 293
            PDEKS++TYV+         P  GE
Sbjct: 277 SPDEKSVITYVSSLYDAFPKVPEGGE 302



 Score =  193 bits (490), Expect = 6e-48
 Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)

Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
            N  EE  N  FV   L+  D   +Q    ++ +    +   ++  ++  +A+E+F +SL+
Sbjct: 637  NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 696

Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
             AK+          S+ Q+     LT   K   +H ++       +  K+L+ S ++ ER
Sbjct: 697  EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 736

Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
              DT    +  A +  I L+E     V  +++E N  +      + EL++       NI+
Sbjct: 737  HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 796

Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
             VQ    ++ L++    +    +R     +   +L   +  ++H++E       F D +E
Sbjct: 797  SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 856

Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
             T               C  +  +    + LV E +E+   +L+      N      T+I
Sbjct: 857  ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 915

Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
            Q     S   L+ S   K     R  EI I K++      N H     K   +       
Sbjct: 916  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 972

Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
            +     F  PP  KEA       +D+  + E  Y+N+   L LW +   N+K+V+  W  
Sbjct: 973  MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 1020

Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
                    + + E DR R      +      E  + ++ +Q   +   E   E QV   S
Sbjct: 1021 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1072

Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
             + ++E  V  C               +  ++L ++  +    ES+   L  S+   I  
Sbjct: 1073 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1117

Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
            +LE  + ++++Q  + +    L   +  +T E  +LKK+ E + D   T  +  ++ FS+
Sbjct: 1118 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1176

Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
               +          + +  N+ + +  S T                      K+K V+ V
Sbjct: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1217

Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
            LK+ +  + L K +  +L     ++  +  +E + S  +    E+++  Q    L+D+  
Sbjct: 1218 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1275

Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
             L+K     +E +K  +E     +   +   +  E++++V  Q++N L++  G  +  + 
Sbjct: 1276 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1334

Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
              +    +D    + +T  R++ E + E  K L T+      L  ++     E+K+S M 
Sbjct: 1335 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1388

Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
                E +   E+    +K+  L      A +++     + ++   S A L+ +   D+  
Sbjct: 1389 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1445

Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
            ++   + L + Y          L  +EK L E +K +++  ++L+  +      LK  ++
Sbjct: 1446 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1505

Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
            AG       +    ++   K+ L +A     L   L   G+ + +  +N    +   L+ 
Sbjct: 1506 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1563

Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
             +  L    L+QLQ+S  + D  V         +E+      + DL T  +N     +E 
Sbjct: 1564 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1623

Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
                D  V+    + K ++LQ+         G+ + +  + K+ +      G+K+ ++D 
Sbjct: 1624 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1676

Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
            K+L      +E +L  AK +   C    LK+++S ++         +K  T+ ++E T++
Sbjct: 1677 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1719

Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
             AAV++LEE         DW  N D   E A +K   +  Q          +S    EDE
Sbjct: 1720 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1779

Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
               N L+    ++D  +   Q E + + Y +++A+   I    Q   +  T++  ++L  
Sbjct: 1780 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1834

Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
             G   S +  + L + +  LK + E+           LA  E  MK   + +E L+    
Sbjct: 1835 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1884

Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
            D   +   L + ++ + ++E   D +  L  K        E++ +H      +T    ++
Sbjct: 1885 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1944

Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
            LE+     +    +V+     +++Q+K       +    +  N + +    L  + QH  
Sbjct: 1945 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 2004

Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
                 L   L++ E  A       +  D   LQ        L+GQ   Q   +   K+  
Sbjct: 2005 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2064

Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
                         K +++  ++++  ++E L     E   ++     +   +++ + E +
Sbjct: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124

Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
             W  N+   L     +PL    +   I K  +    I  RQ S+ ++ E+VK  + +   
Sbjct: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184

Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
               S L   ++DL  ++     K  +   ++E +L+ +   F  + +      E++T  +
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2243

Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
              V+    +            +E   H   LE     L+EI S G+ +   +   + E+ 
Sbjct: 2244 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2300

Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
            N   + F  +ED +K  K      Q  +      V+    + ++  +K   +Q       
Sbjct: 2301 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2360

Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
                 E+   +Q    L   E+    N G+   + NL   +T     I  V     V + 
Sbjct: 2361 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2418

Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
             G          N   + + +  T +    ++    L++KI +L+T   +  K Q    +
Sbjct: 2419 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2475

Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
              A+   ++KM +   K           A  +  E  +     L Q + K + L D++ +
Sbjct: 2476 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2535

Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
             L EN    ++ + K++L       E D  ++ L  + ++   K  +  N   + +T   
Sbjct: 2536 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2589

Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
             L Q  ++ +L   +L  ++++   +  ++   +   ++        + +TA    I  +
Sbjct: 2590 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2649

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
              E+ S    V+ +L         L   +  R + ++ A    T+Y+  +    + ++ L
Sbjct: 2650 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2709

Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
            +     ++ +    D  N  + LE   + ++E++     I   Q L E L       A +
Sbjct: 2710 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2761

Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
            + +Y   EL  +   + ++FK  E +AE ++++ +        +++M  D     + ++T
Sbjct: 2762 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2818

Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
               +   S P+S + + LE L     + SK L +     ++ + +   +  LL+ + +E 
Sbjct: 2819 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2876

Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
              + L L  +   W+                     K+   +E    W   C+   +E K
Sbjct: 2877 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2936

Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
            F  +  E E  I  L +LQ+E+ +                 + +  +   T+E   L+  
Sbjct: 2937 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2996

Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
            +    E +  ++  L  + Q+ +  Q V + S      A E +     + S     +   
Sbjct: 2997 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3056

Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
            +LQ  QK+ + ++ ++       ++++   +  + T+     +    Q+H   S+Q +E 
Sbjct: 3057 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116

Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
             S L+   +G   F+N + ++  +++E    +   A +    E  +K  E I   +   E
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3176

Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
             L +S   A     M    EE +  L     ++E + +Q +K +++AQ  ++++      
Sbjct: 3177 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236

Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
            L+ ++SKL E    +Q   E +  Q    M+   I                P Q  QQ  
Sbjct: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296

Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
                                             ++++   R +QL +A +    + D L+
Sbjct: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356

Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
            S  +W+ +T  L+AN     A++  ++        +Q  L+D   + + +  I  + E +
Sbjct: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3413

Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
            +   E  +  + +++LS   ++  AL  K      Q++ ++         ++ + + ++ 
Sbjct: 3414 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3473

Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
            I+  L++ E         EE +   + + ++I    K + + VS    L++  +      
Sbjct: 3474 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3533

Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
            V  + +        ++  +  ++ELL+  +     + E+   L   LN    + S   + 
Sbjct: 3534 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3593

Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
                + L + Q E+  +++ IL   Q  +  L++    LK T  +    ++ + E + + 
Sbjct: 3594 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3652

Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
            R   +T     VA+      +L RR         ++L  VE E+     +   G+E  +A
Sbjct: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712

Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
            +  P+      K++K + +     SS  +       +E   K+   DN   ++++   + 
Sbjct: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772

Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
              E+     LR  Q ++            ++DA+       EK               + 
Sbjct: 3773 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3809

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            ++ L   Q +  ++       +Q+    +++  + ++ ++      ++  C ++      
Sbjct: 3810 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3856

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
                E +++  KL  V  N + +  +  E++ + +    L       ++E L P  L+E 
Sbjct: 3857 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3910

Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
            +SI+++ P      +  RQ+  + +Q+ EL   E K  I        K  PQ  +    +
Sbjct: 3911 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3965

Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
              + QE   +A    S  + DV       D  +S   Q  DK   +   L   + +L  P
Sbjct: 3966 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4025

Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
                   + ++ Q+S N  +   +      Y T ++                  K    +
Sbjct: 4026 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4085

Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
            L+ +     N+ T     E   ++   L +K +     L +T+      + + LE P + 
Sbjct: 4086 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4144

Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
                  QQ   ET+  E+  L   L    +   +L+ A   P  +  ++ +  D L    
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4202

Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
            +    A   R   L+  +     YQ+ ++ ++  +      + S + +   L  +  Q  
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4262

Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
              +  K++AY  ++E       AE  + K+ +E ++    + +   + +L+ + DS+   
Sbjct: 4263 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4318

Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
            +  R  +L    +   Q Q AL + +  L      + ++K   G  K  + ++A    ++
Sbjct: 4319 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4378

Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
            N  +  Q  V     A   LI++ SA    S LQN+     ++   V    EK+ Q   +
Sbjct: 4379 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4434

Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
            L   L++ + F      L++ L      L+++ P   L E  +E+L    + + ++    
Sbjct: 4435 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4490

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
              K       + +G+Q++A   CP+     ++  I  L+E+W S+  K++    +L+  L
Sbjct: 4491 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4548

Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
               + ++        WL  ++ TLN     SL     LDT+   I+    F+ EV   +S
Sbjct: 4549 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4601

Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
             +  +I +     HLK    + D   ++  L   + +W  ++ +L +    L   +    
Sbjct: 4602 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4661

Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
               +A ++++ W+   E + S +  +   +   ++K  L +HKEF+  +  K  + D  N
Sbjct: 4662 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4719

Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
            ++   L   +  S   +  +  + L E+  +W  + G    +   LE+ L    +  + +
Sbjct: 4720 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4777

Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
            Q L +WL   E +L   Q     I  V  L+ + +  + +L  ++ ++  LK+S   L  
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4837

Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
            G+     D +S +    Q+ S+    V  L  S Q+ L+      + +  V    + +  
Sbjct: 4838 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4891

Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
             +  ++  +     L    + L++L D+ +      E+ +  + K   +  +V  I    
Sbjct: 4892 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4950

Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
               T K W  + +A  +++       Q   A + A   A   L +    + Q A  +++ 
Sbjct: 4951 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 5010

Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
             +  E++P  ++++K L  + Q   E   +    +D++
Sbjct: 5011 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047



 Score =  183 bits (464), Expect = 6e-45
 Identities = 676/3660 (18%), Positives = 1402/3660 (38%), Gaps = 447/3660 (12%)

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
            +E L+   R+++E      +I ++      + + E +L  Q  ++  + ++   +  F+ 
Sbjct: 1089 QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ--IRTPLERDDLHESVFRI 1146

Query: 3350 QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPL-SYREALERLEQSKALVS 3408
             E E  +     K   ++++D+ T  +K E    Q+ +S  + + R  L  + Q+   V 
Sbjct: 1147 TEQEKLK-----KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201

Query: 3409 NLISTKEELMKLRQIL--------RLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEW 3460
            ++ ST  + +K   ++         L++L  T+   +C  + V A      +L+   K+W
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK---LCEEEAVIADKNNIENLISTLKQW 1258

Query: 3461 EMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGEN 3520
                +E +Q +  + +E+++   I D + +   E          +   E  D L +  +N
Sbjct: 1259 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE-----RDLDFDWHKEKADQLVERWQN 1313

Query: 3521 VEKQQLLLTLLLQRIRSIQNVPESSGAVETV--PAFQEITSMKERCNKLLQKVQKNKELV 3578
            V  Q      +  R+R ++ + +S         P    I  ++    K+ +   +N + +
Sbjct: 1314 VHVQ------IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1367

Query: 3579 QTEIQERHSFTKEIIALKN-------FFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKG 3631
             T++ ++     EI   ++       + +Q + + ++   Q    ++    + +S +K+ 
Sbjct: 1368 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1427

Query: 3632 K------LTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPS 3685
            +      L  +  M+ LR +Y+ + T++   I+   +  ++  E+  EK   E  K    
Sbjct: 1428 RMQSSADLIIQEFMD-LRTRYTALVTLMTQYIKFAGDSLKRLEEE--EKSLEEEKKEHVE 1484

Query: 3686 YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQ--- 3742
                 K +E+   + N+ K L+   K  +     QK   +E+     +L+E    +Q   
Sbjct: 1485 -----KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1539

Query: 3743 -----DIVEQDPGQAQEWMDNLMIPFQQY--QQVSQRAECRTSQLNKATVKM-----EEY 3790
                  + +++  + ++ +  L   +     + + Q  E +TS   K   K+     +EY
Sbjct: 1540 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEY 1599

Query: 3791 SDLLKSTEAWIENTSHLLANPADY----DSLRTLSHHASTVQMALEDSEQKHNLLHSIFM 3846
             + L+     +  T + L    +     D    L  + S  +   +D +     L  +  
Sbjct: 1600 KEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVK 1659

Query: 3847 DLEDL-----SIIFETDE--LTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESE- 3898
            + E+        + + D+  + Q + E   +   L  K  +S  ++ ++    +  E+E 
Sbjct: 1660 NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1719

Query: 3899 ---VKSMEKRVSKIKTIL--LSKEIFDFSPEEHLKHGEVILENIRPM-----KKTIAEIV 3948
               VK +E+  +KI+ +L  LS    D S     KH +VI +N         K  I E  
Sbjct: 1720 VAAVKQLEESKTKIENLLDWLSNVDKD-SERAGTKHKQVIEQNGTHFQEGDGKSAIGEED 1778

Query: 3949 SYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLEN--VTQEQNELL-----KVVIKQTNEW 4001
                 L       +     +  NQ  Q +K      ++Q Q  ++     +V++++  ++
Sbjct: 1779 EVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY 1838

Query: 4002 --DEEIENLKQILNNYSAQFSLEHMSPDQADKLPQ-LQGEIERMEKQILSLN---QRKED 4055
               EE E L++ +      +       ++  KL   LQ E+E+ +          Q+ E 
Sbjct: 1839 LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1898

Query: 4056 LLVDLKA---TVLNLHQHLKQEQEGVE-----RDRLPAVTSEEGGVAERDASERKLNRRG 4107
             L +L+A    +  L   LK+++   E     +  L  +T     V E   S  K  R G
Sbjct: 1899 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSK--RDG 1956

Query: 4108 SMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEE--DRASSSSGTIVQE 4165
                 +A   EV+    K D+  ++        + L  + KD+ +       +S  ++  
Sbjct: 1957 GKVDTSATHREVQR---KLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAG 2013

Query: 4166 AYGKISTSDNSMAQILTPDSLNTE---------QGPECSLRP-----NQTEE------GT 4205
                 +T+   +++ +  D  N +         QG   S +       +T E      G+
Sbjct: 2014 LQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS 2073

Query: 4206 TPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQ-------VAELELWLQQANVA 4258
              P + D   + D   G    + K+  E  E L    T+       + E+  W+     +
Sbjct: 2074 LLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESS 2133

Query: 4259 VEPE---TLNADMQQ-------VLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGAT 4308
            ++ +    LN+   Q       +LEQ + G Q+ +  +  KV   +ET            
Sbjct: 2134 LKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS-------- 2185

Query: 4309 QHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSE-LE 4367
               A +L  K+K +     +       KH E    T+ K        E  +  NLSE L+
Sbjct: 2186 --TASSLQAKMKDLSARFSEAS----HKHKE----TLAKMEELKTKVELFE--NLSEKLQ 2233

Query: 4368 SIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAK-----KMWPQYCQHD--NDT 4420
            + +  + Q   + D   + V EL    Q+   +F+E          +  +   H   +D 
Sbjct: 2234 TFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2293

Query: 4421 TQESSASNQASSPENDVPDSILSPQG------QNGDKWQYLHHELSSKIKLPLPQLVEPQ 4474
                  +N  S    ++ D+I   +       +  D +Q L   L S IK    ++  P 
Sbjct: 2294 ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PI 2351

Query: 4475 VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNL-QTQENMTEEAYINLDKKL 4533
            V  + G               E+    T +++ +     +L      +T  A      K 
Sbjct: 2352 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2411

Query: 4534 FELFLTLSQCLSSVEEMLEMPRL--YREDGSGQQVHYETLALELKKLYLALSDKKGDLLK 4591
                L      ++ EE      L   ++D +     YE L L LK     L+ K   L K
Sbjct: 2412 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK 2471

Query: 4592 AMTWPGENTNLLLECFDNL-QVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
            A     E ++ +++    + +   +  Q  A   ++++K  ++ N+S++ E+K+  +++ 
Sbjct: 2472 AQ----EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2527

Query: 4651 KSKTSLQQSLNEISGQSVA----EQLQKADAYTVELENAE-SRVAKLRDEGERL---HLP 4702
            + K  L + L E      A    + L + D+   EL      R  KL +    L      
Sbjct: 2528 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2587

Query: 4703 YALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA--- 4759
             A L++    ++++ S+ G L      L+    T+ QQ  +L       K   E+L    
Sbjct: 2588 EAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKPQYEQLTAAG 2643

Query: 4760 HGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
             G L +     +L+            +V + L         L   L +R   W +Q    
Sbjct: 2644 QGILSRPGEDPSLRG-----------IVKEQLAAVTQKWDSLTGQLSDR-CDWIDQAIV- 2690

Query: 4820 KILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVE-ETEERLVERI 4878
                 KS Q    L+SL  K  + D   +S      + +ST P     + ET +++ + I
Sbjct: 2691 -----KSTQYQSLLRSLSDKLSDLDNKLSS-----SLAVSTHPDAMNQQLETAQKMKQEI 2740

Query: 4879 SFYQQIKRNIGGKHARLYQTLNEGKQLVASVSC--PELEGQIAKLEEQWLSLNKKIDHEL 4936
               QQ K+ I     ++ Q L E    +        EL  Q+  + + +  + +K ++ +
Sbjct: 2741 ---QQEKKQI-----KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHV 2792

Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
              LQ+       + + S     WL++ +   N    +S  +S  LD + S I +  +FSK
Sbjct: 2793 QHLQSACASSHQFQQMSRDFQAWLDTKKEEQN----KSHPISAKLDVLESLIKDHKDFSK 2848

Query: 4997 EVDEKSSLKTAVISIG-NQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
             +  +S +    I+ G N LL  + ++ A L+  L   +  W     Q+ + + KL +  
Sbjct: 2849 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2908

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
             + L  ++ +  +  W++  ++   +      P+     ++ + K K  + EMD    +V
Sbjct: 2909 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG---ENSIAKLKSLQKEMDQHFGMV 2965

Query: 5116 DFVNQ---SLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESI 5172
            + +N    SLL +   D E    E     + +  +  Q H     L    Q  ++  E  
Sbjct: 2966 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 3025

Query: 5173 TESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQS 5232
             ES+ ++Q     L+  +         + +  +Q      Q +++Q+ +  +   +L   
Sbjct: 3026 KESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL--- 3082

Query: 5233 YLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMM 5292
               +E+       D   +++ + Q+ S++  QV++  + +++ LQ    +     E+   
Sbjct: 3083 --VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3140

Query: 5293 TIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---SEGSWEKLQEVIGKLKGLCP 5349
               F   ++   PV    ETL+ Q E +++   + E+   S  +  K  +++   +   P
Sbjct: 3141 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3200

Query: 5350 SVA------EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQ 5403
             +       E + ++C     R     + +   +++ +      K +S    +A    + 
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3260

Query: 5404 QEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESS 5463
            Q     +   I+   N         ++ ++  Q DV    +  +Q++         A+S+
Sbjct: 3261 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA---------AKST 3311

Query: 5464 THMLLPGPLHSLQ-RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDR 5522
            +   L   L  +  R   L K +  +A + +  L     F   LESL   ++  EE +  
Sbjct: 3312 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3371

Query: 5523 LHQQEKE--------NPDSFLNHVLALTAQSPDIEHLNEVSLKL-----PLSDVAV-KTL 5568
                  E             L  +L    +   +E +     K+     P   V + K L
Sbjct: 3372 QKPPSAEFKVVKAQIQEQKLLQRLL--DDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3429

Query: 5569 QNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEALK--VDVANSLP 5625
              ++ +W      A  R  +L+GI +  ++F    E   + L  IE+ L     +     
Sbjct: 3430 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3489

Query: 5626 ELLEQQKTYKMLEAEV-----SINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
            +L EQ   +K LE ++      ++Q ++   + QSL++L + E ++  +   +FS++   
Sbjct: 3490 KLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDFSQV--- 3543

Query: 5681 WQNAVQGVRQRKGDV-DGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFS--LYQT 5737
            W   +Q     + ++    +   + F      L  +L +    LS +  Q+  +  L++ 
Sbjct: 3544 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3603

Query: 5738 RSLIHELKNKEIHFQRRRTTCALT--LE-----AGEKLLLTTD-LKTKESVGRRISQLQD 5789
            +S +  L+ ++I  +++    AL   LE      G+++L+  D L+  ++  + I++L  
Sbjct: 3604 QSELRVLQ-EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3662

Query: 5790 SWKDMEPQLAEMIKQFQSTVE---TW-DQCEKKIKELKSRLQVLK----AQSEDPLPELH 5841
                   Q  ++ ++  ST E   TW D+ E ++  L    QVLK    +Q++    EL 
Sbjct: 3663 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL--LSYETQVLKGEEASQAQMRPKELK 3720

Query: 5842 EDLHNEKELIKELEQ------SLASWTQNLKELQTMKADLTRHVLVEDVMVLK-EQIEHL 5894
            ++  N K L+  L +       L  W       + +  D  R+ LV D +  K E+I+  
Sbjct: 3721 KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-- 3778

Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEK 5954
                        +R Q+          F++      +W+ + E K++   DI +E+    
Sbjct: 3779 ---------AAILRSQQ----------FDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3819

Query: 5955 LQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-------EIDDKLNKINDRWQHLF 6007
             Q   ++    F+   L+ K + D L+K+ +K   A        +  KL+K+   +  + 
Sbjct: 3820 AQ---LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTIC 3876

Query: 6008 DVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ 6067
             +   R  +L+   + + Q  +    L  WL   +S +S+ +     + + ++++  E +
Sbjct: 3877 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPALEYETLRQQQEEHR 3935

Query: 6068 DLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMER 6127
             L+  I +H   ++ +      LL  S       E  SIQ+   + D  +  I     +R
Sbjct: 3936 QLRELIAEHKPHIDKMNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKEDVKKR 3990

Query: 6128 RMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIH 6187
             + ++E      +F D   +  + L+        P S        KE++   +     + 
Sbjct: 3991 AVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME 4050

Query: 6188 ERLTQLELINKQYRRL-ARENRTDTASRLKQMVHEGNQR---WDNLQRRVTAVLRRLRHF 6243
            +     E + ++   + AR   TD     K +  + +Q    W+N+   V     +L   
Sbjct: 4051 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4110

Query: 6244 TNQREEFEGTRESILVWLTEMDLQLTNVEH--------FSESDADDKMRQ-LNGFQQEIT 6294
                E+F     S++V + +    + ++E           + +A + +R+ ++G Q+E+ 
Sbjct: 4111 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4170

Query: 6295 LNTNKIDQLIVF----GEQLIQKS--------EPLDAVLIE--DELEELHRYC------- 6333
            +  N   +LI       + +++KS        + L+    +  D+LEE  +         
Sbjct: 4171 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4230

Query: 6334 QEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPS-SPQS 6392
            Q VF  V     +L S +P   D +   +    +E+ ++ ++++++++ E E  +   + 
Sbjct: 4231 QAVFDWVDIAGGKLASMSPIGTDLETVKQQ---IEELKQFKSEAYQQQIEMERLNHQAEL 4287

Query: 6393 LCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGH 6452
            L   V    ++   + P+    + L WD   +   +  H+          L G  ++ G 
Sbjct: 4288 LLKKVTEESDKHTVQDPLM--ELKLIWDSLEERIINRQHK----------LEGALLALGQ 4335

Query: 6453 SWHVPDSPSCPEHHYKQMEGDRNV----PPVPPASSTPYKPPYGKLLLPPGTDGG--KEG 6506
              H  D       H + +  ++      P         +      +L    T     K G
Sbjct: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4395

Query: 6507 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQ---LNSDISAI 6563
              ++  +  +E   L    E  +    RW+ +  +    K ++   L+Q    + +I  +
Sbjct: 4396 NDLIESSAGEEASNLQNKLEVLN---QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDL 4452

Query: 6564 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 6623
              WL  TE  L   K      +  + +L V    E+  AF+  +    S+    ++ L  
Sbjct: 4453 QQWLTDTERHLLASKPLGGLPETAKEQLNVH--MEVCAAFEAKEETYKSLMQKGQQML-A 4509

Query: 6624 ESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6681
              P+S E  +   +  L   WE+ +  ++  +  L ++L    +FH   Q+ + WL  A+
Sbjct: 4510 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4569



 Score =  181 bits (458), Expect = 3e-44
 Identities = 668/3660 (18%), Positives = 1377/3660 (37%), Gaps = 503/3660 (13%)

Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
            E +LEN+K   +  E+  ++L + +    Q  + L L+Y E L RLE   A    L++T 
Sbjct: 675  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 731

Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
                +    L     R T             +W       E A +W      + ++ K  
Sbjct: 732  RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 780

Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
              E+ RE   LD  +E +  + +  E    E     L  +  Y   ++ Q   +  L Q 
Sbjct: 781  HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 836

Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
            +   Q++ E++   E     +E T         +Q+         + K ++LVQ  ++E+
Sbjct: 837  VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 894

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
                +    + N   +  T  Q       P  S+          K  +  + I +  +I+
Sbjct: 895  EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 942

Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
                 TI   +         +A   +     NE +  S  +     +   N    ++   
Sbjct: 943  I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 994

Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
            ++Q+ +N+             +  WH  +NE+D    S V  I    PG+ Q+ + NL  
Sbjct: 995  IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1054

Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
             F+ + + SQ ++  +    +QL K   V  + Y +LLKS E   +  S      ++  +
Sbjct: 1055 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1114

Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
            +R  L +    +   +    ++ +L  S+F   E   +  E + L   +  ++N+     
Sbjct: 1115 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1174

Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
             Q     S+P ++   + V+   ++V SM    + K+KT+ L      + E      E  
Sbjct: 1175 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1234

Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
            L   E ++ +   ++  I+ +  ++ E+       +   VF      LQ  K + +    
Sbjct: 1235 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1284

Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
              E+ K   ++  ++D   E   Q++  +       H+  D  ++L  L+G I +  K  
Sbjct: 1285 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1335

Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
                   +D +  ++ T     + +++ Q    +     +  ++  V+E +  + K++  
Sbjct: 1336 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391

Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
            ++ +  Y A V++ E++  + ++    ++  P              ++  R  SS+  I+
Sbjct: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1437

Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
            QE +  + T   ++  ++T       DSL   +  E SL   +                 
Sbjct: 1438 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1496

Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
                   E+   PP     + S +     E   E                T  E  E+  
Sbjct: 1497 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1556

Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
              KT      L   ++           +V VE E + A+ QQ  +++L G   +LT+ E 
Sbjct: 1557 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1615

Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
                H+ AF++     E  K Q   +    Q + +  +  L  V  N E       EK S
Sbjct: 1616 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1673

Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
            ++    I +K +E + +   + +NL       EL+ +VT   +   +K    +Q+ E K 
Sbjct: 1674 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1731

Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
              +   D++  ++ ++++   ++ Q    N T  +      A   E++V          N
Sbjct: 1732 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1781

Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
            G+                   L+E  V   +G                     TTQ E+L
Sbjct: 1782 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1800

Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
             Q+   ++ Q    +++   + +  +  ++ L       S EE  ++ +  +E     +V
Sbjct: 1801 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1856

Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
            HYET         LA S+KK  L  ++          LE FD      EH    +    +
Sbjct: 1857 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1901

Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
            +L+AG D       ++KR       +I  K  L+     ISG  V   A+   K D   V
Sbjct: 1902 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1959

Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
            +       V +  D   +R    Y+    +   L+D++D         Y + S   +   
Sbjct: 1960 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 2014

Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
            Q  +    + + E + +  + L    L++TK   ALQ QI + +V  +KL     ++   
Sbjct: 2015 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2070

Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
               +LP+    ++T   + V   + L +   +   KLQ  L +     +    +   +  
Sbjct: 2071 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2129

Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
            + S+L     V      L + IS    ++++I G+ + +     + K+ + +    +   
Sbjct: 2130 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2189

Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
            L+ ++  L  ++   + K    L +++ L   +  +   S++L  +LE+    L      
Sbjct: 2190 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2249

Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
              +V++    ++ + + F E  K ++   SL   + S      H   +D A +       
Sbjct: 2250 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2303

Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
             +K+  +   + + +E +   Q +    +  +  + SW+     +T+ +  +  PS  A 
Sbjct: 2304 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2359

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
             +   L+  K+ + +   K   +  VN S + L                     +  + E
Sbjct: 2360 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2419

Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
                   EF  + G         +++  +  +  +L  KI  L   L  + +++ +   +
Sbjct: 2420 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479

Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
              WL+   +     Q+   P    +V+  +   +  E +L      + ELK     L   
Sbjct: 2480 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2539

Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
              ++   P  +   + ID  +Q+       R   L + +   T  Q+V   L++W +  +
Sbjct: 2540 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2599

Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
            L   V               P+ +    L  Q + +Q L  E  + +  +E+L    Q +
Sbjct: 2600 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2646

Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
            + +  G  PS+  I++E+     ++W  +   ++D+       +     Y +     + +
Sbjct: 2647 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705

Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
            L   + K      +S   + + + L  A +  +E+Q + ++ K  +A  ++ S L +  +
Sbjct: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2764

Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
              ++     L G L S     Q+A  +++ +    A+  +F     +DF   L++ K   
Sbjct: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2820

Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
              EE+N        LD L    K++ D        LTAQS   E        + LK   S
Sbjct: 2821 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2874

Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
            + A   LQ   +   W        ER ++L+     EK L   E+      WI   +   
Sbjct: 2875 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2932

Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
            E +K      +  NS+ +L   QK        V +    A+S       LL   EI+   
Sbjct: 2933 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2983

Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
            E +T+ +K L  +     + +  +K  ++ + +++++F    +   R L      L    
Sbjct: 2984 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3043

Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
            ++  Q   + Y T   + + + K +   + +   A  L A + ++  +D K    V  ++
Sbjct: 3044 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3099

Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
              +      +  Q+ E     ++ ++     +  I+E+ S+      +  S  P+    E
Sbjct: 3100 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3159

Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
             L  +KE IK   + L A    N    +T K  L       D++ +K  +E L +Q   L
Sbjct: 3160 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3219

Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
              R   R++++E  +     F  K KE    L + E        + +E         M +
Sbjct: 3220 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3279

Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
              QK   EEI      +  +  +G  LI+++ KS + + ++  L+ +N RW+ L   +  
Sbjct: 3280 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3336

Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
            R  +L+E      +    + +L +W+   E EL         + + ++ ++ EQ+ LQR 
Sbjct: 3337 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395

Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
            ++   + VE       V+  + +  A   E  D ++  +    LD RW  +   +  R  
Sbjct: 3396 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3448

Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
            ++E    + Q+F +      +WL + E+            +  +E++ + +A +  I   
Sbjct: 3449 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3508

Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
            ++ L Q   I +  + L+ RE++    S+L     + +Q W   +Q +  +    L+   
Sbjct: 3509 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3563

Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
               + F      ++ WL E+  +L+  +V+ +S      +  +L   Q++I L    +DQ
Sbjct: 3564 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3623

Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
             ++ G +L++++   + ++I+D+LE +    +++            +  +  RRL S   
Sbjct: 3624 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3683

Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
              CT   + E E    ET +            P+E++ ++   +   +  +   S    +
Sbjct: 3684 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3743

Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVP 6457
             P   R G E  V+ D+   E         +   EE +     S    ++     SW   
Sbjct: 3744 VPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3800

Query: 6458 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6517
                       ++E D+    +    +   +    K ++    D  K G +++    ++E
Sbjct: 3801 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII---DDLVKSGHKIMTACSEEE 3857

Query: 6518 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6577
               +    ++    +D    I ++      + +  + Q       +  WL +T++ +  L
Sbjct: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3917

Query: 6578 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
                P  + + +  + +  +++ +    +K  +  +N +  + L+    E   +Q +   
Sbjct: 3918 --PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3975

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADP 6696
               L+   +  V      L +++ Q   FH     +L  L     R RQ   ++   A+ 
Sbjct: 3976 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS---AEV 4032

Query: 6697 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              + E   E   +  ++ + QP  + L++    ++ +  G D    +     ++ KL Q+
Sbjct: 4033 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD---KDISAKAVQDKLDQM 4089



 Score =  174 bits (440), Expect = 4e-42
 Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)

Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
            LQ Q E  K F +KL A ++     + K    +L   ET   + V   + LE  S+QC  
Sbjct: 3161 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3217

Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
                LL + +  +E      K LE   S L   S+       L+++   +++ +  +G +
Sbjct: 3218 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3267

Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
               + Q LN             +GKQ                S S   LE  +  +  +W
Sbjct: 3268 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3327

Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
             +LNKK+     +LQ  L H   +    + L  W+  ++  +   K  S     +   ++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3383

Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
            + I       + +D++ S    +   G ++    E  D   +   L+  + +W  L+ + 
Sbjct: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443

Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
                 +L  + +      + +  +  W+  +E +  + + + +   AS+++  + +HK  
Sbjct: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3501

Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
              ++ ++ + +   V+  QSL  LS+ + +     + +F++        W+  +    + 
Sbjct: 3502 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3554

Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
            + + L+Q L  +    E++++++N WL    ++L  L            Q+ E  +  + 
Sbjct: 3555 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3613

Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
            +LL  Q+++  L      L+ LKQ+        V +++D    I   ++  + + T V +
Sbjct: 3614 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666

Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
             L+ ++Q   +    +++L   ++ + +     + +   V+   E  + Q+   + L+ E
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3722

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
            A++++   + L EV   L  L P  A E +E+     ++R+  V+  I  ++++  + + 
Sbjct: 3723 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3782

Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
              + +  A     + + + E K   L +I +             QD    Q  VQKT   
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3830

Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
              L++  ++D L +    S H ++     S +    ++K L      ++ +     +  +
Sbjct: 3831 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3884

Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
            +LE  + L+    E  + L     E   S ++ + A   +   +    E   +L      
Sbjct: 3885 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3943

Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
             K  +  MN+     T   L   S  +G  + EK++     + Q+ E +       +EA+
Sbjct: 3944 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3998

Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
                    K+D +  SL  ++E+ +    + AEV  I + I++    S   + LQ L  T
Sbjct: 3999 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4058

Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
             ++ R E +   S  TD+  +A    +  +  +D +V  W++  T VE            
Sbjct: 4059 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4113

Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
              +F  D   L+  +K  + F           S+ + +    E   +EI   +      +
Sbjct: 4114 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4173

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
             L  G +L+       K  V + I +L  +W  +     + I + +  ++   Q +  ++
Sbjct: 4174 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231

Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
             +   + +   +     P +  DL   K+ I+EL+Q  +   Q   E++ +  +A+L   
Sbjct: 4232 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4290

Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
             + E  D   +++ +  L   W+ L  R+  R+ ++E  L     F     EL AWL   
Sbjct: 4291 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4350

Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
            E  + +   +  +     IE  +   ++   L  ++ ++ + + G+ LI++S    A+ +
Sbjct: 4351 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4410

Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
             +KL  +N RWQ++ +    R ++L       +     + +L+ WL   E  L  SKP+ 
Sbjct: 4411 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4469

Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
                    + +   EQ ++  ++     A  E+  ++          C    E + I Q 
Sbjct: 4470 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4522

Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
              +L  +W ++     ER+ K+EE   L  +F +    F +WL  AE+T    +   ++ 
Sbjct: 4523 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4582

Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
             +   ++   + F  +++    Q+  ++K    L   ++      +K ++     RW+ +
Sbjct: 4583 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4642

Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
             +R+    R L     + ++F      ++ WL E +  L + +E  ++ D    ++ Q  
Sbjct: 4643 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4702

Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
             FQ+ +    +  D     G  L +K+   D  L ++D L EL      + G+
Sbjct: 4703 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4755



 Score =  160 bits (404), Expect = 5e-38
 Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)

Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
            LT  S    LS G T+ L   +  A T     G+  +    + P+ SL+   KL +I++ 
Sbjct: 570  LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 627

Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
            +L  K S++   L E +I       L   + E++ Q +     SDL + + S L++H   
Sbjct: 628  LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 681

Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
                  KN +      + +LKE  + SE + +   KL        LE + +K+       
Sbjct: 682  ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 731

Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
            ++ ++HL   H    +S    +   L + E   +  A +  +    + R +D H  L + 
Sbjct: 732  RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 787

Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
            L  +EE  K ++E  E+         L  +A  A  + Q+  + QL   ++++      +
Sbjct: 788  LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 847

Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
             E      EAT  +   +  +++    +    +   ED  Q   +   +++ +   I   
Sbjct: 848  FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 907

Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
                ++++ L       PL               E  I K  E +L      A+ + I  
Sbjct: 908  MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 967

Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
                +  P V        K   D++N    Q+ N L L   + SH     +    YL ++
Sbjct: 968  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 1025

Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
             D +R   +   K    G   +H       Q + ++ FL+ +Q        D+T L KE+
Sbjct: 1026 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1081

Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
                 Y  E  K+    E+                L +++  + L++Q++  ++  D H 
Sbjct: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141

Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
                + E +  +  +  L     T+ N  +EF S +        +  +L  + +  N++ 
Sbjct: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201

Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
                T    L     V +NT +    +   + K  +      E  + + K  +E  + S 
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1254

Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
            LK  RS   EK+  F     E Q    + +   ++     L+ DW   K D  VE   + 
Sbjct: 1255 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1314

Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
             + ++ +        +S+K   D    +++   Q       ++  Q E  + L TQL  +
Sbjct: 1315 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1374

Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
            K  +  +E       EC    E  +       L  + Y A  +D+  ++ +  ++ + S 
Sbjct: 1375 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1433

Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
              ++++F +              Y+     S+K L  +++SL+    + V    +++K++
Sbjct: 1434 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1493

Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
            ++I K         K      KI  E +S     + + L   Q+   +HG +  +++ + 
Sbjct: 1494 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1552

Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
            +  +QV    E     F+  + ++Q+++ S  ++ +++ +  R +  +E+      +   
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612

Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
            T+ +   H  + + G   +++K+   ++E+                KN E   N LK+  
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1669

Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
            E L                   E L+L+AE   K+ D  +   +KE    + A   L E 
Sbjct: 1670 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1729

Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
               I  L D   ++     +    H  ++ +            ++ EE +     L T  
Sbjct: 1730 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1789

Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
               +  T E+L  QYQ +             V+ +TQ +Q L   LE++  + +   K +
Sbjct: 1790 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1846

Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
            L     E  +      A +E ++K  H    + Q+EL++ D+  +     L    +EL  
Sbjct: 1847 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1902

Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
             E     D +  L  +  R + F ++    + HK    R      + + E A S  + + 
Sbjct: 1903 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1956

Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
              +     ++ V+ ++ +  DR  ++  KC +L    LK + D      D S   L  LQ
Sbjct: 1957 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 2015

Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
                   K L E I    K L    EE    Q  +S  +    ++KK  EV+L A  S  
Sbjct: 2016 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2073

Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
                    +L  + +  K L D+I+ +  +     +   EK  + +  +    D L ++L
Sbjct: 2074 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124

Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
              M  +E S KE     L+    QD +  ++ +   I  +      +N ++K      D 
Sbjct: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184

Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
              A   Q   +  S +   A  K +E   ++  +++TK+  FE+L  +L T ++ +T  L
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2243

Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
             +          L++Y +E+ +  +E    LE +  ++      G P +   + L K   
Sbjct: 2244 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2302

Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
            L      ++D + EK   ++S + +L         L+  ++E   K   ++ +F A++  
Sbjct: 2303 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2362

Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
              + LE+ K   K++E       +++ V    +S     S   +  +A+  ++   A+++
Sbjct: 2363 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417

Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
                +T  E     + L  ++   T      E+ G+ L   ++ L  K   L +A +E  
Sbjct: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2477

Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
                W +++ +   +W+      + EA+     Q +  E    +     +EL + L  L 
Sbjct: 2478 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2537

Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
            +   +                K Q L  L + R + ++    +    +TV A  ++    
Sbjct: 2538 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2597

Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
            KE    +L  +  +  ++ T+ Q+     +E    K  ++Q T + Q +  +   + S +
Sbjct: 2598 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2657

Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
                E+L ++ +K       + +  R  + +   +   + +S +      L D+D K+S+
Sbjct: 2658 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2715

Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
             +  S+   AM +++E        +++ +QQ+ K I+ AQ + + +   +   + K  EL
Sbjct: 2716 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2770

Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
              +++ I      VEQ      + + +      Q+QQ+S+  +     +  + NK+   +
Sbjct: 2771 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2830

Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
             K++    L+K                E  I    +LL      +       L T+  + 
Sbjct: 2831 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2890

Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
             T               ++ AL+  EQ   L   +     +LE++    +  E   SI +
Sbjct: 2891 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2950

Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
            L +    + Q   ++E L         V  I+ EV     KS+ ++V  +   L SK+  
Sbjct: 2951 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 3010

Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
             +   ++  +  EV  E+ R ++          ++         L + QT  K L   + 
Sbjct: 3011 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3070

Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  +L QD+ +              +E + QE + L + V ++ +  + +++ +   
Sbjct: 3071 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3130

Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
             N     FS      D+ D +  +  + E ++KQ   I +  ++ E L+           
Sbjct: 3131 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3190

Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
              L  E+      G++RD L A++ +   + +R A  R+    G++  L     +++E S
Sbjct: 3191 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3248

Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
            +      +KAE   +S   +      ME +       TI Q+          +M ++   
Sbjct: 3249 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3283

Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
            + +   QG +  +         +  +  +T  +E D  D +     L  +V +   +  E
Sbjct: 3284 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343

Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
             L  C              V   EL   Q   + E + + A +Q Q L Q+L+  +    
Sbjct: 3344 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3403

Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
            E+      K+A   E   K + L          EAL  K +T    LE + ++ Q+ H  
Sbjct: 3404 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3461

Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
                            E L+P+N  L+ +E  +        Q    ++Q+ + K +E  D
Sbjct: 3462 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3504

Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
             I             + +H +       +    SS E+ D+  S L       D  Q  +
Sbjct: 3505 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3545

Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
             E+  K       L +   +  +     V + N+              L ++  + S L 
Sbjct: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3591

Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
             Q+  TE     L K+  EL +     L    +V++ L       +  +G +V      L
Sbjct: 3592 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3647

Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
            E +K  Y  ++    D+ K +    +    L    + L   L+  +   +     +  G 
Sbjct: 3648 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3707

Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
            + +++ Q   K L  +  K+  +L  SLNE+S   +     +A       E  E  VA  
Sbjct: 3708 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3757

Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
             ++ ER  L    + Q+V +++  +       +A   ELS  ++TE+++  +  G + L 
Sbjct: 3758 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3814

Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
            +            QT +++ +Q     +I  HK     LV +   ++ A S +   S+ +
Sbjct: 3815 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3863

Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
              +       T  +I  E+  Q       + Q WE ++E +  L  + + +IS LP+ +L
Sbjct: 3864 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3922

Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
              ET  +  E    ++Q++  I      + +    G QL+      EL  G+   ++E++
Sbjct: 3923 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3973

Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
            ++   L  +I  ++ +    L   +S +    D++ + LES +  +   + Q  ++S ++
Sbjct: 3974 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 4032

Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
            + I+  I+     S ++++   L   +   G +++         + A   Q +      +
Sbjct: 4033 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4086

Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
             Q+  I E +H L  E+      + E+    W +++    + +D+      +  P    S
Sbjct: 4087 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4146

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
             VK   +  +  R E+D  Q  +D V N     ++ C    K   +    + + E+N  W
Sbjct: 4147 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4202

Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              ++     +I  LE+ +++  + ++ +Q + +W++    +L ++    + +   K    
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4258

Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
             Q IE     KS+A  + +     L   A  LL+      D         EL     S+ 
Sbjct: 4259 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4316

Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
             ++   +  ++  L     +    DE+          +   KPV    + +  ++     
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4376

Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
            LQ++  + + + E + +    L +      A  ++ K +  ++RW  V +    + Q+  
Sbjct: 4377 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4436

Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
              L+  K +   HGE    L+Q   + +   LA+  + G      E L   ++     + 
Sbjct: 4437 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4492

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
              +  K    +   +L R P+ AE++    +   +++L            +R   LE+ L
Sbjct: 4493 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4548

Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
             + A EF   L  F ++  + E    +       LD +  Q  E+   F N V +   Q 
Sbjct: 4549 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4606

Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
             +++    HL   S K  +  V +K L  ++  +W +     +ER   L       K  +
Sbjct: 4607 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4664

Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
              E W +L+E +EE+ K     +++AN   ++  Q   +K  +  +    ++ D+     
Sbjct: 4665 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722

Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
              L + T + ++  +     S+L D+W        +R+  ++  +     FT +++ L  
Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4782

Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
            +L      L+     E   ++    L+  L +    FQ+   +RT+    L+   + L+ 
Sbjct: 4783 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4837

Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
                    V  ++ +L   W+ +       + +L   ++Q   F S V    +   +  E
Sbjct: 4838 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4896

Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
               R   +    ED L  L   +   KE +K+LE+  A     L +  TM   +      
Sbjct: 4897 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4949

Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
            + +  +K  I  +  ++E++       +Q +   L   +   E  + L AWL   E  + 
Sbjct: 4950 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 5009

Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
                  I + IE++ K  + E   F E ++  KQ     +  + K RAA+
Sbjct: 5010 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5057



 Score =  155 bits (393), Expect = 1e-36
 Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)

Query: 616  ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
            ++L +   E  +L E     VE + ++    S+ISK L+   K  +   SK ++      
Sbjct: 1463 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1522

Query: 669  ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
                        + L + K      D   N L K+ K   E     FS  +        +
Sbjct: 1523 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1582

Query: 714  QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
             ++K  EK   E + E+  +L+   D+      +LIG  E +       ++     +  E
Sbjct: 1583 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1641

Query: 768  ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
            E  K +        E++  +E+ L+ + + +S ++         ++ K+ EAK K +   
Sbjct: 1642 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1695

Query: 828  VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
            +K   + K L  V        +  +    ++EES+ ++E+ +     +    E  G   +
Sbjct: 1696 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1752

Query: 880  KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
            KHK+ +  + T       K+     +E+  N+ E D+   +     ++  +++ +  +  
Sbjct: 1753 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1812

Query: 935  LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
              + Q +  I   + +  +L+ + Q ++ E+K   +   K L   +E   +E     +L 
Sbjct: 1813 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1872

Query: 994  HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
            H ++      EEL        E +  L+  EQ++E L   A +I+  +       S +E 
Sbjct: 1873 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1926

Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
             I         T S NR  +       +K D       A    ++  L       +    
Sbjct: 1927 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1984

Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
                   ++  L+++Y  Y D    L   LQ  +   +   S         LQ +L + +
Sbjct: 1985 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2044

Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
             ++ +  ++    E +    E  +          NDI+K       D +  R  +L  ++
Sbjct: 2045 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2099

Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
            N R E L+  L   L V+              S L     +PL+  A+Q       D I 
Sbjct: 2100 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2152

Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
            +++   QD   +Q  I N + E     ++   P    ++Q  +     +F   +H+    
Sbjct: 2153 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2211

Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
                      V+  E+  + L+ FL +    L    +  + VT+LS    +   E     
Sbjct: 2212 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2271

Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
            K+ E    L+K+ + H    DK L +     L   FK+ E      +   TSC+  LDAF
Sbjct: 2272 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2331

Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
             + +     +   +E T++  +++   F   +L K+++D +    K  LK P +  V + 
Sbjct: 2332 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2388

Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
              SL  L   +    +    ++             N+   + +    ++ +   +    +
Sbjct: 2389 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2448

Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
            E+   L+ + + +    L  L++ Q   S +   +QK     +         + +    +
Sbjct: 2449 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2508

Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
            +E  K    E  + V+K+ ++   L   L +     E P  K+    +D +W ++N+ T 
Sbjct: 2509 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568

Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
            D  + L  +     +   ++  + +W  EK L    L  L+  D   L  + Q  +    
Sbjct: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2627

Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
            EF+ R  + + L  + +  L     + S+   ++     +T + +  +L+G  ++  + +
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2685

Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
            DQA  +    +SLL++LS          S SL + T                +EIQQ+  
Sbjct: 2686 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2745

Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
            Q K +  L E+    +  E   +EL +Q E +   F   +   ++H   L          
Sbjct: 2746 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2805

Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
                ++F  W    K    +    S     +E  ++   DF  TL  ++   ++  +  +
Sbjct: 2806 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865

Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
            ++      +    L   L   +   +      + R  +L++SL++ L+ ++    L  W+
Sbjct: 2866 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2925

Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
                N  E+ K   +P  GE +    ++L ++ +Q F  V  LNN+           KE 
Sbjct: 2926 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2985

Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
               E + +I +   + ++  +            ++  E+ +E K                
Sbjct: 2986 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3045

Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
                       +L T+ +S   L H V    K + + L+V          E    K    
Sbjct: 3046 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3094

Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
            +LL+ E  A+  + + Q    +   ++  L  I +  +    + S +    ++L      
Sbjct: 3095 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3154

Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
              + E   + KE ++  L +L+       AL           K+     + + DL  + +
Sbjct: 3155 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3207

Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
            +L++   Q N LL+  +  +  E+    IK L E  S L++    +Q  +    EH+  Q
Sbjct: 3208 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3261

Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
              V     T++     F  F  + +      E LQ  Q+  N L            L +S
Sbjct: 3262 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3306

Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
              ++TS+ G +   DD+ +  +   K +  R A  ++ +  C      L S+L     TE
Sbjct: 3307 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3366

Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
            +     L   +K  +++   V+   QE   +++L +D     E+ K    ++A + +   
Sbjct: 3367 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421

Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
             + +  Q S+ ++  E  +N  E +N+ LE  +++           NE L  IEK     
Sbjct: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481

Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
            E        LE+    +K     ++ HN        IG S + L +     +   K   S
Sbjct: 3482 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3541

Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
            Q   + + QE   +    ++  L + +      ++ + +L+++   ++ +  +  S   L
Sbjct: 3542 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3600

Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
               W+  S   V   D  L +  + Q L +G E ++Q        IQ K       Y + 
Sbjct: 3601 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3657

Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
            T L   V  T     +Q   L  RL S  E            +++   +   VLKG    
Sbjct: 3658 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3710

Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
            QA+++ K +  E K  K L D +N +         W   E L  + AE+    ++    I
Sbjct: 3711 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3770

Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
              K++E                  + W      +L     I L  D   +Q++  K    
Sbjct: 3771 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3830

Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
             IL  +  ++ L +     + + +  E   +   L+ +   Y  +   +++R  QLE   
Sbjct: 3831 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3890

Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
               + F+    +    + E+++ II ++   A E E      TL   Q+E +++   I+ 
Sbjct: 3891 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3943

Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
            H   +  + +      EL+  E   ++++        ++I+  ++     ++  I    Q
Sbjct: 3944 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 4003

Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
            FH+K   + E   S++R    L Q  +  +  E+  +K++++  K   + + KL+ +++ 
Sbjct: 4004 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4058

Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
            +            G + D S      +LDQ+        T V E+E +L + ++  + F 
Sbjct: 4059 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4118

Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
             +H      +   +    DL+   +   V+K    + E+ R     L + ++    L  E
Sbjct: 4119 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4178

Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
            +I    E    D    +K I ++       D L K  ++ + +L          QD L+ 
Sbjct: 4179 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4232

Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
                ++    +L     I  +++ ++ + +       EA+Q+Q+  E  + +A   ++K 
Sbjct: 4233 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4292

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
             EE  S+   V+  L E + +   L   I  R + L  A   L +++ A+   +  +T  
Sbjct: 4293 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4350

Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
            E ++   +  VG   +++E+ L K   L++ V   Q   E +          S+ E    
Sbjct: 4351 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4409

Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
            LQ  L+ L  +   + E  + ++ + +  L   K +    ED+   L+  E  L   + +
Sbjct: 4410 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4469

Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
              LP + +E L   +E   A  +   + K  + K +Q+L     RC ++    + + ++ 
Sbjct: 4470 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4525

Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
            L EKW S+     E +   EE                 W   +E+      R ++ILD +
Sbjct: 4526 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4585

Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
              ++ E  +   +  +  E++ EL      L    Q  + V  + LL+++  +  + +Q 
Sbjct: 4586 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4645

Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
            + E   +++           A+ ++    E   K L    ++  + + ++T++ +   F 
Sbjct: 4646 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4705

Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
            K + A  + +  T  + +++  +     D+ +  +   EL              Q+ L++
Sbjct: 4706 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4765

Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
              L      + L+     +Y + P   E Q      +    L D  +    E+ K + S 
Sbjct: 4766 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4825

Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
             A++R   E+  G  +    V+  +Q+ S   E    +       L+    +  E  S V
Sbjct: 4826 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4885

Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
              ++E         +  G   +  D L     Q+++  ++ E + ++LNKAT   +    
Sbjct: 4886 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4945

Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
              + D + + + WI      +      + L     H   +  AL     K  LL ++   
Sbjct: 4946 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 5000

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
            L+       TD+  + I +   +V AL    Q  ME + + Q   D V
Sbjct: 5001 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047



 Score =  155 bits (392), Expect = 1e-36
 Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)

Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
            +L  L+S+  ++L +  ++  FS     +++       Q  Q+ +++ +   +E   Y +
Sbjct: 1048 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1107

Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
             ++++     N      +  D+ + QI    +   L E   R++ Q+   K++  L    
Sbjct: 1108 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1159

Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
                        KDD+ ++  +C++   +   +S+   +   LN +L++           
Sbjct: 1160 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1207

Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
            +   + +  + V ++TQ + A+ KL E     +++ +    + +  ++  +  ++  DE+
Sbjct: 1208 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1265

Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
            +       +ELQ      D M +  +  +++  +     K+ A + +E+ + ++      
Sbjct: 1266 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1316

Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
                        +DN L+ L  + K+ +          +++  VE++ + +   +E+   
Sbjct: 1317 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1362

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
                  T L++ K  ++ IE ++  +   +   E  S  V D +      + +++SQ K 
Sbjct: 1363 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1422

Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
                   +     I +++      Y    TLM +      D+   L+++++ L+   K  
Sbjct: 1423 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1482

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
             E+A          +LQ      S     AE   K  +  K+K + E+     ++  E L
Sbjct: 1483 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1532

Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
            + + L       K   + RN++++ +         L  S  LL  + L Q+++ + + D 
Sbjct: 1533 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1584

Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
            +   ++ V    +E K+K+      LT  E   + +    +     + + K   + ++L+
Sbjct: 1585 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1644

Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
              ++  +   A + K          + + QE + LI    E    EA++K   + L+A Q
Sbjct: 1645 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1700

Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
             + +E+D  ++T ++E T         E++    QL+  K +   +  ++ N   + E  
Sbjct: 1701 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1750

Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
                +Q  E+     +E D           N  LL  +V+  V     NL  +   +K  
Sbjct: 1751 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1810

Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
              +++   +       +       Q Q    E++++L++ +K+L    E      AL   
Sbjct: 1811 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1865

Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
             + + L      E+     D +     L  Q   Q +E  +   D+I   + KL   K+F
Sbjct: 1866 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1923

Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
             +           + + + D  Y  +  N VLE +         ++D      +++  L 
Sbjct: 1924 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973

Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
            H  ++ +S   +  ++   +K + ++  + E     + A + + +A TA +   E  + +
Sbjct: 1974 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 2032

Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
              +++ +L E + LQ Q+++       +     VL DA  +L   K  + + ++ I    
Sbjct: 2033 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2088

Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
                     VG  E+  +    + E+L+ T+     +QD L E L  + + E+ L+ Q  
Sbjct: 2089 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139

Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
                   LQ+++SKN  +++    +++      E  K + +  +    ++L      L  
Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199

Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
              S     ++E L ++E+ K  V    +  E   KL+  L       TE D  G  + ++
Sbjct: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2256

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
               + E     LE  K  E+    LK+     S  +  + A++L+   NL ++  E+  T
Sbjct: 2257 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2313

Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
                KEA T+          CQ  E ++  Q+L+  L   I+            + VP  
Sbjct: 2314 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2352

Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
            Q     ++   K L+  +K +E    +  E        I+L N     TT  + +A    
Sbjct: 2353 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2411

Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
                   +     +E+F        KG  + +  M  +   Y ++  ++    AE+ +++
Sbjct: 2412 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2466

Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
             + +KA E+        +K++    K   + A     E +   +   +    +  +N+ K
Sbjct: 2467 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2525

Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
             QE++ K+ + L+          W   L E+DS+ Q++ +   D  Q  E   N +  FQ
Sbjct: 2526 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2585

Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
                Q +Q     E   S              Q  +  + ++E++      E        
Sbjct: 2586 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645

Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
            +L+ P +  SLR                    LS     +  A+  S Q  +LL S+   
Sbjct: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
            L DL     +     +  +  NQ     QK+ + + Q        Q + +D+ A+  E  
Sbjct: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765

Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
               +   +++ IL S +  +   E H++H +    +    ++   +  ++    +  Q  
Sbjct: 2766 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2825

Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
              P+            + +LE++ ++  +  K +  Q++ +++ I   + +L        
Sbjct: 2826 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2868

Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
            L+    ++A    +L  ++   +   KQ+    N+ KE L   +  K  V  L   + + 
Sbjct: 2869 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2928

Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
            Q  +E  +     +E E  +A+  + ++++           N   S+  +  +++EV   
Sbjct: 2929 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2988

Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
              KS     D   E+         ++ +  K+ +E   S  S   +Q A  ++   D+  
Sbjct: 2989 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3046

Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
            +Q  +   L   Q  + SL+  + +      +  D  +++SD++G  +   +VE    E 
Sbjct: 3047 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3106

Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
            + +      + + LE  LQ      N   E  +  A+               + L++Q  
Sbjct: 3107 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3166

Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
              +A L ++E  +A      +TCK     ++   D    + + EALS +    L   +  
Sbjct: 3167 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3226

Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
             E+V+     L+E +S+ +  +IL + +E EH+E+  PV + E E+I     Q +  K F
Sbjct: 3227 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3281

Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
            Q++++  L+  +Q  +++    I+  AK    Q  +HD D       T  +  A   A  
Sbjct: 3282 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3341

Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
             E         D  +S+LS        W     EL +  K P                L 
Sbjct: 3342 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3393

Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
            +L++ + ST                    + IL  +++ + R+     + +T   QLE +
Sbjct: 3394 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3453

Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
               A           E    ++K+L       +Q  S +EE +   +   +D      H 
Sbjct: 3454 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3511

Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
                     L+ A+S   G  LK ++   E+ +++    D  QV     Q  +  RS+ L
Sbjct: 3512 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3559

Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
            +  L   + +  +   L + L +    L + S+ + S + + +Q  +      ++   + 
Sbjct: 3560 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3619

Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
             V +    G  L L      EV  ++D L++    ++ARY +++  S  V ++ + AL  
Sbjct: 3620 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3674

Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
               L    E     L K+  E L++   +  K + A QAQ+         +N+K     L
Sbjct: 3675 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733

Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
              V+  LL      +++P         W  +    K++ E + +  +   ++ QK EE D
Sbjct: 3734 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778

Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
               A++ +  +   +    +S + ETE++L+         ++ S   Q+++    +  R 
Sbjct: 3779 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3835

Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
               +++    G +++ + S  E +    KL+      +    +N +   +L R Q+L+  
Sbjct: 3836 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3895

Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
               +    ++L  WL  +Q  ++     +L    + +T+R       +  + + E     
Sbjct: 3896 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3948

Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
              +   G QLL L   +  +++      +  ++ +   +      L +   +       I
Sbjct: 3949 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 4008

Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
             +++  +  +  +     S+ +     ++K  + ++K   ++M+  Q + + + Q   ++
Sbjct: 4009 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
                  +  D+ +K  +     + L +M   W  +H ++  +   L  ++E   +     
Sbjct: 4067 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4121

Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
              L   ++  ++ ++ L+ P    SV K     Q+    +  +   L E     + L S 
Sbjct: 4122 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4178

Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
             +    +         IDEL     S+      ++++L+ +MQ+ +Q       ++D V+
Sbjct: 4179 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4238

Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
            +   +    +    P+   LET++ Q+E L+  + EA   +   E+L      L  K   
Sbjct: 4239 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4294

Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
             S    +++        W  + + I ++  K +  L     + +A  E  A L   E   
Sbjct: 4295 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4354

Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
             +   +   G+  A  +  A   +  LQ+DV   Q T EA  +  + L       E+S  
Sbjct: 4355 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4409

Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
              L   L  L QR   + +    +  + +  L Q K F   +E L+  +   E +L    
Sbjct: 4410 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4467

Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
                L +  KE  +  +    A  A+    + L     ++  + P S      + + N+ 
Sbjct: 4468 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4527

Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
             +W        ER ++L+  + L  +F    + +I  L + E+ L V    S P L+   
Sbjct: 4528 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4584

Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
              +++ E +V  N+   +S+  Q ++L  T T ++  ++ + +     L      RW+  
Sbjct: 4585 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4642

Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
            VQ + +R   +D   ++ + F  +   L  +L ++   L S ++        +T+   H+
Sbjct: 4643 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4702

Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
               K +    + +    T   G  L   T L      +   +S+L+D W  +  +  E  
Sbjct: 4703 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760

Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
             + +  +    Q    ++ L   L  ++ Q  +  P +H D+     LI   K  ++ L 
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4819

Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
              T +++ L+    +L      +D   +K Q++ L  +WE +C     ++  +E  L   
Sbjct: 4820 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4878

Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
              F+     L  WL + E       VL   + ++  +I++  K+ M+++        +  
Sbjct: 4879 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4937

Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
             MGD ++   +      I   +  I  R++ +        ++L    A +    + +  L
Sbjct: 4938 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4997

Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
              WL   E+ L+   K V+    + +E++  +AE Q    ++ +    V+ V        
Sbjct: 4998 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5055

Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
             D  +                           ++T+ ++       L  +W+ +  +++E
Sbjct: 5056 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5115

Query: 6127 RRMKIEE 6133
            RR K+ +
Sbjct: 5116 RRRKLND 5122



 Score =  146 bits (369), Expect = 6e-34
 Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)

Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
            P+  +AM P++ F++     P  +E++     +E+ Y   +    E +   + ++  H+L
Sbjct: 967  PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 1022

Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
             N   RI  S+ +S +       Q  L++LQ    +     +E ++ S     +LE  VN
Sbjct: 1023 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1082

Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
              K+ +    ++ LK  ERE Q              +  R+E+ E  L  ++  P+E+  
Sbjct: 1083 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1138

Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
            L         H+     F + + +++ + L  ++D +     I N+ EE  +        
Sbjct: 1139 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1183

Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
              L +  N++L+   Q   M+       D LK +   L + + A+   +   T L   + 
Sbjct: 1184 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240

Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
             +A +N +     T+K    E+       H ++D   KAK +     K  K  D+ F   
Sbjct: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300

Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
            +   D   E   N+      +L +  G G   ++  +    L+  I +     + IQ+ Q
Sbjct: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360

Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
             + SK      T+    +++K L+  ++    + +E +++ ++ + ++   KD   +T+ 
Sbjct: 1361 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1411

Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
             +     ++    K+ V     Q    L +++++ + ++  T L+      +  Q     
Sbjct: 1412 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1461

Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
             ++LK+   E + ++EE  EH+E   ++ +   N+   L   +   +PPF K+       
Sbjct: 1462 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1515

Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
                +E+     E L  AL            I  +  K   KM     T+E+R  L++++
Sbjct: 1516 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1558

Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
            + + E     FS  + ++Q    S ++ +E +++             I + +   +  L 
Sbjct: 1559 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1618

Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
            G      +   T EL+    +  +  K   G  ++L + +  +++   E   KL +  + 
Sbjct: 1619 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1678

Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
            +++QK    L E +I C  L  +  + KK+ + V      +++       +L   + K  
Sbjct: 1679 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1734

Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
            N  DW SN+  + +                F+  + K ++ ++ +   + L         
Sbjct: 1735 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1794

Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
             T E  N + ++V    + ++   +  +      +++    GQ    E+ E + Q   KE
Sbjct: 1795 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1853

Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
            L+                  SLQ+ L   D D+     WL   E++ + +E   +     
Sbjct: 1854 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1913

Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
               L R++   E V      L+    +    +    +C                      
Sbjct: 1914 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973

Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
               DR+++L  + + +    K L  + Q + D                       +A D 
Sbjct: 1974 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2033

Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
             +  ++++E+  +      +    E+++K  E++L     DAR   +  + +      +Q
Sbjct: 2034 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2082

Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
            KTL DI  ++++   L+ +     EKL +   + L  ++ L  ML     +E   K++  
Sbjct: 2083 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139

Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
              L        A   I  K +   QD+       +S  N + E  K    + +P      
Sbjct: 2140 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2185

Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
               SL  +++D          +H      + +L T +   +N S++  +F +     +  
Sbjct: 2186 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2245

Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
                   V E  Q +QE  +        L+ + +L K +  +     + ++ +   +L  
Sbjct: 2246 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2305

Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
            K K++E+ +   K+ +  C         ++KS +S  K+    +P  +      D+ +S 
Sbjct: 2306 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2365

Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
            +++   +KL+E W     EI K                    A+    S    LN + + 
Sbjct: 2366 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2422

Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
             NTE+          ++ + ++ +   +L  +L+++  E   KL    +A++ +   ++ 
Sbjct: 2423 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2482

Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
             + +NKT T         +         +A+ T +++NK               + E+ +
Sbjct: 2483 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2519

Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
            K  +   + LK    D +T L +         + K  L  +  KW+ L+    D  +KL 
Sbjct: 2520 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2575

Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
            ES     +       Q ++ +  Q +VE +   +++  +      L  Q+Q +Q+ L+  
Sbjct: 2576 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2629

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
              R             Q T  G  +L    E           +  +++ +  + ++W++L
Sbjct: 2630 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2674

Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
                 +  + I +  +++   +++L +      +L  +L+ S+ +   PD +  Q+   +
Sbjct: 2675 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2734

Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
                 I   ++ +   ++L E++   V     Y  ++L+  LE +   ++ +  K+    
Sbjct: 2735 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2792

Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
            Q L+        F  + R FQ  +   +            E + K H ++     LE+  
Sbjct: 2793 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2840

Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
            K+ ++    ++  +H+ E T     N+  +    E+  L+ QL  +K   +   + ++  
Sbjct: 2841 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2900

Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
             N+++  ++   ++ E+   L    D  Q N  E+    +  +G              ++
Sbjct: 2901 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2960

Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
             + + + L      +L V ++ K            ++D +  Q+  K+  LE   ++   
Sbjct: 2961 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 3020

Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
            F+E  +  K Q   +K   +D+     ++       +  ++++ + Q L  +++ AK L 
Sbjct: 3021 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3079

Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
             +++ + +++K   D      +LQ++  A+E+  L + +      L  K     + Q+ +
Sbjct: 3080 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3134

Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
                    +   +L     +  + + +Q +K+  +AF +++ A M S        K    
Sbjct: 3135 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3194

Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
                + D+    R+ E L  Q N  +D               L + Y  L  +   + +A
Sbjct: 3195 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3254

Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
             E   S      P  ++     + L M  + ++EE+E      QD+     G+I S    
Sbjct: 3255 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3310

Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
               Q    +L   N+  K   K     A +  E      + ++ + + LS M    E V 
Sbjct: 3311 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3370

Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
             Q   S    ++    ++++ K L   L   K  +  +++    +       D + +LK 
Sbjct: 3371 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3428

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
            +S L  +W +LL  A+      E +    +   E +E     L  +++ L   E   T+ 
Sbjct: 3429 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3488

Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
            +   E++++   L D +  + +++ +      + + +   + +  E    V++   F ++
Sbjct: 3489 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3543

Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
              +     ++ +K     EL+Q  +     F ++ + L N+  +       ++ QD+  +
Sbjct: 3544 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598

Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
               +Q  EL+ + +   L  +N+ + L      +      E   I+ ++E  +   +DI 
Sbjct: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3657

Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
             K+S +V K+   +  + R++    EE+   L  VE  L        K +   +AQ   K
Sbjct: 3658 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3717

Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
            ++  E     + L+ L+     ++E  P +A+E ++ ++    ++Y+ VS     +  ++
Sbjct: 3718 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3777

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            + A ++ +++     +  +WI  T   L +  D      L    ++ Q+ ++ +     L
Sbjct: 3778 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3833

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
             H   +           D+L +S  ++    +  + Q + + L ++ +  D +  I SE 
Sbjct: 3834 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3882

Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
                                    +   +  +S++    L  E      EEH +  E+I 
Sbjct: 3883 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3942

Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
            E   +I  M KT  +++        P  G      +   + L   IK  E+V +++   L
Sbjct: 3943 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3994

Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
               I Q+ ++ ++I+ + +         SLE +  ++  + P +  E+E++++QI     
Sbjct: 3995 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4040

Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
              +++ VD++  +  L++ LKQ  E
Sbjct: 4041 ENKNVSVDME-KLQPLYETLKQRGE 4064



 Score = 88.6 bits (218), Expect = 2e-16
 Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)

Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
            ++LS   G+ +QE++   + L              L+  I ++ +    I  +   + +I
Sbjct: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018

Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
              +    P++ A        +   K   + ++K+   YE  K+  +EM A S    KD  
Sbjct: 4019 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4078

Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
             K V  +    V +WEN   LV E   +   V+EL +++  +  S++ T+   ++ +  L
Sbjct: 4079 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4138

Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
            +   +    +K++    E ++EE +   E +D +  +   L   +      ++P  +K  
Sbjct: 4139 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4195

Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
            + +   W  +N+  +D  + L  A+    +  +    + +W + A  K+        D E
Sbjct: 4196 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4255

Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
             +K++++  +Q  SE  ++  E++ L   +E+ L+    ES        L +++ +   L
Sbjct: 4256 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4315

Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
                 +  H L G   +  + +  LD+    +  TE LL    P        ++E  +  
Sbjct: 4316 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4375

Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
            +LQ              K    L+E+  G     L  +L  L +++++V +    +K  L
Sbjct: 4376 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435

Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
                  +K  + + ++   W ++ + +L   K      ET K  EQ    +      E +
Sbjct: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4493

Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
                K +    + +    PK+    +   +   + + E +E+    R  +LE++L   + 
Sbjct: 4494 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4553

Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
              +  ++   WLT  E+       P           ++ ++F   +   REQ   + +  
Sbjct: 4554 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4613

Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
              LK   F++++++++    L+    R++ ++++L E            + F++    ++
Sbjct: 4614 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4671

Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
             W++E ++SL      + ++ +     KIK  +    E    +    ++      +   L
Sbjct: 4672 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725

Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
             +KT            L+++ ++WD     +    +  E+ LL   ++  + + L   L 
Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4785

Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
             ++ +      +   +      +  +K F K+    TS ++ LK     L+E ++ + S+
Sbjct: 4786 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4845

Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
             +    E+    E++          L+  +R+ + +   V  L   L    +        
Sbjct: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905

Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
            P D+ A+   + + +E   +L  +   L K       +LA+       T      II+  
Sbjct: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965

Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
             + +    K  + RLAS      AKQE +E  L  +  ++ +   K K  +P   ++  +
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025

Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
             +       +E T++   V+K+ + ++
Sbjct: 5026 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5052



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)

Query: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            D+W+ I  + +  + K+++ L    Q    + A+  WL + E +L   +      DI  +
Sbjct: 4747 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4804

Query: 6590 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6649
               +   +   K      + V ++  S++E ++    +S+ ++ ++++LS  WE      
Sbjct: 4805 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4864

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6708
             S +  L  +L Q ++FH +   LL WLA A+   R    + D +   R L++  +E M 
Sbjct: 4865 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4923

Query: 6709 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              K+L E++ +++    + +++L   H +     +  + +I  + +++
Sbjct: 4924 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4969



 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)

Query: 6548 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6604
            K+++ +Q   Q    + A+  W+     +L    M+   +D++ ++ +++ L++      
Sbjct: 4215 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4272

Query: 6605 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6662
              +  +  +N  ++  L+  TE  +   +Q  L +L L+W++ +  + + +  L  +L+ 
Sbjct: 4273 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332

Query: 6663 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6720
               F      LL WL   +     QK    DPKA    L +       L+ +++  Q  V
Sbjct: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4388

Query: 6721 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6774
            + + +  N L+    GE+    + K+ V+ ++ + + E+  Q    L G    A
Sbjct: 4389 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4442



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 56/276 (20%), Positives = 107/276 (38%), Gaps = 24/276 (8%)

Query: 6504 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 6550
            K G  VLNG     N ++   + GL  I +  +     +E +      +  EL+ KL   
Sbjct: 2410 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2467

Query: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 6610
              LQ+   + SA+  WL+K        +    P+D + ++ +V++ +            V
Sbjct: 2468 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2526

Query: 6611 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
              +     E L+   ++PE+   +  L ++   W+         +  L +S      F  
Sbjct: 2527 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2586

Query: 6669 LSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEIS 6727
            +   L  WL     +     V  P   DP  L   R+++  L +E   R+PQ + L    
Sbjct: 2587 VEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2643

Query: 6728 NSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 6761
              +L +   +  +    +E++  + +K   L  Q+S
Sbjct: 2644 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2679



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)

Query: 585  LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
            L  W T+ E L    +    + K  EI+      L    L H +    +N+AGN L+E S
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402

Query: 640  NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
                 S++  +L  LN+RW+ ++ KT+         +KQ           L    +    
Sbjct: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4444

Query: 700  FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
            F  ++     E+  Q +   E+H   ++   G  + AK  E+L   +E+  A EAK    
Sbjct: 4445 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4493

Query: 759  QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
                    EE+ K L+ KG  M       +E  +  DI N+  +E ++ V     + K+ 
Sbjct: 4494 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4538

Query: 818  EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
            E K K++                   L++ ++   S ++  +++ +A+Q L     P  +
Sbjct: 4539 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581

Query: 878  -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
                   I +HK     + S+ + + +  K    LK    +   + ++     V ++WE 
Sbjct: 4582 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4641

Query: 929  LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
            +       VQ+L   +E+G+  D+  K  KQ ++   KL+       K L  E E     
Sbjct: 4642 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4691

Query: 986  EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
            +    QL  H E  + L  +     +     R LK+
Sbjct: 4692 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4727



 Score = 43.9 bits (102), Expect = 0.006
 Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)

Query: 6541 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6600
            Q L +        QQ++ D  A   WL   + E           D+  +E  +K  ++  
Sbjct: 2793 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2847

Query: 6601 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6658
            K   T ++ +    ++  E   L+T+  E   LQ +L  +   W+     V      L++
Sbjct: 2848 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2906

Query: 6659 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6718
            SL +   + +  + L  W+   +N  ++        DP        +L  L+KE+ +   
Sbjct: 2907 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2963

Query: 6719 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6778
             V++L   +NSLL     +  +  +E   +I+ K+  + EQ+      L   +N      
Sbjct: 2964 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 3019

Query: 6779 SFDEV 6783
             F EV
Sbjct: 3020 EFQEV 3024



 Score = 41.6 bits (96), Expect = 0.028
 Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
            W+ ++ + ++ + K++  L    Q    +  +  WL  TE    +L   KP   D + IE
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4368

Query: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
            + + +   +      +++ V +VN +  + +++ +  E++ LQ++L  L+  W+      
Sbjct: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
            +  +  L  +L Q + FH   ++L  WL   +      H+   K     L E  +E + +
Sbjct: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4482

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6755
              E+       +  +E   SL+ KG                +D    +EK   +E KL +
Sbjct: 4483 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539

Query: 6756 LREQVSQDL 6764
             + ++ + L
Sbjct: 4540 RKTKLEEAL 4548



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 17/259 (6%)

Query: 6554 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6611
            QQ +    A  +W+ +TE +L  L   +   D    +L+V++    EIL+  D    LV 
Sbjct: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3844

Query: 6612 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6671
            S     K        E   ++ +L ++   ++            L ++      F +  +
Sbjct: 3845 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901

Query: 6672 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
             L  WL   ++    + +  P  +   L + + E  QL + + E +P +D + +    LL
Sbjct: 3902 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3959

Query: 6732 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL-----QGTQ---NPASPLPSFDE- 6782
                GE     +EK    +    Q++E V +  +AL     Q TQ        L S +  
Sbjct: 3960 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018

Query: 6783 VDSGDQPPATSVPAPRAKQ 6801
            V+   QPP+ S    + K+
Sbjct: 4019 VERLRQPPSISAEVEKIKE 4037



 Score = 37.0 bits (84), Expect = 0.68
 Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)

Query: 6535 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6587
            W +   ++ H++ ++ Q    N +    D   +  WL +   +L  L +    ++    Q
Sbjct: 3544 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3603

Query: 6588 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6647
            + ELRV +   +L+  +  +AL+  + +      QT   E   +Q +L  +   ++    
Sbjct: 3604 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3659

Query: 6648 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6707
                    L Q+L   +  H   + L  WL   +           K +  +  + R +  
Sbjct: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3717

Query: 6708 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6760
            +L+KE    +  +D L E+S++LL        +G  +   E  E+  ++   + Q  E++
Sbjct: 3718 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3777

Query: 6761 SQDLMALQ 6768
               ++  Q
Sbjct: 3778 DAAILRSQ 3785



 Score = 36.2 bits (82), Expect = 1.2
 Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)

Query: 310  KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
            K+++++L K  +++ Y ++       ME  N + +  L  ++ + D   +    ++L+  
Sbjct: 4258 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4311

Query: 370  WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
            WD L+ +I   + KL  AL         L +  AWL   E L+ E      D  +A+ + 
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4370

Query: 423  ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
                  +Q  +   +S ++      N L+     +E ++L     NKLE + +R  N+LE
Sbjct: 4371 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4426

Query: 476  K 476
            K
Sbjct: 4427 K 4427



 Score = 35.8 bits (81), Expect = 1.5
 Identities = 33/191 (17%), Positives = 88/191 (46%), Gaps = 18/191 (9%)

Query: 6549 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 6605
            + QNL  +++N   +  +  W+ + + +L+  +     SD+  +E  ++  + + +A + 
Sbjct: 634  LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 690

Query: 6606 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQD 6665
            +++ +    +S    +Q  +P       +L +L    E+    + +      + L    +
Sbjct: 691  FESSLKEAKISE---IQMTAPLKLTYAEKLHRL----ESQYAKLLNTSRNQERHLDTLHN 743

Query: 6666 FHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLEKELVERQPQVDMLQ 6724
            F   + N L+WL    N +++  V    ++    +  +++   +L +EL +++  +  +Q
Sbjct: 744  FVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQ 799

Query: 6725 EISNSLLIKGH 6735
            EI+  LL++ H
Sbjct: 800  EIAEQLLLENH 810



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)

Query: 6624 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6683
            +S  +  L+  L  ++  W+     V      L+++L+ C  F    ++LL W+   +  
Sbjct: 3309 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3366

Query: 6684 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6743
               A+   P A+ + +    +E   L++ L +R+  V++++     +       D ++  
Sbjct: 3367 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3426

Query: 6744 EKVHVIEKKLKQLREQVSQDLMALQG 6769
            +++ +++ + + L  +       L+G
Sbjct: 3427 KQLSLLDSRWEALLNKAETRNRQLEG 3452


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  234 bits (596), Expect = 3e-60
 Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)

Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
            +N I + + S     K  LPG  +Q  S++Q       E +QES       + +LE++  
Sbjct: 1161 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1220

Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
            + K    E+  S +                 N +  ++N ED R + +++  PLE D + 
Sbjct: 1221 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1278

Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
             +  ++ E EKL  +LE  K  +  +     E  ++    +          +VL N+   
Sbjct: 1279 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1338

Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
               S+ ++D L    + LK N ++   +++ ++  L   E    A++ DK +++      
Sbjct: 1339 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1387

Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
               +  +K++ + +++++     L+ + +       +M K   E  +          QL 
Sbjct: 1388 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1446

Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
              W+ V  QI  +      + +     +   +DT   L    Q ++   +  +E     S
Sbjct: 1447 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1502

Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
               L T L   K   S      E++MK+   ++ +K  E     +K             +
Sbjct: 1503 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1555

Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
            +Q K    R +M+ +         +L      L   +    +  K   D +   ++  +S
Sbjct: 1556 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1612

Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
            L EE K+ V      +   S+++ TL+D     +    K    S+++  K E+ S     
Sbjct: 1613 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1672

Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
            I+ F                      +QES  L+    + +++ + T  ++K     +  
Sbjct: 1673 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1732

Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
             Q+E +E   GI   L +  N    +   E   + D   +LK  + +   +Q+ +Q +  
Sbjct: 1733 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1790

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
             +   +K    F      L+E  + + Q ++ L+ Q++N+  +K E  NLK        D
Sbjct: 1791 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1844

Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
            ++  TAIK        + Q+ + K   + + L+W  S +D+   +   K K++   I+Q 
Sbjct: 1845 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1899

Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
             T F+E  GK         AI  + +    ++    D    + + N   L+Q+ +K K  
Sbjct: 1900 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1948

Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
             ++II   ++++    + +  ++L  K    L+ EE +KL K ++ + +  E +  E ++
Sbjct: 1949 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 2005

Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
            K     + Q++LE       + +  LQQ    L NLE     I  +  +    ++F E V
Sbjct: 2006 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 2065

Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
             +    ++ +T    +              + + S+   +V+ KL    D    L +  +
Sbjct: 2066 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 2125

Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
            +  N L D  +    Y++A    +  + + EA     +  P  VD  N +  LE     Q
Sbjct: 2126 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2185

Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
             ++ S    ++ L +   ++     S   AK  +Q TL ++V +   + ++   +  + +
Sbjct: 2186 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2245

Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
              L      +   +++   +  +E+ L +    +PL+     + + ++  L  ++   + 
Sbjct: 2246 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2304

Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
             +  + + ++        +    L   +  L  ++       KE     EELK + +   
Sbjct: 2305 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2361

Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
                    + +NL E+L    +TK  A TE         ELS+ + +   ++ E+ +  +
Sbjct: 2362 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2413

Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
            +L +LL +   S   +P     V      ++  ++ ++  ++   +++ KE V +  ++ 
Sbjct: 2414 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2466

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
             +F   + +LK++ ++TT     +      E   +  E+ + + +K  L    I +    
Sbjct: 2467 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2526

Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
             I    + + V  PA+  + V+     L       + +E  +N+ L S        S  Y
Sbjct: 2527 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2586

Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
                  ++ KI E+N  L  ++K  ++ S  ++  Q++ K    W               
Sbjct: 2587 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2646

Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
                     EL    +K+ EL  ++ +++E++P   +A  W   L     ++Q+++Q   
Sbjct: 2647 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2706

Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
             R  +L +++  + ++  +    + W+     +++   P   D    L+     VQ+ L+
Sbjct: 2707 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2765

Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
            +   +      +    +  LS   E   L   ++E    VT     +   L       D 
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2825

Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
             +   ++ +S+ + +S   + L +K     +   H       LE  + MK+ I       
Sbjct: 2826 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2878

Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  Q   K + V Q   + L  +   E +  E +  L+ ++K   + +++ EN  Q 
Sbjct: 2879 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2932

Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
            L +  A     + MS D    L   + E  +       L+   E L+ D K  +  L   
Sbjct: 2933 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2991

Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
             H+ ++      + L      E    +   +  K N       +   E +++ES  K+  
Sbjct: 2992 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 3051

Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
              E+ E     W  + K   ++EE +                +  +NS+A++    SL  
Sbjct: 3052 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 3094

Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
            E      +    N T        E D    +D    L  +V+      TE LH+ K  + 
Sbjct: 3095 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 3150

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
             +                    Q+  E Q         E+  +    L+  K+Q  + D+
Sbjct: 3151 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3182

Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
              +Q  +      L+T + +L+  K Q+ L ++ ++D    ++ ++S+ +    +    L
Sbjct: 3183 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3234

Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
             ++E+I  E    S+Q D ++   LE K      F   I    ++M+ Q+ + D++    
Sbjct: 3235 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3288

Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
                              ++P G++ +  Q     + + +K      +E  +++N     
Sbjct: 3289 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3325

Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
            +  M      T+ +L      LE L ++ + L  +    EE      K+L E +  L + 
Sbjct: 3326 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3384

Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
                  +L+    + E      +  ET+  +L    +   ++   L    + + W G+  
Sbjct: 3385 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3441

Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
                    +T  L    D++    +        R+  L+  L +   +Q+ ++ L   ++
Sbjct: 3442 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3501

Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
             ++  +  Q       + V  Q+Q+       L++ +S V  ++ EGE++        +V
Sbjct: 3502 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561

Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
              L+ +  LDS W  L      R  +L    V   Q    L+ + E +   +++L +   
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621

Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
                     +Q     AL+  I NH     + V+    ++  S++    ++Q++  F   
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3679

Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
            QV  ++I +EKS      LQ  L   + F E+   L   L  +   L  +S+ + + E L
Sbjct: 3680 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3738

Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
             ++ S  + ++ +I  +   + Q L  G +L+   +  E   ++ ++  ++ ++  + K 
Sbjct: 3739 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3798

Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
                   L+  L+     +   ++L  WL+  +  L  ++ Q L   +     +R     
Sbjct: 3799 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3855

Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
              E  KE     +L  ++  + + LL L        L   +A+  +++ ++   +    E
Sbjct: 3856 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3913

Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
            ++    +      +A    +SW+   E +      +      +  +  LQ  K F ME +
Sbjct: 3914 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3971

Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
             +K  I D V      ++ C  E K+  + +  + L           E   Q  R   ++
Sbjct: 3972 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 4031

Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
            N+  +  E+L   +TE+++ I    + L A     +TL Q+ E    +++L+ + +   +
Sbjct: 4032 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 4087

Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
            ++      L EL        ++ Y+  ++    + ED   R   +DE   + +    +++
Sbjct: 4088 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4147

Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
            Q+  S++ +++  +    +  EV  +  +    +  +K V + +E L+   E L+   +E
Sbjct: 4148 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4203

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
              +  G  +K               A+ +++K       W  ++  + ++  K   +++L
Sbjct: 4204 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4251

Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
             + +   H      +K  +   + L +  +  + + +    A + I+E    +Q+  +  
Sbjct: 4252 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4310

Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
            +   S L        +P    +   L     SL +A       LE+ +            
Sbjct: 4311 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4370

Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
             F++V      L+     G  LE++K  I   ++     +QQ+ E     LNH   L   
Sbjct: 4371 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4426

Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
               ++ + E S K  + D     L  +   W       + R  +L+G  L   +F +  +
Sbjct: 4427 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4479

Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
            + +  L   E  L         P+ +E +   + +L+ +V  +Q+  ++       L+++
Sbjct: 4480 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4539

Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
            +  E       +   L  RWQN ++   QRK  +DG +RQ + F   +E+L ++LTDT  
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599

Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
             L A K      L        E  N  +     F+ +  T    ++ G+++L       +
Sbjct: 4600 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4654

Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
             ++ + I+ L++ W+ +E +L E   + +  +    E  +  +  I  L    Q L   S
Sbjct: 4655 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4714

Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
               L  + + +  + +  K     + S  + + EL      L      +DV+++K  +  
Sbjct: 4715 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4772

Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
            +  +WE +  R+  R + ++D       F+E   +L  WL + E  +    +I+ +    
Sbjct: 4773 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4832

Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
            K Q    K+  + +           + G  L  K S      ++DD L+++ D+W  +  
Sbjct: 4833 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4892

Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
                R  KL+E   F  Q    +  L  WL R+E +L+  +PV  D+     +   +   
Sbjct: 4893 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4949

Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
            +  Q+++ + ++ V+++      L+  S       +   ++   + L  RW  +CA+S+ 
Sbjct: 4950 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 5004

Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
            ++ ++E   R  ++F        +WL  AE+T       P+  + L T     + + + F
Sbjct: 5005 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 5060

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
             +++ E+  +L         +      D+ + +K  +     R++ +        +RL  
Sbjct: 5061 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 5120

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
                    +   E++L WL   +  LT+ +        ++++ L      F +E+T    
Sbjct: 5121 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5180

Query: 6299 KIDQL 6303
             +D++
Sbjct: 5181 DVDKV 5185



 Score =  197 bits (500), Expect = 4e-49
 Identities = 113/266 (42%), Positives = 148/266 (55%), Gaps = 35/266 (13%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT WIN  L +      ++DL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 210 ERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 267

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +L+ R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 268 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 318

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  MSA++ LLLW Q+    Y  +   +F 
Sbjct: 319 -------DIHVTGESE----------------DMSAKERLLLWTQQATEGYAGIRCENFT 355

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           + WR+G  F AIIH  RPDLIDM +V  +SN  NL  AF +AE ++ + RLL+PEDVDV 
Sbjct: 356 TCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPEDVDVS 414

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE 293
            PDEKS++TYV+         P  GE
Sbjct: 415 SPDEKSVITYVSSLYDAFPKVPEGGE 440



 Score =  193 bits (490), Expect = 6e-48
 Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)

Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
            N  EE  N  FV   L+  D   +Q    ++ +    +   ++  ++  +A+E+F +SL+
Sbjct: 775  NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 834

Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
             AK+          S+ Q+     LT   K   +H ++       +  K+L+ S ++ ER
Sbjct: 835  EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 874

Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
              DT    +  A +  I L+E     V  +++E N  +      + EL++       NI+
Sbjct: 875  HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 934

Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
             VQ    ++ L++    +    +R     +   +L   +  ++H++E       F D +E
Sbjct: 935  SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 994

Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
             T               C  +  +    + LV E +E+   +L+      N      T+I
Sbjct: 995  ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 1053

Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
            Q     S   L+ S   K     R  EI I K++      N H     K   +       
Sbjct: 1054 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 1110

Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
            +     F  PP  KEA       +D+  + E  Y+N+   L LW +   N+K+V+  W  
Sbjct: 1111 MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 1158

Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
                    + + E DR R      +      E  + ++ +Q   +   E   E QV   S
Sbjct: 1159 --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1210

Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
             + ++E  V  C               +  ++L ++  +    ES+   L  S+   I  
Sbjct: 1211 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1255

Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
            +LE  + ++++Q  + +    L   +  +T E  +LKK+ E + D   T  +  ++ FS+
Sbjct: 1256 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1314

Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
               +          + +  N+ + +  S T                      K+K V+ V
Sbjct: 1315 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1355

Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
            LK+ +  + L K +  +L     ++  +  +E + S  +    E+++  Q    L+D+  
Sbjct: 1356 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1413

Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
             L+K     +E +K  +E     +   +   +  E++++V  Q++N L++  G  +  + 
Sbjct: 1414 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1472

Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
              +    +D    + +T  R++ E + E  K L T+      L  ++     E+K+S M 
Sbjct: 1473 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1526

Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
                E +   E+    +K+  L      A +++     + ++   S A L+ +   D+  
Sbjct: 1527 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1583

Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
            ++   + L + Y          L  +EK L E +K +++  ++L+  +      LK  ++
Sbjct: 1584 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1643

Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
            AG       +    ++   K+ L +A     L   L   G+ + +  +N    +   L+ 
Sbjct: 1644 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1701

Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
             +  L    L+QLQ+S  + D  V         +E+      + DL T  +N     +E 
Sbjct: 1702 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1761

Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
                D  V+    + K ++LQ+         G+ + +  + K+ +      G+K+ ++D 
Sbjct: 1762 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1814

Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
            K+L      +E +L  AK +   C    LK+++S ++         +K  T+ ++E T++
Sbjct: 1815 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1857

Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
             AAV++LEE         DW  N D   E A +K   +  Q          +S    EDE
Sbjct: 1858 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1917

Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
               N L+    ++D  +   Q E + + Y +++A+   I    Q   +  T++  ++L  
Sbjct: 1918 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1972

Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
             G   S +  + L + +  LK + E+           LA  E  MK   + +E L+    
Sbjct: 1973 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 2022

Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
            D   +   L + ++ + ++E   D +  L  K        E++ +H      +T    ++
Sbjct: 2023 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 2082

Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
            LE+     +    +V+     +++Q+K       +    +  N + +    L  + QH  
Sbjct: 2083 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 2142

Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
                 L   L++ E  A       +  D   LQ        L+GQ   Q   +   K+  
Sbjct: 2143 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2202

Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
                         K +++  ++++  ++E L     E   ++     +   +++ + E +
Sbjct: 2203 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2262

Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
             W  N+   L     +PL    +   I K  +    I  RQ S+ ++ E+VK  + +   
Sbjct: 2263 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2322

Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
               S L   ++DL  ++     K  +   ++E +L+ +   F  + +      E++T  +
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2381

Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
              V+    +            +E   H   LE     L+EI S G+ +   +   + E+ 
Sbjct: 2382 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2438

Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
            N   + F  +ED +K  K      Q  +      V+    + ++  +K   +Q       
Sbjct: 2439 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2498

Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
                 E+   +Q    L   E+    N G+   + NL   +T     I  V     V + 
Sbjct: 2499 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2556

Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
             G          N   + + +  T +    ++    L++KI +L+T   +  K Q    +
Sbjct: 2557 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2613

Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
              A+   ++KM +   K           A  +  E  +     L Q + K + L D++ +
Sbjct: 2614 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2673

Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
             L EN    ++ + K++L       E D  ++ L  + ++   K  +  N   + +T   
Sbjct: 2674 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2727

Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
             L Q  ++ +L   +L  ++++   +  ++   +   ++        + +TA    I  +
Sbjct: 2728 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2787

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
              E+ S    V+ +L         L   +  R + ++ A    T+Y+  +    + ++ L
Sbjct: 2788 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2847

Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
            +     ++ +    D  N  + LE   + ++E++     I   Q L E L       A +
Sbjct: 2848 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2899

Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
            + +Y   EL  +   + ++FK  E +AE ++++ +        +++M  D     + ++T
Sbjct: 2900 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2956

Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
               +   S P+S + + LE L     + SK L +     ++ + +   +  LL+ + +E 
Sbjct: 2957 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 3014

Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
              + L L  +   W+                     K+   +E    W   C+   +E K
Sbjct: 3015 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 3074

Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
            F  +  E E  I  L +LQ+E+ +                 + +  +   T+E   L+  
Sbjct: 3075 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 3134

Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
            +    E +  ++  L  + Q+ +  Q V + S      A E +     + S     +   
Sbjct: 3135 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3194

Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
            +LQ  QK+ + ++ ++       ++++   +  + T+     +    Q+H   S+Q +E 
Sbjct: 3195 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3254

Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
             S L+   +G   F+N + ++  +++E    +   A +    E  +K  E I   +   E
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3314

Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
             L +S   A     M    EE +  L     ++E + +Q +K +++AQ  ++++      
Sbjct: 3315 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3374

Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
            L+ ++SKL E    +Q   E +  Q    M+   I                P Q  QQ  
Sbjct: 3375 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3434

Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
                                             ++++   R +QL +A +    + D L+
Sbjct: 3435 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3494

Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
            S  +W+ +T  L+AN     A++  ++        +Q  L+D   + + +  I  + E +
Sbjct: 3495 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3551

Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
            +   E  +  + +++LS   ++  AL  K      Q++ ++         ++ + + ++ 
Sbjct: 3552 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3611

Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
            I+  L++ E         EE +   + + ++I    K + + VS    L++  +      
Sbjct: 3612 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3671

Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
            V  + +        ++  +  ++ELL+  +     + E+   L   LN    + S   + 
Sbjct: 3672 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3731

Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
                + L + Q E+  +++ IL   Q  +  L++    LK T  +    ++ + E + + 
Sbjct: 3732 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3790

Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
            R   +T     VA+      +L RR         ++L  VE E+     +   G+E  +A
Sbjct: 3791 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3850

Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
            +  P+      K++K + +     SS  +       +E   K+   DN   ++++   + 
Sbjct: 3851 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3910

Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
              E+     LR  Q ++            ++DA+       EK               + 
Sbjct: 3911 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3947

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            ++ L   Q +  ++       +Q+    +++  + ++ ++      ++  C ++      
Sbjct: 3948 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3994

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
                E +++  KL  V  N + +  +  E++ + +    L       ++E L P  L+E 
Sbjct: 3995 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 4048

Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
            +SI+++ P      +  RQ+  + +Q+ EL   E K  I        K  PQ  +    +
Sbjct: 4049 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 4103

Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
              + QE   +A    S  + DV       D  +S   Q  DK   +   L   + +L  P
Sbjct: 4104 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4163

Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
                   + ++ Q+S N  +   +      Y T ++                  K    +
Sbjct: 4164 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4223

Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
            L+ +     N+ T     E   ++   L +K +     L +T+      + + LE P + 
Sbjct: 4224 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4282

Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
                  QQ   ET+  E+  L   L    +   +L+ A   P  +  ++ +  D L    
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4340

Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
            +    A   R   L+  +     YQ+ ++ ++  +      + S + +   L  +  Q  
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4400

Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
              +  K++AY  ++E       AE  + K+ +E ++    + +   + +L+ + DS+   
Sbjct: 4401 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4456

Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
            +  R  +L    +   Q Q AL + +  L      + ++K   G  K  + ++A    ++
Sbjct: 4457 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4516

Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
            N  +  Q  V     A   LI++ SA    S LQN+     ++   V    EK+ Q   +
Sbjct: 4517 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4572

Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
            L   L++ + F      L++ L      L+++ P   L E  +E+L    + + ++    
Sbjct: 4573 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4628

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
              K       + +G+Q++A   CP+     ++  I  L+E+W S+  K++    +L+  L
Sbjct: 4629 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4686

Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
               + ++        WL  ++ TLN     SL     LDT+   I+    F+ EV   +S
Sbjct: 4687 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4739

Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
             +  +I +     HLK    + D   ++  L   + +W  ++ +L +    L   +    
Sbjct: 4740 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4799

Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
               +A ++++ W+   E + S +  +   +   ++K  L +HKEF+  +  K  + D  N
Sbjct: 4800 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4857

Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
            ++   L   +  S   +  +  + L E+  +W  + G    +   LE+ L    +  + +
Sbjct: 4858 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4915

Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
            Q L +WL   E +L   Q     I  V  L+ + +  + +L  ++ ++  LK+S   L  
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4975

Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
            G+     D +S +    Q+ S+    V  L  S Q+ L+      + +  V    + +  
Sbjct: 4976 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 5029

Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
             +  ++  +     L    + L++L D+ +      E+ +  + K   +  +V  I    
Sbjct: 5030 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 5088

Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
               T K W  + +A  +++       Q   A + A   A   L +    + Q A  +++ 
Sbjct: 5089 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 5148

Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
             +  E++P  ++++K L  + Q   E   +    +D++
Sbjct: 5149 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185



 Score =  183 bits (464), Expect = 6e-45
 Identities = 676/3660 (18%), Positives = 1402/3660 (38%), Gaps = 447/3660 (12%)

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
            +E L+   R+++E      +I ++      + + E +L  Q  ++  + ++   +  F+ 
Sbjct: 1227 QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ--IRTPLERDDLHESVFRI 1284

Query: 3350 QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPL-SYREALERLEQSKALVS 3408
             E E  +     K   ++++D+ T  +K E    Q+ +S  + + R  L  + Q+   V 
Sbjct: 1285 TEQEKLK-----KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339

Query: 3409 NLISTKEELMKLRQIL--------RLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEW 3460
            ++ ST  + +K   ++         L++L  T+   +C  + V A      +L+   K+W
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK---LCEEEAVIADKNNIENLISTLKQW 1396

Query: 3461 EMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGEN 3520
                +E +Q +  + +E+++   I D + +   E          +   E  D L +  +N
Sbjct: 1397 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE-----RDLDFDWHKEKADQLVERWQN 1451

Query: 3521 VEKQQLLLTLLLQRIRSIQNVPESSGAVETV--PAFQEITSMKERCNKLLQKVQKNKELV 3578
            V  Q      +  R+R ++ + +S         P    I  ++    K+ +   +N + +
Sbjct: 1452 VHVQ------IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1505

Query: 3579 QTEIQERHSFTKEIIALKN-------FFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKG 3631
             T++ ++     EI   ++       + +Q + + ++   Q    ++    + +S +K+ 
Sbjct: 1506 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1565

Query: 3632 K------LTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPS 3685
            +      L  +  M+ LR +Y+ + T++   I+   +  ++  E+  EK   E  K    
Sbjct: 1566 RMQSSADLIIQEFMD-LRTRYTALVTLMTQYIKFAGDSLKRLEEE--EKSLEEEKKEHVE 1622

Query: 3686 YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQ--- 3742
                 K +E+   + N+ K L+   K  +     QK   +E+     +L+E    +Q   
Sbjct: 1623 -----KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1677

Query: 3743 -----DIVEQDPGQAQEWMDNLMIPFQQY--QQVSQRAECRTSQLNKATVKM-----EEY 3790
                  + +++  + ++ +  L   +     + + Q  E +TS   K   K+     +EY
Sbjct: 1678 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEY 1737

Query: 3791 SDLLKSTEAWIENTSHLLANPADY----DSLRTLSHHASTVQMALEDSEQKHNLLHSIFM 3846
             + L+     +  T + L    +     D    L  + S  +   +D +     L  +  
Sbjct: 1738 KEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVK 1797

Query: 3847 DLEDL-----SIIFETDE--LTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESE- 3898
            + E+        + + D+  + Q + E   +   L  K  +S  ++ ++    +  E+E 
Sbjct: 1798 NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1857

Query: 3899 ---VKSMEKRVSKIKTIL--LSKEIFDFSPEEHLKHGEVILENIRPM-----KKTIAEIV 3948
               VK +E+  +KI+ +L  LS    D S     KH +VI +N         K  I E  
Sbjct: 1858 VAAVKQLEESKTKIENLLDWLSNVDKD-SERAGTKHKQVIEQNGTHFQEGDGKSAIGEED 1916

Query: 3949 SYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLEN--VTQEQNELL-----KVVIKQTNEW 4001
                 L       +     +  NQ  Q +K      ++Q Q  ++     +V++++  ++
Sbjct: 1917 EVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY 1976

Query: 4002 --DEEIENLKQILNNYSAQFSLEHMSPDQADKLPQ-LQGEIERMEKQILSLN---QRKED 4055
               EE E L++ +      +       ++  KL   LQ E+E+ +          Q+ E 
Sbjct: 1977 LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 2036

Query: 4056 LLVDLKA---TVLNLHQHLKQEQEGVE-----RDRLPAVTSEEGGVAERDASERKLNRRG 4107
             L +L+A    +  L   LK+++   E     +  L  +T     V E   S  K  R G
Sbjct: 2037 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSK--RDG 2094

Query: 4108 SMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEE--DRASSSSGTIVQE 4165
                 +A   EV+    K D+  ++        + L  + KD+ +       +S  ++  
Sbjct: 2095 GKVDTSATHREVQR---KLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAG 2151

Query: 4166 AYGKISTSDNSMAQILTPDSLNTE---------QGPECSLRP-----NQTEE------GT 4205
                 +T+   +++ +  D  N +         QG   S +       +T E      G+
Sbjct: 2152 LQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS 2211

Query: 4206 TPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQ-------VAELELWLQQANVA 4258
              P + D   + D   G    + K+  E  E L    T+       + E+  W+     +
Sbjct: 2212 LLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESS 2271

Query: 4259 VEPE---TLNADMQQ-------VLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGAT 4308
            ++ +    LN+   Q       +LEQ + G Q+ +  +  KV   +ET            
Sbjct: 2272 LKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS-------- 2323

Query: 4309 QHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSE-LE 4367
               A +L  K+K +     +       KH E    T+ K        E  +  NLSE L+
Sbjct: 2324 --TASSLQAKMKDLSARFSEAS----HKHKE----TLAKMEELKTKVELFE--NLSEKLQ 2371

Query: 4368 SIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAK-----KMWPQYCQHD--NDT 4420
            + +  + Q   + D   + V EL    Q+   +F+E          +  +   H   +D 
Sbjct: 2372 TFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2431

Query: 4421 TQESSASNQASSPENDVPDSILSPQG------QNGDKWQYLHHELSSKIKLPLPQLVEPQ 4474
                  +N  S    ++ D+I   +       +  D +Q L   L S IK    ++  P 
Sbjct: 2432 ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PI 2489

Query: 4475 VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNL-QTQENMTEEAYINLDKKL 4533
            V  + G               E+    T +++ +     +L      +T  A      K 
Sbjct: 2490 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2549

Query: 4534 FELFLTLSQCLSSVEEMLEMPRL--YREDGSGQQVHYETLALELKKLYLALSDKKGDLLK 4591
                L      ++ EE      L   ++D +     YE L L LK     L+ K   L K
Sbjct: 2550 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK 2609

Query: 4592 AMTWPGENTNLLLECFDNL-QVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
            A     E ++ +++    + +   +  Q  A   ++++K  ++ N+S++ E+K+  +++ 
Sbjct: 2610 AQ----EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2665

Query: 4651 KSKTSLQQSLNEISGQSVA----EQLQKADAYTVELENAE-SRVAKLRDEGERL---HLP 4702
            + K  L + L E      A    + L + D+   EL      R  KL +    L      
Sbjct: 2666 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2725

Query: 4703 YALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA--- 4759
             A L++    ++++ S+ G L      L+    T+ QQ  +L       K   E+L    
Sbjct: 2726 EAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKPQYEQLTAAG 2781

Query: 4760 HGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
             G L +     +L+            +V + L         L   L +R   W +Q    
Sbjct: 2782 QGILSRPGEDPSLRG-----------IVKEQLAAVTQKWDSLTGQLSDR-CDWIDQAIV- 2828

Query: 4820 KILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVE-ETEERLVERI 4878
                 KS Q    L+SL  K  + D   +S      + +ST P     + ET +++ + I
Sbjct: 2829 -----KSTQYQSLLRSLSDKLSDLDNKLSS-----SLAVSTHPDAMNQQLETAQKMKQEI 2878

Query: 4879 SFYQQIKRNIGGKHARLYQTLNEGKQLVASVSC--PELEGQIAKLEEQWLSLNKKIDHEL 4936
               QQ K+ I     ++ Q L E    +        EL  Q+  + + +  + +K ++ +
Sbjct: 2879 ---QQEKKQI-----KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHV 2930

Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
              LQ+       + + S     WL++ +   N    +S  +S  LD + S I +  +FSK
Sbjct: 2931 QHLQSACASSHQFQQMSRDFQAWLDTKKEEQN----KSHPISAKLDVLESLIKDHKDFSK 2986

Query: 4997 EVDEKSSLKTAVISIG-NQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
             +  +S +    I+ G N LL  + ++ A L+  L   +  W     Q+ + + KL +  
Sbjct: 2987 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 3046

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
             + L  ++ +  +  W++  ++   +      P+     ++ + K K  + EMD    +V
Sbjct: 3047 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG---ENSIAKLKSLQKEMDQHFGMV 3103

Query: 5116 DFVNQ---SLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESI 5172
            + +N    SLL +   D E    E     + +  +  Q H     L    Q  ++  E  
Sbjct: 3104 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 3163

Query: 5173 TESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQS 5232
             ES+ ++Q     L+  +         + +  +Q      Q +++Q+ +  +   +L   
Sbjct: 3164 KESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL--- 3220

Query: 5233 YLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMM 5292
               +E+       D   +++ + Q+ S++  QV++  + +++ LQ    +     E+   
Sbjct: 3221 --VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3278

Query: 5293 TIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---SEGSWEKLQEVIGKLKGLCP 5349
               F   ++   PV    ETL+ Q E +++   + E+   S  +  K  +++   +   P
Sbjct: 3279 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3338

Query: 5350 SVA------EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQ 5403
             +       E + ++C     R     + +   +++ +      K +S    +A    + 
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3398

Query: 5404 QEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESS 5463
            Q     +   I+   N         ++ ++  Q DV    +  +Q++         A+S+
Sbjct: 3399 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA---------AKST 3449

Query: 5464 THMLLPGPLHSLQ-RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDR 5522
            +   L   L  +  R   L K +  +A + +  L     F   LESL   ++  EE +  
Sbjct: 3450 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3509

Query: 5523 LHQQEKE--------NPDSFLNHVLALTAQSPDIEHLNEVSLKL-----PLSDVAV-KTL 5568
                  E             L  +L    +   +E +     K+     P   V + K L
Sbjct: 3510 QKPPSAEFKVVKAQIQEQKLLQRLL--DDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3567

Query: 5569 QNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEALK--VDVANSLP 5625
              ++ +W      A  R  +L+GI +  ++F    E   + L  IE+ L     +     
Sbjct: 3568 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3627

Query: 5626 ELLEQQKTYKMLEAEV-----SINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
            +L EQ   +K LE ++      ++Q ++   + QSL++L + E ++  +   +FS++   
Sbjct: 3628 KLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDFSQV--- 3681

Query: 5681 WQNAVQGVRQRKGDV-DGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFS--LYQT 5737
            W   +Q     + ++    +   + F      L  +L +    LS +  Q+  +  L++ 
Sbjct: 3682 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3741

Query: 5738 RSLIHELKNKEIHFQRRRTTCALT--LE-----AGEKLLLTTD-LKTKESVGRRISQLQD 5789
            +S +  L+ ++I  +++    AL   LE      G+++L+  D L+  ++  + I++L  
Sbjct: 3742 QSELRVLQ-EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3800

Query: 5790 SWKDMEPQLAEMIKQFQSTVE---TW-DQCEKKIKELKSRLQVLK----AQSEDPLPELH 5841
                   Q  ++ ++  ST E   TW D+ E ++  L    QVLK    +Q++    EL 
Sbjct: 3801 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL--LSYETQVLKGEEASQAQMRPKELK 3858

Query: 5842 EDLHNEKELIKELEQ------SLASWTQNLKELQTMKADLTRHVLVEDVMVLK-EQIEHL 5894
            ++  N K L+  L +       L  W       + +  D  R+ LV D +  K E+I+  
Sbjct: 3859 KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-- 3916

Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEK 5954
                        +R Q+          F++      +W+ + E K++   DI +E+    
Sbjct: 3917 ---------AAILRSQQ----------FDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3957

Query: 5955 LQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-------EIDDKLNKINDRWQHLF 6007
             Q   ++    F+   L+ K + D L+K+ +K   A        +  KL+K+   +  + 
Sbjct: 3958 AQ---LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTIC 4014

Query: 6008 DVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ 6067
             +   R  +L+   + + Q  +    L  WL   +S +S+ +     + + ++++  E +
Sbjct: 4015 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPALEYETLRQQQEEHR 4073

Query: 6068 DLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMER 6127
             L+  I +H   ++ +      LL  S       E  SIQ+   + D  +  I     +R
Sbjct: 4074 QLRELIAEHKPHIDKMNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKEDVKKR 4128

Query: 6128 RMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIH 6187
             + ++E      +F D   +  + L+        P S        KE++   +     + 
Sbjct: 4129 AVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME 4188

Query: 6188 ERLTQLELINKQYRRL-ARENRTDTASRLKQMVHEGNQR---WDNLQRRVTAVLRRLRHF 6243
            +     E + ++   + AR   TD     K +  + +Q    W+N+   V     +L   
Sbjct: 4189 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4248

Query: 6244 TNQREEFEGTRESILVWLTEMDLQLTNVEH--------FSESDADDKMRQ-LNGFQQEIT 6294
                E+F     S++V + +    + ++E           + +A + +R+ ++G Q+E+ 
Sbjct: 4249 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4308

Query: 6295 LNTNKIDQLIVF----GEQLIQKS--------EPLDAVLIE--DELEELHRYC------- 6333
            +  N   +LI       + +++KS        + L+    +  D+LEE  +         
Sbjct: 4309 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4368

Query: 6334 QEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPS-SPQS 6392
            Q VF  V     +L S +P   D +   +    +E+ ++ ++++++++ E E  +   + 
Sbjct: 4369 QAVFDWVDIAGGKLASMSPIGTDLETVKQQ---IEELKQFKSEAYQQQIEMERLNHQAEL 4425

Query: 6393 LCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGH 6452
            L   V    ++   + P+    + L WD   +   +  H+          L G  ++ G 
Sbjct: 4426 LLKKVTEESDKHTVQDPLM--ELKLIWDSLEERIINRQHK----------LEGALLALGQ 4473

Query: 6453 SWHVPDSPSCPEHHYKQMEGDRNV----PPVPPASSTPYKPPYGKLLLPPGTDGG--KEG 6506
              H  D       H + +  ++      P         +      +L    T     K G
Sbjct: 4474 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4533

Query: 6507 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQ---LNSDISAI 6563
              ++  +  +E   L    E  +    RW+ +  +    K ++   L+Q    + +I  +
Sbjct: 4534 NDLIESSAGEEASNLQNKLEVLN---QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDL 4590

Query: 6564 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 6623
              WL  TE  L   K      +  + +L V    E+  AF+  +    S+    ++ L  
Sbjct: 4591 QQWLTDTERHLLASKPLGGLPETAKEQLNVH--MEVCAAFEAKEETYKSLMQKGQQML-A 4647

Query: 6624 ESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6681
              P+S E  +   +  L   WE+ +  ++  +  L ++L    +FH   Q+ + WL  A+
Sbjct: 4648 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4707



 Score =  181 bits (458), Expect = 3e-44
 Identities = 668/3660 (18%), Positives = 1377/3660 (37%), Gaps = 503/3660 (13%)

Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
            E +LEN+K   +  E+  ++L + +    Q  + L L+Y E L RLE   A    L++T 
Sbjct: 813  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 869

Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
                +    L     R T             +W       E A +W      + ++ K  
Sbjct: 870  RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 918

Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
              E+ RE   LD  +E +  + +  E    E     L  +  Y   ++ Q   +  L Q 
Sbjct: 919  HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 974

Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
            +   Q++ E++   E     +E T         +Q+         + K ++LVQ  ++E+
Sbjct: 975  VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 1032

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
                +    + N   +  T  Q       P  S+          K  +  + I +  +I+
Sbjct: 1033 EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 1080

Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
                 TI   +         +A   +     NE +  S  +     +   N    ++   
Sbjct: 1081 I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 1132

Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
            ++Q+ +N+             +  WH  +NE+D    S V  I    PG+ Q+ + NL  
Sbjct: 1133 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1192

Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
             F+ + + SQ ++  +    +QL K   V  + Y +LLKS E   +  S      ++  +
Sbjct: 1193 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1252

Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
            +R  L +    +   +    ++ +L  S+F   E   +  E + L   +  ++N+     
Sbjct: 1253 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1312

Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
             Q     S+P ++   + V+   ++V SM    + K+KT+ L      + E      E  
Sbjct: 1313 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1372

Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
            L   E ++ +   ++  I+ +  ++ E+       +   VF      LQ  K + +    
Sbjct: 1373 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1422

Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
              E+ K   ++  ++D   E   Q++  +       H+  D  ++L  L+G I +  K  
Sbjct: 1423 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1473

Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
                   +D +  ++ T     + +++ Q    +     +  ++  V+E +  + K++  
Sbjct: 1474 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1529

Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
            ++ +  Y A V++ E++  + ++    ++  P              ++  R  SS+  I+
Sbjct: 1530 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1575

Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
            QE +  + T   ++  ++T       DSL   +  E SL   +                 
Sbjct: 1576 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1634

Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
                   E+   PP     + S +     E   E                T  E  E+  
Sbjct: 1635 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1694

Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
              KT      L   ++           +V VE E + A+ QQ  +++L G   +LT+ E 
Sbjct: 1695 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1753

Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
                H+ AF++     E  K Q   +    Q + +  +  L  V  N E       EK S
Sbjct: 1754 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1811

Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
            ++    I +K +E + +   + +NL       EL+ +VT   +   +K    +Q+ E K 
Sbjct: 1812 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1869

Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
              +   D++  ++ ++++   ++ Q    N T  +      A   E++V          N
Sbjct: 1870 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1919

Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
            G+                   L+E  V   +G                     TTQ E+L
Sbjct: 1920 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1938

Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
             Q+   ++ Q    +++   + +  +  ++ L       S EE  ++ +  +E     +V
Sbjct: 1939 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1994

Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
            HYET         LA S+KK  L  ++          LE FD      EH    +    +
Sbjct: 1995 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 2039

Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
            +L+AG D       ++KR       +I  K  L+     ISG  V   A+   K D   V
Sbjct: 2040 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 2097

Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
            +       V +  D   +R    Y+    +   L+D++D         Y + S   +   
Sbjct: 2098 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 2152

Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
            Q  +    + + E + +  + L    L++TK   ALQ QI + +V  +KL     ++   
Sbjct: 2153 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2208

Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
               +LP+    ++T   + V   + L +   +   KLQ  L +     +    +   +  
Sbjct: 2209 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2267

Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
            + S+L     V      L + IS    ++++I G+ + +     + K+ + +    +   
Sbjct: 2268 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2327

Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
            L+ ++  L  ++   + K    L +++ L   +  +   S++L  +LE+    L      
Sbjct: 2328 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2387

Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
              +V++    ++ + + F E  K ++   SL   + S      H   +D A +       
Sbjct: 2388 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2441

Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
             +K+  +   + + +E +   Q +    +  +  + SW+     +T+ +  +  PS  A 
Sbjct: 2442 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2497

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
             +   L+  K+ + +   K   +  VN S + L                     +  + E
Sbjct: 2498 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2557

Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
                   EF  + G         +++  +  +  +L  KI  L   L  + +++ +   +
Sbjct: 2558 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2617

Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
              WL+   +     Q+   P    +V+  +   +  E +L      + ELK     L   
Sbjct: 2618 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2677

Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
              ++   P  +   + ID  +Q+       R   L + +   T  Q+V   L++W +  +
Sbjct: 2678 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2737

Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
            L   V               P+ +    L  Q + +Q L  E  + +  +E+L    Q +
Sbjct: 2738 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2784

Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
            + +  G  PS+  I++E+     ++W  +   ++D+       +     Y +     + +
Sbjct: 2785 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2843

Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
            L   + K      +S   + + + L  A +  +E+Q + ++ K  +A  ++ S L +  +
Sbjct: 2844 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2902

Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
              ++     L G L S     Q+A  +++ +    A+  +F     +DF   L++ K   
Sbjct: 2903 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2958

Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
              EE+N        LD L    K++ D        LTAQS   E        + LK   S
Sbjct: 2959 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 3012

Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
            + A   LQ   +   W        ER ++L+     EK L   E+      WI   +   
Sbjct: 3013 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 3070

Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
            E +K      +  NS+ +L   QK        V +    A+S       LL   EI+   
Sbjct: 3071 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 3121

Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
            E +T+ +K L  +     + +  +K  ++ + +++++F    +   R L      L    
Sbjct: 3122 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3181

Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
            ++  Q   + Y T   + + + K +   + +   A  L A + ++  +D K    V  ++
Sbjct: 3182 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3237

Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
              +      +  Q+ E     ++ ++     +  I+E+ S+      +  S  P+    E
Sbjct: 3238 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3297

Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
             L  +KE IK   + L A    N    +T K  L       D++ +K  +E L +Q   L
Sbjct: 3298 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3357

Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
              R   R++++E  +     F  K KE    L + E        + +E         M +
Sbjct: 3358 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3417

Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
              QK   EEI      +  +  +G  LI+++ KS + + ++  L+ +N RW+ L   +  
Sbjct: 3418 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3474

Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
            R  +L+E      +    + +L +W+   E EL         + + ++ ++ EQ+ LQR 
Sbjct: 3475 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3533

Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
            ++   + VE       V+  + +  A   E  D ++  +    LD RW  +   +  R  
Sbjct: 3534 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3586

Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
            ++E    + Q+F +      +WL + E+            +  +E++ + +A +  I   
Sbjct: 3587 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3646

Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
            ++ L Q   I +  + L+ RE++    S+L     + +Q W   +Q +  +    L+   
Sbjct: 3647 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3701

Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
               + F      ++ WL E+  +L+  +V+ +S      +  +L   Q++I L    +DQ
Sbjct: 3702 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3761

Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
             ++ G +L++++   + ++I+D+LE +    +++            +  +  RRL S   
Sbjct: 3762 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3821

Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
              CT   + E E    ET +            P+E++ ++   +   +  +   S    +
Sbjct: 3822 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3881

Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVP 6457
             P   R G E  V+ D+   E         +   EE +     S    ++     SW   
Sbjct: 3882 VPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3938

Query: 6458 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6517
                       ++E D+    +    +   +    K ++    D  K G +++    ++E
Sbjct: 3939 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII---DDLVKSGHKIMTACSEEE 3995

Query: 6518 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6577
               +    ++    +D    I ++      + +  + Q       +  WL +T++ +  L
Sbjct: 3996 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 4055

Query: 6578 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
                P  + + +  + +  +++ +    +K  +  +N +  + L+    E   +Q +   
Sbjct: 4056 --PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 4113

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADP 6696
               L+   +  V      L +++ Q   FH     +L  L     R RQ   ++   A+ 
Sbjct: 4114 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS---AEV 4170

Query: 6697 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              + E   E   +  ++ + QP  + L++    ++ +  G D    +     ++ KL Q+
Sbjct: 4171 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD---KDISAKAVQDKLDQM 4227



 Score =  174 bits (440), Expect = 4e-42
 Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)

Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
            LQ Q E  K F +KL A ++     + K    +L   ET   + V   + LE  S+QC  
Sbjct: 3299 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3355

Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
                LL + +  +E      K LE   S L   S+       L+++   +++ +  +G +
Sbjct: 3356 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3405

Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
               + Q LN             +GKQ                S S   LE  +  +  +W
Sbjct: 3406 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3465

Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
             +LNKK+     +LQ  L H   +    + L  W+  ++  +   K  S     +   ++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3521

Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
            + I       + +D++ S    +   G ++    E  D   +   L+  + +W  L+ + 
Sbjct: 3522 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3581

Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
                 +L  + +      + +  +  W+  +E +  + + + +   AS+++  + +HK  
Sbjct: 3582 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3639

Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
              ++ ++ + +   V+  QSL  LS+ + +     + +F++        W+  +    + 
Sbjct: 3640 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3692

Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
            + + L+Q L  +    E++++++N WL    ++L  L            Q+ E  +  + 
Sbjct: 3693 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3751

Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
            +LL  Q+++  L      L+ LKQ+        V +++D    I   ++  + + T V +
Sbjct: 3752 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804

Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
             L+ ++Q   +    +++L   ++ + +     + +   V+   E  + Q+   + L+ E
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3860

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
            A++++   + L EV   L  L P  A E +E+     ++R+  V+  I  ++++  + + 
Sbjct: 3861 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3920

Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
              + +  A     + + + E K   L +I +             QD    Q  VQKT   
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3968

Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
              L++  ++D L +    S H ++     S +    ++K L      ++ +     +  +
Sbjct: 3969 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 4022

Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
            +LE  + L+    E  + L     E   S ++ + A   +   +    E   +L      
Sbjct: 4023 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 4081

Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
             K  +  MN+     T   L   S  +G  + EK++     + Q+ E +       +EA+
Sbjct: 4082 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 4136

Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
                    K+D +  SL  ++E+ +    + AEV  I + I++    S   + LQ L  T
Sbjct: 4137 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4196

Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
             ++ R E +   S  TD+  +A    +  +  +D +V  W++  T VE            
Sbjct: 4197 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4251

Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
              +F  D   L+  +K  + F           S+ + +    E   +EI   +      +
Sbjct: 4252 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4311

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
             L  G +L+       K  V + I +L  +W  +     + I + +  ++   Q +  ++
Sbjct: 4312 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4369

Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
             +   + +   +     P +  DL   K+ I+EL+Q  +   Q   E++ +  +A+L   
Sbjct: 4370 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4428

Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
             + E  D   +++ +  L   W+ L  R+  R+ ++E  L     F     EL AWL   
Sbjct: 4429 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4488

Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
            E  + +   +  +     IE  +   ++   L  ++ ++ + + G+ LI++S    A+ +
Sbjct: 4489 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4548

Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
             +KL  +N RWQ++ +    R ++L       +     + +L+ WL   E  L  SKP+ 
Sbjct: 4549 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4607

Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
                    + +   EQ ++  ++     A  E+  ++          C    E + I Q 
Sbjct: 4608 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4660

Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
              +L  +W ++     ER+ K+EE   L  +F +    F +WL  AE+T    +   ++ 
Sbjct: 4661 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4720

Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
             +   ++   + F  +++    Q+  ++K    L   ++      +K ++     RW+ +
Sbjct: 4721 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4780

Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
             +R+    R L     + ++F      ++ WL E +  L + +E  ++ D    ++ Q  
Sbjct: 4781 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4840

Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
             FQ+ +    +  D     G  L +K+   D  L ++D L EL      + G+
Sbjct: 4841 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4893



 Score =  160 bits (404), Expect = 5e-38
 Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)

Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
            LT  S    LS G T+ L   +  A T     G+  +    + P+ SL+   KL +I++ 
Sbjct: 708  LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 765

Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
            +L  K S++   L E +I       L   + E++ Q +     SDL + + S L++H   
Sbjct: 766  LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 819

Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
                  KN +      + +LKE  + SE + +   KL        LE + +K+       
Sbjct: 820  ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 869

Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
            ++ ++HL   H    +S    +   L + E   +  A +  +    + R +D H  L + 
Sbjct: 870  RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 925

Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
            L  +EE  K ++E  E+         L  +A  A  + Q+  + QL   ++++      +
Sbjct: 926  LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 985

Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
             E      EAT  +   +  +++    +    +   ED  Q   +   +++ +   I   
Sbjct: 986  FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 1045

Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
                ++++ L       PL               E  I K  E +L      A+ + I  
Sbjct: 1046 MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 1105

Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
                +  P V        K   D++N    Q+ N L L   + SH     +    YL ++
Sbjct: 1106 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 1163

Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
             D +R   +   K    G   +H       Q + ++ FL+ +Q        D+T L KE+
Sbjct: 1164 IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1219

Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
                 Y  E  K+    E+                L +++  + L++Q++  ++  D H 
Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1279

Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
                + E +  +  +  L     T+ N  +EF S +        +  +L  + +  N++ 
Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339

Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
                T    L     V +NT +    +   + K  +      E  + + K  +E  + S 
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1392

Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
            LK  RS   EK+  F     E Q    + +   ++     L+ DW   K D  VE   + 
Sbjct: 1393 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1452

Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
             + ++ +        +S+K   D    +++   Q       ++  Q E  + L TQL  +
Sbjct: 1453 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1512

Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
            K  +  +E       EC    E  +       L  + Y A  +D+  ++ +  ++ + S 
Sbjct: 1513 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1571

Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
              ++++F +              Y+     S+K L  +++SL+    + V    +++K++
Sbjct: 1572 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1631

Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
            ++I K         K      KI  E +S     + + L   Q+   +HG +  +++ + 
Sbjct: 1632 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1690

Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
            +  +QV    E     F+  + ++Q+++ S  ++ +++ +  R +  +E+      +   
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750

Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
            T+ +   H  + + G   +++K+   ++E+                KN E   N LK+  
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1807

Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
            E L                   E L+L+AE   K+ D  +   +KE    + A   L E 
Sbjct: 1808 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1867

Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
               I  L D   ++     +    H  ++ +            ++ EE +     L T  
Sbjct: 1868 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1927

Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
               +  T E+L  QYQ +             V+ +TQ +Q L   LE++  + +   K +
Sbjct: 1928 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1984

Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
            L     E  +      A +E ++K  H    + Q+EL++ D+  +     L    +EL  
Sbjct: 1985 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 2040

Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
             E     D +  L  +  R + F ++    + HK    R      + + E A S  + + 
Sbjct: 2041 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 2094

Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
              +     ++ V+ ++ +  DR  ++  KC +L    LK + D      D S   L  LQ
Sbjct: 2095 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 2153

Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
                   K L E I    K L    EE    Q  +S  +    ++KK  EV+L A  S  
Sbjct: 2154 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2211

Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
                    +L  + +  K L D+I+ +  +     +   EK  + +  +    D L ++L
Sbjct: 2212 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2262

Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
              M  +E S KE     L+    QD +  ++ +   I  +      +N ++K      D 
Sbjct: 2263 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2322

Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
              A   Q   +  S +   A  K +E   ++  +++TK+  FE+L  +L T ++ +T  L
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2381

Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
             +          L++Y +E+ +  +E    LE +  ++      G P +   + L K   
Sbjct: 2382 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2440

Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
            L      ++D + EK   ++S + +L         L+  ++E   K   ++ +F A++  
Sbjct: 2441 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2500

Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
              + LE+ K   K++E       +++ V    +S     S   +  +A+  ++   A+++
Sbjct: 2501 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2555

Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
                +T  E     + L  ++   T      E+ G+ L   ++ L  K   L +A +E  
Sbjct: 2556 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2615

Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
                W +++ +   +W+      + EA+     Q +  E    +     +EL + L  L 
Sbjct: 2616 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2675

Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
            +   +                K Q L  L + R + ++    +    +TV A  ++    
Sbjct: 2676 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2735

Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
            KE    +L  +  +  ++ T+ Q+     +E    K  ++Q T + Q +  +   + S +
Sbjct: 2736 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2795

Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
                E+L ++ +K       + +  R  + +   +   + +S +      L D+D K+S+
Sbjct: 2796 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2853

Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
             +  S+   AM +++E        +++ +QQ+ K I+ AQ + + +   +   + K  EL
Sbjct: 2854 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2908

Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
              +++ I      VEQ      + + +      Q+QQ+S+  +     +  + NK+   +
Sbjct: 2909 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2968

Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
             K++    L+K                E  I    +LL      +       L T+  + 
Sbjct: 2969 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 3028

Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
             T               ++ AL+  EQ   L   +     +LE++    +  E   SI +
Sbjct: 3029 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 3088

Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
            L +    + Q   ++E L         V  I+ EV     KS+ ++V  +   L SK+  
Sbjct: 3089 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 3148

Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
             +   ++  +  EV  E+ R ++          ++         L + QT  K L   + 
Sbjct: 3149 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3208

Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  +L QD+ +              +E + QE + L + V ++ +  + +++ +   
Sbjct: 3209 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3268

Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
             N     FS      D+ D +  +  + E ++KQ   I +  ++ E L+           
Sbjct: 3269 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3328

Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
              L  E+      G++RD L A++ +   + +R A  R+    G++  L     +++E S
Sbjct: 3329 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3386

Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
            +      +KAE   +S   +      ME +       TI Q+          +M ++   
Sbjct: 3387 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3421

Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
            + +   QG +  +         +  +  +T  +E D  D +     L  +V +   +  E
Sbjct: 3422 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3481

Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
             L  C              V   EL   Q   + E + + A +Q Q L Q+L+  +    
Sbjct: 3482 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3541

Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
            E+      K+A   E   K + L          EAL  K +T    LE + ++ Q+ H  
Sbjct: 3542 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3599

Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
                            E L+P+N  L+ +E  +        Q    ++Q+ + K +E  D
Sbjct: 3600 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3642

Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
             I             + +H +       +    SS E+ D+  S L       D  Q  +
Sbjct: 3643 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3683

Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
             E+  K       L +   +  +     V + N+              L ++  + S L 
Sbjct: 3684 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3729

Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
             Q+  TE     L K+  EL +     L    +V++ L       +  +G +V      L
Sbjct: 3730 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3785

Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
            E +K  Y  ++    D+ K +    +    L    + L   L+  +   +     +  G 
Sbjct: 3786 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3845

Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
            + +++ Q   K L  +  K+  +L  SLNE+S   +     +A       E  E  VA  
Sbjct: 3846 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3895

Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
             ++ ER  L    + Q+V +++  +       +A   ELS  ++TE+++  +  G + L 
Sbjct: 3896 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3952

Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
            +            QT +++ +Q     +I  HK     LV +   ++ A S +   S+ +
Sbjct: 3953 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 4001

Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
              +       T  +I  E+  Q       + Q WE ++E +  L  + + +IS LP+ +L
Sbjct: 4002 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 4060

Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
              ET  +  E    ++Q++  I      + +    G QL+      EL  G+   ++E++
Sbjct: 4061 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 4111

Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
            ++   L  +I  ++ +    L   +S +    D++ + LES +  +   + Q  ++S ++
Sbjct: 4112 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 4170

Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
            + I+  I+     S ++++   L   +   G +++         + A   Q +      +
Sbjct: 4171 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4224

Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
             Q+  I E +H L  E+      + E+    W +++    + +D+      +  P    S
Sbjct: 4225 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4284

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
             VK   +  +  R E+D  Q  +D V N     ++ C    K   +    + + E+N  W
Sbjct: 4285 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4340

Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              ++     +I  LE+ +++  + ++ +Q + +W++    +L ++    + +   K    
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4396

Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
             Q IE     KS+A  + +     L   A  LL+      D         EL     S+ 
Sbjct: 4397 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4454

Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
             ++   +  ++  L     +    DE+          +   KPV    + +  ++     
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4514

Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
            LQ++  + + + E + +    L +      A  ++ K +  ++RW  V +    + Q+  
Sbjct: 4515 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4574

Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
              L+  K +   HGE    L+Q   + +   LA+  + G      E L   ++     + 
Sbjct: 4575 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4630

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
              +  K    +   +L R P+ AE++    +   +++L            +R   LE+ L
Sbjct: 4631 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4686

Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
             + A EF   L  F ++  + E    +       LD +  Q  E+   F N V +   Q 
Sbjct: 4687 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4744

Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
             +++    HL   S K  +  V +K L  ++  +W +     +ER   L       K  +
Sbjct: 4745 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4802

Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
              E W +L+E +EE+ K     +++AN   ++  Q   +K  +  +    ++ D+     
Sbjct: 4803 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860

Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
              L + T + ++  +     S+L D+W        +R+  ++  +     FT +++ L  
Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4920

Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
            +L      L+     E   ++    L+  L +    FQ+   +RT+    L+   + L+ 
Sbjct: 4921 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4975

Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
                    V  ++ +L   W+ +       + +L   ++Q   F S V    +   +  E
Sbjct: 4976 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 5034

Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
               R   +    ED L  L   +   KE +K+LE+  A     L +  TM   +      
Sbjct: 5035 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 5087

Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
            + +  +K  I  +  ++E++       +Q +   L   +   E  + L AWL   E  + 
Sbjct: 5088 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 5147

Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
                  I + IE++ K  + E   F E ++  KQ     +  + K RAA+
Sbjct: 5148 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5195



 Score =  155 bits (393), Expect = 1e-36
 Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)

Query: 616  ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
            ++L +   E  +L E     VE + ++    S+ISK L+   K  +   SK ++      
Sbjct: 1601 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1660

Query: 669  ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
                        + L + K      D   N L K+ K   E     FS  +        +
Sbjct: 1661 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1720

Query: 714  QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
             ++K  EK   E + E+  +L+   D+      +LIG  E +       ++     +  E
Sbjct: 1721 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1779

Query: 768  ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
            E  K +        E++  +E+ L+ + + +S ++         ++ K+ EAK K +   
Sbjct: 1780 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1833

Query: 828  VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
            +K   + K L  V        +  +    ++EES+ ++E+ +     +    E  G   +
Sbjct: 1834 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1890

Query: 880  KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
            KHK+ +  + T       K+     +E+  N+ E D+   +     ++  +++ +  +  
Sbjct: 1891 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1950

Query: 935  LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
              + Q +  I   + +  +L+ + Q ++ E+K   +   K L   +E   +E     +L 
Sbjct: 1951 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 2010

Query: 994  HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
            H ++      EEL        E +  L+  EQ++E L   A +I+  +       S +E 
Sbjct: 2011 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 2064

Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
             I         T S NR  +       +K D       A    ++  L       +    
Sbjct: 2065 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 2122

Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
                   ++  L+++Y  Y D    L   LQ  +   +   S         LQ +L + +
Sbjct: 2123 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2182

Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
             ++ +  ++    E +    E  +          NDI+K       D +  R  +L  ++
Sbjct: 2183 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2237

Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
            N R E L+  L   L V+              S L     +PL+  A+Q       D I 
Sbjct: 2238 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2290

Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
            +++   QD   +Q  I N + E     ++   P    ++Q  +     +F   +H+    
Sbjct: 2291 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2349

Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
                      V+  E+  + L+ FL +    L    +  + VT+LS    +   E     
Sbjct: 2350 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2409

Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
            K+ E    L+K+ + H    DK L +     L   FK+ E      +   TSC+  LDAF
Sbjct: 2410 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2469

Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
             + +     +   +E T++  +++   F   +L K+++D +    K  LK P +  V + 
Sbjct: 2470 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2526

Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
              SL  L   +    +    ++             N+   + +    ++ +   +    +
Sbjct: 2527 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2586

Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
            E+   L+ + + +    L  L++ Q   S +   +QK     +         + +    +
Sbjct: 2587 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2646

Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
            +E  K    E  + V+K+ ++   L   L +     E P  K+    +D +W ++N+ T 
Sbjct: 2647 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2706

Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
            D  + L  +     +   ++  + +W  EK L    L  L+  D   L  + Q  +    
Sbjct: 2707 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2765

Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
            EF+ R  + + L  + +  L     + S+   ++     +T + +  +L+G  ++  + +
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2823

Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
            DQA  +    +SLL++LS          S SL + T                +EIQQ+  
Sbjct: 2824 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2883

Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
            Q K +  L E+    +  E   +EL +Q E +   F   +   ++H   L          
Sbjct: 2884 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2943

Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
                ++F  W    K    +    S     +E  ++   DF  TL  ++   ++  +  +
Sbjct: 2944 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 3003

Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
            ++      +    L   L   +   +      + R  +L++SL++ L+ ++    L  W+
Sbjct: 3004 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 3063

Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
                N  E+ K   +P  GE +    ++L ++ +Q F  V  LNN+           KE 
Sbjct: 3064 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 3123

Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
               E + +I +   + ++  +            ++  E+ +E K                
Sbjct: 3124 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3183

Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
                       +L T+ +S   L H V    K + + L+V          E    K    
Sbjct: 3184 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3232

Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
            +LL+ E  A+  + + Q    +   ++  L  I +  +    + S +    ++L      
Sbjct: 3233 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3292

Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
              + E   + KE ++  L +L+       AL           K+     + + DL  + +
Sbjct: 3293 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3345

Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
            +L++   Q N LL+  +  +  E+    IK L E  S L++    +Q  +    EH+  Q
Sbjct: 3346 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3399

Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
              V     T++     F  F  + +      E LQ  Q+  N L            L +S
Sbjct: 3400 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3444

Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
              ++TS+ G +   DD+ +  +   K +  R A  ++ +  C      L S+L     TE
Sbjct: 3445 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3504

Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
            +     L   +K  +++   V+   QE   +++L +D     E+ K    ++A + +   
Sbjct: 3505 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559

Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
             + +  Q S+ ++  E  +N  E +N+ LE  +++           NE L  IEK     
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3619

Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
            E        LE+    +K     ++ HN        IG S + L +     +   K   S
Sbjct: 3620 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3679

Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
            Q   + + QE   +    ++  L + +      ++ + +L+++   ++ +  +  S   L
Sbjct: 3680 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3738

Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
               W+  S   V   D  L +  + Q L +G E ++Q        IQ K       Y + 
Sbjct: 3739 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3795

Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
            T L   V  T     +Q   L  RL S  E            +++   +   VLKG    
Sbjct: 3796 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3848

Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
            QA+++ K +  E K  K L D +N +         W   E L  + AE+    ++    I
Sbjct: 3849 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3908

Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
              K++E                  + W      +L     I L  D   +Q++  K    
Sbjct: 3909 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3968

Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
             IL  +  ++ L +     + + +  E   +   L+ +   Y  +   +++R  QLE   
Sbjct: 3969 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 4028

Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
               + F+    +    + E+++ II ++   A E E      TL   Q+E +++   I+ 
Sbjct: 4029 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 4081

Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
            H   +  + +      EL+  E   ++++        ++I+  ++     ++  I    Q
Sbjct: 4082 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 4141

Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
            FH+K   + E   S++R    L Q  +  +  E+  +K++++  K   + + KL+ +++ 
Sbjct: 4142 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4196

Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
            +            G + D S      +LDQ+        T V E+E +L + ++  + F 
Sbjct: 4197 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4256

Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
             +H      +   +    DL+   +   V+K    + E+ R     L + ++    L  E
Sbjct: 4257 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4316

Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
            +I    E    D    +K I ++       D L K  ++ + +L          QD L+ 
Sbjct: 4317 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4370

Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
                ++    +L     I  +++ ++ + +       EA+Q+Q+  E  + +A   ++K 
Sbjct: 4371 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4430

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
             EE  S+   V+  L E + +   L   I  R + L  A   L +++ A+   +  +T  
Sbjct: 4431 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4488

Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
            E ++   +  VG   +++E+ L K   L++ V   Q   E +          S+ E    
Sbjct: 4489 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4547

Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
            LQ  L+ L  +   + E  + ++ + +  L   K +    ED+   L+  E  L   + +
Sbjct: 4548 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4607

Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
              LP + +E L   +E   A  +   + K  + K +Q+L     RC ++    + + ++ 
Sbjct: 4608 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4663

Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
            L EKW S+     E +   EE                 W   +E+      R ++ILD +
Sbjct: 4664 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4723

Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
              ++ E  +   +  +  E++ EL      L    Q  + V  + LL+++  +  + +Q 
Sbjct: 4724 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4783

Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
            + E   +++           A+ ++    E   K L    ++  + + ++T++ +   F 
Sbjct: 4784 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4843

Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
            K + A  + +  T  + +++  +     D+ +  +   EL              Q+ L++
Sbjct: 4844 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4903

Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
              L      + L+     +Y + P   E Q      +    L D  +    E+ K + S 
Sbjct: 4904 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4963

Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
             A++R   E+  G  +    V+  +Q+ S   E    +       L+    +  E  S V
Sbjct: 4964 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 5023

Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
              ++E         +  G   +  D L     Q+++  ++ E + ++LNKAT   +    
Sbjct: 5024 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 5083

Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
              + D + + + WI      +      + L     H   +  AL     K  LL ++   
Sbjct: 5084 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 5138

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
            L+       TD+  + I +   +V AL    Q  ME + + Q   D V
Sbjct: 5139 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185



 Score =  155 bits (392), Expect = 1e-36
 Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)

Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
            +L  L+S+  ++L +  ++  FS     +++       Q  Q+ +++ +   +E   Y +
Sbjct: 1186 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1245

Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
             ++++     N      +  D+ + QI    +   L E   R++ Q+   K++  L    
Sbjct: 1246 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1297

Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
                        KDD+ ++  +C++   +   +S+   +   LN +L++           
Sbjct: 1298 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1345

Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
            +   + +  + V ++TQ + A+ KL E     +++ +    + +  ++  +  ++  DE+
Sbjct: 1346 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1403

Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
            +       +ELQ      D M +  +  +++  +     K+ A + +E+ + ++      
Sbjct: 1404 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1454

Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
                        +DN L+ L  + K+ +          +++  VE++ + +   +E+   
Sbjct: 1455 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1500

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
                  T L++ K  ++ IE ++  +   +   E  S  V D +      + +++SQ K 
Sbjct: 1501 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1560

Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
                   +     I +++      Y    TLM +      D+   L+++++ L+   K  
Sbjct: 1561 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1620

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
             E+A          +LQ      S     AE   K  +  K+K + E+     ++  E L
Sbjct: 1621 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1670

Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
            + + L       K   + RN++++ +         L  S  LL  + L Q+++ + + D 
Sbjct: 1671 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1722

Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
            +   ++ V    +E K+K+      LT  E   + +    +     + + K   + ++L+
Sbjct: 1723 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1782

Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
              ++  +   A + K          + + QE + LI    E    EA++K   + L+A Q
Sbjct: 1783 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1838

Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
             + +E+D  ++T ++E T         E++    QL+  K +   +  ++ N   + E  
Sbjct: 1839 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1888

Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
                +Q  E+     +E D           N  LL  +V+  V     NL  +   +K  
Sbjct: 1889 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1948

Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
              +++   +       +       Q Q    E++++L++ +K+L    E      AL   
Sbjct: 1949 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 2003

Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
             + + L      E+     D +     L  Q   Q +E  +   D+I   + KL   K+F
Sbjct: 2004 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 2061

Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
             +           + + + D  Y  +  N VLE +         ++D      +++  L 
Sbjct: 2062 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 2111

Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
            H  ++ +S   +  ++   +K + ++  + E     + A + + +A TA +   E  + +
Sbjct: 2112 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 2170

Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
              +++ +L E + LQ Q+++       +     VL DA  +L   K  + + ++ I    
Sbjct: 2171 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2226

Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
                     VG  E+  +    + E+L+ T+     +QD L E L  + + E+ L+ Q  
Sbjct: 2227 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277

Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
                   LQ+++SKN  +++    +++      E  K + +  +    ++L      L  
Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337

Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
              S     ++E L ++E+ K  V    +  E   KL+  L       TE D  G  + ++
Sbjct: 2338 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2394

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
               + E     LE  K  E+    LK+     S  +  + A++L+   NL ++  E+  T
Sbjct: 2395 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2451

Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
                KEA T+          CQ  E ++  Q+L+  L   I+            + VP  
Sbjct: 2452 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2490

Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
            Q     ++   K L+  +K +E    +  E        I+L N     TT  + +A    
Sbjct: 2491 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2549

Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
                   +     +E+F        KG  + +  M  +   Y ++  ++    AE+ +++
Sbjct: 2550 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2604

Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
             + +KA E+        +K++    K   + A     E +   +   +    +  +N+ K
Sbjct: 2605 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2663

Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
             QE++ K+ + L+          W   L E+DS+ Q++ +   D  Q  E   N +  FQ
Sbjct: 2664 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2723

Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
                Q +Q     E   S              Q  +  + ++E++      E        
Sbjct: 2724 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2783

Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
            +L+ P +  SLR                    LS     +  A+  S Q  +LL S+   
Sbjct: 2784 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2843

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
            L DL     +     +  +  NQ     QK+ + + Q        Q + +D+ A+  E  
Sbjct: 2844 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2903

Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
               +   +++ IL S +  +   E H++H +    +    ++   +  ++    +  Q  
Sbjct: 2904 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2963

Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
              P+            + +LE++ ++  +  K +  Q++ +++ I   + +L        
Sbjct: 2964 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 3006

Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
            L+    ++A    +L  ++   +   KQ+    N+ KE L   +  K  V  L   + + 
Sbjct: 3007 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 3066

Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
            Q  +E  +     +E E  +A+  + ++++           N   S+  +  +++EV   
Sbjct: 3067 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 3126

Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
              KS     D   E+         ++ +  K+ +E   S  S   +Q A  ++   D+  
Sbjct: 3127 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3184

Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
            +Q  +   L   Q  + SL+  + +      +  D  +++SD++G  +   +VE    E 
Sbjct: 3185 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3244

Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
            + +      + + LE  LQ      N   E  +  A+               + L++Q  
Sbjct: 3245 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3304

Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
              +A L ++E  +A      +TCK     ++   D    + + EALS +    L   +  
Sbjct: 3305 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3364

Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
             E+V+     L+E +S+ +  +IL + +E EH+E+  PV + E E+I     Q +  K F
Sbjct: 3365 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3419

Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
            Q++++  L+  +Q  +++    I+  AK    Q  +HD D       T  +  A   A  
Sbjct: 3420 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3479

Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
             E         D  +S+LS        W     EL +  K P                L 
Sbjct: 3480 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3531

Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
            +L++ + ST                    + IL  +++ + R+     + +T   QLE +
Sbjct: 3532 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3591

Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
               A           E    ++K+L       +Q  S +EE +   +   +D      H 
Sbjct: 3592 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3649

Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
                     L+ A+S   G  LK ++   E+ +++    D  QV     Q  +  RS+ L
Sbjct: 3650 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3697

Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
            +  L   + +  +   L + L +    L + S+ + S + + +Q  +      ++   + 
Sbjct: 3698 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3757

Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
             V +    G  L L      EV  ++D L++    ++ARY +++  S  V ++ + AL  
Sbjct: 3758 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3812

Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
               L    E     L K+  E L++   +  K + A QAQ+         +N+K     L
Sbjct: 3813 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3871

Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
              V+  LL      +++P         W  +    K++ E + +  +   ++ QK EE D
Sbjct: 3872 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3916

Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
               A++ +  +   +    +S + ETE++L+         ++ S   Q+++    +  R 
Sbjct: 3917 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3973

Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
               +++    G +++ + S  E +    KL+      +    +N +   +L R Q+L+  
Sbjct: 3974 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 4033

Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
               +    ++L  WL  +Q  ++     +L    + +T+R       +  + + E     
Sbjct: 4034 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 4086

Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
              +   G QLL L   +  +++      +  ++ +   +      L +   +       I
Sbjct: 4087 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 4146

Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
             +++  +  +  +     S+ +     ++K  + ++K   ++M+  Q + + + Q   ++
Sbjct: 4147 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
                  +  D+ +K  +     + L +M   W  +H ++  +   L  ++E   +     
Sbjct: 4205 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4259

Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
              L   ++  ++ ++ L+ P    SV K     Q+    +  +   L E     + L S 
Sbjct: 4260 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4316

Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
             +    +         IDEL     S+      ++++L+ +MQ+ +Q       ++D V+
Sbjct: 4317 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4376

Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
            +   +    +    P+   LET++ Q+E L+  + EA   +   E+L      L  K   
Sbjct: 4377 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4432

Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
             S    +++        W  + + I ++  K +  L     + +A  E  A L   E   
Sbjct: 4433 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4492

Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
             +   +   G+  A  +  A   +  LQ+DV   Q T EA  +  + L       E+S  
Sbjct: 4493 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4547

Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
              L   L  L QR   + +    +  + +  L Q K F   +E L+  +   E +L    
Sbjct: 4548 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4605

Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
                L +  KE  +  +    A  A+    + L     ++  + P S      + + N+ 
Sbjct: 4606 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4665

Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
             +W        ER ++L+  + L  +F    + +I  L + E+ L V    S P L+   
Sbjct: 4666 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4722

Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
              +++ E +V  N+   +S+  Q ++L  T T ++  ++ + +     L      RW+  
Sbjct: 4723 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4780

Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
            VQ + +R   +D   ++ + F  +   L  +L ++   L S ++        +T+   H+
Sbjct: 4781 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4840

Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
               K +    + +    T   G  L   T L      +   +S+L+D W  +  +  E  
Sbjct: 4841 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898

Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
             + +  +    Q    ++ L   L  ++ Q  +  P +H D+     LI   K  ++ L 
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4957

Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
              T +++ L+    +L      +D   +K Q++ L  +WE +C     ++  +E  L   
Sbjct: 4958 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 5016

Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
              F+     L  WL + E       VL   + ++  +I++  K+ M+++        +  
Sbjct: 5017 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 5075

Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
             MGD ++   +      I   +  I  R++ +        ++L    A +    + +  L
Sbjct: 5076 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 5135

Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
              WL   E+ L+   K V+    + +E++  +AE Q    ++ +    V+ V        
Sbjct: 5136 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5193

Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
             D  +                           ++T+ ++       L  +W+ +  +++E
Sbjct: 5194 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5253

Query: 6127 RRMKIEE 6133
            RR K+ +
Sbjct: 5254 RRRKLND 5260



 Score =  146 bits (369), Expect = 6e-34
 Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)

Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
            P+  +AM P++ F++     P  +E++     +E+ Y   +    E +   + ++  H+L
Sbjct: 1105 PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 1160

Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
             N   RI  S+ +S +       Q  L++LQ    +     +E ++ S     +LE  VN
Sbjct: 1161 INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1220

Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
              K+ +    ++ LK  ERE Q              +  R+E+ E  L  ++  P+E+  
Sbjct: 1221 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1276

Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
            L         H+     F + + +++ + L  ++D +     I N+ EE  +        
Sbjct: 1277 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1321

Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
              L +  N++L+   Q   M+       D LK +   L + + A+   +   T L   + 
Sbjct: 1322 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1378

Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
             +A +N +     T+K    E+       H ++D   KAK +     K  K  D+ F   
Sbjct: 1379 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1438

Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
            +   D   E   N+      +L +  G G   ++  +    L+  I +     + IQ+ Q
Sbjct: 1439 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1498

Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
             + SK      T+    +++K L+  ++    + +E +++ ++ + ++   KD   +T+ 
Sbjct: 1499 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1549

Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
             +     ++    K+ V     Q    L +++++ + ++  T L+      +  Q     
Sbjct: 1550 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1599

Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
             ++LK+   E + ++EE  EH+E   ++ +   N+   L   +   +PPF K+       
Sbjct: 1600 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1653

Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
                +E+     E L  AL            I  +  K   KM     T+E+R  L++++
Sbjct: 1654 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1696

Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
            + + E     FS  + ++Q    S ++ +E +++             I + +   +  L 
Sbjct: 1697 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1756

Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
            G      +   T EL+    +  +  K   G  ++L + +  +++   E   KL +  + 
Sbjct: 1757 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1816

Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
            +++QK    L E +I C  L  +  + KK+ + V      +++       +L   + K  
Sbjct: 1817 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1872

Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
            N  DW SN+  + +                F+  + K ++ ++ +   + L         
Sbjct: 1873 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1932

Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
             T E  N + ++V    + ++   +  +      +++    GQ    E+ E + Q   KE
Sbjct: 1933 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1991

Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
            L+                  SLQ+ L   D D+     WL   E++ + +E   +     
Sbjct: 1992 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 2051

Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
               L R++   E V      L+    +    +    +C                      
Sbjct: 2052 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 2111

Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
               DR+++L  + + +    K L  + Q + D                       +A D 
Sbjct: 2112 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2171

Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
             +  ++++E+  +      +    E+++K  E++L     DAR   +  + +      +Q
Sbjct: 2172 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2220

Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
            KTL DI  ++++   L+ +     EKL +   + L  ++ L  ML     +E   K++  
Sbjct: 2221 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277

Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
              L        A   I  K +   QD+       +S  N + E  K    + +P      
Sbjct: 2278 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2323

Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
               SL  +++D          +H      + +L T +   +N S++  +F +     +  
Sbjct: 2324 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2383

Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
                   V E  Q +QE  +        L+ + +L K +  +     + ++ +   +L  
Sbjct: 2384 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2443

Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
            K K++E+ +   K+ +  C         ++KS +S  K+    +P  +      D+ +S 
Sbjct: 2444 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2503

Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
            +++   +KL+E W     EI K                    A+    S    LN + + 
Sbjct: 2504 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2560

Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
             NTE+          ++ + ++ +   +L  +L+++  E   KL    +A++ +   ++ 
Sbjct: 2561 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2620

Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
             + +NKT T         +         +A+ T +++NK               + E+ +
Sbjct: 2621 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2657

Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
            K  +   + LK    D +T L +         + K  L  +  KW+ L+    D  +KL 
Sbjct: 2658 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2713

Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
            ES     +       Q ++ +  Q +VE +   +++  +      L  Q+Q +Q+ L+  
Sbjct: 2714 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2767

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
              R             Q T  G  +L    E           +  +++ +  + ++W++L
Sbjct: 2768 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2812

Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
                 +  + I +  +++   +++L +      +L  +L+ S+ +   PD +  Q+   +
Sbjct: 2813 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2872

Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
                 I   ++ +   ++L E++   V     Y  ++L+  LE +   ++ +  K+    
Sbjct: 2873 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2930

Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
            Q L+        F  + R FQ  +   +            E + K H ++     LE+  
Sbjct: 2931 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2978

Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
            K+ ++    ++  +H+ E T     N+  +    E+  L+ QL  +K   +   + ++  
Sbjct: 2979 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 3038

Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
             N+++  ++   ++ E+   L    D  Q N  E+    +  +G              ++
Sbjct: 3039 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 3098

Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
             + + + L      +L V ++ K            ++D +  Q+  K+  LE   ++   
Sbjct: 3099 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 3158

Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
            F+E  +  K Q   +K   +D+     ++       +  ++++ + Q L  +++ AK L 
Sbjct: 3159 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3217

Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
             +++ + +++K   D      +LQ++  A+E+  L + +      L  K     + Q+ +
Sbjct: 3218 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3272

Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
                    +   +L     +  + + +Q +K+  +AF +++ A M S        K    
Sbjct: 3273 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3332

Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
                + D+    R+ E L  Q N  +D               L + Y  L  +   + +A
Sbjct: 3333 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3392

Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
             E   S      P  ++     + L M  + ++EE+E      QD+     G+I S    
Sbjct: 3393 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3448

Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
               Q    +L   N+  K   K     A +  E      + ++ + + LS M    E V 
Sbjct: 3449 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3508

Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
             Q   S    ++    ++++ K L   L   K  +  +++    +       D + +LK 
Sbjct: 3509 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3566

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
            +S L  +W +LL  A+      E +    +   E +E     L  +++ L   E   T+ 
Sbjct: 3567 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3626

Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
            +   E++++   L D +  + +++ +      + + +   + +  E    V++   F ++
Sbjct: 3627 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3681

Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
              +     ++ +K     EL+Q  +     F ++ + L N+  +       ++ QD+  +
Sbjct: 3682 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3736

Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
               +Q  EL+ + +   L  +N+ + L      +      E   I+ ++E  +   +DI 
Sbjct: 3737 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3795

Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
             K+S +V K+   +  + R++    EE+   L  VE  L        K +   +AQ   K
Sbjct: 3796 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3855

Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
            ++  E     + L+ L+     ++E  P +A+E ++ ++    ++Y+ VS     +  ++
Sbjct: 3856 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3915

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            + A ++ +++     +  +WI  T   L +  D      L    ++ Q+ ++ +     L
Sbjct: 3916 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3971

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
             H   +           D+L +S  ++    +  + Q + + L ++ +  D +  I SE 
Sbjct: 3972 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 4020

Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
                                    +   +  +S++    L  E      EEH +  E+I 
Sbjct: 4021 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 4080

Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
            E   +I  M KT  +++        P  G      +   + L   IK  E+V +++   L
Sbjct: 4081 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 4132

Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
               I Q+ ++ ++I+ + +         SLE +  ++  + P +  E+E++++QI     
Sbjct: 4133 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4178

Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
              +++ VD++  +  L++ LKQ  E
Sbjct: 4179 ENKNVSVDME-KLQPLYETLKQRGE 4202



 Score = 88.6 bits (218), Expect = 2e-16
 Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)

Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
            ++LS   G+ +QE++   + L              L+  I ++ +    I  +   + +I
Sbjct: 4097 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4156

Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
              +    P++ A        +   K   + ++K+   YE  K+  +EM A S    KD  
Sbjct: 4157 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4216

Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
             K V  +    V +WEN   LV E   +   V+EL +++  +  S++ T+   ++ +  L
Sbjct: 4217 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4276

Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
            +   +    +K++    E ++EE +   E +D +  +   L   +      ++P  +K  
Sbjct: 4277 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4333

Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
            + +   W  +N+  +D  + L  A+    +  +    + +W + A  K+        D E
Sbjct: 4334 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4393

Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
             +K++++  +Q  SE  ++  E++ L   +E+ L+    ES        L +++ +   L
Sbjct: 4394 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4453

Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
                 +  H L G   +  + +  LD+    +  TE LL    P        ++E  +  
Sbjct: 4454 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4513

Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
            +LQ              K    L+E+  G     L  +L  L +++++V +    +K  L
Sbjct: 4514 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4573

Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
                  +K  + + ++   W ++ + +L   K      ET K  EQ    +      E +
Sbjct: 4574 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4631

Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
                K +    + +    PK+    +   +   + + E +E+    R  +LE++L   + 
Sbjct: 4632 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4691

Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
              +  ++   WLT  E+       P           ++ ++F   +   REQ   + +  
Sbjct: 4692 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4751

Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
              LK   F++++++++    L+    R++ ++++L E            + F++    ++
Sbjct: 4752 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4809

Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
             W++E ++SL      + ++ +     KIK  +    E    +    ++      +   L
Sbjct: 4810 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863

Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
             +KT            L+++ ++WD     +    +  E+ LL   ++  + + L   L 
Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4923

Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
             ++ +      +   +      +  +K F K+    TS ++ LK     L+E ++ + S+
Sbjct: 4924 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4983

Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
             +    E+    E++          L+  +R+ + +   V  L   L    +        
Sbjct: 4984 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 5043

Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
            P D+ A+   + + +E   +L  +   L K       +LA+       T      II+  
Sbjct: 5044 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 5103

Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
             + +    K  + RLAS      AKQE +E  L  +  ++ +   K K  +P   ++  +
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5163

Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
             +       +E T++   V+K+ + ++
Sbjct: 5164 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5190



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)

Query: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            D+W+ I  + +  + K+++ L    Q    + A+  WL + E +L   +      DI  +
Sbjct: 4885 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4942

Query: 6590 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6649
               +   +   K      + V ++  S++E ++    +S+ ++ ++++LS  WE      
Sbjct: 4943 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 5002

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6708
             S +  L  +L Q ++FH +   LL WLA A+   R    + D +   R L++  +E M 
Sbjct: 5003 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 5061

Query: 6709 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              K+L E++ +++    + +++L   H +     +  + +I  + +++
Sbjct: 5062 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 5107



 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)

Query: 6548 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6604
            K+++ +Q   Q    + A+  W+     +L    M+   +D++ ++ +++ L++      
Sbjct: 4353 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4410

Query: 6605 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6662
              +  +  +N  ++  L+  TE  +   +Q  L +L L+W++ +  + + +  L  +L+ 
Sbjct: 4411 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4470

Query: 6663 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6720
               F      LL WL   +     QK    DPKA    L +       L+ +++  Q  V
Sbjct: 4471 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4526

Query: 6721 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6774
            + + +  N L+    GE+    + K+ V+ ++ + + E+  Q    L G    A
Sbjct: 4527 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4580



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 56/276 (20%), Positives = 107/276 (38%), Gaps = 24/276 (8%)

Query: 6504 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 6550
            K G  VLNG     N ++   + GL  I +  +     +E +      +  EL+ KL   
Sbjct: 2548 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2605

Query: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 6610
              LQ+   + SA+  WL+K        +    P+D + ++ +V++ +            V
Sbjct: 2606 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2664

Query: 6611 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
              +     E L+   ++PE+   +  L ++   W+         +  L +S      F  
Sbjct: 2665 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2724

Query: 6669 LSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEIS 6727
            +   L  WL     +     V  P   DP  L   R+++  L +E   R+PQ + L    
Sbjct: 2725 VEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2781

Query: 6728 NSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 6761
              +L +   +  +    +E++  + +K   L  Q+S
Sbjct: 2782 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2817



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)

Query: 585  LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
            L  W T+ E L    +    + K  EI+      L    L H +    +N+AGN L+E S
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4540

Query: 640  NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
                 S++  +L  LN+RW+ ++ KT+         +KQ           L    +    
Sbjct: 4541 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4582

Query: 700  FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
            F  ++     E+  Q +   E+H   ++   G  + AK  E+L   +E+  A EAK    
Sbjct: 4583 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4631

Query: 759  QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
                    EE+ K L+ KG  M       +E  +  DI N+  +E ++ V     + K+ 
Sbjct: 4632 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4676

Query: 818  EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
            E K K++                   L++ ++   S ++  +++ +A+Q L     P  +
Sbjct: 4677 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719

Query: 878  -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
                   I +HK     + S+ + + +  K    LK    +   + ++     V ++WE 
Sbjct: 4720 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4779

Query: 929  LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
            +       VQ+L   +E+G+  D+  K  KQ ++   KL+       K L  E E     
Sbjct: 4780 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4829

Query: 986  EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
            +    QL  H E  + L  +     +     R LK+
Sbjct: 4830 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4865



 Score = 43.9 bits (102), Expect = 0.006
 Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)

Query: 6541 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6600
            Q L +        QQ++ D  A   WL   + E           D+  +E  +K  ++  
Sbjct: 2931 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2985

Query: 6601 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6658
            K   T ++ +    ++  E   L+T+  E   LQ +L  +   W+     V      L++
Sbjct: 2986 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 3044

Query: 6659 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6718
            SL +   + +  + L  W+   +N  ++        DP        +L  L+KE+ +   
Sbjct: 3045 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 3101

Query: 6719 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6778
             V++L   +NSLL     +  +  +E   +I+ K+  + EQ+      L   +N      
Sbjct: 3102 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 3157

Query: 6779 SFDEV 6783
             F EV
Sbjct: 3158 EFQEV 3162



 Score = 41.6 bits (96), Expect = 0.028
 Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
            W+ ++ + ++ + K++  L    Q    +  +  WL  TE    +L   KP   D + IE
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4506

Query: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
            + + +   +      +++ V +VN +  + +++ +  E++ LQ++L  L+  W+      
Sbjct: 4507 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4566

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
            +  +  L  +L Q + FH   ++L  WL   +      H+   K     L E  +E + +
Sbjct: 4567 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4620

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6755
              E+       +  +E   SL+ KG                +D    +EK   +E KL +
Sbjct: 4621 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4677

Query: 6756 LREQVSQDL 6764
             + ++ + L
Sbjct: 4678 RKTKLEEAL 4686



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 17/259 (6%)

Query: 6554 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6611
            QQ +    A  +W+ +TE +L  L   +   D    +L+V++    EIL+  D    LV 
Sbjct: 3923 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3982

Query: 6612 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6671
            S     K        E   ++ +L ++   ++            L ++      F +  +
Sbjct: 3983 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 4039

Query: 6672 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
             L  WL   ++    + +  P  +   L + + E  QL + + E +P +D + +    LL
Sbjct: 4040 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 4097

Query: 6732 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL-----QGTQ---NPASPLPSFDE- 6782
                GE     +EK    +    Q++E V +  +AL     Q TQ        L S +  
Sbjct: 4098 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4156

Query: 6783 VDSGDQPPATSVPAPRAKQ 6801
            V+   QPP+ S    + K+
Sbjct: 4157 VERLRQPPSISAEVEKIKE 4175



 Score = 37.0 bits (84), Expect = 0.68
 Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)

Query: 6535 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6587
            W +   ++ H++ ++ Q    N +    D   +  WL +   +L  L +    ++    Q
Sbjct: 3682 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3741

Query: 6588 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6647
            + ELRV +   +L+  +  +AL+  + +      QT   E   +Q +L  +   ++    
Sbjct: 3742 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3797

Query: 6648 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6707
                    L Q+L   +  H   + L  WL   +           K +  +  + R +  
Sbjct: 3798 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3855

Query: 6708 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6760
            +L+KE    +  +D L E+S++LL        +G  +   E  E+  ++   + Q  E++
Sbjct: 3856 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3915

Query: 6761 SQDLMALQ 6768
               ++  Q
Sbjct: 3916 DAAILRSQ 3923



 Score = 36.2 bits (82), Expect = 1.2
 Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)

Query: 310  KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
            K+++++L K  +++ Y ++       ME  N + +  L  ++ + D   +    ++L+  
Sbjct: 4396 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4449

Query: 370  WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
            WD L+ +I   + KL  AL         L +  AWL   E L+ E      D  +A+ + 
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4508

Query: 423  ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
                  +Q  +   +S ++      N L+     +E ++L     NKLE + +R  N+LE
Sbjct: 4509 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4564

Query: 476  K 476
            K
Sbjct: 4565 K 4565



 Score = 35.8 bits (81), Expect = 1.5
 Identities = 33/191 (17%), Positives = 88/191 (46%), Gaps = 18/191 (9%)

Query: 6549 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 6605
            + QNL  +++N   +  +  W+ + + +L+  +     SD+  +E  ++  + + +A + 
Sbjct: 772  LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 828

Query: 6606 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQD 6665
            +++ +    +S    +Q  +P       +L +L    E+    + +      + L    +
Sbjct: 829  FESSLKEAKISE---IQMTAPLKLTYAEKLHRL----ESQYAKLLNTSRNQERHLDTLHN 881

Query: 6666 FHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLEKELVERQPQVDMLQ 6724
            F   + N L+WL    N +++  V    ++    +  +++   +L +EL +++  +  +Q
Sbjct: 882  FVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQ 937

Query: 6725 EISNSLLIKGH 6735
            EI+  LL++ H
Sbjct: 938  EIAEQLLLENH 948



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)

Query: 6624 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6683
            +S  +  L+  L  ++  W+     V      L+++L+ C  F    ++LL W+   +  
Sbjct: 3447 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3504

Query: 6684 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6743
               A+   P A+ + +    +E   L++ L +R+  V++++     +       D ++  
Sbjct: 3505 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3564

Query: 6744 EKVHVIEKKLKQLREQVSQDLMALQG 6769
            +++ +++ + + L  +       L+G
Sbjct: 3565 KQLSLLDSRWEALLNKAETRNRQLEG 3590


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  234 bits (596), Expect = 3e-60
 Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)

Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
            +N I + + S     K  LPG  +Q  S++Q       E +QES       + +LE++  
Sbjct: 983  INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1042

Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
            + K    E+  S +                 N +  ++N ED R + +++  PLE D + 
Sbjct: 1043 VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 1100

Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
             +  ++ E EKL  +LE  K  +  +     E  ++    +          +VL N+   
Sbjct: 1101 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1160

Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
               S+ ++D L    + LK N ++   +++ ++  L   E    A++ DK +++      
Sbjct: 1161 YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 1209

Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
               +  +K++ + +++++     L+ + +       +M K   E  +          QL 
Sbjct: 1210 -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 1268

Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
              W+ V  QI  +      + +     +   +DT   L    Q ++   +  +E     S
Sbjct: 1269 ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1324

Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
               L T L   K   S      E++MK+   ++ +K  E     +K             +
Sbjct: 1325 K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1377

Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
            +Q K    R +M+ +         +L      L   +    +  K   D +   ++  +S
Sbjct: 1378 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1434

Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
            L EE K+ V      +   S+++ TL+D     +    K    S+++  K E+ S     
Sbjct: 1435 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1494

Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
            I+ F                      +QES  L+    + +++ + T  ++K     +  
Sbjct: 1495 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1554

Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
             Q+E +E   GI   L +  N    +   E   + D   +LK  + +   +Q+ +Q +  
Sbjct: 1555 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1612

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
             +   +K    F      L+E  + + Q ++ L+ Q++N+  +K E  NLK        D
Sbjct: 1613 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1666

Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
            ++  TAIK        + Q+ + K   + + L+W  S +D+   +   K K++   I+Q 
Sbjct: 1667 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1721

Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
             T F+E  GK         AI  + +    ++    D    + + N   L+Q+ +K K  
Sbjct: 1722 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1770

Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
             ++II   ++++    + +  ++L  K    L+ EE +KL K ++ + +  E +  E ++
Sbjct: 1771 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1827

Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
            K     + Q++LE       + +  LQQ    L NLE     I  +  +    ++F E V
Sbjct: 1828 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1887

Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
             +    ++ +T    +              + + S+   +V+ KL    D    L +  +
Sbjct: 1888 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1947

Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
            +  N L D  +    Y++A    +  + + EA     +  P  VD  N +  LE     Q
Sbjct: 1948 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2007

Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
             ++ S    ++ L +   ++     S   AK  +Q TL ++V +   + ++   +  + +
Sbjct: 2008 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2067

Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
              L      +   +++   +  +E+ L +    +PL+     + + ++  L  ++   + 
Sbjct: 2068 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2126

Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
             +  + + ++        +    L   +  L  ++       KE     EELK + +   
Sbjct: 2127 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 2183

Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
                    + +NL E+L    +TK  A TE         ELS+ + +   ++ E+ +  +
Sbjct: 2184 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2235

Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
            +L +LL +   S   +P     V      ++  ++ ++  ++   +++ KE V +  ++ 
Sbjct: 2236 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2288

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
             +F   + +LK++ ++TT     +      E   +  E+ + + +K  L    I +    
Sbjct: 2289 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2348

Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
             I    + + V  PA+  + V+     L       + +E  +N+ L S        S  Y
Sbjct: 2349 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2408

Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
                  ++ KI E+N  L  ++K  ++ S  ++  Q++ K    W               
Sbjct: 2409 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2468

Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
                     EL    +K+ EL  ++ +++E++P   +A  W   L     ++Q+++Q   
Sbjct: 2469 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528

Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
             R  +L +++  + ++  +    + W+     +++   P   D    L+     VQ+ L+
Sbjct: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2587

Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
            +   +      +    +  LS   E   L   ++E    VT     +   L       D 
Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2647

Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
             +   ++ +S+ + +S   + L +K     +   H       LE  + MK+ I       
Sbjct: 2648 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2700

Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  Q   K + V Q   + L  +   E +  E +  L+ ++K   + +++ EN  Q 
Sbjct: 2701 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2754

Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
            L +  A     + MS D    L   + E  +       L+   E L+ D K  +  L   
Sbjct: 2755 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2813

Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
             H+ ++      + L      E    +   +  K N       +   E +++ES  K+  
Sbjct: 2814 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2873

Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
              E+ E     W  + K   ++EE +                +  +NS+A++    SL  
Sbjct: 2874 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2916

Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
            E      +    N T        E D    +D    L  +V+      TE LH+ K  + 
Sbjct: 2917 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 2972

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
             +                    Q+  E Q         E+  +    L+  K+Q  + D+
Sbjct: 2973 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 3004

Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
              +Q  +      L+T + +L+  K Q+ L ++ ++D    ++ ++S+ +    +    L
Sbjct: 3005 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 3056

Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
             ++E+I  E    S+Q D ++   LE K      F   I    ++M+ Q+ + D++    
Sbjct: 3057 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 3110

Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
                              ++P G++ +  Q     + + +K      +E  +++N     
Sbjct: 3111 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 3147

Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
            +  M      T+ +L      LE L ++ + L  +    EE      K+L E +  L + 
Sbjct: 3148 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 3206

Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
                  +L+    + E      +  ET+  +L    +   ++   L    + + W G+  
Sbjct: 3207 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3263

Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
                    +T  L    D++    +        R+  L+  L +   +Q+ ++ L   ++
Sbjct: 3264 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3323

Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
             ++  +  Q       + V  Q+Q+       L++ +S V  ++ EGE++        +V
Sbjct: 3324 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383

Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
              L+ +  LDS W  L      R  +L    V   Q    L+ + E +   +++L +   
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443

Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
                     +Q     AL+  I NH     + V+    ++  S++    ++Q++  F   
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3501

Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
            QV  ++I +EKS      LQ  L   + F E+   L   L  +   L  +S+ + + E L
Sbjct: 3502 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3560

Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
             ++ S  + ++ +I  +   + Q L  G +L+   +  E   ++ ++  ++ ++  + K 
Sbjct: 3561 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3620

Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
                   L+  L+     +   ++L  WL+  +  L  ++ Q L   +     +R     
Sbjct: 3621 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3677

Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
              E  KE     +L  ++  + + LL L        L   +A+  +++ ++   +    E
Sbjct: 3678 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3735

Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
            ++    +      +A    +SW+   E +      +      +  +  LQ  K F ME +
Sbjct: 3736 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3793

Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
             +K  I D V      ++ C  E K+  + +  + L           E   Q  R   ++
Sbjct: 3794 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3853

Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
            N+  +  E+L   +TE+++ I    + L A     +TL Q+ E    +++L+ + +   +
Sbjct: 3854 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3909

Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
            ++      L EL        ++ Y+  ++    + ED   R   +DE   + +    +++
Sbjct: 3910 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3969

Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
            Q+  S++ +++  +    +  EV  +  +    +  +K V + +E L+   E L+   +E
Sbjct: 3970 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 4025

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
              +  G  +K               A+ +++K       W  ++  + ++  K   +++L
Sbjct: 4026 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4073

Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
             + +   H      +K  +   + L +  +  + + +    A + I+E    +Q+  +  
Sbjct: 4074 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 4132

Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
            +   S L        +P    +   L     SL +A       LE+ +            
Sbjct: 4133 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4192

Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
             F++V      L+     G  LE++K  I   ++     +QQ+ E     LNH   L   
Sbjct: 4193 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 4248

Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
               ++ + E S K  + D     L  +   W       + R  +L+G  L   +F +  +
Sbjct: 4249 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301

Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
            + +  L   E  L         P+ +E +   + +L+ +V  +Q+  ++       L+++
Sbjct: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4361

Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
            +  E       +   L  RWQN ++   QRK  +DG +RQ + F   +E+L ++LTDT  
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421

Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
             L A K      L        E  N  +     F+ +  T    ++ G+++L       +
Sbjct: 4422 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4476

Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
             ++ + I+ L++ W+ +E +L E   + +  +    E  +  +  I  L    Q L   S
Sbjct: 4477 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4536

Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
               L  + + +  + +  K     + S  + + EL      L      +DV+++K  +  
Sbjct: 4537 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4594

Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
            +  +WE +  R+  R + ++D       F+E   +L  WL + E  +    +I+ +    
Sbjct: 4595 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4654

Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
            K Q    K+  + +           + G  L  K S      ++DD L+++ D+W  +  
Sbjct: 4655 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4714

Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
                R  KL+E   F  Q    +  L  WL R+E +L+  +PV  D+     +   +   
Sbjct: 4715 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4771

Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
            +  Q+++ + ++ V+++      L+  S       +   ++   + L  RW  +CA+S+ 
Sbjct: 4772 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4826

Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
            ++ ++E   R  ++F        +WL  AE+T       P+  + L T     + + + F
Sbjct: 4827 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4882

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
             +++ E+  +L         +      D+ + +K  +     R++ +        +RL  
Sbjct: 4883 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4942

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
                    +   E++L WL   +  LT+ +        ++++ L      F +E+T    
Sbjct: 4943 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5002

Query: 6299 KIDQL 6303
             +D++
Sbjct: 5003 DVDKV 5007



 Score =  198 bits (504), Expect = 1e-49
 Identities = 116/287 (40%), Positives = 157/287 (54%), Gaps = 35/287 (12%)

Query: 7   LPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHV 66
           L  E+++     +D+    + E++  QKK FT WIN  L +      ++DL+ D++ GH 
Sbjct: 11  LYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHN 68

Query: 67  LLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILG 126
           L+ LLEVLSG  LPR+KG   F    N++ AL +L+ R +KL+NI   DI DGNP + LG
Sbjct: 69  LISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLG 128

Query: 127 LIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKA 186
           LIWTIILHF I                 D+ V   S                  MSA++ 
Sbjct: 129 LIWTIILHFQIS----------------DIHVTGESE----------------DMSAKER 156

Query: 187 LLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAF 246
           LLLW Q+    Y  +   +F + WR+G  F AIIH  RPDLIDM +V  +SN  NL  AF
Sbjct: 157 LLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAF 216

Query: 247 RIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGE 293
            +AE ++ + RLL+PEDVDV  PDEKS++TYV+         P  GE
Sbjct: 217 YVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGE 262



 Score =  193 bits (490), Expect = 6e-48
 Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)

Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
            N  EE  N  FV   L+  D   +Q    ++ +    +   ++  ++  +A+E+F +SL+
Sbjct: 597  NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 656

Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
             AK+          S+ Q+     LT   K   +H ++       +  K+L+ S ++ ER
Sbjct: 657  EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 696

Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
              DT    +  A +  I L+E     V  +++E N  +      + EL++       NI+
Sbjct: 697  HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 756

Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
             VQ    ++ L++    +    +R     +   +L   +  ++H++E       F D +E
Sbjct: 757  SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 816

Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
             T               C  +  +    + LV E +E+   +L+      N      T+I
Sbjct: 817  ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 875

Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
            Q     S   L+ S   K     R  EI I K++      N H     K   +       
Sbjct: 876  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 932

Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
            +     F  PP  KEA       +D+  + E  Y+N+   L LW +   N+K+V+  W  
Sbjct: 933  MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 980

Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
                    + + E DR R      +      E  + ++ +Q   +   E   E QV   S
Sbjct: 981  --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 1032

Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
             + ++E  V  C               +  ++L ++  +    ES+   L  S+   I  
Sbjct: 1033 DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 1077

Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
            +LE  + ++++Q  + +    L   +  +T E  +LKK+ E + D   T  +  ++ FS+
Sbjct: 1078 RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 1136

Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
               +          + +  N+ + +  S T                      K+K V+ V
Sbjct: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 1177

Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
            LK+ +  + L K +  +L     ++  +  +E + S  +    E+++  Q    L+D+  
Sbjct: 1178 LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 1235

Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
             L+K     +E +K  +E     +   +   +  E++++V  Q++N L++  G  +  + 
Sbjct: 1236 -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 1294

Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
              +    +D    + +T  R++ E + E  K L T+      L  ++     E+K+S M 
Sbjct: 1295 YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1348

Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
                E +   E+    +K+  L      A +++     + ++   S A L+ +   D+  
Sbjct: 1349 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1405

Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
            ++   + L + Y          L  +EK L E +K +++  ++L+  +      LK  ++
Sbjct: 1406 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1465

Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
            AG       +    ++   K+ L +A     L   L   G+ + +  +N    +   L+ 
Sbjct: 1466 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1523

Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
             +  L    L+QLQ+S  + D  V         +E+      + DL T  +N     +E 
Sbjct: 1524 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1583

Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
                D  V+    + K ++LQ+         G+ + +  + K+ +      G+K+ ++D 
Sbjct: 1584 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1636

Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
            K+L      +E +L  AK +   C    LK+++S ++         +K  T+ ++E T++
Sbjct: 1637 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1679

Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
             AAV++LEE         DW  N D   E A +K   +  Q          +S    EDE
Sbjct: 1680 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1739

Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
               N L+    ++D  +   Q E + + Y +++A+   I    Q   +  T++  ++L  
Sbjct: 1740 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1794

Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
             G   S +  + L + +  LK + E+           LA  E  MK   + +E L+    
Sbjct: 1795 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1844

Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
            D   +   L + ++ + ++E   D +  L  K        E++ +H      +T    ++
Sbjct: 1845 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1904

Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
            LE+     +    +V+     +++Q+K       +    +  N + +    L  + QH  
Sbjct: 1905 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 1964

Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
                 L   L++ E  A       +  D   LQ        L+GQ   Q   +   K+  
Sbjct: 1965 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 2024

Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
                         K +++  ++++  ++E L     E   ++     +   +++ + E +
Sbjct: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084

Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
             W  N+   L     +PL    +   I K  +    I  RQ S+ ++ E+VK  + +   
Sbjct: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144

Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
               S L   ++DL  ++     K  +   ++E +L+ +   F  + +      E++T  +
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 2203

Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
              V+    +            +E   H   LE     L+EI S G+ +   +   + E+ 
Sbjct: 2204 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 2260

Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
            N   + F  +ED +K  K      Q  +      V+    + ++  +K   +Q       
Sbjct: 2261 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 2320

Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
                 E+   +Q    L   E+    N G+   + NL   +T     I  V     V + 
Sbjct: 2321 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2378

Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
             G          N   + + +  T +    ++    L++KI +L+T   +  K Q    +
Sbjct: 2379 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2435

Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
              A+   ++KM +   K           A  +  E  +     L Q + K + L D++ +
Sbjct: 2436 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2495

Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
             L EN    ++ + K++L       E D  ++ L  + ++   K  +  N   + +T   
Sbjct: 2496 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2549

Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
             L Q  ++ +L   +L  ++++   +  ++   +   ++        + +TA    I  +
Sbjct: 2550 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2609

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
              E+ S    V+ +L         L   +  R + ++ A    T+Y+  +    + ++ L
Sbjct: 2610 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2669

Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
            +     ++ +    D  N  + LE   + ++E++     I   Q L E L       A +
Sbjct: 2670 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2721

Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
            + +Y   EL  +   + ++FK  E +AE ++++ +        +++M  D     + ++T
Sbjct: 2722 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2778

Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
               +   S P+S + + LE L     + SK L +     ++ + +   +  LL+ + +E 
Sbjct: 2779 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2836

Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
              + L L  +   W+                     K+   +E    W   C+   +E K
Sbjct: 2837 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2896

Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
            F  +  E E  I  L +LQ+E+ +                 + +  +   T+E   L+  
Sbjct: 2897 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2956

Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
            +    E +  ++  L  + Q+ +  Q V + S      A E +     + S     +   
Sbjct: 2957 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3016

Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
            +LQ  QK+ + ++ ++       ++++   +  + T+     +    Q+H   S+Q +E 
Sbjct: 3017 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076

Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
             S L+   +G   F+N + ++  +++E    +   A +    E  +K  E I   +   E
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 3136

Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
             L +S   A     M    EE +  L     ++E + +Q +K +++AQ  ++++      
Sbjct: 3137 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196

Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
            L+ ++SKL E    +Q   E +  Q    M+   I                P Q  QQ  
Sbjct: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256

Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
                                             ++++   R +QL +A +    + D L+
Sbjct: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316

Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
            S  +W+ +T  L+AN     A++  ++        +Q  L+D   + + +  I  + E +
Sbjct: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3373

Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
            +   E  +  + +++LS   ++  AL  K      Q++ ++         ++ + + ++ 
Sbjct: 3374 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3433

Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
            I+  L++ E         EE +   + + ++I    K + + VS    L++  +      
Sbjct: 3434 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3493

Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
            V  + +        ++  +  ++ELL+  +     + E+   L   LN    + S   + 
Sbjct: 3494 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3553

Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
                + L + Q E+  +++ IL   Q  +  L++    LK T  +    ++ + E + + 
Sbjct: 3554 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3612

Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
            R   +T     VA+      +L RR         ++L  VE E+     +   G+E  +A
Sbjct: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672

Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
            +  P+      K++K + +     SS  +       +E   K+   DN   ++++   + 
Sbjct: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732

Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
              E+     LR  Q ++            ++DA+       EK               + 
Sbjct: 3733 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3769

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            ++ L   Q +  ++       +Q+    +++  + ++ ++      ++  C ++      
Sbjct: 3770 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3816

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
                E +++  KL  V  N + +  +  E++ + +    L       ++E L P  L+E 
Sbjct: 3817 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3870

Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
            +SI+++ P      +  RQ+  + +Q+ EL   E K  I        K  PQ  +    +
Sbjct: 3871 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3925

Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
              + QE   +A    S  + DV       D  +S   Q  DK   +   L   + +L  P
Sbjct: 3926 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3985

Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
                   + ++ Q+S N  +   +      Y T ++                  K    +
Sbjct: 3986 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 4045

Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
            L+ +     N+ T     E   ++   L +K +     L +T+      + + LE P + 
Sbjct: 4046 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 4104

Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
                  QQ   ET+  E+  L   L    +   +L+ A   P  +  ++ +  D L    
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 4162

Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
            +    A   R   L+  +     YQ+ ++ ++  +      + S + +   L  +  Q  
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 4222

Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
              +  K++AY  ++E       AE  + K+ +E ++    + +   + +L+ + DS+   
Sbjct: 4223 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 4278

Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
            +  R  +L    +   Q Q AL + +  L      + ++K   G  K  + ++A    ++
Sbjct: 4279 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4338

Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
            N  +  Q  V     A   LI++ SA    S LQN+     ++   V    EK+ Q   +
Sbjct: 4339 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4394

Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
            L   L++ + F      L++ L      L+++ P   L E  +E+L    + + ++    
Sbjct: 4395 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4450

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
              K       + +G+Q++A   CP+     ++  I  L+E+W S+  K++    +L+  L
Sbjct: 4451 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4508

Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
               + ++        WL  ++ TLN     SL     LDT+   I+    F+ EV   +S
Sbjct: 4509 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4561

Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
             +  +I +     HLK    + D   ++  L   + +W  ++ +L +    L   +    
Sbjct: 4562 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4621

Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
               +A ++++ W+   E + S +  +   +   ++K  L +HKEF+  +  K  + D  N
Sbjct: 4622 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4679

Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
            ++   L   +  S   +  +  + L E+  +W  + G    +   LE+ L    +  + +
Sbjct: 4680 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4737

Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
            Q L +WL   E +L   Q     I  V  L+ + +  + +L  ++ ++  LK+S   L  
Sbjct: 4738 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4797

Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
            G+     D +S +    Q+ S+    V  L  S Q+ L+      + +  V    + +  
Sbjct: 4798 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4851

Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
             +  ++  +     L    + L++L D+ +      E+ +  + K   +  +V  I    
Sbjct: 4852 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4910

Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
               T K W  + +A  +++       Q   A + A   A   L +    + Q A  +++ 
Sbjct: 4911 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 4970

Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
             +  E++P  ++++K L  + Q   E   +    +D++
Sbjct: 4971 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007



 Score =  183 bits (464), Expect = 6e-45
 Identities = 676/3660 (18%), Positives = 1402/3660 (38%), Gaps = 447/3660 (12%)

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
            +E L+   R+++E      +I ++      + + E +L  Q  ++  + ++   +  F+ 
Sbjct: 1049 QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ--IRTPLERDDLHESVFRI 1106

Query: 3350 QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPL-SYREALERLEQSKALVS 3408
             E E  +     K   ++++D+ T  +K E    Q+ +S  + + R  L  + Q+   V 
Sbjct: 1107 TEQEKLK-----KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161

Query: 3409 NLISTKEELMKLRQIL--------RLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEW 3460
            ++ ST  + +K   ++         L++L  T+   +C  + V A      +L+   K+W
Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK---LCEEEAVIADKNNIENLISTLKQW 1218

Query: 3461 EMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGEN 3520
                +E +Q +  + +E+++   I D + +   E          +   E  D L +  +N
Sbjct: 1219 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE-----RDLDFDWHKEKADQLVERWQN 1273

Query: 3521 VEKQQLLLTLLLQRIRSIQNVPESSGAVETV--PAFQEITSMKERCNKLLQKVQKNKELV 3578
            V  Q      +  R+R ++ + +S         P    I  ++    K+ +   +N + +
Sbjct: 1274 VHVQ------IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1327

Query: 3579 QTEIQERHSFTKEIIALKN-------FFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKG 3631
             T++ ++     EI   ++       + +Q + + ++   Q    ++    + +S +K+ 
Sbjct: 1328 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1387

Query: 3632 K------LTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPS 3685
            +      L  +  M+ LR +Y+ + T++   I+   +  ++  E+  EK   E  K    
Sbjct: 1388 RMQSSADLIIQEFMD-LRTRYTALVTLMTQYIKFAGDSLKRLEEE--EKSLEEEKKEHVE 1444

Query: 3686 YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQ--- 3742
                 K +E+   + N+ K L+   K  +     QK   +E+     +L+E    +Q   
Sbjct: 1445 -----KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1499

Query: 3743 -----DIVEQDPGQAQEWMDNLMIPFQQY--QQVSQRAECRTSQLNKATVKM-----EEY 3790
                  + +++  + ++ +  L   +     + + Q  E +TS   K   K+     +EY
Sbjct: 1500 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEY 1559

Query: 3791 SDLLKSTEAWIENTSHLLANPADY----DSLRTLSHHASTVQMALEDSEQKHNLLHSIFM 3846
             + L+     +  T + L    +     D    L  + S  +   +D +     L  +  
Sbjct: 1560 KEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVK 1619

Query: 3847 DLEDL-----SIIFETDE--LTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESE- 3898
            + E+        + + D+  + Q + E   +   L  K  +S  ++ ++    +  E+E 
Sbjct: 1620 NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1679

Query: 3899 ---VKSMEKRVSKIKTIL--LSKEIFDFSPEEHLKHGEVILENIRPM-----KKTIAEIV 3948
               VK +E+  +KI+ +L  LS    D S     KH +VI +N         K  I E  
Sbjct: 1680 VAAVKQLEESKTKIENLLDWLSNVDKD-SERAGTKHKQVIEQNGTHFQEGDGKSAIGEED 1738

Query: 3949 SYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLEN--VTQEQNELL-----KVVIKQTNEW 4001
                 L       +     +  NQ  Q +K      ++Q Q  ++     +V++++  ++
Sbjct: 1739 EVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY 1798

Query: 4002 --DEEIENLKQILNNYSAQFSLEHMSPDQADKLPQ-LQGEIERMEKQILSLN---QRKED 4055
               EE E L++ +      +       ++  KL   LQ E+E+ +          Q+ E 
Sbjct: 1799 LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1858

Query: 4056 LLVDLKA---TVLNLHQHLKQEQEGVE-----RDRLPAVTSEEGGVAERDASERKLNRRG 4107
             L +L+A    +  L   LK+++   E     +  L  +T     V E   S  K  R G
Sbjct: 1859 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSK--RDG 1916

Query: 4108 SMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEE--DRASSSSGTIVQE 4165
                 +A   EV+    K D+  ++        + L  + KD+ +       +S  ++  
Sbjct: 1917 GKVDTSATHREVQR---KLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAG 1973

Query: 4166 AYGKISTSDNSMAQILTPDSLNTE---------QGPECSLRP-----NQTEE------GT 4205
                 +T+   +++ +  D  N +         QG   S +       +T E      G+
Sbjct: 1974 LQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS 2033

Query: 4206 TPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQ-------VAELELWLQQANVA 4258
              P + D   + D   G    + K+  E  E L    T+       + E+  W+     +
Sbjct: 2034 LLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESS 2093

Query: 4259 VEPE---TLNADMQQ-------VLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGAT 4308
            ++ +    LN+   Q       +LEQ + G Q+ +  +  KV   +ET            
Sbjct: 2094 LKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS-------- 2145

Query: 4309 QHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSE-LE 4367
               A +L  K+K +     +       KH E    T+ K        E  +  NLSE L+
Sbjct: 2146 --TASSLQAKMKDLSARFSEAS----HKHKE----TLAKMEELKTKVELFE--NLSEKLQ 2193

Query: 4368 SIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAK-----KMWPQYCQHD--NDT 4420
            + +  + Q   + D   + V EL    Q+   +F+E          +  +   H   +D 
Sbjct: 2194 TFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2253

Query: 4421 TQESSASNQASSPENDVPDSILSPQG------QNGDKWQYLHHELSSKIKLPLPQLVEPQ 4474
                  +N  S    ++ D+I   +       +  D +Q L   L S IK    ++  P 
Sbjct: 2254 ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PI 2311

Query: 4475 VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNL-QTQENMTEEAYINLDKKL 4533
            V  + G               E+    T +++ +     +L      +T  A      K 
Sbjct: 2312 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2371

Query: 4534 FELFLTLSQCLSSVEEMLEMPRL--YREDGSGQQVHYETLALELKKLYLALSDKKGDLLK 4591
                L      ++ EE      L   ++D +     YE L L LK     L+ K   L K
Sbjct: 2372 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK 2431

Query: 4592 AMTWPGENTNLLLECFDNL-QVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
            A     E ++ +++    + +   +  Q  A   ++++K  ++ N+S++ E+K+  +++ 
Sbjct: 2432 AQ----EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2487

Query: 4651 KSKTSLQQSLNEISGQSVA----EQLQKADAYTVELENAE-SRVAKLRDEGERL---HLP 4702
            + K  L + L E      A    + L + D+   EL      R  KL +    L      
Sbjct: 2488 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2547

Query: 4703 YALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA--- 4759
             A L++    ++++ S+ G L      L+    T+ QQ  +L       K   E+L    
Sbjct: 2548 EAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKPQYEQLTAAG 2603

Query: 4760 HGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
             G L +     +L+            +V + L         L   L +R   W +Q    
Sbjct: 2604 QGILSRPGEDPSLRG-----------IVKEQLAAVTQKWDSLTGQLSDR-CDWIDQAIV- 2650

Query: 4820 KILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVE-ETEERLVERI 4878
                 KS Q    L+SL  K  + D   +S      + +ST P     + ET +++ + I
Sbjct: 2651 -----KSTQYQSLLRSLSDKLSDLDNKLSS-----SLAVSTHPDAMNQQLETAQKMKQEI 2700

Query: 4879 SFYQQIKRNIGGKHARLYQTLNEGKQLVASVSC--PELEGQIAKLEEQWLSLNKKIDHEL 4936
               QQ K+ I     ++ Q L E    +        EL  Q+  + + +  + +K ++ +
Sbjct: 2701 ---QQEKKQI-----KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHV 2752

Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
              LQ+       + + S     WL++ +   N    +S  +S  LD + S I +  +FSK
Sbjct: 2753 QHLQSACASSHQFQQMSRDFQAWLDTKKEEQN----KSHPISAKLDVLESLIKDHKDFSK 2808

Query: 4997 EVDEKSSLKTAVISIG-NQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
             +  +S +    I+ G N LL  + ++ A L+  L   +  W     Q+ + + KL +  
Sbjct: 2809 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2868

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
             + L  ++ +  +  W++  ++   +      P+     ++ + K K  + EMD    +V
Sbjct: 2869 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG---ENSIAKLKSLQKEMDQHFGMV 2925

Query: 5116 DFVNQ---SLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESI 5172
            + +N    SLL +   D E    E     + +  +  Q H     L    Q  ++  E  
Sbjct: 2926 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 2985

Query: 5173 TESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQS 5232
             ES+ ++Q     L+  +         + +  +Q      Q +++Q+ +  +   +L   
Sbjct: 2986 KESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL--- 3042

Query: 5233 YLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMM 5292
               +E+       D   +++ + Q+ S++  QV++  + +++ LQ    +     E+   
Sbjct: 3043 --VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3100

Query: 5293 TIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---SEGSWEKLQEVIGKLKGLCP 5349
               F   ++   PV    ETL+ Q E +++   + E+   S  +  K  +++   +   P
Sbjct: 3101 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 3160

Query: 5350 SVA------EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQ 5403
             +       E + ++C     R     + +   +++ +      K +S    +A    + 
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3220

Query: 5404 QEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESS 5463
            Q     +   I+   N         ++ ++  Q DV    +  +Q++         A+S+
Sbjct: 3221 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA---------AKST 3271

Query: 5464 THMLLPGPLHSLQ-RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDR 5522
            +   L   L  +  R   L K +  +A + +  L     F   LESL   ++  EE +  
Sbjct: 3272 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3331

Query: 5523 LHQQEKE--------NPDSFLNHVLALTAQSPDIEHLNEVSLKL-----PLSDVAV-KTL 5568
                  E             L  +L    +   +E +     K+     P   V + K L
Sbjct: 3332 QKPPSAEFKVVKAQIQEQKLLQRLL--DDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3389

Query: 5569 QNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEALK--VDVANSLP 5625
              ++ +W      A  R  +L+GI +  ++F    E   + L  IE+ L     +     
Sbjct: 3390 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3449

Query: 5626 ELLEQQKTYKMLEAEV-----SINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
            +L EQ   +K LE ++      ++Q ++   + QSL++L + E ++  +   +FS++   
Sbjct: 3450 KLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDFSQV--- 3503

Query: 5681 WQNAVQGVRQRKGDV-DGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFS--LYQT 5737
            W   +Q     + ++    +   + F      L  +L +    LS +  Q+  +  L++ 
Sbjct: 3504 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3563

Query: 5738 RSLIHELKNKEIHFQRRRTTCALT--LE-----AGEKLLLTTD-LKTKESVGRRISQLQD 5789
            +S +  L+ ++I  +++    AL   LE      G+++L+  D L+  ++  + I++L  
Sbjct: 3564 QSELRVLQ-EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3622

Query: 5790 SWKDMEPQLAEMIKQFQSTVE---TW-DQCEKKIKELKSRLQVLK----AQSEDPLPELH 5841
                   Q  ++ ++  ST E   TW D+ E ++  L    QVLK    +Q++    EL 
Sbjct: 3623 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL--LSYETQVLKGEEASQAQMRPKELK 3680

Query: 5842 EDLHNEKELIKELEQ------SLASWTQNLKELQTMKADLTRHVLVEDVMVLK-EQIEHL 5894
            ++  N K L+  L +       L  W       + +  D  R+ LV D +  K E+I+  
Sbjct: 3681 KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-- 3738

Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEK 5954
                        +R Q+          F++      +W+ + E K++   DI +E+    
Sbjct: 3739 ---------AAILRSQQ----------FDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3779

Query: 5955 LQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-------EIDDKLNKINDRWQHLF 6007
             Q   ++    F+   L+ K + D L+K+ +K   A        +  KL+K+   +  + 
Sbjct: 3780 AQ---LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTIC 3836

Query: 6008 DVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ 6067
             +   R  +L+   + + Q  +    L  WL   +S +S+ +     + + ++++  E +
Sbjct: 3837 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPALEYETLRQQQEEHR 3895

Query: 6068 DLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMER 6127
             L+  I +H   ++ +      LL  S       E  SIQ+   + D  +  I     +R
Sbjct: 3896 QLRELIAEHKPHIDKMNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKEDVKKR 3950

Query: 6128 RMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIH 6187
             + ++E      +F D   +  + L+        P S        KE++   +     + 
Sbjct: 3951 AVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME 4010

Query: 6188 ERLTQLELINKQYRRL-ARENRTDTASRLKQMVHEGNQR---WDNLQRRVTAVLRRLRHF 6243
            +     E + ++   + AR   TD     K +  + +Q    W+N+   V     +L   
Sbjct: 4011 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4070

Query: 6244 TNQREEFEGTRESILVWLTEMDLQLTNVEH--------FSESDADDKMRQ-LNGFQQEIT 6294
                E+F     S++V + +    + ++E           + +A + +R+ ++G Q+E+ 
Sbjct: 4071 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 4130

Query: 6295 LNTNKIDQLIVF----GEQLIQKS--------EPLDAVLIE--DELEELHRYC------- 6333
            +  N   +LI       + +++KS        + L+    +  D+LEE  +         
Sbjct: 4131 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4190

Query: 6334 QEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPS-SPQS 6392
            Q VF  V     +L S +P   D +   +    +E+ ++ ++++++++ E E  +   + 
Sbjct: 4191 QAVFDWVDIAGGKLASMSPIGTDLETVKQQ---IEELKQFKSEAYQQQIEMERLNHQAEL 4247

Query: 6393 LCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGH 6452
            L   V    ++   + P+    + L WD   +   +  H+          L G  ++ G 
Sbjct: 4248 LLKKVTEESDKHTVQDPLM--ELKLIWDSLEERIINRQHK----------LEGALLALGQ 4295

Query: 6453 SWHVPDSPSCPEHHYKQMEGDRNV----PPVPPASSTPYKPPYGKLLLPPGTDGG--KEG 6506
              H  D       H + +  ++      P         +      +L    T     K G
Sbjct: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4355

Query: 6507 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQ---LNSDISAI 6563
              ++  +  +E   L    E  +    RW+ +  +    K ++   L+Q    + +I  +
Sbjct: 4356 NDLIESSAGEEASNLQNKLEVLN---QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDL 4412

Query: 6564 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 6623
              WL  TE  L   K      +  + +L V    E+  AF+  +    S+    ++ L  
Sbjct: 4413 QQWLTDTERHLLASKPLGGLPETAKEQLNVH--MEVCAAFEAKEETYKSLMQKGQQML-A 4469

Query: 6624 ESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6681
              P+S E  +   +  L   WE+ +  ++  +  L ++L    +FH   Q+ + WL  A+
Sbjct: 4470 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4529



 Score =  181 bits (458), Expect = 3e-44
 Identities = 668/3660 (18%), Positives = 1377/3660 (37%), Gaps = 503/3660 (13%)

Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
            E +LEN+K   +  E+  ++L + +    Q  + L L+Y E L RLE   A    L++T 
Sbjct: 635  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 691

Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
                +    L     R T             +W       E A +W      + ++ K  
Sbjct: 692  RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 740

Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
              E+ RE   LD  +E +  + +  E    E     L  +  Y   ++ Q   +  L Q 
Sbjct: 741  HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 796

Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
            +   Q++ E++   E     +E T         +Q+         + K ++LVQ  ++E+
Sbjct: 797  VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 854

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
                +    + N   +  T  Q       P  S+          K  +  + I +  +I+
Sbjct: 855  EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 902

Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
                 TI   +         +A   +     NE +  S  +     +   N    ++   
Sbjct: 903  I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 954

Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
            ++Q+ +N+             +  WH  +NE+D    S V  I    PG+ Q+ + NL  
Sbjct: 955  IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1014

Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
             F+ + + SQ ++  +    +QL K   V  + Y +LLKS E   +  S      ++  +
Sbjct: 1015 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1074

Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
            +R  L +    +   +    ++ +L  S+F   E   +  E + L   +  ++N+     
Sbjct: 1075 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1134

Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
             Q     S+P ++   + V+   ++V SM    + K+KT+ L      + E      E  
Sbjct: 1135 SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 1194

Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
            L   E ++ +   ++  I+ +  ++ E+       +   VF      LQ  K + +    
Sbjct: 1195 LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 1244

Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
              E+ K   ++  ++D   E   Q++  +       H+  D  ++L  L+G I +  K  
Sbjct: 1245 --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 1295

Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
                   +D +  ++ T     + +++ Q    +     +  ++  V+E +  + K++  
Sbjct: 1296 RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1351

Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
            ++ +  Y A V++ E++  + ++    ++  P              ++  R  SS+  I+
Sbjct: 1352 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1397

Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
            QE +  + T   ++  ++T       DSL   +  E SL   +                 
Sbjct: 1398 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1456

Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
                   E+   PP     + S +     E   E                T  E  E+  
Sbjct: 1457 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1516

Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
              KT      L   ++           +V VE E + A+ QQ  +++L G   +LT+ E 
Sbjct: 1517 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1575

Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
                H+ AF++     E  K Q   +    Q + +  +  L  V  N E       EK S
Sbjct: 1576 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1633

Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
            ++    I +K +E + +   + +NL       EL+ +VT   +   +K    +Q+ E K 
Sbjct: 1634 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1691

Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
              +   D++  ++ ++++   ++ Q    N T  +      A   E++V          N
Sbjct: 1692 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1741

Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
            G+                   L+E  V   +G                     TTQ E+L
Sbjct: 1742 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1760

Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
             Q+   ++ Q    +++   + +  +  ++ L       S EE  ++ +  +E     +V
Sbjct: 1761 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1816

Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
            HYET         LA S+KK  L  ++          LE FD      EH    +    +
Sbjct: 1817 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1861

Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
            +L+AG D       ++KR       +I  K  L+     ISG  V   A+   K D   V
Sbjct: 1862 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1919

Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
            +       V +  D   +R    Y+    +   L+D++D         Y + S   +   
Sbjct: 1920 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 1974

Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
            Q  +    + + E + +  + L    L++TK   ALQ QI + +V  +KL     ++   
Sbjct: 1975 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 2030

Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
               +LP+    ++T   + V   + L +   +   KLQ  L +     +    +   +  
Sbjct: 2031 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2089

Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
            + S+L     V      L + IS    ++++I G+ + +     + K+ + +    +   
Sbjct: 2090 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 2149

Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
            L+ ++  L  ++   + K    L +++ L   +  +   S++L  +LE+    L      
Sbjct: 2150 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2209

Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
              +V++    ++ + + F E  K ++   SL   + S      H   +D A +       
Sbjct: 2210 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 2263

Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
             +K+  +   + + +E +   Q +    +  +  + SW+     +T+ +  +  PS  A 
Sbjct: 2264 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 2319

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
             +   L+  K+ + +   K   +  VN S + L                     +  + E
Sbjct: 2320 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2379

Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
                   EF  + G         +++  +  +  +L  KI  L   L  + +++ +   +
Sbjct: 2380 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2439

Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
              WL+   +     Q+   P    +V+  +   +  E +L      + ELK     L   
Sbjct: 2440 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2499

Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
              ++   P  +   + ID  +Q+       R   L + +   T  Q+V   L++W +  +
Sbjct: 2500 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2559

Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
            L   V               P+ +    L  Q + +Q L  E  + +  +E+L    Q +
Sbjct: 2560 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2606

Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
            + +  G  PS+  I++E+     ++W  +   ++D+       +     Y +     + +
Sbjct: 2607 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665

Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
            L   + K      +S   + + + L  A +  +E+Q + ++ K  +A  ++ S L +  +
Sbjct: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2724

Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
              ++     L G L S     Q+A  +++ +    A+  +F     +DF   L++ K   
Sbjct: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2780

Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
              EE+N        LD L    K++ D        LTAQS   E        + LK   S
Sbjct: 2781 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2834

Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
            + A   LQ   +   W        ER ++L+     EK L   E+      WI   +   
Sbjct: 2835 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2892

Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
            E +K      +  NS+ +L   QK        V +    A+S       LL   EI+   
Sbjct: 2893 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2943

Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
            E +T+ +K L  +     + +  +K  ++ + +++++F    +   R L      L    
Sbjct: 2944 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3003

Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
            ++  Q   + Y T   + + + K +   + +   A  L A + ++  +D K    V  ++
Sbjct: 3004 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 3059

Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
              +      +  Q+ E     ++ ++     +  I+E+ S+      +  S  P+    E
Sbjct: 3060 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3119

Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
             L  +KE IK   + L A    N    +T K  L       D++ +K  +E L +Q   L
Sbjct: 3120 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 3179

Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
              R   R++++E  +     F  K KE    L + E        + +E         M +
Sbjct: 3180 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 3239

Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
              QK   EEI      +  +  +G  LI+++ KS + + ++  L+ +N RW+ L   +  
Sbjct: 3240 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 3296

Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
            R  +L+E      +    + +L +W+   E EL         + + ++ ++ EQ+ LQR 
Sbjct: 3297 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355

Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
            ++   + VE       V+  + +  A   E  D ++  +    LD RW  +   +  R  
Sbjct: 3356 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3408

Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
            ++E    + Q+F +      +WL + E+            +  +E++ + +A +  I   
Sbjct: 3409 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3468

Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
            ++ L Q   I +  + L+ RE++    S+L     + +Q W   +Q +  +    L+   
Sbjct: 3469 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3523

Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
               + F      ++ WL E+  +L+  +V+ +S      +  +L   Q++I L    +DQ
Sbjct: 3524 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3583

Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
             ++ G +L++++   + ++I+D+LE +    +++            +  +  RRL S   
Sbjct: 3584 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3643

Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
              CT   + E E    ET +            P+E++ ++   +   +  +   S    +
Sbjct: 3644 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3703

Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVP 6457
             P   R G E  V+ D+   E         +   EE +     S    ++     SW   
Sbjct: 3704 VPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3760

Query: 6458 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6517
                       ++E D+    +    +   +    K ++    D  K G +++    ++E
Sbjct: 3761 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII---DDLVKSGHKIMTACSEEE 3817

Query: 6518 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6577
               +    ++    +D    I ++      + +  + Q       +  WL +T++ +  L
Sbjct: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3877

Query: 6578 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
                P  + + +  + +  +++ +    +K  +  +N +  + L+    E   +Q +   
Sbjct: 3878 --PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3935

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADP 6696
               L+   +  V      L +++ Q   FH     +L  L     R RQ   ++   A+ 
Sbjct: 3936 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS---AEV 3992

Query: 6697 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              + E   E   +  ++ + QP  + L++    ++ +  G D    +     ++ KL Q+
Sbjct: 3993 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD---KDISAKAVQDKLDQM 4049



 Score =  174 bits (440), Expect = 4e-42
 Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)

Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
            LQ Q E  K F +KL A ++     + K    +L   ET   + V   + LE  S+QC  
Sbjct: 3121 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 3177

Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
                LL + +  +E      K LE   S L   S+       L+++   +++ +  +G +
Sbjct: 3178 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 3227

Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
               + Q LN             +GKQ                S S   LE  +  +  +W
Sbjct: 3228 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3287

Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
             +LNKK+     +LQ  L H   +    + L  W+  ++  +   K  S     +   ++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3343

Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
            + I       + +D++ S    +   G ++    E  D   +   L+  + +W  L+ + 
Sbjct: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403

Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
                 +L  + +      + +  +  W+  +E +  + + + +   AS+++  + +HK  
Sbjct: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3461

Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
              ++ ++ + +   V+  QSL  LS+ + +     + +F++        W+  +    + 
Sbjct: 3462 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3514

Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
            + + L+Q L  +    E++++++N WL    ++L  L            Q+ E  +  + 
Sbjct: 3515 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3573

Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
            +LL  Q+++  L      L+ LKQ+        V +++D    I   ++  + + T V +
Sbjct: 3574 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626

Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
             L+ ++Q   +    +++L   ++ + +     + +   V+   E  + Q+   + L+ E
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3682

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
            A++++   + L EV   L  L P  A E +E+     ++R+  V+  I  ++++  + + 
Sbjct: 3683 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3742

Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
              + +  A     + + + E K   L +I +             QD    Q  VQKT   
Sbjct: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3790

Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
              L++  ++D L +    S H ++     S +    ++K L      ++ +     +  +
Sbjct: 3791 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3844

Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
            +LE  + L+    E  + L     E   S ++ + A   +   +    E   +L      
Sbjct: 3845 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3903

Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
             K  +  MN+     T   L   S  +G  + EK++     + Q+ E +       +EA+
Sbjct: 3904 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3958

Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
                    K+D +  SL  ++E+ +    + AEV  I + I++    S   + LQ L  T
Sbjct: 3959 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 4018

Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
             ++ R E +   S  TD+  +A    +  +  +D +V  W++  T VE            
Sbjct: 4019 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4073

Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
              +F  D   L+  +K  + F           S+ + +    E   +EI   +      +
Sbjct: 4074 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4133

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
             L  G +L+       K  V + I +L  +W  +     + I + +  ++   Q +  ++
Sbjct: 4134 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191

Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
             +   + +   +     P +  DL   K+ I+EL+Q  +   Q   E++ +  +A+L   
Sbjct: 4192 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 4250

Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
             + E  D   +++ +  L   W+ L  R+  R+ ++E  L     F     EL AWL   
Sbjct: 4251 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4310

Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
            E  + +   +  +     IE  +   ++   L  ++ ++ + + G+ LI++S    A+ +
Sbjct: 4311 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4370

Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
             +KL  +N RWQ++ +    R ++L       +     + +L+ WL   E  L  SKP+ 
Sbjct: 4371 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4429

Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
                    + +   EQ ++  ++     A  E+  ++          C    E + I Q 
Sbjct: 4430 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4482

Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
              +L  +W ++     ER+ K+EE   L  +F +    F +WL  AE+T    +   ++ 
Sbjct: 4483 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4542

Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
             +   ++   + F  +++    Q+  ++K    L   ++      +K ++     RW+ +
Sbjct: 4543 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4602

Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
             +R+    R L     + ++F      ++ WL E +  L + +E  ++ D    ++ Q  
Sbjct: 4603 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4662

Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
             FQ+ +    +  D     G  L +K+   D  L ++D L EL      + G+
Sbjct: 4663 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4715



 Score =  160 bits (404), Expect = 5e-38
 Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)

Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
            LT  S    LS G T+ L   +  A T     G+  +    + P+ SL+   KL +I++ 
Sbjct: 530  LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 587

Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
            +L  K S++   L E +I       L   + E++ Q +     SDL + + S L++H   
Sbjct: 588  LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 641

Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
                  KN +      + +LKE  + SE + +   KL        LE + +K+       
Sbjct: 642  ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 691

Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
            ++ ++HL   H    +S    +   L + E   +  A +  +    + R +D H  L + 
Sbjct: 692  RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 747

Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
            L  +EE  K ++E  E+         L  +A  A  + Q+  + QL   ++++      +
Sbjct: 748  LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 807

Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
             E      EAT  +   +  +++    +    +   ED  Q   +   +++ +   I   
Sbjct: 808  FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 867

Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
                ++++ L       PL               E  I K  E +L      A+ + I  
Sbjct: 868  MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 927

Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
                +  P V        K   D++N    Q+ N L L   + SH     +    YL ++
Sbjct: 928  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 985

Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
             D +R   +   K    G   +H       Q + ++ FL+ +Q        D+T L KE+
Sbjct: 986  IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 1041

Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
                 Y  E  K+    E+                L +++  + L++Q++  ++  D H 
Sbjct: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101

Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
                + E +  +  +  L     T+ N  +EF S +        +  +L  + +  N++ 
Sbjct: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161

Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
                T    L     V +NT +    +   + K  +      E  + + K  +E  + S 
Sbjct: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 1214

Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
            LK  RS   EK+  F     E Q    + +   ++     L+ DW   K D  VE   + 
Sbjct: 1215 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 1274

Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
             + ++ +        +S+K   D    +++   Q       ++  Q E  + L TQL  +
Sbjct: 1275 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1334

Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
            K  +  +E       EC    E  +       L  + Y A  +D+  ++ +  ++ + S 
Sbjct: 1335 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1393

Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
              ++++F +              Y+     S+K L  +++SL+    + V    +++K++
Sbjct: 1394 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1453

Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
            ++I K         K      KI  E +S     + + L   Q+   +HG +  +++ + 
Sbjct: 1454 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1512

Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
            +  +QV    E     F+  + ++Q+++ S  ++ +++ +  R +  +E+      +   
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572

Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
            T+ +   H  + + G   +++K+   ++E+                KN E   N LK+  
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1629

Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
            E L                   E L+L+AE   K+ D  +   +KE    + A   L E 
Sbjct: 1630 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1689

Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
               I  L D   ++     +    H  ++ +            ++ EE +     L T  
Sbjct: 1690 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1749

Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
               +  T E+L  QYQ +             V+ +TQ +Q L   LE++  + +   K +
Sbjct: 1750 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1806

Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
            L     E  +      A +E ++K  H    + Q+EL++ D+  +     L    +EL  
Sbjct: 1807 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1862

Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
             E     D +  L  +  R + F ++    + HK    R      + + E A S  + + 
Sbjct: 1863 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1916

Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
              +     ++ V+ ++ +  DR  ++  KC +L    LK + D      D S   L  LQ
Sbjct: 1917 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 1975

Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
                   K L E I    K L    EE    Q  +S  +    ++KK  EV+L A  S  
Sbjct: 1976 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 2033

Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
                    +L  + +  K L D+I+ +  +     +   EK  + +  +    D L ++L
Sbjct: 2034 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084

Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
              M  +E S KE     L+    QD +  ++ +   I  +      +N ++K      D 
Sbjct: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144

Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
              A   Q   +  S +   A  K +E   ++  +++TK+  FE+L  +L T ++ +T  L
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 2203

Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
             +          L++Y +E+ +  +E    LE +  ++      G P +   + L K   
Sbjct: 2204 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 2262

Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
            L      ++D + EK   ++S + +L         L+  ++E   K   ++ +F A++  
Sbjct: 2263 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2322

Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
              + LE+ K   K++E       +++ V    +S     S   +  +A+  ++   A+++
Sbjct: 2323 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377

Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
                +T  E     + L  ++   T      E+ G+ L   ++ L  K   L +A +E  
Sbjct: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2437

Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
                W +++ +   +W+      + EA+     Q +  E    +     +EL + L  L 
Sbjct: 2438 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2497

Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
            +   +                K Q L  L + R + ++    +    +TV A  ++    
Sbjct: 2498 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2557

Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
            KE    +L  +  +  ++ T+ Q+     +E    K  ++Q T + Q +  +   + S +
Sbjct: 2558 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2617

Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
                E+L ++ +K       + +  R  + +   +   + +S +      L D+D K+S+
Sbjct: 2618 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2675

Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
             +  S+   AM +++E        +++ +QQ+ K I+ AQ + + +   +   + K  EL
Sbjct: 2676 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2730

Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
              +++ I      VEQ      + + +      Q+QQ+S+  +     +  + NK+   +
Sbjct: 2731 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2790

Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
             K++    L+K                E  I    +LL      +       L T+  + 
Sbjct: 2791 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2850

Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
             T               ++ AL+  EQ   L   +     +LE++    +  E   SI +
Sbjct: 2851 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2910

Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
            L +    + Q   ++E L         V  I+ EV     KS+ ++V  +   L SK+  
Sbjct: 2911 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 2970

Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
             +   ++  +  EV  E+ R ++          ++         L + QT  K L   + 
Sbjct: 2971 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3030

Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  +L QD+ +              +E + QE + L + V ++ +  + +++ +   
Sbjct: 3031 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 3090

Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
             N     FS      D+ D +  +  + E ++KQ   I +  ++ E L+           
Sbjct: 3091 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3150

Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
              L  E+      G++RD L A++ +   + +R A  R+    G++  L     +++E S
Sbjct: 3151 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 3208

Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
            +      +KAE   +S   +      ME +       TI Q+          +M ++   
Sbjct: 3209 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 3243

Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
            + +   QG +  +         +  +  +T  +E D  D +     L  +V +   +  E
Sbjct: 3244 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303

Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
             L  C              V   EL   Q   + E + + A +Q Q L Q+L+  +    
Sbjct: 3304 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3363

Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
            E+      K+A   E   K + L          EAL  K +T    LE + ++ Q+ H  
Sbjct: 3364 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3421

Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
                            E L+P+N  L+ +E  +        Q    ++Q+ + K +E  D
Sbjct: 3422 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3464

Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
             I             + +H +       +    SS E+ D+  S L       D  Q  +
Sbjct: 3465 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3505

Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
             E+  K       L +   +  +     V + N+              L ++  + S L 
Sbjct: 3506 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3551

Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
             Q+  TE     L K+  EL +     L    +V++ L       +  +G +V      L
Sbjct: 3552 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3607

Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
            E +K  Y  ++    D+ K +    +    L    + L   L+  +   +     +  G 
Sbjct: 3608 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3667

Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
            + +++ Q   K L  +  K+  +L  SLNE+S   +     +A       E  E  VA  
Sbjct: 3668 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3717

Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
             ++ ER  L    + Q+V +++  +       +A   ELS  ++TE+++  +  G + L 
Sbjct: 3718 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3774

Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
            +            QT +++ +Q     +I  HK     LV +   ++ A S +   S+ +
Sbjct: 3775 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3823

Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
              +       T  +I  E+  Q       + Q WE ++E +  L  + + +IS LP+ +L
Sbjct: 3824 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3882

Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
              ET  +  E    ++Q++  I      + +    G QL+      EL  G+   ++E++
Sbjct: 3883 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3933

Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
            ++   L  +I  ++ +    L   +S +    D++ + LES +  +   + Q  ++S ++
Sbjct: 3934 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 3992

Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
            + I+  I+     S ++++   L   +   G +++         + A   Q +      +
Sbjct: 3993 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 4046

Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
             Q+  I E +H L  E+      + E+    W +++    + +D+      +  P    S
Sbjct: 4047 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4106

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
             VK   +  +  R E+D  Q  +D V N     ++ C    K   +    + + E+N  W
Sbjct: 4107 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 4162

Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              ++     +I  LE+ +++  + ++ +Q + +W++    +L ++    + +   K    
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 4218

Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
             Q IE     KS+A  + +     L   A  LL+      D         EL     S+ 
Sbjct: 4219 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 4276

Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
             ++   +  ++  L     +    DE+          +   KPV    + +  ++     
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4336

Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
            LQ++  + + + E + +    L +      A  ++ K +  ++RW  V +    + Q+  
Sbjct: 4337 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4396

Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
              L+  K +   HGE    L+Q   + +   LA+  + G      E L   ++     + 
Sbjct: 4397 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4452

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
              +  K    +   +L R P+ AE++    +   +++L            +R   LE+ L
Sbjct: 4453 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4508

Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
             + A EF   L  F ++  + E    +       LD +  Q  E+   F N V +   Q 
Sbjct: 4509 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4566

Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
             +++    HL   S K  +  V +K L  ++  +W +     +ER   L       K  +
Sbjct: 4567 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4624

Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
              E W +L+E +EE+ K     +++AN   ++  Q   +K  +  +    ++ D+     
Sbjct: 4625 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682

Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
              L + T + ++  +     S+L D+W        +R+  ++  +     FT +++ L  
Sbjct: 4683 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4742

Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
            +L      L+     E   ++    L+  L +    FQ+   +RT+    L+   + L+ 
Sbjct: 4743 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4797

Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
                    V  ++ +L   W+ +       + +L   ++Q   F S V    +   +  E
Sbjct: 4798 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4856

Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
               R   +    ED L  L   +   KE +K+LE+  A     L +  TM   +      
Sbjct: 4857 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4909

Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
            + +  +K  I  +  ++E++       +Q +   L   +   E  + L AWL   E  + 
Sbjct: 4910 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 4969

Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
                  I + IE++ K  + E   F E ++  KQ     +  + K RAA+
Sbjct: 4970 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 5017



 Score =  155 bits (393), Expect = 1e-36
 Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)

Query: 616  ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
            ++L +   E  +L E     VE + ++    S+ISK L+   K  +   SK ++      
Sbjct: 1423 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1482

Query: 669  ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
                        + L + K      D   N L K+ K   E     FS  +        +
Sbjct: 1483 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1542

Query: 714  QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
             ++K  EK   E + E+  +L+   D+      +LIG  E +       ++     +  E
Sbjct: 1543 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1601

Query: 768  ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
            E  K +        E++  +E+ L+ + + +S ++         ++ K+ EAK K +   
Sbjct: 1602 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1655

Query: 828  VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
            +K   + K L  V        +  +    ++EES+ ++E+ +     +    E  G   +
Sbjct: 1656 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1712

Query: 880  KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
            KHK+ +  + T       K+     +E+  N+ E D+   +     ++  +++ +  +  
Sbjct: 1713 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1772

Query: 935  LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
              + Q +  I   + +  +L+ + Q ++ E+K   +   K L   +E   +E     +L 
Sbjct: 1773 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1832

Query: 994  HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
            H ++      EEL        E +  L+  EQ++E L   A +I+  +       S +E 
Sbjct: 1833 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1886

Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
             I         T S NR  +       +K D       A    ++  L       +    
Sbjct: 1887 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1944

Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
                   ++  L+++Y  Y D    L   LQ  +   +   S         LQ +L + +
Sbjct: 1945 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2004

Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
             ++ +  ++    E +    E  +          NDI+K       D +  R  +L  ++
Sbjct: 2005 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 2059

Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
            N R E L+  L   L V+              S L     +PL+  A+Q       D I 
Sbjct: 2060 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 2112

Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
            +++   QD   +Q  I N + E     ++   P    ++Q  +     +F   +H+    
Sbjct: 2113 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2171

Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
                      V+  E+  + L+ FL +    L    +  + VT+LS    +   E     
Sbjct: 2172 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2231

Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
            K+ E    L+K+ + H    DK L +     L   FK+ E      +   TSC+  LDAF
Sbjct: 2232 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2291

Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
             + +     +   +E T++  +++   F   +L K+++D +    K  LK P +  V + 
Sbjct: 2292 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2348

Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
              SL  L   +    +    ++             N+   + +    ++ +   +    +
Sbjct: 2349 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2408

Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
            E+   L+ + + +    L  L++ Q   S +   +QK     +         + +    +
Sbjct: 2409 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2468

Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
            +E  K    E  + V+K+ ++   L   L +     E P  K+    +D +W ++N+ T 
Sbjct: 2469 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528

Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
            D  + L  +     +   ++  + +W  EK L    L  L+  D   L  + Q  +    
Sbjct: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2587

Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
            EF+ R  + + L  + +  L     + S+   ++     +T + +  +L+G  ++  + +
Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2645

Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
            DQA  +    +SLL++LS          S SL + T                +EIQQ+  
Sbjct: 2646 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2705

Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
            Q K +  L E+    +  E   +EL +Q E +   F   +   ++H   L          
Sbjct: 2706 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2765

Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
                ++F  W    K    +    S     +E  ++   DF  TL  ++   ++  +  +
Sbjct: 2766 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825

Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
            ++      +    L   L   +   +      + R  +L++SL++ L+ ++    L  W+
Sbjct: 2826 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2885

Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
                N  E+ K   +P  GE +    ++L ++ +Q F  V  LNN+           KE 
Sbjct: 2886 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2945

Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
               E + +I +   + ++  +            ++  E+ +E K                
Sbjct: 2946 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3005

Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
                       +L T+ +S   L H V    K + + L+V          E    K    
Sbjct: 3006 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 3054

Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
            +LL+ E  A+  + + Q    +   ++  L  I +  +    + S +    ++L      
Sbjct: 3055 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 3114

Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
              + E   + KE ++  L +L+       AL           K+     + + DL  + +
Sbjct: 3115 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 3167

Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
            +L++   Q N LL+  +  +  E+    IK L E  S L++    +Q  +    EH+  Q
Sbjct: 3168 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 3221

Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
              V     T++     F  F  + +      E LQ  Q+  N L            L +S
Sbjct: 3222 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 3266

Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
              ++TS+ G +   DD+ +  +   K +  R A  ++ +  C      L S+L     TE
Sbjct: 3267 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3326

Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
            +     L   +K  +++   V+   QE   +++L +D     E+ K    ++A + +   
Sbjct: 3327 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381

Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
             + +  Q S+ ++  E  +N  E +N+ LE  +++           NE L  IEK     
Sbjct: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441

Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
            E        LE+    +K     ++ HN        IG S + L +     +   K   S
Sbjct: 3442 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3501

Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
            Q   + + QE   +    ++  L + +      ++ + +L+++   ++ +  +  S   L
Sbjct: 3502 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3560

Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
               W+  S   V   D  L +  + Q L +G E ++Q        IQ K       Y + 
Sbjct: 3561 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3617

Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
            T L   V  T     +Q   L  RL S  E            +++   +   VLKG    
Sbjct: 3618 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3670

Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
            QA+++ K +  E K  K L D +N +         W   E L  + AE+    ++    I
Sbjct: 3671 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3730

Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
              K++E                  + W      +L     I L  D   +Q++  K    
Sbjct: 3731 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3790

Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
             IL  +  ++ L +     + + +  E   +   L+ +   Y  +   +++R  QLE   
Sbjct: 3791 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3850

Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
               + F+    +    + E+++ II ++   A E E      TL   Q+E +++   I+ 
Sbjct: 3851 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3903

Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
            H   +  + +      EL+  E   ++++        ++I+  ++     ++  I    Q
Sbjct: 3904 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 3963

Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
            FH+K   + E   S++R    L Q  +  +  E+  +K++++  K   + + KL+ +++ 
Sbjct: 3964 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 4018

Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
            +            G + D S      +LDQ+        T V E+E +L + ++  + F 
Sbjct: 4019 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 4078

Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
             +H      +   +    DL+   +   V+K    + E+ R     L + ++    L  E
Sbjct: 4079 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 4138

Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
            +I    E    D    +K I ++       D L K  ++ + +L          QD L+ 
Sbjct: 4139 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4192

Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
                ++    +L     I  +++ ++ + +       EA+Q+Q+  E  + +A   ++K 
Sbjct: 4193 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4252

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
             EE  S+   V+  L E + +   L   I  R + L  A   L +++ A+   +  +T  
Sbjct: 4253 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 4310

Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
            E ++   +  VG   +++E+ L K   L++ V   Q   E +          S+ E    
Sbjct: 4311 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4369

Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
            LQ  L+ L  +   + E  + ++ + +  L   K +    ED+   L+  E  L   + +
Sbjct: 4370 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4429

Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
              LP + +E L   +E   A  +   + K  + K +Q+L     RC ++    + + ++ 
Sbjct: 4430 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4485

Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
            L EKW S+     E +   EE                 W   +E+      R ++ILD +
Sbjct: 4486 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4545

Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
              ++ E  +   +  +  E++ EL      L    Q  + V  + LL+++  +  + +Q 
Sbjct: 4546 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4605

Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
            + E   +++           A+ ++    E   K L    ++  + + ++T++ +   F 
Sbjct: 4606 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4665

Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
            K + A  + +  T  + +++  +     D+ +  +   EL              Q+ L++
Sbjct: 4666 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4725

Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
              L      + L+     +Y + P   E Q      +    L D  +    E+ K + S 
Sbjct: 4726 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4785

Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
             A++R   E+  G  +    V+  +Q+ S   E    +       L+    +  E  S V
Sbjct: 4786 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4845

Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
              ++E         +  G   +  D L     Q+++  ++ E + ++LNKAT   +    
Sbjct: 4846 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4905

Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
              + D + + + WI      +      + L     H   +  AL     K  LL ++   
Sbjct: 4906 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 4960

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
            L+       TD+  + I +   +V AL    Q  ME + + Q   D V
Sbjct: 4961 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007



 Score =  155 bits (392), Expect = 1e-36
 Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)

Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
            +L  L+S+  ++L +  ++  FS     +++       Q  Q+ +++ +   +E   Y +
Sbjct: 1008 VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 1067

Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
             ++++     N      +  D+ + QI    +   L E   R++ Q+   K++  L    
Sbjct: 1068 YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 1119

Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
                        KDD+ ++  +C++   +   +S+   +   LN +L++           
Sbjct: 1120 ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1167

Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
            +   + +  + V ++TQ + A+ KL E     +++ +    + +  ++  +  ++  DE+
Sbjct: 1168 ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1225

Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
            +       +ELQ      D M +  +  +++  +     K+ A + +E+ + ++      
Sbjct: 1226 RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 1276

Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
                        +DN L+ L  + K+ +          +++  VE++ + +   +E+   
Sbjct: 1277 -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 1322

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
                  T L++ K  ++ IE ++  +   +   E  S  V D +      + +++SQ K 
Sbjct: 1323 NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1382

Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
                   +     I +++      Y    TLM +      D+   L+++++ L+   K  
Sbjct: 1383 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1442

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
             E+A          +LQ      S     AE   K  +  K+K + E+     ++  E L
Sbjct: 1443 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1492

Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
            + + L       K   + RN++++ +         L  S  LL  + L Q+++ + + D 
Sbjct: 1493 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1544

Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
            +   ++ V    +E K+K+      LT  E   + +    +     + + K   + ++L+
Sbjct: 1545 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1604

Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
              ++  +   A + K          + + QE + LI    E    EA++K   + L+A Q
Sbjct: 1605 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1660

Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
             + +E+D  ++T ++E T         E++    QL+  K +   +  ++ N   + E  
Sbjct: 1661 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1710

Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
                +Q  E+     +E D           N  LL  +V+  V     NL  +   +K  
Sbjct: 1711 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1770

Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
              +++   +       +       Q Q    E++++L++ +K+L    E      AL   
Sbjct: 1771 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1825

Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
             + + L      E+     D +     L  Q   Q +E  +   D+I   + KL   K+F
Sbjct: 1826 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1883

Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
             +           + + + D  Y  +  N VLE +         ++D      +++  L 
Sbjct: 1884 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933

Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
            H  ++ +S   +  ++   +K + ++  + E     + A + + +A TA +   E  + +
Sbjct: 1934 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 1992

Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
              +++ +L E + LQ Q+++       +     VL DA  +L   K  + + ++ I    
Sbjct: 1993 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 2048

Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
                     VG  E+  +    + E+L+ T+     +QD L E L  + + E+ L+ Q  
Sbjct: 2049 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099

Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
                   LQ+++SKN  +++    +++      E  K + +  +    ++L      L  
Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159

Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
              S     ++E L ++E+ K  V    +  E   KL+  L       TE D  G  + ++
Sbjct: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 2216

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
               + E     LE  K  E+    LK+     S  +  + A++L+   NL ++  E+  T
Sbjct: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2273

Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
                KEA T+          CQ  E ++  Q+L+  L   I+            + VP  
Sbjct: 2274 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 2312

Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
            Q     ++   K L+  +K +E    +  E        I+L N     TT  + +A    
Sbjct: 2313 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2371

Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
                   +     +E+F        KG  + +  M  +   Y ++  ++    AE+ +++
Sbjct: 2372 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2426

Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
             + +KA E+        +K++    K   + A     E +   +   +    +  +N+ K
Sbjct: 2427 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2485

Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
             QE++ K+ + L+          W   L E+DS+ Q++ +   D  Q  E   N +  FQ
Sbjct: 2486 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2545

Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
                Q +Q     E   S              Q  +  + ++E++      E        
Sbjct: 2546 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605

Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
            +L+ P +  SLR                    LS     +  A+  S Q  +LL S+   
Sbjct: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
            L DL     +     +  +  NQ     QK+ + + Q        Q + +D+ A+  E  
Sbjct: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725

Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
               +   +++ IL S +  +   E H++H +    +    ++   +  ++    +  Q  
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2785

Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
              P+            + +LE++ ++  +  K +  Q++ +++ I   + +L        
Sbjct: 2786 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2828

Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
            L+    ++A    +L  ++   +   KQ+    N+ KE L   +  K  V  L   + + 
Sbjct: 2829 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2888

Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
            Q  +E  +     +E E  +A+  + ++++           N   S+  +  +++EV   
Sbjct: 2889 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2948

Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
              KS     D   E+         ++ +  K+ +E   S  S   +Q A  ++   D+  
Sbjct: 2949 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 3006

Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
            +Q  +   L   Q  + SL+  + +      +  D  +++SD++G  +   +VE    E 
Sbjct: 3007 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3066

Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
            + +      + + LE  LQ      N   E  +  A+               + L++Q  
Sbjct: 3067 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3126

Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
              +A L ++E  +A      +TCK     ++   D    + + EALS +    L   +  
Sbjct: 3127 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3186

Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
             E+V+     L+E +S+ +  +IL + +E EH+E+  PV + E E+I     Q +  K F
Sbjct: 3187 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 3241

Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
            Q++++  L+  +Q  +++    I+  AK    Q  +HD D       T  +  A   A  
Sbjct: 3242 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 3301

Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
             E         D  +S+LS        W     EL +  K P                L 
Sbjct: 3302 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3353

Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
            +L++ + ST                    + IL  +++ + R+     + +T   QLE +
Sbjct: 3354 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3413

Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
               A           E    ++K+L       +Q  S +EE +   +   +D      H 
Sbjct: 3414 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3471

Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
                     L+ A+S   G  LK ++   E+ +++    D  QV     Q  +  RS+ L
Sbjct: 3472 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3519

Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
            +  L   + +  +   L + L +    L + S+ + S + + +Q  +      ++   + 
Sbjct: 3520 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3579

Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
             V +    G  L L      EV  ++D L++    ++ARY +++  S  V ++ + AL  
Sbjct: 3580 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3634

Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
               L    E     L K+  E L++   +  K + A QAQ+         +N+K     L
Sbjct: 3635 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693

Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
              V+  LL      +++P         W  +    K++ E + +  +   ++ QK EE D
Sbjct: 3694 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738

Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
               A++ +  +   +    +S + ETE++L+         ++ S   Q+++    +  R 
Sbjct: 3739 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3795

Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
               +++    G +++ + S  E +    KL+      +    +N +   +L R Q+L+  
Sbjct: 3796 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3855

Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
               +    ++L  WL  +Q  ++     +L    + +T+R       +  + + E     
Sbjct: 3856 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3908

Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
              +   G QLL L   +  +++      +  ++ +   +      L +   +       I
Sbjct: 3909 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 3968

Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
             +++  +  +  +     S+ +     ++K  + ++K   ++M+  Q + + + Q   ++
Sbjct: 3969 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026

Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
                  +  D+ +K  +     + L +M   W  +H ++  +   L  ++E   +     
Sbjct: 4027 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4081

Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
              L   ++  ++ ++ L+ P    SV K     Q+    +  +   L E     + L S 
Sbjct: 4082 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 4138

Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
             +    +         IDEL     S+      ++++L+ +MQ+ +Q       ++D V+
Sbjct: 4139 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 4198

Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
            +   +    +    P+   LET++ Q+E L+  + EA   +   E+L      L  K   
Sbjct: 4199 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4254

Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
             S    +++        W  + + I ++  K +  L     + +A  E  A L   E   
Sbjct: 4255 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4314

Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
             +   +   G+  A  +  A   +  LQ+DV   Q T EA  +  + L       E+S  
Sbjct: 4315 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4369

Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
              L   L  L QR   + +    +  + +  L Q K F   +E L+  +   E +L    
Sbjct: 4370 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4427

Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
                L +  KE  +  +    A  A+    + L     ++  + P S      + + N+ 
Sbjct: 4428 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4487

Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
             +W        ER ++L+  + L  +F    + +I  L + E+ L V    S P L+   
Sbjct: 4488 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4544

Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
              +++ E +V  N+   +S+  Q ++L  T T ++  ++ + +     L      RW+  
Sbjct: 4545 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4602

Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
            VQ + +R   +D   ++ + F  +   L  +L ++   L S ++        +T+   H+
Sbjct: 4603 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4662

Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
               K +    + +    T   G  L   T L      +   +S+L+D W  +  +  E  
Sbjct: 4663 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720

Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
             + +  +    Q    ++ L   L  ++ Q  +  P +H D+     LI   K  ++ L 
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4779

Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
              T +++ L+    +L      +D   +K Q++ L  +WE +C     ++  +E  L   
Sbjct: 4780 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4838

Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
              F+     L  WL + E       VL   + ++  +I++  K+ M+++        +  
Sbjct: 4839 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4897

Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
             MGD ++   +      I   +  I  R++ +        ++L    A +    + +  L
Sbjct: 4898 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4957

Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
              WL   E+ L+   K V+    + +E++  +AE Q    ++ +    V+ V        
Sbjct: 4958 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 5015

Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
             D  +                           ++T+ ++       L  +W+ +  +++E
Sbjct: 5016 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 5075

Query: 6127 RRMKIEE 6133
            RR K+ +
Sbjct: 5076 RRRKLND 5082



 Score =  146 bits (369), Expect = 6e-34
 Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)

Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
            P+  +AM P++ F++     P  +E++     +E+ Y   +    E +   + ++  H+L
Sbjct: 927  PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 982

Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
             N   RI  S+ +S +       Q  L++LQ    +     +E ++ S     +LE  VN
Sbjct: 983  INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 1042

Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
              K+ +    ++ LK  ERE Q              +  R+E+ E  L  ++  P+E+  
Sbjct: 1043 VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1098

Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
            L         H+     F + + +++ + L  ++D +     I N+ EE  +        
Sbjct: 1099 L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 1143

Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
              L +  N++L+   Q   M+       D LK +   L + + A+   +   T L   + 
Sbjct: 1144 PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200

Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
             +A +N +     T+K    E+       H ++D   KAK +     K  K  D+ F   
Sbjct: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260

Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
            +   D   E   N+      +L +  G G   ++  +    L+  I +     + IQ+ Q
Sbjct: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320

Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
             + SK      T+    +++K L+  ++    + +E +++ ++ + ++   KD   +T+ 
Sbjct: 1321 PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1371

Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
             +     ++    K+ V     Q    L +++++ + ++  T L+      +  Q     
Sbjct: 1372 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1421

Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
             ++LK+   E + ++EE  EH+E   ++ +   N+   L   +   +PPF K+       
Sbjct: 1422 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1475

Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
                +E+     E L  AL            I  +  K   KM     T+E+R  L++++
Sbjct: 1476 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1518

Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
            + + E     FS  + ++Q    S ++ +E +++             I + +   +  L 
Sbjct: 1519 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1578

Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
            G      +   T EL+    +  +  K   G  ++L + +  +++   E   KL +  + 
Sbjct: 1579 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1638

Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
            +++QK    L E +I C  L  +  + KK+ + V      +++       +L   + K  
Sbjct: 1639 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1694

Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
            N  DW SN+  + +                F+  + K ++ ++ +   + L         
Sbjct: 1695 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1754

Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
             T E  N + ++V    + ++   +  +      +++    GQ    E+ E + Q   KE
Sbjct: 1755 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1813

Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
            L+                  SLQ+ L   D D+     WL   E++ + +E   +     
Sbjct: 1814 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1873

Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
               L R++   E V      L+    +    +    +C                      
Sbjct: 1874 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933

Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
               DR+++L  + + +    K L  + Q + D                       +A D 
Sbjct: 1934 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 1993

Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
             +  ++++E+  +      +    E+++K  E++L     DAR   +  + +      +Q
Sbjct: 1994 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 2042

Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
            KTL DI  ++++   L+ +     EKL +   + L  ++ L  ML     +E   K++  
Sbjct: 2043 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099

Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
              L        A   I  K +   QD+       +S  N + E  K    + +P      
Sbjct: 2100 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 2145

Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
               SL  +++D          +H      + +L T +   +N S++  +F +     +  
Sbjct: 2146 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2205

Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
                   V E  Q +QE  +        L+ + +L K +  +     + ++ +   +L  
Sbjct: 2206 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 2265

Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
            K K++E+ +   K+ +  C         ++KS +S  K+    +P  +      D+ +S 
Sbjct: 2266 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 2325

Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
            +++   +KL+E W     EI K                    A+    S    LN + + 
Sbjct: 2326 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2382

Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
             NTE+          ++ + ++ +   +L  +L+++  E   KL    +A++ +   ++ 
Sbjct: 2383 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2442

Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
             + +NKT T         +         +A+ T +++NK               + E+ +
Sbjct: 2443 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2479

Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
            K  +   + LK    D +T L +         + K  L  +  KW+ L+    D  +KL 
Sbjct: 2480 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2535

Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
            ES     +       Q ++ +  Q +VE +   +++  +      L  Q+Q +Q+ L+  
Sbjct: 2536 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2589

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
              R             Q T  G  +L    E           +  +++ +  + ++W++L
Sbjct: 2590 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2634

Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
                 +  + I +  +++   +++L +      +L  +L+ S+ +   PD +  Q+   +
Sbjct: 2635 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2694

Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
                 I   ++ +   ++L E++   V     Y  ++L+  LE +   ++ +  K+    
Sbjct: 2695 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2752

Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
            Q L+        F  + R FQ  +   +            E + K H ++     LE+  
Sbjct: 2753 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2800

Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
            K+ ++    ++  +H+ E T     N+  +    E+  L+ QL  +K   +   + ++  
Sbjct: 2801 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2860

Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
             N+++  ++   ++ E+   L    D  Q N  E+    +  +G              ++
Sbjct: 2861 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2920

Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
             + + + L      +L V ++ K            ++D +  Q+  K+  LE   ++   
Sbjct: 2921 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 2980

Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
            F+E  +  K Q   +K   +D+     ++       +  ++++ + Q L  +++ AK L 
Sbjct: 2981 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3039

Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
             +++ + +++K   D      +LQ++  A+E+  L + +      L  K     + Q+ +
Sbjct: 3040 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3094

Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
                    +   +L     +  + + +Q +K+  +AF +++ A M S        K    
Sbjct: 3095 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3154

Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
                + D+    R+ E L  Q N  +D               L + Y  L  +   + +A
Sbjct: 3155 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3214

Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
             E   S      P  ++     + L M  + ++EE+E      QD+     G+I S    
Sbjct: 3215 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 3270

Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
               Q    +L   N+  K   K     A +  E      + ++ + + LS M    E V 
Sbjct: 3271 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3330

Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
             Q   S    ++    ++++ K L   L   K  +  +++    +       D + +LK 
Sbjct: 3331 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3388

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
            +S L  +W +LL  A+      E +    +   E +E     L  +++ L   E   T+ 
Sbjct: 3389 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3448

Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
            +   E++++   L D +  + +++ +      + + +   + +  E    V++   F ++
Sbjct: 3449 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3503

Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
              +     ++ +K     EL+Q  +     F ++ + L N+  +       ++ QD+  +
Sbjct: 3504 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3558

Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
               +Q  EL+ + +   L  +N+ + L      +      E   I+ ++E  +   +DI 
Sbjct: 3559 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3617

Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
             K+S +V K+   +  + R++    EE+   L  VE  L        K +   +AQ   K
Sbjct: 3618 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3677

Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
            ++  E     + L+ L+     ++E  P +A+E ++ ++    ++Y+ VS     +  ++
Sbjct: 3678 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3737

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            + A ++ +++     +  +WI  T   L +  D      L    ++ Q+ ++ +     L
Sbjct: 3738 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3793

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
             H   +           D+L +S  ++    +  + Q + + L ++ +  D +  I SE 
Sbjct: 3794 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3842

Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
                                    +   +  +S++    L  E      EEH +  E+I 
Sbjct: 3843 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3902

Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
            E   +I  M KT  +++        P  G      +   + L   IK  E+V +++   L
Sbjct: 3903 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3954

Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
               I Q+ ++ ++I+ + +         SLE +  ++  + P +  E+E++++QI     
Sbjct: 3955 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 4000

Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
              +++ VD++  +  L++ LKQ  E
Sbjct: 4001 ENKNVSVDME-KLQPLYETLKQRGE 4024



 Score = 88.6 bits (218), Expect = 2e-16
 Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)

Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
            ++LS   G+ +QE++   + L              L+  I ++ +    I  +   + +I
Sbjct: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978

Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
              +    P++ A        +   K   + ++K+   YE  K+  +EM A S    KD  
Sbjct: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038

Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
             K V  +    V +WEN   LV E   +   V+EL +++  +  S++ T+   ++ +  L
Sbjct: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4098

Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
            +   +    +K++    E ++EE +   E +D +  +   L   +      ++P  +K  
Sbjct: 4099 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 4155

Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
            + +   W  +N+  +D  + L  A+    +  +    + +W + A  K+        D E
Sbjct: 4156 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4215

Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
             +K++++  +Q  SE  ++  E++ L   +E+ L+    ES        L +++ +   L
Sbjct: 4216 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4275

Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
                 +  H L G   +  + +  LD+    +  TE LL    P        ++E  +  
Sbjct: 4276 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4335

Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
            +LQ              K    L+E+  G     L  +L  L +++++V +    +K  L
Sbjct: 4336 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395

Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
                  +K  + + ++   W ++ + +L   K      ET K  EQ    +      E +
Sbjct: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4453

Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
                K +    + +    PK+    +   +   + + E +E+    R  +LE++L   + 
Sbjct: 4454 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4513

Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
              +  ++   WLT  E+       P           ++ ++F   +   REQ   + +  
Sbjct: 4514 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4573

Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
              LK   F++++++++    L+    R++ ++++L E            + F++    ++
Sbjct: 4574 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4631

Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
             W++E ++SL      + ++ +     KIK  +    E    +    ++      +   L
Sbjct: 4632 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685

Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
             +KT            L+++ ++WD     +    +  E+ LL   ++  + + L   L 
Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4745

Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
             ++ +      +   +      +  +K F K+    TS ++ LK     L+E ++ + S+
Sbjct: 4746 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4805

Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
             +    E+    E++          L+  +R+ + +   V  L   L    +        
Sbjct: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865

Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
            P D+ A+   + + +E   +L  +   L K       +LA+       T      II+  
Sbjct: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925

Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
             + +    K  + RLAS      AKQE +E  L  +  ++ +   K K  +P   ++  +
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985

Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
             +       +E T++   V+K+ + ++
Sbjct: 4986 LIAEHQTFMEEMTRKQPDVDKVTKTYK 5012



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)

Query: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            D+W+ I  + +  + K+++ L    Q    + A+  WL + E +L   +      DI  +
Sbjct: 4707 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4764

Query: 6590 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6649
               +   +   K      + V ++  S++E ++    +S+ ++ ++++LS  WE      
Sbjct: 4765 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4824

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6708
             S +  L  +L Q ++FH +   LL WLA A+   R    + D +   R L++  +E M 
Sbjct: 4825 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4883

Query: 6709 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              K+L E++ +++    + +++L   H +     +  + +I  + +++
Sbjct: 4884 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4929



 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)

Query: 6548 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6604
            K+++ +Q   Q    + A+  W+     +L    M+   +D++ ++ +++ L++      
Sbjct: 4175 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 4232

Query: 6605 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6662
              +  +  +N  ++  L+  TE  +   +Q  L +L L+W++ +  + + +  L  +L+ 
Sbjct: 4233 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292

Query: 6663 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6720
               F      LL WL   +     QK    DPKA    L +       L+ +++  Q  V
Sbjct: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4348

Query: 6721 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6774
            + + +  N L+    GE+    + K+ V+ ++ + + E+  Q    L G    A
Sbjct: 4349 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4402



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 56/276 (20%), Positives = 107/276 (38%), Gaps = 24/276 (8%)

Query: 6504 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 6550
            K G  VLNG     N ++   + GL  I +  +     +E +      +  EL+ KL   
Sbjct: 2370 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2427

Query: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 6610
              LQ+   + SA+  WL+K        +    P+D + ++ +V++ +            V
Sbjct: 2428 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2486

Query: 6611 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
              +     E L+   ++PE+   +  L ++   W+         +  L +S      F  
Sbjct: 2487 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2546

Query: 6669 LSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEIS 6727
            +   L  WL     +     V  P   DP  L   R+++  L +E   R+PQ + L    
Sbjct: 2547 VEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2603

Query: 6728 NSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 6761
              +L +   +  +    +E++  + +K   L  Q+S
Sbjct: 2604 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2639



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)

Query: 585  LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
            L  W T+ E L    +    + K  EI+      L    L H +    +N+AGN L+E S
Sbjct: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362

Query: 640  NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
                 S++  +L  LN+RW+ ++ KT+         +KQ           L    +    
Sbjct: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4404

Query: 700  FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
            F  ++     E+  Q +   E+H   ++   G  + AK  E+L   +E+  A EAK    
Sbjct: 4405 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4453

Query: 759  QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
                    EE+ K L+ KG  M       +E  +  DI N+  +E ++ V     + K+ 
Sbjct: 4454 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4498

Query: 818  EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
            E K K++                   L++ ++   S ++  +++ +A+Q L     P  +
Sbjct: 4499 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541

Query: 878  -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
                   I +HK     + S+ + + +  K    LK    +   + ++     V ++WE 
Sbjct: 4542 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4601

Query: 929  LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
            +       VQ+L   +E+G+  D+  K  KQ ++   KL+       K L  E E     
Sbjct: 4602 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4651

Query: 986  EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
            +    QL  H E  + L  +     +     R LK+
Sbjct: 4652 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4687



 Score = 43.9 bits (102), Expect = 0.006
 Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)

Query: 6541 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6600
            Q L +        QQ++ D  A   WL   + E           D+  +E  +K  ++  
Sbjct: 2753 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2807

Query: 6601 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6658
            K   T ++ +    ++  E   L+T+  E   LQ +L  +   W+     V      L++
Sbjct: 2808 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2866

Query: 6659 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6718
            SL +   + +  + L  W+   +N  ++        DP        +L  L+KE+ +   
Sbjct: 2867 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2923

Query: 6719 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6778
             V++L   +NSLL     +  +  +E   +I+ K+  + EQ+      L   +N      
Sbjct: 2924 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 2979

Query: 6779 SFDEV 6783
             F EV
Sbjct: 2980 EFQEV 2984



 Score = 41.6 bits (96), Expect = 0.028
 Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
            W+ ++ + ++ + K++  L    Q    +  +  WL  TE    +L   KP   D + IE
Sbjct: 4272 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4328

Query: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
            + + +   +      +++ V +VN +  + +++ +  E++ LQ++L  L+  W+      
Sbjct: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
            +  +  L  +L Q + FH   ++L  WL   +      H+   K     L E  +E + +
Sbjct: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4442

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6755
              E+       +  +E   SL+ KG                +D    +EK   +E KL +
Sbjct: 4443 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499

Query: 6756 LREQVSQDL 6764
             + ++ + L
Sbjct: 4500 RKTKLEEAL 4508



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 17/259 (6%)

Query: 6554 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6611
            QQ +    A  +W+ +TE +L  L   +   D    +L+V++    EIL+  D    LV 
Sbjct: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3804

Query: 6612 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6671
            S     K        E   ++ +L ++   ++            L ++      F +  +
Sbjct: 3805 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861

Query: 6672 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
             L  WL   ++    + +  P  +   L + + E  QL + + E +P +D + +    LL
Sbjct: 3862 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3919

Query: 6732 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL-----QGTQ---NPASPLPSFDE- 6782
                GE     +EK    +    Q++E V +  +AL     Q TQ        L S +  
Sbjct: 3920 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978

Query: 6783 VDSGDQPPATSVPAPRAKQ 6801
            V+   QPP+ S    + K+
Sbjct: 3979 VERLRQPPSISAEVEKIKE 3997



 Score = 37.0 bits (84), Expect = 0.68
 Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)

Query: 6535 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6587
            W +   ++ H++ ++ Q    N +    D   +  WL +   +L  L +    ++    Q
Sbjct: 3504 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3563

Query: 6588 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6647
            + ELRV +   +L+  +  +AL+  + +      QT   E   +Q +L  +   ++    
Sbjct: 3564 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3619

Query: 6648 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6707
                    L Q+L   +  H   + L  WL   +           K +  +  + R +  
Sbjct: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3677

Query: 6708 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6760
            +L+KE    +  +D L E+S++LL        +G  +   E  E+  ++   + Q  E++
Sbjct: 3678 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3737

Query: 6761 SQDLMALQ 6768
               ++  Q
Sbjct: 3738 DAAILRSQ 3745



 Score = 36.2 bits (82), Expect = 1.2
 Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)

Query: 310  KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
            K+++++L K  +++ Y ++       ME  N + +  L  ++ + D   +    ++L+  
Sbjct: 4218 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4271

Query: 370  WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
            WD L+ +I   + KL  AL         L +  AWL   E L+ E      D  +A+ + 
Sbjct: 4272 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4330

Query: 423  ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
                  +Q  +   +S ++      N L+     +E ++L     NKLE + +R  N+LE
Sbjct: 4331 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4386

Query: 476  K 476
            K
Sbjct: 4387 K 4387



 Score = 35.8 bits (81), Expect = 1.5
 Identities = 33/191 (17%), Positives = 88/191 (46%), Gaps = 18/191 (9%)

Query: 6549 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 6605
            + QNL  +++N   +  +  W+ + + +L+  +     SD+  +E  ++  + + +A + 
Sbjct: 594  LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 650

Query: 6606 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQD 6665
            +++ +    +S    +Q  +P       +L +L    E+    + +      + L    +
Sbjct: 651  FESSLKEAKISE---IQMTAPLKLTYAEKLHRL----ESQYAKLLNTSRNQERHLDTLHN 703

Query: 6666 FHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLEKELVERQPQVDMLQ 6724
            F   + N L+WL    N +++  V    ++    +  +++   +L +EL +++  +  +Q
Sbjct: 704  FVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQ 759

Query: 6725 EISNSLLIKGH 6735
            EI+  LL++ H
Sbjct: 760  EIAEQLLLENH 770



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)

Query: 6624 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6683
            +S  +  L+  L  ++  W+     V      L+++L+ C  F    ++LL W+   +  
Sbjct: 3269 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3326

Query: 6684 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6743
               A+   P A+ + +    +E   L++ L +R+  V++++     +       D ++  
Sbjct: 3327 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3386

Query: 6744 EKVHVIEKKLKQLREQVSQDLMALQG 6769
            +++ +++ + + L  +       L+G
Sbjct: 3387 KQLSLLDSRWEALLNKAETRNRQLEG 3412


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  234 bits (596), Expect = 3e-60
 Identities = 773/4265 (18%), Positives = 1646/4265 (38%), Gaps = 558/4265 (13%)

Query: 2357 LNSILKSKRSTEKKGKFTLPGREKQATSDVQ-------ESTQESAA-----VEKLEEDWE 2404
            +N I + + S     K  LPG  +Q  S++Q       E +QES       + +LE++  
Sbjct: 657  INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 716

Query: 2405 INKDSAVEMAMSKQLS--------------LNAQESMKNTEDERKVNELQNQPLELDTML 2450
            + K    E+  S +                 N +  ++N ED R + +++  PLE D + 
Sbjct: 717  VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED-RLIRQIRT-PLERDDLH 774

Query: 2451 RNE-QLEEIEKLYTQLEAKKAAIKPLEQT--ECLNKTETGA----------LVLHNIGY- 2496
             +  ++ E EKL  +LE  K  +  +     E  ++    +          +VL N+   
Sbjct: 775  ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 834

Query: 2497 ---SAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDS 2553
               S+ ++D L    + LK N ++   +++ ++  L   E    A++ DK +++      
Sbjct: 835  YSMSSTYIDKLKTVNLVLK-NTQAAEALVKLYETKLCEEE----AVIADKNNIE------ 883

Query: 2554 VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIK---------QLE 2604
               +  +K++ + +++++     L+ + +       +M K   E  +          QL 
Sbjct: 884  -NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV 942

Query: 2605 HGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQS 2664
              W+ V  QI  +      + +     +   +DT   L    Q ++   +  +E     S
Sbjct: 943  ERWQNVHVQIDNRLR----DLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 998

Query: 2665 MIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
               L T L   K   S      E++MK+   ++ +K  E     +K             +
Sbjct: 999  K-TLATQLNQQKMLVS------EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051

Query: 2725 NQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVES 2784
            +Q K    R +M+ +         +L      L   +    +  K   D +   ++  +S
Sbjct: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKS 1108

Query: 2785 LAEEVKDKVPSLTTYEG--SDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAI 2842
            L EE K+ V      +   S+++ TL+D     +    K    S+++  K E+ S     
Sbjct: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168

Query: 2843 IRKFQLM-------------------VQESETLI----IPRVETAATEAELKHHHVTLEA 2879
            I+ F                      +QES  L+    + +++ + T  ++K     +  
Sbjct: 1169 IQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAE 1228

Query: 2880 SQKELQEIDSGISTHLQELTNIYEELNVFERLFLED---QLKNLKIRTNRIQRFIQNTCN 2936
             Q+E +E   GI   L +  N    +   E   + D   +LK  + +   +Q+ +Q +  
Sbjct: 1229 RQQEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQ 1286

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSI-QRNELLLNQEVNKG-VKEEIYNLK--------D 2986
             +   +K    F      L+E  + + Q ++ L+ Q++N+  +K E  NLK        D
Sbjct: 1287 ALAEVVKNTENF------LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELD 1340

Query: 2987 RL--TAIK------CCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQL 3038
            ++  TAIK        + Q+ + K   + + L+W  S +D+   +   K K++   I+Q 
Sbjct: 1341 KVVTTAIKEETEKVAAVKQLEESKTKIENL-LDW-LSNVDKDSERAGTKHKQV---IEQN 1395

Query: 3039 DT-FEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCL 3097
             T F+E  GK         AI  + +    ++    D    + + N   L+Q+ +K K  
Sbjct: 1396 GTHFQEGDGK--------SAIGEEDEVNGNLLETDVDGQVGTTQEN---LNQQYQKVKAQ 1444

Query: 3098 CDEIIKKLNENKTFDDSFKEKEILQIK----LNAEENDKLYKVLQNMVL--ELSPKELDE 3151
             ++II   ++++    + +  ++L  K    L+ EE +KL K ++ + +  E +  E ++
Sbjct: 1445 HEKII---SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1501

Query: 3152 K-----NCQDKLETSLHVLNQIKSQLQQPL--LINLE-----IKHIQNEKDNCEAFQEQV 3199
            K     + Q++LE       + +  LQQ    L NLE     I  +  +    ++F E V
Sbjct: 1502 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1561

Query: 3200 WAEMCSIKAVTAIEKQ--------------REENSSEASDVETKLREFEDLQMQLNTSID 3245
             +    ++ +T    +              + + S+   +V+ KL    D    L +  +
Sbjct: 1562 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1621

Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEA-----IIIPYRVDVGNPEESLEMPLRKQ 3300
            +  N L D  +    Y++A    +  + + EA     +  P  VD  N +  LE     Q
Sbjct: 1622 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 1681

Query: 3301 EELESTVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE 3355
             ++ S    ++ L +   ++     S   AK  +Q TL ++V +   + ++   +  + +
Sbjct: 1682 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 1741

Query: 3356 RYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKE 3415
              L      +   +++   +  +E+ L +    +PL+     + + ++  L  ++   + 
Sbjct: 1742 ITLTRSLSVQDGLDEMLDWMGNVESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 1800

Query: 3416 ELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVS 3475
             +  + + ++        +    L   +  L  ++       KE     EELK + +   
Sbjct: 1801 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--- 1857

Query: 3476 EEIEREAIILDNLQEELPEISKTKEAATTE---------ELSELL-DCLCQYGENVEKQQ 3525
                    + +NL E+L    +TK  A TE         ELS+ + +   ++ E+ +  +
Sbjct: 1858 --------LFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 1909

Query: 3526 LLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQER 3585
            +L +LL +   S   +P     V      ++  ++ ++  ++   +++ KE V +  ++ 
Sbjct: 1910 VLHSLLKEI--SSHGLPSDKALV-----LEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 1962

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK-SEQFEELQSILKKGKLTFENIME--KL 3642
             +F   + +LK++ ++TT     +      E   +  E+ + + +K  L    I +    
Sbjct: 1963 DAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2022

Query: 3643 RIKYSEMYTIV--PAEIESQVEECRKALE------DIDEKISNEVLKS--------SPSY 3686
             I    + + V  PA+  + V+     L       + +E  +N+ L S        S  Y
Sbjct: 2023 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2082

Query: 3687 A-----MRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKM--WD-------------- 3725
                  ++ KI E+N  L  ++K  ++ S  ++  Q++ K    W               
Sbjct: 2083 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2142

Query: 3726 ---------ELDLWHSKLNELDSEVQDIVEQDPG--QAQEWMDNLMIPFQQYQQVSQRAE 3774
                     EL    +K+ EL  ++ +++E++P   +A  W   L     ++Q+++Q   
Sbjct: 2143 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2202

Query: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA--NPADYDSLRTLSHHASTVQMALE 3832
             R  +L +++  + ++  +    + W+     +++   P   D    L+     VQ+ L+
Sbjct: 2203 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDP-NMLNTQRQQVQILLQ 2261

Query: 3833 DSEQKHNLLHSIFMDLED-LSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADD 3891
            +   +      +    +  LS   E   L   ++E    VT     +   L       D 
Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2321

Query: 3892 VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ 3951
             +   ++ +S+ + +S   + L +K     +   H       LE  + MK+ I       
Sbjct: 2322 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI------- 2374

Query: 3952 VELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  Q   K + V Q   + L  +   E +  E +  L+ ++K   + +++ EN  Q 
Sbjct: 2375 ------QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQH 2428

Query: 4012 LNNYSAQ-FSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLK--ATVLNLH 4068
            L +  A     + MS D    L   + E  +       L+   E L+ D K  +  L   
Sbjct: 2429 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-ESLIKDHKDFSKTLTAQ 2487

Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
             H+ ++      + L      E    +   +  K N       +   E +++ES  K+  
Sbjct: 2488 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2547

Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
              E+ E     W  + K   ++EE +                +  +NS+A++    SL  
Sbjct: 2548 YKEQVETL---WPWIDKCQNNLEEIKFCLDP-----------AEGENSIAKL---KSLQK 2590

Query: 4189 EQGPECSLRP--NQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
            E      +    N T        E D    +D    L  +V+      TE LH+ K  + 
Sbjct: 2591 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV----TEQLHSKKFCLE 2646

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQ-GLGDN 4305
             +                    Q+  E Q         E+  +    L+  K+Q  + D+
Sbjct: 2647 NMT-------------------QKFKEFQ---------EVSKESKRQLQCAKEQLDIHDS 2678

Query: 4306 GATQHEAEALSLKLKTVKCNLE--KVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNL 4363
              +Q  +      L+T + +L+  K Q+ L ++ ++D    ++ ++S+ +    +    L
Sbjct: 2679 LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQD----LVVEASDSKGTSDV----L 2730

Query: 4364 SELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQE 4423
             ++E+I  E    S+Q D ++   LE K      F   I    ++M+ Q+ + D++    
Sbjct: 2731 LQVETIAQEHSTLSQQVD-EKCSFLETKLQGIGHFQNTI----REMFSQFAEFDDELDS- 2784

Query: 4424 SSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
                              ++P G++ +  Q     + + +K      +E  +++N     
Sbjct: 2785 ------------------MAPVGRDAETLQKQKETIKAFLKK-----LEALMASNDNANK 2821

Query: 4484 SVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQC 4543
            +  M      T+ +L      LE L ++ + L  +    EE      K+L E +  L + 
Sbjct: 2822 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE- 2880

Query: 4544 LSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLL---KAMTWPGE-- 4598
                  +L+    + E      +  ET+  +L    +   ++   L    + + W G+  
Sbjct: 2881 ---FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 2937

Query: 4599 --------NTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
                    +T  L    D++    +        R+  L+  L +   +Q+ ++ L   ++
Sbjct: 2938 IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 2997

Query: 4651 KSKTSL-QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV 4709
             ++  +  Q       + V  Q+Q+       L++ +S V  ++ EGE++        +V
Sbjct: 2998 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057

Query: 4710 YKLEDV--LDSMWGML----RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHL 4763
              L+ +  LDS W  L      R  +L    V   Q    L+ + E +   +++L +   
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117

Query: 4764 ---------KQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
                     +Q     AL+  I NH     + V+    ++  S++    ++Q++  F   
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF--S 3175

Query: 4815 QVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL 4874
            QV  ++I +EKS      LQ  L   + F E+   L   L  +   L  +S+ + + E L
Sbjct: 3176 QVWYIEI-QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3234

Query: 4875 VERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE---LEGQIAKLEEQWLSLNKK 4931
             ++ S  + ++ +I  +   + Q L  G +L+   +  E   ++ ++  ++ ++  + K 
Sbjct: 3235 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3294

Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDT-IRSNINN 4990
                   L+  L+     +   ++L  WL+  +  L  ++ Q L   +     +R     
Sbjct: 3295 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK--- 3351

Query: 4991 FFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT-LRASLAQFEQKWTMLITQLPDIQE 5049
              E  KE     +L  ++  + + LL L        L   +A+  +++ ++   +    E
Sbjct: 3352 --ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3409

Query: 5050 KLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-M 5108
            ++    +      +A    +SW+   E +      +      +  +  LQ  K F ME +
Sbjct: 3410 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEIL 3467

Query: 5109 DYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHL----------GEMNRQWHRVHGML 5158
             +K  I D V      ++ C  E K+  + +  + L           E   Q  R   ++
Sbjct: 3468 RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLV 3527

Query: 5159 NRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL-QKPESVISVQKLLLDCQDIEN 5217
            N+  +  E+L   +TE+++ I    + L A     +TL Q+ E    +++L+ + +   +
Sbjct: 3528 NQFWETYEELWPWLTETQSII----SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3583

Query: 5218 QLAIKSKALDEL--------KQSYLTLESGAVPLLEDTASR---IDELFQKRSSVLTQVN 5266
            ++      L EL        ++ Y+  ++    + ED   R   +DE   + +    +++
Sbjct: 3584 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3643

Query: 5267 QLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
            Q+  S++ +++  +    +  EV  +  +    +  +K V + +E L+   E L+   +E
Sbjct: 3644 QILESLERIVERLRQPPSISAEVEKIKEQ----ISENKNVSVDMEKLQPLYETLKQRGEE 3699

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
              +  G  +K               A+ +++K       W  ++  + ++  K   +++L
Sbjct: 3700 MIARSGGTDK------------DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 3747

Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
             + +   H      +K  +   + L +  +  + + +    A + I+E    +Q+  +  
Sbjct: 3748 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQ-QQEAAETIREEIDGLQEELDIV 3806

Query: 5447 LQNSSVL----DRLPQPAESSTHMLLPGPLHSLQRA-----AYLEKMLLVKANE------ 5491
            +   S L        +P    +   L     SL +A       LE+ +            
Sbjct: 3807 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 3866

Query: 5492 -FEFV------LSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQ 5544
             F++V      L+     G  LE++K  I   ++     +QQ+ E     LNH   L   
Sbjct: 3867 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER--LNHQAELL-- 3922

Query: 5545 SPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCCE 5603
               ++ + E S K  + D     L  +   W       + R  +L+G  L   +F +  +
Sbjct: 3923 ---LKKVTEESDKHTVQD----PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 3975

Query: 5604 KWIQLLEKIEEALKVDV-ANSLPELLE-QQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
            + +  L   E  L         P+ +E +   + +L+ +V  +Q+  ++       L+++
Sbjct: 3976 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4035

Query: 5662 TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSH 5721
            +  E       +   L  RWQN ++   QRK  +DG +RQ + F   +E+L ++LTDT  
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095

Query: 5722 LLSAVKGQERFSLYQTRSLIHELKNKEIH----FQRRRTTCALTLEAGEKLLLTTDLKTK 5777
             L A K      L        E  N  +     F+ +  T    ++ G+++L       +
Sbjct: 4096 HLLASK-----PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAE 4150

Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV----ETWDQCEKKIKELKSRLQVLKAQS 5833
             ++ + I+ L++ W+ +E +L E   + +  +    E  +  +  I  L    Q L   S
Sbjct: 4151 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4210

Query: 5834 EDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEH 5893
               L  + + +  + +  K     + S  + + EL      L      +DV+++K  +  
Sbjct: 4211 RPSL--ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4268

Query: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE 5953
            +  +WE +  R+  R + ++D       F+E   +L  WL + E  +    +I+ +    
Sbjct: 4269 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4328

Query: 5954 KLQ----KDCMEEINLFSENKLQLKQMGDQLI-KASNKSRAAEIDDKLNKINDRWQHLFD 6008
            K Q    K+  + +           + G  L  K S      ++DD L+++ D+W  +  
Sbjct: 4329 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4388

Query: 6009 VIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQ 6066
                R  KL+E   F  Q    +  L  WL R+E +L+  +PV  D+     +   +   
Sbjct: 4389 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDNH 4445

Query: 6067 QDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSME 6126
            +  Q+++ + ++ V+++      L+  S       +   ++   + L  RW  +CA+S+ 
Sbjct: 4446 KAFQKELGKRTSSVQALKRSARELIEGS-----RDDSSWVKVQMQELSTRWETVCALSIS 4500

Query: 6127 RRMKIEETWRLWQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTSAKEELKRFEAF 6182
            ++ ++E   R  ++F        +WL  AE+T       P+  + L T     + + + F
Sbjct: 4501 KQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTL----IDQHKEF 4556

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
             +++ E+  +L         +      D+ + +K  +     R++ +        +RL  
Sbjct: 4557 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4616

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL----NGFQQEITLNTN 6298
                    +   E++L WL   +  LT+ +        ++++ L      F +E+T    
Sbjct: 4617 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 4676

Query: 6299 KIDQL 6303
             +D++
Sbjct: 4677 DVDKV 4681



 Score =  193 bits (490), Expect = 6e-48
 Identities = 856/4658 (18%), Positives = 1799/4658 (38%), Gaps = 724/4658 (15%)

Query: 1276 NRLEEPGN--FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
            N  EE  N  FV   L+  D   +Q    ++ +    +   ++  ++  +A+E+F +SL+
Sbjct: 271  NLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK 330

Query: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAER 1393
             AK+          S+ Q+     LT   K   +H ++       +  K+L+ S ++ ER
Sbjct: 331  EAKI----------SEIQMTAPLKLTYAEK---LHRLE------SQYAKLLNTS-RNQER 370

Query: 1394 GDDTSCENLLDAFS--IKLSETHGYGVQEEFTEENKLLEACIFKNNELLK-------NIQ 1444
              DT    +  A +  I L+E     V  +++E N  +      + EL++       NI+
Sbjct: 371  HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIK 430

Query: 1445 DVQSQISKIGLKD--PTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGRE 1502
             VQ    ++ L++    +    +R     +   +L   +  ++H++E       F D +E
Sbjct: 431  SVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKE 490

Query: 1503 KT-----------VNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLI 1551
             T               C  +  +    + LV E +E+   +L+      N      T+I
Sbjct: 491  ATDYLRNLKDAIQRKYSCDRSSSI-HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549

Query: 1552 Q--KEESVISLQASYMGKENLKKRIAEIEIVKEE-----FNEHLEVVDKINQVCKNLQFY 1604
            Q     S   L+ S   K     R  EI I K++      N H     K   +       
Sbjct: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA---KWKVISPTGNEA 606

Query: 1605 LNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW-DKLFNLKNVIDEWTE 1663
            +     F  PP  KEA       +D+  + E  Y+N+   L LW +   N+K+V+  W  
Sbjct: 607  MVPSVCFTVPPPNKEA-------VDLANRIEQQYQNV---LTLWHESHINMKSVV-SWH- 654

Query: 1664 KALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQS-SEIPLELQVMESS 1722
                    + + E DR R      +      E  + ++ +Q   +   E   E QV   S
Sbjct: 655  --------YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGS 706

Query: 1723 ILNKME-HVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFT 1781
             + ++E  V  C               +  ++L ++  +    ES+   L  S+   I  
Sbjct: 707  DITQLEKEVNVC--------------KQYYQELLKSAEREEQEESVYN-LYISEVRNIRL 751

Query: 1782 KLEEIQQQILQQKHSMIL---LENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
            +LE  + ++++Q  + +    L   +  +T E  +LKK+ E + D   T  +  ++ FS+
Sbjct: 752  RLENCEDRLIRQIRTPLERDDLHESVFRIT-EQEKLKKELERLKDDLGTITNKCEEFFSQ 810

Query: 1839 -LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSV 1897
               +          + +  N+ + +  S T                      K+K V+ V
Sbjct: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------YIDKLKTVNLV 851

Query: 1898 LKHVK--KHLPKAHVKELI--SWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHR 1953
            LK+ +  + L K +  +L     ++  +  +E + S  +    E+++  Q    L+D+  
Sbjct: 852  LKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDE-- 909

Query: 1954 NLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESV-AQLNNSLKEY-GFTEEEEI 2011
             L+K     +E +K  +E     +   +   +  E++++V  Q++N L++  G  +  + 
Sbjct: 910  -LQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKY 968

Query: 2012 IMEATCLMD----RYQTLLRQLSEIE-EEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV 2066
              +    +D    + +T  R++ E + E  K L T+      L  ++     E+K+S M 
Sbjct: 969  YRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI-----EMKQSKM- 1022

Query: 2067 LNSSEGKMPLEERIQKIKEIILLKPEGDARIET-----IMKQAESSEAPLVQKTLTDISN 2121
                E +   E+    +K+  L      A +++     + ++   S A L+ +   D+  
Sbjct: 1023 ---DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1079

Query: 2122 QWDNTLHLASTY----------LSHQEKLLLEGEK-YLQSKEDLRLMLIE----LKKKQE 2166
            ++   + L + Y          L  +EK L E +K +++  ++L+  +      LK  ++
Sbjct: 1080 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1139

Query: 2167 AGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEI 2226
            AG       +    ++   K+ L +A     L   L   G+ + +  +N    +   L+ 
Sbjct: 1140 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERNELEKQVKTLQE 1197

Query: 2227 KH--LHESLLQQLQDSVQNLDGHV---------REHDSYQVCVTDLNTTLDN---FSKEF 2272
             +  L    L+QLQ+S  + D  V         +E+      + DL T  +N     +E 
Sbjct: 1198 SYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEA 1257

Query: 2273 VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDI 2332
                D  V+    + K ++LQ+         G+ + +  + K+ +      G+K+ ++D 
Sbjct: 1258 FMIGDGTVELKKYQSKQEELQK------DMQGSAQALAEVVKNTENFLKENGEKLSQED- 1310

Query: 2333 KSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQE 2392
            K+L      +E +L  AK +   C    LK+++S ++         +K  T+ ++E T++
Sbjct: 1311 KAL------IEQKLNEAKIK---CEQLNLKAEQSKKE--------LDKVVTTAIKEETEK 1353

Query: 2393 SAAVEKLEE---------DWEINKDSAVEMAMSKQLSLNAQ----------ESMKNTEDE 2433
             AAV++LEE         DW  N D   E A +K   +  Q          +S    EDE
Sbjct: 1354 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDE 1413

Query: 2434 RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHN 2493
               N L+    ++D  +   Q E + + Y +++A+   I    Q   +  T++  ++L  
Sbjct: 1414 VNGNLLET---DVDGQVGTTQ-ENLNQQYQKVKAQHEKIISQHQAVII-ATQSAQVLLEK 1468

Query: 2494 IG--YSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPL 2551
             G   S +  + L + +  LK + E+           LA  E  MK   + +E L+    
Sbjct: 1469 QGQYLSPEEKEKLQKNMKELKVHYETA----------LAESEKKMKLTHSLQEELEKFDA 1518

Query: 2552 DSVTY---LDKIKKFIASIEKEKDSLGNLKIKW-------ENLSNH------VTDMDKKL 2595
            D   +   L + ++ + ++E   D +  L  K        E++ +H      +T    ++
Sbjct: 1519 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1578

Query: 2596 LESQIKQLEHGWEQVE-----QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQH-- 2648
            LE+     +    +V+     +++Q+K       +    +  N + +    L  + QH  
Sbjct: 1579 LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYE 1638

Query: 2649 -----LQLRLKSPEERAGNQSMIALTTD---LQATKHGFSVLKGQAELQMKRIWGEKE-- 2698
                 L   L++ E  A       +  D   LQ        L+GQ   Q   +   K+  
Sbjct: 1639 DASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTA 1698

Query: 2699 -------------KKNLEDGINNLKKQWETLEPLHLEAENQI-----KKCDIRNKMKETI 2740
                         K +++  ++++  ++E L     E   ++     +   +++ + E +
Sbjct: 1699 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 1758

Query: 2741 LWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTT 2798
             W  N+   L     +PL    +   I K  +    I  RQ S+ ++ E+VK  + +   
Sbjct: 1759 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 1818

Query: 2799 YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLII 2858
               S L   ++DL  ++     K  +   ++E +L+ +   F  + +      E++T  +
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKETLAKME-ELKTKVELFENLSEKLQTFLETKTQAL 1877

Query: 2859 PRVETAATE------------AELKHHHVTLEASQKELQEIDS-GISTHLQELTNIYEEL 2905
              V+    +            +E   H   LE     L+EI S G+ +   +   + E+ 
Sbjct: 1878 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS---DKALVLEKT 1934

Query: 2906 NVFERLF--LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQ------- 2956
            N   + F  +ED +K  K      Q  +      V+    + ++  +K   +Q       
Sbjct: 1935 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAED 1994

Query: 2957 -----EEADSIQRNELLLNQEV----NKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
                 E+   +Q    L   E+    N G+   + NL   +T     I  V     V + 
Sbjct: 1995 LGKSLEDTKKLQEKWSLKTPEIQKVNNSGI--SLCNLISAVTTPAKAIAAVKSGGAVLNG 2052

Query: 3008 IG---------LNWDFSQLDQLQTQVFEKEKE----LEEKIKQLDTFEEEHGKYQALLSK 3054
             G          N   + + +  T +    ++    L++KI +L+T   +  K Q    +
Sbjct: 2053 EGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT---KLSKLQKAQEE 2109

Query: 3055 MRAIDLQIKKMTEVVLK-----------APDSSPESRRLNAQILSQRIEKAKCLCDEIIK 3103
              A+   ++KM +   K           A  +  E  +     L Q + K + L D++ +
Sbjct: 2110 SSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE 2169

Query: 3104 KLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLH 3163
             L EN    ++ + K++L       E D  ++ L  + ++   K  +  N   + +T   
Sbjct: 2170 LLEENPDTPEAPRWKQML------TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2223

Query: 3164 VLNQ--IKSQLQQPLL--INLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTA----IEKQ 3215
             L Q  ++ +L   +L  ++++   +  ++   +   ++        + +TA    I  +
Sbjct: 2224 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2283

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
              E+ S    V+ +L         L   +  R + ++ A    T+Y+  +    + ++ L
Sbjct: 2284 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2343

Query: 3276 E-----AIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI---QDLTEKLGMISSPEAKL 3327
            +     ++ +    D  N  + LE   + ++E++     I   Q L E L       A +
Sbjct: 2344 DNKLSSSLAVSTHPDAMN--QQLETAQKMKQEIQQEKKQIKVAQALCEDL------SALV 2395

Query: 3328 QLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC-------YRKMEEDIYTNLSKMET 3380
            + +Y   EL  +   + ++FK  E +AE ++++ +        +++M  D     + ++T
Sbjct: 2396 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDT 2452

Query: 3381 VLGQSMSSLPLSYR-EALERL-----EQSKALVSNLISTKEELMKLRQILRLLRLRCTEN 3434
               +   S P+S + + LE L     + SK L +     ++ + +   +  LL+ + +E 
Sbjct: 2453 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL--LLKTQGSEK 2510

Query: 3435 DGICL-LKIVSALWE---------------------KWLSLLEAAKEWEMWCEELKQEWK 3472
              + L L  +   W+                     K+   +E    W   C+   +E K
Sbjct: 2511 AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIK 2570

Query: 3473 FVSEEIEREAII--LDNLQEELPE-----------------ISKTKEAATTEELSELLDC 3513
            F  +  E E  I  L +LQ+E+ +                 + +  +   T+E   L+  
Sbjct: 2571 FCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK 2630

Query: 3514 LCQYGENVEKQQLLLTLLLQRIRSIQNVPESSG-----AVETVPAFQEITSM--KERCNK 3566
            +    E +  ++  L  + Q+ +  Q V + S      A E +     + S     +   
Sbjct: 2631 VDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 2690

Query: 3567 LLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNM--AFQDHPEKSEQFEEL 3624
            +LQ  QK+ + ++ ++       ++++   +  + T+     +    Q+H   S+Q +E 
Sbjct: 2691 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 2750

Query: 3625 QSILK---KGKLTFENIMEKLRIKYSEMYTIVP--AEIESQVEECRKALEDIDEKISN-E 3678
             S L+   +G   F+N + ++  +++E    +   A +    E  +K  E I   +   E
Sbjct: 2751 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLE 2810

Query: 3679 VLKSSPSYA-----MRRKIEEINNGL----HNVEKMLQQKSKNIEKAQEIQKKM---WDE 3726
             L +S   A     M    EE +  L     ++E + +Q +K +++AQ  ++++      
Sbjct: 2811 ALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 2870

Query: 3727 LDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI----------------PFQQYQQ-- 3768
            L+ ++SKL E    +Q   E +  Q    M+   I                P Q  QQ  
Sbjct: 2871 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 2930

Query: 3769 ---------------------------------VSQRAECRTSQLNKATVKMEEYSDLLK 3795
                                             ++++   R +QL +A +    + D L+
Sbjct: 2931 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 2990

Query: 3796 STEAWIENTSHLLAN----PADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDL 3851
            S  +W+ +T  L+AN     A++  ++        +Q  L+D   + + +  I  + E +
Sbjct: 2991 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKI 3047

Query: 3852 SIIFETDELTQSIQELS---NQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSK 3908
            +   E  +  + +++LS   ++  AL  K      Q++ ++         ++ + + ++ 
Sbjct: 3048 ATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTT 3107

Query: 3909 IKTILLSKEIFDFSP---EEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLP 3965
            I+  L++ E         EE +   + + ++I    K + + VS    L++  +      
Sbjct: 3108 IEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3167

Query: 3966 VFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMS 4025
            V  + +        ++  +  ++ELL+  +     + E+   L   LN    + S   + 
Sbjct: 3168 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3227

Query: 4026 PDQADKLPQLQGEIERMEKQILSLNQRKEDLLVD----LKATVLNLHQHLKQEQEGVERD 4081
                + L + Q E+  +++ IL   Q  +  L++    LK T  +    ++ + E + + 
Sbjct: 3228 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KA 3286

Query: 4082 RLPAVTSEEGGVAERDASERKLNRR------GSMSYLAAVEEEVEESSVKSDNGDE--KA 4133
            R   +T     VA+      +L RR         ++L  VE E+     +   G+E  +A
Sbjct: 3287 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3346

Query: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTI------VQEAYGKISTSDNSMAQILTPD-SL 4186
            +  P+      K++K + +     SS  +       +E   K+   DN   ++++   + 
Sbjct: 3347 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3406

Query: 4187 NTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVA 4246
              E+     LR  Q ++            ++DA+       EK               + 
Sbjct: 3407 KVEEIDAAILRSQQFDQ------------AADAELSWITETEKK-----------LMSLG 3443

Query: 4247 ELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            ++ L   Q +  ++       +Q+    +++  + ++ ++      ++  C ++      
Sbjct: 3444 DIRLEQDQTSAQLQ-------VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEE------ 3490

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
                E +++  KL  V  N + +  +  E++ + +    L       ++E L P  L+E 
Sbjct: 3491 ----EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE-LWPW-LTET 3544

Query: 4367 ESIVTERP------QFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQ---HD 4417
            +SI+++ P      +  RQ+  + +Q+ EL   E K  I        K  PQ  +    +
Sbjct: 3545 QSIISQLPAPALEYETLRQQQEEHRQLREL-IAEHKPHID----KMNKTGPQLLELSPGE 3599

Query: 4418 NDTTQES--SASNQASSPENDVP------DSILSPQGQNGDKWQYLHHELSSKI-KLPLP 4468
              + QE   +A    S  + DV       D  +S   Q  DK   +   L   + +L  P
Sbjct: 3600 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3659

Query: 4469 -------QLVEPQVSTNMGILPSVTMYNFRYPTTEE-----------------LKTYTTQ 4504
                   + ++ Q+S N  +   +      Y T ++                  K    +
Sbjct: 3660 PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK 3719

Query: 4505 LEDLRQEASNLQTQENMTEEAYIN---LDKKLF----ELFLTLSQCLSSVEEMLEMPRLY 4557
            L+ +     N+ T     E   ++   L +K +     L +T+      + + LE P + 
Sbjct: 3720 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD-LEDPGID 3778

Query: 4558 REDGSGQQVHYETLALELKKLYLALS---DKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
                  QQ   ET+  E+  L   L    +   +L+ A   P  +  ++ +  D L    
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP--DKPIVKKSIDELNSAW 3836

Query: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL------IKSKTSLQQSLNEISGQSV 4668
            +    A   R   L+  +     YQ+ ++ ++  +      + S + +   L  +  Q  
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIE 3896

Query: 4669 AEQLQKADAYTVELE------NAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGM 4722
              +  K++AY  ++E       AE  + K+ +E ++    + +   + +L+ + DS+   
Sbjct: 3897 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDK----HTVQDPLMELKLIWDSLEER 3952

Query: 4723 LRARYTELSSPFVTESQ-QDALLQGMVELVK----IGKEKLAHGHLKQTKSKVALQAQIE 4777
            +  R  +L    +   Q Q AL + +  L      + ++K   G  K  + ++A    ++
Sbjct: 3953 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4012

Query: 4778 NHKVFFQKLV-----ADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMK 4832
            N  +  Q  V     A   LI++ SA    S LQN+     ++   V    EK+ Q   +
Sbjct: 4013 NDVLAHQSTVEAVNKAGNDLIES-SAGEEASNLQNKLEVLNQRWQNVL---EKTEQRKQQ 4068

Query: 4833 LQSLLQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
            L   L++ + F      L++ L      L+++ P   L E  +E+L    + + ++    
Sbjct: 4069 LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAF 4124

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPE-----LEGQIAKLEEQWLSLNKKIDHELHRLQALL 4943
              K       + +G+Q++A   CP+     ++  I  L+E+W S+  K++    +L+  L
Sbjct: 4125 EAKEETYKSLMQKGQQMLA--RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4182

Query: 4944 KHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS 5003
               + ++        WL  ++ TLN     SL     LDT+   I+    F+ EV   +S
Sbjct: 4183 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEV---NS 4235

Query: 5004 LKTAVISIGNQLLHLK----ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
             +  +I +     HLK    + D   ++  L   + +W  ++ +L +    L   +    
Sbjct: 4236 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4295

Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVN 5119
               +A ++++ W+   E + S +  +   +   ++K  L +HKEF+  +  K  + D  N
Sbjct: 4296 QFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4353

Query: 5120 QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
            ++   L   +  S   +  +  + L E+  +W  + G    +   LE+ L    +  + +
Sbjct: 4354 RTGRSLK--EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4411

Query: 5180 QILNNWLEAQEERLKTLQKPESVIS-VQKLLLDCQDIENQLAIKSKALDELKQSYLTLES 5238
            Q L +WL   E +L   Q     I  V  L+ + +  + +L  ++ ++  LK+S   L  
Sbjct: 4412 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4471

Query: 5239 GAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWY 5298
            G+     D +S +    Q+ S+    V  L  S Q+ L+      + +  V    + +  
Sbjct: 4472 GS----RDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW-- 4525

Query: 5299 CMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEK 5358
             +  ++  +     L    + L++L D+ +      E+ +  + K   +  +V  I    
Sbjct: 4526 -LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4584

Query: 5359 CQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSG 5418
               T K W  + +A  +++       Q   A + A   A   L +    + Q A  +++ 
Sbjct: 4585 SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTD 4644

Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
             +  E++P  ++++K L  + Q   E   +    +D++
Sbjct: 4645 KD-KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681



 Score =  183 bits (464), Expect = 6e-45
 Identities = 676/3660 (18%), Positives = 1402/3660 (38%), Gaps = 447/3660 (12%)

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
            +E L+   R+++E      +I ++      + + E +L  Q  ++  + ++   +  F+ 
Sbjct: 723  QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ--IRTPLERDDLHESVFRI 780

Query: 3350 QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPL-SYREALERLEQSKALVS 3408
             E E  +     K   ++++D+ T  +K E    Q+ +S  + + R  L  + Q+   V 
Sbjct: 781  TEQEKLK-----KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835

Query: 3409 NLISTKEELMKLRQIL--------RLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEW 3460
            ++ ST  + +K   ++         L++L  T+   +C  + V A      +L+   K+W
Sbjct: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK---LCEEEAVIADKNNIENLISTLKQW 892

Query: 3461 EMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGEN 3520
                +E +Q +  + +E+++   I D + +   E          +   E  D L +  +N
Sbjct: 893  RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE-----RDLDFDWHKEKADQLVERWQN 947

Query: 3521 VEKQQLLLTLLLQRIRSIQNVPESSGAVETV--PAFQEITSMKERCNKLLQKVQKNKELV 3578
            V  Q      +  R+R ++ + +S         P    I  ++    K+ +   +N + +
Sbjct: 948  VHVQ------IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1001

Query: 3579 QTEIQERHSFTKEIIALKN-------FFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKG 3631
             T++ ++     EI   ++       + +Q + + ++   Q    ++    + +S +K+ 
Sbjct: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR 1061

Query: 3632 K------LTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPS 3685
            +      L  +  M+ LR +Y+ + T++   I+   +  ++  E+  EK   E  K    
Sbjct: 1062 RMQSSADLIIQEFMD-LRTRYTALVTLMTQYIKFAGDSLKRLEEE--EKSLEEEKKEHVE 1118

Query: 3686 YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQ--- 3742
                 K +E+   + N+ K L+   K  +     QK   +E+     +L+E    +Q   
Sbjct: 1119 -----KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173

Query: 3743 -----DIVEQDPGQAQEWMDNLMIPFQQY--QQVSQRAECRTSQLNKATVKM-----EEY 3790
                  + +++  + ++ +  L   +     + + Q  E +TS   K   K+     +EY
Sbjct: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEY 1233

Query: 3791 SDLLKSTEAWIENTSHLLANPADY----DSLRTLSHHASTVQMALEDSEQKHNLLHSIFM 3846
             + L+     +  T + L    +     D    L  + S  +   +D +     L  +  
Sbjct: 1234 KEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVK 1293

Query: 3847 DLEDL-----SIIFETDE--LTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESE- 3898
            + E+        + + D+  + Q + E   +   L  K  +S  ++ ++    +  E+E 
Sbjct: 1294 NTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1353

Query: 3899 ---VKSMEKRVSKIKTIL--LSKEIFDFSPEEHLKHGEVILENIRPM-----KKTIAEIV 3948
               VK +E+  +KI+ +L  LS    D S     KH +VI +N         K  I E  
Sbjct: 1354 VAAVKQLEESKTKIENLLDWLSNVDKD-SERAGTKHKQVIEQNGTHFQEGDGKSAIGEED 1412

Query: 3949 SYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLEN--VTQEQNELL-----KVVIKQTNEW 4001
                 L       +     +  NQ  Q +K      ++Q Q  ++     +V++++  ++
Sbjct: 1413 EVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY 1472

Query: 4002 --DEEIENLKQILNNYSAQFSLEHMSPDQADKLPQ-LQGEIERMEKQILSLN---QRKED 4055
               EE E L++ +      +       ++  KL   LQ E+E+ +          Q+ E 
Sbjct: 1473 LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1532

Query: 4056 LLVDLKA---TVLNLHQHLKQEQEGVE-----RDRLPAVTSEEGGVAERDASERKLNRRG 4107
             L +L+A    +  L   LK+++   E     +  L  +T     V E   S  K  R G
Sbjct: 1533 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSK--RDG 1590

Query: 4108 SMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEE--DRASSSSGTIVQE 4165
                 +A   EV+    K D+  ++        + L  + KD+ +       +S  ++  
Sbjct: 1591 GKVDTSATHREVQR---KLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAG 1647

Query: 4166 AYGKISTSDNSMAQILTPDSLNTE---------QGPECSLRP-----NQTEE------GT 4205
                 +T+   +++ +  D  N +         QG   S +       +T E      G+
Sbjct: 1648 LQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS 1707

Query: 4206 TPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQ-------VAELELWLQQANVA 4258
              P + D   + D   G    + K+  E  E L    T+       + E+  W+     +
Sbjct: 1708 LLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESS 1767

Query: 4259 VEPE---TLNADMQQ-------VLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGAT 4308
            ++ +    LN+   Q       +LEQ + G Q+ +  +  KV   +ET            
Sbjct: 1768 LKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS-------- 1819

Query: 4309 QHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSE-LE 4367
               A +L  K+K +     +       KH E    T+ K        E  +  NLSE L+
Sbjct: 1820 --TASSLQAKMKDLSARFSEAS----HKHKE----TLAKMEELKTKVELFE--NLSEKLQ 1867

Query: 4368 SIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAK-----KMWPQYCQHD--NDT 4420
            + +  + Q   + D   + V EL    Q+   +F+E          +  +   H   +D 
Sbjct: 1868 TFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 1927

Query: 4421 TQESSASNQASSPENDVPDSILSPQG------QNGDKWQYLHHELSSKIKLPLPQLVEPQ 4474
                  +N  S    ++ D+I   +       +  D +Q L   L S IK    ++  P 
Sbjct: 1928 ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PI 1985

Query: 4475 VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNL-QTQENMTEEAYINLDKKL 4533
            V  + G               E+    T +++ +     +L      +T  A      K 
Sbjct: 1986 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2045

Query: 4534 FELFLTLSQCLSSVEEMLEMPRL--YREDGSGQQVHYETLALELKKLYLALSDKKGDLLK 4591
                L      ++ EE      L   ++D +     YE L L LK     L+ K   L K
Sbjct: 2046 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK 2105

Query: 4592 AMTWPGENTNLLLECFDNL-QVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI 4650
            A     E ++ +++    + +   +  Q  A   ++++K  ++ N+S++ E+K+  +++ 
Sbjct: 2106 AQ----EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2161

Query: 4651 KSKTSLQQSLNEISGQSVA----EQLQKADAYTVELENAE-SRVAKLRDEGERL---HLP 4702
            + K  L + L E      A    + L + D+   EL      R  KL +    L      
Sbjct: 2162 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2221

Query: 4703 YALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA--- 4759
             A L++    ++++ S+ G L      L+    T+ QQ  +L       K   E+L    
Sbjct: 2222 EAQLKQWLVEKELMVSVLGPLSIDPNMLN----TQRQQVQILLQEFATRKPQYEQLTAAG 2277

Query: 4760 HGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
             G L +     +L+            +V + L         L   L +R   W +Q    
Sbjct: 2278 QGILSRPGEDPSLRG-----------IVKEQLAAVTQKWDSLTGQLSDR-CDWIDQAIV- 2324

Query: 4820 KILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVE-ETEERLVERI 4878
                 KS Q    L+SL  K  + D   +S      + +ST P     + ET +++ + I
Sbjct: 2325 -----KSTQYQSLLRSLSDKLSDLDNKLSS-----SLAVSTHPDAMNQQLETAQKMKQEI 2374

Query: 4879 SFYQQIKRNIGGKHARLYQTLNEGKQLVASVSC--PELEGQIAKLEEQWLSLNKKIDHEL 4936
               QQ K+ I     ++ Q L E    +        EL  Q+  + + +  + +K ++ +
Sbjct: 2375 ---QQEKKQI-----KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHV 2426

Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
              LQ+       + + S     WL++ +   N    +S  +S  LD + S I +  +FSK
Sbjct: 2427 QHLQSACASSHQFQQMSRDFQAWLDTKKEEQN----KSHPISAKLDVLESLIKDHKDFSK 2482

Query: 4997 EVDEKSSLKTAVISIG-NQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
             +  +S +    I+ G N LL  + ++ A L+  L   +  W     Q+ + + KL +  
Sbjct: 2483 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2542

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
             + L  ++ +  +  W++  ++   +      P+     ++ + K K  + EMD    +V
Sbjct: 2543 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG---ENSIAKLKSLQKEMDQHFGMV 2599

Query: 5116 DFVNQ---SLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESI 5172
            + +N    SLL +   D E    E     + +  +  Q H     L    Q  ++  E  
Sbjct: 2600 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 2659

Query: 5173 TESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQS 5232
             ES+ ++Q     L+  +         + +  +Q      Q +++Q+ +  +   +L   
Sbjct: 2660 KESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL--- 2716

Query: 5233 YLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMM 5292
               +E+       D   +++ + Q+ S++  QV++  + +++ LQ    +     E+   
Sbjct: 2717 --VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 2774

Query: 5293 TIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---SEGSWEKLQEVIGKLKGLCP 5349
               F   ++   PV    ETL+ Q E +++   + E+   S  +  K  +++   +   P
Sbjct: 2775 FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSP 2834

Query: 5350 SVA------EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQ 5403
             +       E + ++C     R     + +   +++ +      K +S    +A    + 
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 2894

Query: 5404 QEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESS 5463
            Q     +   I+   N         ++ ++  Q DV    +  +Q++         A+S+
Sbjct: 2895 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA---------AKST 2945

Query: 5464 THMLLPGPLHSLQ-RAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDR 5522
            +   L   L  +  R   L K +  +A + +  L     F   LESL   ++  EE +  
Sbjct: 2946 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3005

Query: 5523 LHQQEKE--------NPDSFLNHVLALTAQSPDIEHLNEVSLKL-----PLSDVAV-KTL 5568
                  E             L  +L    +   +E +     K+     P   V + K L
Sbjct: 3006 QKPPSAEFKVVKAQIQEQKLLQRLL--DDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3063

Query: 5569 QNMNRQWIRATATALERCSELQGIGL-NEKFLYCCEKWIQLLEKIEEALK--VDVANSLP 5625
              ++ +W      A  R  +L+GI +  ++F    E   + L  IE+ L     +     
Sbjct: 3064 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3123

Query: 5626 ELLEQQKTYKMLEAEV-----SINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
            +L EQ   +K LE ++      ++Q ++   + QSL++L + E ++  +   +FS++   
Sbjct: 3124 KLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDFSQV--- 3177

Query: 5681 WQNAVQGVRQRKGDV-DGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFS--LYQT 5737
            W   +Q     + ++    +   + F      L  +L +    LS +  Q+  +  L++ 
Sbjct: 3178 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3237

Query: 5738 RSLIHELKNKEIHFQRRRTTCALT--LE-----AGEKLLLTTD-LKTKESVGRRISQLQD 5789
            +S +  L+ ++I  +++    AL   LE      G+++L+  D L+  ++  + I++L  
Sbjct: 3238 QSELRVLQ-EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3296

Query: 5790 SWKDMEPQLAEMIKQFQSTVE---TW-DQCEKKIKELKSRLQVLK----AQSEDPLPELH 5841
                   Q  ++ ++  ST E   TW D+ E ++  L    QVLK    +Q++    EL 
Sbjct: 3297 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL--LSYETQVLKGEEASQAQMRPKELK 3354

Query: 5842 EDLHNEKELIKELEQ------SLASWTQNLKELQTMKADLTRHVLVEDVMVLK-EQIEHL 5894
            ++  N K L+  L +       L  W       + +  D  R+ LV D +  K E+I+  
Sbjct: 3355 KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-- 3412

Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEK 5954
                        +R Q+          F++      +W+ + E K++   DI +E+    
Sbjct: 3413 ---------AAILRSQQ----------FDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3453

Query: 5955 LQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-------EIDDKLNKINDRWQHLF 6007
             Q   ++    F+   L+ K + D L+K+ +K   A        +  KL+K+   +  + 
Sbjct: 3454 AQ---LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTIC 3510

Query: 6008 DVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ 6067
             +   R  +L+   + + Q  +    L  WL   +S +S+ +     + + ++++  E +
Sbjct: 3511 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPALEYETLRQQQEEHR 3569

Query: 6068 DLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMER 6127
             L+  I +H   ++ +      LL  S       E  SIQ+   + D  +  I     +R
Sbjct: 3570 QLRELIAEHKPHIDKMNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKEDVKKR 3624

Query: 6128 RMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIH 6187
             + ++E      +F D   +  + L+        P S        KE++   +     + 
Sbjct: 3625 AVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDME 3684

Query: 6188 ERLTQLELINKQYRRL-ARENRTDTASRLKQMVHEGNQR---WDNLQRRVTAVLRRLRHF 6243
            +     E + ++   + AR   TD     K +  + +Q    W+N+   V     +L   
Sbjct: 3685 KLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 3744

Query: 6244 TNQREEFEGTRESILVWLTEMDLQLTNVEH--------FSESDADDKMRQ-LNGFQQEIT 6294
                E+F     S++V + +    + ++E           + +A + +R+ ++G Q+E+ 
Sbjct: 3745 MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELD 3804

Query: 6295 LNTNKIDQLIVF----GEQLIQKS--------EPLDAVLIE--DELEELHRYC------- 6333
            +  N   +LI       + +++KS        + L+    +  D+LEE  +         
Sbjct: 3805 IVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 3864

Query: 6334 QEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGESEEPS-SPQS 6392
            Q VF  V     +L S +P   D +   +    +E+ ++ ++++++++ E E  +   + 
Sbjct: 3865 QAVFDWVDIAGGKLASMSPIGTDLETVKQQ---IEELKQFKSEAYQQQIEMERLNHQAEL 3921

Query: 6393 LCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGH 6452
            L   V    ++   + P+    + L WD   +   +  H+          L G  ++ G 
Sbjct: 3922 LLKKVTEESDKHTVQDPLM--ELKLIWDSLEERIINRQHK----------LEGALLALGQ 3969

Query: 6453 SWHVPDSPSCPEHHYKQMEGDRNV----PPVPPASSTPYKPPYGKLLLPPGTDGG--KEG 6506
              H  D       H + +  ++      P         +      +L    T     K G
Sbjct: 3970 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG 4029

Query: 6507 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQ---LNSDISAI 6563
              ++  +  +E   L    E  +    RW+ +  +    K ++   L+Q    + +I  +
Sbjct: 4030 NDLIESSAGEEASNLQNKLEVLN---QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDL 4086

Query: 6564 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 6623
              WL  TE  L   K      +  + +L V    E+  AF+  +    S+    ++ L  
Sbjct: 4087 QQWLTDTERHLLASKPLGGLPETAKEQLNVH--MEVCAAFEAKEETYKSLMQKGQQML-A 4143

Query: 6624 ESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAK 6681
              P+S E  +   +  L   WE+ +  ++  +  L ++L    +FH   Q+ + WL  A+
Sbjct: 4144 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4203



 Score =  181 bits (458), Expect = 3e-44
 Identities = 668/3660 (18%), Positives = 1377/3660 (37%), Gaps = 503/3660 (13%)

Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTK 3414
            E +LEN+K   +  E+  ++L + +    Q  + L L+Y E L RLE   A    L++T 
Sbjct: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA---KLLNTS 365

Query: 3415 EELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFV 3474
                +    L     R T             +W       E A +W      + ++ K  
Sbjct: 366  RNQERHLDTLHNFVSRATNE----------LIWLNEKEEEEVAYDWSERNTNIARK-KDY 414

Query: 3475 SEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQR 3534
              E+ RE   LD  +E +  + +  E    E     L  +  Y   ++ Q   +  L Q 
Sbjct: 415  HAELMRE---LDQKEENIKSVQEIAEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQC 470

Query: 3535 IRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQK---------VQKNKELVQTEIQER 3585
            +   Q++ E++   E     +E T         +Q+         + K ++LVQ  ++E+
Sbjct: 471  VE--QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 528

Query: 3586 HSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIK 3645
                +    + N   +  T  Q       P  S+          K  +  + I +  +I+
Sbjct: 529  EELLQYKSTIANLMGKAKTIIQLK-----PRNSD-------CPLKTSIPIKAICDYRQIE 576

Query: 3646 YSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKM 3705
                 TI   +         +A   +     NE +  S  +     +   N    ++   
Sbjct: 577  I----TIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFT----VPPPNKEAVDLANR 628

Query: 3706 LQQKSKNIEKAQEIQKKMWDELDLWHSKLNELD----SEVQDIVEQDPGQAQEWMDNLMI 3761
            ++Q+ +N+             +  WH  +NE+D    S V  I    PG+ Q+ + NL  
Sbjct: 629  IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 688

Query: 3762 PFQQYQQVSQRAECRT----SQLNK-ATVKMEEYSDLLKSTEAWIENTSHLLANPADYDS 3816
             F+ + + SQ ++  +    +QL K   V  + Y +LLKS E   +  S      ++  +
Sbjct: 689  RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 748

Query: 3817 LRT-LSHHASTVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTAL- 3874
            +R  L +    +   +    ++ +L  S+F   E   +  E + L   +  ++N+     
Sbjct: 749  IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 808

Query: 3875 -QQKIMESLPQIQRMADDVVAIESEVKSMEKR-VSKIKTILL------SKEIFDFSPEEH 3926
             Q     S+P ++   + V+   ++V SM    + K+KT+ L      + E      E  
Sbjct: 809  SQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETK 868

Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQE 3986
            L   E ++ +   ++  I+ +  ++ E+       +   VF      LQ  K + +    
Sbjct: 869  LCEEEAVIADKNNIENLISTLKQWRSEVD------EKRQVFHALEDELQKAKAISD---- 918

Query: 3987 QNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQI 4046
              E+ K   ++  ++D   E   Q++  +       H+  D  ++L  L+G I +  K  
Sbjct: 919  --EMFKTYKERDLDFDWHKEKADQLVERWQNV----HVQID--NRLRDLEG-IGKSLKYY 969

Query: 4047 LSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLN-- 4104
                   +D +  ++ T     + +++ Q    +     +  ++  V+E +  + K++  
Sbjct: 970  RDTYHPLDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025

Query: 4105 RRGSMSYLAAVEE-EVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIV 4163
            ++ +  Y A V++ E++  + ++    ++  P              ++  R  SS+  I+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSP--------------VKRRRMQSSADLII 1071

Query: 4164 QEAYGKISTSDNSMAQILTP------DSLNTEQGPECSLRPNQ----------------- 4200
            QE +  + T   ++  ++T       DSL   +  E SL   +                 
Sbjct: 1072 QE-FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNI 1130

Query: 4201 ------TEEGTTPPIEADTLDSSDAQGGLEPRVEK---------------TRPEPTEVLH 4239
                   E+   PP     + S +     E   E                T  E  E+  
Sbjct: 1131 SKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEK 1190

Query: 4240 ACKTQVAELELWLQQA-----------NVAVEPETLNADMQQVLEQQLVGCQAMLTEIE- 4287
              KT      L   ++           +V VE E + A+ QQ  +++L G   +LT+ E 
Sbjct: 1191 QVKTLQESYNLLFSESLKQLQESQTSGDVKVE-EKIVAERQQEYKEKLQGICDLLTQTEN 1249

Query: 4288 ----HKVAFLL-----ETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHS 4338
                H+ AF++     E  K Q   +    Q + +  +  L  V  N E       EK S
Sbjct: 1250 RLIGHQEAFMIGDGTVELKKYQSKQEE--LQKDMQGSAQALAEVVKNTENFLKENGEKLS 1307

Query: 4339 EDQHPTILKKSSEPEHQEALQPVNLS------ELESIVTERPQFSRQKDFQQQQVLELKP 4392
            ++    I +K +E + +   + +NL       EL+ +VT   +   +K    +Q+ E K 
Sbjct: 1308 QEDKALIEQKLNEAKIK--CEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1365

Query: 4393 MEQK--DFIKFIEFNAKKMWPQYCQ--HDNDTTQESSASNQASSPENDVPDSILSPQGQN 4448
              +   D++  ++ ++++   ++ Q    N T  +      A   E++V          N
Sbjct: 1366 KIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV----------N 1415

Query: 4449 GDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDL 4508
            G+                   L+E  V   +G                     TTQ E+L
Sbjct: 1416 GN-------------------LLETDVDGQVG---------------------TTQ-ENL 1434

Query: 4509 RQEASNLQTQEN--MTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQV 4566
             Q+   ++ Q    +++   + +  +  ++ L       S EE  ++ +  +E     +V
Sbjct: 1435 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE----LKV 1490

Query: 4567 HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
            HYET         LA S+KK  L  ++          LE FD      EH    +    +
Sbjct: 1491 HYETA--------LAESEKKMKLTHSLQEE-------LEKFDADYTEFEHWLQQSEQELE 1535

Query: 4627 SLKAGLDYNRSYQNEIKR---LYHQLIKSKTSLQQSLNEISGQSV---AEQLQKADAYTV 4680
            +L+AG D       ++KR       +I  K  L+     ISG  V   A+   K D   V
Sbjct: 1536 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT--ISGNRVLEAAKSCSKRDGGKV 1593

Query: 4681 ELENAESRVAKLRDEG-ERLHLPYALLQEV-YKLEDVLDSMWGMLRARYTELSSPFVTES 4738
            +       V +  D   +R    Y+    +   L+D++D         Y + S   +   
Sbjct: 1594 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY-----QHYEDASCGLLAGL 1648

Query: 4739 Q--QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796
            Q  +    + + E + +  + L    L++TK   ALQ QI + +V  +KL     ++   
Sbjct: 1649 QACEATASKHLSEPIAVDPKNLQR-QLEETK---ALQGQISSQQVAVEKLKKTAEVLLDA 1704

Query: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856
               +LP+    ++T   + V   + L +   +   KLQ  L +     +    +   +  
Sbjct: 1705 RGSLLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 1763

Query: 4857 LISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASV---SCPE 4913
            + S+L     V      L + IS    ++++I G+ + +     + K+ + +    +   
Sbjct: 1764 VESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASS 1823

Query: 4914 LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQ 4973
            L+ ++  L  ++   + K    L +++ L   +  +   S++L  +LE+    L      
Sbjct: 1824 LQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 1883

Query: 4974 SLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQF 5033
              +V++    ++ + + F E  K ++   SL   + S      H   +D A +       
Sbjct: 1884 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISS------HGLPSDKALVLEKTNNL 1937

Query: 5034 EQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS-SAS 5092
             +K+  +   + + +E +   Q +    +  +  + SW+     +T+ +  +  PS  A 
Sbjct: 1938 SKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIK----ETTKKVPIVQPSFGAE 1993

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL---------------------STCDVE 5131
             +   L+  K+ + +   K   +  VN S + L                     +  + E
Sbjct: 1994 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2053

Query: 5132 SKRYERTEFAEHLG---------EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
                   EF  + G         +++  +  +  +L  KI  L   L  + +++ +   +
Sbjct: 2054 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2113

Query: 5183 NNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL--- 5236
              WL+   +     Q+   P    +V+  +   +  E +L      + ELK     L   
Sbjct: 2114 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2173

Query: 5237 --ESGAVPLLEDTASRIDELFQK-------RSSVLTQVNQLKTSMQSV---LQEWKIYDQ 5284
              ++   P  +   + ID  +Q+       R   L + +   T  Q+V   L++W +  +
Sbjct: 2174 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2233

Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL----QEV 5340
            L   V               P+ +    L  Q + +Q L  E  + +  +E+L    Q +
Sbjct: 2234 LMVSV-------------LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2280

Query: 5341 IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR 5400
            + +  G  PS+  I++E+     ++W  +   ++D+       +     Y +     + +
Sbjct: 2281 LSR-PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2339

Query: 5401 LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK--EAFLQNSSVLDRLPQ 5458
            L   + K      +S   + + + L  A +  +E+Q + ++ K  +A  ++ S L +  +
Sbjct: 2340 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK-EE 2398

Query: 5459 PAESSTHMLLPGPLHSL----QRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
              ++     L G L S     Q+A  +++ +    A+  +F     +DF   L++ K   
Sbjct: 2399 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQ-QMSRDFQAWLDTKK--- 2454

Query: 5514 MHEEEN--------LDRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLS 5561
              EE+N        LD L    K++ D        LTAQS   E        + LK   S
Sbjct: 2455 --EEQNKSHPISAKLDVLESLIKDHKD----FSKTLTAQSHMYEKTIAEGENLLLKTQGS 2508

Query: 5562 DVAVKTLQ--NMNRQWIRATATALERCSELQGIGLNEKFLYCCEK------WIQLLEKIE 5613
            + A   LQ   +   W        ER ++L+     EK L   E+      WI   +   
Sbjct: 2509 EKAALQLQLNTIKTNWDTFNKQVKERENKLKES--LEKALKYKEQVETLWPWIDKCQNNL 2566

Query: 5614 EALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRP 5668
            E +K      +  NS+ +L   QK        V +    A+S       LL   EI+   
Sbjct: 2567 EEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANS-------LLSVCEIDK-- 2617

Query: 5669 EFITEFSK-LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLS--- 5724
            E +T+ +K L  +     + +  +K  ++ + +++++F    +   R L      L    
Sbjct: 2618 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 2677

Query: 5725 AVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRI 5784
            ++  Q   + Y T   + + + K +   + +   A  L A + ++  +D K    V  ++
Sbjct: 2678 SLGSQAYSNKYLT---MLQTQQKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQV 2733

Query: 5785 SQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHE 5842
              +      +  Q+ E     ++ ++     +  I+E+ S+      +  S  P+    E
Sbjct: 2734 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 2793

Query: 5843 DLHNEKELIKELEQSL-ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDL 5901
             L  +KE IK   + L A    N    +T K  L       D++ +K  +E L +Q   L
Sbjct: 2794 TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKL 2853

Query: 5902 CLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE--------EMIE 5953
              R   R++++E  +     F  K KE    L + E        + +E         M +
Sbjct: 2854 LDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFK 2913

Query: 5954 KLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE-IDDKLNKINDRWQHLFDVIGS 6012
              QK   EEI      +  +  +G  LI+++ KS + + ++  L+ +N RW+ L   +  
Sbjct: 2914 VFQK---EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQ 2970

Query: 6013 RVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRD 6072
            R  +L+E      +    + +L +W+   E EL         + + ++ ++ EQ+ LQR 
Sbjct: 2971 RAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPPSAEFKVVKAQIQEQKLLQRL 3029

Query: 6073 IEQHSAGVESVFNICDVLLHDSDACANETE-CDSIQ--QTTRSLDRRWRNICAMSMERRM 6129
            ++   + VE       V+  + +  A   E  D ++  +    LD RW  +   +  R  
Sbjct: 3030 LDDRKSTVE-------VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNR 3082

Query: 6130 KIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQI--- 6186
            ++E    + Q+F +      +WL + E+            +  +E++ + +A +  I   
Sbjct: 3083 QLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3142

Query: 6187 HERLTQLELINKQYRRLA-RENRTDTASRLKQMVHEGNQRWD-NLQRRVTAVLRRLRHFT 6244
            ++ L Q   I +  + L+ RE++    S+L     + +Q W   +Q +  +    L+   
Sbjct: 3143 NKHLHQAVSIGQSLKVLSSREDKDMVQSKL-----DFSQVWYIEIQEKSHSRSELLQQAL 3197

Query: 6245 NQREEFEGTRESILVWLTEMDLQLT--NVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
               + F      ++ WL E+  +L+  +V+ +S      +  +L   Q++I L    +DQ
Sbjct: 3198 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3257

Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV----------FGRVSRFHRRLTS--- 6349
             ++ G +L++++   + ++I+D+LE +    +++            +  +  RRL S   
Sbjct: 3258 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3317

Query: 6350 --CTPGLEDEKEASENETDM----------EDPREIQTDSWRKRGESEEPSSPQSLCHLV 6397
              CT   + E E    ET +            P+E++ ++   +   +  +   S    +
Sbjct: 3318 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3377

Query: 6398 APGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVP 6457
             P   R G E  V+ D+   E         +   EE +     S    ++     SW   
Sbjct: 3378 VPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3434

Query: 6458 DSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQE 6517
                       ++E D+    +    +   +    K ++    D  K G +++    ++E
Sbjct: 3435 TEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII---DDLVKSGHKIMTACSEEE 3491

Query: 6518 DGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEML 6577
               +    ++    +D    I ++      + +  + Q       +  WL +T++ +  L
Sbjct: 3492 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3551

Query: 6578 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
                P  + + +  + +  +++ +    +K  +  +N +  + L+    E   +Q +   
Sbjct: 3552 --PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3609

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADP 6696
               L+   +  V      L +++ Q   FH     +L  L     R RQ   ++   A+ 
Sbjct: 3610 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS---AEV 3666

Query: 6697 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              + E   E   +  ++ + QP  + L++    ++ +  G D    +     ++ KL Q+
Sbjct: 3667 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD---KDISAKAVQDKLDQM 3723



 Score =  174 bits (440), Expect = 4e-42
 Identities = 317/1673 (18%), Positives = 674/1673 (40%), Gaps = 183/1673 (10%)

Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
            LQ Q E  K F +KL A ++     + K    +L   ET   + V   + LE  S+QC  
Sbjct: 2795 LQKQKETIKAFLKKLEA-LMASNDNANKTCKMMLATEETS-PDLVGIKRDLEALSKQCN- 2851

Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGK 4891
                LL + +  +E      K LE   S L   S+       L+++   +++ +  +G +
Sbjct: 2852 ---KLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI-------LLQKAEEHEESQGPVGME 2901

Query: 4892 HARLYQTLN-------------EGKQ-------------LVASVSCPELEGQIAKLEEQW 4925
               + Q LN             +GKQ                S S   LE  +  +  +W
Sbjct: 2902 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 2961

Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
             +LNKK+     +LQ  L H   +    + L  W+  ++  +   K  S     +   ++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVK 3017

Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQL 5044
            + I       + +D++ S    +   G ++    E  D   +   L+  + +W  L+ + 
Sbjct: 3018 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3077

Query: 5045 PDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF 5104
                 +L  + +      + +  +  W+  +E +  + + + +   AS+++  + +HK  
Sbjct: 3078 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT--QASKLEEQIAQHKAL 3135

Query: 5105 RMEM-DYKQWIVDFVN--QSLLQLSTCDVESKRYERTEFAEHLGEMNRQWH-RVHGMLNR 5160
              ++ ++ + +   V+  QSL  LS+ + +     + +F++        W+  +    + 
Sbjct: 3136 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ-------VWYIEIQEKSHS 3188

Query: 5161 KIQHLEQLL-ESITESENKIQILNNWLEAQEERLKTL------------QKPESVISVQK 5207
            + + L+Q L  +    E++++++N WL    ++L  L            Q+ E  +  + 
Sbjct: 3189 RSELLQQALCNAKIFGEDEVELMN-WLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQED 3247

Query: 5208 LLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ 5267
            +LL  Q+++  L      L+ LKQ+        V +++D    I   ++  + + T V +
Sbjct: 3248 ILLRKQNVDQALL---NGLELLKQT----TGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300

Query: 5268 -LKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
             L+ ++Q   +    +++L   ++ + +     + +   V+   E  + Q+   + L+ E
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVEL---LSYETQVLKGEEASQAQMRP-KELKKE 3356

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQ 5385
            A++++   + L EV   L  L P  A E +E+     ++R+  V+  I  ++++  + + 
Sbjct: 3357 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3416

Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKT-KE 5444
              + +  A     + + + E K   L +I +             QD    Q  VQKT   
Sbjct: 3417 RSQQFDQAADAELSWITETEKKLMSLGDIRLE------------QDQTSAQLQVQKTFTM 3464

Query: 5445 AFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGV 5504
              L++  ++D L +    S H ++     S +    ++K L      ++ +     +  +
Sbjct: 3465 EILRHKDIIDDLVK----SGHKIMTAC--SEEEKQSMKKKLDKVLKNYDTICQINSERYL 3518

Query: 5505 RLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVA 5564
            +LE  + L+    E  + L     E   S ++ + A   +   +    E   +L      
Sbjct: 3519 QLERAQSLVNQFWETYEELWPWLTET-QSIISQLPAPALEYETLRQQQEEHRQLRELIAE 3577

Query: 5565 VKT-LQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKI-------EEAL 5616
             K  +  MN+     T   L   S  +G  + EK++     + Q+ E +       +EA+
Sbjct: 3578 HKPHIDKMNK-----TGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAI 3632

Query: 5617 --------KVD-VANSLPELLEQQKTYKMLEAEVS-INQTIAD----SYVTQSLQLLDTT 5662
                    K+D +  SL  ++E+ +    + AEV  I + I++    S   + LQ L  T
Sbjct: 3633 SQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYET 3692

Query: 5663 EIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN----------- 5711
             ++ R E +   S  TD+  +A    +  +  +D +V  W++  T VE            
Sbjct: 3693 -LKQRGEEMIARSGGTDKDISA----KAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 3747

Query: 5712 LFRFLTDTSHLLSAVKGQERF-----------SLYQTRSLIHELKNKEIHFQRRRTTCAL 5760
              +F  D   L+  +K  + F           S+ + +    E   +EI   +      +
Sbjct: 3748 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 3807

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
             L  G +L+       K  V + I +L  +W  +     + I + +  ++   Q +  ++
Sbjct: 3808 NL--GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 3865

Query: 5821 ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTM--KADLTRH 5878
             +   + +   +     P +  DL   K+ I+EL+Q  +   Q   E++ +  +A+L   
Sbjct: 3866 AVFDWVDIAGGKLASMSP-IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK 3924

Query: 5879 VLVE--DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQM 5936
             + E  D   +++ +  L   W+ L  R+  R+ ++E  L     F     EL AWL   
Sbjct: 3925 KVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 3984

Query: 5937 ENKVLQTADISIEEM---IEKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEI 5992
            E  + +   +  +     IE  +   ++   L  ++ ++ + + G+ LI++S    A+ +
Sbjct: 3985 EGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL 4044

Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVV 6050
             +KL  +N RWQ++ +    R ++L       +     + +L+ WL   E  L  SKP+ 
Sbjct: 4045 QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL- 4103

Query: 6051 YDVCDDQEIQKRLAEQQDLQRDI-EQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
                    + +   EQ ++  ++     A  E+  ++          C    E + I Q 
Sbjct: 4104 ------GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN-IDQD 4156

Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
              +L  +W ++     ER+ K+EE   L  +F +    F +WL  AE+T    +   ++ 
Sbjct: 4157 INNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL 4216

Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNL 6229
             +   ++   + F  +++    Q+  ++K    L   ++      +K ++     RW+ +
Sbjct: 4217 DTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4276

Query: 6230 QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQL-TNVEHFSESD-ADDKMRQLN 6287
             +R+    R L     + ++F      ++ WL E +  L + +E  ++ D    ++ Q  
Sbjct: 4277 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4336

Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVL-IEDELEELHRYCQEVFGR 6339
             FQ+ +    +  D     G  L +K+   D  L ++D L EL      + G+
Sbjct: 4337 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4389



 Score =  160 bits (404), Expect = 5e-38
 Identities = 895/4730 (18%), Positives = 1801/4730 (38%), Gaps = 714/4730 (15%)

Query: 1734 LTGESNCHALS-GSTAELREDLDQAKTQ---IGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
            LT  S    LS G T+ L   +  A T     G+  +    + P+ SL+   KL +I++ 
Sbjct: 204  LTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPN-SLQTL-KLMQIRKP 261

Query: 1790 ILQQKHSMI---LLENQIGC-----LTPELSELKKQYESV---SDLFNTKKSVLQDHFSK 1838
            +L  K S++   L E +I       L   + E++ Q +     SDL + + S L++H   
Sbjct: 262  LL--KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE-SHLENH--- 315

Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
                  KN +      + +LKE  + SE + +   KL        LE + +K+       
Sbjct: 316  ------KNVHRAIEEFESSLKEA-KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS--- 365

Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
            ++ ++HL   H    +S    +   L + E   +  A +  +    + R +D H  L + 
Sbjct: 366  RNQERHLDTLH--NFVSRATNELIWLNEKEE--EEVAYDWSERNTNIARKKDYHAELMRE 421

Query: 1959 LTNQEEKWKGMEEPGEK-------TELFCQAL-ARKREQFESVAQLNNSLKEY-----GF 2005
            L  +EE  K ++E  E+         L  +A  A  + Q+  + QL   ++++      +
Sbjct: 422  LDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAY 481

Query: 2006 TEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTED--QSFNDLAHDVIHWIKEIK-- 2061
             E      EAT  +   +  +++    +    +   ED  Q   +   +++ +   I   
Sbjct: 482  FEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANL 541

Query: 2062 ----ESLMVLNSSEGKMPL---------------EERIQKIKEIILLKPEGDARIETIMK 2102
                ++++ L       PL               E  I K  E +L      A+ + I  
Sbjct: 542  MGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601

Query: 2103 QAESSEAPLV-------QKTLTDISN----QWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
                +  P V        K   D++N    Q+ N L L   + SH     +    YL ++
Sbjct: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL--WHESHINMKSVVSWHYLINE 659

Query: 2152 ED-LRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQ--------DLTSLLKEL 2202
             D +R   +   K    G   +H       Q + ++ FL+ +Q        D+T L KE+
Sbjct: 660  IDRIRASNVASIKTMLPG---EHQQVLSNLQSR-FEDFLEDSQESQVFSGSDITQLEKEV 715

Query: 2203 KSQGNYLLECTKNPSFSEEPW--------------LEIKHLHESLLQQLQDSVQNLDGH- 2247
                 Y  E  K+    E+                L +++  + L++Q++  ++  D H 
Sbjct: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775

Query: 2248 ----VREHDSYQVCVTDLNT---TLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLS 2300
                + E +  +  +  L     T+ N  +EF S +        +  +L  + +  N++ 
Sbjct: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835

Query: 2301 LQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI 2360
                T    L     V +NT +    +   + K  +      E  + + K  +E  + S 
Sbjct: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCE------EEAVIADKNNIENLI-ST 888

Query: 2361 LKSKRST--EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK-DSAVEMAMSK 2417
            LK  RS   EK+  F     E Q    + +   ++     L+ DW   K D  VE   + 
Sbjct: 889  LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948

Query: 2418 QLSLNAQ--------ESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
             + ++ +        +S+K   D    +++   Q       ++  Q E  + L TQL  +
Sbjct: 949  HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008

Query: 2469 KAAIKPLEQT-----ECLNKTETGALV-----LHNIGYSAQHLDNLLQALITLKKNKESQ 2518
            K  +  +E       EC    E  +       L  + Y A  +D+  ++ +  ++ + S 
Sbjct: 1009 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAM-VDSQQKSPVKRRRMQSSA 1067

Query: 2519 YCVLRDFQE--------------YLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFI 2564
              ++++F +              Y+     S+K L  +++SL+    + V    +++K++
Sbjct: 1068 DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWV 1127

Query: 2565 ASIEKE--------KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQK 2616
            ++I K         K      KI  E +S     + + L   Q+   +HG +  +++ + 
Sbjct: 1128 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE-RN 1186

Query: 2617 KYSQQVVEYDE-----FTTLMNKVQDTEIS--LQQQQQHLQLRLKSPEERAGNQSMIALT 2669
            +  +QV    E     F+  + ++Q+++ S  ++ +++ +  R +  +E+      +   
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246

Query: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK----------------KNLEDGINNLKKQW 2713
            T+ +   H  + + G   +++K+   ++E+                KN E   N LK+  
Sbjct: 1247 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1303

Query: 2714 ETL-------------------EPLHLEAENQIKKCD--IRNKMKETI--LWAKNLLGEL 2750
            E L                   E L+L+AE   K+ D  +   +KE    + A   L E 
Sbjct: 1304 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1363

Query: 2751 NPSIPLLPD---DILSQIRKCKVTHDGILARQ-------QSVESLAEEVKDKVPSLTTYE 2800
               I  L D   ++     +    H  ++ +            ++ EE +     L T  
Sbjct: 1364 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1423

Query: 2801 GSDLNNTLEDLRNQYQML-------------VLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
               +  T E+L  QYQ +             V+ +TQ +Q L   LE++  + +   K +
Sbjct: 1424 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVL---LEKQGQYLSPEEKEK 1480

Query: 2848 LMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNV 2907
            L     E  +      A +E ++K  H    + Q+EL++ D+  +     L    +EL  
Sbjct: 1481 LQKNMKELKVHYETALAESEKKMKLTH----SLQEELEKFDADYTEFEHWLQQSEQELEN 1536

Query: 2908 FERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNE- 2966
             E     D +  L  +  R + F ++    + HK    R      + + E A S  + + 
Sbjct: 1537 LEAG--ADDINGLMTKLKRQKSFSEDV---ISHKGDL-RYITISGNRVLEAAKSCSKRDG 1590

Query: 2967 -LLLNQEVNKGVKEEIYNLKDRLTAI--KCCILQVLKLKKVFDYIGLNWDFS--QLDQLQ 3021
              +     ++ V+ ++ +  DR  ++  KC +L    LK + D      D S   L  LQ
Sbjct: 1591 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN-NLKDLVDKYQHYEDASCGLLAGLQ 1649

Query: 3022 TQVFEKEKELEEKI----KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP 3077
                   K L E I    K L    EE    Q  +S  +    ++KK  EV+L A  S  
Sbjct: 1650 ACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGS-- 1707

Query: 3078 ESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL 3137
                    +L  + +  K L D+I+ +  +     +   EK  + +  +    D L ++L
Sbjct: 1708 --------LLPAKNDIQKTL-DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 1758

Query: 3138 QNMV-LELSPKE-----LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDN 3191
              M  +E S KE     L+    QD +  ++ +   I  +      +N ++K      D 
Sbjct: 1759 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 1818

Query: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
              A   Q   +  S +   A  K +E   ++  +++TK+  FE+L  +L T ++ +T  L
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKE-TLAKMEELKTKVELFENLSEKLQTFLETKTQAL 1877

Query: 3252 NDA------YENLTRY-KEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQEE 3302
             +          L++Y +E+ +  +E    LE +  ++      G P +   + L K   
Sbjct: 1878 TEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA-LVLEKTNN 1936

Query: 3303 LESTVAHIQD-LTEKLGMISSPEAKLQ--------LQYTLQELVSKNSAMKEAFKAQETE 3353
            L      ++D + EK   ++S + +L         L+  ++E   K   ++ +F A++  
Sbjct: 1937 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 1996

Query: 3354 AERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS-----SLPLSYREALERLEQSKALVS 3408
              + LE+ K   K++E       +++ V    +S     S   +  +A+  ++   A+++
Sbjct: 1997 --KSLEDTK---KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2051

Query: 3409 NL-ISTKEELMKLRQILRLLRLRCT------ENDGICLLKIVSALWEKWLSLLEAAKEWE 3461
                +T  E     + L  ++   T      E+ G+ L   ++ L  K   L +A +E  
Sbjct: 2052 GEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS 2111

Query: 3462 ---MWCEELKQ---EWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLC 3515
                W +++ +   +W+      + EA+     Q +  E    +     +EL + L  L 
Sbjct: 2112 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL 2171

Query: 3516 QYGENV--------------EKQQLLLTLLLQRIRSIQNVPESSGAVETVPA-FQEITSM 3560
            +   +                K Q L  L + R + ++    +    +TV A  ++    
Sbjct: 2172 EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2231

Query: 3561 KERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQ 3620
            KE    +L  +  +  ++ T+ Q+     +E    K  ++Q T + Q +  +   + S +
Sbjct: 2232 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLR 2291

Query: 3621 F---EELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISN 3677
                E+L ++ +K       + +  R  + +   +   + +S +      L D+D K+S+
Sbjct: 2292 GIVKEQLAAVTQKWDSLTGQLSD--RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2349

Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNEL 3737
             +  S+   AM +++E        +++ +QQ+ K I+ AQ + + +   +   + K  EL
Sbjct: 2350 SLAVSTHPDAMNQQLETAQK----MKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-EL 2404

Query: 3738 DSEVQDI------VEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC----RTSQLNKA---T 3784
              +++ I      VEQ      + + +      Q+QQ+S+  +     +  + NK+   +
Sbjct: 2405 SRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS 2464

Query: 3785 VKMEEYSDLLKST--------------EAWIENTSHLLANPADYDS------LRTLSHHA 3824
             K++    L+K                E  I    +LL      +       L T+  + 
Sbjct: 2465 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2524

Query: 3825 ST---------------VQMALEDSEQKHNL---LHSIFMDLEDLSIIFETDELTQSIQE 3866
             T               ++ AL+  EQ   L   +     +LE++    +  E   SI +
Sbjct: 2525 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2584

Query: 3867 LSNQVTALQQK--IMESLPQIQRMADDVVAIESEV-----KSMEKRVSKIKTILLSKEI- 3918
            L +    + Q   ++E L         V  I+ EV     KS+ ++V  +   L SK+  
Sbjct: 2585 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 2644

Query: 3919 FDFSPEEHLKHGEVILENIRPMK---------KTIAEIVSYQVELRLPQTGMKPLPVFQR 3969
             +   ++  +  EV  E+ R ++          ++         L + QT  K L   + 
Sbjct: 2645 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 2704

Query: 3970 ----TNQLLQDIKL--------------LENVTQEQNELLKVVIKQTNEWDEEIENLKQI 4011
                  +L QD+ +              +E + QE + L + V ++ +  + +++ +   
Sbjct: 2705 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHF 2764

Query: 4012 LNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQ---ILSLNQRKEDLLVDLKATVLNLH 4068
             N     FS      D+ D +  +  + E ++KQ   I +  ++ E L+           
Sbjct: 2765 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 2824

Query: 4069 QHLKQEQE-----GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESS 4123
              L  E+      G++RD L A++ +   + +R A  R+    G++  L     +++E S
Sbjct: 2825 MMLATEETSPDLVGIKRD-LEALSKQCNKLLDR-AQAREEQVEGTIKRLEEFYSKLKEFS 2882

Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
            +      +KAE   +S   +      ME +       TI Q+          +M ++   
Sbjct: 2883 ILL----QKAEEHEESQGPV-----GMETE-------TINQQL---------NMFKVFQK 2917

Query: 4184 DSLNTEQGPECSLR-------PNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
            + +   QG +  +         +  +  +T  +E D  D +     L  +V +   +  E
Sbjct: 2918 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 2977

Query: 4237 VLHAC-----------KTQVAELELWLQQANVAVEPETLNADMQ-QVLEQQLVGCQAMLT 4284
             L  C              V   EL   Q   + E + + A +Q Q L Q+L+  +    
Sbjct: 2978 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV 3037

Query: 4285 EI----EHKVAFLLETC-KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSE 4339
            E+      K+A   E   K + L          EAL  K +T    LE + ++ Q+ H  
Sbjct: 3038 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-- 3095

Query: 4340 DQHPTILKKSSEPEHQEALQPVN--LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKD 4397
                            E L+P+N  L+ +E  +        Q    ++Q+ + K +E  D
Sbjct: 3096 ----------------ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED-D 3138

Query: 4398 FIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPEN-DVPDSILSPQGQNGDKWQYLH 4456
             I             + +H +       +    SS E+ D+  S L       D  Q  +
Sbjct: 3139 IIN------------HNKHLHQAVSIGQSLKVLSSREDKDMVQSKL-------DFSQVWY 3179

Query: 4457 HELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQ 4516
             E+  K       L +   +  +     V + N+              L ++  + S L 
Sbjct: 3180 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW--------------LNEVHDKLSKLS 3225

Query: 4517 TQENMTEEAYINLDKKLFELFLTLSQCL---SSVEEMLEMPRLYREDGSGQQVHYETLAL 4573
             Q+  TE     L K+  EL +     L    +V++ L       +  +G +V      L
Sbjct: 3226 VQDYSTE----GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL 3281

Query: 4574 E-LKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL 4632
            E +K  Y  ++    D+ K +    +    L    + L   L+  +   +     +  G 
Sbjct: 3282 EAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE 3341

Query: 4633 DYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKL 4692
            + +++ Q   K L  +  K+  +L  SLNE+S   +     +A       E  E  VA  
Sbjct: 3342 EASQA-QMRPKELKKEA-KNNKALLDSLNEVSSALLELVPWRAR------EGLEKMVA-- 3391

Query: 4693 RDEGERLHLPY-ALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELV 4751
             ++ ER  L    + Q+V +++  +       +A   ELS  ++TE+++  +  G + L 
Sbjct: 3392 -EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS--WITETEKKLMSLGDIRLE 3448

Query: 4752 KIGKEKLAHGHLKQTKSKVALQA----QIENHKVFFQKLV-ADMLLIQAYSAKILPSLLQ 4806
            +            QT +++ +Q     +I  HK     LV +   ++ A S +   S+ +
Sbjct: 3449 Q-----------DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3497

Query: 4807 NRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSL 4866
              +       T  +I  E+  Q       + Q WE ++E +  L  + + +IS LP+ +L
Sbjct: 3498 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT-ETQSIISQLPAPAL 3556

Query: 4867 VEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELE-GQIAKLEEQW 4925
              ET  +  E    ++Q++  I      + +    G QL+      EL  G+   ++E++
Sbjct: 3557 EYETLRQQQEE---HRQLRELIAEHKPHIDKMNKTGPQLL------ELSPGEGFSIQEKY 3607

Query: 4926 LS---LNKKIDHELHRLQALLKHLLSYNRD-SDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
            ++   L  +I  ++ +    L   +S +    D++ + LES +  +   + Q  ++S ++
Sbjct: 3608 VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEV 3666

Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLI 5041
            + I+  I+     S ++++   L   +   G +++         + A   Q +      +
Sbjct: 3667 EKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDK------L 3720

Query: 5042 TQLPDIQEKLHQLQMEKLPSRKAITEMIS--WMNNVEHQTSDEDS------VHSPS-SAS 5092
             Q+  I E +H L  E+      + E+    W +++    + +D+      +  P    S
Sbjct: 3721 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 3780

Query: 5093 QVKHLLQKHKEFRMEMDYKQWIVDFV-NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQW 5151
             VK   +  +  R E+D  Q  +D V N     ++ C    K   +    + + E+N  W
Sbjct: 3781 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK----KSIDELNSAW 3836

Query: 5152 HRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              ++     +I  LE+ +++  + ++ +Q + +W++    +L ++    + +   K    
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK---- 3892

Query: 5212 CQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID---------ELFQKRSSVL 5262
             Q IE     KS+A  + +     L   A  LL+      D         EL     S+ 
Sbjct: 3893 -QQIEELKQFKSEAYQQ-QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLE 3950

Query: 5263 TQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQS 5322
             ++   +  ++  L     +    DE+          +   KPV    + +  ++     
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4010

Query: 5323 LQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQ 5381
            LQ++  + + + E + +    L +      A  ++ K +  ++RW  V +    + Q+  
Sbjct: 4011 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4070

Query: 5382 SLLQLWKAYSNAHGEAAARLKQ--QEAKFQQLANISMSG--NNLAEILPPALQDIKELQH 5437
              L+  K +   HGE    L+Q   + +   LA+  + G      E L   ++     + 
Sbjct: 4071 GALRQAKGF---HGE-IEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4126

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL------------QRAAYLEKML 5485
              +  K    +   +L R P+ AE++    +   +++L            +R   LE+ L
Sbjct: 4127 KEETYKSLMQKGQQMLARCPKSAETN----IDQDINNLKEKWESVETKLNERKTKLEEAL 4182

Query: 5486 LVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
             + A EF   L  F ++  + E    +       LD +  Q  E+   F N V +   Q 
Sbjct: 4183 NL-AMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH-KVFANEVNSHREQI 4240

Query: 5546 PDIE----HLNEVSLKLPLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLY 5600
             +++    HL   S K  +  V +K L  ++  +W +     +ER   L       K  +
Sbjct: 4241 IELDKTGTHLKYFSQKQDV--VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFH 4298

Query: 5601 CCEKWIQLLEKIEEALK-----VDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQS 5655
              E W +L+E +EE+ K     +++AN   ++  Q   +K  +  +    ++ D+     
Sbjct: 4299 --EAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4356

Query: 5656 LQLLDTTEI-ENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFR 5714
              L + T + ++  +     S+L D+W        +R+  ++  +     FT +++ L  
Sbjct: 4357 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4416

Query: 5715 FLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQR---RRTTCALTLEAGEKLLLT 5771
            +L      L+     E   ++    L+  L +    FQ+   +RT+    L+   + L+ 
Sbjct: 4417 WLYRVEPQLA-----EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4471

Query: 5772 TDLKTKESVGRRISQLQDSWKDM-------EPQLAEMIKQ---FQSTVETWDQCEKKIKE 5821
                    V  ++ +L   W+ +       + +L   ++Q   F S V    +   +  E
Sbjct: 4472 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE-AE 4530

Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLV 5881
               R   +    ED L  L   +   KE +K+LE+  A     L +  TM   +      
Sbjct: 4531 QTLRFHGVLPDDEDALRTL---IDQHKEFMKKLEEKRA----ELNKATTMGDTVLAICHP 4583

Query: 5882 EDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVL 5941
            + +  +K  I  +  ++E++       +Q +   L   +   E  + L AWL   E  + 
Sbjct: 4584 DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT 4643

Query: 5942 QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAE 5991
                  I + IE++ K  + E   F E ++  KQ     +  + K RAA+
Sbjct: 4644 DKDKEVIPQEIEEV-KALIAEHQTFME-EMTRKQPDVDKVTKTYKRRAAD 4691



 Score =  155 bits (393), Expect = 1e-36
 Identities = 696/3708 (18%), Positives = 1397/3708 (37%), Gaps = 554/3708 (14%)

Query: 616  ETLAQWNLEHATLNEAGNFLVEVSNDVVG--SSISKELRRLNKRWRKLVSKTQLE----- 668
            ++L +   E  +L E     VE + ++    S+ISK L+   K  +   SK ++      
Sbjct: 1097 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1156

Query: 669  ----------MNLPLMIKKQDQPTFDNSGNILSKEEKATVE-----FSTDMSVELPENYN 713
                        + L + K      D   N L K+ K   E     FS  +        +
Sbjct: 1157 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTS 1216

Query: 714  QNIKAGEKHEKENE-EFTGQLKVAKDV-----EKLIGQVEIWEAEAKSVLDQDDVDTSME 767
             ++K  EK   E + E+  +L+   D+      +LIG  E +       ++     +  E
Sbjct: 1217 GDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI-GDGTVELKKYQSKQE 1275

Query: 768  ESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
            E  K +        E++  +E+ L+ + + +S ++         ++ K+ EAK K +   
Sbjct: 1276 ELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL------IEQKLNEAKIKCEQLN 1329

Query: 828  VKLIAALKNLTDV--------SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELIS 879
            +K   + K L  V        +  +    ++EES+ ++E+ +     +    E  G   +
Sbjct: 1330 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG---T 1386

Query: 880  KHKEALIISNTKSLAKYLKAV----EELKNNVTE-DIKMSLEEKSRDVCAKWESLHHELS 934
            KHK+ +  + T       K+     +E+  N+ E D+   +     ++  +++ +  +  
Sbjct: 1387 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1446

Query: 935  LYVQQLKIDIEKGKLSDNILKLEKQ-INKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLN 993
              + Q +  I   + +  +L+ + Q ++ E+K   +   K L   +E   +E     +L 
Sbjct: 1447 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1506

Query: 994  HHMEVLRELCEELPS-QKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEG 1052
            H ++      EEL        E +  L+  EQ++E L   A +I+  +       S +E 
Sbjct: 1507 HSLQ------EELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1560

Query: 1053 TI---------TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESI 1103
             I         T S NR  +       +K D       A    ++  L       +    
Sbjct: 1561 VISHKGDLRYITISGNRVLEAAKSC--SKRDGGKVDTSATHREVQRKLDHATDRFRSLYS 1618

Query: 1104 MEKDYSASINSLLERYDTYRDI---LEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQ 1160
                   ++  L+++Y  Y D    L   LQ  +   +   S         LQ +L + +
Sbjct: 1619 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 1678

Query: 1161 VIKNETDARWKEFEIISLKLENHV----------NDIKKPFVIKERDTLKERERELQMTL 1210
             ++ +  ++    E +    E  +          NDI+K       D +  R  +L  ++
Sbjct: 1679 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTL-----DDIVGRYEDLSKSV 1733

Query: 1211 NTRMESLETALRLVLPVEKA------------SLLLCGSDLPLHKMAIQGFHLIDADRIY 1258
            N R E L+  L   L V+              S L     +PL+  A+Q       D I 
Sbjct: 1734 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ-------DIIS 1786

Query: 1259 QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHR---- 1314
            +++   QD   +Q  I N + E     ++   P    ++Q  +     +F   +H+    
Sbjct: 1787 KNIMLEQDIAGRQSSI-NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 1845

Query: 1315 ----------VQRSEDTLKALEDFLAS----LRTAKLSAEPVTDLSASDTQVAQENTLTV 1360
                      V+  E+  + L+ FL +    L    +  + VT+LS    +   E     
Sbjct: 1846 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 1905

Query: 1361 KNKEGEIHLMKDKAKH---LDKCLKM-----LDMSFKDAE------RGDDTSCENLLDAF 1406
            K+ E    L+K+ + H    DK L +     L   FK+ E      +   TSC+  LDAF
Sbjct: 1906 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 1965

Query: 1407 SIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHR 1466
             + +     +   +E T++  +++   F   +L K+++D +    K  LK P +  V + 
Sbjct: 1966 QVLVKSLKSW--IKETTKKVPIVQPS-FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2022

Query: 1467 KKSLIRLDKVLDEYEEEKRHLQE----------MANSLPHFKDGREKTVNQQCQNTVVLW 1516
              SL  L   +    +    ++             N+   + +    ++ +   +    +
Sbjct: 2023 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2082

Query: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
            E+   L+ + + +    L  L++ Q   S +   +QK     +         + +    +
Sbjct: 2083 EDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQ 2142

Query: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD-RWLDINEKTE 1635
            +E  K    E  + V+K+ ++   L   L +     E P  K+    +D +W ++N+ T 
Sbjct: 2143 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2202

Query: 1636 DYYENLGRALALWDKLFNLKNVIDEW-TEKALQKMELHQLTEEDRERLKEELQVHEQKTS 1694
            D  + L  +     +   ++  + +W  EK L    L  L+  D   L  + Q  +    
Sbjct: 2203 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQ 2261

Query: 1695 EFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDL 1754
            EF+ R  + + L  + +  L     + S+   ++     +T + +  +L+G  ++  + +
Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWD--SLTGQLSDRCDWI 2319

Query: 1755 DQAKTQIGMTESLLKALSP---------SDSLEIFTK--------------LEEIQQQIL 1791
            DQA  +    +SLL++LS          S SL + T                +EIQQ+  
Sbjct: 2320 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2379

Query: 1792 QQKHSMILLENQIGCLTPEL--SELKKQYESVSDLFNTKKSVLQDHFSKL---------L 1840
            Q K +  L E+    +  E   +EL +Q E +   F   +   ++H   L          
Sbjct: 2380 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2439

Query: 1841 NDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL-TLEGRNSKIKQVDSVLK 1899
                ++F  W    K    +    S     +E  ++   DF  TL  ++   ++  +  +
Sbjct: 2440 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2499

Query: 1900 HVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWL 1959
            ++      +    L   L   +   +      + R  +L++SL++ L+ ++    L  W+
Sbjct: 2500 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2559

Query: 1960 T---NQEEKWKGMEEP--GEKTELFCQALARKREQ-FESVAQLNNSL----------KEY 2003
                N  E+ K   +P  GE +    ++L ++ +Q F  V  LNN+           KE 
Sbjct: 2560 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2619

Query: 2004 GFTEEEEIIMEATCLMDRYQTL----------LRQLSEIEEEDK---------------- 2037
               E + +I +   + ++  +            ++  E+ +E K                
Sbjct: 2620 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 2679

Query: 2038 -----------LLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEI 2086
                       +L T+ +S   L H V    K + + L+V          E    K    
Sbjct: 2680 GSQAYSNKYLTMLQTQQKSLQALKHQV-DLAKRLAQDLVV----------EASDSKGTSD 2728

Query: 2087 ILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLL---- 2142
            +LL+ E  A+  + + Q    +   ++  L  I +  +    + S +    ++L      
Sbjct: 2729 VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV 2788

Query: 2143 --EGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLK 2200
              + E   + KE ++  L +L+       AL           K+     + + DL  + +
Sbjct: 2789 GRDAETLQKQKETIKAFLKKLE-------ALMASNDNANKTCKMMLATEETSPDLVGIKR 2841

Query: 2201 ELKS---QGNYLLECTKNPSFSEEPWLEIKHLHE--SLLQQLQDSVQNLDGHVREHDSYQ 2255
            +L++   Q N LL+  +  +  E+    IK L E  S L++    +Q  +    EH+  Q
Sbjct: 2842 DLEALSKQCNKLLD--RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE----EHEESQ 2895

Query: 2256 VCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKS 2315
              V     T++     F  F  + +      E LQ  Q+  N L            L +S
Sbjct: 2896 GPVGMETETINQQLNMFKVFQKEEI------EPLQGKQQDVNWLGQ---------GLIQS 2940

Query: 2316 VKQNTSSVGQKIIKDDIKSL-QCKQKDLENRLASAKQEMECC------LNSILKSKRSTE 2368
              ++TS+ G +   DD+ +  +   K +  R A  ++ +  C      L S+L     TE
Sbjct: 2941 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3000

Query: 2369 KKGKFTLPGREKQATSD---VQESTQESAAVEKLEEDW----EINKDSAVEMAMSKQ--- 2418
            +     L   +K  +++   V+   QE   +++L +D     E+ K    ++A + +   
Sbjct: 3001 E-----LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055

Query: 2419 -LSLNAQESMKNTEDERKVN--ELQNQPLELDTMLR----------NEQLEEIEKLYTQL 2465
             + +  Q S+ ++  E  +N  E +N+ LE  +++           NE L  IEK     
Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3115

Query: 2466 EAKKAAIKPLEQTECLNKTETGALVLHN--------IGYSAQHLDNLLQALITLKKNKES 2517
            E        LE+    +K     ++ HN        IG S + L +     +   K   S
Sbjct: 3116 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3175

Query: 2518 QYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNL 2577
            Q   + + QE   +    ++  L + +      ++ + +L+++   ++ +  +  S   L
Sbjct: 3176 QVWYI-EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3234

Query: 2578 KIKWENLSN-HVTDMDKKLLESQIKQ-LEHGWEQVEQQ-------IQKKYSQQVVEYDEF 2628
               W+  S   V   D  L +  + Q L +G E ++Q        IQ K       Y + 
Sbjct: 3235 ---WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI 3291

Query: 2629 TTLMNKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKG---- 2684
            T L   V  T     +Q   L  RL S  E            +++   +   VLKG    
Sbjct: 3292 TKLSTDVAKT----LEQALQLARRLHSTHEELCTWLD---KVEVELLSYETQVLKGEEAS 3344

Query: 2685 QAELQMKRIWGE-KEKKNLEDGINNLKKQ------WETLEPLH-LEAEN----QIKKCDI 2732
            QA+++ K +  E K  K L D +N +         W   E L  + AE+    ++    I
Sbjct: 3345 QAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3404

Query: 2733 RNKMKET-----------------ILWAKNLLGELNP--SIPLLPDDILSQIRKCKVTHD 2773
              K++E                  + W      +L     I L  D   +Q++  K    
Sbjct: 3405 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3464

Query: 2774 GILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKL 2833
             IL  +  ++ L +     + + +  E   +   L+ +   Y  +   +++R  QLE   
Sbjct: 3465 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3524

Query: 2834 EERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGIST 2893
               + F+    +    + E+++ II ++   A E E      TL   Q+E +++   I+ 
Sbjct: 3525 SLVNQFWETYEELWPWLTETQS-IISQLPAPALEYE------TLRQQQEEHRQLRELIAE 3577

Query: 2894 HLQELTNIYE------ELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQ 2947
            H   +  + +      EL+  E   ++++        ++I+  ++     ++  I    Q
Sbjct: 3578 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 3637

Query: 2948 FHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
            FH+K   + E   S++R    L Q  +  +  E+  +K++++  K   + + KL+ +++ 
Sbjct: 3638 FHDKIDQILE---SLERIVERLRQPPS--ISAEVEKIKEQISENKNVSVDMEKLQPLYET 3692

Query: 3008 I------------GLNWDFS------QLDQL-------QTQVFEKEKELEEKIKQLDTFE 3042
            +            G + D S      +LDQ+        T V E+E +L + ++  + F 
Sbjct: 3693 LKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW 3752

Query: 3043 EEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDE 3100
             +H      +   +    DL+   +   V+K    + E+ R     L + ++    L  E
Sbjct: 3753 CDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSE 3812

Query: 3101 IIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLET 3160
            +I    E    D    +K I ++       D L K  ++ + +L          QD L+ 
Sbjct: 3813 LIAACGEP---DKPIVKKSIDELN---SAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 3866

Query: 3161 SLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC-----EAFQEQVWAEMCSIKAVTAIEKQ 3215
                ++    +L     I  +++ ++ + +       EA+Q+Q+  E  + +A   ++K 
Sbjct: 3867 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 3926

Query: 3216 REENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSL 3275
             EE  S+   V+  L E + +   L   I  R + L  A   L +++ A+   +  +T  
Sbjct: 3927 TEE--SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHT 3984

Query: 3276 EAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMI-------SSPEAKLQ 3328
            E ++   +  VG   +++E+ L K   L++ V   Q   E +          S+ E    
Sbjct: 3985 EGLLSEQK-PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4043

Query: 3329 LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVL--GQSM 3386
            LQ  L+ L  +   + E  + ++ + +  L   K +    ED+   L+  E  L   + +
Sbjct: 4044 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4103

Query: 3387 SSLPLSYREALE-RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSA 3445
              LP + +E L   +E   A  +   + K  + K +Q+L     RC ++    + + ++ 
Sbjct: 4104 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA----RCPKSAETNIDQDINN 4159

Query: 3446 LWEKWLSLLEAAKEWEMWCEELKQ-------------EWKFVSEEI----EREAIILDNL 3488
            L EKW S+     E +   EE                 W   +E+      R ++ILD +
Sbjct: 4160 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4219

Query: 3489 QEELPE--ISKTKEAATTEELSEL------LDCLCQYGENVEKQQLLLTLLLQRIRSIQN 3540
              ++ E  +   +  +  E++ EL      L    Q  + V  + LL+++  +  + +Q 
Sbjct: 4220 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4279

Query: 3541 VPESSGAVETV--------PAFQEITSMKERCNKLLQ---KVQKNKELVQTEIQERHSFT 3589
            + E   +++           A+ ++    E   K L    ++  + + ++T++ +   F 
Sbjct: 4280 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQ 4339

Query: 3590 KEIIALKNFFQQTTTSFQNMAFQ-----DHPEKSEQFEEL--------------QSILKK 3630
            K + A  + +  T  + +++  +     D+ +  +   EL              Q+ L++
Sbjct: 4340 KSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEE 4399

Query: 3631 GKLTFENIMEKLRIKYSEMYTIVPAEIESQVE----ECRKALEDIDEKISNEVLKSSPSY 3686
              L      + L+     +Y + P   E Q      +    L D  +    E+ K + S 
Sbjct: 4400 ALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSV 4459

Query: 3687 -AMRRKIEEINNGLHN----VEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEV 3741
             A++R   E+  G  +    V+  +Q+ S   E    +       L+    +  E  S V
Sbjct: 4460 QALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4519

Query: 3742 QDIVE---------QDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEE--- 3789
              ++E         +  G   +  D L     Q+++  ++ E + ++LNKAT   +    
Sbjct: 4520 HALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLA 4579

Query: 3790 --YSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
              + D + + + WI      +      + L     H   +  AL     K  LL ++   
Sbjct: 4580 ICHPDSITTIKHWI-----TIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAW 4634

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTAL---QQKIMESLPQIQRMADDV 3892
            L+       TD+  + I +   +V AL    Q  ME + + Q   D V
Sbjct: 4635 LQWAETTL-TDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681



 Score =  155 bits (392), Expect = 1e-36
 Identities = 778/4327 (17%), Positives = 1660/4327 (38%), Gaps = 643/4327 (14%)

Query: 2198 LLKELKSQ-GNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQV 2256
            +L  L+S+  ++L +  ++  FS     +++       Q  Q+ +++ +   +E   Y +
Sbjct: 682  VLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNL 741

Query: 2257 CVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSV 2316
             ++++     N      +  D+ + QI    +   L E   R++ Q+   K++  L    
Sbjct: 742  YISEVR----NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL---- 793

Query: 2317 KQNTSSVGQKIIKDDIKSL--QCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFT 2374
                        KDD+ ++  +C++   +   +S+   +   LN +L++           
Sbjct: 794  ------------KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841

Query: 2375 LPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDER 2434
            +   + +  + V ++TQ + A+ KL E     +++ +    + +  ++  +  ++  DE+
Sbjct: 842  ID--KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 899

Query: 2435 KV------NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
            +       +ELQ      D M +  +  +++  +     K+ A + +E+ + ++      
Sbjct: 900  RQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH----KEKADQLVERWQNVHV----- 950

Query: 2489 LVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
                        +DN L+ L  + K+ +          +++  VE++ + +   +E+   
Sbjct: 951  -----------QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI---QENQPE 996

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMD------KKLLESQIKQ 2602
                  T L++ K  ++ IE ++  +   +   E  S  V D +      + +++SQ K 
Sbjct: 997  NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS 1056

Query: 2603 --LEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNK----VQDTEISLQQQQQHLQLRLKSP 2656
                   +     I +++      Y    TLM +      D+   L+++++ L+   K  
Sbjct: 1057 PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH 1116

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
             E+A          +LQ      S     AE   K  +  K+K + E+     ++  E L
Sbjct: 1117 VEKA---------KELQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEAL 1166

Query: 2717 EPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDG 2774
            + + L       K   + RN++++ +         L  S  LL  + L Q+++ + + D 
Sbjct: 1167 QTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLLFSESLKQLQESQTSGD- 1218

Query: 2775 ILARQQSVESLAEEVKDKVPS----LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
            +   ++ V    +E K+K+      LT  E   + +    +     + + K   + ++L+
Sbjct: 1219 VKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1278

Query: 2831 FKLEERSNFFAIIRKF---------QLMVQESETLIIPRVETAATEAELKHHHVTLEASQ 2881
              ++  +   A + K          + + QE + LI    E    EA++K   + L+A Q
Sbjct: 1279 KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI----EQKLNEAKIKCEQLNLKAEQ 1334

Query: 2882 KELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHK 2941
             + +E+D  ++T ++E T         E++    QL+  K +   +  ++ N   + E  
Sbjct: 1335 SK-KELDKVVTTAIKEET---------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERA 1384

Query: 2942 IKFCRQFHEKTSALQEEADSIQR-------NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
                +Q  E+     +E D           N  LL  +V+  V     NL  +   +K  
Sbjct: 1385 GTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1444

Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
              +++   +       +       Q Q    E++++L++ +K+L    E      AL   
Sbjct: 1445 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET-----ALAES 1499

Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEI---IKKLNENKTF 3111
             + + L      E+     D +     L  Q   Q +E  +   D+I   + KL   K+F
Sbjct: 1500 EKKMKLTHSLQEELEKFDADYTEFEHWL--QQSEQELENLEAGADDINGLMTKLKRQKSF 1557

Query: 3112 DDSFKEKEILQIKLNAEENDKLYKVLQ-NMVLELSPK-------ELDEKNCQDKLETSL- 3162
             +           + + + D  Y  +  N VLE +         ++D      +++  L 
Sbjct: 1558 SED----------VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1607

Query: 3163 HVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSE 3222
            H  ++ +S   +  ++   +K + ++  + E     + A + + +A TA +   E  + +
Sbjct: 1608 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEA-TASKHLSEPIAVD 1666

Query: 3223 ASDVETKLREFEDLQMQLNTS------IDLRTNVLNDAYENLTRYKEAVTRAVESITSLE 3276
              +++ +L E + LQ Q+++       +     VL DA  +L   K  + + ++ I    
Sbjct: 1667 PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI---- 1722

Query: 3277 AIIIPYRVDVGNPEESLEMPLRKQEELESTVAH---IQD-LTEKLGMISSPEAKLQLQ-- 3330
                     VG  E+  +    + E+L+ T+     +QD L E L  + + E+ L+ Q  
Sbjct: 1723 ---------VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773

Query: 3331 -----YTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEE-DIYTNLSKMETVLGQ 3384
                   LQ+++SKN  +++    +++      E  K + +  +    ++L      L  
Sbjct: 1774 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 1833

Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND--GICLLKI 3442
              S     ++E L ++E+ K  V    +  E   KL+  L       TE D  G  + ++
Sbjct: 1834 RFSEASHKHKETLAKMEELKTKVELFENLSE---KLQTFLETKTQALTEVDVPGKDVTEL 1890

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIERE-AIILD---NLQEELPEISKT 3498
               + E     LE  K  E+    LK+     S  +  + A++L+   NL ++  E+  T
Sbjct: 1891 SQYMQESTSEFLEHKKHLEVLHSLLKE---ISSHGLPSDKALVLEKTNNLSKKFKEMEDT 1947

Query: 3499 ----KEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
                KEA T+          CQ  E ++  Q+L+  L   I+            + VP  
Sbjct: 1948 IKEKKEAVTS----------CQ--EQLDAFQVLVKSLKSWIKE---------TTKKVPIV 1986

Query: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAF--- 3611
            Q     ++   K L+  +K +E    +  E        I+L N     TT  + +A    
Sbjct: 1987 QPSFGAED-LGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2045

Query: 3612 -------QDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVP---AEIESQV 3661
                   +     +E+F        KG  + +  M  +   Y ++  ++    AE+ +++
Sbjct: 2046 GGAVLNGEGTATNTEEFWA-----NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL 2100

Query: 3662 EECRKALEDID------EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEK 3715
             + +KA E+        +K++    K   + A     E +   +   +    +  +N+ K
Sbjct: 2101 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFEAELKQNVNK 2159

Query: 3716 AQEIQKKMWDELD---------LWHSKLNELDSEVQDIVEQ--DPGQAQEWMDNLMIPFQ 3764
             QE++ K+ + L+          W   L E+DS+ Q++ +   D  Q  E   N +  FQ
Sbjct: 2160 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2219

Query: 3765 ----QYQQVSQRAECRTS--------------QLNKATVKMEEYSDLLKSTEAWIENTSH 3806
                Q +Q     E   S              Q  +  + ++E++      E        
Sbjct: 2220 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2279

Query: 3807 LLANPADYDSLR-------------------TLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
            +L+ P +  SLR                    LS     +  A+  S Q  +LL S+   
Sbjct: 2280 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2339

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQ-------IQRMADDVVAIESEVK 3900
            L DL     +     +  +  NQ     QK+ + + Q        Q + +D+ A+  E  
Sbjct: 2340 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2399

Query: 3901 SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG 3960
               +   +++ IL S +  +   E H++H +    +    ++   +  ++    +  Q  
Sbjct: 2400 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2459

Query: 3961 MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS 4020
              P+            + +LE++ ++  +  K +  Q++ +++ I   + +L        
Sbjct: 2460 SHPISA---------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL-------- 2502

Query: 4021 LEHMSPDQAD---KLPQLQGEIERMEKQILSL-NQRKEDL--LVDLKATVLNLHQHLKQE 4074
            L+    ++A    +L  ++   +   KQ+    N+ KE L   +  K  V  L   + + 
Sbjct: 2503 LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2562

Query: 4075 QEGVERDRLPAVTSE-EGGVAERDASERKL-----------NRRGSMSYLAAVEEEVEES 4122
            Q  +E  +     +E E  +A+  + ++++           N   S+  +  +++EV   
Sbjct: 2563 QNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD 2622

Query: 4123 SVKS-----DNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSM 4177
              KS     D   E+         ++ +  K+ +E   S  S   +Q A  ++   D+  
Sbjct: 2623 ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQE--VSKESKRQLQCAKEQLDIHDSLG 2680

Query: 4178 AQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEAD-TLDSSDAQGGLEP--RVEKTRPEP 4234
            +Q  +   L   Q  + SL+  + +      +  D  +++SD++G  +   +VE    E 
Sbjct: 2681 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 2740

Query: 4235 TEVLHACKTQVAELELWLQQA----NVAVEPETLNADMQ-------------QVLEQQLV 4277
            + +      + + LE  LQ      N   E  +  A+               + L++Q  
Sbjct: 2741 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 2800

Query: 4278 GCQAMLTEIEHKVAF---LLETCK-----DQGLGDNGATQHEAEALSLK----LKTVKCN 4325
              +A L ++E  +A      +TCK     ++   D    + + EALS +    L   +  
Sbjct: 2801 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 2860

Query: 4326 LEKVQ---MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDF 4382
             E+V+     L+E +S+ +  +IL + +E EH+E+  PV + E E+I     Q +  K F
Sbjct: 2861 EEQVEGTIKRLEEFYSKLKEFSILLQKAE-EHEESQGPVGM-ETETI---NQQLNMFKVF 2915

Query: 4383 QQQQVLELKPMEQK-DFIK--FIEFNAKKMWPQYCQHDND-------TTQESSASNQASS 4432
            Q++++  L+  +Q  +++    I+  AK    Q  +HD D       T  +  A   A  
Sbjct: 2916 QKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQL 2975

Query: 4433 PE--------NDVPDSILSPQGQNGDKWQYLHHELSSKIKLP----------------LP 4468
             E         D  +S+LS        W     EL +  K P                L 
Sbjct: 2976 QEALLHCGRFQDALESLLS--------WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3027

Query: 4469 QLVEPQVST-------------------NMGILPSVTMYNFRYPTT-EELKTYTTQLEDL 4508
            +L++ + ST                    + IL  +++ + R+     + +T   QLE +
Sbjct: 3028 RLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI 3087

Query: 4509 RQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHY 4568
               A           E    ++K+L       +Q  S +EE +   +   +D      H 
Sbjct: 3088 SVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKH- 3145

Query: 4569 ETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSL 4628
                     L+ A+S   G  LK ++   E+ +++    D  QV     Q  +  RS+ L
Sbjct: 3146 ---------LHQAVSI--GQSLKVLS-SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3193

Query: 4629 KAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ-SLNEISGQSVAEQLQKADAYTVELENAES 4687
            +  L   + +  +   L + L +    L + S+ + S + + +Q  +      ++   + 
Sbjct: 3194 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3253

Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS--SPFVTESQQDAL-- 4743
             V +    G  L L      EV  ++D L++    ++ARY +++  S  V ++ + AL  
Sbjct: 3254 NVDQALLNGLEL-LKQTTGDEVLIIQDKLEA----IKARYKDITKLSTDVAKTLEQALQL 3308

Query: 4744 ---LQGMVE-----LVKIGKEKLAHGHLKQTKSKVALQAQI---------ENHKVFFQKL 4786
               L    E     L K+  E L++   +  K + A QAQ+         +N+K     L
Sbjct: 3309 ARRLHSTHEELCTWLDKVEVELLSY-ETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3367

Query: 4787 --VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFD 4844
              V+  LL      +++P         W  +    K++ E + +  +   ++ QK EE D
Sbjct: 3368 NEVSSALL------ELVP---------WRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3412

Query: 4845 ENYASLEKDLEILISTLPSVSLVEETEERLV---------ERISFYQQIKRNIGGKHARL 4895
               A++ +  +   +    +S + ETE++L+         ++ S   Q+++    +  R 
Sbjct: 3413 ---AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3469

Query: 4896 YQTLNE----GKQLVASVSCPELEGQIAKLE------EQWLSLNKKIDHELHRLQALLKH 4945
               +++    G +++ + S  E +    KL+      +    +N +   +L R Q+L+  
Sbjct: 3470 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3529

Query: 4946 LLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK 5005
               +    ++L  WL  +Q  ++     +L    + +T+R       +  + + E     
Sbjct: 3530 ---FWETYEELWPWLTETQSIISQLPAPAL----EYETLRQQQEEHRQLRELIAEHKPHI 3582

Query: 5006 TAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAI 5065
              +   G QLL L   +  +++      +  ++ +   +      L +   +       I
Sbjct: 3583 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKI 3642

Query: 5066 TEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQL 5125
             +++  +  +  +     S+ +     ++K  + ++K   ++M+  Q + + + Q   ++
Sbjct: 3643 DQILESLERIVERLRQPPSISA--EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700

Query: 5126 ------STCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKI 5179
                  +  D+ +K  +     + L +M   W  +H ++  +   L  ++E   +     
Sbjct: 3701 IARSGGTDKDISAKAVQ-----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 3755

Query: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
              L   ++  ++ ++ L+ P    SV K     Q+    +  +   L E     + L S 
Sbjct: 3756 MSLIVTIKDTQDFIRDLEDPGIDPSVVK---QQQEAAETIREEIDGLQEELDIVINLGSE 3812

Query: 5240 AVPLLED-----TASRIDELFQKRSSV----LTQVNQLKTSMQSVLQEWKIYDQLYDEVN 5290
             +    +         IDEL     S+      ++++L+ +MQ+ +Q       ++D V+
Sbjct: 3813 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD 3872

Query: 5291 MMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL--KGLC 5348
            +   +    +    P+   LET++ Q+E L+  + EA   +   E+L      L  K   
Sbjct: 3873 IAGGK----LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 3928

Query: 5349 PSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKF 5408
             S    +++        W  + + I ++  K +  L     + +A  E  A L   E   
Sbjct: 3929 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 3988

Query: 5409 QQLANISMSGNNLAEILPPALQDIKELQHDV---QKTKEAFLQNSSVLDRLPQPAESSTH 5465
             +   +   G+  A  +  A   +  LQ+DV   Q T EA  +  + L       E+S  
Sbjct: 3989 SEQKPVG--GDPKAIEIELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN- 4043

Query: 5466 MLLPGPLHSL-QRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---- 5520
              L   L  L QR   + +    +  + +  L Q K F   +E L+  +   E +L    
Sbjct: 4044 --LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASK 4101

Query: 5521 --DRLHQQEKENPDSFLNHVLALTAQSPDIEHL----NEVSLKLPLSDVAV--KTLQNMN 5572
                L +  KE  +  +    A  A+    + L     ++  + P S      + + N+ 
Sbjct: 4102 PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4161

Query: 5573 RQWIRATATALERCSELQ-GIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
             +W        ER ++L+  + L  +F    + +I  L + E+ L V    S P L+   
Sbjct: 4162 EKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA---SRPSLILDT 4218

Query: 5632 KTYKMLEAEVSINQTIADSYVTQSLQLLDT-TEIE--NRPEFITEFSKLT----DRWQNA 5684
              +++ E +V  N+   +S+  Q ++L  T T ++  ++ + +     L      RW+  
Sbjct: 4219 VLFQIDEHKVFANEV--NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV 4276

Query: 5685 VQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-SAVKGQERFSLYQTRSLIHE 5743
            VQ + +R   +D   ++ + F  +   L  +L ++   L S ++        +T+   H+
Sbjct: 4277 VQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4336

Query: 5744 LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE-SVGRRISQLQDSWKDMEPQLAEMI 5802
               K +    + +    T   G  L   T L      +   +S+L+D W  +  +  E  
Sbjct: 4337 EFQKSLG--AKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394

Query: 5803 KQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELI---KELEQSLA 5859
             + +  +    Q    ++ L   L  ++ Q  +  P +H D+     LI   K  ++ L 
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-VHGDIDLVMNLIDNHKAFQKELG 4453

Query: 5860 SWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTW 5919
              T +++ L+    +L      +D   +K Q++ L  +WE +C     ++  +E  L   
Sbjct: 4454 KRTSSVQALKRSARELIEGSR-DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4512

Query: 5920 VVFNEKNKELCAWLVQMENK-----VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
              F+     L  WL + E       VL   + ++  +I++  K+ M+++        +  
Sbjct: 4513 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ-HKEFMKKLEEKRAELNKAT 4571

Query: 5975 QMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNL 6034
             MGD ++   +      I   +  I  R++ +        ++L    A +    + +  L
Sbjct: 4572 TMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEAL 4631

Query: 6035 RTWLARIESELS---KPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
              WL   E+ L+   K V+    + +E++  +AE Q    ++ +    V+ V        
Sbjct: 4632 LAWLQWAETTLTDKDKEVIPQ--EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRA 4689

Query: 6092 HDSDAC-------------------------ANETECDSIQQTTRSLDRRWRNICAMSME 6126
             D  +                           ++T+ ++       L  +W+ +  +++E
Sbjct: 4690 ADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALE 4749

Query: 6127 RRMKIEE 6133
            RR K+ +
Sbjct: 4750 RRRKLND 4756



 Score =  146 bits (369), Expect = 6e-34
 Identities = 583/3325 (17%), Positives = 1279/3325 (38%), Gaps = 552/3325 (16%)

Query: 1077 PSTEKAMEPTMKFSLASVLRPLQEESI-----MEKDYSASINSLLERYDTYRDILE-HHL 1130
            P+  +AM P++ F++     P  +E++     +E+ Y   +    E +   + ++  H+L
Sbjct: 601  PTGNEAMVPSVCFTVP----PPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYL 656

Query: 1131 QNNKFRI-TSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIIS----LKLENHVN 1185
             N   RI  S+ +S +       Q  L++LQ    +     +E ++ S     +LE  VN
Sbjct: 657  INEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVN 716

Query: 1186 DIKKPFVIKERDTLKERERELQ------------MTLNTRMESLETAL--RLVLPVEKAS 1231
              K+ +    ++ LK  ERE Q              +  R+E+ E  L  ++  P+E+  
Sbjct: 717  VCKQYY----QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 772

Query: 1232 LLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHP 1291
            L         H+     F + + +++ + L  ++D +     I N+ EE  +        
Sbjct: 773  L---------HESV---FRITEQEKLKKELERLKDDLGT---ITNKCEEFFSQAAASSSV 817

Query: 1292 FDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASDT 1350
              L +  N++L+   Q   M+       D LK +   L + + A+   +   T L   + 
Sbjct: 818  PTLRSELNVVLQNMNQVYSMSSTYI---DKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874

Query: 1351 QVAQENTL-----TVKNKEGEI-------HLMKD---KAKHLD----KCLKMLDMSFKDA 1391
             +A +N +     T+K    E+       H ++D   KAK +     K  K  D+ F   
Sbjct: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934

Query: 1392 ERGDDTSCE---NLLDAFSIKLSETHGYGVQEEFTEEN-KLLEACIFKNNELLKNIQDVQ 1447
            +   D   E   N+      +L +  G G   ++  +    L+  I +     + IQ+ Q
Sbjct: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994

Query: 1448 SQISKIGLKDPTVPAVKHRKKSLI-RLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
             + SK      T+    +++K L+  ++    + +E +++ ++ + ++   KD   +T+ 
Sbjct: 995  PENSK------TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV---KDYELQTMT 1045

Query: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
             +     ++    K+ V     Q    L +++++ + ++  T L+      +  Q     
Sbjct: 1046 YRA----MVDSQQKSPVKRRRMQSSADL-IIQEFMDLRTRYTALV-----TLMTQYIKFA 1095

Query: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
             ++LK+   E + ++EE  EH+E   ++ +   N+   L   +   +PPF K+       
Sbjct: 1096 GDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK------ 1149

Query: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
                +E+     E L  AL            I  +  K   KM     T+E+R  L++++
Sbjct: 1150 --ISSEEISTKKEQLSEAL----------QTIQLFLAKHGDKM-----TDEERNELEKQV 1192

Query: 1687 Q-VHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME----------SSILNKMEHVQKCLT 1735
            + + E     FS  + ++Q    S ++ +E +++             I + +   +  L 
Sbjct: 1193 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1252

Query: 1736 GESNCHALSGSTAELR----EDLDQAKTQIGMTESLLKALSPSDSL--EIFTKLEEIQQQ 1789
            G      +   T EL+    +  +  K   G  ++L + +  +++   E   KL +  + 
Sbjct: 1253 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1312

Query: 1790 ILQQKHSMILLENQIGC--LTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCK-- 1845
            +++QK    L E +I C  L  +  + KK+ + V      +++       +L   + K  
Sbjct: 1313 LIEQK----LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE 1368

Query: 1846 NFNDWFSNIKVNLKEC--------------FESSETKKSVEQKLQKLSDFL--------- 1882
            N  DW SN+  + +                F+  + K ++ ++ +   + L         
Sbjct: 1369 NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG 1428

Query: 1883 -TLEGRNSKIKQV----DSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKE 1937
             T E  N + ++V    + ++   +  +      +++    GQ    E+ E + Q   KE
Sbjct: 1429 TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL-QKNMKE 1487

Query: 1938 LE-----------------DSLQQLLRLQD-DHRNLRKWLTNQEEKWKGMEEPGEKTELF 1979
            L+                  SLQ+ L   D D+     WL   E++ + +E   +     
Sbjct: 1488 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1547

Query: 1980 CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATC---------------------- 2017
               L R++   E V      L+    +    +    +C                      
Sbjct: 1548 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1607

Query: 2018 -LMDRYQTLLRQLSEIEEEDKLLPTEDQSFND-----------------------LAHDV 2053
               DR+++L  + + +    K L  + Q + D                       +A D 
Sbjct: 1608 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 1667

Query: 2054 IHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQ 2113
             +  ++++E+  +      +    E+++K  E++L     DAR   +  + +      +Q
Sbjct: 1668 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-----DARGSLLPAKND------IQ 1716

Query: 2114 KTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLML-----IELKKKQEAG 2168
            KTL DI  ++++   L+ +     EKL +   + L  ++ L  ML     +E   K++  
Sbjct: 1717 KTLDDIVGRYED---LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773

Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH 2228
              L        A   I  K +   QD+       +S  N + E  K    + +P      
Sbjct: 1774 VPL-----NSTALQDIISKNIMLEQDIAG----RQSSINAMNEKVKKFMETTDP-----S 1819

Query: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTL---DNFSKEFVSFSDKPVDQIA- 2284
               SL  +++D          +H      + +L T +   +N S++  +F +     +  
Sbjct: 1820 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 1879

Query: 2285 -------VEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQC 2337
                   V E  Q +QE  +        L+ + +L K +  +     + ++ +   +L  
Sbjct: 1880 VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK 1939

Query: 2338 KQKDLENRLASAKQEMECC------LNSILKSKRSTEKKGKFTLP-GREKQATSDVQEST 2390
            K K++E+ +   K+ +  C         ++KS +S  K+    +P  +      D+ +S 
Sbjct: 1940 KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSL 1999

Query: 2391 QESAAVEKLEEDW-----EINK------------------DSAVEMAMSKQLSLNAQESM 2427
            +++   +KL+E W     EI K                    A+    S    LN + + 
Sbjct: 2000 EDT---KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2056

Query: 2428 KNTED----------ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ 2477
             NTE+          ++ + ++ +   +L  +L+++  E   KL    +A++ +   ++ 
Sbjct: 2057 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2116

Query: 2478 TECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCVLRDFQEYLAAVESSM 2536
             + +NKT T         +         +A+ T +++NK               + E+ +
Sbjct: 2117 LQKMNKTAT--------KWQQTPAPTDTEAVKTQVEQNK---------------SFEAEL 2153

Query: 2537 KALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLL 2596
            K  +   + LK    D +T L +         + K  L  +  KW+ L+    D  +KL 
Sbjct: 2154 KQNVNKVQELK----DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2209

Query: 2597 ESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKSP 2656
            ES     +       Q ++ +  Q +VE +   +++  +      L  Q+Q +Q+ L+  
Sbjct: 2210 ESSNNLTQF------QTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEF 2263

Query: 2657 EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL 2716
              R             Q T  G  +L    E           +  +++ +  + ++W++L
Sbjct: 2264 ATRKPQYE--------QLTAAGQGILSRPGE-------DPSLRGIVKEQLAAVTQKWDSL 2308

Query: 2717 EPLHLEAENQIKKCDIRNKMKETILWA-----KNLLGELNPSIPLL--PDDILSQIRKCK 2769
                 +  + I +  +++   +++L +      +L  +L+ S+ +   PD +  Q+   +
Sbjct: 2309 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2368

Query: 2770 VTHDGILARQQSV---ESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRS 2826
                 I   ++ +   ++L E++   V     Y  ++L+  LE +   ++ +  K+    
Sbjct: 2369 KMKQEIQQEKKQIKVAQALCEDLSALVKE--EYLKAELSRQLEGILKSFKDVEQKAENHV 2426

Query: 2827 QQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVT-----LEASQ 2881
            Q L+        F  + R FQ  +   +            E + K H ++     LE+  
Sbjct: 2427 QHLQSACASSHQFQQMSRDFQAWLDTKK------------EEQNKSHPISAKLDVLESLI 2474

Query: 2882 KELQEIDSGIS--THLQELT-----NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNT 2934
            K+ ++    ++  +H+ E T     N+  +    E+  L+ QL  +K   +   + ++  
Sbjct: 2475 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2534

Query: 2935 CNEVEHKIKFCRQFHEKTSALQEEADSIQRN--ELLLNQEVNKGVK------------EE 2980
             N+++  ++   ++ E+   L    D  Q N  E+    +  +G              ++
Sbjct: 2535 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2594

Query: 2981 IYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDT 3040
             + + + L      +L V ++ K            ++D +  Q+  K+  LE   ++   
Sbjct: 2595 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKE 2654

Query: 3041 FEE--EHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLC 3098
            F+E  +  K Q   +K   +D+     ++       +  ++++ + Q L  +++ AK L 
Sbjct: 2655 FQEVSKESKRQLQCAK-EQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 2713

Query: 3099 DEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKL 3158
             +++ + +++K   D      +LQ++  A+E+  L + +      L  K     + Q+ +
Sbjct: 2714 QDLVVEASDSKGTSD-----VLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 2768

Query: 3159 ETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREE 3218
                    +   +L     +  + + +Q +K+  +AF +++ A M S        K    
Sbjct: 2769 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 2828

Query: 3219 NSSEASDVETKLREFEDLQMQLNTSIDL----------RTNVLNDAYENLTRYKEAVTRA 3268
                + D+    R+ E L  Q N  +D               L + Y  L  +   + +A
Sbjct: 2829 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 2888

Query: 3269 VESITSLEAIIIPYRVDVGNPEESLEM-PLRKQEELESTVAHIQDLT-EKLGMISSPEAK 3326
             E   S      P  ++     + L M  + ++EE+E      QD+     G+I S    
Sbjct: 2889 EEHEESQG----PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKS 2944

Query: 3327 LQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKM----ETVL 3382
               Q    +L   N+  K   K     A +  E      + ++ + + LS M    E V 
Sbjct: 2945 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3004

Query: 3383 GQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKI 3442
             Q   S    ++    ++++ K L   L   K  +  +++    +       D + +LK 
Sbjct: 3005 NQKPPS--AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3062

Query: 3443 VSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP--EISKTKE 3500
            +S L  +W +LL  A+      E +    +   E +E     L  +++ L   E   T+ 
Sbjct: 3063 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3122

Query: 3501 AATTEELSE---LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEI 3557
            +   E++++   L D +  + +++ +      + + +   + +  E    V++   F ++
Sbjct: 3123 SKLEEQIAQHKALEDDIINHNKHLHQ-----AVSIGQSLKVLSSREDKDMVQSKLDFSQV 3177

Query: 3558 TSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEK 3617
              +     ++ +K     EL+Q  +     F ++ + L N+  +       ++ QD+  +
Sbjct: 3178 WYI-----EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3232

Query: 3618 S--EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAE---IESQVEECRKALEDID 3672
               +Q  EL+ + +   L  +N+ + L      +      E   I+ ++E  +   +DI 
Sbjct: 3233 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDI- 3291

Query: 3673 EKISNEVLKS-SPSYAMRRKI----EEINNGLHNVEKMLQQ------KSKNIEKAQEIQK 3721
             K+S +V K+   +  + R++    EE+   L  VE  L        K +   +AQ   K
Sbjct: 3292 TKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK 3351

Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMI-PFQQYQQVSQRAECRTSQL 3780
            ++  E     + L+ L+     ++E  P +A+E ++ ++    ++Y+ VS     +  ++
Sbjct: 3352 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3411

Query: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL 3840
            + A ++ +++     +  +WI  T   L +  D      L    ++ Q+ ++ +     L
Sbjct: 3412 DAAILRSQQFDQAADAELSWITETEKKLMSLGDI----RLEQDQTSAQLQVQKTFTMEIL 3467

Query: 3841 LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQ-QKIMESLPQIQRMADDVVAIESE- 3898
             H   +           D+L +S  ++    +  + Q + + L ++ +  D +  I SE 
Sbjct: 3468 RHKDII-----------DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3516

Query: 3899 ------------------------VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVIL 3934
                                    +   +  +S++    L  E      EEH +  E+I 
Sbjct: 3517 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3576

Query: 3935 E---NIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELL 3991
            E   +I  M KT  +++        P  G      +   + L   IK  E+V +++   L
Sbjct: 3577 EHKPHIDKMNKTGPQLLELS-----PGEGFSIQEKYVAADTLYSQIK--EDV-KKRAVAL 3628

Query: 3992 KVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQ 4051
               I Q+ ++ ++I+ + +         SLE +  ++  + P +  E+E++++QI     
Sbjct: 3629 DEAISQSTQFHDKIDQILE---------SLERI-VERLRQPPSISAEVEKIKEQI----S 3674

Query: 4052 RKEDLLVDLKATVLNLHQHLKQEQE 4076
              +++ VD++  +  L++ LKQ  E
Sbjct: 3675 ENKNVSVDME-KLQPLYETLKQRGE 3698



 Score = 88.6 bits (218), Expect = 2e-16
 Identities = 194/1107 (17%), Positives = 435/1107 (39%), Gaps = 123/1107 (11%)

Query: 1408 IKLSETHGYGVQEEFTEENKL--------------LEACIFKNNELLKNIQDVQSQISKI 1453
            ++LS   G+ +QE++   + L              L+  I ++ +    I  +   + +I
Sbjct: 3593 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3652

Query: 1454 GLK---DPTVPA--------VKHRKKSLIRLDKVLDEYEEEKRHLQEM-ANSLPHFKDGR 1501
              +    P++ A        +   K   + ++K+   YE  K+  +EM A S    KD  
Sbjct: 3653 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 3712

Query: 1502 EKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQ-NFKSILTTLIQKEESVISL 1560
             K V  +    V +WEN   LV E   +   V+EL +++  +  S++ T+   ++ +  L
Sbjct: 3713 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 3772

Query: 1561 QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA 1620
            +   +    +K++    E ++EE +   E +D +  +   L   +      ++P  +K  
Sbjct: 3773 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL---IAACGEPDKPIVKKSI 3829

Query: 1621 NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE 1680
            + +   W  +N+  +D  + L  A+    +  +    + +W + A  K+        D E
Sbjct: 3830 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 3889

Query: 1681 RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMES------SILNKMEHVQKCL 1734
             +K++++  +Q  SE  ++  E++ L   +E+ L+    ES        L +++ +   L
Sbjct: 3890 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 3949

Query: 1735 TGE--SNCHALSG---STAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQ 1789
                 +  H L G   +  + +  LD+    +  TE LL    P        ++E  +  
Sbjct: 3950 EERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH 4009

Query: 1790 ILQ-------------QKHSMILLENQIG----CLTPELSELKKQYESVSDLFNTKKSVL 1832
            +LQ              K    L+E+  G     L  +L  L +++++V +    +K  L
Sbjct: 4010 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4069

Query: 1833 QDHF--SKLLNDQCKNFNDWFSNIKVNL---KECFESSETKKSVEQKLQKLSDFLTLEGR 1887
                  +K  + + ++   W ++ + +L   K      ET K  EQ    +      E +
Sbjct: 4070 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK 4127

Query: 1888 NSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLR 1947
                K +    + +    PK+    +   +   + + E +E+    R  +LE++L   + 
Sbjct: 4128 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4187

Query: 1948 LQDDHRNLRKWLTNQEEKWKGMEEPG----------EKTELFCQALARKREQFESVAQLN 1997
              +  ++   WLT  E+       P           ++ ++F   +   REQ   + +  
Sbjct: 4188 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4247

Query: 1998 NSLKEYGFTEEEEIIMEATCLM---DRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVI 2054
              LK   F++++++++    L+    R++ ++++L E            + F++    ++
Sbjct: 4248 THLKY--FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM 4305

Query: 2055 HWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARI---ETIMKQAESSEAPL 2111
             W++E ++SL      + ++ +     KIK  +    E    +    ++      +   L
Sbjct: 4306 EWLEESEKSL------DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359

Query: 2112 VQKT------------LTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLI 2159
             +KT            L+++ ++WD     +    +  E+ LL   ++  + + L   L 
Sbjct: 4360 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4419

Query: 2160 ELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK-NPSF 2218
             ++ +      +   +      +  +K F K+    TS ++ LK     L+E ++ + S+
Sbjct: 4420 RVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSW 4479

Query: 2219 SEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDK 2278
             +    E+    E++          L+  +R+ + +   V  L   L    +        
Sbjct: 4480 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4539

Query: 2279 PVDQIAVEEKLQKLQELENRLSLQDGTLKK-------ILALAKSVKQNTSSVGQKIIKDD 2331
            P D+ A+   + + +E   +L  +   L K       +LA+       T      II+  
Sbjct: 4540 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4599

Query: 2332 IKSLQCKQKDLENRLAS------AKQE-MECCLNSILKSKRSTEKKGKFTLPGREKQATS 2384
             + +    K  + RLAS      AKQE +E  L  +  ++ +   K K  +P   ++  +
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4659

Query: 2385 DV-------QESTQESAAVEKLEEDWE 2404
             +       +E T++   V+K+ + ++
Sbjct: 4660 LIAEHQTFMEEMTRKQPDVDKVTKTYK 4686



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 46/228 (20%), Positives = 106/228 (46%), Gaps = 9/228 (3%)

Query: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            D+W+ I  + +  + K+++ L    Q    + A+  WL + E +L   +      DI  +
Sbjct: 4381 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4438

Query: 6590 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 6649
               +   +   K      + V ++  S++E ++    +S+ ++ ++++LS  WE      
Sbjct: 4439 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4498

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRRELMQ 6708
             S +  L  +L Q ++FH +   LL WLA A+   R    + D +   R L++  +E M 
Sbjct: 4499 ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM- 4557

Query: 6709 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 6756
              K+L E++ +++    + +++L   H +     +  + +I  + +++
Sbjct: 4558 --KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4603



 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 13/234 (5%)

Query: 6548 KIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6604
            K+++ +Q   Q    + A+  W+     +L    M+   +D++ ++ +++ L++      
Sbjct: 3849 KLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA--SMSPIGTDLETVKQQIEELKQFKSEAY 3906

Query: 6605 TYKALVVSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQ 6662
              +  +  +N  ++  L+  TE  +   +Q  L +L L+W++ +  + + +  L  +L+ 
Sbjct: 3907 QQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 3966

Query: 6663 CQDFHQLSQNLLLWLASAKN--RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV 6720
               F      LL WL   +     QK    DPKA    L +       L+ +++  Q  V
Sbjct: 3967 LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHH----VLQNDVLAHQSTV 4022

Query: 6721 DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 6774
            + + +  N L+    GE+    + K+ V+ ++ + + E+  Q    L G    A
Sbjct: 4023 EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4076



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 56/276 (20%), Positives = 107/276 (38%), Gaps = 24/276 (8%)

Query: 6504 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 6550
            K G  VLNG     N ++   + GL  I +  +     +E +      +  EL+ KL   
Sbjct: 2044 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2101

Query: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 6610
              LQ+   + SA+  WL+K        +    P+D + ++ +V++ +            V
Sbjct: 2102 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2160

Query: 6611 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
              +     E L+   ++PE+   +  L ++   W+         +  L +S      F  
Sbjct: 2161 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2220

Query: 6669 LSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKELVERQPQVDMLQEIS 6727
            +   L  WL     +     V  P   DP  L   R+++  L +E   R+PQ + L    
Sbjct: 2221 VEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2277

Query: 6728 NSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 6761
              +L +   +  +    +E++  + +K   L  Q+S
Sbjct: 2278 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2313



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 100/456 (21%), Positives = 179/456 (39%), Gaps = 90/456 (19%)

Query: 585  LACWATYVENLRL-LRACFEETKKEEIKEVPFETLAQWNLEHAT----LNEAGNFLVEVS 639
            L  W T+ E L    +    + K  EI+      L    L H +    +N+AGN L+E S
Sbjct: 3977 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4036

Query: 640  NDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVE 699
                 S++  +L  LN+RW+ ++ KT+         +KQ           L    +    
Sbjct: 4037 AGEEASNLQNKLEVLNQRWQNVLEKTEQ--------RKQQ----------LDGALRQAKG 4078

Query: 700  FSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEA-EAKSVLD 758
            F  ++     E+  Q +   E+H   ++   G  + AK  E+L   +E+  A EAK    
Sbjct: 4079 FHGEI-----EDLQQWLTDTERHLLASKPLGGLPETAK--EQLNVHMEVCAAFEAK---- 4127

Query: 759  QDDVDTSMEESLKHLIAKG-SMFDELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQ 817
                    EE+ K L+ KG  M       +E  +  DI N+  +E ++ V     + K+ 
Sbjct: 4128 --------EETYKSLMQKGQQMLARCPKSAETNIDQDINNL--KEKWESV-----ETKLN 4172

Query: 818  EAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGEL 877
            E K K++                   L++ ++   S ++  +++ +A+Q L     P  +
Sbjct: 4173 ERKTKLE-----------------EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4215

Query: 878  -------ISKHKEAL--IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES 928
                   I +HK     + S+ + + +  K    LK    +   + ++     V ++WE 
Sbjct: 4216 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEK 4275

Query: 929  LHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKE-KKLIR--RGRTKGLIKEHEACFSE 985
            +       VQ+L   +E+G+  D+  K  KQ ++   KL+       K L  E E     
Sbjct: 4276 V-------VQRL---VERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4325

Query: 986  EGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKD 1021
            +    QL  H E  + L  +     +     R LK+
Sbjct: 4326 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4361



 Score = 43.9 bits (102), Expect = 0.006
 Identities = 51/245 (20%), Positives = 96/245 (39%), Gaps = 15/245 (6%)

Query: 6541 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 6600
            Q L +        QQ++ D  A   WL   + E           D+  +E  +K  ++  
Sbjct: 2427 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2481

Query: 6601 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6658
            K   T ++ +    ++  E   L+T+  E   LQ +L  +   W+     V      L++
Sbjct: 2482 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2540

Query: 6659 SLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQP 6718
            SL +   + +  + L  W+   +N  ++        DP        +L  L+KE+ +   
Sbjct: 2541 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFC---LDPAEGENSIAKLKSLQKEMDQHFG 2597

Query: 6719 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLP 6778
             V++L   +NSLL     +  +  +E   +I+ K+  + EQ+      L   +N      
Sbjct: 2598 MVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCL---ENMTQKFK 2653

Query: 6779 SFDEV 6783
             F EV
Sbjct: 2654 EFQEV 2658



 Score = 41.6 bits (96), Expect = 0.028
 Identities = 49/249 (19%), Positives = 105/249 (42%), Gaps = 31/249 (12%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
            W+ ++ + ++ + K++  L    Q    +  +  WL  TE    +L   KP   D + IE
Sbjct: 3946 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG---LLSEQKPVGGDPKAIE 4002

Query: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
            + + +   +      +++ V +VN +  + +++ +  E++ LQ++L  L+  W+      
Sbjct: 4003 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4062

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
            +  +  L  +L Q + FH   ++L  WL   +      H+   K     L E  +E + +
Sbjct: 4063 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER-----HLLASK-PLGGLPETAKEQLNV 4116

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGH--------------GEDCIEAEEKVHVIEKKLKQ 6755
              E+       +  +E   SL+ KG                +D    +EK   +E KL +
Sbjct: 4117 HMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4173

Query: 6756 LREQVSQDL 6764
             + ++ + L
Sbjct: 4174 RKTKLEEAL 4182



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 17/259 (6%)

Query: 6554 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR--LQEILKAFDTYKALVV 6611
            QQ +    A  +W+ +TE +L  L   +   D    +L+V++    EIL+  D    LV 
Sbjct: 3419 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3478

Query: 6612 SVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQ 6671
            S     K        E   ++ +L ++   ++            L ++      F +  +
Sbjct: 3479 S---GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3535

Query: 6672 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
             L  WL   ++    + +  P  +   L + + E  QL + + E +P +D + +    LL
Sbjct: 3536 ELWPWLTETQS--IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3593

Query: 6732 IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMAL-----QGTQ---NPASPLPSFDE- 6782
                GE     +EK    +    Q++E V +  +AL     Q TQ        L S +  
Sbjct: 3594 ELSPGEG-FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3652

Query: 6783 VDSGDQPPATSVPAPRAKQ 6801
            V+   QPP+ S    + K+
Sbjct: 3653 VERLRQPPSISAEVEKIKE 3671



 Score = 37.0 bits (84), Expect = 0.68
 Identities = 46/248 (18%), Positives = 99/248 (39%), Gaps = 20/248 (8%)

Query: 6535 WEMIQAQELHNKLKIKQ----NLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD---IQ 6587
            W +   ++ H++ ++ Q    N +    D   +  WL +   +L  L +    ++    Q
Sbjct: 3178 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3237

Query: 6588 EIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQG 6647
            + ELRV +   +L+  +  +AL+  + +      QT   E   +Q +L  +   ++    
Sbjct: 3238 QSELRVLQEDILLRKQNVDQALLNGLELLK----QTTGDEVLIIQDKLEAIKARYKDITK 3293

Query: 6648 AVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELM 6707
                    L Q+L   +  H   + L  WL   +           K +  +  + R +  
Sbjct: 3294 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-- 3351

Query: 6708 QLEKELVERQPQVDMLQEISNSLL-------IKGHGEDCIEAEEKVHVIEKKLKQLREQV 6760
            +L+KE    +  +D L E+S++LL        +G  +   E  E+  ++   + Q  E++
Sbjct: 3352 ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEI 3411

Query: 6761 SQDLMALQ 6768
               ++  Q
Sbjct: 3412 DAAILRSQ 3419



 Score = 36.2 bits (82), Expect = 1.2
 Identities = 42/181 (23%), Positives = 81/181 (44%), Gaps = 25/181 (13%)

Query: 310  KEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREA 369
            K+++++L K  +++ Y ++       ME  N + +  L  ++ + D   +    ++L+  
Sbjct: 3892 KQQIEEL-KQFKSEAYQQQIE-----MERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 3945

Query: 370  WDGLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL- 422
            WD L+ +I   + KL  AL         L +  AWL   E L+ E      D  +A+ + 
Sbjct: 3946 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD-PKAIEIE 4004

Query: 423  ------IQEKMTLFKSLMDRFEHHSNILLTFENKDE-NHLPLVPPNKLEEMKRRINNILE 475
                  +Q  +   +S ++      N L+     +E ++L     NKLE + +R  N+LE
Sbjct: 4005 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ----NKLEVLNQRWQNVLE 4060

Query: 476  K 476
            K
Sbjct: 4061 K 4061



 Score = 35.8 bits (81), Expect = 1.5
 Identities = 33/191 (17%), Positives = 88/191 (46%), Gaps = 18/191 (9%)

Query: 6549 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 6605
            + QNL  +++N   +  +  W+ + + +L+  +     SD+  +E  ++  + + +A + 
Sbjct: 268  LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 324

Query: 6606 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQD 6665
            +++ +    +S    +Q  +P       +L +L    E+    + +      + L    +
Sbjct: 325  FESSLKEAKISE---IQMTAPLKLTYAEKLHRL----ESQYAKLLNTSRNQERHLDTLHN 377

Query: 6666 FHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLEKELVERQPQVDMLQ 6724
            F   + N L+WL    N +++  V    ++    +  +++   +L +EL +++  +  +Q
Sbjct: 378  FVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQ 433

Query: 6725 EISNSLLIKGH 6735
            EI+  LL++ H
Sbjct: 434  EIAEQLLLENH 444



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 24/146 (16%), Positives = 64/146 (43%), Gaps = 2/146 (1%)

Query: 6624 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6683
            +S  +  L+  L  ++  W+     V      L+++L+ C  F    ++LL W+   +  
Sbjct: 2943 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-- 3000

Query: 6684 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6743
               A+   P A+ + +    +E   L++ L +R+  V++++     +       D ++  
Sbjct: 3001 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3060

Query: 6744 EKVHVIEKKLKQLREQVSQDLMALQG 6769
            +++ +++ + + L  +       L+G
Sbjct: 3061 KQLSLLDSRWEALLNKAETRNRQLEG 3086


>gi|19923599 calmin [Homo sapiens]
          Length = 1002

 Score =  224 bits (570), Expect = 3e-57
 Identities = 128/272 (47%), Positives = 173/272 (63%), Gaps = 7/272 (2%)

Query: 18  IDDLHI-SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSG 76
           I D+ + +LQ E+E+ QK+ FT WIN  L +   P  + DLF DI+ G +L+ LLEVLSG
Sbjct: 18  ISDIRVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSG 77

Query: 77  QQLPRDKGSNTFQC-RIN-IEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILH 134
           + L  +  S++ +  R+N I  AL FL + ++KL++I   +I DGNPS++LGLIW IIL 
Sbjct: 78  RNLLHEYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILF 137

Query: 135 FHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPP---AKKCSKVQARWQMSARKALLLWA 191
           F I++L   LS N    SL   S    S +S PP   A++   +  + Q  A KALL W 
Sbjct: 138 FQIKELTGNLSRNSPSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWV 197

Query: 192 QEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQ 251
           Q +   Y  V V DF  SWR+G+AFLA+I A+ P L+DMK     S ++NL +AF IA+ 
Sbjct: 198 QRKTRKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQD 256

Query: 252 ELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQ 283
            L IPRLLEPED+ V  PDE+SIMTYVAQFL+
Sbjct: 257 ALHIPRLLEPEDIMVDTPDEQSIMTYVAQFLE 288


>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score =  223 bits (568), Expect = 5e-57
 Identities = 586/3068 (19%), Positives = 1192/3068 (38%), Gaps = 510/3068 (16%)

Query: 1    MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD 60
            MA   E     + G     D+  S   E  D QKK FT WIN++ ++   P  I+D+FTD
Sbjct: 1    MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPP-INDMFTD 59

Query: 61   IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN 120
            +K G  LLDLLE L+G  LP+++GS       N+   L  L   +++L+NI  TDI+DGN
Sbjct: 60   LKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGN 119

Query: 121  PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ 180
              + LGL+W+IILH+ ++ + + +  +                                Q
Sbjct: 120  HKLTLGLLWSIILHWQVKDVMKDVMSDLQ------------------------------Q 149

Query: 181  MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
             ++ K LL W ++    Y  VNV +F +SW +G+AF A++H  +PDL     V   S  +
Sbjct: 150  TNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIE 209

Query: 241  NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQ----------------- 283
             L  AF  A+  L I +LL+PEDV V  PD+KSI+ Y+    +                 
Sbjct: 210  RLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETL 269

Query: 284  ---YSK-----------------------DAPGTGEEA-------QGKVKDAMGWLTLQK 310
               Y K                       + P T  E        Q  +++ + WL   +
Sbjct: 270  PRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAE 329

Query: 311  EKLQKLLKDSENDTYFK-KYNSLLSFMESFNEEKKSFLDVLSIKRDL-----------DE 358
            +  Q+    S++    K ++ +  +FM      + S   VL     L            E
Sbjct: 330  DTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFE 389

Query: 359  LDKDHLQLREAWDGLDHQINAWKIKLNYAL----PPPLHQTEAWLQEVEEL--------M 406
            + +    L   W+ L  +    + +L+  L       L Q  AWL   EE         +
Sbjct: 390  IQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPL 449

Query: 407  DEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEM 466
            D+D+ + Q   +    +Q  +   +  ++   H   +++  EN  E+   ++  ++L+++
Sbjct: 450  DDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH--MVVIVDENSGESATAIL-EDQLQKL 506

Query: 467  KRRIN----------NILEKKFILLLEFHYYKCLV---LGLVDEVKSKLDIWNIKYGSRE 513
              R            N L++  IL  E    +CL+   L   +E  +K+   N K     
Sbjct: 507  GERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKEL 566

Query: 514  SVE-----LLLEDWHKFIEEKEFLARLDTSFQKCGEIYKN-LAGECQNINKQYMMVKSDV 567
            SV      +L ED      +++ L +L    Q  G++  N  A +  N + + +  + D 
Sbjct: 567  SVSVRRLAILKEDMEM---KRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDS 623

Query: 568  CMYR-----KNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWN 622
             + R       +    + L          +E +R+      +  K+E+   P     Q +
Sbjct: 624  LVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIH 683

Query: 623  LEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQ-- 680
            ++     +      E+ N ++    + +   + K + K+   ++++  L  + K+Q +  
Sbjct: 684  VDIEAKKKFDAISAELLNWILKWKTAIQTTEI-KEYMKMQDTSEMKKKLKALEKEQRERI 742

Query: 681  ---PTFDNSGNIL----SKEEKATVEFSTDMSVELPE--NYNQNIKAGEKHEKENEEFTG 731
                  + +G IL     KE   T E    +     E  N +Q+++  E+  +  E+   
Sbjct: 743  PRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINA 802

Query: 732  QLKVAKDVEKLIGQVEIW-------EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELM 784
              K   ++EK+I   E W       E+  +S+    D   S +  L +L+      +   
Sbjct: 803  YFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKD---SCQRELTNLLGLHPKIEMAR 859

Query: 785  ARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVK---------LIAALK 835
            A    ++         Q  F   L  G    +QEA E  Q ++            +  LK
Sbjct: 860  ASCSALMSQPSAPDFVQRGFDSFL--GRYQAVQEAVEDRQQHLENELKGQPGHAYLETLK 917

Query: 836  NLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAK 895
             L DV  D + + ++      + + + + ++ L ++++  E++   K AL       LA+
Sbjct: 918  TLKDVLNDSENKAQV---SLNVLNDLAKVEKALQEKKTLDEILENQKPAL-----HKLAE 969

Query: 896  YLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQL-KIDIEKGKLSDNIL 954
              KA+E+   NV  D++   +++  DV  KW  L   +S  +  L +I +       +  
Sbjct: 970  ETKALEK---NVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADST 1026

Query: 955  KLEKQINKEKKLIRR-----GRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEEL--- 1006
             +EK ++  K  + +     G   GL ++ + C +    +  +   ++ ++E+   L   
Sbjct: 1027 VIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSG 1086

Query: 1007 PSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHS 1066
            P    +  V+  L DY+ ++E+L K                      I T ++R  +   
Sbjct: 1087 PVAGIKTWVQTRLGDYQTQLEKLSK---------------------EIATQKSRLSESQE 1125

Query: 1067 EAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYS----ASINSLLERYDTY 1122
            +A   K D     E   +               EE  +E+D+       + S +E     
Sbjct: 1126 KAANLKKDLAEMQEWMTQ--------------AEEEYLERDFEYKSPEELESAVEEMKRA 1171

Query: 1123 R-DILEHH-----LQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEF-EI 1175
            + D+L+       L++N   + +   S     +S L   L + Q++ N    +     E+
Sbjct: 1172 KEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEV 1231

Query: 1176 ISLKLE-NHVNDIKKPFVIKERDTLKERERELQM------TLNTRMESLETALRLVLPVE 1228
             S  +E  H  D++  ++    +TL+ER +  ++       +N  +ESLE+ LR   P +
Sbjct: 1232 WSCWIELLHYLDLETTWL----NTLEERMKSTEVLPEKTDAVNEALESLESVLR--HPAD 1285

Query: 1229 KASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICN-RLEEPGNFVLK 1287
              +           ++   G  LID          + D I++++E  N R E+  +  L 
Sbjct: 1286 NRT-----------QIRELGQTLIDGG-------ILDDIISEKLEAFNSRYEDLSH--LA 1325

Query: 1288 ELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSA 1347
            E     L     ++ +        +  +Q  +++L  L+  L +  T ++ A        
Sbjct: 1326 ESKQISLEKQLQVLRE-------TDQMLQVLQESLGELDKQLTTYLTDRIDA-------- 1370

Query: 1348 SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFS 1407
               QV QE     +  + EI   +   + L + ++   ++  ++      S    +D   
Sbjct: 1371 --FQVPQE----AQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGS---QMDVLQ 1421

Query: 1408 IKLSE--THGYGVQEEFTEENKLLEACIFKNNELLKNIQD-VQSQISKIGLKDPTVPAVK 1464
             KL E  T     Q+    E ++L+          K + D V++++  + +KD     ++
Sbjct: 1422 RKLREVSTKFQLFQKPANFEQRMLDC---------KRVLDGVKAELHVLDVKDVDPDVIQ 1472

Query: 1465 HRKKSLIRLDKVLDEYE-EEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523
                  ++L K L E + E +  ++   + +   +    K +++Q  +  VL+ +  A V
Sbjct: 1473 THLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQV 1532

Query: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG-KENLKKRIAEIEIVKE 1582
            TE  +   R  +L ++ +   + L+  +   E+ +  +++  G   +L   I+  + V +
Sbjct: 1533 TEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLK 1592

Query: 1583 EFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG 1642
            +  +    ++ I +    LQ  +       EP  E+   ++   W  +   TED+   L 
Sbjct: 1593 DLEKRKADLNTITESSAALQNLIEG----SEPILEERLCVLNAGWSRVRTWTEDWCNTL- 1647

Query: 1643 RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE 1702
                                                          H+ +   F   VA 
Sbjct: 1648 --------------------------------------------MNHQNQLEIFDGNVAH 1663

Query: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG 1762
            I   L  +E  L+   +E    +K E + K L  E     L  +  ++    DQA   + 
Sbjct: 1664 ISTWLYQAEALLD--EIEKKPTSKQEEIVKRLVSE-----LDDANLQVENVRDQALILMN 1716

Query: 1763 MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCL-TPELSELKKQYESV 1821
               S  + L      E+    E++ Q I   K  +I  E    CL T E  E    +  +
Sbjct: 1717 ARGSSSRELVEPKLAELNRNFEKVSQHIKSAK-LLIAQEPLYQCLVTTETFETGVPFSDL 1775

Query: 1822 SDLFNTKKSVL---QDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878
              L N  +++L   + H     +D+ +  ++  + I+  L+   E         +K +  
Sbjct: 1776 EKLENDIENMLKFVEKHLES--SDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIR 1833

Query: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF--ELEKMESICQARAK 1936
               L L  R +KIK +      +++         + S L+  ++  E+ K+  +C     
Sbjct: 1834 LQLLLLHTRYNKIKAIP-----IQQRKMGQLASGIRSSLLPTDYLVEINKI-LLCM---- 1883

Query: 1937 ELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQL 1996
               D ++  L + + +  + +  + QE+  K +++  +K       +  K+         
Sbjct: 1884 ---DDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQP-------- 1932

Query: 1997 NNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHW 2056
             + + E    E  +I    T L  ++  + R  S+ +        E + F+   +D+  W
Sbjct: 1933 -DVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQW 1991

Query: 2057 IKEIKESLMVLNSSEGKMPLEE-RI--QKIKEIILLKPEGDARI----ETIMKQAESSEA 2109
            I E +E L+   +  G + LE+ RI  Q+++  I       A +    + I+++   ++ 
Sbjct: 1992 ITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADG 2051

Query: 2110 PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ---- 2165
              +++ L  ++ +WD    + +     Q +L  E ++ ++ +  L  ++  L K +    
Sbjct: 2052 SFLKEKLAGLNQRWD---AIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108

Query: 2166 -----EAGFALQHGLQEKKAQLKIYKKFLK------------------KAQDLTSLLKEL 2202
                 E G  LQ  L++   +++++ + LK                  +   ++  L+ +
Sbjct: 2109 KRSTTELGENLQE-LRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTV 2167

Query: 2203 KSQGN--------YLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSY 2254
                N         L EC + PS   +  +     H ++ + +  S  + D  V+ H + 
Sbjct: 2168 NMTWNKICREVPTTLKECIQEPSSVSQTRIA---AHPNVQKVVLVSSAS-DIPVQSHRTS 2223

Query: 2255 QVCV-TDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKK----- 2308
            ++ +  DL+ T+   +   V         I     ++++ +  +R+ +    L++     
Sbjct: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283

Query: 2309 --ILALAKSVKQNTSSVGQK-IIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKR 2365
              +  LA+++K   SS   +  I + ++ ++ +    ++ +   +Q++E   + I+ S +
Sbjct: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLE---DMIIDSLQ 2340

Query: 2366 STEKKGKFTLPGREKQATSDVQESTQESAAVEKLEED----WEINKDSAVEMAMSKQLSL 2421
              + + +     R+ +A   + +  +     +++ ++     E+     + MA    L  
Sbjct: 2341 WDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQK 2400

Query: 2422 NAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQ-TEC 2480
              +E    ++D R V E           L+    +    L  +    +A+ + LE   + 
Sbjct: 2401 LLEE--YGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKW 2458

Query: 2481 LNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALL 2540
            + + ET      N+   A H +N LQ  I  ++ K+     ++D Q  + A     K++ 
Sbjct: 2459 IQEAETTV----NVLVDASHRENALQDSILARELKQQ----MQDIQAEIDAHNDIFKSID 2510

Query: 2541 TDKESL--KVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKK---- 2594
             +++ +   +G  +  T L         ++       +LK K  ++  H+    +K    
Sbjct: 2511 GNRQKMVKALGNSEEATMLQH------RLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564

Query: 2595 --LLESQIKQLEHGWEQVEQQ--IQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ 2650
               LE  IK L    E++++Q  I        ++YD    L  ++++ E S+       +
Sbjct: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624

Query: 2651 LRL-----KSPEE-RAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLED 2704
            + L     ++PEE R   QS   LT + +A K   ++ K  +E++ K  W         +
Sbjct: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEK--W---------E 2673

Query: 2705 GINNLKKQWETLEPLHLEAENQIKKC--DIRNKMKETILWAKNLLGELNPSIPLLPDDIL 2762
             +N +   W+      LE    ++    D+   MKE    A+++     P   LL D + 
Sbjct: 2674 SLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE----AESVRNGWKPVGDLLIDSLQ 2729

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
              I K     + I      V+++  ++  ++  L  +    ++  L+DL  ++++L +  
Sbjct: 2730 DHIEKIMAFREEIAPINFKVKTV-NDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSV 2788

Query: 2823 TQRSQQLE 2830
              R +QL+
Sbjct: 2789 DDRLKQLQ 2796



 Score =  125 bits (315), Expect = 1e-27
 Identities = 482/2660 (18%), Positives = 993/2660 (37%), Gaps = 458/2660 (17%)

Query: 3772 RAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLAN----PADYD--SLRTLSHHAS 3825
            R E    Q     V ME     L+   AW+  T   +      P D D  SL+ L     
Sbjct: 405  RVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHK 464

Query: 3826 TVQMALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQI 3885
            ++Q  LE  + K N L  + + +++ S    T  L   +Q+L  + TA+ +   E   ++
Sbjct: 465  SLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL 524

Query: 3886 QR-------MADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHL----KHGEVIL 3934
            Q        + ++   +++ +   E+ ++K++T        +F  ++ L    +   ++ 
Sbjct: 525  QEINILWQELLEEQCLLKAWLTEKEEALNKVQTS-------NFKDQKELSVSVRRLAILK 577

Query: 3935 ENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVV 3994
            E++   ++T+ ++                  + Q   QLL + K  + +  +  EL    
Sbjct: 578  EDMEMKRQTLDQLSE----------------IGQDVGQLLDNSKASKKINSDSEEL---- 617

Query: 3995 IKQTNEWDEEIENLKQILNNYSAQFSLEHMSP----DQADKLPQLQGEIERMEKQILSLN 4050
               T  WD  ++ L+   N  +   +   MS     D  + +   +  I +  KQ L   
Sbjct: 618  ---TQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPP 674

Query: 4051 Q--RKEDLLVDLKAT---------VLN-------------LHQHLKQEQEGVERDRLPAV 4086
               +K  + VD++A          +LN             + +++K +     + +L A+
Sbjct: 675  PPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKAL 734

Query: 4087 TSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKH 4146
              E+    ER     +LN+ G +     + E++ +  + ++      E     W ++ +H
Sbjct: 735  EKEQ---RERIPRADELNQTGQI-----LVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQH 786

Query: 4147 DKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLN----TEQGPECSLRPNQTE 4202
             +D+E                 KI   ++  A     D L     T++        +++ 
Sbjct: 787  LEDLER----------------KIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESS 830

Query: 4203 EGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLH---ACKTQVAELELWL---QQAN 4256
              + P ++           GL P++E  R   + ++    A        + +L   Q   
Sbjct: 831  RQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQ 890

Query: 4257 VAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALS 4316
             AVE      D QQ LE +L G      +  H     L+T KD         Q     L+
Sbjct: 891  EAVE------DRQQHLENELKG------QPGHAYLETLKTLKDVLNDSENKAQVSLNVLN 938

Query: 4317 LKLKTVKCNLEKVQMMLQEKHS-----EDQHPTILKKSSEPEHQEALQPVNLSELESIVT 4371
                    +L KV+  LQEK +     E+Q P + K + E +  E     ++ +L     
Sbjct: 939  --------DLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKL----- 985

Query: 4372 ERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQAS 4431
                + ++ D  Q +  +LK +  KD     E                T +   A +   
Sbjct: 986  ----YKQEFDDVQGKWNKLKVLVSKDLHLLEEIAL-------------TLRAFEADSTVI 1028

Query: 4432 SPEND-VPDSILSPQGQNGDKWQYLHHELSS---------KIKLPLPQLVEPQVSTNMGI 4481
                D V D ++  Q   GD    L  +L            I+  L  + E + +   G 
Sbjct: 1029 EKWMDGVKDFLMKQQAAQGDD-AGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGP 1087

Query: 4482 LPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS 4541
            +  +  +         L  Y TQLE L +E +  +++ + ++E   NL K L E+   ++
Sbjct: 1088 VAGIKTW-----VQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMT 1142

Query: 4542 QCLSS-------------VEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588
            Q                 +E  +E  +  +ED   ++V  + L   +K L   +     +
Sbjct: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQE 1202

Query: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648
            L   +    EN  LL          LE   +  +     L   LD   ++ N ++    +
Sbjct: 1203 LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWI----ELLHYLDLETTWLNTLE----E 1254

Query: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708
             +KS   L +               K DA    LE+ ES +    D   ++      L +
Sbjct: 1255 RMKSTEVLPE---------------KTDAVNEALESLESVLRHPADNRTQIRELGQTLID 1299

Query: 4709 VYKLEDVLDSMWGMLRARYTELS----SPFVTESQQDALLQGMVELVKIGKEKLAHGHLK 4764
               L+D++        +RY +LS    S  ++  +Q  +L+   +++++ +E L     +
Sbjct: 1300 GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQ 1359

Query: 4765 QTKSKV----ALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVK 4820
             T        A Q   E  K+  + + A  L ++     +    L + E+  A   +++ 
Sbjct: 1360 LTTYLTDRIDAFQVPQEAQKIQAE-ISAHELTLEELRRNMRSQPLTSPESRTARGGSQMD 1418

Query: 4821 ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
            +L+ K R+   K Q L QK   F++     ++ L+ + + L  + + +   + +   +  
Sbjct: 1419 VLQRKLREVSTKFQ-LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDK 1477

Query: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEG---QIAKLEEQWLSLNKKIDHELH 4937
              ++ + +      +   +  G+ +V        +G   Q+  L+  +  L  ++     
Sbjct: 1478 CMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQ 1537

Query: 4938 RLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKE 4997
             L+   +      +++  L++WL +++  L   K  S  +  DLDT  S   N     K+
Sbjct: 1538 DLERASQLARKMKKEAASLSEWLSATETEL-VQKSTSEGLLGDLDTEISWAKNVL---KD 1593

Query: 4998 VDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL--HQLQ 5055
            ++++ +    +      L +L E     L   L      W+ + T   D    L  HQ Q
Sbjct: 1594 LEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQ 1653

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
            +E       +  + +W+   E    + +   +      VK L+        E+D     V
Sbjct: 1654 LEIFDGN--VAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVS-------ELDDANLQV 1704

Query: 5116 DFVNQSLLQLSTCDVESKRYERTEFAE-HLGEMNRQWHRVHGMLNRKIQHLEQLLESITE 5174
            + V    L L      S R    E  E  L E+NR + +V        QH++     I +
Sbjct: 1705 ENVRDQALILMNARGSSSR----ELVEPKLAELNRNFEKVS-------QHIKSAKLLIAQ 1753

Query: 5175 SENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYL 5234
                        E   + L T +  E+ +    L     DIEN L    K L+   +   
Sbjct: 1754 ------------EPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEK 1801

Query: 5235 TLESGAVPLLEDTASRIDELFQ------KRSSVLTQVNQLKTSMQSV----LQEWKIYDQ 5284
              E  A   +E+   R +E+        K+  +  Q+  L T    +    +Q+ K+  Q
Sbjct: 1802 MDEESAQ--IEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKM-GQ 1858

Query: 5285 LYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV----------ENLQSLQDEAESSEGSW 5334
            L   +    +   Y +E +K ++L ++ +   +          E+    +D  ++ +   
Sbjct: 1859 LASGIRSSLLPTDYLVEINK-ILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQL 1917

Query: 5335 EKLQEVIGKLKGLCPSV--------AEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL 5386
            +KL E I  +    P V        A  I +     + +W ++N+  +D+       ++ 
Sbjct: 1918 DKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEE 1977

Query: 5387 WKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF 5446
            W+ +     +    + + E   + L +    G +L                D++K +   
Sbjct: 1978 WRQFHCDLNDLTQWITEAE---ELLVDTCAPGGSL----------------DLEKAR-IH 2017

Query: 5447 LQNSSVLDRLPQPAESSTHMLLPGPLHSLQRA--AYLEKMLLVKANEFEFVLSQFKDFGV 5504
             Q   V     QP+ ++ +    G +  L +A  ++L++ L      ++ ++++ KD   
Sbjct: 2018 QQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQP 2077

Query: 5505 RLESLKGLIMHEEENLDRL--------HQQEKENPDSFLNHVLALTAQSPDIEHLNEVSL 5556
            RL+     +M     LD +        H  +K +           T    +++ L +++ 
Sbjct: 2078 RLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRST----------TELGENLQELRDLTQ 2127

Query: 5557 KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEAL 5616
            ++   +V  + L+ +NR       T LE  S+ + + L E+            +KI E+L
Sbjct: 2128 EM---EVHAEKLKWLNR-------TELEMLSD-KSLSLPER------------DKISESL 2164

Query: 5617 KV------DVANSLPELLEQQKTYKMLEAEVSINQT--IADSYVTQSLQLLDTTEIENRP 5668
            +        +   +P  L++      ++   S++QT   A   V + + +   ++I  + 
Sbjct: 2165 RTVNMTWNKICREVPTTLKE-----CIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQS 2219

Query: 5669 EFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKG 5728
               +E S                  D+D  + +  D+   ++ + +     S++++    
Sbjct: 2220 HRTSEISI---------------PADLDKTITELADWLVLIDQMLK-----SNIVTVGDV 2259

Query: 5729 QERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL---LLTTDLKTKESVGRRIS 5785
            +E          +  +K  +   ++R           + L     ++D++T  ++  ++ 
Sbjct: 2260 EE------INKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRT--AITEKLE 2311

Query: 5786 QLQDSWKDME-------PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLP 5838
            ++++ W   +        QL +MI       +  ++ E+ +++ ++RL +L+    DPL 
Sbjct: 2312 RVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLT 2371

Query: 5839 ELHEDLHNEKELIKELEQS----LASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHL 5894
            +    + + + L++EL       +A      K L+   +D TR+V        KE  E+L
Sbjct: 2372 K---QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNV--------KETTEYL 2420

Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEE---- 5950
               W +L   +A R+  +E    T        +    W+ + E  V    D S  E    
Sbjct: 2421 KTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQ 2480

Query: 5951 ------MIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA-SNKSRAAEIDDKLNKINDRW 6003
                   +++  +D   EI+  ++    +     +++KA  N   A  +  +L+ +N RW
Sbjct: 2481 DSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRW 2540

Query: 6004 QHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK--PVVYDVCDDQEIQK 6061
              L     S    L+ +     +L  ++  L  WL   + EL K  P+  DV     +Q 
Sbjct: 2541 NDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDV---PALQL 2597

Query: 6062 RLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTR-SLDRRWRNI 6120
            +    + L+R++++    V +  +   V L D    A E    ++Q  T  + + R + I
Sbjct: 2598 QYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKI 2657

Query: 6121 CAMSMERRMKIEETWRL-------WQKFLD-------DYSRFEDWLKSAERTAACPNS-- 6164
                 ++  +++E W         WQK +D       D     D L +  + A    +  
Sbjct: 2658 AKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGW 2717

Query: 6165 ---SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
                ++L  S ++ +++  AF+ +I     +++ +N    +L+  +    + ++ + + +
Sbjct: 2718 KPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLD-LHPSLKMSRQLDD 2776

Query: 6222 GNQRWDNLQRRVTAVLRRLR 6241
             N RW  LQ  V   L++L+
Sbjct: 2777 LNMRWKLLQVSVDDRLKQLQ 2796



 Score =  125 bits (314), Expect = 1e-27
 Identities = 301/1561 (19%), Positives = 609/1561 (39%), Gaps = 209/1561 (13%)

Query: 4894 RLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDS 4953
            R Y+   E + +    + PE E +  + E    S   ++D +L   Q  L+ +L+     
Sbjct: 271  RKYKKECEEEAINIQSTAPEEEHESPRAETP--STVTEVDMDLDSYQIALEEVLT----- 323

Query: 4954 DQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGN 5013
                 WL S++ T   ++EQ  ++S D++ ++        F  E+    S   +V+  GN
Sbjct: 324  -----WLLSAEDT---FQEQD-DISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGN 374

Query: 5014 QLLH---LKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
            QL+    L + +   ++  +     +W  L  +  D Q +LH + ME    +K + ++ +
Sbjct: 375  QLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMEL--QKKQLQQLSA 432

Query: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
            W+   E +    ++         ++ LL++HK  + +++ +Q  V+ +   ++ +     
Sbjct: 433  WLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSG 492

Query: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
            ES      +  + LGE   +W  V      +   L+++     E   +  +L  WL  +E
Sbjct: 493  ESATAILEDQLQKLGE---RWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549

Query: 5191 ERLKTLQ------KPESVISVQKLLLDCQDIENQLAIKSKALDELKQ-----SYLTLESG 5239
            E L  +Q      + E  +SV++L +  +D+E    +K + LD+L +       L   S 
Sbjct: 550  EALNKVQTSNFKDQKELSVSVRRLAILKEDME----MKRQTLDQLSEIGQDVGQLLDNSK 605

Query: 5240 AVPLL----EDTASRIDELFQKRSSVLTQVNQLKTSM-------QSVLQEWKIYDQLYDE 5288
            A   +    E+   R D L Q+      QV Q    +       + +L+  ++ +Q   +
Sbjct: 606  ASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITK 665

Query: 5289 VNMMTI---------RFWYCMEHSKPV-VLSLETLRCQVENLQSLQDEAESSEGSWEKLQ 5338
             +   +         +    +E  K    +S E L   ++   ++Q          +   
Sbjct: 666  KSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTS 725

Query: 5339 EVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQK----AQSLLQLWKAYSNAH 5394
            E+  KLK L     E I    +       Q  Q + +Q+ K     + +  + +  S+  
Sbjct: 726  EMKKKLKALEKEQRERIPRADE-----LNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEW 780

Query: 5395 GEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLD 5454
               +  L+  E K Q   +I+     L E+              V KTKE +++++S+ +
Sbjct: 781  KNVSQHLEDLERKIQLQEDINAYFKQLDEL------------EKVIKTKEEWVKHTSISE 828

Query: 5455 R----LPQPAESS----THMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL 5506
                 LP   +S     T++L   P   + RA+     L+ + +  +FV   F  F  R 
Sbjct: 829  SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASC--SALMSQPSAPDFVQRGFDSFLGRY 886

Query: 5507 ESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVK 5566
            ++++  +   +++L+  ++ + +   ++L  +  L     D E+  +VSL + L+D+A  
Sbjct: 887  QAVQEAVEDRQQHLE--NELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNV-LNDLA-- 941

Query: 5567 TLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPE 5626
                           AL+    L  I  N+K           L K+ E  K    N  P+
Sbjct: 942  -----------KVEKALQEKKTLDEILENQK---------PALHKLAEETKALEKNVHPD 981

Query: 5627 LLEQQKTYKMLEAEVSINQTIADSYVTQSLQLL------------DTTEIENRPEFITEF 5674
            +   +K YK    +V          V++ L LL            D+T IE   + + +F
Sbjct: 982  V---EKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDF 1038

Query: 5675 SKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT-SHLLSAVKG--QER 5731
                   Q    G++++       V + +   +S++N+    T+  S  ++ +K   Q R
Sbjct: 1039 LMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTR 1098

Query: 5732 FSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSW 5791
               YQT+    E  +KEI  Q+ R + +    A  K  L    +          +    +
Sbjct: 1099 LGDYQTQL---EKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEY 1155

Query: 5792 KDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ----SEDPLPELHEDLHNE 5847
            K  E +L   +++ +   E   Q E ++K LK  +++L A+     ++   EL+  L N 
Sbjct: 1156 KSPE-ELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENY 1214

Query: 5848 KELIKE-------LEQSLASWTQNLKELQTMKADL--------TRHVLVEDVMVLKEQIE 5892
            + L          LE+  + W + L  L      L        +  VL E    + E +E
Sbjct: 1215 QLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALE 1274

Query: 5893 HLHRQWEDLCLRVAIRKQEIEDRLNTWV--------------VFNEKNKELCAWLVQMEN 5938
             L    E +    A  + +I +   T +               FN + ++L       + 
Sbjct: 1275 SL----ESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQI 1330

Query: 5939 KVLQTADI--SIEEMIEKLQKDCME---EINLFSENKLQLKQMGDQLIKASNKSRAAEID 5993
             + +   +    ++M++ LQ+   E   ++  +  +++   Q+  +  K   +  A E+ 
Sbjct: 1331 SLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELT 1390

Query: 5994 DKLNKINDRWQHL-------------FDVIGSRVKKLKETFAFIQQ---LDKNMSNLRTW 6037
             +  + N R Q L              DV+  +++++   F   Q+    ++ M + +  
Sbjct: 1391 LEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRV 1450

Query: 6038 LARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDAC 6097
            L  +++EL    V DV D   IQ  L +   L + + +    VE+V      ++      
Sbjct: 1451 LDGVKAELHVLDVKDV-DPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQT- 1508

Query: 6098 ANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER 6157
                    + +   SL   + ++ A   E +  +E   +L +K   + +   +WL + E 
Sbjct: 1509 ---DNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATET 1565

Query: 6158 TAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR-LK 6216
                 ++SE L      E+   +   + + +R   L  I +    L  +N  + +   L+
Sbjct: 1566 ELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL--QNLIEGSEPILE 1623

Query: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE 6276
            + +   N  W  ++         L +  NQ E F+G    I  WL + +  L  +E    
Sbjct: 1624 ERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPT 1683

Query: 6277 SDADDKMRQLNGFQQEITLNTNKI-DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
            S  ++ +++L     +  L    + DQ ++    L+         L+E +L EL+R  ++
Sbjct: 1684 SKQEEIVKRLVSELDDANLQVENVRDQALI----LMNARGSSSRELVEPKLAELNRNFEK 1739

Query: 6336 V 6336
            V
Sbjct: 1740 V 1740



 Score =  110 bits (274), Expect = 6e-23
 Identities = 361/1938 (18%), Positives = 753/1938 (38%), Gaps = 270/1938 (13%)

Query: 4482 LPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS 4541
            LP+  + N     + E K  +  LEDL ++   +Q QE++   AY    K+L EL     
Sbjct: 764  LPTEEIKNVLEKVSSEWKNVSQHLEDLERK---IQLQEDIN--AYF---KQLDEL----E 811

Query: 4542 QCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDK----KGDLLKAMTWPG 4597
            + + + EE ++   +            ++   EL  L L L  K    +      M+ P 
Sbjct: 812  KVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNL-LGLHPKIEMARASCSALMSQPS 870

Query: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL--DYNRSYQNEIKRLYHQLIKSKTS 4655
               + +   FD+     +  Q A   R + L+  L      +Y   +K L   L  S+  
Sbjct: 871  A-PDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENK 929

Query: 4656 LQQSLNEISGQSVAEQ-LQKADAYTVELENAESRVAKLRDEGERLHLP-YALLQEVYKLE 4713
             Q SLN ++  +  E+ LQ+       LEN +  + KL +E + L    +  ++++YK E
Sbjct: 930  AQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQE 989

Query: 4714 -DVLDSMWGMLRARYT-------ELSSPFVTESQQDALLQGMVELVK--IGKEKLAHG-- 4761
             D +   W  L+   +       E++           +++  ++ VK  + K++ A G  
Sbjct: 990  FDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDD 1049

Query: 4762 -----HLKQTKSKV----ALQAQIENHKVFFQKLVADMLL-IQAYSAKILPSLLQNRETF 4811
                  L Q  + V     +++ ++N K     L +  +  I+ +    L       E  
Sbjct: 1050 AGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKL 1109

Query: 4812 WAEQVTEVKILEEKSRQCGMKLQSL--LQKW-EEFDENYASLEKDLEILISTLPSVSLVE 4868
              E  T+   L E   +     + L  +Q+W  + +E Y  LE+D E   S     S VE
Sbjct: 1110 SKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEY--LERDFEYK-SPEELESAVE 1166

Query: 4869 E---TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS---------CPELEG 4916
            E    +E ++++    + +K NI    A++    + G++L + ++         C  + G
Sbjct: 1167 EMKRAKEDVLQKEVRVKILKDNIKLLAAKVP---SGGQELTSELNVVLENYQLLCNRIRG 1223

Query: 4917 QIAKLEEQW---LSLNKKIDHE---LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
            +   LEE W   + L   +D E   L+ L+  +K        +D + + LES +  L + 
Sbjct: 1224 KCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHP 1283

Query: 4971 KEQSLNVSQ---------DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKET 5021
             +    + +          LD I S     F  S+  D     ++  IS+  QL  L+ET
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDDIISEKLEAFN-SRYEDLSHLAESKQISLEKQLQVLRET 1342

Query: 5022 DTA--TLRASLAQFEQKWTMLIT------QLPDIQEKL------HQLQMEKLPSRKAITE 5067
            D     L+ SL + +++ T  +T      Q+P   +K+      H+L +E+L        
Sbjct: 1343 DQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQP 1402

Query: 5068 MISWMNNVEHQTSDEDSVHSPSSASQVK-HLLQKHKEFRMEMDYKQWIVDFVNQSLLQLS 5126
            + S  +      S  D +         K  L QK   F   M   + ++D V   L  L 
Sbjct: 1403 LTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLD 1462

Query: 5127 TCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWL 5186
              DV+    +      HL +  +        L + +  ++  +E++ ++   I       
Sbjct: 1463 VKDVDPDVIQT-----HLDKCMK--------LYKTLSEVKLEVETVIKTGRHI------- 1502

Query: 5187 EAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLED 5246
              Q+++    +  +  ++  K+L +  D+  Q+    + L+   Q    ++  A  L E 
Sbjct: 1503 -VQKQQTDNPKGMDEQLTSLKVLYN--DLGAQVTEGKQDLERASQLARKMKKEAASLSEW 1559

Query: 5247 TASRIDELFQKRSS--VLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK 5304
             ++   EL QK +S  +L  ++   +  ++VL++ +      + +   +      +E S+
Sbjct: 1560 LSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSE 1619

Query: 5305 PVVLSLETLRCQVENLQSLQDEAESSEGSW-EKLQEVIGKLKGLCPSVAEIIEEKCQNTH 5363
            P+   LE   C    L +      +    W   L     +L+    +VA I         
Sbjct: 1620 PI---LEERLCV---LNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHI--------- 1664

Query: 5364 KRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAE 5423
              W    +A+ D+++K  +  Q             A L+ +  + Q L  ++  G++  E
Sbjct: 1665 STWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRE 1724

Query: 5424 ILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
            ++ P L ++                     +++ Q  +S+  ++   PL+          
Sbjct: 1725 LVEPKLAELNRN-----------------FEKVSQHIKSAKLLIAQEPLYQC-------- 1759

Query: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTA 5543
              LV    FE  +  F D       ++ ++   E++L+   + EK + +S         A
Sbjct: 1760 --LVTTETFETGVP-FSDLEKLENDIENMLKFVEKHLESSDEDEKMDEES---------A 1807

Query: 5544 QSPDIEHLNEVSLKLPLSDVAVKTLQN----MNRQWIRATATALER------CSELQGIG 5593
            Q  ++    E  L  P+ D   + ++     ++ ++ +  A  +++       S ++   
Sbjct: 1808 QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSL 1867

Query: 5594 LNEKFLYCCEKWIQLLEKIEEALKVDVANSL--PELLEQQKTYKMLEAEVS-INQTIADS 5650
            L   +L    K +  ++ +E +L V   N+    +   Q+ + K ++ ++  + + IA  
Sbjct: 1868 LPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVI 1927

Query: 5651 YVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVE 5710
            +  Q   +L+ +  E   +     ++L  +W    +    RKG  D  + +W+ F   + 
Sbjct: 1928 HEKQPDVILEASGPE-AIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLN 1986

Query: 5711 NLFRFLTDTSHLL--SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKL 5768
            +L +++T+   LL  +   G    SL   ++ IH+ +  E+     + + A     G+ +
Sbjct: 1987 DLTQWITEAEELLVDTCAPGG---SLDLEKARIHQ-QELEVGISSHQPSFAALNRTGDGI 2042

Query: 5769 LLTTDLKTKESVGRRISQLQDSW-------KDMEPQLAEMIKQFQSTVETWDQCEKKIKE 5821
            +          +  +++ L   W       KD +P+L    KQ        D+    + +
Sbjct: 2043 VQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTK 2102

Query: 5822 LKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLT--RHV 5879
             +  +Q      +    EL E+L   ++L +E+E       + LK L   + ++   + +
Sbjct: 2103 AEHAMQ------KRSTTELGENLQELRDLTQEMEVH----AEKLKWLNRTELEMLSDKSL 2152

Query: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVA-----------------------IRKQEIEDRL 5916
             + +   + E +  ++  W  +C  V                        ++K  +    
Sbjct: 2153 SLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSA 2212

Query: 5917 NTWVVFNEKNKELCAWLVQMENKVLQTAD--ISIEEMIEK--LQKDCMEEINL----FSE 5968
            +   V + +  E+      ++  + + AD  + I++M++   +    +EEIN        
Sbjct: 2213 SDIPVQSHRTSEISI-PADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKI 2271

Query: 5969 NKLQLKQMGDQLI-----------KASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
             K  L+Q   QL            KAS+      I +KL ++ ++W      +  R ++L
Sbjct: 2272 TKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQL 2331

Query: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
            ++      Q D +       + + E+ L    +        + K++++ Q L +++    
Sbjct: 2332 EDMIIDSLQWDDHREETEELMRKYEARL---YILQQARRDPLTKQISDNQILLQELGPGD 2388

Query: 6078 AGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRL 6137
              V +  N+   LL +  +     +  ++++TT  L   W N+     +R+  +E  WR 
Sbjct: 2389 GIVMAFDNVLQKLLEEYGS----DDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444

Query: 6138 WQKFLDDYSRFEDWLKSAERT----AACPNSSEVLYTS--AKEELKRFEAFQRQIHERLT 6191
             Q    D   F  W++ AE T        +    L  S  A+E  ++ +  Q +I     
Sbjct: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504

Query: 6192 QLELINKQYRRLARE-NRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEF 6250
              + I+   +++ +    ++ A+ L+  + + NQRW++L+ +  ++   L     +    
Sbjct: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564

Query: 6251 EGTRESILVWLTEMDLQL 6268
              + E ++ WL   D +L
Sbjct: 2565 LMSLEELIKWLNMKDEEL 2582



 Score = 90.9 bits (224), Expect = 4e-17
 Identities = 471/2469 (19%), Positives = 971/2469 (39%), Gaps = 410/2469 (16%)

Query: 1872 EQKLQKLSDFLTLEGRNSKIKQVD--SVLKHVKKHLPKAHVKELISWLVGQEFELEKMES 1929
            E ++Q+    L       +++ +D  S L  V   L K  +++L +WL   E  ++KME+
Sbjct: 387  EFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMET 446

Query: 1930 ICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM--------EEPGEK-TELFC 1980
                    L+D ++ L +L ++H++L+  L  ++ K   +        E  GE  T +  
Sbjct: 447  C------PLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILE 500

Query: 1981 QALARKREQFESVAQLN----NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEED 2036
              L +  E++ +V +      N L+E     +E  ++E  CL+  + T        E+E+
Sbjct: 501  DQLQKLGERWTAVCRWTEERWNRLQEINILWQE--LLEEQCLLKAWLT--------EKEE 550

Query: 2037 KLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLE-ERIQKIKEI------ILL 2089
             L   +  +F D         KE+  S+  L   +  M ++ + + ++ EI      +L 
Sbjct: 551  ALNKVQTSNFKDQ--------KELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLD 602

Query: 2090 KPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSH-QEKLLLEGEKYL 2148
              +   +I +  ++       LVQ+ L D SNQ   T  +A   +S   +K LLE  +  
Sbjct: 603  NSKASKKINSDSEELTQRWDSLVQR-LEDSSNQ--VTQAVAKLGMSQIPQKDLLETVR-- 657

Query: 2149 QSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNY 2208
                 +R   I  K KQE    L      KK Q+ +  +  KK   +++ L     +   
Sbjct: 658  -----VREQAITKKSKQE----LPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKT 708

Query: 2209 LLECTKNPSFSE-EPWLEIKHLHESLLQQLQDSVQNLDG-------HVREHDSYQVCVTD 2260
             ++ T+   + + +   E+K   ++L ++ ++ +   D         V +     +   +
Sbjct: 709  AIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEE 768

Query: 2261 LNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNT 2320
            +   L+  S E+ + S    D   +E K+Q LQE  N    Q   L+K++   +   ++T
Sbjct: 769  IKNVLEKVSSEWKNVSQHLED---LERKIQ-LQEDINAYFKQLDELEKVIKTKEEWVKHT 824

Query: 2321 SSVGQKIIKDDIKSLQCK-QKDLENRLA-SAKQEMECCLNSILKSKRSTE---KKGKFTL 2375
            S    +  +  + SL+   Q++L N L    K EM     S L S+ S     ++G  + 
Sbjct: 825  SI--SESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSF 882

Query: 2376 PGREKQATSDVQESTQE----------SAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQE 2425
             GR +     V++  Q            A +E L+   ++  DS  +  +S  +  +  +
Sbjct: 883  LGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAK 942

Query: 2426 SMKNTEDERKVNE-LQNQPLELDTM------LRNEQLEEIEKLYTQ----LEAKKAAIKP 2474
              K  ++++ ++E L+NQ   L  +      L      ++EKLY Q    ++ K   +K 
Sbjct: 943  VEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKV 1002

Query: 2475 LEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKES----------QYCVLRD 2524
            L   + L+  E  AL L      +  ++  +  +      +++          Q      
Sbjct: 1003 LVSKD-LHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061

Query: 2525 FQEYLAAVESSMKALLTDKESLKVGPL------------DSVTYLDKIKKFIAS----IE 2568
            F   +  +ESS+K +   + +L+ GP+            D  T L+K+ K IA+    + 
Sbjct: 1062 FVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLS 1121

Query: 2569 KEKDSLGNLKIKWENLSNHVTDMDKKL------------LESQIKQLEHGWEQVEQQI-- 2614
            + ++   NLK     +   +T  +++             LES +++++   E V Q+   
Sbjct: 1122 ESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVR 1181

Query: 2615 -------------------QKKYSQQVVEYDEFTTLMNKVQDTEISLQ-------QQQQH 2648
                               Q+  S+  V  + +  L N+++    +L+       +   +
Sbjct: 1182 VKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHY 1241

Query: 2649 LQLR---LKSPEERAGNQSMIALTTDL--QATKHGFSVLKGQA-------ELQMKRIWGE 2696
            L L    L + EER  +  ++   TD   +A +   SVL+  A       EL    I G 
Sbjct: 1242 LDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGG 1301

Query: 2697 KEKKNLEDGINNLKKQWETLEPLHLEAENQI---KKCDIRNKMKETILWAKNLLGELNPS 2753
                 + + +     ++E L   HL    QI   K+  +  +  + +   +  LGEL+  
Sbjct: 1302 ILDDIISEKLEAFNSRYEDLS--HLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQ 1359

Query: 2754 IPLLPDDILSQI---RKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLED 2810
            +     D +      ++ +     I A + ++E L   ++ +   LT+ E          
Sbjct: 1360 LTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQ--PLTSPES-------RT 1410

Query: 2811 LRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAE- 2869
             R   QM VL+   R    +F+L ++   F      Q M+     L   + E    + + 
Sbjct: 1411 ARGGSQMDVLQRKLREVSTKFQLFQKPANFE-----QRMLDCKRVLDGVKAELHVLDVKD 1465

Query: 2870 -----LKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRT 2924
                 ++ H        K L E+   + T ++   +I ++        +++QL +LK+  
Sbjct: 1466 VDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLY 1525

Query: 2925 NRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQE-----EADSIQRNE---LL--LNQEVN 2974
            N +   +     ++E   +  R+  ++ ++L E     E + +Q++    LL  L+ E++
Sbjct: 1526 NDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEIS 1585

Query: 2975 --KGVKEEIYNLKDRLTAI--------------------KCCILQV-LKLKKVFDYIGLN 3011
              K V +++   K  L  I                    + C+L       + +     N
Sbjct: 1586 WAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCN 1645

Query: 3012 WDFSQLDQLQ----------TQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQ 3061
               +  +QL+          T +++ E  L+E  K+  + +EE  K   L+S++   +LQ
Sbjct: 1646 TLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVK--RLVSELDDANLQ 1703

Query: 3062 IKKMTE---VVLKAPDSS------PESRRLNAQI--LSQRIEKAKCLC--DEIIKKLNEN 3108
            ++ + +   +++ A  SS      P+   LN     +SQ I+ AK L   + + + L   
Sbjct: 1704 VENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTT 1763

Query: 3109 KTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQI 3168
            +TF+      ++          +KL   ++NM L+   K L+  +  +K++       + 
Sbjct: 1764 ETFETGVPFSDL----------EKLENDIENM-LKFVEKHLESSDEDEKMD-------EE 1805

Query: 3169 KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVET 3228
             +Q+++ L    E+ H   E +  E  + Q+         + AI  Q+ +    AS + +
Sbjct: 1806 SAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRS 1865

Query: 3229 KLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGN 3288
             L    D  +++N  +     +  D  E      E  T   E              D   
Sbjct: 1866 SLLP-TDYLVEINKIL-----LCMDDVELSLNVPELNTAIYE--------------DFSF 1905

Query: 3289 PEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFK 3348
             E+SL+    + ++L   +A I +    + + +S    +Q++ TL +L +K   +   + 
Sbjct: 1906 QEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYS 1965

Query: 3349 AQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMS---SLPLSYREALERLEQSKA 3405
             ++   +R +E ++ +     D+   +++ E +L  + +   SL L       R+ Q + 
Sbjct: 1966 DRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLE----KARIHQQE- 2020

Query: 3406 LVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCE 3465
            L   + S +     L +    +  + ++ DG  L + ++ L ++W +++   K+ +    
Sbjct: 2021 LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQ---P 2077

Query: 3466 ELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ 3525
             LK E K V +   +   I+  L +    + K       E L EL D   +   + EK +
Sbjct: 2078 RLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLK 2137

Query: 3526 LL----LTLLLQRIRSIQNVPESSGAVETV-PAFQEITSMKERCNKLLQKVQKNKELVQT 3580
             L    L +L  +  S+    + S ++ TV   + +I   +E    L + +Q+   + QT
Sbjct: 2138 WLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKI--CREVPTTLKECIQEPSSVSQT 2195

Query: 3581 EIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEEL-------QSILKKGKL 3633
             I   H   ++++ + +       S +        +  +   EL         +LK   +
Sbjct: 2196 RI-AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIV 2254

Query: 3634 TFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIE 3693
            T  ++ E++    S M  I  A++E +  +       + + + N+   S    A+  K+E
Sbjct: 2255 TVGDV-EEINKTVSRM-KITKADLEQRHPQLDYVF-TLAQNLKNKASSSDMRTAITEKLE 2311

Query: 3694 EINN----GLHNVEKMLQQKSKNI----------EKAQEIQKKMWDEL-DLWHSKLNELD 3738
             + N      H VE   QQ    I          E+ +E+ +K    L  L  ++ + L 
Sbjct: 2312 RVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLT 2371

Query: 3739 SEVQD----IVEQDPGQAQEWMDNLMIPFQQYQQ--VSQRAECRTSQLNKATVKMEEYSD 3792
             ++ D    + E  PG      D +++ F    Q  + +     T  + + T  ++    
Sbjct: 2372 KQISDNQILLQELGPG------DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWI 2425

Query: 3793 LLKSTEAWIENTSH-----LLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
             LK + A  +N        + A+  D ++       A T    L D+  + N L    + 
Sbjct: 2426 NLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILA 2485

Query: 3848 LEDLSIIFETDELTQSIQELSNQVTALQQKIMESL------PQIQRMADDVVAIESEVKS 3901
             E    + +      +  ++   +   +QK++++L        +Q   DD+    +++K+
Sbjct: 2486 RELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKA 2545

Query: 3902 --------MEKRVSKIKTILLS-KEIFDF--SPEEHLKHGEVILENIRPMKKTIAEIVSY 3950
                    +E    K   +L+S +E+  +    +E LK    I  ++  ++       + 
Sbjct: 2546 KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKAL 2605

Query: 3951 QVELRLPQTGM-------------KPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQ 3997
            + EL+  +  +             +P+   +   + LQ  K      +   ++ K + KQ
Sbjct: 2606 RRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS-KTELTPEERAQKIAKAMRKQ 2664

Query: 3998 TNEWDEEIENLKQILNNYSAQFSLEHMSPDQA-DKLPQLQGEIERMEKQILSLNQRKE-- 4054
            ++E  E+ E+L  + +N+  Q        D+A +KL  LQG ++ ++  +      +   
Sbjct: 2665 SSEVKEKWESLNAVTSNWQKQV-------DKALEKLRDLQGAMDDLDADMKEAESVRNGW 2717

Query: 4055 ----DLLVD 4059
                DLL+D
Sbjct: 2718 KPVGDLLID 2726



 Score = 90.1 bits (222), Expect = 7e-17
 Identities = 482/2703 (17%), Positives = 1032/2703 (38%), Gaps = 477/2703 (17%)

Query: 2577 LKIKWENLSNHVTDMDKK------LLESQIKQLEH--GWEQV-EQQIQKKYSQQVVEYDE 2627
            L  +WE L   V  MD++      L+E Q KQL+    W  + E++IQK    +    D+
Sbjct: 397  LNARWEAL--RVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQK---METCPLDD 451

Query: 2628 FTTLMNKVQDTEISLQQQQQHLQLRLKS-------PEERAGNQSMIALTTDLQATKHGFS 2680
                + K+ +   SLQ   +  Q+++ S        +E +G  +   L   LQ     ++
Sbjct: 452  DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWT 511

Query: 2681 VLKGQAELQMKRI------WGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRN 2734
             +    E +  R+      W E  ++        L K W T +    EA N+++  + ++
Sbjct: 512  AVCRWTEERWNRLQEINILWQELLEEQC------LLKAWLTEKE---EALNKVQTSNFKD 562

Query: 2735 KMKETILWAKNL----------------LGELNPSIPLLPDDILSQIRKCKVTHDGILAR 2778
            + KE  +  + L                L E+   +  L D+  +  +K     + +  R
Sbjct: 563  Q-KELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKAS-KKINSDSEELTQR 620

Query: 2779 QQSVESLAEEVKDKVPSLTTYEGSDL---NNTLEDLRNQYQMLVLKSTQ--------RSQ 2827
              S+    E+  ++V       G       + LE +R + Q +  KS Q        + +
Sbjct: 621  WDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKR 680

Query: 2828 QLEFKLEERSNFFAI-------IRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
            Q+   +E +  F AI       I K++  +Q +E     +++  +   E+K     LE  
Sbjct: 681  QIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTS---EMKKKLKALEKE 737

Query: 2881 QKE-LQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVE 2939
            Q+E +   D      L +   I  E    E L  E+ +KN+  + +   + +     ++E
Sbjct: 738  QRERIPRADE-----LNQTGQILVEQMGKEGLPTEE-IKNVLEKVSSEWKNVSQHLEDLE 791

Query: 2940 HKIKFCRQFHEKTSALQEEADSIQR-----NELLLNQEVNKGVKEEIYNLKDRLTAIKCC 2994
             KI    Q  E  +A  ++ D +++      E + +  +++  ++ + +LKD        
Sbjct: 792  RKI----QLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQ----- 842

Query: 2995 ILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSK 3054
                   +++ + +GL+          + +  +    +   +  D+F    G+YQA+   
Sbjct: 843  -------RELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFL---GRYQAVQEA 892

Query: 3055 MRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCD------EIIKKLNEN 3108
            +   D Q     E+  +   +  E+ +    +L+    KA+   +      ++ K L E 
Sbjct: 893  VE--DRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEK 950

Query: 3109 KTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQ-DKLET----SLH 3163
            KT D+  + ++    KL AEE   L K +   V +L  +E D+   + +KL+      LH
Sbjct: 951  KTLDEILENQKPALHKL-AEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLH 1009

Query: 3164 VLNQI---------------------KSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAE 3202
            +L +I                     K  L +      +   +Q + D C AF  ++   
Sbjct: 1010 LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETI 1069

Query: 3203 MCSIKAVTAIEKQREEN--SSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTR 3260
              S+K +  IE        +   + V+T+L +++    +L+  I  + + L+++ E    
Sbjct: 1070 ESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAAN 1129

Query: 3261 YKEAVTRAVESITSLEAIIIPYRVDVGNPEE---SLEMPLRKQEELESTVAHIQDLTEKL 3317
             K+ +    E +T  E   +    +  +PEE   ++E   R +E++      ++ L + +
Sbjct: 1130 LKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNI 1189

Query: 3318 GMISS--PEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNL 3375
             ++++  P    +L   L  ++     +    + +    E   E + C+ ++   +    
Sbjct: 1190 KLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLE---EVWSCWIELLHYLDLET 1246

Query: 3376 SKMETVLGQSMSS--LPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433
            + + T+  +  S+  LP       E LE  ++++ +    + ++ +L Q L         
Sbjct: 1247 TWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI-------- 1298

Query: 3434 NDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELP 3493
             DG  L  I+S   E + S  E                             L +L E   
Sbjct: 1299 -DGGILDDIISEKLEAFNSRYED----------------------------LSHLAES-K 1328

Query: 3494 EISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPA 3553
            +IS  K+     E  ++L  L +    ++KQ  L T L  RI + Q VP+ +  ++   +
Sbjct: 1329 QISLEKQLQVLRETDQMLQVLQESLGELDKQ--LTTYLTDRIDAFQ-VPQEAQKIQAEIS 1385

Query: 3554 FQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQD 3613
              E+T  + R N       +++ L   E +     + ++  L+   ++ +T FQ      
Sbjct: 1386 AHELTLEELRRN------MRSQPLTSPESRTARGGS-QMDVLQRKLREVSTKFQLF---- 1434

Query: 3614 HPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDE 3673
              +K   FE+     K+     + +  +L +   ++  + P  I++ +++C K  + + E
Sbjct: 1435 --QKPANFEQRMLDCKR---VLDGVKAELHVL--DVKDVDPDVIQTHLDKCMKLYKTLSE 1487

Query: 3674 -KISNEVLKSSPSYAMRRKIEEINNGL-----------HNVEKMLQQKSKNIEKAQEIQK 3721
             K+  E +  +  + ++++  +   G+           +++   + +  +++E+A ++ +
Sbjct: 1488 VKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLAR 1547

Query: 3722 KMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLN 3781
            KM  E       L+  ++E   +V++   +    + +L       + V +  E R + LN
Sbjct: 1548 KMKKEAASLSEWLSATETE---LVQKSTSEGL--LGDLDTEISWAKNVLKDLEKRKADLN 1602

Query: 3782 KATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQ--KHN 3839
              T       +L++ +E  +E    L    A +  +RT +       M  ++  +    N
Sbjct: 1603 TITESSAALQNLIEGSEPILEE--RLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGN 1660

Query: 3840 LLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEV 3899
            + H      +  +++ E ++   S QE    V  L  ++ ++  Q++ + D  + +    
Sbjct: 1661 VAHISTWLYQAEALLDEIEKKPTSKQE--EIVKRLVSELDDANLQVENVRDQALIL---- 1714

Query: 3900 KSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQ--VELRLP 3957
              M  R S       S+E+ +    E  ++ E + ++I+  K  IA+   YQ  V     
Sbjct: 1715 --MNARGSS------SRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETF 1766

Query: 3958 QTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSA 4017
            +TG+              D++ LEN                     +IEN+ + +  +  
Sbjct: 1767 ETGVP-----------FSDLEKLEN---------------------DIENMLKFVEKH-- 1792

Query: 4018 QFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEG 4077
               LE  S D+ +K+ +   +IE +        QR E++L          HQ ++  ++ 
Sbjct: 1793 ---LE--SSDEDEKMDEESAQIEEVL-------QRGEEML----------HQPMEDNKKE 1830

Query: 4078 VERDRLPAVTSEEGGVAERDASERKLNR--RGSMSYLAAVEEEVEESSVKSDNGDEKAEP 4135
              R +L  + +    +      +RK+ +   G  S L   +  VE + +     D +   
Sbjct: 1831 KIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSL 1890

Query: 4136 SPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC- 4194
            +    ++    D   +ED   +     +++   K+     ++     PD +    GPE  
Sbjct: 1891 NVPELNTAIYEDFSFQEDSLKN-----IKDQLDKLG-EQIAVIHEKQPDVILEASGPEAI 1944

Query: 4195 SLRPNQTEEGTTPPIEADTLDS--SDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWL 4252
             +R   T+       + D ++   SD +G  +  +E+ R       H     + +L  W+
Sbjct: 1945 QIRDTLTQLNA----KWDRINRMYSDRKGCFDRAMEEWRQ-----FHC---DLNDLTQWI 1992

Query: 4253 QQA-----NVAVEPETLNADMQQVLEQQL-VGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
             +A     +      +L+ +  ++ +Q+L VG  +      H+ +F        G+    
Sbjct: 1993 TEAEELLVDTCAPGGSLDLEKARIHQQELEVGISS------HQPSFAALNRTGDGIVQKL 2046

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
            +   +A+   LK K    N     ++ + K  + +     K+  +  HQ       L E+
Sbjct: 2047 S---QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQ-------LDEI 2096

Query: 4367 ESIVTERPQFSRQKDFQQQQVLELKP--MEQKDFIKFIEFNAKKMWPQYCQHDNDTTQES 4424
               +T+      +   Q++   EL     E +D  + +E +A+K+     +  N T  E 
Sbjct: 2097 ICWLTKA-----EHAMQKRSTTELGENLQELRDLTQEMEVHAEKL-----KWLNRTELEM 2146

Query: 4425 SASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPS 4484
             +    S PE D     L         W  +  E+ + +K    + ++   S +   + +
Sbjct: 2147 LSDKSLSLPERDKISESLRTVNMT---WNKICREVPTTLK----ECIQEPSSVSQTRIAA 2199

Query: 4485 VTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYI--NLDKKLFEL---FLT 4539
                   +P  +++         L   AS++  Q + T E  I  +LDK + EL    + 
Sbjct: 2200 -------HPNVQKVV--------LVSSASDIPVQSHRTSEISIPADLDKTITELADWLVL 2244

Query: 4540 LSQCLSS-------VEEM------LEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK 4586
            + Q L S       VEE+      +++ +   E    Q  +  TLA  LK          
Sbjct: 2245 IDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN-----KASS 2299

Query: 4587 GDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGL------DYNRSYQN 4640
             D+  A+T          E  + ++   + TQ     R + L+  +      D +R    
Sbjct: 2300 SDMRTAIT----------EKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETE 2349

Query: 4641 EIKRLYHQ--LIKSKTSLQQSLNEIS-GQSVAEQLQKADAYTVELENAESRVAK------ 4691
            E+ R Y     I  +        +IS  Q + ++L   D   +  +N   ++ +      
Sbjct: 2350 ELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDD 2409

Query: 4692 ---LRDEGERLHLPYA-LLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGM 4747
               +++  E L   +  L Q +   ++ L++ W  ++A   +L +      + +  +  +
Sbjct: 2410 TRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVL 2469

Query: 4748 VELV---KIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVAD-MLLIQAYSAKILPS 4803
            V+        ++ +    LKQ    +  QA+I+ H   F+ +  +   +++A       +
Sbjct: 2470 VDASHRENALQDSILARELKQQMQDI--QAEIDAHNDIFKSIDGNRQKMVKALGNSEEAT 2527

Query: 4804 LLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPS 4863
            +LQ+R     ++  ++K    KS      L++  +KW     +   L K L +    L  
Sbjct: 2528 MLQHRLDDMNQRWNDLKA---KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKK 2584

Query: 4864 VSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVAS--VSCPE-------- 4913
               +      L  +    + ++R +  K   +   +++ +  +A   +  PE        
Sbjct: 2585 QMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQS 2644

Query: 4914 ----------------LEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLT 4957
                            +  Q ++++E+W SLN    +   ++   L+ L       D L 
Sbjct: 2645 KTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLD 2704

Query: 4958 KWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLH 5017
              ++ ++   N WK         +D+++ +I     F +E+   +     V  + +QL  
Sbjct: 2705 ADMKEAESVRNGWKPVG---DLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761

Query: 5018 LKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRK---AITEMISWMNN 5074
            L    +  +   L     +W +L   + D  ++L +   +  PS +   + +  + W  +
Sbjct: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRS 2821

Query: 5075 VEH 5077
            + H
Sbjct: 2822 ISH 2824



 Score = 86.3 bits (212), Expect = 1e-15
 Identities = 262/1412 (18%), Positives = 545/1412 (38%), Gaps = 179/1412 (12%)

Query: 4775 QIENHKVFFQKLVADML----LIQAYSAKILPSLLQNRETFWA-EQVT------EVKILE 4823
            Q   H+ F  +L A       ++QA +  I    L + E F   EQ+T      E   +E
Sbjct: 348  QFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVE 407

Query: 4824 EKSRQCGMK--LQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFY 4881
               RQ  +   L  L +K  +    + +L ++    + T P    V+  ++ L E  S  
Sbjct: 408  SMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQ 467

Query: 4882 -----QQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHEL 4936
                 +Q+K N    H  +    N G+   A      LE Q+ KL E+W ++ +  +   
Sbjct: 468  SDLEAEQVKVN-SLTHMVVIVDENSGESATAI-----LEDQLQKLGERWTAVCRWTEERW 521

Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
            +RLQ +         +   L  WL   +  LN  K Q+ N  +D   +  ++       +
Sbjct: 522  NRLQEINILWQELLEEQCLLKAWLTEKEEALN--KVQTSNF-KDQKELSVSVRRLAILKE 578

Query: 4997 EVDEKSSLKTAVISIGNQLLHLKETDTAT--LRASLAQFEQKWTMLITQLPDIQEKLHQ- 5053
            +++ K      +  IG  +  L +   A+  + +   +  Q+W  L+ +L D   ++ Q 
Sbjct: 579  DMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQA 638

Query: 5054 ---LQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEF-RMEMD 5109
               L M ++P +  +  +      +  ++  E     P    Q+   ++  K+F  +  +
Sbjct: 639  VAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAE 698

Query: 5110 YKQWIVDF--------VNQSLLQLSTCDVESK----------RYERTE--------FAEH 5143
               WI+ +        + + +    T +++ K          R  R +          E 
Sbjct: 699  LLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQ 758

Query: 5144 LGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI---LNNWLEAQEERLKTLQKPE 5200
            +G+       +  +L +     + + + + + E KIQ+   +N + +  +E  K ++  E
Sbjct: 759  MGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKE 818

Query: 5201 SVI-----------SVQKLLLDCQ-DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTA 5248
              +           S+  L   CQ ++ N L +  K ++  + S   L S   P   D  
Sbjct: 819  EWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPK-IEMARASCSALMSQ--PSAPDFV 875

Query: 5249 SRIDELFQKRSSVLTQV---------NQLKTSM-QSVLQEWK-IYDQLYDEVNMMTIRFW 5297
             R  + F  R   + +          N+LK     + L+  K + D L D  N   +   
Sbjct: 876  QRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQV--- 932

Query: 5298 YCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKL-KGLCPSVAEIIE 5356
                 S  V+  L  +   ++  ++L +  E+ + +  KL E    L K + P V ++ +
Sbjct: 933  -----SLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYK 987

Query: 5357 EKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSN--------AHGEAAARLKQQEAKF 5408
            ++  +   +W ++   ++  L   + +    +A+            G     +KQQ A+ 
Sbjct: 988  QEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQG 1047

Query: 5409 ------QQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAES 5462
                  +QL   S   N + E +  +L+++KE++ +++    A ++ + V  RL    + 
Sbjct: 1048 DDAGLQRQLDQCSAFVNEI-ETIESSLKNMKEIETNLRSGPVAGIK-TWVQTRL---GDY 1102

Query: 5463 STHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDR 5522
             T       L  L +    +K  L ++ E    L   KD     E  + +   EEE L+R
Sbjct: 1103 QTQ------LEKLSKEIATQKSRLSESQEKAANLK--KDLA---EMQEWMTQAEEEYLER 1151

Query: 5523 LHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ--NMNRQWIRATA 5580
                E ++P+   + V  +     D+    EV +K+   ++ +   +  +  ++      
Sbjct: 1152 --DFEYKSPEELESAVEEMKRAKEDVLQ-KEVRVKILKDNIKLLAAKVPSGGQELTSELN 1208

Query: 5581 TALER----CSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKM 5636
              LE     C+ ++G     + ++ C  WI+LL  ++  L+    N+L E        +M
Sbjct: 1209 VVLENYQLLCNRIRGKCHTLEEVWSC--WIELLHYLD--LETTWLNTLEE--------RM 1256

Query: 5637 LEAEVSINQTIADSYVTQSLQLL------DTTEIENRPEFITEFSKLTDRWQNAVQGVRQ 5690
               EV   +T A +   +SL+ +      + T+I    + + +   L D     ++    
Sbjct: 1257 KSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNS 1316

Query: 5691 RKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQ-----ERFSLYQTRSL-IHEL 5744
            R  D+  L    Q    S+E   + L +T  +L  ++       ++ + Y T  +   ++
Sbjct: 1317 RYEDLSHLAESKQ---ISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQV 1373

Query: 5745 KNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQ 5804
              +    Q   +   LTLE   + + +  L + ES   R     D  +    +++   + 
Sbjct: 1374 PQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQL 1433

Query: 5805 FQSTVETWDQ---CEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASW 5861
            FQ       +   C++ +  +K+ L VL  +  DP     + +    +   +L ++L+  
Sbjct: 1434 FQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDP-----DVIQTHLDKCMKLYKTLSEV 1488

Query: 5862 TQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVV 5921
               ++ +      + +    ++   + EQ+  L   + DL  +V   KQ++E        
Sbjct: 1489 KLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARK 1548

Query: 5922 FNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSE---NKLQLKQMGD 5978
              ++   L  WL   E +++Q +  + E ++  L  +     N+  +    K  L  + +
Sbjct: 1549 MKKEAASLSEWLSATETELVQKS--TSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE 1606

Query: 5979 QLIKASNKSRAAE--IDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRT 6036
                  N    +E  ++++L  +N  W  +          L      ++  D N++++ T
Sbjct: 1607 SSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHIST 1666

Query: 6037 WLARIESELSKPVVYDVCDDQEIQKRLAEQQD 6068
            WL + E+ L +         +EI KRL  + D
Sbjct: 1667 WLYQAEALLDEIEKKPTSKQEEIVKRLVSELD 1698



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 241/1269 (18%), Positives = 482/1269 (37%), Gaps = 181/1269 (14%)

Query: 5182 LNNWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELK--QSYL--TL 5236
            L+++  A EE L  L   E     Q  + D  +++++Q A     + EL   QS +   L
Sbjct: 311  LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370

Query: 5237 ESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYD--EVNMMTI 5294
            ++G   + + T S  +E   +    L         ++S+ ++ +++D L +  +  +  +
Sbjct: 371  QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL 430

Query: 5295 RFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAE- 5353
              W  +   +   +    L   V++LQ L +E +S +   E  Q  +  L  +   V E 
Sbjct: 431  SAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDEN 490

Query: 5354 -------IIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLW----------KAYSNAHGE 5396
                   I+E++ Q   +RWT V +   ++  + Q +  LW          KA+     E
Sbjct: 491  SGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEE 550

Query: 5397 AAARLKQQEAKFQQLANISMSGNNLA------EILPPALQDIKELQHDVQKTKEAFLQNS 5450
            A  ++  Q + F+    +S+S   LA      E+    L  + E+  DV +     L NS
Sbjct: 551  ALNKV--QTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQ----LLDNS 604

Query: 5451 SVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLK 5510
                ++   +E  T           QR   L + L   +N+    +++     +  + L 
Sbjct: 605  KASKKINSDSEELT-----------QRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLL 653

Query: 5511 GLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQN 5570
              +   E+ + +  +QE   P       + +     DIE   +        D     L N
Sbjct: 654  ETVRVREQAITKKSKQELPPPPPPKKRQIHV-----DIEAKKKF-------DAISAELLN 701

Query: 5571 MNRQWIRATATA-LERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLE 5629
               +W  A  T  ++   ++Q     +K L   EK     E+ E   + D  N   ++L 
Sbjct: 702  WILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEK-----EQRERIPRADELNQTGQILV 756

Query: 5630 QQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR 5689
            +Q                         + L T EI+N  E      K++  W+N  Q + 
Sbjct: 757  EQ----------------------MGKEGLPTEEIKNVLE------KVSSEWKNVSQHLE 788

Query: 5690 ------QRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTR-SLIH 5742
                  Q + D++   +Q  +    ++    ++  TS     +    R SL   + S   
Sbjct: 789  DLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTS-----ISESSRQSLPSLKDSCQR 843

Query: 5743 ELKNK-EIH--FQRRRTTCALTLEAGEKLLLTTDLKTK--ESVGRRISQLQDSWKDMEPQ 5797
            EL N   +H   +  R +C+  +          D   +  +S   R   +Q++ +D +  
Sbjct: 844  ELTNLLGLHPKIEMARASCSALMSQPS----APDFVQRGFDSFLGRYQAVQEAVEDRQQH 899

Query: 5798 LAEMIK--QFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELE 5855
            L   +K     + +ET    +  + + +++ QV      D L ++ + L  +K L + LE
Sbjct: 900  LENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLND-LAKVEKALQEKKTLDEILE 958

Query: 5856 QSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDR 5915
                +  +  +E + ++ ++  H  VE +   K++ + +  +W  L + V+     +E+ 
Sbjct: 959  NQKPALHKLAEETKALEKNV--HPDVEKLY--KQEFDDVQGKWNKLKVLVSKDLHLLEEI 1014

Query: 5916 LNTWVVFNEKNKELCAWL-----VQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENK 5970
              T   F   +  +  W+       M+ +  Q  D  ++  +++     + EI     + 
Sbjct: 1015 ALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA-FVNEIETIESSL 1073

Query: 5971 LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKN 6030
              +K++   L           +  +L     + + L   I ++  +L E+      L K+
Sbjct: 1074 KNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKD 1133

Query: 6031 MSNLRTWLARIESE-LSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDV 6089
            ++ ++ W+ + E E L +   Y     +E++  + E +  + D+ Q    V+ + +   +
Sbjct: 1134 LAEMQEWMTQAEEEYLERDFEYK--SPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKL 1191

Query: 6090 LLHDSDACANE--TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSR 6147
            L     +   E  +E + + +  + L  R R  C         +EE W  W + L     
Sbjct: 1192 LAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHT-------LEEVWSCWIELLHYLDL 1244

Query: 6148 FEDWLKSAERTAACPNSSEVL---YTSAKEELKRFEAFQRQIHERLTQLELINKQ----- 6199
               WL + E       S+EVL     +  E L+  E+  R   +  TQ+  + +      
Sbjct: 1245 ETTWLNTLEERM---KSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGG 1301

Query: 6200 -YRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESIL 6258
                +  E      SR + + H    +  +L++++  VLR         +E  G      
Sbjct: 1302 ILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQL-QVLRETDQMLQVLQESLG------ 1354

Query: 6259 VWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLD 6318
                E+D QLT        DA    ++    Q EI+ +   +++L     +   +S+PL 
Sbjct: 1355 ----ELDKQLTTY-LTDRIDAFQVPQEAQKIQAEISAHELTLEEL-----RRNMRSQPLT 1404

Query: 6319 AVLIE-----DELEELHRYCQEV------FGRVSRFHRRLTSCTPGLEDEK-EASENETD 6366
            +          +++ L R  +EV      F + + F +R+  C   L+  K E    +  
Sbjct: 1405 SPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVK 1464

Query: 6367 MEDPREIQT 6375
              DP  IQT
Sbjct: 1465 DVDPDVIQT 1473



 Score = 73.9 bits (180), Expect = 5e-12
 Identities = 189/945 (20%), Positives = 364/945 (38%), Gaps = 150/945 (15%)

Query: 5502 FGVRLESLKGLIMHEEENL---DRLHQQEKENPDSFLNH---VLALTAQSPDIEHL---- 5551
            + + LE +   ++  E+     D +    +E  D F  H   ++ LTA    +  +    
Sbjct: 314  YQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAG 373

Query: 5552 NEVSLKLPLSDVAVKTLQN----MNRQWIRATATALERCSELQGI--GLNEKFLYCCEKW 5605
            N++  +  LSD     +Q     +N +W      +++R S L  +   L +K L     W
Sbjct: 374  NQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAW 433

Query: 5606 IQLLE----KIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDT 5661
            + L E    K+E     D   SL +LLE+ K+   L++++   Q   +S +T  + ++D 
Sbjct: 434  LTLTEERIQKMETCPLDDDVKSLQKLLEEHKS---LQSDLEAEQVKVNS-LTHMVVIVDE 489

Query: 5662 TEIENRPEFITE-FSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS 5720
               E+    + +   KL +RW    +   +R   +  +   WQ+       L  +LT+  
Sbjct: 490  NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549

Query: 5721 HLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESV 5780
              L+ V         QT +   +   KE+    RR   A+  E  E    T D  ++  +
Sbjct: 550  EALNKV---------QTSNFKDQ---KELSVSVRRL--AILKEDMEMKRQTLDQLSE--I 593

Query: 5781 GRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPEL 5840
            G+ + QL D+ K  +    ++    +   + WD                           
Sbjct: 594  GQDVGQLLDNSKASK----KINSDSEELTQRWDS-------------------------- 623

Query: 5841 HEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWED 5900
                     L++ LE S    TQ + +L    + + +  L+E V V ++ I    +Q  +
Sbjct: 624  ---------LVQRLEDSSNQVTQAVAKLGM--SQIPQKDLLETVRVREQAITKKSKQ--E 670

Query: 5901 LCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADIS----------IEE 5950
            L      +K++I   +     F+  + EL  W+++ +  + QT +I           +++
Sbjct: 671  LPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAI-QTTEIKEYMKMQDTSEMKK 729

Query: 5951 MIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSR--AAEIDDKLNKINDRW----Q 6004
             ++ L+K+  E I    E    L Q G  L++   K      EI + L K++  W    Q
Sbjct: 730  KLKALEKEQRERIPRADE----LNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQ 785

Query: 6005 HLFDVIGSRVKKLKETFAFIQQLDKNMSNLRT---WLARIE----SELSKPVVYDVCDDQ 6057
            HL D +  +++  ++  A+ +QLD+    ++T   W+        S  S P + D C   
Sbjct: 786  HLED-LERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSC--- 841

Query: 6058 EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRW 6117
              Q+ L     L   IE   A        C  L+    A       D +Q+   S   R+
Sbjct: 842  --QRELTNLLGLHPKIEMARAS-------CSALMSQPSAP------DFVQRGFDSFLGRY 886

Query: 6118 RNICAMSMERRMKIEETWR--LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
            + +     +R+  +E   +      +L+     +D L  +E  A    S  VL   AK E
Sbjct: 887  QAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQV--SLNVLNDLAKVE 944

Query: 6176 --LKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRV 6233
              L+  +     +  +   L  + ++ + L +    D     KQ   +   +W+ L+  V
Sbjct: 945  KALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLV 1004

Query: 6234 TAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDA--DDKMRQLNGFQQ 6291
            +  L  L         FE     I  W+  +   L   +     DA    ++ Q + F  
Sbjct: 1005 SKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVN 1064

Query: 6292 EITLNTNKIDQLIVFGEQLIQKSEPLDAV--LIEDELEELHRYCQEVFGRVSRFHRRLTS 6349
            EI    + +  +      L  +S P+  +   ++  L +     +++   ++    RL+ 
Sbjct: 1065 EIETIESSLKNMKEIETNL--RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLS- 1121

Query: 6350 CTPGLEDEKEASENETDMEDPREIQTDSWRKRGESE-EPSSPQSL 6393
                 E +++A+  + D+ + +E  T +  +  E + E  SP+ L
Sbjct: 1122 -----ESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEEL 1161



 Score = 73.2 bits (178), Expect = 9e-12
 Identities = 311/1743 (17%), Positives = 673/1743 (38%), Gaps = 282/1743 (16%)

Query: 2171 LQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTK--NPSFSEEPWLEIKH 2228
            L+H   + +  L I K  L   +D+   L + KS   YL    +      + +   E++ 
Sbjct: 211  LEHAFSKAQTYLGIEK--LLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVET 268

Query: 2229 LHESLLQQLQDSVQNLDGHV--REHDSYQV----CVTDLNTTLDNFSKEFVSFSDKPVDQ 2282
            L     ++ ++   N+       EH+S +      VT+++  LD++             Q
Sbjct: 269  LPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSY-------------Q 315

Query: 2283 IAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDL 2342
            IA+EE L  L   E+    QD        ++  V++         +KD   + +    +L
Sbjct: 316  IALEEVLTWLLSAEDTFQEQDD-------ISDDVEE---------VKDQFATHEAFMMEL 359

Query: 2343 ENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEED 2402
                +S    ++     I +   S E++        E Q    +  +  E+  VE ++  
Sbjct: 360  TAHQSSVGSVLQAGNQLITQGTLSDEEEF-------EIQEQMTLLNARWEALRVESMDRQ 412

Query: 2403 WEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLY 2462
              ++ D  +E+   KQL    Q S   T  E ++ +++  PL+ D     + LEE + L 
Sbjct: 413  SRLH-DVLMEL-QKKQLQ---QLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQ 467

Query: 2463 TQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVL 2522
            + LEA++  +  L     +    +G      +    Q L     A+    + + ++   +
Sbjct: 468  SDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527

Query: 2523 RDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWE 2582
                + L   +  +KA LT+KE   +  + +  + D+ K+   S+ +      ++++K +
Sbjct: 528  NILWQELLEEQCLLKAWLTEKEE-ALNKVQTSNFKDQ-KELSVSVRRLAILKEDMEMKRQ 585

Query: 2583 NL-------------------SNHVTDMDKKLL---ESQIKQLEHGWEQVEQQIQKKYSQ 2620
             L                   S  +    ++L    +S +++LE    QV Q + K    
Sbjct: 586  TLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMS 645

Query: 2621 QVVEYDEFTTLMNKVQDTEISLQQQQQ------------HLQLRLKSPEERAGNQSM--- 2665
            Q+ + D   T+  +V++  I+ + +Q+            H+ +  K   +    + +   
Sbjct: 646  QIPQKDLLETV--RVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI 703

Query: 2666 IALTTDLQATK-HGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAE 2724
            +   T +Q T+   +  ++  +E++ K    EKE++      + L +  + L  +    +
Sbjct: 704  LKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQIL--VEQMGK 761

Query: 2725 NQIKKCDIRNKMKETILWAKNL---LGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
              +   +I+N +++     KN+   L +L   I  L +DI +  ++       I  +++ 
Sbjct: 762  EGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQ-LQEDINAYFKQLDELEKVIKTKEEW 820

Query: 2782 VE--SLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNF 2839
            V+  S++E  +  +PSL      +L N L  L  + +M     +    Q       +  F
Sbjct: 821  VKHTSISESSRQSLPSLKDSCQRELTNLL-GLHPKIEMARASCSALMSQPSAPDFVQRGF 879

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELT 2899
             + + ++Q  VQE+   +  R +    E + +  H  LE + K L+++ +      Q   
Sbjct: 880  DSFLGRYQ-AVQEA---VEDRQQHLENELKGQPGHAYLE-TLKTLKDVLNDSENKAQVSL 934

Query: 2900 NIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEV-EHKIKFCRQFHEKTSALQEE 2958
            N+  +L   E+   E                 + T +E+ E++     +  E+T AL++ 
Sbjct: 935  NVLNDLAKVEKALQE-----------------KKTLDEILENQKPALHKLAEETKALEKN 977

Query: 2959 ADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVF----------DYI 3008
                      ++ +V K  K+E  +++ +   +K  + + L L +              +
Sbjct: 978  ----------VHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTV 1027

Query: 3009 GLNWDFSQLDQLQTQVFEK--EKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKK-- 3064
               W     D L  Q   +  +  L+ ++ Q   F  E    ++ L  M+ I+  ++   
Sbjct: 1028 IEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGP 1087

Query: 3065 ----MTEVVLKAPDSSPESRRLNAQI------LSQRIEKAKCLCDEIIKKLNENKTFDDS 3114
                 T V  +  D   +  +L+ +I      LS+  EKA  L  ++ +        ++ 
Sbjct: 1088 VAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEE 1147

Query: 3115 FKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ 3174
            + E++  + K + EE +   + ++    ++  KE+  K  +D ++     +     +L  
Sbjct: 1148 YLERD-FEYK-SPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTS 1205

Query: 3175 PLLINLEIKHI--QNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLRE 3232
             L + LE   +     +  C    E+VW+  C I+ +  ++ +    ++  + +E +++ 
Sbjct: 1206 ELNVVLENYQLLCNRIRGKCHTL-EEVWS--CWIELLHYLDLE----TTWLNTLEERMKS 1258

Query: 3233 FEDLQMQ---LNTSIDLRTNVLNDAYENLTRYKEAVTRAVES-------ITSLEAIIIPY 3282
             E L  +   +N +++   +VL    +N T+ +E     ++           LEA    Y
Sbjct: 1259 TEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRY 1318

Query: 3283 RVDVGNPEESLEMPLRKQ-EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNS 3341
              D+ +  ES ++ L KQ + L  T   +Q L E LG     E   QL   L + +    
Sbjct: 1319 E-DLSHLAESKQISLEKQLQVLRETDQMLQVLQESLG-----ELDKQLTTYLTDRIDAFQ 1372

Query: 3342 AMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREA---LE 3398
              +EA K Q   +   L   +  R M     T+        G  M  L    RE     +
Sbjct: 1373 VPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQ 1432

Query: 3399 RLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAK 3458
              ++       ++  K  L  ++  L +L ++  + D      ++    +K + L +   
Sbjct: 1433 LFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPD------VIQTHLDKCMKLYKTLS 1486

Query: 3459 EWEMWCEELKQEWKFV---------------------------------SEEIEREAIIL 3485
            E ++  E + +  + +                                  +++ER + + 
Sbjct: 1487 EVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLA 1546

Query: 3486 DNLQEELPEISKTKEA--------ATTEELSELLDCLCQYGENV----EKQQLLLTLLLQ 3533
              +++E   +S+   A        +T+E L   LD    + +NV    EK++  L  + +
Sbjct: 1547 RKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITE 1606

Query: 3534 RIRSIQNVPESSG-------AVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERH 3586
               ++QN+ E S         V      +  T  ++ CN L+   Q   E+    +    
Sbjct: 1607 SSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNH-QNQLEIFDGNVAHIS 1665

Query: 3587 SFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKY 3646
            ++  +  AL +  ++  TS          ++ E  + L S L    L  EN+ ++  I  
Sbjct: 1666 TWLYQAEALLDEIEKKPTS----------KQEEIVKRLVSELDDANLQVENVRDQALILM 1715

Query: 3647 SEMYTIVPAEIESQVEECRKALEDIDEKISNE--VLKSSPSYAMRRKIEEINNGL----- 3699
            +   +     +E ++ E  +  E + + I +   ++   P Y      E    G+     
Sbjct: 1716 NARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDL 1775

Query: 3700 ----HNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEW 3755
                +++E ML+   K++E + E      DE      K++E  +++++++++      + 
Sbjct: 1776 EKLENDIENMLKFVEKHLESSDE------DE------KMDEESAQIEEVLQRGEEMLHQP 1823

Query: 3756 MDN 3758
            M++
Sbjct: 1824 MED 1826



 Score = 68.6 bits (166), Expect = 2e-10
 Identities = 347/1937 (17%), Positives = 751/1937 (38%), Gaps = 301/1937 (15%)

Query: 4481 ILPSVTMYNFRYPTTE-ELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLT 4539
            I   +T+ N R+     E     ++L D+  E    Q Q+     A++ L ++  +   T
Sbjct: 390  IQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQL---SAWLTLTEERIQKMET 446

Query: 4540 --LSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPG 4597
              L   + S++++LE  +  + D   +QV   +L        + + D+           G
Sbjct: 447  CPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTH-----MVVIVDENS---------G 492

Query: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSK---- 4653
            E+   +LE  D LQ   E     AVCR    +    +NR    EI  L+ +L++ +    
Sbjct: 493  ESATAILE--DQLQKLGERW--TAVCRWTEER----WNRL--QEINILWQELLEEQCLLK 542

Query: 4654 ---TSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVY 4710
               T  +++LN++   +  +Q         EL  +  R+A L+++ E        L E+ 
Sbjct: 543  AWLTEKEEALNKVQTSNFKDQK--------ELSVSVRRLAILKEDMEMKRQTLDQLSEIG 594

Query: 4711 K-LEDVLDSMWGM--LRARYTELSSPF--VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
            + +  +LD+      + +   EL+  +  + +  +D+  Q    + K+G  ++    L +
Sbjct: 595  QDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLE 654

Query: 4766 T----------KSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQ 4815
            T          KSK  L       K      +       A SA++L  +L+ +    A Q
Sbjct: 655  TVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKT---AIQ 711

Query: 4816 VTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLV 4875
             TE+K          MK+Q       E  +   +LEK+       +P    + +T + LV
Sbjct: 712  TTEIKEY--------MKMQDT----SEMKKKLKALEKEQR---ERIPRADELNQTGQILV 756

Query: 4876 ERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE 4935
            E++                       GK+    +   E++  + K+  +W ++++ ++ +
Sbjct: 757  EQM-----------------------GKE---GLPTEEIKNVLEKVSSEWKNVSQHLE-D 789

Query: 4936 LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWK--EQSLNVSQDL-DTIRSNINNFF 4992
            L R   L + + +Y +  D+L K +++ +  + +    E S      L D+ +  + N  
Sbjct: 790  LERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLL 849

Query: 4993 EFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLH 5052
                +++   +  +A++S        + +    ++     F  ++  +   + D Q+ L 
Sbjct: 850  GLHPKIEMARASCSALMS--------QPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLE 901

Query: 5053 QLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQ 5112
              +++  P   A  E +  + +V +     DS +    +  V + L K ++   E     
Sbjct: 902  N-ELKGQPGH-AYLETLKTLKDVLN-----DSENKAQVSLNVLNDLAKVEKALQEKKTLD 954

Query: 5113 WIVDFVNQSLLQLSTCDVESKRYERTE-------FAEHLGEMNRQWHRVHGMLNRKIQHL 5165
             I++    +L +L+    E+K  E+         + +   ++  +W+++  ++++ +  L
Sbjct: 955  EILENQKPALHKLAE---ETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLL 1011

Query: 5166 EQLLESITESENKIQILNNWLEAQEERLKTLQKPESV-ISVQKLLLDCQDIENQLAIKSK 5224
            E++  ++   E    ++  W++  ++ L   Q  +     +Q+ L  C    N++     
Sbjct: 1012 EEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES 1071

Query: 5225 ALDELKQSYLTLESGAVP--------LLEDTASRIDELFQKRSSVLTQVNQLKTSMQSV- 5275
            +L  +K+    L SG V          L D  +++++L ++   + TQ ++L  S +   
Sbjct: 1072 SLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKE---IATQKSRLSESQEKAA 1128

Query: 5276 --------LQEWKIY-DQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE 5326
                    +QEW    ++ Y E +          E+  P     E L   VE ++  +++
Sbjct: 1129 NLKKDLAEMQEWMTQAEEEYLERDF---------EYKSP-----EELESAVEEMKRAKED 1174

Query: 5327 AESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQ-KAQSLLQ 5385
                E   + L++ I  L    PS  + +  +     + +    Q + ++++ K  +L +
Sbjct: 1175 VLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENY----QLLCNRIRGKCHTLEE 1230

Query: 5386 LWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEA 5445
            +W  +     E    L  +      L     S     E+LP     + E    ++     
Sbjct: 1231 VWSCWI----ELLHYLDLETTWLNTLEERMKS----TEVLPEKTDAVNEALESLESV--- 1279

Query: 5446 FLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVR 5505
                      L  PA++ T +   G   +L     L+ ++  K   F    S+++D    
Sbjct: 1280 ----------LRHPADNRTQIRELG--QTLIDGGILDDIISEKLEAFN---SRYEDLSHL 1324

Query: 5506 LESL-----KGL-IMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDI-EHLNEVSLKL 5558
             ES      K L ++ E + + ++ Q+     D  L   L     +  + +   ++  ++
Sbjct: 1325 AESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEI 1384

Query: 5559 PLSDVAVKTLQ-NMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
               ++ ++ L+ NM  Q + +  +   R      + L  K      K+ QL +K      
Sbjct: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDV-LQRKLREVSTKF-QLFQK------ 1436

Query: 5618 VDVANSLPELLEQQKTYKMLEAEV------SINQTIADSYVTQSLQLLDTTEIENRPEFI 5671
               AN    +L+ ++    ++AE+       ++  +  +++ + ++L  T       E  
Sbjct: 1437 --PANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLS-----EVK 1489

Query: 5672 TEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQER 5731
             E   +    ++ VQ  +Q+  +  G+  Q         +L   +T+    L       R
Sbjct: 1490 LEVETVIKTGRHIVQ--KQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLAR 1547

Query: 5732 FSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLL----LTTDLKTKESVGRRISQ- 5786
                +  SL   L   E    ++ T+  L  +   ++     +  DL+ +++    I++ 
Sbjct: 1548 KMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITES 1607

Query: 5787 ---LQDSWKDMEPQLAE---MIKQFQSTVETW--DQCEKKIKELKSRLQVLKA------- 5831
               LQ+  +  EP L E   ++    S V TW  D C   +   +++L++          
Sbjct: 1608 SAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNH-QNQLEIFDGNVAHIST 1666

Query: 5832 ---QSEDPLPELHED-LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVL 5887
               Q+E  L E+ +     ++E++K L   L      ++ ++     L          ++
Sbjct: 1667 WLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELV 1726

Query: 5888 KEQIEHLHRQWEDLCLRVAIRKQEI-EDRLNTWVVFNEKNKELCAWLVQMENKVLQTADI 5946
            + ++  L+R +E +   +   K  I ++ L   +V  E       +   +    L+  + 
Sbjct: 1727 EPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTE------TFETGVPFSDLEKLEN 1780

Query: 5947 SIEEMIEKLQK--DCMEEINLFSENKLQLK---QMGDQLIKASNKSRAAEIDDKLNKIND 6001
             IE M++ ++K  +  +E     E   Q++   Q G++++    +      D+K  KI  
Sbjct: 1781 DIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPME------DNKKEKI-- 1832

Query: 6002 RWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQK 6061
            R Q L  ++ +R  K+K      +++ +  S +R+ L   +  +    +    DD E+  
Sbjct: 1833 RLQLL--LLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSL 1890

Query: 6062 RLAEQQDLQRDIEQHSAGVESVFNICDVL--LHDSDACANETECD-----------SIQQ 6108
             + E        E  S   +S+ NI D L  L +  A  +E + D            I+ 
Sbjct: 1891 NVPELNTAI--YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRD 1948

Query: 6109 TTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER--TAACPNSSE 6166
            T   L+ +W  I  M  +R+   +     W++F  D +    W+  AE      C     
Sbjct: 1949 TLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGS 2008

Query: 6167 VLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRW 6226
            +    A+   +  E     I         +N+    + ++      S LK+ +   NQRW
Sbjct: 2009 LDLEKARIHQQELEV---GISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRW 2065

Query: 6227 DNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQL 6286
            D +   V     RL+  + Q  ++    + I+ WLT+ +  +   +  S ++  + +++L
Sbjct: 2066 DAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAM---QKRSTTELGENLQEL 2122

Query: 6287 NGFQQEITLNTNKIDQL 6303
                QE+ ++  K+  L
Sbjct: 2123 RDLTQEMEVHAEKLKWL 2139



 Score = 49.7 bits (117), Expect = 1e-04
 Identities = 108/631 (17%), Positives = 244/631 (38%), Gaps = 111/631 (17%)

Query: 5623 SLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENR-------PEFITEFS 5675
            SL E+L QQ T   +    ++ +        +++ +  T   E         P  +TE  
Sbjct: 249  SLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVD 308

Query: 5676 KLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLY 5735
               D +Q A++ V                +  S E+ F+   D S  +  VK Q      
Sbjct: 309  MDLDSYQIALEEVLT--------------WLLSAEDTFQEQDDISDDVEEVKDQ------ 348

Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKES--VGRRISQLQDSWKD 5793
                  HE    E+     +++    L+AG +L+    L  +E   +  +++ L   W+ 
Sbjct: 349  ---FATHEAFMMEL--TAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403

Query: 5794 MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSEDPLPELHEDLHNEKELI 5851
            +  ++  M +Q +      +  +K++++L + L +   + Q  +  P L +D+ + ++L+
Sbjct: 404  L--RVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCP-LDDDVKSLQKLL 460

Query: 5852 KELEQSLASWTQNLKELQTMKADLTRHVLVED-------VMVLKEQIEHLHRQWEDLCLR 5904
            +E  +SL S   +L+  Q     LT  V++ D         +L++Q++ L  +W  +C  
Sbjct: 461  EE-HKSLQS---DLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRW 516

Query: 5905 VAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCM- 5960
               R   +++    W    E+   L AWL + E   NKV  +     +E+   +++  + 
Sbjct: 517  TEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAIL 576

Query: 5961 -EEINLFSENKLQLKQMGDQLIKASNKSRAA-EIDDKLNKINDRWQHLFDVIGSRVKKLK 6018
             E++ +  +   QL ++G  + +  + S+A+ +I+    ++  RW  L   +     ++ 
Sbjct: 577  KEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVT 636

Query: 6019 ETFAFI-----------------------------------------------QQLDKNM 6031
            +  A +                                               ++ D   
Sbjct: 637  QAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAIS 696

Query: 6032 SNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLL 6091
            + L  W+ + ++ +    + +    Q+  +   + + L+++  +     + +     +L+
Sbjct: 697  AELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756

Query: 6092 HDSDACANETECDSIQQTTRSLDRRWRNIC--AMSMERRMKIEETWRLWQKFLDDYSRF- 6148
                     TE   I+     +   W+N+      +ER+++++E    + K LD+  +  
Sbjct: 757  EQMGKEGLPTE--EIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVI 814

Query: 6149 ---EDWLKSAERTAACPNSSEVLYTSAKEEL 6176
               E+W+K    + +   S   L  S + EL
Sbjct: 815  KTKEEWVKHTSISESSRQSLPSLKDSCQREL 845



 Score = 44.7 bits (104), Expect = 0.003
 Identities = 237/1278 (18%), Positives = 484/1278 (37%), Gaps = 270/1278 (21%)

Query: 738  DVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQN 797
            D+EKL   +E      +  L+  D D  M+E       + +  +E++ R E+ML   +++
Sbjct: 1774 DLEKLENDIENMLKFVEKHLESSDEDEKMDE-------ESAQIEEVLQRGEEMLHQPMED 1826

Query: 798  ISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKEL 857
                                  KEK+++ ++ L      +  +      + KM +    +
Sbjct: 1827 --------------------NKKEKIRLQLLLLHTRYNKIKAIPIQ---QRKMGQLASGI 1863

Query: 858  ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
             S ++           P + + +  + L+  +   L+     V EL   + ED     E+
Sbjct: 1864 RSSLL-----------PTDYLVEINKILLCMDDVELSLN---VPELNTAIYEDFSFQ-ED 1908

Query: 918  KSRDVCAKWESLHHELS-LYVQQLKIDIEKG-----KLSDNILKLEKQINKEKKLI--RR 969
              +++  + + L  +++ ++ +Q  + +E       ++ D + +L  + ++  ++   R+
Sbjct: 1909 SLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRK 1968

Query: 970  GRTKGLIKEHEACFSEEGCLYQ-LNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
            G     ++E      +   L Q +    E+L + C   P      E  R+   ++Q++E 
Sbjct: 1969 GCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCA--PGGSLDLEKARI---HQQELEV 2023

Query: 1029 LLKCASEIHMTLQPTAGGT----SKNEGTITTSENRGGDPHSEAPFAK-SDNQPSTEKAM 1083
             +         L  T  G     S+ +G+    +  G +   +A  A+  D QP  +   
Sbjct: 2024 GISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGES 2083

Query: 1084 EPTMKF--SLASVLRPLQE-ESIMEKDYSASINSLLERYDTYRDILEHH------LQNNK 1134
            +  MK+   L  ++  L + E  M+K  +  +   L+        +E H      L   +
Sbjct: 2084 KQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTE 2143

Query: 1135 FRITSDFS---SEEDRSSSCLQAKLTDLQVIKNETDARWKEF-----EIISLKLENHVND 1186
              + SD S    E D+ S  L+        I  E     KE       +   ++  H N 
Sbjct: 2144 LEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNV 2203

Query: 1187 IKKPFVIKERDTLKERERELQMTLNTRMESLETALR----LVLPVEKASLLLCGSDLPLH 1242
             K   V    D   +  R  ++++   ++   T L     L+  + K++++  G    ++
Sbjct: 2204 QKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEIN 2263

Query: 1243 KMAIQGFHLIDAD------------RIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELH 1290
            K  +    +  AD             + Q+L+N   S   +  I  +LE   N      H
Sbjct: 2264 K-TVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQH 2322

Query: 1291 PFDLHAMQ--NIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348
              +L   Q  ++I+      +  +HR + +E+ ++  E  L  L+ A+   +P+T    S
Sbjct: 2323 GVELRQQQLEDMIID---SLQWDDHR-EETEELMRKYEARLYILQQAR--RDPLTK-QIS 2375

Query: 1349 DTQV-------------AQENTLTVKNKE---GEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
            D Q+             A +N L    +E    +   +K+  ++L      L  S  D +
Sbjct: 2376 DNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQ 2435

Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKN--------NELLKNIQ 1444
               +     +    S +  E     +QE  T  N L++A   +N         EL + +Q
Sbjct: 2436 NALEAEWRTV--QASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQ 2493

Query: 1445 DVQSQI--------SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPH 1496
            D+Q++I        S  G +   V A+ + +++ + L   LD+  +    L+  + S+  
Sbjct: 2494 DIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATM-LQHRLDDMNQRWNDLKAKSASIRA 2552

Query: 1497 FKDGREKTVNQQCQNT--VVLWENTKALVTECLEQC---GRVLELLKQYQNFKSILTTLI 1551
              +   +  N+   +   ++ W N K    E  +Q    G V  L  QY + K++   L 
Sbjct: 2553 HLEASAEKWNRLLMSLEELIKWLNMKD--EELKKQMPIGGDVPALQLQYDHCKALRRELK 2610

Query: 1552 QKEESVIS-------------LQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVC 1598
            +KE SV++             ++A    + NL+ +    E+  EE         +  ++ 
Sbjct: 2611 EKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKT---ELTPEE---------RAQKIA 2658

Query: 1599 KNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVI 1658
            K ++               K+++ + ++W  +N  T ++ + + +AL   +KL +L+  +
Sbjct: 2659 KAMR---------------KQSSEVKEKWESLNAVTSNWQKQVDKAL---EKLRDLQGAM 2700

Query: 1659 DEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQ-----SSEI- 1712
            D+      +   +    +   + L + LQ H +K   F   +A I F ++     SS++ 
Sbjct: 2701 DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLS 2760

Query: 1713 PLEL-----------------QVMESSILNKMEHVQKCLT--GESNCHALSGST------ 1747
            PL+L                 ++++ S+ ++++ +Q+     G S+ H LS S       
Sbjct: 2761 PLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQR 2820

Query: 1748 -------------------------AELRE---DLDQAKTQIGMTESLLKALSPS---DS 1776
                                      EL +   DL+  +     T   ++ L  +   D 
Sbjct: 2821 SISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDL 2880

Query: 1777 LEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHF 1836
            LE+ T  E  +Q  L Q   ++ + + I CLT     L++ ++   DL N    V     
Sbjct: 2881 LELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHK---DLVNVPLCV----- 2932

Query: 1837 SKLLNDQCKNFNDWFSNI 1854
                 D C N   W  N+
Sbjct: 2933 -----DMCLN---WLLNV 2942



 Score = 43.9 bits (102), Expect = 0.006
 Identities = 38/179 (21%), Positives = 83/179 (46%), Gaps = 5/179 (2%)

Query: 6554 QQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSV 6613
            +Q + D++ +T W+  TEAE  ++    P   +   + R+ + QE+     +++    ++
Sbjct: 1979 RQFHCDLNDLTQWI--TEAEELLVDTCAPGGSLDLEKARIHQ-QELEVGISSHQPSFAAL 2035

Query: 6614 NVSSKEFLQTESP-ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQN 6672
            N +    +Q  S  + + L+ +L  L+  W+A    V   +  L+    Q   +      
Sbjct: 2036 NRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDE 2095

Query: 6673 LLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLEKELVERQPQVDMLQEISNSL 6730
            ++ WL  A++  QK   T+   + + L +  +E+ +  EK     + +++ML + S SL
Sbjct: 2096 IICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSL 2154



 Score = 37.7 bits (86), Expect = 0.40
 Identities = 51/256 (19%), Positives = 107/256 (41%), Gaps = 22/256 (8%)

Query: 6515 QQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTE 6571
            +Q+     G+ EQ +     +  + AQ    K  +++  Q   ++  + ++++ WL  TE
Sbjct: 1505 KQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564

Query: 6572 AELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTEL 6631
             EL  ++ +     + +++  +   + +LK  +  KA + ++  SS             L
Sbjct: 1565 TEL--VQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPIL 1622

Query: 6632 QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTD 6691
            + RL  L+  W   +   + W   L     Q + F     ++  WL  A     +A + +
Sbjct: 1623 EERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQA-----EALLDE 1677

Query: 6692 PKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEK 6751
             +  P +  E    + +L  EL +   QV+ +++    +L+   G    E      ++E 
Sbjct: 1678 IEKKPTSKQE--EIVKRLVSELDDANLQVENVRD-QALILMNARGSSSRE------LVEP 1728

Query: 6752 KLKQLR---EQVSQDL 6764
            KL +L    E+VSQ +
Sbjct: 1729 KLAELNRNFEKVSQHI 1744



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 28/149 (18%), Positives = 58/149 (38%), Gaps = 3/149 (2%)

Query: 6621 LQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
            L+   PE+ +++  L QL+  W+         +G   +++ + + FH    +L  W+  A
Sbjct: 1936 LEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEA 1995

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6740
            +             D   L + R    +LE  +   QP    L    + ++ K    D  
Sbjct: 1996 EELLVDTCAPGGSLD---LEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGS 2052

Query: 6741 EAEEKVHVIEKKLKQLREQVSQDLMALQG 6769
              +EK+  + ++   +  +V      L+G
Sbjct: 2053 FLKEKLAGLNQRWDAIVAEVKDRQPRLKG 2081


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  212 bits (539), Expect = 1e-53
 Identities = 672/3714 (18%), Positives = 1448/3714 (38%), Gaps = 480/3714 (12%)

Query: 2856 LIIPRVETAATEAELKHHHVT--LEASQKELQEIDSGISTHLQ---ELTNIYEELNVFER 2910
            L + R +   ++ + + H V   LE  Q EL+ I   +  +      L    EE    + 
Sbjct: 1240 LDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQE 1299

Query: 2911 LFLEDQLKNLKIRTNRIQR----FIQNTCNEVEHKIKFCRQFHEKTSALQE--EADSIQR 2964
            +    Q ++ ++ + ++ +    F +   N+   K+  C++F ++ S + +  E   +  
Sbjct: 1300 MMKPGQAEDSRVLSEQLSQQTALFAEIERNQT--KLDQCQKFSQQYSTIVKDYELQLMTY 1357

Query: 2965 NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQ- 3023
               + +Q+ + G +  + +  D +T                +++ L   ++ L  L TQ 
Sbjct: 1358 KAFVESQQKSPGKRRRMLSSSDAITQ---------------EFMDLRTRYTALVTLTTQH 1402

Query: 3024 ---VFEKEKELEEKIKQLDTFEEEH-GKYQALLSKMRAIDLQIKKMTEVVLKAPDS-SPE 3078
               + +  + LEE+ K ++  ++EH  K + LL  +  +    +       KA  S + E
Sbjct: 1403 VKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQG------KATSSETKE 1456

Query: 3079 SRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQ 3138
            S  +   IL Q++     L +E+  K  +     ++ K  +I   K   + ++K  K + 
Sbjct: 1457 STDIEKAILEQQV-----LSEELTTKKEQ---VSEAIKTSQIFLAKHGHKLSEKEKKQIS 1508

Query: 3139 NMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQ 3198
              +  L+      K   D  + S + L Q++SQL        E K +Q +++ C    E 
Sbjct: 1509 EQLNALN------KAYHDLCDGSANQLQQLQSQLAH----QTEQKTLQKQQNTCHQQLED 1558

Query: 3199 V--WAEMC-----------SIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSID 3245
            +  W               + + ++A++K + +      D++ +   F  +   +   ++
Sbjct: 1559 LCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME 1618

Query: 3246 LRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELES 3305
                 L+     LT  +E + +A E   +L+      RV     EE++   L+++ E   
Sbjct: 1619 ENQTKLSP--RELTALREKLHQAKEQYEALQE---ETRVAQKELEEAVTSALQQETEKSK 1673

Query: 3306 TVAHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN 3360
                + +  +K+  +     S   +  QL   L  +   + A  E      T+   Y+  
Sbjct: 1674 AAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG--YMGV 1731

Query: 3361 YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL 3420
             +   K+++      ++ + +L Q  + + L+ + A   L+Q      NL  T EE   L
Sbjct: 1732 NQAPEKLDKQCEMMKARHQELLSQQQNFI-LATQSAQAFLDQHG---HNL--TPEEQQML 1785

Query: 3421 RQILRLLRLRCTEN--DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEI 3478
            +Q L  L+ + + +       LK V  L ++    L+  KE+E W E  ++E        
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE-------- 1837

Query: 3479 EREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ---LLLTLLLQRI 3535
                  L+N+          K  ++ E L  LL     + E+V   +     +T+  Q++
Sbjct: 1838 ------LENMH---------KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV 1882

Query: 3536 RSIQNVPESSGAVETVPAF--QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEII 3593
              ++N  +       +      ++    ER   L  K  +    +   + + H F     
Sbjct: 1883 LDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSAD 1942

Query: 3594 ALKNFFQQTTTSFQNM----AFQDHPEKSEQF---EELQSILKKGKLTFENIMEKLRIKY 3646
            +L+ + Q    + + +       D     EQ    ++LQ  L + ++  E + +  R   
Sbjct: 1943 SLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--- 1999

Query: 3647 SEMYTIV--PAEIESQVEECRKALEDIDEKISNEVLKSSP--------SYAMRRKIEEIN 3696
             ++  I   PA     V+E   ++    + +S  + + S         S +++  +E + 
Sbjct: 2000 -DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058

Query: 3697 NGLHNVEKMLQQKSKN------IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQ-DP 3749
              +  VE+ L+ K  +      I++A     K+  ++    S L      V   +E  D 
Sbjct: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118

Query: 3750 GQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLA 3809
              A      L    Q+++Q+  + + + S L K   + E +  L    + ++EN S +LA
Sbjct: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2178

Query: 3810 NPADYDSLRTLSHHASTVQ---MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQE 3866
            +    D  + ++H    +Q   + +ED ++  + L  +  +L       +  +    +Q 
Sbjct: 2179 SGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236

Query: 3867 LSNQVTALQQKIME---SLPQIQRMADD----VVAIESEVKSMEKRVSKIKTILLSKEIF 3919
            L    T LQ+ + E        Q   D+    V   +  +K  E  +   +T + +KE+ 
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL- 2295

Query: 3920 DFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELR------------------LPQTGM 3961
                E+ ++H + +L++       + EI      L                   LP  G 
Sbjct: 2296 ----EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS 2351

Query: 3962 KPLPV--FQRTNQL------LQDIKL----LENVTQEQNELLKVVIKQTNEWDEEIENLK 4009
                V  +     L      + D+ L    L  V  E+ E L+ ++ +  E  +E  ++ 
Sbjct: 2352 SVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVL 2411

Query: 4010 QILNNYSAQF-SLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLH 4068
            Q L +      S++ MS     +  + Q E  +     L  N  K   + +  A +L  +
Sbjct: 2412 QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2471

Query: 4069 QHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDN 4128
             +  QE E  ++ +    +  E       A +R+L    S S+LA  +            
Sbjct: 2472 PN-SQEAENWKKIQEELNSRWERATEVTVARQRQLEE--SASHLACFQA----------- 2517

Query: 4129 GDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNT 4188
                AE   + W         ME++      G +  +    +  +     Q +  +    
Sbjct: 2518 ----AESQLRPWL--------MEKELMMGVLGPLSIDP--NMLNAQKQQVQFMLKEFEAR 2563

Query: 4189 EQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAEL 4248
             Q  E   + N+  +G        +L +S  Q  L+  + +   E T+ L++  +Q+ + 
Sbjct: 2564 RQQHE---QLNEAAQGILTGPGDVSLSTSQVQKELQS-INQKWVELTDKLNSRSSQIDQ- 2618

Query: 4249 ELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGAT 4308
                     A+   T   ++ Q L +++      L+ ++  ++   E  K Q L +    
Sbjct: 2619 ---------AIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPEAVKQQ-LEETSEI 2667

Query: 4309 QHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEP-EHQEALQPVNLSELE 4367
            + + E L  ++K  +   +++ +++ E++ +D+    L+  + P +  E L    ++ L+
Sbjct: 2668 RSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727

Query: 4368 SIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSAS 4427
            + +    QF +  D + +  L+ K  +Q    K    +AK    Q    +N+  Q+S  +
Sbjct: 2728 AALASTQQFQQMFD-ELRTWLDDKQSQQA---KNCPISAKLERLQSQLQENEEFQKS-LN 2782

Query: 4428 NQASSPENDVPDS---ILS-PQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILP 4483
              + S E  V +    +LS P G+     Q    EL +  +  L +    + S     + 
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWE-ELSKKTADRQSRLKDCMQ 2841

Query: 4484 SVTMYNFRY----PTTEELKTYTTQL----EDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
                Y +      P  E+ K   ++L    + ++ E+S L+++  + E   +   + L E
Sbjct: 2842 KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE---VEKRRSLLE 2898

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK----GDLLK 4591
            +  + +  L +  E  E      + G  Q +   T  L+ K   L    ++     +  K
Sbjct: 2899 ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFK 2958

Query: 4592 AMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIK 4651
             +    E     LE FD L         +  C +K+L+      R+ Q  ++ L  Q+  
Sbjct: 2959 NIEKKVEGAKHQLEIFDAL--------GSQACSNKNLEK----LRAQQEVLQALEPQVDY 3006

Query: 4652 SKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYK 4711
             +   Q  + +    S A QL         L  AE    +  +  +R++    +++   K
Sbjct: 3007 LRNFTQGLVEDAPDGSDASQL---------LHQAEVAQQEFLEVKQRVNSGCVMMEN--K 3055

Query: 4712 LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVA 4771
            LE +     G    R  E+ S     +  D  L GM     IG++              +
Sbjct: 3056 LEGI-----GQFHCRVREMFSQL---ADLDDELDGMGA---IGRDT------------DS 3092

Query: 4772 LQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGM 4831
            LQ+QIE+ ++F  K+    L I+A  A+    L    E    + +   + LE  ++QCG 
Sbjct: 3093 LQSQIEDVRLFLNKIHVLKLDIEASEAECRHML---EEEGTLDLLGLKRELEALNKQCGK 3149

Query: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETE----------ERLVERISFY 4881
              +    + E+ +     +E     L     + +  EE E          E + ++++ +
Sbjct: 3150 LTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADF 3209

Query: 4882 QQI-KRNIGGKHARLYQTLNEGKQLVASVS----CPELEGQIAKLEEQWLSLNKKIDHEL 4936
            +   K  +     +L Q    G+ L+ S         LE  + ++  +W +LNKK+   +
Sbjct: 3210 KMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRI 3269

Query: 4937 HRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSK 4996
             +LQ  L H   +    + L  WL  ++  +   K  S     +   +++ I       +
Sbjct: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQR 3325

Query: 4997 EVDEKSSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
             +D++ +    + + G ++    E  D   +   L   E +WT L+++    Q++L  + 
Sbjct: 3326 LLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3385

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
            +      +    +  +++  E + ++ + V + ++  +++  + +HK   +E D +    
Sbjct: 3386 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA--KIQQQIIRHKA--LEEDIENHAT 3441

Query: 5116 DFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE- 5174
            D V+Q++    +    +   E+   +E +  +  ++  +     RK   L+Q L +    
Sbjct: 3442 D-VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLF 3500

Query: 5175 SENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYL 5234
             E+++++LN WL   E++L ++     V   ++ +L  Q  ++ LA+  + ++  K    
Sbjct: 3501 GEDEVEVLN-WLAEVEDKLSSV----FVKDFKQDVLHRQHADH-LALNEEIVNRKKNVDQ 3554

Query: 5235 TLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQL-------YD 5287
             +++G   L + T   +  + +K   + T+   +  +    L+  +   QL       Y+
Sbjct: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614

Query: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
            E+          +  S     + E +    +  + L+ E        + + EV   L  L
Sbjct: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL 3674

Query: 5348 CPSVA-EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEA 5406
             P  A E +++   + ++++  V+  I  ++ +  + +Q  + Y  A     A + + + 
Sbjct: 3675 VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKR 3734

Query: 5407 KFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTK----EAFLQNSSVLDRLPQPAES 5462
            K   L  I +  +         LQ  K    D+ + K    E F   S +     +  ++
Sbjct: 3735 KLMALGPIRLEQDQTTA----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKT 3790

Query: 5463 STHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF----KDFGVRLESLKGLIMH--- 5515
                     +   +  + L      +    + +++QF    ++    +E  + LI     
Sbjct: 3791 VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPS 3850

Query: 5516 ---EEENLDRLHQQEKENPDSFLNH---VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ 5569
               + E L +  ++ ++  +S   H   +  L    P ++ LN    ++   +   +  +
Sbjct: 3851 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV--EEKYQKAE 3908

Query: 5570 NMNRQW---IRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPE 5626
            NM  Q    +R  A AL+     Q   + E             +KIE  L+     +L  
Sbjct: 3909 NMYAQIKEEVRQRALALDEAVS-QSTQITE-----------FHDKIEPMLE-----TLEN 3951

Query: 5627 LLEQQKTYKMLEAEVS-INQTIADSY-VTQSLQLLDTT--EIENRPEFITEFSKLTDRWQ 5682
            L  + +   ++ AEV  I + I+D+   T  L+ L  +   ++ R E +   S+  D+  
Sbjct: 3952 LSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDL 4011

Query: 5683 NAVQGVRQRKGDVDGLVRQWQD-----------FTTSVENLFRFLTDTSHLLSAVKGQER 5731
             A    ++ +  +D +V  W+D           F   +E   +F  D + LL+ +K    
Sbjct: 4012 AA----KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK---- 4063

Query: 5732 FSLYQTRSLIHELKNKEIH--FQRRRTTCALTLEA---------------GEKLLLTTDL 5774
                 T+ ++H+L++  I     +++   A T++                G  L+     
Sbjct: 4064 ----DTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4119

Query: 5775 KTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQ--VLKAQ 5832
              K  V + I ++ ++W+++     E +++ +  ++   Q +  ++ +   L   V+K  
Sbjct: 4120 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4179

Query: 5833 SEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD----LTRHVLVEDVMVLK 5888
            +   +P +  DL+  K+ + E+++      Q   E++ +       L +     D  +++
Sbjct: 4180 T---MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIR 4236

Query: 5889 EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI 5948
            E +  L   WE+L  ++A R+ ++E  L     F    +EL +WL   E  +     IS 
Sbjct: 4237 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4296

Query: 5949 EEMI---EKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQ 6004
            +  +   E  +   ++   L  +  ++ + + G++L+++S    A+ +  +L  +N  W+
Sbjct: 4297 DPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWE 4356

Query: 6005 HLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKR 6062
             +      R ++L+ T    Q     + +    L R+ES+LS  KP          + + 
Sbjct: 4357 SVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT-------GGLPET 4409

Query: 6063 LAEQQDLQRDIEQHSAGVESVFN-ICD-----VLLHDSDACANETECDSIQQTTRSLDRR 6116
              EQ D   ++       E  +N + D     +L  D     ++TE     Q+   L+++
Sbjct: 4410 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE-----QSVALLEQK 4464

Query: 6117 WRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEEL 6176
            W  + +   ER+ K+EE   L  +F +    F +WL  AE++    +   ++  +   ++
Sbjct: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 4524

Query: 6177 KRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAV 6236
            +  + F  +++    Q+  +++   +L   ++      +K ++     RW+ + +R    
Sbjct: 4525 EEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER 4584

Query: 6237 LRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLN---GFQQEI 6293
             R L     + ++F    + ++ WL + +  L +    S +D D    QL+    FQ+ +
Sbjct: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTL 4643

Query: 6294 TLNTNKIDQLIVFGEQLIQKS-EPLDAVLIEDELEELHRYCQEVFGR-VSRFHR 6345
                   D  I  G  L +K+  P D+  +++ L E+      V G+ V R H+
Sbjct: 4644 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 4697



 Score =  205 bits (521), Expect = 1e-51
 Identities = 147/439 (33%), Positives = 215/439 (48%), Gaps = 79/439 (17%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT W+N  L +      I+DL+ D++ GH L+ LLEVLSG +LPR+KG   
Sbjct: 75  ERDRVQKKTFTKWVNKHLMKVRKH--INDLYEDLRDGHNLISLLEVLSGIKLPREKGRMR 132

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL FL+ R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 133 FHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--------- 183

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ +   S                  MSA++ LLLW Q+  A Y  +  T+F 
Sbjct: 184 -------DIYISGESG----------------DMSAKEKLLLWTQKVTAGYTGIKCTNFS 220

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           S W +G  F A+IH  RPDL+DM+ V+ +SN++NL +AF +AE+ L + RLL+ EDVDV 
Sbjct: 221 SCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVP 279

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGE------------EAQGKVKDAMGWLTLQKEKLQK 315
            PDEKS++TYV+         P  GE            E Q +V   + W+  Q   L  
Sbjct: 280 SPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIK-QHTILMS 338

Query: 316 LLKDSENDTYFKK-YNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAWDGLD 374
                +N    K  YN  + F E+         ++L+ +R+   +++ + +L E W    
Sbjct: 339 DKTFPQNPVELKALYNQYIHFKET---------EILAKEREKGRIEELY-KLLEVW---- 384

Query: 375 HQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQ---------- 424
             I   +IKL     P     E W + + E+++ + S      +   L+Q          
Sbjct: 385 --IEFGRIKLPQGYHPN-DVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGAL 441

Query: 425 ---EKMTLFKSLMDRFEHH 440
              EK+TL K+ +     H
Sbjct: 442 NCEEKLTLAKNTLQADAAH 460



 Score =  194 bits (493), Expect = 3e-48
 Identities = 338/1738 (19%), Positives = 664/1738 (38%), Gaps = 205/1738 (11%)

Query: 4740 QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ-----KLVADMLLIQ 4794
            QDAL + ++  +   +E +A+      + KV ++AQI+  K+  +     K   DML  +
Sbjct: 3283 QDAL-EPLLSWLADTEELIANQKPPSAEYKV-VKAQIQEQKLLQRLLDDRKATVDMLQAE 3340

Query: 4795 ----AYSAKI-----LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDE 4845
                A SA++     +   L++ E+ W E +++    +++       L+ +L   ++F E
Sbjct: 3341 GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ-------LEDILVLAKQFHE 3393

Query: 4846 NYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQL 4905
                +   L +    L +   V     ++ ++I  ++ ++ +I      ++Q +  G+ L
Sbjct: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453

Query: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS----YNRDSDQLTKWLE 4961
             +S++ P  +G +++  +   +   +I     R  ALL   LS    +  D  ++  WL 
Sbjct: 3454 -SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLA 3512

Query: 4962 SSQHTLNYWKEQSLNVSQ-DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
              +  L+     S+ V     D +     +    ++E+  +       I  G  LL  K+
Sbjct: 3513 EVEDKLS-----SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL--KQ 3565

Query: 5021 T---DTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEH 5077
            T   +   ++  L   + ++  +          L Q +      +    E+  W+  VE 
Sbjct: 3566 TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE 3625

Query: 5078 QTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYER 5137
            + +      SP+   Q+    Q+ KE + E+   + ++D VN+    +S   +E   +  
Sbjct: 3626 ELATSGG-QSPTG-EQIPQFQQRQKELKKEVMEHRLVLDTVNE----VSRALLELVPWRA 3679

Query: 5138 TEFAEHL-GEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL 5196
             E  + L  + N Q+  V   + +++  ++  ++   + E        W+   + +L  L
Sbjct: 3680 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 3739

Query: 5197 QKPESVISVQKLLLDCQDIENQLAI-KSKALDELKQSYLTLESGAVPLLEDTASRIDELF 5255
                       + L+      QL + K+ ++D ++                    +DELF
Sbjct: 3740 GP---------IRLEQDQTTAQLQVQKAFSIDIIRHK----------------DSMDELF 3774

Query: 5256 QKRSSVL-----TQVNQLKTSMQSVLQEWKIYDQLYDE-------VNMMTIRFWYCMEHS 5303
              RS +       Q   L+   +S++Q+++    L  E         ++  +FW   E  
Sbjct: 3775 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 3834

Query: 5304 KPVV--------------LSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCP 5349
             P +              +  E LR Q E ++ L++     +   +KL ++  +LK L P
Sbjct: 3835 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP 3894

Query: 5350 SVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQ 5409
               E++EEK Q     + Q+ + +  +       +      +  H +        E   +
Sbjct: 3895 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKI-------EPMLE 3947

Query: 5410 QLANISMSGNNLAEILPPALQDIKELQHD----------VQKTKEAFLQNSSVLDRLPQP 5459
             L N+S S   +  ++P  +  I+E   D          +Q + EA  +    L    Q 
Sbjct: 3948 TLENLS-SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006

Query: 5460 AESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL-ESLKGLIMHEEE 5518
            A+    +        L +  +  + +  +A E E       +   +    +  L+   ++
Sbjct: 4007 ADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064

Query: 5519 NLDRLHQQEKE--NPDSFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAV--------- 5565
              D +H  E    +P      V A      + + L+E    +++  +D+           
Sbjct: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124

Query: 5566 --KTLQNMNRQWIRATATALERCSEL----QGIGLNEKFLYCCEKWIQLLEKIEEALKVD 5619
              K++  MN  W     T  ER  +L    Q     +  L     W+     I+      
Sbjct: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPP 4183

Query: 5620 VANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE-FSKLT 5678
            V   L  + +Q    K  + EV   Q   +    Q   +L     E   + I E  ++L 
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELK 4243

Query: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSA---VKGQERFSLY 5735
              W+N  + +  R+  ++G +     F  ++E L  +LT T  LL A   + G  +    
Sbjct: 4244 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEV 4303

Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
            +     H LKN  +  Q    T     +AG +LL ++      S+  R+  +   W+ + 
Sbjct: 4304 ELAKH-HVLKNDVLAHQ---ATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359

Query: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ--SEDP---LPEL-HEDLHNEKE 5849
             +  E  +Q QST++       +I++    L  +++Q  +  P   LPE   E L    E
Sbjct: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4419

Query: 5850 LIKELEQSLASWTQNLKELQTM---KADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
            L  +L+    ++ Q L + + M   + D       E  + L EQ      +W  +  ++ 
Sbjct: 4420 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKME 4473

Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK---------VLQTADISIEEMIEKLQK 5957
             RK ++E+ LN    F    +E   WL   E           +L T    IEE      K
Sbjct: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE-----HK 4528

Query: 5958 DCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
                E+N   +  ++L Q G+QL   S K     I + L  +  RW+ +      R + L
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588

Query: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
             +     +Q  +    L  WL   ES L   +     D  +I+ +L++ ++ Q+ +    
Sbjct: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN-DPDKIKLQLSKHKEFQKTL---- 4643

Query: 6078 AGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR-------RWRNICAMSMERRMK 6130
             G + V+   D  +    A   +T    + + ++ LD        +W  +C  S+ER+ K
Sbjct: 4644 GGKQPVY---DTTIRTGRALKEKT---LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 4697

Query: 6131 IEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERL 6190
            +EE      +F+D      DWL   E   A               +   + FQ+++ +R 
Sbjct: 4698 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 4757

Query: 6191 TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEF 6250
              ++++ +  R L   +R DT + +K  + E + RWD + +   +   RL     Q E F
Sbjct: 4758 GTVQVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF 4816

Query: 6251 EGTRESILVWLTEMDLQLTNVEHFSESDADD--KMRQL----NGFQQEITLNTNKIDQLI 6304
              T   +L WL+E +  L     F  +  DD   ++ L      F +++      ++  +
Sbjct: 4817 RDTVHMLLEWLSEAEQTL----RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAV 4872

Query: 6305 VFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASE 6362
              GE ++    P     I+  +  +    +EV     +  +RL +    L    E  E
Sbjct: 4873 AMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE 4930



 Score =  192 bits (488), Expect = 1e-47
 Identities = 675/3678 (18%), Positives = 1403/3678 (38%), Gaps = 555/3678 (15%)

Query: 2883 ELQEIDSGISTHLQELTNIYEE---LNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE-- 2937
            E  +I   +  H ++      +    +V +RL LE++++  K R   + + ++N   E  
Sbjct: 985  ECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEET 1044

Query: 2938 ----------------VEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEI 2981
                             E++ +  ++     S+ + + D+ Q N L + ++  +  +E++
Sbjct: 1045 VAKMYISELKNIRLRLEEYEQRVVKRIQSLASS-RTDRDAWQDNALRIAEQ--EHTQEDL 1101

Query: 2982 YNLKDRLTAIKCCILQVLKLKKVFDYI-----GLNWDFSQLDQ---LQTQVFEKEKELEE 3033
              L+  L A+       L        +      LN    ++D    L T    K K ++ 
Sbjct: 1102 QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDV 1161

Query: 3034 KIKQLDTFEEEHGKYQALLSKMRAI--DLQIKKMTEVVLKAPDSSPESRRLNAQILSQRI 3091
             ++ +   E     Y+  LS+   +  DL   +     L+   S  + +     +L + I
Sbjct: 1162 IVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEI 1221

Query: 3092 EKAKCLCDEIIKKLNENKTFDDSFKEK----------EILQIKLNAEENDKLYKVL--QN 3139
             KAK + +++ +   E     + ++EK           I Q+++   E + + +VL    
Sbjct: 1222 AKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYR 1281

Query: 3140 MVLELSPKELDEKNCQDKLETSLHVLNQ--IKSQLQQPLLINLEIKHIQNEKDNCEAFQE 3197
                   K ++E   Q ++       +   +  QL Q   +  EI+  Q + D C+ F +
Sbjct: 1282 ACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQ 1341

Query: 3198 QVWA-------EMCSIKA-VTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRT- 3248
            Q          ++ + KA V + +K   +     S  +   +EF DL+ +    + L T 
Sbjct: 1342 QYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQ 1401

Query: 3249 --NVLNDAYENLTRYKEAVTRA----VESITSLEAIIIPYRVDVGNPEESLEMPLRKQEE 3302
                ++DA   L   ++ V       VE +  L   +     +      S E   ++  +
Sbjct: 1402 HVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSE--TKESTD 1459

Query: 3303 LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNS-AMKEAFKAQETEAERYLENY 3361
            +E  +   Q L+E+L   +  E   +   T Q  ++K+   + E  K Q +E    L   
Sbjct: 1460 IEKAILEQQVLSEEL--TTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN-- 1515

Query: 3362 KCYRKMEEDIYTNLSKMETVLGQSMSSLPL-----SYREALERL-------------EQS 3403
            K Y  + +     L ++++ L        L     +  + LE L              Q 
Sbjct: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575

Query: 3404 KALVSNLISTKEELMKLRQILRLLRLRCT--------------ENDGICLLKIVSALWEK 3449
            +    +L + ++    L+ +   ++ R T              EN      + ++AL EK
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635

Query: 3450 WLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSE 3509
                L  AKE     E L++E +   +E+E    +   LQ+   E  K+K A    E  +
Sbjct: 1636 ----LHQAKE---QYEALQEETRVAQKELEE--AVTSALQQ---ETEKSKAAKELAENKK 1683

Query: 3510 LLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQ 3569
             +D L  +  +V      L   L  +  +       GA++T   +  +       N+  +
Sbjct: 1684 KIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGV-------NQAPE 1736

Query: 3570 KVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILK 3629
            K+ K  E+++     RH   +E+++ +  F   T S Q  AF D    +   EE Q + +
Sbjct: 1737 KLDKQCEMMKA----RH---QELLSQQQNFILATQSAQ--AFLDQHGHNLTPEEQQMLQQ 1787

Query: 3630 K-GKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAM 3688
            K G+L              E Y+   A+ E+++++ +   +++ + + +     S     
Sbjct: 1788 KLGEL-------------KEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERS 1834

Query: 3689 RRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQD 3748
             +++E ++ G  + E +     +    ++++     D   +  S    LD E      ++
Sbjct: 1835 EKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 1894

Query: 3749 PGQAQEWM-DNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIE----N 3803
            P +    + D L    ++Y  +  +     S LN    +  ++ +   S +AW++    N
Sbjct: 1895 PSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEAN 1954

Query: 3804 TSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL--LHSIFMDLEDLS--------- 3852
               LL++    D        A+T Q+  E +E +  +  L  +  D+ ++          
Sbjct: 1955 VEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRH 2014

Query: 3853 IIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTI 3912
            +   TD +    Q LS  +      + +++ Q Q + + + ++   +  +E+ +   +  
Sbjct: 2015 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS 2074

Query: 3913 LLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQ 3972
             LS  +   +   ++K  + I      ++ T  E+V+  +E     T           +Q
Sbjct: 2075 SLSSGVIQEALATNMKLKQDIARQKSSLEAT-REMVTRFMETADSTTAAVLQGKLAEVSQ 2133

Query: 3973 LLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQ---- 4028
              + + L +   QE+   LK ++ Q   ++     L+Q + N S   +  +  PDQ    
Sbjct: 2134 RFEQLCLQQ---QEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN-QPDQDITH 2189

Query: 4029 -ADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKAT--VLNLHQHLKQEQ----EGVERD 4081
               ++ +L  E+E  ++ + +L    E L+ +L +    L+L QH  + Q    +  E  
Sbjct: 2190 FFQQIQELNLEMEDQQENLDTL----EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ 2245

Query: 4082 RLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEV--EESSVKSDNGDEKAEPSPQS 4139
            +      ++    +    E +   R    +L   E  +   E+S+ +   +++ E     
Sbjct: 2246 KTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE----- 2300

Query: 4140 WSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPN 4199
                  H K + +D A  S GT+V+E   K ++ +N + +I  PDS              
Sbjct: 2301 ------HLKSLLDDWA--SKGTLVEEINCKGTSLENLIMEITAPDS-------------- 2338

Query: 4200 QTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAV 4259
            Q + G+  P    ++ S +                    H CK  + E++  +   N+  
Sbjct: 2339 QGKTGSILPSVGSSVGSVNG------------------YHTCK-DLTEIQCDMSDVNLKY 2379

Query: 4260 EPETLNADMQQVLEQQLVGCQAMLTEIE--HKVA-FLLETCKDQGLGDNGATQHEAEALS 4316
            E       +  VL ++    QA+L  +E  HK A  +L+  + +   +      +A +  
Sbjct: 2380 E------KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSP 2430

Query: 4317 LKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKS--------SEPEHQEALQPVNLSELES 4368
             K +TVK   E  +  L E   E   P I K          + P  QEA    N  +++ 
Sbjct: 2431 TKTETVKAQAESNKAFLAE--LEQNSPKIQKVKEALAGLLVTYPNSQEA---ENWKKIQE 2485

Query: 4369 IVTERPQFSRQKDFQQQQVLE---------------LKP-MEQKDFIKFI---------E 4403
             +  R + + +    +Q+ LE               L+P + +K+ +  +          
Sbjct: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM 2545

Query: 4404 FNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKI 4463
             NA+K   Q+        +E  A  Q     N+    IL+  G                +
Sbjct: 2546 LNAQKQQVQF------MLKEFEARRQQHEQLNEAAQGILTGPGD---------------V 2584

Query: 4464 KLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEAS---------- 4513
             L   Q+ +   S N   +      N R    ++    +TQ ++L Q+ S          
Sbjct: 2585 SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 2644

Query: 4514 NLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEML----EMPRLYREDGSGQQV--H 4567
            ++Q+  +   EA     ++  E+   L Q    V+E      E+  L  E     ++   
Sbjct: 2645 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 2704

Query: 4568 YETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKS 4627
             ET+AL L+ L    +D+   L  A+     +T    + FD L+  L+  Q      S+ 
Sbjct: 2705 LETVALPLQGLEDLAADRINRLQAALA----STQQFQQMFDELRTWLDDKQ------SQQ 2754

Query: 4628 LKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAES 4687
             K     N     +++RL  QL +     Q+SLN+ SG           +Y V +   ES
Sbjct: 2755 AK-----NCPISAKLERLQSQL-QENEEFQKSLNQHSG-----------SYEVIVAEGES 2797

Query: 4688 RVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGM 4747
             +  +    E+      L  ++ +L++  + +      R + L        +    ++ +
Sbjct: 2798 LLLSVPPGEEK----RTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 2853

Query: 4748 VELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV--ADMLLIQAYSAKILPSLL 4805
            V  ++  K K++   L+ T   V L++ +   K    ++     +L I   +A IL +  
Sbjct: 2854 VPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 2911

Query: 4806 QNRETFWAEQVTEVK-----ILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLE----- 4855
            +  E    ++   +      + EE   + G  L+ + Q+  EF E++ ++EK +E     
Sbjct: 2912 EADEDGIRDEKAGINQNMDAVTEELQAKTG-SLEEMTQRLREFQESFKNIEKKVEGAKHQ 2970

Query: 4856 -ILISTLPSVSLVEETEERLVERISFYQQIKRNI----------------GGKHARL--- 4895
              +   L S +   +  E+L  +    Q ++  +                G   ++L   
Sbjct: 2971 LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQ 3030

Query: 4896 ----YQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNR 4951
                 Q   E KQ V S  C  +E ++  +  Q+    +++  +L  L   L  + +  R
Sbjct: 3031 AEVAQQEFLEVKQRVNS-GCVMMENKLEGI-GQFHCRVREMFSQLADLDDELDGMGAIGR 3088

Query: 4952 DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISI 5011
            D+D L   +E  +  LN      L    D++   +   +  E    +D    LK  + ++
Sbjct: 3089 DTDSLQSQIEDVRLFLNKIHVLKL----DIEASEAECRHMLEEEGTLD-LLGLKRELEAL 3143

Query: 5012 GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW 5071
              Q   L E   A         +++  + + ++ D   KL  L      + +A  E + W
Sbjct: 3144 NKQCGKLTERGKAR--------QEQLELTLGRVEDFYRKLKGLNDATTAAEEA--EALQW 3193

Query: 5072 MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLS--TCD 5129
            +   E +  ++              + QK +   ++M  +Q  V+ + Q L+Q +   CD
Sbjct: 3194 VVGTEVEIINQQLADF--------KMFQKEQVDPLQMKLQQ--VNGLGQGLIQSAGKDCD 3243

Query: 5130 VESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQ 5189
            V+   ++       + E+N +W+ ++  + ++I  L++ L    + ++ ++ L +WL   
Sbjct: 3244 VQGLEHD-------MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADT 3296

Query: 5190 EERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTAS 5249
            EE +   + P +   V K  +  Q +  +L    KA  ++ Q+    E G +    + A 
Sbjct: 3297 EELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQA----EGGRIAQSAELAD 3352

Query: 5250 R------IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHS 5303
            R      ++ L  + + +L++    +  ++ +L   K + +  + ++         + +S
Sbjct: 3353 REKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS 3412

Query: 5304 KPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL-CPSVAEIIEEKCQNT 5362
            +PV      ++ Q+   ++L+++ E+      +  ++   L  L  P+   ++ EK  + 
Sbjct: 3413 EPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSL 3472

Query: 5363 HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH--GEAAARLKQQEAKFQQLANISMSGNN 5420
              R+++    I D+  +  +LL   +A SNA   GE    +    A+ +   +     + 
Sbjct: 3473 QARYSE----IQDRCCRKAALLD--QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 3526

Query: 5421 LAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAY 5480
              ++L     D   L  ++   K+   Q       L +       +L+   L  + +  Y
Sbjct: 3527 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-KTRY 3585

Query: 5481 LEKMLLVKANEFEFVLSQFKDFGVRLES----LKGLIMHEEENL-------------DRL 5523
             +  + V +++    L Q +    + +S    L G +   EE L              + 
Sbjct: 3586 AD--ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 3643

Query: 5524 HQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKL------PLSDVAVKTLQNMNRQWIR 5577
             Q++KE     + H L L       + +NEVS  L         +   K + + N Q+  
Sbjct: 3644 QQRQKELKKEVMEHRLVL-------DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKL 3696

Query: 5578 ATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKML 5637
             + T  +R  E+                IQ  ++ E+A   ++A        ++K   + 
Sbjct: 3697 VSDTIGQRVDEIDAA-------------IQRSQQYEQAADAELAWVAE---TKRKLMALG 3740

Query: 5638 EAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDG 5697
               +  +QT A   V ++  +      ++  E  +  S++        + V Q K   + 
Sbjct: 3741 PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK--TES 3798

Query: 5698 LVRQWQDFTTSVENLFRFLTDTSHLLSAV-KGQERFS--LYQTRSLIHELKNKEIHFQRR 5754
            L++Q++  +      +  L     L++   +  E  S  + +TR+LI +L +  I  ++ 
Sbjct: 3799 LIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQL 3858

Query: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQ-FQSTVETWD 5813
            R       +  E   L   +   +    ++ ++    K++ P+  EM+++ +Q     + 
Sbjct: 3859 RQ------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYA 3912

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q ++++++    L    +QS   + E H+ +    E ++ L   L      +  L   + 
Sbjct: 3913 QIKEEVRQRALALDEAVSQSTQ-ITEFHDKIEPMLETLENLSSRL-----RMPPLIPAEV 3966

Query: 5874 DLTRHVLVE------DVMVLKEQIEHLHRQWEDLCLRVA-----IRKQEIEDRLNTWVVF 5922
            D  R  + +      ++  L+   E L R+ E+L  R       +  +EI+D+L+  V F
Sbjct: 3967 DKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFF 4026

Query: 5923 NEKNK--------------ELCA--W--LVQMENKVLQTADI-------SIEEMIEKLQK 5957
             E  K              EL    W  +  +   +  T DI        I+  I K Q 
Sbjct: 4027 WEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQV 4086

Query: 5958 DC----MEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR 6013
            +      EE +   E    ++ +G  LI A  ++   E+   ++++N+ W++L      R
Sbjct: 4087 EAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4146

Query: 6014 VKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCDDQEIQKRLAEQQDLQR 6071
            ++KL++      Q    +  +  WL     +L    PV  D+     ++ +L E ++ + 
Sbjct: 4147 LEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL---NTVKDQLNEMKEFKV 4203

Query: 6072 DIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKI 6131
            ++ Q    +E + +  +++L  +    +ET+ D I++    L   W N+      R+ K+
Sbjct: 4204 EVYQQQIEMEKLNHQGELMLKKA---TDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4260

Query: 6132 EETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLT 6191
            E       +F         WL   E                + EL +    +  +     
Sbjct: 4261 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQA 4320

Query: 6192 QLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFE 6251
             +E +NK    L   +  D AS L+  +   NQ W+++ ++     ++L+    Q + F 
Sbjct: 4321 TVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH 4380

Query: 6252 GTRESILVWLTEMDLQLT 6269
               E  L+ LT M+ QL+
Sbjct: 4381 SEIEDFLLELTRMESQLS 4398



 Score =  155 bits (392), Expect = 1e-36
 Identities = 648/3474 (18%), Positives = 1317/3474 (37%), Gaps = 477/3474 (13%)

Query: 3115 FKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETS-----LHVLNQIK 3169
            FKE EIL  +      ++LYK+L+ + +E    +L +    + +E       + +L + K
Sbjct: 359  FKETEILAKEREKGRIEELYKLLE-VWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREK 417

Query: 3170 SQLQQPLLINLEI-----KHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEAS 3224
            S   +P +  LE+       IQN   NCE   E++     +++A  A  +  +    E S
Sbjct: 418  S--LRPAVERLELLLQIANKIQNGALNCE---EKLTLAKNTLQADAAHLESGQPVQCE-S 471

Query: 3225 DVETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRV 3284
            DV   ++E E L  QL   +DL+  +L D  EN  + +E   R    +  L+  ++  R+
Sbjct: 472  DVIMYIQECEGLIRQL--QVDLQ--ILRD--ENYYQLEELAFR----VMRLQDELVTLRL 521

Query: 3285 DVGNPEE-----SLEM--------------PLRKQEELESTVAHIQDLTE-KLGMISSPE 3324
            +  N        SLE+              PL K     ST    + +T  +L  ISS E
Sbjct: 522  ECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSE 581

Query: 3325 AKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQ 3384
             +  L++ + EL+S    M+   K +  E    L + +   + ++ I+T++ +    LG 
Sbjct: 582  DEGNLRF-VYELLSWVEEMQ--MKLERAEWGNDLPSVELQLETQQHIHTSVEE----LGS 634

Query: 3385 SMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVS 3444
            S+    L   +  +    S A     + T+   +K     R+  L+        L K VS
Sbjct: 635  SVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQ-------SLHKFVS 687

Query: 3445 ALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATT 3504
                + + L E  +      EEL  +W   +  I  +      L  EL E  K     + 
Sbjct: 688  RATAELIWLNEKEE------EELAYDWSDNNSNISAKRNYFSELTMELEE--KQDVFRSL 739

Query: 3505 EELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERC 3564
            ++ +ELL                    L+   + Q V   S AV++     ++  MK+ C
Sbjct: 740  QDTAELLS-------------------LENHPAKQTVEAYSAAVQS-----QLQWMKQLC 775

Query: 3565 NKLLQKVQKNKELVQ--TEIQERHSFTKEI-IALKNFF---QQTTTSFQNMAFQDHPEKS 3618
              + Q V++N    Q  ++ +E  SF + +  ++K  +     T+ S      QD  ++ 
Sbjct: 776  LCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEK 835

Query: 3619 EQFEELQS------------ILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRK 3666
            EQ  + +S            +  K +     +   + +K    Y  +   I  + +EC  
Sbjct: 836  EQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITI-CKNDEC-- 892

Query: 3667 ALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDE 3726
             LED  ++   +V+  + + AM   +  +   +    K   + +  +E++ +    +W +
Sbjct: 893  VLEDNSQRTKWKVISPTGNEAM---VPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQ 949

Query: 3727 LDL-------WHSKLNELDS----EVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAEC 3775
            L +       W+    +LD      ++ +    PG+  + M NL   ++ + Q     + 
Sbjct: 950  LHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQ-----DS 1004

Query: 3776 RTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLS----HHASTVQMAL 3831
            R S L     ++     L +  EA      HL+ +  + D   T++         +++ L
Sbjct: 1005 RDSVLFSVADRLR----LEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRL 1060

Query: 3832 EDSEQK-HNLLHSIFMDLEDLSI-------IFETDELTQSIQELSNQVTALQQKIMESLP 3883
            E+ EQ+    + S+     D          I E +   + +Q+L + + A+  K    L 
Sbjct: 1061 EEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLH 1120

Query: 3884 QIQRMADDVVAIESEVKSMEKR-----------VSKIKTI------LLSKEIFDFSPEEH 3926
            Q    +  V  + SE+  + ++           ++K+KT+      +   E+     E  
Sbjct: 1121 Q-SPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIK 1179

Query: 3927 LKHGEVILENIRPMKKTIAEIVSYQVELR--------LPQTGMKPLPVFQRTNQLLQDIK 3978
            L   EV+L ++  ++   + +  +  +++        L +   K   V ++ ++L  +  
Sbjct: 1180 LSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERN 1239

Query: 3979 L-LENVTQEQNELLK---VVIKQTNEWDEEIENLKQILNNYSA------------QFSLE 4022
            L LE   ++ ++L +    VI Q      E+E+++++L +Y A                E
Sbjct: 1240 LDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQE 1299

Query: 4023 HMSPDQA-------DKLPQ---LQGEIERME---KQILSLNQRKEDLLVDLKATVLNLHQ 4069
             M P QA       ++L Q   L  EIER +    Q    +Q+   ++ D +  ++    
Sbjct: 1300 MMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKA 1359

Query: 4070 HLKQEQEGVERDR-----LPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSV 4124
             ++ +Q+   + R       A+T E   +  R  +   L  +       A+    EE  V
Sbjct: 1360 FVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKV 1419

Query: 4125 KSDNGDEKAEPSPQ--SWSSLWKHDKDMEEDRASSSSGTIVQEAY-------GKISTSDN 4175
              +   E  E   +   W S    +   +   + +   T +++A         +++T   
Sbjct: 1420 VEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKE 1479

Query: 4176 SMAQ-ILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
             +++ I T      + G + S +  +        +     D  D       +++      
Sbjct: 1480 QVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQ 1539

Query: 4235 TE------VLHACKTQVAELELWLQQANVAV---EPETLNADMQQVLEQQLVGCQAMLTE 4285
            TE        + C  Q+ +L  W+ QA  A+   +  T   D+   L++     + +  +
Sbjct: 1540 TEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL-SALQKNQSDLKDLQDD 1598

Query: 4286 IEHKVAFLLETCKD-QGLGDNGATQ---HEAEALSLKLKTVKCNLEKVQ--MMLQEKHSE 4339
            I+++        KD +G  +   T+    E  AL  KL   K   E +Q    + +K  E
Sbjct: 1599 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 1658

Query: 4340 DQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFI 4399
            +   + L++ +E          N  ++++++              Q +  L  MEQ    
Sbjct: 1659 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGG---QLLTNLPGMEQLSGA 1715

Query: 4400 KFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHEL 4459
              +E  A            DTT      NQA       P+ +     +  +  +  H EL
Sbjct: 1716 S-LEKGAL-----------DTTDGYMGVNQA-------PEKL----DKQCEMMKARHQEL 1752

Query: 4460 SSKIK--LPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQT 4517
             S+ +  +   Q  +  +  +   L        +    E  + Y+T L     E   +QT
Sbjct: 1753 LSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQT 1812

Query: 4518 QENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLE-------MPRLYREDGSGQQVHYET 4570
             ++  ++     D K FE +L  S+    +E M +       +P L +  GS  +   + 
Sbjct: 1813 LQDELQK--FLQDHKEFESWLERSE--KELENMHKGGSSPETLPSLLKRQGSFSE---DV 1865

Query: 4571 LALELKKLYLALSDKK----GDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSK 4626
            ++ +    ++ +S +K     +  K    P E  NL+    D L+   + T+      SK
Sbjct: 1866 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVK---DKLK---DATERYTALHSK 1919

Query: 4627 SLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQ-------QSLNEISGQSVA-------EQL 4672
              + G     S+ N +   YHQ   S  SLQ        ++ ++   +VA       EQL
Sbjct: 1920 CTRLG-----SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 1974

Query: 4673 QKADAYTVELENAESRVAKL----RDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYT 4728
                    EL   +  V KL    RD  E    P    + V +  D + S +  L     
Sbjct: 1975 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2034

Query: 4729 ELSS---PFVTESQQ-----DALLQ--GMVELVKIGKE--KLAHGHLKQ----------- 4765
            E SS     + +SQ      ++LLQ  G VE    GK+   L+ G +++           
Sbjct: 2035 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2094

Query: 4766 -TKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEE 4824
              + K +L+A  E    F +   AD         K L  + Q  E    +Q  +   L++
Sbjct: 2095 IARQKSSLEATREMVTRFME--TADSTTAAVLQGK-LAEVSQRFEQLCLQQQEKESSLKK 2151

Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASL-------EKDLEILISTLPSVSLVEE-------T 4870
               Q  M  + L  K ++F EN + +       ++D+      +  ++L  E       T
Sbjct: 2152 LLPQAEM-FEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2210

Query: 4871 EERLVERISF---------YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKL 4921
             E LV  +S          +Q   +N+      L +T+ E ++   + SC E   +  KL
Sbjct: 2211 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK--DASSCQEQLDEFRKL 2268

Query: 4922 EEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDL 4981
               +    K+ +  +   +         +  + +L K +E  +  L+ W  +   V +++
Sbjct: 2269 VRTFQKWLKETEGSIPPTET--------SMSAKELEKQIEHLKSLLDDWASKGTLV-EEI 2319

Query: 4982 DTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE----TDTATLRASLAQFEQKW 5037
            +   +++ N        D +    + + S+G+ +  +       D   ++  ++    K+
Sbjct: 2320 NCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKY 2379

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHL 5097
              L   L + QE L  +        K    ++ W+ + E      D++ SP+    VK  
Sbjct: 2380 EKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQ 2439

Query: 5098 LQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGM 5157
             + +K F  E++     +  V ++L  L      S+  E  +  +   E+N +W R   +
Sbjct: 2440 AESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQE--ELNSRWERATEV 2497

Query: 5158 LNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIEN 5217
               + + LE+    +   +     L  WL  +E  +  L      +S+   +L+ Q  + 
Sbjct: 2498 TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL----GPLSIDPNMLNAQKQQV 2553

Query: 5218 QLAIKS--------KALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLK 5269
            Q  +K         + L+E  Q  LT               +  + QK   +  ++N   
Sbjct: 2554 QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS 2613

Query: 5270 TSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES 5329
            + +   + +   Y +L  +++         +     +    E ++ Q+E    ++ + E 
Sbjct: 2614 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQ 2673

Query: 5330 SEGSWEKLQEVIGKLKGLCPS--VAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLW 5387
             +   ++ Q +  +L  L     + + ++++ +        +    AD++ + Q+ L   
Sbjct: 2674 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 2733

Query: 5388 KAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAF- 5446
            + +     E    L  +++  QQ  N  +S     E L   LQ+ +E Q  + +   ++ 
Sbjct: 2734 QQFQQMFDELRTWLDDKQS--QQAKNCPISAK--LERLQSQLQENEEFQKSLNQHSGSYE 2789

Query: 5447 ---LQNSSVLDRLPQPAESST--HMLLPGPLH-------SLQRAAYLEKMLLVKANEFEF 5494
                +  S+L  +P   E  T  + L+    H       +  R + L K  + KA ++++
Sbjct: 2790 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRL-KDCMQKAQKYQW 2848

Query: 5495 ----VLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEH 5550
                ++   +D   ++  L+  +   +     L  +   N       +L +   + DI  
Sbjct: 2849 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 2908

Query: 5551 LNEVSLKLPLSDVAVKTLQNMN--RQWIRATATALE----RCSELQGIGLN-EKFLYCCE 5603
             +  + +  + D      QNM+   + ++A   +LE    R  E Q    N EK +   +
Sbjct: 2909 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 2968

Query: 5604 KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE 5663
              +++ + +    +     +L +L  QQ+  + LE +V   +      V  +    D ++
Sbjct: 2969 HQLEIFDAL--GSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ 3026

Query: 5664 IENRPEFI-TEFSKLTDR-------WQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRF 5715
            + ++ E    EF ++  R        +N ++G+ Q    V  +  Q  D    ++ +   
Sbjct: 3027 LLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAI 3086

Query: 5716 LTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLK 5775
              DT  L S ++    F      + IH LK   +  +     C   LE    L L    +
Sbjct: 3087 GRDTDSLQSQIEDVRLF-----LNKIHVLK---LDIEASEAECRHMLEEEGTLDLLGLKR 3138

Query: 5776 TKESVGRRISQLQDSWKDMEPQL---AEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ 5832
              E++ ++  +L +  K  + QL      ++ F   ++  +      +E ++   V+  +
Sbjct: 3139 ELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTE 3198

Query: 5833 SEDPLPELHEDLHNEKELIKELE---QSLASWTQNLKELQTMKADLTRHVLVEDVMVLKE 5889
             E    +L +    +KE +  L+   Q +    Q L  +Q+   D        DV  L+ 
Sbjct: 3199 VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDC-------DVQGLEH 3249

Query: 5890 QIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIE 5949
             +E ++ +W  L  +VA R  ++++ L     F +  + L +WL   E  +      S E
Sbjct: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAE 3309

Query: 5950 EMIEKLQKDCMEEINLFSENKL----QLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
              + K Q    + +    +++      L+  G ++ +++  +   +I  +L  +  RW  
Sbjct: 3310 YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTE 3369

Query: 6006 LFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCDDQEIQKRL 6063
            L     +R K+L++     +Q  +    +  +L+  E +L  S+PV        +IQ+++
Sbjct: 3370 LLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA---KIQQQI 3426

Query: 6064 AEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAM 6123
               + L+ DIE H+  V     I   L     +  +  E   + +   SL  R+  I   
Sbjct: 3427 IRHKALEEDIENHATDVHQAVKIGQSL----SSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482

Query: 6124 SMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAAC----PNSSEVLYTSAKEELKRF 6179
               +   +++     + F +D     +WL   E   +         +VL+    + L   
Sbjct: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHL--- 3539

Query: 6180 EAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRR 6239
             A   +I  R   ++   K  + L ++   +    +++ +     R+ ++    +  LR 
Sbjct: 3540 -ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 3598

Query: 6240 LRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            L        +F+ T E +  WL E++ +L       +S   +++ Q    Q+E+
Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELAT--SGGQSPTGEQIPQFQQRQKEL 3650



 Score =  123 bits (309), Expect = 6e-27
 Identities = 598/3292 (18%), Positives = 1233/3292 (37%), Gaps = 542/3292 (16%)

Query: 1125 ILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHV 1184
            +LE + Q  K+++ S   +E    S C      +   I+  +       ++++L  + HV
Sbjct: 893  VLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHV 952

Query: 1185 ND--------IKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCG 1236
            N         ++K   + +   L++         +  M++L+      L   + S+L   
Sbjct: 953  NTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSV 1012

Query: 1237 SDLPLHKMAIQGFHLIDADRIYQHL------RNIQDSIAKQI--EICN---RLEEPGNFV 1285
            +D    +  ++          +QHL       + ++++AK    E+ N   RLEE    V
Sbjct: 1013 ADRLRLEEEVEA-----CKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRV 1067

Query: 1286 LKELHPF-----DLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAE 1340
            +K +        D  A Q+  L           R+   E T + L+   + L    +  +
Sbjct: 1068 VKRIQSLASSRTDRDAWQDNAL-----------RIAEQEHTQEDLQQLRSDLDAVSMKCD 1116

Query: 1341 PVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKH--------LDKCLKMLDMSFKDAE 1392
                 S S +        +V     E++L+ +K  H        L+K LK +D+  +  +
Sbjct: 1117 SFLHQSPSSS--------SVPTLRSELNLLVEKMDHVYGLSTVYLNK-LKTVDVIVRSIQ 1167

Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
                   E L+  + IKLS+      +E    +   LEA        L +++D  S  S 
Sbjct: 1168 -----DAELLVKGYEIKLSQ------EEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSV 1216

Query: 1453 IGLKDPTVPAVKHRKKSLIRLDKV----LDEYEEEKRHLQEMANSLPHFKDGREKTVN-- 1506
            +   D  +   K   + + RL       L+ Y+E+   LQE  + +    + R+  +   
Sbjct: 1217 L---DEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESI 1273

Query: 1507 -------QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVIS 1559
                   + C  T++ W          +E+     E++K  Q           ++  V+S
Sbjct: 1274 QEVLGDYRACHGTLIKW----------IEETTAQQEMMKPGQ----------AEDSRVLS 1313

Query: 1560 LQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKE 1619
             Q S           AEIE  + + ++  +   + + + K+ +  L   K F E   +  
Sbjct: 1314 EQLSQQ-----TALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSP 1368

Query: 1620 ANIIVDRWLDINEK-TEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEED 1678
                  R L  ++  T+++ +   R  AL      L     ++   AL+++E      E+
Sbjct: 1369 GKR--RRMLSSSDAITQEFMDLRTRYTAL----VTLTTQHVKYISDALRRLE------EE 1416

Query: 1679 RERLKEELQVHEQKTSEFSRRVAEI----QFLLQSSEIP---------LELQVMESSILN 1725
             + ++EE Q H +K  E    V+ +    Q    SSE           LE QV+   +  
Sbjct: 1417 EKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTT 1476

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K E V + +       A  G     +E   Q   Q+         L    +     +L++
Sbjct: 1477 KKEQVSEAIKTSQIFLAKHGHKLSEKEK-KQISEQLNALNKAYHDLCDGSA----NQLQQ 1531

Query: 1786 IQQQILQQKHSMILLENQIGC--LTPELSELKKQYESV-----SDLFNTKKSVLQDHFSK 1838
            +Q Q+  Q     L + Q  C     +L     Q E               S LQ + S 
Sbjct: 1532 LQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 1591

Query: 1839 L--LNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDS 1896
            L  L D  +N    F+ +  +++   E ++TK S  +          L     K+ Q   
Sbjct: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE----------LTALREKLHQAKE 1641

Query: 1897 VLKHVKKH--LPKAHVKELISWLVGQEFELEKMESICQARAKELEDSL-----------Q 1943
              + +++   + +  ++E ++  + QE E  K         K+++  L           Q
Sbjct: 1642 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 1701

Query: 1944 QLLRL----QDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQ---- 1995
             L  L    Q    +L K   +  + + G+ +  EK +  C+ +  + ++  S  Q    
Sbjct: 1702 LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFIL 1761

Query: 1996 ----LNNSLKEYG--FTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFN 2047
                    L ++G   T EE+ +++     L ++Y T L Q     ++ + L  E Q F 
Sbjct: 1762 ATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFL 1821

Query: 2048 DLAHDVIHWIKEIKESLMVLN---SSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQA 2104
                +   W++  ++ L  ++   SS   +P   + Q      ++  +GD R  TI  Q 
Sbjct: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881

Query: 2105 ------------ESSE-APLVQKTLTDISNQWDNTLHLASTYL-SHQEKLLLEGEKYLQS 2150
                        E SE   LV+  L D + ++   LH   T L SH   LL +  ++  S
Sbjct: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERY-TALHSKCTRLGSHLNMLLGQYHQFQNS 1940

Query: 2151 KEDLRLMLIELKKKQEA---------------GFALQHGLQEKKAQLKI-YKKFLKKAQD 2194
             + L+  +   +   E                  A    LQE+ A+ ++  +K  K A+D
Sbjct: 1941 ADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD 2000

Query: 2195 LTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSY 2254
            +  +  E      ++ E T +          I    +SL   L +    L   + +  S 
Sbjct: 2001 IMEIEGEPAPDHRHVQETTDS----------ILSHFQSLSYSLAERSSLLQKAIAQSQSV 2050

Query: 2255 QVCVTDLNTTL----DNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKIL 2310
            Q  +  L  ++     N   + VS     V Q A+   ++  Q++  + S  + T + + 
Sbjct: 2051 QESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT 2110

Query: 2311 ALAKSVKQNTSSVGQ---KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
               ++    T++V Q     +    + L  +Q++ E+ L     + E   +   K ++  
Sbjct: 2111 RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2170

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAM---SKQLSLNAQ 2424
            E K +    G   Q   D+    Q+   +    ED + N D+   +     S   +L+  
Sbjct: 2171 ENKSRMLASGN--QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC 2228

Query: 2425 ESMKNTEDERK-VNELQN--QPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECL 2481
            +     ++ RK   ELQ   +  E D     EQL+E  KL    +      K L++TE  
Sbjct: 2229 QHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQ------KWLKETE-- 2280

Query: 2482 NKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLT 2541
                 G++       SA+ L+  ++ L +L  +  S+  ++ +      ++E+ +  +  
Sbjct: 2281 -----GSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITA 2335

Query: 2542 DKESLKVGPLDSVTYLDKIKKFIASIEKE---KD------SLGNLKIKWENLSNHVTDMD 2592
                 K G +     L  +   + S+      KD       + ++ +K+E L   + +  
Sbjct: 2336 PDSQGKTGSI-----LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390

Query: 2593 KKL--LESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHL- 2649
            + L  + ++++++      V Q ++ K  ++V++  +  +   K +  +   +  +  L 
Sbjct: 2391 ESLQAILNRMEEVHKEANSVLQWLESK--EEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448

Query: 2650 QLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEK------EKKNLE 2703
            +L   SP+ +   +++  L      ++   +  K Q EL  +  W          ++ LE
Sbjct: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR--WERATEVTVARQRQLE 2506

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILS 2763
            +  ++L             AE+Q++   +  ++         ++G L P + + P+ + +
Sbjct: 2507 ESASHLA--------CFQAAESQLRPWLMEKEL---------MMGVLGP-LSIDPNMLNA 2548

Query: 2764 QIRKCKVTHDGILARQQSVESLAEEVKDKV--PSLTTYEGSDLNNTLEDLRNQYQMLVLK 2821
            Q ++ +       AR+Q  E L E  +  +  P   +   S +   L+ +  ++  L  K
Sbjct: 2549 QKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDK 2608

Query: 2822 STQRSQQLEFKLEERSNFFAIIRKFQLMVQE-SETLIIPRVETAATEAELKHHHVTLEAS 2880
               RS Q++  + + + +  +++     V+   + L +    +   EA  +    T E  
Sbjct: 2609 LNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEI- 2667

Query: 2881 QKELQEIDSGISTHLQELTNIYEELNVF-ERLFLEDQLKN----LKIRTNRIQRFIQNTC 2935
            + +L+++D  +    +E   + +EL+V     +L+D+LK     + +    ++    +  
Sbjct: 2668 RSDLEQLDHEV----KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRI 2723

Query: 2936 NEVEHKIKFCRQFHEKTSALQEEADSIQ----------------RNELLLNQEVNKGVKE 2979
            N ++  +   +QF +    L+   D  Q                +++L  N+E  K + +
Sbjct: 2724 NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ 2783

Query: 2980 EIYNLKDRLTAIKCCILQVL--KLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQ 3037
               + +  +   +  +L V   + K+           +QL +L+    E  K+  ++  +
Sbjct: 2784 HSGSYEVIVAEGESLLLSVPPGEEKRTLQ--------NQLVELKNHWEELSKKTADRQSR 2835

Query: 3038 LDTFEEEHGKYQALLSKMRAIDLQIK-KMTEVVLKAPDSSPESRRLNAQILSQRIEKAKC 3096
            L    ++  KYQ  +  +       K KM+E+ +       ES  L ++ +   +EK + 
Sbjct: 2836 LKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRS 2895

Query: 3097 LCDEIIKK-----LNENKTFDDSFK-EKEILQIKLNAEENDKLYKV--LQNMVLELSPKE 3148
            L  EI+       +N ++  +D  + EK  +   ++A   +   K   L+ M   L   +
Sbjct: 2896 LL-EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ 2954

Query: 3149 LDEKNCQDKLETSLHVL--------------NQIKSQLQQPLLINLE--IKHIQN----- 3187
               KN + K+E + H L              N  K + QQ +L  LE  + +++N     
Sbjct: 2955 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3014

Query: 3188 ---EKDNCEAFQEQVWAEMCS--------------------IKAVTAIEKQREENSSEAS 3224
                 D  +A Q    AE+                      ++ +     +  E  S+ +
Sbjct: 3015 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA 3074

Query: 3225 DVETKL-------REFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEA 3277
            D++ +L       R+ + LQ Q+   + L  N ++    ++   +      +E   +L+ 
Sbjct: 3075 DLDDELDGMGAIGRDTDSLQSQIE-DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133

Query: 3278 IIIPYRVDVGNPE--ESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            + +   ++  N +  +  E    +QE+LE T+  ++D   KL  ++      +    LQ 
Sbjct: 3134 LGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW 3193

Query: 3336 LVSKNSAMKEAFKAQETEAE---RYLENYKCYRKMEEDIYTNLSKMETVLGQSM------ 3386
            +V              TE E   + L ++K ++K + D      +    LGQ +      
Sbjct: 3194 VVG-------------TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3240

Query: 3387 ----SSLPLSYREALERLEQSKALVSNLISTKEELM----KLRQILRLL--------RLR 3430
                  L     E   R       V+  I+  +E +    K +  L  L         L 
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300

Query: 3431 CTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIE---REAII--L 3485
              +       K+V A  ++   L     + +   + L+ E   +++  E   RE I   L
Sbjct: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3360

Query: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
            ++L+    E+  +K AA  ++L ++L    Q+ E  E     L++  +++ + + V   +
Sbjct: 3361 ESLESRWTEL-LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3419

Query: 3546 GAVE---------------------------------TVPAFQ-----EITSMKERCNKL 3567
              ++                                 T PA Q     +I S++ R +++
Sbjct: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3479

Query: 3568 LQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSF---------QNMAFQDHPEKS 3618
              +  +   L+   +     F ++ + + N+  +              Q++  + H +  
Sbjct: 3480 QDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHL 3539

Query: 3619 EQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNE 3678
               EE+ +  K      +N    L+    E   +    I+ +++  +    DI    S  
Sbjct: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLL----IQEKLDGIKTRYADITVTSSKA 3595

Query: 3679 VLKSSPSYAMRRKI----EEINNGLHNVEKML------QQKSKNIEKAQEIQKKMWDELD 3728
            +     +  +  K     EE+   L  VE+ L          + I + Q+ QK++  E+ 
Sbjct: 3596 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655

Query: 3729 LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF-QQYQQVSQRAECRTSQLNKATVKM 3787
                 L+ ++   + ++E  P +A+E +D L+    +QY+ VS     R  +++ A  + 
Sbjct: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715

Query: 3788 EEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNLLHSIFMD 3847
            ++Y     +  AW+  T   L           L    +T Q+ ++ +     + H   MD
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPI----RLEQDQTTAQLQVQKAFSIDIIRHKDSMD 3771

Query: 3848 --LEDLSIIFET---------DELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIE 3896
                  S IF T          E T+S+ +    ++ L  +    L + Q + +      
Sbjct: 3772 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 3831

Query: 3897 SEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELR- 3955
             E+    +    +   L S  I      +  +    + E+I   K  I +++    +L+ 
Sbjct: 3832 EELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE 3891

Query: 3956 -LPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQT--NEWDEEIENLKQIL 4012
              P+ G      +Q+   +   IK  E V Q    L + V + T   E+ ++IE + + L
Sbjct: 3892 LNPEEGEMVEEKYQKAENMYAQIK--EEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949

Query: 4013 NNYSAQFSLEHMSPDQADKLPQLQG-------EIERMEKQILSLNQRKEDLL 4057
             N S++  +  + P + DK+ +          E+E+++    +L +R E+L+
Sbjct: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001



 Score =  122 bits (307), Expect = 9e-27
 Identities = 749/4037 (18%), Positives = 1513/4037 (37%), Gaps = 677/4037 (16%)

Query: 167  PPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPD 226
            PP K   ++ +R + S +K + LW Q    T   +       SW          + LR D
Sbjct: 924  PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLI-------SW----------NYLRKD 966

Query: 227  LIDMKSVKHRSNKDNLREAFRIAEQEL-KIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYS 285
            L     +    N + LR +   A  E  +I + L+    D +     S++  VA  L+  
Sbjct: 967  L----DLVQTWNLEKLRSS---APGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLE 1019

Query: 286  KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEND----TYFKKYNSLLSFMESFNE 341
            ++                      K + Q L+K  EN+    T  K Y S L  +    E
Sbjct: 1020 EEVEAC------------------KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLE 1061

Query: 342  EKKSFLDVLSIKRDLDELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQE 401
            E +  +    +KR +  L       R+AW     Q NA +I         L Q  + L  
Sbjct: 1062 EYEQRV----VKR-IQSLASSRTD-RDAW-----QDNALRIAEQEHTQEDLQQLRSDLDA 1110

Query: 402  VEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPN 461
            V    D  L  S   S   TL  E       L+++ +H   +   + NK +         
Sbjct: 1111 VSMKCDSFLHQSPSSSSVPTLRSE----LNLLVEKMDHVYGLSTVYLNKLKT-------- 1158

Query: 462  KLEEMKRRINN--ILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV-ELL 518
             ++ + R I +  +L K + + L         L  ++   S L  W      + SV  +L
Sbjct: 1159 -VDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVL 1217

Query: 519  LEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVK 578
             E+  K     E ++RL        E Y+    + Q   +++  V + + + +  + +++
Sbjct: 1218 DEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ---ERWHRVIAQLEIRQSELESIQ 1274

Query: 579  STLQKVLACWATYVENLRLLRACFEETK--KEEIKEVPFETLAQWNLEHATLNEAGNFLV 636
              L    AC  T ++ +    A  E  K  + E   V  E L+Q     A +      L 
Sbjct: 1275 EVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKL- 1333

Query: 637  EVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKA 696
                         + ++ ++++  +V   +L++       +  Q +      +LS  +  
Sbjct: 1334 ------------DQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAI 1381

Query: 697  TVEFSTDMSVELPENYNQNIKAGEKHEK---------ENEEFTGQLKVAKDVEK---LIG 744
            T EF     ++L   Y   +    +H K         E EE   + +  + VEK   L+G
Sbjct: 1382 TQEF-----MDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLG 1436

Query: 745  QVEIW--EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQE 802
             V       + K+   +    T +E   K ++ +  + +EL  + E         +S   
Sbjct: 1437 WVSTLARNTQGKATSSETKESTDIE---KAILEQQVLSEELTTKKEQ--------VSEAI 1485

Query: 803  SFQHVLTTGLQAKIQEAKEKVQIN--VVKLIAALKNLTDVSPD----LDIRLKMEESQKE 856
                +       K+ E KEK QI+  +  L  A  +L D S +    L  +L  +  QK 
Sbjct: 1486 KTSQIFLAKHGHKLSE-KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKT 1544

Query: 857  LESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLE 916
            L+       Q   Q E     + + + AL     ++  + L A+++ ++++ +D++  ++
Sbjct: 1545 LQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL-KDLQDDIQ 1600

Query: 917  EKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLI 976
             ++       +               DIE G + +N  KL     +E   +R    +   
Sbjct: 1601 NRATSFATVVK---------------DIE-GFMEENQTKLSP---RELTALREKLHQA-- 1639

Query: 977  KEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEI 1036
            KE      EE  + Q      V   L +E    K+ +E    L + ++KI+ LL   + +
Sbjct: 1640 KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKE----LAENKKKIDALLDWVTSV 1695

Query: 1037 ---------HMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTM 1087
                     ++       G S  +G + T++   G   ++AP  K D Q    KA     
Sbjct: 1696 GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGV--NQAP-EKLDKQCEMMKARH--- 1749

Query: 1088 KFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDR 1147
                       QE    ++++  +  S        +  L+ H  N         + EE +
Sbjct: 1750 -----------QELLSQQQNFILATQSA-------QAFLDQHGHN--------LTPEEQQ 1783

Query: 1148 SSSCLQAKLTDLQVIKN----ETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERE 1203
                LQ KL +L+   +    +++A  K+ + +  +L+  + D K+         L+  E
Sbjct: 1784 M---LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE-----FESWLERSE 1835

Query: 1204 RELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRN 1263
            +EL+  ++    S ET   L+      S  +      L  + I G  ++D +  ++  + 
Sbjct: 1836 KELE-NMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 1894

Query: 1264 IQDSIAKQIEICNRLEEPGNFVLKELHPFD-----LHAMQNIILKYKTQFEGMNHRVQRS 1318
                            E GN V  +L         LH+    +  +     G  H+ Q S
Sbjct: 1895 PS--------------EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 1940

Query: 1319 EDTLKALEDFLASLRTAKLSAEPV-TDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHL 1377
             D+L+A       ++  + + E + +D  ASD  V QE   T K  + E+   +   + L
Sbjct: 1941 ADSLQAW------MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 1994

Query: 1378 DKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNN 1437
             K  + + M  +     D    +   D+       +H   +     E + LL+  I ++ 
Sbjct: 1995 QKVARDI-MEIEGEPAPDHRHVQETTDSIL-----SHFQSLSYSLAERSSLLQKAIAQSQ 2048

Query: 1438 ELLKNIQDVQSQISKI--GLKDPTVPAVKHR--KKSLIRLDKVLDEYEEEKRHLQEMANS 1493
             + ++++ +   I ++   L+   V ++     +++L    K+  +   +K  L+     
Sbjct: 2049 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2108

Query: 1494 LPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQK 1553
            +  F +  + T       T  + +   A V++  EQ      L  Q Q  +S L  L+ +
Sbjct: 2109 VTRFMETADST-------TAAVLQGKLAEVSQRFEQ------LCLQQQEKESSLKKLLPQ 2155

Query: 1554 EESVISLQASYMG-KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
             E    L        EN  + +A      ++     + + ++N   ++ Q          
Sbjct: 2156 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ---------- 2205

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                           LD  E       + G AL L      ++N+  ++TE  LQK    
Sbjct: 2206 -------------ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTE--LQKTVKE 2250

Query: 1673 QLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQK 1732
            +  E+D    +E+L    +    F + + E +  +  +E  +  + +E  I    EH++ 
Sbjct: 2251 R--EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQI----EHLKS 2304

Query: 1733 CLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSL-EIFTKLEEIQQQI- 1790
             L   +       S   L E+++   T +   E+L+  ++  DS  +  + L  +   + 
Sbjct: 2305 LLDDWA-------SKGTLVEEINCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVG 2354

Query: 1791 -LQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL--LNDQCKNF 1847
             +   H+   L  +I C   ++S++  +YE +  + + ++  LQ   +++  ++ +  + 
Sbjct: 2355 SVNGYHTCKDL-TEIQC---DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2410

Query: 1848 NDWFSNIKVNLKECFESSETKKSVEQKLQKLSD--FLT-LEGRNSKIKQVDSVLKHVKKH 1904
              W  + +  LK     S   K+   K Q  S+  FL  LE  + KI++V   L  +   
Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2470

Query: 1905 LPKAHVKELISWLVGQEFEL----EKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLT 1960
             P +   E  +W   QE EL    E+   +  AR ++LE+S   L   Q     LR WL 
Sbjct: 2471 YPNSQEAE--NWKKIQE-ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527

Query: 1961 NQEEKWKGMEEP-----------GEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEE 2009
             ++E   G+  P            ++ +   +    +R+Q E   QLN + +    T   
Sbjct: 2528 -EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE---QLNEAAQGI-LTGPG 2582

Query: 2010 EIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQ---------SFNDLAHDVIHWIKEI 2060
            ++ +  + +    Q++ ++   +E  DKL     Q          + +L  D+   ++ +
Sbjct: 2583 DVSLSTSQVQKELQSINQKW--VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640

Query: 2061 KESLMVLN---------------SSEGKMPLEERIQKIKEIILLKPEGDARI-ETIMKQA 2104
             + L V +               +SE +  LE+   ++KE   L  E    I E  +K  
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 2700

Query: 2105 ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKK 2164
                   ++K L  ++        LA+  ++  +  L   +++ Q  ++LR  L + + +
Sbjct: 2701 -------LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 2753

Query: 2165 QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECT---KNPSFSEE 2221
            Q     +   L+  ++QL+  ++F K     +   + + ++G  LL      +     + 
Sbjct: 2754 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 2813

Query: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVD 2281
              +E+K+  E L ++  D    L   +++   YQ  V DL   +++  K  +S     +D
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED-CKAKMSELRVTLD 2872

Query: 2282 QIAVEEKLQK----LQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD------ 2331
             + +E  L +    L E+E R SL +     IL  A  +  N+S   +  I+D+      
Sbjct: 2873 PVQLESSLLRSKAMLNEVEKRRSLLE-----ILNSAADILINSSEADEDGIRDEKAGINQ 2927

Query: 2332 ----------------------IKSLQCKQKDLENRLASAKQEME--------CCLNSIL 2361
                                  ++  Q   K++E ++  AK ++E         C N  L
Sbjct: 2928 NMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL 2987

Query: 2362 KSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQL 2419
            +  R+ ++  +   P  +  +  T  + E   + +   +L    E+ +   +E+   KQ 
Sbjct: 2988 EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV---KQR 3044

Query: 2420 SLNAQESMKNT-----EDERKVNELQNQPLELDTML------------RNEQLEEIEKLY 2462
              +    M+N      +   +V E+ +Q  +LD  L               Q+E++    
Sbjct: 3045 VNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFL 3104

Query: 2463 TQLEAKKAAIKPLEQTECLNK-TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
             ++   K  I+  E  EC +   E G L L  +    + L+     L    K ++ Q  +
Sbjct: 3105 NKIHVLKLDIEASE-AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLEL 3163

Query: 2522 ----LRDFQEYLAAVESSMKALLTDKESLK--VGPLDSVTYLDKIKKFIASIEK-EKDSL 2574
                + DF   L  +  +  A   + E+L+  VG     T ++ I + +A  +  +K+ +
Sbjct: 3164 TLGRVEDFYRKLKGLNDATTA-AEEAEALQWVVG-----TEVEIINQQLADFKMFQKEQV 3217

Query: 2575 GNLKIKWENLSNHVTDMDKKLLES-----QIKQLEHGWEQVEQQ---IQKKYSQQVVEYD 2626
              L++K +     V  + + L++S      ++ LEH  E++  +   + KK +Q++ +  
Sbjct: 3218 DPLQMKLQ----QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3273

Query: 2627 EFTTLMNKVQDT---EISLQQQQQHLQLRLKSPEE-----RAGNQSMIALTTDLQATKHG 2678
            E      K QD     +S     + L    K P       +A  Q    L   L   K  
Sbjct: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333

Query: 2679 FSVLKGQ-AELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMK 2737
              +L+ +   +       ++EK  +   + +L+ +W  L          + K   R K  
Sbjct: 3334 VDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTEL----------LSKAAARQKQL 3381

Query: 2738 ETIL-WAKNLLGELNPSIPLL---------PDDILSQIRKCKVTHDGILARQQSVESLAE 2787
            E IL  AK       P    L          + + +Q  K +       A ++ +E+ A 
Sbjct: 3382 EDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHAT 3441

Query: 2788 EVKDKV------PSLTT-YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
            +V   V       SLT+  E   L+  ++ L+ +Y  +  +  +++  L+  L     F 
Sbjct: 3442 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 3501

Query: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
                +    + E E  +         +  L   H    A  +E+      +   ++    
Sbjct: 3502 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 3561

Query: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEAD 2960
            + ++    E L ++++L  +K R       I  T ++    ++  RQ   K  +  EE  
Sbjct: 3562 LLKQTTGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLATKFQSTYEELT 3617

Query: 2961 SIQR--NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIG--------- 3009
               R   E L          E+I   + R   +K    +V++ + V D +          
Sbjct: 3618 GWLREVEEELATSGGQSPTGEQIPQFQQRQKELK---KEVMEHRLVLDTVNEVSRALLEL 3674

Query: 3010 LNWDFSQ-LDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEV 3068
            + W   + LD+L +   E+ K + + I Q    +E     Q      +A D ++  + E 
Sbjct: 3675 VPWRAREGLDKLVSDANEQYKLVSDTIGQ--RVDEIDAAIQRSQQYEQAADAELAWVAET 3732

Query: 3069 VLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAE 3128
              K     P   RL     + +++  K    +II+      + D+ F  +  +      E
Sbjct: 3733 KRKLMALGP--IRLEQDQTTAQLQVQKAFSIDIIR---HKDSMDELFSHRSEIFGTCGEE 3787

Query: 3129 ENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQ-----------------IKSQ 3171
            +   L +  ++++ +     L       +LE +  ++NQ                 + +Q
Sbjct: 3788 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ 3847

Query: 3172 LQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQ-REENSSEASDVETKL 3230
            L  P    ++ + ++ +++     +E +      I  +  I  Q +E N  E   VE K 
Sbjct: 3848 LPSPA---IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY 3904

Query: 3231 REFEDLQMQLNTSIDLRTNVLNDAYE---NLTRYKEAVTRAVESITSLEA-----IIIPY 3282
            ++ E++  Q+   +  R   L++A      +T + + +   +E++ +L +      +IP 
Sbjct: 3905 QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA 3964

Query: 3283 RVD------VGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQEL 3336
             VD        N   ++E+     E+L+ +   ++   E+L   S    K      +Q+ 
Sbjct: 3965 EVDKIRECISDNKSATVEL-----EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019

Query: 3337 VSKNSAMKEAFKAQETEAE-RYLENYKCYRKMEEDIYTNLSKMETV--LGQSMSSLPLSY 3393
            + +     E  KA+  E E ++L+  +   K   D+   L+ ++    +   + S  +  
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079

Query: 3394 REALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSL 3453
                +++E ++ +        EEL  +R +   L   C E +   + K +  +   W +L
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4139

Query: 3454 LEAAKEWEMWCEELKQEWKFVSEEIEREAIILDN-----------------LQEELPEIS 3496
             +  KE     E+  Q      + ++     LDN                 ++++L E+ 
Sbjct: 4140 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMK 4199

Query: 3497 KTK-----EAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPES------- 3544
            + K     +    E+L+   + + +   +   + ++   L +     +N+ E        
Sbjct: 4200 EFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHK 4259

Query: 3545 -SGAVETVPAFQ----EITSMKERCNKLL---QKVQKNKELVQTEIQERHSFTKEIIALK 3596
              GA+  +  FQ    E+ S      +LL   + +  + ++++ E+ + H    +++A  
Sbjct: 4260 LEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA-- 4317

Query: 3597 NFFQQTTTSFQNMAFQDHPEKS--EQFEELQSILKKGKLTFENIMEKLRIKYSEMY-TIV 3653
                Q T    N A  +  E S  +    L+S L+     +E++++K   +  ++  T+ 
Sbjct: 4318 ---HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQ 4374

Query: 3654 PAE-IESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
             A+   S++E+    L  ++ ++S            R +++       ++E   Q K+K 
Sbjct: 4375 QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT------HMELYSQLKAK- 4427

Query: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
                +E   ++ D+              +  +   D G   +   ++ +  Q++  VS +
Sbjct: 4428 ----EETYNQLLDK------------GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4471

Query: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALE 3832
             E R S+L +A     E+ + L+    W+      L N A   SL       +TV   +E
Sbjct: 4472 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSL-----ILNTVLSQIE 4525

Query: 3833 DSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDV 3892
            +        H +F +     +    D++ + + +  NQ+  L QK             DV
Sbjct: 4526 E--------HKVFAN----EVNAHRDQIIE-LDQTGNQLKFLSQK------------QDV 4560

Query: 3893 VAIESEVKSMEKRVSKI 3909
            V I++ + S++ R  K+
Sbjct: 4561 VLIKNLLVSVQSRWEKV 4577



 Score =  122 bits (305), Expect = 2e-26
 Identities = 555/3237 (17%), Positives = 1235/3237 (38%), Gaps = 420/3237 (12%)

Query: 396  EAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHL 455
            +AW+Q  E  +++ LS +      V  +QE++   K L +    H               
Sbjct: 1945 QAWMQACEANVEKLLSDTVASDPGV--LQEQLATTKQLQEELAEHQ-------------- 1988

Query: 456  PLVPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV 515
              VP  KL+++ R I  I  +        H +   V    D + S     ++ Y   E  
Sbjct: 1989 --VPVEKLQKVARDIMEIEGEP----APDHRH---VQETTDSILSHFQ--SLSYSLAERS 2037

Query: 516  ELLLEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCM------ 569
             LL +      + +     L++  Q  GE+ +NL G      KQ   + S V        
Sbjct: 2038 SLLQK---AIAQSQSVQESLESLLQSIGEVEQNLEG------KQVSSLSSGVIQEALATN 2088

Query: 570  --YRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHAT 627
               +++I   KS+L+        ++E      A   + K  E+ +   +   Q   + ++
Sbjct: 2089 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2148

Query: 628  LNEAGNFLVEVSNDVVGSSISKELRR-LNKRWRKLVSKTQLEMNLP---LMIKKQDQPTF 683
            L +       +    +   +S +L++ +  + R L S  Q + ++      I++ +    
Sbjct: 2149 LKKL------LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEME 2202

Query: 684  DNSGNILSKEEKATVEFSTDMSVELPENYN--QNIKAG----EKHEKENEEFTGQLKVAK 737
            D   N+ + E   T   S   +++L ++ +  QN++      +K  KE E+     +   
Sbjct: 2203 DQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQL 2262

Query: 738  D-VEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQ 796
            D   KL+   + W  E +  +   +   S +E  K +    S+ D+  ++   + +++ +
Sbjct: 2263 DEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCK 2322

Query: 797  NISSQESFQHVLTTGLQAKIQEAKEKVQINV--VKLIAALKNLTDVSPDL-DIRLKMEES 853
              S +     +     Q K       V  +V  V      K+LT++  D+ D+ LK E+ 
Sbjct: 2323 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKL 2382

Query: 854  QKELESYMMRAQQLLGQRESPGELISKHKEA-LIISNTKSLAKYLKAVEELKNNVTEDIK 912
               L       Q +L + E        HKEA  ++   +S  + LK+++ + +    +  
Sbjct: 2383 GGVLHERQESLQAILNRMEEV------HKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2436

Query: 913  MSLEEKSRDVCAKWESLHHELSLYVQQLK---IDIEKGKLSDNILKLEKQINKE-----K 964
             +  E ++   A+ E    ++    + L    +     + ++N  K+++++N       +
Sbjct: 2437 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2496

Query: 965  KLIRRGRTKGLIKEHEACFSEEGC-----LYQLNHHMEVLRELCEELPSQKSQ-QEVKRL 1018
              + R R       H ACF          L +    M VL  L  +     +Q Q+V+ +
Sbjct: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 2556

Query: 1019 LKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
            LK++E + ++        H  L   A G     G ++ S ++           + + Q  
Sbjct: 2557 LKEFEARRQQ--------HEQLNEAAQGILTGPGDVSLSTSQ----------VQKELQSI 2598

Query: 1079 TEKAMEPTMKFSLAS------VLRPLQEESIMEKDYSASINSLLERYDTYRDI-LEHHLQ 1131
             +K +E T K +  S      +++  Q + +++ D S  + ++ +R      I  +    
Sbjct: 2599 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ-DLSEKVRAVGQRLSVQSAISTQPEAV 2657

Query: 1132 NNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPF 1191
              +   TS+  S+ ++    L  ++ + Q + +E      E + +  +L+  +  +  P 
Sbjct: 2658 KQQLEETSEIRSDLEQ----LDHEVKEAQTLCDELSVLIGE-QYLKDELKKRLETVALPL 2712

Query: 1192 VIKERDTLKERERELQMTLNT--RMESLETALRLVLPVEKASLLL-CGSDLPLHKMAIQG 1248
               E D   +R   LQ  L +  + + +   LR  L  +++     C     L ++  Q 
Sbjct: 2713 QGLE-DLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ- 2770

Query: 1249 FHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFD-LHAMQNIILKYKTQ 1307
                      Q     Q S+ +       +   G  +L  + P +    +QN +++ K  
Sbjct: 2771 ---------LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNH 2821

Query: 1308 FEGMNHR-----------VQRS-------EDTLKALEDFLASLRTAKLSAEPVTDLSASD 1349
            +E ++ +           +Q++       ED +  +ED  A +   +++ +PV   S+  
Sbjct: 2822 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 2881

Query: 1350 TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK 1409
               A  N   V+ +   + ++   A  L    +  +   +D + G + + + + +    K
Sbjct: 2882 RSKAMLNE--VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 2939

Query: 1410 LSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
                   G  EE T+  +  +   FKN E  K ++  + Q+           + K+ +K 
Sbjct: 2940 T------GSLEEMTQRLREFQES-FKNIE--KKVEGAKHQLEIFDALGSQACSNKNLEK- 2989

Query: 1470 LIRLDKVLDEYEEEKRHLQEMANSLPH-FKDGREKT-VNQQCQNTVVLWENTKALVTECL 1527
            L    +VL   E +  +L+     L     DG + + +  Q +     +   K  V    
Sbjct: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3049

Query: 1528 EQCGRVLELLKQYQ-NFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE 1586
                  LE + Q+    + + + L   ++ +  + A     ++L+ +I ++ +   + + 
Sbjct: 3050 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3109

Query: 1587 HLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALA 1646
                ++     C+++   L +  T +    ++E   +  +   + E+ +   E L   L 
Sbjct: 3110 LKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3166

Query: 1647 LWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL----QVHEQKTSEFSRRVAE 1702
              +  +     +++ T  A +   L  +   + E + ++L       +++      ++ +
Sbjct: 3167 RVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3226

Query: 1703 I----QFLLQSSEIPLELQVMESSI---------LNKMEHVQKCLTGESNCHALSGSTAE 1749
            +    Q L+QS+    ++Q +E  +         LNK    +     E+  H       +
Sbjct: 3227 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC-----GK 3281

Query: 1750 LREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQ-----KHSMILLENQI 1804
             ++ L+   + +  TE L+    P  +     K +  +Q++LQ+     K ++ +L+ + 
Sbjct: 3282 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3341

Query: 1805 GCL------------TPELSELKKQYESVSDLFNTKKSVLQDHF--SKLLNDQCKNFNDW 1850
            G +            T +L  L+ ++  +      ++  L+D    +K  ++  +  +D+
Sbjct: 3342 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3401

Query: 1851 FSNIKVNLKECFE-SSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAH 1909
             S  +  L       ++T K  +Q ++  +    +E   + + Q   + + +      A 
Sbjct: 3402 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3461

Query: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
               L   +   +    +++  C  +A  L+ +L       +D   +  WL   E+K   +
Sbjct: 3462 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 3521

Query: 1970 EEPGEKTELF----CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTL 2025
                 K ++        LA   E       ++ ++K      ++    E   + ++   +
Sbjct: 3522 FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 3581

Query: 2026 LRQLSEIE-EEDKLLPTEDQS------FNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
              + ++I     K L T +Q+      F     ++  W++E++E L    +S G+ P  E
Sbjct: 3582 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGE 3638

Query: 2079 RI----QKIKEIILLKPEGDARIETIMKQAESSEAPL----------VQKTLTDISNQWD 2124
            +I    Q+ KE+     E    ++T+    E S A L          + K ++D + Q+ 
Sbjct: 3639 QIPQFQQRQKELKKEVMEHRLVLDTVN---EVSRALLELVPWRAREGLDKLVSDANEQYK 3695

Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKI 2184
                     +   +  +   ++Y Q+ +     + E K+K  A   ++    +  AQL++
Sbjct: 3696 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 3755

Query: 2185 YKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD-SVQN 2243
             K F          + EL S  + +       +  EE    ++   ESL+QQ +  S+ N
Sbjct: 3756 QKAFSIDIIRHKDSMDELFSHRSEIFG-----TCGEEQKTVLQEKTESLIQQYEAISLLN 3810

Query: 2244 LDGHVREHDSYQVCVTDLNTTLDNFS------KEFVSFSDKP-VDQIAVEEKLQKLQELE 2296
             + + R   + QV V     T +  S      +  ++    P +D   + ++ +++++L 
Sbjct: 3811 SERYARLERA-QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 3869

Query: 2297 NRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEME-- 2354
              ++     + K+L +   +K+     G+ + +        K +  EN  A  K+E+   
Sbjct: 3870 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE--------KYQKAENMYAQIKEEVRQR 3921

Query: 2355 --CCLNSILKSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
                  ++ +S + TE   K   P  E  +  +S ++      A V+K+ E    NK + 
Sbjct: 3922 ALALDEAVSQSTQITEFHDKIE-PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSAT 3980

Query: 2411 VEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK-- 2468
            VE+   +     + E++K   +E  +   Q    +L      ++L+++   +  ++A+  
Sbjct: 3981 VELEKLQP----SFEALKRRGEEL-IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4035

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            +  IK L+  E   K       L       Q + + L++             +++   E 
Sbjct: 4036 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-------PGIDPSIIKQQVEA 4088

Query: 2529 LAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHV 2588
               ++     L  + E +++   D +    + +K    + K  D + N    WENL+   
Sbjct: 4089 AETIKEETDGLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNNA---WENLNKTW 4143

Query: 2589 TDMDKKLLESQIKQLEHG------WEQVEQQIQKKYSQQVVEYDEFTTL--MNKVQDTEI 2640
             +  +KL ++    +++       ++ ++  + K  +   V  D  T    +N++++ ++
Sbjct: 4144 KERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV 4203

Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
             + QQQ  ++                               L  Q EL +K+   E ++ 
Sbjct: 4204 EVYQQQIEMEK------------------------------LNHQGELMLKKATDETDRD 4233

Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKC-----DIRNKMKETILWAKNLLGELNPSIP 2755
             + + +  LK  WE L       +++++         ++ ++E + W  +    L+   P
Sbjct: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293

Query: 2756 LLPDDILSQIRKCK--VTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRN 2813
            +  D  + ++   K  V  + +LA Q +VE++ +   + + S    + S L + LE +  
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353

Query: 2814 QYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAA---TEAEL 2870
             ++ ++ K+ +R QQL+  L++   F + I  F L +   E+ +     T     T  E 
Sbjct: 4354 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQ 4413

Query: 2871 KHHHVTLEASQKELQEI----------------DSGISTHLQELTNIYEELNVFERLFLE 2914
               H+ L +  K  +E                 DSG  +  ++   + E+        +E
Sbjct: 4414 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4473

Query: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSA----LQEEADSIQRNELLLN 2970
            ++   L+   N    F QN+  E  + +    Q     S     L      I+ +++  N
Sbjct: 4474 ERKSKLEEALNLATEF-QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 4532

Query: 2971 QEVNKGVKEEIYNLKDRLTAIKCCILQ--VLKLKKVFDYIGLNWDFSQLDQLQTQVFEKE 3028
             EVN   +++I  L      +K    +  V+ +K +   +   W+     ++  +  E+ 
Sbjct: 4533 -EVNAH-RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE-----KVVQRSIERG 4585

Query: 3029 KELEEKIKQLDTFEEEHGKYQALLSKMRA--------------IDLQIKKMTEVVLKAPD 3074
            + L++  K+   F E   K    L    +              I LQ+ K  E       
Sbjct: 4586 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 4645

Query: 3075 SSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLY 3134
              P     +  I + R  K K L  E  +KL+    F    ++K       + E   KL 
Sbjct: 4646 KQPV---YDTTIRTGRALKEKTLLPEDSQKLDN---FLGEVRDKWDTVCGKSVERQHKLE 4699

Query: 3135 KVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEA 3194
            + L           L      D L+  +  L +++ QL +   ++ ++  + N  D  + 
Sbjct: 4700 EAL-----------LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748

Query: 3195 FQEQVWAEMCSIKAVTAIEKQREENS-SEASDVETKLREFE---DLQMQLNTSIDLRTNV 3250
            FQ+++     +++ +    ++  ENS  + + V+ +L+E     D   +L+ S   R   
Sbjct: 4749 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR--- 4805

Query: 3251 LNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP-------LRKQEEL 3303
            L  A +    +++ V   +E ++  E   + +R  + +  E+L+         ++K EE 
Sbjct: 4806 LEQALKQAEVFRDTVHMLLEWLSEAEQ-TLRFRGALPDDTEALQSLIDTHKEFMKKVEEK 4864

Query: 3304 ESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC 3363
               V     + E +  +  P+    +++ +  + ++   +    K  +   E  L     
Sbjct: 4865 RVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 4924

Query: 3364 YRKMEEDIYTNLSKMETVLGQ-SMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
              ++ E++   +   ET L Q     +P       + +++ KAL++   +  EE+ +
Sbjct: 4925 NAELLEELLAWIQWAETTLIQRDQEPIP-------QNIDRVKALIAEHQTFMEEMTR 4974



 Score =  108 bits (269), Expect = 2e-22
 Identities = 158/821 (19%), Positives = 326/821 (39%), Gaps = 59/821 (7%)

Query: 4667 SVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYA--------LLQEVYKLEDVLDS 4718
            +V +QL +   + VE+   +  + KL  +GE L L  A        + + + +L+ + ++
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE-LMLKKATDETDRDIIREPLTELKHLWEN 4248

Query: 4719 MWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIEN 4778
            +   +  R  +L    +   Q    L+ ++  +   +E L          KV ++ ++  
Sbjct: 4249 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV-IEVELAK 4307

Query: 4779 HKVFFQKLVADMLLIQAYS--------------AKILPSLLQNRETFWAEQVTEVKILEE 4824
            H V    ++A    ++  +              A  L S L+     W   + +    EE
Sbjct: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT---EE 4364

Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQI 4884
            + +Q    LQ       E ++    L +    L ++ P+  L E   E+L   +  Y Q+
Sbjct: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4424

Query: 4885 KRNIGGKHARLYQTLNEGKQLVA----SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
            K     K     Q L++G+ ++     S S  + E  +A LE++W  ++ K++    +L+
Sbjct: 4425 K----AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4480

Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
              L     +     +   WL  ++ +LN     SL     L+T+ S I     F+ EV+ 
Sbjct: 4481 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL----ILNTVLSQIEEHKVFANEVNA 4536

Query: 5001 KSSLKTAVISIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
                   +   GNQL  L ++ D   ++  L   + +W  ++ +  +    L   +    
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596

Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF-- 5117
               +A  ++I W+ + E     E  +   +   ++K  L KHKEF+  +  KQ + D   
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 4654

Query: 5118 -VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
               ++L + +    +S++ +       LGE+  +W  V G    +   LE+ L    +  
Sbjct: 4655 RTGRALKEKTLLPEDSQKLD-----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 4709

Query: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDI-ENQLAIKSKALDELKQSYLT 5235
            + +Q L +WL   E +L   Q     + +   L+D   + + +L  ++  +  LK+S   
Sbjct: 4710 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRE 4769

Query: 5236 LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIR 5295
            L   +     D  + +    Q+ S+    V +L  S QS L++     +++ +   M + 
Sbjct: 4770 LIENS----RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825

Query: 5296 FWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEII 5355
            +   +  ++  +     L    E LQSL D  +      E+ +  +     +   +  + 
Sbjct: 4826 W---LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 4882

Query: 5356 EEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS 5415
               C  T K W  + +A  +++       Q     + +   A A L ++   + Q A  +
Sbjct: 4883 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 4942

Query: 5416 MSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
            +   +  E +P  +  +K L  + Q   E   +    +DR+
Sbjct: 4943 LIQRD-QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982



 Score =  104 bits (260), Expect = 3e-21
 Identities = 616/3464 (17%), Positives = 1308/3464 (37%), Gaps = 549/3464 (15%)

Query: 605  TKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLV-- 662
            TKKE++ E   +T   +  +H      G+ L E         IS++L  LNK +  L   
Sbjct: 1476 TKKEQVSEA-IKTSQIFLAKH------GHKLSEKEK----KQISEQLNALNKAYHDLCDG 1524

Query: 663  SKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKH 722
            S  QL+     +  + +Q T     N   ++ +    +       L         AG + 
Sbjct: 1525 SANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERAL---------AGHQG 1575

Query: 723  EKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKG--SMF 780
                ++ +   K   D++ L   ++       +V+   D++  MEE+   L  +   ++ 
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVK--DIEGFMEENQTKLSPRELTALR 1633

Query: 781  DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI--NVVKLIAALKNLT 838
            ++L    E    +  +   +Q+  +  +T+ LQ + +++K   ++  N  K+ A L  +T
Sbjct: 1634 EKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVT 1693

Query: 839  DVSPDLDIRLKMEESQKELESYMMRAQQL------LGQRESPGELI-------SKHKEAL 885
             V       L      ++L    +    L      +G  ++P +L        ++H+E L
Sbjct: 1694 SVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELL 1753

Query: 886  -----IISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWES--LHHELSL-YV 937
                  I  T+S   +L   ++  +N+T + +  L++K  ++  ++ +     E  L  V
Sbjct: 1754 SQQQNFILATQSAQAFL---DQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810

Query: 938  QQLKIDIEKGKLSDN------ILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEE----- 986
            Q L+ +++K  L D+      + + EK++    K      T   + + +  FSE+     
Sbjct: 1811 QTLQDELQKF-LQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869

Query: 987  GCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG 1046
            G L  +    + + ++       K   E+  L+KD        LK A+E +  L      
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK-------LKDATERYTALHSKCTR 1922

Query: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDN--QPSTEKAMEPTMKFSLASVLRPLQEESIM 1104
               +   +       G  H     A S      + E  +E  +  ++AS    LQE+   
Sbjct: 1923 LGSHLNMLL------GQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 1976

Query: 1105 EKDYSASINSLLERYDTYRDILEHHLQNNKF-RITSDFSSEEDRSSSCLQAKLTDLQVIK 1163
             K                 ++ EH +   K  ++  D    E   +        D + ++
Sbjct: 1977 TKQLQ-------------EELAEHQVPVEKLQKVARDIMEIEGEPAP-------DHRHVQ 2016

Query: 1164 NETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRL 1223
              TD+    F+ +S  L              ER +L ++      ++    ESLE+ L+ 
Sbjct: 2017 ETTDSILSHFQSLSYSLA-------------ERSSLLQKAIAQSQSVQ---ESLESLLQS 2060

Query: 1224 VLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGN 1283
            +  VE+    L G  +      +    L    ++ Q +   + S+    E+  R  E  +
Sbjct: 2061 IGEVEQN---LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETAD 2117

Query: 1284 FVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKAL--------------EDFL 1329
                 +       +Q  + +   +FE +  + Q  E +LK L              + F+
Sbjct: 2118 STTAAV-------LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2170

Query: 1330 ASLRTAKLSA-EPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSF 1388
             +      S  +P  D++    Q+ QE  L +++++  +  ++     L  C   LD+  
Sbjct: 2171 ENKSRMLASGNQPDQDITHFFQQI-QELNLEMEDQQENLDTLEHLVTELSSCGFALDL-- 2227

Query: 1389 KDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQS 1448
                      C++     +++   T    +Q+   E  K   +C  + +E  K ++  Q 
Sbjct: 2228 ----------CQHQDRVQNLRKDFTE---LQKTVKEREKDASSCQEQLDEFRKLVRTFQK 2274

Query: 1449 QISKIGLKDP---TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTV 1505
             + +     P   T  + K  +K +  L  +LD++  +   ++E+               
Sbjct: 2275 WLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEI------------NCK 2322

Query: 1506 NQQCQNTV--VLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQAS 1563
                +N +  +   +++      L   G  +  +  Y   K +  T IQ + S ++L+  
Sbjct: 2323 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL--TEIQCDMSDVNLKYE 2380

Query: 1564 YMG------KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFE 1617
             +G      +E+L+  +  +E V +E N  L+ ++   +V K++    +  KT E    +
Sbjct: 2381 KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKT-ETVKAQ 2439

Query: 1618 KEANIIVDRWLDINE-KTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTE 1676
             E+N      L+ N  K +   E L   L  +      +N    W  K +Q+ EL+   E
Sbjct: 2440 AESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAEN----W--KKIQE-ELNSRWE 2492

Query: 1677 EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTG 1736
                R  E     +++  E +  +A      Q++E  L   +ME  ++            
Sbjct: 2493 ----RATEVTVARQRQLEESASHLA----CFQAAESQLRPWLMEKELM------------ 2532

Query: 1737 ESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHS 1796
                    G    L  D +    Q    + +LK            +L E  Q IL     
Sbjct: 2533 -------MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQH--EQLNEAAQGILTGPGD 2583

Query: 1797 MILLENQIGCLTPELSELKKQYESVSDLFNTKKS------VLQDHFSKLLNDQCKNFNDW 1850
            + L  +Q+     EL  + +++  ++D  N++ S      V    + +LL D  +     
Sbjct: 2584 VSLSTSQV---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640

Query: 1851 FSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHV 1910
               + V      +    K+ +E+  +  SD   LE  + ++K+  ++   +   + + ++
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEAQTLCDELSVLIGEQYL 2697

Query: 1911 K-ELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
            K EL   L      L+ +E +   R   L+ +L    + Q     LR WL +++ +    
Sbjct: 2698 KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKN 2757

Query: 1970 EEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQL 2029
                 K E   Q+  ++ E+F+     ++   E    E E +++      ++ +TL  QL
Sbjct: 2758 CPISAKLERL-QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEK-RTLQNQL 2815

Query: 2030 SEIEE--EDKLLPTED------------QSFNDLAHDVIHWIKEIKESLMVLNSSEGKMP 2075
             E++   E+    T D            Q +     D++ WI++ K  +  L  +   + 
Sbjct: 2816 VELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQ 2875

Query: 2076 LEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLS 2135
            LE  + + K ++    +  + +E +   A+     L+  +  D     D    +     +
Sbjct: 2876 LESSLLRSKAMLNEVEKRRSLLEILNSAADI----LINSSEADEDGIRDEKAGINQNMDA 2931

Query: 2136 HQEKLLLEGEKYLQSKE-DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIY--------- 2185
              E+L        Q+K   L  M   L++ QE+   ++  ++  K QL+I+         
Sbjct: 2932 VTEEL--------QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS 2983

Query: 2186 KKFLKKAQDLTSLLKELKSQGNYLLECTKN-----------------PSFSEEPWLEIKH 2228
             K L+K +    +L+ L+ Q +YL   T+                     +++ +LE+K 
Sbjct: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3043

Query: 2229 LHESLLQQLQDSVQNLDG-HVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEE 2287
               S    +++ ++ +   H R  + +   + DL+  LD              D  +++ 
Sbjct: 3044 RVNSGCVMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAI-------GRDTDSLQS 3095

Query: 2288 KLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLA 2347
            +++ ++   N++ +    ++   A  + + +   ++    +K ++++L  +   L  R  
Sbjct: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3155

Query: 2348 SAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINK 2407
            + ++++E  L  +    R  +     T    E +A   V  +  E   + +   D+++ +
Sbjct: 3156 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE--IINQQLADFKMFQ 3213

Query: 2408 DSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEA 2467
               V+    K   +N                +Q+   + D       +EEI   +  L  
Sbjct: 3214 KEQVDPLQMKLQQVNGLGQ----------GLIQSAGKDCDVQGLEHDMEEINARWNTLN- 3262

Query: 2468 KKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLL------QALITLKKNKESQYCV 2521
            KK A +  +  E L         LH  G     L+ LL      + LI  +K   ++Y V
Sbjct: 3263 KKVAQRIAQLQEAL---------LH-CGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3312

Query: 2522 LR-DFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            ++   QE     +  ++ LL D+++  V  L +          +A  EK    L +L+ +
Sbjct: 3313 VKAQIQE-----QKLLQRLLDDRKAT-VDMLQAEGGRIAQSAELADREKITGQLESLESR 3366

Query: 2581 WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI 2640
            W  L +      K+L +  +             + K++ +      +F ++  K      
Sbjct: 3367 WTELLSKAAARQKQLEDILV-------------LAKQFHETAEPISDFLSVTEKKLANSE 3413

Query: 2641 SLQQQQQHLQ---LRLKSPEERAGNQSMIALTTDL-QATKHGFSVLKGQAELQMKRIWGE 2696
             +  Q   +Q   +R K+ EE   N +     TD+ QA K G S         +  +   
Sbjct: 3414 PVGTQTAKIQQQIIRHKALEEDIENHA-----TDVHQAVKIGQS---------LSSLTSP 3459

Query: 2697 KEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKM-----KETILWAKNLLGELN 2751
             E+  L + I++L+ ++  ++         + +     ++      E + W   +  +L+
Sbjct: 3460 AEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLS 3519

Query: 2752 PS-IPLLPDDILSQIRKCKVT-HDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLE 2809
               +     D+L +     +  ++ I+ R+++V+   +  +  +   T  E   +   L+
Sbjct: 3520 SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLD 3579

Query: 2810 DLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAE 2869
             ++ +Y  + + S++  + LE   +  + F +   +    ++E E      + T+  ++ 
Sbjct: 3580 GIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE----ELATSGGQSP 3635

Query: 2870 LKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLE-------DQLKNLKI 2922
                    +  QKEL++        + E   + + +N   R  LE       + L  L  
Sbjct: 3636 TGEQIPQFQQRQKELKK-------EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 3688

Query: 2923 RTNRIQRFIQNTC----NEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVK 2978
              N   + + +T     +E++  I+  +Q+ +   A        +R  + L       ++
Sbjct: 3689 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP-----IR 3743

Query: 2979 EEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKE-LEEK--- 3034
             E      +L   K   + +++ K   D +     FS   ++     E++K  L+EK   
Sbjct: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDEL-----FSHRSEIFGTCGEEQKTVLQEKTES 3798

Query: 3035 -IKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEK 3093
             I+Q +     + +  A L + + +   + +  E   +      E+R L AQ+ S  I+ 
Sbjct: 3799 LIQQYEAISLLNSERYARLERAQVL---VNQFWETYEELSPWIEETRALIAQLPSPAIDH 3855

Query: 3094 AKCLCDEIIKKLNENKTFDDSFKEKE-----ILQI-----KLNAEENDKL---YKVLQNM 3140
                 +++ ++  E +   +S  E +     +L+I     +LN EE + +   Y+  +NM
Sbjct: 3856 -----EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM 3910

Query: 3141 VLELSPK------ELDEKNCQ--------DKLETSLHVLNQIKSQLQQPLLINLEIKHIQ 3186
              ++  +       LDE   Q        DK+E  L  L  + S+L+ P LI  E+  I+
Sbjct: 3911 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 3970

Query: 3187 NEKDNCEAFQEQVWAEMCSIK-AVTAIEKQREE--NSSEASDVETKLREFEDLQMQLNTS 3243
                 C +  +    E+  ++ +  A++++ EE    S+ +D +   +E +D   +L+  
Sbjct: 3971 E----CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD---KLDQM 4023

Query: 3244 IDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP------L 3297
            +    ++   A E   ++ + +  A +    + A++   + D  +    LE P      +
Sbjct: 4024 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK-DTQDIVHDLESPGIDPSII 4082

Query: 3298 RKQEELESTVAHIQD-LTEKL--------------GMISSPEAKLQLQYTLQELVSKNSA 3342
            ++Q E   T+    D L E+L              G    PE +  +        + N  
Sbjct: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142

Query: 3343 MKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQ 3402
             KE  +  E   +  ++     + M + +   + K+ T     M  +        ++L +
Sbjct: 4143 WKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-----MPPVGTDLNTVKDQLNE 4197

Query: 3403 SKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEM 3462
             K     +   + E+ KL     L+  + T+     +++           L E    WE 
Sbjct: 4198 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE---------PLTELKHLWEN 4248

Query: 3463 WCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVE 3522
              E++         ++E   + L   Q  L E+        TEEL +    +    + +E
Sbjct: 4249 LGEKIAHR----QHKLEGALLALGQFQHALEELMSW--LTHTEELLDAQRPISGDPKVIE 4302

Query: 3523 ----KQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKL-------LQKV 3571
                K  +L   +L    +++ V ++   +    A  + +S++ R   +       LQK 
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362

Query: 3572 QKNKELVQTEIQERHSFTKEI----IALKNFFQQTTTSFQNMAFQDHP-EKSEQFEELQS 3626
            ++ ++ +Q+ +Q+   F  EI    + L     Q + S       +   E+ +   EL S
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422

Query: 3627 ILKKGKLTFENIMEKLRI------------KYSEMYTIVPAE---IESQVEECRKALEDI 3671
             LK  + T+  +++K R+            K  +   ++  +   + S++EE +  LE  
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE-- 4480

Query: 3672 DEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKS------KNIEKAQEIQKKMWD 3725
                  E L  +  +  +  ++E  N L   E+ L   S        +    E  K   +
Sbjct: 4481 ------EALNLATEF--QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 4532

Query: 3726 ELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ-QYQQVSQRAECRTSQLNKAT 3784
            E++    ++ ELD     +      Q    + NL++  Q ++++V QR+  R   L+ A 
Sbjct: 4533 EVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 4592

Query: 3785 VKMEEYSDLLKSTEAWIENT-SHL-----LANPADYDSLRTLSH 3822
             + +++ +  K    W+E+  SHL     ++N  D   L+   H
Sbjct: 4593 KRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH 4636



 Score =  103 bits (258), Expect = 5e-21
 Identities = 340/1847 (18%), Positives = 726/1847 (39%), Gaps = 248/1847 (13%)

Query: 4654 TSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLE 4713
            T+L++ L++   Q  A Q    +    + E  E+  + L+ E E+      L +   K++
Sbjct: 1630 TALREKLHQAKEQYEALQ---EETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKID 1686

Query: 4714 DVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA----HGHLKQTKSK 4769
             +LD  W         ++S   +  Q    L GM +L     EK A     G++   ++ 
Sbjct: 1687 ALLD--W---------VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAP 1735

Query: 4770 VALQAQIENHKVFFQKLVADM--LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSR 4827
              L  Q E  K   Q+L++     ++   SA+       +  T   +Q+ + K+ E K +
Sbjct: 1736 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQ 1795

Query: 4828 QCGM----------------KLQSLLQKWEEFDENYASLEKDLEIL------ISTLPSVS 4865
                                +LQ  LQ  +EF+      EK+LE +        TLPS+ 
Sbjct: 1796 YSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLL 1855

Query: 4866 LVEETEERLVERISFYQQIKRNI---GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLE 4922
               + +    E +  ++   R +   G K   +  +  EGK+   S     ++ ++    
Sbjct: 1856 ---KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE--PSEIGNLVKDKLKDAT 1910

Query: 4923 EQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLD 4982
            E++ +L+ K       L  LL     +   +D L  W+++ +   N  K  S  V+ D  
Sbjct: 1911 ERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE--ANVEKLLSDTVASDPG 1968

Query: 4983 TIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLL-----------HLKETDTA------T 5025
             ++  +    +  +E+ E       +  +   ++           H++ET  +      +
Sbjct: 1969 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2028

Query: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQL-----QMEKLPSRKAITEMISWMNNVEHQTS 5080
            L  SLA+        I Q   +QE L  L     ++E+    K ++ + S +      T+
Sbjct: 2029 LSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATN 2088

Query: 5081 ---DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESK---- 5133
                +D     SS    + ++ +  E            D    ++LQ    +V  +    
Sbjct: 2089 MKLKQDIARQKSSLEATREMVTRFME----------TADSTTAAVLQGKLAEVSQRFEQL 2138

Query: 5134 ---RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLES-------ITESENKIQILN 5183
               + E+    + L      +  + G L + +++  ++L S       IT    +IQ LN
Sbjct: 2139 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN 2198

Query: 5184 NWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELKQSYLTLESGAVP 5242
              +E Q+E L TL+   + +S     LD CQ  +         +  L++ +  L+     
Sbjct: 2199 LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR--------VQNLRKDFTELQKTVKE 2250

Query: 5243 LLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEH 5302
              +D +S  ++L + R  V T    LK +  S+            E +M        +EH
Sbjct: 2251 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP---------TETSMSAKELEKQIEH 2301

Query: 5303 SKPVV-------LSLETLRCQVENLQSLQDE--AESSEGSWEKLQEVIGKLKG------L 5347
             K ++         +E + C+  +L++L  E  A  S+G    +   +G   G       
Sbjct: 2302 LKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHT 2361

Query: 5348 CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAK 5407
            C  + E I+    + + ++ ++   + ++ +  Q++L         H EA + L+  E+K
Sbjct: 2362 CKDLTE-IQCDMSDVNLKYEKLGGVLHERQESLQAIL---NRMEEVHKEANSVLQWLESK 2417

Query: 5408 FQQLANI-SMSGNNLAEILPPA-------LQDIKELQHDVQKTKEAFLQNSSVLDRLPQP 5459
             + L ++ +MS     E +          L ++++    +QK KEA    + +L   P  
Sbjct: 2418 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL---AGLLVTYPNS 2474

Query: 5460 AESSTHMLLPGPLHS-LQRAAYL----EKMLLVKANE---FEFVLSQFKDFGVRLESLKG 5511
             E+     +   L+S  +RA  +    ++ L   A+    F+   SQ + + +  E + G
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534

Query: 5512 LIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS---------LKLPLSD 5562
            ++     + + L+ Q K+     L    A   Q    E LNE +         + L  S 
Sbjct: 2535 VLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQH---EQLNEAAQGILTGPGDVSLSTSQ 2590

Query: 5563 VAVKTLQNMNRQWIRATATALERCSEL-QGIGLNEKFLYCCEKWIQLLEKIEEALKVDVA 5621
            V  K LQ++N++W+  T     R S++ Q I  + ++    +   + +  + + L V  A
Sbjct: 2591 VQ-KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA 2649

Query: 5622 -NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI-TEFSKLTD 5679
             ++ PE ++QQ       +E+  +    D  V ++  L D   +    +++  E  K  +
Sbjct: 2650 ISTQPEAVKQQLEE---TSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE 2706

Query: 5680 RWQNAVQGVRQRKGD----VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLY 5735
                 +QG+     D    +   +   Q F    + L  +L D      A        L 
Sbjct: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL-DDKQSQQAKNCPISAKLE 2765

Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDL-KTKESVGRRISQLQDSWKDM 5794
            + +S + E +  +    +   +  + +  GE LLL+    + K ++  ++ +L++ W+++
Sbjct: 2766 RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL 2825

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSE------DPLPELHEDLHNEK 5848
              + A+   + +  ++   + +  +++L   ++  KA+        DP+ +L   L   K
Sbjct: 2826 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSK 2884

Query: 5849 ELIKELEQ---------SLASWTQNLKE-----LQTMKADLTRHV--LVEDVMVLKEQIE 5892
             ++ E+E+         S A    N  E     ++  KA + +++  + E++      +E
Sbjct: 2885 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLE 2944

Query: 5893 HLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMI 5952
             + ++  +        ++++E   +   +F+    + C+      NK L+      +E++
Sbjct: 2945 EMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS------NKNLEKLRAQ-QEVL 2997

Query: 5953 EKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-----EIDDKLNKINDRWQHLF 6007
            + L+   ++ +  F++  ++    G    +  +++  A     E+  ++N      ++  
Sbjct: 2998 QALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKL 3056

Query: 6008 DVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ 6067
            + IG    +++E F+ +  LD  +  +   + R    L   +       ++++  L +  
Sbjct: 3057 EGIGQFHCRVREMFSQLADLDDELDGMGA-IGRDTDSLQSQI-------EDVRLFLNKIH 3108

Query: 6068 DLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMER 6127
             L+ DIE   A        C  +L +        +   +++   +L+++   +      R
Sbjct: 3109 VLKLDIEASEAE-------CRHMLEEE----GTLDLLGLKRELEALNKQCGKLTERGKAR 3157

Query: 6128 RMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQR-QI 6186
            + ++E T    + F        D   +AE   A             ++L  F+ FQ+ Q+
Sbjct: 3158 QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQV 3217

Query: 6187 HERLTQLELINKQYRRLARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
                 +L+ +N   + L +    D     L+  + E N RW+ L ++V   + +L+    
Sbjct: 3218 DPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALL 3277

Query: 6246 QREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI---TLNTNK--I 6300
               +F+   E +L WL + +  + N +      A+ K+ +    +Q++    L+  K  +
Sbjct: 3278 HCGKFQDALEPLLSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRLLDDRKATV 3334

Query: 6301 DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
            D L   G ++ Q +E  D   I  +LE L     E+  + +   ++L
Sbjct: 3335 DMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3381



 Score = 97.4 bits (241), Expect = 4e-19
 Identities = 130/690 (18%), Positives = 276/690 (40%), Gaps = 60/690 (8%)

Query: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
            G++ + L    + +  C E        R + L++ L   + + +EI+    +L + ++ L
Sbjct: 4338 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQL 4397

Query: 4657 QQSLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
              S     G  ++  EQL        +L+  E    +L D+G  + L         K E 
Sbjct: 4398 SAS-KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQ 4456

Query: 4715 ---VLDSMWGMLRARYTELSSPF------VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
               +L+  W ++ ++  E  S         TE Q    LQ  +  + + ++ L   ++  
Sbjct: 4457 SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS--LQEFINWLTLAEQSL---NIAS 4511

Query: 4766 TKSKV--ALQAQIENHKVFFQKLVADM--------------LLIQAYSAKILPSLLQNRE 4809
              S +   + +QIE HKVF  ++ A                 L Q     ++ +LL + +
Sbjct: 4512 PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQ 4571

Query: 4810 TFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE 4869
            + W + V       ++S + G  L    ++ ++F E +  L   LE   S L S   +  
Sbjct: 4572 SRWEKVV-------QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 4624

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE----LEGQIAKLEEQW 4925
              +++  ++S +++ ++ +GGK      T+  G+ L      PE    L+  + ++ ++W
Sbjct: 4625 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 4684

Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
             ++  K     H+L+  L     +      L  WL   +  L     +   V  DLD + 
Sbjct: 4685 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL----AEDQPVHGDLDLVM 4740

Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLP 5045
            + ++    F KE+ +++     +   G +L+     DT  ++  L +   +W  +     
Sbjct: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800

Query: 5046 DIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFR 5105
              Q +L Q   +    R  +  ++ W++  E       ++  P     ++ L+  HKEF 
Sbjct: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL--PDDTEALQSLIDTHKEFM 4858

Query: 5106 MEMDYKQWIVD-FVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQH 5164
             +++ K+  V+  V    + L+ C  +      T     +  +  ++  V     +  Q 
Sbjct: 4859 KKVEEKRVDVNSAVAMGEVILAVCHPDC----ITTIKHWITIIRARFEEVLTWAKQHQQR 4914

Query: 5165 LEQLLESITESENKIQILNNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAI 5221
            LE  L  +  +   ++ L  W++  E  L    +   P+++  V+ L+ + Q    ++  
Sbjct: 4915 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 4974

Query: 5222 KSKALDELKQSY--LTLESGAVPLLEDTAS 5249
            K   +D + ++Y    +E    P +E + S
Sbjct: 4975 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRS 5004



 Score = 83.2 bits (204), Expect = 8e-15
 Identities = 385/2184 (17%), Positives = 812/2184 (37%), Gaps = 318/2184 (14%)

Query: 286  KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNE--EK 343
            KD     ++ Q  V+D + W+   K K+ +L    +     +  +SLL      NE  ++
Sbjct: 2837 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKR 2893

Query: 344  KSFLDVLSIKRDL----DELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL 399
            +S L++L+   D+     E D+D ++  +A  G++  ++A   +L  A    L +    L
Sbjct: 2894 RSLLEILNSAADILINSSEADEDGIRDEKA--GINQNMDAVTEELQ-AKTGSLEEMTQRL 2950

Query: 400  QEVEELMDEDLSASQDHSQAVTLIQ------------EKMTLFKSLMDRFEHHSNILLTF 447
            +E +E         +     + +              EK+   + ++   E   + L  F
Sbjct: 2951 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3010

Query: 448  ---------ENKDEN---HLPLVPPNKLEEMKRRINN---ILEKKFILLLEFHYYKCLVL 492
                     +  D +   H   V   +  E+K+R+N+   ++E K   + +FH     + 
Sbjct: 3011 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3070

Query: 493  GLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLAR-LDTSFQKCGEIYKN--- 548
              + ++  +LD         +S++  +ED   F+ +   L   ++ S  +C  + +    
Sbjct: 3071 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3130

Query: 549  -----LAGECQNINKQYMMVKS-----------------DVCMYRKNIYNVKSTLQKVLA 586
                 L  E + +NKQ   +                   D     K + +  +  ++  A
Sbjct: 3131 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA 3190

Query: 587  C-WA--TYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVV 643
              W   T VE +    A F+  +KE++  +  +      L    +  AG        DV 
Sbjct: 3191 LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQ 3245

Query: 644  GSSISKELRRLNKRWRKLVSKT-----QLEMNLPLMIKKQD--QPTFD---NSGNILSKE 693
            G  +  ++  +N RW  L  K      QL+  L    K QD  +P      ++  +++ +
Sbjct: 3246 G--LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3303

Query: 694  EKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTG----QLKVAKDVEKLIGQVEIW 749
            +  + E+    +    +   Q +    K   +  +  G    Q     D EK+ GQ+E  
Sbjct: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363

Query: 750  EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESF----- 804
            E+    +L +     + ++ L+ ++     F E      D L +  + +++ E       
Sbjct: 3364 ESRWTELLSKA---AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3420

Query: 805  ----QHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQ---KEL 857
                Q +    L+  I+     V    VK+  +L +LT  +    +  K++  Q    E+
Sbjct: 3421 KIQQQIIRHKALEEDIENHATDVH-QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3479

Query: 858  ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
            +    R   LL Q  S   L  + +  ++         +L  VE+  ++V       +++
Sbjct: 3480 QDRCCRKAALLDQALSNARLFGEDEVEVL--------NWLAEVEDKLSSVF------VKD 3525

Query: 918  KSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIK 977
              +DV  +  + H  L+  +   K ++++     N   L KQ   E+ L+ + +  G+  
Sbjct: 3526 FKQDVLHRQHADHLALNEEIVNRKKNVDQA--IKNGQALLKQTTGEEVLLIQEKLDGIKT 3583

Query: 978  EH-EACFSEEGCLYQLNHHMEV--------------LRELCEELPSQKSQQEVKRLLKDY 1022
             + +   +    L  L    ++              LRE+ EEL +   Q      +  +
Sbjct: 3584 RYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 3643

Query: 1023 EQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGG------DPHSEAPFAKS--- 1073
            +Q+ + L K   E H  +  T    S+    +     R G      D + +         
Sbjct: 3644 QQRQKELKKEVME-HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 3702

Query: 1074 DNQPSTEKAMEPTMKFSLAS---------------VLRPLQEESIMEKDYSASINSLLER 1118
                  + A++ + ++  A+                L P++    +E+D + +   + + 
Sbjct: 3703 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----LEQDQTTAQLQVQKA 3758

Query: 1119 YDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISL 1178
            +    DI+ H     K  +   FS   +   +C + + T   V++ +T++  +++E ISL
Sbjct: 3759 FSI--DIIRH-----KDSMDELFSHRSEIFGTCGEEQKT---VLQEKTESLIQQYEAISL 3808

Query: 1179 KLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSD 1238
                         +  ER    ER    Q+ +N   E+ E    L   +E+   L+    
Sbjct: 3809 -------------LNSERYARLERA---QVLVNQFWETYE---ELSPWIEETRALIAQLP 3849

Query: 1239 LPLHKMAIQGFHLIDADRIYQH---LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLH 1295
             P           ID +++ Q    +R +++SIA+     ++L + G   LKEL+P +  
Sbjct: 3850 SPA----------IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP-QLKELNPEEGE 3898

Query: 1296 AMQNIILKYKTQFEGMNHRVQRS---------------------EDTLKALEDFLASLRT 1334
             ++    K +  +  +   V++                      E  L+ LE+  + LR 
Sbjct: 3899 MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRM 3958

Query: 1335 AKLSAEPVTDLSA--SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
              L    V  +    SD + A   T+ ++  +     +K + + L    +  D      E
Sbjct: 3959 PPLIPAEVDKIRECISDNKSA---TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4015

Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEE--FTEENKLLEACIFKNNELLKNIQDVQSQI 1450
              D       LD       +      + E  F +  +L E   +    LL  I+D Q  +
Sbjct: 4016 IQDK------LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069

Query: 1451 SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT-VNQQC 1509
              +         +K + ++   + +  D   EE   ++ +   L       EK  V +  
Sbjct: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129

Query: 1510 QNTVVLWENTKALVTECLEQCGRVLELLKQYQN-FKSILTTLIQKEESVISLQASYMGKE 1568
                  WEN      E LE+    ++   QYQ+  +++   L      + ++        
Sbjct: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4189

Query: 1569 NLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPP---FEKEANIIVD 1625
             +K ++ E++  K E  +    ++K+N      Q  L   K  +E       +    +  
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNH-----QGELMLKKATDETDRDIIREPLTELKH 4244

Query: 1626 RWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEE 1685
             W ++ EK       L  AL    +  +    +  W     + ++  +    D + ++ E
Sbjct: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304

Query: 1686 LQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME--SSILNKMEHVQKCLTGESNCHAL 1743
            L  H    ++     A ++ + ++    LE    +  SS+ +++E + +C   ES     
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW--ESVLQKT 4362

Query: 1744 SGSTAELREDLDQAK----------TQIGMTESLLKALSPSDSL------------EIFT 1781
                 +L+  L QA+           ++   ES L A  P+  L            E+++
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422

Query: 1782 KL---EEIQQQILQQKHSMILLENQIGC---LTPELSELKKQYESVSDLFNTKKSVLQD- 1834
            +L   EE   Q+L +   M+L  +  G        ++ L++++  VS     +KS L++ 
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4482

Query: 1835 -HFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLT-LEGRNSKIK 1892
             + +    +  + F +W +  + +L      S    +V  ++++   F   +     +I 
Sbjct: 4483 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 4542

Query: 1893 QVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDH 1952
            ++D     +K    K  V  + + LV  +   EK+      R + L+D+ ++  +  +  
Sbjct: 4543 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 4602

Query: 1953 RNLRKWLTNQEEKWKGMEEPGE----------KTELFCQALARKREQFESVAQLNNSLKE 2002
            + L  WL + E       E             K + F + L  K+  +++  +   +LKE
Sbjct: 4603 KKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE 4662

Query: 2003 YGFTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
                 E+   ++     + D++ T+  +  E + + +        F D    ++ W+ ++
Sbjct: 4663 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 4722

Query: 2061 KESL-----------MVLNSSEGKMPLEERIQKIKEII-LLKPEGDARIETIMKQAESSE 2108
            +  L           +V+N  +     ++ + K    + +LK  G   IE         +
Sbjct: 4723 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-----SRDD 4777

Query: 2109 APLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
               V+  L ++S +WD    L+ +  S  E+ L + E +  +   L   L E ++     
Sbjct: 4778 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 4837

Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE-CTKNPSFSEEPWLE-I 2226
             AL    +  ++ +  +K+F+KK ++    +    + G  +L  C  +   + + W+  I
Sbjct: 4838 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 4897

Query: 2227 KHLHESLLQQLQDSVQNLDGHVRE 2250
            +   E +L   +   Q L+  + E
Sbjct: 4898 RARFEEVLTWAKQHQQRLETALSE 4921



 Score = 75.5 bits (184), Expect = 2e-12
 Identities = 265/1481 (17%), Positives = 564/1481 (38%), Gaps = 291/1481 (19%)

Query: 5094 VKHLLQKHKEFRMEMDYKQWIVDF------------VNQSLLQLSTCDVESKRYE----- 5136
            V  LL   +E +M+++  +W  D             ++ S+ +L +   E++ YE     
Sbjct: 589  VYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQ 648

Query: 5137 --RTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILN---------NW 5185
               T +AE LG++  Q+ ++    + +++HL+ L + ++ +  ++  LN         +W
Sbjct: 649  NFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDW 708

Query: 5186 --------------------LEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKA 5225
                                LE +++  ++LQ    ++S++      Q +E   A     
Sbjct: 709  SDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK-QTVEAYSAAVQSQ 767

Query: 5226 LDELKQSYLTLE-------------SGAVPL------LEDTA------------SRIDEL 5254
            L  +KQ  L +E             S A  L      L+D+             SR+++L
Sbjct: 768  LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL 827

Query: 5255 FQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLY----DEVNMMTIRFWYCMEHSKPVVLSL 5310
             Q       Q+ Q K+S+ S++   K   QL     D V   TI      ++ +  +   
Sbjct: 828  LQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITIC 887

Query: 5311 ETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVN 5370
            +   C +E+         S    W+ +     +   + PSV  +I    ++  +  ++V 
Sbjct: 888  KNDECVLED--------NSQRTKWKVISPTGNE--AMVPSVCFLIPPPNKDAIEMASRVE 937

Query: 5371 QAIADQLQKAQSLLQLW-KAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPAL 5429
            Q+        Q ++ LW + + N     +    +++    Q  N       L ++   A 
Sbjct: 938  QSY-------QKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWN-------LEKLRSSAP 983

Query: 5430 QDIKELQHDVQKTKEAFLQNS------SVLDRLPQPAE----SSTHMLLPGPLHSLQRAA 5479
             +  ++  ++Q   E FLQ+S      SV DRL    E     +    L   + +  +  
Sbjct: 984  GECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEE 1043

Query: 5480 YLEKMLLVKANEFEFVLSQFKDFGV-RLESLKGLIMHEE---ENLDRLHQQE--KENPDS 5533
             + KM + +       L +++   V R++SL       +   +N  R+ +QE  +E+   
Sbjct: 1044 TVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQ 1103

Query: 5534 FLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIG 5593
              + + A++ +     H +  S  +P     +  L          +   L +   +  I 
Sbjct: 1104 LRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIV 1163

Query: 5594 LNEKFLYCCEKWIQLLEKIEEALKVDVA----------NSLPELLEQQKTYKMLEAEVSI 5643
             + +      K  ++    EE +  D++          + L ++ ++   + +L+ E++ 
Sbjct: 1164 RSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAK 1223

Query: 5644 NQTIAD--SYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQ 5701
             + +A+  S +T    L    ++E   E   + S+L +RW   +  +  R+ +++ +   
Sbjct: 1224 AKVVAEQMSRLTPERNL----DLERYQE---KGSQLQERWHRVIAQLEIRQSELESIQEV 1276

Query: 5702 WQDFTTSVENLFRFLTDTSHLLSAVK-GQERFS------LYQTRSLIHELKNKEIH---- 5750
              D+      L +++ +T+     +K GQ   S      L Q  +L  E++  +      
Sbjct: 1277 LGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQC 1336

Query: 5751 -------------FQRRRTTCALTLEAGEK-------LLLTTDLKTKESVGRR------- 5783
                         ++ +  T    +E+ +K       +L ++D  T+E +  R       
Sbjct: 1337 QKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALV 1396

Query: 5784 ------ISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVL--KAQSED 5835
                  +  + D+ + +E +   + ++ Q  VE       K+KEL   +  L    Q + 
Sbjct: 1397 TLTTQHVKYISDALRRLEEEEKVVEEEKQEHVE-------KVKELLGWVSTLARNTQGKA 1449

Query: 5836 PLPELHEDLHNEKELIKE--LEQSLASWTQNLKE-LQTMKADLTRH---VLVEDVMVLKE 5889
               E  E    EK ++++  L + L +  + + E ++T +  L +H   +  ++   + E
Sbjct: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISE 1509

Query: 5890 QIEHLHRQWEDLCLRVAIRKQEIEDRLNTWV----------VFNEKNKELCAWLVQMENK 5939
            Q+  L++ + DLC   A + Q+++ +L                +++ ++LC+W+ Q E  
Sbjct: 1510 QLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERA 1569

Query: 5940 VLQTADISIEEMIEKLQK------DCMEEI-NLFSENKLQLKQMGDQLIKASNKSRAAEI 5992
            +      + ++ +  LQK      D  ++I N  +     +K +   + +   K    E+
Sbjct: 1570 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 1629

Query: 5993 D---DKLNKINDRWQHLFDVIGSRVKKLKE--TFAFIQQLDKN------------MSNLR 6035
                +KL++  ++++ L +      K+L+E  T A  Q+ +K+            +  L 
Sbjct: 1630 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALL 1689

Query: 6036 TWLARIESE------------------LSKPVVYDVCD------------DQEIQKRLAE 6065
             W+  + S                   L K  + D  D            D++ +   A 
Sbjct: 1690 DWVTSVGSSGGQLLTNLPGMEQLSGASLEKGAL-DTTDGYMGVNQAPEKLDKQCEMMKAR 1748

Query: 6066 QQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSM 6125
             Q+L    +      +S     D   H+        E   +QQ    L  ++    A S 
Sbjct: 1749 HQELLSQQQNFILATQSAQAFLDQHGHN----LTPEEQQMLQQKLGELKEQYSTSLAQSE 1804

Query: 6126 ERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQ 6185
                +++      QKFL D+  FE WL+ +E+     +       +    LKR  +F   
Sbjct: 1805 AELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 1864

Query: 6186 IHERLTQLELINKQYRR-LARENR-------TDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            +      L  +    ++ L  EN        ++  + +K  + +  +R+  L  + T + 
Sbjct: 1865 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 1924

Query: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH-FSESDADDKMRQLNGFQQEITLN 6296
              L     Q  +F+ + +S+  W+   +    NVE   S++ A D      G  QE    
Sbjct: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACE---ANVEKLLSDTVASDP-----GVLQEQLAT 1976

Query: 6297 TNKIDQLIVFGEQLIQKSEPL--DAVLIEDELEELHRYCQE 6335
            T ++ + +   +  ++K + +  D + IE E    HR+ QE
Sbjct: 1977 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE 2017



 Score = 59.7 bits (143), Expect = 1e-07
 Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 32/258 (12%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
            WE +  +  H + K++  L    Q    +  + +WL  TE   E+L   +P S D + IE
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4302

Query: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
            + + +   +      ++A V +VN +  E L++ +  +++ L+SRL  ++  WE+     
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
            +     L+ +L Q Q FH   ++ LL L   +++   +  T        L E  RE +  
Sbjct: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG------GLPETAREQLDT 4416

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGH---------------GEDCIEAEEKVHVIEKKLK 6754
              EL     Q+   +E  N LL KG                 +     E+K HV+  K++
Sbjct: 4417 HMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4473

Query: 6755 QLREQVSQDLMALQGTQN 6772
            + + ++ + L      QN
Sbjct: 4474 ERKSKLEEALNLATEFQN 4491



 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 72/337 (21%), Positives = 139/337 (41%), Gaps = 22/337 (6%)

Query: 6524 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 6579
            IT Q      RW  + ++    + +++  L   +Q +     I+ +L  TE +L   + +
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415

Query: 6580 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
                + IQ+  +R K L+E ++  A D ++A+ +  ++SS     T   E   L  ++  
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3471

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6697
            L   +   Q         L Q+L   + F +    +L WLA  +++     V D K D  
Sbjct: 3472 LQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 3529

Query: 6698 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6757
             L     + + L +E+V R+  VD   +   +LL +  GE+ +  +EK+  I+ +   + 
Sbjct: 3530 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 3589

Query: 6758 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESR 6817
               S+ L  L+  +  A+   S  E  +G                  + T+ G+  T  +
Sbjct: 3590 VTSSKALRTLEQARQLATKFQSTYEELTGWLREVE----------EELATSGGQSPTGEQ 3639

Query: 6818 VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6854
            +P   + Q+     V+   L L  +  +   L  L+P
Sbjct: 3640 IPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 3676



 Score = 51.2 bits (121), Expect = 3e-05
 Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 8/234 (3%)

Query: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 6608
            Q  QQ      A   W+ +T+ +L  L   +   D    +L+V++    +I++  D+   
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772

Query: 6609 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
            L    +  S+ F      + T LQ +   L   +EA           L ++ +    F +
Sbjct: 3773 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE 3829

Query: 6669 LSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISN 6728
              + L  W+   + R   A +  P  D   L + + E+ QL + + E +P +D L +I  
Sbjct: 3830 TYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887

Query: 6729 SLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDE 6782
             L  + + E+    EEK    E    Q++E+V Q  +AL    + ++ +  F +
Sbjct: 3888 QLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 3940



 Score = 50.8 bits (120), Expect = 5e-05
 Identities = 45/199 (22%), Positives = 85/199 (42%), Gaps = 11/199 (5%)

Query: 6542 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 6601
            EL     ++  LQ+   D     +WL+++E ELE   M K  S  + +   +KR     +
Sbjct: 1806 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 1863

Query: 6602 AFDTYKALVVSVNVSSKEFLQTESP-----ESTEL----QSRLRQLSLLWEAAQGAVDSW 6652
               ++K  +  V +S ++ L  E+      E +E+    + +L+  +  + A        
Sbjct: 1864 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 1923

Query: 6653 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKE 6712
               L   L Q   F   + +L  W+ + +   +K       +DP  L E      QL++E
Sbjct: 1924 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 1983

Query: 6713 LVERQPQVDMLQEISNSLL 6731
            L E Q  V+ LQ+++  ++
Sbjct: 1984 LAEHQVPVEKLQKVARDIM 2002



 Score = 50.8 bits (120), Expect = 5e-05
 Identities = 48/216 (22%), Positives = 94/216 (43%), Gaps = 18/216 (8%)

Query: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            D+W+ +  + +  + K+++ L    Q    + A+  WL K E +L   +      D+   
Sbjct: 4682 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDL--- 4738

Query: 6590 ELRVKRLQEILKAFDTY----KALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 6645
               V  L +  K F          V  +  S +E ++    ++T ++ +L++LS  W+  
Sbjct: 4739 ---VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 4795

Query: 6646 QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRR 6704
                 S +  L Q+L Q + F      LL WL+ A+   R +  + D     ++L++  +
Sbjct: 4796 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 4855

Query: 6705 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6740
            E M   K++ E++  V+    +   +L   H  DCI
Sbjct: 4856 EFM---KKVEEKRVDVNSAVAMGEVILAVCH-PDCI 4887



 Score = 44.7 bits (104), Expect = 0.003
 Identities = 43/238 (18%), Positives = 100/238 (42%), Gaps = 14/238 (5%)

Query: 6536 EMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR 6595
            E + A  ++       + QQ       + TWL   +++    K     + ++ ++ +++ 
Sbjct: 2716 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ--QAKNCPISAKLERLQSQLQE 2773

Query: 6596 LQEILKAFDTYKALVVSVNVSSKEFLQTESP--ESTELQSRLRQLSLLWEAAQGAVDSWR 6653
             +E  K+ + +      +    +  L +  P  E   LQ++L +L   WE         +
Sbjct: 2774 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQ 2833

Query: 6654 GGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT-DPKADPRALLECRRELMQLEKE 6712
              L+  + + Q +    ++L+ W+   K +  +  VT DP     +LL  +  L ++EK 
Sbjct: 2834 SRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK- 2892

Query: 6713 LVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGT 6770
               R+  +++L   ++ L+     ++    +EK  +      Q  + V+++L A  G+
Sbjct: 2893 ---RRSLLEILNSAADILINSSEADEDGIRDEKAGI-----NQNMDAVTEELQAKTGS 2942



 Score = 42.4 bits (98), Expect = 0.016
 Identities = 64/322 (19%), Positives = 125/322 (38%), Gaps = 49/322 (15%)

Query: 6537 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 6596
            M++ +   + L +K+ L+ LN     +T   K  + +LE+         +++   ++K L
Sbjct: 3124 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3178

Query: 6597 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLL-------- 6641
             +   A +  +AL       V  +N    +F   +  +   LQ +L+Q++ L        
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3238

Query: 6642 -------------------WEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6682
                               W      V      L+++L+ C  F    + LL WLA  + 
Sbjct: 3239 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE- 3297

Query: 6683 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 6742
                A+   P A+ + +    +E   L++ L +R+  VDMLQ     +       D  + 
Sbjct: 3298 -ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3356

Query: 6743 EEKVHVIEKKLKQL------REQVSQDLMAL-QGTQNPASPLPSFDEVDSGDQPPATSVP 6795
              ++  +E +  +L      R++  +D++ L +     A P+  F  V       +  V 
Sbjct: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416

Query: 6796 APRAK-QFRAVRTTEGEEETES 6816
               AK Q + +R    EE+ E+
Sbjct: 3417 TQTAKIQQQIIRHKALEEDIEN 3438



 Score = 38.1 bits (87), Expect = 0.30
 Identities = 45/255 (17%), Positives = 97/255 (38%), Gaps = 13/255 (5%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 6591
            WE +         K++  +Q   Q    + A+  WL  T   +++  M    +D+  ++ 
Sbjct: 4136 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV--IKLCTMPPVGTDLNTVKD 4193

Query: 6592 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAV 6649
            ++  ++E        +  +  +N   +  L+  + E+    ++  L +L  LWE     +
Sbjct: 4194 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4253

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
               +  L  +L+    F    + L+ WL   +             DP+ +     +   L
Sbjct: 4254 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI--SGDPKVIEVELAKHHVL 4311

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI----EKKLKQLREQVSQDLM 6765
            + +++  Q  V+ + +  N LL    G+D      ++  +    E  L++  E+  Q   
Sbjct: 4312 KNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4371

Query: 6766 ALQGTQNPASPLPSF 6780
             LQ  Q   S +  F
Sbjct: 4372 TLQQAQGFHSEIEDF 4386


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  206 bits (524), Expect = 6e-52
 Identities = 133/371 (35%), Positives = 193/371 (52%), Gaps = 44/371 (11%)

Query: 24  SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDK 83
           SL+ E++  QKK FT W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+K
Sbjct: 13  SLKDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREK 70

Query: 84  GSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQT 143
           G   F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I      
Sbjct: 71  GRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI------ 124

Query: 144 LSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNV 203
                      D+ V   S                  M+A++ LLLW+Q     Y+ +  
Sbjct: 125 ----------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRC 158

Query: 204 TDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPED 263
            +F SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PED
Sbjct: 159 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 218

Query: 264 VDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEND 323
           VDV  PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     + 
Sbjct: 219 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHT 277

Query: 324 TYFKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKI 382
             F++      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A ++
Sbjct: 278 AAFEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQL 333

Query: 383 KLNYALPPPLH 393
           K    +PP  H
Sbjct: 334 K----VPPGYH 340



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1087 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1146

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1147 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1206

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1207 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1261

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1305

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1360

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1361 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1417

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1473

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1474 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1648 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1681

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1682 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1720

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1781 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1827

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1828 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1945

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2005

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 2006 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2064

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2065 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2123 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2176 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2212

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2213 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2256

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2316

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2317 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2488

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2489 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2530

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2590

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2591 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2650

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2651 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2699



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 581  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 640

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 641  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 697

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 698  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 758  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 814

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 815  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 874

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 875  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 919

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 920  -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 968

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 969  DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1024

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1025 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1077

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1078 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1124

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1125 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1174

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1175 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1212

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1272

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1273 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1320

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1381 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1430 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1471

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1472 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1520

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1521 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1616

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1617 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1664

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1721

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1837

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1889

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 1890 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2008

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 2009 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2187 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2364 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2423 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2536

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2654

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2655 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2712

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2713 ASGFLLDPVRNRRLTVNEAVK 2733



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 913  AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 971

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 972  LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1026

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1027 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1086

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1087 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1145

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1146 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1205

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1206 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1257

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1258 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1317

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1376

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1492

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1493 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1543

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1544 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1655

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1656 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1710

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1711 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1767

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1768 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1823 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2055 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2109

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2110 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2155

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2212

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2213 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2267

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2268 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2319

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2320 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2368

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2546 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2604 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2658

Query: 3736 EL 3737
            EL
Sbjct: 2659 EL 2660



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 247  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 306

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 307  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 365

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 366  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 425

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 426  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 485

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 486  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 535

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 536  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 581

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 582  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 637

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 638  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 689

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 690  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 742

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 743  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 967

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 968  KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1027

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1028 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1076

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1196

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1197 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1317 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1369

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1370 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1407

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1583

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1584 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1637

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1689

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1690 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1747 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1805

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1806 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 1856

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 1857 RLEEQAA 1863



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 933  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 992

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 993  PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1052

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1053 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1112

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1113 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1158

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1216

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1217 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1267

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1328 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1496

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1497 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1549

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1550 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1662 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1706

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1707 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1767 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 1883 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 1942 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 1994

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 1995 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2047

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2048 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2105

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2106 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2164 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2213

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2271

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2272 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1170

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1171 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1230

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1231 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1290

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1291 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1350

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1404

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1405 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1464

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1465 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1504

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1505 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1555

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1556 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1611

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1723

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1779

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1822

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1875

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 1936 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2049

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2105

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2163

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2164 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2280 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2331

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2332 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2446

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2447 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2504 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2563

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2564 LLAEENQRLREQLQLLE 2580



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1320

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1321 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1354

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1355 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1410

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1411 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1519

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1520 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1570

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1571 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1628 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1682

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1683 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1721

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1722 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1770

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1771 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1805

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1806 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1858

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 1859 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1904

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 1905 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1954

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2015 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2038

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2039 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2069

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2127

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2128 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2166

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2167 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2220

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2221 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2275

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2331

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2392 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2495

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2496 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2546 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2606 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2656 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2709

Query: 6198 KQ 6199
             Q
Sbjct: 2710 AQ 2711



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1197 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1257 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1304

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1305 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1364

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1423

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1424 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1481

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1482 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1534

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1535 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1579

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1580 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1634

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1635 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1683

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1684 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1722

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1723 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1834

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1892

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 1893 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 1952 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2069

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2070 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2185 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2241

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2242 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2297

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2298 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2352

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2353 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2401

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2459

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2460 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2512

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2513 QRQQQQMEQE 2522



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1840 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1899

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 1900 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1951

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 1952 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2006

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2187 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2245

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2305

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2306 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2351

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2404

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2405 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2460

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2461 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2488



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 945  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 1002

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1058

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1059 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1118

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1119 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1177

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1178 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1237

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1238 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1294

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1295 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1344

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1404

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1405 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1453

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1512

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1571

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1085 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1144

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1145 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1204

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1205 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1254


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  204 bits (520), Expect = 2e-51
 Identities = 132/369 (35%), Positives = 191/369 (51%), Gaps = 44/369 (11%)

Query: 26  QAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGS 85
           Q E++  QKK FT W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+KG 
Sbjct: 37  QDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94

Query: 86  NTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLS 145
             F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I        
Sbjct: 95  MRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI-------- 146

Query: 146 CNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTD 205
                    D+ V   S                  M+A++ LLLW+Q     Y+ +   +
Sbjct: 147 --------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDN 182

Query: 206 FKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVD 265
           F SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PEDVD
Sbjct: 183 FTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVD 242

Query: 266 VVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTY 325
           V  PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     +   
Sbjct: 243 VPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAA 301

Query: 326 FKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKL 384
           F++      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A ++K 
Sbjct: 302 FEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK- 356

Query: 385 NYALPPPLH 393
              +PP  H
Sbjct: 357 ---VPPGYH 362



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1109 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1168

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1229 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1283

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1327

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1382

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1439

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1495

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1496 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1670 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1703

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1704 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1742

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1849

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1967

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2086

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2087 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2145 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2198 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2234

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2235 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2278

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2339 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2510

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2511 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2552

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2721



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 603  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 662

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 663  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 719

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 720  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 780  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 836

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 837  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 896

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 897  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 941

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 942  -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 990

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 991  DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1099

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1100 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1146

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1196

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1197 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1234

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1294

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1342

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1403 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1452 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1493

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1494 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1543 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1638

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1639 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1686

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1743

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1859

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1911

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2030

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2209 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2386 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2445 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2558

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2676

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2677 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2734

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2735 ASGFLLDPVRNRRLTVNEAVK 2755



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 935  AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 993

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 994  LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1048

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1108

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1109 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1228 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1279

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1398

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1514

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1515 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1565

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1677

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1678 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1732

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1733 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1789

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1790 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1845 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2077 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2131

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2132 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2177

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2235 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2289

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2341

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2342 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2390

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2568 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2680

Query: 3736 EL 3737
            EL
Sbjct: 2681 EL 2682



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 269  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 328

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 329  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 387

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 388  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 447

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 448  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 507

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 508  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 557

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 558  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 603

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 604  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 659

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 660  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 711

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 712  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 764

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 765  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 989

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 990  KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1049

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1050 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1339 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1392 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1429

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1605

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1606 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1659

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1711

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1712 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1827

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 1878

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 1879 RLEEQAA 1885



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 955  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 1015 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1074

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1180

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1238

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1239 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1350 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1518

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1519 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1571

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1572 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1684 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1789 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 1905 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 1964 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2016

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 2017 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2069

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2070 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2127

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2128 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2186 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2235

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2293

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2294 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1253 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1312

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1426

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1487 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1526

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1527 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1577

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1578 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1633

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1745

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1801

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1844

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1897

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 1958 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2071

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2127

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2185

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2186 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2302 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2353

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2354 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2469 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2586 LLAEENQRLREQLQLLE 2602



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1342

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1343 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1376

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1377 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1433 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1541

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1542 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1592

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1593 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1650 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1704

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1705 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1743

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1744 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1792

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1793 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1827

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1880

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1926

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 1927 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1976

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2037 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2060

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2061 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2091

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2149

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2150 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2188

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2189 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2242

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2243 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2297

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2353

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2414 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2517

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2518 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2628 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2731

Query: 6198 KQ 6199
             Q
Sbjct: 2732 AQ 2733



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1279 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1445

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1503

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1504 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1556

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1557 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1601

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1602 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1656

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1657 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1706 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1744

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1856

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1914

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 1915 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 1974 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2091

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2092 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2207 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2264 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2319

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2320 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2374

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2375 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2423

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2481

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2482 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2535 QRQQQQMEQE 2544



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1973

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 1974 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2028

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2209 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2373

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2426

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2482

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2483 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2510



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 967  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 1024

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1080

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1316

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1317 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1366

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1475

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1593

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1226

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1227 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1276


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  204 bits (520), Expect = 2e-51
 Identities = 135/388 (34%), Positives = 198/388 (51%), Gaps = 45/388 (11%)

Query: 8   PTEDEQGS-WGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHV 66
           P  DEQ      +++    + E++  QKK FT W+N  L +  +   ISDL+ D++ GH 
Sbjct: 4   PLPDEQDFIQAYEEVREKYKDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHN 61

Query: 67  LLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILG 126
           L+ LLEVLSG  LPR+KG   F    N++ AL +LR+R +KL+NI   DI DGNP + LG
Sbjct: 62  LISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLG 121

Query: 127 LIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKA 186
           LIWTIILHF I                 D+ V   S                  M+A++ 
Sbjct: 122 LIWTIILHFQI----------------SDIQVSGQSE----------------DMTAKEK 149

Query: 187 LLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAF 246
           LLLW+Q     Y+ +   +F SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF
Sbjct: 150 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 209

Query: 247 RIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWL 306
            +AE++L + RLL+PEDVDV  PDEKSI+TYV+         P   +  +   +  + W 
Sbjct: 210 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQ 268

Query: 307 TLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQ 365
             ++  L  L     +   F++      F  SF E +  +   L  K  +L   + D  +
Sbjct: 269 EYRELVLLLLQWMRHHTAAFEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNR 324

Query: 366 LREAWDGLDHQINAWKIKLNYALPPPLH 393
            +  +  L+  + A ++K    +PP  H
Sbjct: 325 SKGIYQSLEGAVQAGQLK----VPPGYH 348



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1095 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1154

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1155 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1214

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1215 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1269

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1313

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1368

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1369 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1425

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1426 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1481

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1482 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1595

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1655

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1656 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1689

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1690 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1728

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1789 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1835

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1836 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 1896 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1953

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2013

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 2014 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2072

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2073 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2131 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2184 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2220

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2221 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2264

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2324

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2325 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2496

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2497 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2538

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2598

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2599 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2658

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2659 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2707



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 589  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 648

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 649  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 705

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 706  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 765

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 766  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 822

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 823  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 882

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 883  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 927

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 928  -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 976

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 977  DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1032

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1033 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1085

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1086 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1132

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1133 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1182

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1183 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1220

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1280

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1281 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1328

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1389 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1438 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1479

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1480 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1528

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1529 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1624

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1625 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1672

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1729

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1845

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1897

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 1898 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1957

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 1958 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2016

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 2017 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2195 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2372 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2431 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2544

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2604

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2605 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2662

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2663 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2720

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2721 ASGFLLDPVRNRRLTVNEAVK 2741



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 921  AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 979

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 980  LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1034

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1035 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1094

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1095 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1213

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1214 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1265

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1266 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1325

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1384

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1500

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1501 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1551

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1552 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1663

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1664 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1718

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1719 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1775

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1776 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1831 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1942

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2063 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2117

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2118 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2163

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2220

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2221 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2275

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2276 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2327

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2328 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2376

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2554 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2612 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2666

Query: 3736 EL 3737
            EL
Sbjct: 2667 EL 2668



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 255  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 314

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 315  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 373

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 374  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 433

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 434  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 493

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 494  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 543

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 544  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 589

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 590  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 645

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 646  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 697

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 698  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 750

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 751  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 804  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 864  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 924  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 975

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 976  KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1035

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1036 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1084

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1204

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1205 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1264

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1325 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1377

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1378 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1415

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1591

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1592 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1645

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1697

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1698 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1755 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1813

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1814 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 1864

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 1865 RLEEQAA 1871



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 941  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1000

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 1001 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1060

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1061 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1120

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1121 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1166

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1224

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1225 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1275

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1336 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1504

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1505 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1557

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1558 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1670 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1714

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1715 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1775 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 1891 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 1950 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2002

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 2003 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2055

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2056 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2113

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2114 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2172 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2221

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2279

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2280 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2398

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1238

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1239 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1298

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1299 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1358

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1412

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1413 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1472

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1473 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1512

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1513 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1563

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1564 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1619

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1731

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1787

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1830

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1883

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 1944 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2057

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2113

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2171

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2172 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2288 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2339

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2340 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2454

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2455 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2512 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2571

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2572 LLAEENQRLREQLQLLE 2588



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1328

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1329 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1362

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1363 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1418

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1419 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1472 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1527

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1528 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1578

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1579 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1636 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1690

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1691 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1729

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1730 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1778

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1779 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1813

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1814 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1866

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 1867 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1912

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 1913 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1962

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2023 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2046

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2047 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2077

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2135

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2136 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2174

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2175 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2228

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2229 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2283

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2339

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2400 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2503

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2504 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2554 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2613

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2614 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2664 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2717

Query: 6198 KQ 6199
             Q
Sbjct: 2718 AQ 2719



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1205 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1264

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1265 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1312

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1313 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1372

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1431

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1489

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1490 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1542

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1543 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1587

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1588 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1642

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1643 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1691

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1692 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1730

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1731 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1842

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1900

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 1901 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 1960 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2077

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2078 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2193 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2249

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2250 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2305

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2306 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2360

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2361 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2409

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2467

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2468 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2520

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2521 QRQQQQMEQE 2530



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1848 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1907

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 1908 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1959

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 1960 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2014

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2195 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2313

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2314 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2359

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2412

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2413 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2468

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2469 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2496



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 953  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 1010

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1066

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1067 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1126

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1127 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1185

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1186 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1245

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1246 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1302

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1303 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1352

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1412

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1413 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1461

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1579

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1093 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1152

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1153 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1212

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1213 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1262


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  204 bits (519), Expect = 2e-51
 Identities = 132/372 (35%), Positives = 192/372 (51%), Gaps = 44/372 (11%)

Query: 23  ISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD 82
           I +  E++  QKK FT W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+
Sbjct: 61  IRIADERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE 118

Query: 83  KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
           KG   F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I     
Sbjct: 119 KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI----- 173

Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
                       D+ V   S                  M+A++ LLLW+Q     Y+ + 
Sbjct: 174 -----------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLR 206

Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
             +F SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PE
Sbjct: 207 CDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPE 266

Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEN 322
           DVDV  PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     +
Sbjct: 267 DVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHH 325

Query: 323 DTYFKKYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWK 381
              F++      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A +
Sbjct: 326 TAAFEERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQ 381

Query: 382 IKLNYALPPPLH 393
           +K    +PP  H
Sbjct: 382 LK----VPPGYH 389



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1136 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1195

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1196 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1255

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1256 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1310

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1311 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1354

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1409

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1410 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1466

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1522

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1523 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1697 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1730

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1731 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1769

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1829

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1830 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1876

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1877 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1994

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2054

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2113

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2114 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2172 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2225 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2261

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2262 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2305

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2365

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2366 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2537

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2538 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2579

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2639

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2640 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2699

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2700 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2748



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 630  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 689

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 690  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 746

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 747  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 806

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 807  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 863

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 864  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 923

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 924  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 968

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 969  -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1017

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 1018 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1073

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1074 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1126

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1127 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1173

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1174 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1223

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1224 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1261

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1262 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1321

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1322 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1369

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1430 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1479 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1520

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1521 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1569

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1570 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1665

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1666 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1713

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1770

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1886

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1938

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 1939 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1998

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 1999 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2057

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 2058 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2236 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2413 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2472 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2585

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2645

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2646 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2703

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2704 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2761

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2762 ASGFLLDPVRNRRLTVNEAVK 2782



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 962  AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1020

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 1021 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1075

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1076 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1135

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1136 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1194

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1195 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1254

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1255 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1306

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1307 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1366

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1425

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1541

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1542 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1592

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1593 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1704

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1705 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1759

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1760 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1816

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1817 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1871

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1872 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1923

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 1924 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1983

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2043

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 2044 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2104 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2158

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2159 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2204

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2261

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2262 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2316

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2317 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2368

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2369 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2417

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2595 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2653 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2707

Query: 3736 EL 3737
            EL
Sbjct: 2708 EL 2709



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 296  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 355

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 356  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 414

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 415  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 474

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 475  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 534

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 535  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 584

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 585  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 630

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 631  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 686

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 687  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 738

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 739  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 791

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 792  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 845  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 905  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 965  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 1016

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 1017 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1076

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1077 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1125

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1245

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1246 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1305

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1366 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1418

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1419 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1456

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1516

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1632

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1633 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1686

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1738

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1739 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1796 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1854

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 1905

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 1906 RLEEQAA 1912



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 982  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 1042 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1101

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1102 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1161

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1162 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1207

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1265

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1266 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1316

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1377 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1545

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1546 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1598

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1599 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1711 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1755

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1816 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1871

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1872 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 1932 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 1991 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2043

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 2044 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2096

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2097 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2154

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2155 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2213 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2262

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2320

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2321 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1219

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1220 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1279

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1280 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1339

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1340 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1399

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1453

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1454 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1513

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1514 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1553

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1554 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1604

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1605 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1660

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1772

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1828

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1871

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1872 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1924

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 1985 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2098

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2154

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2212

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2213 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2329 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2380

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2381 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2495

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2496 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2552

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2553 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2612

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2613 LLAEENQRLREQLQLLE 2629



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1369

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1370 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1403

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1404 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1459

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1460 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1568

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1569 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1619

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1620 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1677 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1731

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1732 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1770

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1771 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1819

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1820 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1854

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1907

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 1908 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1953

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 1954 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 2003

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 2004 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2064 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2087

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2088 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2118

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2176

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2177 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2215

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2216 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2269

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2270 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2324

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2380

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2441 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2544

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2545 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2595 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2655 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2705 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2758

Query: 6198 KQ 6199
             Q
Sbjct: 2759 AQ 2760



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1246 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1305

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1306 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1353

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1354 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1413

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1472

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1473 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1530

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1531 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1583

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1584 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1628

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1629 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1683

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1684 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1732

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1733 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1771

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1772 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1883

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1941

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 1942 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 2001 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2118

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2119 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2234 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2291 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2346

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2347 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2401

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2402 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2450

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2508

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2509 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2561

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2562 QRQQQQMEQE 2571



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1948

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 1949 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 2000

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 2001 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2055

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2236 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2294

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2354

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2355 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2400

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2453

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2454 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2509

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2510 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2537



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 994  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 1051

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1107

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1108 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1167

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1168 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1226

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1227 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1286

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1287 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1343

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1344 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1393

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1453

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1454 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1502

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1561

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1620

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1134 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1193

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1194 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1253

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1254 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1303


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  203 bits (517), Expect = 4e-51
 Identities = 661/3648 (18%), Positives = 1425/3648 (39%), Gaps = 484/3648 (13%)

Query: 2917 LKNLKIRTNRIQRFIQNTCNEVEHKIKFC------RQFHEKTSALQEEADSIQRNELLLN 2970
            L+N+++RT +IQ       N  E +   C      R+  + T+ + +E + +  N+++++
Sbjct: 1817 LRNIEMRTKQIQPL---ELNLAELQDLLCQAKVLERELKDLTTLVSQELECV--NQIIIS 1871

Query: 2971 Q------EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQV 3024
            Q      ++ K ++++  NL+  L+++                    W+   L       
Sbjct: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSD-----------------TWNSRLLH------ 1908

Query: 3025 FEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNA 3084
            F+   E+E K K L+   +  G+ Q L + +   +L        +L +  S+ E    + 
Sbjct: 1909 FQNAVEIE-KTKVLNQHTQLEGRLQDLRAWVGNKNL--------ILNSKGSNSEIDVDSL 1959

Query: 3085 QILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLEL 3144
             +  Q+ E  K    E   +L+    FD  F   E  Q  L+ ++N ++ ++L  +    
Sbjct: 1960 NLCLQQYEDLKQPMAERKAQLDA-LAFDIQFFISEHAQ-DLSPQQNRQMLRLLNEL---- 2013

Query: 3145 SPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQV--WAE 3202
                  +++ QD LE +   ++ ++  LQQ     L +K +Q +++ C    E +  W  
Sbjct: 2014 ------QRSFQDILEQTAAQVDALQGHLQQMEQEAL-VKTLQKQQNTCHQQLEDLCSWVG 2066

Query: 3203 MC-----------SIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
                         + + ++A++K + +      D++ +   F  +   +   ++     L
Sbjct: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126

Query: 3252 NDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQ 3311
            +     LT  +E + +A E   +L+      RV     EE++   L+++ E       + 
Sbjct: 2127 SP--RELTALREKLHQAKEQYEALQE---ETRVAQKELEEAVTSALQQETEKSKAAKELA 2181

Query: 3312 DLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRK 3366
            +  +K+  +     S   +  QL   L  +   + A  E      T+   Y+   +   K
Sbjct: 2182 ENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG--YMGVNQAPEK 2239

Query: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
            +++      ++ + +L Q  + + L+ + A   L+Q      NL  T EE   L+Q L  
Sbjct: 2240 LDKQCEMMKARHQELLSQQQNFI-LATQSAQAFLDQHG---HNL--TPEEQQMLQQKLGE 2293

Query: 3427 LRLRCTEN--DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAII 3484
            L+ + + +       LK V  L ++    L+  KE+E W E  ++E              
Sbjct: 2294 LKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE-------------- 2339

Query: 3485 LDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ---LLLTLLLQRIRSIQNV 3541
            L+N+          K  ++ E L  LL     + E+V   +     +T+  Q++  ++N 
Sbjct: 2340 LENMH---------KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 2390

Query: 3542 PESSGAVETVPAF--QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFF 3599
             +       +      ++    ER   L  K  +    +   + + H F     +L+ + 
Sbjct: 2391 FKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 2450

Query: 3600 QQTTTSFQNM----AFQDHPEKSEQF---EELQSILKKGKLTFENIMEKLRIKYSEMYTI 3652
            Q    + + +       D     EQ    ++LQ  L + ++  E + +  R    ++  I
Sbjct: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR----DIMEI 2506

Query: 3653 V--PAEIESQVEECRKALEDIDEKISNEVLKSSP--------SYAMRRKIEEINNGLHNV 3702
               PA     V+E   ++    + +S  + + S         S +++  +E +   +  V
Sbjct: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEV 2566

Query: 3703 EKMLQQKSKN------IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQ-DPGQAQEW 3755
            E+ L+ K  +      I++A     K+  ++    S L      V   +E  D   A   
Sbjct: 2567 EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2626

Query: 3756 MDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYD 3815
               L    Q+++Q+  + + + S L K   + E +  L    + ++EN S +LA+    D
Sbjct: 2627 QGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD 2686

Query: 3816 SLRTLSHHASTVQ---MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVT 3872
              + ++H    +Q   + +ED ++  + L  +  +L       +  +    +Q L    T
Sbjct: 2687 --QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFT 2744

Query: 3873 ALQQKIME---SLPQIQRMADD----VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE 3925
             LQ+ + E        Q   D+    V   +  +K  E  +   +T + +KE+     E+
Sbjct: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL-----EK 2799

Query: 3926 HLKHGEVILENIRPMKKTIAEIVSYQVELR------------------LPQTGMKPLPV- 3966
             ++H + +L++       + EI      L                   LP  G     V 
Sbjct: 2800 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2859

Query: 3967 -FQRTNQL------LQDIKL----LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNY 4015
             +     L      + D+ L    L  V  E+ E L+ ++ +  E  +E  ++ Q L + 
Sbjct: 2860 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919

Query: 4016 SAQF-SLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQE 4074
                 S++ MS     +  + Q E  +     L  N  K   + +  A +L  + +  QE
Sbjct: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN-SQE 2978

Query: 4075 QEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
             E  ++ +    +  E       A +R+L    S S+LA  +                AE
Sbjct: 2979 AENWKKIQEELNSRWERATEVTVARQRQLEE--SASHLACFQA---------------AE 3021

Query: 4135 PSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC 4194
               + W         ME++      G +  +    +  +     Q +  +     Q  E 
Sbjct: 3022 SQLRPWL--------MEKELMMGVLGPLSIDP--NMLNAQKQQVQFMLKEFEARRQQHE- 3070

Query: 4195 SLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
              + N+  +G        +L +S  Q  L+  + +   E T+ L++  +Q+ +       
Sbjct: 3071 --QLNEAAQGILTGPGDVSLSTSQVQKELQS-INQKWVELTDKLNSRSSQIDQ------- 3120

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
               A+   T   ++ Q L +++      L+ ++  ++   E  K Q L +    + + E 
Sbjct: 3121 ---AIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPEAVKQQ-LEETSEIRSDLEQ 3175

Query: 4315 LSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEP-EHQEALQPVNLSELESIVTER 4373
            L  ++K  +   +++ +++ E++ +D+    L+  + P +  E L    ++ L++ +   
Sbjct: 3176 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 3235

Query: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSP 4433
             QF +  D + +  L+ K  +Q    K    +AK    Q    +N+  Q+S  +  + S 
Sbjct: 3236 QQFQQMFD-ELRTWLDDKQSQQA---KNCPISAKLERLQSQLQENEEFQKS-LNQHSGSY 3290

Query: 4434 ENDVPDS---ILS-PQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            E  V +    +LS P G+     Q    EL +  +  L +    + S     +     Y 
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWE-ELSKKTADRQSRLKDCMQKAQKYQ 3349

Query: 4490 FRY----PTTEELKTYTTQL----EDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS 4541
            +      P  E+ K   ++L    + ++ E+S L+++  + E   +   + L E+  + +
Sbjct: 3350 WHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE---VEKRRSLLEILNSAA 3406

Query: 4542 QCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK----GDLLKAMTWPG 4597
              L +  E  E      + G  Q +   T  L+ K   L    ++     +  K +    
Sbjct: 3407 DILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV 3466

Query: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQ 4657
            E     LE FD L         +  C +K+L+      R+ Q  ++ L  Q+   +   Q
Sbjct: 3467 EGAKHQLEIFDAL--------GSQACSNKNLEK----LRAQQEVLQALEPQVDYLRNFTQ 3514

Query: 4658 QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLD 4717
              + +    S A QL         L  AE    +  +  +R++    +++   KLE +  
Sbjct: 3515 GLVEDAPDGSDASQL---------LHQAEVAQQEFLEVKQRVNSGCVMMEN--KLEGI-- 3561

Query: 4718 SMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIE 4777
               G    R  E+ S     +  D  L GM     IG++              +LQ+QIE
Sbjct: 3562 ---GQFHCRVREMFSQL---ADLDDELDGMGA---IGRDT------------DSLQSQIE 3600

Query: 4778 NHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
            + ++F  K+    L I+A  A+    L    E    + +   + LE  ++QCG   +   
Sbjct: 3601 DVRLFLNKIHVLKLDIEASEAECRHML---EEEGTLDLLGLKRELEALNKQCGKLTERGK 3657

Query: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETE----------ERLVERISFYQQI-KR 4886
             + E+ +     +E     L     + +  EE E          E + ++++ ++   K 
Sbjct: 3658 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKE 3717

Query: 4887 NIGGKHARLYQTLNEGKQLVASVS----CPELEGQIAKLEEQWLSLNKKIDHELHRLQAL 4942
             +     +L Q    G+ L+ S         LE  + ++  +W +LNKK+   + +LQ  
Sbjct: 3718 QVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777

Query: 4943 LKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKS 5002
            L H   +    + L  WL  ++  +   K  S     +   +++ I       + +D++ 
Sbjct: 3778 LLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQRLLDDRK 3833

Query: 5003 SLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPS 5061
            +    + + G ++    E  D   +   L   E +WT L+++    Q++L  + +     
Sbjct: 3834 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893

Query: 5062 RKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQS 5121
             +    +  +++  E + ++ + V + ++  +++  + +HK   +E D +    D V+Q+
Sbjct: 3894 HETAEPISDFLSVTEKKLANSEPVGTQTA--KIQQQIIRHKA--LEEDIENHATD-VHQA 3948

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE-SENKIQ 5180
            +    +    +   E+   +E +  +  ++  +     RK   L+Q L +     E++++
Sbjct: 3949 VKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008

Query: 5181 ILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA 5240
            +LN WL   E++L ++     V   ++ +L  Q  ++ LA+  + ++  K     +++G 
Sbjct: 4009 VLN-WLAEVEDKLSSV----FVKDFKQDVLHRQHADH-LALNEEIVNRKKNVDQAIKNGQ 4062

Query: 5241 VPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQL-------YDEVNMMT 5293
              L + T   +  + +K   + T+   +  +    L+  +   QL       Y+E+    
Sbjct: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 4122

Query: 5294 IRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVA- 5352
                  +  S     + E +    +  + L+ E        + + EV   L  L P  A 
Sbjct: 4123 REVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAR 4182

Query: 5353 EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLA 5412
            E +++   + ++++  V+  I  ++ +  + +Q  + Y  A     A + + + K   L 
Sbjct: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 4242

Query: 5413 NISMSGNNLAEILPPALQDIKELQHDVQKTK----EAFLQNSSVLDRLPQPAESSTHMLL 5468
             I +  +         LQ  K    D+ + K    E F   S +     +  ++      
Sbjct: 4243 PIRLEQDQTTA----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 4298

Query: 5469 PGPLHSLQRAAYLEKMLLVKANEFEFVLSQF----KDFGVRLESLKGLIMH------EEE 5518
               +   +  + L      +    + +++QF    ++    +E  + LI        + E
Sbjct: 4299 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358

Query: 5519 NLDRLHQQEKENPDSFLNH---VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQW 5575
             L +  ++ ++  +S   H   +  L    P ++ LN    ++   +   +  +NM  Q 
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV--EEKYQKAENMYAQI 4416

Query: 5576 ---IRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK 5632
               +R  A AL+     Q   + E             +KIE  L+     +L  L  + +
Sbjct: 4417 KEEVRQRALALDEAVS-QSTQITE-----------FHDKIEPMLE-----TLENLSSRLR 4459

Query: 5633 TYKMLEAEVS-INQTIADSY-VTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQGV 5688
               ++ AEV  I + I+D+   T  L+ L  +   ++ R E +   S+  D+   A    
Sbjct: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA---- 4515

Query: 5689 RQRKGDVDGLVRQWQD-----------FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQT 5737
            ++ +  +D +V  W+D           F   +E   +F  D + LL+ +K         T
Sbjct: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK--------DT 4567

Query: 5738 RSLIHELKNKEIH--FQRRRTTCALTLEA---------------GEKLLLTTDLKTKESV 5780
            + ++H+L++  I     +++   A T++                G  L+       K  V
Sbjct: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEV 4627

Query: 5781 GRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQ--VLKAQSEDPLP 5838
             + I ++ ++W+++     E +++ +  ++   Q +  ++ +   L   V+K  +   +P
Sbjct: 4628 RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MP 4684

Query: 5839 ELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD----LTRHVLVEDVMVLKEQIEHL 5894
             +  DL+  K+ + E+++      Q   E++ +       L +     D  +++E +  L
Sbjct: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4744

Query: 5895 HRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMI-- 5952
               WE+L  ++A R+ ++E  L     F    +EL +WL   E  +     IS +  +  
Sbjct: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4804

Query: 5953 -EKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVI 6010
             E  +   ++   L  +  ++ + + G++L+++S    A+ +  +L  +N  W+ +    
Sbjct: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864

Query: 6011 GSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQQD 6068
              R ++L+ T    Q     + +    L R+ES+LS  KP          + +   EQ D
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT-------GGLPETAREQLD 4917

Query: 6069 LQRDIEQHSAGVESVFN-ICD-----VLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
               ++       E  +N + D     +L  D     ++TE     Q+   L+++W  + +
Sbjct: 4918 THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE-----QSVALLEQKWHVVSS 4972

Query: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
               ER+ K+EE   L  +F +    F +WL  AE++    +   ++  +   +++  + F
Sbjct: 4973 KMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVF 5032

Query: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
              +++    Q+  +++   +L   ++      +K ++     RW+ + +R     R L  
Sbjct: 5033 ANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDD 5092

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNK 6299
               + ++F    + ++ WL + +  L +    S +D D    QL+    FQ+ +      
Sbjct: 5093 ARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPV 5151

Query: 6300 IDQLIVFGEQLIQKS-EPLDAVLIEDELEELHRYCQEVFGR-VSRFHR 6345
             D  I  G  L +K+  P D+  +++ L E+      V G+ V R H+
Sbjct: 5152 YDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199



 Score =  194 bits (493), Expect = 3e-48
 Identities = 338/1738 (19%), Positives = 664/1738 (38%), Gaps = 205/1738 (11%)

Query: 4740 QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ-----KLVADMLLIQ 4794
            QDAL + ++  +   +E +A+      + KV ++AQI+  K+  +     K   DML  +
Sbjct: 3785 QDAL-EPLLSWLADTEELIANQKPPSAEYKV-VKAQIQEQKLLQRLLDDRKATVDMLQAE 3842

Query: 4795 ----AYSAKI-----LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDE 4845
                A SA++     +   L++ E+ W E +++    +++       L+ +L   ++F E
Sbjct: 3843 GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ-------LEDILVLAKQFHE 3895

Query: 4846 NYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQL 4905
                +   L +    L +   V     ++ ++I  ++ ++ +I      ++Q +  G+ L
Sbjct: 3896 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955

Query: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS----YNRDSDQLTKWLE 4961
             +S++ P  +G +++  +   +   +I     R  ALL   LS    +  D  ++  WL 
Sbjct: 3956 -SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLA 4014

Query: 4962 SSQHTLNYWKEQSLNVSQ-DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
              +  L+     S+ V     D +     +    ++E+  +       I  G  LL  K+
Sbjct: 4015 EVEDKLS-----SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL--KQ 4067

Query: 5021 T---DTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEH 5077
            T   +   ++  L   + ++  +          L Q +      +    E+  W+  VE 
Sbjct: 4068 TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE 4127

Query: 5078 QTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYER 5137
            + +      SP+   Q+    Q+ KE + E+   + ++D VN+    +S   +E   +  
Sbjct: 4128 ELATSGG-QSPTG-EQIPQFQQRQKELKKEVMEHRLVLDTVNE----VSRALLELVPWRA 4181

Query: 5138 TEFAEHL-GEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL 5196
             E  + L  + N Q+  V   + +++  ++  ++   + E        W+   + +L  L
Sbjct: 4182 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241

Query: 5197 QKPESVISVQKLLLDCQDIENQLAI-KSKALDELKQSYLTLESGAVPLLEDTASRIDELF 5255
                       + L+      QL + K+ ++D ++                    +DELF
Sbjct: 4242 GP---------IRLEQDQTTAQLQVQKAFSIDIIRHK----------------DSMDELF 4276

Query: 5256 QKRSSVL-----TQVNQLKTSMQSVLQEWKIYDQLYDE-------VNMMTIRFWYCMEHS 5303
              RS +       Q   L+   +S++Q+++    L  E         ++  +FW   E  
Sbjct: 4277 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336

Query: 5304 KPVV--------------LSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCP 5349
             P +              +  E LR Q E ++ L++     +   +KL ++  +LK L P
Sbjct: 4337 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP 4396

Query: 5350 SVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQ 5409
               E++EEK Q     + Q+ + +  +       +      +  H +        E   +
Sbjct: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKI-------EPMLE 4449

Query: 5410 QLANISMSGNNLAEILPPALQDIKELQHD----------VQKTKEAFLQNSSVLDRLPQP 5459
             L N+S S   +  ++P  +  I+E   D          +Q + EA  +    L    Q 
Sbjct: 4450 TLENLS-SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508

Query: 5460 AESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL-ESLKGLIMHEEE 5518
            A+    +        L +  +  + +  +A E E       +   +    +  L+   ++
Sbjct: 4509 ADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566

Query: 5519 NLDRLHQQEKE--NPDSFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAV--------- 5565
              D +H  E    +P      V A      + + L+E    +++  +D+           
Sbjct: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626

Query: 5566 --KTLQNMNRQWIRATATALERCSEL----QGIGLNEKFLYCCEKWIQLLEKIEEALKVD 5619
              K++  MN  W     T  ER  +L    Q     +  L     W+     I+      
Sbjct: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPP 4685

Query: 5620 VANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE-FSKLT 5678
            V   L  + +Q    K  + EV   Q   +    Q   +L     E   + I E  ++L 
Sbjct: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELK 4745

Query: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSA---VKGQERFSLY 5735
              W+N  + +  R+  ++G +     F  ++E L  +LT T  LL A   + G  +    
Sbjct: 4746 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEV 4805

Query: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
            +     H LKN  +  Q    T     +AG +LL ++      S+  R+  +   W+ + 
Sbjct: 4806 ELAKH-HVLKNDVLAHQ---ATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861

Query: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ--SEDP---LPEL-HEDLHNEKE 5849
             +  E  +Q QST++       +I++    L  +++Q  +  P   LPE   E L    E
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921

Query: 5850 LIKELEQSLASWTQNLKELQTM---KADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
            L  +L+    ++ Q L + + M   + D       E  + L EQ      +W  +  ++ 
Sbjct: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKME 4975

Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK---------VLQTADISIEEMIEKLQK 5957
             RK ++E+ LN    F    +E   WL   E           +L T    IEE      K
Sbjct: 4976 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE-----HK 5030

Query: 5958 DCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
                E+N   +  ++L Q G+QL   S K     I + L  +  RW+ +      R + L
Sbjct: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090

Query: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
             +     +Q  +    L  WL   ES L   +     D  +I+ +L++ ++ Q+ +    
Sbjct: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN-DPDKIKLQLSKHKEFQKTL---- 5145

Query: 6078 AGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR-------RWRNICAMSMERRMK 6130
             G + V+   D  +    A   +T    + + ++ LD        +W  +C  S+ER+ K
Sbjct: 5146 GGKQPVY---DTTIRTGRALKEKT---LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199

Query: 6131 IEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERL 6190
            +EE      +F+D      DWL   E   A               +   + FQ+++ +R 
Sbjct: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 5259

Query: 6191 TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEF 6250
              ++++ +  R L   +R DT + +K  + E + RWD + +   +   RL     Q E F
Sbjct: 5260 GTVQVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF 5318

Query: 6251 EGTRESILVWLTEMDLQLTNVEHFSESDADD--KMRQL----NGFQQEITLNTNKIDQLI 6304
              T   +L WL+E +  L     F  +  DD   ++ L      F +++      ++  +
Sbjct: 5319 RDTVHMLLEWLSEAEQTL----RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAV 5374

Query: 6305 VFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASE 6362
              GE ++    P     I+  +  +    +EV     +  +RL +    L    E  E
Sbjct: 5375 AMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE 5432



 Score =  188 bits (478), Expect = 1e-46
 Identities = 631/3394 (18%), Positives = 1314/3394 (38%), Gaps = 522/3394 (15%)

Query: 3124 KLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIK 3183
            K N   N + ++  QN+       E DEK     L + L +L  I+ + +Q   + L + 
Sbjct: 1781 KGNGGVNPEPFRATQNVFTRQLCLEHDEK-----LVSYLSLLRNIEMRTKQIQPLELNLA 1835

Query: 3184 HIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENS-----SEASDVETKL-----REF 3233
             +Q+     +  + +       +K +T +  Q  E       S+  +V  +L     ++ 
Sbjct: 1836 ELQDLLCQAKVLERE-------LKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA 1888

Query: 3234 EDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPE--- 3290
            ++LQ  L++  D   + L   ++N    ++  T+ +   T LE  +   R  VGN     
Sbjct: 1889 KNLQKSLSSVSDTWNSRLLH-FQNAVEIEK--TKVLNQHTQLEGRLQDLRAWVGNKNLIL 1945

Query: 3291 -----------ESLEMPLRKQEELESTVAH-----------IQDLTEKLGMISSPEAKLQ 3328
                       +SL + L++ E+L+  +A            IQ    +     SP+   Q
Sbjct: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQ 2005

Query: 3329 -------LQYTLQELVSKNSAMKEAFKA--QETEAERYLENYKCYRKMEEDIYTNLSKME 3379
                   LQ + Q+++ + +A  +A +   Q+ E E  +   K  +K +   +  L  + 
Sbjct: 2006 MLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV---KTLQKQQNTCHQQLEDLC 2062

Query: 3380 TVLGQSMSSLP----LSYREALERLEQSKALVSNLIST-KEELMKLRQILRLLRLRCTEN 3434
            + +GQ+  +L      + ++ L  L+++++ + +L    +        +++ +     EN
Sbjct: 2063 SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 2122

Query: 3435 DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPE 3494
                  + ++AL EK    L  AKE     E L++E +   +E+E    +   LQ+E  +
Sbjct: 2123 QTKLSPRELTALREK----LHQAKEQY---EALQEETRVAQKELEEA--VTSALQQETEK 2173

Query: 3495 ISKTKEAATTEE-LSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPA 3553
                KE A  ++ +  LLD +   G +    QLL  L    +  +       GA++T   
Sbjct: 2174 SKAAKELAENKKKIDALLDWVTSVGSS--GGQLLTNL--PGMEQLSGASLEKGALDTTDG 2229

Query: 3554 FQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQD 3613
            +  +       N+  +K+ K  E+++     RH   +E+++ +  F   T S Q  AF D
Sbjct: 2230 YMGV-------NQAPEKLDKQCEMMKA----RH---QELLSQQQNFILATQSAQ--AFLD 2273

Query: 3614 HPEKSEQFEELQSILKK-GKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
                +   EE Q + +K G+L              E Y+   A+ E+++++ +   +++ 
Sbjct: 2274 QHGHNLTPEEQQMLQQKLGEL-------------KEQYSTSLAQSEAELKQVQTLQDELQ 2320

Query: 3673 EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHS 3732
            + + +     S      +++E ++ G  + E +     +    ++++     D   +  S
Sbjct: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTIS 2380

Query: 3733 KLNELDSEVQDIVEQDPGQAQEWM-DNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYS 3791
                LD E      ++P +    + D L    ++Y  +  +     S LN    +  ++ 
Sbjct: 2381 GQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQ 2440

Query: 3792 DLLKSTEAWIE----NTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL--LHSIF 3845
            +   S +AW++    N   LL++    D        A+T Q+  E +E +  +  L  + 
Sbjct: 2441 NSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVA 2500

Query: 3846 MDLEDLS---------IIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIE 3896
             D+ ++          +   TD +    Q LS  +      + +++ Q Q + + + ++ 
Sbjct: 2501 RDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560

Query: 3897 SEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRL 3956
              +  +E+ +   +   LS  +   +   ++K  + I      ++ T  E+V+  +E   
Sbjct: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEAT-REMVTRFMETAD 2619

Query: 3957 PQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
              T           +Q  + + L +   QE+   LK ++ Q   ++     L+Q + N S
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQ---QEKESSLKKLLPQAEMFEHLSGKLQQFMENKS 2676

Query: 4017 AQFSLEHMSPDQA-----DKLPQLQGEIERMEKQILSLNQRKEDLLVDLKAT--VLNLHQ 4069
               +  +  PDQ       ++ +L  E+E  ++ + +L    E L+ +L +    L+L Q
Sbjct: 2677 RMLASGNQ-PDQDITHFFQQIQELNLEMEDQQENLDTL----EHLVTELSSCGFALDLCQ 2731

Query: 4070 HLKQEQ----EGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVE--ESS 4123
            H  + Q    +  E  +      ++    +    E +   R    +L   E  +   E+S
Sbjct: 2732 HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS 2791

Query: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
            + +   +++ E           H K + +D AS   GT+V+E   K ++ +N + +I  P
Sbjct: 2792 MSAKELEKQIE-----------HLKSLLDDWASK--GTLVEEINCKGTSLENLIMEITAP 2838

Query: 4184 DSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKT 4243
            DS              Q + G+  P    ++ S +                    H CK 
Sbjct: 2839 DS--------------QGKTGSILPSVGSSVGSVNG------------------YHTCK- 2865

Query: 4244 QVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIE--HKVA-FLLETCKDQ 4300
             + E++  +   N+  E       +  VL ++    QA+L  +E  HK A  +L+  + +
Sbjct: 2866 DLTEIQCDMSDVNLKYE------KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919

Query: 4301 GLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKS--------SEP 4352
               +      +A +   K +TVK   E  +  L E   E   P I K          + P
Sbjct: 2920 ---EEVLKSMDAMSSPTKTETVKAQAESNKAFLAE--LEQNSPKIQKVKEALAGLLVTYP 2974

Query: 4353 EHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLE---------------LKP-MEQK 4396
              QEA    N  +++  +  R + + +    +Q+ LE               L+P + +K
Sbjct: 2975 NSQEA---ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEK 3031

Query: 4397 DFIKFI---------EFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQ 4447
            + +  +           NA+K   Q+        +E  A  Q     N+    IL+  G 
Sbjct: 3032 ELMMGVLGPLSIDPNMLNAQKQQVQF------MLKEFEARRQQHEQLNEAAQGILTGPGD 3085

Query: 4448 NGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLED 4507
                           + L   Q+ +   S N   +      N R    ++    +TQ ++
Sbjct: 3086 ---------------VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 3130

Query: 4508 LRQEAS----------NLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEML----EM 4553
            L Q+ S          ++Q+  +   EA     ++  E+   L Q    V+E      E+
Sbjct: 3131 LLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL 3190

Query: 4554 PRLYREDGSGQQV--HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ 4611
              L  E     ++    ET+AL L+ L    +D+   L  A+     +T    + FD L+
Sbjct: 3191 SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA----STQQFQQMFDELR 3246

Query: 4612 VCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQ 4671
              L+  Q      S+  K     N     +++RL  QL +     Q+SLN+ SG      
Sbjct: 3247 TWLDDKQ------SQQAK-----NCPISAKLERLQSQL-QENEEFQKSLNQHSG------ 3288

Query: 4672 LQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS 4731
                 +Y V +   ES +  +    E+      L  ++ +L++  + +      R + L 
Sbjct: 3289 -----SYEVIVAEGESLLLSVPPGEEK----RTLQNQLVELKNHWEELSKKTADRQSRLK 3339

Query: 4732 SPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV--AD 4789
                   +    ++ +V  ++  K K++   L+ T   V L++ +   K    ++     
Sbjct: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRS 3397

Query: 4790 MLLIQAYSAKILPSLLQNRETFWAEQVTEVK-----ILEEKSRQCGMKLQSLLQKWEEFD 4844
            +L I   +A IL +  +  E    ++   +      + EE   + G  L+ + Q+  EF 
Sbjct: 3398 LLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG-SLEEMTQRLREFQ 3456

Query: 4845 ENYASLEKDLE------ILISTLPSVSLVEETEERLVERISFYQQIKRNI---------- 4888
            E++ ++EK +E       +   L S +   +  E+L  +    Q ++  +          
Sbjct: 3457 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3516

Query: 4889 ------GGKHARL-------YQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE 4935
                  G   ++L        Q   E KQ V S  C  +E ++  +  Q+    +++  +
Sbjct: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNS-GCVMMENKLEGI-GQFHCRVREMFSQ 3574

Query: 4936 LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFS 4995
            L  L   L  + +  RD+D L   +E  +  LN      L    D++   +   +  E  
Sbjct: 3575 LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKL----DIEASEAECRHMLEEE 3630

Query: 4996 KEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
              +D    LK  + ++  Q   L E   A         +++  + + ++ D   KL  L 
Sbjct: 3631 GTLD-LLGLKRELEALNKQCGKLTERGKAR--------QEQLELTLGRVEDFYRKLKGLN 3681

Query: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
                 + +A  E + W+   E +  ++              + QK +   ++M  +Q  V
Sbjct: 3682 DATTAAEEA--EALQWVVGTEVEIINQQLADF--------KMFQKEQVDPLQMKLQQ--V 3729

Query: 5116 DFVNQSLLQLS--TCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESIT 5173
            + + Q L+Q +   CDV+   ++       + E+N +W+ ++  + ++I  L++ L    
Sbjct: 3730 NGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLNKKVAQRIAQLQEALLHCG 3782

Query: 5174 ESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSY 5233
            + ++ ++ L +WL   EE +   + P +   V K  +  Q +  +L    KA  ++ Q+ 
Sbjct: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQA- 3841

Query: 5234 LTLESGAVPLLEDTASR------IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYD 5287
               E G +    + A R      ++ L  + + +L++    +  ++ +L   K + +  +
Sbjct: 3842 ---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3898

Query: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
             ++         + +S+PV      ++ Q+   ++L+++ E+      +  ++   L  L
Sbjct: 3899 PISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL 3958

Query: 5348 -CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH--GEAAARLKQQ 5404
              P+   ++ EK  +   R+++    I D+  +  +LL   +A SNA   GE    +   
Sbjct: 3959 TSPAEQGVLSEKIDSLQARYSE----IQDRCCRKAALLD--QALSNARLFGEDEVEVLNW 4012

Query: 5405 EAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESST 5464
             A+ +   +     +   ++L     D   L  ++   K+   Q       L +      
Sbjct: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072

Query: 5465 HMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLES----LKGLIMHEEENL 5520
             +L+   L  + +  Y +  + V +++    L Q +    + +S    L G +   EE L
Sbjct: 4073 VLLIQEKLDGI-KTRYAD--ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL 4129

Query: 5521 -------------DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKL------PLS 5561
                          +  Q++KE     + H L L       + +NEVS  L         
Sbjct: 4130 ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL-------DTVNEVSRALLELVPWRAR 4182

Query: 5562 DVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVA 5621
            +   K + + N Q+   + T  +R  E+                IQ  ++ E+A   ++A
Sbjct: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAA-------------IQRSQQYEQAADAELA 4229

Query: 5622 NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRW 5681
                    ++K   +    +  +QT A   V ++  +      ++  E  +  S++    
Sbjct: 4230 WVAE---TKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTC 4286

Query: 5682 QNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAV-KGQERFS--LYQTR 5738
                + V Q K   + L++Q++  +      +  L     L++   +  E  S  + +TR
Sbjct: 4287 GEEQKTVLQEK--TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETR 4344

Query: 5739 SLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQL 5798
            +LI +L +  I  ++ R       +  E   L   +   +    ++ ++    K++ P+ 
Sbjct: 4345 ALIAQLPSPAIDHEQLRQ------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398

Query: 5799 AEMIKQ-FQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQS 5857
             EM+++ +Q     + Q ++++++    L    +QS   + E H+ +    E ++ L   
Sbjct: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ-ITEFHDKIEPMLETLENLSSR 4457

Query: 5858 LASWTQNLKELQTMKADLTRHVLVE------DVMVLKEQIEHLHRQWEDLCLRVA----- 5906
            L      +  L   + D  R  + +      ++  L+   E L R+ E+L  R       
Sbjct: 4458 L-----RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512

Query: 5907 IRKQEIEDRLNTWVVFNEKNK--------------ELCA--W--LVQMENKVLQTADI-- 5946
            +  +EI+D+L+  V F E  K              EL    W  +  +   +  T DI  
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572

Query: 5947 -----SIEEMIEKLQKDC----MEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLN 5997
                  I+  I K Q +      EE +   E    ++ +G  LI A  ++   E+   ++
Sbjct: 4573 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSID 4632

Query: 5998 KINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCD 6055
            ++N+ W++L      R++KL++      Q    +  +  WL     +L    PV  D+  
Sbjct: 4633 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL-- 4690

Query: 6056 DQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR 6115
               ++ +L E ++ + ++ Q    +E + +  +++L  +    +ET+ D I++    L  
Sbjct: 4691 -NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA---TDETDRDIIREPLTELKH 4746

Query: 6116 RWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
             W N+      R+ K+E       +F         WL   E                + E
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806

Query: 6176 LKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTA 6235
            L +    +  +      +E +NK    L   +  D AS L+  +   NQ W+++ ++   
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866

Query: 6236 VLRRLRHFTNQREEFEGTRESILVWLTEMDLQLT 6269
              ++L+    Q + F    E  L+ LT M+ QL+
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS 4900



 Score =  172 bits (435), Expect = 1e-41
 Identities = 667/3536 (18%), Positives = 1349/3536 (38%), Gaps = 517/3536 (14%)

Query: 2139 KLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-LQEKKAQLKIYKKFLKKAQDLTS 2197
            +L LE ++ L S   L L  IE++ KQ     L    LQ+   Q K+ ++ LK   DLT+
Sbjct: 1801 QLCLEHDEKLVSYLSL-LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELK---DLTT 1856

Query: 2198 LLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVC 2257
            L+ +        LEC      S+      + +   LL+ L+   +NL             
Sbjct: 1857 LVSQE-------LECVNQIIISQP-----QEVPAQLLKALEKDAKNLQ------------ 1892

Query: 2258 VTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALA--KS 2315
               L++  D ++   + F      Q AVE  ++K + L     L+ G L+ + A    K+
Sbjct: 1893 -KSLSSVSDTWNSRLLHF------QNAVE--IEKTKVLNQHTQLE-GRLQDLRAWVGNKN 1942

Query: 2316 VKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI-------LKSKRSTE 2368
            +  N+     +I  D +     + +DL+  +A  K +++     I        +     +
Sbjct: 1943 LILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQ 2002

Query: 2369 KKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMK 2428
             +    L    +++  D+ E T  +A V+ L+   +  +  A+   + KQ +   Q+   
Sbjct: 2003 NRQMLRLLNELQRSFQDILEQT--AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ--- 2057

Query: 2429 NTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGA 2488
                   + +L +   + +  L   Q    ++  + L+  ++ +K L Q +  N+  + A
Sbjct: 2058 -------LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDL-QDDIQNRATSFA 2109

Query: 2489 LVLHNI-GYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLK 2547
             V+ +I G+  ++   L    +T  + K      L   +E   A++   +    + E   
Sbjct: 2110 TVVKDIEGFMEENQTKLSPRELTALREK------LHQAKEQYEALQEETRVAQKELEEAV 2163

Query: 2548 VGPLDSVTYLDKIKKFIASIEKEKDSL----GNLKIKWENLSNHVTDMDK---KLLESQI 2600
               L   T   K  K +A  +K+ D+L     ++      L  ++  M++     LE   
Sbjct: 2164 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 2223

Query: 2601 KQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS--PEE 2658
                 G+  V Q  +K   Q  +       L+++ Q+  ++ Q  Q  L     +  PEE
Sbjct: 2224 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 2283

Query: 2659 RAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEP 2718
            +        L   L   K  +S    Q+E ++K++      + L+D +    +  +  E 
Sbjct: 2284 QQ------MLQQKLGELKEQYSTSLAQSEAELKQV------QTLQDELQKFLQDHKEFES 2331

Query: 2719 LHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQ---IRKCKVTHDGI 2775
                +E +++         ET+       G  +       +D++S    +R   ++   +
Sbjct: 2332 WLERSEKELENMHKGGSSPETLPSLLKRQGSFS-------EDVISHKGDLRFVTISGQKV 2384

Query: 2776 LARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEE 2835
            L  + S +      + K PS     G+ + + L+D   +Y  L  K T+    L   L +
Sbjct: 2385 LDMENSFK------EGKEPSEI---GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQ 2435

Query: 2836 RSNFFAIIRKFQLMVQESETLI-------------IPRVETAAT---EAELKHHHVTLEA 2879
               F       Q  +Q  E  +             + + + A T   + EL  H V +E 
Sbjct: 2436 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 2495

Query: 2880 SQK---ELQEIDSGIST---HLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQN 2933
             QK   ++ EI+   +    H+QE T+    L+ F+ L       +L  R++ +Q+ I  
Sbjct: 2496 LQKVARDIMEIEGEPAPDHRHVQETTDSI--LSHFQSLSY-----SLAERSSLLQKAIAQ 2548

Query: 2934 TCNEVEHKIKFCRQFHEKTSALQ-EEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIK 2992
            + +  E      +   E    L+ ++  S+    +      N  +K++I   K  L A +
Sbjct: 2549 SQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATR 2608

Query: 2993 CCILQVLKLKKVFDYIGLNWDFSQL----DQLQTQVFEKEKELEEKIKQLDTFEEEHGKY 3048
              + + ++         L    +++    +QL  Q  EKE  L++ + Q + FE   GK 
Sbjct: 2609 EMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKL 2668

Query: 3049 QALL---SKMRAIDLQ--------IKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKC- 3096
            Q  +   S+M A   Q         +++ E+ L+  D       L   +     E + C 
Sbjct: 2669 QQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV----TELSSCG 2724

Query: 3097 ----LCDEIIKKLNENKTFDDSFK-----EKEILQIKLNAEENDKLYKVLQNMVLE---- 3143
                LC    +  N  K F +  K     EK+    +   +E  KL +  Q  + E    
Sbjct: 2725 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2784

Query: 3144 LSPKE--LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQN---------EKDNC 3192
            + P E  +  K  + ++E    +L+   S+      IN +   ++N          +   
Sbjct: 2785 IPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKT 2844

Query: 3193 EAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLN 3252
             +    V + + S+       K   E   + SDV  K  +   +  +   S+    N + 
Sbjct: 2845 GSILPSVGSSVGSVNGYHTC-KDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRME 2903

Query: 3253 DAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQD 3312
            + ++      + +    E + S++A+  P + +    +   E       ELE     IQ 
Sbjct: 2904 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE--TVKAQAESNKAFLAELEQNSPKIQK 2961

Query: 3313 LTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKM 3367
            + E L  +     +S EA+   +   +EL S+     E   A++ + E    +  C++  
Sbjct: 2962 VKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020

Query: 3368 EEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLL 3427
            E  +   L + E ++G  +  L +       + +Q + ++    + +++  +L +  + +
Sbjct: 3021 ESQLRPWLMEKELMMG-VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGI 3079

Query: 3428 RLRCTENDGICL-----LKIVSALWEKWLSLLE--------------AAKEWEMWCEELK 3468
                T    + L      K + ++ +KW+ L +               + +++   ++L 
Sbjct: 3080 ---LTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLS 3136

Query: 3469 QEWKFVSEEIEREAIIL---DNLQEELPEIS-----------KTKEAAT-TEELSELLDC 3513
            ++ + V + +  ++ I    + ++++L E S           + KEA T  +ELS L+  
Sbjct: 3137 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG- 3195

Query: 3514 LCQYGENVEKQQL-LLTLLLQRIRSI--QNVPESSGAVETVPAFQEI-----TSMKERCN 3565
              QY ++  K++L  + L LQ +  +    +     A+ +   FQ++     T + ++ +
Sbjct: 3196 -EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQS 3254

Query: 3566 KLLQK--VQKNKELVQTEIQERHSFTKE------------------IIALKNFFQQTTTS 3605
            +  +   +    E +Q+++QE   F K                   ++++    ++ T  
Sbjct: 3255 QQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQ 3314

Query: 3606 FQNMAFQDH-PEKSEQFEELQSILK-------KGKLTFENI---MEKLRIKYSEM-YTIV 3653
             Q +  ++H  E S++  + QS LK       K +   E++   +E  + K SE+  T+ 
Sbjct: 3315 NQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLD 3374

Query: 3654 PAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNI 3713
            P ++ES +   +  L +++++ S   + +S +  +    E   +G+ + +  + Q    +
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434

Query: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRA 3773
               +E+Q K    L+    +L E     ++I ++  G   +         + +  +  +A
Sbjct: 3435 --TEELQAKT-GSLEEMTQRLREFQESFKNIEKKVEGAKHQ--------LEIFDALGSQA 3483

Query: 3774 ECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQM---- 3829
             C    L K   + E    L    +     T  L+ +  D      L H A   Q     
Sbjct: 3484 -CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3542

Query: 3830 --------------ALEDSEQKHNLLHSIFMDLEDL--------SIIFETDELTQSIQEL 3867
                           LE   Q H  +  +F  L DL        +I  +TD L   I+++
Sbjct: 3543 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3602

Query: 3868 S---NQVTALQQKIMESLPQIQRMAD-----DVVAIESEVKSMEKRVSKIKTILLSKEIF 3919
                N++  L+  I  S  + + M +     D++ ++ E++++ K+  K+     ++   
Sbjct: 3603 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKAR--- 3659

Query: 3920 DFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKL 3979
                +E L+     +E+     K + +  +   E    Q  +      +  NQ L D K+
Sbjct: 3660 ----QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG--TEVEIINQQLADFKM 3713

Query: 3980 LENVTQEQNELLKVVIKQTNEW----------DEEIENLKQILNNYSAQFSLEHMSPDQA 4029
             +   +EQ + L++ ++Q N            D +++ L+  +   +A+++   ++   A
Sbjct: 3714 FQ---KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNT--LNKKVA 3768

Query: 4030 DKLPQLQ------GEIERMEKQILSLNQRKEDLLVDLK--ATVLNLHQHLKQEQEGVER- 4080
             ++ QLQ      G+ +   + +LS     E+L+ + K  +    + +   QEQ+ ++R 
Sbjct: 3769 QRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL 3828

Query: 4081 --DRLPAV--TSEEGG-------VAERDASERKLNRRGS-----MSYLAAVEEEVEESSV 4124
              DR   V     EGG       +A+R+    +L    S     +S  AA ++++E+  V
Sbjct: 3829 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILV 3888

Query: 4125 KSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPD 4184
             +    E AEP     S   K  K    +   + +  I Q+             + L  D
Sbjct: 3889 LAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQII---------RHKALEED 3937

Query: 4185 SLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQ 4244
              N       +++  Q+    T P E         QG L  +++  +   +E+   C  +
Sbjct: 3938 IENHATDVHQAVKIGQSLSSLTSPAE---------QGVLSEKIDSLQARYSEIQDRCCRK 3988

Query: 4245 VAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGD 4304
             A L+  L  A +  E E       +VL          L E+E K++ +      Q +  
Sbjct: 3989 AALLDQALSNARLFGEDEV------EVLN--------WLAEVEDKLSSVFVKDFKQDVLH 4034

Query: 4305 NGATQHEA--EALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVN 4362
                 H A  E +  + K V   ++  Q +L++   E+      K          +   +
Sbjct: 4035 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTS 4094

Query: 4363 LSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ 4422
               L ++   R   ++ +   ++    L+ +E++      +    +  PQ+ Q   +  +
Sbjct: 4095 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 4154

Query: 4423 ESSASNQASSPENDVPDSILSP---QGQNG-DKWQYLHHELSSKIKLPLPQLVEPQVSTN 4478
            E           N+V  ++L     + + G DK     +E    +   + Q V+   +  
Sbjct: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214

Query: 4479 MGILPSVTMYNFRYPTTEELKTYTTQLEDLR----QEASNLQTQENMTEEAYINLDKKLF 4534
                      +       E K     L  +R    Q  + LQ Q+  + +   + D  + 
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD-SMD 4273

Query: 4535 ELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMT 4594
            ELF   S+   +  E  E   + +E        YE ++L   + Y  L  ++  +L    
Sbjct: 4274 ELFSHRSEIFGTCGE--EQKTVLQEKTESLIQQYEAISLLNSERYARL--ERAQVLVNQF 4329

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
            W         E ++ L   +E T+ A + +  S     +  R  Q E+++L   + + K 
Sbjct: 4330 W---------ETYEELSPWIEETR-ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKP 4379

Query: 4655 SLQ---------QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYAL 4705
             +          + LN   G+ V E+ QKA+    +++    + A   DE        + 
Sbjct: 4380 HIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEA------VSQ 4433

Query: 4706 LQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
              ++ +  D ++ M   L    + L  P +  ++ D + +       I   K A   L++
Sbjct: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE------CISDNKSATVELEK 4487

Query: 4766 TKSKVALQAQIENHKVFFQKLVA-DMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEE 4824
                  LQ   E  K   ++L+       +  +AK +   L     FW +       ++ 
Sbjct: 4488 ------LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED-------IKA 4534

Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASL---EKDLEILISTLPSVSLVEETEERLVERISFY 4881
            ++ +  +K   +L+  E+F  + A+L    KD + ++  L S  +     ++ VE     
Sbjct: 4535 RAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAA--- 4591

Query: 4882 QQIKRNIGGKHARLYQTLNEGKQLV---ASVSCPELEGQIAKLEEQWLSLNKKIDHELHR 4938
            + IK    G H  L      G  L+        PE+   I ++   W +LNK     L +
Sbjct: 4592 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651

Query: 4939 LQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEV 4998
            L+  ++  + Y      +  WL+++   L         V  DL+T++  +N   EF  EV
Sbjct: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP----VGTDLNTVKDQLNEMKEFKVEV 4707

Query: 4999 DEKSSLKTAVISIGNQLLH--LKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQM 5056
             ++      +   G  +L     ETD   +R  L + +  W  L  ++   Q KL    +
Sbjct: 4708 YQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4767

Query: 5057 EKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVD 5116
                 + A+ E++SW+ + E     +  +       +V+  L KH   + ++   Q  V+
Sbjct: 4768 ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--LAKHHVLKNDVLAHQATVE 4825

Query: 5117 FVNQS---LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESIT 5173
             VN++   LL+ S  D  S    R E       MN+ W  V      + Q L+  L+   
Sbjct: 4826 TVNKAGNELLESSAGDDASSLRSRLE------AMNQCWESVLQKTEEREQQLQSTLQQAQ 4879

Query: 5174 ESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDC-QDIENQLAIKSKALDEL--K 5230
               ++I+     L   E +L   +    +    +  LD   ++ +QL  K +  ++L  K
Sbjct: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939

Query: 5231 QSYLTL---ESG-------AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK 5280
               + L   +SG       +V LLE     +    ++R S L +   L T  Q+ LQE+ 
Sbjct: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF- 4998

Query: 5281 IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV 5340
                    +N +T+     +  + P  L L T+  Q+E  +   +E  +      +L + 
Sbjct: 4999 --------INWLTLA-EQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 5049

Query: 5341 IGKLKGLCPSV-AEIIEEKCQNTHKRWTQVNQ-------AIADQLQKAQSLLQLWK 5388
              +LK L       +I+    +   RW +V Q       ++ D  ++A+   + WK
Sbjct: 5050 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWK 5105



 Score =  122 bits (305), Expect = 2e-26
 Identities = 555/3237 (17%), Positives = 1235/3237 (38%), Gaps = 420/3237 (12%)

Query: 396  EAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHL 455
            +AW+Q  E  +++ LS +      V  +QE++   K L +    H               
Sbjct: 2447 QAWMQACEANVEKLLSDTVASDPGV--LQEQLATTKQLQEELAEHQ-------------- 2490

Query: 456  PLVPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV 515
              VP  KL+++ R I  I  +        H +   V    D + S     ++ Y   E  
Sbjct: 2491 --VPVEKLQKVARDIMEIEGEP----APDHRH---VQETTDSILSHFQ--SLSYSLAERS 2539

Query: 516  ELLLEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCM------ 569
             LL +      + +     L++  Q  GE+ +NL G      KQ   + S V        
Sbjct: 2540 SLLQK---AIAQSQSVQESLESLLQSIGEVEQNLEG------KQVSSLSSGVIQEALATN 2590

Query: 570  --YRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHAT 627
               +++I   KS+L+        ++E      A   + K  E+ +   +   Q   + ++
Sbjct: 2591 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2650

Query: 628  LNEAGNFLVEVSNDVVGSSISKELRR-LNKRWRKLVSKTQLEMNLP---LMIKKQDQPTF 683
            L +       +    +   +S +L++ +  + R L S  Q + ++      I++ +    
Sbjct: 2651 LKKL------LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEME 2704

Query: 684  DNSGNILSKEEKATVEFSTDMSVELPENYN--QNIKAG----EKHEKENEEFTGQLKVAK 737
            D   N+ + E   T   S   +++L ++ +  QN++      +K  KE E+     +   
Sbjct: 2705 DQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQL 2764

Query: 738  D-VEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQ 796
            D   KL+   + W  E +  +   +   S +E  K +    S+ D+  ++   + +++ +
Sbjct: 2765 DEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCK 2824

Query: 797  NISSQESFQHVLTTGLQAKIQEAKEKVQINV--VKLIAALKNLTDVSPDL-DIRLKMEES 853
              S +     +     Q K       V  +V  V      K+LT++  D+ D+ LK E+ 
Sbjct: 2825 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKL 2884

Query: 854  QKELESYMMRAQQLLGQRESPGELISKHKEA-LIISNTKSLAKYLKAVEELKNNVTEDIK 912
               L       Q +L + E        HKEA  ++   +S  + LK+++ + +    +  
Sbjct: 2885 GGVLHERQESLQAILNRMEEV------HKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2938

Query: 913  MSLEEKSRDVCAKWESLHHELSLYVQQLK---IDIEKGKLSDNILKLEKQINKE-----K 964
             +  E ++   A+ E    ++    + L    +     + ++N  K+++++N       +
Sbjct: 2939 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2998

Query: 965  KLIRRGRTKGLIKEHEACFSEEGC-----LYQLNHHMEVLRELCEELPSQKSQ-QEVKRL 1018
              + R R       H ACF          L +    M VL  L  +     +Q Q+V+ +
Sbjct: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 3058

Query: 1019 LKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
            LK++E + ++        H  L   A G     G ++ S ++           + + Q  
Sbjct: 3059 LKEFEARRQQ--------HEQLNEAAQGILTGPGDVSLSTSQ----------VQKELQSI 3100

Query: 1079 TEKAMEPTMKFSLAS------VLRPLQEESIMEKDYSASINSLLERYDTYRDI-LEHHLQ 1131
             +K +E T K +  S      +++  Q + +++ D S  + ++ +R      I  +    
Sbjct: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ-DLSEKVRAVGQRLSVQSAISTQPEAV 3159

Query: 1132 NNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPF 1191
              +   TS+  S+ ++    L  ++ + Q + +E      E + +  +L+  +  +  P 
Sbjct: 3160 KQQLEETSEIRSDLEQ----LDHEVKEAQTLCDELSVLIGE-QYLKDELKKRLETVALPL 3214

Query: 1192 VIKERDTLKERERELQMTLNT--RMESLETALRLVLPVEKASLLL-CGSDLPLHKMAIQG 1248
               E D   +R   LQ  L +  + + +   LR  L  +++     C     L ++  Q 
Sbjct: 3215 QGLE-DLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ- 3272

Query: 1249 FHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFD-LHAMQNIILKYKTQ 1307
                      Q     Q S+ +       +   G  +L  + P +    +QN +++ K  
Sbjct: 3273 ---------LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNH 3323

Query: 1308 FEGMNHR-----------VQRS-------EDTLKALEDFLASLRTAKLSAEPVTDLSASD 1349
            +E ++ +           +Q++       ED +  +ED  A +   +++ +PV   S+  
Sbjct: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383

Query: 1350 TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK 1409
               A  N   V+ +   + ++   A  L    +  +   +D + G + + + + +    K
Sbjct: 3384 RSKAMLNE--VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 3441

Query: 1410 LSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
                   G  EE T+  +  +   FKN E  K ++  + Q+           + K+ +K 
Sbjct: 3442 T------GSLEEMTQRLREFQES-FKNIE--KKVEGAKHQLEIFDALGSQACSNKNLEK- 3491

Query: 1470 LIRLDKVLDEYEEEKRHLQEMANSLPH-FKDGREKT-VNQQCQNTVVLWENTKALVTECL 1527
            L    +VL   E +  +L+     L     DG + + +  Q +     +   K  V    
Sbjct: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551

Query: 1528 EQCGRVLELLKQYQ-NFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE 1586
                  LE + Q+    + + + L   ++ +  + A     ++L+ +I ++ +   + + 
Sbjct: 3552 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3611

Query: 1587 HLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALA 1646
                ++     C+++   L +  T +    ++E   +  +   + E+ +   E L   L 
Sbjct: 3612 LKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668

Query: 1647 LWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL----QVHEQKTSEFSRRVAE 1702
              +  +     +++ T  A +   L  +   + E + ++L       +++      ++ +
Sbjct: 3669 RVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728

Query: 1703 I----QFLLQSSEIPLELQVMESSI---------LNKMEHVQKCLTGESNCHALSGSTAE 1749
            +    Q L+QS+    ++Q +E  +         LNK    +     E+  H       +
Sbjct: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC-----GK 3783

Query: 1750 LREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQ-----KHSMILLENQI 1804
             ++ L+   + +  TE L+    P  +     K +  +Q++LQ+     K ++ +L+ + 
Sbjct: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843

Query: 1805 GCL------------TPELSELKKQYESVSDLFNTKKSVLQDHF--SKLLNDQCKNFNDW 1850
            G +            T +L  L+ ++  +      ++  L+D    +K  ++  +  +D+
Sbjct: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903

Query: 1851 FSNIKVNLKECFE-SSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAH 1909
             S  +  L       ++T K  +Q ++  +    +E   + + Q   + + +      A 
Sbjct: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3963

Query: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
               L   +   +    +++  C  +A  L+ +L       +D   +  WL   E+K   +
Sbjct: 3964 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 4023

Query: 1970 EEPGEKTELF----CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTL 2025
                 K ++        LA   E       ++ ++K      ++    E   + ++   +
Sbjct: 4024 FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083

Query: 2026 LRQLSEIE-EEDKLLPTEDQS------FNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
              + ++I     K L T +Q+      F     ++  W++E++E L    +S G+ P  E
Sbjct: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGE 4140

Query: 2079 RI----QKIKEIILLKPEGDARIETIMKQAESSEAPL----------VQKTLTDISNQWD 2124
            +I    Q+ KE+     E    ++T+    E S A L          + K ++D + Q+ 
Sbjct: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVN---EVSRALLELVPWRAREGLDKLVSDANEQYK 4197

Query: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKI 2184
                     +   +  +   ++Y Q+ +     + E K+K  A   ++    +  AQL++
Sbjct: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 4257

Query: 2185 YKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD-SVQN 2243
             K F          + EL S  + +       +  EE    ++   ESL+QQ +  S+ N
Sbjct: 4258 QKAFSIDIIRHKDSMDELFSHRSEIFG-----TCGEEQKTVLQEKTESLIQQYEAISLLN 4312

Query: 2244 LDGHVREHDSYQVCVTDLNTTLDNFS------KEFVSFSDKP-VDQIAVEEKLQKLQELE 2296
             + + R   + QV V     T +  S      +  ++    P +D   + ++ +++++L 
Sbjct: 4313 SERYARLERA-QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 4371

Query: 2297 NRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEME-- 2354
              ++     + K+L +   +K+     G+ + +        K +  EN  A  K+E+   
Sbjct: 4372 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE--------KYQKAENMYAQIKEEVRQR 4423

Query: 2355 --CCLNSILKSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
                  ++ +S + TE   K   P  E  +  +S ++      A V+K+ E    NK + 
Sbjct: 4424 ALALDEAVSQSTQITEFHDKIE-PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSAT 4482

Query: 2411 VEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK-- 2468
            VE+   +     + E++K   +E  +   Q    +L      ++L+++   +  ++A+  
Sbjct: 4483 VELEKLQP----SFEALKRRGEEL-IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4537

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            +  IK L+  E   K       L       Q + + L++             +++   E 
Sbjct: 4538 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-------PGIDPSIIKQQVEA 4590

Query: 2529 LAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHV 2588
               ++     L  + E +++   D +    + +K    + K  D + N    WENL+   
Sbjct: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNNA---WENLNKTW 4645

Query: 2589 TDMDKKLLESQIKQLEHG------WEQVEQQIQKKYSQQVVEYDEFTTL--MNKVQDTEI 2640
             +  +KL ++    +++       ++ ++  + K  +   V  D  T    +N++++ ++
Sbjct: 4646 KERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV 4705

Query: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
             + QQQ  ++                               L  Q EL +K+   E ++ 
Sbjct: 4706 EVYQQQIEMEK------------------------------LNHQGELMLKKATDETDRD 4735

Query: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKC-----DIRNKMKETILWAKNLLGELNPSIP 2755
             + + +  LK  WE L       +++++         ++ ++E + W  +    L+   P
Sbjct: 4736 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4795

Query: 2756 LLPDDILSQIRKCK--VTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRN 2813
            +  D  + ++   K  V  + +LA Q +VE++ +   + + S    + S L + LE +  
Sbjct: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855

Query: 2814 QYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAA---TEAEL 2870
             ++ ++ K+ +R QQL+  L++   F + I  F L +   E+ +     T     T  E 
Sbjct: 4856 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQ 4915

Query: 2871 KHHHVTLEASQKELQEI----------------DSGISTHLQELTNIYEELNVFERLFLE 2914
               H+ L +  K  +E                 DSG  +  ++   + E+        +E
Sbjct: 4916 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975

Query: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSA----LQEEADSIQRNELLLN 2970
            ++   L+   N    F QN+  E  + +    Q     S     L      I+ +++  N
Sbjct: 4976 ERKSKLEEALNLATEF-QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034

Query: 2971 QEVNKGVKEEIYNLKDRLTAIKCCILQ--VLKLKKVFDYIGLNWDFSQLDQLQTQVFEKE 3028
             EVN   +++I  L      +K    +  V+ +K +   +   W+     ++  +  E+ 
Sbjct: 5035 -EVNAH-RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE-----KVVQRSIERG 5087

Query: 3029 KELEEKIKQLDTFEEEHGKYQALLSKMRA--------------IDLQIKKMTEVVLKAPD 3074
            + L++  K+   F E   K    L    +              I LQ+ K  E       
Sbjct: 5088 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 5147

Query: 3075 SSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLY 3134
              P     +  I + R  K K L  E  +KL+    F    ++K       + E   KL 
Sbjct: 5148 KQPV---YDTTIRTGRALKEKTLLPEDSQKLDN---FLGEVRDKWDTVCGKSVERQHKLE 5201

Query: 3135 KVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEA 3194
            + L           L      D L+  +  L +++ QL +   ++ ++  + N  D  + 
Sbjct: 5202 EAL-----------LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250

Query: 3195 FQEQVWAEMCSIKAVTAIEKQREENS-SEASDVETKLREFE---DLQMQLNTSIDLRTNV 3250
            FQ+++     +++ +    ++  ENS  + + V+ +L+E     D   +L+ S   R   
Sbjct: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR--- 5307

Query: 3251 LNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP-------LRKQEEL 3303
            L  A +    +++ V   +E ++  E   + +R  + +  E+L+         ++K EE 
Sbjct: 5308 LEQALKQAEVFRDTVHMLLEWLSEAEQ-TLRFRGALPDDTEALQSLIDTHKEFMKKVEEK 5366

Query: 3304 ESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC 3363
               V     + E +  +  P+    +++ +  + ++   +    K  +   E  L     
Sbjct: 5367 RVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 5426

Query: 3364 YRKMEEDIYTNLSKMETVLGQ-SMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
              ++ E++   +   ET L Q     +P       + +++ KAL++   +  EE+ +
Sbjct: 5427 NAELLEELLAWIQWAETTLIQRDQEPIP-------QNIDRVKALIAEHQTFMEEMTR 5476



 Score =  118 bits (296), Expect = 2e-25
 Identities = 582/3197 (18%), Positives = 1209/3197 (37%), Gaps = 490/3197 (15%)

Query: 975  LIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKS--QQEVKRLLKDYEQKIERLLKC 1032
            ++K+ E  F EE         +  LRE   +   Q    Q+E +   K+ E+ +   L+ 
Sbjct: 2111 VVKDIEG-FMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQ 2169

Query: 1033 ASEIHMTLQPTAGGTSKNEGT---ITTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKF 1089
             +E     +  A    K +     +T+  + GG   +  P  +  +  S EK    T   
Sbjct: 2170 ETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229

Query: 1090 SLASVLRP--LQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDR 1147
             +     P  L ++  M K     + S  + +       +  L  +   +T +       
Sbjct: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE------- 2282

Query: 1148 SSSCLQAKLTDLQVIKN----ETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERE 1203
                LQ KL +L+   +    +++A  K+ + +  +L+  + D K+         L+  E
Sbjct: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE-----FESWLERSE 2337

Query: 1204 RELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRN 1263
            +EL+  ++    S ET   L+      S  +      L  + I G  ++D +  ++  + 
Sbjct: 2338 KELE-NMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 2396

Query: 1264 IQDSIAKQIEICNRLEEPGNFVLKELHPFD-----LHAMQNIILKYKTQFEGMNHRVQRS 1318
                            E GN V  +L         LH+    +  +     G  H+ Q S
Sbjct: 2397 PS--------------EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 2442

Query: 1319 EDTLKALEDFLASLRTAKLSAEPV-TDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHL 1377
             D+L+A       ++  + + E + +D  ASD  V QE   T K  + E+   +   + L
Sbjct: 2443 ADSLQAW------MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 2496

Query: 1378 DKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNN 1437
             K  + + M  +     D    +   D+       +H   +     E + LL+  I ++ 
Sbjct: 2497 QKVARDI-MEIEGEPAPDHRHVQETTDSIL-----SHFQSLSYSLAERSSLLQKAIAQSQ 2550

Query: 1438 ELLKNIQDVQSQISKI--GLKDPTVPAVKHR--KKSLIRLDKVLDEYEEEKRHLQEMANS 1493
             + ++++ +   I ++   L+   V ++     +++L    K+  +   +K  L+     
Sbjct: 2551 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2610

Query: 1494 LPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQK 1553
            +  F +  + T       T  + +   A V++  EQ      L  Q Q  +S L  L+ +
Sbjct: 2611 VTRFMETADST-------TAAVLQGKLAEVSQRFEQ------LCLQQQEKESSLKKLLPQ 2657

Query: 1554 EESVISLQASYMG-KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
             E    L        EN  + +A      ++     + + ++N   ++ Q          
Sbjct: 2658 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ---------- 2707

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                           LD  E       + G AL L      ++N+  ++TE  LQK    
Sbjct: 2708 -------------ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTE--LQKTVKE 2752

Query: 1673 QLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQK 1732
            +  E+D    +E+L    +    F + + E +  +  +E  +  + +E  I    EH++ 
Sbjct: 2753 R--EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQI----EHLKS 2806

Query: 1733 CLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSL-EIFTKLEEIQQQI- 1790
             L   +       S   L E+++   T +   E+L+  ++  DS  +  + L  +   + 
Sbjct: 2807 LLDDWA-------SKGTLVEEINCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVG 2856

Query: 1791 -LQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL--LNDQCKNF 1847
             +   H+   L  +I C   ++S++  +YE +  + + ++  LQ   +++  ++ +  + 
Sbjct: 2857 SVNGYHTCKDL-TEIQC---DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912

Query: 1848 NDWFSNIKVNLKECFESSETKKSVEQKLQKLSD--FLT-LEGRNSKIKQVDSVLKHVKKH 1904
              W  + +  LK     S   K+   K Q  S+  FL  LE  + KI++V   L  +   
Sbjct: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972

Query: 1905 LPKAHVKELISWLVGQEFEL----EKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLT 1960
             P +   E  +W   QE EL    E+   +  AR ++LE+S   L   Q     LR WL 
Sbjct: 2973 YPNSQEAE--NWKKIQE-ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 3029

Query: 1961 NQEEKWKGMEEP-----------GEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEE 2009
             ++E   G+  P            ++ +   +    +R+Q E   QLN + +    T   
Sbjct: 3030 -EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE---QLNEAAQGI-LTGPG 3084

Query: 2010 EIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQ---------SFNDLAHDVIHWIKEI 2060
            ++ +  + +    Q++ ++   +E  DKL     Q          + +L  D+   ++ +
Sbjct: 3085 DVSLSTSQVQKELQSINQKW--VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 3142

Query: 2061 KESLMVLN---------------SSEGKMPLEERIQKIKEIILLKPEGDARI-ETIMKQA 2104
             + L V +               +SE +  LE+   ++KE   L  E    I E  +K  
Sbjct: 3143 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202

Query: 2105 ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKK 2164
                   ++K L  ++        LA+  ++  +  L   +++ Q  ++LR  L + + +
Sbjct: 3203 -------LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 3255

Query: 2165 QEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECT---KNPSFSEE 2221
            Q     +   L+  ++QL+  ++F K     +   + + ++G  LL      +     + 
Sbjct: 3256 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 3315

Query: 2222 PWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVD 2281
              +E+K+  E L ++  D    L   +++   YQ  V DL   +++  K  +S     +D
Sbjct: 3316 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED-CKAKMSELRVTLD 3374

Query: 2282 QIAVEEKLQK----LQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD------ 2331
             + +E  L +    L E+E R SL +     IL  A  +  N+S   +  I+D+      
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLE-----ILNSAADILINSSEADEDGIRDEKAGINQ 3429

Query: 2332 ----------------------IKSLQCKQKDLENRLASAKQEME--------CCLNSIL 2361
                                  ++  Q   K++E ++  AK ++E         C N  L
Sbjct: 3430 NMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL 3489

Query: 2362 KSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQL 2419
            +  R+ ++  +   P  +  +  T  + E   + +   +L    E+ +   +E+   KQ 
Sbjct: 3490 EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV---KQR 3546

Query: 2420 SLNAQESMKNT-----EDERKVNELQNQPLELDTML------------RNEQLEEIEKLY 2462
              +    M+N      +   +V E+ +Q  +LD  L               Q+E++    
Sbjct: 3547 VNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFL 3606

Query: 2463 TQLEAKKAAIKPLEQTECLNK-TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521
             ++   K  I+  E  EC +   E G L L  +    + L+     L    K ++ Q  +
Sbjct: 3607 NKIHVLKLDIEASE-AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLEL 3665

Query: 2522 ----LRDFQEYLAAVESSMKALLTDKESLK--VGPLDSVTYLDKIKKFIASIEK-EKDSL 2574
                + DF   L  +  +  A   + E+L+  VG     T ++ I + +A  +  +K+ +
Sbjct: 3666 TLGRVEDFYRKLKGLNDATTA-AEEAEALQWVVG-----TEVEIINQQLADFKMFQKEQV 3719

Query: 2575 GNLKIKWENLSNHVTDMDKKLLES-----QIKQLEHGWEQVEQQ---IQKKYSQQVVEYD 2626
              L++K +     V  + + L++S      ++ LEH  E++  +   + KK +Q++ +  
Sbjct: 3720 DPLQMKLQ----QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3775

Query: 2627 EFTTLMNKVQDT---EISLQQQQQHLQLRLKSPEE-----RAGNQSMIALTTDLQATKHG 2678
            E      K QD     +S     + L    K P       +A  Q    L   L   K  
Sbjct: 3776 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3835

Query: 2679 FSVLKGQ-AELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMK 2737
              +L+ +   +       ++EK  +   + +L+ +W  L          + K   R K  
Sbjct: 3836 VDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTEL----------LSKAAARQKQL 3883

Query: 2738 ETIL-WAKNLLGELNPSIPLL---------PDDILSQIRKCKVTHDGILARQQSVESLAE 2787
            E IL  AK       P    L          + + +Q  K +       A ++ +E+ A 
Sbjct: 3884 EDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHAT 3943

Query: 2788 EVKDKV------PSLTT-YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFF 2840
            +V   V       SLT+  E   L+  ++ L+ +Y  +  +  +++  L+  L     F 
Sbjct: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 4003

Query: 2841 AIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTN 2900
                +    + E E  +         +  L   H    A  +E+      +   ++    
Sbjct: 4004 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 4063

Query: 2901 IYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEAD 2960
            + ++    E L ++++L  +K R       I  T ++    ++  RQ   K  +  EE  
Sbjct: 4064 LLKQTTGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLATKFQSTYEELT 4119

Query: 2961 SIQR--NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIG--------- 3009
               R   E L          E+I   + R   +K    +V++ + V D +          
Sbjct: 4120 GWLREVEEELATSGGQSPTGEQIPQFQQRQKELK---KEVMEHRLVLDTVNEVSRALLEL 4176

Query: 3010 LNWDFSQ-LDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEV 3068
            + W   + LD+L +   E+ K + + I Q    +E     Q      +A D ++  + E 
Sbjct: 4177 VPWRAREGLDKLVSDANEQYKLVSDTIGQ--RVDEIDAAIQRSQQYEQAADAELAWVAET 4234

Query: 3069 VLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAE 3128
              K     P   RL     + +++  K    +II+      + D+ F  +  +      E
Sbjct: 4235 KRKLMALGP--IRLEQDQTTAQLQVQKAFSIDIIR---HKDSMDELFSHRSEIFGTCGEE 4289

Query: 3129 ENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQ-----------------IKSQ 3171
            +   L +  ++++ +     L       +LE +  ++NQ                 + +Q
Sbjct: 4290 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ 4349

Query: 3172 LQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQ-REENSSEASDVETKL 3230
            L  P    ++ + ++ +++     +E +      I  +  I  Q +E N  E   VE K 
Sbjct: 4350 LPSPA---IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY 4406

Query: 3231 REFEDLQMQLNTSIDLRTNVLNDAYE---NLTRYKEAVTRAVESITSLEA-----IIIPY 3282
            ++ E++  Q+   +  R   L++A      +T + + +   +E++ +L +      +IP 
Sbjct: 4407 QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA 4466

Query: 3283 RVD------VGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQEL 3336
             VD        N   ++E+     E+L+ +   ++   E+L   S    K      +Q+ 
Sbjct: 4467 EVDKIRECISDNKSATVEL-----EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521

Query: 3337 VSKNSAMKEAFKAQETEAE-RYLENYKCYRKMEEDIYTNLSKMETV--LGQSMSSLPLSY 3393
            + +     E  KA+  E E ++L+  +   K   D+   L+ ++    +   + S  +  
Sbjct: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581

Query: 3394 REALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSL 3453
                +++E ++ +        EEL  +R +   L   C E +   + K +  +   W +L
Sbjct: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4641

Query: 3454 LEAAKEWEMWCEELKQEWKFVSEEIEREAIILDN-----------------LQEELPEIS 3496
             +  KE     E+  Q      + ++     LDN                 ++++L E+ 
Sbjct: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMK 4701

Query: 3497 KTK-----EAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPES------- 3544
            + K     +    E+L+   + + +   +   + ++   L +     +N+ E        
Sbjct: 4702 EFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHK 4761

Query: 3545 -SGAVETVPAFQ----EITSMKERCNKLL---QKVQKNKELVQTEIQERHSFTKEIIALK 3596
              GA+  +  FQ    E+ S      +LL   + +  + ++++ E+ + H    +++A  
Sbjct: 4762 LEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA-- 4819

Query: 3597 NFFQQTTTSFQNMAFQDHPEKS--EQFEELQSILKKGKLTFENIMEKLRIKYSEMY-TIV 3653
                Q T    N A  +  E S  +    L+S L+     +E++++K   +  ++  T+ 
Sbjct: 4820 ---HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQ 4876

Query: 3654 PAE-IESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
             A+   S++E+    L  ++ ++S            R +++       ++E   Q K+K 
Sbjct: 4877 QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT------HMELYSQLKAK- 4929

Query: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
                +E   ++ D+              +  +   D G   +   ++ +  Q++  VS +
Sbjct: 4930 ----EETYNQLLDK------------GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4973

Query: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALE 3832
             E R S+L +A     E+ + L+    W+      L N A   SL       +TV   +E
Sbjct: 4974 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSL-----ILNTVLSQIE 5027

Query: 3833 DSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDV 3892
            +        H +F +     +    D++ + + +  NQ+  L QK             DV
Sbjct: 5028 E--------HKVFAN----EVNAHRDQIIE-LDQTGNQLKFLSQK------------QDV 5062

Query: 3893 VAIESEVKSMEKRVSKI 3909
            V I++ + S++ R  K+
Sbjct: 5063 VLIKNLLVSVQSRWEKV 5079



 Score =  115 bits (288), Expect = 2e-24
 Identities = 496/2763 (17%), Positives = 1051/2763 (38%), Gaps = 318/2763 (11%)

Query: 1475 KVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVL 1534
            ++L   E++ ++LQ+  +S+    + R        QN V + E TK L  +  +  GR+ 
Sbjct: 1879 QLLKALEKDAKNLQKSLSSVSDTWNSRLL----HFQNAVEI-EKTKVL-NQHTQLEGRLQ 1932

Query: 1535 ELLKQYQNFKSILTTLIQKEE-SVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDK 1593
            +L     N   IL +     E  V SL       E+LK+ +AE +              +
Sbjct: 1933 DLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA-------------Q 1979

Query: 1594 INQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLF- 1652
            ++ +  ++QF++++      P   ++   +      +NE    + + L +  A  D L  
Sbjct: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRL------LNELQRSFQDILEQTAAQVDALQG 2033

Query: 1653 NLKNVIDEWTEKALQKME--LHQLTEEDRE---RLKEELQVHEQKTSEFSRRVAEIQFLL 1707
            +L+ +  E   K LQK +   HQ  E+      + +  L  H+ +T++        Q L 
Sbjct: 2034 HLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQ--------QDLS 2085

Query: 1708 QSSEIPLELQVMESSILNKMEH---VQKCLTG--ESNCHALSG-STAELREDLDQAKTQI 1761
               +   +L+ ++  I N+      V K + G  E N   LS      LRE L QAK Q 
Sbjct: 2086 ALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY 2145

Query: 1762 GMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESV 1821
               +   +            +LEE     LQQ       E +      EL+E KK+ +++
Sbjct: 2146 EALQEETRVAQK--------ELEEAVTSALQQ-------ETEKSKAAKELAENKKKIDAL 2190

Query: 1822 SDLFNTKKSVLQDHFSKL----------LNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
             D   +  S      + L          L     +  D +  +    ++  +  E  K+ 
Sbjct: 2191 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 2250

Query: 1872 EQKL--QKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKEL----ISWLVGQEFELE 1925
             Q+L  Q+ +  L  +   + + Q    L   ++ + +  + EL     + L   E EL+
Sbjct: 2251 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK 2310

Query: 1926 KMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALAR 1985
            ++++        L+D LQ+ L+   DH+    WL   E++ + M + G   E     L R
Sbjct: 2311 QVQT--------LQDELQKFLQ---DHKEFESWLERSEKELENMHKGGSSPETLPSLLKR 2359

Query: 1986 KREQFE-----------------SVAQLNNSLKEYGFTEE-----EEIIMEATCLMDRYQ 2023
            +    E                  V  + NS KE     E     ++ + +AT   +RY 
Sbjct: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDAT---ERYT 2416

Query: 2024 TLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESL-MVLNSSEGKMP--LEERI 2080
             L  + + +     +L  +   F + A  +  W++  + ++  +L+ +    P  L+E++
Sbjct: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476

Query: 2081 QKIKEIILLKPEGDARIETIMKQA------ESSEAP---LVQKTLTDISNQWDNTLHLAS 2131
               K++     E    +E + K A      E   AP    VQ+T   I + + +  +  +
Sbjct: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG--FALQHG-LQEKKAQLKIYKKF 2188
               S  +K + + +   +S E L   + E+++  E     +L  G +QE  A     K+ 
Sbjct: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596

Query: 2189 LKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHV 2248
            + + +      +E+ ++     + T   +  +    E+    E L  Q Q+   +L   +
Sbjct: 2597 IARQKSSLEATREMVTRFMETADST-TAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2655

Query: 2249 REHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKK 2308
             + + ++     L   ++N S+   S +    D   +    Q++QEL   +  Q   L  
Sbjct: 2656 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQD---ITHFFQQIQELNLEMEDQQENLDT 2712

Query: 2309 ILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECC---LNSILKSKR 2365
            +  L   +     ++     +D +++L+    +L+  +   +++   C   L+   K  R
Sbjct: 2713 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2772

Query: 2366 STEKKGKFTLPGREKQATS-DVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSL-NA 2423
            + +K  K T        TS   +E  ++   ++ L +DW  +K + VE    K  SL N 
Sbjct: 2773 TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW-ASKGTLVEEINCKGTSLENL 2831

Query: 2424 QESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNK 2483
               +   + + K   +               +  +   +T    K       + ++   K
Sbjct: 2832 IMEITAPDSQGKTGSILPSV--------GSSVGSVNGYHT---CKDLTEIQCDMSDVNLK 2880

Query: 2484 TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDK 2543
             E    VLH      + L  +L  +  + K   S    L   +E L ++++      T  
Sbjct: 2881 YEKLGGVLHE---RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP--TKT 2935

Query: 2544 ESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKI---------KWENLSNHVTDMDKK 2594
            E++K     +  +L ++++    I+K K++L  L +          W+ +   +    ++
Sbjct: 2936 ETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWER 2995

Query: 2595 LLESQI---KQLEHGWEQVE--QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHL 2649
              E  +   +QLE     +   Q  + +    ++E +    ++  +      L  Q+Q +
Sbjct: 2996 ATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQV 3055

Query: 2650 QLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNL 2709
            Q  LK  E R             Q  +    +L G  ++ +     +KE       + ++
Sbjct: 3056 QFMLKEFEARRQQHE--------QLNEAAQGILTGPGDVSLSTSQVQKE-------LQSI 3100

Query: 2710 KKQWETLEPLHLEAENQIKKCDIRNKMKETILW-------AKNLLGELNPSIPLLPDDIL 2762
             ++W  L        +QI +  +++   + +L        A      +  +I   P+ + 
Sbjct: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 3160

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSL--TTYEGSDLNNTLEDLRNQYQMLVL 2820
             Q+ +       +      V+  A+ + D++  L    Y   +L   LE +    Q L  
Sbjct: 3161 QQLEETSEIRSDLEQLDHEVKE-AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLED 3219

Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS 2880
             +  R  +L+  L       A  ++FQ M  E  T +  +    A    +      L++ 
Sbjct: 3220 LAADRINRLQAAL-------ASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 3272

Query: 2881 QKELQEIDSGISTHLQELTNIYEE-----LNV---FERLFLEDQLKNLK----------- 2921
             +E +E    ++ H      I  E     L+V    E+  L++QL  LK           
Sbjct: 3273 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTA 3332

Query: 2922 IRTNRIQRFIQNTCN---EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVK 2978
             R +R++  +Q        VE  + +      K S L+   D +Q    LL    +K + 
Sbjct: 3333 DRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLR---SKAML 3389

Query: 2979 EEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFE----KEKELEEK 3034
             E+   +  L  +      +L      D  G+  + + ++Q    V E    K   LEE 
Sbjct: 3390 NEVEKRRSLLEILNSA-ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEM 3448

Query: 3035 IKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKA 3094
             ++L  F+E    ++ +  K+     Q++    +  +A  +    +    Q + Q +E  
Sbjct: 3449 TQRLREFQE---SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQ 3505

Query: 3095 KCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQN--MVLELSPKELDEK 3152
                    + L E+   D S   + + Q ++  +E  ++ + + +  +++E   + + + 
Sbjct: 3506 VDYLRNFTQGLVEDAP-DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564

Query: 3153 NCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAI 3212
            +C  ++      L  +  +L     I  +   +Q++ ++   F  ++      I+A  A 
Sbjct: 3565 HC--RVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE 3622

Query: 3213 EKQREENSSEASDVETKLREFEDLQMQL----------NTSIDLRTNVLNDAYENLTRYK 3262
             +   E       +  K RE E L  Q              ++L    + D Y  L    
Sbjct: 3623 CRHMLEEEGTLDLLGLK-RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681

Query: 3263 EAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQ--EELESTVAHIQDLTEKLG 3318
            +A T A E+    EA+  ++   V++ N + +     +K+  + L+  +  +  L + L 
Sbjct: 3682 DATTAAEEA----EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLI 3737

Query: 3319 MISSPEAKLQ-LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSK 3377
              +  +  +Q L++ ++E+ ++ + + +    +  + +  L +   ++   E + + L+ 
Sbjct: 3738 QSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD 3797

Query: 3378 METVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGI 3437
             E ++  +       Y+    ++++ K L   L   K  +  L+     +       D  
Sbjct: 3798 TEELIA-NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE 3856

Query: 3438 CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISK 3497
             +   + +L  +W  LL  A   +   E++    K   E  E    I D L     +++ 
Sbjct: 3857 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP---ISDFLSVTEKKLAN 3913

Query: 3498 TKEAAT-TEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQE 3556
            ++   T T ++ + +       E++E      T + Q ++  Q++   +   E     ++
Sbjct: 3914 SEPVGTQTAKIQQQIIRHKALEEDIENH---ATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3970

Query: 3557 ITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSF---------Q 3607
            I S++ R +++  +  +   L+   +     F ++ + + N+  +              Q
Sbjct: 3971 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 4030

Query: 3608 NMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKA 3667
            ++  + H +     EE+ +  K      +N    L+    E   +    I+ +++  +  
Sbjct: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLL----IQEKLDGIKTR 4086

Query: 3668 LEDIDEKISNEVLKSSPSYAMRRKI----EEINNGLHNVEKML------QQKSKNIEKAQ 3717
              DI    S  +     +  +  K     EE+   L  VE+ L          + I + Q
Sbjct: 4087 YADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ 4146

Query: 3718 EIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF-QQYQQVSQRAECR 3776
            + QK++  E+      L+ ++   + ++E  P +A+E +D L+    +QY+ VS     R
Sbjct: 4147 QRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQR 4206

Query: 3777 TSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQ 3836
              +++ A  + ++Y     +  AW+  T   L           L    +T Q+ ++ +  
Sbjct: 4207 VDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI----RLEQDQTTAQLQVQKAFS 4262

Query: 3837 KHNLLHSIFMD--LEDLSIIFET---------DELTQSIQELSNQVTALQQKIMESLPQI 3885
               + H   MD      S IF T          E T+S+ +    ++ L  +    L + 
Sbjct: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 4322

Query: 3886 QRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIA 3945
            Q + +       E+    +    +   L S  I      +  +    + E+I   K  I 
Sbjct: 4323 QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 4382

Query: 3946 EIVSYQVELR--LPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQT--NEW 4001
            +++    +L+   P+ G      +Q+   +   IK  E V Q    L + V + T   E+
Sbjct: 4383 KLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK--EEVRQRALALDEAVSQSTQITEF 4440

Query: 4002 DEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-------EIERMEKQILSLNQRKE 4054
             ++IE + + L N S++  +  + P + DK+ +          E+E+++    +L +R E
Sbjct: 4441 HDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGE 4500

Query: 4055 DLL 4057
            +L+
Sbjct: 4501 ELI 4503



 Score =  108 bits (269), Expect = 2e-22
 Identities = 158/821 (19%), Positives = 326/821 (39%), Gaps = 59/821 (7%)

Query: 4667 SVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYA--------LLQEVYKLEDVLDS 4718
            +V +QL +   + VE+   +  + KL  +GE L L  A        + + + +L+ + ++
Sbjct: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE-LMLKKATDETDRDIIREPLTELKHLWEN 4750

Query: 4719 MWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIEN 4778
            +   +  R  +L    +   Q    L+ ++  +   +E L          KV ++ ++  
Sbjct: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV-IEVELAK 4809

Query: 4779 HKVFFQKLVADMLLIQAYS--------------AKILPSLLQNRETFWAEQVTEVKILEE 4824
            H V    ++A    ++  +              A  L S L+     W   + +    EE
Sbjct: 4810 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT---EE 4866

Query: 4825 KSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQI 4884
            + +Q    LQ       E ++    L +    L ++ P+  L E   E+L   +  Y Q+
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926

Query: 4885 KRNIGGKHARLYQTLNEGKQLVA----SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
            K     K     Q L++G+ ++     S S  + E  +A LE++W  ++ K++    +L+
Sbjct: 4927 K----AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982

Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
              L     +     +   WL  ++ +LN     SL     L+T+ S I     F+ EV+ 
Sbjct: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL----ILNTVLSQIEEHKVFANEVNA 5038

Query: 5001 KSSLKTAVISIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
                   +   GNQL  L ++ D   ++  L   + +W  ++ +  +    L   +    
Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098

Query: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF-- 5117
               +A  ++I W+ + E     E  +   +   ++K  L KHKEF+  +  KQ + D   
Sbjct: 5099 QFHEAWKKLIDWLEDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156

Query: 5118 -VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
               ++L + +    +S++ +       LGE+  +W  V G    +   LE+ L    +  
Sbjct: 5157 RTGRALKEKTLLPEDSQKLD-----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 5211

Query: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDI-ENQLAIKSKALDELKQSYLT 5235
            + +Q L +WL   E +L   Q     + +   L+D   + + +L  ++  +  LK+S   
Sbjct: 5212 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRE 5271

Query: 5236 LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIR 5295
            L   +     D  + +    Q+ S+    V +L  S QS L++     +++ +   M + 
Sbjct: 5272 LIENS----RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327

Query: 5296 FWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEII 5355
            +   +  ++  +     L    E LQSL D  +      E+ +  +     +   +  + 
Sbjct: 5328 W---LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 5384

Query: 5356 EEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS 5415
               C  T K W  + +A  +++       Q     + +   A A L ++   + Q A  +
Sbjct: 5385 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 5444

Query: 5416 MSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
            +   +  E +P  +  +K L  + Q   E   +    +DR+
Sbjct: 5445 LIQRD-QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484



 Score =  105 bits (263), Expect = 1e-21
 Identities = 377/2035 (18%), Positives = 792/2035 (38%), Gaps = 291/2035 (14%)

Query: 4496 EELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLS--SVEEMLEM 4553
            + L     Q EDL+Q  +  + Q          LD   F++   +S+     S ++  +M
Sbjct: 1957 DSLNLCLQQYEDLKQPMAERKAQ----------LDALAFDIQFFISEHAQDLSPQQNRQM 2006

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ-V 4612
             RL  E     Q   E  A ++  L   L   + + L       +NT     C   L+ +
Sbjct: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT-----CHQQLEDL 2061

Query: 4613 CL---EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG---- 4665
            C    +  +A A  + ++ +  L   +  Q+++K L   +    TS    + +I G    
Sbjct: 2062 CSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEE 2121

Query: 4666 ----------QSVAEQLQKADAYTVELENAESRVAK----------LRDEGERLHLPYAL 4705
                       ++ E+L +A      L+  E+RVA+          L+ E E+      L
Sbjct: 2122 NQTKLSPRELTALREKLHQAKEQYEALQE-ETRVAQKELEEAVTSALQQETEKSKAAKEL 2180

Query: 4706 LQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA----HG 4761
             +   K++ +LD  W         ++S   +  Q    L GM +L     EK A     G
Sbjct: 2181 AENKKKIDALLD--W---------VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229

Query: 4762 HLKQTKSKVALQAQIENHKVFFQKLVADM--LLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
            ++   ++   L  Q E  K   Q+L++     ++   SA+       +  T   +Q+ + 
Sbjct: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQ 2289

Query: 4820 KILEEKSRQCGM----------------KLQSLLQKWEEFDENYASLEKDLEIL------ 4857
            K+ E K +                    +LQ  LQ  +EF+      EK+LE +      
Sbjct: 2290 KLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSS 2349

Query: 4858 ISTLPSVSLVEETEERLVERISFYQQIKRNI---GGKHARLYQTLNEGKQLVASVSCPEL 4914
              TLPS+    + +    E +  ++   R +   G K   +  +  EGK+   S     +
Sbjct: 2350 PETLPSLL---KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE--PSEIGNLV 2404

Query: 4915 EGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQS 4974
            + ++    E++ +L+ K       L  LL     +   +D L  W+++ +   N  K  S
Sbjct: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE--ANVEKLLS 2462

Query: 4975 LNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLL-----------HLKETDT 5023
              V+ D   ++  +    +  +E+ E       +  +   ++           H++ET  
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522

Query: 5024 A------TLRASLAQFEQKWTMLITQLPDIQEKLHQL-----QMEKLPSRKAITEMISWM 5072
            +      +L  SLA+        I Q   +QE L  L     ++E+    K ++ + S +
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582

Query: 5073 NNVEHQTS---DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCD 5129
                  T+    +D     SS    + ++ +  E            D    ++LQ    +
Sbjct: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFME----------TADSTTAAVLQGKLAE 2632

Query: 5130 VESK-------RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLES-------ITES 5175
            V  +       + E+    + L      +  + G L + +++  ++L S       IT  
Sbjct: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692

Query: 5176 ENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELKQSYL 5234
              +IQ LN  +E Q+E L TL+   + +S     LD CQ  +         +  L++ + 
Sbjct: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR--------VQNLRKDFT 2744

Query: 5235 TLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTI 5294
             L+       +D +S  ++L + R  V T    LK +  S+            E +M   
Sbjct: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP---------TETSMSAK 2795

Query: 5295 RFWYCMEHSKPVV-------LSLETLRCQVENLQSLQDE--AESSEGSWEKLQEVIGKLK 5345
                 +EH K ++         +E + C+  +L++L  E  A  S+G    +   +G   
Sbjct: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855

Query: 5346 G------LCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAA 5399
            G       C  + E I+    + + ++ ++   + ++ +  Q++L         H EA +
Sbjct: 2856 GSVNGYHTCKDLTE-IQCDMSDVNLKYEKLGGVLHERQESLQAIL---NRMEEVHKEANS 2911

Query: 5400 RLKQQEAKFQQLANI-SMSGNNLAEILPPA-------LQDIKELQHDVQKTKEAFLQNSS 5451
             L+  E+K + L ++ +MS     E +          L ++++    +QK KEA    + 
Sbjct: 2912 VLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL---AG 2968

Query: 5452 VLDRLPQPAESSTHMLLPGPLHS-LQRAAYL----EKMLLVKANE---FEFVLSQFKDFG 5503
            +L   P   E+     +   L+S  +RA  +    ++ L   A+    F+   SQ + + 
Sbjct: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 3028

Query: 5504 VRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-------- 5555
            +  E + G++     + + L+ Q K+     L    A   Q    E LNE +        
Sbjct: 3029 MEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQH---EQLNEAAQGILTGPG 3084

Query: 5556 -LKLPLSDVAVKTLQNMNRQWIRATATALERCSEL-QGIGLNEKFLYCCEKWIQLLEKIE 5613
             + L  S V  K LQ++N++W+  T     R S++ Q I  + ++    +   + +  + 
Sbjct: 3085 DVSLSTSQVQ-KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143

Query: 5614 EALKVDVA-NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI- 5671
            + L V  A ++ PE ++QQ       +E+  +    D  V ++  L D   +    +++ 
Sbjct: 3144 QRLSVQSAISTQPEAVKQQLEE---TSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200

Query: 5672 TEFSKLTDRWQNAVQGVRQRKGD----VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
             E  K  +     +QG+     D    +   +   Q F    + L  +L D      A  
Sbjct: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL-DDKQSQQAKN 3259

Query: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDL-KTKESVGRRISQ 5786
                  L + +S + E +  +    +   +  + +  GE LLL+    + K ++  ++ +
Sbjct: 3260 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 3319

Query: 5787 LQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSE------DPLPEL 5840
            L++ W+++  + A+   + +  ++   + +  +++L   ++  KA+        DP+ +L
Sbjct: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QL 3378

Query: 5841 HEDLHNEKELIKELEQ---------SLASWTQNLKE-----LQTMKADLTRHV--LVEDV 5884
               L   K ++ E+E+         S A    N  E     ++  KA + +++  + E++
Sbjct: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 3438

Query: 5885 MVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTA 5944
                  +E + ++  +        ++++E   +   +F+    + C+      NK L+  
Sbjct: 3439 QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS------NKNLEKL 3492

Query: 5945 DISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-----EIDDKLNKI 5999
                +E+++ L+   ++ +  F++  ++    G    +  +++  A     E+  ++N  
Sbjct: 3493 RAQ-QEVLQALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSG 3550

Query: 6000 NDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEI 6059
                ++  + IG    +++E F+ +  LD  +  +   + R    L   +       +++
Sbjct: 3551 CVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA-IGRDTDSLQSQI-------EDV 3602

Query: 6060 QKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRN 6119
            +  L +   L+ DIE   A        C  +L +        +   +++   +L+++   
Sbjct: 3603 RLFLNKIHVLKLDIEASEAE-------CRHMLEEE----GTLDLLGLKRELEALNKQCGK 3651

Query: 6120 ICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRF 6179
            +      R+ ++E T    + F        D   +AE   A             ++L  F
Sbjct: 3652 LTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADF 3711

Query: 6180 EAFQR-QIHERLTQLELINKQYRRLARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            + FQ+ Q+     +L+ +N   + L +    D     L+  + E N RW+ L ++V   +
Sbjct: 3712 KMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRI 3771

Query: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI---T 6294
             +L+       +F+   E +L WL + +  + N +      A+ K+ +    +Q++    
Sbjct: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRL 3828

Query: 6295 LNTNK--IDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
            L+  K  +D L   G ++ Q +E  D   I  +LE L     E+  + +   ++L
Sbjct: 3829 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883



 Score =  101 bits (251), Expect = 3e-20
 Identities = 582/3278 (17%), Positives = 1245/3278 (37%), Gaps = 498/3278 (15%)

Query: 813  QAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRE 872
            Q+ +++ ++ +Q         +K++     +   +L    S +EL +   +  Q   Q E
Sbjct: 2091 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL----SPRELTALREKLHQAKEQYE 2146

Query: 873  SPGE---LISKHKEALIISNTKSLAKYLKAVEELKNNVTE-----DIKMSLEEKSRDVCA 924
            +  E   +  K  E  + S  +   +  KA +EL  N  +     D   S+      +  
Sbjct: 2147 ALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206

Query: 925  KWESLHHELSLYVQQLKIDIEKGKLSDNIL--KLEKQINKEKKLIRRGRTKGLIKEHE-- 980
                +       +++  +D   G +  N    KL+KQ    K      R + L+ + +  
Sbjct: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMK-----ARHQELLSQQQNF 2261

Query: 981  --ACFSEEGCLYQLNHHM---------EVLRELCEELPSQKSQQEVK-RLLKDYEQKIER 1028
              A  S +  L Q  H++         + L EL E+  +  +Q E + + ++  + ++++
Sbjct: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK 2321

Query: 1029 LLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK-AMEPTM 1087
             L+   E    L+       ++E  +      G  P +     K     S +  + +  +
Sbjct: 2322 FLQDHKEFESWLE-------RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDL 2374

Query: 1088 KFSLASVLRPLQ-EESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEED 1146
            +F   S  + L  E S  E    + I +L++  D  +D  E +         +   S+  
Sbjct: 2375 RFVTISGQKVLDMENSFKEGKEPSEIGNLVK--DKLKDATERY---------TALHSKCT 2423

Query: 1147 RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDI--KKPFVIKERDTLKERER 1204
            R  S L   L      +N  D+     +     +E  ++D     P V++E+    ++ +
Sbjct: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483

Query: 1205 ELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNI 1264
            E        +E L+   R ++ +E       G   P H+   +       D I  H +++
Sbjct: 2484 EELAEHQVPVEKLQKVARDIMEIE-------GEPAPDHRHVQE-----TTDSILSHFQSL 2531

Query: 1265 QDSIAKQIEICNRLEEPGNFVLKELHPF---------DLHAMQ------NIILKYKTQFE 1309
              S+A++  +  +       V + L            +L   Q       +I +      
Sbjct: 2532 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2591

Query: 1310 GMNHRVQRSEDTLKALEDFLAS-LRTAKLSAEPVTDLSASDTQVAQE-NTLTVKNKEGEI 1367
             +   + R + +L+A  + +   + TA  +   V  L     +V+Q    L ++ +E E 
Sbjct: 2592 KLKQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKES 2649

Query: 1368 HLMK-----DKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEF 1422
             L K     +  +HL   L+   M  K          +  +  F  ++ E +   ++ E 
Sbjct: 2650 SLKKLLPQAEMFEHLSGKLQQF-MENKSRMLASGNQPDQDITHFFQQIQELN---LEMED 2705

Query: 1423 TEEN--------KLLEACIF-----KNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
             +EN          L +C F     ++ + ++N++   +++ K          VK R+K 
Sbjct: 2706 QQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK---------TVKEREKD 2756

Query: 1470 LIRLDKVLDEYEEEKRHLQ----EMANSLPHFKDGRE-KTVNQQCQNTVVLWEN--TKAL 1522
                 + LDE+ +  R  Q    E   S+P  +     K + +Q ++   L ++  +K  
Sbjct: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2816

Query: 1523 VTECLEQCGRVLELLKQYQNFKSILTTLIQ-KEESVISLQASYMGKEN---LKKRIAEIE 1578
            + E +   G  LE L        I     Q K  S++    S +G  N     K + EI+
Sbjct: 2817 LVEEINCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871

Query: 1579 IVKEEFNEHLEVVDKI-NQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINE---KT 1634
                + N   E +  + ++  ++LQ  LN+M+        KEAN ++ +WL+  E   K+
Sbjct: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVH-----KEANSVL-QWLESKEEVLKS 2925

Query: 1635 EDYYENLGRALALWDKLFNLKNVIDEWTEKA--LQKMEL----------HQLTEEDRERL 1682
             D   +  +   +  +  + K  + E  + +  +QK++           +    E+ +++
Sbjct: 2926 MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI 2985

Query: 1683 KEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA 1742
            +EEL    ++ +E +  VA  + L +S+      Q  ES +   +   +           
Sbjct: 2986 QEELNSRWERATEVT--VARQRQLEESASHLACFQAAESQLRPWLMEKE----------L 3033

Query: 1743 LSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLEN 1802
            + G    L  D +    Q    + +LK            +L E  Q IL     + L  +
Sbjct: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQH--EQLNEAAQGILTGPGDVSLSTS 3091

Query: 1803 QIGCLTPELSELKKQYESVSDLFNTKKS------VLQDHFSKLLNDQCKNFNDWFSNIKV 1856
            Q+     EL  + +++  ++D  N++ S      V    + +LL D  +        + V
Sbjct: 3092 QV---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV 3148

Query: 1857 NLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVK-ELIS 1915
                  +    K+ +E+  +  SD   LE  + ++K+  ++   +   + + ++K EL  
Sbjct: 3149 QSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK 3205

Query: 1916 WLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEK 1975
             L      L+ +E +   R   L+ +L    + Q     LR WL +++ +         K
Sbjct: 3206 RLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAK 3265

Query: 1976 TELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEE- 2034
             E   Q+  ++ E+F+     ++   E    E E +++      ++ +TL  QL E++  
Sbjct: 3266 LERL-QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEK-RTLQNQLVELKNH 3323

Query: 2035 -EDKLLPTED------------QSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQ 2081
             E+    T D            Q +     D++ WI++ K  +  L  +   + LE  + 
Sbjct: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383

Query: 2082 KIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLL 2141
            + K ++    +  + +E +   A+     L+  +  D     D    +     +  E+L 
Sbjct: 3384 RSKAMLNEVEKRRSLLEILNSAADI----LINSSEADEDGIRDEKAGINQNMDAVTEEL- 3438

Query: 2142 LEGEKYLQSKE-DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIY---------KKFLKK 2191
                   Q+K   L  M   L++ QE+   ++  ++  K QL+I+          K L+K
Sbjct: 3439 -------QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEK 3491

Query: 2192 AQDLTSLLKELKSQGNYLLECTKN-----------------PSFSEEPWLEIKHLHESLL 2234
             +    +L+ L+ Q +YL   T+                     +++ +LE+K    S  
Sbjct: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551

Query: 2235 QQLQDSVQNLDG-HVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQ 2293
              +++ ++ +   H R  + +   + DL+  LD              D  +++ +++ ++
Sbjct: 3552 VMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAI-------GRDTDSLQSQIEDVR 3603

Query: 2294 ELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEM 2353
               N++ +    ++   A  + + +   ++    +K ++++L  +   L  R  + ++++
Sbjct: 3604 LFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQL 3663

Query: 2354 ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEM 2413
            E  L  +    R  +     T    E +A   V  +  E   + +   D+++ +   V+ 
Sbjct: 3664 ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE--IINQQLADFKMFQKEQVDP 3721

Query: 2414 AMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIK 2473
               K   +N                +Q+   + D       +EEI   +  L  KK A +
Sbjct: 3722 LQMKLQQVNGLGQ----------GLIQSAGKDCDVQGLEHDMEEINARWNTLN-KKVAQR 3770

Query: 2474 PLEQTECLNKTETGALVLHNIGYSAQHLDNLL------QALITLKKNKESQYCVLR-DFQ 2526
              +  E L         LH  G     L+ LL      + LI  +K   ++Y V++   Q
Sbjct: 3771 IAQLQEAL---------LH-CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820

Query: 2527 EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSN 2586
            E     +  ++ LL D+++  V  L +          +A  EK    L +L+ +W  L +
Sbjct: 3821 E-----QKLLQRLLDDRKAT-VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3874

Query: 2587 HVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQ 2646
                  K+L +  +             + K++ +      +F ++  K       +  Q 
Sbjct: 3875 KAAARQKQLEDILV-------------LAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3921

Query: 2647 QHLQ---LRLKSPEERAGNQSMIALTTDL-QATKHGFSVLKGQAELQMKRIWGEKEKKNL 2702
              +Q   +R K+ EE   N +     TD+ QA K G S         +  +    E+  L
Sbjct: 3922 AKIQQQIIRHKALEEDIENHA-----TDVHQAVKIGQS---------LSSLTSPAEQGVL 3967

Query: 2703 EDGINNLKKQWETLEPLHLEAENQIKKCDIRNKM-----KETILWAKNLLGELNPS-IPL 2756
             + I++L+ ++  ++         + +     ++      E + W   +  +L+   +  
Sbjct: 3968 SEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKD 4027

Query: 2757 LPDDILSQIRKCKVT-HDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQY 2815
               D+L +     +  ++ I+ R+++V+   +  +  +   T  E   +   L+ ++ +Y
Sbjct: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRY 4087

Query: 2816 QMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHV 2875
              + + S++  + LE   +  + F +   +    ++E E      + T+  ++       
Sbjct: 4088 ADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE----ELATSGGQSPTGEQIP 4143

Query: 2876 TLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLE-------DQLKNLKIRTNRIQ 2928
              +  QKEL++        + E   + + +N   R  LE       + L  L    N   
Sbjct: 4144 QFQQRQKELKK-------EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQY 4196

Query: 2929 RFIQNTC----NEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
            + + +T     +E++  I+  +Q+ +   A        +R  + L       ++ E    
Sbjct: 4197 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP-----IRLEQDQT 4251

Query: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKE-LEEK----IKQLD 3039
              +L   K   + +++ K   D +     FS   ++     E++K  L+EK    I+Q +
Sbjct: 4252 TAQLQVQKAFSIDIIRHKDSMDEL-----FSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 4306

Query: 3040 TFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCD 3099
                 + +  A L + + +   + +  E   +      E+R L AQ+ S  I+      +
Sbjct: 4307 AISLLNSERYARLERAQVL---VNQFWETYEELSPWIEETRALIAQLPSPAIDH-----E 4358

Query: 3100 EIIKKLNENKTFDDSFKEKE-----ILQI-----KLNAEENDKL---YKVLQNMVLELSP 3146
            ++ ++  E +   +S  E +     +L+I     +LN EE + +   Y+  +NM  ++  
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418

Query: 3147 K------ELDEKNCQ--------DKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC 3192
            +       LDE   Q        DK+E  L  L  + S+L+ P LI  E+  I+     C
Sbjct: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE----C 4474

Query: 3193 EAFQEQVWAEMCSIK-AVTAIEKQREE--NSSEASDVETKLREFEDLQMQLNTSIDLRTN 3249
             +  +    E+  ++ +  A++++ EE    S+ +D +   +E +D   +L+  +    +
Sbjct: 4475 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD---KLDQMVFFWED 4531

Query: 3250 VLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP------LRKQEEL 3303
            +   A E   ++ + +  A +    + A++   + D  +    LE P      +++Q E 
Sbjct: 4532 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIK-DTQDIVHDLESPGIDPSIIKQQVEA 4590

Query: 3304 ESTVAHIQD-LTEKL--------------GMISSPEAKLQLQYTLQELVSKNSAMKEAFK 3348
              T+    D L E+L              G    PE +  +        + N   KE  +
Sbjct: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE 4650

Query: 3349 AQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVS 3408
              E   +  ++     + M + +   + K+ T     M  +        ++L + K    
Sbjct: 4651 KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-----MPPVGTDLNTVKDQLNEMKEFKV 4705

Query: 3409 NLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELK 3468
             +   + E+ KL     L+  + T+     +++           L E    WE   E++ 
Sbjct: 4706 EVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE---------PLTELKHLWENLGEKIA 4756

Query: 3469 QEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVE----KQ 3524
                    ++E   + L   Q  L E+        TEEL +    +    + +E    K 
Sbjct: 4757 HR----QHKLEGALLALGQFQHALEELMSW--LTHTEELLDAQRPISGDPKVIEVELAKH 4810

Query: 3525 QLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKL-------LQKVQKNKEL 3577
             +L   +L    +++ V ++   +    A  + +S++ R   +       LQK ++ ++ 
Sbjct: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870

Query: 3578 VQTEIQERHSFTKEI----IALKNFFQQTTTSFQNMAFQDHP-EKSEQFEELQSILKKGK 3632
            +Q+ +Q+   F  EI    + L     Q + S       +   E+ +   EL S LK  +
Sbjct: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930

Query: 3633 LTFENIMEKLRI------------KYSEMYTIVPAE---IESQVEECRKALEDIDEKISN 3677
             T+  +++K R+            K  +   ++  +   + S++EE +  LE        
Sbjct: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE-------- 4982

Query: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKS------KNIEKAQEIQKKMWDELDLWH 3731
            E L  +  +  +  ++E  N L   E+ L   S        +    E  K   +E++   
Sbjct: 4983 EALNLATEF--QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040

Query: 3732 SKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ-QYQQVSQRAECRTSQLNKATVKMEEY 3790
             ++ ELD     +      Q    + NL++  Q ++++V QR+  R   L+ A  + +++
Sbjct: 5041 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100

Query: 3791 SDLLKSTEAWIENT-SHL-----LANPADYDSLRTLSH 3822
             +  K    W+E+  SHL     ++N  D   L+   H
Sbjct: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH 5138



 Score = 97.4 bits (241), Expect = 4e-19
 Identities = 130/690 (18%), Positives = 276/690 (40%), Gaps = 60/690 (8%)

Query: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
            G++ + L    + +  C E        R + L++ L   + + +EI+    +L + ++ L
Sbjct: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQL 4899

Query: 4657 QQSLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
              S     G  ++  EQL        +L+  E    +L D+G  + L         K E 
Sbjct: 4900 SAS-KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQ 4958

Query: 4715 ---VLDSMWGMLRARYTELSSPF------VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
               +L+  W ++ ++  E  S         TE Q    LQ  +  + + ++ L   ++  
Sbjct: 4959 SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS--LQEFINWLTLAEQSL---NIAS 5013

Query: 4766 TKSKV--ALQAQIENHKVFFQKLVADM--------------LLIQAYSAKILPSLLQNRE 4809
              S +   + +QIE HKVF  ++ A                 L Q     ++ +LL + +
Sbjct: 5014 PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQ 5073

Query: 4810 TFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE 4869
            + W + V       ++S + G  L    ++ ++F E +  L   LE   S L S   +  
Sbjct: 5074 SRWEKVV-------QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE----LEGQIAKLEEQW 4925
              +++  ++S +++ ++ +GGK      T+  G+ L      PE    L+  + ++ ++W
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186

Query: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
             ++  K     H+L+  L     +      L  WL   +  L     +   V  DLD + 
Sbjct: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL----AEDQPVHGDLDLVM 5242

Query: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLP 5045
            + ++    F KE+ +++     +   G +L+     DT  ++  L +   +W  +     
Sbjct: 5243 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 5302

Query: 5046 DIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFR 5105
              Q +L Q   +    R  +  ++ W++  E       ++  P     ++ L+  HKEF 
Sbjct: 5303 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL--PDDTEALQSLIDTHKEFM 5360

Query: 5106 MEMDYKQWIVD-FVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQH 5164
             +++ K+  V+  V    + L+ C  +      T     +  +  ++  V     +  Q 
Sbjct: 5361 KKVEEKRVDVNSAVAMGEVILAVCHPDC----ITTIKHWITIIRARFEEVLTWAKQHQQR 5416

Query: 5165 LEQLLESITESENKIQILNNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAI 5221
            LE  L  +  +   ++ L  W++  E  L    +   P+++  V+ L+ + Q    ++  
Sbjct: 5417 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476

Query: 5222 KSKALDELKQSY--LTLESGAVPLLEDTAS 5249
            K   +D + ++Y    +E    P +E + S
Sbjct: 5477 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRS 5506



 Score = 83.2 bits (204), Expect = 8e-15
 Identities = 385/2184 (17%), Positives = 812/2184 (37%), Gaps = 318/2184 (14%)

Query: 286  KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNE--EK 343
            KD     ++ Q  V+D + W+   K K+ +L    +     +  +SLL      NE  ++
Sbjct: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKR 3395

Query: 344  KSFLDVLSIKRDL----DELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL 399
            +S L++L+   D+     E D+D ++  +A  G++  ++A   +L  A    L +    L
Sbjct: 3396 RSLLEILNSAADILINSSEADEDGIRDEKA--GINQNMDAVTEELQ-AKTGSLEEMTQRL 3452

Query: 400  QEVEELMDEDLSASQDHSQAVTLIQ------------EKMTLFKSLMDRFEHHSNILLTF 447
            +E +E         +     + +              EK+   + ++   E   + L  F
Sbjct: 3453 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3512

Query: 448  ---------ENKDEN---HLPLVPPNKLEEMKRRINN---ILEKKFILLLEFHYYKCLVL 492
                     +  D +   H   V   +  E+K+R+N+   ++E K   + +FH     + 
Sbjct: 3513 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3572

Query: 493  GLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLAR-LDTSFQKCGEIYKN--- 548
              + ++  +LD         +S++  +ED   F+ +   L   ++ S  +C  + +    
Sbjct: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3632

Query: 549  -----LAGECQNINKQYMMVKS-----------------DVCMYRKNIYNVKSTLQKVLA 586
                 L  E + +NKQ   +                   D     K + +  +  ++  A
Sbjct: 3633 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA 3692

Query: 587  C-WA--TYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVV 643
              W   T VE +    A F+  +KE++  +  +      L    +  AG        DV 
Sbjct: 3693 LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQ 3747

Query: 644  GSSISKELRRLNKRWRKLVSKT-----QLEMNLPLMIKKQD--QPTFD---NSGNILSKE 693
            G  +  ++  +N RW  L  K      QL+  L    K QD  +P      ++  +++ +
Sbjct: 3748 G--LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3805

Query: 694  EKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTG----QLKVAKDVEKLIGQVEIW 749
            +  + E+    +    +   Q +    K   +  +  G    Q     D EK+ GQ+E  
Sbjct: 3806 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3865

Query: 750  EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESF----- 804
            E+    +L +     + ++ L+ ++     F E      D L +  + +++ E       
Sbjct: 3866 ESRWTELLSKA---AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3922

Query: 805  ----QHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQ---KEL 857
                Q +    L+  I+     V    VK+  +L +LT  +    +  K++  Q    E+
Sbjct: 3923 KIQQQIIRHKALEEDIENHATDVH-QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3981

Query: 858  ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
            +    R   LL Q  S   L  + +  ++         +L  VE+  ++V       +++
Sbjct: 3982 QDRCCRKAALLDQALSNARLFGEDEVEVL--------NWLAEVEDKLSSVF------VKD 4027

Query: 918  KSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIK 977
              +DV  +  + H  L+  +   K ++++     N   L KQ   E+ L+ + +  G+  
Sbjct: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQA--IKNGQALLKQTTGEEVLLIQEKLDGIKT 4085

Query: 978  EH-EACFSEEGCLYQLNHHMEV--------------LRELCEELPSQKSQQEVKRLLKDY 1022
             + +   +    L  L    ++              LRE+ EEL +   Q      +  +
Sbjct: 4086 RYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 4145

Query: 1023 EQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGG------DPHSEAPFAKS--- 1073
            +Q+ + L K   E H  +  T    S+    +     R G      D + +         
Sbjct: 4146 QQRQKELKKEVME-HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 4204

Query: 1074 DNQPSTEKAMEPTMKFSLAS---------------VLRPLQEESIMEKDYSASINSLLER 1118
                  + A++ + ++  A+                L P++    +E+D + +   + + 
Sbjct: 4205 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----LEQDQTTAQLQVQKA 4260

Query: 1119 YDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISL 1178
            +    DI+ H     K  +   FS   +   +C + + T   V++ +T++  +++E ISL
Sbjct: 4261 FSI--DIIRH-----KDSMDELFSHRSEIFGTCGEEQKT---VLQEKTESLIQQYEAISL 4310

Query: 1179 KLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSD 1238
                         +  ER    ER    Q+ +N   E+ E    L   +E+   L+    
Sbjct: 4311 -------------LNSERYARLERA---QVLVNQFWETYE---ELSPWIEETRALIAQLP 4351

Query: 1239 LPLHKMAIQGFHLIDADRIYQH---LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLH 1295
             P           ID +++ Q    +R +++SIA+     ++L + G   LKEL+P +  
Sbjct: 4352 SPA----------IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP-QLKELNPEEGE 4400

Query: 1296 AMQNIILKYKTQFEGMNHRVQRS---------------------EDTLKALEDFLASLRT 1334
             ++    K +  +  +   V++                      E  L+ LE+  + LR 
Sbjct: 4401 MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRM 4460

Query: 1335 AKLSAEPVTDLSA--SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
              L    V  +    SD + A   T+ ++  +     +K + + L    +  D      E
Sbjct: 4461 PPLIPAEVDKIRECISDNKSA---TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4517

Query: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEE--FTEENKLLEACIFKNNELLKNIQDVQSQI 1450
              D       LD       +      + E  F +  +L E   +    LL  I+D Q  +
Sbjct: 4518 IQDK------LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571

Query: 1451 SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT-VNQQC 1509
              +         +K + ++   + +  D   EE   ++ +   L       EK  V +  
Sbjct: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631

Query: 1510 QNTVVLWENTKALVTECLEQCGRVLELLKQYQN-FKSILTTLIQKEESVISLQASYMGKE 1568
                  WEN      E LE+    ++   QYQ+  +++   L      + ++        
Sbjct: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4691

Query: 1569 NLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPP---FEKEANIIVD 1625
             +K ++ E++  K E  +    ++K+N      Q  L   K  +E       +    +  
Sbjct: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNH-----QGELMLKKATDETDRDIIREPLTELKH 4746

Query: 1626 RWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEE 1685
             W ++ EK       L  AL    +  +    +  W     + ++  +    D + ++ E
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806

Query: 1686 LQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME--SSILNKMEHVQKCLTGESNCHAL 1743
            L  H    ++     A ++ + ++    LE    +  SS+ +++E + +C   ES     
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW--ESVLQKT 4864

Query: 1744 SGSTAELREDLDQAK----------TQIGMTESLLKALSPSDSL------------EIFT 1781
                 +L+  L QA+           ++   ES L A  P+  L            E+++
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4924

Query: 1782 KL---EEIQQQILQQKHSMILLENQIGC---LTPELSELKKQYESVSDLFNTKKSVLQD- 1834
            +L   EE   Q+L +   M+L  +  G        ++ L++++  VS     +KS L++ 
Sbjct: 4925 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984

Query: 1835 -HFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLT-LEGRNSKIK 1892
             + +    +  + F +W +  + +L      S    +V  ++++   F   +     +I 
Sbjct: 4985 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044

Query: 1893 QVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDH 1952
            ++D     +K    K  V  + + LV  +   EK+      R + L+D+ ++  +  +  
Sbjct: 5045 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 5104

Query: 1953 RNLRKWLTNQEEKWKGMEEPGE----------KTELFCQALARKREQFESVAQLNNSLKE 2002
            + L  WL + E       E             K + F + L  K+  +++  +   +LKE
Sbjct: 5105 KKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE 5164

Query: 2003 YGFTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
                 E+   ++     + D++ T+  +  E + + +        F D    ++ W+ ++
Sbjct: 5165 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 5224

Query: 2061 KESL-----------MVLNSSEGKMPLEERIQKIKEII-LLKPEGDARIETIMKQAESSE 2108
            +  L           +V+N  +     ++ + K    + +LK  G   IE         +
Sbjct: 5225 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-----SRDD 5279

Query: 2109 APLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
               V+  L ++S +WD    L+ +  S  E+ L + E +  +   L   L E ++     
Sbjct: 5280 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 5339

Query: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE-CTKNPSFSEEPWLE-I 2226
             AL    +  ++ +  +K+F+KK ++    +    + G  +L  C  +   + + W+  I
Sbjct: 5340 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 5399

Query: 2227 KHLHESLLQQLQDSVQNLDGHVRE 2250
            +   E +L   +   Q L+  + E
Sbjct: 5400 RARFEEVLTWAKQHQQRLETALSE 5423



 Score = 59.7 bits (143), Expect = 1e-07
 Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 32/258 (12%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
            WE +  +  H + K++  L    Q    +  + +WL  TE   E+L   +P S D + IE
Sbjct: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4804

Query: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
            + + +   +      ++A V +VN +  E L++ +  +++ L+SRL  ++  WE+     
Sbjct: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
            +     L+ +L Q Q FH   ++ LL L   +++   +  T        L E  RE +  
Sbjct: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG------GLPETAREQLDT 4918

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGH---------------GEDCIEAEEKVHVIEKKLK 6754
              EL     Q+   +E  N LL KG                 +     E+K HV+  K++
Sbjct: 4919 HMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975

Query: 6755 QLREQVSQDLMALQGTQN 6772
            + + ++ + L      QN
Sbjct: 4976 ERKSKLEEALNLATEFQN 4993



 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 72/337 (21%), Positives = 139/337 (41%), Gaps = 22/337 (6%)

Query: 6524 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 6579
            IT Q      RW  + ++    + +++  L   +Q +     I+ +L  TE +L   + +
Sbjct: 3858 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917

Query: 6580 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
                + IQ+  +R K L+E ++  A D ++A+ +  ++SS     T   E   L  ++  
Sbjct: 3918 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3973

Query: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6697
            L   +   Q         L Q+L   + F +    +L WLA  +++     V D K D  
Sbjct: 3974 LQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 4031

Query: 6698 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6757
             L     + + L +E+V R+  VD   +   +LL +  GE+ +  +EK+  I+ +   + 
Sbjct: 4032 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 4091

Query: 6758 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESR 6817
               S+ L  L+  +  A+   S  E  +G                  + T+ G+  T  +
Sbjct: 4092 VTSSKALRTLEQARQLATKFQSTYEELTGWLREVE----------EELATSGGQSPTGEQ 4141

Query: 6818 VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6854
            +P   + Q+     V+   L L  +  +   L  L+P
Sbjct: 4142 IPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178



 Score = 51.2 bits (121), Expect = 3e-05
 Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 8/234 (3%)

Query: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 6608
            Q  QQ      A   W+ +T+ +L  L   +   D    +L+V++    +I++  D+   
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274

Query: 6609 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
            L    +  S+ F      + T LQ +   L   +EA           L ++ +    F +
Sbjct: 4275 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE 4331

Query: 6669 LSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISN 6728
              + L  W+   + R   A +  P  D   L + + E+ QL + + E +P +D L +I  
Sbjct: 4332 TYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389

Query: 6729 SLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDE 6782
             L  + + E+    EEK    E    Q++E+V Q  +AL    + ++ +  F +
Sbjct: 4390 QLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442



 Score = 50.8 bits (120), Expect = 5e-05
 Identities = 45/199 (22%), Positives = 85/199 (42%), Gaps = 11/199 (5%)

Query: 6542 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 6601
            EL     ++  LQ+   D     +WL+++E ELE   M K  S  + +   +KR     +
Sbjct: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 2365

Query: 6602 AFDTYKALVVSVNVSSKEFLQTESP-----ESTEL----QSRLRQLSLLWEAAQGAVDSW 6652
               ++K  +  V +S ++ L  E+      E +E+    + +L+  +  + A        
Sbjct: 2366 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 2425

Query: 6653 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKE 6712
               L   L Q   F   + +L  W+ + +   +K       +DP  L E      QL++E
Sbjct: 2426 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 2485

Query: 6713 LVERQPQVDMLQEISNSLL 6731
            L E Q  V+ LQ+++  ++
Sbjct: 2486 LAEHQVPVEKLQKVARDIM 2504



 Score = 50.8 bits (120), Expect = 5e-05
 Identities = 48/216 (22%), Positives = 94/216 (43%), Gaps = 18/216 (8%)

Query: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
            D+W+ +  + +  + K+++ L    Q    + A+  WL K E +L   +      D+   
Sbjct: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDL--- 5240

Query: 6590 ELRVKRLQEILKAFDTY----KALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 6645
               V  L +  K F          V  +  S +E ++    ++T ++ +L++LS  W+  
Sbjct: 5241 ---VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 5297

Query: 6646 QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRR 6704
                 S +  L Q+L Q + F      LL WL+ A+   R +  + D     ++L++  +
Sbjct: 5298 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 5357

Query: 6705 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6740
            E M   K++ E++  V+    +   +L   H  DCI
Sbjct: 5358 EFM---KKVEEKRVDVNSAVAMGEVILAVCH-PDCI 5389



 Score = 44.7 bits (104), Expect = 0.003
 Identities = 43/238 (18%), Positives = 100/238 (42%), Gaps = 14/238 (5%)

Query: 6536 EMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR 6595
            E + A  ++       + QQ       + TWL   +++    K     + ++ ++ +++ 
Sbjct: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ--QAKNCPISAKLERLQSQLQE 3275

Query: 6596 LQEILKAFDTYKALVVSVNVSSKEFLQTESP--ESTELQSRLRQLSLLWEAAQGAVDSWR 6653
             +E  K+ + +      +    +  L +  P  E   LQ++L +L   WE         +
Sbjct: 3276 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQ 3335

Query: 6654 GGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT-DPKADPRALLECRRELMQLEKE 6712
              L+  + + Q +    ++L+ W+   K +  +  VT DP     +LL  +  L ++EK 
Sbjct: 3336 SRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK- 3394

Query: 6713 LVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGT 6770
               R+  +++L   ++ L+     ++    +EK  +      Q  + V+++L A  G+
Sbjct: 3395 ---RRSLLEILNSAADILINSSEADEDGIRDEKAGI-----NQNMDAVTEELQAKTGS 3444



 Score = 42.4 bits (98), Expect = 0.016
 Identities = 64/322 (19%), Positives = 125/322 (38%), Gaps = 49/322 (15%)

Query: 6537 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 6596
            M++ +   + L +K+ L+ LN     +T   K  + +LE+         +++   ++K L
Sbjct: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3680

Query: 6597 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLL-------- 6641
             +   A +  +AL       V  +N    +F   +  +   LQ +L+Q++ L        
Sbjct: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740

Query: 6642 -------------------WEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6682
                               W      V      L+++L+ C  F    + LL WLA  + 
Sbjct: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE- 3799

Query: 6683 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 6742
                A+   P A+ + +    +E   L++ L +R+  VDMLQ     +       D  + 
Sbjct: 3800 -ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858

Query: 6743 EEKVHVIEKKLKQL------REQVSQDLMAL-QGTQNPASPLPSFDEVDSGDQPPATSVP 6795
              ++  +E +  +L      R++  +D++ L +     A P+  F  V       +  V 
Sbjct: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918

Query: 6796 APRAK-QFRAVRTTEGEEETES 6816
               AK Q + +R    EE+ E+
Sbjct: 3919 TQTAKIQQQIIRHKALEEDIEN 3940



 Score = 38.1 bits (87), Expect = 0.30
 Identities = 50/230 (21%), Positives = 90/230 (39%), Gaps = 33/230 (14%)

Query: 219  IIHALRPDLIDMKSVKHRSNK-DNLREAFRIAEQELKIPRLLEPEDVDVVDPDEK-SIMT 276
            I+H L    ID   +K +    + ++E      +EL+  R+L  + +      EK  +  
Sbjct: 4570 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629

Query: 277  YVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEN-------------- 322
             + +     ++   T +E   K++DAM      ++ LQ +    +N              
Sbjct: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689

Query: 323  -DTYFKKYNSLLSF-----MESFNEEKKSFLDVLSIKRDLDELDKDHL-----QLREAWD 371
             +T   + N +  F      +    EK +    L +K+  DE D+D +     +L+  W+
Sbjct: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749

Query: 372  GLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQD 415
             L  +I   + KL  AL         L +  +WL   EEL+D     S D
Sbjct: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4799



 Score = 38.1 bits (87), Expect = 0.30
 Identities = 45/255 (17%), Positives = 97/255 (38%), Gaps = 13/255 (5%)

Query: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 6591
            WE +         K++  +Q   Q    + A+  WL  T   +++  M    +D+  ++ 
Sbjct: 4638 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV--IKLCTMPPVGTDLNTVKD 4695

Query: 6592 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAV 6649
            ++  ++E        +  +  +N   +  L+  + E+    ++  L +L  LWE     +
Sbjct: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4755

Query: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
               +  L  +L+    F    + L+ WL   +             DP+ +     +   L
Sbjct: 4756 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI--SGDPKVIEVELAKHHVL 4813

Query: 6710 EKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI----EKKLKQLREQVSQDLM 6765
            + +++  Q  V+ + +  N LL    G+D      ++  +    E  L++  E+  Q   
Sbjct: 4814 KNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873

Query: 6766 ALQGTQNPASPLPSF 6780
             LQ  Q   S +  F
Sbjct: 4874 TLQQAQGFHSEIEDF 4888



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 40/204 (19%), Positives = 86/204 (42%), Gaps = 23/204 (11%)

Query: 6584 SDIQEIELRVKRLQEILKAFDTY---------KALVVSVNVSSKEFLQTESPESTELQSR 6634
            +++Q++  + K L+  LK   T          + ++        + L+    ++  LQ  
Sbjct: 1835 AELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKS 1894

Query: 6635 LRQLSLLWEAA----QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT 6690
            L  +S  W +     Q AV+  +    + L Q        Q+L  W+ + KN    +  +
Sbjct: 1895 LSSVSDTWNSRLLHFQNAVEIEK---TKVLNQHTQLEGRLQDLRAWVGN-KNLILNSKGS 1950

Query: 6691 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK----- 6745
            + + D  +L  C ++   L++ + ER+ Q+D L        I  H +D    + +     
Sbjct: 1951 NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNRQMLRL 2009

Query: 6746 VHVIEKKLKQLREQVSQDLMALQG 6769
            ++ +++  + + EQ +  + ALQG
Sbjct: 2010 LNELQRSFQDILEQTAAQVDALQG 2033


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  203 bits (517), Expect = 4e-51
 Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 39  ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 96

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 97  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 146

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  M+A++ LLLW+Q     Y+ +   +F 
Sbjct: 147 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 184

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PEDVDV 
Sbjct: 185 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 244

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
            PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     +   F+
Sbjct: 245 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 303

Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
           +      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A ++K   
Sbjct: 304 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 356

Query: 387 ALPPPLH 393
            +PP  H
Sbjct: 357 -VPPGYH 362



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1109 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1168

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1229 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1283

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1327

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1382

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1439

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1495

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1496 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1670 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1703

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1704 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1742

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1849

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1967

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2027

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2086

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2087 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2145 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2198 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2234

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2235 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2278

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2339 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2510

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2511 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2552

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2721



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 603  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 662

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 663  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 719

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 720  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 779

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 780  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 836

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 837  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 896

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 897  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 941

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 942  -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 990

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 991  DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1099

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1100 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1146

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1196

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1197 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1234

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1294

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1342

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1403 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1452 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1493

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1494 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1543 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1638

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1639 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1686

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1743

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1859

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1911

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2030

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2209 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2386 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2445 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2558

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2676

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2677 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2734

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2735 ASGFLLDPVRNRRLTVNEAVK 2755



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 935  AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 993

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 994  LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1048

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1108

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1109 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1227

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1228 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1279

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1398

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1514

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1515 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1565

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1677

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1678 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1732

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1733 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1789

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1790 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1845 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2077 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2131

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2132 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2177

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2235 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2289

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2341

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2342 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2390

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2568 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2680

Query: 3736 EL 3737
            EL
Sbjct: 2681 EL 2682



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 269  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 328

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 329  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 387

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 388  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 447

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 448  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 507

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 508  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 557

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 558  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 603

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 604  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 659

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 660  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 711

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 712  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 764

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 765  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 989

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 990  KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1049

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1050 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1339 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1392 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1429

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1605

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1606 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1659

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1711

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1712 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1827

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 1878

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 1879 RLEEQAA 1885



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 955  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 1015 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1074

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1180

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1238

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1239 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1350 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1518

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1519 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1571

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1572 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1684 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1789 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 1905 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 1964 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2016

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 2017 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2069

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2070 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2127

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2128 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2186 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2235

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2293

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2294 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1253 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1312

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1426

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1487 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1526

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1527 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1577

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1578 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1633

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1745

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1801

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1844

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1897

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 1958 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2071

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2127

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2185

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2186 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2302 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2353

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2354 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2469 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2526 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2586 LLAEENQRLREQLQLLE 2602



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1342

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1343 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1376

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1377 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1433 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1541

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1542 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1592

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1593 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1650 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1704

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1705 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1743

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1744 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1792

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1793 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1827

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1880

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1926

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 1927 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1976

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2037 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2060

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2061 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2091

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2149

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2150 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2188

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2189 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2242

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2243 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2297

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2353

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2414 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2517

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2518 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2568 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2628 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2731

Query: 6198 KQ 6199
             Q
Sbjct: 2732 AQ 2733



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1279 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1327 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1445

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1503

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1504 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1556

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1557 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1601

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1602 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1656

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1657 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1706 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1744

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1856

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1914

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 1915 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 1974 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2091

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2092 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2207 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2264 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2319

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2320 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2374

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2375 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2423

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2481

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2482 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2535 QRQQQQMEQE 2544



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1973

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 1974 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2028

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2209 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2373

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2426

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2482

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2483 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2510



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 967  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 1024

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1080

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1316

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1317 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1366

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1475

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1593

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1226

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1227 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1276


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  203 bits (517), Expect = 4e-51
 Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 43  ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 100

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 101 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 150

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  M+A++ LLLW+Q     Y+ +   +F 
Sbjct: 151 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 188

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PEDVDV 
Sbjct: 189 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 248

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
            PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     +   F+
Sbjct: 249 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 307

Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
           +      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A ++K   
Sbjct: 308 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 360

Query: 387 ALPPPLH 393
            +PP  H
Sbjct: 361 -VPPGYH 366



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1113 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1172

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1173 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1232

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1233 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1287

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1331

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1386

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1443

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1444 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1499

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1500 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1613

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1674 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1707

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1708 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1746

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1807 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1853

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1854 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 1914 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1971

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2031

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 2032 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2090

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2091 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2149 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2202 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2238

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2239 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2282

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2342

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2343 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2514

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2515 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2556

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2616

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2617 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2676

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2677 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2725



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 607  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 666

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 667  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 723

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 724  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 783

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 784  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 840

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 841  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 900

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 901  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 945

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 946  -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 994

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 995  DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1050

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1051 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1103

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1104 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1150

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1151 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1200

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1201 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1238

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1298

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1346

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1407 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1456 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1497

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1498 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1546

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1547 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1642

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1643 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1690

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1747

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1863

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1915

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 1916 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1975

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 1976 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2034

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 2035 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2213 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2390 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2449 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2562

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2622

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2623 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2680

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2681 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2738

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2739 ASGFLLDPVRNRRLTVNEAVK 2759



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 939  AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 997

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 998  LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1052

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1053 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1112

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1113 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1171

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1172 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1231

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1232 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1283

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1284 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1343

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1402

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1518

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1519 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1569

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1681

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1682 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1736

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1737 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1793

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1794 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1849 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1960

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2081 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2135

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2136 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2181

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2238

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2239 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2293

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2294 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2345

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2346 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2394

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2572 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2630 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2684

Query: 3736 EL 3737
            EL
Sbjct: 2685 EL 2686



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 273  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 332

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 333  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 391

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 392  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 451

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 452  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 511

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 512  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 561

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 562  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 607

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 608  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 663

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 664  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 715

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 716  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 768

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 769  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 822  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 882  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 942  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 993

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 994  KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1053

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1054 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1102

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1222

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1223 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1282

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1343 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1395

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1396 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1433

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1609

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1610 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1663

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1715

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1716 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1831

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1832 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 1882

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 1883 RLEEQAA 1889



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 959  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1018

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 1019 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1078

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1079 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1138

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1139 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1184

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1242

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1243 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1354 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1522

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1523 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1575

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1576 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1688 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1732

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1733 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1793 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 1909 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 1968 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2020

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 2021 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2073

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2074 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2131

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2132 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2190 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2239

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2297

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2298 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1256

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1257 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1316

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1317 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1376

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1430

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1490

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1491 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1530

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1531 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1581

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1582 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1637

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1749

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1805

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1848

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1901

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 1962 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2075

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2131

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2189

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2190 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2306 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2357

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2358 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2473 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2530 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2589

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2590 LLAEENQRLREQLQLLE 2606



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1346

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1347 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1380

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1381 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1436

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1437 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1490 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1545

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1546 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1596

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1597 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1654 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1708

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1709 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1747

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1748 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1796

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1797 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1831

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1832 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1884

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 1885 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1930

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 1931 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1980

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2041 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2064

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2065 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2095

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2153

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2154 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2192

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2193 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2246

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2247 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2301

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2357

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2418 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2521

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2522 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2572 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2632 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2682 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2735

Query: 6198 KQ 6199
             Q
Sbjct: 2736 AQ 2737



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1223 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1282

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1283 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1330

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1331 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1390

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1449

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1507

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1508 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1560

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1561 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1605

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1606 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1660

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1661 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1709

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1710 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1748

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1749 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1860

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1918

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 1919 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 1978 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2095

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2096 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2211 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2267

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2268 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2323

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2324 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2378

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2379 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2427

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2485

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2486 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2538

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2539 QRQQQQMEQE 2548



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1925

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 1926 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1977

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 1978 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2032

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2213 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2271

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2331

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2332 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2377

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2430

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2486

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2487 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2514



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 971  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 1028

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1084

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1085 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1144

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1145 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1203

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1204 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1263

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1264 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1320

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1321 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1370

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1479

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1597

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1111 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1170

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1171 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1230

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1231 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1280


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  203 bits (517), Expect = 4e-51
 Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 7   ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 64

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 65  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 114

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  M+A++ LLLW+Q     Y+ +   +F 
Sbjct: 115 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 152

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PEDVDV 
Sbjct: 153 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 212

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
            PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     +   F+
Sbjct: 213 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 271

Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
           +      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A ++K   
Sbjct: 272 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 324

Query: 387 ALPPPLH 393
            +PP  H
Sbjct: 325 -VPPGYH 330



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1077 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1136

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1137 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1196

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1197 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1251

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1295

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1350

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1351 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1407

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1408 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1463

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1464 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1577

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1638 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1671

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1672 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1710

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1771 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1817

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1818 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 1878 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 1935

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 1995

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 1996 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2054

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2055 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2113 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2166 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2202

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2203 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2246

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2306

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2307 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2478

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2479 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2520

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2580

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2581 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2640

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2641 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2689



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 571  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 630

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 631  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 687

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 688  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 747

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 748  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 804

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 805  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 864

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 865  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 909

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 910  -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 958

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 959  DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1014

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1015 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1067

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1068 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1114

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1115 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1164

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1165 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1202

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1262

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1263 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1310

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1371 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1420 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1461

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1462 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1510

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1511 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1606

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1607 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1654

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1711

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1827

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 1879

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 1880 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1939

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 1940 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 1998

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 1999 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2177 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2354 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2413 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2526

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2586

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2587 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2644

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2645 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2702

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2703 ASGFLLDPVRNRRLTVNEAVK 2723



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 903  AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 961

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 962  LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1016

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1017 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1076

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1077 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1135

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1136 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1195

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1196 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1247

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1248 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1307

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1366

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1482

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1483 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1533

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1534 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1645

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1646 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1700

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1701 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1757

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1758 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1813 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1924

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2045 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2099

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2100 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2145

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2202

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2203 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2257

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2258 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2309

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2310 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2358

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2536 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2594 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2648

Query: 3736 EL 3737
            EL
Sbjct: 2649 EL 2650



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 237  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 296

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 297  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 355

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 356  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 415

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 416  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 475

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 476  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 525

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 526  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 571

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 572  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 627

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 628  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 679

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 680  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 732

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 733  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 786  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 846  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 906  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 957

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 958  KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1017

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1018 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1066

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1186

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1187 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1246

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1307 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1359

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1360 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1397

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1573

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1574 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1627

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1679

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1680 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1795

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1796 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 1846

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 1847 RLEEQAA 1853



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 923  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 982

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 983  PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1042

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1043 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1102

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1103 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1148

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1206

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1207 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1257

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1318 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1486

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1487 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1539

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1540 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1652 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1696

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1697 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1757 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 1873 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 1932 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 1984

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 1985 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2037

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2038 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2095

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2096 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2154 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2203

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2261

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2262 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1160

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1161 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1220

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1221 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1280

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1281 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1340

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1394

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1395 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1454

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1455 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1494

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1495 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1545

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1546 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1601

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1713

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1769

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1812

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 1865

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 1926 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2039

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2095

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2153

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2154 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2270 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2321

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2322 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2436

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2437 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2494 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2553

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2554 LLAEENQRLREQLQLLE 2570



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1310

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1311 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1344

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1345 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1400

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1401 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1454 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1509

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1510 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1560

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1561 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1618 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1672

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1673 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1711

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1712 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1760

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1761 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1795

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1796 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 1848

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 1849 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 1894

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 1895 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 1944

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2005 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2028

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2029 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2059

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2117

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2118 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2156

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2157 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2210

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2211 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2265

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2321

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2382 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2485

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2486 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2536 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2596 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2646 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2699

Query: 6198 KQ 6199
             Q
Sbjct: 2700 AQ 2701



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1187 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1246

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1247 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1294

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1295 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1354

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1413

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1414 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1471

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1472 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1524

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1525 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1569

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1570 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1624

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1625 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1673

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1674 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1712

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1713 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1824

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 1882

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 1883 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 1942 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2059

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2060 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2175 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2231

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2232 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2287

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2288 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2342

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2343 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2391

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2449

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2450 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2502

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2503 QRQQQQMEQE 2512



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1889

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 1890 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 1941

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 1942 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 1996

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2177 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2235

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2295

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2296 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2341

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2394

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2450

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2451 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2478



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 935  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 992

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 993  EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1048

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1049 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1108

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1109 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1167

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1168 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1227

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1228 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1284

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1285 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1334

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1394

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1395 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1443

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1561

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1075 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1134

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1135 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1194

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1195 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1244


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  203 bits (517), Expect = 4e-51
 Identities = 131/367 (35%), Positives = 190/367 (51%), Gaps = 44/367 (11%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK FT W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 176 ERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 233

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 283

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  M+A++ LLLW+Q     Y+ +   +F 
Sbjct: 284 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 321

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PEDVDV 
Sbjct: 322 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 381

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
            PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     +   F+
Sbjct: 382 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 440

Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
           +      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A ++K   
Sbjct: 441 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 493

Query: 387 ALPPPLH 393
            +PP  H
Sbjct: 494 -VPPGYH 499



 Score =  103 bits (257), Expect = 6e-21
 Identities = 333/1789 (18%), Positives = 666/1789 (37%), Gaps = 269/1789 (15%)

Query: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRL-------DKVLDEYEEEKRHLQEMANSLPHFKD 1499
            + Q+ +      T+P ++  K SL +L           D   +E R  QE+   L     
Sbjct: 1246 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG 1305

Query: 1500 GREKTVNQQCQNTVVLWENTKALVTEC------LEQCGRVLELLKQYQN-FKSILTTLIQ 1552
             R+  V +  +    L E  +A++ +       LEQ GR L   ++  +   + L    +
Sbjct: 1306 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1365

Query: 1553 KEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
            ++E + ++  +    + +++++ + + + EE   H E V++  +  K    Y+N +K +E
Sbjct: 1366 RQEQIQAMPLA--DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ---YINAIKDYE 1420

Query: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
                  +A +          K +   E+                VI E+ +      EL 
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKVQSGSES----------------VIQEYVDLRTHYSELT 1464

Query: 1673 QLTE-------EDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILN 1725
             LT        E   R++EE ++ EQ+ +E   R+AE++  L+      + Q+ E+    
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-----QRQLAEAHAQA 1519

Query: 1726 KMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEE 1785
            K +  ++    +           E   D  Q K  I   +  L+ L  S   EI  K  +
Sbjct: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQ 1576

Query: 1786 ----------IQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDH 1835
                      I+++I   +  +   E Q G    EL  L+ + E        +K   Q+ 
Sbjct: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA----EAQKRQAQEE 1632

Query: 1836 FSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVD 1895
             ++ L  Q ++ +      +V L     +S  K   E   +K      LE    + ++ +
Sbjct: 1633 -AERLRRQVQDESQRKRQAEVEL-----ASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686

Query: 1896 SVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQ----LLRLQDD 1951
              L+  +    +     L +     E EL+   +    +  +LE SLQ+    + +L+++
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746

Query: 1952 HRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
                 +     E   +  E   E+ +L      R R Q E VAQ  +  +     ++EE 
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806

Query: 2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSE 2071
              EA       +  +RQ                   +LA   +   +++ E         
Sbjct: 1807 EREARRRGKAEEQAVRQ------------------RELAEQELEKQRQLAEG-------- 1840

Query: 2072 GKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131
                 ++R+   +E+I L+ E         +Q E  +  L+++ L  +  +         
Sbjct: 1841 ---TAQQRLAAEQELIRLRAE--------TEQGE-QQRQLLEEELARLQRE--------- 1879

Query: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK 2191
               + Q++  LE E      E   L+  + + ++E+    +   Q  +A+   +++  ++
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939

Query: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
            A  L +L +E K Q     E         E             + L + +  +    R  
Sbjct: 1940 AARLRALAEEAKRQRQLAEEDAARQRAEAE-------------RVLAEKLAAIGEATRLK 1986

Query: 2252 DSYQVCVTDLNTTLDNFSK--EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKI 2309
               ++ + +     +   +  E  +F  + +++ A + K    + L       D  L++ 
Sbjct: 1987 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046

Query: 2310 LALAKSVKQNTSSVGQKI--IKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRST 2367
              L +   +    V ++I  +K   +     + +LE  L   +   E  L S  K +   
Sbjct: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAEL 2104

Query: 2368 EKKGKFTLPGREKQATSDVQESTQESAAVE-------------------KLEEDWEINKD 2408
            E   +  L   E++   + +E  Q+S A E                   K+EE   + + 
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER 2164

Query: 2409 SAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK 2468
            +  E A   QL+  A +     E++     +Q +  EL   L+ EQ   +++L  + EA 
Sbjct: 2165 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ-SVLDQLRGEAEAA 2223

Query: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
            + A +  E+     + E  A         A+ L    +     +   ++    LR   E 
Sbjct: 2224 RRAAEEAEEARV--QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281

Query: 2529 LAAVES-SMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEK----DSLGNLKIKWEN 2583
             AA  + + +A L  K++       +   ++K KKF     ++K      L  L+++ E 
Sbjct: 2282 EAARRAQAEQAALRQKQA-------ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334

Query: 2584 LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQ 2643
                 TD  K LL+ ++++L+                   E  E     ++V++   S++
Sbjct: 2335 -----TDHQKNLLDEELQRLK------------------AEATEAARQRSQVEEELFSVR 2371

Query: 2644 QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLE 2703
             Q + L  +LK+  E A N+++I    D             Q  LQ +    EK K+  E
Sbjct: 2372 VQMEELS-KLKARIE-AENRALILRDKD-----------NTQRFLQEE---AEKMKQVAE 2415

Query: 2704 DGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD-IL 2762
            +         E      L  E+  ++  +  KM +  + A      L     LL     L
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2475

Query: 2763 SQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKS 2822
            +Q +  ++  D    ++Q  + LAEE +    +L       L  + E  R + ++  +  
Sbjct: 2476 AQEQARRLQED----KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531

Query: 2823 TQRSQQLEFK--LEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHHHVT 2876
             Q   + + +   ++       + + +L  QE  TL+    I R ++      L+     
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591

Query: 2877 LEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
            LE  +++LQ+    +    +E+  + +E  + E   L+    + K    + +RFI+    
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE---- 2647

Query: 2937 EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCIL 2996
              + K K  + F ++ +  Q+  +  QR +  + QE            + RL A     +
Sbjct: 2648 --QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE------------RQRLVA----SM 2689

Query: 2997 QVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEK----IKQLDTFEEEHGKYQALL 3052
            +  + ++     G+     +L QL+ Q  ++E+ L E+     +QL   EE+H    A  
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2749

Query: 3053 SKMRAIDLQIKKMT---EVVLKAPDSSPESRR----LNAQILSQRIEKAKCLCDEIIKKL 3105
             ++ A  +   K        L  P +  E       L  ++ +QR+++A  L  E +++L
Sbjct: 2750 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2809

Query: 3106 NENKTFDDSFKEKEILQIKLNAEE----------NDKL--YKVLQNMVL 3142
             +  T  D    +E ++  L              N+KL  Y  LQ  +L
Sbjct: 2810 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLL 2858



 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 421/2361 (17%), Positives = 867/2361 (36%), Gaps = 398/2361 (16%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 740  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 799

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   ++    H++
Sbjct: 800  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIE---AHLK 856

Query: 2250 EHDSYQVCVTDLNTTLDNFSKEFVSFS-----DKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K   +       D+      +E+ LQ  Q+ + +L+   G
Sbjct: 857  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 916

Query: 2305 TLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ-CKQKDLENRLASAKQEMECCLNS---- 2359
             L  +   AK+V Q         ++  +  L  C  K +E    +  +  EC L      
Sbjct: 917  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE---VTVHKGDECQLVGPAQP 973

Query: 2360 ----ILKSKRSTEKKGK--FTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAV-- 2411
                +L S  S        F +P   ++A   V     +  A+  L     ++  S +  
Sbjct: 974  SHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 1033

Query: 2412 -----EMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLE 2466
                 ++ + +  SL    ++K  E  + ++ L+   L     LR+ Q            
Sbjct: 1034 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE---LHYQAFLRDSQ------------ 1078

Query: 2467 AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALIT-LKKNKESQYCV--LR 2523
                   P          E   +     G  + H   LLQ+L    ++    Q C+  L+
Sbjct: 1079 -DAGGFGP----------EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1127

Query: 2524 DFQEYLAAVESSMKALLT---DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK 2580
            D +  L A E+     L    DKE  +    +    + + +K  A +E     +  L  +
Sbjct: 1128 DIRLQLEACETRTVHRLRLPLDKEPAR----ECAQRIAEQQKAQAEVEGLGKGVARLSAE 1183

Query: 2581 WEN-LSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639
             E  L+          L S+++      EQV        S   +  ++  T+   ++ T+
Sbjct: 1184 AEKVLALPEPSPAAPTLRSELELTLGKLEQVR-------SLSAIYLEKLKTISLVIRGTQ 1236

Query: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
             + +  + H        E+    Q++ A   +L+ATK     L+ QAE Q          
Sbjct: 1237 GAEEVLRAH-------EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF------ 1283

Query: 2700 KNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPD 2759
              L D +   ++  E L+  H E + ++++   R ++ + +   + +L + +        
Sbjct: 1284 DALRDELRGAQEVGERLQQRHGERDVEVERW--RERVAQLLERWQAVLAQTD-------- 1333

Query: 2760 DILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLV 2819
                              RQ+ +E L  +++    S        L   L+D R + + + 
Sbjct: 1334 -----------------VRQRELEQLGRQLRYYRES-----ADPLGAWLQDARRRQEQIQ 1371

Query: 2820 LKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAAT-EAELKHHHVTLE 2878
                  SQ +  +L +       I +    V+E +      +      E +L  +   LE
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE 1431

Query: 2879 --ASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCN 2936
              AS  +  ++ SG  + +QE  +            L      L   T++  +FI  T  
Sbjct: 1432 PVASPAKKPKVQSGSESVIQEYVD------------LRTHYSELTTLTSQYIKFISETLR 1479

Query: 2937 EVEHKIKFCRQFH-EKTSALQEEADSIQRNELLLNQ------EVNKGVKEEIYNLKDRLT 2989
             +E + +   Q   E+   L E   ++++   L         +  +  KE    +++ + 
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539

Query: 2990 AIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQ 3049
              +   +   + K+           S  ++LQ      E E++ K +Q +  E    + +
Sbjct: 1540 RREEAAVDAQQQKR-----------SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588

Query: 3050 ALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENK 3109
                ++R + LQ        L+A +          Q L  R E+A     E  K+  +  
Sbjct: 1589 ---EEIRVVRLQ--------LEATERQRGGAEGELQALRARAEEA-----EAQKRQAQ-- 1630

Query: 3110 TFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIK 3169
                  +E E L+ ++  E   K     +   +EL+ +   E     + + +L  L +++
Sbjct: 1631 ------EEAERLRRQVQDESQRK-----RQAEVELASRVKAEAEAAREKQRALQALEELR 1679

Query: 3170 SQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
             Q ++       ++  + E+    A Q QV  E     A   ++ +R   + + + +E  
Sbjct: 1680 LQAEEA---ERRLRQAEVER----ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732

Query: 3230 LREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNP 3289
            L+E      QL    + R     +A     R +E   R +E    L+A            
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEA----ERAREEAERELER-WQLKA------------ 1775

Query: 3290 EESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKA 3349
             E+L + L+ +E     VA  + L +        EA+ Q +   +E   +  A ++A + 
Sbjct: 1776 NEALRLRLQAEE-----VAQQKSLAQA-------EAEKQKEEAEREARRRGKAEEQAVRQ 1823

Query: 3350 -----QETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK 3404
                 QE E +R L      +++  +      + ET  G+    L     E L RL++  
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQREA 1880

Query: 3405 ALVSNLISTKE-ELMKLR---QILRLLRLRCTENDGICLLKIVSALWE---KWLSLLEAA 3457
            A  +      E EL K+R   ++L   + R  E       K    L     ++  L E A
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940

Query: 3458 KEWEMWCEELKQEWKFVSEEIEREAIILDN-LQEELPEISKTKEAATTEELSELLDCLCQ 3516
                   EE K++ +   E+  R+    +  L E+L  I +     T  E++       +
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA----LKEK 1996

Query: 3517 YGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKE 3576
              EN   ++L      QR R  +   +    +E     + +  +++  +    ++++ K 
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----ERLAQLRKASDS---ELERQKG 2048

Query: 3577 LVQTEIQERHSFTKEIIALKNFFQQTTTS------------------------------- 3605
            LV+  +++R    +EI+ALK  F++                                   
Sbjct: 2049 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 2108

Query: 3606 FQNMAFQDHPEKSEQFEELQSIL-------KKGKLTFENIMEKLRIKYSEMYTIVPAEIE 3658
             + +A ++   + E  E +Q  L       ++ K   E + E+L+ K  E   +     +
Sbjct: 2109 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ 2167

Query: 3659 SQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ-------KSK 3711
                + + A E   +++  E  + + ++A+++K +E+   L   + +L Q         +
Sbjct: 2168 ESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225

Query: 3712 NIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQ 3771
              E+A+E + +   E      ++ E +   Q   EQ   +AQ       +  +  Q+ ++
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285

Query: 3772 RAECRTSQLNK---ATVKMEEYSDLLKST---EAWIE---NTSHLLANPADY------DS 3816
            RA+   + L +   A  +ME++    + T   +A +E    T  L     D+      + 
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345

Query: 3817 LRTLSHHASTVQMALEDSEQKHNLLHSIFMDLEDLS-------------IIFETDELTQS 3863
            L+ L   A+    A     Q    L S+ + +E+LS             I+ + D   + 
Sbjct: 2346 LQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402

Query: 3864 IQE-----------------LSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV 3906
            +QE                  + +   L+Q   E L Q + +A+ ++  + +      R+
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462

Query: 3907 SKIKTIL-----LSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGM 3961
                 +L     L++E      E+  +  + + E  +  ++T+      Q+E+      +
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522

Query: 3962 KPLPVFQ-----------------RTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEE 4004
            K L V +                 +  ++ + +   E  TQE+  L++ +  Q  + D +
Sbjct: 2523 K-LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581

Query: 4005 IENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIER--MEKQILSLNQRKEDLLVDLKA 4062
             E L++ +    A+   E     Q  KL QL+ E  +   ++Q+L   Q  +   +  K 
Sbjct: 2582 AERLREAI----AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637

Query: 4063 TVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEES 4122
            ++L   + ++QE+  +E+     V   +    E+   ++++ +      L A  EE    
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ--ERQRLVASMEEARRR 2695

Query: 4123 SVKSDNGDEKAEPSPQSWSSLWKHDKDM--EEDRASSSSGTIVQE------AYGKISTSD 4174
              +++ G  + +   Q      +  +++  EE++       +++E      A+ +  T+ 
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2755

Query: 4175 NSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEP 4234
               A    P+  +   GP     P  + +G    + A  L  +      E  +++     
Sbjct: 2756 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE--LQRLAQGH 2813

Query: 4235 TEVLHACKTQVAELELWLQQ----ANVAVEPETLNADMQQVLEQQLV--GCQAMLTEIEH 4288
            T V    + +  ++  +LQ     A + ++       +   L++QL+  G   +L E + 
Sbjct: 2814 TTVDELARRE--DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2871

Query: 4289 KVAFLLETCKDQGLGDNGATQ 4309
               FLL+  +++ L  N A +
Sbjct: 2872 ASGFLLDPVRNRRLTVNEAVK 2892



 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 365/1862 (19%), Positives = 727/1862 (39%), Gaps = 232/1862 (12%)

Query: 1994 AQLNNSLKEYGFTEEEEIIME---ATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
            A L +S    GF  E+ ++ E    +C    YQ LL+ L +  +E+           D+ 
Sbjct: 1072 AFLRDSQDAGGFGPEDRLMAEREYGSC-SHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1130

Query: 2051 HDVIHWIKEIKESLMV--LNSSEGKMPLEERIQKIKEIILLKPE------GDARI----E 2098
              +     E  E+  V  L     K P  E  Q+I E    + E      G AR+    E
Sbjct: 1131 LQL-----EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE 1185

Query: 2099 TIMKQAESSEA-PLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLM 2157
             ++   E S A P ++  L     + +    L++ YL   + + L       ++E LR  
Sbjct: 1186 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH 1245

Query: 2158 LIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKE----LKSQGNYLLECT 2213
              +LK+ Q     L   L+  KA LK  +   +  Q     L++     +  G  L +  
Sbjct: 1246 EEQLKEAQAVPATLPE-LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1304

Query: 2214 KNPSFSEEPWLE----IKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFS 2269
                   E W E    +    +++L Q     + L+   R+   Y+     L   L +  
Sbjct: 1305 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1364

Query: 2270 KEFVSFSDKPV-DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKII 2328
            +        P+ D  AV E+L++ Q L   +       +K+    +  KQ  ++     I
Sbjct: 1365 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG---EKVEECQRFAKQYINA-----I 1416

Query: 2329 KDDIKSLQCKQKDLENRLASAKQ-EMECCLNSILKS--KRSTEKKGKFTLPGREKQATSD 2385
            KD    L   +  LE   + AK+ +++    S+++      T      TL  +  +  S+
Sbjct: 1417 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1476

Query: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLE 2445
                 +E   + + +   E  + + VE A+ KQ  L    +    + ER+  ELQ Q ++
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQ 1535

Query: 2446 LDTMLRNEQL-----------EEIEKL----YTQLEAKKAAIKPLEQTECLNKTETGALV 2490
             + + R E             EE+++L      +++AK    +  E++    + E   + 
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595

Query: 2491 LHNIGYSAQH--LDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV 2548
            L       Q    +  LQAL    +  E+Q    R  QE    +   ++     K   + 
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQ---KRQAQEEAERLRRQVQDESQRKRQAE- 1651

Query: 2549 GPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQI---KQLEH 2605
                 V    ++K    +  +++ +L  L    E L     + +++L ++++   +Q++ 
Sbjct: 1652 -----VELASRVKAEAEAAREKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQV 1702

Query: 2606 GWEQVEQQIQKKYSQQVVEYDEFTT-LMNKVQDTEISLQQQQQHLQLRL--KSPEERAGN 2662
              E  ++  + +   +   + E T  L   +Q+  +++ Q ++  + R   ++  ERA  
Sbjct: 1703 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762

Query: 2663 QSMIALTT-DLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHL 2721
            ++   L    L+A +     L+ +   Q K +   + +K  E+     +++         
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG-------- 1814

Query: 2722 EAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQS 2781
            +AE Q  +   + ++ E  L  +  L E      L  +  L ++R    T  G   RQ  
Sbjct: 1815 KAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR--AETEQGEQQRQLL 1869

Query: 2782 VESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERS--NF 2839
             E LA   ++   +  T +  +L   L  +R + ++L L S  R+++      E+S    
Sbjct: 1870 EEELARLQRE--AAAATQKRQELEAELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRL 1926

Query: 2840 FAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQK--ELQEIDSGISTHLQE 2897
             A   +F+ + +E+      R+   A EA+ +      +A+++  E + + +     + E
Sbjct: 1927 EAEAGRFRELAEEA-----ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981

Query: 2898 LTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNE----VEHKIKFCRQFHEKTS 2953
             T +  E  +         LK  +    R++R  ++   +     E   +      E+ +
Sbjct: 1982 ATRLKTEAEI--------ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033

Query: 2954 ALQEEADS-IQRNELLLNQEV--NKGVKEEIYNLK---DRLTAIKCCI-LQVLKLKKVFD 3006
             L++ +DS ++R + L+   +   + V+EEI  LK   ++  A K  + L++ +++   +
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 2093

Query: 3007 YIGLNWDFSQLD-----QLQTQVFEKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDL 3060
                + + ++L+     QL  +   + +E EE++ K L   EE   + +A L ++  +  
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153

Query: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRI---EKAKCLC-----DEIIKKLNENKTFD 3112
            ++++   +  +A   S    +L  +   +R+   EKA          E+ + L + ++  
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 3113 DSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQL 3172
            D  + +   +    A E  +  +V        S ++++E    ++L+ S     Q ++Q 
Sbjct: 2214 DQLRGE--AEAARRAAEEAEEARVQAEREAAQSRRQVEE---AERLKQSAEEQAQARAQA 2268

Query: 3173 QQPLLINLEIKHIQNEKDNCEAFQE---QVWAEMCSIKAVTAIEKQREENSSEASDVETK 3229
            Q              EK   EA QE   +  AE  +++   A + + E++   A   E  
Sbjct: 2269 QAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA---EQT 2314

Query: 3230 LREFEDLQMQLNT------SIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYR 3283
            LR+   ++ +L T        D + N+L+   E L R K   T A    + +E  +   R
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQKNLLD---EELQRLKAEATEAARQRSQVEEELFSVR 2371

Query: 3284 VDVGNPEESLEMPLRKQEE--------LESTVAHIQDLTEKLGMISSPEAKLQLQYTLQE 3335
            V +   EE  ++  R + E         ++T   +Q+  EK+  ++   A+L +    QE
Sbjct: 2372 VQM---EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV--AAQE 2426

Query: 3336 LVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYRE 3395
                    +E    Q   AE+ L+      KM+        K E  L Q    L    +E
Sbjct: 2427 AARLRQLAEEDLAQQRALAEKMLK-----EKMQAVQEATRLKAEAELLQQQKELA---QE 2478

Query: 3396 ALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLE 3455
               RL++ K  ++  ++  EE    ++ L   R R  E         +SA  E+    + 
Sbjct: 2479 QARRLQEDKEQMAQQLA--EETQGFQRTLEAERQRQLE---------MSAEAERLKLRVA 2527

Query: 3456 AAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEISKTKE---AATTEELSELLD 3512
                 +   EE  Q ++  +EEI  +    +   +E   + +T E     +  +   L +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587

Query: 3513 CLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMK----ERCNKLL 3568
             + +     EK Q    LL  +   +Q V +     ET    Q   S K    +R   + 
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647

Query: 3569 QKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDHPEKSEQFEELQSIL 3628
            Q+  K ++L Q E+ +     +E    +   QQ     Q +       +  Q E  + + 
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704

Query: 3629 KKGKLTFENIMEKLRIKYSEMYTIVPAEIESQV----EECRKALEDIDEKISNEV--LKS 3682
            +K +   +  +E+ R +  E+       +  Q+    E+ R AL   +E  +++V   K+
Sbjct: 2705 RKQEELQQ--LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762

Query: 3683 SPS-------YAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHSKLN 3735
             P+        A   + E   +GL       + +   I  A+E+Q+     L   H+ ++
Sbjct: 2763 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR-----LAQGHTTVD 2817

Query: 3736 EL 3737
            EL
Sbjct: 2818 EL 2819



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 339/1747 (19%), Positives = 638/1747 (36%), Gaps = 315/1747 (18%)

Query: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
            Q G++   L  +W+E+ E    L + +    +           EE  +    F +  +  
Sbjct: 406  QDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEME 465

Query: 4888 IGGKHAR------LYQTLNEGKQLVASVSCP------ELEGQIAKLEEQWLSLNKKIDHE 4935
            +  K A       +YQ+L EG      +  P      ++E +  KL    L   K++  E
Sbjct: 466  LPAKEADKNRSKGIYQSL-EGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 524

Query: 4936 LHRLQALLKHLLSYNRDS-------DQLTKWLESSQHTLNYWK--EQSLNVSQDLDTIRS 4986
              RL+ L + +     ++       +Q    L+S    L   K  +++  V +DLD   S
Sbjct: 525  FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 584

Query: 4987 NINNFFEFSKEVDEK-----SSLKTAVISIGNQLLHLKETDTATLRASLA----QFEQKW 5037
             I   F   + + +        +   V  +  +L+ ++      L+A +A    Q  Q  
Sbjct: 585  MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVT 644

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDED-SVHSPSSASQV-- 5094
               + + P++++           + + + ++++W+   +H+    +  V  PS  +Q+  
Sbjct: 645  LQSVQRRPELEDS----------TLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 694

Query: 5095 -KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHR 5153
             + L Q  +EFR +++  +      ++  L  +T         R  + + LG ++ Q+ +
Sbjct: 695  HRGLHQSIEEFRAKIERAR-----SDEGQLSPAT---------RGAYRDCLGRLDLQYAK 740

Query: 5154 VHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQ 5213
            +      +++ LE L   +  +  ++     WL  +EE        +   ++        
Sbjct: 741  LLNSSKARLRSLESLHSFVAAATKELM----WLNEKEEEEVGFDWSDRNTNMTAKKESYS 796

Query: 5214 DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID-ELFQKRSSVLTQVN---QLK 5269
             +  +L +K K + EL+ +      G   L ED  +R   E FQ  +++ TQ +   QL 
Sbjct: 797  ALMRELELKEKKIKELQNA------GDRLLREDHPARPTVESFQ--AALQTQWSWMLQLC 848

Query: 5270 TSMQSVLQEWKIYDQLYDEVN---------MMTIRFWYCMEHSKPVVLSLETLRCQVENL 5320
              +++ L+E   Y Q + +V             +R  Y  + S  V   LE L      L
Sbjct: 849  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT-RLEDL------L 901

Query: 5321 QSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHK--RWTQVNQAIADQLQ 5378
            Q  QDE E       +L E  G L GL      +++ K ++     R      A+ D  Q
Sbjct: 902  QDAQDEKE-------QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954

Query: 5379 KAQSL-----LQL--------WKAYSNAHGEAAA----------------RLKQQEAKFQ 5409
               ++      QL        WK  S++  EAA                  + + EA+ Q
Sbjct: 955  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014

Query: 5410 QLANI----------------------SMSGNNLAEILPPALQDIKELQHDVQKTKEAFL 5447
             L  +                       +   +LA       ++ ++  H ++   +AFL
Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074

Query: 5448 QNSSVL------DRLPQPAE--SSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
            ++S         DRL    E  S +H      L SL++ A  E       +  +  +S+ 
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGAQEE-------SRCQRCISEL 1126

Query: 5500 KDFGVRLESLKGLIMHE----------EENLDRLHQQEKENPD--SFLNHVLALTAQSPD 5547
            KD  ++LE+ +   +H            E   R+ +Q+K   +       V  L+A++  
Sbjct: 1127 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEK 1186

Query: 5548 IEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE-KFLYCCEKWI 5606
            +       L LP    A  TL    R  +  T   LE+   L  I L + K +    +  
Sbjct: 1187 V-------LALPEPSPAAPTL----RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1235

Query: 5607 QLLEKI----EEALKVD--VANSLPELLEQQKTYKMLEAEVSINQTIADSY--------- 5651
            Q  E++    EE LK    V  +LPEL   + + K L A+    Q   D+          
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295

Query: 5652 VTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVEN 5711
            V + LQ            +    ++L +RWQ  +     R+ +++ L RQ + +  S + 
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1355

Query: 5712 LFRFLTDTSHLLSAVKGQE-------RFSLYQTRSLIHELKN---KEIHFQRRRTTCALT 5761
            L  +L D       ++          R  L Q ++L+ E++    K    QR        
Sbjct: 1356 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1415

Query: 5762 LEAGEKLLLTTDLKTK---------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQ 5806
            ++  E  L+T   + +               ESV +    L+  + ++    ++ IK   
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475

Query: 5807 STVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLK 5866
             T+   ++ E+++ E +      +A+  + L E+   L  +++L +   Q+ A   +  K
Sbjct: 1476 ETLRRMEE-EERLAEQQ------RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1528

Query: 5867 ELQT-MKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ELQ  M+ ++ R                     E+  +    +K+ I++ L    +    
Sbjct: 1529 ELQQRMQEEVVRR--------------------EEAAVDAQQQKRSIQEELQQ--LRQSS 1566

Query: 5926 NKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
              E+ A   Q E        I  E  + +LQ +  E     +E +LQ  +   +  +A  
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626

Query: 5986 KSRAAEIDDKLNKINDRWQHLFDV---IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIE 6042
            +    E +    ++ D  Q        + SRVK   E     Q+  + +  LR      E
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686

Query: 6043 SELSKPVVYDVCDDQ---EIQKRLAEQQ-------------DLQRDIEQHSAGVESVFNI 6086
              L +  V      Q   E  +R AE +              L+R +++    V      
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ---- 1742

Query: 6087 CDVLLHDSDACANE-TECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDY 6145
               L  +++  A +  E +  ++       RW+     ++  R++ EE  +  QK L   
Sbjct: 1743 ---LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQ- 1796

Query: 6146 SRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAR 6205
            +  E   + AER A     +E      +E  ++    QRQ+ E   Q        +RLA 
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--------QRLAA 1848

Query: 6206 ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265
            E       RL+    +G Q+   L+  +  + R     T +R+E E     +   +  + 
Sbjct: 1849 EQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905

Query: 6266 LQLTNVEHFSESDADDKMRQLN---GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLI 6322
                  E  S S ++   ++L    G  +E+     ++  L    ++  Q +E  DA   
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQ 1964

Query: 6323 EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRG 6382
              E E +        G  +R            E E    E E + E  R +  D   +R 
Sbjct: 1965 RAEAERVLAEKLAAIGEATRLK---------TEAEIALKEKEAENERLRRLAEDEAFQRR 2015

Query: 6383 ESEEPSS 6389
              EE ++
Sbjct: 2016 RLEEQAA 2022



 Score = 61.2 bits (147), Expect = 3e-08
 Identities = 306/1712 (17%), Positives = 659/1712 (38%), Gaps = 250/1712 (14%)

Query: 4823 EEKSRQCGMKLQSLLQKWEEFDENYASLE------KDLEILISTLPS-------VSLVEE 4869
            E +   C    Q LLQ  E+  +  +  +      KD+ + +    +       + L +E
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151

Query: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVA----SVSCP----ELEGQIAKL 4921
                  +RI+  Q+ +  + G    + +   E ++++A    S + P    ELE  + KL
Sbjct: 1152 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKL 1211

Query: 4922 EEQ------WLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKW------LESSQHTLNY 4969
            E+       +L   K I   +   Q   + L ++     +          LE+++ +L  
Sbjct: 1212 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1271

Query: 4970 WKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRAS 5029
             + Q+       D +R  +    E  + + ++   +              + +    R  
Sbjct: 1272 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER--------------DVEVERWRER 1317

Query: 5030 LAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPS 5089
            +AQ  ++W  ++ Q    Q +L QL  +    R++   + +W+ +   +   E     P 
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR--QEQIQAMPL 1375

Query: 5090 SASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERT--EFAEHLGEM 5147
            + SQ           R ++  +Q +++ + +   ++  C   +K+Y     ++   L   
Sbjct: 1376 ADSQA---------VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1426

Query: 5148 NRQWHRVHGMLNR-KIQH-----LEQLLESITESENKIQILNNWLEAQEERLKTLQKPES 5201
              Q   V     + K+Q      +++ ++  T       + + +++   E L+ +++ E 
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486

Query: 5202 VISVQKLLLDCQDIENQLAIKSKALD---ELKQSYLTLESGAVPLLEDTASRIDELFQKR 5258
            +   Q+      +   +LA    AL+   +L +++   ++ A    ++   R+ E   +R
Sbjct: 1487 LAEQQR-----AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541

Query: 5259 SSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSK-PVVLSLETLRCQV 5317
                    Q K S+Q  LQ+ +   Q  +       R     E S+  +   +  +R Q+
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598

Query: 5318 E-----------NLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            E            LQ+L+  AE +E    + QE   +L+     V +  + K Q   +  
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAEVELA 1655

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
            ++V +A A+  ++ Q  LQ  +       EA  RL+Q E +  +   +++          
Sbjct: 1656 SRV-KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ------ 1708

Query: 5427 PALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLL 5486
                  +  + ++Q  + +F + ++ L+R  Q    +   L        Q+ A  E+   
Sbjct: 1709 ------RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762

Query: 5487 VKANEFE-FVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQS 5545
                E E + L   +   +RL++ +  +  ++       +++KE  +           Q+
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820

Query: 5546 PDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKW 5605
                 L E               Q + +Q   A  TA +R +  Q +          E+ 
Sbjct: 1821 VRQRELAE---------------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1865

Query: 5606 IQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI-------NQTIADSYVTQSLQL 5658
             QLLE+    L+ + A +  +  E +     + AE+ +        +  + S   +S Q 
Sbjct: 1866 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            L+  E     E   E ++L      A +  RQR+   +   RQ  +    +      + +
Sbjct: 1926 LE-AEAGRFRELAEEAARLR---ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981

Query: 5719 TSHLLS----AVKGQE----------RFSLYQTRSLIHELKNKEIHFQRR----RTTCAL 5760
             + L +    A+K +E              +Q R L  +    +   + R    R     
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041

Query: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWK-------DMEPQLAEMIKQFQSTVETWD 5813
             LE  +K L+   L+ +  V   I  L+ S++       ++E +L  +    + T+ + +
Sbjct: 2042 ELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100

Query: 5814 QCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKA 5873
            Q E +     +R + L A+ E    E  E +  +K L  E E++       L+E++ +KA
Sbjct: 2101 QAELE----AARQRQLAAEEERRRREAEERV--QKSLAAE-EEAARQRKAALEEVERLKA 2153

Query: 5874 DLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                   VE+   L+E+ E    +   L    A ++ + E++ + + V  +K +EL   L
Sbjct: 2154 K------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTL 2206

Query: 5934 VQMENKVL----------QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKA 5983
             Q E  VL          + A    EE   + +++  +      E + +LKQ  ++  +A
Sbjct: 2207 -QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQA 2264

Query: 5984 SNKSRAAEIDDKLNKIND--------------RWQHLFDVIGSRVKKLKE-TFAFIQQLD 6028
              +++AA   +KL K  +              R +   D    + KK  E T     Q++
Sbjct: 2265 RAQAQAAA--EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322

Query: 6029 KNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNI-- 6086
            + ++ LR  L   E++  K ++     D+E+Q+  AE  +  R   Q S   E +F++  
Sbjct: 2323 QELTTLRLQLE--ETDHQKNLL-----DEELQRLKAEATEAAR---QRSQVEEELFSVRV 2372

Query: 6087 ----------------CDVLLHDSDACAN--ETECDSIQQTTRSLDRRWRNICAMSMERR 6128
                              ++L D D      + E + ++Q      R   ++ A    R 
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR--LSVAAQEAARL 2430

Query: 6129 MKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTS---AKEELKRFEAFQRQ 6185
             ++ E     Q+ L +    ++ +++ +        +E+L      A+E+ +R +  + Q
Sbjct: 2431 RQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489

Query: 6186 IHERL---TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
            + ++L   TQ      +  R  +   +  A RLK  V E ++     +       ++   
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549

Query: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDAD---DKMRQLNGFQQEITLNTNK 6299
               +    E   +  +  +  +++Q    +H +E   +   +  R+    QQE  L   K
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609

Query: 6300 IDQL-IVFGEQLIQKSEPLDAVLI--EDELEELHRYCQEVFGRVSRFHRRLTSCTPGLED 6356
             +++  V  EQL+Q+++ L    +  +D L +  R+ ++   ++ +  +   +    L +
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669

Query: 6357 EKEASENETDMEDPREIQT--DSWRKRGESEE 6386
            E++  + + + E  R + +  ++ R++ E+EE
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701



 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 284/1577 (18%), Positives = 574/1577 (36%), Gaps = 200/1577 (12%)

Query: 3711 KNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVS 3770
            K +    E Q+  +D L        E+   +Q    +   + + W + +    +++Q V 
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329

Query: 3771 QRAECRTSQLNKATVKMEEYSDLLKSTEAWIENT----SHLLANP-ADYDSLRT------ 3819
             + + R  +L +   ++  Y +      AW+++       + A P AD  ++R       
Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389

Query: 3820 -----LSHHASTVQMALEDSEQKHNLLHSIFMDLEDL---------------------SI 3853
                 +  H   V+     ++Q  N +    + L                        S+
Sbjct: 1390 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1449

Query: 3854 IFETDELTQSIQELSNQVTALQQKIMESLPQIQ---------------RMADDVVAIESE 3898
            I E  +L     EL+   +   + I E+L +++               R+A+   A+E +
Sbjct: 1450 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1509

Query: 3899 VKSMEKRV-SKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLP 3957
             +  E    +K +    +KE+     EE ++  E  ++  +  K++I E +      +L 
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSIQEELQ-----QLR 1563

Query: 3958 QTGMKPLPVFQRTNQLLQDIKL-LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
            Q+    +    R  +  +  +L +E   +     L+   +Q    + E++ L+       
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1623

Query: 4017 AQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQE 4076
            AQ               Q Q E ER+ +Q+   +QRK    V+L + V       K E E
Sbjct: 1624 AQKR-------------QAQEEAERLRRQVQDESQRKRQAEVELASRV-------KAEAE 1663

Query: 4077 GVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPS 4136
               R++  A+ + E    + + +ER+L +        A  E   +  V  +     AE  
Sbjct: 1664 AA-REKQRALQALEELRLQAEEAERRLRQ--------AEVERARQVQVALETAQRSAEAE 1714

Query: 4137 PQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSL 4196
             QS  + +  +K  + +R+       V +   +        A+    +    E   E   
Sbjct: 1715 LQSKRASFA-EKTAQLERSLQEEHVAVAQLREEAERRAQQQAE---AERAREEAERELER 1770

Query: 4197 RPNQTEEGTTPPIEADTL--DSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
               +  E     ++A+ +    S AQ   E + E+   E      A +  V + EL  Q+
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830

Query: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
                 +     A  +   EQ+L+  +A   + E +   L E        +    Q EA A
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE--------ELARLQREAAA 1882

Query: 4315 LSLKLKTVKCNLEKVQ-----MMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESI 4369
             + K + ++  L KV+     ++  +  +E++  +  +KS +    EA +   L+E    
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---- 1938

Query: 4370 VTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQ 4429
               R +   ++  +Q+Q+ E     Q+                  + +    ++ +A  +
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQR-----------------AEAERVLAEKLAAIGE 1981

Query: 4430 ASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYN 4489
            A+  + +   ++   + +N    +    E   + +L      E Q + +   +    +  
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL------EEQAAQHKADIEE-RLAQ 2034

Query: 4490 FRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEE 4549
             R  +  EL+     +ED  ++   ++ +    + ++        EL L L +  S+ E+
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094

Query: 4550 MLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDN 4609
             L      +E    +      LA E ++      ++    L A           LE  + 
Sbjct: 2095 TLRS----KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150

Query: 4610 LQVCLEHT----QAAAVCRSKSLKAGLD-YNRSYQNEIKRLYHQLIKSKTSLQQSLNEIS 4664
            L+  +E      + A    ++ L+   +   +  Q E K     + + +  LQQ+L +  
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-- 2208

Query: 4665 GQSVAEQLQ-KADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGML 4723
             QSV +QL+ +A+A     E AE   A+++ E E        ++E  +L+   +      
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQ-SRRQVEEAERLKQSAEEQ-AQA 2264

Query: 4724 RARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHG----HLKQTKSKVALQAQIENH 4779
            RA+    +     E++Q+A  +   E   + +++ A      H K  +  +  +AQ+E  
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE-- 2322

Query: 4780 KVFFQKLVADMLLIQA--YSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
                Q+L    L ++   +   +L   LQ  +    E   +   +EE+     ++++ L 
Sbjct: 2323 ----QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378

Query: 4838 QKWEEFD-ENYASLEKDLE----ILISTLPSVSLVEETEERL----VERISFYQQIKRNI 4888
            +     + EN A + +D +     L      +  V E   RL     E     Q  + ++
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438

Query: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE-LHRLQALLKHLL 4947
              + A   + L E  Q V        E    K E + L   K++  E   RLQ   + + 
Sbjct: 2439 AQQRALAEKMLKEKMQAVQ-------EATRLKAEAELLQQQKELAQEQARRLQEDKEQM- 2490

Query: 4948 SYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSS-LKT 5006
                 + QL +  +  Q TL   +++ L +S + + ++  +          +E +   + 
Sbjct: 2491 -----AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545

Query: 5007 AVISIGNQL------LHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
                IG +L         K T   TL     Q +     L   + +++ +  +LQ E   
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2605

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME-MDYKQWIVDFV- 5118
             +    EM       + Q   E      S  S+   LLQ+ +    E    +Q   D V 
Sbjct: 2606 LQLKSEEM---QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662

Query: 5119 -NQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESEN 5177
              Q L +      +    ER      + E  R+ H     + RK + L+QL +   + E 
Sbjct: 2663 KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2722

Query: 5178 KIQILNNWLEAQEERLK 5194
             +   N  L  Q + L+
Sbjct: 2723 LLAEENQRLREQLQLLE 2739



 Score = 57.8 bits (138), Expect = 4e-07
 Identities = 346/1742 (19%), Positives = 635/1742 (36%), Gaps = 332/1742 (19%)

Query: 4497 ELKTYTTQLEDLRQEASNLQTQ---ENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEM 4553
            +L TY  QLE +   A   + Q   E++ +E Y++L     EL    SQ +  + E L  
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQE-YVDLRTHYSELTTLTSQYIKFISETLR- 1479

Query: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVC 4613
             R+  E+   +Q   E     L ++  AL  ++                        Q+ 
Sbjct: 1480 -RMEEEERLAEQQRAEERE-RLAEVEAALEKQR------------------------QLA 1513

Query: 4614 LEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLI---KSKTSLQQSLNEISGQSVAE 4670
              H QA A    ++ +   +  +  Q E+ R     +   + K S+Q+ L ++   S AE
Sbjct: 1514 EAHAQAKA----QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1569

Query: 4671 QLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTEL 4730
               KA     + E AE   ++LR E E + +    L+   +     +     LRAR  E 
Sbjct: 1570 IQAKAR----QAEAAER--SRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622

Query: 4731 SSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADM 4790
             +      ++   L+  V+     K +       +  S+V  +A+    K    + + ++
Sbjct: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAE----VELASRVKAEAEAAREKQRALQALEEL 1678

Query: 4791 LLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASL 4850
             L QA  A+     L+  E   A QV     LE   R    +LQS   K   F E  A L
Sbjct: 1679 RL-QAEEAE---RRLRQAEVERARQVQVA--LETAQRSAEAELQS---KRASFAEKTAQL 1729

Query: 4851 EKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVS 4910
            E+ L+       +V+ + E  ER  ++ +  ++ +     +  R     NE  +L     
Sbjct: 1730 ERSLQ---EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786

Query: 4911 CPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYW 4970
                +  +A+ E +     ++ + E  R     +  +   R  +   + LE  +      
Sbjct: 1787 EVAQQKSLAQAEAE--KQKEEAEREARRRGKAEEQAV---RQRELAEQELEKQRQLAEGT 1841

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
             +Q L   Q+L  +R+                         G Q   L E + A L+   
Sbjct: 1842 AQQRLAAEQELIRLRAETEQ---------------------GEQQRQLLEEELARLQREA 1880

Query: 5031 AQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSS 5090
            A   QK   L  +L  ++      +ME L + KA  E  S        TS++      + 
Sbjct: 1881 AAATQKRQELEAELAKVRA-----EMEVLLASKARAEEES------RSTSEKSKQRLEAE 1929

Query: 5091 ASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQ 5150
            A + + L ++    R   +                     E+KR  + + AE   +  RQ
Sbjct: 1930 AGRFRELAEEAARLRALAE---------------------EAKR--QRQLAEE--DAARQ 1964

Query: 5151 WHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
                  +L  K+  + +     TE+E    I     EA+ ERL+ L + E+    Q+  L
Sbjct: 1965 RAEAERVLAEKLAAIGEATRLKTEAE----IALKEKEAENERLRRLAEDEAF---QRRRL 2017

Query: 5211 DCQ------DIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQ 5264
            + Q      DIE +LA   KA D    S L  + G   L+EDT        ++R  V  +
Sbjct: 2018 EEQAAQHKADIEERLAQLRKASD----SELERQKG---LVEDT-------LRQRRQVEEE 2063

Query: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQ 5324
            +  LK S +          +   E+ +  IR      +++  + S E    +    + L 
Sbjct: 2064 ILALKASFEKAAA-----GKAELELELGRIR-----SNAEDTLRSKEQAELEAARQRQLA 2113

Query: 5325 DEAESSEGSWEK-------LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
             E E      E+        +E   + +       E ++ K +   +   +  Q  A QL
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173

Query: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQH 5437
            Q AQ              EAA +  Q E K    A                      +Q 
Sbjct: 2174 QLAQ--------------EAAQKRLQAEEKAHAFA----------------------VQQ 2197

Query: 5438 DVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLS 5497
              Q+ ++   Q  SVLD+L             G   + +RAA                  
Sbjct: 2198 KEQELQQTLQQEQSVLDQLR------------GEAEAARRAA-----------------E 2228

Query: 5498 QFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLK 5557
            + ++  V+ E        + E  +RL Q  +E   +      A      + E   E + +
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARR 2286

Query: 5558 LPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALK 5617
                  A++  Q  + +                     EK     E+ ++   ++E+ L 
Sbjct: 2287 AQAEQAALRQKQAADAEM--------------------EKHKKFAEQTLRQKAQVEQEL- 2325

Query: 5618 VDVANSLPELLEQQKTYK-MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSK 5676
                 +L   LE+    K +L+ E+   +  A     Q  Q+ +  E+ +    + E SK
Sbjct: 2326 ----TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--ELFSVRVQMEELSK 2379

Query: 5677 LTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
            L  R +   + +  R  D D   R  Q+     E + +   + + L  A +   R     
Sbjct: 2380 LKARIEAENRALILR--DKDNTQRFLQE---EAEKMKQVAEEAARLSVAAQEAARLRQLA 2434

Query: 5737 TRSLIHE--LKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDM 5794
               L  +  L  K +  + +    A  L+A  +LL     + KE    +  +LQ+  + M
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ----QQKELAQEQARRLQEDKEQM 2490

Query: 5795 EPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKEL 5854
              QLAE  + FQ T+E   Q + ++     RL++  A+         ED    ++  +E+
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550

Query: 5855 EQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
             + L     +  EL T +    +  LV+ + + ++Q +H   +  +    +   K++++ 
Sbjct: 2551 GEKL-----HRTELATQE----KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601

Query: 5915 RLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEINLFSENKLQLK 5974
                  + +E+ + +    +  E + LQ + +S ++ +  LQ++         + K +L+
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL--LQRE-----RFIEQEKAKLE 2654

Query: 5975 QM-GDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-VKKLKETFAFIQQLDKNMS 6032
            Q+  D++ KA           +L +   R Q   +    R V  ++E      + ++ + 
Sbjct: 2655 QLFQDEVAKA----------QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704

Query: 6033 NLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS--------AGVESVF 6084
              +  L ++E +  +       ++Q ++++L   ++  R    HS        A  +++ 
Sbjct: 2705 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764

Query: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERR--MKIEETWRLWQ--K 6140
            N  D L  D  A   E E         S D   R + A  ++    +  EE  RL Q   
Sbjct: 2765 NGRDAL--DGPAAEAEPE--------HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814

Query: 6141 FLDDYSRFED---WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
             +D+ +R ED   +L+     A       +L  +  E+L  + A QRQ+    T L L+ 
Sbjct: 2815 TVDELARREDVRHYLQGRSSIAG------LLLKATNEKLSVYAALQRQLLSPGTALILLE 2868

Query: 6198 KQ 6199
             Q
Sbjct: 2869 AQ 2870



 Score = 53.1 bits (126), Expect = 9e-06
 Identities = 270/1450 (18%), Positives = 537/1450 (37%), Gaps = 181/1450 (12%)

Query: 4248 LELWLQQANVAVEP-ETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNG 4306
            L  WLQ A    E  + +     Q + +QL   QA+L EIE     + E  +      N 
Sbjct: 1356 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1415

Query: 4307 ATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSEL 4366
               +E     L+L T K  LE V        S  + P +   S     +      + SEL
Sbjct: 1416 IKDYE-----LQLVTYKAQLEPVA-------SPAKKPKVQSGSESVIQEYVDLRTHYSEL 1463

Query: 4367 ESIVTERPQF---SRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQ- 4422
             ++ ++  +F   + ++  +++++ E +  E+++ +  +E   +K       H     Q 
Sbjct: 1464 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1523

Query: 4423 ESSASNQASSPENDV---PDSILSPQGQNG---DKWQYLHHELSSKIKLPLPQLVEPQVS 4476
            E  A       + +V    ++ +  Q Q     ++ Q L     ++I+    Q  E    
Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAER 1582

Query: 4477 TNMGILPSVTMYNFRYPTTEELKTYTT-QLEDLRQEASNLQTQENMTEEAYINLDKKLFE 4535
            + + I   + +   +   TE  +     +L+ LR  A   + Q+   +E    L +++  
Sbjct: 1583 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV-- 1640

Query: 4536 LFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALE-LKKLYLALSDKKGDLLKAMT 4594
                  Q  S  +   E+    R     +    +  AL+ L++L L   + +  L +A  
Sbjct: 1641 ------QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE- 1693

Query: 4595 WPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKT 4654
                     +E    +QV LE  Q +A    +S +A      S+  +  +L   L +   
Sbjct: 1694 ---------VERARQVQVALETAQRSAEAELQSKRA------SFAEKTAQLERSLQEEHV 1738

Query: 4655 SLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
            ++ Q   E   +  A+Q  +A+    E E    R     +E  RL L     +EV + + 
Sbjct: 1739 AVAQLREEAERR--AQQQAEAERAREEAERELERWQLKANEALRLRLQ---AEEVAQQKS 1793

Query: 4715 VLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA 4774
            +  +            +     E++++A  +G  E   + + +LA   L++ +      A
Sbjct: 1794 LAQAE-----------AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1842

Query: 4775 QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQ 4834
            Q        Q+L A+  LI+  +           ET   EQ  + ++LEE+  +   +  
Sbjct: 1843 Q--------QRLAAEQELIRLRA-----------ETEQGEQ--QRQLLEEELARLQREAA 1881

Query: 4835 SLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE----TEERLVERISFYQQIKRNIGG 4890
            +  QK +E +   A +  ++E+L   L S +  EE    T E+  +R+       R +  
Sbjct: 1882 AATQKRQELEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938

Query: 4891 KHARLYQTLNEGK---QLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL 4947
            + ARL     E K   QL    +  +       L E+  ++      E  RL+   +  L
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG-----EATRLKTEAEIAL 1993

Query: 4948 SYNR-DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKT 5006
                 ++++L +  E         +EQ+     D++   + +    +   E++ +  L  
Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVE 2051

Query: 5007 AVI----SIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
              +     +  ++L LK        A  A+ E +   + +   D      Q ++E    R
Sbjct: 2052 DTLRQRRQVEEEILALK-ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110

Query: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ-S 5121
            +   E        E +   +       +A Q K  L++ +  + +++  + + +   Q S
Sbjct: 2111 QLAAEEERRRREAEERV-QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169

Query: 5122 LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQI 5181
              QL      +++  + E   H   + ++   +   L ++   L+QL      +    + 
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE- 2228

Query: 5182 LNNWLEAQEERL----KTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELK------- 5230
                 EA+E R+    +  Q    V   ++L    ++     A    A ++L+       
Sbjct: 2229 -----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283

Query: 5231 -------QSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYD 5283
                   Q+ L  +  A   +E      ++  ++++ V  ++  L+  ++    +  + D
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343

Query: 5284 QLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES---------SEGSW 5334
               +E+  +             V   L ++R Q+E L  L+   E+          + + 
Sbjct: 2344 ---EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400

Query: 5335 EKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH 5394
              LQE   K+K +    A  +    Q   +      + +A Q   A+ +L   K    A 
Sbjct: 2401 RFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAV 2456

Query: 5395 GEAAARLKQQEAKFQQLANISM-SGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVL 5453
             E A RLK +    QQ   ++      L E      Q + E     Q+T EA  Q     
Sbjct: 2457 QE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR---- 2511

Query: 5454 DRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI 5513
             +L   AE+    L         R A + +       + +    Q ++ G +L   + L 
Sbjct: 2512 -QLEMSAEAERLKL---------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE-LA 2560

Query: 5514 MHEEENLDRLHQQEKENPDSFLNHVL-ALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
              E+  L +  + +++  D     +  A+     + E L + +  L L    ++T+Q   
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ-- 2618

Query: 5573 RQWIRATATALERCSELQGIGLNEK-FLYCCEKWI-QLLEKIEEALKVDVANSLPELLEQ 5630
                      L+    LQ   L+EK  L   E++I Q   K+E+  + +VA +     EQ
Sbjct: 2619 -------EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2671

Query: 5631 QKTYKMLEAE 5640
            Q+  + +E E
Sbjct: 2672 QRQQQQMEQE 2681



 Score = 39.7 bits (91), Expect = 0.10
 Identities = 137/698 (19%), Positives = 274/698 (39%), Gaps = 132/698 (18%)

Query: 593  ENLRLLRACFEET-KKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS----- 646
            EN RL R   +E  ++  ++E   +  A      A L +A +  +E    +V  +     
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 2058

Query: 647  -ISKELRRLNKRWRKLVS-KTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDM 704
             + +E+  L   + K  + K +LE+ L  +          N+ + L  +E+A +E +   
Sbjct: 2059 QVEEEILALKASFEKAAAGKAELELELGRIRS--------NAEDTLRSKEQAELEAARQR 2110

Query: 705  SVELPENYNQNIKAGEKHEKE---NEEFTGQLKVA-KDVEKLIGQVEIWEAEAKSVLDQD 760
             +   E   +  +A E+ +K     EE   Q K A ++VE+L  +VE    EA+ + ++ 
Sbjct: 2111 QLAAEEERRRR-EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE----EARRLRERA 2165

Query: 761  DVDTS------MEESLKHLIAKGSMFDELMARSEDMLQMDIQNISS--------QESFQH 806
            + +++       E + K L A+       + + E  LQ  +Q   S         E+ + 
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225

Query: 807  VLTTGLQAKIQEAKEKVQIN-VVKLIAALKNLTDVSPDLDIRLKM--EESQKELESYMMR 863
                  +A++Q  +E  Q    V+    LK   +       + +   E+ +KE E    R
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285

Query: 864  AQQL----LGQRESPGELISKHKE---------ALIISNTKSLAKYLKAVEELKNNVTED 910
              Q     L Q+++    + KHK+         A +     +L   L+  +  KN + E+
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345

Query: 911  IKMSLEEKSRDVCAKWESLHHEL-SLYVQQLKIDIEKGKLS-----------DNILKLEK 958
            ++  L+ ++ +   +   +  EL S+ VQ  ++   K ++            DN  +  +
Sbjct: 2346 LQR-LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404

Query: 959  QINKEKKLIRRGRTKGLIKEHEAC----FSEEGCLYQ-------LNHHMEVLREL----- 1002
            +  ++ K +     +  +   EA      +EE    Q       L   M+ ++E      
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2464

Query: 1003 -CEELPSQK--SQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSEN 1059
              E L  QK  +Q++ +RL +D EQ  ++L              A  T   + T+     
Sbjct: 2465 EAELLQQQKELAQEQARRLQEDKEQMAQQL--------------AEETQGFQRTLEAERQ 2510

Query: 1060 RGGDPHSEAPFAK---SDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASIN--- 1113
            R  +  +EA   K   ++   +  +A E   +F         Q E I EK +   +    
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-------KQAEEIGEKLHRTELATQE 2563

Query: 1114 --SLLERYDTYRDILEHHLQNNKFRITSDFSSEE--DRSSSCLQAKLTDLQVIKNETDAR 1169
              +L++  +  R   +H  +  +  I      +E   + +  LQ K  ++Q ++ E    
Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE---- 2619

Query: 1170 WKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQ 1207
                     +L      +++ F + E+D+L +RER ++
Sbjct: 2620 ---------QLLQETQALQQSF-LSEKDSLLQRERFIE 2647



 Score = 39.3 bits (90), Expect = 0.14
 Identities = 121/693 (17%), Positives = 268/693 (38%), Gaps = 90/693 (12%)

Query: 5800 EMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLA 5859
            ++++  +   +   +C++ I ELK     L+A     +  L   L  +KE  +E  Q +A
Sbjct: 1104 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--DKEPARECAQRIA 1161

Query: 5860 SWTQNLKELQTMKADLTR-HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
               +   E++ +   + R     E V+ L E          +L L +     ++E   + 
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG----KLEQVRSL 1217

Query: 5919 WVVFNEKNKELCAWL--VQMENKVLQTADISIEEM----------------IEKLQKDCM 5960
              ++ EK K +   +   Q   +VL+  +  ++E                 ++KL+    
Sbjct: 1218 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1277

Query: 5961 EEINLFSENKLQLK---QMGDQLIKASNKSRAAEID---DKLNKINDRWQHLFDVIGSRV 6014
             +   F   + +L+   ++G++L +  +  R  E++   +++ ++ +RWQ +      R 
Sbjct: 1278 AQQPTFDALRDELRGAQEVGERL-QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1336

Query: 6015 KKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIE 6074
            ++L++    ++   ++   L  WL        +     + D Q ++++L ++Q L  +IE
Sbjct: 1337 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1396

Query: 6075 QHSAGVESVFNICDVLLH--------------DSDACANETECDSIQQTTRSLDRRWRNI 6120
            +H   VE         ++                +  A+  +   +Q  + S+ + +   
Sbjct: 1397 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY--- 1453

Query: 6121 CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE 6180
                ++ R    E   L  +++   S     ++  ER A    + E      +E L   E
Sbjct: 1454 ----VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE------RERLAEVE 1503

Query: 6181 AF---QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            A    QRQ+ E   Q +   ++  +  ++   +   R ++   +  Q+  ++Q  +  + 
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563

Query: 6238 R----RLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI 6293
            +     ++    Q E  E +R  I   +  + LQL   E           RQ  G + E+
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE-----------RQRGGAEGEL 1612

Query: 6294 TLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRV------SRFHRRL 6347
                 + ++      Q  +++E L    ++DE +   +   E+  RV      +R  +R 
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRR-QVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671

Query: 6348 TSCTPGLEDEKEASE---NETDMEDPREIQT--DSWRKRGESEEPSSPQSLCHLVAPGHE 6402
                  L  + E +E    + ++E  R++Q   ++ ++  E+E  S   S     A   E
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LE 1730

Query: 6403 RSGCETPVSVDSIPLEWDHTGDVGGSSSHEEDE 6435
            RS  E  V+V  +  E +        +    +E
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763



 Score = 35.4 bits (80), Expect = 2.0
 Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 12/171 (7%)

Query: 6572 AELEMLKMAKP-PSDIQEIELR---VKRLQEILKA----FDTYKALVVSVNVSSKEFLQT 6623
            A  E LK A+  P+ + E+E     +K+L+   +A    FD  +  +       +   Q 
Sbjct: 1244 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1303

Query: 6624 ESPESTELQ---SRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASA 6680
                  E++    R+ QL   W+A     D  +  L Q   Q + + + +  L  WL  A
Sbjct: 1304 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1363

Query: 6681 KNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
            + RRQ+     P AD +A+ E  R+   L +E+     +V+  Q  +   +
Sbjct: 1364 R-RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1413


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
           sapiens]
          Length = 1369

 Score =  202 bits (515), Expect = 7e-51
 Identities = 143/455 (31%), Positives = 225/455 (49%), Gaps = 55/455 (12%)

Query: 28  EQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNT 87
           E++  QKK  T W+N  L +  +   ISDL+ D++ GH L+ LLEVLSG  LPR+KG   
Sbjct: 172 ERDRVQKKTSTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 229

Query: 88  FQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQTLSCN 147
           F    N++ AL +LR+R +KL+NI   DI DGNP + LGLIWTIILHF I          
Sbjct: 230 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI---------- 279

Query: 148 YNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNVTDFK 207
                  D+ V   S                  M+A++ LLLW+Q     Y+ +   +F 
Sbjct: 280 ------SDIQVSGQSE----------------DMTAKEKLLLWSQRMVEGYQGLRCDNFT 317

Query: 208 SSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPEDVDVV 267
           SSWR+G  F AIIH  +P LIDM  V  ++N +NL +AF +AE++L + RLL+PEDVDV 
Sbjct: 318 SSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVP 377

Query: 268 DPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFK 327
            PDEKSI+TYV+         P   +  +   +  + W   ++  L  L     +   F+
Sbjct: 378 QPDEKSIITYVSSLYDAMPRVPDVQDGVRAN-ELQLRWQEYRELVLLLLQWMRHHTAAFE 436

Query: 328 KYNSLLSFMESFNEEKKSFLDVLSIKR-DLDELDKDHLQLREAWDGLDHQINAWKIKLNY 386
           +      F  SF E +  +   L  K  +L   + D  + +  +  L+  + A ++K   
Sbjct: 437 ERR----FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK--- 489

Query: 387 ALPP---PLHQTEAWLQEVEELMDED--LSASQDHSQAVTLIQEKMTLFKSLMDRFEHHS 441
            +PP   PL   + W +    +++ +  L +  +  + +  I  K+ +   L +   H +
Sbjct: 490 -VPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQA 548

Query: 442 NILLTFENKDENHLPLVPPNKLEEMKRRINNILEK 476
           + LL      ++ + L+   K+ +    +   L+K
Sbjct: 549 DALL------QSDIRLLAAGKVPQRAGEVERDLDK 577



 Score = 35.0 bits (79), Expect = 2.6
 Identities = 46/210 (21%), Positives = 83/210 (39%), Gaps = 4/210 (1%)

Query: 6057 QEIQKRLAEQQDLQRDIEQHSAGVESVFNICD-VLLHDSDACANETECDSIQQTTRSLDR 6115
            +E  +R+AEQQ  Q ++E    GV  +    + VL     + A  T    ++ T   L+ 
Sbjct: 1150 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE- 1208

Query: 6116 RWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
            + R++ A+ +E+   I    R  Q   +     E+ LK A+   A     E    S K+ 
Sbjct: 1209 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1268

Query: 6176 LKRFEAFQRQIHERLTQLELINKQYRRLAREN--RTDTASRLKQMVHEGNQRWDNLQRRV 6233
              + EA Q        +L    +   RL + +  R     R ++ V +  +RW  +  + 
Sbjct: 1269 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1328

Query: 6234 TAVLRRLRHFTNQREEFEGTRESILVWLTE 6263
                R L     Q   +  + + +  WL +
Sbjct: 1329 DVRQRELEQLGRQLRYYRESADPLGAWLQD 1358



 Score = 33.5 bits (75), Expect = 7.5
 Identities = 42/194 (21%), Positives = 79/194 (40%), Gaps = 17/194 (8%)

Query: 2139 KLLLEGEKYLQSKEDLR---------LMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFL 2189
            KLL   +  L+S E L          LM +  K+++E GF          A+ + Y   +
Sbjct: 736  KLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 795

Query: 2190 KKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVR 2249
            ++ +     +KEL++ G+ LL        + E +        S + QL   +   + H++
Sbjct: 796  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCI---EAHLK 852

Query: 2250 EHDSYQVCVTDLNTTLDNFSK-----EFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDG 2304
            E+ +Y    +D+        K        +  D+      +E+ LQ  Q+ + +L+   G
Sbjct: 853  ENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 912

Query: 2305 TLKKILALAKSVKQ 2318
             L  +   AK+V Q
Sbjct: 913  HLSGLAKRAKAVVQ 926



 Score = 33.1 bits (74), Expect = 9.8
 Identities = 80/406 (19%), Positives = 148/406 (36%), Gaps = 47/406 (11%)

Query: 5423 EILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLE 5482
            EIL       KE++      KEA    S  + +  + A  +  + +P   H L       
Sbjct: 448  EILWSQFLKFKEME---LPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWG 504

Query: 5483 KMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALT 5542
            K+ +      + + S+F+    RLE L+ ++   +     L +++    D+ L   + L 
Sbjct: 505  KLHVAILEREKQLRSEFE----RLECLQRIVTKLQMEAG-LCEEQLHQADALLQSDIRLL 559

Query: 5543 AQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCC 5602
            A     +   EV   L  +D  ++ L N            L+     QG  +  +     
Sbjct: 560  AAGKVPQRAGEVERDLDKADSMIRLLFN--------DVQTLKDGRHPQGEQMYRRVYRLH 611

Query: 5603 EKWIQLLEKIEEALKVDVANSLPELLEQ--QKTYKMLEAEVSINQTIAD--SYVTQSLQL 5658
            E+ + +  +    LK  VA    ++ +   Q   +  E E S  + + D  ++V ++   
Sbjct: 612  ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 671

Query: 5659 LDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTD 5718
            +D  E                 W   +  V  + G   GL +  ++F   +E   R  +D
Sbjct: 672  VDGAE-----------------WGVDLPSVEAQLGSHRGLHQSIEEFQAKIE---RARSD 711

Query: 5719 TSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE 5778
               L  A +G  R  L +      +L N      R   +    + A  K L+  + K +E
Sbjct: 712  EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 771

Query: 5779 SVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKS 5824
             VG         W D    +    + + + +   +  EKKIKEL++
Sbjct: 772  EVGF-------DWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 810


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
           sapiens]
          Length = 2155

 Score =  202 bits (513), Expect = 1e-50
 Identities = 145/454 (31%), Positives = 225/454 (49%), Gaps = 80/454 (17%)

Query: 25  LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD-K 83
           LQ E+E  QKK FT W+NS LAR +    I+DL+TD++ G +L+ LLEVLSG++LP+  K
Sbjct: 35  LQDEREAVQKKTFTKWVNSHLARVSCR--ITDLYTDLRDGRMLIKLLEVLSGERLPKPTK 92

Query: 84  GSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQT 143
           G     C  N++ AL FL+ + + L N+   DI+DGN  + LGLIWTIIL F I+ ++  
Sbjct: 93  GRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVE 152

Query: 144 LSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVNV 203
              N                              + + SA+ ALLLW Q + A Y +VN+
Sbjct: 153 TEDN------------------------------KEKKSAKDALLLWCQMKTAGYPNVNI 182

Query: 204 TDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPED 263
            +F +SWR+GMAF A+IH  RPDLID   +K  +   NL+ AF +AEQ L + +LL+PED
Sbjct: 183 HNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPED 242

Query: 264 VDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDS-EN 322
           + V  PDEKSI+TYV  +  Y                  M  L ++ +++ K+L ++ E 
Sbjct: 243 ISVDHPDEKSIITYVVTYYHYF---------------SKMKALAVEGKRIGKVLDNAIET 287

Query: 323 DTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAWDGLDHQINAWKI 382
           +   +KY SL S +  + E+    L              ++ +   +  G+  Q+ A+  
Sbjct: 288 EKMIEKYESLASDLLEWIEQTIIIL--------------NNRKFANSLVGVQQQLQAFNT 333

Query: 383 KLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFK-----SLMDRF 437
                 PP   +       +E L+    S  + ++Q V + +E   +         +++ 
Sbjct: 334 YRTVEKPPKFTEK----GNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA 389

Query: 438 EHHSNILLTFENKDENHLPLVPPNKLEEMKRRIN 471
           EH   + L  E        L+   KLE++ RR +
Sbjct: 390 EHERELALRNE--------LIRQEKLEQLARRFD 415



 Score = 99.0 bits (245), Expect = 1e-19
 Identities = 303/1650 (18%), Positives = 640/1650 (38%), Gaps = 218/1650 (13%)

Query: 4817 TEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLE-------ILISTLPSVSLVEE 4869
            +++K L  + ++ G  L + ++  E+  E Y SL  DL        I+++     + +  
Sbjct: 265  SKMKALAVEGKRIGKVLDNAIET-EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 323

Query: 4870 TEERLVERISFYQQIKR-----NIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQ 4924
             +++L +  + Y+ +++       G     L+   ++ +     V  P     I+ + + 
Sbjct: 324  VQQQL-QAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKA 382

Query: 4925 WLSLNKK-------IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNV 4977
            W  L K        + +EL R + L +    ++R +     WL  +Q  ++       N 
Sbjct: 383  WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS-----QDNF 437

Query: 4978 SQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
              DL  + +          ++        AV+++  +L      D   + A      + W
Sbjct: 438  GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLW 497

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMI---SWMNNVEHQTSDEDSVHSPSSASQV 5094
              L+  L   +++L       L  +K   EM+    WM+ ++     +D          V
Sbjct: 498  EYLLELLRARRQRLEM----NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY---GKHLLGV 550

Query: 5095 KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRV 5154
            + LLQKH     ++  +   V  VN S  + +T     K  +     + +  M   +  +
Sbjct: 551  EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 610

Query: 5155 HGMLNRKIQHLEQ---LLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              +   +   LE+   L +   E   +      W+  +E+ L +    + + SV +LL  
Sbjct: 611  CQLAAERRARLEESRRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLLSK 666

Query: 5212 CQDIENQLAIKS----KALDELKQSYLTLESGAVPLLE------------DTASRIDELF 5255
             +  E++++ +S    +A+ E +        G+  + E            +  S I +  
Sbjct: 667  HRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKR 726

Query: 5256 QKRSSVLTQ----VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
             + +S+L Q     + +   M  +L+     D  +DE +  ++     ++  K V   + 
Sbjct: 727  LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSL-----VKKHKDVAEEIA 781

Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQ 5371
              R     L +L ++A +      +  +V G+L G+                +R+ +V +
Sbjct: 782  NYR---PTLDTLHEQASALPQEHAESPDVRGRLSGI---------------EERYKEVAE 823

Query: 5372 AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQD 5431
                + Q  Q  L L+K +S A    A  L   E K Q L N+          +P  L+D
Sbjct: 824  LTRLRKQALQDTLALYKMFSEAD---ACELWIDE-KEQWLNNMQ---------IPEKLED 870

Query: 5432 IKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANE 5491
            ++ +QH  +  +      +S +  + Q A    H   P    S +     +  L  + ++
Sbjct: 871  LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP----SEKEIKAQQDKLNTRWSQ 926

Query: 5492 FEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEK-----ENPDSFLNHVLALTAQSP 5546
            F  ++ + KD  +   S++   +   E    + ++ K     ++  + L  V+AL  +  
Sbjct: 927  FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986

Query: 5547 DIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWI 5606
             +E  + V+++  LSD+  K  + +  +        L R +E+  +          E+  
Sbjct: 987  GMER-DLVAIEAKLSDLQ-KEAEKLESEHPDQAQAILSRLAEISDVW---------EEMK 1035

Query: 5607 QLLEKIEEALKVDVANSLPELLEQQKTYK--MLEAEVSINQTIADSYVTQSLQLLDT--- 5661
              L+  E +L    A+ L + L     ++  +   + +I      + +T++ +LL     
Sbjct: 1036 TTLKNREASL--GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN 1093

Query: 5662 --TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT 5719
               EI+N  E   ++ K+ D  +   QG  Q       L ++ Q   T    L +   + 
Sbjct: 1094 IKNEIDNYEE---DYQKMRDMGEMVTQG--QTDAQYMFLRQRLQALDTGWNELHKMWENR 1148

Query: 5720 SHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTD--LKTK 5777
             +LLS     ++F L  T+     L N+E  +    T    TLE  E  +   +  + T 
Sbjct: 1149 QNLLSQSHAYQQF-LRDTKQAEAFLNNQE--YVLAHTEMPTTLEGAEAAIKKQEDFMTTM 1205

Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPL 5837
            ++   +I+ + ++ + +         + Q  V++ D   +K +E  S L +++ +    L
Sbjct: 1206 DANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASEL-LMRLKDNRDL 1264

Query: 5838 PELHEDLH------NEKELIK------ELEQSLASWTQN---LKELQTMKADLTR----- 5877
             +  +D        NEK L        E     + W ++   + EL + K  L +     
Sbjct: 1265 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG 1324

Query: 5878 ----HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                    E   V+KE++  LH+ WE L      + Q + D  N   +F +   +L  WL
Sbjct: 1325 MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWL 1383

Query: 5934 VQMENKVLQTADIS--IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA- 5990
              +E+++ Q+ D    +  +   L+K  M E N     K +++++  Q    S + ++  
Sbjct: 1384 HGLESQI-QSDDYGKDLTSVNILLKKQQMLE-NQMEVRKKEIEELQSQAQALSQEGKSTD 1441

Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA-RIESELSKPV 6049
            E+D K   +  ++  L + +  R   L  +   I Q ++++ +   W+  R+    S   
Sbjct: 1442 EVDSKRLTVQTKFMELLEPLNERKHNLLASKE-IHQFNRDVEDEILWVGERMPLATSTDH 1500

Query: 6050 VYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
             +++   Q +Q  + + Q LQ++I+ H   ++ +F     ++ DS + + E    +I+Q 
Sbjct: 1501 GHNL---QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE----AIRQR 1553

Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
               L + W  +   + +R  ++EE  R  Q++  D +  E W+   E        ++   
Sbjct: 1554 LADLKQLWGLLIEETEKRHRRLEEAHRA-QQYYFDAAEAEAWMSEQELYMMSEEKAKD-E 1611

Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTA-------------SRLK 6216
             SA   LK+ +  ++ + +    +  ++K  R L  ++  ++              + LK
Sbjct: 1612 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK 1671

Query: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE 6276
             +  E   + D   R     L +L    +  E++   RE ++    E+     +V    E
Sbjct: 1672 DLAEERRGKLDERHR-----LFQLNREVDDLEQWIAERE-VVAGSHELGQDYEHVTMLQE 1725

Query: 6277 SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQ------------------LIQKSEPLD 6318
               +      N  Q+ +    +  D+LI  G                    L++  +   
Sbjct: 1726 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1785

Query: 6319 AVLIED-ELEELHRYCQEVFGRVSRFHRRL 6347
             +L    EL + +   +E+FGR+   H++L
Sbjct: 1786 QILAASYELHKFYHDAKEIFGRIQDKHKKL 1815



 Score = 83.6 bits (205), Expect = 6e-15
 Identities = 226/1304 (17%), Positives = 502/1304 (38%), Gaps = 152/1304 (11%)

Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
            +K +ER E AEH  E+          L  ++   E+L +     + K  +   WL   + 
Sbjct: 380  NKAWERLEKAEHEREL---------ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 430

Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG------AVPLLE 5245
             +        + +V+      + IE  +A   + +  +      LE+        +   +
Sbjct: 431  LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490

Query: 5246 DTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKP 5305
            D   R+ E   +      Q  ++   +Q + QE        DE+ ++ +      ++ K 
Sbjct: 491  DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLS----QDYGKH 546

Query: 5306 VVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKR 5365
            ++   + L+        +  +AE   G     Q+     +G  P   ++I ++  +    
Sbjct: 547  LLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFC 606

Query: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
            + ++ Q  A++  + +   +LWK +     E    ++++E    ++ +    G +L  ++
Sbjct: 607  YQELCQLAAERRARLEESRRLWKFFWEM-AEEEGWIREKE----KILSSDDYGKDLTSVM 661

Query: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKML 5485
               L   +  + ++      F Q     + +       +  +    ++  ++ A LE++ 
Sbjct: 662  R-LLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLS 720

Query: 5486 LVKANEFE--FVLSQFK----DFGVRLESLKGLIM-----HEEENLDRLHQQEKENPDSF 5534
             ++    E   +L QF+    D    +  +  ++      H+E +   L ++ K+  +  
Sbjct: 721  AIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI 780

Query: 5535 LNH-----VLALTAQSPDIEHLNEVSLKLPLSDVA-----VKTLQNMNRQWIRATATALE 5584
             N+      L   A +   EH     ++  LS +      V  L  + +Q ++ T    +
Sbjct: 781  ANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYK 840

Query: 5585 RCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
              SE             CE WI   EK +    + +   L +L   Q  ++ LE E++ N
Sbjct: 841  MFSEADA----------CELWID--EKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMN-N 887

Query: 5645 QTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQD 5704
            Q    + V Q  + L  +   +  E   +  KL  RW    + V ++K   D L+     
Sbjct: 888  QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKK---DALLS---- 940

Query: 5705 FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEA 5764
               S++N      +T   +     ++   +  T+ L ++L    +  QR+ T     L A
Sbjct: 941  -ALSIQNYHLECNETKSWIR----EKTKVIESTQDLGNDLAGV-MALQRKLTGMERDLVA 994

Query: 5765 GEKLLLTTDLKTK------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETW 5812
             E  L  +DL+ +            +++  R++++ D W++M+  L    K  ++++   
Sbjct: 995  IEAKL--SDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTL----KNREASLGEA 1048

Query: 5813 DQCEKKIKELK------SRLQVLKAQSEDP--------LPELHEDLHNEKELIKELEQSL 5858
             + ++ +++L       SR Q   A  + P        L   HE++ NE +  +E  Q +
Sbjct: 1049 SKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM 1108

Query: 5859 ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
                + + + QT   D     L + +  L      LH+ WE+        +Q +  + + 
Sbjct: 1109 RDMGEMVTQGQT---DAQYMFLRQRLQALDTGWNELHKMWEN--------RQNLLSQSHA 1157

Query: 5919 WVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE---KLQKDCMEEINLFSENKLQLKQ 5975
            +  F    K+  A+L   E  +  T   +  E  E   K Q+D M  ++   E    + +
Sbjct: 1158 YQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVE 1217

Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
             G +L+   N + +  I +K++ I+DR +   +     + +LK+    +Q+  ++   L 
Sbjct: 1218 TGRRLVSDGNIN-SDRIQEKVDSIDDRHRKNRETASELLMRLKDN-RDLQKFLQDCQELS 1275

Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
             W+   +   ++ + YD  + + +  +  + Q    ++  +   ++ +      L+ +  
Sbjct: 1276 LWINE-KMLTAQDMSYD--EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKP 1332

Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
                ETE   +++    L + W  + + +  +  ++ +  +  + F    +  + WL   
Sbjct: 1333 ----ETEA-VVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGL 1386

Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAREN-------- 6207
            E      +  + L TS    LK+ +  + Q+  R  ++E +  Q + L++E         
Sbjct: 1387 ESQIQSDDYGKDL-TSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1445

Query: 6208 -RTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDL 6266
             R    ++  +++   N+R  NL              + +  +F    E  ++W+ E   
Sbjct: 1446 KRLTVQTKFMELLEPLNERKHNLLA------------SKEIHQFNRDVEDEILWVGERMP 1493

Query: 6267 QLTNVEHFSESDADDKMRQLNG-FQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDE 6325
              T+ +H         + + N   Q+EI  +  +ID +    + ++  S  L A  I   
Sbjct: 1494 LATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQR 1553

Query: 6326 LEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED 6369
            L +L +    +     + HRRL       +   +A+E E  M +
Sbjct: 1554 LADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1597



 Score = 78.2 bits (191), Expect = 3e-13
 Identities = 173/872 (19%), Positives = 347/872 (39%), Gaps = 156/872 (17%)

Query: 4657 QQSLNEISGQSVAEQLQ----KADAYTVELENAESRVAKLRDEGERL-HLPYALLQEVYK 4711
            +Q LN +      E L+    + ++   E+ N  SRVA +     +L H  +   +E+  
Sbjct: 856  EQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915

Query: 4712 LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMV----------------ELVKI-- 4753
             +D L++ W   R          + + ++DALL  +                 E  K+  
Sbjct: 916  QQDKLNTRWSQFRE---------LVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 966

Query: 4754 ----------GKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPS 4803
                      G   L        +  VA++A++ + +   +KL ++        A+ + S
Sbjct: 967  STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE----HPDQAQAILS 1022

Query: 4804 LLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPS 4863
             L      W E  T +K  E    +   KLQ  L+  ++F     S     +  I++   
Sbjct: 1023 RLAEISDVWEEMKTTLKNREASLGEAS-KLQQFLRDLDDFQ----SWLSRTQTAIASEDM 1077

Query: 4864 VSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEE 4923
             + + E E+ L +    ++ IK  I   +   YQ + +  ++V        +GQ    + 
Sbjct: 1078 PNTLTEAEKLLTQ----HENIKNEIDN-YEEDYQKMRDMGEMVT-------QGQT---DA 1122

Query: 4924 QWLSLNKKID------HELHRLQALLKHLLSYN-------RDSDQLTKWLESSQHTLNYW 4970
            Q++ L +++       +ELH++    ++LLS +       RD+ Q   +L + ++ L + 
Sbjct: 1123 QYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHT 1182

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
            +     +   L+   + I    +F   +D       AV+  G +L+     ++  ++  +
Sbjct: 1183 E-----MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1237

Query: 5031 AQFEQKWT----------MLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080
               + +            M +    D+Q+ L   Q           E+  W+N  E   +
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-----------ELSLWIN--EKMLT 1284

Query: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEM-DYKQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
             +D  +  +     K L  KH+ F  E+   K+W+ D + +  +QL    +  K      
Sbjct: 1285 AQDMSYDEARNLHSKWL--KHQAFMAELASNKEWL-DKIEKEGMQL----ISEKPETEAV 1337

Query: 5140 FAEHLGEMNRQWHRVHGMLNRKIQHL--EQLLESITESENKIQILNNWLEAQEERLKTLQ 5197
              E L  +++ W  +      K Q L      E  T+S      L+ WL   E ++++  
Sbjct: 1338 VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQS---CADLDKWLHGLESQIQSDD 1394

Query: 5198 KPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
              + + SV  LL   Q +ENQ+ ++ K ++EL+             L       DE+  K
Sbjct: 1395 YGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ--------AQALSQEGKSTDEVDSK 1446

Query: 5258 RSSVLTQ-------VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSL 5310
            R +V T+       +N+ K ++ +  +  +    + DE+  +  R    +  S     +L
Sbjct: 1447 RLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERM--PLATSTDHGHNL 1504

Query: 5311 ETLRCQVENLQSLQDEAESS----EGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            +T++  ++  Q+LQ E +      +  +E+ Q ++     L    AE I ++  +  + W
Sbjct: 1505 QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS---AEAIRQRLADLKQLW 1561

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQE--------AKFQQLANISMSG 5418
              + +    + ++ +   +  + Y +A  EA A + +QE        AK +Q A +SM  
Sbjct: 1562 GLLIEETEKRHRRLEEAHRAQQYYFDA-AEAEAWMSEQELYMMSEEKAKDEQSA-VSMLK 1619

Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNS 5450
             +  +IL  A++D  E  H + KT  A + +S
Sbjct: 1620 KH--QILEQAVEDYAETVHQLSKTSRALVADS 1649



 Score = 77.8 bits (190), Expect = 3e-13
 Identities = 166/927 (17%), Positives = 359/927 (38%), Gaps = 102/927 (11%)

Query: 5883 DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQ 5942
            D  V+++++ H+   +++LC   A R+  +E+    W  F E  +E   W+ + E K+L 
Sbjct: 592  DPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEE-GWIREKE-KILS 649

Query: 5943 TADI-----SIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLN 5997
            + D      S+  ++ K  +   +E++  S +  Q  + G+ +I A     + +I +++ 
Sbjct: 650  SDDYGKDLTSVMRLLSK-HRAFEDEMSGRSGHFEQAIKEGEDMI-AEEHFGSEKIRERII 707

Query: 5998 KINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQ 6057
             I ++W +L  +   R K+L+E  + + Q   +  ++  W+  I   +S   V    D+ 
Sbjct: 708  YIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSDVGH--DEY 764

Query: 6058 EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRW 6117
              Q  + + +D+  +I  +   ++++      L  +        E   ++     ++ R+
Sbjct: 765  STQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE------HAESPDVRGRLSGIEERY 818

Query: 6118 RNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELK 6177
            + +  ++  R+  +++T  L++ F  +    E W+   E+        E L     E+L+
Sbjct: 819  KEVAELTRLRKQALQDTLALYKMF-SEADACELWIDEKEQWLNNMQIPEKL-----EDLE 872

Query: 6178 ----RFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQ--- 6230
                RFE+ + +++ + +++ ++N+  R+L       +   +K    + N RW   +   
Sbjct: 873  VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP-SEKEIKAQQDKLNTRWSQFRELV 931

Query: 6231 -RRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDK--MRQLN 6287
             R+  A+L  L    N   E   T+     W+ E    + + +      A      R+L 
Sbjct: 932  DRKKDALLSALS-IQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLT 986

Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
            G ++++     K+  L    E+L +   P  A  I   L E+    +E+   +      L
Sbjct: 987  GMERDLVAIEAKLSDLQKEAEKL-ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1045

Query: 6348 TSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHER 6403
                       EAS+ +  + D  + Q  SW  R +    SE+  +  +    +   HE 
Sbjct: 1046 G----------EASKLQQFLRDLDDFQ--SWLSRTQTAIASEDMPNTLTEAEKLLTQHEN 1093

Query: 6404 SGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGHS-----WHVPD 6458
               E    +D+   ++    D+G   +  + +    +     +++  G +     W    
Sbjct: 1094 IKNE----IDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQ 1149

Query: 6459 SPSCPEHHYKQMEGDRN-----------------VPPVPPASSTPYKPPYGKLLLPPGTD 6501
            +     H Y+Q   D                   +P     +    K     +      +
Sbjct: 1150 NLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANE 1209

Query: 6502 GGKEGPRVLNGNPQQEDGGLAG--ITEQQSGAFDRWEMIQ--AQELHNKLKIKQNLQQLN 6557
              K    V  G     DG +    I E+     DR    +  A EL  +LK  ++LQ+  
Sbjct: 1210 E-KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFL 1268

Query: 6558 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--QEILKAFDTYKALVVSVNV 6615
             D   ++ W+       E +  A+  S  +   L  K L  Q  +    + K  +  +  
Sbjct: 1269 QDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1322

Query: 6616 SSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLL 6675
               + +  +      ++ +L  L  +WE  +    +    L  +  + + F Q   +L  
Sbjct: 1323 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDK 1381

Query: 6676 WLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 6735
            WL   +++ Q             LL   ++   LE ++  R+ +++ LQ  + +L  +G 
Sbjct: 1382 WLHGLESQIQSDDYGKDLTSVNILL---KKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1438

Query: 6736 GEDCIEAEEKVHVIEKKLKQLREQVSQ 6762
              D  E + K   ++ K  +L E +++
Sbjct: 1439 STD--EVDSKRLTVQTKFMELLEPLNE 1463



 Score = 77.8 bits (190), Expect = 3e-13
 Identities = 265/1440 (18%), Positives = 537/1440 (37%), Gaps = 197/1440 (13%)

Query: 4959 WLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL 5018
            W+   +  L+     S +  +DL ++   ++    F  E+  +S      I  G  ++  
Sbjct: 640  WIREKEKILS-----SDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE 694

Query: 5019 KETDTATLRASLAQFEQKWTMLITQLPDIQEK-------LHQLQMEKLPSRKAITEMISW 5071
            +   +  +R  +    ++W  L  QL  I++K       LHQ Q +         ++ +W
Sbjct: 695  EHFGSEKIRERIIYIREQWANL-EQLSAIRKKRLEEASLLHQFQADA-------DDIDAW 746

Query: 5072 MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE 5131
            M ++    S  D  H   S      L++KHK+   E+   +  +D +++    L     E
Sbjct: 747  MLDILKIVSSSDVGHDEYSTQS---LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE 803

Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
            S      +    L  +  ++  V  +   + Q L+  L ++ +  ++      W++ +E+
Sbjct: 804  SP-----DVRGRLSGIEERYKEVAELTRLRKQALQDTL-ALYKMFSEADACELWIDEKEQ 857

Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRI 5251
             L  +Q PE +  ++ +    + +E ++  ++  +  + Q    L     P  ++  ++ 
Sbjct: 858  WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 917

Query: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
            D+L  + S     V++ K ++ S L   + Y    +E           +E ++ +   L 
Sbjct: 918  DKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLA 976

Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQV-- 5369
             +      L  ++ +  + E     LQ+   KL+   P  A+ I  +       W ++  
Sbjct: 977  GVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKT 1036

Query: 5370 ----NQAIADQLQKAQSLL------QLWKAYS----------NAHGEAAARLKQQE---- 5405
                 +A   +  K Q  L      Q W + +          N   EA   L Q E    
Sbjct: 1037 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1096

Query: 5406 ---------AKFQQLANISMSGNNLAE--ILPPALQDI----KELQHDVQKTKEAFLQNS 5450
                      K + +  +   G   A+   L   LQ +     EL H + + ++  L  S
Sbjct: 1097 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWENRQNLLSQS 1155

Query: 5451 SVLDRLPQPAESS-----------THMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
                +  +  + +            H  +P  L   + A   ++  +   +  E  ++  
Sbjct: 1156 HAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAV 1215

Query: 5500 KDFGVRLESLKGL----IMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS 5555
             + G RL S   +    I  + +++D  H++ +E     L  +         ++   E+S
Sbjct: 1216 VETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELS 1275

Query: 5556 L-----KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLE 5610
            L      L   D++    +N++ +W++  A   E  S               ++W+  +E
Sbjct: 1276 LWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASN--------------KEWLDKIE 1321

Query: 5611 KIEEALKVDVANSLPELLEQQK---TYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENR 5667
            K  E +++       E + ++K    +KM E   S  QT A        +L D     N+
Sbjct: 1322 K--EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ-------RLFDA----NK 1368

Query: 5668 PEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
             E  T+     D+W + ++   Q + D  G     +D  TSV  L +      + +   K
Sbjct: 1369 AELFTQSCADLDKWLHGLES--QIQSDDYG-----KDL-TSVNILLKKQQMLENQMEVRK 1420

Query: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQL 5787
             +      Q ++L  E K+ +    +R T     +E  E L    + K      + I Q 
Sbjct: 1421 KEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL---NERKHNLLASKEIHQF 1477

Query: 5788 QDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNE 5847
                +D    + E +    ST    +   + ++ L  + Q L+ + +   P + +     
Sbjct: 1478 NRDVEDEILWVGERMPLATSTDHGHNL--QTVQLLIKKNQTLQKEIQGHQPRIDDIFERS 1535

Query: 5848 KELIKELEQ-SLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
            + ++ +    S  +  Q L +L+ +              +L E+ E  HR+ E+     A
Sbjct: 1536 QNIVTDSSSLSAEAIRQRLADLKQLWG------------LLIEETEKRHRRLEE-----A 1578

Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEE-MIEKLQKDCMEE--I 5963
             R Q+          F+    E  AW+ + E  ++       E+  +  L+K  + E  +
Sbjct: 1579 HRAQQ--------YYFDAAEAE--AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAV 1628

Query: 5964 NLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAF 6023
              ++E   QL +    L+ A +   +  I  + +K++  +  L D+   R  KL E    
Sbjct: 1629 EDYAETVHQLSKTSRALV-ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1687

Query: 6024 IQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQ-QDLQRDIEQHSAGVES 6082
              QL++ + +L  W+A  E        +++  D E    L E+ ++  RD    + G E 
Sbjct: 1688 F-QLNREVDDLEQWIAEREVVAGS---HELGQDYEHVTMLQERFREFARD--TGNIGQER 1741

Query: 6083 VFNICDVLLHDSDACANETECD--SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQK 6140
            V    D + H +D   N    D  +I +    L+  W ++  +   R   +  ++ L  K
Sbjct: 1742 V----DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL-HK 1796

Query: 6141 FLDD----YSRFED-WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLEL 6195
            F  D    + R +D   K  E      N+ E L        +    F+  I    TQ+  
Sbjct: 1797 FYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ-------RMHTTFEHDIQALGTQVRQ 1849

Query: 6196 INKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHF-TNQREEFEGTR 6254
            + +   RL      D A  +++  +E  + W +L     +  RR+R   T  +  F    
Sbjct: 1850 LQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACES--RRVRLVDTGDKFRFFSMV 1907

Query: 6255 ESILVWLTEMDLQLTNVEHFSE-SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
              +++W+ ++  Q+   E   + S  +  M    G + EI    +     I  G+ L+ +
Sbjct: 1908 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1967



 Score = 48.9 bits (115), Expect = 2e-04
 Identities = 177/879 (20%), Positives = 349/879 (39%), Gaps = 166/879 (18%)

Query: 2949 HEKTSAL-QEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
            HE+ SAL QE A+S      L       G+ EE Y     LT ++   LQ        D 
Sbjct: 791  HEQASALPQEHAESPDVRGRL------SGI-EERYKEVAELTRLRKQALQ--------DT 835

Query: 3008 IGLNWDFSQLDQLQTQVFEKEK-----ELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQI 3062
            + L   FS+ D  +  + EKE+     ++ EK++ L+  +    ++++L  +M     ++
Sbjct: 836  LALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQH---RFESLEPEMNNQASRV 892

Query: 3063 KKMTEVVLKAPDSS-PESRRLNAQI--LSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKE 3119
              + ++  +   S  P  + + AQ   L+ R  + + L D   KK              E
Sbjct: 893  AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR--KKDALLSALSIQNYHLE 950

Query: 3120 ILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLIN 3179
              + K    E  K+ +  Q++  +L+     ++     +E  L  +    S LQ+     
Sbjct: 951  CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG-MERDLVAIEAKLSDLQKEAE-K 1008

Query: 3180 LEIKHIQNEKDNCEAFQE--QVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQ 3237
            LE +H    +       E   VW EM +        K RE +  EAS ++  LR+ +D Q
Sbjct: 1009 LESEHPDQAQAILSRLAEISDVWEEMKTTL------KNREASLGEASKLQQFLRDLDDFQ 1062

Query: 3238 MQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPL 3297
              L+ +   +T + ++   N       +T A + +T  E I    + ++ N EE  +  +
Sbjct: 1063 SWLSRT---QTAIASEDMPN------TLTEAEKLLTQHENI----KNEIDNYEEDYQ-KM 1108

Query: 3298 RKQEELES---TVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEA 3354
            R   E+ +   T A    L ++L  + +   +L   +  ++ +   S   + F     +A
Sbjct: 1109 RDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQA 1168

Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQS---MSSLPLSYREALERLEQSKALVS--- 3408
            E +L N + Y     ++ T L   E  + +    M+++  +  +    +E  + LVS   
Sbjct: 1169 EAFLNNQE-YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN 1227

Query: 3409 -------------------NLISTKEELMKLR--QILRLLRLRCTENDGICLLKIVSA-- 3445
                               N  +  E LM+L+  + L+     C E       K+++A  
Sbjct: 1228 INSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQD 1287

Query: 3446 --------LWEKWLS----LLEAAKEWEMWCEELKQE-WKFVSEEIEREAII------LD 3486
                    L  KWL     + E A   E W +++++E  + +SE+ E EA++      L 
Sbjct: 1288 MSYDEARNLHSKWLKHQAFMAELASNKE-WLDKIEKEGMQLISEKPETEAVVKEKLTGLH 1346

Query: 3487 NLQEELPEISKTK-EAATTEELSELLDCLC-----------------QYGEN-------V 3521
             + E L   ++TK +       +EL    C                  YG++       +
Sbjct: 1347 KMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL 1406

Query: 3522 EKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTE 3581
            +KQQ+L   +  R + I+ +   + A+      QE  S  E  +K L    K  EL++  
Sbjct: 1407 KKQQMLENQMEVRKKEIEELQSQAQALS-----QEGKSTDEVDSKRLTVQTKFMELLEPL 1461

Query: 3582 IQERHSF--TKEIIAL-KNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
             + +H+   +KEI    ++   +     + M      +     + +Q ++KK +      
Sbjct: 1462 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQ------ 1515

Query: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSS--PSYAMRRKIEEIN 3696
                              ++ +++  +  ++DI E+  N V  SS   + A+R+++ ++ 
Sbjct: 1516 -----------------TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLK 1558

Query: 3697 NGLHNVEKMLQQKSKNIEKAQEIQKKMWD--ELDLWHSK 3733
                 + +  +++ + +E+A   Q+  +D  E + W S+
Sbjct: 1559 QLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1597



 Score = 47.4 bits (111), Expect = 5e-04
 Identities = 253/1414 (17%), Positives = 540/1414 (38%), Gaps = 231/1414 (16%)

Query: 1464 KHRKKSLIRLDKVLDE----YEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENT 1519
            ++  +SL++  K + E    Y      L E A++LP  +      V  +       ++  
Sbjct: 763  EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEERYKEV 821

Query: 1520 KALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEI 1579
              L     +     L L K +    +    + +KE+ + ++Q      E+L+      E 
Sbjct: 822  AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEK-LEDLEVIQHRFES 880

Query: 1580 VKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD----RWLDINEKTE 1635
            ++ E N     V  +NQ+ + L             P EKE     D    RW    E  +
Sbjct: 881  LEPEMNNQASRVAVVNQIARQLMH--------SGHPSEKEIKAQQDKLNTRWSQFRELVD 932

Query: 1636 DYYENLGRALALWDKLFNLK-NVIDEWTEKALQKMELHQLTEEDRER----------LKE 1684
               + L  AL++ +  ++L+ N    W  +  + +E  Q    D             ++ 
Sbjct: 933  RKKDALLSALSIQN--YHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 990

Query: 1685 ELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALS 1744
            +L   E K S+  +   +++     SE P + Q + S +    +  ++  T   N  A  
Sbjct: 991  DLVAIEAKLSDLQKEAEKLE-----SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1045

Query: 1745 GSTAELRE---DLDQAKTQIGMTESLLKALSPSDSL----EIFTKLEEIQQQI------L 1791
            G  ++L++   DLD  ++ +  T++ + +    ++L    ++ T+ E I+ +I       
Sbjct: 1046 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY 1105

Query: 1792 QQKHSM-------------ILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
            Q+   M             + L  ++  L    +EL K +E+  +L +      Q H  +
Sbjct: 1106 QKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLS------QSHAYQ 1159

Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
                  K    + +N +  L    E   T +  E  ++K  DF+T    N +  ++++V+
Sbjct: 1160 QFLRDTKQAEAFLNNQEYVLAHT-EMPTTLEGAEAAIKKQEDFMTTMDANEE--KINAVV 1216

Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
            +  ++ +   ++          +   EK++SI     K  E + + L+RL+ D+R+L+K+
Sbjct: 1217 ETGRRLVSDGNINS--------DRIQEKVDSIDDRHRKNRETASELLMRLK-DNRDLQKF 1267

Query: 1959 LTNQEE------------------KWKGMEEPGEKTELFCQALARKREQFESVAQLNNSL 2000
            L + +E                  + + +     K + F   LA  +E  + + +    L
Sbjct: 1268 LQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQL 1327

Query: 2001 KEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
                  E E ++ E    + +   +L   ++ + +      + + F     D+  W+  +
Sbjct: 1328 ISEK-PETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGL 1386

Query: 2061 KE------------SLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE-SS 2107
            +             S+ +L   +  +  +  ++K KEI  L+ +  A  +      E  S
Sbjct: 1387 ESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRK-KEIEELQSQAQALSQEGKSTDEVDS 1445

Query: 2108 EAPLVQKTLTDISNQWDNTLH--LASTYLSH-----QEKLLLEGEKY-LQSKED----LR 2155
            +   VQ    ++    +   H  LAS  +       ++++L  GE+  L +  D    L+
Sbjct: 1446 KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1505

Query: 2156 LMLIELKKKQEAGFALQHGLQEKKAQL-KIYKKFLKKAQDLTSL--------LKELKSQG 2206
             + + +KK Q     LQ  +Q  + ++  I+++      D +SL        L +LK   
Sbjct: 1506 TVQLLIKKNQ----TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLW 1561

Query: 2207 NYLLECTKN----------------PSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVRE 2250
              L+E T+                  +   E W+  + L+    ++ +D  Q+    +++
Sbjct: 1562 GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE-QSAVSMLKK 1620

Query: 2251 HDSYQVCVTDLNTTLDNFSK-------------EFVSFSDKPVDQI------AVEEKLQK 2291
            H   +  V D   T+   SK             E +S     VD++        EE+  K
Sbjct: 1621 HQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGK 1680

Query: 2292 LQELEN--RLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA 2349
            L E     +L+ +   L++ +A  + V   +  +GQ    + +  LQ + ++      + 
Sbjct: 1681 LDERHRLFQLNREVDDLEQWIA-EREVVAGSHELGQDY--EHVTMLQERFREFARDTGNI 1737

Query: 2350 KQEMECCLNSILKSKRSTEKKGKFTLPGRE---KQATSDVQE----STQESAAVEKLEED 2402
             QE    +N +     ++      T+   +    +A +D+ E     TQ  AA  +L + 
Sbjct: 1738 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1797

Query: 2403 WEINKD----------SAVEMAMSKQLSLNAQESMKNTEDE------RKVNELQNQPLEL 2446
            +   K+             E     Q ++   + M  T +        +V +LQ     L
Sbjct: 1798 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1857

Query: 2447 DTMLRNEQLEEIEKLYTQ-LEAKKAAIKPLEQTEC-LNKTETGALVLHNIGYSAQHLDNL 2504
                  ++ ++I+K   + LEA K+ +   E     L  T         +      ++++
Sbjct: 1858 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1917

Query: 2505 LQALITLKKNKE--SQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIK- 2561
            ++ +   +K ++  S   ++ + Q   A +++   +  T  E  K          ++IK 
Sbjct: 1918 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1977

Query: 2562 KFIASIEKEKDSLGNLKIKWE----NLSNHVTDMDKKLLESQI---------KQLEHGWE 2608
            K +   EK K+ +   + +WE     L  H    D  + E+ +         +++    +
Sbjct: 1978 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2037

Query: 2609 QVEQQIQK--KYSQQVVEYDE-FTTL--MNKVQDTEISLQQQQQHLQLRLKSPE------ 2657
            +VE+ I++   + +    +DE F+ L  +  ++  E+  QQ+++  + R  SPE      
Sbjct: 2038 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2097

Query: 2658 ERAGNQSMIALTTDLQATKHGFSVLKGQAELQMK 2691
            E A +Q     +   Q +++G    +G   +  +
Sbjct: 2098 EEAESQQQWDTSKGEQVSQNGLPAEQGSPRVSYR 2131



 Score = 47.0 bits (110), Expect = 7e-04
 Identities = 124/633 (19%), Positives = 254/633 (40%), Gaps = 104/633 (16%)

Query: 3566 KLLQKVQKNKEL--VQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDH--PEK---- 3617
            K+L      K+L  V   + +  +F  E+      F+Q     ++M  ++H   EK    
Sbjct: 646  KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRER 705

Query: 3618 ----SEQFEELQ--SILKKGKLTFENIMEKLRIKYSE----MYTIVPAEIESQV------ 3661
                 EQ+  L+  S ++K +L   +++ + +    +    M  I+     S V      
Sbjct: 706  IIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYS 765

Query: 3662 -EECRKALEDIDEKISN-----EVLKSSPSYAMRRKIE--EINNGLHNVEKMLQQKSKNI 3713
             +   K  +D+ E+I+N     + L    S   +   E  ++   L  +E    ++ K +
Sbjct: 766  TQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIE----ERYKEV 821

Query: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIP--FQQYQQVSQ 3771
             +   ++K+   +    +   +E D+    I E++     +W++N+ IP   +  + +  
Sbjct: 822  AELTRLRKQALQDTLALYKMFSEADACELWIDEKE-----QWLNNMQIPEKLEDLEVIQH 876

Query: 3772 RAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSHHASTVQM 3829
            R E    ++N    ++   + + +     + ++ H       A  D L T       +  
Sbjct: 877  RFESLEPEMNNQASRVAVVNQIARQ----LMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 932

Query: 3830 ALEDSEQKHNLLHSIFMDL-EDLSIIFETDELTQSIQELSNQ---VTALQQKIMESLPQI 3885
              +D+      + +  ++  E  S I E  ++ +S Q+L N    V ALQ+K+       
Sbjct: 933  RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG----- 987

Query: 3886 QRMADDVVAIESEVKSMEKRVSKIKT-------ILLSK--EIFDFSPE--EHLKHGEVIL 3934
              M  D+VAIE+++  ++K   K+++        +LS+  EI D   E    LK+ E  L
Sbjct: 988  --MERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1045

Query: 3935 ENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVV 3994
                 +++ + ++  +Q  L   QT +    +    N L +  KLL   TQ +N     +
Sbjct: 1046 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLL---TQHEN-----I 1094

Query: 3995 IKQTNEWDEEIENLKQILNNYS-AQFSLEHMSPDQ-ADKLPQLQGEIERM---EKQILSL 4049
              + + ++E+ + ++ +    +  Q   ++M   Q    L     E+ +M    + +LS 
Sbjct: 1095 KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQ 1154

Query: 4050 NQRKEDLLVDLKATVLNL--------HQHLKQEQEGVERDRLPAVTSEEGGVAERDASER 4101
            +   +  L D K     L        H  +    EG E     A+  +E  +   DA+E 
Sbjct: 1155 SHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAE----AAIKKQEDFMTTMDANEE 1210

Query: 4102 KLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
            K+N     + +      V + ++ SD   EK +
Sbjct: 1211 KIN-----AVVETGRRLVSDGNINSDRIQEKVD 1238



 Score = 42.4 bits (98), Expect = 0.016
 Identities = 131/696 (18%), Positives = 255/696 (36%), Gaps = 143/696 (20%)

Query: 4661 NEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMW 4720
            ++I      + L   +    + +  E+++   + E E L      L +  K  D +DS  
Sbjct: 1388 SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKR 1447

Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMV---------ELVKIGKE-----KLAHGHLKQT 4766
              ++ ++ EL  P + E + + L    +         E++ +G+         HGH  QT
Sbjct: 1448 LTVQTKFMELLEP-LNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQT 1506

Query: 4767 -----KSKVALQAQIENHK-----VF--FQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
                 K    LQ +I+ H+     +F   Q +V D     + SA+ +   L + +  W  
Sbjct: 1507 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDS---SSLSAEAIRQRLADLKQLWGL 1563

Query: 4815 QVTEV----KILEEKSRQCGMKLQSL-LQKWEEFDENYASLE---KDLEILISTLPSVSL 4866
             + E     + LEE  R       +   + W    E Y   E   KD +  +S L    +
Sbjct: 1564 LIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQI 1623

Query: 4867 VEETEERLVERISFYQQIKRNIGG----KHARLYQTLNEGKQLVASVSCPELEGQIAKLE 4922
            +E+  E   E +    +  R +      +  R+    ++  +L A +     E +  KL+
Sbjct: 1624 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK-DLAEERRGKLD 1682

Query: 4923 EQW--LSLNKKID---------------HEL----HRLQALLKHLLSYNRDS-------- 4953
            E+     LN+++D               HEL      +  L +    + RD+        
Sbjct: 1683 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1742

Query: 4954 -------DQLTKWLESSQHTLNYWKEQSLNVSQDL----DTIRS------NINNFFEFSK 4996
                   D+L     S   T+  WK+       DL    DT          ++ F+  +K
Sbjct: 1743 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1802

Query: 4997 EV----------------DEKSSLKTA----------VISIGNQLLHLKETDTATLRASL 5030
            E+                 ++++++T           + ++G Q+  L+E D A L+A+ 
Sbjct: 1803 EIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE-DAARLQAAY 1861

Query: 5031 A------------QFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQ 5078
            A            +  + W  L+      + +L     +K      + +++ WM +V  Q
Sbjct: 1862 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG-DKFRFFSMVRDLMLWMEDVIRQ 1920

Query: 5079 TSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL---LQLSTCDVESKRY 5135
               ++    P   S V+ L+  H+  + E+D +       N S    ++L    +  K Y
Sbjct: 1921 IEAQEK---PRDVSSVELLMNNHQGIKAEIDAR-------NDSFTTCIELGKSLLARKHY 1970

Query: 5136 ERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKT 5195
               E  E L ++  +   +      + + L  +LE + +      +   WL  QE  L +
Sbjct: 1971 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEPYLSS 2029

Query: 5196 LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQ 5231
             +  +SV  V+KL+   +  E   A   +    L++
Sbjct: 2030 REIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2065



 Score = 42.0 bits (97), Expect = 0.021
 Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 10/209 (4%)

Query: 6539 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 6598
            + ++ H +L+     QQ   D +    W+  +E EL M+   K   +   + + +K+ Q 
Sbjct: 1567 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1623

Query: 6599 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 6656
            + +A + Y   V  ++ +S+  +    PES  +  R  ++  L+   +   +  RG L  
Sbjct: 1624 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1683

Query: 6657 RQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVER 6716
            R  L Q    ++   +L  W+A  +       +         L E  RE  +    +   
Sbjct: 1684 RHRLFQ---LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI--G 1738

Query: 6717 QPQVDMLQEISNSLLIKGHGEDCIEAEEK 6745
            Q +VD +  +++ L+  GH +    AE K
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWK 1767



 Score = 40.8 bits (94), Expect = 0.047
 Identities = 45/234 (19%), Positives = 104/234 (44%), Gaps = 22/234 (9%)

Query: 6504 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 6561
            KEG ++++  P+ E    A + E+ +G    WE++++  Q    +L      +      +
Sbjct: 1322 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1377

Query: 6562 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 6621
             +  WL   E++++     K   D+  + + +K+ Q +    +  K  +  +  S  + L
Sbjct: 1378 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQMLENQMEVRKKEIEELQ-SQAQAL 1433

Query: 6622 QTESPESTELQS-RLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNL---LLWL 6677
              E   + E+ S RL   +   E  +   +      + +L+  ++ HQ ++++   +LW+
Sbjct: 1434 SQEGKSTDEVDSKRLTVQTKFMELLEPLNER-----KHNLLASKEIHQFNRDVEDEILWV 1488

Query: 6678 ASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
                 R   A  TD   + + +    ++   L+KE+   QP++D + E S +++
Sbjct: 1489 GE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1539



 Score = 38.9 bits (89), Expect = 0.18
 Identities = 97/509 (19%), Positives = 202/509 (39%), Gaps = 38/509 (7%)

Query: 4643 KRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESR--VAKLRDEGERLH 4700
            + LY    +     Q +++ +    + EQ  +  A TV   +  SR  VA    E ER+ 
Sbjct: 1598 QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERIS 1657

Query: 4701 LPYALLQEVYK-LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVEL-VKIGKEKL 4758
            +  + + ++Y  L+D+ +   G L  R+      F    + D L Q + E  V  G  +L
Sbjct: 1658 MRQSKVDKLYAGLKDLAEERRGKLDERHRL----FQLNREVDDLEQWIAEREVVAGSHEL 1713

Query: 4759 AHGHLKQTKSKVALQ------AQIENHKVFFQKLVADMLLIQAYS-AKILPSLLQNRETF 4811
               +   T  +   +        I   +V     +AD L+   +S A  +          
Sbjct: 1714 GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEA 1773

Query: 4812 WAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETE 4871
            WA+ +   ++++ +++      + L + + +  E +  ++   + L   L       ET 
Sbjct: 1774 WADLL---ELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETL 1829

Query: 4872 ERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKK 4931
            +R+    +F   I+  +G +  +L +     +   A     +++ +  ++ E W SL   
Sbjct: 1830 QRM--HTTFEHDIQA-LGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDA 1886

Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNF 4991
             +    RL         ++   D L  W+E     +     ++    +D+ ++   +NN 
Sbjct: 1887 CESRRVRLVDTGDKFRFFSMVRD-LMLWMEDVIRQI-----EAQEKPRDVSSVELLMNNH 1940

Query: 4992 FEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
                 E+D ++   T  I +G  LL  K   +  ++  L Q  +K   +I +  D  E L
Sbjct: 1941 QGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWL 2000

Query: 5052 HQ-LQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDY 5110
               L++ +     ++ E  +W+   E   S  +      S  +V+ L+++H+ F  E   
Sbjct: 2001 RLILEVHQFSRDASVAE--AWLLGQEPYLSSRE---IGQSVDEVEKLIKRHEAF--EKSA 2053

Query: 5111 KQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
              W   F   +L +L+T ++   R ++ E
Sbjct: 2054 ATWDERF--SALERLTTLELLEVRRQQEE 2080



 Score = 33.1 bits (74), Expect = 9.8
 Identities = 58/281 (20%), Positives = 116/281 (41%), Gaps = 25/281 (8%)

Query: 6500 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 6557
            +D  KE  ++ + +P Q    L+ + E      D WE ++    + +  + +   LQQ  
Sbjct: 1000 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1055

Query: 6558 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 6617
             D+    +WL +T+  +    M   P+ + E E  + + + I    D Y+     +    
Sbjct: 1056 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1112

Query: 6618 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLM-QCQDFHQLSQNLLL 6675
            +   Q ++  +   L+ RL+ L   W         W    RQ+L+ Q   + Q  ++   
Sbjct: 1113 EMVTQGQTDAQYMFLRQRLQALDTGWNELH---KMWEN--RQNLLSQSHAYQQFLRDTKQ 1167

Query: 6676 WLASAKNRRQ-KAHVTDPKA--DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 6732
              A   N+    AH   P       A ++ + + M     +   + +++ + E    L+ 
Sbjct: 1168 AEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFM---TTMDANEEKINAVVETGRRLVS 1224

Query: 6733 KGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 6772
             G+   D I  +EKV  I+ + ++ RE  S+ LM L+  ++
Sbjct: 1225 DGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1263


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
           sapiens]
          Length = 2364

 Score =  200 bits (508), Expect = 5e-50
 Identities = 144/455 (31%), Positives = 225/455 (49%), Gaps = 80/455 (17%)

Query: 24  SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD- 82
           +L  E+E  QKK FT W+NS LAR +    I+DL+TD++ G +L+ LLEVLSG++LP+  
Sbjct: 47  ALADEREAVQKKTFTKWVNSHLARVSCR--ITDLYTDLRDGRMLIKLLEVLSGERLPKPT 104

Query: 83  KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
           KG     C  N++ AL FL+ + + L N+   DI+DGN  + LGLIWTIIL F I+ ++ 
Sbjct: 105 KGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISV 164

Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
               N                              + + SA+ ALLLW Q + A Y +VN
Sbjct: 165 ETEDN------------------------------KEKKSAKDALLLWCQMKTAGYPNVN 194

Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
           + +F +SWR+GMAF A+IH  RPDLID   +K  +   NL+ AF +AEQ L + +LL+PE
Sbjct: 195 IHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPE 254

Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDS-E 321
           D+ V  PDEKSI+TYV  +  Y                  M  L ++ +++ K+L ++ E
Sbjct: 255 DISVDHPDEKSIITYVVTYYHYF---------------SKMKALAVEGKRIGKVLDNAIE 299

Query: 322 NDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAWDGLDHQINAWK 381
            +   +KY SL S +  + E+    L              ++ +   +  G+  Q+ A+ 
Sbjct: 300 TEKMIEKYESLASDLLEWIEQTIIIL--------------NNRKFANSLVGVQQQLQAFN 345

Query: 382 IKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFK-----SLMDR 436
                  PP   +       +E L+    S  + ++Q V + +E   +         +++
Sbjct: 346 TYRTVEKPPKFTEK----GNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEK 401

Query: 437 FEHHSNILLTFENKDENHLPLVPPNKLEEMKRRIN 471
            EH   + L  E        L+   KLE++ RR +
Sbjct: 402 AEHERELALRNE--------LIRQEKLEQLARRFD 428



 Score = 99.0 bits (245), Expect = 1e-19
 Identities = 303/1650 (18%), Positives = 640/1650 (38%), Gaps = 218/1650 (13%)

Query: 4817 TEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLE-------ILISTLPSVSLVEE 4869
            +++K L  + ++ G  L + ++  E+  E Y SL  DL        I+++     + +  
Sbjct: 278  SKMKALAVEGKRIGKVLDNAIET-EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 336

Query: 4870 TEERLVERISFYQQIKR-----NIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQ 4924
             +++L +  + Y+ +++       G     L+   ++ +     V  P     I+ + + 
Sbjct: 337  VQQQL-QAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKA 395

Query: 4925 WLSLNKK-------IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNV 4977
            W  L K        + +EL R + L +    ++R +     WL  +Q  ++       N 
Sbjct: 396  WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS-----QDNF 450

Query: 4978 SQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
              DL  + +          ++        AV+++  +L      D   + A      + W
Sbjct: 451  GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLW 510

Query: 5038 TMLITQLPDIQEKLHQLQMEKLPSRKAITEMI---SWMNNVEHQTSDEDSVHSPSSASQV 5094
              L+  L   +++L       L  +K   EM+    WM+ ++     +D          V
Sbjct: 511  EYLLELLRARRQRLEM----NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY---GKHLLGV 563

Query: 5095 KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRV 5154
            + LLQKH     ++  +   V  VN S  + +T     K  +     + +  M   +  +
Sbjct: 564  EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 623

Query: 5155 HGMLNRKIQHLEQ---LLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD 5211
              +   +   LE+   L +   E   +      W+  +E+ L +    + + SV +LL  
Sbjct: 624  CQLAAERRARLEESRRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLLSK 679

Query: 5212 CQDIENQLAIKS----KALDELKQSYLTLESGAVPLLE------------DTASRIDELF 5255
             +  E++++ +S    +A+ E +        G+  + E            +  S I +  
Sbjct: 680  HRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKR 739

Query: 5256 QKRSSVLTQ----VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
             + +S+L Q     + +   M  +L+     D  +DE +  ++     ++  K V   + 
Sbjct: 740  LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSL-----VKKHKDVAEEIA 794

Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQ 5371
              R     L +L ++A +      +  +V G+L G+                +R+ +V +
Sbjct: 795  NYR---PTLDTLHEQASALPQEHAESPDVRGRLSGI---------------EERYKEVAE 836

Query: 5372 AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQD 5431
                + Q  Q  L L+K +S A    A  L   E K Q L N+          +P  L+D
Sbjct: 837  LTRLRKQALQDTLALYKMFSEAD---ACELWIDE-KEQWLNNMQ---------IPEKLED 883

Query: 5432 IKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANE 5491
            ++ +QH  +  +      +S +  + Q A    H   P    S +     +  L  + ++
Sbjct: 884  LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP----SEKEIKAQQDKLNTRWSQ 939

Query: 5492 FEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEK-----ENPDSFLNHVLALTAQSP 5546
            F  ++ + KD  +   S++   +   E    + ++ K     ++  + L  V+AL  +  
Sbjct: 940  FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 999

Query: 5547 DIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWI 5606
             +E  + V+++  LSD+  K  + +  +        L R +E+  +          E+  
Sbjct: 1000 GMER-DLVAIEAKLSDLQ-KEAEKLESEHPDQAQAILSRLAEISDVW---------EEMK 1048

Query: 5607 QLLEKIEEALKVDVANSLPELLEQQKTYK--MLEAEVSINQTIADSYVTQSLQLLDT--- 5661
              L+  E +L    A+ L + L     ++  +   + +I      + +T++ +LL     
Sbjct: 1049 TTLKNREASL--GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN 1106

Query: 5662 --TEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT 5719
               EI+N  E   ++ K+ D  +   QG  Q       L ++ Q   T    L +   + 
Sbjct: 1107 IKNEIDNYEE---DYQKMRDMGEMVTQG--QTDAQYMFLRQRLQALDTGWNELHKMWENR 1161

Query: 5720 SHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTD--LKTK 5777
             +LLS     ++F L  T+     L N+E  +    T    TLE  E  +   +  + T 
Sbjct: 1162 QNLLSQSHAYQQF-LRDTKQAEAFLNNQE--YVLAHTEMPTTLEGAEAAIKKQEDFMTTM 1218

Query: 5778 ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPL 5837
            ++   +I+ + ++ + +         + Q  V++ D   +K +E  S L +++ +    L
Sbjct: 1219 DANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASEL-LMRLKDNRDL 1277

Query: 5838 PELHEDLH------NEKELIK------ELEQSLASWTQN---LKELQTMKADLTR----- 5877
             +  +D        NEK L        E     + W ++   + EL + K  L +     
Sbjct: 1278 QKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG 1337

Query: 5878 ----HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWL 5933
                    E   V+KE++  LH+ WE L      + Q + D  N   +F +   +L  WL
Sbjct: 1338 MQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWL 1396

Query: 5934 VQMENKVLQTADIS--IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA- 5990
              +E+++ Q+ D    +  +   L+K  M E N     K +++++  Q    S + ++  
Sbjct: 1397 HGLESQI-QSDDYGKDLTSVNILLKKQQMLE-NQMEVRKKEIEELQSQAQALSQEGKSTD 1454

Query: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA-RIESELSKPV 6049
            E+D K   +  ++  L + +  R   L  +   I Q ++++ +   W+  R+    S   
Sbjct: 1455 EVDSKRLTVQTKFMELLEPLNERKHNLLASKE-IHQFNRDVEDEILWVGERMPLATSTDH 1513

Query: 6050 VYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQT 6109
             +++   Q +Q  + + Q LQ++I+ H   ++ +F     ++ DS + + E    +I+Q 
Sbjct: 1514 GHNL---QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE----AIRQR 1566

Query: 6110 TRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLY 6169
               L + W  +   + +R  ++EE  R  Q++  D +  E W+   E        ++   
Sbjct: 1567 LADLKQLWGLLIEETEKRHRRLEEAHRA-QQYYFDAAEAEAWMSEQELYMMSEEKAKD-E 1624

Query: 6170 TSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTA-------------SRLK 6216
             SA   LK+ +  ++ + +    +  ++K  R L  ++  ++              + LK
Sbjct: 1625 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK 1684

Query: 6217 QMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE 6276
             +  E   + D   R     L +L    +  E++   RE ++    E+     +V    E
Sbjct: 1685 DLAEERRGKLDERHR-----LFQLNREVDDLEQWIAERE-VVAGSHELGQDYEHVTMLQE 1738

Query: 6277 SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQ------------------LIQKSEPLD 6318
               +      N  Q+ +    +  D+LI  G                    L++  +   
Sbjct: 1739 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1798

Query: 6319 AVLIED-ELEELHRYCQEVFGRVSRFHRRL 6347
             +L    EL + +   +E+FGR+   H++L
Sbjct: 1799 QILAASYELHKFYHDAKEIFGRIQDKHKKL 1828



 Score = 83.6 bits (205), Expect = 6e-15
 Identities = 226/1304 (17%), Positives = 502/1304 (38%), Gaps = 152/1304 (11%)

Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
            +K +ER E AEH  E+          L  ++   E+L +     + K  +   WL   + 
Sbjct: 393  NKAWERLEKAEHEREL---------ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443

Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG------AVPLLE 5245
             +        + +V+      + IE  +A   + +  +      LE+        +   +
Sbjct: 444  LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 503

Query: 5246 DTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKP 5305
            D   R+ E   +      Q  ++   +Q + QE        DE+ ++ +      ++ K 
Sbjct: 504  DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLS----QDYGKH 559

Query: 5306 VVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKR 5365
            ++   + L+        +  +AE   G     Q+     +G  P   ++I ++  +    
Sbjct: 560  LLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFC 619

Query: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
            + ++ Q  A++  + +   +LWK +     E    ++++E    ++ +    G +L  ++
Sbjct: 620  YQELCQLAAERRARLEESRRLWKFFWEM-AEEEGWIREKE----KILSSDDYGKDLTSVM 674

Query: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKML 5485
               L   +  + ++      F Q     + +       +  +    ++  ++ A LE++ 
Sbjct: 675  R-LLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLS 733

Query: 5486 LVKANEFE--FVLSQFK----DFGVRLESLKGLIM-----HEEENLDRLHQQEKENPDSF 5534
             ++    E   +L QF+    D    +  +  ++      H+E +   L ++ K+  +  
Sbjct: 734  AIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEI 793

Query: 5535 LNH-----VLALTAQSPDIEHLNEVSLKLPLSDVA-----VKTLQNMNRQWIRATATALE 5584
             N+      L   A +   EH     ++  LS +      V  L  + +Q ++ T    +
Sbjct: 794  ANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYK 853

Query: 5585 RCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSIN 5644
              SE             CE WI   EK +    + +   L +L   Q  ++ LE E++ N
Sbjct: 854  MFSEADA----------CELWID--EKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMN-N 900

Query: 5645 QTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQD 5704
            Q    + V Q  + L  +   +  E   +  KL  RW    + V ++K   D L+     
Sbjct: 901  QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKK---DALLS---- 953

Query: 5705 FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEA 5764
               S++N      +T   +     ++   +  T+ L ++L    +  QR+ T     L A
Sbjct: 954  -ALSIQNYHLECNETKSWIR----EKTKVIESTQDLGNDLAGV-MALQRKLTGMERDLVA 1007

Query: 5765 GEKLLLTTDLKTK------------ESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETW 5812
             E  L  +DL+ +            +++  R++++ D W++M+  L    K  ++++   
Sbjct: 1008 IEAKL--SDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTL----KNREASLGEA 1061

Query: 5813 DQCEKKIKELK------SRLQVLKAQSEDP--------LPELHEDLHNEKELIKELEQSL 5858
             + ++ +++L       SR Q   A  + P        L   HE++ NE +  +E  Q +
Sbjct: 1062 SKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM 1121

Query: 5859 ASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNT 5918
                + + + QT   D     L + +  L      LH+ WE+        +Q +  + + 
Sbjct: 1122 RDMGEMVTQGQT---DAQYMFLRQRLQALDTGWNELHKMWEN--------RQNLLSQSHA 1170

Query: 5919 WVVFNEKNKELCAWLVQMENKVLQTADISIEEMIE---KLQKDCMEEINLFSENKLQLKQ 5975
            +  F    K+  A+L   E  +  T   +  E  E   K Q+D M  ++   E    + +
Sbjct: 1171 YQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVE 1230

Query: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035
             G +L+   N + +  I +K++ I+DR +   +     + +LK+    +Q+  ++   L 
Sbjct: 1231 TGRRLVSDGNIN-SDRIQEKVDSIDDRHRKNRETASELLMRLKDN-RDLQKFLQDCQELS 1288

Query: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095
             W+   +   ++ + YD  + + +  +  + Q    ++  +   ++ +      L+ +  
Sbjct: 1289 LWINE-KMLTAQDMSYD--EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKP 1345

Query: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155
                ETE   +++    L + W  + + +  +  ++ +  +  + F    +  + WL   
Sbjct: 1346 ----ETEA-VVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGL 1399

Query: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLAREN-------- 6207
            E      +  + L TS    LK+ +  + Q+  R  ++E +  Q + L++E         
Sbjct: 1400 ESQIQSDDYGKDL-TSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1458

Query: 6208 -RTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDL 6266
             R    ++  +++   N+R  NL              + +  +F    E  ++W+ E   
Sbjct: 1459 KRLTVQTKFMELLEPLNERKHNLLA------------SKEIHQFNRDVEDEILWVGERMP 1506

Query: 6267 QLTNVEHFSESDADDKMRQLNG-FQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDE 6325
              T+ +H         + + N   Q+EI  +  +ID +    + ++  S  L A  I   
Sbjct: 1507 LATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQR 1566

Query: 6326 LEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED 6369
            L +L +    +     + HRRL       +   +A+E E  M +
Sbjct: 1567 LADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1610



 Score = 78.2 bits (191), Expect = 3e-13
 Identities = 173/872 (19%), Positives = 347/872 (39%), Gaps = 156/872 (17%)

Query: 4657 QQSLNEISGQSVAEQLQ----KADAYTVELENAESRVAKLRDEGERL-HLPYALLQEVYK 4711
            +Q LN +      E L+    + ++   E+ N  SRVA +     +L H  +   +E+  
Sbjct: 869  EQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 928

Query: 4712 LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMV----------------ELVKI-- 4753
             +D L++ W   R          + + ++DALL  +                 E  K+  
Sbjct: 929  QQDKLNTRWSQFRE---------LVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 979

Query: 4754 ----------GKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPS 4803
                      G   L        +  VA++A++ + +   +KL ++        A+ + S
Sbjct: 980  STQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE----HPDQAQAILS 1035

Query: 4804 LLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPS 4863
             L      W E  T +K  E    +   KLQ  L+  ++F     S     +  I++   
Sbjct: 1036 RLAEISDVWEEMKTTLKNREASLGEAS-KLQQFLRDLDDFQ----SWLSRTQTAIASEDM 1090

Query: 4864 VSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEE 4923
             + + E E+ L +    ++ IK  I   +   YQ + +  ++V        +GQ    + 
Sbjct: 1091 PNTLTEAEKLLTQ----HENIKNEIDN-YEEDYQKMRDMGEMVT-------QGQT---DA 1135

Query: 4924 QWLSLNKKID------HELHRLQALLKHLLSYN-------RDSDQLTKWLESSQHTLNYW 4970
            Q++ L +++       +ELH++    ++LLS +       RD+ Q   +L + ++ L + 
Sbjct: 1136 QYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHT 1195

Query: 4971 KEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASL 5030
            +     +   L+   + I    +F   +D       AV+  G +L+     ++  ++  +
Sbjct: 1196 E-----MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250

Query: 5031 AQFEQKWT----------MLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080
               + +            M +    D+Q+ L   Q           E+  W+N  E   +
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-----------ELSLWIN--EKMLT 1297

Query: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEM-DYKQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
             +D  +  +     K L  KH+ F  E+   K+W+ D + +  +QL    +  K      
Sbjct: 1298 AQDMSYDEARNLHSKWL--KHQAFMAELASNKEWL-DKIEKEGMQL----ISEKPETEAV 1350

Query: 5140 FAEHLGEMNRQWHRVHGMLNRKIQHL--EQLLESITESENKIQILNNWLEAQEERLKTLQ 5197
              E L  +++ W  +      K Q L      E  T+S      L+ WL   E ++++  
Sbjct: 1351 VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQS---CADLDKWLHGLESQIQSDD 1407

Query: 5198 KPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
              + + SV  LL   Q +ENQ+ ++ K ++EL+             L       DE+  K
Sbjct: 1408 YGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ--------AQALSQEGKSTDEVDSK 1459

Query: 5258 RSSVLTQ-------VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSL 5310
            R +V T+       +N+ K ++ +  +  +    + DE+  +  R    +  S     +L
Sbjct: 1460 RLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERM--PLATSTDHGHNL 1517

Query: 5311 ETLRCQVENLQSLQDEAESS----EGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
            +T++  ++  Q+LQ E +      +  +E+ Q ++     L    AE I ++  +  + W
Sbjct: 1518 QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS---AEAIRQRLADLKQLW 1574

Query: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQE--------AKFQQLANISMSG 5418
              + +    + ++ +   +  + Y +A  EA A + +QE        AK +Q A +SM  
Sbjct: 1575 GLLIEETEKRHRRLEEAHRAQQYYFDA-AEAEAWMSEQELYMMSEEKAKDEQSA-VSMLK 1632

Query: 5419 NNLAEILPPALQDIKELQHDVQKTKEAFLQNS 5450
             +  +IL  A++D  E  H + KT  A + +S
Sbjct: 1633 KH--QILEQAVEDYAETVHQLSKTSRALVADS 1662



 Score = 77.8 bits (190), Expect = 3e-13
 Identities = 166/927 (17%), Positives = 359/927 (38%), Gaps = 102/927 (11%)

Query: 5883 DVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQ 5942
            D  V+++++ H+   +++LC   A R+  +E+    W  F E  +E   W+ + E K+L 
Sbjct: 605  DPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEE-GWIREKE-KILS 662

Query: 5943 TADI-----SIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLN 5997
            + D      S+  ++ K  +   +E++  S +  Q  + G+ +I A     + +I +++ 
Sbjct: 663  SDDYGKDLTSVMRLLSK-HRAFEDEMSGRSGHFEQAIKEGEDMI-AEEHFGSEKIRERII 720

Query: 5998 KINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQ 6057
             I ++W +L  +   R K+L+E  + + Q   +  ++  W+  I   +S   V    D+ 
Sbjct: 721  YIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSDVGH--DEY 777

Query: 6058 EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRW 6117
              Q  + + +D+  +I  +   ++++      L  +        E   ++     ++ R+
Sbjct: 778  STQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE------HAESPDVRGRLSGIEERY 831

Query: 6118 RNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELK 6177
            + +  ++  R+  +++T  L++ F  +    E W+   E+        E L     E+L+
Sbjct: 832  KEVAELTRLRKQALQDTLALYKMF-SEADACELWIDEKEQWLNNMQIPEKL-----EDLE 885

Query: 6178 ----RFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQ--- 6230
                RFE+ + +++ + +++ ++N+  R+L       +   +K    + N RW   +   
Sbjct: 886  VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP-SEKEIKAQQDKLNTRWSQFRELV 944

Query: 6231 -RRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDK--MRQLN 6287
             R+  A+L  L    N   E   T+     W+ E    + + +      A      R+L 
Sbjct: 945  DRKKDALLSALS-IQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLT 999

Query: 6288 GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
            G ++++     K+  L    E+L +   P  A  I   L E+    +E+   +      L
Sbjct: 1000 GMERDLVAIEAKLSDLQKEAEKL-ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1058

Query: 6348 TSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHER 6403
                       EAS+ +  + D  + Q  SW  R +    SE+  +  +    +   HE 
Sbjct: 1059 G----------EASKLQQFLRDLDDFQ--SWLSRTQTAIASEDMPNTLTEAEKLLTQHEN 1106

Query: 6404 SGCETPVSVDSIPLEWDHTGDVGGSSSHEEDEEGPYYSALSGKSISDGHS-----WHVPD 6458
               E    +D+   ++    D+G   +  + +    +     +++  G +     W    
Sbjct: 1107 IKNE----IDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQ 1162

Query: 6459 SPSCPEHHYKQMEGDRN-----------------VPPVPPASSTPYKPPYGKLLLPPGTD 6501
            +     H Y+Q   D                   +P     +    K     +      +
Sbjct: 1163 NLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANE 1222

Query: 6502 GGKEGPRVLNGNPQQEDGGLAG--ITEQQSGAFDRWEMIQ--AQELHNKLKIKQNLQQLN 6557
              K    V  G     DG +    I E+     DR    +  A EL  +LK  ++LQ+  
Sbjct: 1223 E-KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFL 1281

Query: 6558 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--QEILKAFDTYKALVVSVNV 6615
             D   ++ W+       E +  A+  S  +   L  K L  Q  +    + K  +  +  
Sbjct: 1282 QDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1335

Query: 6616 SSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLL 6675
               + +  +      ++ +L  L  +WE  +    +    L  +  + + F Q   +L  
Sbjct: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDK 1394

Query: 6676 WLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 6735
            WL   +++ Q             LL   ++   LE ++  R+ +++ LQ  + +L  +G 
Sbjct: 1395 WLHGLESQIQSDDYGKDLTSVNILL---KKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1451

Query: 6736 GEDCIEAEEKVHVIEKKLKQLREQVSQ 6762
              D  E + K   ++ K  +L E +++
Sbjct: 1452 STD--EVDSKRLTVQTKFMELLEPLNE 1476



 Score = 77.8 bits (190), Expect = 3e-13
 Identities = 265/1440 (18%), Positives = 537/1440 (37%), Gaps = 197/1440 (13%)

Query: 4959 WLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL 5018
            W+   +  L+     S +  +DL ++   ++    F  E+  +S      I  G  ++  
Sbjct: 653  WIREKEKILS-----SDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE 707

Query: 5019 KETDTATLRASLAQFEQKWTMLITQLPDIQEK-------LHQLQMEKLPSRKAITEMISW 5071
            +   +  +R  +    ++W  L  QL  I++K       LHQ Q +         ++ +W
Sbjct: 708  EHFGSEKIRERIIYIREQWANL-EQLSAIRKKRLEEASLLHQFQADA-------DDIDAW 759

Query: 5072 MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE 5131
            M ++    S  D  H   S      L++KHK+   E+   +  +D +++    L     E
Sbjct: 760  MLDILKIVSSSDVGHDEYSTQS---LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE 816

Query: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191
            S      +    L  +  ++  V  +   + Q L+  L ++ +  ++      W++ +E+
Sbjct: 817  SP-----DVRGRLSGIEERYKEVAELTRLRKQALQDTL-ALYKMFSEADACELWIDEKEQ 870

Query: 5192 RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRI 5251
             L  +Q PE +  ++ +    + +E ++  ++  +  + Q    L     P  ++  ++ 
Sbjct: 871  WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 930

Query: 5252 DELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLE 5311
            D+L  + S     V++ K ++ S L   + Y    +E           +E ++ +   L 
Sbjct: 931  DKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLA 989

Query: 5312 TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQV-- 5369
             +      L  ++ +  + E     LQ+   KL+   P  A+ I  +       W ++  
Sbjct: 990  GVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKT 1049

Query: 5370 ----NQAIADQLQKAQSLL------QLWKAYS----------NAHGEAAARLKQQE---- 5405
                 +A   +  K Q  L      Q W + +          N   EA   L Q E    
Sbjct: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109

Query: 5406 ---------AKFQQLANISMSGNNLAE--ILPPALQDI----KELQHDVQKTKEAFLQNS 5450
                      K + +  +   G   A+   L   LQ +     EL H + + ++  L  S
Sbjct: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWENRQNLLSQS 1168

Query: 5451 SVLDRLPQPAESS-----------THMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
                +  +  + +            H  +P  L   + A   ++  +   +  E  ++  
Sbjct: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAV 1228

Query: 5500 KDFGVRLESLKGL----IMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS 5555
             + G RL S   +    I  + +++D  H++ +E     L  +         ++   E+S
Sbjct: 1229 VETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELS 1288

Query: 5556 L-----KLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLE 5610
            L      L   D++    +N++ +W++  A   E  S               ++W+  +E
Sbjct: 1289 LWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASN--------------KEWLDKIE 1334

Query: 5611 KIEEALKVDVANSLPELLEQQK---TYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENR 5667
            K  E +++       E + ++K    +KM E   S  QT A        +L D     N+
Sbjct: 1335 K--EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ-------RLFDA----NK 1381

Query: 5668 PEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
             E  T+     D+W + ++   Q + D  G     +D  TSV  L +      + +   K
Sbjct: 1382 AELFTQSCADLDKWLHGLES--QIQSDDYG-----KDL-TSVNILLKKQQMLENQMEVRK 1433

Query: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQL 5787
             +      Q ++L  E K+ +    +R T     +E  E L    + K      + I Q 
Sbjct: 1434 KEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL---NERKHNLLASKEIHQF 1490

Query: 5788 QDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNE 5847
                +D    + E +    ST    +   + ++ L  + Q L+ + +   P + +     
Sbjct: 1491 NRDVEDEILWVGERMPLATSTDHGHNL--QTVQLLIKKNQTLQKEIQGHQPRIDDIFERS 1548

Query: 5848 KELIKELEQ-SLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
            + ++ +    S  +  Q L +L+ +              +L E+ E  HR+ E+     A
Sbjct: 1549 QNIVTDSSSLSAEAIRQRLADLKQLWG------------LLIEETEKRHRRLEE-----A 1591

Query: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEE-MIEKLQKDCMEE--I 5963
             R Q+          F+    E  AW+ + E  ++       E+  +  L+K  + E  +
Sbjct: 1592 HRAQQ--------YYFDAAEAE--AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAV 1641

Query: 5964 NLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAF 6023
              ++E   QL +    L+ A +   +  I  + +K++  +  L D+   R  KL E    
Sbjct: 1642 EDYAETVHQLSKTSRALV-ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1700

Query: 6024 IQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQ-QDLQRDIEQHSAGVES 6082
              QL++ + +L  W+A  E        +++  D E    L E+ ++  RD    + G E 
Sbjct: 1701 F-QLNREVDDLEQWIAEREVVAGS---HELGQDYEHVTMLQERFREFARD--TGNIGQER 1754

Query: 6083 VFNICDVLLHDSDACANETECD--SIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQK 6140
            V    D + H +D   N    D  +I +    L+  W ++  +   R   +  ++ L  K
Sbjct: 1755 V----DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL-HK 1809

Query: 6141 FLDD----YSRFED-WLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLEL 6195
            F  D    + R +D   K  E      N+ E L        +    F+  I    TQ+  
Sbjct: 1810 FYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ-------RMHTTFEHDIQALGTQVRQ 1862

Query: 6196 INKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHF-TNQREEFEGTR 6254
            + +   RL      D A  +++  +E  + W +L     +  RR+R   T  +  F    
Sbjct: 1863 LQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACES--RRVRLVDTGDKFRFFSMV 1920

Query: 6255 ESILVWLTEMDLQLTNVEHFSE-SDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
              +++W+ ++  Q+   E   + S  +  M    G + EI    +     I  G+ L+ +
Sbjct: 1921 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980



 Score = 48.9 bits (115), Expect = 2e-04
 Identities = 177/879 (20%), Positives = 349/879 (39%), Gaps = 166/879 (18%)

Query: 2949 HEKTSAL-QEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDY 3007
            HE+ SAL QE A+S      L       G+ EE Y     LT ++   LQ        D 
Sbjct: 804  HEQASALPQEHAESPDVRGRL------SGI-EERYKEVAELTRLRKQALQ--------DT 848

Query: 3008 IGLNWDFSQLDQLQTQVFEKEK-----ELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQI 3062
            + L   FS+ D  +  + EKE+     ++ EK++ L+  +    ++++L  +M     ++
Sbjct: 849  LALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQH---RFESLEPEMNNQASRV 905

Query: 3063 KKMTEVVLKAPDSS-PESRRLNAQI--LSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKE 3119
              + ++  +   S  P  + + AQ   L+ R  + + L D   KK              E
Sbjct: 906  AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR--KKDALLSALSIQNYHLE 963

Query: 3120 ILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLIN 3179
              + K    E  K+ +  Q++  +L+     ++     +E  L  +    S LQ+     
Sbjct: 964  CNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG-MERDLVAIEAKLSDLQKEAE-K 1021

Query: 3180 LEIKHIQNEKDNCEAFQE--QVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQ 3237
            LE +H    +       E   VW EM +        K RE +  EAS ++  LR+ +D Q
Sbjct: 1022 LESEHPDQAQAILSRLAEISDVWEEMKTTL------KNREASLGEASKLQQFLRDLDDFQ 1075

Query: 3238 MQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPL 3297
              L+ +   +T + ++   N       +T A + +T  E I    + ++ N EE  +  +
Sbjct: 1076 SWLSRT---QTAIASEDMPN------TLTEAEKLLTQHENI----KNEIDNYEEDYQ-KM 1121

Query: 3298 RKQEELES---TVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEA 3354
            R   E+ +   T A    L ++L  + +   +L   +  ++ +   S   + F     +A
Sbjct: 1122 RDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQA 1181

Query: 3355 ERYLENYKCYRKMEEDIYTNLSKMETVLGQS---MSSLPLSYREALERLEQSKALVS--- 3408
            E +L N + Y     ++ T L   E  + +    M+++  +  +    +E  + LVS   
Sbjct: 1182 EAFLNNQE-YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN 1240

Query: 3409 -------------------NLISTKEELMKLR--QILRLLRLRCTENDGICLLKIVSA-- 3445
                               N  +  E LM+L+  + L+     C E       K+++A  
Sbjct: 1241 INSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQD 1300

Query: 3446 --------LWEKWLS----LLEAAKEWEMWCEELKQE-WKFVSEEIEREAII------LD 3486
                    L  KWL     + E A   E W +++++E  + +SE+ E EA++      L 
Sbjct: 1301 MSYDEARNLHSKWLKHQAFMAELASNKE-WLDKIEKEGMQLISEKPETEAVVKEKLTGLH 1359

Query: 3487 NLQEELPEISKTK-EAATTEELSELLDCLC-----------------QYGEN-------V 3521
             + E L   ++TK +       +EL    C                  YG++       +
Sbjct: 1360 KMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL 1419

Query: 3522 EKQQLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTE 3581
            +KQQ+L   +  R + I+ +   + A+      QE  S  E  +K L    K  EL++  
Sbjct: 1420 KKQQMLENQMEVRKKEIEELQSQAQALS-----QEGKSTDEVDSKRLTVQTKFMELLEPL 1474

Query: 3582 IQERHSF--TKEIIAL-KNFFQQTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENI 3638
             + +H+   +KEI    ++   +     + M      +     + +Q ++KK +      
Sbjct: 1475 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQ------ 1528

Query: 3639 MEKLRIKYSEMYTIVPAEIESQVEECRKALEDIDEKISNEVLKSS--PSYAMRRKIEEIN 3696
                              ++ +++  +  ++DI E+  N V  SS   + A+R+++ ++ 
Sbjct: 1529 -----------------TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLK 1571

Query: 3697 NGLHNVEKMLQQKSKNIEKAQEIQKKMWD--ELDLWHSK 3733
                 + +  +++ + +E+A   Q+  +D  E + W S+
Sbjct: 1572 QLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE 1610



 Score = 47.4 bits (111), Expect = 5e-04
 Identities = 253/1411 (17%), Positives = 539/1411 (38%), Gaps = 231/1411 (16%)

Query: 1464 KHRKKSLIRLDKVLDE----YEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENT 1519
            ++  +SL++  K + E    Y      L E A++LP  +      V  +       ++  
Sbjct: 776  EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRLSGIEERYKEV 834

Query: 1520 KALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEI 1579
              L     +     L L K +    +    + +KE+ + ++Q      E+L+      E 
Sbjct: 835  AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEK-LEDLEVIQHRFES 893

Query: 1580 VKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVD----RWLDINEKTE 1635
            ++ E N     V  +NQ+ + L             P EKE     D    RW    E  +
Sbjct: 894  LEPEMNNQASRVAVVNQIARQLMH--------SGHPSEKEIKAQQDKLNTRWSQFRELVD 945

Query: 1636 DYYENLGRALALWDKLFNLK-NVIDEWTEKALQKMELHQLTEEDRER----------LKE 1684
               + L  AL++ +  ++L+ N    W  +  + +E  Q    D             ++ 
Sbjct: 946  RKKDALLSALSIQN--YHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 1003

Query: 1685 ELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALS 1744
            +L   E K S+  +   +++     SE P + Q + S +    +  ++  T   N  A  
Sbjct: 1004 DLVAIEAKLSDLQKEAEKLE-----SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1058

Query: 1745 GSTAELRE---DLDQAKTQIGMTESLLKALSPSDSL----EIFTKLEEIQQQI------L 1791
            G  ++L++   DLD  ++ +  T++ + +    ++L    ++ T+ E I+ +I       
Sbjct: 1059 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDY 1118

Query: 1792 QQKHSM-------------ILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSK 1838
            Q+   M             + L  ++  L    +EL K +E+  +L +      Q H  +
Sbjct: 1119 QKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLS------QSHAYQ 1172

Query: 1839 LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVL 1898
                  K    + +N +  L    E   T +  E  ++K  DF+T    N +  ++++V+
Sbjct: 1173 QFLRDTKQAEAFLNNQEYVLAHT-EMPTTLEGAEAAIKKQEDFMTTMDANEE--KINAVV 1229

Query: 1899 KHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
            +  ++ +   ++          +   EK++SI     K  E + + L+RL+ D+R+L+K+
Sbjct: 1230 ETGRRLVSDGNINS--------DRIQEKVDSIDDRHRKNRETASELLMRLK-DNRDLQKF 1280

Query: 1959 LTNQEE------------------KWKGMEEPGEKTELFCQALARKREQFESVAQLNNSL 2000
            L + +E                  + + +     K + F   LA  +E  + + +    L
Sbjct: 1281 LQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQL 1340

Query: 2001 KEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
                  E E ++ E    + +   +L   ++ + +      + + F     D+  W+  +
Sbjct: 1341 ISEK-PETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGL 1399

Query: 2061 KE------------SLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE-SS 2107
            +             S+ +L   +  +  +  ++K KEI  L+ +  A  +      E  S
Sbjct: 1400 ESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRK-KEIEELQSQAQALSQEGKSTDEVDS 1458

Query: 2108 EAPLVQKTLTDISNQWDNTLH--LASTYLSH-----QEKLLLEGEKY-LQSKED----LR 2155
            +   VQ    ++    +   H  LAS  +       ++++L  GE+  L +  D    L+
Sbjct: 1459 KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1518

Query: 2156 LMLIELKKKQEAGFALQHGLQEKKAQL-KIYKKFLKKAQDLTSL--------LKELKSQG 2206
             + + +KK Q     LQ  +Q  + ++  I+++      D +SL        L +LK   
Sbjct: 1519 TVQLLIKKNQ----TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLW 1574

Query: 2207 NYLLECTKN----------------PSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVRE 2250
              L+E T+                  +   E W+  + L+    ++ +D  Q+    +++
Sbjct: 1575 GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE-QSAVSMLKK 1633

Query: 2251 HDSYQVCVTDLNTTLDNFSK-------------EFVSFSDKPVDQI------AVEEKLQK 2291
            H   +  V D   T+   SK             E +S     VD++        EE+  K
Sbjct: 1634 HQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGK 1693

Query: 2292 LQELEN--RLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASA 2349
            L E     +L+ +   L++ +A  + V   +  +GQ    + +  LQ + ++      + 
Sbjct: 1694 LDERHRLFQLNREVDDLEQWIA-EREVVAGSHELGQDY--EHVTMLQERFREFARDTGNI 1750

Query: 2350 KQEMECCLNSILKSKRSTEKKGKFTLPGRE---KQATSDVQE----STQESAAVEKLEED 2402
             QE    +N +     ++      T+   +    +A +D+ E     TQ  AA  +L + 
Sbjct: 1751 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1810

Query: 2403 WEINKD----------SAVEMAMSKQLSLNAQESMKNTEDE------RKVNELQNQPLEL 2446
            +   K+             E     Q ++   + M  T +        +V +LQ     L
Sbjct: 1811 YHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL 1870

Query: 2447 DTMLRNEQLEEIEKLYTQ-LEAKKAAIKPLEQTEC-LNKTETGALVLHNIGYSAQHLDNL 2504
                  ++ ++I+K   + LEA K+ +   E     L  T         +      ++++
Sbjct: 1871 QAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1930

Query: 2505 LQALITLKKNKE--SQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIK- 2561
            ++ +   +K ++  S   ++ + Q   A +++   +  T  E  K          ++IK 
Sbjct: 1931 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1990

Query: 2562 KFIASIEKEKDSLGNLKIKWE----NLSNHVTDMDKKLLESQI---------KQLEHGWE 2608
            K +   EK K+ +   + +WE     L  H    D  + E+ +         +++    +
Sbjct: 1991 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD 2050

Query: 2609 QVEQQIQK--KYSQQVVEYDE-FTTL--MNKVQDTEISLQQQQQHLQLRLKSPE------ 2657
            +VE+ I++   + +    +DE F+ L  +  ++  E+  QQ+++  + R  SPE      
Sbjct: 2051 EVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2110

Query: 2658 ERAGNQSMIALTTDLQATKHGFSVLKGQAEL 2688
            E A +Q     +   Q +++G    +G   +
Sbjct: 2111 EEAESQQQWDTSKGEQVSQNGLPAEQGSPRM 2141



 Score = 47.0 bits (110), Expect = 7e-04
 Identities = 124/633 (19%), Positives = 254/633 (40%), Gaps = 104/633 (16%)

Query: 3566 KLLQKVQKNKEL--VQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQDH--PEK---- 3617
            K+L      K+L  V   + +  +F  E+      F+Q     ++M  ++H   EK    
Sbjct: 659  KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRER 718

Query: 3618 ----SEQFEELQ--SILKKGKLTFENIMEKLRIKYSE----MYTIVPAEIESQV------ 3661
                 EQ+  L+  S ++K +L   +++ + +    +    M  I+     S V      
Sbjct: 719  IIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYS 778

Query: 3662 -EECRKALEDIDEKISN-----EVLKSSPSYAMRRKIE--EINNGLHNVEKMLQQKSKNI 3713
             +   K  +D+ E+I+N     + L    S   +   E  ++   L  +E    ++ K +
Sbjct: 779  TQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIE----ERYKEV 834

Query: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIP--FQQYQQVSQ 3771
             +   ++K+   +    +   +E D+    I E++     +W++N+ IP   +  + +  
Sbjct: 835  AELTRLRKQALQDTLALYKMFSEADACELWIDEKE-----QWLNNMQIPEKLEDLEVIQH 889

Query: 3772 RAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSHHASTVQM 3829
            R E    ++N    ++   + + +     + ++ H       A  D L T       +  
Sbjct: 890  RFESLEPEMNNQASRVAVVNQIARQ----LMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945

Query: 3830 ALEDSEQKHNLLHSIFMDL-EDLSIIFETDELTQSIQELSNQ---VTALQQKIMESLPQI 3885
              +D+      + +  ++  E  S I E  ++ +S Q+L N    V ALQ+K+       
Sbjct: 946  RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTG----- 1000

Query: 3886 QRMADDVVAIESEVKSMEKRVSKIKT-------ILLSK--EIFDFSPE--EHLKHGEVIL 3934
              M  D+VAIE+++  ++K   K+++        +LS+  EI D   E    LK+ E  L
Sbjct: 1001 --MERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL 1058

Query: 3935 ENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVV 3994
                 +++ + ++  +Q  L   QT +    +    N L +  KLL   TQ +N     +
Sbjct: 1059 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLL---TQHEN-----I 1107

Query: 3995 IKQTNEWDEEIENLKQILNNYS-AQFSLEHMSPDQ-ADKLPQLQGEIERM---EKQILSL 4049
              + + ++E+ + ++ +    +  Q   ++M   Q    L     E+ +M    + +LS 
Sbjct: 1108 KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQ 1167

Query: 4050 NQRKEDLLVDLKATVLNL--------HQHLKQEQEGVERDRLPAVTSEEGGVAERDASER 4101
            +   +  L D K     L        H  +    EG E     A+  +E  +   DA+E 
Sbjct: 1168 SHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAE----AAIKKQEDFMTTMDANEE 1223

Query: 4102 KLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
            K+N     + +      V + ++ SD   EK +
Sbjct: 1224 KIN-----AVVETGRRLVSDGNINSDRIQEKVD 1251



 Score = 42.4 bits (98), Expect = 0.016
 Identities = 131/696 (18%), Positives = 255/696 (36%), Gaps = 143/696 (20%)

Query: 4661 NEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMW 4720
            ++I      + L   +    + +  E+++   + E E L      L +  K  D +DS  
Sbjct: 1401 SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKR 1460

Query: 4721 GMLRARYTELSSPFVTESQQDALLQGMV---------ELVKIGKE-----KLAHGHLKQT 4766
              ++ ++ EL  P + E + + L    +         E++ +G+         HGH  QT
Sbjct: 1461 LTVQTKFMELLEP-LNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQT 1519

Query: 4767 -----KSKVALQAQIENHK-----VF--FQKLVADMLLIQAYSAKILPSLLQNRETFWAE 4814
                 K    LQ +I+ H+     +F   Q +V D     + SA+ +   L + +  W  
Sbjct: 1520 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDS---SSLSAEAIRQRLADLKQLWGL 1576

Query: 4815 QVTEV----KILEEKSRQCGMKLQSL-LQKWEEFDENYASLE---KDLEILISTLPSVSL 4866
             + E     + LEE  R       +   + W    E Y   E   KD +  +S L    +
Sbjct: 1577 LIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQI 1636

Query: 4867 VEETEERLVERISFYQQIKRNIGG----KHARLYQTLNEGKQLVASVSCPELEGQIAKLE 4922
            +E+  E   E +    +  R +      +  R+    ++  +L A +     E +  KL+
Sbjct: 1637 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK-DLAEERRGKLD 1695

Query: 4923 EQW--LSLNKKID---------------HEL----HRLQALLKHLLSYNRDS-------- 4953
            E+     LN+++D               HEL      +  L +    + RD+        
Sbjct: 1696 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1755

Query: 4954 -------DQLTKWLESSQHTLNYWKEQSLNVSQDL----DTIRS------NINNFFEFSK 4996
                   D+L     S   T+  WK+       DL    DT          ++ F+  +K
Sbjct: 1756 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1815

Query: 4997 EV----------------DEKSSLKTA----------VISIGNQLLHLKETDTATLRASL 5030
            E+                 ++++++T           + ++G Q+  L+E D A L+A+ 
Sbjct: 1816 EIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE-DAARLQAAY 1874

Query: 5031 A------------QFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQ 5078
            A            +  + W  L+      + +L     +K      + +++ WM +V  Q
Sbjct: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG-DKFRFFSMVRDLMLWMEDVIRQ 1933

Query: 5079 TSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL---LQLSTCDVESKRY 5135
               ++    P   S V+ L+  H+  + E+D +       N S    ++L    +  K Y
Sbjct: 1934 IEAQEK---PRDVSSVELLMNNHQGIKAEIDAR-------NDSFTTCIELGKSLLARKHY 1983

Query: 5136 ERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKT 5195
               E  E L ++  +   +      + + L  +LE + +      +   WL  QE  L +
Sbjct: 1984 ASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEPYLSS 2042

Query: 5196 LQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQ 5231
             +  +SV  V+KL+   +  E   A   +    L++
Sbjct: 2043 REIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2078



 Score = 42.0 bits (97), Expect = 0.021
 Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 10/209 (4%)

Query: 6539 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 6598
            + ++ H +L+     QQ   D +    W+  +E EL M+   K   +   + + +K+ Q 
Sbjct: 1580 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1636

Query: 6599 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 6656
            + +A + Y   V  ++ +S+  +    PES  +  R  ++  L+   +   +  RG L  
Sbjct: 1637 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1696

Query: 6657 RQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVER 6716
            R  L Q    ++   +L  W+A  +       +         L E  RE  +    +   
Sbjct: 1697 RHRLFQ---LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI--G 1751

Query: 6717 QPQVDMLQEISNSLLIKGHGEDCIEAEEK 6745
            Q +VD +  +++ L+  GH +    AE K
Sbjct: 1752 QERVDTVNHLADELINSGHSDAATIAEWK 1780



 Score = 40.8 bits (94), Expect = 0.047
 Identities = 45/234 (19%), Positives = 104/234 (44%), Gaps = 22/234 (9%)

Query: 6504 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 6561
            KEG ++++  P+ E    A + E+ +G    WE++++  Q    +L      +      +
Sbjct: 1335 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390

Query: 6562 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 6621
             +  WL   E++++     K   D+  + + +K+ Q +    +  K  +  +  S  + L
Sbjct: 1391 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQMLENQMEVRKKEIEELQ-SQAQAL 1446

Query: 6622 QTESPESTELQS-RLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNL---LLWL 6677
              E   + E+ S RL   +   E  +   +      + +L+  ++ HQ ++++   +LW+
Sbjct: 1447 SQEGKSTDEVDSKRLTVQTKFMELLEPLNER-----KHNLLASKEIHQFNRDVEDEILWV 1501

Query: 6678 ASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLL 6731
                 R   A  TD   + + +    ++   L+KE+   QP++D + E S +++
Sbjct: 1502 GE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1552



 Score = 38.9 bits (89), Expect = 0.18
 Identities = 97/509 (19%), Positives = 202/509 (39%), Gaps = 38/509 (7%)

Query: 4643 KRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESR--VAKLRDEGERLH 4700
            + LY    +     Q +++ +    + EQ  +  A TV   +  SR  VA    E ER+ 
Sbjct: 1611 QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERIS 1670

Query: 4701 LPYALLQEVYK-LEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVEL-VKIGKEKL 4758
            +  + + ++Y  L+D+ +   G L  R+      F    + D L Q + E  V  G  +L
Sbjct: 1671 MRQSKVDKLYAGLKDLAEERRGKLDERHRL----FQLNREVDDLEQWIAEREVVAGSHEL 1726

Query: 4759 AHGHLKQTKSKVALQ------AQIENHKVFFQKLVADMLLIQAYS-AKILPSLLQNRETF 4811
               +   T  +   +        I   +V     +AD L+   +S A  +          
Sbjct: 1727 GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEA 1786

Query: 4812 WAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETE 4871
            WA+ +   ++++ +++      + L + + +  E +  ++   + L   L       ET 
Sbjct: 1787 WADLL---ELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETL 1842

Query: 4872 ERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKK 4931
            +R+    +F   I+  +G +  +L +     +   A     +++ +  ++ E W SL   
Sbjct: 1843 QRM--HTTFEHDIQA-LGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDA 1899

Query: 4932 IDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNF 4991
             +    RL         ++   D L  W+E     +     ++    +D+ ++   +NN 
Sbjct: 1900 CESRRVRLVDTGDKFRFFSMVRD-LMLWMEDVIRQI-----EAQEKPRDVSSVELLMNNH 1953

Query: 4992 FEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
                 E+D ++   T  I +G  LL  K   +  ++  L Q  +K   +I +  D  E L
Sbjct: 1954 QGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWL 2013

Query: 5052 HQ-LQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDY 5110
               L++ +     ++ E  +W+   E   S  +      S  +V+ L+++H+ F  E   
Sbjct: 2014 RLILEVHQFSRDASVAE--AWLLGQEPYLSSRE---IGQSVDEVEKLIKRHEAF--EKSA 2066

Query: 5111 KQWIVDFVNQSLLQLSTCDVESKRYERTE 5139
              W   F   +L +L+T ++   R ++ E
Sbjct: 2067 ATWDERF--SALERLTTLELLEVRRQQEE 2093



 Score = 33.1 bits (74), Expect = 9.8
 Identities = 58/281 (20%), Positives = 116/281 (41%), Gaps = 25/281 (8%)

Query: 6500 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 6557
            +D  KE  ++ + +P Q    L+ + E      D WE ++    + +  + +   LQQ  
Sbjct: 1013 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1068

Query: 6558 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 6617
             D+    +WL +T+  +    M   P+ + E E  + + + I    D Y+     +    
Sbjct: 1069 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1125

Query: 6618 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLM-QCQDFHQLSQNLLL 6675
            +   Q ++  +   L+ RL+ L   W         W    RQ+L+ Q   + Q  ++   
Sbjct: 1126 EMVTQGQTDAQYMFLRQRLQALDTGWNELH---KMWEN--RQNLLSQSHAYQQFLRDTKQ 1180

Query: 6676 WLASAKNRRQ-KAHVTDPKA--DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 6732
              A   N+    AH   P       A ++ + + M     +   + +++ + E    L+ 
Sbjct: 1181 AEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFM---TTMDANEEKINAVVETGRRLVS 1237

Query: 6733 KGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 6772
             G+   D I  +EKV  I+ + ++ RE  S+ LM L+  ++
Sbjct: 1238 DGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1276


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  198 bits (503), Expect = 2e-49
 Identities = 117/281 (41%), Positives = 163/281 (58%), Gaps = 35/281 (12%)

Query: 24  SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD- 82
           +L  E+E  QKK FT W+NS LAR T    + DL++D++ G  LL LLEVLSG+ LP+  
Sbjct: 50  ALADEREAVQKKTFTKWVNSHLARVTCR--VGDLYSDLRDGRNLLRLLEVLSGEILPKPT 107

Query: 83  KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
           KG     C  N++ AL FL+ + + L N+   DI+DGN  + LGL+WTIIL F I+ ++ 
Sbjct: 108 KGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISV 167

Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
               N                              + + SA+ ALLLW Q + A Y +VN
Sbjct: 168 ETEDN------------------------------KEKKSAKDALLLWCQMKTAGYPNVN 197

Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
           V +F +SWR+G+AF AI+H  RPDL+D +S+K  +   NL+ AF +AE+EL + +LL+PE
Sbjct: 198 VHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPE 257

Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQ--GKVKD 301
           DV+V  PDEKSI+TYVA +  Y         E +  GKV D
Sbjct: 258 DVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLD 298



 Score = 70.1 bits (170), Expect = 7e-11
 Identities = 119/657 (18%), Positives = 269/657 (40%), Gaps = 65/657 (9%)

Query: 5705 FTTSVENLFRFLTDTSHLLSAVK-GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLE 5763
            F     ++  +L D   L+S+ + G + FS  Q  +  H    +EI    R T  AL  +
Sbjct: 752  FQADANDMEAWLVDALRLVSSPELGHDEFST-QALARQHRALEEEIR-SHRPTLDALREQ 809

Query: 5764 AGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ------CEK 5817
            A     L   L     V  R+  L+  +++++ +  E  +  ++ +  +        C  
Sbjct: 810  AAA---LPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGL 866

Query: 5818 KIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR 5877
             ++E +  L  L       LPE  EDL   ++  + LE  + +    +  +  +   L +
Sbjct: 867  WVEEKEQWLNGLA------LPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920

Query: 5878 HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME 5937
                    ++  Q E L+ +W+        +K  +   L+    ++ +  E  AW+ + +
Sbjct: 921  ANPPGKDRIVNTQ-EQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMRE-K 977

Query: 5938 NKVLQTA-----DISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEI 5992
             KV+++      D++    +++       ++   +    +L +  + L  A + ++A  I
Sbjct: 978  TKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALA-AGHPAQAVAI 1036

Query: 5993 DDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYD 6052
            + +L ++   W+ L   +  R + L E    +Q   +++ + + WL R ++ ++      
Sbjct: 1037 NARLREVQTGWEDLRATMRRREESLGEARR-LQDFLRSLDDFQAWLGRTQTAVASEE--G 1093

Query: 6053 VCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRS 6112
                 E +  LA+   L+ ++E+  +    +  + + +  D      + +C  ++Q   +
Sbjct: 1094 PATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQA----DPQCLFLRQRLEA 1149

Query: 6113 LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSA 6172
            L   W  +  M   R+ ++ +    +Q FL D  + E  L S E   +        +T  
Sbjct: 1150 LGTGWEELGRMWESRQGRLAQAHG-FQGFLRDARQAEGVLSSQEYVLS--------HTEM 1200

Query: 6173 KEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRR 6232
               L+  +A  +++ + ++ ++   ++   L    R        Q+V EGN   D ++ +
Sbjct: 1201 PGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGR--------QLVSEGNIHADKIREK 1252

Query: 6233 VTAVLRRLRHFTNQREEFEG----TRE---------SILVWLTEMDLQLTNVEHFSESDA 6279
              ++ RR +   +  ++F G     RE          + +W+ E  L   +V +    + 
Sbjct: 1253 ADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNL 1312

Query: 6280 DDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEV 6336
              K ++   F  E+  N + +D++   G +L  +   L A L+ ++L +LHR   E+
Sbjct: 1313 HTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA-LVSEKLRDLHRRWDEL 1368



 Score = 63.9 bits (154), Expect = 5e-09
 Identities = 105/550 (19%), Positives = 223/550 (40%), Gaps = 60/550 (10%)

Query: 5781 GRRISQLQDSWKDMEPQL-------AEMIKQFQSTVETWD--QCEKKIKELKSRLQVLKA 5831
            G+RI ++ D   + E  +       +E+++  + T+ T +  Q    +  ++++LQ   +
Sbjct: 290  GKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNS 349

Query: 5832 QSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQI 5891
                  P    +  N + L+  ++  L +  Q +   +  +       L+ D+    E++
Sbjct: 350  YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGR-------LISDINKAWERL 402

Query: 5892 EHLHRQWEDLCLRVAIRKQEIEDRL-----------NTWVVFNEKNKELCAWLVQMENKV 5940
            E    + E L LR  + +QE  ++L            TW+  N++       LV  +N  
Sbjct: 403  EKAEHERE-LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQR-------LVSQDNFG 454

Query: 5941 LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN 6000
            L+ A  ++E  + K   + +E   +    ++Q        + A        I  + + + 
Sbjct: 455  LELA--AVEAAVRK--HEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVA 510

Query: 6001 DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ 6060
              W  L  ++ +R ++L      +Q++ +++  L  W+  ++  L           Q++ 
Sbjct: 511  RLWDFLRQMVAARRERLLLNLE-LQKVFQDLLYLMDWMEEMKGRLQS---------QDLG 560

Query: 6061 KRLAEQQDLQRDIEQHSAGV----ESVFNICDVLLHDSDACANETECDS--IQQTTRSLD 6114
            + LA  +DL +  E   A +    E V  +    L   +       CD   + +    L+
Sbjct: 561  RHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLE 620

Query: 6115 RRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKE 6174
            + +  +C ++  RR ++EE+ RLW +FL +    E W++  +   A  ++   L T A  
Sbjct: 621  QSYEALCELAAARRARLEESRRLW-RFLWEVGEAEAWVREQQHLLASADTGRDL-TGALR 678

Query: 6175 ELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVT 6234
             L +  A + ++  RL  L+L  +Q ++L  E     AS+      E   +W+ L+    
Sbjct: 679  LLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG-ASQASARAAELQAQWERLEALAE 737

Query: 6235 AVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVE-HFSESDADDKMRQLNGFQQEI 6293
               +RL    +   +F+     +  WL +    +++ E    E       RQ    ++EI
Sbjct: 738  ERAQRLAQAAS-LYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796

Query: 6294 TLNTNKIDQL 6303
              +   +D L
Sbjct: 797  RSHRPTLDAL 806



 Score = 59.3 bits (142), Expect = 1e-07
 Identities = 86/459 (18%), Positives = 190/459 (41%), Gaps = 36/459 (7%)

Query: 5890 QIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME----------NK 5939
            ++  L   W+ L   + +R + +ED L     + +   E  AW+ + E          ++
Sbjct: 1562 ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDA-AEAEAWMGEQELHMMGQEKAKDE 1620

Query: 5940 VLQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKI 5999
            +   A++   +++E+   D  + I+       QL      +I   +   +  I  +  ++
Sbjct: 1621 LSAQAEVKKHQVLEQALADYAQTIH-------QLAASSQDMIDHEHPE-STRISIRQAQV 1672

Query: 6000 NDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEI 6059
            +  +  L ++ G R ++L+E     Q L + + +L  W+   E   +    +++  D E 
Sbjct: 1673 DKLYAGLKELAGERRERLQEHLRLCQ-LRRELDDLEQWIQEREVVAAS---HELGQDYEH 1728

Query: 6060 QKRLAEQ-QDLQRDIEQ-HSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRW 6117
               L ++ ++  RD        V+S   + + L+    A        ++ +   SL+  W
Sbjct: 1729 VTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA-----TVAEWKDSLNEAW 1783

Query: 6118 RNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELK 6177
             ++  +   R   +   + L Q+FL  +   +   +   +    P+ +     +A+   +
Sbjct: 1784 ADLLELLDTRGQVLAAAYEL-QRFL--HGARQALARVQHKQQQLPDGTGRDLNAAEALQR 1840

Query: 6178 RFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL 6237
            R  A++  I     Q++ +     RL +    D A  + + +    + W  LQ    A  
Sbjct: 1841 RHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARR 1900

Query: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE-SDADDKMRQLNGFQQEITLN 6296
            + L   T++   F+  RE +++W+ E++LQ+   E   + S AD  ++   G + EI   
Sbjct: 1901 QLLLDTTDKFRFFKAVRE-LMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR 1959

Query: 6297 TNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335
             ++    I  G++L+ +S    A  I ++L +L    QE
Sbjct: 1960 ADRFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQE 1997



 Score = 52.8 bits (125), Expect = 1e-05
 Identities = 60/247 (24%), Positives = 101/247 (40%), Gaps = 20/247 (8%)

Query: 6507 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQ-ELHNK-LKIKQNLQQLNSDISAIT 6564
            PR+ +   +Q   G A    + +   + W+ +  + EL  K L+     QQ   D +   
Sbjct: 1542 PRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601

Query: 6565 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTE 6624
             W+   E EL M+   K   ++   +  VK+ Q + +A   Y   +  +  SS++ +  E
Sbjct: 1602 AWMG--EQELHMMGQEKAKDELSA-QAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658

Query: 6625 SPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQ------DFHQLSQNLLLWLA 6678
             PEST +  R  Q+  L+   +      R  L++ L  CQ      D  Q  Q   +  A
Sbjct: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718

Query: 6679 SAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGED 6738
            S +  +   HVT  +   R   E  R+   + +E      +VD    ++N L+  GH   
Sbjct: 1719 SHELGQDYEHVTMLRDKFR---EFSRDTSTIGQE------RVDSANALANGLIAGGHAAR 1769

Query: 6739 CIEAEEK 6745
               AE K
Sbjct: 1770 ATVAEWK 1776



 Score = 47.0 bits (110), Expect = 7e-04
 Identities = 47/229 (20%), Positives = 98/229 (42%), Gaps = 17/229 (7%)

Query: 6535 WEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 6592
            +E +QA+  E    L+    L  + S+  A   W+++ E  L  L +   P  ++++E+ 
Sbjct: 834  YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLAL---PERLEDLEVV 890

Query: 6593 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 6652
             +R + +    +T  A + +VN  +++ L+   P    + +   QL+  W+  +   D  
Sbjct: 891  QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950

Query: 6653 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKA----DPRALLECRRELMQ 6708
            +  L  S +  Q++H        W+      R+K  V +       D   +L  +R+L  
Sbjct: 951  KAAL-TSALSIQNYHLECTETQAWM------REKTKVIESTQGLGNDLAGVLALQRKLAG 1003

Query: 6709 LEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6757
             E++L     +V  L   +N+ L  GH    +    ++  ++   + LR
Sbjct: 1004 TERDLEAIAARVGELTREANA-LAAGHPAQAVAINARLREVQTGWEDLR 1051



 Score = 35.0 bits (79), Expect = 2.6
 Identities = 69/349 (19%), Positives = 139/349 (39%), Gaps = 21/349 (6%)

Query: 4635 NRSYQNEIKRLYHQL---IKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAK 4691
            NR  Q+ ++   H+L   I  K    Q ++    +++  + QK  A+  EL   +  + K
Sbjct: 1277 NREQQHFLQDC-HELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDK 1335

Query: 4692 LRDEGERLHLPYALLQEVY--KLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
            +  EG  L L    L+ +   KL D L   W  L       +      ++ +   Q    
Sbjct: 1336 VDKEGRELTLEKPELKALVSEKLRD-LHRRWDELETTTQAKARSLFDANRAELFAQSCCA 1394

Query: 4750 LVKIGKEKLAHGHLKQT-KSKVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNR 4808
            L    +   A  H     K   ++   ++  ++   ++      ++A  A+      +++
Sbjct: 1395 LESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ 1454

Query: 4809 ETFWAEQVTEVKILEEKSRQCGMKLQSL---LQKWEEFDENYASLEKDLEILISTLPSVS 4865
                 E+ +  + +EEK R     ++     LQ   E  + +  +E ++  +   LP  S
Sbjct: 1455 GAGEVERTS--RAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMAS 1512

Query: 4866 LVEETEERLVERISFY--QQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEE 4923
             +E  ++    ++     Q +++ I G   R+       + L A+ + PEL    A+L+E
Sbjct: 1513 SMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPEL----AELQE 1568

Query: 4924 QWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWL-ESSQHTLNYWK 4971
             W  L  +++    RL+  L+    Y RD+ +   W+ E   H +   K
Sbjct: 1569 MWKRLGHELELRGKRLEDALRAQQFY-RDAAEAEAWMGEQELHMMGQEK 1616



 Score = 33.9 bits (76), Expect = 5.7
 Identities = 91/577 (15%), Positives = 217/577 (37%), Gaps = 68/577 (11%)

Query: 4822 LEEKSRQC-GMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISF 4880
            +EEK +   G+ L   L+  E   + + +LE ++  L + + +V+ + E           
Sbjct: 868  VEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAE----------- 916

Query: 4881 YQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
             Q +K N  GK  R+  T  +                   L  +W    +  D +   L 
Sbjct: 917  -QLLKANPPGKD-RIVNTQEQ-------------------LNHRWQQFRRLADGKKAALT 955

Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
            + L  + +Y+ +  +   W+      +    E +  +  DL  + +         ++++ 
Sbjct: 956  SALS-IQNYHLECTETQAWMREKTKVI----ESTQGLGNDLAGVLALQRKLAGTERDLEA 1010

Query: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
             ++    +    N L          + A L + +  W  L   +   +E L + +  +  
Sbjct: 1011 IAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ-D 1069

Query: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ 5120
              +++ +  +W+   +   + E+    P++  + + LL +H   R E++  Q     +  
Sbjct: 1070 FLRSLDDFQAWLGRTQTAVASEEG---PATLPEAEALLAQHAALRGEVERAQSEYSRLRA 1126

Query: 5121 SLLQLSTCDVESKRYERTEFAEHLG----EMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
               +++    + +     +  E LG    E+ R W    G L  +    +  L    ++E
Sbjct: 1127 LGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL-AQAHGFQGFLRDARQAE 1185

Query: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL 5236
                     L +QE  L   + P ++ +    +   +D  + +    + +  L      L
Sbjct: 1186 GV-------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGL------L 1232

Query: 5237 ESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIY-DQLYDEVNMMTIR 5295
            E+G   L+ +     D++ +K  S+  +  + + + Q  L   +   +Q +   +   ++
Sbjct: 1233 EAGR-QLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELK 1291

Query: 5296 FWYCMEHSKPVVLSLE---TLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVA 5352
             W   +      +S +    L  + +  Q+   E  +++   +K+ +   +L    P + 
Sbjct: 1292 LWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELK 1351

Query: 5353 EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389
             ++ EK ++ H+RW ++         KA+SL    +A
Sbjct: 1352 ALVSEKLRDLHRRWDELETTTQ---AKARSLFDANRA 1385


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  197 bits (501), Expect = 3e-49
 Identities = 124/327 (37%), Positives = 182/327 (55%), Gaps = 49/327 (14%)

Query: 24  SLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRD- 82
           +L  E+E  QKK FT W+NS LAR +    I+DL+ D++ G +L+ LLEVLSG+ LP+  
Sbjct: 47  ALADEREVVQKKTFTKWVNSHLARVSCR--ITDLYKDLRDGRMLIKLLEVLSGEMLPKPT 104

Query: 83  KGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142
           KG     C  N++ AL FL+ + + L N+   DI+DGN  ++LGLIWTIIL F I+ +  
Sbjct: 105 KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI-- 162

Query: 143 TLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESVN 202
                          VV +              + R   SA+ ALLLW Q + A Y  VN
Sbjct: 163 ---------------VVQTQ-------------EGRETRSAKDALLLWCQMKTAGYPHVN 194

Query: 203 VTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEPE 262
           VT+F SSW++G+AF A+IH  RPDLID   +K  + + NL  AF +AE++L I  LL+PE
Sbjct: 195 VTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPE 254

Query: 263 DVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDS-E 321
           DV   +PDEKSI+TYV  F  Y                  M  L ++ +++ K++  + E
Sbjct: 255 DVFTENPDEKSIITYVVAFYHYF---------------SKMKVLAVEGKRVGKVIDHAIE 299

Query: 322 NDTYFKKYNSLLSFMESFNEEKKSFLD 348
            +   +KY+ L S + ++ E+  + L+
Sbjct: 300 TEKMIEKYSGLASDLLTWIEQTITVLN 326



 Score = 86.7 bits (213), Expect = 7e-16
 Identities = 140/667 (20%), Positives = 274/667 (41%), Gaps = 84/667 (12%)

Query: 4770 VALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQC 4829
            +A+Q ++   +     + A +  ++  S +++ S  + +E     Q    K LEE  +  
Sbjct: 991  IAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ----KHLEELWQGL 1046

Query: 4830 GMKLQSLLQKWEEFDENYASLEK--DLEILISTLPSVSLVEETEERLVERISFYQQ---I 4884
               LQ       E  +  A L+   D +  +S        E+  E L E     QQ   I
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106

Query: 4885 KRNIGGKHARLYQTLNE-GKQLVASVSCPE---LEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
            K  I G H   YQ + E G++++   + PE   L  ++  L+  W +L +  +   H L 
Sbjct: 1107 KDEIDG-HQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165

Query: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
              L     + +D+ Q    L + ++TL +     L     L+   + I  F +F   ++ 
Sbjct: 1166 QCLG-FQEFQKDAKQAEAILSNQEYTLAH-----LEPPDSLEAAEAGIRKFEDFLGSMEN 1219

Query: 5001 KSSLKTAVISIGNQLLHLKETDTATLRASLAQFE----------QKWTMLITQLPDIQEK 5050
                  + +  GN+L+      +  ++  +   E          Q+ ++L+    ++Q  
Sbjct: 1220 NRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNF 1279

Query: 5051 LHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEM-D 5109
            L   Q           E+  W+N+    + D     S   A  + +   KH+ F  E+  
Sbjct: 1280 LQNCQ-----------ELTLWINDKLLTSQDV----SYDEARNLHNKWLKHQAFVAELAS 1324

Query: 5110 YKQWIVDFVNQSLLQLSTCDVESKRY--ERTEF----AEHLGEMNRQWHRVHGMLNRKIQ 5163
            ++ W           L   D E K+   E+ +F    ++ L  ++R W  +      K Q
Sbjct: 1325 HEGW-----------LENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ 1373

Query: 5164 HLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKS 5223
            HL     S    +     LN W+ A E++L++    + + SV ++L   + +E+Q+ ++ 
Sbjct: 1374 HLSAARSSDLRLQTHAD-LNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRK 1432

Query: 5224 KALDELKQSYLTLESGAVPLLEDTASRIDELFQKR-SSVLTQVNQLKTSMQSVLQEWKIY 5282
            + L EL           VP + +     D   +KR   +L  + + K  ++S   + +I 
Sbjct: 1433 EELGEL--------FAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQIS 1484

Query: 5283 DQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIG 5342
              L DE   +  R    +  S     +L+T++  ++  Q+LQ+E     G   ++++V+ 
Sbjct: 1485 RDLEDETLWVEERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEI---LGHTPRVEDVLQ 1539

Query: 5343 KLKGLCPSVAEI----IEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAA 5398
            + + L    AEI    +EE+  +    W ++ +A A +LQ+ +   +  + Y +A  EA 
Sbjct: 1540 RGQQLV-EAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAE 1597

Query: 5399 ARLKQQE 5405
            A + +QE
Sbjct: 1598 AWIGEQE 1604



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 247/1271 (19%), Positives = 483/1271 (38%), Gaps = 214/1271 (16%)

Query: 5161 KIQHLEQLLESITESEN----------KIQILNNWLEAQEERLKTLQKPESVISVQKLLL 5210
            +++ LE L + + E EN          K  IL  W   QE      Q+ E+ +++QKL  
Sbjct: 477  RVRALEDLAQEL-EKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLF- 534

Query: 5211 DCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKR----SSVLTQVN 5266
              QD+ + +      +DE+K   L+ E G   LLE     +++L QK     + +  Q +
Sbjct: 535  --QDMLHSI----DWMDEIKAHLLSAEFGK-HLLE-----VEDLLQKHKLMEADIAIQGD 582

Query: 5267 QLKTSMQSVLQ--EWKIYDQLYDEVNMMTI-RFWYCMEHSKPVVLSLETLRCQVENLQSL 5323
            ++K    + L+  E K Y     +V    I     C E    +    +    Q + L   
Sbjct: 583  KVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKF 642

Query: 5324 QDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSL 5383
              E + +E SW K +E I         +  ++    Q  HK       A  D+L+   + 
Sbjct: 643  FWEMDEAE-SWIKEKEQIYSSLDYGKDLTSVLI--LQRKHK-------AFEDELRGLDAH 692

Query: 5384 LQLWKAYSNAHGEAA----------ARLKQQEAKFQQLANISMSGNNLAEILPPALQDIK 5433
            L+  + +  AHG  A          AR+K+  A++ QL        +LA      LQD +
Sbjct: 693  LE--QIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQL-------KDLAAFCKKNLQDAE 743

Query: 5434 ---ELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKAN 5490
               + Q D    K A+LQ++              H LL G        A           
Sbjct: 744  NFFQFQGDADDLK-AWLQDA--------------HRLLSGEDVGQDEGAT---------- 778

Query: 5491 EFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEH 5550
                +  + KDF   LE  +G++ H       L QQ +  P+ F +        SPD+ H
Sbjct: 779  --RALGKKHKDFLEELEESRGVMEH-------LEQQAQGFPEEFRD--------SPDVTH 821

Query: 5551 LNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLE 5610
                          ++ L+ + +Q +       +R  E   +         CE W+   E
Sbjct: 822  -------------RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMG--E 866

Query: 5611 KIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEF 5670
            K +   ++++ ++L +L   Q  + +L+ E+    T  D     +  L+++    +R E 
Sbjct: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EV 925

Query: 5671 ITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK--G 5728
                  L  RWQ     V +R+  VD  +R   ++    E   +++TD + ++ + K  G
Sbjct: 926  KQYQDHLNTRWQAFQTLVSERREAVDSALRV-HNYCVDCEETSKWITDKTKVVESTKDLG 984

Query: 5729 QERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQ 5788
            ++   +   +  +  L+      Q R       LE   + L+ +  + KE +G+R   L+
Sbjct: 985  RDLAGIIAIQRKLSGLERDVAAIQARVDA----LERESQQLMDSHPEQKEDIGQRQKHLE 1040

Query: 5789 DSWKDMEPQLAEM------IKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHE 5842
            + W+ ++  L         + Q Q+ ++  D  +  +    ++  V      + LPE  +
Sbjct: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLS--ITQKAVASEDMPESLPEAEQ 1098

Query: 5843 DLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLC 5902
             L     +  E++    S+ Q +KE       + +     + ++L +++E L   W  L 
Sbjct: 1099 LLQQHAGIKDEIDGHQDSY-QRVKE---SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALG 1154

Query: 5903 LRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ------ 5956
                 R   +   L     F E  K+       + N+    A +   + +E  +      
Sbjct: 1155 RMWESRSHTLAQCLG----FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKF 1210

Query: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASN------KSRAAEIDDKLNKINDRWQHLFDVI 6010
            +D +  +    +  L     G++L+   N      K +   I+D+  K N++ Q    ++
Sbjct: 1211 EDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLL 1270

Query: 6011 GSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQ 6070
               ++        +Q   +N   L  W+   +   S+ V YD  + + +  +  + Q   
Sbjct: 1271 RDNLE--------LQNFLQNCQELTLWI-NDKLLTSQDVSYD--EARNLHNKWLKHQAFV 1319

Query: 6071 RDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMK 6130
             ++  H   +E++      L+ +            + Q   +L R W  + A + E+   
Sbjct: 1320 AELASHEGWLENIDAEGKQLMDEKPQFT-----ALVSQKLEALHRLWDELQATTKEKTQH 1374

Query: 6131 IEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERL 6190
            +    R     L  ++    W+ + E      +  + L TS    L + +  + Q++ R 
Sbjct: 1375 LSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDPGKDL-TSVNRMLAKLKRVEDQVNVR- 1431

Query: 6191 TQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVL----RRLRHFTNQ 6246
                          +E   +  +++  M  EG     ++++R   +L    RR +   + 
Sbjct: 1432 --------------KEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESS 1477

Query: 6247 REEFEGTR--ESILVWLTEMDLQLTNVEHFSES--DADDKMRQLNGFQQEITLNTNKIDQ 6302
            R + + +R  E   +W+ E  L L     +  +       M++    Q EI  +T +++ 
Sbjct: 1478 RAKLQISRDLEDETLWVEER-LPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536

Query: 6303 LIVFGEQLIQKSEPLDAVLIEDELEELH----RYCQEVFGRVSRFHRRLTSCTPGLEDEK 6358
            ++  G+QL++ +E +D   +E+ L  L     R  +   GR+ R           L D  
Sbjct: 1537 VLQRGQQLVEAAE-IDCQDLEERLGHLQSSWDRLREAAAGRLQR-----------LRDAN 1584

Query: 6359 EASENETDMED 6369
            EA +   D ++
Sbjct: 1585 EAQQYYLDADE 1595



 Score = 80.9 bits (198), Expect = 4e-14
 Identities = 321/1828 (17%), Positives = 685/1828 (37%), Gaps = 246/1828 (13%)

Query: 4673 QKADAYTVELENAESRVAKLRDEGERLHLP-YALLQEVYKLEDVLDSMWGMLRARYTELS 4731
            +K +A   +    E RV  L D  + L    Y   + +   +D +  +W  L+       
Sbjct: 462  KKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRR 521

Query: 4732 SPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQ--IENHKVFFQKLVAD 4789
                T      L Q M+  +    E  AH  L     K  L+ +  ++ HK+    +   
Sbjct: 522  QRLETTLALQKLFQDMLHSIDWMDEIKAH-LLSAEFGKHLLEVEDLLQKHKLMEADIAIQ 580

Query: 4790 MLLIQAYSAKIL------------PSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL 4837
               ++A +A  L            P ++Q+R +   +   E+  +    +    + + L 
Sbjct: 581  GDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLW 640

Query: 4838 QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ 4897
            + + E DE  + +++  +I  S      L   T   +++R   ++  +  + G  A L Q
Sbjct: 641  KFFWEMDEAESWIKEKEQIYSSLDYGKDL---TSVLILQRK--HKAFEDELRGLDAHLEQ 695

Query: 4898 TLNEGKQLVA--SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQ 4955
               E   +VA      P++E +I ++  QW  L          LQ   ++   +  D+D 
Sbjct: 696  IFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADD 754

Query: 4956 LTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQL 5015
            L  WL+ +   L+       +V QD    R+      +F +E++E   +      +  Q 
Sbjct: 755  LKAWLQDAHRLLS-----GEDVGQDEGATRALGKKHKDFLEELEESRGVME---HLEQQA 806

Query: 5016 LHLKET--DTATLRASLAQFEQKWTMLITQLPDIQEKLHQ-LQMEKLPSRKAITEMISWM 5072
                E   D+  +   L    + +  ++ Q    Q++L + L +  +       E+  WM
Sbjct: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL--WM 864

Query: 5073 NNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVES 5132
               E   ++   +  P +   ++ +  +      EM      +D VN +   L    VES
Sbjct: 865  GEKEKWLAE---MEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL----VES 917

Query: 5133 KRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEER 5192
                  E  ++   +N +W     +++ + + ++  L            ++N+    EE 
Sbjct: 918  GHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALR-----------VHNYCVDCEET 966

Query: 5193 LKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRID 5252
             K +     V+   K L   +D+   +AI+ K L  L++    +++    L  ++   +D
Sbjct: 967  SKWITDKTKVVESTKDL--GRDLAGIIAIQRK-LSGLERDVAAIQARVDALERESQQLMD 1023

Query: 5253 ELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMT--------IRFWYCMEH-- 5302
               +++  +  +   L+   Q + Q  +  + L  EV+ +          + W  +    
Sbjct: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083

Query: 5303 --SKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGK-LKGLCPSVAEIIEEKC 5359
              S+ +  SL      ++    ++DE +  + S+++++E   K ++G       ++ ++ 
Sbjct: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143

Query: 5360 QNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGN 5419
            +     W               +L ++W++ S+   +     + Q+   Q  A +S    
Sbjct: 1144 EGLDTGWN--------------ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189

Query: 5420 NLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAA 5479
             LA + PP    ++  +  ++K ++      +  D++  P +S   ++  G L+S +   
Sbjct: 1190 TLAHLEPP--DSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK--- 1244

Query: 5480 YLEKMLLV---------KANEFEFVLSQFKDFGVRLESLKGLIMHEEENL----DRLHQQ 5526
              EK+ L+         KA E   +L    +    L++ + L +   + L    D  + +
Sbjct: 1245 IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDE 1304

Query: 5527 EKENPDSFLNH---VLALTAQSPDIEHLNEVSLKL-----PLSDVAVKTLQNMNRQWIRA 5578
             +   + +L H   V  L +    +E+++    +L       + +  + L+ ++R W   
Sbjct: 1305 ARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDEL 1364

Query: 5579 TATALERCSELQGIGLNEKFLYC---CEKWIQLLEKIEEALKVDVANSLPELLEQQKTYK 5635
             AT  E+   L     ++  L       KWI  +E  ++    D    L  +       K
Sbjct: 1365 QATTKEKTQHLSAARSSDLRLQTHADLNKWISAME--DQLRSDDPGKDLTSVNRMLAKLK 1422

Query: 5636 MLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDV 5695
             +E +V++ +                   E   E   +   + +   +A   + +R  D+
Sbjct: 1423 RVEDQVNVRK-------------------EELGELFAQVPSMGEEGGDADLSIEKRFLDL 1463

Query: 5696 -DGLVRQWQDFTTSVENL--FRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQ 5752
             + L R+ +   +S   L   R L D +  +     +ER  L Q+      L+  ++  +
Sbjct: 1464 LEPLGRRKKQLESSRAKLQISRDLEDETLWV-----EERLPLAQSADYGTNLQTVQLFMK 1518

Query: 5753 RRRTT----------CALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMI 5802
            + +T               L+ G++L+   ++  ++ +  R+  LQ SW  +    A  +
Sbjct: 1519 KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD-LEERLGHLQSSWDRLREAAAGRL 1577

Query: 5803 KQFQSTVETW------DQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQ 5856
            ++ +   E        D+ E  I E    L V+     D +P+  E      +     ++
Sbjct: 1578 QRLRDANEAQQYYLDADEAEAWIGE--QELYVIS----DEIPKDEEGAIVMLKRHLRQQR 1631

Query: 5857 SLASWTQNLKELQTMKADLTR--HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIED 5914
            ++  + +N+K+L +    L    H   E ++ L+ Q++  +   +D+      RK+++E+
Sbjct: 1632 AVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE---RKRKLEN 1688

Query: 5915 RLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCMEEINLFSENKL 5971
              + + +  E + +L  W+ + E   +      D     ++    +D   E     + ++
Sbjct: 1689 MYHLFQLKRETD-DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERV 1747

Query: 5972 Q-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKN 6030
              +    ++LI A + S AA I +  + +N+ W  L ++I +R++ L  ++  + +    
Sbjct: 1748 DNVNAFIERLIDAGH-SEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYD-LHRYFYT 1805

Query: 6031 MSNLRTWLARIESELSKPVVYDVCDDQEIQK-RLAEQQDLQRDIEQHSAGVESVFNICDV 6089
             + +   +     EL + V  D    +   +   A +++L      H  GV+ V    DV
Sbjct: 1806 GAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFEREL------HLLGVQ-VQQFQDV 1858

Query: 6090 LLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEET---WRLWQKFLDDYS 6146
                  A A E + ++IQ   + +   W+ +      RR ++ +T   +R +    D  S
Sbjct: 1859 ATRLQTAYAGE-KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLS 1917

Query: 6147 RFEDWLKSAERTAACPNSSEV---------LYTSAKEELKRFEAFQRQIHERLTQLELIN 6197
              E  ++  E      + S V         +    +   K F A   ++ E L Q +   
Sbjct: 1918 WMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACL-ELGESLLQRQ--- 1973

Query: 6198 KQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESI 6257
             Q     RE      SR K+M  +   RW+ L+     +L  +  F+      E      
Sbjct: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLR-----MLLEVCQFSRDASVAE------ 2022

Query: 6258 LVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPL 6317
              WL   +  L + +     D+ +K+ + +   ++ T +         + E+     +P 
Sbjct: 2023 -AWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS---------WAERFAALEKPT 2072

Query: 6318 DAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDS 6377
               L E ++ E                       P  E   +  E ET  E P      +
Sbjct: 2073 TLELKERQIAE----------------------RPAEETGPQEEEGETAGEAPVSHHAAT 2110

Query: 6378 WRKRGESEEPSSPQSLCHLVAPGHERSG 6405
             R     EE + PQ+L     PG  + G
Sbjct: 2111 ERTSPGEEEGTWPQNLQQPPPPGQHKDG 2138



 Score = 53.9 bits (128), Expect = 5e-06
 Identities = 52/245 (21%), Positives = 104/245 (42%), Gaps = 17/245 (6%)

Query: 6539 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 6598
            QA     +L+   +L  +  +  A   W+ + E  L  ++M     D++ ++ R   L +
Sbjct: 836  QADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQ 895

Query: 6599 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 6658
             +K   T    +  VN+++   +++  P S E++     L+  W+A Q  V   R  +  
Sbjct: 896  EMKTLMTQ---IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952

Query: 6659 SLM---QCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVE 6715
            +L     C D  + S+    W+      +      D   D   ++  +R+L  LE+++  
Sbjct: 953  ALRVHNYCVDCEETSK----WITD--KTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAA 1006

Query: 6716 RQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPAS 6775
             Q +VD L+  S  L+     +   E +E +   +K L++L + + Q L   +      S
Sbjct: 1007 IQARVDALERESQQLM-----DSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVS 1061

Query: 6776 PLPSF 6780
             L +F
Sbjct: 1062 QLQAF 1066



 Score = 47.4 bits (111), Expect = 5e-04
 Identities = 167/882 (18%), Positives = 346/882 (39%), Gaps = 130/882 (14%)

Query: 1871 VEQKLQKLSDFLTLEGRNSKIKQ----------VDSVLKHVKKHLPKAHVKELISWLVGQ 1920
            V+Q+LQ  S + T+E +  K ++          + S ++   + +   H  +L+S +   
Sbjct: 337  VQQQLQAFSTYRTVE-KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRA 395

Query: 1921 EFELEKMESICQ-ARAKEL--EDSLQQLLRLQDDHRNLRK-WLTNQEE---------KWK 1967
               LE+ E   + A   EL  ++ L+QL R  D    +R+ WL+  +             
Sbjct: 396  WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455

Query: 1968 GMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLR 2027
             +E   +K E      A   E+  ++  L   L++  + +++ I      ++  +  L  
Sbjct: 456  AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515

Query: 2028 QLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIK--- 2084
             L    +  +      + F D+ H  I W+ EIK  L+     +  + +E+ +QK K   
Sbjct: 516  LLQSRRQRLETTLALQKLFQDMLHS-IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLME 574

Query: 2085 -EIILLKPEGDARIETIMKQAESS-----EAPLVQKTLTDISNQWDNTLHLAS---TYLS 2135
             +I +   +  A     +K  E       +  ++Q  ++ +   ++   ++A+     L 
Sbjct: 575  ADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLE 634

Query: 2136 HQEKL------LLEGEKYLQSKE----------DLRLMLIELKKKQEAGFALQHGLQEKK 2179
              ++L      + E E +++ KE          DL  +LI L++K +A      GL    
Sbjct: 635  QSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLI-LQRKHKAFEDELRGLDAHL 693

Query: 2180 AQL------KIYKKFLKKAQDLTSLLKELKSQGNYLLE----CTKNPSFSEEPWLEIKHL 2229
             Q+       + +K     Q + + +KE+ +Q + L +    C KN   +E  + + +  
Sbjct: 694  EQIFQEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAEN-FFQFQGD 751

Query: 2230 HESLLQQLQDSVQNLDGH------------VREHDSYQVCVTDLNTTLDNFSKEFVSFSD 2277
             + L   LQD+ + L G              ++H  +   + +    +++  ++   F +
Sbjct: 752  ADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE 811

Query: 2278 KPVDQIAVEEKLQKLQELENRL----SLQDGTLKKILALAKSVKQNTSS---VGQK---- 2326
            +  D   V  +LQ L+EL  ++     L+   L++ L L     +  +    +G+K    
Sbjct: 812  EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWL 871

Query: 2327 ---IIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQAT 2383
                + D ++ L+     +++R     QEM+  +  I                G    A 
Sbjct: 872  AEMEMPDTLEDLEV----VQHRFDILDQEMKTLMTQI---------------DGVNLAAN 912

Query: 2384 SDVQESTQESAAVEKLEED----WEI------NKDSAVEMAMS-KQLSLNAQESMKNTED 2432
            S V+     S  V++ ++     W+        +  AV+ A+      ++ +E+ K   D
Sbjct: 913  SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972

Query: 2433 ERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLH 2492
            + KV E   + L  D         ++  L   + A +A +  LE+ E     ++      
Sbjct: 973  KTKVVE-STKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALER-ESQQLMDSHPEQKE 1030

Query: 2493 NIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKAL-LTDKESLKVGPL 2551
            +IG   +HL+ L Q L    + +E     +   Q +L  ++     L +T K        
Sbjct: 1031 DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090

Query: 2552 DSVTYLDKIKKFIASIEKE----KDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGW 2607
            +S+   +++ +  A I+ E    +DS   +K   E +    TD +  LL  +++ L+ GW
Sbjct: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGW 1150

Query: 2608 EQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHL 2649
              + +  + + S  + +   F       +  E  L  Q+  L
Sbjct: 1151 NALGRMWESR-SHTLAQCLGFQEFQKDAKQAEAILSNQEYTL 1191



 Score = 46.6 bits (109), Expect = 9e-04
 Identities = 152/792 (19%), Positives = 306/792 (38%), Gaps = 122/792 (15%)

Query: 1491 ANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTE---CLEQCGRVLELLKQYQNFKSIL 1547
            ANSL      R + V Q   +    W+  + LV+E    ++   RV       +     +
Sbjct: 911  ANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWI 970

Query: 1548 TTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607
            T   +  ES   L     G   ++++++ +E         ++ +++ +Q           
Sbjct: 971  TDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQ----------- 1019

Query: 1608 MKTFEEPPFEKE-----ANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW- 1661
             +  +  P +KE        + + W  + +  +   + LG    L   L +L +    W 
Sbjct: 1020 -QLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD-FQAWL 1077

Query: 1662 --TEKALQKMELHQLTEEDRERL------KEELQVHE---QKTSEFSRRVAEIQFLLQSS 1710
              T+KA+   ++ +   E  + L      K+E+  H+   Q+  E   +V + Q   +  
Sbjct: 1078 SITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYL 1137

Query: 1711 EIPLELQVMES--SILNKMEHVQKCLTGESNCHALSGSTA--ELREDLDQAKTQIGMTES 1766
             +   L+ +++  + L +M         ES  H L+      E ++D  QA+  +   E 
Sbjct: 1138 LLGQRLEGLDTGWNALGRM--------WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189

Query: 1767 LLKALSPSDSLEI----FTKLEEIQQQILQQKHSMILLENQIGCLTPE----LSELKKQY 1818
             L  L P DSLE       K E+    +   +  ++   +    L  E      ++K++ 
Sbjct: 1190 TLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKV 1249

Query: 1819 ESVSDLFNTKKSVLQDHFSKLLND---------QCKNFNDWFSNIKVNLKECFESSETKK 1869
            + + D         Q+  S LL D          C+    W ++  +  ++   S +  +
Sbjct: 1250 QLIEDRHRKNNEKAQE-ASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDV--SYDEAR 1306

Query: 1870 SVEQKLQKLSDFLT-LEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFE-LEKM 1927
            ++  K  K   F+  L      ++ +D+  K +    P+       + LV Q+ E L ++
Sbjct: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ------FTALVSQKLEALHRL 1360

Query: 1928 ESICQARAKELEDSLQQL----LRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQAL 1983
                QA  KE    L       LRLQ  H +L KW++  E++ +  ++PG+      + L
Sbjct: 1361 WDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS-DDPGKDLTSVNRML 1418

Query: 1984 A-----------RKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEI 2032
            A           RK E  E  AQ+ +  +E G   + ++ +E    +D  + L R+  ++
Sbjct: 1419 AKLKRVEDQVNVRKEELGELFAQVPSMGEEGG---DADLSIEKR-FLDLLEPLGRRKKQL 1474

Query: 2033 EEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPE 2092
            E     L    Q   DL  + + W   ++E L +  S++    L+     +K+   L+ E
Sbjct: 1475 ESSRAKL----QISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526

Query: 2093 ---GDARIETIMK------QAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLE 2143
                  R+E +++      +A   +   +++ L  + + WD     A+  L         
Sbjct: 1527 ILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEA 1586

Query: 2144 GEKYLQSKE--------DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDL 2195
             + YL + E        +L ++  E+ K +E    +   L+    Q +  + + +  + L
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVM---LKRHLRQQRAVEDYGRNIKQL 1643

Query: 2196 TSLLKELKSQGN 2207
             S  + L S G+
Sbjct: 1644 ASRAQGLLSAGH 1655



 Score = 41.6 bits (96), Expect = 0.028
 Identities = 298/1591 (18%), Positives = 596/1591 (37%), Gaps = 270/1591 (16%)

Query: 1807 LTPELSELKKQYESVSDLFNTKKSVLQDHFS--KLLNDQCKNFNDWFSNIKVNLKECFES 1864
            +T     + + +  + +L  +++  L+   +  KL  D   +  DW   IK +L    E 
Sbjct: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSA-EF 556

Query: 1865 SETKKSVEQKLQK---LSDFLTLEGRNSKIKQVDSV-LKHV--KKHLP--KAHVKELISW 1916
             +    VE  LQK   +   + ++G   K+K + +  LK    K + P     +++ IS 
Sbjct: 557  GKHLLEVEDLLQKHKLMEADIAIQG--DKVKAITAATLKFTEGKGYQPCDPQVIQDRISH 614

Query: 1917 LVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKT 1976
            L   E   E++ ++   R  +LE S ++L +   +      W+  +E+ +  ++   + T
Sbjct: 615  L---EQCFEELSNMAAGRKAQLEQS-KRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670

Query: 1977 ELFCQALARKREQFESV-----AQLNN---------SLKEYGFTEEEEIIMEATCLMDRY 2022
             +    L RK + FE       A L           + K++G  + E  I E +   D+ 
Sbjct: 671  SVLI--LQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQL 728

Query: 2023 QTLL----RQLSEIE-----------------EEDKLLPTEDQSFNDLAHDVIHWIKEIK 2061
            + L     + L + E                 +  +LL  ED   ++ A   +   K+ K
Sbjct: 729  KDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALG--KKHK 786

Query: 2062 ESLMVLNSSEGKMP-LEERIQKIKEIILLKPEGDARIETIMK--QAESSEAPLVQKTLTD 2118
            + L  L  S G M  LE++ Q   E     P+   R++ + +  Q   ++A L Q+ L +
Sbjct: 787  DFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846

Query: 2119 ISNQWD--NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQ 2176
              + +           ++  +EK L E E    + EDL ++              QH   
Sbjct: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEMP-DTLEDLEVV--------------QHRFD 891

Query: 2177 EKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQ 2236
                ++K           L + +  +    N L+E     S   + + +  +      Q 
Sbjct: 892  ILDQEMKT----------LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941

Query: 2237 L-QDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQEL 2295
            L  +  + +D  +R H+ Y V   + +  + + +K   S  D   D   +    +KL  L
Sbjct: 942  LVSERREAVDSALRVHN-YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000

Query: 2296 ENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMEC 2355
            E  ++       ++ AL +  +Q   S  ++  K+DI   Q   ++L   L  + Q  E 
Sbjct: 1001 ERDVAAIQA---RVDALERESQQLMDSHPEQ--KEDIGQRQKHLEELWQGLQQSLQGQED 1055

Query: 2356 CLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAM 2415
             L  + + +   +    F       QA   +   TQ++ A E + E     +    + A 
Sbjct: 1056 LLGEVSQLQAFLQDLDDF-------QAWLSI---TQKAVASEDMPESLPEAEQLLQQHAG 1105

Query: 2416 SKQLSLNAQESMKNTEDE-RKVNELQNQPLELDTMLRNEQLEEIEKLYTQL----EAKKA 2470
             K      Q+S +  ++   KV + Q  P   + +L  ++LE ++  +  L    E++  
Sbjct: 1106 IKDEIDGHQDSYQRVKESGEKVIQGQTDP---EYLLLGQRLEGLDTGWNALGRMWESRSH 1162

Query: 2471 AIKP-LEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYL 2529
             +   L   E     +    +L N  Y+  HL+           + E+    +R F+++L
Sbjct: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP--------PDSLEAAEAGIRKFEDFL 1214

Query: 2530 AAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIE----------KEKDSLGNLKI 2579
             ++E++   +L+  +S      +   Y DKIK+ +  IE          +E   L    +
Sbjct: 1215 GSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL 1274

Query: 2580 KWENLSNHVTDM----DKKLLESQ------IKQLEHGW-------------EQVEQQIQK 2616
            + +N   +  ++    + KLL SQ       + L + W             E   + I  
Sbjct: 1275 ELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334

Query: 2617 KYSQQVVEYDEFTTLMNKV--------QDTEISLQQQQQHL------QLRLKSPEERAGN 2662
            +  Q + E  +FT L+++          + + + +++ QHL       LRL++  +   N
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL--N 1392

Query: 2663 QSMIALTTDLQATKHGFSVLKGQAEL-QMKRIWGEKEKKNLEDG---------------- 2705
            + + A+   L++   G  +      L ++KR+  +   +  E G                
Sbjct: 1393 KWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDA 1452

Query: 2706 -INNLKKQWETLEPL---HLEAENQIKKCDIRNKMKETILWAKNLLG-ELNPSIPLLPDD 2760
             ++  K+  + LEPL     + E+   K  I   +++  LW +  L    +         
Sbjct: 1453 DLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQT 1512

Query: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL 2820
            +   ++K +   + IL     VE + +  +  V +    +  DL   L  L++ +  L  
Sbjct: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEA-AEIDCQDLEERLGHLQSSWDRLRE 1571

Query: 2821 KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLI----IPRVETAATEAELKHH--- 2873
             +  R Q+L     E   ++    + +  + E E  +    IP+ E  A    LK H   
Sbjct: 1572 AAAGRLQRLR-DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI-VMLKRHLRQ 1629

Query: 2874 ------------------HVTLEASQKELQEI---DSGISTHLQELTNIYEELNVFERLF 2912
                                 L A   E ++I      +  H   L ++ EE     +L 
Sbjct: 1630 QRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERK--RKLE 1687

Query: 2913 LEDQLKNLKIRTNRIQRFIQ---------NTCNEVEH----KIKFCRQFHEKTSAL-QEE 2958
                L  LK  T+ ++++I              + +H    + KF R F  +T A+ QE 
Sbjct: 1688 NMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKF-RDFARETGAIGQER 1746

Query: 2959 ADSIQRNELLLNQEVNKGVKE--EIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQ 3016
             D++      + + ++ G  E   I   KD L  +   +L+++  +     +  ++D  +
Sbjct: 1747 VDNV---NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTR--MQLLAASYDLHR 1801

Query: 3017 LDQLQTQVF----EKEKELEEKI-KQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLK 3071
                  ++     EK +EL E +     T E  H  + A   ++  + +Q+++  +V  +
Sbjct: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861

Query: 3072 APDSSPESRRLNAQILSQRIEKA-KCLCDEIIKKLNENKTFDDSFK------------EK 3118
               +    +    Q   Q +  A + L D    +  +     D F+            E 
Sbjct: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921

Query: 3119 EILQIKLNAEEND-----KLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQ 3173
             I QI+      D      L K  Q +  E+  +  +   C +  E+ L   +Q   +++
Sbjct: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981

Query: 3174 QPLLINLEIKHIQNEKDNCEAFQEQVWAEMC 3204
            + L   +  +   NEK      + ++  E+C
Sbjct: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVC 2012


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 244,772,465
Number of Sequences: 37866
Number of extensions: 11086603
Number of successful extensions: 61668
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 1087
Number of HSP's that attempted gapping in prelim test: 37804
Number of HSP's gapped (non-prelim): 16008
length of query: 6885
length of database: 18,247,518
effective HSP length: 126
effective length of query: 6759
effective length of database: 13,476,402
effective search space: 91087001118
effective search space used: 91087001118
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 74 (33.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press